CN1274357C - Chinese patent drug for treatnig liver fibration and cirrhosis, preparing method for its preparation - Google Patents

Abstract

The present invention relates to a Chinese patent medicine for treating hepatic fibrosis and hepatic cirrhosis and a preparing method thereof, which belongs to the technical field of Chinese patent medicines and preparing methods thereof. The present invention aims to solve a technical problem of providing a Chinese patent medicine which has outstanding therapeutic effect and can treat hepatic fibrosis and hepatic cirrhosis and a preparing method thereof. The Chinese patent medicine is characterized in that the Chinese patent medicine is composed of the raw material components of the percentages by weight: 6 to 20 of curcuma aromatica salisb, 6 to 20 of agaric, 6 to 20 of red peony root, 6 to 15 of green tangerine peel, 6 to 20 of costustoot, 6 to 20 of areca peel, 6 to 20 of oriental waterplantain rhizome, 6 to 15 of prepared officinal magnolia bark, 6 to 20 of chicken's gizzard-skin and 20 to 30 of turtle shell. Pharmacodynamics experiments indicate that the Chinese patent medicine of the present invention has significant preventive and therapeutic effect on both acute and chronic hepatic injury and hepatic fibrosis, and can also correct abnormal immune functions. Acute toxicity experiments and long-term toxicity experiments indicate that the Chinese patent medicine does not have toxicity and harm to the heart, the liver, the kidney, the brain and other essential organs, and the phenomena that the pathological changes of other organs are caused are not discovered.

Description

A kind of preparation method for the treatment of the Chinese patent medicine and the preparation thereof of hepatic fibrosis and liver cirrhosis

Technical field: the present invention relates to a kind of Chinese patent medicine and preparation method thereof, particularly a kind of preparation method for the treatment of the Chinese patent medicine and the preparation thereof of hepatic fibrosis and liver cirrhosis.

Background technology: hepatic fibrosis and liver cirrhosis are by chronic, the carrying out property due to the different causes of disease such as viral hepatitis, schistosomicide, alcoholism, drug intoxication, cholestasis, circulatory disturbance, liver are aging, diffusivity hepatic disease.The treatment of hepatic fibrosis and liver cirrhosis is a very stubborn problem of present medical circle, in, doctor trained in Western medicine is for hepatic fibrosis and the liver cirrhosis definite medicine of inefficacy still.

Summary of the invention: technical problem to be solved by this invention is: a kind of determined curative effect is provided, can treats the preparation method of the Chinese patent medicine and the preparation thereof of hepatic fibrosis and liver cirrhosis.Its technical scheme is: a kind of Chinese patent medicine for the treatment of hepatic fibrosis and liver cirrhosis is characterized in that its raw material components and percentage by weight thereof:

Radix Curcumae 6-20 Polyporus 6-20 Radix Paeoniae Rubra 6-20 Pericarpium Citri Reticulatae Viride 6-15

Radix Aucklandiae 6-20 Pericarpium Arecae 6-20 Rhizoma Alismatis 6-20 Cortex Magnoliae Officinalis 6-15

Endothelium Corneum Gigeriae Galli 6-20 Carapax Trionycis 20-30

The preparation method of its preparation is:

1) Endothelium Corneum Gigeriae Galli, Carapax Trionycis add 8-12 times of water gaging, decoct 4 times, and each 4 hours, filter, merging filtrate concentrates, and drying is ground into fine powder;

2) Polyporus adds 8-12 times of water gaging, decoct 3 times, and each 3 hours, filter, merging filtrate concentrates, and drying is ground into fine powder;

3) Radix Paeoniae Rubra, Radix Curcumae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, thickly pounce on, Pericarpium Arecae, Rhizoma Alismatis and Radix Curcumae seven flavor medicine add 10-12 times of water gaging and soaked 1 hour, heating decocts 3 times, each 1 hour, filter, merging filtrate is concentrated into the clear paste that relative density is 1.10-1.20, adding ethanol makes the alcohol amount of containing reach 50-70%, stir evenly, leave standstill 24h, filter, filtrate recycling ethanol is to there not being the alcohol flavor, concentrate, drying is ground into fine powder;

4) merge above-mentioned all extract powders, and add dextrin, mixing is granulated, drying, and granulate is made tablet or granule or pill or capsule dosage form.

In the raw material components of the present invention, Radix Curcumae in can promoting the circulation of blood gas and evacuate the pent-up of irritability, again can removing heat from blood is broken become silted up; Polyporus can open the sharp key of the natural fibre line of meat, and eliminating dampness and diuresis has stronger diuresis, for the full medicine commonly used of the swelling of harnessing the river, share with Radix Curcumae, and with depressed liver-energy dispersing and QI regulating, the silt of dispelling that dehumidifies is monarch altogether.The soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride, consumer product dredge stasis; Radix Aucklandiae relieving distension by promoting circulation of QI has the merit of strengthening the spleen to promote digestion concurrently; The silt of dispelling of Radix Paeoniae Rubra removing heat from blood, the kind congestion that looses, and change silt and do not hinder network helps monarch's Radix Curcumae depressed liver-energy dispersing and QI regulating altogether with Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, removes and completely changes silt, to control costa sternales abdominal distention or lump in the abdomen.The Cortex Magnoliae Officinalis circulation of qi promoting is loose full, and dampness is amusing; Pericarpium Arecae therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, inducing diuresis to remove edema; It is wet that Rhizoma Alismatis is oozed diuretic, eliminates edema, helps monarch's Polyporus diuretic to dehumidify altogether with Cortex Magnoliae Officinalis, Pericarpium Arecae, has water, limb to swell to control abdominal distention.This assists monarch drug strengthening depressed liver-energy dispersing and QI regulating jointly, and the dispel effect of silt of dehumidifying is ministerial drug.Carapax Trionycis hard masses softening and resolving and just not hindering is with the soft liver of Radix Paeoniae Rubra, Pericarpium Citri Reticulatae Viride that the helps minister silt that disappears; Endothelium Corneum Gigeriae Galli strengthening the spleen to promote digestion and strong spleen stomach reinforcing with the Radix Aucklandiae that helps minister, the thick invigorating the spleen and stomach of pouncing on, is assistant altogether with Carapax Trionycis.Full side gather altogether depressed liver-energy dispersing and QI regulating, remove the effect of humidifying silts and the retention of dampness due to stagnation of QI folder for the treatment of tympanites becomes silted up and demonstrate,proves.

Show through pharmacodynamics test: Chinese medicine of the present invention is to D-GaIN, CCl4 and BCG+LPS difference inducing mouse acute liver damage, rat liver fibrosis and mouse immune liver damage model, Chinese medicine 3,6,12 crude drug g/Kg of the present invention not only all have tangible preventive and therapeutic effect to acute and chronic hepatic injury and hepatic fibrosis, and can correct unusual immunologic function; Acute toxicity test, long term toxicity test show: divide in 24 hours and irritate stomach for 2 times and give mice 1.0mI Cmax (behind the drug solns, observed continuously 14 during 3.87g crude drug/mI) is of the present invention, mice is toxigenicity reaction and dead not; Give 24 weeks of Wister rat continuous irrigation stomach 9.7,19.4,38.8g/Kg (be equivalent to respectively clinical consumption 28,56,112 times),, also do not see the phenomenon that causes other organ lesion the infringement of substantial viscera avirulences such as its heart, liver, kidney, brain.The maximum tolerated dose of Chinese medicine of the present invention is 193g crude drug/Kg, is equivalent to 554 times of clinical application amount.

The specific embodiment:

Embodiment 1.Get Endothelium Corneum Gigeriae Galli 6Kg, Carapax Trionycis 30Kg, add its 8 times of water gagings, decoct 4 times, each 4 hours, filter, merging filtrate concentrates, and drying is ground into fine powder; Get Polyporus 6Kg, add its 8 times of water gagings, decoct 3 times, each 3 hours, filter, merging filtrate concentrates, and drying is ground into fine powder; Seven flavor medicines such as Radix Paeoniae Rubra, Radix Curcumae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, thick pouncing on (system), Pericarpium Arecae, Rhizoma Alismatis are respectively got 6Kg, and 10 times of water gagings that add its total amount soaked 1 hour, and heating decocts 3 times, each 1 hour, filter merging filtrate, be concentrated into the clear paste that relative density is 1.10-1.20, add ethanol and make and contain alcohol amount and reach 50-70%, stir evenly, leave standstill 24h, filter, filtrate recycling ethanol concentrates to there not being the alcohol flavor, drying is ground into fine powder; Merge above-mentioned all extract powders, and add dextrin, mixing is granulated, drying, and granulate incapsulates, and promptly gets capsule.Its content be yellowish-brown to the brown granule, feeble QI perfume (or spice), mildly bitter flavor.

