CN1266712A - Oral liquid for preventing altitude disease and its preparing process - Google Patents
Oral liquid for preventing altitude disease and its preparing process Download PDFInfo
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- CN1266712A CN1266712A CN99126671A CN99126671A CN1266712A CN 1266712 A CN1266712 A CN 1266712A CN 99126671 A CN99126671 A CN 99126671A CN 99126671 A CN99126671 A CN 99126671A CN 1266712 A CN1266712 A CN 1266712A
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Abstract
An oral liquid for preventing altitude disease contains the fermented product of grass and serves to lower the oxygen consumption, improve metabolism, increase the saturation degree of blood oxygen, regulate cardiovascular function, correct the metabolism disorder of free radicals and increase hypoxic tolerance,so preventing altitude disease.
Description
The invention relates to a kind of oral liquid that prevents altitude sickness and preparation method thereof, more particularly prevent oral liquid of altitude sickness and preparation method thereof about a kind of aqueous solution of the fermented product of grass that adopts.
Altitude environment has a strong impact on people's healthy and work efficiency, and principal element is a hypoxia.People from Plain arrives behind the plateau often because of the acute and chronic altitude sickness takes place hypoxia, and as plateau pneumochysis, altitude coma, high altitude heart disease, high altitude erythrocytosis etc., if untimely treatment will cause death, it is very important therefore preventing altitude sickness.
Facts have proved that altitude sickness can be prevented.Medicine is one of effective measures of prevention altitude sickness.At present, at home, mainly contain FUFANG DANGSHEN PIAN, Rhodiola root oral liquid, Radix Codonopsis, Radix Ginseng etc.But above-mentioned medicine is a Chinese medicine all, and based on inrigorating qi and promoting blood circulation, and price is more expensive.Abroad, based on diuretic, first-selected acetazolamide, this medicine has giddy, side effect such as actinal surface numbness, paraesthesia.
One of purpose of the present invention provides and a kind ofly can reduce oxygen consumption, improves the energy metabolism level, increases blood oxygen saturation, regulates cardiovascular function, corrects the Radical Metabolism disorder, improves oral liquid or other dosage form of body to the prevention altitude sickness of hypoxic tolerance.
Two of purpose of the present invention provides a kind of preparation method of preventing the oral liquid of altitude sickness.
These and other objects of the present invention will and be described and further set forth by following detailed description.
The oral liquid of prevention altitude sickness of the present invention contains the aqueous solution of the fermented product of grass, and described grass can be Fructus Hordei Germinatus, corn etc.
In the oral liquid of prevention altitude sickness of the present invention, Fructus Hordei Germinatus fermented product or Semen Maydis fermented product and water consumption are every gram fermented products with 10～60 ml waters; The aqueous solution of the fermented product of above-mentioned a kind of grass can be used separately, also use can be mixed; As mixing use, the weight part ratio of the aqueous solution of Fructus Hordei Germinatus fermented product and the aqueous solution of Semen Maydis fermented product is 5～50: 10～40; Fermented product adopts aspergillus niger as strain.
In the present invention, described Fructus Hordei Germinatus fermented product outward appearance is dark brown, water-soluble, flavor perfume, reducing sugar about 3%, total sugar 20%, acidity 10%, pH value 2～3, about protein content 20%, moisture content 6% contains polypeptide, aminoacid, polysaccharide and organic acid in addition; Described Semen Maydis fermented product outward appearance be the colourless crystallization body, the flavor sweet, in water dissolubility greater than 50 grams per milliliters, in alcohol greater than 0.8, be insoluble to ether, pH value is 2.0～4.0, contains gluconic acid, sugar and esters in addition.
The preparation method of the oral liquid of prevention altitude sickness of the present invention, wherein Fructus Hordei Germinatus fermented product prepares by the following method:
A, 100 kilograms of Fructus Hordei Germinatus 50 orders are pulverized, and add 500 kg of water, and through 60 ℃, saccharifying in 1 hour is filtered;
B, get 100 milliliters of beerworts, add 3% agar, pack in vitro, 120 ℃ of sterilizations 20 minutes test tube deduction inclined-plane, insert aspergillus niger after 2 days, 28 ℃ cultivated 4 days slant strains;
C, get 150 milliliters of beerworts, put into 750 milliliters of triangular flasks and add 25 milliliters of NH
4Cl sterilized 20 minutes for 120 ℃, and the cooling back is inserted slant strains and become I level seed, and ratio is that 5% (100 parts of I level seeds insert 5 parts of inclined-plane kinds) gets I level seed; ,
D, get 400 liters of beerworts, put into 500 liters of fermentation tanks and add 2 kilograms of NH
4Cl sterilized 30 minutes for 120 ℃, and I level seed is inserted in the cooling back, and ratio is 5%, at tank pressure 1Kg/cm
2, under 30 ℃ of conditions of temperature, became II level seed through 2 days;
E, diastatic Fructus Hordei Germinatus juice (is added 2 kilograms of NH by 400 liters
4The Cl ratio) put into big fermentation tank, 120 ℃ of sterilizations 30 minutes all are put into II level seed in the big fermentation tank after being cooled to 30 ℃ and ferment 40 ℃ of temperature, ventilation 1: 0.5, pressure 1Kg/cm
2, 100 hours time,, can get fermented product more than 60 kilograms at last by fermentation:
F, at last at 100 ℃, vacuum concentration is to thick paste under the atmospheric pressure, pulverize dry or oven dry back under vacuum or spray condition if necessary.
