CN1292687A - 毫微颗粒、毫微颗粒的制备方法及其应用 - Google Patents

毫微颗粒、毫微颗粒的制备方法及其应用 Download PDF

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Publication number
CN1292687A
CN1292687A CN 99803733 CN99803733A CN1292687A CN 1292687 A CN1292687 A CN 1292687A CN 99803733 CN99803733 CN 99803733 CN 99803733 A CN99803733 A CN 99803733A CN 1292687 A CN1292687 A CN 1292687A
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CN
China
Prior art keywords
nanoparticles
oxygen base
phosphonium
urea
granule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 99803733
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English (en)
Chinese (zh)
Inventor
J·马尼罗
J·费尔彼
P·博德克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Research and Technologies GmbH and Co KG
Original Assignee
Hoechst Research and Technology Deutschland GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Research and Technology Deutschland GmbH and Co KG filed Critical Hoechst Research and Technology Deutschland GmbH and Co KG
Publication of CN1292687A publication Critical patent/CN1292687A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN 99803733 1998-03-13 1999-03-06 毫微颗粒、毫微颗粒的制备方法及其应用 Pending CN1292687A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19810965.2 1998-03-13
DE1998110965 DE19810965A1 (de) 1998-03-13 1998-03-13 Nanopartikel, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
CN1292687A true CN1292687A (zh) 2001-04-25

Family

ID=7860805

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 99803733 Pending CN1292687A (zh) 1998-03-13 1999-03-06 毫微颗粒、毫微颗粒的制备方法及其应用

Country Status (6)

Country Link
EP (1) EP1061904A1 (de)
JP (1) JP2002506814A (de)
CN (1) CN1292687A (de)
AU (1) AU3031899A (de)
DE (1) DE19810965A1 (de)
WO (1) WO1999047130A1 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100339712C (zh) * 2002-09-13 2007-09-26 日立化成工业株式会社 固定化载体和固相
CN101396351B (zh) * 2007-09-28 2011-04-27 上海交通大学医学院附属瑞金医院 可响应磷酸酶浓度的载药聚电解质胶囊及其制备方法
CN102813937A (zh) * 2012-06-12 2012-12-12 天津大学 含有疏水性药物的聚电解质复合物及其制备方法和应用

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19952073A1 (de) * 1999-10-29 2001-07-12 Cognis Deutschland Gmbh Verfahren zur Herstellung von nanopartikulären Chitosanen oder Chitosan-Derivaten
CA2427938C (en) 1999-11-15 2010-02-16 Bio Syntech Canada Inc. Novel temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution, composition and preparation thereof
DE10118852A1 (de) * 2001-04-17 2002-10-31 Fricker Gert Bdellosomen
DE10127526A1 (de) * 2001-05-31 2002-12-12 Novosom Ag Verfahren zur Herstellung und Auflösung von Nano- und Mikrokapseln
DE10132669B4 (de) * 2001-07-05 2008-08-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pharmakologische Zubereitung aus einem nanopartikulären mesomorphen Polyelektrolyt-Lipid-Komplex und mindestens einem Wirkstoff
DE60334224D1 (de) * 2002-07-16 2010-10-28 Biosyntech Canada Inc Zusammensetzung für die herstellung zellkompatibler, injizierbarer, selbstgelierender chitosan lösungen zum einkapseln und verabreichen von lebenden zellen oderbiologisch aktiven faktoren
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
EP2125030A2 (de) * 2007-01-29 2009-12-02 Medipol S.A. Kolloidale partikel auf chitosan-basis zur rna-abgabe
ITRM20070327A1 (it) * 2007-06-11 2008-12-12 Univ Palermo Vettori colloidali a struttura poliamminoacidica per il rilascio orale di peptidi e proteine e relativo metodo di produzione.
WO2009035438A1 (en) * 2007-09-13 2009-03-19 Janos Borbely Polymeric nanoparticles by ion-ion interactions
WO2009079066A2 (en) * 2007-09-26 2009-06-25 Aparna Biosciences Therapeutic and vaccine polyelectrolyte nanoparticle compositions
WO2009094060A1 (en) 2008-01-24 2009-07-30 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
EP2266546A1 (de) 2009-06-08 2010-12-29 Advancell Advanced in Vitro Cell Technologies,S.A. Verfahren zur Herstellung kolloidaler Systeme zur Abgabe von Wirkstoffen
WO2011149907A1 (en) * 2010-05-24 2011-12-01 University Of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
CA2812599A1 (en) 2010-11-12 2012-05-18 University Of Utah Research Foundation Simple adhesive coacervates and methods of making and using thereof
EP2953992B1 (de) 2013-02-06 2021-11-24 3M Innovative Properties Company Polymere sowie herstellung und verwendung davon
EP3169374B1 (de) 2014-07-14 2022-01-05 University of Utah Research Foundation In-situ-verfestigende komplexe koazervate sowie verfahren zur herstellung und verwendung davon
US20190015351A1 (en) * 2017-07-14 2019-01-17 Drexel University Multifunctional Nanoparticles For Prevention And Treatment Of Atherosclerosis
AU2019212513B2 (en) 2018-01-26 2024-10-31 Fluidx Medical Technology, Llc Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3937283A1 (de) * 1989-11-09 1991-05-16 Hoechst Ag Polyelektrolytkomplexe zur behandlung und prophylaxe von viruserkrankungen, neue polyelektrolytkomplexe sowie verfahren zu deren herstellung
DK0454044T3 (da) * 1990-04-25 1996-04-22 Hoechst Ag Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof
JP3296817B2 (ja) * 1991-04-02 2002-07-02 バイオテック・オーストラリア・ピーティーワイ・リミテッド 微粒子に適した経口配布系
DE4407898A1 (de) * 1994-03-09 1995-09-14 Hoechst Ag Nanopartikel, enthaltend einen Wirkstoff und ein Polyketalweinsäureamid, Verfahren zu ihrer Herstellung und Verwendung derselben
AU9799198A (en) * 1997-10-09 1999-05-03 Vanderbilt University Micro-particulate and nano-particulate polymeric delivery system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100339712C (zh) * 2002-09-13 2007-09-26 日立化成工业株式会社 固定化载体和固相
CN101396351B (zh) * 2007-09-28 2011-04-27 上海交通大学医学院附属瑞金医院 可响应磷酸酶浓度的载药聚电解质胶囊及其制备方法
CN102813937A (zh) * 2012-06-12 2012-12-12 天津大学 含有疏水性药物的聚电解质复合物及其制备方法和应用

Also Published As

Publication number Publication date
WO1999047130A1 (de) 1999-09-23
DE19810965A1 (de) 1999-09-16
JP2002506814A (ja) 2002-03-05
EP1061904A1 (de) 2000-12-27
AU3031899A (en) 1999-10-11

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