CN105920433A - Application of traditional Chinese medicine preparation to preparation of medicine for treating thrombophlebitis - Google Patents
Application of traditional Chinese medicine preparation to preparation of medicine for treating thrombophlebitis Download PDFInfo
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Abstract
The invention discloses application of a traditional Chinese medicine preparation to the preparation of medicine for treating thrombophlebitis, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine preparation is prepared from following 18 kinds of traditional Chinese medicinal materials as raw materials: motherwort herb, herba violae, roots of common peony, leeches, scorpion, radix scrophulariae, herba artemisiae scopariae, coix seeds, cortex phellodendri, akebia quinata decne, herba eupatorii, frankincense, myrrh, rhizoma pleionis, fructus gardenia, bombyx batryticatus, rhizoma alismatis and liquorice roots. The traditional Chinese medicine preparation has the obvious technical advantages of obvious curative effect, high cure rate, ultra-low side effect and the like in the aspect of treating the thrombophlebitis. In addition, the preparation method is simple and convenient; the implementation is easy; and the medicine effect of the obtained preparation is stable. Therefore the traditional Chinese medicine preparation is suitable to be popularized and applied so as to benefit more patients and create high social values.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine preparation in preparation treatment thrombophlebitis medicine
Application.
Background technology
Phlebitis (full name thrombophlebitis) refers to the acute aseptic inflammation of vein blood vessel, according to diseased region not
With, phlebitis can be divided into superficial phlebitis and deep phlebitis.A few patients can have heating, total white blood cells to increase, and patient is usually
State pain and swelling.The cause of disease causing venous thrombosis is a lot, such as wound, operation, gestation, childbirth, heart disease, pernicious swollen
Tumor, oral contraceptive and stand for a long time, squat down, sitting, lying on bed for a long time etc., more typically surgical site infections causes primary disease.
Vein input strong and stimulating, high concentration medicine or the time of use are longer, damage venous endothelial cell；Superficial veins is bent
, blood stasis；Obesity, smoking, wound cause venous endothelial to damage；Antibacterial infection etc..After vein blood vessel inner film injury, formed
Thrombosis, rapidly results in the inflammatory reaction of whole piece superficial vein wall, even involves vein surrounding tissue, and has transudate, topical manifestations
Having strand runner or the beading scleroma of pain, swelling and tenderness, general reaction is inconspicuous.
Phlebitis belongs to the disease categories such as traditional Chinese medical science BI-syndrome involved the blood vessels, arthralgia due to stagnation of blood, superficial obstructive phlebitis, swelling, muscular rheumatism, multiple abscess due to blood stasis, in being more common in, old
People.Its clinical characters is affected part swelling, pain, stands or fatigue increases the weight of, and affected part color of the leather is deepened, skin temperature rise.Its pathogenesis is wet
Heat bet, qi and blood stagnation and qi-blood disharmony and cause.Phlebitis can betide each position of health, is generally mainly in extremity,
Next to that chest and abdomen wall, minority is migrans outbreak.During unilateral morbidity, left side is more than right side.Thrombophlebitis is from traditional Chinese medical science angle
For on, it is divided into three types according to the PD order of severity.
1, yang deficiency cold-condensing type (being equivalent to the first phase)
Suffering limb sends out cool, numb, locally pallor, that touches is ice-cold, has paroxysmal ticpain.Light red tongue, tongue is white, deep-thready pulse.
The rule for the treatment of: warming YANG to expel cold, removing obstruction in the collateral to relieve pain.
2, blood stasis stagnated heat type (being equivalent to the second phase)
The blue dead color of suffering limb skin, severe pain of walking, or lie awake all night, eat anorexia.Red tongue or purple dark, the area on the wrist over the radial artery where the pulse is felt for diagnosis deep-thready pulse is puckery.
The rule for the treatment of: the suitable blood circulation promoting and blood stasis dispelling of blood stasis stagnated heat type, heat clearing away removing obstruction in the collateral to relieve pain.
3, deficiency of YIN noxious dampness type (being equivalent to the third phase)
Suffering limb severe pain or causalgia, profile is withered, the most burned black necrosis, or the rotten muscle of meat is rotten, refers to that apotelus comes off, dim complexion or grey
In vain.Vexed poor appetite.Deep red tongue, yellow and greasy fur, the area on the wrist over the radial artery where the pulse is felt for diagnosis slippery and rapid pulse, loud or stringy and rapid pulse.
The rule for the treatment of: YIN nourishing is detoxified, putrefaction removing of invigorating blood circulation.
Summary of the invention
The technical problem to be solved in the present invention is that a kind of Chinese medicine preparation of exploitation is in preparation treatment thrombophlebitis medicine
Application.
