CN1273178C - 一种治疗类风湿性关节炎的中药组合物 - Google Patents
一种治疗类风湿性关节炎的中药组合物 Download PDFInfo
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Abstract
Description
组别 | 剂量(g/kg) | 鼠数 | 肿胀度(mm, X±S) | ||
15min | 30min | 4h | |||
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 31.50.75素66ug | 1010101010 | 1.7±0.21.0±0.2***1.3±0.2***1.4±0.4*1.0±0.2*** | 2.1±0.41.5±0.3***1.7±0.2**1.7±0.3**1.2±0.4*** | 1.6±0.21.0±0.2***1.2±0.2***1.3±0.2***1.0±0.2*** |
组别 | 剂量(g/kg) | 鼠数 | 肿胀度(mm, X±S) | ||
12h | 24h | 72h | |||
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 31.50.75甲素66ug | 1010101010 | 2.1±0.41.3±0.3***1.6±0.3***1.7±0.3**1.3±0.3*** | 2.1±0.41.6±0.2***1.8±0.2***2.0±0.3***1.6±0.2*** | 2.3±0.41.4±0.3***1.7±0.3***1.8±0.3***1.4±0.3*** |
组别 | 剂量(g/kg) | 鼠数 | 给佐剂后左足跖肿胀度(ml) | |||
8日 | 13日 | 18日 | 23日 | |||
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 31.50.75甲素66ug | 88888 | 0.34±0.060.28±0.05**0.30±0.06*0.32±0.05*0.28±0.04** | 0.41±0.050.30±0.05***0.33±0.06**0.37±0.05*0.31±0.05*** | 0.42±0.050.30±0.06***0.33±0.04***0.37±0.04**0.31±0.05*** | 0.34±0.050.27±0.05**0.29±0.04**0.32±0.03*0.27±0.05** |
组别 | 剂量(g/kg) | 鼠数 | 给佐剂后左足跖肿胀度(ml) | ||
15日 | 20日 | 25日 | |||
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 31.50.75甲素66ug | 88888 | 0.24±0.060.15±0.04***0.17±0.04**0.20±0.03*0.15±0.03*** | 0.26±0.070.14±0.04***0.18±0.06**0.20±0.03**0.15±0.03*** | 0.21±0.050.12±0.03***0.15±0.03***0.17±0.04*0.12±0.02*** |
组别 | 剂量(g/kg) | 鼠数 | 给佐剂后体重(g, X±S) | ||
0日 | 15日 | 25日 | |||
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 31.50.75甲素66ug | 88888 | 184±7183±7186±6185±7185±7 | 190±8199±9198±9195±7200±7** | 194±9209±9***207±9**202±7208±7*** |
组别 | 剂量(g/kg) | 给药途径 | 鼠数 | 腹腔透出染料吸收度值 X±S | 抑制率(%) | P |
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组氢化可的松组 | 31.50.750.02 | ig1gigim | 108797 | 0.172±0.0910.101±0.0210.116±0.0640.110±0.0230.153±0.054 | 41.332.636.011.0 | <0.05>0.05>0.05>0.05 |
组别 | 剂量(g/kg) | 鼠数 | CMC囊中白细胞数(109/L) | |
3小时 | 7.5小时 | |||
对照组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 42甲素66ug | 6666 | 11.4±5.68.7±1.95.6±2.1**7.8±2.0 | 18.8±9.012.8±7.512.2±3.313.3±2.8 |
组别 | 剂量(g/kg) | 鼠数 | 肉芽肿(mg) | P |
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 31.50.75甲素66ug | 1010101010 | 99.8±16.581.0±5.484.5±5.398.3±16.182.2±11.0 | <0.01<0.05>0.05<0.05 |
组别 | 剂量(g/kg) | 鼠数 | 反应时(秒) | 变化率(%) | P |
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 31.50.75甲素66ug | 1010101010 | 22.1±5.864.1±7.946.5±8.238.6±6.865.8±7.5 | 100290210175298 | <0.01<0.01<0.01<0.01<0.01 |
组别 | 剂量(g/kg) | 鼠数 | 扭体次数( X±SD) | 抑制率(%) | P |
对照组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组雷公藤组 | 31.50.75甲素66ug | 1010101010 | 48.4±8.811.3±4.518.1±6.722.7±7.610.6±4.5 | 76.662.653.178.1 | <0.01<0.01<0.01<0.01 |
组别 | 剂量(g/kg) | 鼠数 | OD值 |
对照组模型组本发明胶囊剂组本发明胶囊剂组强的松组 | 52.55mg | 66666 | 0.24±0.01***0.87±0.030.48±0.03***0.54±0.01***0.34±0.02*** |
组别 | 剂量(g/kg) | 鼠数 | 细胞数(%) | L3T4 +/Lyt-2+ | |
L3T4 + | Lyt-2+ | ||||
对照组模型组本发明胶囊剂组本发明胶囊剂组本发明胶囊剂组强的松组 | 52.51.255mg | 666666 | 54.1±1.964.9±4.662.7±3.767.5±4.269.7±3.759.6±7.5 | 45.6±2.740.3±2.147.7±5.445.4±3.040.0±2.556.2±3.8*** | 1.19±0.07***1.56±0.101.34±0.28**1.49±0.141.53±0.101.21±0.14*** |
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CN101698072B (zh) * | 2009-10-30 | 2015-05-13 | 浙江医药高等专科学校 | 一种治疗风湿关节炎的中药组合物及其制备方法 |
CN104248676A (zh) * | 2014-09-30 | 2014-12-31 | 韦振良 | 治疗风湿的药物及其制备方法 |
CN104547086A (zh) * | 2015-01-30 | 2015-04-29 | 王桂霞 | 一种治疗类风湿性关节炎的中药组合物 |
CN107496614A (zh) * | 2017-08-17 | 2017-12-22 | 成都新柯力化工科技有限公司 | 一种用于骨修复和镇痛的中药贴及其制备方法 |
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