The preparation method of the oral liquid of prevention altitude sickness of the present invention, wherein Semen Maydis fermented product prepares by the following method:
A, get 100 kilograms of starch, add 700 kg of water, add amylase under 60 ℃ of conditions by 5 units/gram, saccharifying 30 minutes;
B, get glucose 30 gram, peptone 0.25 gram, KH
2PO
40.12 gram, CaCO
34 grams, 400 milliliters of potato juices, agar 25 grams add water to 1 liter, are divided in vitro, sterilize 30 minutes for 120 ℃, put into the inclined-plane, and inoculated aspergillus niger after 4 days is cultivated for 30 ℃ and was got slant strains in 6 days;
Add 400 liters of starch saccharifications in C, 500 liters of fermentation tanks, add glucose 120 grams, KH in grams per liter starch saccharification ratio
2PO
40.2 gram, MgSO
40.15 gram, CaCO
326 restrain in jar, and 90 ℃ of sterilizations of normal pressure 30 minutes insert the inclined-plane kind when being cooled to 30 ℃, and ratio is 5% (100 parts of I level kinds inserts 5 parts of slant strains), cultivates tank pressure 0.5Kg/cm 36 hours
2Get I level seed;
D, in big fermentation tank (5 tons of fermentation tanks are put 4 tons of starch saccharifications), add KH in the grams per liter ratio
2PO
40.2 gram, MgSO
40.15 gram, glucose 120 grams, CaCO
326 restrain in jar, sterilize 30 minutes for 100 ℃, after the stirring cooling, I level kind all are put in the big fermentation tank, ferment pressure 1Kg/cm 24 hours
2, post-heating added lime cream to 100 degree and stirring in 24 hours, made calcium gluconate reach 200 grams per liters, was cooled to 20 ℃, and centrifugalize goes out the calcium gluconate crystal, can get dry more than 70 kilograms through fermentation.
E, press 3 liters of distilled water, 3 liters of concentrated sulphuric acids, 2.45 kilograms of ratios of calcium gluconate are put into retort successively, reaction centrifugal decalcification after 8 hours under 40 ℃ of conditions;
F, centrifugal liquid are through 50 ℃ of temperature, and vacuum 700mmHg is concentrated into thick shape, dry or oven dry back pulverizing under vacuum or spray condition if necessary.
Product of the present invention can reduce oxygen consumption, improves the energy metabolism level, increases blood oxygen saturation, regulates cardiovascular function, corrects the Radical Metabolism disorder, improves body to hypoxic tolerance, the prevention altitude sickness.
Fructus Hordei Germinatus fermented product is the microbial fermentation product with the corn starch thing, and using separately has tangible antioxidant effect, and the prevention altitude sickness is had certain effect, and the two mixes use by a certain percentage, and effect is more obvious.
Product animal experiment proof of the present invention can improve the anoxybiotic animal dis motility rate of decompression more than 35%, prolongs the airtight anoxia animals survived time more than 50%.
One, to the anxious effect of giving birth to anoxia endurance of white mice
Decompression anoxia and airtight anoxia animal dis motility rate and time-to-live are important indicators estimating the body anoxia tolerance both at home and abroad as a whole.
Decompression anoxia method: laboratory animal Kunming kind white mice, male, body weight 18～20 grams, divide two groups at random by body weight, preceding 40 minutes of anoxia, (0.2ml/ only for medicine group and this medicine of matched group difference lumbar injection, 200mg/ml) with the equivalent normal saline, anoxia height ten thousand metres, the rate of climb 15 meter per seconds rise to 3000 meters and 8000 meters and stopped respectively 3 minutes and 5 minutes, rise to final height, observe animal dead rate in 1 hour.