For solving above-mentioned technical problem, the technical scheme that inventor is taked is:
The application in preparation treatment thrombophlebitis medicine of a kind of Chinese medicine preparation, the Chinese prescription of described Chinese medicine preparation is with weight
Amount part is expressed as: Herba Leonuri 15-45 part, Herba Violae 9-27 part, Radix Paeoniae Rubra 7-25 part, Hirudo 11-31 part, Scorpio 4-12 part, profound
Ginseng 12-35 part, Herba Artemisiae Scopariae 12-38 part, Semen Coicis 10-30 part, Cortex Phellodendri 8-24 part, Caulis Akebiae 8-32 part, Herba Eupatorii 7-19 part, Olibanum 6-18
Part, Myrrha 6-20 part, Pseudobulbus cremastrae seu pleiones 7-24 part, Fructus Gardeniae 11-35 part, Bombyx Batryticatus 9-31 part, Rhizoma Alismatis 6-22 part, Radix Glycyrrhizae 8-15 part.
In R&D process, the prescription proportioning with excellent curative effect the most out is expressed as with weight portion:
Herba Leonuri 30 parts, Herba Violae 18 parts, Radix Paeoniae Rubra 17 parts, Hirudo 21 parts, Scorpio 8 parts, Radix Scrophulariae 22 parts, Herba Artemisiae Scopariae 24 parts, Semen Coicis
20 parts, Cortex Phellodendri 16 parts, Caulis Akebiae 15 parts, Herba Eupatorii 13 parts, Olibanum 12 parts, Myrrha 13 parts, Pseudobulbus cremastrae seu pleiones 15 parts, Fructus Gardeniae 23 parts, Bombyx Batryticatus 20
Part, Rhizoma Alismatis 14 parts, 11 parts of Radix Glycyrrhizae.
The preparation method of above-mentioned Chinese medicine preparation is following steps:
(1), ingredients is accurately weighed by Chinese prescription of the present invention；
(2), take Cortex Phellodendri, alcohol-pickled 4-24 hour of Radix Paeoniae Rubra 40-70%, drain, pulverize, parch, grind, cross 70-120 mesh
Sieve, obtains mixing fine powders, standby；
(3), by kind to Herba Leonuri, Herba Violae, Hirudo, Scorpio, Radix Scrophulariae, Herba Artemisiae Scopariae, Semen Coicis, Caulis Akebiae, Herba Eupatorii, Olibanum, Myrrha, mountain
Aunt, Fructus Gardeniae, Bombyx Batryticatus, Rhizoma Alismatis, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial 5-16 times of weight of medical material, soak 4-24 little
Time, backflow decocts 1-6 hour, filters, and adds the purified water of 4-12 times of weight of initial weight, and backflow decocts 1-5 hour, filters
And retain filtering residue, merging filtrate, it is concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25 standby；
(4), the filtering residue of step (3) adding the ethanol of concentration 65-85% of 5-14 times of weight, reflux, extract, 2 times, each 1-5 is little
Time, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25
With；
(5), the concentrated solution of step (3) and (4) gained is merged, add the mixing fine powders of step (2), mix homogeneously, continue dense
Being reduced to 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.42-1.47, standby；
(6), by the traditional Chinese medicine thick paste of step (5), add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make and face
Chinese medicine finished product preparation required for Chuan, such as decoction, pill (containing the watered pill, honeyed pill, concentrated pill, drop pill, wax pill, paste pill), tablet, tincture
The dosage forms such as agent, capsule (containing soft capsule), granule, powder, syrup.
The nature and flavor of the raw materials used medical material of Chinese medicine preparation of the present invention, return through and function effect:
Herba Leonuri: this product is the fresh of labiate Herba Leonuri or dry aerial parts.Bitter in the mouth, pungent, cold nature；Return liver, the heart
Bao Jing；Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.
Herba Violae: this product is the dry herb of Violaceae Chinese violet.Bitter in the mouth, pungent, cold in nature；GUIXIN, Liver Channel；Clearly
Thermal detoxification, removing heat from blood is subsided a swelling.
Radix Paeoniae Rubra: this product is ranunculaceae plant Radix Paeoniae or the dry root of river Radix Paeoniae Rubra.Bitter in the mouth, cold nature；Return Liver Channel；Heat clearing away is cool
Blood, eliminating stasis to stop pain.
Hirudo: this product is Hirudinidae animal whitmania, Hirudo or the dry body of Folium Salicis Babylonicae Hirudo.Salty in the mouth, hardship, property is put down；Return Liver Channel；
Removing blood stasis, removing blood stasis, stimulates the menstrual flow.
Scorpio: this product is the dry body of Buthidae animal Scorpio.Acrid in the mouth, property is put down；Return Liver Channel；Endogenous wind stopping spasmolytic, counteracting toxic substances
Eliminating stagnation, removing obstruction in the collateral to relieve pain.
Radix Scrophulariae: this product is the dry root of goatweed Radix Scrophulariae.Sweet in the mouth, hardship, salty, cold nature；Return lung, stomach, kidney channel；Removing heat from blood
YIN nourishing, eliminating fire and detoxication.
Herba Artemisiae Scopariae: this product is the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. or Herba Artemisiae Scopariae.Bitter in the mouth, pungent, cold nature；Return spleen, stomach,
Liver, gallbladder meridian；Clearing away damp-heat, jaundice eliminating subcutaneous ulcer.
