CN1284969C - 带自校正的微流体控制器和检测器系统 - Google Patents
带自校正的微流体控制器和检测器系统 Download PDFInfo
- Publication number
- CN1284969C CN1284969C CN99812168.1A CN99812168A CN1284969C CN 1284969 C CN1284969 C CN 1284969C CN 99812168 A CN99812168 A CN 99812168A CN 1284969 C CN1284969 C CN 1284969C
- Authority
- CN
- China
- Prior art keywords
- detector system
- microfluidic controller
- voltage
- electrode
- light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/148—Specific details about calibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10426098P | 1998-10-14 | 1998-10-14 | |
US60/104,260 | 1998-10-14 | ||
US09/374,878 | 1999-08-13 | ||
US09/374,878 US6498497B1 (en) | 1998-10-14 | 1999-08-13 | Microfluidic controller and detector system with self-calibration |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1323393A CN1323393A (zh) | 2001-11-21 |
CN1284969C true CN1284969C (zh) | 2006-11-15 |
Family
ID=26801344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN99812168.1A Expired - Fee Related CN1284969C (zh) | 1998-10-14 | 1999-10-12 | 带自校正的微流体控制器和检测器系统 |
Country Status (7)
Country | Link |
---|---|
US (2) | US6498497B1 (fr) |
EP (1) | EP1121587B1 (fr) |
JP (1) | JP2002527746A (fr) |
CN (1) | CN1284969C (fr) |
AU (1) | AU761071C (fr) |
CA (1) | CA2344827A1 (fr) |
WO (1) | WO2000022424A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102507523A (zh) * | 2011-11-09 | 2012-06-20 | 大连理工大学 | 基于oled和opd的层叠垂直式集成毛细管电泳芯片 |
Families Citing this family (83)
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US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
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US6635487B1 (en) * | 2000-05-17 | 2003-10-21 | Caliper Technologies Corp. | Fluorescence standard for use in microfluidic instruments |
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US20090118139A1 (en) | 2000-11-07 | 2009-05-07 | Caliper Life Sciences, Inc. | Microfluidic method and system for enzyme inhibition activity screening |
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US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US20050032204A1 (en) * | 2001-04-10 | 2005-02-10 | Bioprocessors Corp. | Microreactor architecture and methods |
US20040058407A1 (en) * | 2001-04-10 | 2004-03-25 | Miller Scott E. | Reactor systems having a light-interacting component |
US20040132166A1 (en) * | 2001-04-10 | 2004-07-08 | Bioprocessors Corp. | Determination and/or control of reactor environmental conditions |
AU2002345465B2 (en) * | 2001-06-29 | 2007-04-26 | Ge Healthcare Bio-Sciences Ab | Flow cell method |
US20050026134A1 (en) * | 2002-04-10 | 2005-02-03 | Bioprocessors Corp. | Systems and methods for control of pH and other reactor environment conditions |
US7452507B2 (en) * | 2002-08-02 | 2008-11-18 | Sandia Corporation | Portable apparatus for separating sample and detecting target analytes |
WO2004094986A2 (fr) | 2003-04-16 | 2004-11-04 | Handylab, Inc. | Systeme et procede de detection electrochimique de composes biologiques |
EP2402089A1 (fr) | 2003-07-31 | 2012-01-04 | Handylab, Inc. | Traitement d'échantillons contenant des particules |
US20050136500A1 (en) * | 2003-12-19 | 2005-06-23 | Kimberly-Clark Worldwide; Inc. | Flow-through assay devices |
US7943089B2 (en) * | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
WO2005108620A2 (fr) | 2004-05-03 | 2005-11-17 | Handylab, Inc. | Traitement d'échantillons contenant des polynucléotides |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
WO2005114223A2 (fr) * | 2004-05-21 | 2005-12-01 | Caliper Life Sciences, Inc. | Système automatique de manipulation de dispositifs microfluidiques |
US20070036690A1 (en) * | 2004-06-07 | 2007-02-15 | Bioprocessors Corp. | Inlet channel volume in a reactor |
US20050277187A1 (en) * | 2004-06-07 | 2005-12-15 | Bioprocessors Corp. | Creation of shear in a reactor |
EP2701194B1 (fr) | 2004-06-07 | 2018-08-29 | Fluidigm Corporation | Procédé et appareil pour l'imagerie d'un dispositif microfluidique sous contrôle de température. |
EP1765487A1 (fr) * | 2004-06-07 | 2007-03-28 | Bioprocessors Corporation | Melange de reacteur |
US8097225B2 (en) * | 2004-07-28 | 2012-01-17 | Honeywell International Inc. | Microfluidic cartridge with reservoirs for increased shelf life of installed reagents |
