CN102895450B - External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene - Google Patents

External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene Download PDF

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CN102895450B
CN102895450B CN201210447876.1A CN201210447876A CN102895450B CN 102895450 B CN102895450 B CN 102895450B CN 201210447876 A CN201210447876 A CN 201210447876A CN 102895450 B CN102895450 B CN 102895450B
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parts
gangrene
chinese medicine
fester
vasculitis
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CN102895450A (en
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刘希山
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Shandong Shenghong Medicine Science & Technology Co Ltd
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Shandong Shenghong Medicine Science & Technology Co Ltd
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Abstract

The invention discloses an external Chinese herbal preparation for treating angiitis fester and gangrene and a method for preparing the external Chinese herbal preparation for treating angiitis fester and gangrene. The method comprises the following steps that: (1) the active pharmaceutical ingredients including 15-20 parts of amur cork tree bark, 20-30 parts of cortex pseudolaricis, 20-30 parts of fructus cnidii, 35-40 parts of Chinese gall, 5-10 parts of myrrha, 5-10 parts of frankincense, 15-20 parts of pubescent holly root, 25-30 parts of radix notoginseng and 25-30 parts of sanguis draconis are ground and mixed, are then added with water to be refluxed and extracted and are finally filtered to respectively obtain pharmaceutical liquid and pharmaceutical residues, the pharmaceutical residues are added with water to be refluxed and extracted, the obtained pharmaceutical liquid after two times of filtration are mixed and concentrated, and the original Chinese herbal liquid is obtained through ethanol, is added with distilled water to be diluted and is mixed and finely filtered to be filled and sealed, so that the Chinese herbal preparation for treating angiitis fester and gangrene is obtained. The external Chinese herbal preparation is reasonable in compound and ratio and treats under the cooperation of a percutaneous absorption therapy, the active pharmaceutical ingredients which subcutaneously permeate can directly reach focuses, so that good absorption and curative effects are realized for patients, and the curative ratio is high.

Description

A kind ofly treat that vasculitis is festered, the Chinese medicine for outer use and preparation method thereof of gangrene
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind ofly treat that vasculitis is festered, the Chinese medicine for outer use and preparation method thereof of gangrene.
Background technology
Vasculitis is tremulous pulse and vein blood vessel inflammation, and therefore the obstructed clinical symptoms causing of tremulous pulse and vein obstruction is vasculitis.For treating, vasculitis is festered, the treatment of gangrene both at home and abroad at present, the common object that adopts oral anti-inflammatory drug or have an intravenous drip to reach antiinflammatory, but due to vasculitis patient's blood vessel blockage, cannot make enough effective medicines arrive focus, therefore cause therapeutic effect poor high with medical expense; For severe patient, adopt the method for amputation more, cause suffering and deformity to patient.Above method, its curative effect is all undesirable.
Summary of the invention
First technical problem to be solved by this invention is: the deficiency existing for prior art, provides a kind of and make that dosage is few, instant effect, short treating period, medical expense are low, do not have an injection, do not take medicine, not amputation and treatment vasculitis easy to use is festered, the Chinese medicine for outer use of gangrene.
Second technical problem to be solved by this invention is: the deficiency existing for prior art, provides a kind of and make that dosage is few, instant effect, short treating period, medical expense are low, do not have an injection, do not take medicine, not amputation and treatment vasculitis easy to use is festered, the preparation method of the Chinese medicine for outer use of gangrene.
For solving above-mentioned first technical problem, technical scheme of the present invention is:
Treat vasculitis fester, gangrene a Chinese medicine for outer use, be prepared from by the raw material that comprises following weight portion: 15~20 parts of Cortex Phellodendris, 20~30 parts of Cortex Pseudolariciss, 20~30 parts of Fructus Cnidiis, 35~40 parts of Galla Chinensiss, 5~10 parts of Myrrhas, 5~10 parts of Olibanums, 15~20 parts of Radix Ilicis Pubescentiss, 25~30 parts of Radix Notoginseng, 25~30 parts of Resina Draconis.
