CN1274350C

CN1274350C - Combination of medication for curing burn and scald and preparation method

Info

Publication number: CN1274350C
Application number: CNB2004100296609A
Authority: CN
Inventors: 梁锁增
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-03-30
Filing date: 2004-03-30
Publication date: 2006-09-13
Anticipated expiration: 2024-03-30
Also published as: CN1562290A

Abstract

The present invention discloses a medicine composition for the treatment of burns and scalds and a preparation method thereof. The composition is mainly prepared from the raw material medicines of rhubarb, ailanthus fruit, anomalous wormwood, radix arnebiaemilk vetch, poppy shell, artemisia leaf, keel, borneol and benne oil. The preparation method of the present invention comprises: steeping the rhubarb, the ailanthus fruit, the anomalous wormwood, the radix arnebiae, the keel, the milk vetch, the poppy shell and the artemisia leaf in the benne oil for seven days; frying the medicines to dry; eliminating dregs; collecting medicine oil; adding yellow beeswax into the medicine oil in a pan; when the yellow beeswax totally melts, stirring the mixture without heating; when temperature decreases to 30 DEGC, adding the borneol; stirring the mixture until the mixture cools and condenses into a paste; putting the paste into a rubber tube. The composition of the present invention has the functions of the promotion of blood circulation for the removal of blood stasis, detumescence, pain alleviation, the elimination of decay and toxin, the regeneration of tissue for the healing of wounds and the resistance of fibrosis, and has conspicuous effect on the treatment of burns and scalds of different degrees.

Description

A kind of pharmaceutical composition for the treatment of burn and scald and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of burn and scald and preparation method thereof.

Background technology

In places such as family, enterprise, armies, the burn and scald accident happens occasionally, and the burn patient worries most is traumatic infection and cause septicemia to cause death when the treatment burn and scald, or stays cicatrix behind the burn wound healing.At present the treatment burn and scald has multiple medicine, generally during treatment adopts ointment for treating burn, but ointment for treating burn can not reach the effect that granulation promoting was invigorated blood circulation, restrained in antiinflammatory, sterilization, hemostasis rapidly.

Technology contents

The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of burn and scald.

Another object of the present invention is providing a kind of preparation of drug combination method for the treatment of burn and scald.

The present invention is achieved through the following technical solutions:

Choose crude drug:

Radix Et Rhizoma Rhei 30-100 weight portion Fructus Ailanthi 30-100 weight portion

Herba Artemisiae Anomalae 30-100 weight portion Radix Arnebiae (Radix Lithospermi) 15-50 weight portion

Radix Astragali 50-100 weight portion Plantula Papaveris 20-60 weight portion

Folium Artemisiae Argyi 3-20 weight portion Os Draconis 50-150 weight portion

Borneolum Syntheticum 50-150 weight portion Oleum Sesami 1500-4500 weight portion

Optimum ratio of the present invention is:

Radix Et Rhizoma Rhei 60 weight portion Fructus Ailanthi 60 weight portions

Herba Artemisiae Anomalae 60 weight portion Radix Arnebiae (Radix Lithospermi)s 35 weight portions

The Radix Astragali 75 weight portion Plantula Papaveris 40 weight portions

Folium Artemisiae Argyi 10 weight portion Os Draconis 100 weight portions

Borneolum Syntheticum 100 weight portion Oleum Sesami 3000 weight portions

Get Radix Et Rhizoma Rhei, Fructus Ailanthi, Herba Artemisiae Anomalae, Radix Arnebiae (Radix Lithospermi), Os Draconis, the Radix Astragali, Plantula Papaveris, Folium Artemisiae Argyi and put into Oleum Sesami and soak after 4-10 days, fried withered with common process, remove slag, medicine oil;

The oil of getting it filled adds 500-1200 weight portion Cera Flava, puts into pot and treats that wax dissolves to the greatest extent, stirs from fire to add Borneolum Syntheticum when temperature 15-45 spends; Stir to being condensed into cream, the flexible pipe of packing into gets final product.