Semen Coicis: this product is the dry mature kernal of grass Semen Coicis.Sweet in the mouth, light, cool in nature；Return spleen, stomach, lung meridian；Strong
Spleen eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.
Cortex Phellodendri: this product is the dry bark of rutaceae wampee or Cortex Phellodendri.Bitter in the mouth, cold in nature；Return kidney, bladder warp；Clearly
Hot dampness, pathogenic fire purging is except steaming, detoxification sore treatment.
Caulis Akebiae: for plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, the woody stems of Caulis Akebiae.Bitter in the mouth, cool in nature；Enter the heart, small intestinal, wing
Guang warp；Pathogenic fire purging row water, promoting blood circulation.
Herba Eupatorii: this product is the dry aerial parts of feverfew Herba Eupatorii.Summer, Qiu Erji tap at twice, remove impurity, shine
Dry.Acrid in the mouth, property is put down.Return spleen, stomach, lung meridian.Removing dampness by means of aromatics, appetizing of being amusing, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, mouth
In sweet greasy, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.
Olibanum: Burseraceae Boswellia carterii platymiscium Boswellia carterii, medicine glue XIANGSHU and wild Boswellia carterii etc., oozes with its trunk skin zone wound
The oleo-gum-resin gone out is used as medicine.Acrid in the mouth is bitter, warm in nature；Enter the heart, liver, spleen channel；Regulating qi and activating blood, analgesic therapy, chase after poison.
Myrrha: Burseraceae bdellium plant myrrh and belong to him together and plant the oleo-gum-resin that the trunk skin zone of plant oozes out.Taste
Hardship, property is put down；Enter Liver Channel；Eliminating stasis to stop pain, externally used detumescence granulation promoting.
Pseudobulbus cremastrae seu pleiones: this product is the dry pseudobulb of orchid Cremastra appendiculata, pleione bulbocodioides or Pleione yunnanensis.It is sweet in the mouth, micro-pungent,
Cool in nature；Return liver, spleen channel；Heat-clearing and toxic substances removing, dissipating phlegm and resolving masses.
Fructus Gardeniae: this product is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.Bitter in the mouth, cold in nature；GUIXIN, lung, tri-jiao channel；Really
Real: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.
Bombyx Batryticatus: this product is that the larva in Bombycidae insecticide silkworm 4-5 age infects (or artificial vaccination) muscardine and lethal children
Worm dry body.Salty in the mouth, pungent, property is put down；Return liver, lung, stomach warp；Expelling wind for relieving convulsion, dissipating phlegm and resolving masses.
Rhizoma Alismatis: this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.Sweet in the mouth, cold in nature；Return kidney, bladder warp；Diuresis is the wettest
Heat.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down；GUIXIN, lung,
Spleen, stomach warp；Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The side of Chinese prescription of the present invention solves:
This Chinese prescription is with Herba Leonuri, Herba Artemisiae Scopariae, Fructus Gardeniae, Hirudo, Bombyx Batryticatus, Radix Scrophulariae as monarch drug, promoting blood flow to regulate menstruation, clearing away heat-damp and promoting diuresis, cool
Blood removing toxic substances, removing blood stasis, dissipating phlegm and resolving masses, removing heat from blood YIN nourishing；With Semen Coicis, Herba Violae, Radix Paeoniae Rubra, Cortex Phellodendri as ministerial drug, row is dense, cool in heat clearing away
Blood detumescence, eliminating stasis to stop pain, detoxification sore treatment；With Scorpio, Pseudobulbus cremastrae seu pleiones, Caulis Akebiae, Myrrha as adjuvant drug, removing obstruction in the collateral to relieve pain, dissipating phlegm and resolving masses, tonneau
Blood vessels, eliminating stasis to stop pain；With Herba Eupatorii, Rhizoma Alismatis, Olibanum for making medicine, removing dampness by means of aromatics, diuretic heat clearing away, regulating qi and activating blood；With Radix Glycyrrhizae mediation monarch
Minister assistant makes all property of medicine matter, makes all medicine YIN and YANG balancing, and the exterior and the interior is mutually auxiliary, synergism, thus reaches promoting blood flow to regulate menstruation, clearing away heat-damp and promoting diuresis, cool
The effects such as blood removing toxic substances, removing blood stasis, dissipating phlegm and resolving masses, removing heat from blood YIN nourishing, eliminating stasis to stop pain, detoxification sore treatment, dissipating phlegm and resolving masses, promoting blood circulation,
Thrombophlebitis is had the most significant therapeutic effect.
Compared with prior art, Chinese medicine preparation of the present invention has that curative effect is prominent, cure rate high, side effect is extremely low etc. significantly
Technical advantage；Further, the preparation method of the present invention is simple and easy to do, gained preparation efficacy stability, therefore, is suitable for popularization and application with favour
And more patient, create bigger social value.
