CN1265823C - Health-care spray for treating acute injury, chronic strain, rheumatalgia - Google Patents
Health-care spray for treating acute injury, chronic strain, rheumatalgia Download PDFInfo
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- CN1265823C CN1265823C CN 200410010093 CN200410010093A CN1265823C CN 1265823 C CN1265823 C CN 1265823C CN 200410010093 CN200410010093 CN 200410010093 CN 200410010093 A CN200410010093 A CN 200410010093A CN 1265823 C CN1265823 C CN 1265823C
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- radix
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Abstract
The present invention relates to a health-care spray agent for treating acute injury, chronic strain and rheumatalgia, which is characterized in that the recipe of the health-care spray agent is composed of the following rates by weight of raw materials of 4.5% to 4.9% of clematis, 4.5% to 4.9% of angelica, 4.5% to 4.9% of red peony, 6.9% to 7.3% of dahurian angelica, 9.2% to 9.6% of rhizoma corydalis, 4.5% to 4.9% of safflower, 4.5% to 4.9% of pubescent angelica roots, 4.5% to 4.9% of notopterygium roots, 4.6% to 5.0% of medicinal achyranthes, 4.6% to 5.0% of camphor, 2.3% to 2.5% of borneol, 5.6% to 5.9% of asarum, 4.6% to 5.0% of sappanwood, 4.6% to 5.0% of spatholobus stems, 4.6% to 5.0% of myrrh, 5.5% to 5.9% of radix notoginseng, 4.6% to 5.0% of lu tong, 4.6% to 5.0% of pawpaw, 4.6% to 5.0% of homalonemae rhizoma and 4.5% to 4.9% of orientvine stems. When the health-care spray agent of the present invention is matched with oral medicine for treatment, the health-care spray agent reinforces an antalgic effect, enhances a therapeutic effect and shortens a therapeutic course. The present invention has the characteristics of simplicity, convenience, low price and good effects.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine, relate to a kind of health care spray that is used for the treatment of acute injury, chronic strain, rheumatism class pain specifically.
(2) background technology
Acute injury, chronic strain, rheumatism class pain are the common pathological phenomenons, all are main performance with pain.The acute and chronic trauma traditional Chinese medical science thinks that pathogenesis belongs to the stasis of blood, the damp and hot exopathogen numbness resistance of the sick pathogenesis wind and cold of rheumatism numbness meridians, and it is obstructed all to cause passages through which vital energy circulates, " stagnation of QI and blood may bring about pain " symptom occurs.Though because symptoms such as acute injury, chronic strain, rheumatism class pain can cause certain harmful effect with democratic meeting to the normal work of people, generally can people's life security not constituted a threat to, Just because of this, this type of disease is just often ignored by people.In the course of time, just can cause habitual damage and pathological changes.
(3) summary of the invention
Purpose of the present invention is just at above-mentioned disease, the basic rule of treatment of the traditional Chinese medical science according to " general rule is not bitterly ", provide a kind of based on activating blood circulation to dissipate blood stasis, doublely dispel the wind, cold expelling, dehumidifying, the logical stasis of blood is opened numbness, acute injury, chronic strain, rheumatism class pain is all had the health care spray that is used for the treatment of acute injury, chronic strain, rheumatism class pain of the effect that eases the pain rapidly.Health care spray of the present invention cooperates the endo-medicine treatment can strengthen analgesic effect, improves curative effect, shortens the course of treatment.And have characteristics of " letter ", " just ", " honest and clean ", " testing ".
