CN102895450A - External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene - Google Patents
External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene Download PDFInfo
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Abstract
The invention discloses an external Chinese herbal preparation for treating angiitis fester and gangrene and a method for preparing the external Chinese herbal preparation for treating angiitis fester and gangrene. The method comprises the following steps that: (1) the active pharmaceutical ingredients including 15-20 parts of amur cork tree bark, 20-30 parts of cortex pseudolaricis, 20-30 parts of fructus cnidii, 35-40 parts of Chinese gall, 5-10 parts of myrrha, 5-10 parts of frankincense, 15-20 parts of pubescent holly root, 25-30 parts of radix notoginseng and 25-30 parts of sanguis draconis are ground and mixed, are then added with water to be refluxed and extracted and are finally filtered to respectively obtain pharmaceutical liquid and pharmaceutical residues, the pharmaceutical residues are added with water to be refluxed and extracted, the obtained pharmaceutical liquid after two times of filtration are mixed and concentrated, and the original Chinese herbal liquid is obtained through ethanol, is added with distilled water to be diluted and is mixed and finely filtered to be filled and sealed, so that the Chinese herbal preparation for treating angiitis fester and gangrene is obtained. The external Chinese herbal preparation is reasonable in compound and ratio and treats under the cooperation of a percutaneous absorption therapy, the active pharmaceutical ingredients which subcutaneously permeate can directly reach focuses, so that good absorption and curative effects are realized for patients, and the curative ratio is high.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind ofly treat that vasculitis is festered, the Chinese medicine for outer use and preparation method thereof of gangrene.
Background technology
Vasculitis is tremulous pulse and vein blood vessel inflammation, so tremulous pulse and the obstructed clinical symptoms that causes of vein obstruction are vasculitis.Vasculitis is festered, the treatment of gangrene for treating both at home and abroad at present, the common purpose that adopts oral anti-inflammatory drug or have an intravenous drip to reach antiinflammatory, but because vasculitis patient's blood vessel blockage can't make the effective medicine of capacity arrive focus, therefore cause the poor and medical expense height of therapeutic effect; For severe patient, adopt the method for amputation more, cause suffering and deformity to the patient.Above method, its curative effect is all undesirable.
Summary of the invention
First technical problem to be solved by this invention is: for the deficiency that prior art exists, provide a kind of and make that dosage is few, instant effect, short treating period, medical expense are low, do not have an injection, do not take medicine, not amputation and treatment vasculitis easy to use is festered, the Chinese medicine for outer use of gangrene.
Second technical problem to be solved by this invention is: for the deficiency that prior art exists, provide a kind of and make that dosage is few, instant effect, short treating period, medical expense are low, do not have an injection, do not take medicine, not amputation and treatment vasculitis easy to use is festered, the preparation method of the Chinese medicine for outer use of gangrene.
For solving above-mentioned first technical problem, technical scheme of the present invention is:
A kind of treat vasculitis fester, the gangrene Chinese medicine for outer use, be prepared from by the raw material that comprises following weight portion: 15～20 parts of Cortex Phellodendris, 20～30 parts of Cortex Pseudolariciss, 20～30 parts of Fructus Cnidiis, 35～40 parts of Galla Chinensiss, 5～10 parts of Myrrhas, 5～10 parts of Olibanums, 15～20 parts of Radix Ilicis Pubescentiss, 25～30 parts of Radix Notoginseng, 25～30 parts of Resina Draconis.
As a kind of preferred, described treatment vasculitis is festered, the Chinese medicine for outer use of gangrene is prepared from by the raw material that comprises following weight portion: 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis.