Preferred as one, described treatment vasculitis is festered, the Chinese medicine for outer use of gangrene is prepared from by the raw material that comprises following weight portion: 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis.
In formula of the present invention, Cortex Phellodendri, meridian distribution of property and flavor: bitter, cold; Return kidney, bladder, large intestine channel; Effect: heat clearing and damp drying, eliminating fire and detoxication, bring down a fever except steam.Cortex Pseudolaricis, nature and flavor, warm in nature, acrid in the mouth; Poisonous; Function cures mainly: parasite killing, and antipruritic, for scabies pruritus.Fructus Cnidii, nature and flavor: warm in nature, acrid in the mouth, hardship; Function cures mainly: warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.Galla Chinensis, have and astringe the lung, astringing intestine to stop diarrhea, hemostasis, removing toxic substances and astriction, because wherein contained tannic acid has precipitation to protein, after skin, mucosa, ulcer contact tannic acid, its tissue protein is solidified, and causes one deck tunicle and is astriction, simultaneously also oppressed contraction of little blood vessel, blood clotting and hemostasia effect.Myrrha, is used for the treatment of the diseases such as traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula and diseases of the eye.Olibanum, property acrid, bitter, warm, enters the heart, liver, spleen channel; Invigorate blood circulation, circulation of qi promoting, pain relieving.Radix Ilicis Pubescentis, mildly bitter flavor is sweet, and property is flat, nontoxic; Heat-clearing and toxic substances removing, blood circulation and channel invigorating; Control thromboangiitis obliterans, erysipelas, scalds central serous chorioretinopathy, uveitis, and skin acute suppurative inflammation; For blood post thromboangiitis obliterans.Radix Notoginseng, is just acknowledged as since ancient times and has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Li Shizhen (1518-1593 A.D.) thinks that in Compendium of Material Medica Radix Notoginseng can control all disorders of blood, and " book on Chinese herbal medicine is newly organized " records that " Radix Notoginseng, the refreshing medicine of hemostasis also.The no matter blood of upper, middle and lower, all have an outer more person, private also effect simply, be incorporated in enrich blood, more refreshing in Qi-tonifying drug ".Resina Draconis is conventional precious Chinese medicine, and it has effect of antiinflammatory, hemostasia and promoting granulation, eliminating stasis to stop pain, and for the treatment of the various mass formed by blood stasis of Chinese medicine, through clinical proof, to fracture, soft tissue injury and hemoptysis, hematemesis be too much etc., multiple mass formed by blood stasis has good curative effect for it.
For solving above-mentioned second technical problem, technical scheme of the present invention is:
Treat that vasculitis is festered, the preparation method of Chinese medicine for outer use for gangrene, comprise the following steps:
(1) by weight, after the crude drug that comprises 15~20 parts of Cortex Phellodendris, 20~30 parts of Cortex Pseudolariciss, 20~30 parts of Fructus Cnidiis, 35~40 parts of Galla Chinensiss, 5~10 parts of Myrrhas, 5~10 parts of Olibanums, 15~20 parts of Radix Ilicis Pubescentiss, 25~30 parts of Radix Notoginseng, 25~30 parts of Resina Draconis is pulverized, is mixed, add the water heating and refluxing extraction 1.5~2.5 hours of 7~9 times of weight of described crude drug, filter and obtain respectively medicinal liquid and medicinal residues.
(2), in the medicinal residues that obtain in step (1), add the water of 5~7 times of weight of described medicinal residues, heating and refluxing extraction 1.5~2.5 hours, the medicinal liquid that the medicinal liquid that filtration obtains and step (1) obtain merges, and being then concentrated into density is 1.05~1.1g/cm 3.
(3) in above-mentioned concentrated solution, add ethanol, place and more than 24 hours draw supernatant, then after the separation of ethanol in supernatant being reclaimed, obtain Chinese medicine stock solution, it is 50~60wt% that described Chinese medicine stock solution adding distil water is adjusted to middle concentration, then stirs, fill after fine straining, sealing obtains medical treatment, and vasculitis is festered, the Chinese medicine preparation of gangrenous use.