Embodiment 2.Get Endothelium Corneum Gigeriae Galli 15Kg, Carapax Trionycis 25Kg, add its 10 times of water gagings, decoct 4 times, each 4 hours, filter, merging filtrate concentrates, and drying is ground into fine powder; Get Polyporus 15Kg, add its 10 times of water gagings, decoct 3 times, each 3 hours, filter, merging filtrate concentrates, and drying is ground into fine powder; Seven flavor medicines such as Radix Paeoniae Rubra, Radix Curcumae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, thick pouncing on (system), Pericarpium Arecae, Rhizoma Alismatis are respectively got 15Kg, and 11 times of water gagings that add its total amount soaked 1 hour, and heating decocts 3 times, each 1 hour, filter merging filtrate, be concentrated into the clear paste that relative density is 1.10-1.20, add ethanol and make and contain alcohol amount and reach 50-70%, stir evenly, leave standstill 24h, filter, filtrate recycling ethanol concentrates to there not being the alcohol flavor, drying is ground into fine powder; Merge above-mentioned all extract powders, and add dextrin, mixing is granulated, drying, and granulate promptly gets granule.It is yellowish-brown to the brown granule, feeble QI perfume (or spice), mildly bitter flavor.

Embodiment 3.Get Endothelium Corneum Gigeriae Galli 20Kg, Carapax Trionycis 20Kg, add its 12 times of water gagings, decoct 4 times, each 4 hours, filter, merging filtrate concentrates, and drying is ground into fine powder; Get Polyporus 20Kg, add its 10 times of water gagings, decoct 3 times, each 3 hours, filter, merging filtrate concentrates, and drying is ground into fine powder; Seven flavor medicines such as Radix Paeoniae Rubra, Radix Curcumae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, thick pouncing on (system), Pericarpium Arecae, Rhizoma Alismatis are respectively got 20Kg, and 12 times of water gagings that add its total amount soaked 1 hour, and heating decocts 3 times, each 1 hour, filter merging filtrate, be concentrated into the clear paste that relative density is 1.10-1.20, add ethanol and make and contain alcohol amount and reach 50-70%, stir evenly, leave standstill 24h, filter, filtrate recycling ethanol concentrates to there not being the alcohol flavor, drying is ground into fine powder; Merge above-mentioned all extract powders, and add dextrin, mixing is granulated, drying, and granulate, tabletting promptly gets tablet.It is yellowish-brown to the brown granule, feeble QI perfume (or spice), mildly bitter flavor.

Claims (2)

1, a kind of Chinese patent medicine for the treatment of hepatic fibrosis and liver cirrhosis is characterized in that its raw material components and percentage by weight thereof:

Radix Curcumae 6-20 Polyporus 6-20 Radix Paeoniae Rubra 6-20 Pericarpium Citri Reticulatae Viride 6-15

Radix Aucklandiae 6-20 Pericarpium Arecae 6-20 Rhizoma Alismatis 6-20 Cortex Magnoliae Officinalis 6-15

Endothelium Corneum Gigeriae Galli 6-20 Carapax Trionycis 20-30

2, the preparation method of the preparation of the Chinese patent medicine of treatment hepatic fibrosis according to claim 1 and liver cirrhosis is characterized in that:

1) Endothelium Corneum Gigeriae Galli, Carapax Trionycis add 8-12 times of water gaging, decoct 4 times, and each 4 hours, filter, merging filtrate concentrates, and drying is ground into fine powder;

2) Polyporus adds 8-12 times of water gaging, decoct 3 times, and each 3 hours, filter, merging filtrate concentrates, and drying is ground into fine powder;

3) Radix Paeoniae Rubra, Radix Curcumae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, thick pouncing on (system), Pericarpium Arecae and Rhizoma Alismatis seven flavor medicine add 10-12 times of water gaging immersion 1 hour, and heating decocts 3 times, each 1 hour, filter, merging filtrate is concentrated into the clear paste that relative density is 1.10-1.20, adding ethanol makes the alcohol amount of containing reach 50-70%, stir evenly, leave standstill 24h, filter, filtrate recycling ethanol is to there not being the alcohol flavor, concentrate, drying is ground into fine powder;

4) merge above-mentioned all extract powders, and add dextrin, mixing is granulated, drying, and granulate is made tablet or granule or pill or capsule dosage form.