CN110151872A - It is a kind of for treating the Chinese medicine external side and its preparation method and application of vasculitis - Google Patents
It is a kind of for treating the Chinese medicine external side and its preparation method and application of vasculitis Download PDFInfo
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- CN110151872A CN110151872A CN201910395826.5A CN201910395826A CN110151872A CN 110151872 A CN110151872 A CN 110151872A CN 201910395826 A CN201910395826 A CN 201910395826A CN 110151872 A CN110151872 A CN 110151872A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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Abstract
The invention belongs to the field of Chinese medicines, disclose a kind of for treating the Chinese medicine external side and its preparation method and application of vasculitis.The Chinese medicine external side is prepared by following raw material according to the mass fraction: 1-3 parts of clerodendrum bungei leaf, 1-3 parts of Common Leafflower Herb, 1-3 parts of lutescent pycnospora herb.Chinese medicine compound prescription preparation of the present invention is convenient, formula rationally, plays mutually synergistic effect between raw material, curative for effect, although flavour of a drug only three tastes, but extraordinary effect can be but played for vasculitis, the through lesion of subcutaneous active drug is penetrated, patient absorbs and therapeutic effect is good, cure rate is high, it is uneasy to recur, to personal non-toxic, Small side effects.
Description
Technical field
It is the invention belongs to the field of Chinese medicines, in particular to a kind of for treating the Chinese medicine external side and preparation method thereof of vasculitis
And application.
Background technique
Vasculitis is the general name of peripheral angiopathy, because clinical symptoms caused by artery and vein obstruction are obstructed are vascular
Inflammation, including depth phlebitis, venous valvular incompetence, varication, atherosclerotic occlusive disease, chronic calf ulcer, glycosuria
The rotten foot of disease, erysipelas, Raynand's disease, the diseases such as aorto-arteritis.The cardinal symptom of vasculitis: suffering limb is sent out cool, cold, numb edema,
Pain is walked lamely on foot, and pain is aggravated with night, is lain awake all night.
Vasculitis is that a kind of artery and vein are all invaded, and is carried out slowly, the disease periodically aggravated, motherland's medicine is known as
" gangrene of finger or toe " " is sent out in toes, name says the gangrene of finger or toe, and shape is red black, stubbornly refuses to control, not black early in just on the books in the document in period in time immemorial
It is not dead "；The principle of reatment of " poison is then cut in meat, and poison has just been cut in finger " is carried in Tang's SUN Si miao supplement to Thousand Golden Prescriptions.It can be seen that China
This disease has just been recognized in ancient times, and until today, the disease is still persistent ailment, and without specific medicament, amputation disability rate is high, and blood vessel is taken
The features such as bridge operation and drug curing agent and interventional therapy, there is its limitation, and easy to recur, the often wound after amputation
Do not conform to, it is secondary, amputation also often occurs or even threat to life three times.
Atherosclerotic occlusive disease, in early days since arterial sclerosis, official jargon narrow, there are cold, fiber crops in blood circulation disorder
Wood, pedal skin is dry, and toe-end atrophoderma is hardened or muscular atrophy, and symptom can disappear after taking a momentary rest, after walking again
Still there is above-mentioned symptom.With the further development of the disease, suffering limb is cold, sends out exacerbation out of strength cool, and pain, Chu Weiyin occurs in night
It bitterly, is afterwards persistent ache, so that severe pain, severe pain is also one of main clinical manifestation of this disease.Normal duration severe pain forces patient
Bending knee is embraced foot or intersection point and is sat, and to mitigate pain, patient lies awake all night, apathetic, loss of appetite, lean and haggard, in chronic
Water pump face, such as necrosis phase be complicated by infection can with have a fever, convulsions of shivering, exhausting, stupor bacteremia or septicemia, physical examination
Suffering limb dorsalis pedis pulse is dynamic to disappear, and the cool, amyotrophia of foot, the colour of skin is pale, and ulcer or dry and wet occur in cyanosis or flush, livid purple, blackening
Necrosis.