In the prescription of the present invention, Cortex Phellodendri, meridian distribution of property and flavor: bitter, cold; Return kidney, bladder, large intestine channel; Effect: heat clearing and damp drying, eliminating fire and detoxication, bring down a fever except steaming.Cortex Pseudolaricis, nature and flavor, warm in nature, acrid in the mouth; Poisonous; Function cures mainly: parasite killing, and antipruritic, be used for the scabies pruritus.Fructus Cnidii, nature and flavor: warm in nature, acrid in the mouth, hardship; Function cures mainly: warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Galla Chinensis, have and astringe the lung, astringing intestine to stop diarrhea, hemostasis, detoxifcation and astriction, because wherein contained tannic acid has precipitation to protein, behind skin, mucosa, the ulcer contact tannic acid, its tissue protein namely is solidified, and causes one deck tunicle and is astriction, simultaneously also oppressed contraction of little blood vessel, blood clotting and hemostasia effect.Myrrha is used for the treatment of the diseases such as traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula and diseases of the eye.Olibanum, property is hot, bitter, warm, enters the heart, liver, spleen channel; Invigorate blood circulation, circulation of qi promoting, pain relieving.Radix Ilicis Pubescentis, mildly bitter flavor is sweet, and property is flat, and is nontoxic; Heat-clearing and toxic substances removing, blood circulation and channel invigorating; Control thromboangiitis obliterans, erysipelas is scalded central serous chorioretinopathy, uveitis, and skin acute suppurative inflammation; Be used for blood post thromboangiitis obliterans.Radix Notoginseng just is acknowledged as since ancient times and has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Li Shizhen (1518-1593 A.D.) thinks that in Compendium of Material Medica Radix Notoginseng can control all disorders of blood, and " book on Chinese herbal medicine is newly organized " " Radix Notoginseng, the refreshing medicine of hemostasis also in record.The blood of upper, middle and lower no matter, all have an outer more person, private also effect simply, be incorporated in enrich blood, then more refreshing in the Qi-tonifying drug ".Resina Draconis is the precious Chinese medicine of commonly using, and it has the effect of antiinflammatory, hemostasia and promoting granulation, eliminating stasis to stop pain, is used for the treatment of the various mass formed by blood stasis of Chinese medicine, and through clinical proof, it has good curative effect to multiple mass formed by blood stasis such as fracture, soft tissue injury and hemoptysis, hematemesis are too much.
For solving above-mentioned second technical problem, technical scheme of the present invention is:
A kind ofly treat that vasculitis is festered, the preparation method of Chinese medicine for outer use of gangrene, may further comprise the steps:
(1) by weight, after the crude drug that will comprise 15～20 parts of Cortex Phellodendris, 20～30 parts of Cortex Pseudolariciss, 20～30 parts of Fructus Cnidiis, 35～40 parts of Galla Chinensiss, 5～10 parts of Myrrhas, 5～10 parts of Olibanums, 15～20 parts of Radix Ilicis Pubescentiss, 25～30 parts of Radix Notoginseng, 25～30 parts of Resina Draconis is pulverized, is mixed, the water heating and refluxing extraction 1.5～2.5 hours that adds 7～9 times of weight of described crude drug is filtered and is obtained respectively medicinal liquid and medicinal residues.
(2) in the medicinal residues that step (1) obtains, add the water of 5～7 times of weight of described medicinal residues, heating and refluxing extraction 1.5～2.5 hours, the medicinal liquid that the medicinal liquid that filtration obtains and step (1) obtain merges, and then being concentrated into density is 1.05～1.1g/cm
3
(3) in above-mentioned concentrated solution, add ethanol, place and draw supernatant more than 24 hours, then after the separation of ethanol in the supernatant being reclaimed, obtain Chinese medicine stock solution, it is 50～60wt% that described Chinese medicine stock solution adding distil water is transferred to middle concentration, then stirs, fill behind the fine straining, sealing obtains medical treatment, and vasculitis is festered, the Chinese medicine preparation of gangrenous usefulness.
As a kind of preferred, described crude drug comprises 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis.
Preferably, in the step (3), adding ethanol and regulate ethanol content in concentrated solution is 70～75wt%.
Preferably, in the step (3), it is 50～60wt% that Chinese medicine stock solution adding distil water is transferred to middle concentration, and then circulation stirring is 0.5～1 hour, and fill behind the fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous usefulness.