The present composition adds conventional adjuvant and can be made into the clinical dosage form of accepting, any as in emplastrum, ointment, spray, the liniment etc.

The present composition has the pyretic toxicity of dispersing, activating blood circulation to dissipate blood stasis, and reducing swelling and alleviating pain is changed the decomposition poison, and granulation promoting is held back skin, and the effect of fibrosis is remarkable to the burn and scald effect for the treatment of various different depths.

Following experimental example is used to further specify the present invention.

The present invention increases the 559 routine clinical observations of mourning hall burn cream treatment burn and scald

The present invention increases the mourning hall burn cream and treats various burn and scald 559 examples from nineteen ninety-five, and clinical effectiveness is satisfied, and it is as follows now will treat the observation situation analysis.

1, clinical data

This organizes 559 examples, male's 293 examples wherein, women's 266 examples, 3 months～78 years old age.Patient burn was used burn cream of the present invention half an hour～99 day afterwards.289 examples of burn surface area 1%～10%, 10%～20%176 example, 20%～30%58 example, 30%～50%26 example, 10 examples more than 50%.Depth of burn: I degree 103 examples, shallow II degree 186 examples, dark II degree 205 examples, shallow IV degree 44 examples, dark N degree 21 examples.Burn cause: steam, hot water are scalded 393 examples, and 61 examples are hindered in rusting, flame burn 53 examples, electric burn 14 examples, Colophonium burn 3 examples, chemical burn 7 examples, gunpowder 28 examples of burning.

2, treatment

2,1 side's medicine is formed: Radix Et Rhizoma Rhei 60 grams, Fructus Ailanthi 60 grams, Herba Artemisiae Anomalae 60 grams, the Radix Arnebiae (Radix Lithospermi) 35 gram Radixs Astragali 75 grams, Plantula Papaveris 40 grams, Folium Artemisiae Argyi 10 grams, Os Draconis 100 grams, Borneolum Syntheticum 100 grams, Oleum Sesami 3000 grams; Get Radix Et Rhizoma Rhei, Fructus Ailanthi, Herba Artemisiae Anomalae, Radix Arnebiae (Radix Lithospermi), Os Draconis, the Radix Astragali, Plantula Papaveris, Folium Artemisiae Argyi and put into Oleum Sesami and soak after 7 days, fried withered with common process, remove slag, medicine oil; The oil of getting it filled adds 700 gram Cera Flava, puts into pot and treats that wax dissolves to the greatest extent, stirs from fire to add Borneolum Syntheticum when temperature 30 is spent; Stir to being condensed into cream, the flexible pipe of packing into promptly can be made into burn cream.

2,2 cure mainly: disperse pyretic toxicity, activating blood circulation to dissipate blood stasis, reducing swelling and alleviating pain is changed the decomposition poison, and granulation promoting is held back skin, and fibrosis is applicable to the burn and scald of various different depths.

2,3 Therapeutic Method: emergency treatment patient, wound surface is just being located extremely pain, and this moment, the surgery aseptic process of wound surface was not cleaned for a long time, should in time burn cream be applied to wound surface uniformly, the about 1mm of thickness treats thoroughly to remove dirt again under the situation of pain relief or patient's conditions permit.Discharge the soaked beancurd sheet that comes off and pile up of wiping out, look concrete condition and be coated with that cream exposes or pad pasting wrapping dressing, change dressings into every day 1 time or the next day 1 time, the liquefaction thing increases dressing change frequency for a long time, in time removes the liquefaction thing every day 2-3 time, guarantees that wound surface continues to supply medicine.The specification requirement of changing dressings will reach painless, not damaged is hemorrhage, nothing liquefaction thing retains and is criterion.Slough to dark II degree III degree wound surface will be created brokenly with scalpel ploughing and weeding formula as early as possible in length and breadth, creates conditions for the infiltration of medicine, to reach the quickening removing the necrotic tissue and promoting granulation, the purpose that the course of treatment is shortened in the epithelium healing.