Detailed description of the invention
Embodiment 1
With the maximum of Chinese prescription scope of the present invention and it is considered herein that optimum technological parameter produce granule:
(1), Herba Leonuri 4500g, Herba Violae 2700g, Radix Paeoniae Rubra 2500g, Hirudo are accurately weighed by Chinese prescription of the present invention
3100g, Scorpio 1200g, Radix Scrophulariae 3500g, Herba Artemisiae Scopariae 3800g, Semen Coicis 3000g, Cortex Phellodendri 2400g, Caulis Akebiae 3200g, Herba Eupatorii 1900g,
Olibanum 1800g, Myrrha 2000g, Pseudobulbus cremastrae seu pleiones 2400g, Fructus Gardeniae 3500g, Bombyx Batryticatus 3100g, Rhizoma Alismatis 2200g, Radix Glycyrrhizae 1500g；
(2), take Cortex Phellodendri, Radix Paeoniae Rubra with alcohol-pickled 8 hours of 60%, drain, pulverize, parch, grind, cross 80 mesh sieves, must mix carefully
Powder, standby；
(3), by kind to Herba Leonuri, Herba Violae, Hirudo, Scorpio, Radix Scrophulariae, Herba Artemisiae Scopariae, Semen Coicis, Caulis Akebiae, Herba Eupatorii, Olibanum, Myrrha, mountain
Aunt, Fructus Gardeniae, Bombyx Batryticatus, Rhizoma Alismatis, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial 12 times of weight of medical material, soak 10 hours, return
Stream decocts 2 hours, filters, and adds the purified water of 8 times of weight of initial weight, and backflow decocts 2 hours, filters and retain filtering residue,
Merging filtrate, is concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25 standby；
(4), the filtering residue of step (3) is added the ethanol of the concentration 70% of 11 times of weight, reflux, extract, 2 times, each 2 hours, filters,
Merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25；
(5), the concentrated solution of step (3) and (4) gained is merged, add the mixing fine powders of step (2), mix homogeneously, continue dense
Being reduced to 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.42-1.47, standby；
(6), by the traditional Chinese medicine thick paste of step (5), add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make
Granule, specification is: 0.56g crude drug/g granule.
Embodiment 2
With the minima of Chinese prescription scope of the present invention and it is considered herein that optimum technological parameter produce granule:
(1), by Chinese prescription of the present invention accurately weigh Herba Leonuri 1500g, Herba Violae 900g, Radix Paeoniae Rubra 700g, Hirudo 1100g,
Scorpio 400g, Radix Scrophulariae 1200g, Herba Artemisiae Scopariae 1200g, Semen Coicis 1000g, Cortex Phellodendri 800g, Caulis Akebiae 800g, Herba Eupatorii 700g, Olibanum 600g, do not have
Medicine 600g, Pseudobulbus cremastrae seu pleiones 700g, Fructus Gardeniae 1100g, Bombyx Batryticatus 900g, Rhizoma Alismatis 600g, Radix Glycyrrhizae 800g；
(2), take Cortex Phellodendri, Radix Paeoniae Rubra with alcohol-pickled 8 hours of 60%, drain, pulverize, parch, grind, cross 80 mesh sieves, must mix carefully
Powder, standby；
(3), by kind to Herba Leonuri, Herba Violae, Hirudo, Scorpio, Radix Scrophulariae, Herba Artemisiae Scopariae, Semen Coicis, Caulis Akebiae, Herba Eupatorii, Olibanum, Myrrha, mountain
Aunt, Fructus Gardeniae, Bombyx Batryticatus, Rhizoma Alismatis, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial 12 times of weight of medical material, soak 10 hours, return
Stream decocts 2 hours, filters, and adds the purified water of 8 times of weight of initial weight, and backflow decocts 2 hours, filters and retain filtering residue,
Merging filtrate, is concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25 standby；
(4), the filtering residue of step (3) is added the ethanol of the concentration 70% of 11 times of weight, reflux, extract, 2 times, each 2 hours, filters,
Merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25；
(5), the concentrated solution of step (3) and (4) gained is merged, add the mixing fine powders of step (2), mix homogeneously, continue dense
Being reduced to 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.42-1.47, standby；
(6), by the traditional Chinese medicine thick paste of step (5), add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make
Granule, specification is: 0.56g crude drug/g granule.