Preferred as one, described crude drug comprises 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis.
Preferably, in step (3), in concentrated solution, adding ethanol and regulating ethanol content is 70~75wt%.
Preferably, in step (3), it is 50~60wt% that Chinese medicine stock solution adding distil water is adjusted to middle concentration, then circulation stirring 0.5~1 hour, and fill after fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous use.
The present invention is liquor, and external spreads upon affected part Transdermal absorption, every day two to five times, penetrates the through focus of subcutaneous active drug, and establishment side branch vessel replaces downright bad blood vessel, increases blood circulation, makes foci disappearance, and new flesh produces.The present invention coordinates electromagnetic therapeutic apparatus to use (as contained grand electromagnetic therapeutic apparatus) effect better, adopts " two-way one is saturating " therapy, and two-way is the meridian dredging, venting QI-blood.One is transdermal administration thoroughly.The electromagnetism of this therapy, electric heating, far infrared, strong saturatingization, medicine gas particle imports far infrared wave, electromagnetic wave, the strong saturatingization ripple that five functional produces, and lesion vessels is recovered and expanded, venting QI-blood, the meridian dredging; Penetrate the through focus of subcutaneous active drug, establishment side branch vessel replaces downright bad blood vessel, increases blood circulation, makes foci disappearance, and new flesh produces.This is to cure the effective therapy of vasculitis, is also medical science one important breakthrough.
Owing to having adopted technique scheme, the invention has the beneficial effects as follows:
Chinese medicine preparation of the present invention adopts and comprises 15~20 parts of Cortex Phellodendris, 20~30 parts of Cortex Pseudolariciss, 20~30 parts of Fructus Cnidiis, 35~40 parts of Galla Chinensiss, 5~10 parts of Myrrhas, 5~10 parts of Olibanums, 15~20 parts of Radix Ilicis Pubescentiss, 25~30 parts of Radix Notoginseng, the crude drug that Resina Draconis is 25~30 parts is prepared from, adopt rational formula and proportioning, the treatment of Transdermal absorption therapy, penetrate the through focus of subcutaneous active drug, patient's absorption and therapeutic effect are good, cure rate is high, the patient who is much on the verge of amputation is saved, recover health, the maximum feature of this Therapeutic Method is: dose is few, instant effect, short treating period, expense is low, do not have an injection, do not take medicine, not amputation.
The present invention uses simply, and economical, convenient, and the wounded need not be in hospital, and is beneficial to and applies.
The specific embodiment
Further set forth the present invention below in conjunction with specific embodiment.
Embodiment 1
By weight, after the crude drug that comprises 15 parts of Cortex Phellodendris, 20 parts of Cortex Pseudolariciss, 20 parts of Fructus Cnidiis, 35 parts of Galla Chinensiss, 5 parts of Myrrhas, 5 parts of Olibanums, 15 parts of Radix Ilicis Pubescentiss, 25 parts of Radix Notoginseng, 25 parts of Resina Draconis is pulverized, is mixed, add the water heating and refluxing extraction 1.5 hours of 7 times of weight of described crude drug, filter and obtain respectively medicinal liquid and medicinal residues.
In medicinal residues obtained above, add the water of 5 times of weight of described medicinal residues, heating and refluxing extraction 1.5 hours, filters the medicinal liquid obtaining and merges with the medicinal liquid that reflux obtains for the first time, and being then concentrated into density is 1.05g/cm 3.
In above-mentioned concentrated solution, add ethanol, adjusting ethanol content is 70wt%, place and within 24 hours, draw supernatant, then after the ethanol in supernatant being taked separated to reclaim, obtain Chinese medicine stock solution, it is 50wt% that described Chinese medicine stock solution adding distil water is adjusted to middle concentration, then circulation stirring 0.5 hour, and fill after fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous use.