Currently, traditional Chinese and western medicine has many drugs and method for the treatment of vasculitis, as operative treatment, vascular treatment method,
Gene therapy, immunization therapy, blood purification, Chinese medicinal decoction ball powder etc..Although existing treatment method respectively has feature and curative effect,
Cure rate is not satisfactory, and easy to recur after treatment, and toxic side effect is big.Therefore there is an urgent need to develop a kind of toxic side effect
It is small, cure rate is high, the drug for the treatment of vasculitis uneasy to recur.
Summary of the invention
In order to overcome shortcoming and deficiency existing in the prior art, the primary purpose of the present invention is that providing a kind of for controlling
Treat the Chinese medicine external side of vasculitis.
Another object of the present invention is to provide a kind of preparation method of above-mentioned Chinese medicine external side.
A further object of the present invention is to provide a kind of applications of above-mentioned Chinese medicine external side.
The object of the invention is achieved through the following technical solutions:
It is a kind of for treating the Chinese medicine external side of vasculitis, which is by following raw material according to the mass fraction
It is prepared: 1-3 parts of clerodendrum bungei leaf, 1-3 parts of Common Leafflower Herb, 1-3 parts of lutescent pycnospora herb.
The Chinese medicine external side is prepared by following fresh feed according to the mass fraction: 1 part of clerodendrum bungei leaf, Common Leafflower Herb
1 part, 1 part of lutescent pycnospora herb.
The preparation method of above-mentioned Chinese medicine external side, including following operating procedure: by fresh clerodendrum bungei leaf, Common Leafflower Herb and
After lutescent pycnospora herb removal of impurities processing, impurity is cleaned with 50 degree of pure rice wines, is voluntarily dried in the shade；Clerodendrum bungei leaf, Common Leafflower Herb and lutescent pycnospora herb after drying in the shade
Mixing, is ground into slurry with stainless steel pulverizer, adds 40-45g50 degree pure rice wine, stir evenly, and is stored in disinfection vial
It is spare.
Application of the above-mentioned Chinese medicine external side in preparation treatment vasculitis drug.
The application method of Chinese medicine external side of the present invention: Chinese medicine external recipe slurry is taken directly to spread on affected part, with antiseptic gauze packet
It pricks and fixes, apply 10-12h daily, if occurring the case where medicine slurry overdrying during the topical application of drug, in time toward spraying wine on powder, whole process
Keep wet, in order to avoid influence drug effect.
The principle of the present invention is:
Clerodendrum bungei leaf: property and flavor of peppery and warm.Return heart, stomach, large intestine channel.There is the effect of promoting blood circulation to remove blood stasis, subdhing swelling and detoxicating.Cure mainly carbuncle
Subcutaneous ulcer, furunculosis, mazoitis, arthritis, eczema, toothache, hemorrhoid and rectal prolapse.
Common Leafflower Herb: nature and flavor are sweet, cool, slight bitter.Returns spleen, lung channel.There is the effect of reducing fever and causing diuresis, improving eyesight, disperse accumulation.Cure mainly ephritis
Oedema, urinary infection, calculus, enteritis, dysentery, aphtha, infantile malnutrition.
Lutescent pycnospora herb: nature and flavor are light, cool.Distributed in heart and lung channels.There is the effect of promoting diuresis for stranguria, eliminating stasis to subdue swelling.Cure mainly uropoiesis tying
Stone is beaten the stasis of blood swell, traumatic hemorrhage.
Compared with prior art, the present invention has the following advantages and beneficial effects: Chinese medicine external side's preparation of the present invention is convenient,
Formula rationally, plays mutually synergistic effect between raw material, curative for effect, although flavour of a drug only three tastes, is directed to vasculitis
But extraordinary effect can be played, penetrates the through lesion of subcutaneous active drug, patient absorbs and therapeutic effect is good, cure rate
Height, it is uneasy to recur, to personal non-toxic, Small side effects.Three taste medicinal materials in invention formulation are indispensable, and treatment vasculitis has
Efficiency reaches 100%, and cure rate reaches 99%, uneasy to recur；Flavour of a drug are few, to personal non-toxic, Small side effects.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
Embodiment 1
It is a kind of for treating the Chinese medicine external side of vasculitis, which is by following according to the mass fraction fresh
Raw material is prepared: 1 part of clerodendrum bungei leaf, 1 part of Common Leafflower Herb, 1 part of lutescent pycnospora herb.It is specifically prepared according to the following steps: will be fresh smelly
After peony leaves, Common Leafflower Herb and lutescent pycnospora herb removal of impurities processing, impurity is cleaned with 50 degree of pure rice wines, is voluntarily dried in the shade；Clerodendrum bungei leaf after drying in the shade,
Common Leafflower Herb and lutescent pycnospora herb mixing, are ground into slurry with stainless steel pulverizer, add 40-45g50 degree pure rice wine, stir evenly, store
It is spare in disinfection vial.
Embodiment 2
It is a kind of for treating the Chinese medicine external side of vasculitis, which is by following raw material according to the mass fraction
It is prepared: 2 parts of clerodendrum bungei leaf, 3 parts of Common Leafflower Herb, 3 parts of lutescent pycnospora herb.It is specifically prepared according to the following steps: by fresh clerodendrum bungei
After leaf, Common Leafflower Herb and lutescent pycnospora herb removal of impurities processing, impurity is cleaned with 50 degree of pure rice wines, is voluntarily dried in the shade；After drying in the shade under clerodendrum bungei leaf, leaf
Pearl and lutescent pycnospora herb mixing, are ground into slurry with stainless steel pulverizer, add 40-45g50 degree pure rice wine, stir evenly, be stored in and disappear
It is spare in malicious vial.
Embodiment 3
It is a kind of for treating the Chinese medicine external side of vasculitis, which is by following raw material according to the mass fraction
It is prepared: 3 parts of clerodendrum bungei leaf, 2 parts of Common Leafflower Herb, 1 part of lutescent pycnospora herb.It is specifically prepared according to the following steps: by fresh clerodendrum bungei
After leaf, Common Leafflower Herb and lutescent pycnospora herb removal of impurities processing, impurity is cleaned with 50 degree of pure rice wines, is voluntarily dried in the shade；After drying in the shade under clerodendrum bungei leaf, leaf
Pearl and lutescent pycnospora herb mixing, are ground into slurry with stainless steel pulverizer, add 40-45g50 degree pure rice wine, stir evenly, be stored in and disappear
It is spare in malicious vial.
Effect example 1:
Treatment object: being diagnosed as vasculitis patient, and totally 200, male 120, women 80, the age 30-60 years old.
Treatment method: treatment object is treated by 1 gained Chinese medicine external side of embodiment；Take Chinese medicine external recipe slurry straight
It connects and spreads on affected part, wrapped up and fixed with antiseptic gauze, 10-12h is continuously applied daily, if occurring medicine slurry overdrying during the topical application of drug
Situation, in time toward wine is sprayed on powder, whole process keeps wet, in order to avoid influence drug effect, the course for the treatment of is 45 days.
Curative effect judging standard:
Clinical cure: clinical symptoms all disappear, and the limbs surface of a wound heals completely, distal limb blood circulation disorder and impedance
Formula blood figure is obviously improved；
Effective: clinical symptom relief, the state of an illness are controlled, and the limbs surface of a wound is close to healing or reduces, and distal limb blood follows
Ring and blood figure slightly improve；
Invalid: clinical symptoms are without being clearly better or continue to aggravate.
Treatment results: 200 vasculitis patients in experimental group cure 198, effective 2, invalid 0.
Follow-up is carried out to the patient of healing after 1 year and checks chemical examination, recurrence rate is only 2.5%.
