CN1263436A - Identification of polynucleotides encoding novel helicobacter polypeptides in helicobacter genome - Google Patents

Identification of polynucleotides encoding novel helicobacter polypeptides in helicobacter genome Download PDF

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CN1263436A
CN1263436A CN98805612A CN98805612A CN1263436A CN 1263436 A CN1263436 A CN 1263436A CN 98805612 A CN98805612 A CN 98805612A CN 98805612 A CN98805612 A CN 98805612A CN 1263436 A CN1263436 A CN 1263436A
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H·克利恩索斯
A·阿尔加拉威
C·米勒
J·－F·图姆
R·P·奥门
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Human Genome Sciences Inc
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Human Genome Sciences Inc
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/121—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Helicobacter (Campylobacter) (G)
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention provides Helicobacter polypeptides that can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides. The invention also provides diagnostic methods employing these polypeptides.

Description

Identification of polynucleotides encoding novel helicobacter polypeptides in the helicobacter genome
The present invention relates to helicobacter antigens and related polynucleotide molecules that can be used in methods of preventing or treating helicobacter infection in mammals such as humans.
Background
Helicobacter is a spirochete, gram-negative bacterium that can colonize the gastrointestinal tract of mammals. Several species colonize the stomach, the most well known being helicobacter pylori (h. pyrori), helicobacter marini (h. heilmanii), helicobacter felis (h.felis) and helicobacter mustelae (h.mustelae). Although H.pylori is the most common species associated with human infection, Helminthobacter marinum and H.felis were also extracted from humans, but the frequency of occurrence was lower than that of H.pylori. Over 50% of the adult population in developed countries is infected with helicobacter, while in developing countries and some countries around the pacific, 100% of the adult population is infected with helicobacter, making it the most prevalent infection worldwide.
Helicobacter is usually recovered from stomach biopsies of people with histological evidence of gastritis and pepticulcers. In fact, helicobacter pylori is now regarded as an important human pathogen, because chronic gastritis caused by it is a risk factor for developing peptic ulcer disease and gastric cancer. Therefore, there is an urgent need to develop safe and effective vaccines for the prevention and treatment of helicobacter infection.
A variety of helicobacter antigens have been identified or extracted. Including urease, which includes two structural subunits of approximately 30 and 67kDa (Hu et al, immunology of infection 58: 992, 1990; Dunn et al, biochemistry 265: 9464, 1990; Evans et al, microbiology 10: 15, 1991; Labigne et al, journal of bacteriology 173: 1920, 1991); and 87kDa vacuolar cytotoxin (VacA) (Cover et al, J. biol. chem. 267: 10570, 1992; Phadnis et al, Immunol. 62: 1557, 1994; WO 93/18150); the 128kD immunodominant antigen associated with cytotoxins (CagA, also known as TagA; WO 93/18150; US Patent No 5,403,924); 13 and 58kDa heat shock proteins HspA and HspB (Suerbaum et al, molecular microbiology 14: 959, 1994; WO 93/18150); a 54kDa catalase (Hazell et al, J. Gen. microbiology 137: 57, 1991); 15kDa histidine-rich protein (Hpn) (Gilbert et al, infection immunology 63: 2682, 1995); 20kDa membrane-associated lipoprotein (Kostrcynska et al, J. Bacteriol 176: 5938, 1994); an outer membrane protein of 30kDa (Bolin et al, J.Clin. Microbiol. 33: 381, 1995); lactoferrin receptors (FR2, 724, 936); and several porins, designated HopA, HopB, HopC, HopD and HopE, with molecular weights of 48-67kDa (Exner et al, infection immunology 63: 1567, 1995; Doig et al, J. Bacteriol 177: 5447, 1995). Some of these proteins have been proposed as potential vaccine antigens. In particular, urease is considered a vaccine candidate (WO 94/9823; WO 95/22987; WO 95/3824; Michetti et al, gastroenterology 107: 1002, 1994). However, it is thought that several antigens are ultimately required in one vaccine.
Summary of the invention
The present invention provides polynucleotide molecules encoding helicobacter polypeptides, designated
GHPO 35(SEQ ID NO: 2), GHPO 55(SEQ ID NO: 4), GHPO78 (SEQ ID NO: 6), GHPO89 (SEQ ID NO: 8), GHPO129(SEQ ID NO: 10), GHPO 541(SEQ ID NO: 12), GHPO 607(SEQ ID NO: 14), GHPO 635(SEQ ID NO: 16), GHPO 701(SEQ ID NO: 18), GHPO712(SEQ ID NO: 20), GHPO761(SEQ ID NO: 22), GHPO 838(SEQ ID NO: 24), GHPO 1034(SEQ ID NO: 26), GHPO 1085(SEQ ID NO: 28), GHPO1213(SEQ ID NO: 30), GHPO1255(SEQ ID NO: 32), GHPO 1308(SEQ ID NO: 34), GHPO 1381034 (SEQ ID NO: 36), GHPO 1706(SEQ ID NO: 38), GHPO234(SEQ ID NO: 40), GHPO314(SEQ ID NO: 42), GHPO 510(SEQ ID NO: 44), GHPO 603(SEQ ID NO: 46), GHPO 937(SEQ ID NO: 48), GHPO1027(SEQ ID NO: 50), GHPO1099(SEQ ID NO: 52), GHPO 1151(SEQ ID NO: 54), GHPO 1275(SEQ ID NO: 56), GHPO 1365(SEQ ID NO: 58), GHPO1578(SEQ ID NO: 60), GHPO22(SEQ ID NO: 62), GHPO58 (SEQ ID NO: 64), GHPO 200(SEQ ID NO: 66), GHPO 558(SEQ ID NO: 68), GHPO563(SEQ ID NO: 70), GHPO 695(SEQ ID NO: 72), GHPO 699(SEQ ID NO: 74), GHPO 702(SEQ ID NO: 76), GHPO709(SEQ ID NO: 78), GHPO741(SEQ ID NO: 80), GHPO 762(SEQ ID NO: 82), GHPO 852(SEQ ID NO: 827), GHPO 84), GHPO86(SEQ ID NO: 86), GHPO1013(SEQ ID NO: 88), GHPO1020(SEQ ID NO: 90), GHPO 1031(SEQ ID NO: 92), GHPO 1052(SEQ ID NO: 94), GHPO 1127(SEQ ID NO: 96), GHPO1149(SEQ ID NO: 98), GHPO1176(SEQ ID NO: 100), GHPO 1250(SQ ID NO: 102), GHPO 1312(SEQ ID NO: 104), GHPO 1358(SEQ ID NO: 106), GHPO 1490(SEQ ID NO: 108), GHPO 1559(SEQ ID NO: 110), GHPO 1651(SEQ ID NO: 112), GHPO 1726(SEQ ID NO: 114), GHPO 1780(SEQ ID NO: 116), GHPO 895(SEQ ID NO: 118), GHPO 1447(SEQ ID NO: 120), GHPO28 (SEQ ID NO: 122), GHPO86(SEQ ID NO: 124),GHPO 155(SEQ ID NO: 126), GHPO 157), GHPO 237(SEQ ID NO: 130), GHPO 290(SEQ ID NO: 132), GHPO293(SEQ ID NO: 134), GHPO 335(SEQ ID NO: 136), GHPO 374(SEQ ID NO: 138), GHPO 442(SEQ ID NO: 140), GHPO 480(SEQ ID NO: 142), GHPO523(SEQ ID NO: 144), GHPO610(SEQ ID NO: 146), GHPO 675(SEQ ID NO: 148), GHPO 690(SEQ ID NO: 150), GHPO 829(SEQ ID NO: 152), GHPO850(SEQ ID NO: 154), GHPO876(SEQ ID NO: 156), GHPO 984(SEQ ID NO: 158), GHPO 989(SEQ ID NO: 160), GHPO 1111(SEQ ID NO: 162), GHPO 1145(SEQ ID NO: 164), GHPO 1256(SEQ ID NO: 166), GHPO 1264(SEQ ID NO: 168), GHPO 1316(SEQ ID NO: 170), GHPO 1368(SEQ ID NO: 172), GHPO 1442(SEQ ID NO: 174), GHPO 1506(SEQ ID NO: 176), GHPO 1543(SEQ ID NO: 178), GHPO 1574(SEQ ID NO: 180), GHPO 1627(SEQ ID NO: 182), GHPO 1657(SEQ ID NO: 184), GHPO 1664(SEQ ID NO: 186), GHPO 1694(SEQ ID NO: 188), GHPO 1704(SEQ ID NO: 190), GHPO 1763(SEQ ID NO: 192), GHPO 616(SEQ ID NO: 194), GHPO76 (SEQ ID NO: 196), GHPO109 (SEQ ID NO: 198), GHPO163 (SEQ ID NO: 200), GHPO 169(SEQ ID NO: 202), GHPO 208(SEQ ID NO: 204), GHPO219(SEQ ID NO: 206), GHPO (SEQ ID NO: 445), GHPO 208(SEQ ID NO: 479(SEQ ID NO: 210), GHPO (SEQ ID NO: 212), GHPO 535(SEQ ID NO: 214), GHPO731(SEQ ID NO: 216), GHPO836(SEQ ID NO: 218), GHPO 879(SEQ ID NO: 220), GHPO 881(SEQ ID NO: 222), GHPO 886(SEQ ID NO: 224), GHPO893(SEQ ID NO: 226), GHPO894(SEQ ID NO: 228), GHPO 976(SEQ ID NO: 230), GHPO 1011(SEQ ID NO: 232), GHPO 1024(SEQ ID NO: 234), GHPO 1084(SEQ ID NO: 236), GHPO 1329(SEQ ID NO: 238), GHPO 1330(SEQ ID NO: 240), GHPO 1346(SEQ ID NO: 242), GHPO 1360(SEQ ID NO: 244), GHPO 1388(SEQ ID NO: 246), GHPO 1411(SEQ ID NO: 248), GHPO 9(SEQ ID NO: 250), GHPO 1446(SEQ ID NO: 144252), GHPO 254 (SEQ ID NO: 1469), GHPO 1501(SEQ ID NO: 256), GHPO 1505(SEQ ID NO: 258), GHPO 1522(SEQ ID NO: 260), GHPO 1525(SEQ ID NO: 262), GHPO 1615(SEQ ID NO: 264), GHPO 1689(SEQ ID NO: 266), GHPO 1733(SEQ ID NO: 268), GHPO18 (SEQ ID NO: 270), GHPO 139(SEQ ID NO: 272), GHPO142 (SEQ ID NO: 274), GHPO 250(SEQ ID NO: 276), GHPO257(SEQ ID NO: 278), GHPO325(SEQ ID NO: 280), GHPO355(SEQ ID NO: 282), GHPO 357(SEQ ID NO: 284), GHPO 454(SEQ ID NO: 286), GHPO (SEQ ID NO: 288), GHPO515(SEQ ID NO: 290), GHPO 527(SEQ ID NO: 527), GHPO 551(SEQ ID NO: 294), GHPO 602(SEQ ID NO: 296), GHPO626(SEQ ID NO: 298), GHPO646(SEQ ID NO: 300), GHPO 653(SEQ ID NO: 302), GHPO 655(SEQ ID NO: 304), GHPO 670(SEQ ID NO: 306), GHPO739(SEQ ID NO: 308), GHPO798(SEQ ID NO: 310), GHPO 1102(SEQ ID NO: 312), GHPO 1114(SEQ ID NO: 314), GHPO 1152(SEQ ID NO: 316), GHPO 1272(SEQ ID NO: 318), GHPO 1345(SEQ ID NO: 320), GHPO 1377(SEQ ID NO: 322), GHPO 1424(SEQ ID NO: 324), GHPO 1430(SEQ ID NO: 326), GHPO 1502(SEQ ID NO: 328), GHPO 1600(SEQ ID NO: 330), GHPO 1714(SEQ ID NO: 332), GHPO 359(SEQ ID NO: 334), GHPO 678(SEQ ID NO: 336), GHPO 338), GHPO 759(SEQ ID NO: 340), GHPO 847(SEQ ID NO: 342), GHPO 1050(SEQ ID NO: 344), GHPO 1101(SEQ ID NO: 346), GHPO 1120(SEQ ID NO: 348), GHPO 1138(SEQ ID NO: 350), GHPO 1310(SEQ ID NO: 352), GHPO 1320(SEQ ID NO: 354), GHPO 1375(SEQ ID NO: 356), GHPO 1432(SEQ ID NO: 358), GHPO21 (SEQ ID NO: 360), GHPO282(SEQ ID NO: 362), GHPO 1089(SEQ ID NO: 364), GHPO 1141(SEQ ID NO: 366), GHPO 1280(SEQ ID NO: 368), GHPO 1608(SEQ ID NO: 370), GHPO15 (SEQ ID NO: 372), GHPO16(SEQ ID NO: 374), GHPO36 (SEQ ID NO: 376), GHPO38 (SEQ ID NO: 378), GHPO52 (SEQ ID NO: 380), GHPO57(SEQ ID NO: 382), GHPO64(SEQ ID NO: 384), GHPO79 (SEQ ID NO: 386), GHPO84 (SEQ ID NO: 388), GHPO86(SEQ ID NO: 390), GHPO99(SEQ ID NO: 392), GHPO106(SEQ ID NO: 394), GHPO 118(SEQ ID NO: 396), GHPO 122(SEQ ID NO: 398), GHPO128 (SEQ ID NO: 400), GHPO138(SEQ ID NO: 402), GHPO153(SEQ ID NO: 404), GHPO 160(SEQ ID NO: 406), GHPO 168(SEQ ID NO: 408), GHPO 179(SEQ ID NO: 410), GHPO189(SEQ ID NO: 412), GHPO229(SEQ ID NO: 414), GHPO 243(SEQ ID NO: 416), GHPO 244(SEQ ID NO: 418), GHPO 251(SEQ ID NO: 420), GHPO267(SEQ ID NO: 422), GHPO269(SEQ ID NO: 424), GHPO 279(SEQ ID NO: 426), GHPO 284(SEQ ID NO: 428), GHPO296 (SEQ ID NO: 430), GHPO300(SEQ ID NO: 432), GHPO305(SEQ ID NO: 434), GHPO 319(SEQ ID NO: 436), GHPO 330(SEQ ID NO: 438), GHPO 340(SEQ ID NO: 440),GHPO342(SEQ ID NO: 442), GHPO344(SEQ ID NO: 444), GHPO 358(SEQ ID NO: 446), GHPO 373(SEQ ID NO: 448), GHPO 382(SEQ ID NO: 450), GHPO384(SEQ ID NO: 452), GHPO398(SEQ ID NO: 454), GHPO (SEQ ID NO: 456), GHPO 422(SEQ ID NO: 458), GHPO 430(SEQ ID NO: 460), GHPO446(SEQ ID NO: 462), GHPO (SEQ ID NO: 464), GHPO 450(SEQ ID NO: 466), GHPO 451(SEQ ID NO: 468), GHPO 452(SEQ ID NO: 470), GHPO456(SEQ ID NO: 472), GHPO461(SEQ ID NO: 474), GHPO 476(SEQ ID NO: 476), GHPO 478(SEQ ID NO: 478), GHPO 491(SEQ ID NO: 480), GHPO511(SEQ ID NO: 482), GHPO519(SEQ ID NO: 484), GHPO 526(SEQ ID NO: 486), GHPO 534(SEQ ID NO: 488), GHPO 536(SEQ ID NO: 490), GHPO542(SEQ ID NO: 492), GHPO544(SEQ ID NO: 494), GHPO (SEQ ID NO: 496), GHPO 578(SEQ ID NO: 488), GHPO 580(SEQ ID NO: 500), GHPO585(SEQ ID NO: 502), GHPO599(SEQ ID NO: 504), GHPO 639(SEQ ID NO: 506), GHPO 642(SEQ ID NO: 508), GHPO 498(SEQ ID NO: 576), GHPO654(SEQ ID NO: 512), GHPO669(SEQ ID NO: 514), GHPO 710(SEQ ID NO: 516), GHPO 713(SEQ ID NO: 518), GHPO 716(SEQ ID NO: 520), GHPO718(SEQ ID NO: 522), GHPO726(SEQ ID NO: 524), GHPO 734(SEQ ID NO: 526), GHPO 740(SEQ ID NO: 528), GHPO 770(SEQ ID NO: 530), GHPO782(SEQ ID NO: 532), GHPO786(SEQ ID NO: 534), GHPO 792(SEQ ID NO: 536), GHPO 797(SEQ ID NO: 538), GHPO 816(SEQ ID NO: 540), GHPO (SEQ ID NO: 542), GHPO839(SEQ ID NO: 544), GHPO840 (SEQ ID NO: 546), GHPO 842(SEQ ID NO: 548), GHPO 885(SEQ ID NO: 550), GHPO889(SEQ ID NO: 552 NO: 889), GHPO903(SEQ ID NO: 554), GHPO 912(SEQ ID NO: 556), GHPO 946(SEQ ID NO: 558), GHPO 958(SEQ ID NO: 560), GHPO968(SEQ ID NO: 562), GHPO987(SEQ ID NO: 564), GHPO 992 SEQ ID NO: 566) GHPO 996(SEQ id no: 568) GHPO 997(SEQ ID NO: 570) GHPO1002(SEQ ID NO: 572) GHPO 1026(SEQ ID NO: 574) GHPO 1028(SEQ ID NO: 576) GHPO 1034(SEQ ID NO: 578) GHPO 1038(SEQ ID NO: 580) GHPO 1059(SEQ id no: 582) GHPO 1065(SEQ ID NO: 584) GHPO 1072(SEQ ID NO: 586) GHPO 1073(SEQ ID NO: 588) GHPO 1088(SEQ ID NO: 590) GHPO 1091(SEQ ID NO: 592) GHPO 1105(SEQ ID NO: 594) GHPO 1115(SEQ id no: 596) GHPO 1159(SEQ ID NO: 598) GHPO 1177(SEQ ID NO: 600)GHPO 1187(SEQ ID NO: 602) GHPO 1192(SEQ ID NO: 604) GHPO 1195(SEQ ID NO: 606) GHPO 1224(SEQ ID NO: 608) GHPO 1225(SEQ id no: 610) GHPO 1228(SEQ ID NO: 612) GHPO 1229(SEQ ID NO: 614) GHPO 1231(SEQ ID NO: 616) GHPO 1236(SEQ ID NO: 618) GHPO 1242(SEQ ID NO: 620) GHPO 1248(SEQ ID NO: 622) GHPO 1270(SEQ id no: 624) GHPO 1271(SEQ ID NO: 626) GHPO 1298(SEQ ID NO: 628) GHPO 1301(SEQ ID NO: 630) GHPO 1304(SEQ ID NO: 632) GHPO 1315(SEQ ID NO: 634) GHPO 1319(SEQ ID NO: 636) GHPO 1323(SEQ id no: 638) GHPO 1331(SEQ ID NO: 640) GHPO 1332(SEQ ID NO: 642) GHPO 1347(SEQ ID NO: 644) GHPO 1373(SEQ ID NO: 646) GHPO 1376(SEQ ID NO: 648) GHPO 1380(SEQ ID NO: 650) GHPO 1394(SEQ id no: 652) GHPO 1407(SEQ ID NO: 654) GHPO 1415(SEQ ID NO: 656) GHPO 1425(SEQ ID NO: 658) GHPO 1427(SEQ ID NO: 660) GHPO 1444(SEQ ID NO: 662) GHPO 1449(SEQ ID NO: 664) GHPO 1465(SEQ id no: 666) GHPO 1475(SEQ ID NO: 668) GHPO 1479(SEQ ID NO: 670) GHPO 1483(SEQ ID NO: 672) GHPO 1488(SEQ ID NO: 674) GHPO 1496(SEQ ID NO: 676) GHPO 1524(SEQ ID NO: 678) GHPO 1536(SEQ id no: 680) GHPO 1539(SEQ ID NO: 682) GHPO 1540(SEQ ID NO: 684) GHPO 1542(SEQ ID NO: 686) GHPO 1555(SEQ ID NO: 688) GHPO 1560(SEQ ID NO: 690) GHPO 1564(SEQ ID NO: 692) GHPO 1570(SEQ id no: 694) GHPO 1588(SEQ ID NO: 696) GHPO 1604(SEQ ID NO: 698) GHPO 1605(SEQ ID NO: 700) GHPO 1619(SEQ ID NO: 702) GHPO 1629(SEQ ID NO: 704) GHPO 1642(SEQ ID NO: 706) GHPO 1654(SEQ id no: 708) GHPO 1661(SEQ ID NO: 710) GHPO 1673(SEQ ID NO: 712) GHPO 1687(SEQ ID NO: 714) GHPO 1692(SEQ ID NO: 716) GHPO 1693(SEQ ID NO: 718) GHPO 1699(SEQ ID NO: 720) GHPO 1738(SEQ id no: 722) GHPO 1745(SEQ ID NO: 724) GHPO 1746(SEQ ID NO: 726) GHPO 1754(SEQ ID NO: 728) GHPO 1792(SEQ ID NO: 730) GHPO 1795(SEQ ID NO: 732) GHPO 1796(SEQ ID NO: 734) GHPO 7(SEQ id no: 736) GHPO 8(SEQ ID NO: 738) GHPO 9(SEQ ID NO: 740) GHPO10 (SEQ ID NO: 742) GHPO12 (SEQ ID NO: 744) GHPO25(SEQ ID NO: 746) GHPO27 (SEQ ID NO: 748) GHPO29 (SEQ ID NO: 750) GHPO30 (SEQ id no: 752) GHPO 37(SEQ ID NO: 754) GHPO49(SEQ ID NO: 756) GHPO51(SEQ ID NO: 758) GHPO54 (SEQ ID NO: 760)GHPO65 (SEQ id no: 762) GHPO66 (SEQ ID NO: 764) GHPO68(SEQ ID NO: 766) GHPO70(SEQ ID NO: 768) GHPO 77(SEQ ID NO: 770) GHPO83 (SEQ id no: 772) GHPO85 (SEQ ID NO: 774) GHPO87(SEQ ID NO: 776) GHPO91(SEQ ID NO: 778) GHPO 92(SEQ ID NO: 780) GHPO96 (SEQ id no: 782) GHPO 97(SEQ ID NO: 784) GHPO111(SEQ ID NO: 786) GHPO115(SEQ ID NO: 788) GHPO117 (SEQ ID NO: 790) GHPO 123(SEQ id no: 792) GHPO 124(SEQ ID NO: 794) GHPO126(SEQ ID NO: 796) GHPO127(SEQ ID NO: 798) GHPO128 (SEQ ID NO: 800) GHPO 131(SEQ id no: 802) GHPO 133(SEQ ID NO: 804) GHPO140(SEQ ID NO: 806) GHPO141(SEQ ID NO: 808) GHPO 145(SEQ ID NO: 810) GHPO147 (SEQ id no: 812) GHPO 166(SEQ ID NO: 814) GHPO181(SEQ ID NO: 816) GHPO187(SE Q ID NO: 818) GHPO 188(SEQ ID NO: 820) GHPO 192(SEQ id no: 822) GHPO 202(SEQ ID NO: 824) GHPO204(SEQ ID NO: 826) GHPO205(SEQ ID NO: 828) GHPO 212(SEQ ID NO: 830) GHPO 218(SEQ id no: 832) GHPO 226(SEQ ID NO: 834) GHPO231(SEQ ID NO: 836) GHPO236(SEQ ID NO: 838) GHPO 239(SEQ ID NO: 840) GHPO 245(SEQ id no: 842) GHPO 246(SEQ ID NO: 844) GHPO248(SEQ ID NO: 846) GHPO253(SEQ ID NO: 848) GHPO 265(SEQ ID NO: 850) GHPO 266(SEQ id no: 852) GHPO 271(SEQ ID NO: 854) GHPO272(SEQ ID NO: 856) GHPO286(SEQ ID NO: 858) GHPO 291(SEQ ID NO: 860) GHPO 292(SEQ id no: 862) GHPO 297(SEQ ID NO: 864) GHPO304(SEQ ID NO: 866) GHPO307(SEQ ID NO: 868) GHPO 324(SEQ ID NO: 870) GHPO 326(SEQ id no: 872) GHPO 331(SEQ ID NO: 874) GHPO343(SEQ ID NO: 876) GHPO345(SEQ ID NO: 878) GHPO 346(SEQ ID NO: 880) GHPO 352(SEQ id no: 882) GHPO 355(SEQ ID NO: 884) GHPO363(SEQ ID NO: 886) GHPO369(SEQ ID NO: 888) GHPO 376(SEQ ID NO: 890) GHPO 378(SEQ id no: 892) GHPO 388(SEQ ID NO: 894) GHPO396(SEQ ID NO: 896) GHPO403(SEQ ID NO: 898) GHPO 410(SEQ ID NO: 900) GHPO 415(SEQ id no: 902) GHPO 421(SEQ ID NO: 904) GHPO439(SEQ ID NO: 906) GHPO441(SEQ ID NO: 908) GHPO 443(SEQ ID NO: 910) GHPO 453(SEQ id no: 912) GHPO 455(SEQ ID NO: 914) GHPO464(SEQ ID NO: 916) GHPO467(SEQ ID NO: 918) GHPO 468(SEQ ID NO: 920) GHPO 470(SEQ id no: 922) GHPO 486(SEQ ID NO: 924) GHPO487(SEQ ID NO: 926) GHPO488(SEQ ID NO: 928) GHPO 489(SEQ ID NO: 930) GHPO 498(SEQ id no: 932) GHPO 501(SEQ ID NO: 934) GHPO504(SEQ ID NO: 936) GHPO512(SEQ ID NO: 938) GHPO 517(SEQ ID NO: 940) GHPO 520(SEQ id no: 942) GHPO 528(SEQ ID NO: 944) GHPO530(SEQ ID NO: 946) GHPO532(SEQ ID NO: 948) GHPO 548(SEQ ID NO: 950) GHPO 561(SEQ id no: 952) GHPO 564(SEQ ID NO: 954) GHPO572(SEQ ID NO: 956) GHPO573(SEQ ID NO: 958) GHPO 574(SEQ ID NO: 960) GHPO 577(SEQ id no: 962) GHPO 579(SEQ ID NO: 964) GHPO583(SEQ ID NO: 966) GHPO588(SEQ ID NO: 968) GHPO 593(SEQ ID NO: 970) GHPO 597(SEQ id no: 972) GHPO 598(SEQ ID NO: 974) GHPO604(SEQ ID NO: 976) GHPO606(SEQ ID NO: 978) GHPO 611(SEQ ID NO: 980) GHPO 612(SEQ id no: 982) GHPO615 (SEQ ID NO: 984) GHPO632(SEQ ID NO: 986) GHPO633(SEQ ID NO: 988) GHPO 637(SEQ ID NO: 990) GHPO 651(SEQ id no: 992) GHPO 663(SEQ ID NO: 994) GHPO686(SEQ ID NO: 996) GHPO693(SEQ ID NO: 998) GHPO 698(SEQ ID NO: 1000) GHPO 703(SEQ id no: 1002) GHPO 704(SEQ ID NO: 1004) GHPO 705(SEQ ID NO: 1006) GHPO 707(SEQ ID NO: 1008) GHPO 721(SEQ ID NO: 1010) GHPO 727(SEQ ID NO: 1012) GHPO 728(SEQ ID NO: 1014) GHPO 733(SEQ id no: 1016) GHPO 758(SEQ ID NO: 1018) GHPO 763(SEQ ID NO: 1020) GHPO 771(SEQ ID NO: 1022) GHPO 774(SEQ ID NO: 1024) GHPO 776(SEQ ID NO: 1026) GHPO 783(SEQ ID NO: 1028) GHPO 800(SEQ id no: 1030) GHPO 806(SEQ ID NO: 1032) GHPO 807(SEQ ID NO: 1034) GHPO 808(SEQ ID NO: 1036) GHPO 809(SEQ ID NO: 1038) GHPO 811(SEQ ID NO: 1040) GHPO 815(SEQ ID NO: 1042) GHPO 819(SEQ id no: 1044) GHPO 841(SEQ ID NO: 1046) GHPO 843(SEQ ID NO: 1048) GHPO 846(SEQ ID NO: 1050) GHPO 875(SEQ ID NO: 1052) GHPO 892(SEQ ID NO: 1054) GHPO 902(SEQ ID NO: 1056) GHPO 904(SEQ id no: 1058) GHPO 906(SEQ ID NO: 1060) GHPO 908(SEQ ID NO: 1062) GHPO 921(SEQ ID NO: 1064) GHPO 923(SEQ ID NO: 1066) GHPO 926(SEQ ID NO: 1068) GHPO 933(SEQ ID NO: 1070) GHPO 939(SEQ id no: 1072) GHPO 940(SEQ ID NO: 1074) GHPO 943(SEQ ID NO: 1076) GHPO 951(SEQ ID NO: 1078) GHPO961 (SEQ ID NO: 1080) GHPO 965(SEQ ID NO: 1082) GHPO 990(SEQ ID NO: 1084) GHPO 991(SEQ id no: 1086) GHPO 998(SEQ ID NO: 1088) GHPO 1001(SEQ ID NO: 1090) GHPO 1005(SEQ ID NO: 1092) GHPO1033(SEQ ID NO: 1094) GHPO1039 (SEQ ID NO: 1096) GHPO 1041(SEQ ID NO: 1098) GHPO 1043(SEQID NO: 1100) GHPO 1044(SEQ ID NO: 1102) GHPO 1051(SEQ id no: 1104) GHPO 1058(SEQ ID NO: 1106) GHPO 1060(SEQ ID NO: 1108) GHPO 1075(SEQ ID NO: 1110) GHPO1077(SEQ ID NO: 1112) GHPO1082(SEQ ID NO: 1114) GHPO 1083(SEQ ID NO: 1116) GHPO 1086(seq id NO: 1118) GHPO 1087(SEQ ID NO: 1120) GHPO 1090(SEQ id no: 1122) GHPO 1097(SEQ ID NO: 1124) GHPO 1098(SEQ ID NO: 1126) GHPO 1103(SEQ ID NO: 1128) GHPO1113(SEQ ID NO: 1130) GHPO1116 (SEQ ID NO: 1132) GHPO 1123(SEQ ID NO: 1134) GHPO 1125(seq id NO: 1136) GHPO 1129(SEQ ID NO: 1138) GHPO 1130(SEQ id no: 1140) GHPO 1134(SEQ ID NO: 1142) GHPO 1161(SEQ ID NO: 1144) GHPO 1166(SEQ ID NO: 1146) GHPO1170(SEQ ID NO: 1148) GHPO1175(SEQ ID NO: 1150) GHPO 1181(SEQ ID NO: 1152) GHPO 1186(SEQID NO: 1154) GHPO 1188(SEQ ID NO: 1156) GHPO 1191(SEQ id no: 1158) GHPO 1193(SEQ ID NO: 1160) GHPO 1196(SEQ ID NO: 1162) GHPO 1204(SEQ ID NO: 1164) GHPO1210(SEQ ID NO: 1166) GHPO1211(SEQ ID NO: 1168) GHPO 1216(SEQ ID NO: 1170) GHPO 1218(seq id NO: 1172) GHPO 1220(SEQ ID NO: 1174) GHPO 1223(SEQ id no: 1176) GHPO 1226(SEQ ID NO: 1178) GHPO 1240(SEQ ID NO: 1180) GHPO 1246(SEQ ID NO: 1182) GHPO1251(SEQ ID NO: 1184) GHPO1252(SEQ ID NO: 1186) GHPO 1261(SEQ ID NO: 1188) GHPO 1265(seq id NO: 1190) GHPO 1267(SEQ ID NO: 1192) GHPO 1278(SEQ id no: 1194) GHPO1282 (SEQ ID NO: 1196) GHPO 1283(SEQ ID NO: 1198) GHPO 1287(SEQ ID NO: 1200) GHPO1292(SEQ ID NO: 1202) GHPO1293(SEQ ID NO: 1204) GHPO 1302(SEQ ID NO: 1206) GHPO 1309(seq id NO: 1208) GHPO 1317(SEQ ID NO: 1210) GHPO 1318(SEQ id no: 1212) GHPO 1321(SEQ ID NO: 1214) GHPO 1325(SEQ ID NO: 1216) GHPO 1341(SEQ ID NO: 1218) GHPO1351(SEQ ID NO: 1220) GHPO1354(SEQ ID NO: 1222) GHPO 1363(SEQ ID NO: 1224) GHPO 1371(SEQID NO: 1226) GHPO 1381(SEQ ID NO: 1228) GHPO 1401(SEQ id no: 1230) GHPO 1402(SEQ ID NO: 1232) GHPO 1403(SEQ ID NO: 1234) GHPO 1408(SEQ ID NO: 1236) GHPO1416(SEQ ID NO: 1238) GHPO1420(SEQ ID NO: 1240) GHPO 1428(SEQ ID NO: 1242) GHPO 1437(seq id NO: 1244) GHPO 1439(SEQ ID NO: 1246) GHPO 1460(SEQ id no: 1248) GHPO 1463(SEQ ID NO: 1250) GHPO 1472(SEQ ID NO: 1252) GHPO 1474(SEQ ID NO: 1254) GHPO1484(SEQ ID NO: 1256) GHPO1489(SEQ ID NO: 1258) GHPO 1494(SEQ ID NO: 1260) GHPO 1495(seq id NO: 1262) GHPO 1498(SEQ ID NO: 1264) GHPO 1499(SEQ id no: 1266) GHPO 1500(SEQ ID NO: 1268) GHPO 1503(SEQ ID NO: 1270) GHPO 1504(SEQ ID NO: 1272) GHPO1510(SEQ ID NO: 1274) GHPO1518(SEQ ID NO: 1276) GHPO 1533(SEQ ID NO: 1278) GHPO 1541(seq id NO: 1280) GHPO 1544(SEQ ID NO: 1282) GHPO 1548(SEQ id no: 1284) GHPO 1565(SEQ ID NO: 1286) GHPO 1575(SEQ ID NO: 1288) GHPO 1582(SEQ ID NO: 1290) GHPO1595(SEQ ID NO: 1292) GHPO1597(SEQ ID NO: 1294) GHPO 1599(SEQ ID NO: 1296) GHPO 1601(SEQID NO: 1298) GHPO 1609(SEQ ID NO: 1300) GHPO 1613(SEQ id no: 1302) GHPO 1614(SEQ ID NO: 1304) GHPO 1626(SEQ ID NO: 1306) GHPO 1628(SEQ ID NO: 1308) GHPO1639(SEQ ID NO: 1310) GHPO1640(SEQ ID NO: 1312) GHPO 1641(SEQ ID NO: 1314) GHPO 1646(seq id NO: 1316) GHPO 1662(SEQ ID NO: 1318) GHPO 1667(SEQ id no: 1320) GHPO 1668(SEQ ID NO: 1322) GHPO 1670(SEQ ID NO: 1324) GHPO 1671(SEQ ID NO: 1326) GHPO1672(SEQ ID NO: 1328) GHPO1678 (SEQ ID NO: 1330) GHPO 1684(SEQ ID NO: 1332) GHPO 1695(SEQID NO: 1334) GHPO 1697(SEQ ID NO: 1336) GHPO 1701(SEQ id no: 1338) GHPO1719(SEQ ID NO: 1340) GHPO 1723(SEQ ID NO: 1342) GHPO 1732(SEQ ID NO: 1344) GHPO1739(SEQ ID NO: 1346) GHPO1741(SEQ ID NO: 1348) GHPO 1747(SEQ ID NO: 1350) GHPO 1749(seq id NO: 1352) GHPO 1750(SEQ ID NO: 1354) GHPO 1751(SEQ id no: 1356) GHPO 1755(SEQ ID NO: 1358) GHPO 1771(SEQ ID NO: 1360) GHPO 1786(SEQ ID NO: 1362) and GHPO1789(SEQ ID NO: 1364) the polypeptides may be used in methods such as the prevention, treatment or diagnosis of helicobacter infection. The sequences of the polynucleotides encoding these polypeptides are shown in the sequence listing (odd numbered up to sequence 1363). It will be appreciated by those skilled in the art that the invention also includes polynucleotide molecules encoding mutants and derivatives of the polypeptides which are produced by the addition, deletion, or substitution of non-essential amino acids, as will be further described below.
In addition to the polynucleotide molecules described above, the present invention includes the corresponding polypeptides (i.e., the polypeptides encoded by the polynucleotide molecules of the present invention or fragments thereof), as well as monospecific antibodies capable of specifically binding the polypeptides. The polypeptides of the invention include polypeptides having the amino acid sequence shown in the sequence listing (even numbers, up to sequence 1363), as well as mature forms of the protein having the sequence shown in its unprocessed form in the sequence listing, and fragments thereof.
The invention has a variety of uses, including expression cassettes, vectors, and cells transformed or transfected with the polypeptides of the invention. Accordingly, the present invention provides (i) methods for producing the polypeptides of the invention in recombinant host systems, as well as related expression cassettes, vectors, and transformed or transfected cells; (ii) live vaccine vectors such as poxvirus, Salmonella typhimurium, and Vibrio cholerae (Vibrio cholerae) vectors comprising a polypeptide of the present invention in combination with a diluent or carrier (which may be used in methods such as the prevention or treatment of helicobacter infection), as well as related pharmaceutical compositions and related therapeutic and/or prophylactic methods; (iii) therapeutic and/or prophylactic methods involving the administration of polynucleotide molecules in naked form or in compatible with delivery vehicles, polypeptides or mixtures of polypeptides, or monospecific antibodies of the invention, as well as related pharmaceutical compositions; (iv) a method for detecting the presence of helicobacter in a biological sample, which method may comprise the use of a polynucleotide molecule, monospecific antibody, or polypeptide of the invention; and (v) a method for purifying the polypeptide of the present invention by antibody-based affinity chromatography.
Detailed Description
Open Reading Frames (ORFs) encoding novel polypeptides have been identified in the H.pylori genome, these polypeptides being designated GHPO 35(SEQ ID NO: 2), GHPO 55(SEQ ID NO: 4), GHPO78 (SEQ ID NO: 6), GHPO89 (SEQ ID NO: 8), GHPO129(SEQ ID NO: 10), GHPO 541(SEQ ID NO: 12), GHPO 607(SEQ ID NO: 14), GHPO 635(SEQ ID NO: 16), GHPO 701(SEQ ID NO: 18), GHPO712(SEQ ID NO: 20), GHPO761(SEQ ID NO: 22), GHPO 838(SEQ ID NO: 24), GHPO 1034(SEQ ID NO: 26), GHPO 1085(SEQ ID NO: 28), GHPO1213(SEQ ID NO: 30), GHPO1255(SEQ ID NO: 32), GHPO (SEQ ID NO: 34), GHPO 9(SEQ ID NO: 36), GHPO 1706(SEQ ID NO: 38), GHPO234(SEQ ID NO: 40), GHPO314(SEQ ID NO: 42), GHPO 510(SEQ ID NO: 44), GHPO 603(SEQ ID NO: 46), GHPO 937(SEQ ID NO: 48), GHPO1027(SEQ ID NO: 50), GHPO1099(SEQ ID NO: 52), GHPO 1151(SEQ ID NO: 54), GHPO 1275(SEQ ID NO: 56), GHPO 1365(SEQ ID NO: 58), GHPO 8(SEQ ID NO: 60), GHPO22(SEQ ID NO: 62), GHPO58 (SEQ ID NO: 64), GHPO 200(SEQ ID NO: 66), GHPO 558(SEQ ID NO: 68), GHPO563(SEQ ID NO: 70), GHPO 695(SEQ ID NO: 72), GHPO 9(SEQ ID NO: 6974), GHPO 702(SEQ ID NO: 709 NO: 76), GHPO (SEQ ID NO: 78), GHPO741(SEQ ID NO: 80), GHPO 762(SEQ ID NO: 82), GHPO 827(SEQ ID NO: 84), GHPO 852(SEQ ID NO: 86), GHPO1013(SEQ ID NO: 88), GHPO1020(SEQ ID NO: 90), GHPO 1031(SEQ ID NO: 92), GHPO 1052(SEQ ID NO: 94), GHPO 1127(SEQ ID NO: 96), GHPO1149(SEQ ID NO: 98), GHPO1176(SEQ ID NO: 100), GHPO 1250(SEQ ID NO: 102), GH PO 1312(SEQ ID NO: 104), GHPO 1358(SEQ ID NO: 106), GHPO 1490(SEQ ID NO: 108), GHPO 1559(SEQ ID NO: 110), GHPO 1651(SEQ IDNO: 112), GHPO 1726(SEQ ID NO: 114), GHPO 1780(SEQ ID NO: 116), GHPO 895(SEQ ID NO: 89118), GHPO 1447(SEQ ID NO: 144120), GHPO28 (SEQ ID NO: 122), GHPO86(SEQ ID NO: 124), GHPO 155(SEQ ID NO: 126), GHPO157 (SEQ ID NO: 128), GHPO 237(SEQ ID NO: 130), GHPO 290(SEQ ID NO: 132), GHPO293(SEQ ID NO: 134), GHPO 335(SEQ ID NO: 136), GHPO 374(SEQ ID NO: 138), GHPO 442(SEQ ID NO: 140), GHPO 480(SEQ ID NO: 142), GHPO523(SEQ ID NO: 144), GHPO610(SEQ ID NO: 146), GHPO 675(SEQ ID NO: 148), GHPO 690(SEQ ID NO: 150), GHPO 829(SEQ ID NO: 152), GHPO850(SEQ ID NO: 154), GHPO876(SEQ ID NO: 156), GHPO 984(SEQ ID NO: 158), GHPO 989(SEQ ID NO: 160), GHPO (SEQ ID NO: 1111), GHPO 1145(SEQ ID NO: 164), GHPO 1256(SEQ ID NO: 166), GHPO 1264(SEQ ID NO: 168), GHPO 1316(SEQ ID NO: 170), GHPO 1368(SEQ ID NO: 172), GHPO 1442(SEQ ID NO: 174), GHPO 1506(SEQ ID NO: 176), GHPO 1543(SEQ ID NO: 178), GHPO 1574(SEQ ID NO: 180), GHPO 1627(SEQ ID NO: 182), GHPO 1657(SEQ ID NO: 184), GHPO 1664(SEQ ID NO: 186), GHPO 94(SEQ ID NO: 1693), GHPO (SEQ ID NO: 1704 NO: 190), GHPO 1763(SEQ ID NO: 192), GHPO 616(SEQ ID NO: 194), GHPO76 (SEQ ID NO: 196), GHPO109 (SEQ ID NO: 198), GHPO (SEQ ID NO: 163), GHPO163 (SEQ ID NO: 200), GHPO 169(SEQ ID NO: 202), GHPO 208: 204), GHPO219(SEQ ID NO: 206), GHPO 445(SEQ ID NO: 208), GHPO 479(SEQ ID NO: 210), GHPO 525(SEQ ID NO: 212), GHPO 535(SEQ ID NO: 214), GHPO731(SEQ ID NO: 216), GHPO836(SEQ ID NO: 218), GHPO 879(SEQ ID NO: 220), GHPO 881(SEQ ID NO: 222), GHPO 886(SEQ ID NO: 224), GHPO893(SEQ ID NO: 226), GHPO894(SEQ ID NO: 228), GHPO 976(SEQ ID NO: 230), GHPO 1011(SEQ ID NO: 232), GHPO 1024(SEQ ID NO: 234), GHPO 1084(SEQ ID NO: 236), GHPO 1329(SEQ ID NO: 238), GHPO (SEQ ID NO: 240), GHPO 1346(SEQ ID NO: 242), GHPO (SEQ ID NO: 244), GHPO (SEQ ID NO: 8), GHPO 1388(SEQ ID NO: 1381388), GHPO 1411(SEQ ID NO: 248), GHPO 1419(SEQ ID NO: 250), GHPO 1446(SEQ ID NO: 252), GHPO 1469(SEQ ID NO: 254), GHPO 1501(SEQ ID NO: 256), GHPO 1505(SEQ ID NO: 258), GHPO 1522(SEQ ID NO: 260), GHPO 5(SEQ ID NO: 262), GHPO 1615(SEQ ID NO: 264), GHPO 1689(SEQ ID NO: 266), GHPO 1733(SEQ ID NO: 268), GHPO18 (SEQ ID NO: 270), GHPO 139(SEQ ID NO: 272), GHPO142 (SEQ ID NO: 274), GHPO 250(SEQ ID NO: 276), GHPO257(SEQ ID NO: 278), GHPO325(SEQ ID NO: 280), GHPO 355(SEQ ID NO: 282), GHPO 357(SEQ ID NO: 286), GHPO 454(SEQ ID NO: 286), GHPO475(SEQ ID NO: 288), GHPO515(SEQ ID NO: 290), GHPO 527(SEQ ID NO: 292), GHPO 551(SEQ ID NO: 294), GHPO 602(SEQ ID NO: 296), GHPO626(SEQ ID NO: 298), GHPO646(SEQ ID NO: 300), GHPO 653(SEQ ID NO: 302), GHPO 655(SEQ ID NO: 304), GHPO 670(SEQ ID NO: 306), GHPO739(SEQ ID NO: 308), GHPO798(SEQ ID NO: 310), GHPO 1102(SEQ ID NO: 312), GHPO 1114(SEQ ID NO: 314), GHPO 1152(SEQ ID NO: 316), GHPO 1272(SEQ ID NO: 318), GH134PO 5(SEQ ID NO: 320), GHPO 1377(SEQ ID NO: 322), GHPO 1424(SEQ ID NO: 324), GHPO 1430(SEQ ID NO: 326), GHPO (SEQ ID NO: 328), GHPO 1600(SEQ ID NO: 1502), GHPO 1714(SEQ ID NO: 332), GHPO 359(SEQ ID NO: 334), GHPO 678(SEQ ID NO: 336), GHPO 708(SEQ ID NO: 338), GHPO 759(SEQ ID NO: 340), GHPO 847(SEQ ID NO: 342), GHPO 1050(SEQ ID NO: 344), GHPO 1101(SEQ ID NO: 346), GHPO 1120(SEQ ID NO: 348), GHPO 1138(SEQ ID NO: 350), GHPO 1310(SEQ ID NO: 352), GHPO 1320(SEQ ID NO: 354), GHPO 1375(SEQ ID NO: 356), GHPO 1432(SEQ ID NO: 358), GHPO21 (SEQ ID NO: 360), GHPO282(SEQ ID NO: 362), GHPO 1089(SEQ ID NO: 364), GHPO 1141(SEQ ID NO: 366), GHPO 0(SEQ ID NO: 368), GHPO 1608(SEQ ID NO: 370), GHPO15 (SEQ ID NO: 372), GHPO16(SEQ ID NO: 374), GHPO36 (SEQ ID NO: 376), GHPO38 (SEQ ID NO: 378), GHPO52 (SEQ ID NO: 380), GHPO57(SEQ ID NO: 382), GHPO64(SEQ ID NO: 384), GHPO79 (SEQ ID NO: 386), GHPO84 (SEQ ID NO: 388), GHPO86(SEQ ID NO: 390), GHPO99(SEQ ID NO: 392), GHPO106(SEQ ID NO: 382), GHPO 118(SEQ ID NO: 396), GHPO 122(SEQ ID NO: 398), GHPO128 (SEQ ID NO: 400), GHPO138(SEQ ID NO: 394), GHPO153(SEQ ID NO: 404), GHPO 160(SEQ ID NO: 406), GHPO 168(SEQ ID NO: 408), GHPO 179(SEQ ID NO: 410), GHPO189(SEQ ID NO: 412), GHPO229(SEQ ID NO: 414), GHPO 243(SEQ ID NO: 416), GHPO 244(SEQ ID NO: 418), GHPO 251(SEQ ID NO: 420), GHPO267(SEQ ID NO: 422), GHPO269(SEQ IDNO: 424), GHPO 279(SEQ ID NO: 426), GHPO 284(SEQ ID NO: 428), GHPO296 (SEQ ID NO: 430), GHPO300(SEQ ID NO: 432), GHPO305(SEQ ID NO: 434), GHPO 319(SEQ ID NO: 436), GHPO 330(SEQ ID NO: 438), GHPO 340(SEQ ID NO: 440), GHPO342(SEQ ID NO: 442), GHPO344(SEQ ID NO: 444), GHPO 358(SEQ ID NO: 446), GHPO 373(SEQ ID NO: 448), GHPO 382(SEQ ID NO: 398), GHPO384(SEQ ID NO: 458), GHPO384(SEQ ID NO: 452), GHPO 454), GHPO 409(SEQ ID NO: 456), GHPO 422(SEQ ID NO: 456), GHPO 430(SEQ ID NO: 460), GHPO446(SEQ ID NO: 462), GHPO447(SEQ ID NO: 464), GHPO 450(SEQ ID NO: 466), GHPO 451(SEQ ID NO: 468), GHPO 452(SEQ ID NO: 470), GHPO456(SEQ ID NO: 472), GHPO461(SEQ ID NO: 474), GHPO 476(SEQ ID NO: 476), GHPO 478(SEQ ID NO: 478), GHPO 491(SEQ ID NO: 480), GHPO511(SEQ ID NO: 482), GHPO519(SEQ ID NO: 484), GHPO 526(SEQ ID NO: 486), GHPO 534(SEQ ID NO: 488), GHPO 536(SEQ ID NO: 490), GHPO542(SEQ ID NO: 492), GHPO544(SEQ ID NO: 494), GHPO (SEQ ID NO: 496), GHPO 498(SEQ ID NO: 578), GHPO 580(SEQ ID NO: 500), GHPO585(SEQ ID NO: 502), GHPO599(SEQ ID NO: 504), GHPO 639(SEQ ID NO: 506), GHPO 642(SEQ ID NO: 508), GHPO 647(SEQ ID NO: 510), GHPO654(SEQ ID NO: 512), GHPO669(SEQ ID NO: 514), GHPO 710(SEQ ID NO: 516), GHPO 713(SEQ ID NO: 518), GHPO 716(SEQ ID NO: 520), GHPO718(SEQ ID NO: 522), GHPO726(SEQ ID NO: 524), GHPO 734(SEQ ID NO: 526), GHPO 740(SEQ ID NO: 528), GHPO 770(SEQ ID NO: 530), GHPO782(SEQ ID NO: 532), GHPO786(SEQ ID NO: 534), GHPO 792(SEQ ID NO: 536), GHPO 797(SEQ ID NO: 538), GHPO 816(SEQ ID NO: 540), GHPO (SEQ ID NO: 542), GHPO 79828), GHPO (SEQ ID NO: 542: 83828), GHPO840 (SEQ ID NO: 546), GHPO 842(SEQ ID NO: 548), GHPO 885(SEQ ID NO: 550), GHPO889(SEQ ID NO: 552), GHPO903(SEQ ID NO: 554), GHPO 912(SEQ ID NO: 556), GHPO 946(SEQ ID NO: 558), GHPO 958(SEQ ID NO: 560), GHPO968(SEQ ID NO: 562), GHPO987(SEQ ID NO: 564), GHPO 992(SEQ ID NO: 566), GHPO 996(SEQ ID NO: 568), GHPO 997(SEQ ID NO: 570), GHPO1002(SEQ ID NO: 572), GHPO (SEQ ID NO: 574), GHPO 1028 PO (SEQ ID NO: 576), GHPO (SEQ ID NO: 1034), GHPO 1038(SEQ ID NO: 580), GHPO 1059(SEQID NO: 582), GHPO 1065(SEQ ID NO: 586), GHPO 1072(SEQ ID NO: 586), GHPO 1073(SEQ ID NO: 588), GHPO 1088(SEQ ID NO: 590), GHPO 1091(SEQ ID NO: 592), GHPO 1105(SEQ ID NO: 594), GHPO 1115(SEQ ID NO: 596), GHPO 1159(SEQ ID NO: 598), GHPO 1177(SEQ ID NO: 600), GHPO 1187(SEQ ID NO: 602), GHPO 1192(SEQ ID NO: 604), GHPO 1195(SEQ ID NO: 606), GHPO 1224(SEQ ID NO: 608), GHPO 1225(SEQ ID NO: 610), GHPO 1228(SEQ ID NO: 612), GHPO 1229(SEQ ID NO: 614), GHPO 1231(SEQ ID NO: 616), GHPO 1236(SEQ ID NO: 618), GHPO 1242(SEQ ID NO: 620), GHPO 8(SEQ ID NO: 622), GHPO 1270(SEQ ID NO: 624), GHPO 1271(SEQ ID NO: 1271), GHPO 124626), GHPO 628(SEQ ID NO: 628), GHPO 1301(SEQ ID NO: 630), GHPO 1304(SEQ ID NO: 632), GHPO 1315(SEQ ID NO: 634), GHPO 1319(SEQ ID NO: 636), GHPO 1323(SEQ ID NO: 638), GHPO 1331(SEQ ID NO: 640), GHPO 1332(SEQ ID NO: 642), GHPO 1347(SEQ ID NO: 644), GHPO 1373(SEQ ID NO: 646), GHPO 1376(SEQ ID NO: 648), GHPO 1380(SEQ ID NO: 650), GHPO 1394(SEQ ID NO: 652), GHPO 1407(SEQ ID NO: 654), GHPO 5(SEQ ID NO: 656), GHPO 1425(SEQ ID NO: 658), GHPO 1427(SEQ ID NO: 141660), GHPO 1444(SEQ ID NO: 662), GHPO 1449(SEQ ID NO: 664), GHPO 1465(SEQ ID NO: 666), GHPO 1475(SEQ ID NO: 670), GHPO 1479(SEQ ID NO: 670), GHPO 1483(SEQ ID NO: 672), GHPO 1488(SEQ ID NO: 674), GHPO 1496(SEQ ID NO: 676), GHPO 1524(SEQ ID NO: 678), GHPO 1536(SEQ ID NO: 680), GHPO 1539(SEQ ID NO: 682), GHPO 1540(SEQ ID NO: 684), GHPO 1542(SEQ ID NO: 686), GHPO 1555(SEQ ID NO: 688), GHPO 1560(SEQ ID NO: 690), GHPO 1564(SEQ ID NO: 692), GHPO 1570(SEQ ID NO: 694), GHPO 8(SEQ ID NO: 696), GHPO 1604(SEQ ID NO: 698), Gm O1555 (SEQ ID NO: 700), GHPO 1619(SEQ ID NO: 702), GHPO 1629(SEQ ID NO: 704), GHPO 164706 (SEQ ID NO: 157706), GHPO 1654(SEQ ID NO: 1664), GHPO 1661(SEQ ID NO: 160712), GHPO 710), GHPO 1687(SEQ ID NO: 714), GHPO 1692(SEQ ID NO: 716), GHPO 1693(SEQ ID NO: 718), GHPO 1699(SEQ ID NO: 720), GHPO 1738(SEQ ID NO: 722), GHPO 1745(SEQ ID NO: 724), GHPO 1746(SEQ ID NO: 726), GHPO 1754(SEQ ID NO: 728), GHPO 1792(SEQ ID NO: 730), GHPO 1795(SEQ ID NO: 732), GHPO 1796(SEQ ID NO: 734), GHPO 7(SEQ ID NO: 736), GHPO 8(SEQ ID NO: 738), GHPO 9(SEQ ID NO: 740), GHPO10 (SEQ ID NO: 742), GHPO12 (SEQ ID NO: 744), GHPO25(SEQ ID NO: 746), GHPO27 (SEQ ID NO: 748), GHPO29 (SEQ ID NO: 750), GHPO30 (SEQ ID NO: 754), GHPO 37(SEQ ID NO: 752), GHPO49(SEQ ID NO: 756), GHPO51(SEQ ID NO: 758), GHPO54 (SEQ ID NO: 760), GHPO65 (SEQ ID NO: 762), GHPO66 (SEQ ID NO: 764), GHPO68(SEQ ID NO: 766), GHPO70(SEQ ID NO: 768), GHPO 77(SEQ ID NO: 770), GHPO83 (SEQ ID NO: 772), GHPO85 (SEQ ID NO: 774), GHPO87(SEQ ID NO: 776), GHPO91(SEQ ID NO: 778), GHPO 92(SEQ ID NO: 780), GHPO96 (SEQ ID NO: 782), GHPO 97(SEQ ID NO: 784), GHPO111(SEQ ID NO: 786), GHPO115(SEQ ID NO: 788), GHPO117 (SEQ ID NO: 790), GHPO 123(SEQ ID NO: 124), GHPO 124(SEQ ID NO: 794), GHPO126(SEQ ID NO: 796), GHPO127(SEQ ID NO: 798), GHPO128 (SEQ ID NO: 800), GHPO 131(SEQ ID NO: 802), GHPO 133(SEQ ID NO: 804), GHPO140(SEQ ID NO: 806), GHPO141(SEQ ID NO: 808), GHPO 145(SEQ ID NO: 810), GHPO147 (SEQ ID NO: 812), GHPO 166(SEQ ID NO: 814), GHPO181(SEQ ID NO: 816), GHPO187 (SEQ ID NO: 818), GHPO 188(SEQ ID NO: 820), GHPO 192(SEQ ID NO: 822), GHPO 202(SEQ ID NO: 824), GHPO204(SEQ ID NO: 826), GHPO205(SEQ ID NO: 828), GHPO 212(SEQ ID NO: 834), GHPO 218(SEQ ID NO: 832), GHPO (SEQ ID NO: 226), GHPO231(SEQ ID NO: 836), GHPO236(SEQ ID NO: 838), GHPO 239(SEQ ID NO: 840), GHPO 245(SEQ ID NO: 842), GHPO 246(SEQ ID NO: 844), GHPO248(SEQ ID NO: 846), GHPO253(SEQ ID NO: 848), GHPO 265(SEQ ID NO: 850), GHPO 266(SEQ ID NO: 852), GHPO 271(SEQ ID NO: 854), GHPO272(SEQ ID NO: 856), GHPO286(SEQ ID NO: 858), GHPO 291(SEQ ID NO: 860), GHPO 292(SEQ ID NO: 862), GHPO 297(SEQ ID NO: 864), GHPO304(SEQ ID NO: 866), GHPO307(SEQ ID NO: 868), GHPO 324(SEQ ID NO: 870), GHPO 326(SEQ ID NO: 872), GHPO 331(SEQ ID NO: 874), GHPO343(SEQ ID NO: 876), GHPO345(SEQ ID NO: 878), GHPO (SEQ ID NO: 880), GHPO 352: 882), GHPO 355(SEQ ID NO: 884), GHPO363(SEQ ID NO: 886), GHPO369(SEQ ID NO: 888), GHPO (SEQ ID NO: 890), GHPO 378(SEQ ID NO: 892), GHPO 388(SEQ ID NO: 894), GHPO396(SEQ ID NO: 896), GHPO403(SEQ ID NO: 898), GHPO 410(SEQ ID NO: 900), GHPO 415(SEQ ID NO: 902), GHPO 421(SEQ ID NO: 904), GHPO439(SEQ ID NO: 906), GHPO441(SEQ ID NO: 908), GHPO 443(SEQ ID NO: 910), GHPO 453(SEQ ID NO: 912), GHPO (SEQ ID NO: 914), GHPO (SEQ ID NO: 916), GHPO 916 (SEQ ID NO: 455), GHPO467(SEQ ID NO: 918), GHPO 468(SEQ ID NO: 920), GHPO 470(SEQ ID NO: 922), GHPO 486(SEQ ID NO: 924), GHPO487(SEQ ID NO: 926), GHPO488(SEQ ID NO: 928), GHPO 489(SEQ ID NO: 930), GHPO 498(SEQ ID NO: 932), GHPO 501(SEQ ID NO: 934), GHPO504(SEQ ID NO: 936), GHPO512(SEQ ID NO: 938), GHPO 517(SEQ ID NO: 940), GHPO 520(SEQ ID NO: 942), GHPO 528(SEQ ID NO: 944), GHPO530(SEQ ID NO: 946), GHPO532(SEQ ID NO: 948), GHPO 548(SEQ ID NO: 950), GHPO 561(SEQ ID NO: 952), GHPO 564(SEQ ID NO: 954), GHPO572(SEQ ID NO: 956), GH4PO 573(SEQ ID NO: 958), GHPO 574 (96O: 960), GHPO 577(SEQ ID NO: 962), GHPO 579(SEQ ID NO: 964), GHPO583(SEQ ID NO: 588), GHPO 4: 588), GHPO 574(SEQ ID NO: 968), GHPO 593(SEQ ID NO: 970), GHPO 597(SEQ ID NO: 972), GHPO 598(SEQ ID NO: 974), GHPO604(SEQ ID NO: 976), GHPO606(SEQ ID NO: 978), GHPO 611(SEQ ID NO: 980), GHPO 612(SEQ ID NO: 982), GHPO615 (SEQ ID NO: 984), GHPO632(SEQ ID NO: 986), GHPO633(SEQ ID NO: 988), GHPO 637(SEQ ID NO: 990), GHPO 651(SEQ ID NO: 992), GHPO 663(SEQ ID NO: 994), GHPO686(SEQ ID NO: 996), GHPO693(SEQ ID NO: 998), GHPO 698(SEQ ID NO: 1000), GHPO 703(SEQ ID NO: 1002), GHPO 704(SEQ ID NO: 1004), GHPO (SEQ ID NO: 721), GHPO (SEQ ID NO: 1008), GHPO (SEQ ID NO: 1010 NO: 1008), GHPO 1010 NO: 1010, GHPO 727(SEQ ID NO: 1012), GHPO 728(SEQ ID NO: 1014), GHPO 733(SEQ ID NO: 1016), GHPO 758(SEQ ID NO: 1018), GHPO 763(SEQ ID NO: 1020), GHPO 771(SEQ ID NO: 1022), GHPO 774(SEQ ID NO: 1024), GHPO 776(SEQ ID NO: 1026), GHPO 783(SEQ ID NO: 1028), GHPO 800(SEQ ID NO: 1030), GHPO 806(SEQ ID NO: 1032), GHPO 807(SEQ ID NO: 1034), GHPO 808(SEQ ID NO: 1036), GHPO 809(SEQ ID NO: 8), GHPO 811(SEQ ID NO: 1040), GHPO 815(SEQ ID NO: 1031042), GHPO 819(SEQ ID NO: 1044), GHPO 841(SEQ ID NO: 1046), GHPO 843(SEQ ID NO: 1048), GHPO (846 NO:1048), GHPO (SEQ ID NO: 1050), GHPO (SEQ ID NO: 875), GHPO 892(SEQ ID NO: 1054), GHPO 902(SEQ ID NO: 1056), GHPO 904(SEQ ID NO: 1058), GHPO 906(SEQ ID NO: 1060), GHPO 908(SEQ ID NO: 1062), GHPO 921(SEQ ID NO: 1064), GHPO 923(SEQ ID NO: 1066), GHPO 926(SEQ ID NO: 1068), GHPO 933(SEQ ID NO: 1070), GHPO 939(SEQ ID NO: 1072), GHPO 940(SEQ ID NO: 1074), GHPO 943(SEQ ID NO: 1076), GHPO 951(SEQ ID NO: 1078), GHPO961 (SEQ ID NO: 1080), GHPO 965(SEQ ID NO: 1082), GHPO 990(SEQ ID NO: 1084), GHPO 991(SEQ ID NO: 1086), GHPO 998(SEQ ID NO: 1088), GHPO 1001(SEQ ID NO: 1005), GHPO 1032 (SEQ ID NO: 1093, GHPO 1093), GHPO1039 (SEQ ID NO: 1096), GHPO 1041(SEQ ID NO: 1098), GHPO 1043(SEQ ID NO: 1100), GHPO 1044(SEQ ID NO: 1102), GHPO 1051(SEQ ID NO: 1104), GHPO 1058(SEQ ID NO: 1106), GHPO 1060(SEQ ID NO: 1108), GHPO 1075(SEQ ID NO: 1110), GHPO1077(SEQ ID NO: 1112), GHPO1082(SEQ ID NO: 1114), GHPO 1083(SEQ ID NO: 1116), GHPO 1086(SEQ ID NO: 1118), GHPO 1087(SEQ ID NO: 1120), GHPO 1090(SEQ ID NO: 1122), GHPO 1097(SEQ ID NO: 1124), GHPO 1098(SEQ ID NO: 1126), GHPO 1103(SEQ ID NO: 1128), GHPO1113(SEQ ID NO: 1116), GHPO 1133 (SEQ ID NO: 1130), GHPO (SEQ ID NO: 1132), GHPO 1133 (SEQ ID NO: 1134), GHPO 1125 NO: 11256), GHPO 1129(SEQ ID NO: 1138), GHPO 1130(SEQ ID NO: 1140), GHPO 1134(SEQ ID NO: 1142), GHPO 1161(SEQ ID NO: 1144), GHPO 1166(SEQ ID NO: 1146), GHPO1170(SEQ ID NO: 1148), GHPO1175(SEQ ID NO: 1150), GHPO 1181(SEQ ID NO: 1152), GHPO 1186(SEQ ID NO: 1154), GHPO 1188(SEQ ID NO: 1156), GHPO 1191(SEQ ID NO: 1158), GHPO 1193(SEQ ID NO: 1160), GHPO 1196(SEQ ID NO: 1162), GHPO 1204(SEQ ID NO: 1164), GHPO1210(SEQ ID NO: 1166), GHPO1211(SEQ ID NO: 1168), GHPO 1216(SEQ ID NO: 1170), GHPO 1218(SEQ ID NO: 1221172), GHPO 1220(SEQ ID NO: 1224), GHPO 1220, GHPO1211(SEQ ID NO: 1176), GHPO 1178), GHPO 1240(SEQ ID NO: 1180), GHPO 1246(SEQ ID NO: 1182), GHPO1251(SEQ ID NO: 1184), GHPO1252(SEQ ID NO: 1186), GHPO 1261(SEQ ID NO: 1188), GHPO 1265(SEQ ID NO: 1190), GHPO 1267(SEQ ID NO: 1192), GHPO 1278(SEQ ID NO: 1194), GHPO1282 (SEQ ID NO: 1196), GHPO 1283(SEQ ID NO: 1198), GHPO 1287(SEQ ID NO: 1200), GHPO1292(SEQ ID NO: 1202), GHPO1293(SEQ ID NO: 1204), GHPO 1302(SEQ ID NO: 1206), GHPO 1309(SEQ ID NO: 1208), GHPO 1317(SEQ ID NO: 1210), GHPO 8(SEQ ID NO: 1212), GHPO 1321(SEQ ID NO: 1214), GHPO 1325(SEQ ID NO: 1341), GHPO 1216, GHPO 1311 (SEQ ID NO: 1220), GHPO1354(SEQ ID NO: 1222), GHPO 1363(SEQ ID NO: 1224), GHPO 1371(SEQ ID NO: 1226), GHPO 1381(SEQ ID NO: 1228), GHPO 1401(SEQ ID NO: 1230), GHPO 1402(SEQ ID NO: 1232), GHPO 1403(SEQ ID NO: 1234), GHPO 1408(SEQ ID NO: 1236), GHPO1416(SEQ ID NO: 1238), GHPO1420(SEQ ID NO: 1240), GHPO 1428(SEQ ID NO: 1242), GHPO 1437(SEQ ID NO: 1244), GHPO 1439(SEQ ID NO: 1246), GHPO 1460(SEQ ID NO: 1248), GHPO 3(SEQ ID NO: 1461250), GHPO 1472(SEQ ID NO: 1252), GHPO 1474(SEQ ID NO: 1254), GHPO1484(SEQ ID NO: 1256), GHPO1489(SEQ ID NO: 1258), GHPO 1254 (SEQ ID NO: 1494), GHPO 1495(SEQ ID NO: 1491260), GHPO 1498(SEQ ID NO: 1264), GHPO 1499(SEQ ID NO: 1266), GHPO 1500(SEQ ID NO: 1268), GHPO 1503(SEQ ID NO: 1270), GHPO 1504(SEQ ID NO: 1272), GHPO1510(SEQ ID NO: 1274), GHPO1518(SEQ ID NO: 1276), GHPO 1533(SEQ ID NO: 1278), GHPO 1541(SEQ ID NO: 1280), GHPO 1544(SEQ ID NO: 1282), GHPO 8(SEQ ID NO: 1284), GHPO 1565(SEQ ID NO: 1286), GHPO 1575(SEQ ID NO: 1288), GHPO 1582(SEQ ID NO: 1290), GHPO1595(SEQ ID NO: 1292), GHPO 1547 (SEQ ID NO: 1544), GHPO 9(SEQ ID NO: 1291601 6), GHPO (SEQ ID NO: 1588), GHPO (SEQ ID NO: 1300), GHPO 1599(SEQ ID NO: 1611603), GHPO 1593 (SEQ ID NO: 1594), GHPO 1626(SEQ ID NO: 1306), GHPO 1628(SEQ ID NO: 1308), GHPO1639(SEQ ID NO: 1310), GHPO1640(SEQ ID NO: 1312), GHPO 1641(SEQ ID NO: 1314), GHPO 1646(SEQ ID NO: 1316), GHPO 1662(SEQ ID NO: 1318), GHPO 1667(SEQ ID NO: 1320), GHPO 1668(SEQ ID NO: 1322), GHPO 1670(SEQ ID NO: 1324), GHPO 1671(SEQ ID NO: 1326), GHPO1672(SEQ ID NO: 1328), GHPO1678 (SEQ ID NO: 1330), GHPO 1684(SEQ ID NO: 1332), GHPO 1699(SEQ ID NO: 1334), GHPO 1697(SEQ ID NO: 1699), GHPO 1701(SEQ ID NO: 1338), GHPO1719(SEQ ID NO: 1340), GHPO 1343 (SEQ ID NO: 1342), GHPO 1342 (SEQ ID NO: 1731349), GHPO 1349 (SEQ ID NO: 1344), GHPO1741(SEQ ID NO: 1348), GHPO 1747(SEQ ID NO: 1350), GHPO 1749(SEQ ID NO: 1352), GHPO 1750(SEQ ID NO: 1354), GHPO 1751(SEQ ID NO: 1356), GHPO 1755(SEQ ID NO: 1358), GHPO 1771(SEQ ID NO: 1360), GHPO 1786(SEQ ID NO: 1362), and GHPO1789(SEQ ID NO: 1364), for example, these polypeptides may be used in an immunological method for preventing or treating helicobacter infection. For example, it has been demonstrated
GHPO 1320, GHPO523, GHPO 792, GHPO 639, GHPO669, GHPO 992, GHPO 576, GHPO109, GHPO129, GHPO234, GHPO257, GHPO 525, GHPO626, GHPO 1034, GHPO 1275, GHPO 1308, GHPO 1600, GHPO 1615, GHPO 536, GHPO66, GHPO 1363, GHPO1595, and GHPO 1166 are protective antigens that can be used in methods for preventing helicobacter infection. "protective antigen" refers to an antigen that reduces the level of infection after challenge relative to a positive control. Absolute protection is not necessary, although the present invention includes absolute protection.