The present invention is liquor, and external spreads upon the affected part Transdermal absorption, penetrates the through focus of subcutaneous active drug every day two to five times, and the establishment side branch vessel replaces downright bad blood vessel, increases blood circulation, makes foci disappearance, and new flesh produces.The present invention cooperates electromagnetic therapeutic apparatus to use (as containing grand electromagnetic therapeutic apparatus) effect better, adopts " two-way one is saturating " therapy, and two-way is the meridian dredging, venting QI-blood.One is transdermal administration thoroughly.The electromagnetism of this therapy, electric heating, far infrared, strong saturatingization, medicine gas particle imports far infrared wave, electromagnetic wave, the strong saturatingization ripple that five functional produces, and lesion vessels is recovered and expanded, venting QI-blood, the meridian dredging; Penetrate the through focus of subcutaneous active drug, the establishment side branch vessel replaces downright bad blood vessel, increases blood circulation, makes foci disappearance, and new flesh produces.This is to cure the effective therapy of vasculitis, also is medical science one important breakthrough.
Owing to adopted technique scheme, the invention has the beneficial effects as follows:
Chinese medicine preparation of the present invention adopts and comprises 15～20 parts of Cortex Phellodendris, 20～30 parts of Cortex Pseudolariciss, 20～30 parts of Fructus Cnidiis, 35～40 parts of Galla Chinensiss, 5～10 parts of Myrrhas, 5～10 parts of Olibanums, 15～20 parts of Radix Ilicis Pubescentiss, 25～30 parts of Radix Notoginseng, the crude drug that Resina Draconis is 25～30 parts is prepared from, adopt rational formula and proportioning, the treatment of Transdermal absorption therapy, penetrate the through focus of subcutaneous active drug, patient's absorption and therapeutic effect are good, cure rate is high, the patient who much is on the verge of amputation is saved, recovered health, the maximum characteristics of this Therapeutic Method are: dose is few, instant effect, short treating period, expense is low, does not have an injection, do not take medicine not amputation.
The present invention uses simply, and economical, convenient, and the wounded need not be in hospital, and is beneficial to and applies.
The specific embodiment
Further set forth the present invention below in conjunction with specific embodiment.
Embodiment 1
By weight, after the crude drug that will comprise 15 parts of Cortex Phellodendris, 20 parts of Cortex Pseudolariciss, 20 parts of Fructus Cnidiis, 35 parts of Galla Chinensiss, 5 parts of Myrrhas, 5 parts of Olibanums, 15 parts of Radix Ilicis Pubescentiss, 25 parts of Radix Notoginseng, 25 parts of Resina Draconis is pulverized, is mixed, the water heating and refluxing extraction 1.5 hours that adds 7 times of weight of described crude drug is filtered and is obtained respectively medicinal liquid and medicinal residues.
In medicinal residues obtained above, add the water of 5 times of weight of described medicinal residues, heating and refluxing extraction 1.5 hours is filtered the medicinal liquid that obtains and the medicinal liquid that the first time, reflux obtained and is merged, and then being concentrated into density is 1.05g/cm
3
In above-mentioned concentrated solution, add ethanol, the adjusting ethanol content is 70wt%, place and drew supernatant in 24 hours, then after the ethanol in the supernatant being taked separated to reclaim, obtain Chinese medicine stock solution, it is 50wt% that described Chinese medicine stock solution adding distil water is transferred to middle concentration, and then circulation stirring is 0.5 hour, and fill behind the fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous usefulness.
Embodiment 2
By weight, after the crude drug that will comprise 20 parts of Cortex Phellodendris, 30 parts of Cortex Pseudolariciss, 30 parts of Fructus Cnidiis, 40 parts of Galla Chinensiss, 10 parts of Myrrhas, 10 parts of Olibanums, 20 parts of Radix Ilicis Pubescentiss, 30 parts of Radix Notoginseng, 30 parts of Resina Draconis is pulverized, is mixed, the water heating and refluxing extraction 2.5 hours that adds 9 times of weight of described crude drug is filtered and is obtained respectively medicinal liquid and medicinal residues.
In medicinal residues obtained above, add the water of 7 times of weight of described medicinal residues, heating and refluxing extraction 2.5 hours is filtered the medicinal liquid that obtains and the medicinal liquid that the first time, reflux obtained and is merged, and then being concentrated into density is 1.1g/cm
3
In above-mentioned concentrated solution, add ethanol, the adjusting ethanol content is 75wt%, place and drew supernatant in 28 hours, then after the separation of ethanol in the supernatant being reclaimed, obtain Chinese medicine stock solution, it is 60wt% that described Chinese medicine stock solution adding distil water is transferred to middle concentration, and then circulation stirring is 0.8 hour, and fill behind the fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous usefulness.