The airtight anoxia method: laboratory animal, dosage, method and approach are the same, and it is 180 milliliters triangular flask that animal is put into band rubber closure volume, puts 7 gram soda lime in the bottle, the sealing of jumping a queue, observation death time of animal.
Influence to the white mice anoxia endurance
| Group | The decompression anoxia | Airtight anoxia | ||||
| Animal (only) | Survival rate (%) | Improve (%) | Animal (only) | Survival rate (%) | Improve (%) | |
| The medicine group | ????21 | ??76.2 | ??38.1 | ????22 | ?45.0± ????8.4 | ??53.8 |
| Matched group | ????21 | ??38.1 | ????22 | ?20.8± ????3.0 | ||
Two, toxicity test
White mice, body weight 20～22 grams, divide lumbar injection and irritate the stomach group, each 10 of animals, lumbar injection dosage are 100 milligrams/(being equivalent to 40 times of human body consumptions every day), and irritating stomach dosage is 500 milligrams/(being equivalent to 20 times of human body consumptions every day), observed 3 days, death and side effect do not take place in the white mice well-grown, and LD50 is more than or equal to 10 gram/kilograms.
Oral liquid of the present invention can be routinely pharmaceutical technology, add pharmaceutical adjuvants such as conventional excipient, flavoring agent, disintegrating agent, antiseptic, lubricant, binding agent, solvent, thickening agent, wetting agent, make any dosage form that is suitable for clinical use, as tablet, granule, capsule, injection etc.
Below further specify the present invention by specific embodiment.
In the present invention, refer in particular to as non-, all units are unit of weight.
Example 1
The technical process of Fructus Hordei Germinatus powder is shown in figure (1):
Fructus Hordei Germinatus powder inserts into I level seed through the saccharifying filtration with the inclined-plane kind, inserts into II level seed mixture in succession and enters fermentation tank jointly, and mixture takes out drying after concentrating, become powder (capsule); Also can with concentrated solution again thin up become oral liquid.Its per step specification requirement is:
Prepare Fructus Hordei Germinatus fermented product according to the following steps:
100 kilograms of Fructus Hordei Germinatus 50 orders are pulverized, added 500 kg of water, through 60 ℃, saccharifying in 1 hour is filtered, and by fermentation, can get fermented product more than 60 kilograms at last.
Slant strains: get 100 milliliters of beerworts, add 3% agar, pack in vitro, sterilized 20 minutes for 120 ℃,, insert aspergillus niger after 2 days, cultivated 4 days for 28 ℃ test tube deduction inclined-plane:
I level seed: get 150 milliliters of beerworts, put into 750 milliliters of triangular flasks and add 25 milliliters of NH
4Cl sterilized 20 minutes for 120 ℃, and the cooling back is inserted slant strains and become I level seed, and ratio is 5% (100 parts of I level seeds inserts 5 parts of inclined-plane kinds);
II level seed: get 400 liters of beerworts, put into 500 liters of fermentation tanks and add 2 kilograms of NH
4Cl sterilized 30 minutes for 120 ℃, and I level seed is inserted in the cooling back, and ratio is 5%, at tank pressure 1Kg/cm
2, under 30 ℃ of conditions of temperature, became II level seed through 2 days;
Fermentation: diastatic Fructus Hordei Germinatus juice (adds 2 kilograms of NH by 400 liters
4The Cl ratio) put into big fermentation tank, 120 ℃ of sterilizations 30 minutes, lowering the temperature all is put into II level seed in the big fermentation tank 40 ℃ of fermentation temperatures, ventilation 1: 0.5, pressure 1kg/cm after 30 ℃
2, 100 hours time;
Concentrate: 100 ℃, an atmospheric pressure vacuum concentration is to thick paste;
Dry: pulverize vacuum or spray drying or oven dry back.
The technical process of Semen Maydis powder is shown in figure (2):
Starch inserts into I level seed through saccharifying filtration and inclined-plane kind, is mixed into fermentation tank, through decalcification, concentrated, dry, gets product again.Its per step specification requirement is:
Prepare the corn starch fermented product according to the following steps:
100 kilograms of starch add 700 kg of water, add amylase by 5 units/gram, and under 60 ℃ of conditions, saccharifying 30 minutes through technologies such as fermentations, can get dry more than 70 kilograms.