Certain novel polypeptides are secreted polypeptides which may be produced in their mature form (i.e., polypeptides which are excreted via the type II or type III secretory pathway) or in a precursor form which includes a signal peptide which may be removed during the secretion/secretion process by cleaving the N-terminus of its mature form. (the cleavage site is located at the C-terminus of the signal peptide, adjacent to its mature form).
According to a first aspect of the present invention there is provided an isolated polynucleotide encoding the aforementioned pro-and mature forms of helicobacter GHPO protein. Examples of such polynucleotides are polynucleotides encoding the following sequences:
GHPO 35(SEQ ID NO: 1), GHPO 55(SEQ ID NO: 3), GHPO78 (SEQ ID NO: 5), GHPO89 (SEQ ID NO: 7), GHPO129(SEQ ID NO: 9), GHPO 541(SEQ ID NO: 11), GHPO 607(SEQ ID NO: 13), GHPO 635(SEQ ID NO: 15), GHPO 701(SEQ ID NO: 17), GHPO712(SEQ ID NO: 19), GHPO761(SEQ ID NO: 21), GHPO 838(SEQ ID NO: 23), GHPO 1034(SEQ ID NO: 25), GHPO 1085(SEQ ID NO: 27), GHPO1213(SEQ ID NO: 29), GHPO1255(SEQ ID NO: 31), GHPO 1308(SEQ ID NO: 33), GHPO 1389(SEQ ID NO: 35), GHPO 1706(SEQ ID NO: 37), GHPO234(SEQ ID NO: 39), GHPO314(SEQ ID NO: 41), GHPO 510(SEQ ID NO: 43), GHPO 603(SEQ ID NO: 45), GHPO 937(SEQ ID NO: 47), GHPO1027(SEQ ID NO: 49), GHPO1099(SEQ ID NO: 51), GHPO 1151(SEQ ID NO: 53), GHPO 1275(SEQ ID NO: 55), GHPO 1365(SEQ ID NO: 57), GHPO1578(SEQ ID NO: 59), GHPO22(SEQ ID NO: 61), GHPO58 (SEQ ID NO: 63), GHPO 200(SEQ ID NO: 65), GHPO 558(SEQ ID NO: 67), GHPO563(SEQ ID NO: 69), GHPO 695(SEQ ID NO: 71), GHPO 699(SEQ ID NO: 73), GHPO 702(SEQ ID NO: 75), GHPO709(SEQ ID NO: 77), GHPO (SEQ ID NO: 741), GHPO 762(SEQ ID NO: 81), GHPO83 (SEQ ID NO: 827), GHPO 852(SEQ ID NO: 85), GHPO1013(SEQ ID NO: 87), GHPO1020(SEQ ID NO: 89), GHPO 1031(SEQ ID NO: 91), GHPO 1052(SEQ ID NO: 93), GHPO 1127(SEQ ID NO: 95), GHPO1149(SEQ ID NO: 97), GHPO1176(SEQ ID NO: 99), GHPO 1250(SEQ ID NO: 101), GHPO 1312(SEQ ID NO: 103), GHPO 1358(SEQ ID NO: 105), GHPO 1490(SEQ ID NO: 107), GHPO 1559(SEQ ID NO: 109), GHPO 1651(SEQ ID NO: 111), GHPO 1726(SEQ ID NO: 113), GHPO 1780(SEQ ID NO: 115), GHPO 895(SEQ ID NO: 117), GHPO 1447(SEQ ID NO: 119), GHPO28 (SEQ ID NO: 121), GHPO86(SEQ ID NO: 123), GHPO 155(SEQ ID NO: 125), GHPO157 (SEQ ID NO: 127), GHPO 237(SEQ ID NO: 129), GHPO 290(SEQ ID NO: 131), GHPO293(SEQ ID NO: 133), GHPO 335(SEQ ID NO: 135), GHPO 374(SEQ ID NO: 137), GHPO 442(SEQ ID NO: 139), GHPO 480(SEQ ID NO: 141), GHPO523(SEQ ID NO: 143), GHPO610(SEQ ID NO: 145), GHPO 675(SEQ ID NO: 147), GHPO 690(SEQ ID NO: 149), GHPO 829(SEQ ID NO: 151), GHPO850(SEQ ID NO: 153), GHPO876(SEQ ID NO: 155), GHPO 984(SEQ ID NO: 157), GHPO 989(SEQ ID NO: 159), GHPO 1111(SEQ ID NO: 161), GHPO 1145(SEQ ID NO: 163), GHPO 1256(SEQ ID NO: 165), GHPO 1264(SEQ ID NO: 126167), GHPO 1316(SEQ ID NO: 169), GHPO 1368(SEQ ID NO: 171), GHPO 1442(SEQ ID NO: 173), GHPO 1506(SEQ ID NO: 175), GHPO 1543(SEQ ID NO: 177), GHPO 1574(SEQ ID NO: 179), GHPO 1627(SEQ ID NO: 181), GHPO 1657(SEQ ID NO: 183), GHPO 1664(SEQ ID NO: 185), GHPO 1694(SEQ ID NO: 187), GHPO 1704(SEQ ID NO: 189), GHPO 1763(SEQ ID NO: 191), GHPO 616(SEQ ID NO: 193), GHPO76 (SEQ ID NO: 195), GHPO109 (SEQ ID NO: 197), GHPO163 (SEQ ID NO: 199), GHPO (SEQ ID NO: 169), GHPO 208(SEQ ID NO: 203), GHPO219(SEQ ID NO: 205), GHPO (SEQ ID NO: 207), GHPO 479(SEQ ID NO: 209), GHPO 525(SEQ ID NO: 211), GHPO 535(SEQ ID NO: 213), GHPO731(SEQ ID NO: 215), GHPO836(SEQ ID NO: 217), GHPO 879(SEQ ID NO: 219), GHPO 881(SEQ ID NO: 221), GHPO 886(SEQ ID NO: 223), GHHPO 893(SEQ ID NO: 225), GHPO894(SEQ ID NO: 227), GHPO 976(SEQ ID NO: 229), GHPO 1011(SEQ ID NO: 231), GHPO 1024(SEQ ID NO: 233), GHPO 1084(SEQ ID NO: 235), GHPO 1329(SEQ ID NO: 237), GHPO (SEQ ID NO: 239), GHPO 1346(SEQ ID NO: 241), GHPO 1360(SEQ ID NO: 243), GHPO 1388(SEQ ID NO: 141245), GHPO 1(SEQ ID NO: 247), GHPO 9(SEQ ID NO: 1411449), GHPO 1446(SEQ ID NO: 251), GHPO 1469(SEQ ID NO: 253), GHPO 1501(SEQ ID NO: 255), GHPO 1505(SEQ ID NO: 257), GHPO 1522(SEQ ID NO: 259), GHPO 1525(SEQ ID NO: 261), GHPO 1615(SEQ ID NO: 263), GHPO 1689(SEQ ID NO: 265), GHPO 1733(SEQ ID NO: 267), GHPO18 (SEQ ID NO: 269), GHPO 139(SEQ ID NO: 271), GHPO142 (SEQ ID NO: 273), GHPO 250(SEQ ID NO: 275), GHPO257(SEQ ID NO: 277), GHPO325(SEQ ID NO: 279), GHPO 355(SEQ ID NO: 281), GHPO 357 PO (SEQ ID NO: 283), GHPO 454(SEQ ID NO: 285), GHPO (475 ID NO: 287), GHPO515(SEQ ID NO: 289), GHPO 527(SEQ ID NO: 291), GHPO (SEQ ID NO: 293), GHPO293(SEQ ID NO: 293), GHPO 602(SEQ ID NO: 295), GHPO626(SEQ ID NO: 297), GHPO646(SEQ ID NO: 299), GHPO 653(SEQ ID NO: 301), GHPO 655(SEQ ID NO: 303), GHPO 670(SEQ ID NO: 305), GHPO739(SEQ ID NO: 307), GHPO798(SEQ ID NO: 309), GHPO 1102(SEQ ID NO: 311), GHPO 1114(SEQ ID NO: 313), GHPO 1152(SEQ ID NO: 315), GHPO 1272(SEQ ID NO: 317), GHPO 1345(SEQ ID NO: 319), GHPO 1377(SEQ ID NO: 321), GHPO 4(SEQ ID NO: 323), GHPO (1430 SEQ ID NO: 325), GHPO (SEQ ID NO: 1502), GHPO 1600(SEQ ID NO: 329), GHPO 171331), GHPO 359(SEQ ID NO: 359), GHPO 678(SEQ ID NO: 335), GHPO 708(SEQ ID NO: 337), GHPO 759(SEQ ID NO: 339), GHPO 847(SEQ ID NO: 341), GHPO 1050(SEQ ID NO: 343), GHPO 1101(SEQ ID NO: 345), GHPO 1120(SEQ ID NO: 347), GHPO 1138(SEQ ID NO: 349), GHPO 1310(SEQ ID NO: 351), GHPO 1320(SEQ ID NO: 353), GHPO 1375(SEQ ID NO: 355), GHPO 2(SEQ ID NO: 143357), GHPO21 (SEQ ID NO: 359), GHPO282(SEQ ID NO: 361), GHPO 1089(SEQ ID NO: 363), GHPO 1141(SEQ ID NO: 365), GHPO 1280(SEQ ID NO: 367), GHPO (SEQ ID NO: 1608: 369), GHPO15 (SEQ ID NO: 371), GHPO16(SEQ ID NO: 373), GHPO36 (SEQ ID NO: 375), GHPO38 (SEQ ID NO: 377), GHPO52 (SEQ ID NO: 379), GHPO57(SEQ ID NO: 381), GHPO64(SEQ ID NO: 383), GHPO79 (SEQ ID NO: 385), GHPO84 (SEQ ID NO: 387), GHPO86(SEQ ID NO: 389), GHPO99(SEQ ID NO: 391), GHPO106(SEQ ID NO: 393), GHPO 118(SEQ ID NO: 395), GHPO 122(SEQ ID NO: 397), GHPO128 (SEQ ID NO: 399), GHPO138(SEQ ID NO: 401), GHPO153(SEQ ID NO: 407), GHPO 160(SEQ ID NO: 405), GHPO 168(SEQ ID NO: 407), GHPO 179(SEQ ID NO: 409), GHPO189(SEQ ID NO: 411), GHPO229(SEQ ID NO: 413), GHPO (SEQ ID NO: 415), GHPO 244(SEQ ID NO: 417), GHPO (SEQ ID NO: 419), GHPO267(SEQ ID NO: 421), GHPO269(SEQ ID NO: 423), GHPO 279(SEQ ID NO: 425), GHPO 284(SEQ ID NO: 427), GHPO296 (SEQ ID NO: 429), GHPO300(SEQ ID NO: 431), GHPO305(SEQ ID NO: 433), GHPO 319(SEQ ID NO: 435), GHPO 330(SEQ ID NO: 437), GHPO 340(SEQ ID NO: 439), GHPO342(SEQ ID NO: 441), GHPO344(SEQ ID NO: 443), GHPO 358(SEQ ID NO: 445), GHPO 373(SEQ ID NO: 447), GHPO 382(SEQ ID NO: 449), GHPO384(SEQ ID NO: 451), GHPO398(SEQ ID NO: 453), GHPO (SEQ ID NO: 409), GHPO 422(SEQ ID NO: 457), GHPO 430(SEQ ID NO: 459), GHPO446(SEQ ID NO: 461), GHPO 463(SEQ ID NO: 463), GHPO 450(SEQ ID NO: 465), GHPO 451(SEQ ID NO: 467), GHPO 452(SEQ ID NO: 469), GHPO456(SEQ ID NO: 471), GHPO461(SEQ ID NO: 473), GHPO 476(SEQ ID NO: 475), GHPO 478(SEQ ID NO: 477), GHPO 491(SEQ ID NO: 479), GHPO511(SEQ ID NO: 481), GHPO519(SEQ ID NO: 483), GHPO 526(SEQ ID NO: 485), GHPO 534(SEQ ID NO: 487), GHPO 536(SEQ ID NO: 489), GHPO542(SEQ ID NO: 491), GHPO544(SEQ ID NO: 493), GHPO 576(SEQ ID NO: 495), GHPO (SEQ ID NO: 497), GHPO 580(SEQ ID NO: 499), GHPO (SEQ ID NO: 501), GHPO599(SEQ ID NO: 63503), GHPO 505: 642), GHPO 505(SEQ ID NO: 507), GHPO 647(SEQ ID NO: 509), GHPO654(SEQ ID NO: 511), GHPO669(SEQ ID NO: 513), GHPO 710(SEQ ID NO: 515), GHPO 713(SEQ ID NO: 517), GHPO 716(SEQ ID NO: 519), GHPO718(SEQ ID NO: 521), GHPO726(SEQ ID NO: 523), GHPO 734(SEQ ID NO: 525), GHPO 740(SEQ ID NO: 527), GHPO 770(SEQ ID NO: 529), GHPO782(SEQ ID NO: 531), GHPO786(SEQ ID NO: 533), GHPO 792(SEQ ID NO: 535), GHPO 797(SEQ ID NO: 537), GHPO 816(SEQ ID NO: 539), GHPO828(SEQ ID NO: 541), GHPO839(SEQ ID NO: 543), GHPO840 (SEQ ID NO: 545), GHPO 842(SEQ ID NO: 547), GHPO 885(SEQ ID NO: 549), GHPO 549), GHPO889(SEQ ID NO: 551), GH PO903(SEQ ID NO: 553), GHPO 912(SEQ ID NO: 555), GHPO 946(SEQ ID NO: 557), GHPO 958(SEQ ID NO: 559), GHPO968(SEQ ID NO: 561), GHPO987(SEQ ID NO: 563), GHPO 992(SEQ ID NO: 565), GHPO 996(SEQ ID NO: 567), GHPO 997(SEQ ID NO: 569), GHPO1002(SEQ ID NO: 571), GHPO 1026 PO (SEQ ID NO: 573), GHPO (SEQ ID NO: 575), GHPO 1034(SEQ ID NO: 577), GHPO 1038(SEQ ID NO: 579), GHPO 1059(SEQ ID NO: 581), GHPO 1065(SEQ ID NO: 583), GHPO 1072(SEQ ID NO: 585), GHPO 1073(SEQ ID NO: 587), GHPO 1088(SEQ ID NO: 1089), GHPO 1091(SEQ ID NO: 1091), GHPO 1105(SEQ ID NO: 593), GHPO 1115(SEQ ID NO: 595), GHPO 1159(SEQ ID NO: 597), GHPO 1177(SEQ ID NO: 599), GHPO 1187(SEQ ID NO: 601), GHPO 1192(SEQ ID NO: 603), GHPO 1195(SEQ ID NO: 605), GHPO 1224(SEQ ID NO: 607), GHPO 1225(SEQ ID NO: 609), GHPO 1228(SEQ ID NO: 611), GHPO 1229(SEQ ID NO: 613), GHPO 1231(SEQ ID NO: 615), GHPO 1236(SEQ ID NO: 617), GHPO 1242(SEQ ID NO: 619), GHPO 1248(SEQ ID NO: 621), GHPO 1270(SEQ ID NO: 623), GHPO 1271(SEQ ID NO: 625), GHPO 1298(SEQ ID NO: 627), GHPO 629627), GHPO (SEQ ID NO: 629) (SEQ ID NO: 631), GHPO 1304(SEQ ID NO: 631), GHPO 1315), GHPO 1319(SEQ ID NO: 635), GHPO 1323(SEQ ID NO: 637), GHPO 1331(SEQ ID NO: 639), GHPO 1332(SEQ ID NO: 641), GHPO 1347(SEQ ID NO: 643), GHPO 1373(SEQ ID NO: 645), GHPO 1376(SEQ ID NO: 647), GHPO 1380(SEQ ID NO: 649), GHPO 1394(SEQ ID NO: 651), GHPO 1407(SEQ ID NO: 653), GHPO 1415(SEQ ID NO: 655), GHPO 1425(SEQ ID NO: 657), GHPO 1427(SEQ ID NO: 659), GHPO 1444(SEQ ID NO: 144661), GHPO 9(SEQ ID NO: 663), GHPO 1465(SEQ ID NO: 665), GHPO 1475(SEQ ID NO: 667), GHPO 9(SEQ ID NO: 669), GHPO 1483(SEQ ID NO: 1483), GHPO 671478 (SEQ ID NO: 149675), GHPO 676), GHPO 1524(SEQ ID NO: 677), GHPO 1536(SEQ ID NO: 679), GHPO 1539(SEQ ID NO: 681), GHPO 1540(SEQ ID NO: 683), GHPO 1542(SEQ ID NO: 685), GHPO 1555(SEQ ID NO: 687), GHPO 1560(SEQ ID NO: 689), GHPO 1564(SEQ ID NO: 691), GHPO 1570(SEQ ID NO: 693), GHPO 1588(SEQ ID NO: 695), GHPO 1604(SEQ ID NO: 697), GHPO 1605(SEQ ID NO: 699), GHPO 1619(SEQ ID NO: 701), GHPO 1629(SEQ ID NO: 703), GHPO 1642(SEQ ID NO: 705), GHPO 1654(SEQ ID NO: 707), GHPO 1661(SEQ ID NO: 709), GHPO 3(SEQ ID NO: 711), GHPO 1687(SEQ ID NO: 713), GHPO 16892), GHPO 16993 (SEQ ID NO: 16993), GHPO 1699(SEQ ID NO: 719), GHPO 1738(SEQ ID NO: 721), GHPO 1745(SEQ ID NO: 723), GHPO 1746(SEQ ID NO: 725), GHPO 1754(SEQ ID NO: 727), GHPO 1792(SEQ ID NO: 729), GHPO 1795(SEQ ID NO: 731), GHPO 1796(SEQ ID NO: 733), GHPO 7(SEQ ID NO: 735), GHPO 8(SEQ ID NO: 737), GHPO 9(SEQ ID NO: 739), GHPO10 (SEQ ID NO: 741), GHPO12 (SEQ ID NO: 743), GHPO25(SEQ ID NO: 745), GHPO27 (SEQ ID NO: 747), GHPO29 (SEQ ID NO: 749), GHPO30 (SEQ ID NO: 751), GHPO 37(SEQ ID NO: 753), GHPO49(SEQ ID NO: 755), GHPO51(SEQ ID NO: 757), GHPO 759(SEQ ID NO: 759), GHPO65 (SEQ ID NO: 761), GHPO66 (SEQ ID NO: 763), GHPO68(SEQ ID NO: 765), GHPO70(SEQ ID NO: 767), GHPO 77(SEQ ID NO: 769), GHPO83 (SEQ ID NO: 771), GHPO85 (SEQ ID NO: 773), GHPO87(SEQ ID NO: 775), GHPO91(SEQ ID NO: 777), GHPO 92(SEQ ID NO: 779), GHPO96 (SEQ ID NO: 781), GHPO 97(SEQ ID NO: 783), GHPO111(SEQ ID NO: 785), GHPO115(SEQ ID NO: 787), GHPO117 (SEQ ID NO: 789), GHPO 123(SEQ ID NO: 791), GHPO 124(SEQ ID NO: 793), GHPO126(SEQ ID NO: 795), GHPO127(SEQ ID NO: 797), GHPO 123(SEQ ID NO: 799), GHPO 801 (SEQ ID NO: 793), GHPO 124(SEQ ID NO: 793), GHPO 133(SEQ ID NO: 803), GHPO140(SEQ ID NO: 805), GHPO141(SEQ ID NO: 807), GHPO 145(SEQ ID NO: 809), GHPO147 (SEQ ID NO: 811), GHPO 166(SEQ ID NO: 813), GHPO181(SEQ ID NO: 815), GHPO187 (SEQ ID NO: 817), GHPO 188(SEQ ID NO: 819), GHPO 192(SEQ ID NO: 821), GHPO 202(SEQ ID NO: 823), GHPO204(SEQ ID NO: 825), GHPO205(SEQ ID NO: 827), GHPO 212(SEQ ID NO: 829), GHPO 218(SEQ ID NO: 831), GHPO 226(SEQ ID NO: 833), GHPO231(SEQ ID NO: 835), GHPO236(SEQ ID NO: 837), GHPO 239(SEQ ID NO: 839), GHPO 245(SEQ ID NO: 841), GHPO (SEQ ID NO: 843), GHPO248(SEQ ID NO: 845), GHPO253(SEQ ID NO: 847), GHPO 265(SEQ ID NO: 849), GHPO 266(SEQ ID NO: 851), GHPO 271(SEQ ID NO: 853), GHPO272(SEQ ID NO: 855), GHPO286(SEQ ID NO: 857), GHPO 291(SEQ ID NO: 859), GHPO 292(SEQ ID NO: 861), GHPO 297(SEQ ID NO: 863), GHPO304(SEQ ID NO: 865), GHPO307(SEQ ID NO: 867), GHPO 324(SEQ ID NO: 869), GHPO 326(SEQ ID NO: 871), GHPO 331(SEQ ID NO: 873), GHPO343(SEQ ID NO: 875), GHPO345(SEQ ID NO: 877), GHPO 346(SEQ ID NO: 879), GHPO 352(SEQ ID NO: 881), GHPO 355(SEQ ID NO: 3), GHPO363(SEQ ID NO: 885), GHPO 88363 (SEQ ID NO: 887), GHPO 376(SEQ ID NO: 889), GHPO 378(SEQ ID NO: 891), GHPO 388(SEQ ID NO: 893), GHPO396(SEQ ID NO: 895), GHPO403(SEQ ID NO: 897), GHPO 410(SEQ ID NO: 899), GHPO 415(SEQ ID NO: 901), GHPO 421(SEQ ID NO: 903), GHPO439(SEQ ID NO: 905), GHPO441(SEQ ID NO: 907), GHPO 443(SEQ ID NO: 909), GHPO 453(SEQ ID NO: 911), GHPO 455(SEQ ID NO: 913), GHPO464(SEQ ID NO: 915), GHPO467(SEQ ID NO: 917), GHPO 468(SEQ ID NO: 919), GHPO 470(SEQ ID NO: 921), GHPO 486(SEQ ID NO: 923), GHPO487(SEQ ID NO: 925), GHPO488(SEQ ID NO: 927), GHPO 489(SEQ ID NO: 92498), GHPO (SEQ ID NO: 498), GHPO 501(SEQ ID NO: 933), GHPO504(SEQ ID NO: 935), GHPO512(SEQ ID NO: 937), GHPO 517(SEQ ID NO: 939), GHPO 520(SEQ ID NO: 941), GHPO 528(SEQ ID NO: 943), GHPO530(SEQ ID NO: 945), GHPO532(SEQ ID NO: 947), GHPO 548(SEQ ID NO: 949), GHPO 561(SEQ ID NO: 951), GHPO 564(SEQ ID NO: 953), GHPO572(SEQ ID NO: 955), GHPO573(SEQ ID NO: 957), GHPO 574(SEQ ID NO: 959), GHPO 577(SEQ ID NO: 961), GHPO 579(SEQ ID NO: 963), GHPO583(SEQ ID NO: 965), GHPO (SEQ ID NO: 967), GHPO 593(SEQ ID NO: 969), GHPO 597(SEQ ID NO: 5997598), GHPO 593(SEQ ID NO: 97598), GHPO604(SEQ ID NO: 975), GHPO606(SEQ ID NO: 977), GHPO 611(SEQ ID NO: 979), GHPO 612(SEQ ID NO: 981), GHPO615 (SEQ ID NO: 983), GHPO632(SEQ ID NO: 985), GHPO633(SEQ ID NO: 987), GHPO 637(SEQ ID NO: 989), GHPO 651(SEQ ID NO: 991), GHPO 663(SEQ ID NO: 993), GHPO686(SEQ ID NO: 995), GHPO693(SEQ ID NO: 997), GHPO 698(SEQ ID NO: 999), GHPO 703(SEQ ID NO: 1001), GHPO (SEQ ID NO: 1003), GHPO 705(SEQ ID NO: 1005), GHPO (SEQ ID NO: 707), GHPO (SEQ ID NO: 721), GHPO (SEQ ID NO: 733), GHPO 727(SEQ ID NO: 1011), GHPO (SEQ ID NO: 728), GHPO 728: 728) (SEQ ID NO: 1015), GHPO 758(SEQ ID NO: 1017), GHPO 763(SEQ ID NO: 1019), GHPO 771(SEQ ID NO: 1021), GHPO 774(SEQ ID NO: 1023), GHPO 776(SEQ ID NO: 1025), GHPO 783(SEQ ID NO: 1027), GHPO 800(SEQ ID NO: 1029), GHPO 806(SEQ ID NO: 1031), GHPO 807(SEQ ID NO: 1033), GHPO 808(SEQ ID NO: 1035), GHPO 809(SEQ ID NO: 1037), GHPO 811(SEQ ID NO: 1039), GHPO 815(SEQ ID NO: 1041), GHPO 819(SEQ ID NO: 1043), GHPO 841(SEQ ID NO: 1045), GHPO 843(SEQ ID NO: 1047), GHPO 846(SEQ ID NO: 1049), GHPO (SEQ ID NO: 105875), GHPO 892(SEQ ID NO: 1051), GHPO 892(SEQ ID NO: 1053), GHPO 902(SEQ ID NO: 904), GHPO 906(SEQ ID NO: 1059), GHPO 908(SEQ ID NO: 1061), GHPO 921(SEQ ID NO: 1063), GHPO 923(SEQ ID NO: 1065), GHPO 926(SEQ ID NO: 1067), GHPO 933(SEQ ID NO: 1069), GHPO 939(SEQ ID NO: 1071), GHPO 940(SEQ ID NO: 1073), GHPO 943(SEQ ID NO: 1075), GHPO 951(SEQ ID NO: 1077), GHPO961 (SEQ ID NO: 1079), GHPO 965(SEQ ID NO: 1081), GHPO 990(SEQ ID NO: 1083), GHPO 991(SEQ ID NO: 1085), GHPO 998(SEQ ID NO: 1087), GHPO 1001(SEQ ID NO: 1089), GHPO 1005(SEQ ID NO: 1005 1), GHPO1033(SEQ ID NO: 1093), GHPO1039 (SEQ ID NO: 1035), GHPO 1001(SEQ ID NO: 1093), GHPO 1093 (SEQ ID NO: 1091093), GHPO 1044(SEQ ID NO: 1101), GHPO 1051(SEQ ID NO: 1103), GHPO 1058(SEQ ID NO: 1105), GHPO 1060(SEQ ID NO: 1107), GHPO 1075(SEQ ID NO: 1109), GHPO1077(SEQ ID NO: 1111), GHPO1082(SEQ ID NO: 1113), GHPO 1083(SEQ ID NO: 1115), GHPO 1086(SEQ ID NO: 1117), GHPO 1087(SEQ ID NO: 1119), GHPO 1090(SEQ ID NO: 1121), GHPO 1097(SEQ ID NO: 1123), GHPO 1098(SEQ ID NO: 1125), GHPO 1103(SEQ ID NO: 1127), GHPO1113(SEQ ID NO: 1129), GHPO (SEQ ID NO: 1131), GHPO 1121123 (SEQ ID NO: 1133), GHPO 1125(SEQ ID NO: 1135), GHPO 1129(SEQ ID NO: 1131137), GHPO (SEQ ID NO: 1130: 1144), GHPO 4(SEQ ID NO: 1143), GHPO 1161(SEQ ID NO: 1143), GHPO 1166(SEQ ID NO: 1145), GHPO1170(SEQ ID NO: 1147), GHPO1175(SEQ ID NO: 1149), GHPO 1181(SEQ ID NO: 1151), GHPO 1186(SEQ ID NO: 1153), GHPO 1188(SEQ ID NO: 1155), GHPO 1191(SEQ ID NO: 1157), GHPO 1193(SEQ ID NO: 1159), GHPO 1196(SEQ ID NO: 1161), GHPO 1204(SEQ ID NO: 1163), GHPO1210(SEQ ID NO: 1165), GHPO1211(SEQ ID NO: 1167), GHPO 1216(SEQ ID NO: 1169), GHPO 1218(SEQ ID NO: 1171), GHPO 1220(SEQ ID NO: 1173), GHPO 1223(SEQ ID NO: 1175), GHPO 1226(SEQ ID NO: 1177), GHPO (SEQ ID NO: 1241240), GHPO 1220(SEQ ID NO: 1181), GHPO 1181(SEQ ID NO: 1183), GHPO1252(SEQ ID NO: 1185), GHPO 1261(SEQ ID NO: 1187), GHPO 1265(SEQ ID NO: 1189), GHPO 1267(SEQ ID NO: 1191), GHPO 1278(SEQ ID NO: 1193), GHPO1282 (SEQ ID NO: 1195), GHPO 1283(SEQ ID NO: 1197), GHPO 1287(SEQ ID NO: 1199), GHPO1292(SEQ ID NO: 1201), GHPO1293(SEQ ID NO: 1203), GHPO 1302(SEQ ID NO: 1205), GHPO 1309(SEQ ID NO: 1207), GHPO 1317(SEQ ID NO: 1209), GHPO 1318(SEQ ID NO: 1211), GHPO 1321(SEQ ID NO: 1213), GHPO 1325(SEQ ID NO: 1215), GHPO 1341(SEQ ID NO: 1217), GHPO 1351211 (SEQ ID NO: 1221219), GHPO 1351351214 (SEQ ID NO: 1351364), GHPO 1373(SEQ ID NO: 1373), GHPO 1371(SEQ ID NO: 1375), GHPO 1381(SEQ ID NO: 1227), GHPO 1401(SEQ ID NO: 1229), GHPO 1402(SEQ ID NO: 1231), GHPO 1403(SEQ ID NO: 1233), GHPO 1408(SEQ ID NO: 1235), GHPO1416(SEQ ID NO: 1237), GHPO1420(SEQ ID NO: 1239), GHPO 1428(SEQ ID NO: 1241), GHPO 1437(SEQID NO: 1243), GHPO 1439(SEQ ID NO: 1245), GHPO 1460(SEQ ID NO: 1247), GHPO 1463(SEQ ID NO: 1249), GHPO 1472(SEQ ID NO: 1251), GHPO 1474(SEQ ID NO: 1253), GHPO1484(SEQ ID NO: 1255), GHPO 9(SEQ ID NO: 1257), GHPO 1254 (SEQ ID NO: 1259), GHPO 1495(SEQ ID NO: 1491), GHPO 1268 (SEQ ID NO: 1263), GHPO 1495(SEQ ID NO: 1499), GHPO 1499(SEQ ID NO: 1499), GHPO 1503(SEQ ID NO: 1269), GHPO 1504(SEQ ID NO: 1271), GHPO1510(SEQ ID NO: 1273), GHPO1518(SEQ ID NO: 1275), GHPO 1533(SEQ ID NO: 1277), GHPO 1541(SEQ ID NO: 1279), GHPO 1544(SEQ ID NO: 1281), GHPO 1548(SEQ ID NO: 1283), GHPO 1565(SEQ ID NO: 1285), GHPO 1575(SEQ ID NO: 1287), GHPO 1582(SEQ ID NO: 1289), GHPO1595(SEQ ID NO: 1291), GHPO1597(SEQ ID NO: 1293), GHPO 1599(SEQ ID NO: 1295), GHPO 1601(SEQ ID NO: 1297), GHPO 1609(SEQ ID NO: 1299), GHPO 1633 (SEQ ID NO: 1631301), GHPO 1614(SEQ ID NO: 1303), GHPO 6(SEQ ID NO: 1628), GHPO 1309(SEQ ID NO: 1629), GHPO 1309(SEQ ID NO: 1309), GHPO1640(SEQ ID NO: 1311), GHPO 1641(SEQ ID NO: 1313), GHPO 1646(SEQ ID NO: 1315), GHPO 1662(SEQ ID NO: 1317), GHPO 1667(SEQ ID NO: 1319), GHPO 1668(SEQ ID NO: 1321), GHPO 1670(SEQ ID NO: 1323), GHPO 1671(SEQ ID NO: 1325), GHPO1672(SEQ ID NO: 1327), GHPO1678 (SEQ ID NO: 1329), GHPO 1684(SEQ ID NO: 1331), GHPO 95(SEQ ID NO: 1699), GHPO 1697(SEQ ID NO: 1331335), GHPO 1701(SEQ ID NO: 1347), GHPO1719(SEQ ID NO: 1339), GHPO 1723(SEQ ID NO: 1341), GHPO 2(SEQ ID NO: 1343), GHPO 1341349), GHPO 1731349 (SEQ ID NO: 1349), GHPO 1341349 (SEQ ID NO: 1341), GHPO 1347), GHPO 1349 (SEQ ID NO: 1349), GHPO 1341(SEQ ID NO: 1351351), GHPO 1750(SEQ ID NO: 1353), GHPO 1751(SEQ ID NO: 1355), GHPO 1755(SEQ ID NO: 1357), GHPO 1771(SEQ ID NO: 1359), GHPO 1786(SEQ ID NO: 1361), and GHPO1789(SEQ ID NO: 1363).
An isolated polynucleotide of the invention encodes (i) a polypeptide having an amino acid sequence homologous to a helicobacter amino acid sequence selected from the group consisting of the amino acid sequences shown in the sequence listing (even numbered, up to sequence 1364), or (ii)a derivative of said polypeptide.
In addition to the full length polypeptides encoded by the polynucleotides of the invention described above, the polynucleotides encompassed by the invention may encode polypeptides lacking a signal sequence, as well as other polypeptides or peptide fragments of the full length polypeptides.
The term "isolated polypeptide" is defined as a polypeptide that is removed from its naturally occurring environment. For example, a naturally occurring DNA molecule that is present in the genome of a living bacterium or is part of a gene pool is not isolated, but is "isolated" after the same molecule is separated from the rest of the bacterial genome, for example, by a cloning process (amplification). Typically, an isolated DNA molecule does not contain a DNA segment (e.g., a coding region) adjacent to its 5 'or 3' end in a naturally occurring genome. The isolated polynucleotide may be part of a vector or composition, but is still isolated in that the vector or composition is not part of its natural environment.
Polynucleotides of the invention may comprise RNA or DNA (e.g., cDNA, genomic DNA, or synthetic DNA), or modifications or combinations of RNA or DNA. The polynucleotide may be double-stranded or single-stranded, and if single-stranded, may be the coding (sense) strand or the noncoding (antisense) strand. The sequence encoding a polypeptide of the invention (even, up to sequence 1364) as shown in the sequence listing may be (a) a coding sequence (odd, up to sequence 1363) as shown in any of the nucleotide sequences in the sequence listing; (b) a ribonucleotide sequence produced by transcription of (a); or (c) a different coding sequence which results from the redundancy or degeneracy of the genetic code and which encodes a polypeptide which is identical to the polypeptide encoded by a polynucleotide molecule having any one of the nucleotide sequences set forthin the sequence listing (odd numbers up to sequence 1363). The polypeptide may be a polypeptide naturally secreted or secreted by a bacterium such as helicobacter felis, helicobacter ferret, helicobacter marini or helicobacter pylori.
"polypeptide" or "protein" refers to any chain of amino acids, regardless of their length or post-translational modifications (e.g., glycosylation or phosphorylation). These two terms may be used interchangeably in this application.
"homologous amino acid sequence" means an amino acid sequence which differs from the amino acid sequence shown in the sequence Listing (even-numbered up to sequence 1364) or the amino acid sequence encoded by the nucleotide sequence shown in the sequence Listing (odd-numbered up to sequence 1363) by one or more non-conservative amino acid substitutions, deletions, or additions, which occur at positions which do not destroy the specific antigenicity of the polypeptide. Preferably, the sequence has at least 75%, more preferably at least 80%, and most preferably at least 90% homology to the amino acid sequence depicted in the sequence listing (even-numbered up to sequence 1364). Homologous amino acid sequences include sequences which are identical or substantially identical to the amino acid sequences shown in the sequence listing (even numbers up to sequence 1364). By "substantially identical amino acid sequence" is meant a sequence that is at least 90%, preferably at least 95%, more preferably at least 97%, and most preferably at least 99% homologous to a reference amino acid sequence, and differs from the reference sequence, if at all, primarily by conservative amino acid substitutions.
Conservative amino acid substitutions generally include substitutions between amino acids of the same type, including those with uncharged polar side chains, such as asparagine, glutamine, serine, threonine, and tyrosine; amino acids having basic side chains such as lysine, arginine, and histidine, amino acids having acidic side chains such as aspartic acid and glutamic acid; and amino acids having nonpolar side chains, such as glycine, alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan, and cysteine.
Homology can be determined using sequence analysis software (e.g., the sequence analysis software package of the genetics computer group, University of Wisconsin Biotechnology center, 1810University Avenue, Madison WI 93808). Similar amino acid sequences are compared in order to obtain the greatest degree of homology (i.e., identity). To this end, it is necessary to artificially introduce gaps into the sequence, and once the optimal alignment is established, the degree of homology (i.e., identity) is determined by recording the ratio of all sites of amino acid identity between the two sequences relative to the total number of sites.
Homologous polynucleotide sequences are defined in a similar manner. Preferably, the homology of the homologous sequence is at least 45%, more preferably at least 60%, most preferably at least 85% to the coding sequence of the nucleotide sequence depicted in the sequence listing (odd numbered up to sequence 1363).
Polypeptides having sequences homologous to any of the sequences shown in the sequence listing (even-numbered up to sequence 1364) include naturally occurring allelic variants, as well as mutants or any other non-naturally occurring variants, which are antigenically similar to polypeptides having sequences shown in the sequence listing (even-numbered up to sequence 1364).
As is well known in the art, an allelic variant is an alternative form of a polypeptide, and is characterized by substitution, deletion, or addition of one or more amino acids that do not alter the biological function of the polypeptide. "biological function" refers to the function of the polypeptide in its naturally occurring cell, even if the function is not required for the growth or survival of the cell. For example, the biological function of porins is to allow compounds present in the extracellular matrix to enter the cell. The cytological function is different from the antigenic function. A polypeptide may have more than one biological function.
Allelic variants are quite common in nature. For example, bacterial species such as helicobacter pylori are often strains that exhibit only minor allelic variation between each other. In fact, polypeptides that satisfy the same biological function in different strains differ in their amino acid sequence in each strain. The allelic variation described above may also be present at the polynucleotide level.
Support for the use of allelic variants of polypeptide antigens comes from studies such as helicobacter urease antigens. The amino acid sequence of helicobacter urease varies widely between species, however cross-species protection also occurs, indicating that the urease molecule is highly tolerant of amino acid variation when used as an immunogen. Variations in amino acid sequence exist even between different strains of the same helicobacter pylori species.
For example, although the amino acid sequences of the UreA and UreB subunits of H.pylori and H.felis differ by 26.5% and 11.8%, respectively (Ferero et al, molecular microbiology 9 (2): 323-Busch 333, 1993), it has been demonstrated that H.pylori urease protects mice from infection by H.felis (Michetti et al, gastroenterology 107: 1002, 1994). In addition, it has been demonstrated that the independent urease structural subunits containing different amino acid sequences, UreA and UreB, are protective antigens against helicobacter infection (Michetti et al, supra). Similarly, Cuenca et al (gastroenterology 110: 1770, 1996) demonstrated that therapeutic vaccination of helicobacter pylori urease in ferrets with helicobacter pylori is effective in eradicating helicobacter ferret infection. In addition, several urease variants have been reported to be effective vaccine antigens, including, for example, recombinant UreA + UreB dehycocoenzyme expressed by pORV142 (UreA and UreB sequences are derived from the H.pylori strain CPM 630; Lee et al, J.InfectionSci 172: 161, 1995); recombinant UreA + UreB dehycocoenzyme expressed by pORV214 (the UreA and UreB sequences differ from the H.pylori strain CPM630 by one and two amino acids, respectively; Lee et al, supra, 1995); UreA glutathione-S-transferase fusion protein (UreA sequence from helicobacter pylori ATCC 43504; Thomas et al, Acta Gastro-Enterologica Belgica 56: 54, 1993); UreA + UreB holoenzyme purified from the H.pylori strain NCTC11637 (Marchetti et al, science 267: 1655, 1995); UreA-MBP fusion protein (UreA from H.pylori strain 85P; Ferero et al, infection and immunization 62: 4981, 1994); UreB-MBP fusion protein (UreB from H.pylori strain 85P; Michetti et al, supra); UreA-MBP fusion protein (UreA from the helicobacter felis strain ATCC 49179; Michetti et al, supra); UreB-MBP fusion protein (UreB from the H.felis strain ATCC 49179; Michetti et al, supra); and a 37kDa UreB fragment containing amino acids 220-569 (Dore-Davin et al, "37 kDa UreB fragment is sufficient to confer protection to mice against helicobacter felis infection"). Finally, Thomas et al (supra) demonstrated that oral vaccination of mice with crude sonicate of helicobacter can confer protection to mice when subsequently challenged with helicobacter felis.
Polynucleotides, e.g., DNA molecules, encoding allelic variants can be conveniently obtained by Polymerase Chain Reaction (PCR) amplification of genomic bacterial DNA isolated by conventional methods. The method involves the use of synthetic oligonucleotide primers that match the upstream and downstream sequences of the 5 'and 3' ends of the coding region. Suitable primers can be designed based on the nucleotide sequence information provided in the sequence listing (odd numbers up to sequence 1363). Typically, a primer comprises 10-40, preferably 15-25 nucleotides. Preferably, the C and G nucleotides are present in a proportion sufficient to ensure effective hybridization of the primer, e.g., the C and G nucleotides are present in an amount of at least 40%, at least 50% of the total nucleotides. One skilled in the art can readily design primers for extracting the polynucleotides of the present invention from different helicobacter strains. The experimental conditions for performing PCR can be easily determined by those skilled in the art, and the method for performing PCR is illustrated in example 2. As is known in the art, a restriction endonuclease recognition site may be included at the 5 ' end of the primer, which site typically comprises 4-6 nucleotides (the sequence 5 ' -GGATCC-3 ' (BamHI) or 5 ' -CTCGAG-3 ' (XhoI)). Restriction sites may be selected by those skilled in the art so that the amplified DNA may be conveniently cloned into an appropriately digested vector such as a plasmid.
Useful homologues not found in nature can be designed by known methods to identify fragments of the antigen that are likely to tolerate amino acid sequence changes and/or deletions. For example, antigen sequences from different species may be compared in order to identify conserved sequences.
Polypeptide derivatives encoded by the polynucleotides of the invention include, for example, fragments, polypeptides with large internal deletions derived from full-length polypeptides and fusion proteins. The polypeptide fragments of the present invention may be derived from polypeptides having a sequence homologous to any one of the sequences in the sequence listing (even numbered up to sequence 1364) to such an extent that the fragment substantially retains the antigenicity (specific antigenicity) of its parent polypeptide. Polypeptide derivatives may also be constructed by large internal deletions which remove a substantial portion of the parent polypeptide, but retain specific antigenicity. In general, the polypeptide derivative should be about at least 12 amino acids in length in order to retain antigenicity. Advantageously, it may be at least 20 amino acids in length, preferably at least 50 amino acids, more preferably at least 75 amino acids, most preferably at least 100 amino acids.
To identify sites in protein antigens with potential for exposure to surface antigen regions, computer-assisted amino acid sequence analysis can be used to design useful polypeptide derivatives such as polypeptide fragments (Hughes et al, infection immunology 60 (9): 3497, 1992). For example, the hydrophilicity, antigenic index, and intensity index profiles of the polypeptide of the present invention can be obtained using the Laser Gene Program of DNA Star. The program can also be used to obtain information about the homology of the polypeptide to known protein motifs. The skilled person can conveniently screen for peptide fragments for use as vaccine antigens using the information provided in the curves. For example, one can screen for fragments that span the interval of the curve, others having a higher antigenic index. One can also screen fragments spanning regions where both the antigenic index and intensity curves are high. Fragments containing conserved sequences, particularly hydrophilic conserved sequences, may also be screened.
Large polypeptide fragments and polypeptides with internal deletions can also be used to reveal epitopes masked in the parent polypeptide, and which epitopes are important for inducing protective T cell-dependent immune responses. Deletions also eliminate highly variable dominant regions between strains.
It is feasible in the immunological arts to use fragments and variantsof protein immunogens as vaccines, since all that is required to induce an immune response to a protein is a small (e.g., 8-10 amino acid) immunogenic region of the protein. This approach has been applied to a variety of vaccines against pathogens other than helicobacter. For example, short synthetic peptides corresponding to exposed surface antigens of pathogens such as murine mammary carcinoma virus (11 amino acid containing peptides; Dion et al, virology 179: 474-.
Polynucleotides encoding polypeptide fragments and polypeptides with large internal deletions can be constructed using standard methods (see, e.g., Ausubel et al, methods of modern molecular biology, John Wiley&Sons, 1994), e.g., by PCR, including inverse PCR, by restriction enzyme treatment of cloned DNA molecules, or by the method of Kunkel et al (Proc. Natl. Acad. Sci. USA 82: 448, 1985; biomaterials supplied by Stratagene).
Polypeptide derivatives may also be produced in the form of fusion polypeptides comprising a polypeptide or polypeptide derivative of the invention, for example, fused at its N-or C-terminus to any other polypeptide (hereinafter referred to as a peptide tail). Such a product can be conveniently obtained by translation of a genetic fusion, i.e., a hybrid gene. Vectors for expression of fusion polypeptides are commercially available, including the pMal-c2 or pMal-p2 system of the New England Biolabs, in which the peptide tail is a maltose binding protein, the glutathione-S-transferase system of Pharmacia or the His-Tag system supplied by Novagen. The above and other expression systems provide convenient means for further purification of the polypeptides and derivatives of the invention.
Another specific example of a fusion polypeptide encompassed by the present invention includes a polypeptide or polypeptide derivative of the present invention fused to a polypeptide having adjuvant activity, such as the B subunit of cholera toxin or the heat-labile toxin of E.coli. Several possibilities can be used for the production of the fusion protein. First, the polypeptide of the present invention may be fused to the N-terminus or preferably the C-terminus of a polypeptide having adjuvant activity. Second, the polypeptide fragment of the present invention may be fused in the amino acid sequence of the polypeptide having adjuvant activity. A spacer sequence may also be included if desired.
As noted above, the polynucleotides of the invention encode a helicobacter polypeptide in its precursor or mature form. It may also encode hybrid precursors comprising heterologous signal peptides, which precursors can be matured into the polypeptides of the invention. "heterologous signal peptide" refers to a signal peptide not found in a naturally occurring precursor of a polypeptide of the invention.
The polynucleotide of the invention preferably hybridizes under stringent conditions to a polynucleotide having a sequence as shown in the sequence listing (odd numbered up to sequence 1363). Hybridization methods are disclosed in, for example, Ausubel et al (supra); silhavy et al (Gene fusion experiments, Cold spring harbor laboratory Press, Cold spring harbor, New York, 1984); davis et al (A Manual of genetic engineering: recent bacterial genetics, Cold spring harbor laboratory Press, Cold spring harbor, New York, 1980). Important parameters to be considered for optimizing hybridization conditions are represented in the following equation, which allows the calculation of the melting temperature (Tm) above which two complementary DNA strands separate from each other (Casey et al, nucleic acids research 4: 1539, 1977): tm, etc. ═ 81.5+0.5 × (% G + C) +1.6log (cation concentration) -0.6 × (% formamide). Under appropriately stringent conditions, the hybridization temperature (Th) is about 20-40 deg.C, 20-25 deg.C, or preferably 30-40 deg.C lower than the calculatedTm. It will be appreciated by those skilled in the art that the optimum temperature and stringent conditions may be readily determined empirically by preliminary experiments using routine methods. For example, stringent conditions can be achieved for prehybridization and hybridization incubations for (i) 4-16 hours at 42 ℃ in 6 XSSC containing 50% formamide or (ii) 4-16 hours at 65 ℃ in 6 XSSC aqueous solution (1M sodium chloride, 0.1M sodium citrate (pH 7.0)). For polynucleotides containing 30-600 nucleotides, the above formula is used, and then corrected by subtraction (600/polynucleotide size in base pairs). Stringent conditions are defined as Th 5-10 ℃ below Tm.
Hybridization conditions for oligonucleotides shorter than 20-30 bases do not follow the above rules precisely. In this case, the formula for calculating Tm is as follows: tm is 4 × (G + C) +2(a + T). For example, a fragment of 18 nucleotides with 50% G + C has a Tm of approximately 54 ℃.
Polynucleotide molecules, including RNA, DNA, or modified combinations thereof, can have a variety of uses. For example, polynucleotide molecules can be used (i) in recombinant host systems for the production of encoded polypeptides, (ii) to construct vaccine vectors such as poxviruses, which can be further used in methods and compositions for the prevention and/or treatment of helicobacter infection, (iii) as vaccine formulations, either in naked form or in combination with a delivery vector, and (iv) to construct attenuated helicobacter strains that can overexpress the polynucleotides of the invention or that are expressed in avirulent, mutated forms.
Thus, according to a second aspect of the invention, there is provided (i) an expression cassette comprising a polynucleotide molecule of the invention under the control of an element required for expression (e.g. a promoter); (ii) an expression vector comprising the expression cassette of the invention; (iii) (iii) a prokaryotic or eukaryotic cell transformed or transfected with an expression cassette and/or a vector of the invention, and (iv) a method for producing a polypeptide or polypeptide derivative encoded by a polynucleotide of the invention, which method comprises culturing a prokaryotic or eukaryotic cell transformed or transfected with an expression cassette and/or a vector of the invention under conditions such that a polynucleotide molecule of the invention is expressed, and recovering the encoded polypeptide or polypeptide derivative from the cell culture.
Recombinant expression systems can be selected from prokaryotic and eukaryotic hosts. For example, eukaryotic hosts include yeast cells (e.g., Saccharomyces cerevisiae or Pichia pastoris), mammalian cells (e.g., COS1, NIH3T3 or JEG3 cells), arthropod cells (e.g., Spodoptera frugiperda (SF9) cells), and plant cells. Preferably, prokaryotic hosts such as E.coli are used. Bacterial and eukaryotic cells can be obtained from a variety of different sources well known to those skilled in the art, for example, the American type culture Collection (ATCC; Rockville, Md.).
The choice of expression cassette depends on the host system chosen, as well as the desired characteristics of the expressed polypeptide. For example, it may be used to produce a particular lipidated form or any other form of the polypeptide of the invention. Typically, an expression cassette includes a constitutive or inducible promoter capable of functioning in a particular host system; a ribosome binding site; an initiation codon (ATG); if necessary, a fragment encoding a signal peptide, e.g., a lipidation signal peptide; a polynucleotide molecule of the invention; a stop codon; and optionally a 3' terminal region (translation and/or transcription terminator). The signal peptide coding region is contiguous with and in correct reading frame with the polynucleotide of the present invention. The signal peptide coding region may be homologous or heterologous to the polynucleotide molecule encoding the mature polypeptide and may be specific for the secretion apparatus of the host used for expression. The open reading frame consisting of the polynucleotide molecule of the invention alone or together with a signal peptide is under the control of a promoter for transcription and translation in the host system. Promoters and signal peptide coding regions are well known and available to those skilled in the art, for example, include promoters (and derivatives) of Salmonella typhimurium which are inducible by arabinose (promoter araB) and which function in gram-negative bacteria such as E.coli (US5,028,530; Cagnon et al, protein engineering 4 (7): 843, 1991); the promoter of the bacteriophage T7RNA polymerase gene, which is capable of functioning in a variety of E.coli strains expressing T7 polymerase (U.S. Pat. No. 4,952,496); OspA lipidation signal peptide; and the RlpB lipidation signal peptide (Takase et al, J.Bacteriol 169: 5692, 1987).
The expression cassette is typically part of an expression vector, the choice of which depends on its ability to replicate in a particular expression system. For example, the expression vector (e.g., a plasmid or viral vector) can be selected from the vectors disclosed by Pouwels et al (cloning vectors: A laboratory Manual, 1985, supplementations 1987), and can be purchased from various commercial sources. Methods for transforming or transfecting host cells with expression vectors are well known in the art and depend on the host system chosen, as disclosed in Ausubel et al, supra.
Upon expression, the recombinant polypeptide (or polypeptide) of the invention is produced and retained in a cellular compartment, secreted/secreted into the extracellular medium or periplasmic space, or buried in the cell membrane. After centrifugation of the cell culture, the polypeptide can be recovered from the cell extract or supernatant in a substantially purified form. In general, the recombinant polypeptide may be purified by antibody-based affinity purification or by any other method known to those skilled in the art, such as by genetic fusion with a small affinity-binding domain. Antibody-based affinity purification methods may also be used to purify the polypeptides of the invention isolated from helicobacter strains. Antibodies for immunoaffinity purification of the polypeptides of the invention can be obtained by the following methods.
The polynucleotides of the invention may also be used in DNA vaccination methods using viral or bacterial hosts as gene delivery vectors (live vaccine vectors) or administering genes in free form, e.g. inserted into plasmids. The therapeutic or prophylactic efficacy of the polynucleotides of the present invention can be evaluated as follows.
Thus, in a third aspect of the invention, there is provided (i) a vaccine vector, such as a poxvirus, comprising a polynucleotide molecule of the invention under the control of a factor required for expression; (ii) a composition comprising a vaccine vector of the invention and a diluent or carrier; (iii) a pharmaceutical composition comprising a therapeutically or prophylactically effective amount of a vaccine carrier of the present invention; (iv) a method for inducing an immune response to helicobacter in a mammal (e.g., a human; or for use in veterinary applications for treating or preventing helicobacter infection in an animal, such as a cat or bird), comprising administering to said mammal an immunologically effective amount of a vaccine vector of the present invention so as to induce an immune response, e.g., a prophylactic or therapeutic immune response to helicobacter; and (v) a method of preventing and/or treating helicobacter (e.g., helicobacter pylori, helicobacter feline, helicobacter ferret, or helicobacter marini) infection, comprising administering to a subject in need thereof a prophylactic or therapeutic amount of a vaccine vector of the present invention. In addition, a third aspect of the invention comprises the use of a vaccine vector of the invention for the manufacture of a medicament for the prevention and/or treatment of helicobacter infection.
The vaccine vectors of the invention may express one or more polypeptides or derivatives of the invention, as well as at least one other helicobacter antigen, such as urease dehyrocoenzyme or a subunit, fragment, homologue, mutant, or derivative thereof. Alternatively, it may express a cytokine which enhances the immune response, such as interleukin-2 (IL-2) or interleukin-12 (IL-12). Thus, the vaccine vector may comprise an additional polynucleotide molecule encoding, for example, the A, B subunit of urease, or both, or a cytokine, under the control of factors required for expression in mammalian cells.
In addition, the composition of the invention may include several vaccine vectors, each capable of expressing one polypeptide or derivative of the invention. The compositions may also contain vaccine vectors capable of expressing other helicobacter antigens, such as urease dehyrocoenzymes, subunits, fragments, homologs, mutants, or derivatives thereof, or cytokines such as IL-2 or IL-12.
In an immunization method for treating or preventing infection in a mammal, the vaccine carrier of the present invention may be administered by any conventional route employed in the vaccine art, for example, for mucosal (e.g., ocular, nasal, oral, gastric, pulmonary, intestinal, rectal, vaginal, or urethral mucosa) surfaces, or by parenteral (e.g., subcutaneous, intradermal, intramuscular, intravenous, or intraperitoneal) routes. The preferred route depends on the choice of vaccine vector. The administration can be effected in a single dose or in repeated dosage forms used at intervals. The appropriate dosage will depend on various parameters known to those skilled in the art, such as the nature of the vaccine vector itself, the route of administration, and the condition of the mammal to be vaccinated (e.g., the weight, age, and general health of the mammal).
Live vaccine vectors useful in the present invention include viral vectors, such as adenoviruses and poxviruses, and bacterial vectors, such as shigella, salmonella, vibrio cholerae, lactobacillus, bacillus calmette-guerin (BCG), and streptococcus. Adenovirus vectorsExamples of such vectors and methods for constructing adenoviral vectors capable of expressing polynucleotide molecules of the invention are disclosed in US4,920,209. For example, poxvirus vectors useful in the present invention include vaccinia and canarypox viruses, which are disclosed in U.S. Pat. Nos. 4,722,848 and 5,364,773, respectively (see, e.g., Tartaglia et al, virology 188: 217, 1992 for descriptions of vaccinia virus vectors, and canarypox virus vectors, see Taylor et al, vaccine 13: 539, 1995). Vaccinia vectors capable of expressing the polynucleotides of the invention may also be obtained by homologous recombination, such as Kieny et al, (Nature 312: 163, 1984), to insert the polynucleotides of the invention into the viral genome under appropriate conditions for expression in mammalian cells. The dose of viral vector vaccine generally used for therapy or prophylaxis may be about 1X 104About 1X 1011Advantageously about 1X 107About 1X 1010Or preferably about 1X 107About 1X 109Plaque forming units/kg. Preferably, the viral vector is administered parenterally, e.g., in 3 doses at 4 week intervals. The state of the artIt will be appreciated by those skilled in the art that the addition of chemical adjuvants to compositions containing the viral vectors of the present invention is preferably avoided in order to reduce the immune response to the viral vector itself.
Non-toxigenic vibrio cholerae mutant strains that can be used in live oral vaccines are disclosed in the following references: mekalanos et al (Nature 306: 551, 1983), U.S. Pat. No. 4,882,278 (in this strain a major part of the coding sequence of each of the two ctxA alleles has been deleted and, therefore, cannot produce a functional cholera toxin); WO92/11354 (in this strain the irgA locus is inactivated by mutation; this mutation can be incorporated in the same strain with the ctxA mutation); and WO94/1533 (deletion mutant lacking functional ctxA and attRS1DNA sequences). The above strains may be genetically engineered to express heterologous antigens as disclosed in WO 94/19482. A vaccine effective amount of a Vibrio cholerae strain capable of expressing a polypeptide or polypeptide derivative encoded by a polynucleotide molecule of the invention may be in a composition comprising, for example, about 1X 105About 1X 109Preference is given toAbout 1X 106About 1X 108Live bacteria contained in a volume appropriate for a particular route of administration. Preferred routes of administration include all mucosal routes, however, it is most preferred to administer these carriers via nasal or oral cavity.
Nakayama et al (Bio/technology 6: 693, 1988) and WO92/11361 disclose attenuated strains of Salmonella typhimurium produced by genetic engineering methods for the recombinant expression of heterologous antigens and their use as oral vaccines. Preferred routes of administration of the carrier include all mucosal routes. Most preferably, these carriers are administered nasally or orally.
Other bacteria that can be used as vaccine vectors are disclosed in the following documents: high et al (EMBO 11: 1991, 1992) and Sizemore et al (science 270: 299, 1995; Shigella flexneri); medaglini et al (Proc. Natl. Acad. Sci. USA 92: 6868, 1995; Streptococcus grisea (Streptococcus gordonii));flynn (cell molecular biology 40 (supplement I): 31, 1194), and WO88/6626, WO90/0594, WO91/13157, WO92/1796, and WO92/21376 (BCG). In bacterial vectors, the polynucleotides of the invention may be inserted into the genome of the bacterium, or may be maintained in an episomal state, e.g., carried on a plasmid.
Adjuvants may also be added to compositions containing bacterial vector vaccines. A variety of adjuvants are known to those skilled in the art. For example, preferred adjuvants may be selected from the list provided below.
According to a fourth aspect of the invention, there is also provided (i) a composition comprising a polynucleotide of the invention and a diluent or carrier; (ii) a pharmaceutical composition comprising a therapeutically or prophylactically effective amount of a polynucleotide of the present invention; (iii) a method of inducing an immune response to helicobacter in a mammal, such as, for example, a protective immune response to helicobacter, by administering to the mammal an immunologically effective amount of a polynucleotide of the invention; (iv) a method of preventing and/or treating helicobacter (e.g., helicobacter pylori, helicobacter feline, helicobacter ferret, or Helminthobacter) infection by administering to a subject in need of such treatment a prophylactic or therapeutic amount of a polynucleotide of the present invention. In addition, the fourth aspect of the present invention includes the use of a polynucleotide of the present invention for the preparation of a medicament for the prevention and/or treatment of helicobacter infection. The fourth aspect of the invention preferably comprises the use of the polynucleotide molecule under conditions for expression in mammalian cells, for example, in a plasmid which is incapable of replication in mammalian cells and, furthermore, of substantial integration into the mammalian genome.
The polynucleotides of the invention (e.g., DNA or RNA molecules) can also be administered to a mammal as a vaccine. In using the DNA molecules of the invention, the molecules may be in the form of plasmids which are incapable of replication in mammalian cells and, furthermore, of integration into the mammalian genome. Typically, the DNA molecule is placed under the control of a promoter suitable for expression in mammalian cells. The promoter may function generally or in a tissue-specific manner. Examples of non-tissue specific promoters include the early Cytomegalovirus (CMV) promoter (US4,168,062) and the rous sarcoma virus promoter (Norton et al, molecular cell biology 5: 281, 1985). The desmin promoter (Li et al, Gene 78: 243, 1989; Li et al, J. biol. 266: 6562, 1991; Li et al, J. biol. 268: 10403, 1993) is tissue specific and can initiate expression in muscle cells. More generally, useful promoters and vectors are disclosed in, for example, WO94/21797 and Hartikka et al (human gene therapy 7: 1205, 1996).
For DNA/RNA immunization, a polynucleotide of the invention may encode a precursor or mature form of a polypeptide of the invention. When it encodes a precursor form, the precursor sequence may be homologous or heterologous. In the latter case, a eukaryotic leader sequence, such as that of tissue-type plasminogen factor (tPA), may be used.
The compositions of the invention may contain one or more polynucleotides of the invention. It may also contain at least one other polynucleotide encoding another helicobacter antigen such as the urease a subunit, B subunit, or both subunits, or a fragment, derivative, mutant, or analog thereof. Polynucleotides encoding cytokines such as interleukin-2 (IL-2) or interleukin-12 (IL-12) may also be added to the composition in order to enhance the immune response. The other polynucleotides are subject to appropriate expression control. Preferably, the DNA molecule of the invention and/or the further DNA molecule may be contained in the same composition and carried on the same plasmid.
Therapeutic polynucleotides of the invention can be prepared by standard methods. For example, the polynucleotide may be used in naked form, without any delivery vehicle, such as anionic liposomes, cationic lipids, microparticles, e.g., gold microparticles, a precipitating agent such as calcium phosphate, or any other transfection-facilitating agent. In this case, the polynucleotide may simply be diluted in a physiologically acceptable solution, such as sterile saline or sterile buffered saline with or without a carrier. When present, the carrier is preferably of the isotonic, hypotonic, or weakly hypertonic type and has a lower ionic strength, as provided by a sucrose solution, such as a 20% sucrose solution.
In addition, the polynucleotide may be conjugated to an agent that facilitates cellular uptake. For example, it may be (i) complementary to a chemical agent that alters cell permeability such as bupivacaine (see, e.g., WO94/16737), (ii) encapsulated in liposomes, or (iiii) bound to cationic lipids or silicon, gold, or tungsten microparticles.
Anionic and neutral liposomes are well known in the art (e.g., see: liposomes: methods of practice, new RPC edition, IRL Press, 1990 for a detailed description of methods for making liposomes) and can be used to deliver a variety of preparations including polynucleotides.
Cationic lipids can also be used for gene delivery. For example, such lipids include LipofectinTMIt is also known as DOTMA (N- [1- (2, 3-dioleoyloxy) propyl)]-N, N-trimethylammonium chloride), DOTAP (1, 2-bis (oleoyloxy) -3- (trimethylammonium) propane), DDAB (dioctadecylammonium bromide), DOGS (octadecylaminogenin amine), and cholesterol derivatives. In connection with these cationic typesDescription of lipids can be found in EP187, 702, WO90/11092, US5,283,185, WO91/15501, WO95/26356, and US5,527,928. Cationic lipids for gene delivery are preferably used in combination with neutral liposomes such as DOPE (dioleoylphosphatidylethanolamine; WO 93/11092). Other transfection-facilitating compounds may be added to the cationic liposome-containing formulation. A variety of such compounds are disclosed in documents such as WO93/18759, WO93/19768, WO94/25608 and WO 95/2397. For example, spermine derivatives useful for promoting transport of DNA through the nuclear membrane (see, e.g., WO93/18759) and membrane permeable compounds such as GALA, gramicidin S, and cationic bile salts (see, e.g., WO93/19768) are included.
Gold or tungsten microparticles may also be used for gene delivery as disclosed in WO91/359, WO93/17706 and Tang et al (Nature 356: 152, 1992). In this case, the microparticle-coated polynucleotide may be injected by an intradermal or intraepidermal route using a needle-less injection device ("gene gun"), as disclosed in the following patent documents: U.S. Pat. No. 4,945,050, U.S. Pat. No. 5,015,580, and WO 94/24263.
For example, the amount of DNA used in a vaccine recipient depends on the strength of the promoter used on the DNA construct, the immunogenicity of the expressed gene product, the condition of administration to the mammal (e.g., the weight, age, and general health of the mammal), the mode of administration, and the type of formulation. Generally, a therapeutically or prophylactically effective dose for administration to an adult human is from about 1 μ g to about 1mg, preferably from about 10 μ g to about 800 μ g, more preferably from about 25 μ g to about 250 μ g. The administration can be done repeatedly with 1 dose or at intervals.
The route of administration may be any conventional route used in the vaccine art. As a general guideline, the polynucleotides of the invention may be administered by mucosal surfaces, e.g., by ocular, nasal, pulmonary, oral, intestinal, rectal, vaginal, or urethral surfaces, or by parenteral routes, e.g., by intravenous, subcutaneous, intraperitoneal, intradermal, intraepidermal, or intramuscular routes. For example, the choice of route of administration depends on the formulation chosen. Polynucleotides prepared in conjunction with bupivacaine are preferably used in the intramuscular route. When neutral or anionic or cationic liposomes such as DOTMA are used, the formulation is preferably injected by intravenous, nasal (e.g., by aerosolization), intramuscular, intradermal, and subcutaneous routes. The naked form of the polynucleotide is preferably administered by intramuscular, intradermal or subcutaneous routes. Although not absolutely necessary, the composition may also contain an adjuvant. Systemic adjuvants that produce an adjuvant effect without the need for simultaneous administration are preferred.
The sequence data provided in this application enables the design of specific nucleotide probes and primers that can be used in diagnostic methods. Thus, in a fifth aspect of the invention, there is provided a nucleotide probe or primer whose sequence is present in or is generated from the sequence shown in the sequence listing (odd numbers, up to sequence 1363) by the degeneracy of the genetic code.
As used herein, "probe" refers to a DNA (preferably single-stranded), preferably RNA molecule (or a modification or combination thereof) that hybridizes under the stringent conditions described above to a polynucleotide molecule whose sequence is homologous to any one of the sequences in the sequence Listing (odd-numbered, up to sequence 1363) or complementary to an antisense sequence of any one of the sequences in the sequence Listing (odd-numbered, up to sequence 1363). In general, the probes are significantly shorter than the full length sequences shown in the sequence listing. For example, it may contain from about 5 to about 100, preferably fromabout 10 to about 80 nucleotides. In particular, the sequence of the probe has at least 75%, preferably at least 85%, more preferably 95% homology to a portion of the sequence shown in the sequence listing (odd numbers, up to sequence 1363) or a sequence complementary to any of said sequences.
The probe may contain a modified base such as inosine, methyl-5-deoxycytidine, deoxyuridine, dimethylamino-5-deoxyuridine, or diamino-2, 6-purine. Sugar or phosphate residues may also be modified or substituted. For example, the deoxyribose residue can be substituted with a polyamide (Nielsen et al, science 254: 1497, 1991), while the phosphate residue can be substituted with ester groups such as diphosphates, alkyl, aryl phosphates, and thiophosphates. In addition, the 2' -hydroxyl group on the ribonucleotide may be modified by adding a group such as an alkyl group.
The probes of the invention may be used in diagnostic assays, or as capture or detection probes. The capture probe may be immobilized directly or indirectly on the solid support by covalent means or by passive adsorption. The detection probe may also be labeled with a detectable label, for example, the label may be selected from a radioisotope; enzymes such as peroxidase and alkaline phosphatase; an enzyme capable of hydrolyzing a chromogenic, fluorogenic, or luminescent substrate; chromogenic, fluorogenic, or luminescent compounds; a nucleotide base analog; and biotin.
The probes of the invention can be used in all conventional hybridization methods, such as the dot blot method (Maniatis et al, molecular cloning: A laboratory Manual, Cold spring harbor laboratory Press, Cold spring harbor, N.Y., 1982), the Southern blot method (Southern, J. mol. biol. 98: 503, 1975), the Northern blot method (the same as the Southern blot method except that RNA is used as the target molecule), or the sandwich method (Dunn et al, cells 12: 23,1977). The latter technique involves the use of specific capture probes and specific detection probes, the nucleotide sequences of which differ at least in part from each other, as is well known in the art.
Primers used in the present invention typically contain about 10-40 nucleotides and are used to initiate enzymatic polymerization of DNA during an amplification process (e.g., PCR), an extension process, or a reverse transcription process. In diagnostic methods involving PCR, the primers may be labeled.
Accordingly, the invention also includes (i) a formulation comprising a probe of the invention for detecting and/or identifying the presence of helicobacter in a biological material; (ii) a method for detecting and/or identifying the presence of helicobacter in a biological material, wherein (a) a sample recovered from or derived from said biological material, (b) DNA or RNA isolated and denatured from said material, and (c) said sample is contacted with a probe of the invention, e.g., a capture probe, a detection probe, or both, under stringent hybridization conditions, to detect hybridization; and (iii) a method for detecting and/or identifying the presence of helicobacter in a biological material, wherein (a) a sample is recovered from or derived from said biological material, (b) DNA is isolated therefrom, and (c) the isolated DNA is contacted with at least one, or preferably two, primers of the invention and amplified by polymerase chain reaction, and (d) amplified DNA molecules are produced.
As described above, polypeptides that can be produced by expression of the polynucleotides of the present invention can be used as vaccine antigens. Accordingly, a sixth aspect of the invention features a substantially pure polypeptide or polypeptide derivative having an amino acid sequence encoded by a polynucleotide of the invention.
A "substantially pure polypeptide" is defined as a polypeptide that is isolated from its naturally occurring environment and/or a polypeptide that is free of most other polypeptides that are present in its synthetic environment. The polypeptides of the invention may be purified from natural sources, such as helicobacter strains, or produced by recombinant methods.
Homologous polypeptides or polypeptide derivatives encoded by polynucleotides of the invention can be screened for their specific antigenicity by detecting cross-reactivity with antisera raised against polypeptides having the amino acid sequences shown in the sequence listing (even numbered up to sequence 1364). Briefly, a monospecific hyperimmune antiserum against a purified reference polypeptide, such as an expression product of a polypeptide or fusion polypeptide, e.g., MBP, GST, or His-tag system, or a synthetic peptide predicted to be an antigen, can be prepared. Homologous polypeptides or derivatives for screening for specific antigenicity can be produced as polypeptides or as fusion polypeptides. In the latter case, two different fusion systems are used if the antiserum is directed against one fusion polypeptide. Specific antigenicity can be determined by a variety of methods, including Western blotting (Towbin et al, Proc. Natl. Acad. Sci. USA 76: 4350, 1979), dot blotting, and ELISA methods, as described below.
The products to be screened in the Western blot analysis were preparations purified by SDS-PAGE isolation or total E.coli extracts as described by Laemmli (Nature 227: 680, 1970). After transfer to a filter such as a nitrocellulose membrane, the material is incubated with the monospecific hyperimmune antiserum, which is diluted in a ratio of about 1: 50 to 1: 5000, preferably about 1: 100 to about 1: 500. Specific antigenicity was confirmed as soon as a band reactivity equivalent to the product appeared in any dilution within the range.
In an ELISA assay, the product to be screened can be used as a coating antigen. Purified preparations are preferred, however, whole cell extracts may also be used. Briefly, approximately 100. mu.l of a formulation having a concentration of approximately 10. mu.g protein/ml was dispensed into wells of a 96-well ELISA plate. The plates were incubated at 37 ℃ for approximately 2 hours, then at 4 ℃ overnight. The plates were washed with Phosphate Buffered Saline (PBS) containing 0.05% Tween 20 (PBS/Tween buffer) and the wells were saturated with 250 μ l PBS containing 1% Bovine Serum Albumin (BSA) to prevent non-specific antibody binding. Incubate at 37 ℃ for 1 hour, then wash the plate with PBS/Tween buffer. The antisera were serially diluted in PBS/Tween buffer containing 0.5% BSA and 100. mu.l of the dilution was added to each well. The plates were incubated for 90 minutes at 37 ℃, washed and then evaluated using standard methods. For example, when the specific antibody used is produced in rabbits, a goat anti-rabbit peroxidase conjugate may be added to the wells. Incubate at 37 ℃ for approximately 90 minutes, then wash the plate. The reaction is carried out with a suitable substrate and the reaction is determined colorimetrically (absorption by spectrophotometry). Under the above experimental conditions, a positive reaction is confirmed once an O.D. value of 1.0 is detected with a dilution of at least about 1: 50, preferably at least about 1: 500.
In dot blot assays, purified products are preferred, however, whole cell extracts may also be used. Briefly, 50mM is used (pH7.5) A solution of the product at a concentration of about 100. mu.g/ml was serially diluted 2-fold. 100 μ l of each dilution is applied to a filter, such as a 0.45 μm nitrocellulose membrane, and placed in a 96-well dot blot apparatus (Biorad). The buffer was removed by applying a vacuum to the system. By adding 50mM (pH7.5) the wells were washed and the membranes were air dried. In blocking buffer (50 mM) (pH7.5)，0.15M 10g/L skim milk) and incubated with antiserum diluted about 1: 50 to about 1: 5000, preferably about 1: 500. The reaction was checked by standard methods. For example, when rabbit antibodies are used, goat anti-rabbit peroxidase conjugate can be added to the wells. The blot was washed by incubation at 37 ℃ for approximately 90 minutes. Reacting with a suitable substrate and terminating the reaction. The reaction is determined by observation based on the presence of colored spots, for example, by colorimetry. Under the above experimental conditions, a positive reaction is associated with a colored spot detected in a reaction with a dilution of at least about 1: 50, preferably at least 1: 500. The therapeutic or prophylactic efficacy of the polypeptide or polypeptide derivative of the present invention can be evaluated as described below.
According to a seventh aspect of the invention, there is provided (i) a composition comprising a polypeptide of the invention and a diluent or carrier; (ii) a pharmaceutical composition comprising a therapeutically or prophylactically effective amount of a polypeptide of the invention; (iii) a method of inducing an anti-helicobacter immune response in a mammal by administering to the mammal an immunologically effective amount of a polypeptide of the invention to induce an immune response, e.g., a protective immune response against helicobacter; and (iv) a method for preventing and/or treating helicobacter (e.g., helicobacter pylori, helicobacter feline, helicobacter ferret, or helicobacter marini) infection by administering to a subject in need of such treatment a prophylactically or therapeutically effective amount of a polypeptide of the invention. In addition,this aspect of the invention includes the use of a polypeptide of the invention for the preparation of a medicament for the prevention and/or treatment of helicobacter infection.
The immunological composition of the invention may be administered by any conventional route used in the field of immunization, for example, for mucosal (ocular, nasal, pulmonary, oral, gastric, intestinal, rectal, vaginal, or urethral) surfaces or by parenteral (e.g., subcutaneous, intradermal, intramuscular, intravenous, or intraperitoneal) routes. The choice of route of administration depends on various parameters, such as the adjuvant used. For example, if a mucosal adjuvant is used, the nasal or oral route is preferred, and if a lipid preparation or an aluminum compound is used, the parenteral route is preferred. In the latter case, the subcutaneous or intramuscular route is preferred. The choice of route of administration may also depend on the nature of the vaccine formulation. For example, polypeptides of the invention fused to CTB or LTB are preferably applied to mucosal surfaces.
The composition of the invention may contain one or more polypeptides or derivatives of the invention, and it may also contain at least one other helicobacter antigen, such as urease dehyrocoenzyme, or a methyl, fragment, homologue, mutant, or derivative thereof.
For use in the compositions of the invention, the polypeptide or polypeptide derivative may be formulated into or prepared with liposomes, such as neutral or anionic liposomes, microspheres, ISCOMS, or virus-like particles (VLPs), in order to facilitate and/or enhance the immune response. These compounds are readily available to those skilled in the art; see, for example: liposome: the method was practiced (supra). Adjuvants other than liposomes can also be used in the present invention, and are well known in the art (see, e.g., adjuvants listed below).
Administration may be repeated in a single dose or at intervals as desired, as may be determined by one skilled in the art. For example, three booster doses may follow immediately after a priming dose, at weekly or monthly intervals. The appropriate dosage will depend upon a variety of parameters, including the nature of the recipient (e.g., whether the recipient is an adult or an infant), the particular vaccine antigen, the route and number of administrations, the presence/absence or type of adjuvant, and the desired effect (e.g., prevention and/or treatment), and can be readily determined by one skilled in the art. In general, the vaccine antigens of the present invention may be administered mucosally in an amount of from about 10. mu.g to about 500mg, preferably from about 1. mu.g to about 200 mg. For parenteral routes of administration, the dose should generally not exceed about 1mg, preferably about 100 μ g.
When the polynucleotides and polypeptides of the invention are used as vaccine components, the sequence may be used as part of a multi-step immunization process. For example, a mammal may be first primed parenterally with a vaccine vector of the invention, such as a poxvirus, and then boosted twice, such as mucosally, with a polypeptide encoded by the vaccine vector. In another example, a polypeptide or polypeptide derivative of the invention conjugated to a liposome may be used for priming, enhanced by a mucosal route using a soluble polypeptide or polypeptide derivative of the invention in combination with a mucosal adjuvant (e.g., LT).
The polypeptides and polypeptide derivatives of the invention may also be used as diagnostic agents for detecting the presence of anti-helicobacter antibodies in, for example, a blood sample. The polypeptides may be about 5 to about 80 amino acids in length, preferably about 10 to about 50 amino acids in length, and may be labeled or unlabeled depending on the diagnostic method involved. Diagnostic methods involving the formulations are disclosed below.
Upon expression of the polynucleotide molecule of the invention, a polypeptide or polypeptide derivative is produced and can be purified by known methods. For example, the polypeptide or polypeptide derivative may be produced as a fusion protein containing a fusion tail that facilitates purification. Small mammals such as mice or rabbits may be immunized with the fusion product in order to generate monospecific antibodies against the polypeptide or polypeptide derivative. Accordingly, in an eighth aspect the invention provides a monospecific antibody which binds to a polypeptide or polypeptide derivative of the invention.
By "monospecific antibody" is meant an antibody that is reactive with a single, naturally occurring helicobacter polypeptide. The antibody of the present invention may be a polyclonal antibody or a monoclonal antibody. Monospecific antibodies can be recombinant, e.g., chimeric (e.g., including a murine-derived variable region and a human constant region), humanized (e.g., a human immunoglobulin constant region and an animal-derived variable region such as murine), and/or single-chain. Monoclonal and monospecific antibodies may also be in the form of immunoglobulin fragments, for example, f (ab)' 2 or fab fragments. The antibodies of the invention may be of any isotype, for example, IgG or IgA, while polyclonal antibodies may be of a single isotype or may comprise a mixture of several isotypes.
Antibodies of the invention can be raised against a polypeptide or polypeptide derivative of the invention and can be produced and characterized by standard immunological analytical methods, such as Western blot analysis, dot blot analysis, or ELISA (see, e.g., Coligan et al, Current immunology methods, John Wiley&Sons, N.Y., 1994). The antibodies can be used in methods for detecting the presence of helicobacter antigens in a sample, such as a biological sample. The antibodies may also be used in affinity chromatography methods for purifying the polypeptides or polypeptide derivatives of the invention. As will be discussed further below, the antibodies may also be used in prophylactic and therapeutic passive immunization methods.
Accordingly, a ninth aspect of the invention provides (i) a preparation for detecting the presence of helicobacter in a biological sample, the preparation comprising an antibody, polypeptide, or polypeptide derivative of the invention; and (ii) a diagnostic method for detecting the presence of helicobacter in a biological sample, which method comprises contacting said biological sample with an antibody, polypeptide, or polypeptide derivative of the invention, so as to form an immune complex, and detecting the complex as an indication of the presence of helicobacter in said sample or in the organism from which the sample was obtained. The immune complex is formed by a component of the sample and the antibody, polypeptide, or polypeptide derivative, and any unbound material may be removed prior to detection of the complex. The polypeptide preparation can be used to detect the presence of anti-helicobacter antibodies in a sample, such as a blood sample, while the antibodies of the invention can be used to screen samples, such as a gastric extract or biopsy sample, for the presence of helicobacter polypeptide.
For use in diagnostic methods, the agent (e.g., an antibody, polypeptide, or polypeptide derivative of the invention) can be in a free state or immobilized on a solid support, such as on the interior surface of a test tube or on the surface of a bead or well. Immobilization may be performed by direct or indirect methods. Direct methods include passive adsorption (e.g., non-covalent binding) or covalent binding between the support and the reagent. By "indirect method" is meant that theanti-reagent compound that interacts with the reagent is first attached to the solid support. For example, if a polypeptide agent is used, an antibody that binds thereto can be used as an anti-agent, provided that it binds to an epitope that is not involved in recognition of the antibody in the biological sample. Indirect methods can also employ a ligand-receptor system, e.g., a molecule such as a vitamin can be grafted onto the polypeptide preparation and the corresponding receptor immobilized on the stationary phase. This concept can be illustrated by the well-known biotin-streptavidin system. In addition, the indirect method can also be used as follows: for example, a peptide tail is added to the agent by chemical or genetic engineering methods and the grafted or fused product is immobilized by passive adsorption or covalent attachment of the peptide tail.
According to a tenth aspect of the present invention there is provided a method for purifying a polypeptide or polypeptide derivative of the present invention from a biological sample, the method comprising performing antibody-based affinity chromatography with the biological sample, wherein the antibody is a monospecific antibody of the invention.
For use in the present invention, the antibody may be a polyclonal or monoclonal antibody, and is preferably of the IgG type. Purified IgGs can be prepared from antisera using standard methods (see, e.g., Coligan et al, supra). For example, conventional chromatographic supports and standard methods for grafting antibodies are disclosed in Harlow et al (antibodies: A laboratory Manual, Cold spring harbor laboratory Press, Cold spring harbor, N.Y., 1988).
Briefly, a biological sample, such as an extract of helicobacter pylori, preferably contained in a buffer solution, is applied to a chromatographic material, which is preferably equilibrated with the buffer used to dilute the biological sample, so as to adsorb the polypeptide or polypeptide derivative (i.e., antigen) of the present invention to the material. The chromatographic material such as a gel or resin to which the antibody of the present invention is bound may be in a batch form or a column form. Unbound components are washed away and the antigen is eluted with a suitable elution buffer, such as a glycine buffer, containing a chaotropic agent, such as guanidine hydrochloride, or a buffer with a high salt concentration (e.g., 3M magnesium chloride). The eluted fractions are recovered and the presence of the antigen is detected, for example, by measuring the light absorption at a wavelength of 280 nm.
Antibodies of the invention can be screened for therapeutic efficacy as described below. According to an eleventh aspect of the invention, there is provided (i) a composition comprising a monospecific antibody of the invention and a diluent or carrier; (ii) (ii) a pharmaceutical composition comprising a therapeutically or prophylactically effective amount of a monospecific antibody of the invention, and (iii) a method of treating or preventing helicobacter (e.g. helicobacter pylori, helicobacter felis, helicobacter ferret or helicobacter marini) infection by administering to a subject in need of such treatment a therapeutically or prophylactically effective amount of a monospecific antibody of the invention. In addition, an eleventh aspect of the invention includes the use of a monospecific antibody of the invention for the manufacture of a medicament for the treatment or prevention of helicobacter infection.
The monospecific antibody may be a polyclonal or monoclonal antibody and, preferably, is predominantly of the IgA isotype. In passive immunization methods, the antibody is administered to a mucosal surface of a mammal, such as the gastric mucosa, by, for example, the oral or intragastric route, optionally in the presence of a bicarbonate buffer. In addition, systemic administration without bicarbonate buffer may also be performed. The monospecific antibody of the invention may be administered as a single active agent or as a mixture with at least one other monospecific antibody specific for a different helicobacter polypeptide. The amount of antibody used and the particular protocol used can be readily determined by one skilled in the art. For example, administration of about 100-1000mg of antibody per day, over a period of one week, or three doses of about 100-1000mg of antibody per day, for 2 or 3 days, may be effective as a regimen for most uses.
Therapeutic or prophylactic efficacy can be assessed by standard methods in the art. For example, evaluation is carried out by determining the induction of a mucosal immune response or the induction of protective and/or therapeutic immunity using mouse models such as H.felis and the methods disclosed by Lee et al (J.European gastroenteropathy and liver disease 7: 303, 1995) or Lee et al (J.infectious disease 172: 161, 1995). It will be appreciated by those skilled in the art that the model helicobacter felis strain may be replaced by another helicobacter strain. For example, the efficacy of polynucleotide molecules and polypeptides derived from helicobacter pylori is preferably evaluated in mouse models using strains of helicobacter pylori. The protective effect of helicobacter infection in stomach tissue can be determined by comparison with a control group, for example, by comparing urease activity, bacterial count, or gastritis. Protection was demonstrated when infection was reduced compared to the control group. Such evaluations can be carried out with polynucleotides, vaccine vectors, polypeptides, and polypeptide derivatives, as well as the antibodies of the present invention.
For example, various doses of the antibodies of the invention can be applied to the mouse gastric mucosa prior to challenge with a strain of helicobacter pylori, as described by Lee et al (supra). Then, after an appropriate time has elapsed, the bacterial load of the mucosa is estimated by measuring urease activity and comparing it with a control. The reduced urease activity indicates that the antibody is therapeutically effective.
Adjuvants useful in any of the above vaccine compositions are disclosed below. For example, adjuvants for parenteral administration include aluminum compounds such as aluminum hydroxide, aluminum phosphate, and aluminum hydroxyphosphate. The antigen can be precipitated with the aluminum compound or adsorbed onto the aluminum compound using standard methods. Other adjuvants such as RIBI (immunological Chem, Hamilton, MT) may also be used for parenteral administration.
For example, adjuvants that may be used for mucosal administration include bacterial toxins, such as Cholera Toxin (CT), escherichia coli heat Labile Toxin (LT), clostridium difficile (clostridium difficile) toxin a, Pertussis Toxin (PT), and combinations, subunits, toxoids, or mutants thereof. For example, purified preparations of the B subunit of native Cholera Toxin (CTB) can be used. Fragments, homologs, derivatives, and fusions of the above toxins may also be used, so long as they retain adjuvant activity. Preferably, mutants with reduced toxicity are used. For example, suitable mutants are disclosed in WO95/17211(Arg-7-Lys CT mutant), WO96/6627(Arg-192-Gly LT mutant), and WO95/34323(Arg-9-Lys and Glu-129-Gly PT mutant). For example, other LT mutants that may be used in the methods and compositions of the invention include Ser-63-Lys, Ala-69-Gly, Glu-110-Asp, and Glu-112-Asp mutants. Bacterial monophosphoryl lipid a (MPLA), such as MPLA from escherichia coli, salmonella minnesota, salmonella typhimurium, or shigella flexneri; saponins, and other adjuvants for polylactide glycolide (PLGA) microspheres for mucosal administration. Adjuvants for mucosal and parenteral administration such as polyphosphazene (WO95/2415) may also be used.
All pharmaceutical compositions of the invention containing a polynucleotide, polypeptide derivative, or antibody of the invention can be prepared by standard methods. The composition may be formulated with a pharmaceutically acceptable diluent or carrier, for example, water or a saline solution, such as a phosphate buffered saline solution, optionally containing a bicarbonate salt such as sodium bicarbonate, for example, 0.1-10.5M. Preferably, the bicarbonate is added to a composition for oral or intragastric administration. In general, the diluent or carrier will be selected with regard to the mode and route of administration, and standard pharmacological practice. Suitable pharmaceutical carriers and diluents, and pharmacology for their use in pharmaceutical formulations, are disclosed in the Remington's Pharmacology book, which is a standard reference in the art and is disclosed in USP/NF.
The invention also includes methods of conjugating helicobacter polypeptides of the invention to mucosal adjuvants by oral administrationExamples of such compounds that may be administered with the vaccine antigens and adjuvants are antibiotics, including, for example, macrolides, tetracyclines, β -lactams, aminoglycosides, quinolones, penicillins, and derivatives thereof (e.g., specific examples of antibiotics useful in the present invention include amoxicillin, clarithromycin, tetracycline, metronidazole, erythromycin, cefuroxime, and erythromycin), antisecretory agents, including, for example, H, and combinations thereof2Receptor antagonists (e.g. cimetidine, ranitidine, famotidine)Butadine, nizatidine, and roxatidine), proton pump inhibitors (e.g., misoprostil and enprostil), and anticholinergics (e.g., pirenzepine, telenzepine, carbenoxolone, and proglumide); and bismuth salts, including colloidal bismuth subcitrate, tripotassium bismuthate, bismuth subsalicylate, bicitratide and pepto-bismol (see, e.g., Goodwin et al, helicobacter pylori, biological and clinical practice, CRC Press, Boca Raton, FL, pp366-395, 1993; physicians' own reference, 49 th edition, medical economic data production, Montvale, New Jersey, 1995). In addition, compounds containing more than one of the above components linked together, for example, ranitidine linked to bismuth subcitrate, may be used. The invention also includes compositions for carrying out the above methods, i.e., comprising one helicobacter antigen (or antigens) of the present invention, an adjuvant, and more than one of the above compounds in a pharmaceutically acceptable carrier or diluent.
The amount of the above-described compounds used in the methods and compositions of the present invention can be readily determined by one skilled in the art. The skilled person can easily design a treatment/immunization protocol. For example, the non-vaccine component may be administered on days 1-14, while the vaccine antigen + adjuvant is administered on days 7, 14, 21, and 28.
The methods and pharmaceutical compositions of the invention are useful for treating or preventing helicobacter infection, and accordingly for treating or preventing gastroduodenal diseases associated with such infection, including acute, chronic, and atrophic gastritis, as well as peptic ulcer diseases such as gastric and duodenal ulcers.
The invention will be further illustrated by the following examples. Example 1 discloses the identification of genes, such as the gene encoding a polypeptide of the invention, in the helicobacter genome, as well as the identification of signal sequences, and primer designs for amplifying genes lacking signal sequences. Example 2 discloses the cloning of a DNA molecule encoding a polypeptide of the invention into a vector having a histidine tag, and the production and purification of the resulting histidine-tagged fusion protein. Example 3 discloses a method for cloning a DNA encoding a polypeptide of the present invention so that the resulting polypeptide is free of a histidine tag, while example 4 discloses a method for the purification of a recombinantly produced polypeptide of the present invention.
Example 1: identification of genes in the H.pylori genome, identification of signal sequences, and primer design for amplification of genes lacking signal sequences
Preparation of helicobacter pylori genomic database
The H.pylori genome is provided in the form of a text file containing a single continuous nucleotide string, the length of which is determined to be 1.76 megabases. The program SPLIT (creative in action) was used to divide the entire genome into 17 independent files, resulting in 16 contigs (contigs), each containing 100,000 nucleotides, while the 17 th contig contained the remaining 76,000 nucleotides. Add a cap to each of the 17 files using the following scheme: tpgo (for contig 1),. hpg1.txt (for contig 2), etc. The 17 files obtained were named hpg0 to hpg16 and then copied together to form one file representing the addition chain of the entire H.pylori genome. The constructed database is named "H". A negative strand database of the helicobacter pylori genome was constructed in a similar way, first, the reverse complement of the positive strand was prepared with the program SeqPup (d.g. gilbert, indiana university biotine), and then the same procedure was performed as for the positive strand. This database is named "N".
The fragments of the entire H.pylori genome which are predicted to code for Open Reading Frames (ORFs) were determined by the program GENEMARKTM (Borodovsky et al, Comp. chem.17: 123, 1993). A database was created with a text file containing all ORFs expected to be encoded by the positive and negative strands of the H.pylori genomein annotated form and named "O". Each ORF is given a number indicating its position in the genome and its position relative to other genes, and no manipulation of the text file is required.
B. search of H.pylori database
The database constructed as described above was searched using the program FASTA (Pearson et al, Proc. Natl. Acad. Sci. USA: 2444-. The DNA sequences of the gene databases ("H" and/or "N") or the peptide sequences of the ORF libraries ("O") were searched using FASTA. TFASTX was used to search for peptide sequences in all possible reading frames of DNA databases ("H" and/or "N" libraries). Potential frameshifts were also analyzed, using FASTX to screen for translational reading frames of DNA sequences in DNA databases, or peptide sequences in protein databases.
C. extraction of DNA sequences from the genome of helicobacter pylori
FASTA searches of the constructed DNA databases identified the exact nucleotides that matched one or several of the isolated contigs and thus identified the location of the target DNA. Once the exact location of the target sequence is known, the contigs identified as carrying the gene can be imported into the software package mapdata (DNAStar, inc.) and the gene isolated. The gene sequence with flanking DNA was then excised and copied to the editseq.
Identification of Signal sequences
The putative protein encoded by the target gene sequence was analyzed using the Protean software package (DNASAR, Inc.). This analysis predicts hydrophobic sites in the protein by the Kyte-Doolittle algorithm and identifies all potential polar residues preceding the hydrophobic core region, which are common in many signal sequences. For confirmation, the target protein was subsequently retrieved in the PROSITE database (DNAStar corporation) comprising motifs and markers. In general, many signal sequences and hydrophobic regions are characterized by the ability to identify putative prokaryotic lipid binding sites. Once the presence at the N-terminus of any protein is confirmed by both approaches, the putative cleavage site is found. Specifically, the presence of an alanine (A), serine (S), or glycine (G) residue immediately following the hydrophobic region is included. For lipoproteins, after cleavage, the cysteine (C) residue will be identified as the +1 residue.
Rational design of PCR primers based on the identification of Signal sequences
In order to clone gene sequences such as N-terminal translational fusions in order to prepare recombinant proteins having an N-terminal histidine tag, the gene sequences determining the signal sequence are omitted. The 5' -end of the gene specific part of the N-terminal primer is designed to start with the first codon outside the cleavage site. For lipoproteins, the 5' -end of the N-terminal primer begins at a second codon immediately following the residue that is modifiable after cleavage at position +1. In such recombinants, the omission of the signal sequence allows one-step purification and avoids potential problems associated with insertion of the signal sequence into the cell membrane of the host strain carrying the hybrid structure.
Example 2: preparation of an isolated DNA encoding a polypeptide of the invention and production of said polypeptide in the form of a histidine-tagged fusion protein
Preparation of genomic DNA from helicobacter pylori
Under microaerophilic conditions (8-10% ，5-7％O2，85-87％ ) Helicobacter pylori strain ORV2001, stored at-70 ℃ in LB medium containing 50% glycerol, was grown on Colombia agar containing 7% sheep blood for 40 hours. The cells were harvested, washed with Phosphate Buffered Saline (PBS) (pH7.2), and then DNA was extracted using a Rapid preparation genomic DNA extraction kit (Pharmacia Biotech).
B.PCR amplification
The DNA molecule encoding the polypeptide of the present invention is amplified from genomic DNA by Polymerase Chain Reaction (PCR) using primers that can be conveniently designed by one skilled in the art, as described above. Specific examples of primers that can be used in the present invention are shown in table 1. As specific examples of amplifying genes encoding GHPO147, GHPO615, GHPO961, GHPO1282, GHPO296, and GHPO840, the following primers can be used:
CHPO 147: 5'-CTGAATTCGAATGAAAAGAATTTTAGTCTCT-3' (SEQ ID NO: 1365), and
5'-CCGCTCGAGTTAAAACTCATAATTCAAAT-3' (SEQ ID NO: 1366).
CHPO 615: 5'-CGCGGATCCGAAGACATGTGCAACCGATG-3' (SEQ ID NO: 1367), and
5'-CCGCTCGAGCTAAAAGTTTTGCAAAATCAC-3' (SEQ ID NO: 1368).
CHPO 961: 5'-CGCGGATCCGATTTTACTTGAAAAATTTAAAC-3' (SEQ ID NO: 1369), and
5'-CCGCTCGAGTTAGAAAGTGTAGTTCAAATAC-3' (sequence 1370).
CHPO 1282: 5'-GCGGATCCTTTTCTTCAATGTTTG-3' (SEQ ID NO: 1371), and
5'-CCGCTCGAGTCAAAGTTTTAAACAAATTC-3' (SEQ ID NO: 1372).
CHPO 296: 5'-CCGAATTCGGTTATAAAGCCCCT-3' (SEQ ID NO: 1373), and
5'-CCGCTCGAGTTAAGGCTGATTTAA-3' (SEQ ID NO: 1374).
CHPO 840: 5'-CGCGGATCCGAGGAAATAGCATGTTAATAACC-3' (sequence 1375), and
5'-CCGCTCGAGTCACTGCTTGCATGACTTATTCCA-3' (SEQ ID NO: 1376).
The N-terminal and C-terminal primers used for each clone may each include a 5' hairpin structure and a restriction enzyme recognition sequence (e.g., BamHI (GGATCC) and XhoI (CTCGAG) recognition sequences) for cloning purposes.
Gene-specific DNA was amplified using either VentDNA polymerase (New England Biolabs) or Taq DNA polymerase (Appligene) according to the manufacturer's instructions. The final volume of the reaction mixture, which had the following composition, was adjusted to 100. mu.l with distilled water:
dNTPs mixture 200. mu.M
10 μ l of 10 × ThermoPol buffer
Primers were 300nM each
50ng of DNA template
Thermostable DNA polymerase 2 units
Suitable amplification reaction conditions can be readily determined by one skilled in the art. For example, DNA encoding GHPO615 can be amplified using the primers listed above using the following conditions: denaturation was started at 94 ℃ for 5 min, 25 rounds of denaturation at 97 ℃ for 30 sec, hybridization at 55 ℃ for 1 min, and extension with VentDNA polymerase at 72 ℃ for 2 min. In amplifying DNA encoding GHPO1282 using the above primers, the following conditions may be used: denaturation was started at 94 ℃ for 5 min, 25 rounds at 94 ℃ for 30 sec, hybridization at 45 ℃ for 30 sec, and extension at 72 ℃ for 30 sec, followed by final extension at 72 ℃ for 7 min with VentDNA polymerase. DNA encoding GHPO840 can be amplified using the primers described above using the following conditions: 25 rounds of denaturation were performed at 97 ℃ for 30 seconds, hybridization at 55 ℃ for 1 minute, and extension with VentDNA polymerase at 72 ℃ for 2 minutes. The conditions for using the primers listed in the table are given in table 1.
Transformation and selection of transformants
A single PCR product was thus amplified and then digested with BamHI and XhoI in a 20. mu.l reaction volume for 2 hours at 37 ℃. The digestion product was ligated to similarly cleaved pET28a (Novagen), which was dephosphorylated prior to ligation by treatment with calf intestinal alkaline phosphatase (CIP). The gene fusion constructed in this way allows one-step purification of the resulting fusion protein, since the histidine residue encoded by the vector is present at the N-terminus of the fusion protein.
The ligation reaction (20. mu.l) was carried out overnight at 14 ℃ and then used to transform 100. mu.l of fresh E.coli XL1-blue competent cells (Novagen). The cells were incubated on ice for 2 hours, heat-shocked at 42 ℃ for 30 seconds, and placed back on ice for 90 seconds. The sample was added to 1ml of LB medium and grown at 37 ℃ for 2 hours without selection. The cells were plated as 10 Xpure dilutions on LB agar containing kanamycin (50. mu.l/ml) and cultured overnight at 37 ℃. The next day, 50 colonies were picked, plated on secondary plates, and cultured overnight at 37 ℃.
5 colonies were picked, grown in 3ml of LB medium supplemented with kanamycin (10. mu.l/ml) and cultured overnight at 37 ℃. Plasmid DNA was extracted by Quiagen miniprep and quantified by agarose gel electrophoresis. PCR was performed under the above conditions using gene-specific primers, and it was confirmed that the transformed DNA contained the desired insert. If the PCR is positive, one of the 5 plasmid DNA samples (500ng) isolated from E.coli XL1-blue cells was used to transform competent BL21 (. lamda.DE 3) E.coli competent cells (Novagen; as described above). Transformants (10) were selected, plated on selective LB agar plates containing kanamycin (50. mu.l/ml) and stored as study stocks in LB containing 50% glycerol.
Purification of recombinant proteins
1ml of frozen glycerol stock prepared as described in 2.C. was used to inoculate 50ml of LB medium containing 25. mu.g/ml kanamycin in a 250ml Erlenmeyer flask. The flask was incubated at 37 ℃ for 2 hours or until the absorbance (OD) at a wavelength of 600nm600) To 0.4-1.0. The growth of the culture was terminated by placing the flask at 4 ℃ overnight. The next day, 10ml of overnight culture was used to inoculate 240ml of LB medium containing kanamycin (25. mu.g/ml), the starting OD of which600About 0.02-0.04. Each ORF was inoculated in 4 flasks. Allowing the cells to grow to OD600Is 1.0(37 ℃, approximately 2 hours) and a 1ml sample is collected by centrifugation and then analyzed by SDS-PAGE to detect any leaky expression. The remaining cultures were induced with 1mM IPTG and the induced cultures were grown for an additional 2 hours at 37 ℃.
Obtaining the final OD600Read and recover the cells by centrifugation at 5,000 Xg for 15 minutes at 4 ℃. The supernatant was discarded and the pellet resuspended at 50mM (pH8.0), 2mM EDTA. 250ml of the buffer was used for each 1L of the culture, and the cells were recovered by centrifugation at 12,000 Xg for 20 minutes. The supernatant was discarded and the precipitate was stored at-45 ℃.
Protein purification
The pellet obtained by the method described in 2. D.was thawed and resuspended in 95ml of 50mM (pH 8.0). Pefabloc and lysozyme were added at final concentrations of 100. mu.M and 100. mu.g/ml, respectively. The mixture was homogenized by magnetic stirring at 5 ℃ for 30 minutes. In the presence of 10mM At a final concentration of 1U/ml, Benzonase (Merck) was added toensure complete digestion of the DNA. The suspension was sonicated for 3 cycles of 2 minutes (Branson Sonifier450), each at maximum output power. The homogenate was centrifuged at 19,000 Xg for 15 minutes and the supernatant and pellet were analyzed by SDS-PAGE to detect the cellular location of the target protein in soluble or insoluble fractions, as will be further explained below.
Soluble component of E.1
If the target protein is produced in soluble form (i.e.present in the form described in 2. E.)In the supernatant obtained by the method), sodium chloride and imidazole were added to the supernatant to a final concentration of 50mM (pH8.0), 0.5M sodium chloride and 10mM imidazole (buffer A). The mixture was filtered through a 0.45 μm membrane and loaded onto a MIAC column (pharmacia HiTrap chelate Sepharose; 1ml) which had been loaded with nickel ions according to the manufacturer's recommendations. After loading, the column was washed with 50 column volumes of buffer A and 5ml of buffer B (50 mM) (pH8.0), 0.5M sodium chloride, 500mM imidazole) to elute the recombinant protein.
The elution profile was monitored by measuring the absorbance of this component at a wavelength of 280 nm. Fractions corresponding to the protein peak were collected, dialyzed against PBS containing 0.5M arginine, filtered through a 0.22 μ M membrane, and stored at-45 ℃.
E.2. insoluble component
If the target protein is expressed in an insoluble fraction (precipitate obtained by the method described in 2. E.), purification is carried out under denaturing conditions. Sodium chloride, imidazole, and urea were added to the resuspended pellet to a final concentration of 50mM (pH8.0), 0.5M sodium chloride, 10mM imidazole, and 6M urea (buffer C). After complete dissolution, the mixture was filtered through a 0.45 μm membrane and loaded onto an IMAC column. The purification procedure performed on an IMAC column was the same as that described in 2.e.1, except that 6M urea was contained in all buffers used and that the column was washed with 10 column volumes instead of 50 column volumes of buffer C after protein loading.
The protein fractions eluted from the IMAC column with buffer D (buffer C containing 500mM imidazole) were collected. Arginine was added to the solution at a final concentration of 0.5M and the mixture was dialyzed against PBS containing 0.5M arginine and various concentrations of urea (4M, 3M, 2M, 1M and 0.5M) to gradually reduce the concentration of urea, and the final dialysate was filtered through a 0.22 μ M membrane and stored at-45 ℃.
In addition, when the above purification method is not as effective as desired, the following two other methods may be employed. The first alternative involves the use of a mild denaturant, N-octyl glucoside (NOG). Briefly, the pellet obtained by the method described in 2.E. was homogenized in a medium containing 5mM imidazole, 500mM sodium chloride, and 20mM by microfluidization at a pressure of 15,000psi (pH7.9) and clarified by centrifugation at a speed of 5,000 Xg and 4,000-. The precipitate was recovered, resuspended in 50mM sodium phosphate (pH7.5) containing 1-2% w/v NOG, and homogenized. NOG-soluble impurities were removed by centrifugation. The precipitate was extracted 1 more time by repeating the above extraction steps. Dissolving the precipitate in 8MUrea, 50mM Tris (pH8.0). Urea-solubilized protein was diluted with an equal volume of 2M arginine, 50mM Tris (pH8.0) and dialyzed against 1M arginine for 24-48 hours to remove urea. Thefinal dialysate was filtered through a 0.22 μm membrane and stored at-45 ℃.
A second alternative consists in using a strongly denaturing agent such as guanidine hydrochloride. Briefly, the pellet obtained by the method described in 2.E. was homogenized in a medium containing 5mM imidazole, 500mM sodium chloride, and 20mM by microfluidization at a pressure of 15,000psi (pH7.9) and clarified by centrifugation at a speed of 5,000 Xg and 4,000-. Recovering the precipitate, resuspending in 6M guanidine hydrochloride, and passing through the column IMAC column of (4). Bound antigen was eluted with 8M urea (pH 8.5). Lambda-mercaptoethanol was added to the eluted protein at a concentration of 1M, and the eluted protein was then passed through a SephadexG-25 column equilibrated with 0.1M acetic acid. The protein eluted from the column was slowly added to a 4-fold volume of 50mM Buffer (ph7.0) while the protein remains in solution.
Evaluation of the protective Activity of the purified proteins
A group OF 10 OF1 mice (IFFA Credo) was immunized by the rectal route with 25 μ g OF purified recombinant protein mixed with 1 μ g OF cholera toxin (Berna) in physiological buffer. Mice were immunized on days 0, 7, 14 and 21. After 14 days of the last immunization, the mice were stimulated with the H.pylori strain ORV2001 grown in liquid medium (cells on agar plates grown as described in 2.A. and resuspended in Brucella broth after harvest; these flasks were then cultured overnight at 37 ℃). At 14 days after stimulation, the mice were sacrificed and their stomachs were removed. The amount of helicobacter pylori was determined by measuring the urease activity in the stomach and by culturing.
Production of monospecific polyclonal antibodies
G.1 hyperimmune Rabbit antiserum
New Zealand rabbits were injected subcutaneously and intramuscularly with 100. mu.g of the purified fusion polypeptide obtained by the method described in 2.E.1. or 2.E.2. containing Freund's complete adjuvant in a total volume of about 2 ml. At 21 and 42 days after the initial injection, booster doses at the same dose as the priming dose were administered in the same manner, except that Freund's incomplete adjuvant was used. 15 days after the last injection, animal sera were recovered, decomplemented, and filtered through a 0.45 μm membrane.
Hyperimmune ascites in mice
10-50. mu.g of purified fusion polypeptide obtained by the method described in 2.G.1. or 2.G.2. containing Freund's complete adjuvant in a volume of about 200. mu.l was injected subcutaneously into 10 mice. Booster doses, identical to the priming dose except that Freund's incomplete adjuvant was used, were administered in the same manner 7 and 14 days after the initial injection. After 21 and 28 days of the initial injection, mice received 50 μ g of antigen alone by the intraperitoneal route. On day 21, mice were also injected intraperitoneally with sarcoma 180/TG cells CM26684(Lennette et al, diagnostic of viral, rickettsial, and chlamydial infections, 5th edition, Washington D.C., American society for public health, 1979). Ascites were collected 10-13 days after the last injection.
Example 3: methods for producing transcriptional fusions lacking a histidine tag
Methods for amplifying and cloning polypeptides encoding the histidine-tag-deficient transcriptional fusion forms of the invention are described below. Two PCR primers are designed for each clone based on the sequence of the polynucleotide encoding them (see appended sequence Listing (odd numbered, up to sequence 1363.) these primers can be used to amplify DNA encoding the polypeptide of the present invention which is derived from all strains of H.pylori, e.g., including ORV2001 and the strain deposited with ATCC under accession number 43579, and can be derived from other helicobacter.the N-terminal primer is designed to include the ribosome binding site, ATG initiation site, and any signal sequence and cleavage site of the target gene, the N-terminal primer can include a 5' clamp and a restriction enzyme recognition site, such as a site recognizing BamHI (GGATCC), which facilitates subsequent cloning. similarly, the C-terminal primer can include a restriction enzyme recognition site, such as a site recognizing XhoI (CTCGAG), this site is available for subsequent cloning and also includes a TAA stop codon.
The gene encoding the polypeptide of the invention can be amplified using Thermalase DNA polymerase under the conditions described in example 2. Alternatively, VentDNA (new england laboratories), Pwo DNA polymerase (Boehringer Mannheim), or Taq DNA polymerase (Appligene) may be used following the instructions provided by the manufacturer.
A single PCR product from each clone was amplified and cloned into appropriately cleaved pET24 (e.g., BamHI-XhoI cleaved pET24) to construct a transcriptional fusion that was capable of expressing a protein without a histidine tag. The expressed product can be purified as a denatured protein and refolded by dialysis into 1M arginine.
After cloning into pET24, the gene can be transcribed from the T7 promoter, which is supplied by the vector but relies on the binding of RNA-specific DNA polymerase to the gene's internal ribosome binding site and thus the expression of the complete ORF. Amplification, digestion, and cloning protocols that can be used in this method are the same as those used above for the construction of translational fusions.
Example 4: purification of the Polypeptides of the invention by immunoaffinity
A. purification of specific IgGs
Immune serum prepared according to the method described in section 2.G. (pH8.0) in an equilibrated Sepharose fast flow column (Pharmacia). By mixing 10 column volumes of 100mM And 10 volumes of 10mM (pH8.0) was added to the column to wash the resin. The IgG antibody was eluted with 0.1M glycine buffer (pH3.0), and 5ml of fractions were collected, to each of which 0.25ml of 1M was added (pH8.0). Measuring the optical density of the eluate at 280nm and combining the IgG antibody-containing fractions with 50mM (pH8.0) dialyzed, if necessary, by cryopreservation at-70 ℃.
Preparation of column B
An appropriate amount of CNBr-activated Sepharose 4B gel (1g of dried gel provides about 3.5ml of hydrated gel; gel content; CNBr-activated Sepharose 4B gel from Pharmacia)Amount of 5-10mg conjugated IgG/ml gel) suspended in 1mM In buffer, and by adding a small amount of 1mM The buffer was washed with a buchner funnel. The total volume of buffer per gram of gel was 200 ml.
The purified IgG antibody was dialyzed against a 50-fold volume of 500mM sodium phosphate buffer (pH7.5) at 20. + -. 5 ℃ for 4 hours. The antibody was then diluted at 500mM The final concentration of thebuffer solution (pH7.5) was 3 mg/ml.
IgG antibodies were mixed with the gel overnight at 5. + -. 3 ℃. The gel was packed into a chromatography column and used at 50mM for 2 column volumes The buffer (pH7.5) and 1 column volume of 50mM sodium phosphate buffer containing 500mM sodium chloride (pH 7.5). The gel was then transferred to a tube, mixed with 100mM ethanolamine (pH7.5) for 4 hours at room temperature, and washed twice with 2 column volumes of PBS. The gel was then stored in 1/10,000 PBS/thimerosal. The amount of IgG antibody conjugated to the gel was determined by measuring the IgG solution and the direct eluate, plus the Optical Density (OD) of the wash solution at a wavelength of 280 nm.
Adsorption and elution of C. antigens
A supernatant such as that obtained by the method described in 3.E. is dissolved in 50mM at a flow rate of about 10 ml/hour (pH8.0), dissolved precipitate in 2mM EDTAAntigen solution, after centrifugation and filtration through a 0.45 μm membrane, was loaded with 50mM (pH8.0), 2mM EDTA equilibrated in the column. Then 50mM in 20 volumes (pH8.0), the column was washed with 2mM EDTA. Alternatively, adsorption can be achieved by mixing overnight at 5 ± 3 ℃.
The pipette is washed with 2-6 volumes of 10mM sodium phosphate buffer (pH6.8)The gel was attached, and the antigen was eluted with 100mM glycine buffer (pH 2.5). The eluate was recovered in 3ml fractions, and 150. mu.l of 1M sodium phosphate buffer (pHS.0) was added to each fraction. Measuring the absorbance of each component at a wavelength of 280 nm; the fractions containing the antigen were pooled andstored at-20 ℃.
ORF HP_ GHP_ Priority oligo 5′ oligo 3′ pcR Condition
PMO TIGR Dén.inrl Dán Hyb Elong Elong fin Number of rounds Polymerase enzyme
43 147 July CTGAATTCGAATGAAAAGAATTTTAGTCTCT CCGCTCGAGTTAAAACTCATAATTCAAAT - 97/30″ 55/1′ 72/2′30″ - 25 Vent
24* 282 Apr GCGGATCCAGAAAGGTTATCACAATG CCGCTCGAGTCACATACGCTGTGATG 94/5′ 94/30″ 50/30″ 72/1′ 72/7′ 30 Vent
12 359 Apr CGCGGATCCGAATTAAGGAGAGTTGTTGGATG CCGCTCGAGCTACCATTTGTAAGCCACTTC - 97/30″ 50/1′ 72/2′30″ - 25 Vent
123 409 June CGCGGATCCGAATGTGGAATTTTAACACC CCGCTCGAGTTAAAACTTATAGGAAATTTC - 97/20″ 55/40″ 72/1′30″ - 25 Taq
124 422 June CGCGGATCCGAATGAATTTAAATTTTATG CCGCTCGAGTCAAAATTCGTCATTATTTTC - 97/20″ 55/40″ 72/1′30″ - 25 Taq
121 430 June CTGAATTCGAATGAAACTCCCGGTCGTTGAG CCGCTCGAGTTAAAACCCTTTTTGATTATC - 97/20″ 55/40″ 72/1′30″ - 25 Taq
46 442 Apr CTGAATTCGAATGAAAAAAGAGGTCGTG CCGCTCGAGTTAATCCCTAAAAAATGCA - 97/30″ 55/45″ 72/1′30″ - 25 Vent
47 445 Apr CGCGGATCCGACTCAGTGGTAGAGCACGA CCGCTCGAGCTAGTCGCCTTGAACGAT - 97/30″ 55/45″ 72/1′30″ - 25 Vent
122 446 June CGCGGATCCGAATGGTGGTTTTTACTAAAAG CCGCTCGAGTCAAGTTTTTAGATTTTCACC - 97/20″ 55/40″ 72/1′30″ - 25 Taq
125 447 June CGCGGATCCGAATTTCCTTATCTGTTAAACA CCGCTCGAGTTAAAAACGCACCACCATAGT - 97/30″ 55/50″ 72/1′30″ - 25 Vent
126 450 June CGCGGATCCGAATGCGTTGCGTGGTGTAT CCGCTCGAGCTATTTATGGTATGGATGCTT - 97/30″ 55/50″ 72/1′30″ - 25 Vent
127 451 June CGCGGATCCGAATGGGATTTGCAGATTTC CCGCTCGAGTTAAAAAATCTTTGAAGTCTT - 97/30″ 55/50″ 72/1′30″ - 25 Vent
128 452 June CGCGGATCCGAATGCAAGGGTTTCTTTTAC CCGCTCGAGTCAAAACCCTAAATTCAGCGT - 97/30″ 55/50″ 72/1′30″ - 25 Vent
48 454 Apr CGCGGATCCGAATGGTTTTAATCGCTCTT CCGCTCGAGCTACCTTAACGCACAAAC - 97/30″ 55/45″ 72/1′30″ - 25 Vent
129 456 June CGCGGATCCGAATGAACGCTTGGAATACG CCGCTCGAGTCATTGATTTTCCTTTATTTTTTTAG - 97/30″ 55/50″ 72/1′30″ - 25 Vent
130 461 June CGCGGATCCGAATGCAAGATTTTTCAAGT CCGCTCGAGTTAACTAACGCCATTTTCAGC - 97/30″ 55/50″ 72/1′30″ - 25 Vent
131 476 June CGCGGATCCGAATGGCGCAAAAAACTCTT CCGCTCGAGTTAAAATAGGGGTTCGACCTA - 97/30″ 55/50″ 72/1′30″ - 25 Vent
132 478 June CGCGGATCCGAATGAATTTTCAAGAAAAT CCGCTCGAGTCAGCCTTTTCTTAACTCATC - 97/30″ 55/50″ 72/2′ - 25 Vent
52 479 Apr CGCGGATCCGATTTTTTAAAGGGATTAGA CCGCTCGAGTTATTGAATGTATTTGAC - 97/30″ 55/45″ 72/1′30″ - 25 Vent
53 480 Apr CGCGGATCCGAATGCAAGGGGAAATCATG CCGCTCGAGTTAAAAGAATTTAGAAAT - 97/30″ 55/45″ 72/1′30″ - 25 Vent
196 483 CGCGGATCCGACCACATTTCAGGGAAGCG CCGCTCGAGCTAGCCAAATAGTATCCATAG - 97/30″ 55/50″ 72/1′30″ - 25 Vent
134 511 June CGCGGATCCGAAGACATAGAAACAGAGCT CCGCTCGAGTTAAAAATCCATTCCATAG - 97/20″ 55/40″ 72/1′30″ - 25 Taq
55 515 Apr CGCGGATCCGACAAGGGGTGGTTTCACTG CCGCTCGAGTCAAAACACTTCTTCATTG - 97/30″ 55/45″ 72/1′30″ - 25 Vent
198 517 July CGCGGATCCGAAGACTTCCCCCTAATTTTAAAG CCGCTCGAGTTACTCGTATATTGTGGG - 97/30″ 55/1′ 72/1′ - 25 Vent
135 519 June CGCGGATCCGAATGAAAAAAATTGATGAT CCGCTCGAGTTAATGCGGTGTTTCTTGATC - 97/20″ 55/40″ 72/1′30″ - 25 Taq
56 523 Apr CGCGGATCCGATTTAAAGGATTTCTATTG CCGCTCGAGTTAAAAGGTTTTAAGGGC - 97/30″ 55/45″ 72/1′30″ - 25 Vent
137 526 June CGCGGATCCGAATGCAATTTCATTCATCT CCGCTCGAGTCATGCAATTACCTCATATTG - 97/20″ 55/40″ 72/1′30″ - 25 Taq
138 534 June CGCGGATCCGAATGCTTTTGATCGTT CCGCTCGAGTTATATCAAATCTTTTTTG - 97/30″ 55/1′ 72/1′30″ - 25 Vent
59 541 Apr CGCGGATCCGAATGCAATATAAGAAAAAT CCGCTCGAGTTAAAACAAAAACTTCCC - 97/30″ 55/45″ 72/1′30″ - 25 Vent
139 542 June CGCGGATCCGAATGAGTAAGAGTTTATAC CCGCTCGAGTTACAATTCTTTTTCTAATAAC - 97/30″ 55/1′ 72/1′ - 25 Vent
140 544 June CGCGGATCCGAATGAGCCTGACTTCGC CCGCTCGAGTCAATTTCTTATCTTATCAAG - 97/30″ 52/1′ 72/1′30″ - 25 Vent
60 551 Apr CGCGGATCCGAATGAAAGTGCAAAATTTT CCGCTCGAGCTATTTTCCATCATCAAA - 97/30″ 55/45″ 72/1′30″ - 25 Vent
61 558 Apr CGCGGATCCGATTTTTATCGGTTTTAGGG CCGCTCGAGCTAAAAAGCACTTTTATC - 97/30″ 55/45″ 72/1′30″ - 25 Vent
201 561 July CGCGGATCCGAATGATGCAAGTTTACCAC CCGCTCGAGTTAAGCGTTGTTGAAGATTTC - 97/30″ 55/1′ 72/1′30″ - 25 Vent
62 563 Apr CGCGGATCCGAGTAGAACATTATGACTAC CCGCTCGAGCTAAGCTTGATTTTTAGG - 97/30″ 55/45″ 72/1′30″ - 25 Vent
141 576 June CGCGGATCCGAATGGGGTTTTATGCAGGA CCGCTCGAGTTAGAACACATATTGATACCC - 97/30″ 55/1′ 72/1′ - 25 Vent
142 578 June CGCGGATCCGAATGAAAGAACGGATAGTCA CCGCTCGAGTTAAAATAAAGTTTGGGGGTT - 97/30″ 55/1′ 72/1′30″ - 25 Vent
143 580 June CGCGGATCCGAATGTTTGAAGATTTAAAAC CCGCTCGAGCTACGACTCGCTCTTTGTATT - 97/30″ 55/1′ 72/1′30″ - 25 Vent
144 585 June CGCGGATCCGAATGAGTTTTTTAAATATTTTAAATG CCGCTCGAGTTAAAAATGCCACGAATGCGA - 97/30″ 55/1′ 72/1′ - 25 Vent
145 599 June CGCGGATCCGAATGGCAGATAAAGAAATAC CCGCTCGAGTTAGAAAATTTTAGGATTTGT - 97/30″ 55/1′ 72/1′30″ - 25 Vent
65 602 Apr CGCGGATCCGAATGAAAAAGATTGCATTT CCGCTCGAGTCATCTCTTTTCGTTCAA - 97/30″ 55/45″ 72/1′30″ - 25 Vent
66 607 Apr GGGAATTCAAAAATAGCACGCC CCGCTCGAGTTAGAATTTAGCGC 94/5′ 94/30″ 55/30″ 72/1′ 72/7′ 25 Vent
67 610 Apr GGGGAATTCGGCTTGAAAAATCTC CCGCTCGAGTTAAAATTGAGGTAG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 25 Vent
19 615 July CGCGGATCCGAAGACATGTGCAACCGATG CCGCTCGAGCTAAAAGTTTTGCAAAATCAC - 97/30″ 55/1′ 72/2′ - 25 Vent
68 616 Apr GGGAATTCGGGGTTACTGGGCTAAAG CCGCTCGAGTTACCCTAAAAGAAAC 94/5′ 94/30″ 45/30″ 72/30″ 72/7′ 25 Vent
204 625 CGCGGATCCGAAGGGTGCGCGACTTAGG CCGCTCGAGCTAAATTGAAACACCCTCCGC - 97/30″ 55/1′ 72/1′ - 25 Vent
14 626 Apr CGCGGATCCGACAAAAAGATCATGGCATTTTG CCGCTCGAGCTAAGTCGCGCACCCTTCAGC - 97/30″ 55/45″ 72/1′30″ - 25 Vent
205 633 July CGCGGATCCGAATGACTTCAGCTTCAAGC CCGCTCGAGCTAGCTCTTTTTTAAGAG - 97/30″ 55/1′ 72/1′30″ - 25 Vent
69 635 Apr GGGAATTCAATAAAACAACGGTT CCGCTCGAGCTAAAAATTATAGAT 94/5′ 94/30″ 45/30″ 72/30″ 72/7′ 30 Vent
146 639 June CGCGGATCCGAATGGCAAAAAGTATTGAAT CCGCTCGAGTTAAAAAAAGCTCATTTTAGG - 97/30″ 55/1′ 72/1′30″ - 25 Vent
147 642 June CTGAATTCGAGTTTTAAGGGGTTTTTTGAA CCGCTCGAGTTAAAAAATATAAGTGTAGTT - 97/30″ 55/1′ 72/1′ - 25 Vent
70 646 Apr GCGGATCCGGATACGCAAGCAAATTAG CCCCTCGAGTTATCGGCTTGAAGTG 94/5′ 94/30″ 45/30″ 72/30″ 72/7′ 30 Vent
148 647 June GGAATTCGAATGAGACGGAGTTTTTTGAAA CCGCTCGAGTTAAAATTCTTTCCTTGGAT - 97/30″ 55/1′ 72/1′30″ - 25 Vent
149 654 June CGCGGATCCGAATGCAAAACCATGATTTA CCGCTCGAGCTACCCATGCGAACATGAGCA - 97/30″ 55/1′ 72/1′ - 25 Vent
72 655 Apr GGGAATTCAAAAGGCTTTTTTTTATCCC CCGCTCGAGTCATGGTTTTGCATGGTG 94/5′ 94/30″ 55/30″ 72/30″ 72/7′ 30 Vent
150 669 June CGCGGATCCGAATCTCTTCTAAGCGTTTGG CCGCTCGAGTCAAGAGTTTGAAGCGTTTGC - 97/20″ 55/40″ 72/1′30″ - 25 Taq
73 670 Apr GGGAATTCAATATATCGGTTAACCCC CCGCTCGAGTCAACTCCCTAAACC 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 20 Vent
74 675 Apr GGGAATTCAGCGTGAATAGTAATGG CCGCTCGAGTTACTTCATTCTCATC 94/5′ 94/30″ 55/30″ 72/1′ 72/7′ 25 Vent
34 678 Apr CGCGGATCCGAAGACAAAGAAGTCTTGATCTA CCGCTCGAGTTAGTTCTTCTTAAAGAGTTG - 97/30″ 55/45″ 72/1′30″ - 25 Vent
75 690 Apr GCGGATCCATAAAAAAAGCTAG CCCCTCGAGTTAAAACCCCATGATG 94/5′ 94/30″ 50/30″ 72/1′ 72/7′ 25 E×Taq
76 695 Apr GCGGATCCGGTGAAACGTACGCC CCCCTCGAGTTAAAAACCCATTTTG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
77 699 GCGGATCCTTAAGGAAAAACATTTTAG CCCCTCGAGTCACTCATCAAACGG 94/5′ 94/30″ 50/30″ 72/1′ 72/7′ 25 Vent
78 701 Apr GCGGATCCAAAAAGCAAGTCAG CCCCTCGAGTCAAAAAGATGCTAC 94/5′ 94/30″ 50/30″ 72/1′ 72/7′ 25 Vent
79 702 Apr GCGGAATTCATTAAACAATCATTAAATG CCCCTCGAGTCAAGAGGCTTTGATG 94/5′ 94/30″ 50/30″ 72/1′ 72/7′ 25 ExTaq
39 708 Apr GGAATTCGCACAAACACTTTG CCGCTCGAGTTAGGAGTTTTCTTC 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 20 Vent
81 709 Apr GGGAATTCCAAAAAAACTTCTAAC CCCCTCGAGTTAGCACCAAGAATG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 25 Vent
151 710 June CGCGGATCCGAATGGGGTTTTTCAAGCTTA CCGCTCGAGTTAACGAAAGATAAATACAG - 97/20″ 55/40″ 72/1′30″ - 25 Taq
152 713 June CGCGGATCCGAATGACCCCTCACATCAACG CCGCTCGAGCTAACTCATCATCTCCAAAGC - 97/20″ 55/40″ 72/1′30″ - 25 Taq
153 716 June CGCGGATCCGAATGTTTAAGAAAATTTTTC CCGCTCGAGTTATTTTCTAAAGTTTTGCGC - 97/20″ 55/40″ 72/1′30″ - 25 Taq
154 718 June CGCGGATCCCATGCAGAATTTTTC CCCCTCGAGTCAAGCTTTTTTGTTG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
155 726 June CGCGGATCCAAGAGAGTTAGAGAAC CCCCTCGAGTCAGCAAATATTTTTTTG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
40 731 Apr GGAATTCGGCATGACTTATGGG CCGCTCGAGCTACCACAACCTTGTC 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 20 Vent
156 734 June CGCGGATCCCAAAATGGCGTTTTG CCCCTCGAGTCAGCCTTTGCGCTTTTC 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
157 740 June CGCGGATCCTTTTTAGGCAACCCG CCCCTCGAGTCAAAATATCTCACG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
35 759 Apr GGGGATCCATTTGAATACGGAT GGAATTCTTAATGTTCCTTTTT 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 25 Vent
87 762 Apr GGGAATTCCACTCTCCAAATTTAG CCCCTCGAGTTAAAACAATACCAAAAG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 25 Vent
158 770 June CGCGGATCCGGGGCTGGGGCTGTG CCCCTCGAGTCATAACAGCCACAAAG 94/5′ 94/30″ 45/60″ 72/60″ 72/7′ 30 Vent
159 782 June CGCGGATCCGTCTCTCTCTATTTAG CCCCTCGAGCTAAAAATCCTTTAAC 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
160 786 June CGCGGATCCGATATTCGCAACGAA CCCCTCGAGTCATCCCTCTAAAGC 94/5′ 94/30″ 50/60″ 72/60″ 72/7′ 30 Vent
161 792 June CGCGGATCCTTTAATAAAGTGATTATG CCCCTCGAGTTAAAAGGGGATTTC 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
162 797 June CGCGGATCCAAATTAAAATCTTTT CCCCTCGAGTCAAAAAACACTTCG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
88 798 Apr GGGAATTCAAAACTGAGATGAAATC CCCCTCGAGTCATTCAGCCTTTTTTAAAAG 94/5′ 94/30″ 50/30″ 72/1′ 72/7′ 25 Vent
206 808 July CGCGGATCCGAATGGCTTGTGGGAAAGGG CCGCTCGAGTTAAGAAGCCATTTCTATGAG - 97/30″ 55/1′ 72/1′ - 25 Vent
163 816 June CGCGGATCCAGCGCTTATATCATTG CCCCTCGAGTTAAATTAAAATGATAATG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
91 827 AP^r CGCGGATCCGAATGAGGTATCAAAACATG CCGCTCGAGTTAAAAAATCATTCCTCCT - 97/30″ 55/1′ 72/1′30″ - 25 Vent
164 828 June CGCGGATCCTTGAAAGATGAAAAATTC CCCCTCGAGTCATTTTAAACCTCC 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
92 829 Apr CGCGGATCCGAATGCCTAGCGTGTTAGAA CCGCTCGAGTTAATACTCTCTTAAAATTC - 97/30″ 55/1′ 72/1′30″ - 25 Vent
93 836 Apr CGCGGATCCGAATGAAAAAAGCGTTAATA CCGCTCGAGTTATTGGGCGTAAGCTTCTAG - 97/30″ 55/1′ 72/1′30″ - 25 Vent
165 839 June CGCGGATCCAATGTCAAAAATCGTTTG CCCCTCGAGTCACCACCCTAATTTAG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 25 Vent
20 840 June CGCGGATCCGAGGAAATAGCATGTTAATAACC CCGCTCGAGTCACTGCTTGCATGACTTATTCCA - 97/30″ 55/1′ 72/2′ - 25 Vent
208 841 July CGCGGATCCGAATGCAAGCAGTGATTTTA CCGCTCGAGTTATAAGAATTTTTGATACAC - 97/30″ 55/1′ 72/1′ - 25 Vent
166 842 June CGCGAATTCAGACACAAACACGGA CCCCTCGAGTCATACAAATTCAATGG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
209 846 July CGCGGATCCGAATGGCAAGGATTGCTGGTGTA CCGCTCGAGCTACTTGCTACCCACGGT - 97/30″ 55/1′ 72/1′ - 25 Vent
25 847 Apr CGCGGATCCGAAGCAGTGATTCTTACGGAGCGT CCGCTCGAGTCATTTATATCTAAAAGTTATC - 95/30″ 55/50″ 72/1′30″ - 25 Vent
94 850 Apr CGCGGATCCGAGTTGAATTTAAGTGGGGT CCGCTCGAGTTAAAAGCCTACCGCGCTTA - 97/30″ 60/1′ 72/1′30″ - 25 Vent
95 852 Apr CTGAATTCGAATGAATAAAGCTATTGCTA CCGCTCGAGTCAAAATATTATACGCATACC - 97/30″ 55/1′ 72/1′30″ - 25 Vent
96 876 Apr CGCGGATCCGAATGACTCTAGGCATTGAT CCGCTCGAGTTAAATAAGGCGTTGTTCCAC - 97/30″ 55/1′ 72/1′30″ - 25 Vent
97 881 Apr CGCGGATCCGAATGAAACGGATTTTATGG CCGCTCGAGTCAATAATCCCCATTGTTTTG - 97/30″ 55/1′ 72/1′30″ - 25 Vent
167 885 June CGCGGATCCGAATTGAGTTATTATG CCCCTCGAGTTATTTGAACCAGTC 94/5′ 94/30″ 50/1′ 72/1′ 72/7′ 30 Vent
98 886 Apr CGCGGATCCGAATGAGATTTTTTTGCTTT CCGCTCGAGCTACTCTTGCTTAAAATTTTT - 97/30″ 55/1′ 72/1′30″ - 25 Vent
168 889 June CGCGGATCCAGGGTAATGGCCAAAATTG CCCCTCGAGTTAGGCGTGTTTTTTAATG 94/5′ 94/30″ 50/1′ 72/1′30″ 72/7′ 30 Vent
99 893 Apr CGCGGATCCGAGTTGAGAAAATCCGATGT CCGCTCGAGTTACTGAGCTTGCGTGGAGAT - 97/30″ 55/1′ 72/1′ - 25 Vent
100 894 Apr CGCGGATCCGAATGAAAATTTCTCCATCT CCGCTCGAGTCAGTCTTCTTTCAAGCTATA - 97/30″ 55/1″ 72/1′30″ - 25 Vent
101 895 Apr CGCGGATCCGAGTGGCCCCCTCAGAGGTT CCGCTCGAGCTATTTTTTACTGCGCGAAGA - 97/30″ 55/1″ 72/1′ - 25 Vent
169 903 June CGCGGATCCAAGTCAAATAAAAAG CCCCTCGAGTCATTGTTCGCTAGG 94/5′ 94/30″ 55/1′ 72/1′ 72/7′ 30 Vent
170 912 June CGCGGATCCGAGATTAGAACCTTTTTAG CCCCTCGAGTTAAGCCATTTTCATG 94/5′ 94/30″ 55/1′ 72/1′ 72/7′ 30 Vent
102 937 Apr CGCGGATCCGAATGCGTTTAAAACATTTT CCGCTCGAGCTACCAATCAAAAATTAACAC - 97/30″ 55/55″ 72/1′30″ - 25 Vent
171 946 June CGCGGATCCATAAAAATATCTTTG CCCCTCGAGTCAAAATACTAGGCA 94/5′ 94/30″ 45/1′ 72/1′ 72/7′ 30 Vent
172 958 June CGCGGATCCGCAAAAATTGAAAGC CCCCTCGAGCTAGAAGTTACCGGA 94/5′ 94/30″ 55/1′ 72/1′ 72/7′ 30 Vent
44 961 July CGCGGATCCGATTTTACTTGAAAAATTTAAAC CCGCTCGAGTTAGAAAGTGTAGTTCAAATAC - 97/30″ 55/1′ 72/2′30″ - 25 Vent
173 968 June CGCGAATTCCAAGAGATTTTTTTATG CCCCTCGAGTTAATGACAGCTTGTCG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 25 Vent
103 976 Apr CGCGGATCCGAACGCTTATAAAAGAGGGC CCGCTCGAGTTATCCTTTAATGCCGCTTTT - 97/30″ 55/50″ 72/1′30″ - 25 Vent
104 984 Apr CGCGGATCCGAGTGGAAGAATACAAAGAC CCGCTCGAGTCATCGCTCTTTTAAAACCTG - 97/30″ 55/1′ 72/2′30″ - 25 Vent
174 987 June CGCGGATCCAACTTACAGCTTTTTTATG CCCCTCGAGTTAAAAACGATAAAC 94/5′ 94/30″ 50/60″ 72/60″ 72/7′ 30 Vent
175 992 June CGCGAATTCACGGATAACAACCAAAAC CCCCTCGAGTCAAAAAGAATGGGCATG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 25 Vent
176 996 June CGCGGATCCCTTTTAGATTTCAGC CCCCTCGAGTCACTCCCTTAAAAAC 94/5′ 94/30″ 50/30″ 72/60″ 72/7′ 30 Vent
177 997 June CGCGGATCCTTAGAATTTATTTTA CCCCTCGAGTCAAAACACCACCG 94/5′ 94/30″ 50/30″ 72/60″ 72/7′ 30 Vent
178 1002 June CGCGGATCCGAATGGCGTTTTGGCATAAAA CCGCTCGAGTTAGGGAATGTTTGGGAA - 97/30″ 55/1′ 72/1′30″ - 25 Vent
106 1011 Apr CGCGGATCCGAATGCGAAACAATAAAACG CCGCTCGAGTTAAACCTTAATGATGTAGTA - 97/30″ 55/1′ 72/1′ - 25 Vent
107 1013 Apr CTGAATTCGAGGTTTTGGCTTTGATTTCAAT CCGCTCGAGTCATGATTTATCCATCAT - 97/30″ 55/1′ 72/1′ - 25 Vent
108 1020 Apr CGCGGATCCGATCAAGCGAAATGGCAACT CCGCTCGAGTTAAAACATACGCTTATTGCT - 97/30″ 55/1′ 72/1′ - 25 Vent
109 1024 Apr CGCGGATCCGAATGAAAAAATCCATTTTA CCGCTCGAGTCAAAAAGAGGGTTTAGGGGT - 97/30″ 55/1′ 72/1′30″ - 25 Vent
179 1026 June CGCGGATCCGAAAAATAAGGAGGAATTGTTTG CCGCTCGAGTCAAGGCGTTTTCAAATA - 97/30″ 55/1′ 72/1′30″ - 25 Vent
110 1027 Apr CGCGGATCCGAATGAGAGCTACGGCGATA CCGCTCGAGTTATTTTTTTAACGGGCTTAC - 97/30″ 55/1′ 72/1′30″ - 25 Vent
111 1031 Apr CGCGGATCCGAATGAAGACAGAGAAACAA CCGCTCGAGTTATATGTTCAACTTAGAAAA - 97/30″ 55/1′ 72/1′15″ - 25 Vent
112 1034 A/Jun CTGAATTCGAATGTTGAAAAGAATGATATTA CCGCTCGAGTTAAAAATCCCTCAAGTAACT - 97/30″ 55/1′ 72/1′30″ - 25 Vent
182 1038 June CGCGGATCCGAAGTAAGCTTGATTTTAAAAAAC CCGCTCGAGTTAAAATAACGAGTCTTTTTG - 97/30″ 55/1′ 72/1′30″ - 25 Vent
41 1050 Apr CGCGGATCCGAAGGAATGTTATGCAAGATGA CCGCTCGAGTTAAGCCTTTTGGTCTGGCGT - 95/30″ 55/50″ 72/1′30″ - 25 Vent
212 1051 July CGCGGATCCGAGGCGCCAACGATTTTAATG CCGCTCGAGTTAGTTTTTTTTAACAAGCAT - 97/30″ 55/1′ 72/1′ - 25 Vent
113 1052 Apr CGCGGATCCGAATGGGATTTTTGAATGGGG CCCCTCGAGTTAAAAAGGCTTGACAACCAC - 97/30″ 55/1′ 72/50″ - 25 Vent
183 1059 June CGCGGATCCGAGTCGTATTCGTCGCTAAT CGCGGATCCGAGTCGTATTCGTCGCTAAT - 97/30″ 55/1′ 72/1′ - 25 Vent
184 1065 June CGCGGATCCGAATGCAAGAATTCAGTTTG CCGCTCGAGTCAAAAACTGCTTAAAAG - 97/30″ 55/1′ 72/1′30″ - 25 Vent
185 1072 June CGCGGATCCGAATGCTCAATTTTATGACA CCGCTCGAGTTAAAAAGTATAAACATAGCG - 97/30″ 55/1′ 72/1′30″ - 25 Vent
186 1073 June CGCGGATCCGAATGGATGCGATTTATCCT CCGCTCGAGTTAAACAAACCACATCGTTTTG - 97/30″ 55/1′ 72/1′ - 25 Vent
115 1084 Apr CGCGGATCCGAATGAAAGCAATCTTTAGC CCGCTCGAGTTACTGAGCGGCTGAATCAAG - 97/30″ 55/1′ 72/50′ - 25 Vent
13 1085 Apr CGCGGATCCGAATAAAAAGGCTAAAAGAAATG CCGCTCGAGTTAGAACTGATAGGATACCTC - 97/30″ 50/1′ 72/2′30″ - 25 Vent
213 1087 July GGGAATTCGAATGGAAAAAATCAGCGATCTT CCGCTCGAGTTAATTCTTAAACAAAGACTC - 97/30″ 55/1′ 72/1′30″ - 25 Vent
187 1088 June CGCGGATCCGAATGGAAAAGTTATTTGAA CCGCTCGAGTTATTTGTTCTGTTGCCA - 97/30″ 55/1′ 72/1′ - 25 Vent
116 1089 Apr CGCGGATCCGAATCAAGATAATCTATCAA CCGCTCGAGCTAAAAGGGGTTTTTCAATTG - 97/30″ 55/1′ 72/50′ - 25 Vent
214 1097 July CGCGGATCCGAATGCAAAATAAAGAAATTG CCGCTCGAGTCAAACCATTAAATAACC - 97/30″ 55/1′ 72/1′30″ - 25 Vent
117 1099 Apr CGCGGATCCGAATGAAATCTAAAATCACT CCGCTCGAGTTAATACTTCCTGTTGAGTGG - 97/30″ 55/1′ 72/1′ - 25 Vent
30* 1101 Apr GGGGATCCTTACTAAGGGCTTTATG GGAATTCTTAAACTAATTCCAAC 94/5′ 94/30″ 45/30″ 72/30″ 72/7′ 30 Pwo
118 1102 Apr CGCGGATCCGAATGAAAAAATCCCTTTGT CCGCTCGAGTTAAACTTCGTTGAATAAATA - 97/30″ 55/1′ 72/1′30″ - 25 Vent
119 1111 Apr CGCGGATCCGAATGCTTGAAAAAGTGTTT CCGCTCGAGTTAAAATGTGGTTGGGCGAAA - 97/30″ 55/1′ 72/1′ - 25 Vent
120 1114 Apr CTGAATTCGAATGGCAGATATTCAAAGG CCGCTCGAGTTACGCTTTAGCCATCATTTTC - 97/30″ 55/1′ 72/1′ - 25 Vent
190 1115 June CGCGGATCCGAATGATCCAATCCAGCCTTTATAG CCGCTCGAGTTAACGCCGCTTTAAAGAAATTTG - 97/30″ 55/1′ 72/5′ - 25 Vent
21 1120 Apr CGCGGATCCGATTTTGTTATCGCATGAGGGCT CCGCTCGAGCTATTTTTCATTATTGAATTTCC - 97/30″ 55/1′ 72/2′ - 25 vent
26 1138 Apr GCGGATCCACTACAGACAGAAATTTG CCGCTCGAGTTAGCCTTTCGTGTATCG 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 30 Vent
191 1159 June CGCGGATCCGAATGCAACATGAAATCCCT CCGCTCGAGTTAGAACTTTTTTTGAAAAAAATTTTTTTG - 97/30″ 50/1′ 72/2′ - 25 Vent
192 1177 June CGCGGATCCGAAGAGTGAAAGCGTTTTTAG CCGCTCGAGTTAGAAGTTTTCATGACTTTTC - 97/30″ 55/50″ 72/1′30″ - 25 Vent
193 1187 June CGCGGATCCGAATGTCCGCTCATTTTTTA CCGCTCGAGTTAAAAAATTCCCATAAACCA - 97/30″ 55/50″ 72/1′30″ - 25 Vent
194 1192 June CGCGGATCCGAATGAAAAAATACAGCACT CCGCTCGAGTTAGTTTCTGTTTTTATAGTC - 97/30″ 50/1′ 72/2′ - 25 Vent
195 1195 June CGCGGATCCGAAAATGTCTTGCTCATCTT CCGCTCGAGTTACTCTTTTTTGTGTTTAAG - 97/30″ 55/50″ 72/1′30″ - 25 Vent
23 1282 July GCGGATCCTTTTCTTCAATGTTTG CCGCTCGAGTCAAAGTTTTAAACAAATTC 94/5′ 94/30″ 45/30″ 72/30″ 72/7′ 25 Vent
11 1310 Apr CGCGGATCCGAGAGTTTGGTGTGAAACGGATT CCGCTCGAGCTATTTTTCAGACTTACTAGA - 97/30″ 50/1′ 72/1′30″ - 25 Taq
31* 1320 Apr GGGGATCCTTGAAAAATACCATAGCG GGAATTCTTACTCATAAATCAC 94/5′ 94/30″ 50/30″ 72/30″ 72/7′ 25 Pwo
22 1375 Apr CGCGGATCCGATTTCTTTTTAGTGGGTCGT CCGCTCGAGTTAAAGCTCTCTTTCAGGAAG - 97/30″ 55/1′ 72/2′ - 25 Vent
5 1432 Apr CGCGGATCCGAGTGCATAACTTCCATTGGAAT CCGCTCGAGTTCTTTTTCTAGGTGTTTGTA - 97/30″ 55/45″ 72/1′ - 30 Therm
42 1608 Apr CGCGGATCCGAAAAAAGCAGTTAAAAAATTG CCGCTCGAGCTACTTTTTATTCACGCTGCT - 95/30″ 55/50″ 72/1′30″ - 25 Vent
32 1754 June CGCGGATCCGAATGAATGAAGAAAACGAT CCGCTCGAGTTAATTGCCACCTTTGGGGCT - 97/30″ 55/1′ 72/2′30″ - 25 Taq
Therm：Thermalase，Amresco
Vent: vent DNA polymerase, New England Biolabs
Pwo: pwo DNA polymerase, Boehringer Mannheim
Taq: taq DNA polymerase, appliene
ExTaq ExTaq DNA polymerase, TaKaRa
Sequence listing
(1) General information (i) applicants: MERIEX ORAVAX SOCIETE EN NOM COLLECTIF PASSTEUR
MERIEUX SERUMS ET VACCINS S.A.HUMAN GENOME
SCIENCES, INC. (ii) title of the invention: identification of the number of sequences of polynucleotide (iii) encoding a novel helicobacter polypeptide in the helicobacter genome: 1376(iv) relative address:
(A) the receiver: clark&Elbin LLP
(B) Street: 176 Federal Street
(C) City: boston, a kind of tool
(D) State: MA (MA)
(E) The state is as follows: USA
(F) And E, postcode: 02110(v) computer-readable form:
(A) media type: flexible disk
(B) A computer: IBM compatibility
(C) Operating the system: DOS
(D) Software: FastSEQ (vi) version 2.0 of Windows for current application data: (A) application No.: PCT/US98/- - - (B) filing date: classification number 4/1/day (C): (vii) prior application for data:
(A) application No.: 08/833, 457
(B) Application date: year 97, month 4, day 1 (vii) prior application data:
(A) application No.: 08/881, 227
(B) Application date: year 97, 6, 24 days (vii) prior application data:
(A) application No.: 08/902, 615
(B) Application date: 7/29 (viii) lawyer/attorney data:
(A) name: clark, Paul T.
(B) Registration number: 30, 162
(C) Document/filing number: 06132/041WO1(ix) communication data:
(A) telephone: 617-428-0200
(B) Faxing: 617-428-7045
(C) Electric transmission:
(2) data in sequence 1: (i) sequence characteristics:
(A) length: 265bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...212
(D) Other information: (xi) Description of the sequence: sequence 1: TTTTTTAGTT TGTTTTTGAG TATAATCCTA CGAAAATTTT AAGGAACGGC ATG GAG 56
Met Glu
1TTT TTG GGA CTG ATT TTA AGT CTG GCC GCT ATT TTG ATA GCG TTT AAA 104Phe Leu Gly Leu Ile Leu Ser Leu Ala Ala Ile Leu Ile Ala Phe Lys
5 10 15AAG CCT GAA AAA GAA AAT TGG GCG TTT GGG ATT TTG ATG GTG GTG TGG 152Lys Pro Glu Lys Glu Asn Trp Ala Phe Gly Ile Leu Met Val Val Trp
20 25 30TTA GTG GAG CTT ATT ATT TTT ATA GCC CAC AGC TCT AGC GTT TTG CCT 200Leu Val Glu Leu Ile Ile Phe Ile Ala His Ser Ser Ser Val Leu Pro35 40 45 50AAC ATG AAT CTA TAAGGGGGAT GCATGGATAA AGAAACCCGA TTTTACAACC TTTTT 257Asn Met Asn LeuTCTTTGGC 265
(2) Data in sequence 2:
(i) sequence characteristics:
(A) length: 54 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 2: met Glu Phe Leu Gly Leu Ile Leu Ser Leu Ala Ala Ile Leu Ile Ala 151015 Phe Lys Lys Pro Glu Lys Glu Asn Trp Ala Phe Gly Ile Leu Met Val
20 25 30Val Trp Leu Val Glu Leu Ile Ile Phe Ile Ala His Ser Ser Ser Val
35 40 45Leu Pro Asn Met Asn Leu
50
(2) Data in sequence 3: (i) sequence characteristics:
(A) length: 670bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...617
(D) Other information: (xi) Description of the sequence: and (3) sequence: CCCATAGACG ACAAAATCAA GCGGTTTTAT CAAAACCAAA AAACTTTAGA ATG AAA 56
Met Lys
1AAA ATT GCT TTC ATT TTG GCT TTA TGG GTG GGC TTG TTA GGG GCG TTT 104Lys Ile Ala Phe Ile Leu Ala Leu Trp Val Gly Leu Leu Gly Ala Phe
5 10 15GAG CCT AAA AAA AGT CAT ATT TAT TTT GGG GCT ATG GTG GGT TTA GCT 152Glu Pro Lys Lys Ser His Ile Tyr Phe Gly Ala Met Val Gly Leu Ala
20 25 30CCT ATT AAA ATA ACC CCA AAA CCG GCT AGT GAT TCT TCT TAT ACG GCT 200Pro Ile Lys Ile Thr Pro Lys Pro Ala Ser Asp Ser Ser Tyr Thr Ala35 40 45 50TTT TTA TGG GGG GCT AAA GGA GGG TAT CAA TTC GCT TTT TTT AAA GCT 248Phe Leu Trp Gly Ala Lys Gly Gly Tyr Gln Phe Ala Phe Phe Lys Ala
55 60 65CTA GCG TTA AGG GGT GAA TTT TCC TAC CTT ATG GCA ATC AAA CCC ACC 296Leu Ala Leu Arg Gly Glu Phe Ser Tyr Leu Met Ala Ile Lys Pro Thr
70 75 80GCA CTG CAC ACG ATT AAC ACT TCT TTA TTG AGC TTA AAT ATT GAT GTG 344Ala Leu His Thr Ile Asn Thr Ser Leu Leu Ser Leu Asn Ile Asp Val
85 90 95TTA AGC GAT TTT TAC ACT TAC AAA AAA TAC AGC TTT GGG GTG TAT GGG 392Leu Ser Asp Phe Tyr Thr Tyr Lys Lys Tyr Ser Phe Gly Val Tyr Gly
100 105 110GGG CTT GGG ATA GGG TAT TTT TAT CAA AGC AAC CAT TTA GGC ATG AAA 440Gly Leu Gly Ile Gly Tyr Phe Tyr Gln Ser Asn His Leu Gly Met Lys115 120 125 130AAT AGT TCG TTT ATG GGT TAT AAC GGC TTG TTT AAT GTG GGG CTT GGC 488Asn Ser Ser Phe Met Gly Tyr Asn Gly Leu Phe Asn Val Gly Leu Gly
135 140 145AGC ACG ATC GAT CGC CAC CAC CGC ATA GAG CTT GGG GCT AAA ATC CCT 536Ser Thr Ile Asp Arg His His Arg Ile Glu Leu Gly Ala Lys Ile Pro
150 155 160TTT TCA AAG ACT AGA AAT TCT TTT AAA AAT CCT TAT TTT TTA GAG AGC 584Phe Ser Lys Thr Arg Asn Ser Phe Lys Asn Pro Tyr Phe Leu Glu Ser
165 170 175GTT TTT ATC CAT GCG ACT TAT AGC TAT ATG TTT TAAGAGAGAA TAGCCTATTA 637Val Phe Ile His Ala Thr Tyr Ser Tyr Met Phe
180185 GTGGTCGTTA TCAATAAGAT AAGATCCTTA ATG 670 (670) (2) data for SEQ ID No. 4: (i) sequence characteristics:
(A) length: 189 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: and (3) sequence 4: met Lys Lys Ile Ala Phe Ile Leu Ala Leu Trp Val Gly Leu Leu Gly 151015 Ala Phe Glu Pro Lys Lys Ser His Ile Tyr Phe Gly Ala Met Val Gly
20 25 30Leu Ala Pro Ile Lys Ile Thr Pro Lys Pro Ala Ser Asp Ser Ser Tyr
35 40 45Thr Ala Phe Leu Trp Gly Ala Lys Gly Gly Tyr Gln Phe Ala Phe Phe
50 55 60Lys Ala Leu Ala Leu Arg Gly Glu Phe Ser Tyr Leu Met Ala Ile Lys65 70 75 80Pro Thr Ala Leu His Thr Ile Asn Thr Ser Leu Leu Ser Leu Asn Ile
85 90 95Asp Val Leu Ser Asp Phe Tyr Thr Tyr Lys Lys Tyr Ser Phe Gly Val
100 105 110Tyr Gly Gly Leu Gly Ile Gly Tyr Phe Tyr Gln Ser Asn His Leu Gly
115 120 125Met Lys Asn Ser Ser Phe Met Gly Tyr Asn Gly Leu Phe Asn Val Gly
130 135 140Leu Gly Ser Thr Ile Asp Arg His His Arg Ile Glu Leu Gly Ala Lys145 150 155 160Ile Pro Phe Ser Lys Thr Arg Asn Ser Phe Lys Asn Pro Tyr Phe Leu
165 170 175Glu Ser Val Phe Ile His Ala Thr Tyr Ser Tyr Met Phe
180 185
(2) Data in sequence 5:
(i) sequence characteristics:
(A) length: 434bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...380
(D) Other information:
(xi) Description of the sequence: and (5) sequence: AGCGTGAAAA AAATTGAGTT GAATCAAAAC CTGCATTAAG GATTAAAAGA ATG CTC 56
Met Leu
1AAA AAA AGT TTG TTA TTG CTT GTT TTT TTA GTC TTA CAG CTT AGC GGC 104Lys Lys Ser Leu Leu Leu Leu Val Phe Leu Val Leu Gln Leu Ser Gly
5 10 15GCT GAA GAA AAC AAT CAA GCC CCA AAA AAC ACG CCC CCT GAA TTA AAC 152Ala Glu Glu Asn Asn Gln Ala Pro Lys Asn Thr Pro Pro Glu Leu Asn
20 2530CCC GCT AAC GCT AAG GGC GCG CCA AAC TCT AAC ACC CAG ATC ACC CCT 200Pro Ala Asn Ala Lys Gly Ala Pro Asn Ser Asn Thr Gln Ile Thr Pro35 40 45 50AAA AAC GAT AAC TCT AAC CTG TTA GAC AAA TTA GGT TCG CCT GAA AAC 248Lys Asn Asp Asn Ser Asn Leu Leu Asp Lys Leu Gly Ser Pro Glu Asn
55 60 65GCT CAA ACC GAG CTT TCT GCC GGT ATT GAT TTG GCT AAA AAG GGC GAT 296Ala Gln Thr Glu Leu Ser Ala Gly Ile Asp Leu Ala Lys Lys Gly Asp
70 75 80TAT CAA GGG GCT TTC AAG CTT TTT TCC CAA TCG TGC GAT AAT GGT AAT 344Tyr Gln Gly Ala Phe Lys Leu Phe Ser Gln Ser Cys Asp Asn Gly Asn
85 90 95GCG GCC GGG TGT TTT GCA AGT GGG GGC GAT GTA TGC TAATGGGGTA GGGATC 396Ala Ala Gly Cys Phe Ala Ser Gly Gly Asp Val Cys
100 105 110CAAACCAACA GATTAAAAGC CGCTCGCTAT TATGAATG 434
(2) Data in sequence 6: (i) sequence characteristics:
(A) length: 110 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: and (3) sequence 6: met Leu Lys Lys Ser Leu Leu Leu Leu Val Phe Leu Val Leu Gln Leu 151015 Ser Gly Ala Glu Glu Asn Asn Gln Ala Pro Lys Asn Thr Pro Pro Glu
20 25 30Leu Asn Pro Ala Asn Ala Lys Gly Ala Pro Asn Ser Asn Thr Gln Ile
35 40 45Thr Pro Lys Asn Asp Asn Ser Asn Leu Leu Asp Lys Leu Gly Ser Pro
50 55 60Glu Asn Ala Gln Thr Glu Leu Ser Ala Gly Ile Asp Leu Ala Lys Lys65 70 75 80Gly Asp Tyr Gln Gly Ala Phe Lys Leu Phe Ser Gln Ser Cys Asp Asn
85 90 95Gly Asn Ala Ala Gly Cys Phe Ala Ser Gly Gly Asp Val Cys
100 105 110
(2) Data in sequence 7: (i) sequence characteristics:
(A) length: 575bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 73...522
(D) Other information: (xi) Description of the sequence: and (3) sequence 7: CCACAAAAGC TTAATGAATA TTAAATTAAA AACATGTTAA TCTTTAGTTA TTTTTAAAAT 60TTAGGAAATC CC ATG CAT CAA AAC AAT AAA ACT TTT TTA CCC AGC CAA TCC 111
Met His Gln Asn Asn Lys Thr Phe Leu Pro Ser Gln Ser
1 5 10GCT CAC CTC TCT AAA ATC ATT CTT TTT TTA AAC ACC GGC TTT TTA GCC 159Ala His Leu Ser Lys Ile Ile Leu Phe Leu Asn Thr Gly Phe Leu Ala
15 20 25TAT CTG TTA AGC GCT TGT GGG GCG AAT GTG CCT ATA GAA GAA GTG TTG 207Tyr Leu Leu Ser Ala Cys Gly Ala Asn Val Pro Ile Glu Glu Val Leu30 35 40 45GTT AAA GAT CCT AAA GAG ACC AAA GCC CAA GAA GTC GCC AGA GAA GAA 255Val Lys Asp Pro Lys Glu Thr Lys Ala Gln Glu Val Ala Arg Glu Glu
50 55 60AAG GCT ATC CAG CAA GAA AAC GCC ACT ATT GAT GCG CGC ACC ACG CCT 303Lys Ala Ile Gln Gln Glu Asn Ala Thr Ile Asp Ala Arg Thr Thr Pro
65 70 75TTA ATC AAT CGT TTC ACT AAT TAT AGC GCT TAT GGC TCT TTA AAC GGC 351Leu Ile Asn Arg Phe Thr Asn Tyr Ser Ala Tyr Gly Ser Leu Asn Gly
80 85 90TTT TAC AAT TCA GTG GAT AAT CTC AAT TCG CCC ATG CAA AAC GGG ATG 399Phe Tyr Asn Ser Val Asp Asn Leu Asn Ser Pro Met Gln Asn Gly Met
95 100 105TAT GGA GGC TAT TAC ATG CCT TAT TAT TAC ATG CCC TAT GGT TTC ATG 447Tyr Gly Gly Tyr Tyr Met Pro Tyr Tyr Tyr Met Pro Tyr Gly Phe Met110 115 120 125CCT TAT GGG TCA GGT CTT ATG CCT TAT GGG CCT TAT GGG TAT GGA GCG 495Pro Tyr Gly Ser Gly Leu Met Pro Tyr Gly Pro Tyr Gly Tyr Gly Ala
130 135 140CCT GGA TAG TTC CCT TAC GCT TTT TAT TGATTGAGTG GCTTTAGAAA GCGTGGT 549Pro Gly Tyr Phe Pro Tyr Ala Phe Tyr
145 150GGTGTTGGTG TTTTTACTCA AACACG 575
(2) Data in sequence 8: (i) sequence characteristics:
(A) length: 150 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: and (2) sequence 8: met His Gln Asn Asn Lys Thr Phe Leu Pro Ser Gln Ser Ala His Leu 151015 Ser Lys Ile Ile Leu Phe Leu Asn Thr Gly Phe Leu Ala Tyr Leu Leu
20 25 30Ser Ala Cys Gly Ala Asn Val Pro Ile Glu Glu Val LeuVal Lys Asp
35 40 45Pro Lys Glu Thr Lys Ala Gln Glu Val Ala Arg Glu Glu Lys Ala Ile
50 55 60Gln Gln Glu Asn Ala Thr Ile Asp Ala Arg Thr Thr Pro Leu Ile Asn65 70 75 80Arg Phe Thr Asn Tyr Ser Ala Tyr Gly Ser Leu Asn Gly Phe Tyr Asn
85 90 95Ser Val Asp Asn Leu Asn Ser Pro Met Gln Asn Gly Met Tyr Gly Gly
100 105 110Tyr Tyr Met Pro Tyr Tyr Tyr Met Pro Tyr Gly Phe Met Pro Tyr Gly
115 120 125Ser Gly Leu Met Pro Tyr Gly Pro Tyr Gly Tyr Gly Ala Pro Gly Tyr
130 135 140Phe Pro Tyr Ala Phe Tyr145 150
(2) Sequence 9 data:
(i) sequence characteristics:
(A) length: 910bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...860
(D) Other information:
(xi) Description of the sequence: sequence 9: ATTATGTTAT TATTATACGA AATGTAGACT TTTAGAAGGA AAAATGTTGT ATG AAA 56
Met Lys
1AAG TTT GTA GTG TTT AAA ACG CTC TGT TTA TCGGTA GTG TTA GGT AAT 104Lys Phe Val Val Phe Lys Thr Leu Cys Leu Ser Val Val Leu Gly Asn
5 10 15AGT CTT GTG GCA GCA GAA GGC AGC ACA GAA GTG CAA AAG CAA TTG GAA 152Ser Leu Val Ala Ala Glu Gly Ser Thr Glu Val Gln Lys Gln Leu Glu
20 25 30AAG CCA AAA GAG TAT AAA GCA GTG AAA GGC GAG AAA AAC GCT TGG TAT 200Lys Pro Lys Glu Tyr Lys Ala Val Lys Gly Glu Lys Asn Ala Trp Tyr35 40 45 50TTG GGG ATT AGC TAT CAA GTC GGT CAG GCT TCG CAA AGC GTT AAA AAC 248Leu Gly Ile Ser Tyr Gln Val Gly Gln Ala Ser Gln Ser Val Lys Asn
55 60 65CCC CCC AAA AGC AGT GAA TTT AAC TAC CCT AAG TTC CCT GTG GGT AAA 296Pro Pro Lys Ser Ser Glu Phe Asn Tyr Pro Lys Phe Pro Val Gly Lys
70 75 80ACC GAC TAT CTG GCC GTT ATG CAA GGC TTA GGG CTT ACT GTG GGT TAT 344Thr Asp Tyr Leu Ala Val Met Gln Gly Leu Gly Leu Thr Val Gly Tyr
85 90 95AAG CAG TTT TTC GGG GAA AAG AGA TGG TTT GGT GCA CGC TAT TAC GGC 392Lys Gln Phe Phe Gly Glu Lys Arg Trp Phe Gly Ala Arg Tyr Tyr Gly 100 105 110TTC ATG GAT TAT GGG CAT GCC GTA TTT GGA GCG AAC GCT TTA ACA TCG 440Phe Met Asp Tyr Gly His Ala Val Phe Gly Ala Asn Ala Leu Thr Ser115 120 125 130GAT AAT GGT GGG GTG TGT GAG CTT CAC CAA CCA TGT GCG ACC AAA GTA 488Asp Asn Gly Gly Val Cys Glu Leu His Gln Pro Cys Ala Thr Lys Val
135 140 145GGG ACA ATG GGC AAT CTG TCT GAC ATG TTC ACT TAT GGT GTG GGT ATT 536Gly Thr Met Gly Asn Leu Ser Asp Met Phe Thr Tyr Gly Val Gly Ile
150155 160GAC ACT TTA TAC AAT GTC ATC AAT AAA GAA GAT GCG AGT TTT GGT TTC 584Asp Thr Leu Tyr Asn Val Ile Asn Lys Glu Asp Ala Ser Phe Gly Phe
165 170 175TTT TTT GGG GCT CAA ATC GCG GGT AAC TCT TGG GGT AAT ACG ACA GGG 632Phe Phe Gly Ala Gln Ile Ala Gly Asn Ser Trp Gly Asn Thr Thr Gly
180 185 190GCC TTT TTG GAA ACT AAA AGC CCT TAT AAG CAC ACT TCC TAT AGC CTT 680Ala Phe Leu Glu Thr Lys Ser Pro Tyr Lys His Thr Ser Tyr Ser Leu195 200 205 210GAT CCG GCG ATT TTC CAG TTC CTT TTT AAT TTA GGG ATC CGC ACC CAT 728Asp Pro Ala Ile Phe Gln Phe Leu Phe Asn Leu Gly Ile Arg Thr His
215 220 225ATT GGC CGG CAT CAA GAA TTT GAC TTT GGC GTG AAG ATT CCC ACT ATC 776Ile Gly Arg His Gln Glu Phe Asp Phe Gly Val Lys Ile Pro Thr Ile
230 235 240AAT GTT TAT TAT TTT AAC CAT GGG AAT TTG AGC TTC ACT TAC CGC CGT 824Asn Val Tyr Tyr Phe Asn His Gly Asn Leu Ser Phe Thr Tyr Arg Arg
245 250 255CAA TAC AGC CTT TAT GTG GGG TAT CGT TAC AAT TTC TGATTTAAAA CGCTTG 876Gln Tyr Ser Leu Tyr Val Gly Tyr Arg Tyr Asn Phe
260 265 270TTTTTCTCTA ATTGAATTTT CAATTAGAGT TTTC 910
(2) Sequence 10 data:
(i) sequence characteristics:
(A) length: 270 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 10: met Lys Lys Phe Val Val Phe Lys Thr Leu Cys Leu Ser Val Val Leu 151015 Gly Asn Ser Leu Val Ala Ala Glu Gly Ser Thr Glu Val Gln Lys Gln
20 25 30Leu Glu Lys Pro Lys Glu Tyr Lys Ala Val Lys Gly Glu Lys Asn Ala
35 40 45Trp Tyr Leu Gly Ile Ser Tyr Gln Val Gly Gln Ala Ser Gln Ser Val
50 55 60Lys Asn Pro Pro Lys Ser Ser Glu Phe Asn Tyr Pro Lys Phe Pro Val65 70 75 80Gly Lys Thr Asp Tyr Leu Ala Val Met Gln Gly Leu Gly Leu Thr Val
85 90 95Gly Tyr Lys Gln Phe Phe Gly Glu Lys Arg Trp Phe Gly Ala Arg Tyr
100 105 110Tyr Gly Phe Met Asp Tyr Gly His Ala Val Phe Gly Ala Asn Ala Leu
115 120 125Thr Ser Asp Asn Gly Gly Val Cys Glu Leu His Gln Pro Cys Ala Thr
130 135 140Lys Val Gly Thr Met Gly Asn Leu Ser Asp Met Phe Thr Tyr Gly Val145 150 155 160Gly Ile Asp Thr Leu Tyr Asn Val Ile Asn Lys Glu Asp Ala Ser Phe
165 170 175Gly Phe Phe Phe Gly Ala Gln Ile Ala Gly Asn Ser Trp Gly Asn Thr
180 185 190Thr Gly Ala Phe Leu Glu Thr Lys Ser Pro Tyr Lys His Thr Ser Tyr
195 200 205Ser Leu Asp Pro Ala Ile Phe Gln Phe Leu Phe Asn Leu Gly Ile Arg
210 215220Thr His Ile Gly Arg His Gln Glu Phe Asp Phe Gly Val Lys Ile Pro225 230 235 240Thr Ile Asn Val Tyr Tyr Phe Asn His Gly Asn Leu Ser Phe Thr Tyr
245 250 255Arg Arg Gln Tyr Ser Leu Tyr Val Gly Tyr Arg Tyr Asn Phe
260 265 270
(2) Data for sequence 11: (i) sequence characteristics: (A) length: 1357 bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic RNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 58...1305
(D) Other information: (xi) Description of the sequence: sequence 11: CGCAATTAAA AGGAATTTTA ACTAAAATAT TGAGTTTAAA TCCACGATGA GTTTTTA ATG 60
Met
1CAA TAT AAG AAA AAT AAG AAA AGA TAT TAT TAT TTA GCG TTA GGG ATC 108Gln Tyr Lys Lys Asn Lys Lys Arg Tyr Tyr Tyr Leu Ala Leu Gly Ile
5 10 15TTT TTT TTA AAT GGT CTG TCT TTG AAA GCT TTA GAA ATC GCC GTC AAA 156Phe Phe Leu Asn Gly Leu Ser Leu Lys Ala Leu Glu Ile Ala Val Lys
20 25 30CCT TTT GGC TAT CTG GGG CTA TTA TAT AAT CAA GGG GCG CAA AAA AAC 204Pro Phe Gly Tyr Leu Gly Leu Leu Tyr Asn Gln Gly Ala Gln Lys Asn
35 40 45CCT CAC AGC TAT GTG GGG GCT TTA GCG CGT CTT GGG GTG GAT TTT TCT 252Pro His Ser Tyr Val Gly Ala LeuAla Arg Leu Gly Val Asp Phe Ser50 55 60 65TAT AGC AAC GGG TGG TCC TTT GGT ATT GGA GCG ATT GGG GCT TGG AAT 300Tyr Ser Asn Gly Trp Ser Phe Gly Ile Gly Ala Ile Gly Ala Trp Asn
70 75 80ATT TAT AAC AAA CAG CGT TTG GCT AAC CTT TAT ATC AGT CTA GGG AAT 348Ile Tyr Asn Lys Gln Arg Leu Ala Asn Leu Tyr Ile Ser Leu Gly Asn
85 90 95TTT TTT GGT AGT TCT AAA AAT GTT AAA CCT TAT TTG AGC GCT GGC GAT 396Phe Phe Gly Ser Ser Lys Asn Val Lys Pro Tyr Leu Ser Ala Gly Asp
100 105 110GTT TCT GAT GCG TAT GTT CAA TAC ACT AAC CAG CGT TTT AAA ATC GCT 444Val Ser Asp Ala Tyr Val Gln Tyr Thr Asn Gln Arg Phe Lys Ile Ala
115 120 125TTA GGG CGT TTC AAT ACC GAT TTT GTG GAT TTT GAT TGG ATA GGG GGC 492Leu Gly Arg Phe Asn Thr Asp Phe Val Asp Phe Asp Trp Ile Gly Gly130 135 140 145AAT ATT CAA GGG GTT TCT GTA GCT TTT AAG CAA AAT TCC ATG CGT TAT 540Asn Ile Gln Gly Val Ser Val Ala Phe Lys Gln Asn Ser Met Arg Tyr
150 155 160TTT GGG ATT TTT ATG GAT AGC ATG CTT TAT AAT GGG CAT CAA ATC AAC 588Phe Gly Ile Phe Met Asp Ser Met Leu Tyr Asn Gly His Gln Ile Asn
165 170 175AAA GAG CAA GGG AAT CGG ATC GCT ACT TCC CTA AAC GCT CTA GCG TCT 636Lys Glu Gln Gly Asn Arg Ile Ala Thr Ser Leu Asn Ala Leu Ala Ser
180 185 190TAT GAC CCT GTG TCT AAA CGC TTG TAT GTG GGG GGG GAA GTG TTT GTT 684Tyr Asp Pro Val Ser Lys Arg Leu Tyr Val Gly Gly Glu Val Phe Val
195 200 205TTA GGT GCA GAA TAC AGG CAT GAA AAT CTT AAA GTG GTG CCT TTT ATT 732Leu Gly Ala Glu Tyr Arg His Glu Asn Leu Lys Val Val Pro Phe Ile210 215 220 225TTA ACG GAC ACC CGC TTG CCT TTA TCC ACC CAA AAT GTT TTA GTG CAA 780Leu Thr Asp Thr Arg Leu Pro Leu Ser Thr Gln Asn Val Leu Val Gln
230 235 240GTG GGG GGT AAG TTG GAG TAT GAC GCT TCT TTA GCT AAG GGT TTC ACT 828Val Gly Gly Lys Leu Glu Tyr Asp Ala Ser Leu Ala Lys Gly Phe Thr
245 250 255TCG CAC ACT CTA GTG CAT GGC ATG TAT CAA TAC GGC AAC ACT GAT GCG 876Ser His Thr Leu Val His Gly Met Tyr Gln Tyr Gly Asn Thr Asp Ala
260 265 270GCT ACA AGC GTT AAA AAT GCC GGC TTG TTT TTG ATC GAT CAA ACT TTT 924Ala Thr Ser Val Lys Asn Ala Gly Leu Phe Leu Ile Asp Gln Thr Phe
275 280 285AAA TAC AAA ATT TTT AAT TTT GGA ACG GGT TTT TAT ATC GTT CCG GCA 972Lys Tyr Lys Ile Phe Asn Phe Gly Thr Gly Phe Tyr Ile Val Pro Ala290 295 300 305AGA AAC AAT AAG GGC TAT CTA TGG ACT TTT AAT GAC AGG ACT AAA TTC 1020Arg Asn Asn Lys Gly Tyr Leu Trp Thr Phe Asn Asp Arg Thr Lys Phe
310 315 320TAT GGC CGT GGG ATC AAT GCG CCC GGC GTG CCA GCG ATT TAT TTT GCA 1068Tyr Gly Arg Gly Ile Asn Ala Pro Gly Val Pro Ala Ile Tyr Phe Ala
325 330 335AAC TCT AGC ATT TCA GGC TAT GTT TTT TTA GGG CTT AAG ACT AAA AGG 1116Asn Ser Ser Ile Ser Gly Tyr Val Phe Leu Gly Leu Lys Thr Lys Arg
340 345 350GTG CGT TTA GAC GCG ATG GTG GCT TTT GGG GAT TAC CAA GAA TAT TCT 1164Val Arg Leu Asp Ala Met Val Ala Phe Gly Asp Tyr Gln Glu Tyr Ser
355 360 365TTA ATG AGC AGT TTT AGG GTT TGG ACT TAT AGG AGT TTG TCT TTT GAT 1212Leu Met Ser Ser Phe Arg Val Trp Thr Tyr Arg Ser Leu Ser Phe Asp370 375 380 385ATG GGT GGG GGG TAT GTG TAT GCT TAC AAT TCT AAA GCC ACG AGA AAA 1260Met Gly Gly Gly Tyr Val Tyr Ala Tyr Asn Ser Lys Ala Thr Arg Lys
390 395 400AGT CTT GGA AAT AGT TCT TTT GTC TTT TTT GGG AAG TTT TTG TTT TAAAA 1310Ser Leu Gly Asn Ser Ser Phe Val Phe Phe Gly Lys Phe Leu Phe
405 410 415AATACCATTT CTACAATCAA TAGTGAAGAG TTTGCAATAA AGTAAGC 1357
(2) Sequence 12 data: (i) sequence characteristics:
(A) length: 416 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 12: met Gln Tyr Lys Lys Asn Lys Lys Arg Tyr Tyr Tyr Leu Ala Leu Gly 151015 Ile Phe Phe Leu Asn Gly Leu Ser Leu Lys Ala Leu Glu Ile Ala Val
20 25 30Lys Pro Phe Gly Tyr Leu Gly Leu Leu Tyr Asn Gln Gly Ala Gln Lys
35 40 45Asn Pro His Ser Tyr Val Gly Ala Leu Ala Arg Leu Gly Val Asp Phe
50 55 60Ser Tyr Ser Asn Gly Trp Ser Phe Gly Ile Gly Ala Ile Gly Ala Trp65 70 75 80Asn Ile Tyr Asn Lys Gln Arg Leu Ala Asn Leu Tyr Ile Ser Leu Gly
85 90 95Asn Phe Phe Gly Ser Ser Lys Asn ValLys Pro Tyr Leu Ser Ala Gly
100 105 110Asp Val Ser Asp Ala Tyr Val Gln Tyr Thr Asn Gln Arg Phe Lys Ile
115 120 125Ala Leu Gly Arg Phe Asn Thr Asp Phe Val Asp Phe Asp Trp Ile Gly
130 135 140Gly Asn Ile Gln Gly Val Ser Val Ala Phe Lys Gln Asn Ser Met Arg145 150 155 160Tyr Phe Gly Ile Phe Met Asp Ser Met Leu Tyr Asn Gly His Gln Ile
165 170 175Asn Lys Glu Gln Gly Asn Arg Ile Ala Thr Ser Leu Asn Ala Leu Ala
180 185 190Ser Tyr Asp Pro Val Ser Lys Arg Leu Tyr Val Gly Gly Glu Val Phe
195 200 205Val Leu Gly Ala Glu Tyr Arg His Glu Asn Leu Lys Val Val Pro Phe
210 215 220Ile Leu Thr Asp Thr Arg Leu Pro Leu Ser Thr Gln Asn Val Leu Val225 230 235 240Gln Val Gly Gly Lys Leu Glu Tyr Asp Ala Ser Leu Ala Lys Gly Phe
245 250 255Thr Ser His Thr Leu Val His Gly Met Tyr Gln Tyr Gly Asn Thr Asp
260 265 270Ala Ala Thr Ser Val Lys Asn Ala Gly Leu Phe Leu Ile Asp Gln Thr
275 280 285Phe Lys Tyr Lys Ile Phe Asn Phe Gly Thr Gly Phe Tyr Ile Val Pro
290 295 300Ala Arg Asn Asn Lys Gly Tyr Leu Trp Thr Phe Asn Asp Arg Thr Lys305 310 315 320Phe Tyr Gly Arg Gly Ile Asn Ala Pro Gly Val Pro Ala Ile Tyr Phe
325 330 335Ala Asn Ser Ser Ile Ser Gly Tyr Val Phe Leu Gly Leu Lys Thr Lys
340 345 350Arg Val Arg Leu Asp Ala Met Val Ala Phe Gly Asp Tyr Gln Glu Tyr
355 360 365Ser Leu Met Ser Ser Phe Arg Val Trp Thr Tyr Arg Ser Leu Ser Phe
370 375 380Asp Met Gly Gly Gly Tyr Val Tyr Ala Tyr Asn Ser Lys Ala Thr Arg385 390 395 400Lys Ser Leu Gly Asn Ser Ser Phe Val Phe Phe Gly Lys Phe Leu Phe
405 410 415
(2) Sequence 13 data: (i) sequence characteristics:
(A) length: 1562bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 73...1509
(D) Other information: (xi) Description of the sequence: sequence 13: TTATGCTTCT TTGTTTTTAG ATCAGTTAAG AATTGTAGTC TTTAAGATGT ATTGGCTATT 60AAAAGGAAAA AA ATG AAA AAT AGC ACG CCT TTA AAG AAT CAA GTT TTT TGT 111
Met Lys ASn Ser Thr Pro Leu Lys Asn Gln Val Phe Cys
1 5 10GGG TTA TAT GTT TTA AGT TTG AGC GCT TCT TTG CAA GCG TTT GAT TAT 159Gly Leu Tyr Val Leu Ser Leu Ser Ala Ser Leu Gln Ala Phe Asp Tyr
15 20 25AAA ATT GAA GTT TCA GCG GAG TCC TTT TCT AAA GTT GGC TTT AAT AAA 207Lys Ile Glu Val Ser Ala Glu Ser Phe Ser Lys Val Gly Phe Asn Lys30 35 40 45AAA AAG ATT GAT ATA GCT AGG GGG ATT TAT CCT ACA GAG ACT TTT GTA 255Lys Lys Ile Asp Ile Ala Arg Gly Ile Tyr Pro Thr Glu Thr Phe Val
50 55 60ACC GCT GTA GGG CAG GGC AAT ATC TAT GCG GAT TTT TTA CCC AAA GGC 303Thr Ala Val Gly Gln Gly Asn Ile Tyr Ala Asp Phe Leu Pro Lys Gly
65 70 75CTT AAA GAT CAA GGG CAT GTT TTA GAG GGA AAA ATC GGT GGC ACG CTA 351Leu Lys Asp Gln Gly His Val Leu Glu Gly Lys Ile Gly Gly Thr Leu
80 85 90GGA GGG GTC GCT TAT GAT AGC ACG AAA TTC AAT CAA GGC GGA TCG GTT 399Gly Gly Val Ala Tyr Asp Ser Thr Lys Phe Asn Gln Gly Gly Ser Val
95 100 105ATT TAT AAC TAC ATC GGT TAT TGG GAT GGC TAT TTA GGG GGT AAA AGA 447Ile Tyr Asn Tyr Ile Gly Tyr Trp Asp Gly Tyr Leu Gly Gly Lys Arg110 115 120 125GCC TTG CTT GAT GGC ACG AGT ATC CAT GAG TGC GCG CTT GGA TCT GAT 495Ala Leu Leu Asp Gly Thr Ser Ile His Glu Cys Ala Leu Gly Ser Asp
130 135 140GGC AAG GTG ATT GAT TCT ATA GCG TGC GGG AAC GCT AGG GCC AAT AAA 543Gly Lys Val Ile Asp Ser Ile Ala Cys Gly Asn Ala Arg Ala Asn Lys
145 150 155ATC CGC CGT AAT TAC TTG ATG AAT AAC GCT TTT TTA GAA TAC CGC TAT 591Ile Arg Arg Asn Tyr Leu Met Asn Asn Ala Phe Leu Glu Tyr Arg Tyr
160 165 170AAA GAT ATT TTT TTA GCT AAG GGA GGG CGT TAT CAA TCC AAT GCT CCT 639Lys Asp Ile Phe Leu Ala Lys Gly Gly Arg Tyr Gln Ser Asn Ala Pro
175 180 185TATATG AGC GGT TAC ACG CAA GGC TTT GAA ATC AGC GCT AAA GTC AAG 687Tyr Met Ser Gly Tyr Thr Gln Gly Phe Glu Ile Ser Ala Lys Val Lys190 195 200 205GAT AAA AAT GAA GGA ATC CAC AAA TTA TGG TGG TTT AGC TCA TGG GGT 735Asp Lys Asn Glu Gly Ile His Lys Leu Trp Trp Phe Ser Ser Trp Gly
210 215 220AGG GCG TTC GCT TAT GGG GAG TGG ATT TAT GAT TTT TAT TCT CCA AGA 783Arg Ala Phe Ala Tyr Gly Glu Trp Ile Tyr Asp Phe Tyr Ser Pro Arg
225 230 235ACC GTG GTT AAA AAC GGG CGC ACT TTG AAT TAT GGT ATC CAT TTA GTG 831Thr Val Val Lys Asn Gly Arg Thr Leu Asn Tyr Gly Ile His Leu Val
240 245 250AAT TAT ACT TAT GAA AGA AAA GGG GTT AGC GTT AGC CCT TTT TTC CAA 879Asn Tyr Thr Tyr Glu Arg Lys Gly Val Ser Val Ser Pro Phe Phe Gln
255 260 265TTT TCG CCT GGG ACT TAT TAT AGC CCT GGG GTG GTT GTA GGC TAT GAT 927Phe Ser Pro Gly Thr Tyr Tyr Ser Pro Gly Val Val Val Gly Tyr Asp270 275 280 285AGT AAC CCT AAT TTT AAC GGC GTT GGC TTT AGA TCC GAA ACA AAA GCT 978Ser Asn Pro Asn Phe Asn Gly Val Gly Phe Arg Ser Glu Thr Lys Ala
290 295 300TAT ATT TTG CTC CCT GTC CAT GAC CCC TTA AGA AGG GAT ACT TAT CGT 1023Tyr Ile Leu Leu Pro Val His Asp Pro Leu Arg Arg Asp Thr Tyr Arg
305 310 315TAC GCT ATA AAG GCT GGC ACT GCC GGG CAA AGC TTG CTC ATT AGG CAA 1071Tyr Ala Ile Lys Ala Gly Thr Ala Gly Gln Ser Leu Leu Ile Arg Gln
320 325 330CGA TTT GAT TAC AAT GAA TTT AAT TTT GGG GGA GCG TTT TAT AAA GTA 1119Arg Phe Asp Tyr Asn Glu Phe Asn Phe Gly Gly Ala Phe Tyr Lys Val
335 340 345TGG AAA AAC GCA AAC GCT TAC ATC GGC ACG ACA GGA AAC CCT TTA GGC 1167Trp Lys Asn Ala Asn Ala Tyr Ile Gly Thr Thr Gly Asn Pro Leu Gly350 355 360 365ATT GAT TTT TGG ACC AAT AGC GTT TAT GAT ATA GGG CAA GCT TTA AGC 1215Ile Asp Phe Trp Thr Asn Ser Val Tyr Asp Ile Gly Gln Ala Leu Ser
370 375 380CAT GTG GTA ACC GCT GAT GCC GTC TCT GGT TGG GTT TTT GGT GGG GGC 1263His Val Val Thr Ala Asp Ala Val Ser Gly Trp Val Phe Gly Gly Gly
385 390 395GTG CAT AAA AAG TGG CTG TGG GGG ACT TTA TGG CGT TGG ACT AGC GGC 1311Val His Lys Lys Trp Leu Trp Gly Thr Leu Trp Arg Trp Thr Ser Gly
400 405 410ACT TTA GCC AAT GAA GCG AGT GCG GCT GTT AAT GTG GGC TAT AAG ATC 1359Thr Leu Ala Asn Glu Ala Ser Ala Ala Val Asn Val Gly Tyr Lys Ile
415 420 425AGT AAG AGT TTG ACA GCG AGC GTG AAA TTA GAA TAT TTG GGC GTG ATG 1407Ser Lys Ser Leu Thr Ala Ser Val Lys Leu Glu Tyr Leu Gly Val Met430 435 440 445ACG CAT GCA GGC TTT ACG GTA GGG AGT TAC AGG CCC ACG CCC GGC TCT 1455Thr His Ala Gly Phe Thr Val Gly Ser Tyr Arg Pro Thr Pro Gly Ser
450 455 460AAA GCG CTT TAT TCA GAC AGG AGT CAT TTG ATG ACA ACT CTT AGC GCT 1503Lys Ala Leu Tyr Ser Asp Arg Ser His Leu Met Thr Thr Leu Ser Ala
465 470 475AAA TTC TAACCAATCG CTTTAAGCTG TTTATTAAAG CGTTAAAAAT CCCTTAATAA AA 1561Lys PheA 1562
(2) Data of sequence 14:
(i) sequence characteristics:
(A) length: 479 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 14: met Lys Asn Ser Thr Pro Leu Lys Asn Gln Val Phe Cys Gly Leu Tyr 151015 Val Leu Ser Leu Ser Ala Ser Leu Gln Ala Phe Asp Tyr Lys Ile Glu
20 25 30Val Ser Ala Glu Ser Phe Ser Lys Val Gly Phe Asn Lys Lys Lys Ile
35 40 45Asp Ile Ala Arg Gly Ile Tyr Pro Thr Glu Thr Phe Val Thr Ala Val
50 55 60Gly Gln Gly Asn Ile Tyr Ala Asp Phe Leu Pro Lys Gly Leu Lys Asp65 70 75 80Gln Gly His Val Leu Glu Gly Lys Ile Gly Gly Thr Leu Gly Gly Val
85 90 95Ala Tyr Asp Ser Thr Lys Phe Asn Gln Gly Gly Ser Val Ile Tyr Asn
100 105 110Tyr Ile Gly Tyr Trp Asp Gly Tyr Leu Gly Gly Lys Arg Ala Leu Leu
115 120 125Asp Gly Thr Ser Ile His Glu Cys Ala Leu Gly Ser Asp Gly Lys Val
130 135 140Ile Asp Ser Ile Ala Cys Gly Asn Ala Arg Ala Asn Lys Ile Arg Arg145 150 155 160Asn Tyr Leu Met Asn Asn Ala Phe Leu Glu Tyr Arg Tyr Lys Asp Ile
165 170 175Phe Leu Ala Lys Gly Gly Arg Tyr Gln Ser Asn Ala Pro Tyr Met Ser
180 185 190Gly Tyr Thr Gln Gly Phe Glu Ile Ser Ala Lys Val Lys Asp Lys Asn
195 200 205Glu Gly Ile His Lys Leu Trp Trp Phe Ser Ser Trp Gly Arg Ala Phe
210 215 220Ala Tyr Gly Glu Trp Ile Tyr Asp Phe Tyr Ser Pro Arg Thr Val Val225 230 235 240Lys Asn Gly Arg Thr Leu Asn Tyr Gly Ile His Leu Val Asn Tyr Thr
245 250 255Tyr Glu Arg Lys Gly Val Ser Val Ser Pro Phe Phe Gln Phe Ser Pro
260 265 270Gly Thr Tyr Tyr Ser Pro Gly Val Val Val Gly Tyr Asp Ser Asn Pro
275 280 285Asn Phe Asn Gly Val Gly Phe Arg Ser Glu Thr Lys Ala Tyr Ile Leu
290 295 300Leu Pro Val His Asp Pro Leu Arg Arg Asp Thr Tyr Arg Tyr Ala Ile305 310 315 320Lys Ala Gly Thr Ala Gly Gln Ser Leu Leu Ile Arg Gln Arg Phe Asp
325 330 335Tyr Asn Glu Phe Asn Phe Gly Gly Ala Phe Tyr Lys Val Trp Lys Asn
340 345 350Ala Asn Ala Tyr Ile Gly Thr Thr Gly Asn Pro Leu Gly Ile Asp Phe
355 360 365Trp Thr Asn Ser Val Tyr Asp Ile Gly Gln Ala Leu Ser His Val Val
370 375 380Thr Ala Asp Ala Val Ser Gly Trp Val Phe Gly Gly Gly Val His Lys385 390 395 400Lys Trp Leu Trp Gly Thr Leu Trp Arg Trp Thr Ser Gly Thr Leu Ala
405410 415Asn Glu Ala Ser Ala Ala Val Asn Val Gly Tyr Lys Ile Ser Lys Ser
420 425 430Leu Thr Ala Ser Val Lys Leu Glu Tyr Leu Gly Val Met Thr His Ala
435 440 445Gly Phe Thr Val Gly Ser Tyr Arg Pro Thr Pro Gly Ser Lys Ala Leu
450 455 460Tyr Ser Asp Arg Ser His Leu Met Thr Thr Leu Ser Ala Lys Phe465 470 475
(2) Sequence 15 data: (i) sequence characteristics:
(A) length: 810bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 98...757
(D) Other information: (xi) Description of the sequence: sequence 15: CTAATATTTA TTTTAAACTT TGTTATTATT TAAGGTGTGA TTTGATTTTA GTCTGTATGG 60GGCAAGTGTG GGGCAGGATA ACATAAGGAA TTGGGTT ATG AAT AAA ACA ACG GTT 115
Met Asn Lys Thr Thr Val
1 5AAA ATA TTA ATG GGC ATG GCG TTA TTA TCA TCG CTT CAA GCC GCA GAG 163Lys Ile Leu Met Gly Met Ala Leu Leu Ser Ser Leu Gln Ala Ala Glu
10 15 20GCA GAG CTT GAT GAA AAA TCA AAA AAA CCT AAA TTT GCG GAC AGG AAT 211Ala Glu Leu Asp Glu Lys Ser Lys Lys Pro Lys Phe Ala Asp Arg Asn
25 30 35ACA TTT TAT TTA GGG GTT GGG TAT CAA CTT AGT GCG ATC AAC ACA TCT 259Thr Phe Tyr Leu Gly Val Gly Tyr Gln Leu Ser Ala Ile Asn Thr Ser
40 45 50TTT AGC ACC GAG TCT GTA GAT AAA TCG TAT TTT ATG ACC GGC AAT GGC 307Phe Ser Thr Glu Ser Val Asp Lys Ser Tyr Phe Met Thr Gly Asn Gly55 60 65 70TTT GGT GTG GTG TTA GGG GGG AAA TTT GTG GCT AAA ACG CAA GCT GTA 355Phe Gly Val Val Leu Gly Gly Lys Phe Val Ala Lys Thr Gln Ala Val
75 80 85GAG CAT GTG GGT TTC CGT TAC GGG TTG TTT TAT GAT CAG ACC TTT TCT 403Glu His Val Gly Phe Arg Tyr Gly Leu Phe Tyr Asp Gln Thr Phe Ser
90 95 100TCT CAC AAA TCC TAT ATT TCT ACC TAT GGT TTA GAA TTT AGC GGT TTG 451Ser His Lys Ser Tyr Ile Ser Thr Tyr Gly Leu Glu Phe Ser Gly Leu
105 110 115TGG GAC GCT TTC AAT TCG CCA AAG ATG TTT TTA GGG TTA GAG TTT GGC 499Trp Asp Ala Phe Asn Ser Pro Lys Met Phe Leu Gly Leu Glu Phe Gly
120 125 130TTA GGC ATC GCT GGG GCG ACT TAT ATG CCA GGA GGG GCT ATG CAT GGG 547Leu Gly Ile Ala Gly Ala Thr Tyr Met Pro Gly Gly Ala Met His Gly135 140 145 150ATT ATC GCT CAA AAT TTA GGC AAA GAA AAT TCG CTT TTC CAA TTG CTT 595Ile Ile Ala Gln Asn Leu Gly Lys Glu Asn Ser Leu Phe Gln Leu Leu
155 160 165GTG AAA GTG GGT TTT CGT TTT GGC TTT TTG CAC AAT GAA ATC ACT TTC 643Val Lys Val Gly Phe Arg Phe Gly Phe Leu His Asn Glu Ile Thr Phe
170 175 180GGG TTG AAA TTC CCT GTC ATT CCT AAC AAA AGA ACG GAA ATC ATT GAT 691Gly Leu Lys Phe Pro Val Ile Pro Asn Lys Arg Thr Glu Ile Ile Asp
185 190195GGC TTG AGC ACG ACT ACT TTA TGG CAC CGC TTA CCG GTA GCT TAT TTC 739Gly Leu Ser Thr Thr Thr Leu Trp His Arg Leu Pro Val Ala Tyr Phe
200 205 210AAT TAT ATC TAT AAT TTT TAGATATGGT TATTTAGAGG TTTTAGATTT GACAAAAT 795Asn Tyr Ile Tyr Asn Phe215 220CAATCAACTC TCGTG 810
(2) Sequence 16 data:
(i) sequence characteristics:
(A) length: 220 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 16: met Asn Lys Thr Thr Val Lys Ile Leu Met Gly Met Ala Leu Leu Ser 151015 Ser Leu Gln Ala Ala Glu Ala Glu Leu Asp Glu Lys Ser Lys Lys Pro
20 25 30Lys Phe Ala Asp Arg Asn Thr Phe Tyr Leu Gly Val Gly Tyr Gln Leu
35 40 45Ser Ala Ile Asn Thr Ser Phe Ser Thr Glu Ser Val Asp Lys Ser Tyr
50 55 60Phe Met Thr Gly Asn Gly Phe Gly Val Val Leu Gly Gly Lys Phe Val65 70 75 80Ala Lys Thr Gln Ala Val Glu His Val Gly Phe Arg Tyr Gly Leu Phe
85 90 95Tyr Asp Gln Thr Phe Ser Ser His Lys Ser Tyr Ile Ser Thr Tyr Gly
100 105 110Leu Glu Phe Ser Gly Leu Trp Asp Ala Phe Asn Ser Pro Lys Met Phe
115 120 125Leu Gly Leu Glu Phe Gly Leu Gly Ile Ala Gly Ala Thr Tyr Met Pro
130 135 140Gly Gly Ala Met His Gly Ile Ile Ala Gln Asn Leu Gly Lys Glu Asn145 150 155 160Ser Leu Phe Gln Leu Leu Val Lys Val Gly Phe Arg Phe Gly Phe Leu
165 170 175His Asn Glu Ile Thr Phe Gly Leu Lys Phe Pro Val Ile Pro Asn Lys
180 185 190Arg Thr Glu Ile Ile Asp Gly Leu Ser Thr Thr Thr Leu Trp His Arg
195 200 205Leu Pro Val Ala Tyr Phe Asn Tyr Ile Tyr Asn Phe
210 215 220
(2) Sequence 17 data: (i) sequence characteristics:
(A) length: 1516bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...1463
(D) Other information: (xi) Description of the sequence: sequence 17: TTTATCTTTA AAAGTATTTG CATTTATCAA TCTCATTTTA GGAGGCATGC ATG AAA 56
Met Lys
1AAG GCA AGT CAG GTT TTA TTC TTT GGG GCA TTT TTA AGC TCT TCT TTG 104Lys Ala Ser Gln Val Leu Phe Phe Gly Ala Phe Leu Ser Ser Ser Leu
5 10 15CAA GGT TTT GAA GCT AAG CTC AAC GGC TTT GTG GAT CAA TCC AGC ACT 152Gln Gly Phe Glu Ala Lys Leu Asn GlyPhe Val Asp Gln Ser Ser Thr
20 25 30ATC GGT TTT AAC CAG CAT AAA ATC AAT AAA GAA AGA GGT ATC TAC CCT 200Ile Gly Phe Asn Gln His Lys Ile Asn Lys Glu Arg Gly Ile Tyr Pro35 40 45 50ATG CAG CAA TTC GCA ACG ATT GCG GGC TAT TTA GGG CTT GGT TTT AGC 248Met Gln Gln Phe Ala Thr Ile Ala Gly Tyr Leu Gly Leu Gly Phe Ser
55 60 65CTG TTA CCC AAA AAG GTT TCA GAC CAT GTT CTA AAA GGC AAA ATA GGA 296Leu Leu Pro Lys Lys Val Ser Asp His Val Leu Lys Gly Lys Ile Gly
70 75 80GGC ATG GTG GGA TCT ATT TTC TAT GAT GGC ACG AAG AAG TTT GAA GAC 344Gly Met Val Gly Ser Ile Phe Tyr Asp Gly Thr Lys Lys Phe Glu Asp
85 90 95AGC TCT GTA GCT TAC AAC CTC TTT GGT TAT TAT GAT GGG TTC ATG GGG 392Ser Ser Val Ala Tyr Asn Leu Phe Gly Tyr Tyr Asp Gly Phe Met Gly
100 105 110GGT TAT ACA AAC ATC TTA CAA AGC GAT GAT TTA GCG ACA CAA AAC ATG 440Gly Tyr Thr Asn Ile Leu Gln Ser Asp Asp Leu Ala Thr Gln Asn Met115 120 125 130AAA TAC AAT AAA AAT GTC CGC AAC TAT GTC TTT AGC GAC GCG TAT TTA 488Lys Tyr Asn Lys Asn Val Arg Asn Tyr Val Phe Ser Asp Ala Tyr Leu
135 140 145GAA TAC GCT TAT AAG AAT TAT TTT GAA ATA AAA GCC GGG CGC TAT TTA 536Glu Tyr Ala Tyr Lys Asn Tyr Phe Glu Ile Lys Ala Gly Arg Tyr Leu
150 155 160TCC ACT ATG CCT TAT AAA AGC GGT CAA ACG CAA GGC TTT CAA ATT TCT 584Ser Thr Met Pro Tyr Lys Ser Gly Gln Thr Gln Gly Phe Gln Ile Ser
165 170 175GGG CAA TAC AAG AAA GCG CGC TTG ACT TGG TTT AGC TCT TTT GGG AGG 632Gly Gln Tyr Lys Lys Ala Arg Leu Thr Trp Phe Ser Ser Phe Gly Arg
180 185 190GCG TTC GCT TAC GGC TCG TTT TTG ATG GAT TGG TTT GCC GCT AGG ACC 680Ala Phe Ala Tyr Gly Ser Phe Leu Met Asp Trp Phe Ala Ala Arg Thr195 200 205 210ACT TAT AGC GGA GGT TTT ACC AAA AAC GAT AAG GGA GGT TAT GAT AGC 728Thr Tyr Ser Gly Gly Phe Thr Lys Asn Asp Lys Gly Gly Tyr Asp Ser
215 220 225CAT GGG CGA AAG GTG CTT TAT GGC ACG CAT GCG GTG CAA CTC ACC TAT 776His Gly Arg Lys Val Leu Tyr Gly Thr His Ala Val Gln Leu Thr Tyr
230 235 240AAA CCT CAT CGT TTC CTC ATA GAA GGC TTT TAT TAC CTT TCG CCT CAA 824Lys Pro His Arg Phe Leu Ile Glu Gly Phe Tyr Tyr Leu Ser Pro Gln
245 250 255ATC TTT AAC GCT CCG GGC GTT AAG ATT GGT TGG GAT TCT AAC CCT AAT 872Ile Phe Asn Ala Pro Gly Val Lys Ile Gly Trp Asp Ser Asn Pro Asn
260 265 270TTT AGC GGC ACA GGC TTT CGC TCT GAT ACA GCT ATC ATA GGG TTT TTC 920Phe Ser Gly Thr Gly Phe Arg Ser Asp Thr Ala Ile Ile Gly Phe Phe275 280 285 290CCC ATT TAC TAC CCT TGG ATG ATC GTT AAA TCC AAT GGA AGC CCG GTC 968Pro Ile Tyr Tyr Pro Trp Met Ile Val Lys Ser Asn Gly Ser Pro Val
295 300 305TAT AAA TAC GAC ACG CCT GCC ACT CAA AAT GGG CAA AAC CTC ATT ATC 1016Tyr Lys Tyr Asp Thr Pro Ala Thr Gln Asn Gly Gln Asn Leu Ile Ile
310 315 320CTC CAA CGC TTT GAC ATC AAC AAT TAC AAT GTT TCC ATC GCT TTT TAT 1064Leu Gln Arg Phe Asp Ile Asn Asn Tyr Asn Val Ser Ile Ala Phe Tyr
325 330 335AAA GTC TTT CAA AAC GCT AAT GGT TGG ATA GGC AAC ATG GGG AAT CCA 1112Lys Val Phe Gln Asn Ala Asn Gly Trp Ile Gly Asn Met Gly Asn Pro
340 345 350AGC GGT GTG ATC ATG GGG AGT AAC AGC GTC TAT GCG GGT TTT ACA GGC 1160Ser Gly Val Ile Met Gly Ser Asn Ser Val Tyr Ala Gly Phe Thr Gly355 360 365 370ACA GCC CTT AAA AGA GAT GCC GCT ACC ATT TTC CTT TCT TGT GGC GGC 1208Thr Ala Leu Lys Arg Asp Ala Ala Thr Ile Phe Leu Ser Cys Gly Gly
375 380 385ACT CAT TTT GCC AAA AAA TTC ACA TGG AAA TTC GCC ACG CAA TAC TCC 1256Thr His Phe Ala Lys Lys Phe Thr Trp Lys Phe Ala Thr Gln Tyr Ser
390 395 400AAT TCA GTG GTT TCT TGG GAA GCG AGA GCG ATG ATC TCT TTA GGT TAT 1304Asn Ser Val Val Ser Trp Glu Ala Arg Ala Met Ile Ser Leu Gly Tyr
405 410 415AAA TTC ACT GAA TAC TTG AGC GGT AGC GTG GAT CTT GCA TAT TAT GGC 1352Lys Phe Thr Glu Tyr Leu Ser Gly Ser Val Asp Leu Ala Tyr Tyr Gly
420 425 430GTG TAT ACT AAC AAA GGA TTT AAA CCG GGT GAA AAC GGG CCT GTG CCT 1400Val Tyr Thr Asn Lys Gly Phe Lys Pro Gly Glu Asn Gly Pro Val Pro435 440 445 450AAA GAC TTC CCC GCC CTT TAT TCT GAC AGG AGC GCG TTA TAC ACG GCT 1448Lys Asp Phe Pro Ala Leu Tyr Ser Asp Arg Ser Ala Leu Tyr Thr Ala
455 460 465CTA GTA GCA TCT TTT TGATGCTACC CTATGATTAT GGTGGGCGTC TTTTGATGCT G 1504Leu Val Ala Ser Phe
470TTTCTCTAGT CT 1516
(2) Sequence 18 data: (i) sequence characteristics:
(A) length: 471 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 18: met Lys Lys Ala Ser Gln Val Leu Phe Phe Gly Ala Phe Leu Ser Ser 151015 Ser Leu Gln Gly Phe Glu Ala Lys Leu Asn Gly Phe Val Asp Gln Ser
20 25 30Ser Thr Ile Gly Phe Asn Gln His Lys Ile Asn Lys Glu Arg Gly Ile
35 40 45Tyr Pro Met Gln Gln Phe Ala Thr Ile Ala Gly Tyr Leu Gly Leu Gly
50 55 60Phe Ser Leu Leu Pro Lys Lys Val Ser Asp His Val Leu Lys Gly Lys65 70 75 80Ile Gly Gly Met Val Gly Ser Ile Phe Tyr Asp Gly Thr Lys Lys Phe
85 90 95Glu Asp Ser Ser Val Ala Tyr Asn Leu Phe Gly Tyr Tyr Asp Gly Phe
100 105 110Met Gly Gly Tyr Thr Asn Ile Leu Gln Ser Asp Asp Leu Ala Thr Gln
115 120 125Asn Met Lys Tyr Asn Lys Asn Val Arg Asn Tyr Val Phe Ser Asp Ala
130 135 140Tyr Leu Glu Tyr Ala Tyr Lys Asn Tyr Phe Glu Ile Lys Ala Gly Arg145 150 155 160Tyr Leu Ser Thr Met Pro Tyr Lys Ser Gly Gln Thr Gln Gly Phe Gln
165 170 175Ile Ser Gly Gln Tyr Lys Lys Ala Arg Leu Thr Trp Phe Ser Ser Phe
180 185190Gly Arg Ala Phe Ala Tyr Gly Ser Phe Leu Met Asp Trp Phe Ala Ala
195 200 205Arg Thr Thr Tyr Ser Gly Gly Phe Thr Lys Asn Asp Lys Gly Gly Tyr
210 215 220Asp Ser His Gly Arg Lys Val Leu Tyr Gly Thr His Ala Val Gln Leu225 230 235 240Thr Tyr Lys Pro His Arg Phe Leu Ile Glu Gly Phe Tyr Tyr Leu Ser
245 250 255Pro Gln Ile Phe Asn Ala Pro Gly Val Lys Ile Gly Trp Asp Ser Asn
260 265 270Pro Asn Phe Ser Gly Thr Gly Phe Arg Ser Asp Thr Ala Ile Ile Gly
275 280 285Phe Phe Pro Ile Tyr Tyr Pro Trp Met Ile Val Lys Ser Asn Gly Ser
290 295 300Pro Val Tyr Lys Tyr Asp Thr Pro Ala Thr Gln Asn Gly Gln Asn Leu305 310 315 320Ile Ile Leu Gln Arg Phe Asp Ile Asn Asn Tyr Asn Val Ser Ile Ala
325 330 335Phe Tyr Lys Val Phe Gln Asn Ala Asn Gly Trp Ile Gly Asn Met Gly
340 345 350Asn Pro Ser Gly Val Ile Met Gly Ser Asn Ser Val Tyr Ala Gly Phe
355 360 365Thr Gly Thr Ala Leu Lys Arg Asp Ala Ala Thr Ile Phe Leu Ser Cys
370 375 380Gly Gly Thr His Phe Ala Lys Lys Phe Thr Trp Lys Phe Ala Thr Gln385 390 395 400Tyr Ser Asn Ser Val Val Ser Trp Glu Ala Arg Ala Met Ile Ser Leu
405 410 415Gly Tyr Lys Phe Thr Glu Tyr Leu Ser Gly Ser Val Asp Leu Ala Tyr
420 425 430Tyr Gly Val Tyr Thr Asn Lys Gly Phe Lys Pro Gly Glu Asn Gly Pro
435 440 445Val Pro Lys Asp Phe Pro Ala Leu Tyr Ser Asp Arg Ser Ala Leu Tyr
450 455 460Thr Ala Leu Val Ala Ser Phe465 470
(2) Data for sequence 19: (i) sequence characteristics:
(A) length: 377bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 87...323
(D) Other information: (xi) Description of the sequence: sequence 19: AAATTTATGT TATAATTAAA CGCATTGTAA ATAAATTCTC ATTTTGATAC ATTTTTACAA 60TAAAACATTA CTTTAAGGAA CATCTT ATG AAA AAA ACG AAA AAA ACG ATT CTG 113
Met Lys Lys Thr Lys Lys Thr Ile Leu
1 5CTT TCT CTA ACT CTC GCG GCG TCA TTG CTC CAT GCT GAA GAC AAC GGC 161Leu Ser Leu Thr Leu Ala Ala Ser Leu Leu His Ala Glu Asp Asn Gly10 15 20 25GTT TTT TTA AGC GTG GGT TAT CAA ATC GGT GAA GCG GTT CAA AAA GTG 209Val Phe Leu Ser Val Gly Tyr Gln Ile Gly Glu Ala Val Gln Lys Val
30 35 40AAA AAC GCC GAC AAG GTG CAA AAA CTT TCA GAC ACT TAT GAA CAA TTA 257Lys Asn Ala Asp Lys Val Gln Lys Leu Ser Asp Thr Tyr Glu Gln Leu
45 50 55AGCCGG CTT TTA ACC AAC GAT AAT GGC ACA AAC TCA AAG ACA AGC GCG 305Ser Arg Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala
60 65 70CAA NAT CAA CCA AGC GGT TAATAATTTG AACGAACGCG CAAAAACTTT AGCCGGTG 361Gln Xaa Gln Pro Ser Gly
75GGACAACCAA TTCCCC 377
(2) Sequence 20 data:
(i) sequence characteristics:
(A) length: 79 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 20: met Lys Lys Thr Lys Lys Thr Ile Leu Leu Ser Leu Thr Leu Ala Ala 151015 Ser Leu Leu His Ala Glu Asp Asn Gly Val Phe Leu Ser Val Gly Tyr
20 25 30Gln Ile Gly Glu Ala Val Gln Lys Val Lys Asn Ala Asp Lys Val Gln
35 40 45Lys Leu Ser Asp Thr Tyr Glu Gln Leu Ser Arg Leu Leu Thr Asn Asp
50 55 60Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Xaa Gln Pro Ser Gly65 70 75
(2) Sequence 21 data:
(i) sequence characteristics:
(A) length: 2169bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 60...2039
(D) Other information:
(xi) Description of the sequence: sequence 21: CCCTATCATA GGGCGTGGCA TGAAGAAAAA AGCAAAAGTC TTTTGGTATT GTTTTAATC 59ATG ATT TAT TGG TTG TAT TTG GCG GTC TTT TTT TTG TTG AGC GCA TTA 107Met Ile Tyr Trp Leu Tyr Leu Ala Val Phe Phe Leu Leu Ser Ala Leu 151015 GAC GCT AAA GAA ATC GCT ATG CAA CGA TTT GAC AAA CAA AAC CAT AAG 155Asp Ala Lys Glu Ile Ala Met Gln Arg Phe Asp Lys Gln Asn His Lys
20 25 30ATT TTT GAA ATC CTT GCG GAT AAA GTG AGC GCT AAA GAC AAT GTG ATA 203Ile Phe Glu Ile Leu Ala Asp Lys Val Ser Ala Lys Asp Asn Val Ile
35 40 45ACC GCA TCA GGG AAT GCG ATC TTA TTG AAT TAT GAT GTG TAT ATT CTA 251Thr Ala Ser Gly Asn Ala Ile Leu Leu Asn Tyr Asp Val Tyr Ile Leu
50 55 60GCG GAC AAG GTG CGT TAT GAC ACT AAA ACC AAA GAA GCG TTA TTA GAG 299Ala Asp Lys Val Arg Tyr Asp Thr Lys Thr Lys Glu Ala Leu Leu Glu 65 70 75 80GGG AAT ATC AAG GTT TAT AGG GGC GAG GGT TTG CTC GTT AAA ACC GAT 347Gly Asn Ile Lys Val Tyr Arg Gly Glu Gly Leu Leu Val Lys Thr Asp
85 90 95TAC GTG AAA TTG AGT TTG AAT GAA AAA TAT GAA ATC ATT TTC CCC TTT 395Tyr Val Lys Leu Ser Leu Asn Glu Lys Tyr Glu Ile Ile Phe Pro Phe
100 105 110TAT GTC CAA GAC AGC GTG AGC GGG ATT TGG GTG AGC GCG GAT ATT GCC 443Tyr Val Gln Asp Ser Val Ser Gly Ile Trp Val Ser Ala Asp Ile Ala
115 120 125AGC GGA AAG GAT CAA AAA TAT AAG GTT AAA AAC ATG AGC ACT TCA GGG 491Ser Gly Lys Asp Gln Lys Tyr Lys Val Lys Asn Met Ser Thr Ser Gly
130 135 140TGC AGC ATT GAT AAC CCC ATT TGG CAT GTC AAT GCG ACT TCA GGC TCA 539Cys Ser Ile Asp Asn Pro Ile Trp His Val Asn Ala Thr Ser Gly Ser145 150 155 160TTC AAC ATG CAA AAA TCG CAT TTG TCT ATG TGG AAT CCT AAG ATC TAT 587Phe Asn Met Gln Lys Ser His Leu Ser Met Trp Asn Pro Lys Ile Tyr
165 170 175GTC GGT GAT ATT CCT GTA TTG TAT TTG CCC TAT ATT TTC ATG TCC ACG 635Val Gly Asp Ile Pro Val Leu Tyr Leu Pro Tyr Ile Phe Met Ser Thr
180 185 190AGC AAT AAA AGA ACT ACT GGG TTT TTA TAC CCT GAG TTT GGC ACT TCC 683Ser Asn Lys Arg Thr Thr Gly Phe Leu Tyr Pro Glu Phe Gly Thr Ser
195 200 205AAC TTA GAC GGC TTT ATT TAT TTG CAA CCC TTT TAT TTA GCC CCC AAA 731Asn Leu Asp Gly Phe Ile Tyr Leu Gln Pro Phe Tyr Leu Ala Pro Lys
210 215 220AAC TCA TGG GAT ATG ACC TTT ACC CCA CAA ATC CGC TAT AAA AGG GGT 779Asn Ser Trp Asp Met Thr Phe Thr Pro Gln Ile Arg Tyr Lys Arg Gly225 230 235 240TTT GGC TTG AAT TTT GAA GCG CGC TAC ATT AAC TCT AAA AAC GAC AGG 827Phe Gly Leu Asn Phe Glu Ala Arg Tyr Ile Asn Ser Lys Asn Asp Arg
245 250 255TTT TTA TTC AAC GCG CGC TAT TTT AGG AAT TAC ACC CAA TAT GTC AAA 875Phe Leu Phe Asn Ala Arg Tyr Phe Arg Asn Tyr Thr Gln Tyr Val Lys
260 265 270CGC TAC GAT TTG AGG AAT CAA AAT ATC TAC GGG TTT GAA TTT TTA AGC 923Arg Tyr Asp Leu Arg Asn Gln Asn Ile TyrGly Phe Glu Phe Leu Ser
275 280 285TCT AGC AGG GAC ACT TTA CAA AAA TAC TTC CAC CTT AAG TCT AAT ATT 971Ser Ser Arg Asp Thr Leu Gln Lys Tyr Phe His Leu Lys Ser Asn Ile
290 295 300GAC AAC GGG CAT TAC ATT GAC TTT TTA TAC ATG AAC GAT TTG GAC TAT 1019Asp Asn Gly His Tyr Ile Asp Phe Leu Tyr Met Asn Asp Leu Asp Tyr305 310 315 320GTG CGT TTT GAA AAG GTT AAT AAG CGT ATC ACA GAC GCC ACG CAC ATG 1067Val Arg Phe Glu Lys Val Asn Lys Arg Ile Thr Asp Ala Thr His Met
325 330 335TCT AGG GCG AAT TAC TAT TTG CAA ACA GAA AAC AAT TAT TAC GGC TTG 1115Ser Arg Ala Asn Tyr Tyr Leu Gln Thr Glu Asn Asn Tyr Tyr Gly Leu
340 345 350AAT ATC AAG TAT TTT TTA AAC CTG AAT AAA ATC AAC AAT AAC CGC ACT 1163Asn Ile Lys Tyr Phe Leu Asn Leu Asn Lys Ile Asn Asn Asn Arg Thr
355 360 365TTC CAA TCT GTC CCT AAT TTG CAA TAC CAT AAA TAT TTA AAT TCT TTG 1211Phe Gln Ser Val Pro Asn Leu Gln Tyr His Lys Tyr Leu Asn Ser Leu
370 375 380TAT TTT AGA AAT TTG TTG TAT TCG GTG GAT TAT CAG TTT AGA AAC ACC 1259Tyr Phe Arg Asn Leu Leu Tyr Ser Val Asp Tyr Gln Phe Arg Asn Thr385 390 395 400GCA AGA GAG ATT GGT TAT GGC TAT GTG CAA AAC GCT TTG AAT GTG CCG 1307Ala Arg Glu Ile Gly Tyr Gly Tyr Val Gln Asn Ala Leu Asn Val Pro
405 410 415GTG GGC TTG CAA TTT TCT TTG TTT AAA AAG TAT TTG TCT TTA GGG CTT 1355Val Gly Leu Gln Phe Ser Leu Phe Lys Lys Tyr Leu Ser Leu Gly Leu
420 425430TGG AAT GAT CTC CAA CTA TCT AAT GTG GCT TTA ATG CAA TCT AAA AAT 1403Trp Asn Asp Leu Gln Leu Ser Asn Val Ala Leu Met Gln Ser Lys Asn
435 440 445TCC TTC GTG CCT ACG ATC CCT AAT GAA TCA AGG GAA TTT GGG AAT TTT 1451Ser Phe Val Pro Thr Ile Pro Asn Glu Ser Arg Glu Phe Gly Asn Phe
450 455 460GTG TCT TCA AAT TTT TCC ATG TAT GTC AAT ACG GAT TTG GCT AGA GAA 1499Val Ser Ser Asn Phe Ser Met Tyr Val Asn Thr Asp Leu Ala Arg Glu465 470 475 480TAC AAC AAG CTT TTC CAC ACG ATC CAA CTA GAA GCG ATT TTC AAC ATC 1547Tyr Asn Lys Leu Phe His Thr Ile Gln Leu Glu Ala Ile Phe Asn Ile
485 490 495CCT TAT TAC ACC TTT AAA AAC GGC TTA TTT TCT CAA AAC ATG TAT GCT 1595Pro Tyr Tyr Thr Phe Lys Asn Gly Leu Phe Ser Gln Asn Met Tyr Ala
500 505 510TTA AGC GCG CAA GCC TTA AAC AGC TAC ACT TCG CCT TTA TTG AGA GAT 1643Leu Ser Ala Gln Ala Leu Asn Ser Tyr Thr Ser Pro Leu Leu Arg Asp
515 520 525TAT GAT TAT CAA GGG CGT TTG TAT GAC TCG GTG TGG AAT CCT AGC AGT 1691Tyr Asp Tyr Gln Gly Arg Leu Tyr Asp Ser Val Trp Asn Pro Ser Ser
530 535 540ATT TTA CCT AGC AAT GCG AGC AAC AAG ACG GTG GAT TTA ACC CTA ACG 1739Ile Leu Pro Ser Asn Ala Ser Asn Lys Thr Val Asp Leu Thr Leu Thr545 550 555 560CAA TAC CTT TAT GGC TTA GGG GGG CAA GAG TTA TTG TAT TTT AAA ATA 1787Gln Tyr Leu Tyr Gly Leu Gly Gly Gln Glu Leu Leu Tyr Phe Lys Ile555 570 575TCG CAA CTC ATC AAT CTT GAC GAT AAA GTT TCG CCC TTT AGA ATG CCA 1835Ser Gln Leu Ile Asn Leu Asp Asp Lys Val Ser Pro Phe Arg Met Pro
580 585 590CTA GAG AGC AAG ATC GGG TTT TCG CCC TTA ACG GGA TTG AAC ATC TTT 1883Leu Glu Ser Lys Ile Gly Phe Ser Pro Leu Thr Gly Leu Asn Ile Phe
595 600 605GGG AAT GTC TTT TAT TCG TTT TAT CAA AAC CGC TTA GAA GAA ATC TCT 1931Gly Asn Val Phe Tyr Ser Phe Tyr Gln Asn Arg Leu Glu Glu Ile Ser
610 615 620GTG AAC GCC AAT TAC CAA CGC AAG TTT TTA AGC TTT AAC CTC TCT TAT 1979Val Asn Ala Asn Tyr Gln Arg Lys Phe Leu Ser Phe Asn Leu Ser Tyr625 630 635 640TTT TTA AAA AAC AAT TTT AGC AGT GGG ATT AAT AGC ATT GTA GAA AAT 2027Phe Leu Lys Asn Asn Phe Ser Ser Gly Ile Asn Ser Ile Val Glu Asn
645 650 655CTG CGG ATT ATT TAAAGGCGGG TTTTAGCAAC GACTTTGGCT ATTTTTCCAT GAGCGC 2085Leu Arg Ile Ile
660GGATGTGGGT TATGATATTA GAAACAATGT GGTTTTAAAT TGGAATGTGG GGATTTATAA 2145AAAAATCCGT TGTTTTGGGA TTGG 2169
(2) Sequence 22 data: (i) sequence characteristics:
(A) length: 660 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 22: met Ile Tyr Trp Leu Tyr Leu Ala Val Phe Phe Leu Leu Ser Ala Leu 151015 Asp Ala Lys Glu Ile Ala Met Gln Arg Phe Asp Lys Gln Asn His Lys
20 25 30Ile Phe Glu Ile Leu Ala Asp Lys Val Ser Ala Lys Asp Asn Val Ile
35 40 45Thr Ala Ser Gly Asn Ala Ile Leu Leu Asn Tyr Asp Val Tyr Ile Leu
50 55 60Ala Asp Lys Val Arg Tyr Asp Thr Lys Thr Lys Glu Ala Leu Leu Glu65 70 75 80Gly Asn Ile Lys Val Tyr Arg Gly Glu Gly Leu Leu Val Lys Thr Asp
85 90 95Tyr Val Lys Leu Ser Leu Asn Glu Lys Tyr Glu Ile Ile Phe Pro Phe
100 105 110Tyr Val Gln Asp Ser Val Ser Gly Ile Trp Val Ser Ala Asp Ile Ala
115 120 125Ser Gly Lys Asp Gln Lys Tyr Lys Val Lys Asn Met Ser Thr Ser Gly
130 135 140Cys Ser Ile Asp Asn Pro Ile Trp His Val Asn Ala Thr Ser Gly Ser145 150 155 160Phe Asn Met Gln Lys Ser His Leu Ser Met Trp Asn Pro Lys Ile Tyr
165 170 175Val Gly Asp Ile Pro Val Leu Tyr Leu Pro Tyr Ile Phe Met Ser Thr
180 185 190Ser Asn Lys Arg Thr Thr Gly Phe Leu Tyr Pro Glu Phe Gly Thr Ser
195 200 205Asn Leu Asp Gly Phe Ile Tyr Leu Gln Pro Phe Tyr Leu Ala Pro Lys
210 215 220Asn Ser Trp Asp Met Thr Phe Thr Pro Gln Ile Arg Tyr Lys Arg Gly225 230 235 240Phe Gly Leu Asn Phe Glu Ala Arg Tyr Ile Asn Ser Lys Asn Asp Arg
245 250 255Phe Leu Phe Asn Ala Arg Tyr Phe Arg Asn Tyr Thr Gln Tyr Val Lys
260 265 270Arg Tyr Asp Leu Arg Asn Gln Asn Ile Tyr Gly Phe Glu Phe Leu Ser
275 280 285Ser Ser Arg Asp Thr Leu Gln Lys Tyr Phe His Leu Lys Ser Asn Ile
290 295 300Asp Asn Gly His Tyr Ile Asp Phe Leu Tyr Met Asn Asp Leu Asp Tyr305 310 315 320Val Arg Phe Glu Lys Val Asn Lys Arg Ile Thr Asp Ala Thr His Met
325 330 335Ser Arg Ala Asn Tyr Tyr Leu Gln Thr Glu Asn Asn Tyr Tyr Gly Leu
340 345 350Asn Ile Lys Tyr Phe Leu Asn Leu Asn Lys Ile Asn Asn Asn Arg Thr
355 360 365Phe Gln Ser Val Pro Asn Leu Gln Tyr His Lys Tyr Leu Asn Ser Leu
370 375 380Tyr Phe Arg Asn Leu Leu Tyr Ser Val Asp Tyr Gln Phe Arg Asn Thr385 390 395 400Ala Arg Glu Ile Gly Tyr Gly Tyr Val Gln Asn Ala Leu Asn Val Pro
405 410 415Val Gly Leu Gln Phe Ser Leu Phe Lys Lys Tyr Leu Ser Leu Gly Leu
420 425 430Trp Asn Asp Leu Gln Leu Ser Asn Val Ala Leu Met Gln Ser Lys Asn
435 440 445Ser Phe Val Pro Thr Ile Pro Asn Glu Ser Arg Glu Phe Gly Asn Phe
450 455 460Val Ser Ser Asn Phe Ser Met Tyr Val Asn Thr Asp Leu Ala Arg Glu465 470 475 480Tyr Asn Lys Leu Phe His Thr Ile Gln Leu Glu Ala Ile Phe Asn Ile
485 490 495Pro Tyr Tyr Thr Phe Lys Asn Gly Leu Phe Ser Gln Asn Met Tyr Ala
500 505510Leu Ser Ala Gln Ala Leu Asn Ser Tyr Thr Ser Pro Leu Leu Arg Asp
515 520 525Tyr Asp Tyr Gln Gly Arg Leu Tyr Asp Ser Val Trp Asn Pro Ser Ser
530 535 540Ile Leu Pro Ser Asn Ala Ser Asn Lys Thr Val Asp Leu Thr Leu Thr545 550 555 560Gln Tyr Leu Tyr Gly Leu Gly Gly Gln Glu Leu Leu Tyr Phe Lys Ile
565 570 575Ser Gln Leu Ile Asn Leu Asp Asp Lys Val Ser Pro Phe Arg Met Pro
580 585 590Leu Glu Ser Lys Ile Gly Phe Ser Pro Leu Thr Gly Leu Asn Ile Phe
595 600 605Gly Asn Val Phe Tyr Ser Phe Tyr Gln Asn Arg Leu Glu Glu Ile Ser
610 615 620Val Asn Ala Asn Tyr Gln Arg Lys Phe Leu Ser Phe Asn Leu Ser Tyr625 630 635 640Phe Leu Lys Asn Asn Phe Ser Ser Gly Ile Asn Ser Ile Val Glu Asn
645 650 655Leu Arg Ile Ile
660
(2) Sequence 23 data: (i) sequence characteristics:
(A) length: 454bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...401
(D) Other information: (xi) Description of the sequence: sequence 23: TCAAGGTGTG CCAAACATGC CTTGAAACTC AATTTTTGAA TCTCAATTTT ATG AAA 56
Met Lys
1GGA TTT GTT ATG AGT GGA TTA AAA GCA TTT AGT TGT GTA GTG GTT TTA 104Gly Phe Val Met Ser Gly Leu Lys Ala Phe Ser Cys Val Val Val Leu
5 10 15TGC GGT GCA ATG GCT AAT ACG GCT ATA GCT GGT CCT AAA ATA GAA GCA 152Cys Gly Ala Met Ala Asn Thr Ala Ile Ala Gly Pro Lys Ile Glu Ala
20 25 30AGG GGT GAG TTT GGC AGA TTT TGG GGG GGA GCT GTT GGT GGT GCA ATT 200Arg Gly Glu Phe Gly Arg Phe Trp Gly Gly Ala Val Gly Gly Ala Ile35 40 45 50GGG GGT GGT GTT GGT GGT GCA GTG GGG GGA GCT GTT GGT GGT CCT GCG 248Gly Gly Gly Val Gly Gly Ala Val Gly Gly Ala Val Gly Gly Pro Ala
55 60 65GGT GGT TGG GCT GGC AGA TTA GTT GGT GGT TCT GTG GGG AGA GAG TTT 296Gly Gly Trp Ala Gly Arg Leu Val Gly Gly Ser Val Gly Arg Glu Phe
70 75 80GGT CGG GAA ATA GGC GAT AGG GTA GAA GAT TAC ATC CGT GGC GTT GAT 344 Gly Arg Glu Ile Gly Asp Arg Val Glu Asp Tyr Ile Arg Gly Val Asp
85 90 95AGA GAG CCA CAA GCC CCA AGA GAA CCC ACC TAT GAT CGT CAT TTC GTG 392Arg Glu Pro Gln Ala Pro Arg Glu Pro Thr Tyr Asp Arg His Phe Val
100 105 110TAT GAC AGG TAGCTTTGGG CGAGAAAGGA GAGAGCATGA ATGTCAAAAA TCGTTTGAG 450Tyr Asp Arg115CGAT 454
(2) Sequence 24 data:
(i) sequence characteristics:
(A) length: 117 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 24: met Lys Gly Phe Val Met Ser Gly Leu Lys Ala Phe Ser Cys Val Val 151015 Val Leu Cys Gly Ala Met Ala Asn Thr Ala Ile Ala Gly Pro Lys Ile
20 25 30Glu Ala Arg Gly Glu Phe Gly Arg Phe Trp Gly Gly Ala Val Gly Gly
35 40 45Ala Ile Gly Gly Gly Val Gly Gly Ala Val Gly Gly Ala Val Gly Gly
50 55 60Pro Ala Gly Gly Trp Ala Gly Arg Leu Val Gly Gly Ser Val Gly Arg65 70 75 80Glu Phe Gly Arg Glu Ile Gly Asp Arg Val Glu Asp Tyr Ile Arg Gly
85 90 95Val Asp Arg Glu Pro Gln Ala Pro Arg Glu Pro Thr Tyr Asp Arg His
100 105 110Phe Val Tyr Asp Arg
115
(2) Sequence 25 data: (i) sequence characteristics:
(A) length: 856bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 59...802
(D) Other information: (xi) Description of the sequence: sequence 25: GCCATTTTAA GCTAATATAA TATAGAGCGA TTATCAAAAA ATAAAGGGAA AAGACTGA 58ATG TTG AAA AGA ATG ATA TTA TTA GGG GCT TTG GGT GTT TTA GCG AGC 106Met Leu Lys Arg Met Ile Leu Leu Gly Ala Leu Gly Val Leu Ala Ser 151015 GCT GAA GAG AGT GCG GCT TTT GTG GGA GTC AAT TAC CAG GTG AGC ATG 154Ala Glu Glu Ser Ala Ala Phe Val Gly Val Asn Tyr Gln Val Ser Met
20 25 30ATA CAA AAT CAG ACT AAA ATG GTG AAT GAC AAC GGC TTG CAA AAG CCT 202Ile Gln Asn Gln Thr Lys Met Val Asn Asp Asn Gly Leu Gln Lys Pro
35 40 45TTG ATA AAG TTT CCG CCT TAC GCA GGA GCG GGT TTT GAA GTG GGC TAT 250Leu Ile Lys Phe Pro Pro Tyr Ala Gly Ala Gly Phe Glu Val Gly Tyr
50 55 60AAG CAA TTT TTT GGT AAG AAA AAA TGG TTT GGC ATG CGT TAT TAT GGG 298Lys Gln Phe Phe Gly Lys Lys Lys Trp Phe Gly Met Arg Tyr Tyr Gly65 70 75 80TTT TTT GAC TAC GCG CAC AAC CGC TTT GGC GTG ATG AAA AAG GGC ATT 346Phe Phe Asp Tyr Ala His Asn Arg Phe Gly Val Met Lys Lys Gly Ile
85 90 95CCG GTG GGC GAT AGT GGG TTT ATT TAC AAT AGT TTT AGT TTT GGA GGG 394Pro Val Gly Asp Ser Gly Phe Ile Tyr Asn Ser Phe Ser Phe Gly Gly
100 105 110AAC ACT TTA ACG GAA AGG GAT TCC TAT CAG GGG CAA TAC TAT GTC AAT 442Asn Thr Leu Thr Glu Arg Asp Ser Tyr Gln Gly Gln Tyr Tyr Val Asn
115 120 125TTA TTC ACT TAT GGC GTG GGG TTA GAT ACG CTG TGG AAT TTT GTG AAT 490Leu Phe Thr Tyr Gly Val Gly Leu Asp Thr Leu Trp Asn Phe Val Asn
130 135 140AAA GAA AAC ATG GTT TTT GGT TTT GTG GTG GGG ATC CAA TTA GCG GGG 538Lys Glu Asn Met Val Phe Gly Phe Val Val Gly Ile Gln Leu Ala Gly145 150 155 160GAT AGT TGG GCA ACG AGC ATC AGT AAA GAA ATC GCT CAT TAT GCA AAA 586Asp Ser Trp Ala Thr Ser Ile Ser Lys Glu Ile Ala His Tyr Ala Lys
165 170 175CAC CAC AGC AAT TCC AGT TAT AGC CCG GCC AAT TTC CAG TTT TTA TGG 634His His Ser Asn Ser Ser Tyr Ser Pro Ala Asn Phe Gln Phe Leu Trp
180 185 190AAG TTT GGG GTC CGC ACC CAT ATC GCT AAA CAC AAT AGC CTA GAA TTA 682Lys Phe Gly Val Arg Thr His Ile Ala Lys His Asn Ser Leu Glu Leu
195 200 205GGG ATT AAA GTG CCT ACG ATC ACA CAC CAG CTT TTC TCT CTT ACC AAC 730Gly Ile Lys Val Pro Thr Ile Thr His Gln Leu Phe Ser Leu Thr Asn
210 215 220GAA AAG GGA TAC ACC TTA CAG GCT GAT GTG CGT AGA GTT TAT GCG TTT 778Glu Lys Gly Tyr Thr Leu Gln Ala Asp Val Arg Arg Val Tyr Ala Phe225 230 235 240CAA ATC AGT TAC TTG AGG GAT TTT TAACCCCTTT TTAGATACAA TCACGCCTGA AA 834Gln Ile Ser Tyr Leu Arg Asp Phe
245CTATCCATTT AAAGGTGTGA AA 856
(2) Sequence 26 data: (i) sequence characteristics:
(A) length: 248 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 26: met Leu Lys Arg Met Ile Leu Leu Gly Ala Leu Gly Val Leu Ala Ser 151015 Ala Glu Glu Ser Ala Ala Phe Val Gly Val Asn Tyr Gln Val Ser Met
20 25 30Ile Gln Asn Gln Thr Lys Met Val Asn Asp Asn Gly Leu Gln Lys Pro
35 4045Leu Ile Lys Phe Pro Pro Tyr Ala Gly Ala Gly Phe Glu Val Gly Tyr
50 55 60Lys Gln Phe Phe Gly Lys Lys Lys Trp Phe Gly Met Arg Tyr Tyr Gly65 70 75 80Phe Phe Asp Tyr Ala His Asn Arg Phe Gly Val Met Lys Lys Gly Ile
85 90 95Pro Val Gly Asp Ser Gly Phe Ile Tyr Asn Ser Phe Ser Phe Gly Gly
100 105 110Asn Thr Leu Thr Glu Arg Asp Ser Tyr Gln Gly Gln Tyr Tyr Val Asn
115 120 125Leu Phe Thr Tyr Gly Val Gly Leu Asp Thr Leu Trp Asn Phe Val Asn
130 135 140Lys Glu Asn Met Val Phe Gly Phe Val Val Gly Ile Gln Leu Ala Gly145 150 155 160Asp Ser Trp Ala Thr Ser Ile Ser Lys Glu Ile Ala His Tyr Ala Lys
165 170 175His His Ser Asn Ser Ser Tyr Ser Pro Ala Asn Phe Gln Phe Leu Trp
180 185 190Lys Phe Gly Val Arg Thr His Ile Ala Lys His Asn Ser Leu Glu Leu
195 200 205Gly Ile Lys Val Pro Thr Ile Thr His Gln Leu Phe Ser Leu Thr Asn
210 215 220Glu Lys Gly Tyr Thr Leu Gln Ala Asp Val Arg Arg Val Tyr Ala Phe225 230 235 240Gln Ile Ser Tyr Leu Arg Asp Phe
245
(2) Sequence 27 data: (i) sequence characteristics:
(A) length: 2750bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 69...2699
(D) Other information: (xi) Description of the sequence: sequence 27: TAATAATAAC CTTAGGTTTA AAACTTGACT AAATTTTTAG AAAAAAGTAA ATAAAAAGGC 60TAAAAGAA ATG CTT AGA AAT CAA TTT CGT ATC GTG TTT GTC TCT TGT ATT 110
Met Leu Arg Asn Gln Phe Arg Ile Val Phe Val Ser Cys Ile
1 5 10GTC GCT AGC AAT TTG CAA GCT CAA GAA ACA ACC CAC ACT TTG GGT AAG 158Val Ala Ser Asn Leu Gln Ala Gln Glu Thr Thr His Thr Leu Gly Lys 15 20 25 30GTA ACC ACT AAG GGT GAA AGG ACT TTT GAA TAC AAC AAT AAA ATG TAT 206Val Thr Thr Lys Gly Glu Arg Thr Phe Glu Tyr Asn Asn Lys Met Tyr
35 40 45ATT GAC AGA AAA GAG CTC CAA CAA CGC CAA AGT AAC CAA ATC CGT GAT 254Ile Asp Arg Lys Glu Leu Gln Gln Arg Gln Ser Asn Gln Ile Arg Asp
50 55 60ATT TTT AGG ACT AGA GCG GAT GTG AAT GTG GCC AGT GGG GGC TTG ATG 302Ile Phe Arg Thr Arg Ala Asp Val Asn Val Ala Ser Gly Gly Leu Met
65 70 75GCG CAA AAG ATC TAT GTT AGG GGG ATT GAG AGC CGT CTC TTA AGG GTA 350Ala Gln Lys Ile Tyr Val Arg Gly Ile Glu Ser Arg Leu Leu Arg Val
80 85 90ACA ATA GAT GGC GTC GCC CAA AAT GGT AAC ATT TTC CAC CAT GAC GCT 398Thr Ile Asp Gly Val Ala Gln Asn Gly Asn Ile Phe His His Asp Ala95 100 105 110AAC ACC GTG ATC GAT CCT AAC ATG ATT AAA GAA GTG GAA GTG ATC AAG 446Asn Thr Val Ile Asp Pro Asn Met Ile LysGlu Val Glu Val Ile Lys
115 120 125GGG GCG GCG AAC GCT TCA GCA GGC CCA GGT GCG GTG GCG GGT AAA TTG 494Gly Ala Ala Asn Ala Ser Ala Gly Pro Gly Ala Val Ala Gly Lys Leu
130 135 140TCT TTC ACC ACG ATT GAC GCT AAC GAC TTC TTA AGA AAG AAT CAA ACT 542Ser Phe Thr Thr Ile Asp Ala Asn Asp Phe Leu Arg Lys Asn Gln Thr
145 150 155TAT GGC GCT AAA GCG GAA GCG GCC TTT TAT ACC AAC TTC GGG TAT CGC 590Tyr Gly Ala Lys Ala Glu Ala Ala Phe Tyr Thr Asn Phe Gly Tyr Arg
160 165 170 ATG AAC GCC ACT GCG GCT TAC CGG GGG AAA AAC TGG GAC ATC CTA GCC 638Met Asn Ala Thr Ala Ala Tyr Arg Gly Lys Asn Trp Asp Ile Leu Ala175 180 185 190TAT TAC AAC CAT CAA AAT ATT TTT TAC TAC AGA GAC GGG AAC AAC GCT 686Tyr Tyr Asn His Gln Asn Ile Phe Tyr Tyr Arg Asp Gly Asn Asn Ala
195 200 205TTT AGG AAT GTC TTC CAC CCT AAC TAC GAT TTA CAA GAT CCA AGC AAT 734Phe Arg Asn Val Phe His Pro Asn Tyr Asp Leu Gln Asp Pro Ser Asn
210 215 220AGC GAT ATG AGC GTA GGG ACT CCC AGT GAA GTC AAT AGC GTT TTA GCT 782Ser Asp Met Ser Val Gly Thr Pro Ser Glu Val Asn Ser Val Leu Ala
225 230 235AAA ATT AAT GGC TAT ATC AAC GAA ACA GAC AGC ATT AGC GTG AGC TAC 830Lys Ile Asn Gly Tyr Ile Asn Glu Thr Asp Ser Ile Ser Val Ser Tyr
240 245 250AAC CTC ACA CGA GAC AAT TCT ACA AGG CTT TTA CGC CCT AAC ACC ACT 878Asn Leu Thr Arg Asp Asn Ser Thr Arg Leu Leu Arg Pro Asn Thr Thr255 260 265270TCA GCC CTC TCT AAA GCC AAT GAC CCA GGA AGC CAG CCA GCC CCC TTT 926Ser Ala Leu Ser Lys Ala Asn Asp Pro Gly Ser Gln Pro Ala Pro Phe
275 280 285GTG ATT GAC TTT GGG AAA GAA TTA GCC CAT ACG ATC AAC TTC AAC CAC 974Val Ile Asp Phe Gly Lys Glu Leu Ala His Thr Ile Asn Phe Asn His
290 295 300AAT TTG AGC TTG AAA TAC AAG CAT GAA GGC GGC CCT AAT TTT AAC CAG 1022Asn Leu Ser Leu Lys Tyr Lys His Glu Gly Gly Pro Asn Phe Asn Gln
305 310 315CCG CGC GTT GAA TCC ACC GCC TTT TTA GGG GTA AGG GGG GGC AAT TAT 1070Pro Arg Val Glu Ser Thr Ala Phe Leu Gly Val Arg Gly Gly Asn Tyr
320 325 330AAC CCT GTG GTG AAT CCT TTC GCT TAC AAT TCT AAC GAG CCG GCT AAC 1118Asn Pro Val Val Asn Pro Phe Ala Tyr Asn Ser Asn Glu Pro Ala Asn335 340 345 350CCA GAT TAT ATC CCT GAA GTG AAA GAG TGG TGT AAT AAC CCA GAT AAT 1166Pro Asp Tyr Ile Pro Glu Val Lys Glu Trp Cys Asn Asn Pro Asp Asn
355 360 365ATC AGC CAG TGC ACG CAA GGG GCT ATC AGG CCT TCT AAT GGA GGC TAT 1214Ile Ser Gln Cys Thr Gln Gly Ala Ile Arg Pro Ser Asn Gly Gly Tyr
370 375 380CAA ATA GGC TAT GGC ACG CCT AAT TCT ATT AAT TGG CAA GGG ACT AGC 1262Gln Ile Gly Tyr Gly Thr Pro Asn Ser Ile Asn Trp Gln Gly Thr Ser
385 390 395GAT TCT AGT GGA GGG GCG CAA GCA GGG TAT GGG CAG CTT AAC GCT ATT 1310Asp Ser Ser Gly Gly Ala Gln Ala Gly Tyr Gly Gln Leu Asn Ala Ile
400 405 410TCT ACA AGC GCG AAC GTT TAT CAT GGG CTT GTC CCT AAA AAT CCT GAT 1358SerThr Ser Ala Asn Val Tyr His Gly Leu Val Pro Lys Asn Pro Asp415 420 425 430TAT GAC ATG ACC CCC CCT AAC GCT CAA AAC CCT AGC GCA AAC GAT TGG 1406Tyr Asp Met Thr Pro Pro Asn Ala Gln Asn Pro Ser Ala Asn Asp Trp
435 440 445ACT TTA GGG AAT GCG GAC GCT GAG GGG ACT TTA GCC AGA AGG ATT TTT 1454Thr Leu Gly Asn Ala Asp Ala Glu Gly Thr Leu Ala Arg Arg Ile Phe
450 455 460TTA ATC AAC TCG GGC GTT AAT TTT AAA GTA ACC CAC CCC ATT AGC GAA 1502Leu Ile Asn Ser Gly Val Asn Phe Lys Val Thr His Pro Ile Ser Glu
465 470 475GAT TAT GGG AAT GTG TTT GAA TAC GGC ATG ATT TAT CAA AAC CTG AGC 1550Asp Tyr Gly Asn Val Phe Glu Tyr Gly Met Ile Tyr Gln Asn Leu Ser
480 485 490GTT TTC TCT GGA TTG GAT AAA GGC AAA AAC GGC TAT TAT AAA AAC AAC 1598Val Phe Ser Gly Leu Asp Lys Gly Lys Asn Gly Tyr Tyr Lys Asn Asn495 500 505 510ATT GAT CCT AAC GAC CCT AAC GGG CCG GGC TTG CCT TAC CGC CAT TAC 1646Ile Asp Pro Asn Asp Pro Asn Gly Pro Gly Leu Pro Tyr Arg His Tyr
515 520 525TAC ACC GAT CAA AGC TCC CAA TAC CCC CAA AAT CTC AAC ACC CCT AAC 1694Tyr Thr Asp Gln Ser Ser Gln Tyr Pro Gln Asn Leu Asn Thr Pro Asn
530 535 540CCG CTC TAT CGT AAC ATG CCC CAA AAT TCG CAT GCG ATC GGC AAT ATC 1742Pro Leu Tyr Arg Asn Met Pro Gln Asn Ser His Ala Ile Gly Asn Ile
545 550 555ATC GGA GGG TTT ATG CAA GCA AAC TAC AAC ATT TTA AGC AAT GTG ATC 1790Ile Gly Gly Phe Met Gln Ala Asn Tyr Asn Ile Leu Ser Asn Val Ile
560 565 570GTG GGT GCG GGA ACT CGT TAT GAT ATT TAC ACC TTG CTA GAC AAA AAC 1838Val Gly Ala Gly Thr Arg Tyr Asp Ile Tyr Thr Leu Leu Asp Lys Asn575 580 585 590GGC CGC ACG CAT GTA ACT TCT GGT TTC TCG CCT TCT GCA ACC GTG CTT 1886Gly Arg Thr His Val Thr Ser Gly Phe Ser Pro Ser Ala Thr Val Leu
595 600 605TAT AAC CCC ATT GAA AGC ATT GGC TTG AAA GTG AGT TAT GCG TAT GTA 1934Tyr Asn Pro Ile Glu Ser Ile Gly Leu Lys Val Ser Tyr Ala Tyr Val
610 615 620ACT AAG GGG GCT TTG CCT GGC GAT GGC GTT TTG ATG CGC GAT CCT ACG 1982Thr Lys Gly Ala Leu Pro Gly Asp Gly Val Leu Met Arg Asp Pro Thr
625 630 635GTG ATT TAT CAA AGG AAT TTG CGC CCT GCG ATC GGT CAA AAT GTG GAA 2030Val Ile Tyr Gln Arg Asn Leu Arg Pro Ala Ile Gly Gln Asn Val Glu
640 645 650TTT AAT GTG GAT TTC AAC AGC AAG TAT TTC AAT GTG CGC GGG GCA GCG 2078Phe Asn Val Asp Phe Asn Ser Lys Tyr Phe Asn Val Arg Gly Ala Ala655 660 665 670TTC TAT CAA GTC ATC AAT AAT TTC ATC AAC AGC TAC GGG CAA GAC ACT 2126Phe Tyr Gln Val Ile Asn Asn Phe Ile Asn Ser Tyr Gly Gln Asp Thr
675 680 685TCT AAA AAT GGA GGG GGT AAC GCA ACC GCA AAA AAC ATG TCA GGG AAT 2174Ser Lys Asn Gly Gly Gly Asn Ala Thr Ala Lys Asn Met Ser Gly Asn
690 695 700TTA CCC GAA ACC ATT AAC ATT TAT GGT TAT GAA GTT TCA GGG AAT GTG 2222Leu Pro Glu Thr Ile Asn Ile Tyr Gly Tyr Glu Val Ser Gly Asn Val
705 710 715AGG TAT AAG AAT TTC TTA GGG ACT TTC TCA GTG GCT CGC TCT TGG CCA2270Arg Tyr Lys Asn Phe Leu Gly Thr Phe Ser Val Ala Arg Ser Trp Pro
720 725 730ACG GCT AGG GGG CAT TTA TTA GCG GAC ACT TAC GCT CTA GCT GCA ACG 2318Thr Ala Arg Gly His Leu Leu Ala Asp Thr Tyr Ala Leu Ala Ala Thr735 740 745 750ACT GGG AAT GTG TTT ATT TTA AAA GCC GAT TAT GAT GTT CGC AGG TGG 2366Thr Gly Asn Val Phe Ile Leu Lys Ala Asp Tyr Asp Val Arg Arg Trp
755 760 765GGG CTT ACT TTA ACC TGG CTC TCG CGC TTT GTA ACT AAC ATG TAT TAT 2414Gly Leu Thr Leu Thr Trp Leu Ser Arg Phe Val Thr Asn Met Tyr Tyr
770 775 780GAG GGC TAT TCT ATC TAT TAC CCG CAA TAC GGC TTG ATC AAA ATC CAT 2462Glu Gly Tyr Ser Ile Tyr Tyr Pro Gln Tyr Gly Leu Ile Lys Ile His
785 790 795AAA CCC GGG TAT GGC GTG CAT AAT GTC TTT ATC AAC TGG ACT CCG CCT 2510Lys Pro Gly Tyr Gly Val His Asn Val Phe Ile Asn Trp Thr Pro Pro
800 805 810TCT AAA AAA TGG CAG GGT TTA AGG ATT TCA GCC GTG TTT AAT AAT ATC 2558Ser Lys Lys Trp Gln Gly Leu Arg Ile Ser Ala Val Phe Asn Asn Ile815 820 825 830TTA AAC AAG CAA TAT GTG GAT CAA ACT TCT GTG TTT CAA GCG AGC GCG 2606Leu Asn Lys Gln Tyr Val Asp Gln Thr Ser Val Phe Gln Ala Ser Ala
835 840 845GAC GCT CCA GCG AGC GAT ATG ATC CCT AAA GGT AAG CGC ATG GCG CTC 2654Asp Ala Pro Ala Ser Asp Met Ile Pro Lys Gly Lys Arg Met Ala Leu
850 855 860CCG GCT CCT GGA TTT AAC GCG CGT TTT GAG GTA TCC TAT CAG TTC TAAAA 2704Pro Ala Pro Gly Phe Asn Ala Arg Phe Glu Val Ser Tyr Gln Phe
865 870 875TGAAAGGAAT CTTAGGATTT CTTTTTGAAT TTTGAACATG GAAACA 2750
(2) Data for sequence 28: (i) sequence characteristics:
(A) length: 877 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 28: met Leu Arg Asn Gln Phe Arg Ile Val Phe Val Ser Cys Ile Val Ala 151015 Ser Asn Leu Gln Ala Gln Glu Thr Thr His Thr Leu Gly Lys Val Thr
20 25 30Thr Lys Gly Glu Arg Thr Phe Glu Tyr Asn Asn Lys Met Tyr Ile Asp
35 40 45Arg Lys Glu Leu Gln Gln Arg Gln Ser Asn Gln Ile Arg Asp Ile Phe
50 55 60Arg Thr Arg Ala Asp Val Asn Val Ala Ser Gly Gly Leu Met Ala Gln 65 70 75 80Lys Ile Tyr Val Arg Gly Ile Glu Ser Arg Leu Leu Arg Val Thr Ile
85 90 95Asp Gly Val Ala Gln Asn Gly Asn Ile Phe His His Asp Ala Asn Thr
100 105 110Val Ile Asp Pro Asn Met Ile Lys Glu Val Glu Val Ile Lys Gly Ala
115 120 125Ala Asn Ala Ser Ala Gly Pro Gly Ala Val Ala Gly Lys Leu Ser Phe
130 135 140Thr Thr Ile Asp Ala Asn Asp Phe Leu Arg Lys Asn Gln Thr Tyr Gly145 150 155 160Ala Lys Ala Glu Ala Ala Phe Tyr Thr Asn Phe Gly Tyr Arg Met Asn
165 170175Ala Thr Ala Ala Tyr Arg Gly Lys Asn Trp Asp Ile Leu Ala Tyr Tyr
180 185 190Asn His Gln Asn Ile Phe Tyr Tyr Arg Asp Gly Asn Asn Ala Phe Arg
195 200 205Asn Val Phe His Pro Asn Tyr Asp Leu Gln Asp Pro Ser Asn Ser Asp
210 215 220Met Ser Val Gly Thr Pro Ser Glu Val Asn Ser Val Leu Ala Lys Ile225 230 235 240Asn Gly Tyr Ile Asn Glu Thr Asp Ser Ile Ser Val Ser Tyr Asn Leu
245 250 255Thr Arg Asp Asn Ser Thr Arg Leu Leu Arg Pro Asn Thr Thr Ser Ala
260 265 270Leu Ser Lys Ala Asn Asp Pro Gly Ser Gln Pro Ala Pro Phe Val Ile
275 280 285Asp Phe Gly Lys Glu Leu Ala His Thr Ile Asn Phe Asn His Asn Leu
290 295 300Ser Leu Lys Tyr Lys His Glu Gly Gly Pro Asn Phe Asn Gln Pro Arg305 310 315 320Val Glu Ser Thr Ala Phe Leu Gly Val Arg Gly Gly Asn Tyr Asn Pro
325 330 335Val Val Asn Pro Phe Ala Tyr Asn Ser Asn Glu Pro Ala Asn Pro Asp
340 345 350Tyr Ile Pro Glu Val Lys Glu Trp Cys Asn Asn Pro Asp Asn Ile Ser
355 360 365Gln Cys Thr Gln Gly Ala Ile Arg Pro Ser Asn Gly Gly Tyr Gln Ile
370 375 380Gly Tyr Gly Thr Pro Asn Ser Ile Asn Trp Gln Gly Thr Ser Asp Ser385 390 395 400Ser Gly Gly Ala Gln Ala Gly Tyr Gly Gln Leu Asn Ala Ile Ser Thr
405 410 415Ser Ala Asn Val Tyr His Gly Leu Val Pro Lys Asn Pro Asp Tyr Asp
420 425 430Met Thr Pro Pro Asn Ala Gln Asn Pro Ser Ala Asn Asp Trp Thr Leu
435 440 445Gly Asn Ala Asp Ala Glu Gly Thr Leu Ala Arg Arg Ile Phe Leu Ile
450 455 460Asn Ser Gly Val Asn Phe Lys Val Thr His Pro Ile Ser Glu Asp Tyr465 470 475 480Gly Asn Val Phe Glu Tyr Gly Met Ile Tyr Gln Asn Leu Ser Val Phe
485 490 495Ser Gly Leu Asp Lys Gly Lys Asn Gly Tyr Tyr Lys Asn Asn Ile Asp
500 505 510Pro Asn Asp Pro Asn Gly Pro Gly Leu Pro Tyr Arg His Tyr Tyr Thr
515 520 525Asp Gln Ser Ser Gln Tyr Pro Gln Asn Leu Asn Thr Pro Asn Pro Leu
530 535 540Tyr Arg Asn Met Pro Gln Asn Ser His Ala Ile Gly Asn Ile Ile Gly545 550 555 560Gly Phe Met Gln Ala Asn Tyr Asn Ile Leu Ser Asn Val Ile Val Gly
565 570 575Ala Gly Thr Arg Tyr Asp Ile Tyr Thr Leu Leu Asp Lys Asn Gly Arg
580 585 590Thr His Val Thr Ser Gly Phe Ser Pro Ser Ala Thr Val Leu Tyr Asn
595 600 605Pro Ile Glu Ser Ile Gly Leu Lys Val Ser Tyr Ala Tyr Val Thr Lys
610 615 620Gly Ala Leu Pro Gly Asp Gly Val Leu Met Arg Asp Pro Thr Val Ile625 630 635 640Tyr Gln Arg Asn Leu Arg Pro Ala Ile Gly Gln Asn Val Glu Phe Asn
645 650 655Val Asp Phe Asn Ser Lys Tyr Phe Asn Val Arg Gly Ala Ala Phe Tyr
660 665 670Gln Val Ile Asn Asn Phe Ile Asn Ser Tyr Gly Gln Asp Thr Ser Lys
675 680 685Asn Gly Gly Gly Asn Ala Thr Ala Lys Asn Met Ser Gly Asn Leu Pro
690 695 700Glu Thr Ile Asn Ile Tyr Gly Tyr Glu Val Ser Gly Asn Val Arg Tyr705 710 715 720Lys Asn Phe Leu Gly Thr Phe Ser Val Ala Arg Ser Trp Pro Thr Ala
725 730 735Arg Gly His Leu Leu Ala Asp Thr Tyr Ala Leu Ala Ala Thr Thr Gly
740 745 750Asn Val Phe Ile Leu Lys Ala Asp Tyr Asp Val Arg Arg Trp Gly Leu
755 760 765Thr Leu Thr Trp Leu Ser Arg Phe Val Thr Asn Met Tyr Tyr Glu Gly
770 775 780Tyr Ser Ile Tyr Tyr Pro Gln Tyr Gly Leu Ile Lys Ile His Lys Pro785 790 795 800Gly Tyr Gly Val His Asn Val Phe Ile Asn Trp Thr Pro Pro Ser Lys
805 810 815Lys Trp Gln Gly Leu Arg Ile Ser Ala Val Phe Asn Asn Ile Leu Asn
820 825 830Lys Gln Tyr Val Asp Gln Thr Ser Val Phe Gln Ala Ser Ala Asp Ala
835 840 845Pro Ala Ser Asp Met Ile Pro Lys Gly Lys Arg Met Ala Leu Pro Ala
850 855 860Pro Gly Phe Asn Ala Arg Phe Glu Val Ser Tyr Gln Phe865 870 875
(2) Sequence 29 data:
(i) sequence characteristics:
(A) length: 370bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...317
(D) Other information:
(xi) Description of the sequence: sequence 29: TTTAAAATCA CCCGTTACAG CATCACTGAA ATCACTAATA GGGGTGATTG ATG CGT 56
Met Arg
1AAG GTT TTA TAC GCT CTT GTG GGC TTT TTG TTG GCT TTT AGC GCT TTA 104Lys Val Leu Tyr Ala Leu Val Gly Phe Leu Leu Ala Phe Ser Ala Leu
5 10 15AAA GCC GAT GAT TTT TTA GAA GAA GCG AAC GAA ACA GCC CCG GCG CAT 152Lys Ala Asp Asp Phe Leu Glu Glu Ala Asn Glu Thr Ala Pro Ala His
20 25 30TTA AAC CAC CCT ATG CAG GAT TTA AAC GCC ATT CAA GGG AGC TTT TTT 200Leu Asn His Pro Met Gln Asp Leu Asn Ala Ile Gln Gly Ser Phe Phe 35 40 45 50GAC AAA AAC CGC TCA AAA ATG TCC AAC ACT TTG AAC ATT GAT TAC TTT 248Asp Lys Asn Arg Ser Lys Met Ser Asn Thr Leu Asn Ile Asp Tyr Phe
55 60 65CAA GGG CAA ACT TAT AAA ATC CCG CTT GCG TTA TGC GAT GGC GMC CTT296Gln Gly Gln Thr Tyr Lys Ile Pro Leu Ala Leu Cys Asp Gly Xaa Leu
70 75 80ATT GTT TTT TTC AAA ACC CAT TAGCGATTTT GTTTTAGGGG ATAAGGTGGG TTTT 351Ile Val Phe Phe Lys Thr His
85GATGCGAAAA TTTTAGAAA 370
(2) Sequence 30 data: (i) sequence characteristics:
(A) length: 89 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 30: met Arg Lys Val Leu Tyr Ala Leu Val Gly Phe Leu Leu Ala Phe Ser 151015 Ala Leu Lys Ala Asp Asp Phe Leu Glu Glu Ala Asn Glu Thr Ala Pro
20 25 30Ala His Leu Asn His Pro Met Gln Asp Leu Asn Ala Ile Gln Gly Ser
35 40 45Phe Phe Asp Lys Asn Arg Ser Lys Met Ser Asn Thr Leu Asn Ile Asp
50 55 60Tyr Phe Gln Gly Gln Thr Tyr Lys Ile Pro Leu Ala Leu Cys Asp Gly 65 70 75 80Xaa Leu Ile Val Phe Phe Lys Thr His
85
(2) Sequence 31 data: (i) sequence characteristics:
(A) length: 357bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...305
(D) Other information: (xi) Description of the sequence: sequence 31: ATGCAATAAA AAAAGAAATT CTTAGGATTT CTCACATTAA GGAGTTTTAA ATG AAA 56
Met Lys
1AAG GTT TTT TTA GGT ATG GCA TTA GCC TTT AGT GTG TCC ATG GCA GAA 104Lys Val Phe Leu Gly Met Ala Leu Ala Phe Ser Val Ser Met Ala Glu
5 10 15AAA AGT GGC GCG TTT TTA GGA GGG GGG TTT CAA TAT TCT AAT TTA GAA 152Lys Ser Gly Ala Phe Leu Gly Gly Gly Phe Gln Tyr Ser Asn Leu Glu
20 25 30AAC CAA AAC ACC ACC CGC ACC CCA GGC GCT AAC AAT AAC ACC CCG ATA 200Asn Gln Asn Thr Thr Arg Thr Pro Gly Ala Asn Asn Asn Thr Pro Ile35 40 45 50GAC ACT TCA ATG TTT GGC AGC AAC AAA ACA GCT CCA GCC CAA GAA ACG 248Asp Thr Ser Met Phe Gly Ser Asn Lys Thr Ala Pro Ala Gln Glu Thr
55 60 65CAA AGC GCT TCC AAA CCG GAC ACT AAA GTC AAT CCA AGC GCA AGT TGG 296Gln Ser Ala Ser Lys Pro Asp Thr Lys Val Asn Pro Ser Ala Ser Trp
70 75 80ATG AAA AAA TAAGAAGGAA GTTATGAAAA AGTCATTCAA AAAATTAGGC TTTGTCTCT 354Met Lys Lys
85TTA 357
(2) Sequence 32 data: (i) sequence characteristics:
(A) length: 85 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 32: met Lys Lys Val Phe Leu Gly Met Ala Leu Ala Phe Ser Val Ser Met 151015 Ala Glu Lys Ser Gly Ala Phe Leu Gly Gly Gly Phe Gln Tyr Ser Asn
20 25 30Leu Glu Asn Gln Asn Thr Thr Arg Thr Pro Gly Ala Asn Asn Asn Thr
35 40 45Pro Ile Asp Thr Ser Met Phe Gly Ser Asn Lys Thr Ala Pro Ala Gln
50 55 60Glu Thr Gln Ser Ala Ser Lys Pro Asp Thr Lys Val Asn Pro Ser Ala65 70 75 80Ser Trp Met Lys Lys
85
(2) Sequence 33 data:
(i) sequence characteristics:
(A) length: 961bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...908
(D) Other information:
(xi) Description of the sequence: sequence 33: GAATGTAGCA TTTAGAACTC AAGTAGAGAA AATGTAGAAG GAAGGAATAC ATG AAG 56
Met Lys
1AAA TCT GTT ATA GTA GGT GCT ATC TCT CTA GCA ATG ACA AGC TTA TTG 104Lys Ser Val Ile Val Gly Ala Ile Ser Leu Ala Met Thr Ser Leu Leu
5 10 15TCA GCA GAG ACC CCT AAG CAA GAA AAA GCT ATT AAG ACT AGC CCT ACC 152Ser Ala Glu Thr Pro Lys Gln Glu Lys Ala IleLys Thr Ser Pro Thr
20 25 30AAA AAA GGT GAA AGA AAT GCT GCT TTT ATA GGG ATT GAT TAC CAG TTG 200Lys Lys Gly Glu Arg Asn Ala Ala Phe Ile Gly Ile Asp Tyr Gln Leu35 40 45 50GGT ATG CTC AGC ACT ACC GCT CAA AAT TGT TCC CAT GGG AAT TGC AAT 248Gly Met Leu Ser Thr Thr Ala Gln Asn Cys Ser His Gly Asn Cys Asn
55 60 65GGT AAT CAA AGT GGG GCT TAC GGC TCT AAT ACG CCT AAC ATG CCT ACA 296Gly Asn Gln Ser Gly Ala Tyr Gly Ser Asn Thr Pro Asn Met Pro Thr
70 75 80GCG TCA AAC CCA ACA GGA GGG TTT ACT CAT GGC GCT CTA GGG ACT CGT 344Ala Ser Asn Pro Thr Gly Gly Phe Thr His Gly Ala Leu Gly Thr Arg
85 90 95GGG TAT AAA GGC TTA AGC AAC CAA CAA TAC GCT ATC AAT GGT TTT GGT 392Gly Tyr Lys Gly Leu Ser Asn Gln Gln Tyr Ala Ile Asn Gly Phe Gly
100 105 110TTT GTT GTA GGG TAT AAG CAT TTT TTC AAG AAA TCC CCG CAA TTT GGA 440Phe Val Val Gly Tyr Lys His Phe Phe Lys Lys Ser Pro Gln Phe Gly115 120 125 130ATG CGT TAT TAC GGA TTC TTT GAT TTT GCA AGC TCT TAT TAT AAG TAT 488Met Arg Tyr Tyr Gly Phe Phe Asp Phe Ala Ser Ser Tyr Tyr Lys Tyr
135 140 145TAC ACT TAT AAT GAT TAT GGC ATG AGA GAC GCT CGC AAG GGT TCT CAA 536Tyr Thr Tyr Asn Asp Tyr Gly Met Arg Asp Ala Arg Lys Gly Ser Gln
150 155 160AGT TTC ATG TTT GGC TAT GGG GCT GGC ACA GAT GTG TTG TTT AAC CCG 584Ser Phe Met Phe Gly Tyr Gly Ala Gly Thr Asp Val Leu Phe Asn Pro
165 170 175GCT ATT TTC AAT CGT GAG AAC TTG CAT TTT GGG TTT TTC TTG GGC GTT 632Ala Ile Phe Asn Arg Glu Asn Leu His Phe Gly Phe Phe Leu Gly Val
180 185 190GCG ATC GGT GGC ACC TCT TGG GGT CCA ACA AAC TAT TAT TTT AAG GAC 680Ala Ile Gly Gly Thr Ser Trp Gly Pro Thr Asn Tyr Tyr Phe Lys Asp195 200 205 210TTG GCT GAT GAG TAT AGA GGG AGT TTC CAC CCA TCA AAT TTC CAG GTC 728Leu Ala Asp Glu Tyr Arg Gly Ser Phe His Pro Ser Asn Phe Gln Val
215 220 225TTA GTT AAT GGT GGG ATT CGC TTA GGC ACT AAA CAC CAA GGT TTT GAA 776Leu Val Asn Gly Gly Ile Arg Leu Gly Thr Lys His Gln Gly Phe Glu
230 235 240ATT GGC TTG AAA ATC CAA ACC ATC CGC AAC AAT TAC TAC ACC GCT AGT 824Ile Gly Leu Lys Ile Gln Thr Ile Arg Asn Asn Tyr Tyr Thr Ala Ser
245 250 255GCG GAT AAT GTG CCT GAA GGG ACT ACT TAT AGA TTC ACT TTC CAC CGC 872Ala Asp Asn Val Pro Glu Gly Thr Thr Tyr Arg Phe Thr Phe His Arg
260 265 270CCC TAT GCC TTT TAT TGG CGT TAC ATT GTA AGC TTT TAAGGTGTTT TAGGGC 924Pro Tyr Ala Phe Tyr Trp Arg Tyr Ile Val Ser Phe275 280 285TAATCTTATG GGGGCATAGA AAAGGGCTTT TGCTCTT 961
(2) Sequence 34 data: (i) sequence characteristics:
(A) length: 286 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 34: met Lys Lys Ser Val Ile Val Gly Ala Ile Ser Leu Ala Met Thr Ser 151015 Leu Leu Ser Ala GluThr Pro Lys Gln Glu Lys Ala Ile Lys Thr Ser
20 25 30Pro Thr Lys Lys Gly Glu Arg Asn Ala Ala Phe Ile Gly Ile Asp Tyr
35 40 45Gln Leu Gly Met Leu Ser Thr Thr Ala Gln Asn Cys Ser His Gly Asn
50 55 60Cys Asn Gly Asn Gln Ser Gly Ala Tyr Gly Ser Asn Thr Pro Asn Met65 70 75 80Pro Thr Ala Ser Asn Pro Thr Gly Gly Phe Thr His Gly Ala Leu Gly
85 90 95Thr Arg Gly Tyr Lys Gly Leu Sar Asn Gln Gln Tyr Ala Ile Asn Gly
100 105 110Phe Gly Phe Val Val Gly Tyr Lys His Phe Phe Lys Lys Ser Pro Gln
115 120 125Phe Gly Met Arg Tyr Tyr Gly Phe Phe Asp Phe Ala Ser Sar Tyr Tyr
130 135 140Lys Tyr Tyr Thr Tyr Asn Asp Tyr Gly Met Arg Asp Ala Arg Lys Gly145 150 155 160Ser Gln Ser Phe Met Phe Gly Tyr Gly Ala Gly Thr Asp Val Leu Phe
165 170 175Asn Pro Ala Ile Phe Asn Arg Glu Asn Leu His Phe Gly Phe Phe Leu
180 185 190Gly Val Ala Ile Gly Gly Thr Ser Trp Gly Pro Thr Asn Tyr Tyr Phe
195 200 205Lys Asp Leu Ala Asp Glu Tyr Arg Gly Ser Phe His Pro Ser Asn Phe
210 215 220Gln Val Leu Val Asn Gly Gly Ile Arg Leu Gly Thr Lys His Gln Gly225 230 235 240Phe Glu Ile Gly Leu Lys Ile Gln Thr Ile Arg Asn Asn Tyr Tyr Thr
245 250 255Ala Ser Ala Asp Asn Val Pro Glu Gly Thr Thr Tyr Arg Phe Thr Phe
260 265 270His Arg Pro Tyr Ala Phe Tyr Trp Arg Tyr Ile Val Ser Phe
275 280 285
(2) Sequence 35 data: (i) sequence characteristics:
(A) length: 289bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...236
(D) Other information: (xi) Description of the sequence: sequence 35: GGGATTTTAT TTCTTATAGC AGAAATTATT TTTAAAGTAA AAGACAAATC ATG TTT 56
Met Phe
1AGA GAT ATA GTA GAT ATT TTA ATA TCT GTT GTT ATT ATT GGA TTA GTA 104Arg Asp Ile Val Asp Ile Leu Ile Ser Val Val Ile Ile Gly Leu Val
5 10 15TTA ACA GCT ATT AGA GCT ACT ATA ATG GCG TTT AAA GGC GAT ACT GAT 152Leu Thr Ala Ile Arg Ala Thr Ile Met Ala Phe Lys Gly Asp Thr Asp
20 25 30GAT GAT GAA GTT GAG AGT GAT GGG TTT TTT AGT AGA ATA TGG GAT AAA 200Asp Asp Glu Val Glu Ser Asp Gly Phe Phe Ser Arg Ile Trp Asp Lys35 40 45 50TTC GTT GAA TAT TTC GGC TAT ACT CTA GTT ACT ATA TAATGTTTTT TCCTTA 252Phe Val Glu Tyr Phe Gly Tyr Thr Leu Val Thr Ile
55 60TATAATTGGA CCAGTTATCG CTTTAATTTT TATATTT 289
(2) Sequence 36 data: (i) sequence characteristics:
(A) length: 62 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: inner part
(xi) Description of the sequence: sequence 36: met Phe Arg Asp Ile Val Asp Ile Leu Ile Ser Val Val Ile Ile Gly 151015 Leu Val Leu Thr Ala Ile Arg Ala Thr Ile Met Ala Phe Lys Gly Asp
20 25 30Thr Asp Asp Asp Glu Val Glu Ser Asp Gly Phe Phe Ser Arg Ile Trp
35 40 45Asp Lys Phe Val Glu Tyr Phe Gly Tyr Thr Leu Val Thr Ile
50 55 60
(2) Data for sequence 37:
(i) sequence characteristics:
(A) length: 1544bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...1491
(D) Other information:
(xi) Description of the sequence: sequence 37: GACACACATT AGTTATAGTT TCTAAGAGAG TTCTCCCCCT ATCTCTTAGA T ATG CCT 57
Met Pro
1TTT TGT ATT TTT ATT TTA ATA TCT TTG GGA GTT AGG GTT TTG GAA ATT 105Phe Cys Ile Phe Ile Leu Ile Ser Leu Gly Val Arg Val Leu Glu Ile
5 10 15AAG AAA TAT TTT TCT TAC TCT CTA TTT TTT TTG CTT TTT TCT AGT CTC 153Lys Lys Tyr Phe Ser Tyr Ser Leu Phe Phe Leu Leu Phe Ser Ser Leu
20 25 30TTT TTA TCC AAA CTT CAA GCT TAT AAA TTC AAC ATG AGC ATT GTT GGA 201Phe Leu Ser Lys Leu Gln Ala Tyr Lys Phe Asn Met Ser Ile Val Gly35 40 45 50AAG GTG AGC AGC TAT ACC AAG TTT GGC TTT AAC AAC CAA AGA TAC CAG 249Lys Val Ser Ser Tyr Thr Lys Phe Gly Phe Asn Asn Gln Arg Tyr Gln
55 60 65CCT TCT AAA GAC ATT TAT CCT ACA GGT AGC TAC ACT TCT TTA CTC GGC 297Pro Ser Lys Asp Ile Tyr Pro Thr Gly Ser Tyr Thr Ser Leu Leu Gly
70 75 80GAA TTG AAT TTG AGC ATG GGT TTA TAC AAG GGT TTG AGA GCG GAA GTG 345Glu Leu Asn Leu Ser Met Gly Leu Tyr Lys Gly Leu Arg Ala Glu Val
85 90 95GGG GCT ATG ATG GCA GCG CTC CCC TAT GAC TCT ACC GCC TAT CAA GGC 393Gly Ala Met Met Ala Ala Leu Pro Tyr Asp Ser Thr Ala Tyr Gln Gly
100 105 110AAC AAT ATC CCT AAC GGC CAG CCC GGC TCT AGG ACC GAT CCT TTT GGG 441Asn Asn Ile Pro Asn Gly Gln Pro Gly Ser Arg Thr Asp Pro Phe Gly115 120 125 130GCG GGT ATC TTT TGG CAA TAT ATT GGT TGG TAT GCG GGG CAT AGT GGT 489Ala Gly Ile Phe Trp Gln Tyr Ile Gly Trp Tyr Ala Gly His Ser Gly
135 140 145TTG CAA GTG CAA AAA CCT CGT TTA GCC ATG GTG CAT AAC GCT TTTTTG 537Leu Gln Val Gln Lys Pro Arg Leu Ala Met Val His Asn Ala Phe Leu
150 155 160AGC TAC AAC TAC AAA AAA GAC AAA TTC AGT TTT GGC GTG AAA GGG GGG 585Ser Tyr Asn Tyr Lys Lys Asp Lys Phe Ser Phe Gly Val Lys Gly Gly
165 170 175CGC TAT GAC GCT GAA GAG TAT GAT TGG TTC ACT TCT TAC ACT CAA GGG 633Arg Tyr Asp Ala Glu Glu Tyr Asp Trp Phe Thr Ser Tyr Thr Gln Gly
180 185 190GTT GAA GGC TTT GTC AAA TAT AAA GAC ACC AGA TTC AGG GTG ATG TAT 681Val Glu Gly Phe Val Lys Tyr Lys Asp Thr Arg Phe Arg Val Met Tyr195 200 205 210TCA GAC GCT AGG GCT TCA GCG TCA AGC GAC TGG TTT TGG TAT TTT GGG 729Ser Asp Ala Arg Ala Ser Ala Ser Ser Asp Trp Phe Trp Tyr Phe Gly
215 220 225CGT TAC TAT ACA AGC GGT AAG GCT CTA ATG GTA GCT GAT TTG AAA TAT 777Arg Tyr Tyr Thr Ser Gly Lys Ala Leu Met Val Ala Asp Leu Lys Tyr
230 235 240GAA AAA GAC AAC CTA AAA ATC AAC CCT TAT TTT TAT GCG ATC TTT CAA 825Glu Lys Asp Asn Leu Lys Ile Asn Pro Tyr Phe Tyr Ala Ile Phe Gln
245 250 255AGA ATG TAT GCG CCA GGC ATT AAT ATC ACT TAT GAC ACC AAC CCT AAT 873Arg Met Tyr Ala Pro Gly Ile Asn Ile Thr Tyr Asp Thr Asn Pro Asn
260 265 270TTC AAC AAT AAG GGT TTT CGT TTT GTA GGC ACT TTC GTA GGG TTT TTC 921Phe Asn Asn Lys Gly Phe Arg Phe Val Gly Thr Phe Val Gly Phe Phe275 280 285 290CCC ATT TTT GCC ACT CCG GCT AAT CAA AAT GAT ATT ATC CTC TTC CAA 969Pro Ile Phe Ala Thr Pro Ala Asn Gln Asn Asp Ile Ile Leu Phe Gln
295 300 305CAA GTG CCA TTA GGC AAG AGT GGG CAA ACT TAT TTC TTC CGC ACT CGT 1017Gln Val Pro Leu Gly Lys Ser Gly Gln Thr Tyr Phe Phe Arg Thr Arg
310 315 320TTT TAC TAT AAT AAG TGG CAA TTT GGG GGC AGC GTC TAT AAA AAC ATC 1065Phe Tyr Tyr Asn Lys Trp Gln Phe Gly Gly Ser Val Tyr Lys Asn Ile
325 330 335GGT AAC GCT AAT GGT GAT ATA GGT ATT TAT GGC GAC CCT TTG GGG TAT 1113Gly Asn Ala Asn Gly Asp Ile Gly Ile Tyr Gly Asp Pro Leu Gly Tyr
340 345 350AAC ATT TGG ACG AAT AGT ATT TAT GAC GCA GAA ATT AAC AAT ATT GTT 1161Asn Ile Trp Thr Asn Ser Ile Tyr Asp Ala Glu Ile Asn Asn Ile Val355 360 365 370GGC GCT GAT GTT ATT AAC GGG TTT TTG TAT GTA GGC TCA CAA TAT AGA 1209Gly Ala Asp Val Ile Asn Gly Phe Leu Tyr Val Gly Ser Gln Tyr Arg
375 380 385GGG TTT AGT TGG AAA ATT TTA GGC CGT TGG ACG GAT AGC CCA AGG GCT 1257Gly Phe Ser Trp Lys Ile Leu Gly Arg Trp Thr Asp Ser Pro Arg Ala
390 395 400GAT GAA AGG AGT CTC GCG CTC TTT TTG AGT TAT TTT TCT AAT AAG TAT 1305Asp Glu Arg Ser Leu Ala Leu Phe Leu Ser Tyr Phe Ser Asn Lys Tyr
405 410 415AAT ATT AGA ATG GAT TTA AAA CTA GAA TAT TAT GGC AAT ATC ACC AAA 1353Asn Ile Arg Met Asp Leu Lys Leu Glu Tyr Tyr Gly Asn Ile Thr Lys
420 425 430AAA GGC TAT TGT ATT GGG TAT TGT GGC ATG TAT GTT CCA GTC GAT CCT 1401Lys Gly Tyr Cys Ile Gly Tyr Cys Gly Met Tyr Val Pro Val Asp Pro435 440 445 450AAC GGG CCT GGG ACA CAG CCT TTA ACGCAC AAT GTG TAT TCT GAC AGG 1449Asn Gly Pro Gly Thr Gln Pro Leu Thr His Asn Val Tyr Ser Asp Arg
455 460 465AGC CAT ATA ATG TTT AAC ATT GCT TAC GGT TTT AGG ATT TAC TAGCATTTT 1500Ser His Ile Met Phe Asn Ile Ala Tyr Gly Phe Arg Ile Tyr
470 475 480ATCCTTAATG GATATTTTTG ATTAGCCTTT TTAAAATATT GAAA 1544
(2) Sequence 38 data:
(i) sequence characteristics:
(A) length: 480 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 38: met Pro Phe Cys Ile Phe Ile Leu Ile Ser Leu Gly Val Arg Val Leu 151015 Glu Ile Lys Lys Tyr Phe Ser Tyr Ser Leu Phe Phe Leu Leu Phe Ser
20 25 30Ser Leu Phe Leu Ser Lys Leu Gln Ala Tyr Lys Phe Asn Met Ser Ile
35 40 45Val Gly Lys Val Ser Ser Tyr Thr Lys Phe Gly Phe Asn Asn Gln Arg
50 55 60Tyr Gln Pro Ser Lys Asp Ile Tyr Pro Thr Gly Ser Tyr Thr Ser Leu65 70 75 80Leu Gly Glu Leu Asn Leu Ser Met Gly Leu Tyr Lys Gly Leu Arg Ala
85 90 95Glu Val Gly Ala Met Met Ala Ala Leu Pro Tyr Asp Ser Thr Ala Tyr
100 105 110Gln Gly Asn Asn Ile Pro Asn GlyGln Pro Gly Ser Arg Thr Asp Pro
115 120 125Phe Gly Ala Gly Ile Phe Trp Gln Tyr Ile Gly Trp Tyr Ala Gly His
130 135 140Ser Gly Leu Gln Val Gln Lys Pro Arg Leu Ala Met Val His Asn Ala145 150 155 160Phe Leu Ser Tyr Asn Tyr Lys Lys Asp Lys Phe Ser Phe Gly Val Lys
165 170 175Gly Gly Arg Tyr Asp Ala Glu Glu Tyr Asp Trp Phe Thr Ser Tyr Thr
180 185 190Gln Gly Val Glu Gly Phe Val Lys Tyr Lys Asp Thr Arg Phe Arg Val
195 200 205Met Tyr Ser Asp Ala Arg Ala Ser Ala Ser Ser Asp Trp Phe Trp Tyr
210 215 220Phe Gly Arg Tyr Tyr Thr Ser Gly Lys Ala Leu Met Val Ala Asp Leu225 230 235 240Lys Tyr Glu Lys Asp Asn Leu Lys Ile Asn Pro Tyr Phe Tyr Ala Ile
245 250 255Phe Gln Arg Met Tyr Ala Pro Gly Ile Asn Ile Thr Tyr Asp Thr Asn
260 265 270Pro Asn Phe Asn Asn Lys Gly Phe Arg Phe Val Gly Thr Phe Val Gly
275 280 285Phe Phe Pro Ile Phe Ala Thr Pro Ala Asn Gln Asn Asp Ile Ile Leu
290 295 300Phe Gln Gln Val Pro Leu Gly Lys Ser Gly Gln Thr Tyr Phe Phe Arg305 310 315 320Thr Arg Phe Tyr Tyr Asn Lys Trp Gln Phe Gly Gly Ser Val Tyr Lys
325 330 335Asn Ile Gly Asn Ala Asn Gly Asp Ile Gly Ile Tyr Gly Asp Pro Leu
340 345 350Gly Tyr Asn Ile Trp Thr Asn Ser Ile Tyr Asp Ala Glu Ile Asn Asn
355 360 365Ile Val Gly Ala Asp Val Ile Asn Gly Phe Leu Tyr Val Gly Ser Gln
370 375 380Tyr Arg Gly Phe Ser Trp Lys Ile Leu Gly Arg Trp Thr Asp Ser Pro385 390 395 400Arg Ala Asp Glu Arg Ser Leu Ala Leu Phe Leu Ser Tyr Phe Ser Asn
405 410 415Lys Tyr Asn Ile Arg Met Asp Leu Lys Leu Glu Tyr Tyr Gly Asn Ile
420 425 430Thr Lys Lys Gly Tyr Cys Ile Gly Tyr Cys Gly Met Tyr Val Pro Val
435 440 445Asp Pro Asn Gly Pro Gly Thr Gln Pro Leu Thr His Asn Val Tyr Ser
450 455 460Asp Arg Ser His Ile Met Phe Asn Ile Ala Tyr Gly Phe Arg Ile Tyr465 470 475 480
(2) Sequence 39 data: (i) sequence characteristics:
(A) length: 658bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...605
(D) Other information: (xi) Description of the sequence: sequence 39: AATTTTAGGT TATTAGTTAC CATTTTATTA TTCTTAAGGA TGTGTTTATA ATG AGA 56
Met Arg
1ATT AAG GCT TAT TTT TTG CGT TTT ATC GCG CTG GTT TTG ATT GTT TTG 104Ile Lys Ala Tyr Phe Leu Arg Phe Ile Ala Leu Val Leu Ile Val Leu
5 10 15TTA GGT TTT AGT GCT TGT AAA AAT TCT CAA AAA TCT CAA GAT TCT CAA 152Leu Gly Phe Ser Ala Cys Lys Asn Ser Gln Lys Ser Gln Asp Ser Gln
20 25 30AAC AAT ACC CCC CAA CAA GAT AGC CCT AAA ACC TAC ACC GCT ATG GAT 200Asn Asn Thr Pro Gln Gln Asp Ser Pro Lys Thr Tyr Thr Ala Met Asp35 40 45 50TTG AAT AAC CAA GAA TAC ACC ATC ACA GGC GAT TTA GAT TCT CTC AAT 248Leu Asn Asn Gln Glu Tyr Thr Ile Thr Gly Asp Leu Asp Ser Leu Asn
55 60 65ATC AGC CCG GAT TCC AAC ACC CCT ACC CTA TTA GTT TTA AGC GCT TTA 296Ile Ser Pro Asp Ser Asn Thr Pro Thr Leu Leu Val Leu Ser Ala Leu
70 75 80GAT AAT TCT TTA AAA GAT TAC GCC CCC AGC TTT AAC ATC TTA AAA AAA 344Asp Asn Ser Leu Lys Asp Tyr Ala Pro Ser Phe Asn Ile Leu Lys Lys
85 90 95ACT TTT AAA GAT CGT TTG AGG GTG CTT ATT TTA CTC AAT AAA CCC TAT 392Thr Phe Lys Asp Arg Leu Arg Val Leu Ile Leu Leu Asn Lys Pro Tyr
100 105 110TCA AGC GAT GCA ATC AAA GAC TTT AGC GCG CAT TTT CAA GCT GAT TTG 440Ser Ser Asp Ala Ile Lys Asp Phe Ser Ala His Phe Gln Ala Asp Leu115 120 125 130ATG ATT TTA AAC CCT AAA GAT ACC GCT CTT TTT GAT CAT TTA AAG TAT 488Met Ile Leu Asn Pro Lys Asp Thr Ala Leu Phe Asp His Leu Lys Tyr
135 140 145GAC GCT TTA AAC CAT TCT TTT AAC ATG CTC TTA TAC CAC AAA CAC CAA 536Asp Ala Leu Asn His Ser Phe Asn Met Leu Leu Tyr His Lys His Gln
150 155 160TTG ATC AAA ATG TAT CAA GGG ATC GTG CCA ATA GAA ATG CTC CAA TTT 584Leu Ile Lys Met Tyr Gln Gly Ile Val Pro Ile Glu Met Leu Gln Phe
165 170 175GAT ATT TCC AAT TTA AAG GAT TAAAAAAAAC CATGTTTAAT TTTTTCAAAA AAAT 639Asp Ile Ser Asn Leu Lys Asp
180 185TGTCAATAAA ATTAAGGGT 658
(2) Sequence 40 data: (i) sequence characteristics:
(A) length: 185 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 40: met Arg Ile Lys Ala Tyr Phe Leu Arg Phe Ile Ala Leu Val Leu Ile 151015 Val Leu Leu Gly Phe Ser Ala Cys Lys Asn Ser Gln Lys Ser Gln Asp
20 25 30Ser Gln Asn Asn Thr Pro Gln Gln Asp Ser Pro Lys Thr Tyr Thr Ala
35 40 45Met Asp Leu Asn Asn Gln Glu Tyr Thr Ile Thr Gly Asp Leu Asp Ser
50 55 60Leu Asn Ile Ser Pro Asp Ser Asn Thr Pro Thr Leu Leu Val Leu Ser65 70 75 80Ala Leu Asp Asn Ser Leu Lys Asp Tyr Ala Pro Ser Phe Asn Ile Leu
85 90 95Lys Lys Thr Phe Lys Asp Arg Leu Arg Val Leu Ile Leu Leu Asn Lys
100 105 110Pro Tyr Ser Ser Asp Ala Ile Lys Asp Phe Ser Ala His Phe Gln Ala
115 120 125Asp Leu Met Ile Leu Asn Pro Lys Asp Thr Ala Leu Phe Asp His Leu
130 135 140Lys Tyr Asp Ala Leu Asn His Ser Phe Asn Met Leu Leu Tyr His Lys145 150 155 160His Gln Leu Ile Lys Met Tyr Gln Gly Ile Val Pro Ile Glu Met Leu
165 170 175Gln Phe Asp Ile Ser Asn Leu Lys Asp
180 185
(2) Data for sequence 41: (i) sequence characteristics:
(A) length: 460bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...407
(D) Other information: (xi) Description of the sequence: sequence 41: AATCCCTTCA AAAATGATAT AATAGACTTG ATGAACTCAT TTTAAGGAAA ATG CCC 56
Met Pro
1ATG CGT TTG CAC ACT GCC TTT TTT GGT ATT AAT TCA TTG CTT GTT GCC 104Met Arg Leu His Thr Ala Phe Phe Gly Ile Asn Ser Leu Leu Val Ala
5 10 15TCT CTT TTG ATA AGC GGT TGC AGT CTC TTT AAA AAG CGT AAC ACT AAC 152Ser Leu Leu Ile Ser Gly Cys Ser Leu Phe Lys Lys Arg Asn Thr Asn
20 25 30GCC CAG CTA ATC CCC CCT TCA GCT AAT GGC TTG CAA GCC CCC ATT TAT 200Ala Gln Leu Ile Pro Pro Ser Ala Asn Gly Leu Gln Ala Pro Ile Tyr35 40 45 50CCC CCA ACC AAT TTC ACC CCT AGA AAG AGC ATT CAG CCT CTC CCA AGC 248Pro Pro Thr Asn Phe Thr Pro Arg Lys Ser Ile Gln Pro Leu Pro Ser
55 60 65CCT CGC CTT GAG AAT AAC GAT CAG CCC GTC ATT AGT TCT AAC CCC ACT 296Pro Arg Leu Glu Asn Asn Asp Gln Pro Val Ile Ser Ser Asn Pro Thr
70 75 80AAC GCT ATC CCT AAC ACC CCC ATT CTC ACG CCT AAT AAT GTC ATT GAA 344Asn Ala Ile Pro Asn Thr Pro Ile Leu Thr Pro Asn Asn Val Ile Glu
85 90 95TTG AAC GCA TGG GCA TGG GCG TGG CTC CAG AAT CCA CCA TTT CAC CCT 392Leu Asn Ala Trp Ala Trp Ala Trp Leu Gln Asn Pro Pro Phe His Pro
100 105 110CTC AAG CCC TGG CTC TAGCCAAGCG GGCGGCTATC GTTGATGGCT ACCGCCAGTT G 448Leu Lys Pro Trp Leu115GGTGAAAAAATG 460
(2) Sequence 42 data:
(i) sequence characteristics:
(A) length: 119 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 42: met Pro Met Arg Leu His Thr Ala Phe Phe Gly Ile Asn Ser Leu Leu 151015 Val Ala Ser Leu Leu Ile Ser Gly Cys Ser Leu Phe Lys Lys Arg Asn
20 25 30Thr Asn Ala Gln Leu Ile Pro Pro Ser Ala Asn Gly Leu Gln Ala Pro
35 40 45Ile Tyr Pro Pro Thr Asn Phe Thr Pro Arg Lys Ser Ile Gln Pro Leu
50 55 60Pro Ser Pro Arg Leu Glu Asn Asn Asp Gln Pro Val Ile Ser Ser Asn65 70 75 80Pro Thr Asn Ala Ile Pro Asn Thr Pro Ile Leu Thr Pro Asn Asn Val
85 90 95Ile Glu Leu Asn Ala Trp Ala Trp Ala Trp Leu Gln Asn Pro Pro Phe
100 105 110His Pro Leu Lys Pro Trp Leu
115
(2) Sequence 43 data: (i) sequence characteristics:
(A) length: 1285bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...1232
(D) Other information: (xi) Description of the sequence: sequence 43: GTTGTGATTT TATTGTGTTT TCATATCAAT TTTCATATCA AGGAGTTTAA ATG AAA 56
Met Lys
1GAA ACA AGA CTT TTA AAA TTG AGA GCG TTG AGC TTA GCA TGT TTA ATG 104Glu Thr Arg Leu Leu Lys Leu Arg Ala Leu Ser Leu Ala Cys Leu Met
5 10 15GGA TTA GGC GTG AGT GGG TGC GCG TTT TTA GAT AAG CAA ATC TTA AAC 152Gly Leu Gly Val Ser Gly Cys Ala Phe Leu Asp Lys Gln Ile Leu Asn
20 25 30GAC CAT TTG ACT AAA GCT AAA AAT AAC CCA AAA TAC GAT TGC CAA AAA 200Asp His Leu Thr Lys Ala Lys Asn Asn Pro Lys Tyr Asp Cys Gln Lys35 40 45 50GAA ATG TGG TCT TTC CCT AAA AAA TAC GAT GGG ATA AAT CAG TGT TTA 248Glu Met Trp Ser Phe Pro Lys Lys Tyr Asp Gly Ile Asn Gln Cys Leu
55 60 65AAG GCT CAA GAA GAG CTT ATT GAA CCA ATC ATC ACT AAA AAG ATC GAT 296Lys Ala Gln Glu Glu Leu Ile Glu Pro Ile Ile Thr Lys Lys Ile Asp
70 75 80CAG TAT CAA TGC GAT GAT TTC ACT AAT GAA GGC TTA AAA GAT AAG TGT 344Gln Tyr Gln Cys Asp Asp Phe Thr Asn Glu Gly Leu Lys Asp Lys Cys
85 90 95TTC AAA AGA AAC GAT GCC TAC TTA AAC ACC CTT TTA ACG CCC ATC ATT 392Phe Lys Arg Asn Asp Ala Tyr Leu Asn Thr Leu Leu Thr Pro Ile Ile
100 105 110CAA AAA CAA GAG CGT CGT TTT AGC TGC TCT GAT TTC CAT AAC CCA GAG 440Gln Lys Gln Glu Arg Arg Phe Ser Cys Ser Asp Phe His Asn Pro Glu115 120 125 130CTA AAA GAA CAA TGC ATG GAT AAA ACT AAC GCT TAT GAA AAG CAA AAA 488Leu Lys Glu Gln Cys Met Asp Lys Thr Asn Ala Tyr Glu Lys Gln Lys
135 140 145GAC CGA CAA AAA AGA CTA ATT AAT CTC GTG CAA TTA GAA GCG TTT GAA 536Asp Arg Gln Lys Arg Leu Ile Asn Leu Val Gln Leu Glu Ala Phe Glu
150 155 160AAA GAA TAC GCG CAA TAT AAA CCA TAC ATT ATC CCT TAC TTC ACC AAA 584Lys Glu Tyr Ala Gln Tyr Lys Pro Tyr Ile Ile Pro Tyr Phe Thr Lys
165 170 175GAA TGC GTT AAA AAT GCG CCC CAT TTA GCC AAC AAG GAA AGA CTA TGC 632Glu Cys Val Lys Asn Ala Pro His Leu Ala Asn Lys Glu Arg Leu Cys
180 185 190CAA AAA GAA GTG CAT GAA AAA TTT GAC GAC CCT TAT TCT AGC TCT AAA 680Gln Lys Glu Val His Glu Lys Phe Asp Asp Pro Tyr Ser Ser Ser Lys195 200 205 210GAA TTG AGC GTT CAA TCG GCT ATT TCT TTT TGC ATT AAA AAA GTT GAT 728Glu Leu Ser Val Gln Ser Ala Ile Ser Phe Cys Ile Lys Lys Val Asp
215 220 225GCT AAA TTA GAA AAA GCC GCT CTT ATG AAT GGC GTT TAT ATA AGC CCT 776Ala Lys Leu Glu Lys Ala Ala Leu Met Asn Gly Val Tyr Ile Ser Pro
230 235 240TAT AAA AAA TCC ACC CAT TGC CAA AGA ACG CAT TTG GAA AAT AAG AGC 824Tyr Lys Lys Ser Thr His Cys Gln Arg Thr His Leu Glu Asn Lys Ser
245 250 255TTG AAA GAA ATC GCT TTA AAT ATG AAC CCT AAA TTA GAA AAG CAA AGC 872Leu Lys Glu Ile Ala Leu Asn Met Asn Pro Lys Leu Glu Lys Gln Ser
260 265 270CCT TTT ATT GAT GCG GAT AAA ATG GCT ATG CAA TCT GCG GGG TTA TTG 920Pro Phe Ile Asp Ala Asp Lys Met Ala Met Gln Ser Ala Gly Leu Leu275 280 285 290AGA AAG AAT AAA GGT GTC TTG ATT GCT TTT GCT ACA GAT ATT TGC ATG 968Arg Lys Asn Lys Gly Val Leu Ile Ala Phe Ala Thr Asp Ile Cys Met
295 300 305GAG CGT AAC GAA CAT AAA AAA GAA GAG TTT ATC AGC CTT AAA GAT AGT 1016Glu Arg Asn Glu His Lys Lys Glu Glu Phe Ile Ser Leu Lys Asp Ser
310 315 320TGC ACC CAA TCG CAA GCC AAA ATC TAT AAC AAC AAG GAG CGC TTT GAC 1064Cys Thr Gln Ser Gln Ala Lys Ile Tyr Asn Asn Lys Glu Arg Phe Asp
325330 335AAA TTC ATA CAA GAT TAC CAA AAA GAC TTA AAA ACT TGT CTT TTA GAC 1112Lys Phe Ile Gln Asp Tyr Gln Lys Asp Leu Lys Thr Cys Leu Leu Asp
340 345 350ACT TCT AAC ACT AAA GAA GAA GTG GAG CAA AAT TTT TCA CAA TGC CAA 1160Thr Ser Asn Thr Lys Glu Glu Val Glu Gln Asn Phe Ser Gln Cys Gln355 360 365 370AAA GAG CAA TTG AGA GAT GAT AAC AAA GGC TTG GGT TTC ACT TTA GAA 1208Lys Glu Gln Leu Arg Asp Asp Asn Lys Gly Leu Gly Phe Thr Leu Glu
375 380 385GAA TTG GTT AAA AAA TAC GCT AAG TAAAGTTATT TAATTTTATG GATGGTTTTA 1262Glu Leu Val Lys Lys Tyr Ala Lys
390AAAATCCATT CCATAGTTAT TGT 1285
(2) Sequence 44 data: (i) sequence characteristics:
(A) length: 394 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 44: met Lys Glu Thr Arg Leu Leu Lys Leu Arg Ala Leu Ser Leu Ala Cys 151015 Leu Met Gly Leu Gly Val Ser Gly Cys Ala Phe Leu Asp Lys Gln Ile
20 25 30Leu Asn Asp His Leu Thr Lys Ala Lys Asn Asn Pro Lys Tyr Asp Cys
35 40 45Gln Lys Glu Met Trp Ser Phe Pro Lys Lys Tyr Asp Gly Ile Asn Gln
50 55 60Cys Leu Lys Ala Gln Glu Glu Leu Ile Glu Pro Ile Ile Thr Lys Lys65 70 75 80Ile Asp Gln Tyr Gln Cys Asp Asp Phe Thr Asn Glu Gly Leu Lys Asp
85 90 95Lys Cys Phe Lys Arg Asn Asp Ala Tyr Leu Asn Thr Leu Leu Thr Pro
100 105 110Ile Ile Gln Lys Gln Glu Arg Arg Phe Ser Cys Ser Asp Phe His Asn
115 120 125Pro Glu Leu Lys Glu Gln Cys Met Asp Lys Thr Asn Ala Tyr Glu Lys
130 135 140Gln Lys Asp Arg Gln Lys Arg Leu Ile Asn Leu Val Gln Leu Glu Ala145 150 155 160Phe Glu Lys Glu Tyr Ala Gln Tyr Lys Pro Tyr Ile Ile Pro Tyr Phe
165 170 175Thr Lys Glu Cys Val Lys Asn Ala Pro His Leu Ala Asn Lys Glu Arg
180 185 190Leu Cys Gln Lys Glu Val His Glu Lys Phe Asp Asp Pro Tyr Ser Ser
195 200 205Ser Lys Glu Leu Ser Val Gln Ser Ala Ile Ser Phe Cys Ile Lys Lys
210 215 220Val Asp Ala Lys Leu Glu Lys Ala Ala Leu Met Asn Gly Val Tyr Ile225 230 235 240Ser Pro Tyr Lys Lys Ser Thr His Cys Gln Arg Thr His Leu Glu Asn
245 250 255Lys Ser Leu Lys Glu Ile Ala Leu Asn Met Asn Pro Lys Leu Glu Lys
260 265 270Gln Ser Pro Phe Ile Asp Ala Asp Lys Met Ala Met Gln Ser Ala Gly
275 280 285Leu Leu Arg Lys Asn Lys Gly Val Leu Ile Ala Phe Ala Thr Asp Ile
290 295 300Cys Met Glu Arg Asn Glu His Lys Lys Glu Glu Phe Ile Ser Leu Lys305 310315 320Asp Ser Cys Thr Gln Ser Gln Ala Lys Ile Tyr Asn Asn Lys Glu Arg
325 330 335Phe Asp Lys Phe Ile Gln Asp Tyr Gln Lys Asp Leu Lys Thr Cys Leu
340 345 350Leu Asp Thr Ser Asn Thr Lys Glu Glu Val Glu Gln Asn Phe Ser Gln
355 360 365Cys Gln Lys Glu Gln Leu Arg Asp Asp Asn Lys Gly Leu Gly Phe Thr
370 375 380Leu Glu Glu Leu Val Lys Lys Tyr Ala Lys385 390
(2) Sequence 45 data:
(i) sequence characteristics:
(A) length: 835bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic RNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 84...704
(D) Other information:
(xi) Description of the sequence: sequence 45: TTGATCATTC TTATTTCGCA CAACCCAAGC ACGCTAAAAT TAGCCACTAA GCATGTGAAA 60TTAGAGCATG GGCGTTTGAC AGA ATG CTA AGG GTT TTA AGC GTT GGT GTT GCT 113
Met Leu Arg Val Leu Ser Val Gly Val Ala
1 5 10TTT ATT TTA CTA GGG TGT CAG TTT TTC AAC AAA ACG ACG CTG CAT TTA 161Phe Ile Leu Leu Gly Cys Gln Phe Phe Asn Lys Thr Thr Leu His Leu
15 20 25AAA TAT AAA GATTAC CCC AAA AAT AGC GCT TTA AAA ACC GCT TTC ACT 209Lys Tyr Lys Asp Tyr Pro Lys Asn Ser Ala Leu Lys Thr Ala Phe Thr
30 35 40TTA ACC CCC CCT AAA ATC TTT TTT AAC GCC CGT TTT GTG CCG CCC TTT 257Leu Thr Pro Pro Lys Ile Phe Phe Asn Ala Arg Phe Val Pro Pro Phe
45 50 55TAC CAA AAA GAA TTT AAA AAA GCG ATC ACC CAA CAA ATC GCT TAT TTT 305Tyr Gln Lys Glu Phe Lys Lys Ala Ile Thr Gln Gln Ile Ala Tyr Phe
60 65 70TTA AAA GAT AAA AGT GCT TTT ATT CTC AAT GTT TCA GGC AAT GTT TTT 353Leu Lys Asp Lys Ser Ala Phe Ile Leu Asn Val Ser Gly Asn Val Phe75 80 85 90TTT TCT TTT GAA GAG AAT CCT AAA GAT TTA AAA GCC ATT AAA GAA AGG 401Phe Ser Phe Glu Glu Asn Pro Lys Asp Leu Lys Ala Ile Lys Glu Arg
95 100 105CTT AAA AAG ACG ATT GAG CCT AAC GCT GAC CCA AAA GCC GTC ATG CGT 449Leu Lys Lys Thr Ile Glu Pro Asn Ala Asp Pro Lys Ala Val Met Arg
110 115 120TTT TTA AAC CTT CAA GCG AGC TTG ATT TTA GAA TGC GTC CCG CAA ACC 497Phe Leu Asn Leu Gln Ala Ser Leu Ile Leu Glu Cys Val Pro Gln Thr
125 130 135ACT TGC CCG TTT GAC ACC CTT TTA ATC CCC ACC GCT TTC AGC GTG CCT 545Thr Cys Pro Phe Asp Thr Leu Leu Ile Pro Thr Ala Phe Ser Val Pro
140 145 150GTT TAT TAC GCT AAT CGT TTG GGC GAT AAC CCC TCT CTT TTT TCC CAA 593Val Tyr Tyr Ala Asn Arg Leu Gly Asp Asn Pro Ser Leu Phe Ser Gln155 160 165 170GAG GAT AAA ACC TAT CAT AAC GCT TTG ATC AAA GCC CTT AAT AAG GCT 641Glu Asp Lys Thr Tyr His Asn Ala Leu Ile Lys AlaLeu Asn Lys Ala
175 180 185TAC TAT TCT CTT ATG GAG GGT TTA GAA AAG CGT TTG AAC GCT ATA AAA 689Tyr Tyr Ser Leu Met Glu Gly Leu Glu Lys Arg Leu Asn Ala Ile Lys
190 195 200AAT GCA GAG TGG CTT TAAGGCATGA AAAAGATTGC ATTTTTTATT TTTGTCATTT T 745Asn Ala Glu Trp Leu
205GTTTTCGGTA GGGATTTATT TAATTTGGCA TGTTTTATTG GAAAAAGCCC TAGAATTGAA 805ATTAGCAACC TCAGCTAATG ATTTGCTTTT 835
(2) Sequence 46 data: (i) sequence characteristics:
(A) length: 207 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 46: met Leu Arg Val Leu Ser Val Gly Val Ala Phe Ile Leu Leu Gly Cys 151015 Gln Phe Phe Asn Lys Thr Thr Leu His Leu Lys Tyr Lys Asp Tyr Pro
20 25 30Lys Asn Ser Ala Leu Lys Thr Ala Phe Thr Leu Thr Pro Pro Lys Ile
35 40 45Phe Phe Asn Ala Arg Phe Val Pro Pro Phe Tyr Gln Lys Glu Phe Lys
50 55 60Lys Ala Ile Thr Gln Gln Ile Ala Tyr Phe Leu Lys Asp Lys Ser Ala65 70 75 80Phe Ile Leu Asn Val Ser Gly Asn Val Phe Phe Ser Phe Glu Glu Asn
85 90 95Pro Lys Asp Leu Lys Ala Ile Lys Glu Arg Leu Lys Lys Thr Ile Glu
100 105 110Pro Asn Ala Asp Pro Lys Ala Val Met Arg Phe Leu Asn LeuGln Ala
115 120 125Ser Leu Ile Leu Glu Cys Val Pro Gln Thr Thr Cys Pro Phe Asp Thr
130 135 140Leu Leu Ile Pro Thr Ala Phe Ser Val Pro Val Tyr Tyr Ala Asn Arg145 150 155 160Leu Gly Asp Asn Pro Ser Leu Phe Ser Gln Glu Asp Lys Thr Tyr His
165 170 175Asn Ala Leu Ile Lys Ala Leu Asn Lys Ala Tyr Tyr Ser Leu Met Glu
180 185 190Gly Leu Glu Lys Arg Leu Asn Ala Ile Lys Asn Ala Glu Trp Leu
195 200 205
(2) Sequence 47 data: (i) sequence characteristics:
(A) length: 763bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 51...710
(D) Other information: (xi) Description of the sequence: sequence 47: AAAAAATAAC CATGAGTTAT TCAAAAATTT AACTTTATAA GACAGGTGGC ATG CGT 56
Met Arg
1TTA AAA CAT TTT AAA ACT TTC CTT TTT ATC ACA ATG GCA ATC ATT GTA 104Leu Lys His Phe Lys Thr Phe Leu Phe Ile Thr Met Ala Ile Ile Val
5 10 15ATA GGT ACC GGT TGC GCG AAC AAA AAG AAA AAA AAA GAC GAA TAC AAC 152Ile Gly Thr Gly Cys Ala Asn Lys Lys Lys Lys Lys Asp Glu Tyr Asn
20 25 30AAA CCG GCG ATC TTT TGG TAT CAA GGG ATT TTG AGA GAA ATC CTT TTT 200Lys Pro Ala Ile Phe Trp Tyr Gln Gly Ile Leu Arg Glu Ile Leu Phe35 40 45 50GCT AAT TTA GAA ACA GCG GAC AAT TAC TAT TCT TCT TTA CAA AGC GAA 248Ala Asn Leu Glu Thr Ala Asp Asn Tyr Tyr Ser Ser Leu Gln Ser Glu
55 60 65CAC ATC AAT TCC CCC CTT GTC CCA GAA GCG ATG CTA GCT TTA GGG CAA 296His Ile Asn Ser Pro Leu Val Pro Glu Ala Met Leu Ala Leu Gly Gln
70 75 80GCG CAC ATG AAA AAG AAA GAG TAT GTT TTA GCG TCT TTT TAC TTT GAT 344Ala His Met Lys Lys Lys Glu Tyr Val Leu Ala Ser Phe Tyr Phe Asp
85 90 95GAA TAC ATC AAG CGC TTT GGG ACT AAG GAC AAT GTG GAT TAT TTG ACT 392Glu Tyr Ile Lys Arg Phe Gly Thr Lys Asp Asn Val Asp Tyr Leu Thr
100 105 110TTT TTA AAA TTG CAA TCG CAT TAT TAC GCT TTC AAA AAC CAT TCT AAA 440Phe Leu Lys Leu Gln Ser His Tyr Tyr Ala Phe Lys Asn His Ser Lys115 120 125 130GAC CAG GAA TTT ATC TCT AAT TCT ATT GTG AGT TTA GGC GAA TTT ATA 488Asp Gln Glu Phe Ile Ser Asn Ser Ile Val Ser Leu Gly Glu Phe Ile
135 140 145GAA AAA TAC CCT AAC AGC CGT TAC CGC CCC TAT GTA GAA TAC ATG CAA 536Glu Lys Tyr Pro Asn Ser Arg Tyr Arg Pro Tyr Val Glu Tyr Met Gln
150 155 160ATC AAA TTC ATT TTA GGG CAA AAT GAG CTC AAT CGC GCG ATC GCG AAT 584Ile Lys Phe Ile Leu Gly Gln Asn Glu Leu Asn Arg Ala Ile Ala Asn
165 170 175GTC TAT AAAAAA CGC CAC AAG CCT GAG GGC GTG AAA CGC TAT TTA GAA 632Val Tyr Lys Lys Arg His Lys Pro Glu Gly Val Lys Arg Tyr Leu Glu
180 185 190AGG ATA GAT GAG ACT TTA GAA AAA GAG ACT AAA CCC AAA CCA TCG CAC 680Arg Ile Asp Glu Thr Leu Glu Lys Glu Thr Lys Pro Lys Pro Ser His195 200 205 210ATG CCT TGG TAT GTG TTA ATT TTT GAT TGG TAGGATATTT CAAAACCATA CAC 733Met Pro Trp Tyr Val Leu Ile Phe Asp Trp
215 220ATTATAACAG AGAGATGAAA AATGACTGAA 763
(2) Data for sequence 48:
(i) sequence characteristics:
(A) length: 220 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 48: met Arg Leu Lys His Phe Lys Thr Phe Leu Phe Ile Thr Met Ala Ile 151015 Ile Val Ile Gly Thr Gly Cys Ala Asn Lys Lys Lys Lys Lys Asp Glu
20 25 30Tyr Asn Lys Pro Ala Ile Phe Trp Tyr Gln Gly Ile Leu Arg Glu Ile
35 40 45Leu Phe Ala Asn Leu Glu Thr Ala Asp Asn Tyr Tyr Ser Ser Leu Gln
50 55 60Ser Glu His Ile Asn Ser Pro Leu Val Pro Glu Ala Met Leu Ala Leu65 70 75 80Gly Gln Ala His Met Lys Lys Lys Glu Tyr Val Leu Ala Ser Phe Tyr
85 9095Phe Asp Glu Tyr Ile Lys Arg Phe Gly Thr Lys Asp Asn Val Asp Tyr
100 105 110Leu Thr Phe Leu Lys Leu Gln Ser His Tyr Tyr Ala Phe Lys Asn His
115 120 125Ser Lys Asp Gln Glu Phe Ile Ser Asn Ser Ile Val Ser Leu Gly Glu
130 135 140Phe Ile Glu Lys Tyr Pro Asn Ser Arg Tyr Arg Pro Tyr Val Glu Tyr145 150 155 160Met Gln Ile Lys Phe Ile Leu Gly Gln Asn Glu Leu Asn Arg Ala Ile
165 170 175Ala Asn Val Tyr Lys Lys Arg His Lys Pro Glu Gly Val Lys Arg Tyr
180 185 190Leu Glu Arg Ile Asp Glu Thr Leu Glu Lys Glu Thr Lys Pro Lys Pro
195 200 205Ser His Met Pro Trp Tyr Val Leu Ile Phe Asp Trp
210 215 220
(2) Sequence 49 data:
(i) sequence characteristics:
(A) length: 801bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 75...749
(D) Other information:
(xi) Description of the sequence: sequence 49: GAAAAAGGCT CTGCTTTGAT AGATAAATTT GACGCTAACC CCTATAAAAC GATTTTTGGA 60GAAAGGAAAT AATC ATG AGA GCT ACG GCG ATA AAA ATC TTT TCA CTC TCA 110
Met Arg Ala Thr Ala Ile Lys Ile Phe Ser Leu Ser
1 5 10TCA GCA TTA GCC CTA TTG CTT CAT GGT TGC TTG AGC ATC AAT TTA AAA 158Ser Ala Leu Ala Leu Leu Leu His Gly Cys Leu Ser Ile Asn Leu Lys
15 20 25CAA ATG CTA CCA GAG ATC AGA ACT TAC GAT TTG AAT GCG AGT TCT TTT 206Gln Met Leu Pro Glu Ile Arg Thr Tyr Asp Leu Asn Ala Ser Ser Phe
30 35 40GAA ATC ACG CAA TGC GCT AAA CCT TTG ACT GAA GTG AGG CTC ATT AGT 254Glu Ile Thr Gln Cys Ala Lys Pro Leu Thr Glu Val Arg Leu Ile Ser45 50 55 60ATT TTG AGC GCG GAT TTA TTC AAC ACT AAA GAG ATC GTT TTT AAA GCC 302Ile Leu Ser Ala Asp Leu Phe Asn Thr Lys Glu Ile Val Phe Lys Ala
65 70 75AAA GAC GGG CAG ATC ACG CAT GGG AAG CAC CAA AAA TGG ATA GAC TTG 350Lys Asp Gly Gln Ile Thr His Gly Lys His Gln Lys Trp Ile Asp Leu
80 85 90CCT CGC AAC ATG CTA AAA ACC ATG TTC ATG CAA GAA GCG CAA AAA GCA 398Pro Arg Asn Met Leu Lys Thr Met Phe Met Gln Glu Ala Gln Lys Ala
95 100 105TGC TTA GGC GTG GCT TTG CCT CCT TAT GGC GCG GGT GCA CCC ACT TAT 446Cys Leu Gly Val Ala Leu Pro Pro Tyr Gly Ala Gly Ala Pro Thr Tyr
110 115 120GCG GTT CGT TTT ACG ATT TTA TCG TTT TCT CTT TTA GAA AAA GAA AAT 494Ala Val Arg Phe Thr Ile Leu Ser Phe Ser Leu Leu Glu Lys Glu Asn125 130 135 140TCT ACC TAT AGG GCG GAA TTT GCA CTA GGC TAT GAC ATT AGC GTG AAA 542Ser Thr Tyr Arg Ala Glu Phe Ala Leu Gly Tyr Asp Ile Ser Val Lys
145 150 155GGC GAT TCG CAT TCT GGG GTG ATC ATT AAG CAT GAA AAT ATT TCT AGC 590Gly Asp Ser His Ser Gly Val Ile Ile Lys His Glu Asn Ile Ser Ser
160 165 170TTG GAA AAT AAA ACG ACC AAA ACG AGT AAA AAT GGC AAT CAA GAT TTT 638Leu Glu Asn Lys Thr Thr Lys Thr Ser Lys Asn Gly Asn Gln Asp Phe
175 180 185CAA GAA AGC GCG ATA CAA TCT CTC CAA CAT GTA AGC GTG CAA GCG ATT 686Gln Glu Ser Ala Ile Gln Ser Leu Gln His Val Ser Val Gln Ala Ile
190 195 200CAA GAA GCG GTT TCT TTG ATT AAA AAA GCC ATT GAA GCG CAA AGC GTA 734Gln Glu Ala Val Ser Leu Ile Lys Lys Ala Ile Glu Ala Gln Ser Val205 210 215 220AGC CCG TTA AAA AAA TAAAAAATAA GGAGGAATTG TTTGATTTTA CGATTGGCTG G 790Ser Pro Leu Lys Lys
225AGCAAGCGTT T 801
(2) Sequence 50 data: (i) sequence characteristics:
(A) length: 225 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 50: met Arg Ala Thr Ala Ile Lys Ile Phe Ser Leu Ser Ser Ala Leu Ala 151015 Leu Leu Leu His Gly Cys Leu Ser Ile Asn Leu Lys Gln Met Leu Pro
20 25 30Glu Ile Arg Thr Tyr Asp Leu Asn Ala Ser Ser Phe Glu Ile Thr Gln
35 40 45Cys Ala Lys Pro Leu Thr Glu Val Arg Leu Ile Ser Ile Leu Ser Ala
50 55 60Asp Leu Phe Asn Thr Lys Glu Ile Val Phe Lys Ala Lys Asp Gly Gln65 70 75 80Ile Thr His Gly Lys His Gln Lys Trp Ile Asp Leu Pro Arg Asn Met
85 90 95Leu Lys Thr Met Phe Met Gln Glu Ala Gln Lys Ala Cys Leu Gly Val
100 105 110Ala Leu Pro Pro Tyr Gly Ala Gly Ala Pro Thr Tyr Ala Val Arg Phe
115 120 125Thr Ile Leu Ser Phe Ser Leu Leu Glu Lys Glu Asn Ser Thr Tyr Arg
130 135 140Ala Glu Phe Ala Leu Gly Tyr Asp Ile Ser Val Lys Gly Asp Ser His145 150 155 160Ser Gly Val Ile Ile Lys His Glu Asn Ile Ser Ser Leu Glu Asn Lys
165 170 175Thr Thr Lys Thr Ser Lys Asn Gly Asn Gln Asp Phe Gln Glu Ser Ala
180 185 190Ile Gln Ser Leu Gln His Val Ser Val Gln Ala Ile Gln Glu Ala Val
195 200 205Ser Leu Ile Lys Lys Ala Ile Glu Ala Gln Ser Val Ser Pro Leu Lys
210 215 220Lys225
(2) Sequence 51 data:
(i) sequence characteristics:
(A) length: 448bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...395
(D) Other information:
(xi) Description of the sequence: sequence 51: TTTTATGATA AGATAGTCAA ATTATACATT GACTTAAGGA AATTTAATTG ATG AAA 56
Met Lys
1TCT AAA ATC ACT CAT TTT ATC GCT ATC TCT TTT GTT TTA AGC CTG TTT 104Ser Lys Ile Thr His Phe Ile Ala Ile Ser Phe Val Leu Ser Leu Phe
5 10 15
AGC GCA TGC AAA GAC GAG CCT AAA AAA TCG TCT CAA TCG CAC CAA AAC 152Ser Ala Cys Lys Asp Glu Pro Lys Lys Ser Ser Gln Ser His Gln Asn
20 25 30AAC ACT AAA ATC ACT AAA AAC AAT CCA ATC AAT CAA GCG AAT AAT GAT 200Asn Thr Lys Ile Thr Lys Asn Asn Pro Ile Asn Gln Ala Asn Asn Asp35 40 45 50ATA AGA AAA ATT GAG CAT GAA GAA GAA GAT GAA AAA GCC ACC AAA GAA 248Ile Arg Lys Ile Glu His Glu Glu Glu Asp Glu Lys Ala Thr Lys Glu
55 60 65GTG AAC GAT TTG ATC AAT AAC GAA AAT AAA ATT GAT GAA ATC AAT AAT 296Val Asn Asp Leu Ile Asn Asn Glu Asn Lys Ile Asp Glu Ile Asn Asn
70 75 80GAA GAA AAC GCT GAT CCT TCG CAA AAA AGA ACG AAC AAC GTT TTG CAA 344Glu Glu Asn Ala Asp Pro Ser Gln Lys Arg Thr Asn Asn Val Leu Gln
85 90 95CGA GCC ACT AAC CAC CAA GAC AAT CTC AAT TCC CCA CTC AAC AGG AAG 392Arg Ala Thr Asn His Gln Asp Asn Leu Asn Ser Pro Leu Asn Arg Lys
100105 110TAT TAAAGTGTGA AACTTTTTTC AAAGGATTTA TTTAAAAAAG TAACCCCTTT ATT 448Tyr115
(2) Sequence 52 data:
(i) sequence characteristics:
(A) length: 115 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 52: met Lys Ser Lys Ile Thr His Phe Ile Ala Ile Ser Phe Val Leu Ser 151015 Leu Phe Ser Ala Cys Lys Asp Glu Pro Lys Lys Ser Ser Gln Ser His
20 25 30Gln Asn Asn Thr Lys Ile Thr Lys Asn Asn Pro Ile Asn Gln Ala Asn
35 40 45Asn Asp Ile Arg Lys Ile Glu His Glu Glu Glu Asp Glu Lys Ala Thr
50 55 60Lys Glu Val Asn Asp Leu Ile Asn Asn Glu Asn Lys Ile Asp Glu Ile65 70 75 80Asn Asn Glu Glu Asn Ala Asp Pro Ser Gln Lys Arg Thr Asn Asn Val
85 90 95Leu Gln Arg Ala Thr Asn His Gln Asp Asn Leu Asn Ser Pro Leu Asn
100 105 110Arg Lys Tyr
115
(2) Sequence 53 data:
(i) sequence characteristics:
(A) length: 1121bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 121...1065
(D) Other information:
(xi) Description of the sequence: sequence 53: CTATCAAGTC AGTATTTCCA ATATCCAATT AGCCAATGAT CTCAAAGATT CTAATATTTT 60TATCCACCAG CGTTTAATCA TCCCCACCAA CAAAAAATTA CTCGCTACAA GGGAATTTTA 120 ATG GGT TTG GCG TTG GAA AAA GTT TGT TTT TTA GGC GTT ATT TTT TTG 168 Met Gly Leu Ala Leu Glu Lys Val Cys Phe Leu Gly Val Ile Phe Leu 151015 ATT AGC GCT TGC ACG GTT AAA AAA GAG GGG GTA AAG AAT TTG TCT TAC 216Ile Ser Ala Cys Thr Val Lys Lys Glu Gly Val Lys Asn Leu Ser Tyr
20 25 30AAG CAT GAA AGC TTG CGC GCT TAT GAA AAC GCT AAA GAT TAT GAT CCG 264Lys His Glu Ser Leu Arg Ala Tyr Glu Asn Ala Lys Asp Tyr Asp Pro
35 40 45ACA ACC AAA AAA GCC GCC TAT AAA CGC AAT TTT TTT GAA CGC CAT TTC 312Thr Thr Lys Lys Ala Ala Tyr Lys Arg Asn Phe Phe Glu Arg His Phe
50 55 60AAA CGC TAC TCC GAT TCG CAA GAT AGC AAC ACA AAA GAT CAG CCA CTA 360Lys Arg Tyr Ser Asp Ser Gln Asp Ser Asn Thr Lys Asp Gln Pro Leu65 70 75 80GAT AAC GGC ATG CGC GAT TCT AGC TCG ATC CAA AGA GCC ACC ATG CGC 408Asp Asn Gly Met Arg Asp Ser Ser Ser Ile Gln Arg Ala Thr Met Arg
85 90 95CCT TAT CAA GTG GGG GGC AAG TGG TAT TAC CCC ACT AAA GTG GAT TTA 456Pro Tyr Gln Val Gly Gly Lys Trp Tyr Tyr Pro Thr Lys Val Asp Leu
100 105 110GGC GAA AAA TTT GAT GGC GTT GCG AGT TGG TAT GGC CCT AAC TTC CAT 504Gly Glu Lys Phe Asp Gly Val Ala Ser Trp Tyr Gly Pro Asn Phe His
115 120 125GCC AAA AAA ACC AGT AAT GGG GAA ATT TAT AAC ATG TAT GCC CAC ACC 552Ala Lys Lys Thr Ser Asn Gly Glu Ile Tyr Asn Met Tyr Ala His Thr
130 135 140GCC GCG CAC AAA ACT TTA CCC ATG AAC ACC GTG GTG AAA GTC ATC AAT 600Ala Ala His Lys Thr Leu Pro Met Asn Thr Val Val Lys Val Ile Asn145 150 155 160GTT GAT AAT AAC TTA AGC ACC ATT GTG CGC ATC AAC GAT AGA GGG CCT 648Val Asp Asn Asn Leu Ser Thr Ile Val Arg Ile Asn Asp Arg Gly Pro
165 170 175TTT GTG AGC GAT CGC ATC ATT GAT TTG TCT AAT GCG GCC GCT AGG GAT 696Phe Val Ser Asp Arg Ile Ile Asp Leu Ser Asn Ala Ala Ala Arg Asp
180 185 190ATT GAC ATG GTT AAA AAA GGC ACA GCC AGC GTG CGT CTC ATT GTT TTG 744Ile Asp Met Val Lys Lys Gly Thr Ala Ser Val Arg Leu Ile Val Leu
195 200 205GGC TTT GGT GGG GTT ATC TCC ACG CAA TAC GAA CAA TCC TTT AAC GCC 792Gly Phe Gly Gly Val Ile Ser Thr Gln Tyr Glu Gln Ser Phe Asn Ala
210 215 220AGC TCT TCA AAG ATC TTG CAC AAG GAA TTT AAA GTC GGC GAG AGC GAA 840Ser Ser Ser Lys Ile Leu His Lys Glu Phe Lys Val Gly Glu Ser Glu225 230 235 240AAA AGC GTG AGC GGA GGG AAA TTT TCT TTG CAA ATG GGG GCT TTT AGA 888Lys Ser Val Ser Gly Gly Lys Phe Ser Leu Gln Met Gly Ala Phe Arg
245 250 255AAC CAA ATA GGT GCT CAA ACT TTA GCG GAT AAA TTG CAA GCA GAA AAT 936Asn Gln Ile Gly Ala Gln Thr Leu Ala Asp Lys Leu Gln Ala Glu Asn
260 265 270CCA AAT TAC AGC GTC AAG GTT GCT TTT AAA GAC GAT TTG TAT AAA GTT 984Pro Asn Tyr Ser Val Lys Val Ala Phe Lys Asp Asp Leu Tyr Lys Val
275 280 285TTA GTT CAA GGG TTT CAA AGC GAA GAA GAG GCT AGG GAT TTT ATG AAA 1032Leu Val Gln Gly Phe Gln Ser Glu Glu Glu Ala Arg Asp Phe Met Lys
290 295 300AAA TAC AAC CAG AAT GCG GTT TTA ACG AGA GAA TGATTAAGTT ATTGCTTTTA 1085Lys Tyr Asn Gln Asn Ala Val Leu Thr Arg Glu305 310 315GATGTGGATG GCACGCTCAC AGACGGATCG TTGTAT 1121
(2) Sequence 54 data:
(i) sequence characteristics:
(A) length: 315 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 54: met Gly Leu Ala Leu Glu Lys Val Cys Phe Leu Gly Val Ile Phe Leu 151015 Ile Ser Ala Cys Thr Val Lys Lys Glu Gly Val Lys Asn Leu Ser Tyr
20 25 30Lys His Glu Ser Leu Arg Ala Tyr Glu Asn Ala Lys Asp Tyr Asp Pro
35 40 45Thr Thr Lys Lys Ala Ala Tyr Lys Arg Asn Phe Phe Glu Arg His Phe
50 55 60Lys Arg Tyr Ser Asp Ser Gln Asp Ser Asn Thr Lys Asp Gln Pro Leu65 70 75 80Asp Asn Gly Met Arg Asp Ser Ser Ser Ile Gln Arg Ala Thr Met Arg
85 90 95Pro Tyr Gln Val Gly Gly Lys Trp Tyr Tyr Pro Thr Lys Val Asp Leu
100 105 110Gly Glu Lys Phe Asp Gly Val Ala Ser Trp Tyr Gly Pro Asn Phe His
115 120 125Ala Lys Lys Thr Ser Asn Gly Glu Ile Tyr Asn Met Tyr Ala His Thr
130 135 140Ala Ala His Lys Thr Leu Pro Met Asn Thr Val Val Lys Val Ile Asn145 150 155 160Val Asp Asn Asn Leu Ser Thr Ile Val Arg Ile Asn Asp Arg Gly Pro
165 170 175Phe Val Ser Asp Arg Ile Ile Asp Leu Ser Asn Ala Ala Ala Arg Asp
180 185 190Ile Asp Met Val Lys Lys Gly Thr Ala Ser Val Arg Leu Ile Val Leu
195 200 205Gly Phe Gly Gly Val Ile Ser Thr Gln Tyr Glu Gln Ser Phe Asn Ala
210 215 220Ser Ser Ser Lys Ile Leu His Lys Glu Phe Lys Val Gly Glu Ser Glu225 230 235 240Lys Ser Val Ser Gly Gly Lys Phe Ser Leu Gln Met Gly Ala Phe Arg
245 250 255Asn Gln Ile Gly Ala Gln Thr Leu Ala Asp Lys Leu Gln Ala Glu Asn
260 265 270Pro Asn Tyr Ser Val Lys Val Ala Phe Lys Asp Asp Leu Tyr Lys Val
275 280 285Leu Val Gln Gly Phe Gln Ser Glu Glu Glu Ala Arg Asp Phe Met Lys
290 295 300Lys Tyr Asn Gln Asn Ala Val Leu Thr Arg Glu305 310315
(2) Sequence 55 data:
(i) sequence characteristics:
(A) length: 811bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...761
(D) Other information:
(xi) Description of the sequence: sequence 55: TATAATAAGG AAATTCTAAA CGAAAATTAA ACTGAATGAA AGGAGTTTGA ATG AAA 56
Met Lys
1AAA ATC GTT TTA GTA GCG ATA GCC TTA TTG ATG AGC GCT TGC GCG AGC 104Lys Ile Val Leu Val Ala Ile Ala Leu Leu Met Ser Ala Cys Ala Ser
5 10 15TAT AAG ATC ACG CCT GAA CAT GTT ACT TCC TAT AAT AAT GGG ATT CAA 152Tyr Lys Ile Thr Pro Glu His Val Thr Ser Tyr Asn Asn Gly Ile Gln
20 25 30GTG ATG ACT TCC ACG CAA GCC AAA TCT AAA GTC CAG CTA GAA ATC GCT 200Val Met Thr Ser Thr Gln Ala Lys Ser Lys Val Gln Leu Glu Ile Ala35 40 45 50CAA AGC AAG TTG AAA GGC TTG AAC GAG TCC CCC TTA GTG CTG TAT GTA 248Gln Ser Lys Leu Lys Gly Leu Asn Glu Ser Pro Leu Val Leu Tyr Val
55 60 65GCG GCG CAA GTT ATA GAG GGA AGT CCT GTG GTG TTT AGC CGT AAA GCC 296Ala Ala Gln Val Ile Glu Gly Ser Pro Val Val Phe Ser Arg Lys Ala
70 75 80ATT TCA GTG TCT ATC AAC CAA ACG AAT TTA CCG GTC TTA AGC CTG AGA 344Ile Ser Val Ser Ile Asn Gln Thr Asn Leu Pro Val Leu Ser Leu Arg
85 90 95CAG GTG ATG AAA TCC AGT TTT GAT TTT GAG GGT ATT TTA CAA AGT TTT 392Gln Val Met Lys Ser Ser Phe Asp Phe Glu Gly Ile Leu Gln Ser Phe
100 105 110AAT ATC GCC GTG CCG ACC ACC CCT ATT GAT AAT GTC AAT ATG ATC ACC 440Asn Ile Ala Val Pro Thr Thr Pro Ile Asp Asn Val Asn Met Ile Thr115 120 125 130CCG CCT ATG TTT TAT TAC GGG CAA GGG GGA TTT TTA GCT TAT AAC GGC 488Pro Pro Met Phe Tyr Tyr Gly Gln Gly Gly Phe Leu Ala Tyr Asn Gly
135 140 145ATG ATG TAT GGG GGA ATG GGC ATG TAT GGG CCA GGC TTT GGC ATG ATG 536Met Met Tyr Gly Gly Met Gly Met Tyr Gly Pro Gly Phe Gly Met Met
150 155 160ATG ATG GAT GAT GTA GAA GAG CAA GAA GTC ATG CAA GAA AGC CGC CAA 584Met Met Asp Asp Val Glu Glu Gln Glu Val Met Gln Glu Ser Arg Gln
165 170 175GCT TTA AAA ATC CTA GCG ATC AAT TAC CTT AAA AAC AAC ACC CTT AAT 632Ala Leu Lys Ile Leu Ala Ile Asn Tyr Leu Lys Asn Asn Thr Leu Asn
180 185 190GTT GAG AGT AAG GCT AAG GGA GGG TTT GTG GTG GTG GAT ACC AAA AAC 680Val Glu Ser Lys Ala Lys Gly Gly Phe Val Val Val Asp Thr Lys Asn195 200 205 210CTT AAA ACC CCG GGT GTG GTG GTG GTT AAA GTC TTT TTA GAA GAT GAA 728Leu Lys Thr Pro Gly Val Val Val Val Lys Val Phe Leu Glu Asp Glu
215 220 225ATC CAC ACC TTT AAA ATT GATATT TCT AAG ATG TAATCGCCCC CTTTAATAAA 781Ile His Thr Phe Lys Ile Asp Ile Ser Lys Met
230 235AGCCTTTGGG CCATCCACCT AAAGGTTTTT 811
(2) Sequence 56 data:
(i) sequence characteristics:
(A) length: 237 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 56: met Lys Lys Ile Val Leu Val Ala Ile Ala Leu Leu Met Ser Ala Cys 151015 Ala Ser Tyr Lys Ile Thr Pro Glu His Val Thr Ser Tyr Asn Asn Gly
20 25 30Ile Gln Val Met Thr Ser Thr Gln Ala Lys Ser Lys Val Gln Leu Glu
35 40 45Ile Ala Gln Ser Lys Leu Lys Gly Leu Asn Glu Ser Pro Leu Val Leu
50 55 60Tyr Val Ala Ala Gln Val Ile Glu Gly Ser Pro Val Val Phe Ser Arg65 70 75 80Lys Ala Ile Ser Val Ser Ile Asn Gln Thr Asn Leu Pro Val Leu Ser
85 90 95Leu Arg Gln Val Met Lys Ser Ser Phe Asp Phe Glu Gly Ile Leu Gln
100 105 110Ser Phe Asn Ile Ala Val Pro Thr Thr Pro Ile Asp Asn Val Asn Met
115 120 125Ile Thr Pro Pro Met Phe Tyr Tyr Gly Gln Gly Gly Phe Leu Ala Tyr
130 135140Asn Gly Met Met Tyr Gly Gly Met Gly Met Tyr Gly Pro Gly Phe Gly145 150 155 160Met Met Met Met Asp Asp Val Glu Glu Gln Glu Val Met Gln Glu Ser
165 170 175Arg Gln Ala Leu Lys Ile Leu Ala Ile Asn Tyr Leu Lys Asn Asn Thr
180 185 190Leu Asn Val Glu Ser Lys Ala Lys Gly Gly Phe Val Val Val Asp Thr
195 200 205Lys Asn Leu Lys Thr Pro Gly Val Val Val Val Lys Val Phe Leu Glu
210 215 220Asp Glu Ile His Thr Phe Lys Ile Asp Ile Ser Lys Met225 230 235
(2) Sequence 57 data:
(i) sequence characteristics:
(A) length: 1425bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 97...1371
(D) Other information:
(xi) Description of the sequence: sequence 57: TAAAAAAAAC TACCCTTAAA AAAATCAATC TAAAATTCTT AAATTAAAAT ATAGCTATAA 60TACACTAAAA CAATCTCAAG GTTTCAAAAT TTAGCC ATG CGT CTT CTT CTG TTC 114
Met Arg Leu Leu Leu Phe
1 5AAT CAA AAC GCT TTT TTA TTA GCG TGC ATG TTT GTT TCA AGC GTG TAT 162Asn Gln Asn Ala PheLeu Leu Ala Cys Met Phe Val Ser Ser Val Tyr
10 15 20GTG AAC GCT GTC TTA GAC GCT TAT GCA ATT GAA AAC CCC TAT ATT TCT 210Val Asn Ala Val Leu Asp Ala Tyr Ala Ile Glu Asn Pro Tyr Ile Ser
25 30 35ATC ACA CTC ACA AGC CTA TTA GCC CCT TTA AGC ATG CTA GCG TTT TTA 258Ile Thr Leu Thr Ser Leu Leu Ala Pro Leu Ser Met Leu Ala Phe Leu
40 45 50AAA ACC CCT AGA AAT AGT GCT TTT GCT TTG GGG TTT TTT GTG GGG GCG 306Lys Thr Pro Arg Asn Ser Ala Phe Ala Leu Gly Phe Phe Val Gly Ala55 60 65 70TTA TTG TTT TAT TGG TGC GCT TTA AGC TTT CGC TAC TCG GAT TTC ACT 354Leu Leu Phe Tyr Trp Cys Ala Leu Ser Phe Arg Tyr Ser Asp Phe Thr
75 80 85TAT TTA TTG CCC TTA ATC ATT GTT TTA ATA GCG TTA GTT TAT GGG GTT 402Tyr Leu Leu Pro Leu Ile Ile Val Leu Ile Ala Leu Val Tyr Gly Val
90 95 100TTA TTT TAT TTG TTG CTC TAT TTT GAA AAC CCC TAT TTC AGG CTT TTG 450Leu Phe Tyr Leu Leu Leu Tyr Phe Glu Asn Pro Tyr Phe Arg Leu Leu
105 110 115AGT TTT TTA GGC TCT AGT TTT ATC CAC CCC TTT GGA TTT GAT TGG TTA 498Ser Phe Leu Gly Ser Ser Phe Ile His Pro Phe Gly Phe Asp Trp Leu
120 125 130GTC CCA GAT AGC TTT TTT TCT TAT AGC GTG TTT AGA GTG GAT AAA TTA 546Val Pro Asp Ser Phe Phe Ser Tyr Ser Val Phe Arg Val Asp Lys Leu135 140 145 150TCG CTA GGG CTT GTT TTT TTG GCT TGC ATT TTT TTG AGC ACT AAA CCA 594Ser Leu Gly Leu Val Phe Leu Ala Cys Ile Phe Leu Ser Thr Lys Pro
155 160 165TTG AAA AAA TAT AGG ATC ATA GGG GTT TTA TTG TTA CTT GGC GCG TTG 642Leu Lys Lys Tyr Arg Ile Ile Gly Val Leu Leu Leu Leu Gly Ala Leu
170 175 180GAT TTT AAT GGT TTC AAA ACA AGC GAT TTA AAA AAG GTT GGA AAT ATT 690Asp Phe Asn Gly Phe Lys Thr Ser Asp Leu Lys Lys Val Gly Asn Ile
185 190 195GAA TTA GTC TCT ACA AAA ACG CCC CAA GAT TTG AAA TTT GAC TCA AGT 738Glu Leu Val Ser Thr Lys Thr Pro Gln Asp Leu Lys Phe Asp Ser Ser
200 205 210TAC CTT AAT GAT ATT GAA AAC AAC ATT CTT AAA GAA ATC AAG CTC GCT 786Tyr Leu Asn Asp Ile Glu Asn Asn Ile Leu Lys Glu Ile Lys Leu Ala215 220 225 230CAA AGC AAG CAA AAA ACC TTG ATT GTT TTT CCA GAA ACC GCC TAC CCC 834Gln Ser Lys Gln Lys Thr Leu Ile Val Phe Pro Glu Thr Ala Tyr Pro
235 240 245ATC GCT TTA GAA AAC TCC CCC TTT AAA GCG AAG CTA GAA GAT TTA AGC 882Ile Ala Leu Glu Asn Ser Pro Phe Lys Ala Lys Leu Glu Asp Leu Ser
250 255 260GAT AAT ATT GCT ATT TTA ATA GGG ACA TTA CGG ACT CAA GGC TAT AAT 930Asp Asn Ile Ala Ile Leu Ile Gly Thr Leu Arg Thr Gln Gly Tyr Asn
265 270 275CTT TAT AAC AGC TCG TTT TTA TTT TCT AAA GAA AGC GTT CAG ATC GCT 978Leu Tyr Asn Ser Ser Phe Leu Phe Ser Lys Glu Ser Val Gln Ile Ala
280 285 290GAT AAA GTA ATT TTA GCC CCC TTT GGC GAG ACC ATG CCT TTA CCG GAA 1026Asp Lys Val Ile Leu Ala Pro Phe Gly Glu Thr Met Pro Leu Pro Glu295 300 305 310TTT CTT CAA AAA CCC CTT GAA AAG CTC TTT TTT GGC GAG AGC ACT TAT 1074Phe Leu Gln Lys Pro Leu Glu Lys Leu Phe Phe Gly Glu Ser Thr Tyr
315 320 325TTA TAC CGC AAT GCT CCT CAT TTC AGC GAT TTT ACA TTA GAC GAT TTT 1122Leu Tyr Arg Asn Ala Pro His Phe Ser Asp Phe Thr Leu Asp Asp Phe
330 335 340ACT TTT CGC CCC CTG ATT TGC TAT GAA GGC ACT TCC AAA CCC GCT TAT 1170Thr Phe Arg Pro Leu Ile Cys Tyr Glu Gly Thr Ser Lys Pro Ala Tyr
345 350 355TCA AAC AGC CCT TCA AAA ATT TTT ATC GTG ATG AGC AAT AAC GCA TGG 1218Ser Asn Ser Pro Ser Lys Ile Phe Ile Val Met Ser Asn Asn Ala Trp
360 365 370TTT AGC CCA AGC ATT GAA CCC ACC TTA CAA AGA ACG CTT TTA AAA TAC 1266Phe Ser Pro Ser Ile Glu Pro Thr Leu Gln Arg Thr Leu Leu Lys Tyr375 380 385 390TAC GCA AGG CGT TAT GAT AAG ATC ATC TTG CAC AGC GCG AAC TTT TCA 1314Tyr Ala Arg Arg Tyr Asp Lys Ile Ile Leu His Ser Ala Asn Phe Ser
395 400 405ACT TCT TAC ATC TTA AGC CCT AGT TTA TTA GGC GAT ATT CTT TTT AGG 1362Thr Ser Tyr Ile Leu Ser Pro Ser Leu Leu Gly Asp Ile Leu Phe Arg
410 415 420AAA CGA TCA TGATTAAAGC GATTAATATT TCTCATGCTT TTGAAAAGCC TCTTTATAA 1420Lys Arg Ser
425TGGCG 1425
(2) Sequence 58 data:
(i) sequence characteristics:
(A) length: 425 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 58: met Arg Leu Leu Leu Phe Asn Gln Asn Ala Phe Leu Leu Ala Cys Met 151015 Phe Val Ser Ser Val Tyr Val Asn Ala Val Leu Asp Ala Tyr Ala Ile
20 25 30Glu Asn Pro Tyr Ile Ser Ile Thr Leu Thr Ser Leu Leu Ala Pro Leu
35 40 45Ser Met Leu Ala Phe Leu Lys Thr Pro Arg Asn Ser Ala Phe Ala Leu
50 55 60Gly Phe Phe Val Gly Ala Leu Leu Phe Tyr Trp Cys Ala Leu Ser Phe65 70 75 80Arg Tyr Ser Asp Phe Thr Tyr Leu Leu Pro Leu Ile Ile Val Leu Ile
85 90 95Ala Leu Val Tyr Gly Val Leu Phe Tyr Leu Leu Leu Tyr Phe Glu Asn
100 105 110Pro Tyr Phe Arg Leu Leu Ser Phe Leu Gly Ser Ser Phe Ile His Pro
115 120 125Phe Gly Phe Asp Trp Leu Val Pro Asp Ser Phe Phe Ser Tyr Ser Val
130 135 140Phe Arg Val Asp Lys Leu Ser Leu Gly Leu Val Phe Leu Ala Cys Ile145 150 155 160Phe Leu Ser Thr Lys Pro Leu Lys Lys Tyr Arg Ile Ile Gly Val Leu
165 170 175Leu Leu Leu Gly Ala Leu Asp Phe Asn Gly Phe Lys Thr Ser Asp Leu
180 185 190Lys Lys Val Gly Asn Ile Glu Leu Val Ser Thr Lys Thr Pro Gln Asp
195 200 205Leu Lys Phe AspSer Ser Tyr Leu Asn Asp Ile Glu Asn Asn Ile Leu
210 215 220Lys Glu Ile Lys Leu Ala Gln Ser Lys Gln Lys Thr Leu Ile Val Phe225 230 235 240Pro Glu Thr Ala Tyr Pro lle Ala Leu Glu Asn Ser Pro Phe Lys Ala
245 250 255Lys Leu Glu Asp Leu Ser Asp Asn Ile Ala Ile Leu Ile Gly Thr Leu
260 265 270Arg Thr Gln Gly Tyr Asn Leu Tyr Asn Ser Ser Phe Leu Phe Ser Lys
275 280 285Glu Ser Val Gln Ile Ala Asp Lys Val Ile Leu Ala Pro Phe Gly Glu
290 295 300Thr Met Pro Leu Pro Glu Phe Leu Gln Lys Pro Leu Glu Lys Leu Phe305 310 315 320Phe Gly Glu Ser Thr Tyr Leu Tyr Arg Asn Ala Pro His Phe Ser Asp
325 330 335Phe Thr Leu Asp Asp Phe Thr Phe Arg Pro Leu Ile Cys Tyr Glu Gly
340 345 350Thr Ser Lys Pro Ala Tyr Ser Asn Ser Pro Ser Lys Ile Phe Ile Val
355 360 365Met Ser Asn Asn Ala Trp Phe Ser Pro Ser Ile Glu Pro Thr Leu Gln
370 375 380Arg Thr Leu Leu Lys Tyr Tyr Ala Arg Arg Tyr Asp Lys Ile Ile Leu385 390 395 400His Ser Ala Asn Phe Ser Thr Ser Tyr Ile Leu Ser Pro Ser Leu Leu
405 410 415Gly Asp Ile Leu Phe Arg Lys Arg Ser
420 425
(2) Sequence 59 data:
(i) sequence characteristics:
(A) length: 766bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...713