Embodiment 3
By weight, after the crude drug that will comprise 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis is pulverized, is mixed, the water heating and refluxing extraction 2 hours that adds 8 times of weight of described crude drug is filtered and is obtained respectively medicinal liquid and medicinal residues.
In medicinal residues obtained above, add the water of 6 times of weight of described medicinal residues, heating and refluxing extraction 2 hours is filtered the medicinal liquid that obtains and the medicinal liquid that the first time, reflux obtained and is merged, and then being concentrated into density is 1.08g/cm
3
In above-mentioned concentrated solution, add ethanol, the adjusting ethanol content is 72wt%, place and drew supernatant in 24 hours, then after the separation of ethanol in the supernatant being reclaimed, obtain Chinese medicine stock solution, it is 55wt% that described Chinese medicine stock solution adding distil water is transferred to middle concentration, and then circulation stirring is 1 hour, and fill behind the fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous usefulness.
The present invention proves that through the treatment to 80 routine patients the medication dose is few, instant effect, and short treating period, expense is low, does not have an injection, do not take medicine, not amputation, and curative effect is good, has good value for applications.Model case is as follows:
Case 1
Ma Zhankui, man, 60 years old, the retired worker is diagnosed as vasculitis through Weihe River doctor Affiliated Hospital, can not walk, the left lower extremity blackout, fester in the ankle place, once in large hospital treatments such as Shandong hospital, province's traditional Chinese medical science, all without obvious curative effects, and can't effect a radical cure, to receive treatment to company in May, 2012 afterwards, the treatment vasculitis of using the present invention to prepare is festered, the Chinese medicine preparation of gangrenous usefulness is smeared the affected part, the very fast incrustation healing of rotten position after the treatment is through returning to one's perfect health after one month the treatment.
Case 2
Li Xia, woman, 28 years old, the workshop workman, the People's Hospital is diagnosed as vasculitis through Jining, the right lower extremity blackout, do not occur festering, by the media introduction, come company in June, 2012 and receive treatment, the treatment vasculitis of using the present invention to prepare is festered, the Chinese medicine preparation of gangrenous usefulness is smeared the affected part, one day twice, treat the 6th day after, the blackout place begins variable color, near normal color, recovery from illness in 15 days.
Case 3
Liu Hua, woman, 40 years old, rural women, the People's Hospital is diagnosed as vasculitis through Anqiu, both legs lower limb blackout, and begin to fester, be in hospital half a year in the People's Hospital in Anqiu, by fight in the van, the antiinflammatory pin such as cephalo, to no effect, after at home with a cubic metre of earth treatment, through multi-treatment to no effect, the affected part inflammation of having festered, after upon somebody's introduction, company receives treatment in June, 2012, uses the treatment vasculitis of the present invention's preparation to fester, the Chinese medicine preparation of gangrenous usefulness smears the affected part, every day three times, treated recovery from illness one month.
Case 4
Wang Wenfeng, the woman, 33 years old, the People's Hospital was diagnosed as vasculitis through Weifang, and the lower limb calf has redness, and the hurt like hell of walking is through treating also without obvious curative effects.In in August, 2012 company's treatment, the treatment vasculitis of using the present invention to prepare is festered, the Chinese medicine preparation of gangrenous usefulness is smeared the affected part, and less than recovery from illness after the course for the treatment of (20 days), red and swollen, pain disappears entirely.
Case 5
Liu Xiaoli, the man, 32 years old, the peasant, the difficulty of walking, both legs and foot's blackout are festered, and once remove various big hospital in Beijing 301 Hospital and the Shandong Province, and obstinate is venous thrombosis through numerous hospital diagnosis, worsens to be that gangrene, consensus want his amputation of performing the operation.Come company through the treatment of a month course for the treatment of in JIUYUE, 2012, use the treatment vasculitis of the present invention's preparation to fester, the Chinese medicine preparation of gangrenous usefulness smears the affected part, fully recovered more than three times every day, also can normally walk.
