CN1289333A - 用作血清素－1a受体激动剂的噁唑衍生物 - Google Patents

用作血清素－1a受体激动剂的噁唑衍生物 Download PDF

Info

Publication number
CN1289333A
CN1289333A CN99802651A CN99802651A CN1289333A CN 1289333 A CN1289333 A CN 1289333A CN 99802651 A CN99802651 A CN 99802651A CN 99802651 A CN99802651 A CN 99802651A CN 1289333 A CN1289333 A CN 1289333A
Authority
CN
China
Prior art keywords
carbon atom
compound
contain
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99802651A
Other languages
English (en)
Chinese (zh)
Inventor
M·G·克利
L·P·格林布拉特
F·C·内尔森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of CN1289333A publication Critical patent/CN1289333A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN99802651A 1998-02-03 1999-02-02 用作血清素－1a受体激动剂的噁唑衍生物 Pending CN1289333A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1751798A 1998-02-03 1998-02-03
US09/017517 1998-02-03

Publications (1)

Publication Number Publication Date
CN1289333A true CN1289333A (zh) 2001-03-28

Family

ID=21783033

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99802651A Pending CN1289333A (zh) 1998-02-03 1999-02-02 用作血清素－1a受体激动剂的噁唑衍生物

Country Status (6)

Country Link
EP (1) EP1053235A1 (ja)
JP (1) JP2002501920A (ja)
CN (1) CN1289333A (ja)
AU (1) AU2575399A (ja)
CA (1) CA2317515A1 (ja)
WO (1) WO1999038864A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105829297A (zh) * 2013-12-20 2016-08-03 埃斯蒂文博士实验室股份有限公司 具有抗疼痛的多重模式活性的哌啶化合物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242448B1 (en) * 1998-12-17 2001-06-05 American Home Products Corporation Trisubstituted-oxazole derivatives as serotonin ligands
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
EP1855679B1 (en) * 2005-01-19 2016-06-29 Merck Sharp & Dohme Corp. Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
GB0516313D0 (en) * 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008272A (en) * 1988-08-15 1991-04-16 Glaxo Group Limited Lactam derivatives
US5162322A (en) * 1991-03-06 1992-11-10 A. H. Robbins Company, Incorporated Method of treating anxiety with 5-[(4-aryl or heteroaryl-1-piperazinyl]alkyl)-2-oxazolidinones

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105829297A (zh) * 2013-12-20 2016-08-03 埃斯蒂文博士实验室股份有限公司 具有抗疼痛的多重模式活性的哌啶化合物
CN105829297B (zh) * 2013-12-20 2019-08-09 埃斯蒂文制药股份有限公司 具有抗疼痛的多重模式活性的哌啶化合物

Also Published As

Publication number Publication date
WO1999038864A1 (en) 1999-08-05
JP2002501920A (ja) 2002-01-22
EP1053235A1 (en) 2000-11-22
AU2575399A (en) 1999-08-16
CA2317515A1 (en) 1999-08-05

Similar Documents

Publication Publication Date Title
JP2000063276A (ja) ５ＨＴ１Ａリガンドとしてのピロロ［１，２―ａ］ピラジン誘導体
CN1149873A (zh) 作为5-ht1a拮抗剂的哌嗪衍生物
EP0356128A2 (en) 3-(Aminopropyl)methyl phosphinic acid as a therapeutic agent
CN87101689A (zh) 芳族2-氨烷基-1，2-苯并异噻唑-3(2h)酮-1，1-二氧化物衍生物
CN1379761A (zh) 稠合二氢吲哚衍生物及其作为5ht特别是5ht2c受体配体的用途
CN1289333A (zh) 用作血清素－1a受体激动剂的噁唑衍生物
CN1082044A (zh) 吲哚衍生物
CN1160360C (zh) 用于增强突触应答的氧氮杂萘化合物
US20090192194A1 (en) Cyclic Amine Derivatives, Processes For Their Preparation, And Pharmaceutical Compositions Containing Them
CN1013864B (zh) 抗精神病的γ-咔啉的制备方法
CN1167698C (zh) 用作神经激肽受体拮抗剂的n-三唑基甲基哌嗪衍生物
CN1450995A (zh) 用于治疗青光眼的5－羟基吲唑衍生物
CN1066145C (zh) N－取代的3－氮杂双环[3,2,0]庚烷衍生物及其制备方法和应用
JPH08502283A (ja) ５−ｈｔ▲下４▼レセプターアンタゴニスト用の縮合環系ｎ−アルキルピペリジニル−４−メチルカルボン酸エステル／アミド
CN1293669A (zh) 苄基哌嗪基－和苄基哌啶基－乙酮衍生物、其制备方法及其用作多巴胺d 受体拮抗剂的用途
CN1043574C (zh) 具有中枢神经系统活性的杂环胺
CN1307574A (zh) 作为5－羟色胺能药物的吲哚基衍生物
RU2204558C2 (ru) Производное бензоксазола, лекарственное средство на его основе и способ лечения состояния синдрома раздраженного кишечника или функционального расстройства пищеварительного тракта
CN1976928A (zh) 作为5－羟基色胺－6配体的吲哚基烷基胺代谢物
CN1335835A (zh) 具有5ht1a受体活性的芳基哌啶和芳基－1,2,5,6－四氢吡啶脲衍生物
EP1241169B1 (fr) Dérivés d'isoindoloindolone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
CN1168728C (zh) 吡咯并异喹啉和四氢吡咯并异喹衍生物及其作为5-ht7受体介体的应用
CN1307576A (zh) 5－羟色胺能药物
KR102103768B1 (ko) 5-ht2c 항진제로서의 활성을 가지는 광학 활성의 2-아미노-4-알콕시 피리미딘 유도체
CN1146992A (zh) 中间体(r)-3-氨基-5-甲氧基苯并二氢吡喃的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent for invention or patent application
CB02 Change of applicant information

Applicant after: Wyeth Corp.

Applicant before: American Home Products Corp.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: AMERICAN HOME PRODUCTS CORP. TO: WYETH CORP.

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication