CN1264517C - 硫酸奈替米星在制备滴眼液制剂中的应用 - Google Patents
硫酸奈替米星在制备滴眼液制剂中的应用 Download PDFInfo
- Publication number
- CN1264517C CN1264517C CN 02138662 CN02138662A CN1264517C CN 1264517 C CN1264517 C CN 1264517C CN 02138662 CN02138662 CN 02138662 CN 02138662 A CN02138662 A CN 02138662A CN 1264517 C CN1264517 C CN 1264517C
- Authority
- CN
- China
- Prior art keywords
- netilmicin sulfate
- eye drop
- netilmicin
- sodium
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
配方编号 | 1 | 2 | 3 | 4 |
硫酸奈替米星(g)亚硫酸氢钠(g)乙二胺四醋酸二钠(g)羟苯乙酯(g)苯甲醇(ml)聚维酮K30(g)β-环糊精(g)磷酸氢二钠(g)磷酸二氢钠(g)醋酸钠(g)硼酸(g)氯化钠(g) | 16.91.00.10.2///0.240.66//0.32 | 16.94//101015//131.4/ | 16.940.1/10105//131.4/ | 16.94/0.2///////0.84 |
颜色 | 微黄 | 浅于黄色2号 | 浅于黄色2号 | 微黄 | |
加速试验1个月 | 澄明度有关物质含量 | 符合规定符合规定无变化 | 有小白块符合规定无变化 | 符合规定符合规定无变化 | 符合规定符合规定无变化 |
组别 | 用药期 | 停药后 | |||||
1d | 2d | 3d | 1d | 3d | 5d | 7d | |
奈替米星大剂量组奈替米星小剂量组阳性对照组角膜损伤+感染组角膜损伤不感染组 | 5.55.54.0254.0 | 4.55.53.5254.0 | 34.03.0252.5 | 022.0231.0 | 011.5221.0 | 001201.0 | 001201.0 |
组别 | 序号 | 用药期 | 停药后 | ||||||||||||
1d | 2d | 3d | 1d | 3d | 5d | 7d | |||||||||
L | R | L | R | L | R | L | R | L | R | L | R | L | R | ||
奈替米星大剂量组 | 12345 | 10.50.50.50.5 | 10.50.500.5 | 10.500.50.5 | 10.5000.5 | 0.5000.50.5 | 10000.5 | 00000 | 00000 | 00000 | 00000 | 00000 | 00000 | 00000 | 00000 |
奈替米星小剂量组阳性对照药组角膜损伤+感染组角膜损伤不 | 1234512345123451234 | 0.50.50.50.50.5010.500.5322320.500.51 | 0.50.50.510.50.51000.5323320.500.50.5 | 0.50.50.50.50.5010.500.5322320.500.51 | 0.50.50.510.501000.5323320.500.50.5 | 00.500.50.501000.5322320.500.50 | 0.50.5010.5010.00.5323320.500.50 | 00.500.5000.5000.5322220000.5 | 00.500.5000.5000.5323220000.5 | 00.500000.5000.5322220000.5 | 00.500000.5000322220000.5 | 0000000.5000322210000.5 | 0000000.5000322210000.5 | 0000000.5000322210000.5 | 0000000.5000322210000.5 |
不感染组 | 5 | 0.5 | 0 | 0.5 | 0 | 0.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 02138662 CN1264517C (zh) | 2002-11-21 | 2002-11-21 | 硫酸奈替米星在制备滴眼液制剂中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 02138662 CN1264517C (zh) | 2002-11-21 | 2002-11-21 | 硫酸奈替米星在制备滴眼液制剂中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1502335A CN1502335A (zh) | 2004-06-09 |
CN1264517C true CN1264517C (zh) | 2006-07-19 |
Family
ID=34231767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 02138662 Expired - Fee Related CN1264517C (zh) | 2002-11-21 | 2002-11-21 | 硫酸奈替米星在制备滴眼液制剂中的应用 |
Country Status (1)
Country | Link |
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CN (1) | CN1264517C (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101805382B (zh) * | 2010-04-14 | 2012-08-08 | 无锡福祈制药有限公司 | 一种高纯度奈替米星的分离纯化方法 |
CN102525963B (zh) * | 2012-02-08 | 2013-05-08 | 武汉普生制药有限公司 | 一种硫酸奈替米星冻干粉针及其制备方法 |
CN105193722B (zh) * | 2015-10-28 | 2021-12-14 | 辅必成(上海)医药科技有限公司 | 二巯丙醇脂肪乳注射液 |
CN105663520B (zh) * | 2016-02-29 | 2019-10-29 | 李宏 | 五虎口服液及其制备方法 |
CN112545985A (zh) * | 2020-12-30 | 2021-03-26 | 卓和药业集团有限公司 | 一种含有硫酸奈替米星的滴眼液及其制备方法 |
CN114275906A (zh) * | 2021-12-10 | 2022-04-05 | 安徽安泰农业开发有限责任公司 | 一种养猪场污水处理复合菌剂及其制备方法 |
-
2002
- 2002-11-21 CN CN 02138662 patent/CN1264517C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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CN1502335A (zh) | 2004-06-09 |
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Owner name: TIANJIN PHARMACEUTICAL GROUP XINZHENG CO., LTD. Free format text: FORMER OWNER: ANHUI AETNA MEDICINE BIOTECHNOLOGY CO., LTD. Effective date: 20100108 |
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Effective date of registration: 20100108 Address after: No. 6, Renmin Middle Road, Xinzheng, Henan Patentee after: Tianjin Pharmaceutical Group Xinzheng Co., Ltd. Address before: Bio pharmaceutical Park, hi tech Zone, 669 West Changjiang Road, Anhui, Hefei Patentee before: Antai Medicine Biotechnology Co., Ltd., Anhui Prov. |
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Tianjin Pharmaceutical Group Xinzheng Co., Ltd. Assignor: Antai Medicine Biotechnology Co., Ltd., Anhui Prov. Contract fulfillment period: 2009.4.15 to 2014.4.14 contract change Contract record no.: 2009410000260 Denomination of invention: Application of Netilmicin sulfate in preparation of eye drops Granted publication date: 20060719 License type: Exclusive license Record date: 20091126 |
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LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.4.15 TO 2014.4.14; CHANGE OF CONTRACT Name of requester: TIANJIN PHARMACEUTICAL GROUP XINZHENG CO., LTD. Effective date: 20091126 |
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EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Tianjin Pharmaceutical Group Xinzheng Co., Ltd. Assignor: Antai Medicine Biotechnology Co., Ltd., Anhui Prov. Contract record no.: 2009410000260 Date of cancellation: 20111219 |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060719 Termination date: 20161121 |
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CF01 | Termination of patent right due to non-payment of annual fee |