Embodiment 3
With the arbitrary value of Chinese prescription scope of the present invention and it is considered herein that optimum technological parameter produce granule:
(1), by Chinese prescription of the present invention accurately weigh Herba Leonuri 4500g, Herba Violae 900g, Radix Paeoniae Rubra 2400g, Hirudo 1200g,
Scorpio 500g, Radix Scrophulariae 3400g, Herba Artemisiae Scopariae 1300g, Semen Coicis 3000g, Cortex Phellodendri 2400g, Caulis Akebiae 900g, Herba Eupatorii 1800g, Olibanum 800g,
Myrrha 1000g, Pseudobulbus cremastrae seu pleiones 2200g, Fructus Gardeniae 1300g, Bombyx Batryticatus 3000g, Rhizoma Alismatis 700g, Radix Glycyrrhizae 1400g；
(2), take Cortex Phellodendri, Radix Paeoniae Rubra with alcohol-pickled 8 hours of 60%, drain, pulverize, parch, grind, cross 80 mesh sieves, must mix carefully
Powder, standby；
(3), by kind to Herba Leonuri, Herba Violae, Hirudo, Scorpio, Radix Scrophulariae, Herba Artemisiae Scopariae, Semen Coicis, Caulis Akebiae, Herba Eupatorii, Olibanum, Myrrha, mountain
Aunt, Fructus Gardeniae, Bombyx Batryticatus, Rhizoma Alismatis, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial 12 times of weight of medical material, soak 10 hours, return
Stream decocts 2 hours, filters, and adds the purified water of 8 times of weight of initial weight, and backflow decocts 2 hours, filters and retain filtering residue,
Merging filtrate, is concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25 standby；
(4), the filtering residue of step (3) is added the ethanol of the concentration 70% of 11 times of weight, reflux, extract, 2 times, each 2 hours, filters,
Merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25；
(5), the concentrated solution of step (3) and (4) gained is merged, add the mixing fine powders of step (2), mix homogeneously, continue dense
Being reduced to 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.42-1.47, standby；
(6), by the traditional Chinese medicine thick paste of step (5), add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make
Granule, specification is: 0.56g crude drug/g granule.
Embodiment 4
With the optimum ratio value of Chinese prescription of the present invention and it is considered herein that optimum technological parameter produce granule:
(1), Herba Leonuri 3000g, Herba Violae 1800g, Radix Paeoniae Rubra 1700g, Hirudo are accurately weighed by Chinese prescription of the present invention
2100g, Scorpio 800g, Radix Scrophulariae 2200g, Herba Artemisiae Scopariae 2400g, Semen Coicis 2000g, Cortex Phellodendri 1600g, Caulis Akebiae 1500g, Herba Eupatorii 1300g, breast
Fragrant 1200g, Myrrha 1300g, Pseudobulbus cremastrae seu pleiones 1500g, Fructus Gardeniae 2300g, Bombyx Batryticatus 2000g, Rhizoma Alismatis 1400g, Radix Glycyrrhizae 1100g；
(2), take Cortex Phellodendri, Radix Paeoniae Rubra with alcohol-pickled 8 hours of 60%, drain, pulverize, parch, grind, cross 80 mesh sieves, must mix carefully
Powder, standby；
(3), by kind to Herba Leonuri, Herba Violae, Hirudo, Scorpio, Radix Scrophulariae, Herba Artemisiae Scopariae, Semen Coicis, Caulis Akebiae, Herba Eupatorii, Olibanum, Myrrha, mountain
Aunt, Fructus Gardeniae, Bombyx Batryticatus, Rhizoma Alismatis, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial 12 times of weight of medical material, soak 10 hours, return
Stream decocts 2 hours, filters, and adds the purified water of 8 times of weight of initial weight, and backflow decocts 2 hours, filters and retain filtering residue,
Merging filtrate, is concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25 standby；
(4), the filtering residue of step (3) is added the ethanol of the concentration 70% of 11 times of weight, reflux, extract, 2 times, each 2 hours, filters,
Merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25；
(5), the concentrated solution of step (3) and (4) gained is merged, add the mixing fine powders of step (2), mix homogeneously, continue dense
Being reduced to 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.42-1.47, standby；
(6), by the traditional Chinese medicine thick paste of step (5), add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make
Granule, specification is: 0.56g crude drug/g granule.
Embodiment 5
The toxicity test of Chinese medicine preparation of the present invention
(1), test material
Experimental animal: SPF level KM mice, body weight 20 ± 4g, SD rat, body weight 226 ± 13g, equal male and female half and half, raw prosperous from Shanghai
Laboratory animal cultivates company limited and buys.
Trial drug: the granule that embodiment of the present invention 1-4 is produced, specification is 0.56g crude drug/g granule.
(2), acute toxicity test
Mice is pressed 0.7g/ml, 50ml/kg dosage gavage and gives Chinese medicine granules of the present invention, one day 3 times, is spaced 4h.Connect after administration
Continuous observing 14d, all test mice skins, hair color are normal, and nose, eye, oral cavity be normal and secretions without exception, without vomiting phenomenon,
Body weight increases, movable, diet drinking-water and two is just normal, and unfavorable condition and death does not occurs in animal.Within 15th day, put to death and dissect dynamic
Thing, perusal main organs is no abnormal.Rat is pressed 0.7g/ml, 50ml/kg dosage gavage and gives Chinese medicinal granule of the present invention
Agent, one day 3 times, Continuous Observation 14d after medicine, all tested rat skins, hair color are normal, nose, eye, normal and without exception point of oral cavity
Secretion, without vomiting phenomenon, body weight increases, movable, diet drinking-water and two is just normal, and unfavorable condition and death does not occurs in animal.The
Within 15 days, putting to death and dissect animal, perusal main organs is no abnormal.This product mice, one day administration total amount of rat are into
250 times of people (0.42g crude drug/kg/d), point out Chinese medicine granules drug safety of the present invention the highest.