Slant strains: glucose 30 grams, peptone 0.25 gram, KH
2PO
40.12 gram, CaCO
34 grams, 400 milliliters of potato juices, agar 25 grams add water to 1 liter, are divided in vitro, sterilize 30 minutes for 120 ℃, put into the inclined-plane, and inoculated aspergillus niger after 4 days was cultivated 6 days for 30 ℃:
I level seed: add 400 liters of starch saccharifications in 500 liters of fermentation tanks, add glucose 120 grams, KH in grams per liter starch saccharification ratio
2PO
40.2 gram, MgSO
10.15 gram, CaCO
326 restrain in jar, and 90 ℃ of sterilizations of normal pressure 30 minutes insert the inclined-plane kind when cooling off 30 ℃, and ratio is 5% (100 parts of I level kinds inserts 5 parts of inclined-plane bacterium), cultivates tank pressure 0.5Kg/cm 36 hours
2
Fermentation: in big fermentation tank (5 tons of fermentation tanks are put 4 tons of starch saccharifications), add KH by grams per liter
2PO
40.2 gram, MgSO
40.15 gram, glucose 120 grams, CaCO
326 grams, in jar, 100 ℃ of sterilizations 30 minutes, stir cooling after, I level kind all was put in the big fermentation tank fermentation 24 hours, pressure 1Kg/cm
2, post-heating added lime cream to 100 degree and stirring in 24 hours, made calcium gluconate reach 200 grams per liters, cooled off 20 ℃, and centrifugalize goes out the calcium gluconate crystal;
Decalcification: press 3 liters of distilled water, 3 liters of concentrated sulphuric acids, 2.45 kilograms of ratios of calcium gluconate are put into retort successively, and reaction is centrifugal after 8 hours under 40 ℃ of conditions;
Concentrate: centrifugal liquid is through 50 ℃ of temperature, and vacuum 700mmHg is concentrated into thick shape;
Dry: pulverize vacuum or spray drying or oven dry back.
Example 2
Repeat above-mentioned step, only final step for will above-mentioned Fructus Hordei Germinatus fermented product 50 grams and Semen Maydis fermented product 100 restrain behind the conventional auxiliary agent of adding in vacuum 700mmHg, after 80 ℃ of dryings of temperature, 16 orders sieve and make capsule product.
Claims (10)
1, a kind of oral liquid that prevents altitude sickness is characterized in that containing the aqueous solution of the fermented product of grass.
2, the oral liquid of prevention altitude sickness as claimed in claim 1 is characterized in that described grass can be Fructus Hordei Germinatus, corn etc.
3, the oral liquid of prevention altitude sickness as claimed in claim 1 is characterized in that Fructus Hordei Germinatus fermented product or Semen Maydis fermented product and water consumption are every gram fermented products with 10～60 ml waters.
4, the oral liquid of prevention altitude sickness as claimed in claim 1 is characterized in that oral liquid can be the aqueous solution that uses the fermented product of above-mentioned a kind of grass separately, also can be to mix to use.
5, the oral liquid of prevention altitude sickness as claimed in claim 4 is characterized in that the weight part ratio of the aqueous solution of the aqueous solution of Fructus Hordei Germinatus fermented product and Semen Maydis fermented product is 5～50: 10～40.
6,, it is characterized in that described fermented product adopts aspergillus niger as strain as the oral liquid of claim 1,2 described prevention altitude sickness.
7, as the oral liquid of claim 1,2 described prevention altitude sickness, it is characterized in that described Fructus Hordei Germinatus fermented product outward appearance is dark brown, water-soluble, flavor perfume, about reducing sugar 3%, about total sugar 20%, acidity 10%, pH value 2～3, protein content about 20%, moisture content 6% contains polypeptide, aminoacid, polysaccharide and organic acid in addition.
8, as the oral liquid of claim 1,2 described prevention altitude sickness, it is characterized in that described Semen Maydis fermented product outward appearance is that colourless crystallization body, flavor are sweet, in water dissolubility greater than 50 grams per milliliters, in alcohol greater than 0.8, be insoluble to ether, pH value is 2.0～4.0, contains gluconic acid, sugar and esters in addition.