3, result

This group case 80% is out-patient treatment, and 20% be hospitalization, the 47 routine prognosis situations of removing in 559 examples ominous (28 examples are interrupted in out-patient treatment, leave hospital in advance person's 18 examples of not asking the medicine again of band medicine, 1 example prescription on individual diagnosis the 3rd day is because of leukocyte＜1.5 * 10 ⁹/ L transfers from one hospital to another) outside, all the other are all cured, cure rate 91.2%, and the healing in 2-3 days of I degree wound surface, the healing in 5～8 days of shallow II degree wound surface, the healing in 14～20 days of dark II degree wound surface, the dark III degree of III degree wound surface was healing in 30～45 days.After in dark II degree III degree burn and scald 270 examples, having 7 examples more scar hyperplasia is arranged, account for 2.69%, wherein 10 deliquescing of 1 routine posting in time cicatrix cream, 6 examples of surplusing begin after 4 months to paste cicatrix cream in the generation cicatrix, after February, scleroma attenuate deliquescing in various degree.There is not 1 routine dysfunction.Among II, the III degree patient, wound surface the maximum is 32cm * 24cm, the epithelium healing, and no scar hyperplasia, epidermis is soft flat, and elasticity is good.

4, model case

The patient man, 26 years old, because of scalding prescription on individual diagnosis in 1 hour.The patient is come in by other people steady, and two orders can not be opened, and moan ceaselessly.Look the swollen as little bucket of patient's head, the ears hypertrophy loses earhole, the swollen seam that loses of order, both hands are swollen as inflation is bright, slough upper garment before, neck, back, all blisters between waist, two lower limb blisters six places, big as egg, lower limb are I～II degree, and right hand wrist skin takes off, and wound surface is red alternate with white, for shallow, dark II degree is hindered, right hand back, right side of neck IV degree is hindered, and right side cheek II degree is hindered, the dark II degree of auris dextra, the gross area 40% (women's head-ornaments neck 9%, both hands 5%, two upper limb 6%, trunk preceding 6%, behind the trunk 5%, both legs 4%, both feet 3%, both arms 2%), remove dirt immediately, remove face, cervical region is coated with cream and exposes, and surplus wound surface is coated with the wrapping of patch film monolayer bacteria reducing gauze.Have a medical check-up: the P110/ branch, BP14/8kPa, mind is clear.Behind the coating after 10 minutes pain obviously alleviate, pain was ended in 20 minutes, and is sincere tired sleepy.Regularly observe body temperature, heart rate, blood pressure, urine amount.The patient is quiet sleeping after 40 minutes, the painless meaning of back patient of waking up, and mind is clear, changes dressings every day and handles 3 times.See to the 3rd day patient's women's head-ornaments edema to disappear that binocular can be opened and look thing, body temperature, blood pressure, heart rate are all in normal range.Continue to smear burn cream of the present invention, shallow II degree wound surface desire decortication recovery from illness on the 7th, dark II degree, III degree wound surface slough begin liquefaction, and patient god is good.Diet is normal, advises its out-of-bed activity.The 16th day, all healings on the dark II degree wound surface, the 21st day, before the right finesse, a right side IV degree wound surface epithelium healing, so far more back skin was flat soft for all degree of depth wound surface, and wrist, movable the no function of neck influence.Advise it to leave hospital, hinder follow-up observation in back 5 months, the facial color of the leather of patient is as usual, and wrist cervical region functional activity is flexible, no scar hyperplasia, and all II, III degree wound surface skin are soft flat, and only the right hand is carried on the back fraction hypopigmentation, pale red speckle.

5, preparation curative effect of the present invention and advantage

5,1 effectively alleviates wound pain: wound surface is one of its cardinal symptom bitterly behind the burn and scald, and pain relieving is the first the most urgent requirement of patient, and pain time prolongs, and severe patient can cause tic, shock, causes his disease and increases the weight of the state of an illness.Cause the reason of wound pain: stimulate peripheral nerve behind (1) hot injury; (2) the wound surface teleneuron is exposed impaired; (3) microcirculation disturbance and aggressive infect; (4) group is known edema compressing etc.This group case 3-10 minute pain after wound surface is coated with burn cream is significantly alleviated or disappearance.It is to be the traditional Chinese herb medicine of substrate according to approximate sebum class Vegetable oil lipoprotein that the present invention increases the mourning hall burn cream; behind the coating wound surface; the neuroprotective tip is not subjected to the stimulation of extraneous undesirable element; the arrectores pilorum of spasm is relaxed; improve local microcirculation; thereby alleviate wound pain effectively, continue for medicine as long as ensure wound surface, whole therapeutic process all can carry out in painless.