(3), long term toxicity test
Selection SD rat, male and female half and half, random packet: blank group and Chinese medicine granules of the present invention high, medium and low dosage group,
The high, medium and low dosage of Chinese medicine granules of the present invention: 100.8g crude drug/kg/d, 33.6g crude drug/kg/d, 11.2g crude drug/kg/d, point
Do not intend the 180 of consumption, 60,20 times for Coming-of-Age Day clinic, use gastric infusion, once a day, successive administration 6 months, and drug withdrawal 1
Within individual month, make restorative observation.Observe the outward appearance of animal, general behavior, body weight, the change of diet amount of drinking water during test, each group is entered
Row hemanalysis, blood biochemical analysis and organ coefficient, blank group and high dose group carry out histopathology index checking.
Result of the test shows: in blank group and Chinese medicine composition of the present invention, low dose group animal general state good,
Outward appearance sign, behavioral activity, glandular secretion, breathing, two just, body weight increases, is administered reaction and the change the most without exception of drinking water diet amount
Change.Reducing occurs in high dose group the weight of animals, accidental soft stool, but recovers after drug withdrawal.In terms of hemanalysis, have indivedual index with
Matched group is more variant, and blood biochemical analysis indexes no abnormality seen changes.Be administered 3 months, each administration group is dirty after drug withdrawal 1 month
Device coefficient compares with blank group without the poorest.Be administered 3 months, be administered 6 months, each treated animal is the dirtiest after drug withdrawal 1 month
The color and luster of device, quality are normal, and naked eyes have no and change significantly.Pathological examination, blank group is the dirtiest with high dose group
Device tissue has no the Pathologic changes relevant to medicine.Result shows that Chinese medicine granules of the present invention is administered rat for continuous 6 months
Gastric infusion has no significant effect, and without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no that retardance toxicity is anti-
Should, the dose safety pointing out Chinese medicine granules clinical practice of the present invention is the highest.
Embodiment 6
The pharmacodynamic experiment of Chinese medicine preparation of the present invention
1, this product impact (turbidimetry) on rat platelet maximum agglutination rate
Take Wistar rat 80, be randomly divided into matched group；Positive control drug thrombus-resisting capsules (traditional Chinese medicines quasi-word Z20003274, Shaanxi
West China Pharmacy stock Co., Ltd) 12.4g/kg group；Granule manufactured by the embodiment of the present invention 3 (specification is: 0.56g crude drug/
G granule) 16.8g/kg, 8.4g/kg, 4.2g/kg group (clinical the 40 of consumption per day, 20,10 times), the embodiment of the present invention 4 is made
Granule (specification is: 0.56g crude drug/g granule) 16.8g/kg, 8.4g/kg, 4.2g/kg group (the clinical consumption per day made
40,20,10 times), totally 8 groups, often group 10.Test medicine distilled water is configured to suspension, and rat ig is administered 15ml/kg, right
Giving same volume distilled water according to group, be administered once daily, continuous 5 days, lh after last is administered, apparatus was with 2% cassia oil one petroleum ether
Silication, pentobarbital sodium anaesthetizes, and aorta takes blood, sodium citrate 9:1 anticoagulant, and 1500 to leave heart 20min supernatant be rich platelet
Blood plasma (PRP), 4000 to leave heart 20min supernatant be platelet poor plasma (PRP), corrects platelet aggregation instrument, surveys platelet
Big aggregation rate.Result withRepresent, t inspection between statistical procedures method employing group.1h blood after the administration of each treated animal last
Platelet maximum agglutination rate is as shown in table 1.
Table 1 Chinese medicine preparation of the present invention on the impact of rat platelet maximum agglutination rate (, n=10)
Note: compare with matched group, * P ＜ 0.05, * * P ＜ 0.01, * * * P ＜ 0.001；&P ＜ is compared with thrombus-resisting capsules group
0.05 ， &&P ＜ 0.01.
From the experimental data listed by table 1 it can be seen that Chinese medicine preparation group of the present invention and the platelet of thrombus-resisting capsules treated animal
Maximum agglutination rate is all significantly lower than matched group.Above-mentioned result of the test shows, rat platelet maximum is gathered by Chinese medicine preparation of the present invention
Collection rate has obvious inhibitory action, and this inhibitory action dosage high, middle group highly significant is better than thrombus-resisting capsules, low dosage
Group is significantly better than thrombus-resisting capsules；Point out Chinese medicine preparation of the present invention to have obvious anti thrombotic action, phlebitis had preferable curative effect,
And it is evident in efficacy is better than thrombus-resisting capsules.