Purpose of the present invention can realize by following measure:
The acute injury that is used for the treatment of of the present invention, chronic strain, the health care spray of rheumatism class pain is that the feedstock production by the following weight ratio forms, wherein Radix Clematidis 4.5～4.9%, Radix Angelicae Sinensis 4.5～4.9%, Radix Paeoniae Rubra 4.5～4.9%, the Radix Angelicae Dahuricae 6.9～7.3%, Rhizoma Corydalis 9.2～9.6%, Flos Carthami 4.5～4.9%, Radix Angelicae Pubescentis 4.5～4.9, Rhizoma Et Radix Notopterygii 4.5～4.9%, Radix Cyathulae 4.6～5.0%, Camphora 4.6～5.0%, Borneolum Syntheticum 2.3～2.5%, Herba Asari 5.6～5.9%, Lignum Sappan 4.6～5.0%, Caulis Spatholobi 4.6～5.0%, Myrrha 4.6～5.0%, Radix Notoginseng 5.5～5.9%, Fructus Liquidambaris 4.6～5.0%, Fructus Chaenomelis 4.6～5.0%, Rhizoma Homalomenae 4.6～5.0%, Caulis Sinomenii 4.5～4.9%.
The effective ingredient of Radix Clematidis in the prescription is Saponin class and Anemonin, protoanemonin etc. in the present invention, and treatment of arthritis bony spur and sciatica are had certain curative effect; Effective ingredient in the Flos Carthami is a safflower yellow, and the effective ingredient in the Radix Angelicae Sinensis is Radix Angelicae Sinensis oil and ferulic acid etc., and its pharmacological action all has tangible anti-thrombosis function, and the energy anticoagulant; Myrrha contains compositions such as volatile oil, resin, mainly contains eugenol, benzene oil phenol etc. in the volatile oil, has pharmacologically actives such as antimicrobial antiphlogistic and blood circulation promoting and blood stasis dispelling, more than all medicines be monarch drug.The important component of the Radix Angelicae Dahuricae is imperatorin, with furocoumarins such as imperatorin, experimental albumen arthritis and formaldehyde arthritis are had tangible antiinflammatory action; The main component of Lignum Sappan is a haematoxylin etc., has the physiologically active of calmness, analgesia and anticoagulant; The main effective ingredient of Rhizoma Corydalis is multiple alkaloids such as Rhizoma Corydalis first element, tetrahydropalmatine, has calmness, analgesia, anticonvulsant effect; The effective ingredient of Caulis Sinomenii is multiple alkaloids such as sinomenine, has effects such as calmness, analgesia, antiinflammatory, blood pressure lowering, and its ethanol extract has experimental albumen arthritis and formaldehyde arthritis are had tangible antiinflammatory action, more than all medicines be ministerial drug.Caulis Spatholobi contains osajin, flavanone and chalcones etc., has the effect of the hemodynamic of improvement and to immune dual regulation, is adjuvant drug.The main effective ingredient of Fructus Liquidambaris is volatile oil, terpenoid etc., has tangible anti-cell cytotoxic activity; Borneolum Syntheticum, Camphora can strengthen the Transdermal absorption of medicine, and can be used for neuralgia and antiinflammatory, are messenger drug.
Clinical testing data of the present invention is as follows:
One, acute oral toxicity test
A, tried thing---sample is mixed with 250mg/ml with distilled water;
20 of b, experimental animal---Kunming mouses;
C, feedstuff---full nutrition Mus material;
D, test method---mice is divided into two groups by sex, and ten every group, the per os of (freely drinking water) behind the overnight fasting is irritated stomach, and dosage 5000mg/kg irritates stomach amount 0.4ml/20g.After the contamination, continuation fasting 3 hours was also observed 14 days, write down various animal toxic reactions and death toll, judged that according to the chemical substance acute toxicity grading criteria this is tried the toxicity rank of thing.
Two, repeatedly skin irritation test
Four of a, experimental animal---white rabbit, be male, body weight 2kg～3kg.
B, feedstuff---full nutrition rabbit material;
C, test method
24h before the formal experiment uses the elbow shears back part of animal spinal column diamond wool to be cut unhairing scope 3cm * 3cm.
