CN1297272C - 马来酸氯苯那敏的新用途 - Google Patents
马来酸氯苯那敏的新用途 Download PDFInfo
- Publication number
- CN1297272C CN1297272C CNB2005100378904A CN200510037890A CN1297272C CN 1297272 C CN1297272 C CN 1297272C CN B2005100378904 A CNB2005100378904 A CN B2005100378904A CN 200510037890 A CN200510037890 A CN 200510037890A CN 1297272 C CN1297272 C CN 1297272C
- Authority
- CN
- China
- Prior art keywords
- maleate
- present
- hepatitis
- chlorphenamine
- chlorpheniramine maleate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 title 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims abstract description 22
- 239000003814 drug Substances 0.000 claims abstract description 12
- 208000006454 hepatitis Diseases 0.000 claims abstract description 10
- 231100000283 hepatitis Toxicity 0.000 claims abstract description 10
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims abstract description 8
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims abstract description 8
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 claims abstract description 4
- 108010082126 Alanine transaminase Proteins 0.000 claims abstract description 4
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000007924 injection Substances 0.000 abstract description 4
- 238000002347 injection Methods 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 229940046978 chlorpheniramine maleate Drugs 0.000 abstract 3
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 11
- 229960003291 chlorphenamine Drugs 0.000 description 7
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 108090000340 Transaminases Proteins 0.000 description 4
- 102000003929 Transaminases Human genes 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 229960001340 histamine Drugs 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010067125 Liver injury Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 102000003834 Histamine H1 Receptors Human genes 0.000 description 1
- 108090000110 Histamine H1 Receptors Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 230000003153 cholinolytic effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
组别 | 剂量(mg/kg) | 动物数(只) | 血清转氨酶活力单位(u/100ml) | |
ALT | AST | |||
正常对照模型对照扑尔敏 | -10ml/kg 0.1%CCl43+CCl49+CCl427+CCl4 | 1010101010 | 85.21±26.45182.87±67.50146.60±57.21109.37±40.0951.35±20.52 | 101.1±74.2179.7±42.3187.5±41.2155.8±23.4144.1±16.7 |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100378904A CN1297272C (zh) | 2005-02-25 | 2005-02-25 | 马来酸氯苯那敏的新用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100378904A CN1297272C (zh) | 2005-02-25 | 2005-02-25 | 马来酸氯苯那敏的新用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1682722A CN1682722A (zh) | 2005-10-19 |
CN1297272C true CN1297272C (zh) | 2007-01-31 |
Family
ID=35262342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100378904A Active CN1297272C (zh) | 2005-02-25 | 2005-02-25 | 马来酸氯苯那敏的新用途 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1297272C (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111084808A (zh) * | 2019-12-29 | 2020-05-01 | 广东罗浮山国药股份有限公司 | 咳特灵制剂在治疗乙型肝炎中的应用 |
CN111450143B (zh) * | 2020-04-24 | 2022-03-15 | 广州白云山医药集团股份有限公司白云山制药总厂 | 小叶榕叶提取物在制备预防和/或治疗肝脏病变的药物中的用途 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1488351A (zh) * | 2003-08-15 | 2004-04-14 | 罗笑宇 | 一种治疗银屑病的酊剂 |
-
2005
- 2005-02-25 CN CNB2005100378904A patent/CN1297272C/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1488351A (zh) * | 2003-08-15 | 2004-04-14 | 罗笑宇 | 一种治疗银屑病的酊剂 |
Also Published As
Publication number | Publication date |
---|---|
CN1682722A (zh) | 2005-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: HENAN JIUSHI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: WANG XIAOSHAN Effective date: 20080411 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20080411 Address after: Huixian City, Henan Province Zhou Bu village southeast nine potential pharmaceutical Co. Ltd. Patentee after: Henan Jiushi Pharmaceutical Co., Ltd. Address before: Mei Shan Road, Anhui University of Traditional Chinese Medicine, Anhui, Hefei College of pharmacy Patentee before: Wang Xiaoshan |
|
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: Huixian City, Henan province 453600 week package southeast nine pharmaceutical company limited potential Patentee after: Henan Jiushi Pharmaceutical Co., Ltd. Address before: Huixian City, Henan province 453600 week package southeast nine pharmaceutical company limited potential Patentee before: Henan Jiushi Pharmaceutical Co., Ltd. |
|
PP01 | Preservation of patent right |
Effective date of registration: 20190308 Granted publication date: 20070131 |
|
PP01 | Preservation of patent right | ||
PD01 | Discharge of preservation of patent | ||
PD01 | Discharge of preservation of patent |
Date of cancellation: 20220308 Granted publication date: 20070131 |
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PP01 | Preservation of patent right |
Effective date of registration: 20220308 Granted publication date: 20070131 |
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PP01 | Preservation of patent right |