2, the Chinese medicine preparation of the present invention impact on mouse peritoneal capillary permeability
Take Kunming mouse 80, male and female half and half, be divided into 8 groups, often group 10.It is administered: blank group (isometric(al)
Distilled water), aspirin group (0.2g/kg), embodiment 3 experimental group give respectively granule manufactured by the embodiment of the present invention 3 high,
In, the granule of low 3 dosage, embodiment 4 experimental group gives granule high, medium and low 3 manufactured by the embodiment of the present invention 4 respectively
The granule of individual dosage, dosage is ibid.Each group mice with 20mL/kg gastric infusion, after being administered 1h be injected intravenously 0.5% she
Train of thought indigo plant normal saline solution 0.1ml/10g body weight, the acetic acid of lumbar injection 0.7% immediately, 0.2ml/, by little after 20min
Mus takes off cervical vertebra and puts to death, abdominal cut integumentary musculature, with 10ml normal saline mark time washing abdominal cavity, draws cleaning mixture and is incorporated into
10ml, 3000 revs/min of centrifugal 15min；Take supernatant 752 type spectrophotometers its absorbance of colorimetric determination at 590nm, with
T inspection carries out statistical procedures, the results are shown in Table 2.
Table 2 Chinese medicine preparation on the impact (n=10) of mouse peritoneal capillary permeability ()
Note: compare with blank group, * P ＜ 0.05, * * P ＜ 0.01；， &P ＜ 0.05 compared with aspirin group.
Table 2 result shows, embodiment 3, the made granule of embodiment 4 and aspirin all can significantly reduce mouse peritoneal in pole
Capillary permeability, shows that embodiment 3, the made granule of embodiment 4 and aspirin all have certain antiinflammatory action, and
And, 3 dosage of this action intensity are all significantly better than aspirin.
3,0.6%HAC is caused the analgesic activity that mice pain reacts:
Take male and healthy mice 80, be randomly divided into 8 groups, the high, medium and low dosage of Chinese medicine granules of the embodiment of the present invention 3 preparation
Group, the Chinese medicine granules high, medium and low dosage group of the embodiment of the present invention 4 preparation, thrombus-resisting capsules group and blank group, dosage is same
On, all by the volume gastric infusion of 0.25ml/10g body weight, blank group gives isopyknic water gastric infusion, for three days on end, divides
Not Ce Ding 1 hour lumbar injection 0.6%HAC, 0.1ml/10g Mus weight after last medicine, there is the incubation period and 15 of writhing response in record
Minute interior writhing number of times, calculates pain suppression ratio (%) by formula, result withRepresenting, statistical procedures method uses
T inspection between group, result is as shown in table 3.
Table 3 Chinese medicine granules of the present invention to 0.6%HAC cause mice pain reaction effect (, n=10)
Note: compare * P ＜ 0.05, * * P ＜ 0.01 with blank group；&P ＜ 0.05 compared with thrombus-resisting capsules group.
From table 3 result, Chinese medicine granules of the present invention dosage high, middle all can substantially suppress the writhing incubation period of mice.
The significant difference having in various degree is compared with blank group；The high, medium and low dosage of Chinese medicine granules of the present invention and thrombus-resisting capsules
All can significantly reduce the writhing number of times of mice, compare, with blank group, the significant difference having in various degree, point out Chinese medicine of the present invention
Granule has preferable analgesic activity.In terms of pain suppression ratio result: the high, medium and low dosage of Chinese medicine granules of the present invention is superior to
Thrombus-resisting capsules, dosage high, middle has significant difference.
In sum, pharmacodynamic experiment shows, Chinese medicine granules of the present invention has preferable antithrombotic, antiinflammatory and analgesia to make
With, point out Chinese medicine preparation of the present invention that thrombophlebitis there may be significant curative effect.
Embodiment 7
The clinical trial of Chinese medicine preparation of the present invention
The experimenter of this time clinical trial has 342 examples, is all from certain the People's Hospital of city, age 43-68 year, by random for all patients
Be divided into three groups, respectively matched group, test 1 group and test 2 groups, often organize 114 examples.The age of three groups of patients, sex, symptom, disease
The different equal not statistically significant of path difference (P ＞ 0.05), has comparability.Matched group patient is administered orally thrombus-resisting capsules (the quasi-word of traditional Chinese medicines
Z20003274, Shaanxi Huaxi Pharmaceutical Co., Ltd.), three times a day, each 8,3 weeks be a course for the treatment of, continuously treatment 4
The course for the treatment of.Test 1 group of granule being administered orally manufactured by the embodiment of the present invention 3 (specification is: 0.56g crude drug/g granule), every day 3
Secondary, each 15g, 3 weeks is a course for the treatment of, continuously 4 courses for the treatment of of treatment.Test 2 groups of granules being administered orally manufactured by the embodiment of the present invention 4
Agent (specification is: 0.56g crude drug/g granule), instructions of taking is with test 1 group.After all patient treatments terminate, by therapeutic outcome
Statistical analysis is as shown in table 4.
Table 4 result of the test statistical table
Table 4 result of the test shows, compared with matched group, test group evident in efficacy, the cure rate particularly testing 2 groups reaches
52.6%, it is 3.15 times of matched group, total effective rate 86.8%, exceed 20.1 percentage points than matched group；Therefore, with prior art
Compare Chinese medicine preparation of the present invention and there is the most prominent treatment advantage, so the present invention has the most significant skill in its field
Art advantage, it is thus achieved that the technological achievement attracted people's attention, its creativeness is apparent from.