Formal experiment---get and tried thing 0.5ml and spread upon on the skin of unhairing of animal left side (opposite side compares), application area 2.5cm * 2.5cm smears once every day, smears continuously 14 days.Smeared preceding cropping since second day at every turn, and remove the residual thing that tried, observe the animal skin reaction after 1 hour, according to " cosmetics health standard " scoring with clear water.
Three, result
A, acute oral toxicity test
Subordinate list is that health care spray of the present invention is to chmice acute per os toxicity test result
| Sex | Number of animals (only) | Dosage grouping (mg/kg) | Dead animal number (only) | Mortality rate (%) | Irritate the preceding body weight (g) of stomach | One all body weight (g) | Two all body weight (g) | LD 50 (mg/kg) |
| Male female | 10 10 | 5000 5000 | 0 0 | 0 0 | 20.1±1.0 20.1±1.1 | 23.9±3.0 28.4±5.1 | 27.1±1.6 34.2±4.2 | ＞5000 ＞5000 |
Health care spray of the present invention is to male, female chmice acute per os LD
50All greater than 5000mg/kg, judge according to chemical substance acute oral toxicity grade scale: this sample chmice acute per os toxicity belongs to actual nontoxic level.
B, repeatedly skin irritation test
Health care spray of the present invention is to four repeatedly skin irritation reactions of white rabbit, and every day, every animal integral mean value was 00.0.Judge according to " cosmetics health standard " skin irritation strength grading evaluation criterion: this sample is non-stimulated to animal skin.
Health care spray of the present invention cooperates the endo-medicine treatment can strengthen analgesic effect, improves curative effect, shortens the course of treatment.And have characteristics of " letter ", " just ", " honest and clean ", " testing ".
(4) specific embodiment
The present invention does with detailed description below with reference to embodiment:
Embodiment 1:
Present embodiment adopts following proportioning and processing step to realize:
A, get Radix Clematidis 4.7% by weight, Radix Angelicae Sinensis 4.7%, Radix Paeoniae Rubra 4.7%, the Radix Angelicae Dahuricae 7.1%, Rhizoma Corydalis 9.3%, Flos Carthami 4.7%, Radix Angelicae Pubescentis 4.7%, Rhizoma Et Radix Notopterygii 4.6%, Radix Cyathulae 4.8%, Herba Asari 5.6%, Lignum Sappan 4.6%, Caulis Spatholobi 4.6%, Myrrha 4.8%, Radix Notoginseng 5.6%, Fructus Liquidambaris 4.7%, Fructus Chaenomelis 4.7%, Rhizoma Homalomenae 4.6%, Caulis Sinomenii 4.6% 18 flavor medicine is ground into fine powder through pulverizer; Afterwards this coarse powder is joined with the above-mentioned raw materials gross weight and compare for 90-95%, purity are in the ethanol of 80-85%, moistening 4-6h reinstalls in the dark tube and floods 24h, the adverse current percolation; The percolation speed controlling is collected the liquid of just filtering earlier at 1.0ml/kg.min, and its collecting amount is total ethanol weight 51-54%, and container is preserved in addition; The part of being left continues percolation, and the percolation speed controlling regathers the continuous liquid of filtering at 3.0ml/kg.min, liquid merges with just filtering, the twice accumulative total collecting amount promptly first liquid of filtering in front and back is the 94-96% of total ethanol weight with continuing the liquid sum of filtering, and afterwards it is concentrated, and the 80-85% that is concentrated into the percolate gross weight gets final product;
B, get Camphora 4.6% by weight, Borneolum Syntheticum 2.3% is placed on the percolate dissolving, and bottling promptly gets patent medicine behind the mixing.