5, fraud is gone in 2 burn cream potentiation of the present invention, protection wound surface, prevention infection; Behind the burn and scald, the inherent protection barrier of skin table is damaged, and body resistance descends, and the external microbe pathogenic bacterium can avail oneself of the opportunity to get in, and cause traumatic infection, even jeopardize patient's life.The present invention increases the mourning hall burn cream and has thoroughly blocked the chance that external pollution, microorganism and antibacterial are invaded wound surface, thereby has created the environment of a cleaning, low bacterium, for a good condition has been created in the reparation of promotion damaged tissue.

5,3 good effect of activating blood circulation and reducing swelling are helped the band organized renewing life of being retarded by silt, traditional dryness therapy (tincture powder) is tied the thick dried medicine crust of one deck on wound surface, the chance that making is retarded by silt is with organized renewing life seldom, make the histiocyte of being at death's door further dewater, final downright bad fully, downright bad wound surface that (layer) is not only stiff but also black of formation, last or diapyesis in scab comes off or imposes uniformity without examining individual cases it.In treatment, observe, the present invention increases the mourning hall burn cream with pH value neutrality, pair cell has good moist, Nutrition, and has the very strong function of dispersing pyretic toxicity, change silt detumescence, microcirculation improvement, the stasis of wound surface external stasis zone organizes diffusing the swelling of becoming silted up in general 1-7 days to disappear and multiple normal color after the coating, and hydrolysis, enzymolysis then took place after 4-5 days the wound surface slough that can not answer, and the liquefaction of going from the exterior into the interior is discharged, the cell that is at death's door in the district of being retarded by silt is moistened, and recovers life.

5,4 change silt softening the hard mass fibrosis: the cicatrix incidence rate is low behind dark II degree, the III degree wound healing, this organizes 270 routine deep burn wounds, except that 7 examples not on request regular treatment cause the cicatrix, soft flat, good, the no contracture of skin elasticity of all the other equal wound surface epitheliums healing back cicatrixes, there is not deformity, none routine dysfunction generation.The main cause of cicatrization is that epithelial cell and fibrocyte are out of proportion, the composition of the silt of having of the present invention, softening the hard mass, fibrosis, the undue growth that has suppressed the fibrosis tissue effectively, epithelial cell and fibrocellular ratio have been coordinated, impel skin heart regeneration, cooperate belt leather to stick wrapping simultaneously, dressing early early out-of-bed activity is taken exercise, thereby has avoided contracture, deformity, handicapped generation.

5, the burn of 5 privileged sites: can take to be coated with cream exposure or lagging wrapping dressing according to the difference at position, early movable the exercise is difficult for disabling.This paper passes through 1.08 routine handss, 76 example foots, 21 regular meeting the moon, 146 routine knee joints, elbow, ankle joint, the treatment of 31 routine cervical regions, in time movable the exercise, impel blood circulation and tissue metabolism, accelerate the healing of wound surface, and can make fibrous tissue resilience direction aligned growth, avoided the influence of cicatrix function of joint.

Observe confirmation by the clinical use of 559 routine fire victims, pH value neutrality of the present invention, penetration is extremely strong; easily be coated with, easily be organized absorption; easy cleaning, external is for oral administration all to have no side effect, and has the pharmacological action of antiinflammatory for oral administration, promoting blood circulation and stopping pain, protection mucosa, healing treatment.