Claims (4)
1. a Chinese medicine preparation is preparing the application treated in thrombophlebitis medicine, it is characterised in that in parts by weight, institute
The Chinese prescription stating Chinese medicine preparation is: Herba Leonuri 15-45 part, Herba Violae 9-27 part, Radix Paeoniae Rubra 7-25 part, Hirudo 11-31 part, complete
Scorpion 4-12 part, Radix Scrophulariae 12-35 part, Herba Artemisiae Scopariae 12-38 part, Semen Coicis 10-30 part, Cortex Phellodendri 8-24 part, Caulis Akebiae 8-32 part, Herba Eupatorii 7-19
Part, Olibanum 6-18 part, Myrrha 6-20 part, Pseudobulbus cremastrae seu pleiones 7-24 part, Fructus Gardeniae 11-35 part, Bombyx Batryticatus 9-31 part, Rhizoma Alismatis 6-22 part, Radix Glycyrrhizae
8-15 part.
The Chinese medicine preparation the most according to claim 1 application in preparation treatment thrombophlebitis medicine, its feature exists
In, in parts by weight, the Chinese prescription of described Chinese medicine preparation is: Herba Leonuri 30 parts, Herba Violae 18 parts, Radix Paeoniae Rubra 17 parts, Hirudo
21 parts, Scorpio 8 parts, Radix Scrophulariae 22 parts, Herba Artemisiae Scopariae 24 parts, Semen Coicis 20 parts, Cortex Phellodendri 16 parts, Caulis Akebiae 15 parts, Herba Eupatorii 13 parts, Olibanum 12 parts,
Myrrha 13 parts, Pseudobulbus cremastrae seu pleiones 15 parts, Fructus Gardeniae 23 parts, Bombyx Batryticatus 20 parts, Rhizoma Alismatis 14 parts, 11 parts of Radix Glycyrrhizae.
The Chinese medicine preparation the most according to claim 1 and 2 application in preparation treatment thrombophlebitis medicine, its feature
Being, the preparation method of described Chinese medicine preparation is following steps:
(1), ingredients is accurately weighed by Chinese prescription；
(2), take Cortex Phellodendri, alcohol-pickled 4-24 hour of Radix Paeoniae Rubra 40-70%, drain, pulverize, parch, grind, cross 70-120 mesh
Sieve, obtains mixing fine powders, standby；
(3), by kind to Herba Leonuri, Herba Violae, Hirudo, Scorpio, Radix Scrophulariae, Herba Artemisiae Scopariae, Semen Coicis, Caulis Akebiae, Herba Eupatorii, Olibanum, Myrrha, mountain
Aunt, Fructus Gardeniae, Bombyx Batryticatus, Rhizoma Alismatis, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial 5-16 times of weight of medical material, soak 4-24 little
Time, backflow decocts 1-6 hour, filters, and adds the purified water of 4-12 times of weight of initial weight, and backflow decocts 1-5 hour, filters
And retain filtering residue, merging filtrate, it is concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25 standby；
(4), the filtering residue of step (3) adding the ethanol of concentration 65-85% of 5-14 times of weight, reflux, extract, 2 times, each 1-5 is little
Time, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.22-1.25
With；
(5), the concentrated solution of step (3) and (4) gained is merged, add the mixing fine powders of step (2), mix homogeneously, continue dense
Being reduced to 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.42-1.47, standby；
(6), by the traditional Chinese medicine thick paste of step (5), add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make and face
The Chinese medicine finished product preparation that bed needs.
The Chinese medicine preparation the most according to claim 3 application in preparation treatment thrombophlebitis medicine, its feature exists
In, described Chinese medicine preparation is made into decoction, pill, tablet, tincture, capsule, granule, powder or syrup.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628785A (en) * | 2004-09-28 | 2005-06-22 | 姜奎祥 | Quick acting Chinese medicine for dissolving thrombolysis and dredging collaterals and its preparation method |
| CN102600239A (en) * | 2012-04-27 | 2012-07-25 | 由丽萍 | Medicament for treating thromboangitis obliterans and preparation method thereof |
| CN104189273A (en) * | 2014-07-26 | 2014-12-10 | 杨建平 | Traditional Chinese medicine used for treating thrombophlebitis |
-
2016
- 2016-04-27 CN CN201610269346.0A patent/CN105920433A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628785A (en) * | 2004-09-28 | 2005-06-22 | 姜奎祥 | Quick acting Chinese medicine for dissolving thrombolysis and dredging collaterals and its preparation method |
| CN102600239A (en) * | 2012-04-27 | 2012-07-25 | 由丽萍 | Medicament for treating thromboangitis obliterans and preparation method thereof |
| CN104189273A (en) * | 2014-07-26 | 2014-12-10 | 杨建平 | Traditional Chinese medicine used for treating thrombophlebitis |
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Application publication date: 20160907 |