CN1786710B (zh) * | 2004-12-06 | 2011-12-14 | 财团法人工业技术研究院 | 检体分析微流体芯片及其方法 |
US7682817B2 (en) * | 2004-12-23 | 2010-03-23 | Kimberly-Clark Worldwide, Inc. | Microfluidic assay devices |
AU2006240184A1 (en) * | 2005-04-12 | 2006-11-02 | Caliper Life Sciences, Inc. | Compact optical detection system for a microfluidic devices |
US8206974B2 (en) | 2005-05-19 | 2012-06-26 | Netbio, Inc. | Ruggedized apparatus for analysis of nucleic acid and proteins |
DK2001990T3 (en) | 2006-03-24 | 2016-10-03 | Handylab Inc | Integrated microfluidic sample processing system and method for its use |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
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CA2580589C (fr) * | 2006-12-19 | 2016-08-09 | Fio Corporation | Systeme de detection microfluidique |
WO2008119184A1 (fr) | 2007-04-02 | 2008-10-09 | Fio Corporation | Système et procédé de déconvolution de signaux spectraux de fluorescence multiplexés produits par une technique de codage optique par points quantiques |
JP2010530912A (ja) | 2007-06-22 | 2010-09-16 | フィオ コーポレイション | 量子ドットをドープしたポリマーマイクロビーズの製造システム及び方法 |
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CA3082652A1 (fr) | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Thermocycleur microfluidique en temps reel a balayage et procedes synchronises de thermocyclage et de detection optique a balayage |
EP3447148A1 (fr) | 2011-05-12 | 2019-02-27 | NetBio, Inc. | Procédés et compositions destinés à l'amplification multiplex rapide de loci de séquences courtes répétées en tandem |
WO2013007028A1 (fr) * | 2011-07-14 | 2013-01-17 | 深圳西德赛科技有限公司 | Procédé et système pour l'étalonnage automatique d'un système de détection fondé sur une puce microfluidique |
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CN103959070B (zh) | 2011-09-30 | 2017-05-10 | 贝克顿·迪金森公司 | 组合试剂条 |
CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
CN107881219B (zh) | 2012-02-03 | 2021-09-10 | 贝克顿·迪金森公司 | 用于分子诊断测试分配和测试之间兼容性确定的外部文件 |
PL2864781T3 (pl) * | 2012-06-22 | 2018-05-30 | Scandinavian Micro Biodevices Aps | Sposób i układ do jakościowego lub ilościowego oznaczania składnika docelowego |
CN102989538B (zh) * | 2012-12-17 | 2016-08-10 | 江西恒盛晶微技术有限公司 | 微流控芯片的夹持装置 |
KR102200600B1 (ko) | 2014-02-27 | 2021-01-11 | 엘지전자 주식회사 | 부유미생물 측정장치 및 그 측정방법 |
CN107238573A (zh) * | 2016-03-29 | 2017-10-10 | 光宝电子(广州)有限公司 | 流体检测装置 |
USD800335S1 (en) * | 2016-07-13 | 2017-10-17 | Precision Nanosystems Inc. | Microfluidic chip |
KR102551430B1 (ko) * | 2016-12-01 | 2023-07-05 | 버클리 라잇츠, 인크. | 미세-객체들을 이미징하기 위한 장치들, 시스템들 및 방법들 |
CN108444917B (zh) * | 2018-06-05 | 2024-07-26 | 深圳迎凯生物科技有限公司 | 自校准的弱光检测装置 |
WO2020142902A1 (fr) | 2019-01-08 | 2020-07-16 | 京东方科技集团股份有限公司 | Panneaux et dispositif de détection de fluides |
CN109632660B (zh) * | 2019-01-17 | 2022-04-05 | 京东方科技集团股份有限公司 | 流体检测面板 |
MX2021012697A (es) * | 2019-04-24 | 2021-11-12 | Jfe Steel Corp | Dispositivo de deteccion de defectos de flujo de fugas. |
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-
1999
- 1999-08-13 US US09/374,878 patent/US6498497B1/en not_active Expired - Lifetime
- 1999-10-12 EP EP99953143.7A patent/EP1121587B1/fr not_active Expired - Lifetime
- 1999-10-12 CN CN99812168.1A patent/CN1284969C/zh not_active Expired - Fee Related
- 1999-10-12 JP JP2000576271A patent/JP2002527746A/ja active Pending
- 1999-10-12 CA CA002344827A patent/CA2344827A1/fr not_active Abandoned
- 1999-10-12 AU AU65148/99A patent/AU761071C/en not_active Ceased
- 1999-10-12 WO PCT/US1999/023756 patent/WO2000022424A1/fr active IP Right Grant
-
2002
- 2002-08-09 US US10/215,885 patent/US6986837B2/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102507523A (zh) * | 2011-11-09 | 2012-06-20 | 大连理工大学 | 基于oled和opd的层叠垂直式集成毛细管电泳芯片 |
Also Published As
Publication number | Publication date |
---|---|
AU761071C (en) | 2004-02-12 |
CA2344827A1 (fr) | 2000-04-20 |
AU6514899A (en) | 2000-05-01 |
US20030011382A1 (en) | 2003-01-16 |
EP1121587A1 (fr) | 2001-08-08 |
US6986837B2 (en) | 2006-01-17 |
WO2000022424A1 (fr) | 2000-04-20 |
EP1121587B1 (fr) | 2018-12-26 |
JP2002527746A (ja) | 2002-08-27 |
AU761071B2 (en) | 2003-05-29 |
US6498497B1 (en) | 2002-12-24 |
EP1121587A4 (fr) | 2005-09-07 |
CN1323393A (zh) | 2001-11-21 |
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