Embodiment 2
By weight, after the crude drug that comprises 20 parts of Cortex Phellodendris, 30 parts of Cortex Pseudolariciss, 30 parts of Fructus Cnidiis, 40 parts of Galla Chinensiss, 10 parts of Myrrhas, 10 parts of Olibanums, 20 parts of Radix Ilicis Pubescentiss, 30 parts of Radix Notoginseng, 30 parts of Resina Draconis is pulverized, is mixed, add the water heating and refluxing extraction 2.5 hours of 9 times of weight of described crude drug, filter and obtain respectively medicinal liquid and medicinal residues.
In medicinal residues obtained above, add the water of 7 times of weight of described medicinal residues, heating and refluxing extraction 2.5 hours, filters the medicinal liquid obtaining and merges with the medicinal liquid that reflux obtains for the first time, and being then concentrated into density is 1.1g/cm 3.
In above-mentioned concentrated solution, add ethanol, adjusting ethanol content is 75wt%, place and within 28 hours, draw supernatant, then after the separation of ethanol in supernatant being reclaimed, obtain Chinese medicine stock solution, it is 60wt% that described Chinese medicine stock solution adding distil water is adjusted to middle concentration, then circulation stirring 0.8 hour, and fill after fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous use.
Embodiment 3
By weight, after the crude drug that comprises 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis is pulverized, is mixed, add the water heating and refluxing extraction 2 hours of 8 times of weight of described crude drug, filter and obtain respectively medicinal liquid and medicinal residues.
In medicinal residues obtained above, add the water of 6 times of weight of described medicinal residues, heating and refluxing extraction 2 hours, filters the medicinal liquid obtaining and merges with the medicinal liquid that reflux obtains for the first time, and being then concentrated into density is 1.08g/cm 3.
In above-mentioned concentrated solution, add ethanol, adjusting ethanol content is 72wt%, place and within 24 hours, draw supernatant, then after the separation of ethanol in supernatant being reclaimed, obtain Chinese medicine stock solution, it is 55wt% that described Chinese medicine stock solution adding distil water is adjusted to middle concentration, then circulation stirring 1 hour, and fill after fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous use.
The present invention, through the treatment to 80 routine patients, proves that medication dose is few, instant effect, and short treating period, expense is low, does not have an injection, do not take medicine, not amputation, and curative effect is good, has good value for applications.Model case is as follows:
Case 1
Ma Zhankui, man, 60 years old, retired worker, is diagnosed as vasculitis through Wei Yi Affiliated Hospital, can not walk, left lower extremity blackout, fester in ankle place, once in large hospital treatments such as Shandong hospital, province's traditional Chinese medical science, all without obvious curative effects, and cannot effect a radical cure, after receive treatment to company in May, 2012, use that the treatment vasculitis prepared of the present invention is festered, the Chinese medicine preparation of gangrenous use is smeared affected part, after treatment, the rotten position healing of forming a scab very soon returns to one's perfect health after the treatment of month.
Case 2
Li Xia, female, 28 years old, shop worker, through Jining, the People's Hospital is diagnosed as vasculitis, right lower extremity blackout, do not occur festering, introduce by media, come company in June, 2012 and receive treatment, the treatment vasculitis that uses the present invention to prepare is festered, the Chinese medicine preparation of gangrenous use is smeared affected part, one day twice, to treat after the 6th day, blackout place starts variable color, approach normal color, recovery from illness in 15 days.
Case 3
Liu Hua, female, 40 years old, rural women, through Anqiu, the People's Hospital is diagnosed as vasculitis, both legs lower limb blackout, and start to fester, in Anqiu, be in hospital half a year in the People's Hospital, by fighting in the van, the antiinflammatory pin such as cephalo, to no effect, after at home with a cubic metre of earth treatment, through multi-treatment to no effect, the affected part inflammation of having festered, after being introduced, in June, 2012, company receives treatment, and the treatment vasculitis that uses the present invention to prepare is festered, the Chinese medicine preparation of gangrenous use is smeared affected part, every day three times, treat recovery from illness one month.