9, as the preparation method of the oral liquid of claim 1,2 described prevention altitude sickness, it is characterized in that described Fructus Hordei Germinatus fermented product prepares by the following method:
A, 100 kilograms of Fructus Hordei Germinatus 50 orders are pulverized, and add 500 kg of water, and through 60 ℃, saccharifying in 1 hour is filtered;
B, get 100 milliliters of beerworts, add 3% agar, pack in vitro, 120 ℃ of sterilizations 20 minutes test tube deduction inclined-plane, insert aspergillus niger after 2 days, 28 ℃ cultivated 4 days slant strains;
C, get 150 milliliters of beerworts, put into 750 milliliters of triangular flasks and add 25 milliliters of NH
4Cl sterilized 20 minutes for 120 ℃, and the cooling back is inserted slant strains and become I level seed, and ratio is that 5% (100 parts of I level seeds insert 5 parts of inclined-plane kinds) gets I level seed;
D, get 400 liters of beerworts, put into 500 liters of fermentation tanks and add 2 kilograms of NH
4Cl sterilized 30 minutes for 120 ℃, and I level seed is inserted in the cooling back, and ratio is 5%, at tank pressure 1Kg/cm
2, under 30 ℃ of conditions of temperature, became II level seed through 2 days;
E, diastatic Fructus Hordei Germinatus juice (is added 2 kilograms of NH by 400 liters
4The Cl ratio) put into big fermentation tank, 120 ℃ of sterilizations 30 minutes all are put into II level seed in the big fermentation tank after being cooled to 30 ℃ and ferment 40 ℃ of temperature, ventilation 1: 0.5, pressure 1Kg/cm
2, 100 hours time,, can get fermented product more than 60 kilograms at last by fermentation;
F, at last at 100 ℃, vacuum concentration is to thick paste under the atmospheric pressure, pulverize dry or oven dry back under vacuum or spray condition if necessary.
10, as the preparation method of the oral liquid of claim 1,2 described prevention altitude sickness, it is characterized in that described Semen Maydis fermented product prepares by the following method:
A, get 100 kilograms of starch, add 700 kg of water, add amylase by 5 units/gram, under 60 ℃ of conditions, saccharifying 30 minutes;
B, get glucose 30 gram, peptone 0.25 gram, KH
2PO
40.12 gram, CaCO
34 grams, 400 milliliters of potato juices, agar 25 grams add water to 1 liter, are divided in vitro, sterilize 30 minutes for 120 ℃, put into the inclined-plane, and inoculated aspergillus niger after 4 days is cultivated for 30 ℃ and was got slant strains in 6 days;
Add 400 liters of starch saccharifications in C, 500 liters of fermentation tanks, add glucose 120 grams, KH in grams per liter starch saccharification ratio
2PO
40.2 gram, MgSO
40.15 gram, CaCO
326 restrain in jar, and 90 ℃ of sterilizations of normal pressure 30 minutes insert the inclined-plane kind when being cooled to 30 ℃, and ratio is 5% (100 parts of I level kinds inserts 5 parts of slant strains), cultivates tank pressure 0.5Kg/cm 36 hours
2Get I level seed;
D, in big fermentation tank (5 tons of fermentation tanks are put 4 tons of starch saccharifications), add KH in the grams per liter ratio
2PO
40.2 gram, MgSO
40.15 gram, glucose 120, CaCO
326 restrain in jar, sterilize 30 minutes for 100 ℃, after the stirring cooling, I level kind all are put in the big fermentation tank, ferment pressure 1Kg/cm 24 hours
2, post-heating added lime cream to 100 degree and stirring in 24 hours, made calcium gluconate reach 200 grams per liters, was cooled to 20 ℃, and centrifugalize goes out the calcium gluconate crystal, through fermentation, can get dry more than 70 kilograms.
E, press 3 liters of distilled water, 3 liters of concentrated sulphuric acids, 2.45 kilograms of ratios of calcium gluconate are put into retort successively, reaction centrifugal decalcification after 8 hours under 40 ℃ of conditions;
F, centrifugal liquid are through 50 ℃ of temperature, and vacuum 700mmHg is concentrated into thick shape, dry or oven dry back pulverizing under vacuum or spray condition if necessary.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99126671A CN1090916C (en) | 1999-12-24 | 1999-12-24 | Oral liquid for preventing altitude disease and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99126671A CN1090916C (en) | 1999-12-24 | 1999-12-24 | Oral liquid for preventing altitude disease and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1266712A true CN1266712A (en) | 2000-09-20 |
| CN1090916C CN1090916C (en) | 2002-09-18 |
Family
ID=5284504
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99126671A Expired - Fee Related CN1090916C (en) | 1999-12-24 | 1999-12-24 | Oral liquid for preventing altitude disease and its preparing process |
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| Country | Link |
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| CN (1) | CN1090916C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106170838A (en) * | 2014-04-25 | 2016-11-30 | 株式会社自动网络技术研究所 | chip and reactor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130531A (en) * | 1995-12-07 | 1996-09-11 | 青海省老年医学研究所 | Medicine for preventing and curing altitude disease |
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1999
- 1999-12-24 CN CN99126671A patent/CN1090916C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106170838A (en) * | 2014-04-25 | 2016-11-30 | 株式会社自动网络技术研究所 | chip and reactor |
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| Publication number | Publication date |
|---|---|
| CN1090916C (en) | 2002-09-18 |
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