Claims (6)
- One kind treat vasculitis fester, the gangrene Chinese medicine for outer use, it is characterized in that being prepared from by the raw material that comprises following weight portion: 15～20 parts of Cortex Phellodendris, 20～30 parts of Cortex Pseudolariciss, 20～30 parts of Fructus Cnidiis, 35～40 parts of Galla Chinensiss, 5～10 parts of Myrrhas, 5～10 parts of Olibanums, 15～20 parts of Radix Ilicis Pubescentiss, 25～30 parts of Radix Notoginseng, 25～30 parts of Resina Draconis.
- Treatment vasculitis as claimed in claim 1 fester, the gangrene Chinese medicine for outer use, it is characterized in that being prepared from by the raw material that comprises following weight portion: 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis.
- 3. treat that vasculitis is festered, the preparation method of Chinese medicine for outer use of gangrene for one kind, it is characterized in that may further comprise the steps:(1) by weight, after the crude drug that will comprise 15～20 parts of Cortex Phellodendris, 20～30 parts of Cortex Pseudolariciss, 20～30 parts of Fructus Cnidiis, 35～40 parts of Galla Chinensiss, 5～10 parts of Myrrhas, 5～10 parts of Olibanums, 15～20 parts of Radix Ilicis Pubescentiss, 25～30 parts of Radix Notoginseng, 25～30 parts of Resina Draconis is pulverized, is mixed, the water heating and refluxing extraction 1.5～2.5 hours that adds 7～9 times of weight of described crude drug is filtered and is obtained respectively medicinal liquid and medicinal residues;(2) in the medicinal residues that step (1) obtains, add the water of 5～7 times of weight of described medicinal residues, heating and refluxing extraction 1.5～2.5 hours, the medicinal liquid that the medicinal liquid that filtration obtains and step (1) obtain merges, and then being concentrated into density is 1.05～1.1g/cm 3(3) in above-mentioned concentrated solution, add ethanol, place and draw supernatant more than 24 hours, then after the separation of ethanol in the supernatant being reclaimed, obtain Chinese medicine stock solution, it is 50～60wt% that described Chinese medicine stock solution adding distil water is transferred to middle concentration, then stirs, fill behind the fine straining, sealing obtains medical treatment, and vasculitis is festered, the Chinese medicine preparation of gangrenous usefulness.
- Treatment vasculitis as claimed in claim 3 fester, the preparation method of Chinese medicine for outer use of gangrene, it is characterized in that: described crude drug comprises 18 parts of Cortex Phellodendris, 25 parts of Cortex Pseudolariciss, 25 parts of Fructus Cnidiis, 38 parts of Galla Chinensiss, 8 parts of Myrrhas, 8 parts of Olibanums, 18 parts of Radix Ilicis Pubescentiss, 28 parts of Radix Notoginseng, 28 parts of Resina Draconis.
- Treatment vasculitis as claimed in claim 3 fester, the preparation method of Chinese medicine for outer use of gangrene, it is characterized in that: in the step (3), adding ethanol and regulate ethanol content in concentrated solution is 70～75wt%.
- Treatment vasculitis as claimed in claim 3 fester, the preparation method of Chinese medicine for outer use of gangrene, it is characterized in that: in the step (3), it is 50～60wt% that Chinese medicine stock solution adding distil water is transferred to middle concentration, then circulation stirring is 0.5～1 hour, and fill behind the fine straining, sealing obtain medical treatment that vasculitis is festered, the Chinese medicine preparation of gangrenous usefulness.
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| CN201210447876.1A CN102895450B (en) | 2012-11-09 | 2012-11-09 | External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene |
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| CN201210447876.1A CN102895450B (en) | 2012-11-09 | 2012-11-09 | External Chinese herbal preparation for treating angiitis fester and gangrene and method for preparing external Chinese herbal preparation for treating angiitis fester and gangrene |
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| CN102895450B CN102895450B (en) | 2014-06-25 |
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| CN110151872A (en) * | 2019-05-13 | 2019-08-23 | 广州市德升源生物科技有限公司 | It is a kind of for treating the Chinese medicine external side and its preparation method and application of vasculitis |
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