Embodiment 2:
Present embodiment adopts following proportioning and processing step to realize:
A, get Radix Clematidis 4.7% by weight, Radix Angelicae Sinensis 4.6%, Radix Paeoniae Rubra 4.6%, the Radix Angelicae Dahuricae 7.2%, Rhizoma Corydalis 9.5%, Flos Carthami 4.6%, Radix Angelicae Pubescentis 4.7%, Rhizoma Et Radix Notopterygii 4.7%, Radix Cyathulae 4.7%, Herba Asari 5.6%, Lignum Sappan 4.6%, Caulis Spatholobi 4.6%, Myrrha 4.8%, Radix Notoginseng 5.6%, Fructus Liquidambaris 4.7%, Fructus Chaenomelis 4.7%, Rhizoma Homalomenae 4.6%, Caulis Sinomenii 4.5% 18 flavor medicine is ground into fine powder through pulverizer; Afterwards this coarse powder is joined with the above-mentioned raw materials gross weight and compare for 90-95%, purity are in the ethanol of 80-85%, moistening 4-6h reinstalls in the dark tube and floods 24h, the adverse current percolation; The percolation speed controlling is collected the liquid of just filtering earlier at 1.0ml/kg.min, and its collecting amount is total ethanol weight 51-54%, and container is preserved in addition; The part of being left continues percolation, and the percolation speed controlling regathers the continuous liquid of filtering at 3.0ml/kg.min, liquid merges with just filtering, the twice accumulative total collecting amount promptly first liquid of filtering in front and back is the 94-96% of total ethanol weight with continuing the liquid sum of filtering, and afterwards it is concentrated, and the 80-85% that is concentrated into the percolate gross weight gets final product;
B, get Camphora 4.6% by weight, Borneolum Syntheticum 2.4% is placed on the percolate dissolving, and bottling promptly gets patent medicine behind the mixing.
Claims (1)
1, a kind of acute injury that is used for the treatment of, chronic strain, the health care spray of rheumatism class pain, it is characterized in that: it is that feedstock production by the following weight ratio forms, wherein Radix Clematidis 4.5～4.9%, Radix Angelicae Sinensis 4.5～4.9%, Radix Paeoniae Rubra 4.5～4.9%, the Radix Angelicae Dahuricae 6.9～7.3%, Rhizoma Corydalis 9.2～9.6%, Flos Carthami 4.5～4.9%, Radix Angelicae Pubescentis 4.5～4.9, Rhizoma Et Radix Notopterygii 4.5～4.9%, Radix Cyathulae 4.6～5.0%, Camphora 4.6～5.0%, Borneolum Syntheticum 2.3～2.5%, Herba Asari 5.6～5.9%, Lignum Sappan 4.6～5.0%, Caulis Spatholobi 4.6～5.0%, Myrrha 4.6～5.0%, Radix Notoginseng 5.5～5.9%, Fructus Liquidambaris 4.6～5.0%, Fructus Chaenomelis 4.6～5.0%, Rhizoma Homalomenae 4.6～5.0%, Caulis Sinomenii 4.5～4.9%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410010093 CN1265823C (en) | 2004-02-28 | 2004-02-28 | Health-care spray for treating acute injury, chronic strain, rheumatalgia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410010093 CN1265823C (en) | 2004-02-28 | 2004-02-28 | Health-care spray for treating acute injury, chronic strain, rheumatalgia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1559487A CN1559487A (en) | 2005-01-05 |
| CN1265823C true CN1265823C (en) | 2006-07-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410010093 Expired - Fee Related CN1265823C (en) | 2004-02-28 | 2004-02-28 | Health-care spray for treating acute injury, chronic strain, rheumatalgia |
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| CN (1) | CN1265823C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398127C (en) * | 2006-09-12 | 2008-07-02 | 通化天添安保健品有限公司 | Wind dispelling spray and its prepn process |
| CN101628067B (en) * | 2008-07-20 | 2011-07-20 | 姜玉成 | Medicament for treating diskal hernia and arthralgia |
| CN103007143B (en) * | 2012-12-10 | 2014-06-04 | 韩必芝 | Gaultheria forrestii Diels medicinal liquor and preparation method thereof |
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| CN1559487A (en) | 2005-01-05 |
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Granted publication date: 20060726 |