CN1284570C - 一种治疗高血脂症的中药制剂及其制备方法 - Google Patents
一种治疗高血脂症的中药制剂及其制备方法 Download PDFInfo
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- CN1284570C CN1284570C CN 200410070638 CN200410070638A CN1284570C CN 1284570 C CN1284570 C CN 1284570C CN 200410070638 CN200410070638 CN 200410070638 CN 200410070638 A CN200410070638 A CN 200410070638A CN 1284570 C CN1284570 C CN 1284570C
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
组别 | n | T-CHO mmol/L) | TG(mmol/L) | ||
给药前 | 给药后 | 给药前 | 给药后 | ||
A组(正常对照)B组(高脂模型)C组(血脂康)D组(小剂量)E组(中剂量)F组(大剂量) | 8710977 | 2.075±0.5342.194±0.4272.279±0.3712.404±0.4592.264±0.5752.296±0.704 | 2.094±0.43813.926±2.181**8.894±1.984△△6.580±1.045△△△△8.447±1.788△△6.831±2.136△△ | 0.804±0.1810.826±0.1990.825±0.2340.941±0.4160.889±0.3230.823±0.181 | 1.033±0.3542.090±0.397**1.254±0.490△△1.176±0.343△△0.863±0.114△△△1.206±0.358△△ |
组别 | n | HDL(MML/L) | HDL2(mml/L) | HDL3(mmol/L) | mmol/L) | ||||
给药前 | 给药后 | 给药前 | 给药后 | 给药前 | 给药后 | 给药前 | 给药后 | ||
A组(对照组)B组(模型组)C组(血脂康)D组(小剂量)E组(中剂量)F组(大剂量) | 8710977 | 0.863±0.2570.893±0.0850.771±0.1070.768±0.0810.830±0.1260.771±0.161 | 0.765±0.481△△0.964±0.065**1.315±0.182△△1.263±0.124△△▲▲1.221±0.120△△1.279±0.084△△ | 0.528±0.0730.554±0.0690.520±0.0830.512±0.0970.579±0.0580.537±0.066 | 0.522±0.097△△0.410±0.065**0.672±0.140△△0.836±0.135△△▲0.809±0.125△△0.851±0.138△△▲ | 0.249±0.0670.253±0.0800.203±0.0630.201±0.0690.151±0.0640.212±0.070 | 0.242±0.0470.554±0.1820.630±0.2630.422±0.123▲0.409±0.115▲0.434±0.106 | 0.906±0.2620.911±0.2110.902±0.3671.147±0.2771.066±0.4161.111±0.664 | 1.001±0.455△△12000±2334**7.592±1.652△△5.322±1.764△△▲7.234±1.706△△5.539±1.704△ |
组别 | n | apoA-1(g/L) | apoB(b/L) | Lp(a)(mg/L) | |||
给药前 | 给药后 | 给药前 | 给药后 | 给药前 | 给药后 | ||
A(对照组)B(模型组)C(血脂康)D(小剂量)E(中剂量)F(大剂量) | 8710977 | 0.195±0.0330.190±0.0470.200±0.0370.194±0.0340.197±0.0460.176±0.024 | 0.100±0.001△△0.063±0.014**0.143±0.039△△0.161±0.045△△0.167±0.039△△0.180±0.026△△▲ | 0.111±0.0350.144±0.0180.138±0.0350.116±0.0520.117±0.0610.156±0.040 | 0.133±0.027△△1.856±0.500**1.250±0.229△1.202±0.171△0.946±0.233△△▲1.317±0.154△ | 220.1±21.1216.0±20.2220.2±21.2224.2±25.8201.3±12.4213.5±23.4 | 221.9±9.1△△1037.1±219.1**478.9±110.1△△249.8±44.6△△▲▲369.6±56.5△△▲348.5±53.8△△▲▲ |
组别 | n | 全血粘度 | 血浆粘度 | ||
低切 | 中切 | 高切 | |||
A组(对照组)B组(模型组)C组(血脂康)D组(小剂量)E组(中剂量)F组(大剂量) | 8710977 | 10.413±0.94713.870±2.396**11.178±0.619△△12.101±1.06911.206±1.934△10.273±2.229△ | 7.332±0.6289.343±1.221**7.650±0.429△△8.126±0.564△7.809±1.111△6.952±0.522▲△ | 3.420±0.2193.957±0.3563.571±0.199△3.553±0.145△3.556±0.271△3.514±0.337△ | 1.579±0.1262.022±0.1111.734±0.157△△1.869±0.1321.795±0.169△△1.595±0.148△△ |
组别 | n | SOD(亚硝酸盐单位/ml) |
A(正常对照)B(高脂模型)C(血脂康)D(小剂量)E(中剂量)F(大剂量) | 8710977 | 149.394±22.075114.559±7.623**168.388±23.581△△164.315±19.089△△139.783±14.999△△▲▲135.764±26.193▲ |
组别 | n | X±SD |
A(正常对照)B(高脂模型)C(血脂康组)D(小剂量)E(中剂量)F(大剂量) | 8710977 | 0±02.286±1.380**1.600±1.5060.778±0.972△0.714±0.756△1.667±1.367 |
组别 | 动物数(只) | 斑块形成动物只数 | |
- | + | ||
A(正常对照)B(高脂模型)C(血脂康)D(小剂量)E(中剂量)F(大剂量) | 8710977 | 8036※5※2 | 77325 |
组别 | n | 肝重/100g体重(X±SD) |
A(正常对照)B(高脂模型)C(血脂康组)D(小剂量)E(中剂量)F(大剂量) | 8710977 | 0.029±0.0080.043±0.007**0.039±0.009*0.036±0.0110.042±0.005**0.045±0.008** |
Claims (9)
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CN101474243A (zh) * | 2008-11-14 | 2009-07-08 | 杜志政 | 具有血管清道夫功能的植物提取物组合物及其制备方法 |
CN101491333B (zh) * | 2009-02-11 | 2012-02-22 | 陆小左 | 降血脂茶 |
CN102520113B (zh) * | 2011-12-16 | 2014-05-07 | 西藏奇正藏药股份有限公司 | 十五味乳鹏制剂的检测方法 |
CN103141901A (zh) * | 2013-03-07 | 2013-06-12 | 王玉兰 | 一种楂皮饮 |
CN104474382A (zh) * | 2014-11-20 | 2015-04-01 | 周艳 | 一种降血脂的中药及制备方法 |
CN110441462A (zh) * | 2019-07-30 | 2019-11-12 | 西安碑林药业股份有限公司 | 一种中药制剂和血明目片中大黄酚的检测方法 |
CN110927322B (zh) * | 2019-11-07 | 2022-05-17 | 石药集团中奇制药技术(石家庄)有限公司 | 一种藿香正气合剂的检测方法 |
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