Case 4
Wang Wenfeng, female, 33 years old, through Weifang, the People's Hospital was diagnosed as vasculitis, and lower limb calf has redness, and the hurt like hell of walking, through treating also without obvious curative effects.In in August, 2012 company's treatment, the treatment vasculitis that uses the present invention to prepare is festered, the Chinese medicine preparation of gangrenous use is smeared affected part, and less than recovery from illness after the course for the treatment of (20 days), red and swollen, pain disappears entirely.
Case 5
Liu Xiaoli, man, 32 years old, peasant, the difficulty of walking, both legs and foot blackout is festered, various big hospital in Zeng Quguo Beijing 301 Hospital and Shandong Province, obstinate, is venous thrombosis through numerous hospital diagnosis, worsens as gangrene, consensus is wanted his amputation of performing the operation.Come company through the treatment of a month course for the treatment of in JIUYUE, 2012, the treatment vasculitis that uses the present invention to prepare is festered, the Chinese medicine preparation of gangrenous use is smeared affected part, and more than three times, fully recovered every day, also can normally walk.

Claims (6)

1. treat vasculitis fester, gangrene a Chinese medicine for outer use, it is characterized in that being prepared from by the raw material of following weight portion: 15~20 parts of Cortex Phellodendris, 20~30 parts of Cortex Pseudolariciss, 20~30 parts of Fructus Cnidiis, 35~40 parts of Galla Chinensiss, 5~10 parts of Myrrhas, 5~10 parts of Olibanums, 15~20 parts of Radix Ilicis Pubescentiss, 25~30 parts of Radix Notoginseng, 25~30 parts of Resina Draconis.
Treatment vasculitis as claimed in claim 1 fester, gangrene Chinese medicine for outer use, it is characterized in that being prepared from by the raw material of following weight portion: 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis.
3. treat that vasculitis is festered, the preparation method of Chinese medicine for outer use for gangrene, it is characterized in that comprising the following steps:
(1) by weight, after the crude drug that comprises 15~20 parts of Cortex Phellodendris, 20~30 parts of Cortex Pseudolariciss, 20~30 parts of Fructus Cnidiis, 35~40 parts of Galla Chinensiss, 5~10 parts of Myrrhas, 5~10 parts of Olibanums, 15~20 parts of Radix Ilicis Pubescentiss, 25~30 parts of Radix Notoginseng, 25~30 parts of Resina Draconis is pulverized, is mixed, add the water heating and refluxing extraction 1.5~2.5 hours of 7~9 times of weight of described crude drug, filter and obtain respectively medicinal liquid and medicinal residues;
(2), in the medicinal residues that obtain in step (1), add the water of 5~7 times of weight of described medicinal residues, heating and refluxing extraction 1.5~2.5 hours, the medicinal liquid that the medicinal liquid that filtration obtains and step (1) obtain merges, and being then concentrated into density is 1.05~1.1g/cm 3;
(3) in above-mentioned concentrated solution, add ethanol, place and more than 24 hours draw supernatant, then after the separation of ethanol in supernatant being reclaimed, obtain Chinese medicine stock solution, it is 50~60wt% that described Chinese medicine stock solution adding distil water is adjusted to middle concentration, then stirs, fill after fine straining, sealing obtains medical treatment, and vasculitis is festered, the Chinese medicine preparation of gangrenous use.
Treatment vasculitis as claimed in claim 3 fester, the preparation method of Chinese medicine for outer use of gangrene, it is characterized in that: described crude drug comprises 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis.
Treatment vasculitis as claimed in claim 3 fester, the preparation method of Chinese medicine for outer use of gangrene, it is characterized in that: in step (3), in concentrated solution, adding ethanol and regulating ethanol content is 70~75wt%.
Treatment vasculitis as claimed in claim 3 fester, the preparation method of Chinese medicine for outer use of gangrene, it is characterized in that: in step (3), it is 50~60wt% that Chinese medicine stock solution adding distil water is adjusted to middle concentration, then circulation stirring 0.5~1 hour, fill after fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous use.
CN201210447876.1A 2012-11-09 2012-11-09 External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene Active CN102895450B (en)

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