Effect example 2:
Ma, male, 58 years old, suffers from varication 6 years, and the blood vessel of two leg varicoses is uneven, and skin turgor has picotement, acid
Pain, hectic fever；When more on foot, leg swelling, numbness.Because fearing operation, external application side of the present invention is attempted.With 1 gained of the embodiment of the present invention
Chinese medicine external recipe slurry directly spreads on affected part, is wrapped up and is fixed with antiseptic gauze, deposited 10-12h continuous daily, if in topical application of drug process
In there is the case where medicine slurry overdrying, in time toward wine is sprayed on powder, whole process keeps wet, in order to avoid influence drug effect, swelling ache after 8 days
Symptom mitigates, and is calmed down with skin after 40 days, and swelling, numbness, ache disappear, and continues to use 15 days and consolidates curative effect, until thorough rehabilitation.
Follow-up is without recurrence after half a year.
Effect example 3:
Hu, female, 39 years old, double lower limb blacked, and started to fester, come before examining by fighting in the van, the anti-inflammatory needle such as cephalo it is invalid.
Affected part is directly spread on 2 gained Chinese medicine external recipe of embodiment of the present invention slurry, is wrapped up and is fixed with antiseptic gauze, it is continuous daily to apply
10-12h, if occurring the case where medicine slurry overdrying during the topical application of drug, in time toward wine is sprayed on powder, whole process keeps moistening, in order to avoid
Drug effect is influenced, symptom mitigates after 5 days, and wound gradually heals, pain relief, is healed substantially with rotten position after 20 days, after 30 days
Rotten position heals completely, continues to use 15 days and consolidates curative effect.Follow-up is without recurrence after half a year.
Effect example 4:
Wu, male, 43 years old, is diagnosed as phlebitis, lower limb calf has redness, in great pain on foot, obstinate.With this
3 gained Chinese medicine external recipe of inventive embodiments slurry directly spreads on affected part, is wrapped up and is fixed with antiseptic gauze, deposited 10- continuous daily
12h, if occurring the case where medicine slurry overdrying during the topical application of drug, in time toward wine is sprayed on powder, whole process keeps wet, in order to avoid influence
Drug effect, swelling symptom mitigates after 10 days, and pain makes moderate progress, and is completely disappeared, is continued to use with red and swollen and pain symptom after 30 days
Consolidate curative effect within 20 days.Follow-up is without recurrence after half a year.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (4)
1. a kind of for treating the Chinese medicine external side of vasculitis, it is characterised in that: the Chinese medicine external side is by below by mass parts
The fresh feed of number meter is prepared: 1-3 parts of clerodendrum bungei leaf, 1-3 parts of Common Leafflower Herb, 1-3 parts of lutescent pycnospora herb.
2. according to claim 1 a kind of for treating the Chinese medicine external side of vasculitis, it is characterised in that: the Chinese medicine external
Side is prepared by following fresh feed according to the mass fraction: 1 part of clerodendrum bungei leaf, 1 part of Common Leafflower Herb, 1 part of lutescent pycnospora herb.
3. the preparation method of Chinese medicine external side according to claim 1, it is characterised in that including following operating procedure: will be new
After fresh clerodendrum bungei leaf, Common Leafflower Herb and lutescent pycnospora herb removal of impurities is handled, impurity is cleaned with 50 degree of pure rice wines, is voluntarily dried in the shade；It is smelly after drying in the shade
Peony leaves, Common Leafflower Herb and lutescent pycnospora herb mixing, are ground into slurry with stainless steel pulverizer, add 40-45g50 degree pure rice wine, and stirring is equal
It is even, it is stored in spare in disinfection vial.
4. application of the Chinese medicine external side according to claim 1 in preparation treatment vasculitis drug.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910395826.5A CN110151872A (en) | 2019-05-13 | 2019-05-13 | It is a kind of for treating the Chinese medicine external side and its preparation method and application of vasculitis |
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| CN201910395826.5A CN110151872A (en) | 2019-05-13 | 2019-05-13 | It is a kind of for treating the Chinese medicine external side and its preparation method and application of vasculitis |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895450A (en) * | 2012-11-09 | 2013-01-30 | 山东盛宏医药科技有限公司 | External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene |
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- 2019-05-13 CN CN201910395826.5A patent/CN110151872A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895450A (en) * | 2012-11-09 | 2013-01-30 | 山东盛宏医药科技有限公司 | External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene |
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Application publication date: 20190823 |
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