Embodiment 1

Radix Et Rhizoma Rhei 60g Fructus Ailanthi 60g Herba Artemisiae Anomalae 60g Radix Arnebiae (Radix Lithospermi) 35g

Radix Astragali 75g Plantula Papaveris 40g Folium Artemisiae Argyi 10g Os Draconis 100g

Borneolum Syntheticum 100g Oleum Sesami 3000g

Get Radix Et Rhizoma Rhei, Fructus Ailanthi, Herba Artemisiae Anomalae, Radix Arnebiae (Radix Lithospermi), Os Draconis, the Radix Astragali, Plantula Papaveris, Folium Artemisiae Argyi and put into Oleum Sesami and soak after 7 days, fried withered with common process, remove slag, medicine oil; The oil of getting it filled adds 700g Cera Flava, puts into pot and treats that wax dissolves to the greatest extent, stirs from fire to add Borneolum Syntheticum when temperature 30 is spent; Stir to being condensed into cream, the flexible pipe of packing into gets final product.Every pipe 30-50g, every day 1-2 time, even coating 1 millimeters thick in the affected part.

Embodiment 2

Radix Et Rhizoma Rhei 30g Fructus Ailanthi 30g Herba Artemisiae Anomalae 30g Radix Arnebiae (Radix Lithospermi) 15g

Radix Astragali 50g Plantula Papaveris 20g Folium Artemisiae Argyi 3g Os Draconis 50g

Borneolum Syntheticum 50g Oleum Sesami 1500g

Said medicine technology is routinely made spray.

Embodiment 3

Radix Et Rhizoma Rhei 100g Fructus Ailanthi 100g Herba Artemisiae Anomalae 100g Radix Arnebiae (Radix Lithospermi) 50g

Radix Astragali 100g Plantula Papaveris 60g Folium Artemisiae Argyi 20g Os Draconis 150g

Borneolum Syntheticum 150g Oleum Sesami 4500g

Said medicine technology is routinely made emplastrum.

Claims

1, a kind of pharmaceutical composition for the treatment of burn and scald, its feature is made up of following crude drug in said composition:

Radix Astragali 50-100 weight portion Plantula Papaveris 20-60 weight portion

Folium Artemisiae Argyi 3-20 weight portion Os Draconis 50-150 weight portion

Borneolum Syntheticum 50-150 weight portion Oleum Sesami 1500-4500 weight portion.

2, pharmaceutical composition according to claim 1 is characterized in that said composition is made up of following crude drug:

Radix Et Rhizoma Rhei 60 weight portion Fructus Ailanthi 60 weight portions

The Radix Astragali 75 weight portion Plantula Papaveris 40 weight portions

Folium Artemisiae Argyi 10 weight portion Os Draconis 100 weight portions

Borneolum Syntheticum 100 weight portion Oleum Sesami 3000 weight portions.

3, pharmaceutical composition according to claim 1 and 2 is characterized in that said composition adds conventional adjuvant and makes the clinical emplastrum of accepting, ointment, spray or liniment.

4, preparation of drug combination method according to claim 1 and 2 is characterized in that this preparation method is:

Get Radix Et Rhizoma Rhei, Fructus Ailanthi, Herba Artemisiae Anomalae, Radix Arnebiae (Radix Lithospermi), Os Draconis, the Radix Astragali, Plantula Papaveris, Folium Artemisiae Argyi and put into after Oleum Sesami soaked 4-10 days, fried withered with common process, remove slag, medicine oil;

5, preparation of drug combination method according to claim 4 is characterized in that this preparation method is:

Get Radix Et Rhizoma Rhei, Fructus Ailanthi, Herba Artemisiae Anomalae, Radix Arnebiae (Radix Lithospermi), Os Draconis, the Radix Astragali, Plantula Papaveris, Folium Artemisiae Argyi and put into after Oleum Sesami soaked 7 days, fried withered with common process, remove slag, medicine oil;

The oil of getting it filled adds 700 weight portion Cera Flava, puts into pot and treats that wax dissolves to the greatest extent, stirs from fire to add Borneolum Syntheticum when temperature 30 is spent; Stir to being condensed into cream, the flexible pipe of packing into gets final product.