(D) Other information:
(xi) Description of the sequence: sequence 59: TGTAGTAAGA TACCTAGTTT TCAAATCTAT TAAAAGATAA AGGTTATTAC ATG TTT 56
Met Phe
1TCA CTT TCT TAT GTT TCC AAG AAA TTT TTA AGC GTT TTA TTA TTG ATT 104Ser Leu Ser Tyr Val Ser Lys Lys Phe Leu Ser Val Leu Leu Leu Ile
5 10 15TCG CTG TTT TTA AGC GCT TGC AAA TCC AAC AAT AAA GAC AAG TTA GAC 152Ser Leu Phe Leu Ser Ala Cys Lys Ser Asn Asn Lys Asp Lys Leu Asp
20 25 30GAA AAT CTT TTA AGC TCT GGC TCT CAA AGC TCC AAA GAA TTA AAC GAT 200Glu Asn Leu Leu Ser Ser Gly Ser Gln Ser Ser Lys Glu Leu Asn Asp35 40 45 50GAG CGA GAC AAT ATA GAC AAA AAG AGT TAC GCT GGT TTA GAA GAT GTT 248Glu Arg Asp Asn Ile Asp Lys Lys Ser Tyr Ala Gly Leu Glu Asp Val
55 60 65TTT TCA GAC AAT AAG TCC ATT AGT CCT AAC GAT AAA TAC ATG CTT TTA 296Phe Ser Asp Asn Lys Ser Ile Ser Pro Asn Asp Lys Tyr Met Leu Leu
70 75 80GTTTTT GGC CGT AAT GGT TGC TCC TAT TGC GAA AGG TTT AAA AAA GAT 344Val Phe Gly Arg Asn Gly Cys Ser Tyr Cys Glu Arg Phe Lys Lys Asp
85 90 95CTC AAA AAT GTC AAA GAA TTG CGC GAC TAC ATT AAA GAG CAT TTT AGC 392Leu Lys Asn Val Lys Glu Leu Arg Asp Tyr Ile Lys Glu His Phe Ser
100 105 110GCT TAC TAT GTC AAT ATC AGC TAC TCC AAA GAG CAT GAT TTT AAA GTC 440Ala Tyr Tyr Val Asn Ile Ser Tyr Ser Lys Glu His Asp Phe Lys Val115 120 125 130GGC GAT AAA AAT AAT GAA AAA GAA ATC AAA ATG TCC ACA GAA GAA TTA 488Gly Asp Lys Asn Asn Glu Lys Glu Ile Lys Met Ser Thr Glu Glu Leu
135 140 145GCG CAA ATT TAT GCC GTC CAA TCC ACC CCT ACG ATT GTT TTA TCC GAT 536Ala Gln Ile Tyr Ala Val Gln Ser Thr Pro Thr Ile Val Leu Ser Asp
150 155 160AAA ACC GGC AAA ACC ATC TAT GAA TTG CCC GGC TAT ATG CCC TCT ACG 584Lys Thr Gly Lys Thr Ile Tyr Glu Leu Pro Gly Tyr Met Pro Ser Thr
165 170 175CAA TTT TTA GCC GTG TTA GAA TTT ATC GGC GAT GGG AAG TAT CAA GAC 632Gln Phe Leu Ala Val Leu Glu Phe Ile Gly Asp Gly Lys Tyr Gln Asp
180 185 190ACA AAA GAC GAT GAG GAT CTC ACT AAA AAA TTA AAG GCT TAC ATC AAG 680Thr Lys Asp Asp Glu Asp Leu Thr Lys Lys Leu Lys Ala Tyr Ile Lys195 200 205 210TAT AAA ACC AAC CTT TCT AAA AGC AAG TCT AAC TAGGAAAGCC TAATGAAGAA 733Tyr Lys Thr Asn Leu Ser Lys Ser Lys Ser Asn
215 220TCTCAAAAGC CTGCTTTCTT TTTTGCTGGC TTC 766
(2) Sequence 60 data:
(i) sequence characteristics:
(A) length: 221 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 60: met Phe Ser Leu Ser Tyr Val Ser Lys Lys Phe Leu Ser Val Leu Leu 151015 Leu Ile Ser Leu Phe Leu Ser Ala Cys Lys Ser Asn Asn Lys Asp Lys
20 25 30Leu Asp Glu Asn Leu Leu Ser Ser Gly Ser Gln Ser Ser Lys Glu Leu
35 40 45Asn Asp Glu Arg Asp Asn Ile Asp Lys Lys Ser Tyr Ala Gly Leu Glu
50 55 60Asp Val Phe Ser Asp Asn Lys Ser Ile Ser Pro Asn Asp Lys Tyr Met65 70 75 80Leu Leu Val Phe Gly Arg Asn Gly Cys Ser Tyr Cys Glu Arg Phe Lys
85 90 95Lys Asp Leu Lys Asn Val Lys Glu Leu Arg Asp Tyr Ile Lys Glu His
100 105 110Phe Ser Ala Tyr Tyr Val Asn Ile Ser Tyr Ser Lys Glu His Asp Phe
115 120 125Lys Val Gly Asp Lys Asn Asn Glu Lys Glu Ile Lys Met Ser Thr Glu
130 135 140Glu Leu Ala Gln Ile Tyr Ala Val Gln Ser Thr Pro Thr Ile Val Leu145 150 155 160Ser Asp Lys Thr Gly Lys Thr Ile Tyr Glu Leu Pro Gly Tyr Met Pro
165 170 175Ser ThrGln Phe Leu Ala Val Leu Glu Phe Ile Gly Asp Gly Lys Tyr
180 185 190Gln Asp Thr Lys Asp Asp Glu Asp Leu Thr Lys Lys Leu Lys Ala Tyr
195 200 205Ile Lys Tyr Lys Thr Asn Leu Ser Lys Ser Lys Ser Asn
210 215 220
(2) Sequence 61 data:
(i) sequence characteristics:
(A) length: 980bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 53...931
(D) Other information:
(xi) Description of the sequence: sequence 61: TGAATGAAAT CCTAGATTCT AACGCCATTG TATATTATCT CGCTAAAAAT TC ATG AGA 58
Met Arg
1TTG TTA TTC TTG TTA TTG AGT GCT GCT TTT ATG TTA CTG GCT GAA GAA 106Leu Leu Phe Leu Leu Leu Ser Ala Ala Phe Met Leu Leu Ala Glu Glu
5 10 15AAA ATA TCT TTA AAC GAT GAC GCC CCC ATT AAA CTA GTG CAT TGG CAA 154Lys Ile Ser Leu Asn Asp Asp Ala Pro Ile Lys Leu Val His Trp Gln
20 25 30AAT GCA TTA AAA GAA GTC CAA CCT GAT TCA AAC GCT CCA GCA ACA CCA 202Asn Ala Leu Lys Glu Val Gln Pro Asp Ser Asn Ala Pro Ala Thr Pro35 40 45 50CCT ATA AAA GCC GTG CAA ACC ACG CTC ACT TTT GAA ACG CCT TTT AAC 250Pro Ile Lys Ala Val Gln Thr Thr Leu Thr Phe Glu Thr Pro Phe Asn
55 60 65AAA ACG CCT AAA ATC ATG GAA GTT GAA GGG CAA AAG GTG ATC GTC TTA 298Lys Thr Pro Lys Ile Met Glu Val Glu Gly Gln Lys Val Ile Val Leu
70 75 80AAA AAC GCT AAA CTG GAT TCT AAA AAA ACC ATG GAT TTT AAA GAA GCC 346Lys Asn Ala Lys Leu Asp Ser Lys Lys Thr Met Asp Phe Lys Glu Ala
85 90 95TCT TTG AAT GCT TTA GAA ATG TTT TCC TAC CAA AAT GAC ATC TAC CTC 394Ser Leu Asn Ala Leu Glu Met Phe Ser Tyr Gln Asn Asp Ile Tyr Leu
100 105 110TTG TCT AAA AAA GCT AAA GTG GAA TTA GAA ATC CAA GCT TCA AAC AGC 442Leu Ser Lys Lys Ala Lys Val Glu Leu Glu Ile Gln Ala Ser Asn Ser115 120 125 130AAG GAT AAA AAA CGG CTC CGC TTT CTC TTT TTA CCC AAA GGT TTT CAT 490Lys Asp Lys Lys Arg Leu Arg Phe Leu Phe Leu Pro Lys Gly Phe His
135 140 145TTA GCC CCA CCG CCT AAC CTG AAA GAA AAA TCT CAG CAA ACT AAC CTT 538Leu Ala Pro Pro Pro Asn Leu Lys Glu Lys Ser Gln Gln Thr Asn Leu
150 155 160GCA CAA AAA GAC ACC AAC GAG CAA CCC CAA AGC CCT TTA AAC ACT CTA 586Ala Gln Lys Asp Thr Asn Glu Gln Pro Gln Ser Pro Leu Asn Thr Leu
165 170 175GAG TTA AAA CCC CCA CTA AAT TTA AGC CAT GCT TAT AAG GCG CTA GCG 634Glu Leu Lys Pro Pro Leu Asn Leu Ser His Ala Tyr Lys Ala Leu Ala
180 185 190GTT ATT GCT GCC TTA CTC TTA ATA TTG TAT GTC ATC AAA AAA AAA ATT682Val Ile Ala Ala Leu Leu Leu Ile Leu Tyr Val Ile Lys Lys Lys Ile195 200 205 210GTT CCC ACA CAA GGG TCT TTT TCT GCA AAA GAT TTT AAG TTA GAA ATT 730Val Pro Thr Gln Gly Ser Phe Ser Ala Lys Asp Phe Lys Leu Glu Ile
215 220 225AGC GTT TTG GGT CGT GTT GAT GCG AAC CAT AAA ATC ATT TCA ATA GAA 778Ser Val Leu Gly Arg Val Asp Ala Asn His Lys Ile Ile Ser Ile Glu
230 235 240ACC AAT AAG GAG CGT TAC TTG GTC TTA CTA AGC GAT AAA TAC GGC CTG 826Thr Asn Lys Glu Arg Tyr Leu Val Leu Leu Ser Asp Lys Tyr Gly Leu
245 250 255CTT TTA GAC AAA ATA AGC CCA AAA ACA TCT AAA GAA GAA CTG ATT AAA 874Leu Leu Asp Lys Ile Ser Pro Lys Thr Ser Lys Glu Glu Leu Ile Lys
260 265 270GAA GCT GAA AAT AAT ATA AAG AAT TCA AAA TTA GGA AAT TTA TAT GCC 922Glu Ala Glu Asn Asn Ile Lys Asn Ser Lys Leu Gly Asn Leu Tyr Ala275 280 285 290GGA AAA TTC TAAACTACAA CCTGCTAAGT TAGGGAAAAA TTTTGACCCT GTGGATCAT 980Gly Lys Phe
(2) Sequence 62 data:
(i) sequence characteristics:
(A) length: 293 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 62: met Arg Leu Leu Phe Leu Leu Leu Ser Ala Ala Phe Met Leu Leu Ala 151015 Glu Glu Lys Ile Ser Leu Asn Asp Asp Ala Pro Ile Lys Leu Val His
20 25 30Trp Gln Asn Ala Leu Lys Glu Val Gln Pro Asp Ser Asn Ala Pro Ala
35 40 45Thr Pro Pro Ile Lys Ala Val Gln Thr Thr Leu Thr Phe Glu Thr Pro
50 55 60Phe Asn Lys Thr Pro Lys Ile Met Glu Val Glu Gly Gln Lys Val Ile65 70 75 80Val Leu Lys Asn Ala Lys Leu Asp Ser Lys Lys Thr Met Asp Phe Lys
85 90 95Glu Ala Ser Leu Asn Ala Leu Glu Met Phe Ser Tyr Gln Asn Asp Ile
100 105 110Tyr Leu Leu Ser Lys Lys Ala Lys Val Glu Leu Glu Ile Gln Ala Ser
115 120 125Asn Ser Lys Asp Lys Lys Arg Leu Arg Phe Leu Phe Leu Pro Lys Gly
130 135 140Phe His Leu Ala Pro Pro Pro Asn Leu Lys Glu Lys Ser Gln Gln Thr145 150 155 160Asn Leu Ala Gln Lys Asp Thr Asn Glu Gln Pro Gln Ser Pro Leu Asn
165 170 175Thr Leu Glu Leu Lys Pro Pro Leu Asn Leu Ser His Ala Tyr Lys Ala
180 185 190Leu Ala Val Ile Ala Ala Leu Leu Leu Ile Leu Tyr Val Ile Lys Lys
195 200 205Lys Ile Val Pro Thr Gln Gly Ser Phe Ser Ala Lys Asp Phe Lys Leu
210 215 220Glu Ile Ser Val Leu Gly Arg Val Asp Ala Asn His Lys Ile Ile Ser225 230 235 240Ile Glu Thr Asn Lys Glu Arg Tyr Leu Val Leu Leu Ser Asp Lys Tyr
245 250 255Gly Leu Leu Leu Asp Lys Ile Ser Pro Lys Thr Ser Lys Glu Glu Leu
260 265 270Ile Lys Glu Ala Glu Asn Asn Ile Lys Asn Ser Lys Leu Gly Asn Leu
275 280 285Tyr Ala Gly Lys Phe
290
(2) Sequence 63 data:
(i) sequence characteristics:
(A) length: 620bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...567
(D) Other information:
(xi) Description of the sequence: sequence 63: CTAGCGCGAT CTTTGGTCTC ACACAAGCTA TAACAAGCTT GAGAATCGCA TAATATATTC 60TTGTTCTAC ATG CTA TCA CCA GCA ACT TTC AAA CAA ATA ACT CTA GCA TTA 111
Met Leu Ser Pro Ala Thr Phe Lys Gln Ile Thr Leu Ala Leu
1 5 10ATC GCT TCA AGA CTA ATC GTT GTA ATC CTA TAT GCT TTT ATC TTT ATT 159Ile Ala Ser Arg Leu Ile Val Val Ile Leu Tyr Ala Phe Ile Phe Ile15 20 25 30GTT CTC TCT TTT TAT ATG CTC AAT ATC ATC ACT ATT CTT AAT TTT AAA 207Val Leu Ser Phe Tyr Met Leu Asn Ile Ile Thr Ile Leu Asn Phe Lys
35 40 45GCG CTT ATT TTG GGG TTT GTT AGT GTT TTT TCA AGC GCA TTG TTT TGT 255Ala Leu Ile Leu Gly Phe Val Ser Val Phe Ser Ser Ala Leu Phe Cys
50 55 60TTT TGC TTG GCA ATT TTT GTA GCT AGA ATT TTT CAA AAC GAA CAA AGC 303Phe Cys Leu Ala Ile Phe Val Ala Arg Ile Phe Gln Asn Glu Gln Ser
65 70 75ATC TTA GGA TTT TGT AAT ATC ATC AAT CTC TAT GCG CTA ATG TCT TGT 351Ile Leu Gly Phe Cys Asn Ile Ile Asn Leu Tyr Ala Leu Met Ser Cys
80 85 90AAT GTT TTT GTT CCT TTA GAA TAC CTA CCT AGT ATT GGT CAA TTA TTT 399Asn Val Phe Val Pro Leu Glu Tyr Leu Pro Ser Ile Gly Gln Leu Phe95 100 105 110ATC AAA ACA TCT ATT TTT TAC TAC CTT AAT CAA CTT CTA ATC AAA GCT 447Ile Lys Thr Ser Ile Phe Tyr Tyr Leu Asn Gln Leu Leu Ile Lys Ala
115 120 125TTT CAA GGG ATT GAT ACT ATA CTG GTT TTA GCA ACT TCA ACA TTT TTC 495Phe Gln Gly Ile Asp Thr Ile Leu Val Leu Ala Thr Ser Thr Phe Phe
130 135 140ATT ATT GGT GGC ATT ATT TTA TTT TTA CTA AGC GCT AAT CGC ATG TTA 543Ile Ile Gly Gly Ile Ile Leu Phe Leu Leu Ser Ala Asn Arg Met Leu
145 150 155CTA ACA CCA AAA GAA CGC ATG CGT TAAAGGCTTA GTCCCACCAT TGATTTATTT 597Leu Thr Pro Lys Glu Arg Met Arg
160 165AATGGCTCAA AAAAGGGGTA AGC 620
(2) Sequence 64 data:
(i) sequence characteristics:
(A) length: 166 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 64: met Leu Ser Pro Ala Thr Phe Lys Gln Ile Thr Leu Ala Leu Ile Ala 151015 Ser Arg Leu Ile Val Val Ile Leu Tyr Ala Phe Ile Phe Ile Val Leu
20 25 30Ser Phe Tyr Met Leu Asn Ile Ile Thr Ile Leu Asn Phe Lys Ala Leu
35 40 45Ile Leu Gly Phe Val Ser Val Phe Ser Ser Ala Leu Phe Cys Phe Cys
50 55 60Leu Ala Ile Phe Val Ala Arg Ile Phe Gln Asn Glu Gln Ser Ile Leu65 70 75 80Gly Phe Cys Asn Ile Ile Asn Leu Tyr Ala Leu Met Ser Cys Asn Val
85 90 95Phe Val Pro Leu Glu Tyr Leu Pro Ser Ile Gly Gln Leu Phe Ile Lys
100 105 110Thr Ser Ile Phe Tyr Tyr Leu Asn Gln Leu Leu Ile Lys Ala Phe Gln
115 120 125Gly Ile Asp Thr Ile Leu Val Leu Ala Thr Ser Thr Phe Phe Ile Ile
130 135 140Gly Gly Ile Ile Leu Phe Leu Leu Ser Ala Asn Arg Met Leu Leu Thr145 150 155 160Pro Lys Glu Arg Met Arg
165
(2) Sequence 65 data:
(i) sequence characteristics:
(A) length: 1405bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...1366
(D) Other information:
(xi) Description of the sequence: sequence 65: ATTGATTTCT TTTGGGAAGT GGATTTGAAA AACTTAAAAA GCCATTAAC ATG CAA GTT 58
Met Gln Val
1AAA GAA AAC AAA CAA CTC TGC TTA ATT TCA TTA GGT TGC TCT AAA AAT 106Lys Glu Asn Lys Gln Leu Cys Leu Ile Ser Leu Gly Cys Ser Lys Asn
5 10 15TTG GTG GAT TCA GAG GTG ATG TTA GGC AAG CTT TAT AAT TAC ACG CTC 154Leu Val Asp Ser Glu Val Met Leu Gly Lys Leu Tyr Asn Tyr Thr Leu20 25 30 35ACT AAT GAC GCT AAG AGC GCT GAT GTG ATT TTG ATC AAC ACT TGC GGG 202Thr Asn Asp Ala Lys Ser Ala Asp Val Ile Leu Ile Asn Thr Cys Gly
40 45 50TTT ATT GAA AGC GCT AAA CAA GAG AGT ATC CAA ACC ATT CTC AAC GCC 250Phe Ile Glu Ser Ala Lys Gln Glu Ser Ile Gln Thr Ile Leu Asn Ala
55 60 65GCC AAA GAC AAA AAA GAG GGA GCG ATT TTG ATT GCG AGC GGG TGC TTG 298Ala Lys Asp Lys Lys Glu Gly Ala Ile Leu Ile Ala Ser Gly Cys Leu
70 75 80AGC GAA CGC TAT AAA GAT GAA ATC AAA GAA TTG ATC CCT GAA GTG GAT 346Ser Glu Arg Tyr Lys Asp Glu Ile Lys Glu Leu Ile Pro Glu Val Asp
85 90 95ATT TTT ACC GGC GTG GGG GAT TAT GAC AAG ATC GAT ATA ATG ATT GCT 394Ile Phe Thr Gly Val Gly Asp Tyr Asp Lys Ile Asp Ile Met Ile Ala100 105 110 115AAA AAA CAA AAC CAG TTC AGC GAG CAA GTG TTT TTA AGC GAG CAT TAC 442Lys Lys Gln Asn Gln Phe Ser Glu Gln Val Phe Leu Ser Glu His Tyr
120 125 130AAC GCA CGC ATC ATC ACG GGA TCG ACC GTG CAT GCG TAT GTG AAA ATT 490Asn Ala Arg Ile Ile Thr Gly Ser Ser Val His Ala Tyr Val Lys Ile
135 140 145TCT GAG GGT TGC AAT CAA AAA TGT TCT TTT TGC GCT ATC CCT AGC TTT 538Ser Glu Gly Cys Asn Gln Lys Cys Ser Phe Cys Ala Ile Pro Ser Phe
150 155 160AAG GGG AAA TTG CAA AGC AGG GAA TTG GAC TCC ATT TTA AAA GAA GTG 586Lys Gly Lys Leu Gln Ser Arg Glu Leu Asp Ser Ile Leu Lys Glu Val
165 170 175GAA AAT CTC GCG CTT AAA GGC TAT ACG GAT ATG ACT TTT ATC GCT CAA 634Glu Asn Leu Ala Leu Lys Gly Tyr Thr Asp Met Thr Phe Ile Ala Gln180 185 190 195GAC TCT AGC TCC TTT TTA TAC GAT AAG GGG CAA AAA GAC GGC TTG ATC 682Asp Ser Ser Ser Phe Leu Tyr Asp Lys Gly Gln Lys Asp Gly Leu Ile
200 205 210CAG CTC ATT AGA GCG ATT GAT AAA CAG CAA GCC TTA AAG AGC GCG CGT 730Gln Leu Ile Arg Ala Ile Asp Lys Gln Gln Ala Leu Lys Ser Ala Arg
215 220 225ATT TTA TAT CTC TAC CCC TCT AGC ACC ACG CTA GAG CTT ATT GGC GCG 778Ile Leu Tyr Leu Tyr Pro Ser Ser Thr Thr Leu Glu Leu Ile Gly Ala
230 235 240ATT GAA AGT TCG CCC ATT TTT CAA AAT TAT TTT GAC ATG CCC ATC CAG 826Ile Glu Ser Ser Pro Ile Phe Gln Asn Tyr Phe Asp Met Pro Ile Gln
245 250 255CAC ATC AGC GAC TCC ATG CTC AAA AAG ATG CGG CGC AAC TCT AGC CAA 874His Ile Ser Asp Ser Met Leu Lys Lys Met Arg Arg Asn Ser Ser Gln260 265 270 275GCG CAC CAT TTA AAG CTT TTA GAT GCC ATG AAG CAG GTT AAA GAA AGC 922Ala His His Leu Lys Leu Leu Asp Ala Met Lys Gln Val Lys Glu Ser
280 285 290TTT ATC AGA AGC ACG ATC ATT GTA GGG CAT CCG GAA GAA AAT GAG AGC 970Phe Ile Arg Ser Thr Ile Ile Val Gly His Pro Glu Glu Asn Glu Ser
295 300 305GAA TTT GAA GAA TTG AGC GCG TTT TTA GAC GAG TTC CAG TTT GAT AGA 1018Glu Phe Glu Glu Leu Ser Ala Phe Leu Asp Glu Phe Gln Phe Asp Arg
310 315 320TTG AAT ATT TTT GCT TTC AGC GCT GAA GAA AAC ACG CAT GCC TAT TCT 1066Leu Asn Ile Phe Ala Phe Ser Ala Glu Glu Asn Thr His Ala Tyr Ser
325 330 335TTA GAA AAA GTG CCT AAA AAA ACC ATC AAC GCT CGC ATC AAA GCC TTG 1114Leu Glu Lys Val Pro Lys Lys Thr Ile Asn Ala Arg Ile Lys Ala Leu340 345 350 355AAT AAA ATC GCT TTA AAG CAC CAA AAC CAT TCC TTT AAG GCT TTG TTG 1162Asn Lys Ile Ala Leu Lys His Gln Asn His Ser Phe Lys Ala Leu Leu
360 365 370AAT AAG CCC ATT AAG GCG TTA GTG GAA AAT AAA GAG GGC GAG TAT TTT 1210Asn Lys Pro Ile Lys Ala Leu Val Glu Asn Lys Glu Gly Glu Tyr Phe
375 380 385TAC AAA GCA AGG GAT CTC AGA TGG GCG CCT GAA GTG GAT GGG GAA ATC 1258Tyr Lys Ala Arg Asp Leu Arg Trp Ala Pro Glu Val Asp Gly Glu Ile
390 395 400TTG ATC AAT GAT AGC GAA CTA ACC ACC CCC TTA AAA CCC GGG CAT TAT 1306Leu Ile Asn Asp Ser Glu Leu Thr Thr Pro Leu Lys Pro Gly His Tyr
405 410 415ACG ATT GCA CCT AGC GAA TTT AAA GAT AAT ATC CTA CTC GCT AAG GTT 1354Thr Ile Ala Pro Ser Glu Phe Lys Asp Asn Ile Leu Leu Ala Lys Val420 425 430 435TTA AGC CCT TTT TAAAAGTTAG CCATAAGGCT AAAAGCACGG CTAAAGCGT 1405Leu Ser Pro Phe
(2) Sequence 66 data:
(i) sequence characteristics:
(A) length: 439 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 66: met Gln Val Lys Glu Asn Lys Gln Leu Cys Leu Ile Ser Leu Gly Cys 151015 Ser Lys Asn Leu Val Asp Ser Glu Val Met Leu Gly Lys Leu Tyr Asn
20 25 30Tyr Thr Leu Thr Asn Asp Ala Lys Ser Ala Asp Val Ile Leu Ile Asn
35 40 45Thr Cys Gly Phe Ile Glu Ser Ala Lys Gln Glu Ser Ile Gln Thr Ile
50 55 60Leu Asn Ala Ala Lys Asp Lys Lys Glu Gly Ala Ile Leu Ile Ala Ser65 70 75 80Gly Cys Leu Ser Glu Arg Tyr Lys Asp Glu Ile Lys Glu Leu Ile Pro
85 90 95Glu Val Asp Ile Phe Thr Gly Val Gly Asp Tyr Asp Lys Ile Asp Ile
100 105 110Met Ile Ala Lys Lys Gln Asn Gln Phe Ser Glu Gln Val Phe Leu Ser
115 120 125Glu His Tyr Asn Ala Arg Ile Ile Thr Gly Ser Ser Val His Ala Tyr
130 135 140Val Lys Ile Ser Glu Gly Cys Asn Gln Lys Cys Ser Phe Cys Ala Ile145 150 155 160Pro Ser Phe Lys Gly Lys Leu Gln Ser Arg Glu Leu Asp Ser Ile Leu
165 170 175Lys Glu Val Glu Asn Leu Ala Leu Lys Gly Tyr Thr Asp Met Thr Phe
180 185 190Ile Ala Gln Asp Ser Ser Ser Phe Leu Tyr Asp Lys Gly Gln Lys Asp
195 200 205Gly Leu Ile Gln Leu Ile Arg Ala Ile Asp Lys Gln Gln Ala Leu Lys
210 215 220Ser Ala Arg Ile Leu Tyr Leu Tyr Pro Ser Ser Thr Thr Leu Glu Leu225 230 235 240Ile Gly Ala Ile Glu Ser Ser Pro Ile Phe Gln Asn Tyr Phe Asp Met
245 250 255Pro Ile Gln His Ile Ser Asp Ser Met Leu Lys Lys Met Arg Arg Asn
260 265 270Ser Ser Gln Ala His His Leu Lys Leu Leu Asp Ala Met Lys Gln Val
275 280 285Lys Glu Ser Phe Ile Arg Ser Thr Ile Ile Val Gly His Pro Glu Glu
290 295 300Asn Glu Ser Glu Phe Glu Glu Leu Ser Ala Phe Leu Asp Glu Phe Gln305 310 315 320Phe Asp Arg Leu Asn Ile Phe Ala Phe Ser Ala Glu Glu Asn Thr His
325 330 335Ala Tyr Ser Leu Glu Lys Val Pro Lys Lys Thr Ile Asn Ala Arg Ile
340345 350Lys Ala Leu Asn Lys Ile Ala Leu Lys His Gln Asn His Ser Phe Lys
355 360 365Ala Leu Leu Asn Lys Pro Ile Lys Ala Leu Val Glu Asn Lys Glu Gly
370 375 380Glu Tyr Phe Tyr Lys Ala Arg Asp Leu Arg Trp Ala Pro Glu Val Asp385 390 395 400Gly Glu Ile Leu Ile Asn Asp Ser Glu Leu Thr Thr Pro Leu Lys Pro
405 410 415Gly His Tyr Thr Ile Ala Pro Ser Glu Phe Lys Asp Asn Ile Leu Leu
420 425 430Ala Lys Val Leu Ser Pro Phe
435
(2) Sequence 67 data:
(i) sequence characteristics:
(A) length: 1420bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 200...1366
(D) Other information:
(xi) Description of the sequence: sequence 67: TGCGCGTTAT RTGGTTTTGA TTGAAAAGTT AGGCATTAAA GACAGATAAT TTTTATCGGT 60TTTAGGGTGT GGCGAGTTTG TGTTGAAAGA GCGTTTGAAG GCCTTTTTTA GTGCGGACTC 120TGTTTTCACT TTAATTTTTG CCCTTTTCTT TCTCACTTCG TTTAAAAAAC CTTTAACTCA 180AGTCTTGTTG ATTGTTTTA ATG GTT TTT TTG TTT TTT AGG TGT TAT TTC CAA 232
Met Val Phe Leu Phe Phe Arg Cys Tyr Phe Gln
15 10GCG TCT TTG AAA GAA ACT TTC GCA ATT AAT CAT TTA AAA ACA ATG TCT 280Ala Ser Leu Lys Glu Thr Phe Ala Ile Asn His Leu Lys Thr Met Ser
15 20 25TTT AAA TGG CTC ACT CTG GCT TTT TTG GGC GTG TTT TTA AGC ATC TTC 328Phe Lys Trp Leu Thr Leu Ala Phe Leu Gly Val Phe Leu Ser Ile Phe
30 35 40CCT AAC ATG TTT AAC ATG CAT GAT AGC CAA ACT TTC CGC TAC AAT TTA 376Pro Asn Met Phe Asn Met His Asp Ser Gln Thr Phe Arg Tyr Asn Leu
45 50 55TTC GCT CTA AAC ATG TCC TTA ACT TAT GCT TGC GGG GCG TTA TGC TTG 424Phe Ala Leu Asn Met Ser Leu Thr Tyr Ala Cys Gly Ala Leu Cys Leu60 65 70 75CTT TTT GCC AGT TGC TTA AGA ATC AAA TTG AAT CAA AAA ATC CTT TTT 472Leu Phe Ala Ser Cys Leu Arg Ile Lys Leu Asn Gln Lys Ile Leu Phe
80 85 90TAC AGC ATG GCT GTT GCA AAT TTC ATC AAC GGC TTG CTC TCA TTG GTG 520Tyr Ser Met Ala Val Ala Asn Phe Ile Asn Gly Leu Leu Ser Leu Val
95 100 105CAA AAA ATT TAT TTT AAC ATG CCC AGA GCG CAA GGG TTT AGC ACG GTT 568Gln Lys Ile Tyr Phe Asn Met Pro Arg Ala Gln Gly Phe Ser Thr Val
110 115 120AAG GAG TAT GTG GTT TTA GTG AGC GTG TCC ATT TTA GGC TGT TAT ATT 616Lys Glu Tyr Val Val Leu Val Ser Val Ser Ile Leu Gly Cys Tyr Ile
125 130 135TAT GCG CTT TAT TCG CAC AAT CAA AAA GAA AAA CTT TTT TTC ACG CTT 664Tyr Ala Leu Tyr Ser His Asn Gln Lys Glu Lys Leu Phe Phe Thr Leu140 145 150 155TCT GTT TTT GTG GGG TTT TTA GTC GTT ATT TTA AGC GCC ACA AGG AGC712Ser Val Phe Val Gly Phe Leu Val Val Ile Leu Ser Ala Thr Arg Ser
160 165 170GCG ACA ATC GCT TTT GTT ATT ACT TTT TTA ATC CTT TCT TGC TTT ATT 760Ala Thr Ile Ala Phe Val Ile Thr Phe Leu Ile Leu Ser Cys Phe Ile
175 180 185TTA TAC GCC AAA AAA TCG CTC AAA CCA TTG GGT TAT ATG GTG GTC GTG 808Leu Tyr Ala Lys Lys Ser Leu Lys Pro Leu Gly Tyr Met Val Val Val
190 195 200AGT CTT ATT TTG AGC GCT TTG TAT GTG GGG AGT AAC GCT TTA GAA AAA 856Ser Leu Ile Leu Ser Ala Leu Tyr Val Gly Ser Asn Ala Leu Glu Lys
205 210 215AAG GGG GCA ATA GAG CAA TCT AGA GTT CAA AAT CAA AGC TTT GAA GAA 904Lys Gly Ala Ile Glu Gln Ser Arg Val Gln Asn Gln Ser Phe Glu Glu220 225 230 235GAT CTG AAA CGC TAC GCT AAA AAG GAC GCT GAT AGC AGT ATC GGA TGG 952Asp Leu Lys Arg Tyr Ala Lys Lys Asp Ala Asp Ser Ser Ile Gly Trp
240 245 250CGT TTG GAG CGT TGG AAA GAA GCC CTA ACG GTT TTG CGT TTA AGG CCC 1000Arg Leu Glu Arg Trp Lys Glu Ala Leu Thr Val Leu Arg Leu Arg Pro
255 260 265TTT TTT GGT ATG GCC GCT AGC GAG AAA TGC CAG AGG TTA GAA GAG ATT 1048Phe Phe Gly Met Ala Ala Ser Glu Lys Cys Gln Arg Leu Glu Glu Ile
270 275 280TTA TCC TTA TCA AAG TCT TAT AGG GCC AAA GAT TTG ATT CTC TGT TAT 1096Leu Ser Leu Ser Lys Ser Tyr Arg Ala Lys Asp Leu Ile Leu Cys Tyr
285 290 295GAA AGA TAC GAC AAT CAA ATC ATT CAC ATT TTA GCC ACT AGG GGG ATC 1144Glu Arg Tyr Asp Asn Gln Ile Ile His Ile Leu Ala Thr Arg Gly Ile300 305310 315ATA GGC TTT TTG ATC TGG CTC TTT TTT TTA TTA GTT ATT GTA AAG ATT 1192Ile Cly Phe Leu Ile Trp Leu Phe Phe Leu Leu Val Ile Val Lys Ile
320 325 330TTT TGG AGC GGG ATA AAG CAA AAC TCT TTA ATA TCG TTT TTT ATA CTA 1240Phe Trp Ser Gly Ile Lys Gln Asn Ser Leu Ile Ser Phe Phe Ile Leu
335 340 345ATG ACA CTC GCC TTT TAC CTC ATT TTT GGC ATT GGG TTT GAC CCC TTT 1288Met Thr Leu Ala Phe Tyr Leu Ile Phe Gly Ile Gly Phe Asp Pro Phe
350 355 360GAT TTC TTC ATT ACG GGA AGT TTT TTT GTA GGA ATG ATC ATG ATG GCT 1336Asp Phe Phe Ile Thr Gly Ser Phe Phe Val Gly Met Ile Met Met Ala
365 370 375GTT TTT TTA AAA AAA GAT AAA AGT GCT TTT TAGCATCAAG GGGTTTGACA TTA 1389Val Phe Leu Lys Lys Asp Lys Ser Ala Phe380 385GTCAAGCGGT AGTTTCTTGT GATTCGTTCT T 1420
(2) Sequence 68 data:
(i) sequence characteristics:
(A) length: 389 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 68: met Val Phe Leu Phe Phe Arg Cys Tyr Phe Gln Ala Ser Leu Lys Glu 151015 Thr Phe Ala Ile Asn His Leu Lys Thr Met Ser Phe Lys Trp Leu Thr
20 25 30Leu Ala Phe Leu Gly Val Phe Leu Ser Ile Phe Pro Asn Met Phe Asn
35 40 45Met His Asp Ser Gln Thr Phe Arg Tyr Asn Leu Phe Ala Leu Asn Met
50 55 60Ser Leu Thr Tyr Ala Cys Gly Ala Leu Cys Leu Leu Phe Ala Ser Cys65 70 75 80Leu Arg Ile Lys Leu Asn Gln Lys Ile Leu Phe Tyr Ser Met Ala Val
85 90 95Ala Asn Phe Ile Asn Gly Leu Leu Ser Leu Val Gln Lys Ile Tyr Phe
100 105 110Asn Met Pro Arg Ala Gln Gly Phe Ser Thr Val Lys Glu Tyr Val Val
115 120 125Leu Val Ser Val Ser Ile Leu Gly Cys Tyr Ile Tyr Ala Leu Tyr Ser
130 135 140His Asn Gln Lys Glu Lys Leu Phe Phe Thr Leu Ser Val Phe Val Gly145 150 155 160Phe Leu Val Val Ile Leu Ser Ala Thr Arg Ser Ala Thr Ile Ala Phe
165 170 175Val Ile Thr Phe Leu Ile Leu Ser Cys Phe Ile Leu Tyr Ala Lys Lys
180 185 190Ser Leu Lys Pro Leu Gly Tyr Met Val Val Val Ser Leu Ile Leu Ser
195 200 205Ala Leu Tyr Val Gly Ser Asn Ala Leu Glu Lys Lys Gly Ala Ile Glu
210 215 220Gln Ser Arg Val Gln Asn Gln Ser Phe Glu Glu Asp Leu Lys Arg Tyr225 230 235 240Ala Lys Lys Asp Ala Asp Ser Ser Ile Gly Trp Arg Leu Glu Arg Trp
245 250 255Lys Glu Ala Leu Thr Val Leu Arg Leu Arg Pro Phe Phe Gly Met Ala
260265 270Ala Ser Glu Lys Cys Gln Arg Leu Glu Glu Ile Leu Ser Leu Ser Lys
275 280 285Ser Tyr Arg Ala Lys Asp Leu Ile Leu Cys Tyr Glu Arg Tyr Asp Asn
290 295 300Gln Ile Ile His Ile Leu Ala Thr Arg Gly Ile Ile Gly Phe Leu Ile305 310 315 320Trp Leu Phe Phe Leu Leu Val Ile Val Lys Ile Phe Trp Ser Gly Ile
325 330 335Lys Gln Asn Ser Leu Ile Ser Phe Phe Ile Leu Met Thr Leu Ala Phe
340 345 350Tyr Leu Ile Phe Gly Ile Gly Phe Asp Pro Phe Asp Phe Phe Ile Thr
355 360 365Gly Ser Phe Phe Val Gly Met Ile Met Met Ala Val Phe Leu Lys Lys
370 375 380Asp Lys Ser Ala Phe385
(2) Sequence 69 data:
(i) sequence characteristics:
(A) length: 1252bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 89...1198
(D) Other information:
(xi) Description of the sequence: sequence 69: AAAAAGGAAA TAGCACGATG AAACCTAAAG GGGATATTAG CGTTAATATG CTAATATAGT 60AGAACATTAT GACTACAAAA AGGGTGAT ATG CTG ATC TCC ATA GCG TTT TTA 112
Met Leu Ile Ser Ile Ala Phe Leu
1 5TTG GTT TTA TAT CTT TTG AAT TAT AGT TCT TTC AGG ATG TTG AAA TCG 160Leu Val Leu Tyr Leu Leu Asn Tyr Ser Ser Phe Arg Met Leu Lys Ser
10 15 20TTT TTA ACC TTA AAG AAA ATC TCT CAA TAC GCT TAT TTA TGG TTT TTT 208Phe Leu Thr Leu Lys Lys Ile Ser Gln Tyr Ala Tyr Leu Trp Phe Phe25 30 35 40ATC CTT TTG AGC ATA GGC GAG GCG GCT TTT GTT TTT TAT AGA AAT ATT 256Ile Leu Leu Ser Ile Gly Glu Ala Ala Phe Val Phe Tyr Arg Asn Ile
45 50 55ATG CCT AGC CAT TTG TTT GTT TTG ACT TCA GCG TGT TCG TTT GTG TCT 304Met Pro Ser His Leu Phe Val Leu Thr Ser Ala Cys Ser Phe Val Ser
60 65 70TTT ATT ATT TTT ATC CTT TCT TTA AGT TTT TAC GGG TTT TCC TAT TCC 352Phe Ile Ile Phe Ile Leu Ser Leu Ser Phe Tyr Gly Phe Ser Tyr Ser
75 80 85ATA GAA AAA ATA GAT TTT TTG CAT TCA AGG CGT AAA AGT TTA AAA AAC 400Ile Glu Lys Ile Asp Phe Leu His Ser Arg Arg Lys Ser Leu Lys Asn
90 95 100TTT TTA AAA TTG GGG TTT TAT CTG GCG TTA TTA GGG TAT TTT TGG CGT 448Phe Leu Lys Leu Gly Phe Tyr Leu Ala Leu Leu Gly Tyr Phe Trp Arg105 110 115 120GGG TTT TAT GAA GGG TTG GCC CGC CCT AAA ATC AAA GAA ACC CCT ATT 496Gly Phe Tyr Glu Gly Leu Ala Arg Pro Lys Ile Lys Glu Thr Pro Ile
125 130 135TAT TTG GAT AAG CTG GAT AAA GAA TTA AAG ATT ATT TTA CTC ACA GAC 544Tyr Leu Asp Lys Leu Asp Lys Glu Leu Lys Ile Ile Leu Leu Thr Asp
140145 150ATG CAT GTG GGG AGT TTG TTG CAA AAA GAT TTT GTT GAT TAC ATT GTA 592Met His Val Gly Ser Leu Leu Gln Lys Asp Phe Val Asp Tyr Ile Val
155 160 165GAA GAA GTC AAT CAA AAA GAA GTG GAT ATG GTG CTG ATT GGG GGG GAT 640Glu Glu Val Asn Gln Lys Glu Val Asp Met Val Leu Ile Gly Gly Asp
170 175 180TTA GTG GAT GAA AGC ATT GAA AAA GTC AAA TCT TTT TTA CTG CCT TTA 688Leu Val Asp Glu Ser Ile Glu Lys Val Lys Ser Phe Leu Leu Pro Leu185 190 195 200AAC AAC CTT AAA AGC ACG CAT GGC ACT TTT TAT GTG CCA GGA AAT CAT 736Asn Asn Leu Lys Ser Thr His Gly Thr Phe Tyr Val Pro Gly Asn His
205 210 215GAG TAT TAT CAT GGC ATA GAG CCG ATT TTA TCG TTT CTT GAC ACG CTT 784Glu Tyr Tyr His Gly Ile Glu Pro Ile Leu Ser Phe Leu Asp Thr Leu
220 225 230AAT TTG ACG ATT TTA GGG AAT GAG TGC GTG CAT TTA GGG GGG ATC AAT 832Asn Leu Thr Ile Leu Gly Asn Glu Cys Val His Leu Gly Gly Ile Asn
235 240 245TTG TGC GGC GTG TAT GAT TAT TTC GCA AGG AAG CGT CAA AAT TTT GCC 880Leu Cys Gly Val Tyr Asp Tyr Phe Ala Arg Lys Arg Gln Asn Phe Ala
250 255 260CCT GAT ATT GAC AAA GCT TTA AAA AAG CGC AAT GAG AGT AAG CCC ACG 928Pro Asp Ile Asp Lys Ala Leu Lys Lys Arg Asn Glu Ser Lys Pro Thr265 270 275 280ATC CTT TTG GCC CAC CAA CCT AAA CAA ATT AGA AGC CTC AAA GAA AGC 976Ile Leu Leu Ala His Gln Pro Lys Gln Ile Arg Ser Leu Lys Glu Ser
285 290 295CAC TCT GTA GAT TTA GTC CTT TCA GGG CAT ACC CAT GCA GGG CAA ATC1024His Ser Val Asp Leu Val Leu Ser Gly His Thr His Ala Gly Gln Ile
300 305 310TTT CCC TTT AGC CTT TTA GTC AAG TTG GCG CAA ACC TAT TTA CAT GGT 1072Phe Pro Phe Ser Leu Leu Val Lys Leu Ala Gln Thr Tyr Leu His Gly
315 320 325TTA TAC AAG CAC AGC CCC ACC ACT CAA ATT TAT GTG AGC AGT GGG GCA 1120Leu Tyr Lys His Ser Pro Thr Thr Gln Ile Tyr Val Ser Ser Gly Ala
330 335 340GGG TAT TGG GGG ATT CCT TTA AGG TTT TTA GCC CCT AGC GAG ATC GCA 1168Gly Tyr Trp Gly Ile Pro Leu Arg Phe Leu Ala Pro Ser Glu Ile Ala345 350 355 360TAC CTT AGG CTT TTA CCT AAA AAT CAA GCT TAGTTAAACA AAATCTTAAA ATC 1221Tyr Leu Arg Leu Leu Pro Lys Asn Gln Ala
365 370TTAATCGTAA TCAAGCGGTT AAAAATAAGA A 1252
(2) Sequence 70 data:
(i) sequence characteristics:
(A) length: 370 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 70: met Leu Ile Ser Ile Ala Phe Leu Leu Val Leu Tyr Leu Leu Asn Tyr 151015 Ser Ser Phe Arg Met Leu Lys Ser Phe Leu Thr Leu Lys Lys Ile Ser
20 25 30Gln Tyr Ala Tyr Leu Trp Phe Phe Ile Leu Leu Ser Ile Gly Glu Ala
35 40 45Ala Phe Val Phe Tyr Arg Asn Ile Met Pro Ser His Leu Phe Val Leu
50 55 60Thr Ser Ala Cys Ser Phe Val Ser Phe Ile Ile Phe Ile Leu Ser Leu65 70 75 80Ser Phe Tyr Gly Phe Ser Tyr Ser Ile Glu Lys Ile Asp Phe Leu His
85 90 95Ser Arg Arg Lys Ser Leu Lys Asn Phe Leu Lys Leu Gly Phe Tyr Leu
100 105 110Ala Leu Leu Gly Tyr Phe Trp Arg Gly Phe Tyr Glu Gly Leu Ala Arg
115 120 125Pro Lys Ile Lys Glu Thr Pro Ile Tyr Leu Asp Lys Leu Asp Lys Glu
130 135 140Leu Lys Ile Ile Leu Leu Thr Asp Met His Val Gly Ser Leu Leu Gln145 150 155 160Lys Asp Phe Val Asp Tyr Ile Val Glu Glu Val Asn Gln Lys Glu Val
165 170 175Asp Met Val Leu Ile Gly Gly Asp Leu Val Asp Glu Ser Ile Glu Lys
180 185 190Val Lys Ser Phe Leu Leu Pro Leu Asn Asn Leu Lys Ser Thr His Gly
195 200 205Thr Phe Tyr Val Pro Gly Asn His Glu Tyr Tyr His Gly Ile Glu Pro
210 215 220Ile Leu Ser Phe Leu Asp Thr Leu Asn Leu Thr Ile Leu Gly Asn Glu225 230 235 240Cys Val His Leu Gly Gly Ile Asn Leu Cys Gly Val Tyr Asp Tyr Phe
245 250 255Ala Arg Lys Arg Gln Asn Phe Ala Pro Asp Ile Asp Lys Ala Leu Lys
260 265 270Lys Arg Asn Glu Ser Lys Pro Thr Ile Leu Leu Ala His Gln Pro Lys
275 280 285Gln Ile Arg Ser Leu Lys Glu Ser His Ser Val Asp Leu Val Leu Ser
290 295 300Gly His Thr His Ala Gly Gln Ile Phe Pro Phe Ser Leu Leu Val Lys305 310 315 320Leu Ala Gln Thr Tyr Leu His Gly Leu Tyr Lys His Ser Pro Thr Thr
325 330 335Gln Ile Tyr Val Ser Ser Gly Ala Gly Tyr Trp Gly Ile Pro Leu Arg
340 345 350Phe Leu Ala Pro Ser Glu Ile Ala Tyr Leu Arg Leu Leu Pro Lys Asn
355 360 365Gln Ala
370
(2) Sequence 71 data:
(i) sequence characteristics:
(A) length: 431bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 103...381
(D) Other information:
(xi) Description of the sequence: sequence 71: AGTCTTTGCC CGCTATCAAA AAAGAGATTT TTTGCAATAT TTTCATAAGC ACCGAAGAAA 60GCTTGCTTTA GCGAGTTTGT GGGTGAAACG TACGCCTTGC TC ATG ATT TTT GTC 114
Met Ile Phe Val
1AAT AAA TAT CTC TAT GGG ATT AAA AGC GTT GTG CCT TTG GCG GTT GGT 162Asn Lys Tyr Leu Tyr Gly Ile Lys Ser Val Val Pro Leu Ala Val Gly 5 10 15 20TTT AGC AAA TAC CCT TTA AAA AAG TTT TTA TGG CTT AAT GTT TTT TCC 210Phe Ser Lys Tyr Pro Leu Lys Lys Phe Leu Trp Leu Asn Val Phe Ser
25 30 35AGT TTT TTG TGG GCG CTC ATC GTG GGG AGC GTT TCT TTT CAA GCG AGC 258Ser Phe Leu Trp Ala Leu Ile Val Gly Ser Val Ser Phe Gln Ala Ser
40 45 50GAT TGG GTG AAA ACG CTG TAT GAA AGG CTT TCT CAT TAC ACT TCG TTT 306Asp Trp Val Lys Thr Leu Tyr Glu Arg Leu Ser His Tyr Thr Ser Phe
55 60 65TTT ATC ATA AGT TTT GTT CTT ATA GCG CTT TTA ATA TGG TTT TTA TTG 354Phe Ile Ile Ser Phe Val Leu Ile Ala Leu Leu Ile Trp Phe Leu Leu
70 75 80AAA CGA TAT TCG CGC AAA ATG GGT TTT TAAGCAAGAT GTTTAATTAA ATGCGCT 408Lys Arg Tyr Ser Arg Lys Met Gly Phe85 90AGACTACGCC CACAAGCATT CGC 431
(2) Sequence 72 data:
(i) sequence characteristics:
(A) length: 93 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 72: met Ile Phe Val Asn Lys Tyr Leu Tyr Gly Ile Lys Ser Val Val Pro 151015 Leu Ala Val Gly Phe Ser Lys Tyr Pro Leu Lys Lys Phe Leu Trp Leu
20 25 30Asn Val Phe Ser Ser Phe Leu Trp Ala Leu Ile Val Gly Ser Val Ser
35 40 45Phe Gln Ala Ser Asp Trp Val Lys Thr Leu Tyr Glu Arg Leu Ser His
50 55 60Tyr Thr Ser Phe Phe Ile Ile Ser Phe Val Leu Ile Ala Leu Leu Ile65 70 75 80Trp Phe Leu Leu Lys Arg Tyr Ser Arg Lys Met Gly Phe
85 90
(2) Sequence 73 data:
(i) sequence characteristics:
(A) length: 1281bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...1227
(D) Other information:
(xi) Description of the sequence: sequence 73: TAGCATCAAT ACCCCTTAAA TAAAAGATAT AATGCTGTAT TATAAGCTAG TTTTAATTAC 60AATTTTCAA ATG TTA AGG AAA AAC ATT TTA GCT TAC TAT GGG GCG AAT TTT 111
Met Leu Arg Lys Asn Ile Leu Ala Tyr Tyr Gly Ala Asn Phe
1 5 10CTC TTA ATC ATC GCT CAA AGC TTA CCC CAT GCG ATT TTA ACC CCC TTG 159Leu Leu Ile Ile Ala Gln Ser Leu Pro His Ala Ile Leu Thr Pro Leu15 20 25 30TTG CTT TCT AAA GGG CTT AGT TTG AGT GAA ATC TTG CTC GTG CAA ACC 207Leu Leu Ser Lys Gly Leu Ser Leu Ser Glu Ile Leu Leu Val Gln Thr
35 40 45TTT TTT AGC TTT TGC GTG CTA GTG GCT GAA TAC CCA AGC GGC GTT TTA 255Phe Phe Ser Phe Cys Val Leu Val Ala Glu Tyr Pro Ser Gly Val Leu
50 55 60GCG GAT TTG ATG AGC CGA AAA AAT TTA TTC CTG GTT TCT AAT GCC TTT 303Ala Asp Leu Met Ser Arg Lys Asn Leu Phe Leu Val Ser Asn Ala Phe
65 70 75TTA ATC GCT AGT TTT TCG TTT GTG CTG TTT TTT GAT AGC TTT ATT TTC 351Leu Ile Ala Ser Phe Ser Phe Val Leu Phe Phe Asp Ser Phe Ile Phe
80 85 90ATG CTT TTA GCG TGG GGG TTG TAT GGT TTG TAT AGC GCA TGC TCT AGC 399Met Leu Leu Ala Trp Gly Leu Tyr Gly Leu Tyr Ser Ala Cys Ser Ser95 100 105 110GGC ACG ATT GAA GCT TCA CTC ATC ACA GAC ATT AAG GAA AAC AAA AAA 447Gly Thr Ile Glu Ala Ser Leu Ile Thr Asp Ile Lys Glu Asn Lys Lys
115 120 125GAT TTA TCC AAG TTT TTA GCC AAA AAC AAT CAA ATT ACT TAT TTA GGC 495Asp Leu Ser Lys Phe Leu Ala Lys Asn Asn Gln Ile Thr Tyr Leu Gly
130 135 140ATG ATT ATA GGG AGT TCT TTG GGA TCG TTT TTG TAT CTC AAA GTC CAT 543Met Ile Ile Gly Ser Ser Leu Gly Ser Phe Leu Tyr Leu Lys Val His
145 150 155GCG ATG CTG TAT ATT GTG GGG ATT TTT TTA ATC ATG CTC TGT GTG CTA 591Ala Met Leu Tyr Ile Val Gly Ile Phe Leu Ile Met Leu Cys Val Leu
160 165 170ACG ATC ATT TTT TAT TTT AAA GAG AAA GAA GGG GAT TTT AAA AGC CAA 639Thr Ile Ile Phe Tyr Phe Lys Glu Lys Glu Gly Asp Phe Lys Ser Gln175 180 185 190AAA AGC CTG AAA CTC CTT AAA GAG CAA GTC AAA GGC AGT CTT AAA GAG 687Lys Ser Leu Lys Leu Leu Lys Glu Gln Val Lys Gly Ser Leu LysGlu
195 200 205CTT AAA GAT AAC CCC AAA CTT AAA ATT CTG TTA GTG GGG CAT TTG ATT 735Leu Lys Asp Asn Pro Lys Leu Lys Ile Leu Leu Val Gly His Leu Ile
210 215 220ACG CCC GTC TTT TTT ATG AGC CAT TTT CAA ATG TGG CAA GCG TAT TTT 783Thr Pro Val Phe Phe Met Ser His Phe Gln Met Trp Gln Ala Tyr Phe
225 230 235TTA AAA CAA GGC GTT AAA GAG CAA TAC CTT TTT GTG TTT TAT ATC GCT 831Leu Lys Gln Gly Val Lys Glu Gln Tyr Leu Phe Val Phe Tyr Ile Ala
240 245 250TTT CAA GTG ATT TCT ATT CTC ATT CAT TTT TTA AAA GCC TCT AGT TAT 879Phe Gln Val Ile Ser Ile Leu Ile His Phe Leu Lys Ala Ser Ser Tyr255 260 265 270AGC CAA AAA ATC GCC TTG AGT TCG CTT GTG GTG TTG TTA GGC GTT AGC 927Ser Gln Lys Ile Ala Leu Ser Ser Leu Val Val Leu Leu Gly Val Ser
275 280 285CCC TTA TTG CTT AGC AAT ATC CCT TAT TGT TTC ATA GGG GTG TAT GCG 975Pro Leu Leu Leu Ser Asn Ile Pro Tyr Cys Phe Ile Gly Val Tyr Ala
290 295 300CTC ATG GTG GCG TTT TTC ACT TAC ATG AGC TAT TGC TTA AAC TAT CAA 1023Leu Met Val Ala Phe Phe Thr Tyr Met Ser Tyr Cys Leu Asn Tyr Gln
305 310 315TTC TCC AAA TTC GTT TCT AAA AAC AAC ATT TCC TCG CTC TCA TCG CTT 1071Phe Ser Lys Phe Val Ser Lys Asn Asn Ile Ser Ser Leu Ser Ser Leu
320 325 330TTA TCA AGC TGT GTG CGC GTG GTC TCT GTG CTA ATC TTA TCG CTC ACC 1119Leu Ser Ser Cys Val Arg Val Val Ser Val Leu Ile Leu Ser Leu Ser335 340 345 350AGT CTG GAA CTG CGT TAC TTC TCA CCC CTA ACT ATC ATA ACC ATG CAT 1167Ser Leu Glu Leu Arg Tyr Phe Ser Pro Leu Thr Ile Ile Thr Met His
355 360 365TTT GCC TTG ACG CTT ATC ATC CTC TTT TTC TTT TTG TAT AAG GCT AAG 1215Phe Ala Leu Thr Leu Ile Ile Leu Phe Phe Phe Leu Tyr Lys Ala Lys
370 375 380CCG TTT GAT GAG TGAGCGGCTT TAAGAGTGCA ACCTTTTAGC GATTTCTATA GCAAC 1272Pro Phe Asp Glu
385ATCATAGCC 1281
(2) Sequence 74 data:
(i) sequence characteristics:
(A) length: 386 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 74: met Leu Arg Lys Asn Ile Leu Ala Tyr Tyr Gly Ala Asn Phe Leu Leu 151015 Ile Ile Ala Gln Ser Leu Pro His Ala Ile Leu Thr Pro Leu Leu Leu
20 25 30Ser Lys Gly Leu Ser Leu Ser Glu Ile Leu Leu Val Gln Thr Phe Phe
35 40 45Ser Phe Cys Val Leu Val Ala Glu Tyr Pro Ser Gly Val Leu Ala Asp
50 55 60Leu Met Ser Arg Lys Asn Leu Phe Leu Val Ser Asn Ala Phe Leu Ile65 70 75 80Ala Ser Phe Ser Phe Val Leu Phe Phe Asp Ser Phe Ile Phe Met Leu
85 9095Leu Ala Trp Gly Leu Tyr Gly Leu Tyr Ser Ala Cys Ser Ser Gly Thr
100 105 110Ile Glu Ala Ser Leu Ile Thr Asp Ile Lys Glu Asn Lys Lys Asp Leu
115 120 125Ser Lys Phe Leu Ala Lys Asn Asn Gln Ile Thr Tyr Leu Gly Met Ile
130 135 140Ile Gly Ser Ser Leu Gly Ser Phe Leu Tyr Leu Lys Val His Ala Met145 150 155 150Leu Tyr Ile Val Gly Ile Phe Leu Ile Met Leu Cys Val Leu Thr Ile
165 170 175Ile Phe Tyr Phe Lys Glu Lys Glu Gly Asp Phe Lys Sar Gln Lys Ser
180 185 190Leu Lys Leu Leu Lys Glu Gln Val Lys Gly Ser Leu Lys Glu Leu Lys
195 200 205Asp Asn Pro Lys Leu Lys Ile Leu Leu Val Gly His Leu Ile Thr Pro
210 215 220Val Phe Phe Met Ser His Phe Gln Met Trp Gln Ala Tyr Phe Leu Lys225 230 235 240Gln Gly Val Lys Glu Gln Tyr Leu Phe Val Phe Tyr Ile Ala Phe Gln
245 250 255Val Ile Ser Ile Leu Ile His Phe Leu Lys Ala Ser Ser Tyr Ser Gln
260 265 270Lys Ile Ala Leu Ser Ser Leu Val Val Leu Leu Gly Val Ser Pro Leu
275 280 285Leu Leu Ser Asn Ile Pro Tyr Cys Phe Ile Gly Val Tyr Ala Leu Met
290 295 300Val Ala Phe Phe Thr Tyr Met Ser Tyr Cys Leu Asn Tyr Gln Phe Ser305 310 315 320Lys Phe Val Ser Lys Asn Asn Ile Ser Ser Leu Ser Ser Leu Leu Ser
325 330 335Ser Cys Val Arg Val Val Ser Val Leu Ile Leu Ser Leu Ser Ser Leu
340 345 350Glu Leu Arg Tyr Phe Ser Pro Leu Thr Ile Ile Thr Met His Phe Ala
355 360 365Leu Thr Leu Ile Ile Leu Phe Phe Phe Leu Tyr Lys Ala Lys Pro Phe
370 375 380Asp Glu385
(2) Sequence 75 data:
(i) sequence characteristics:
(A) length: 2218bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 77...2167
(D) Other information:
(xi) Description of the sequence: sequence 75: GAAGTTTATG AGCCGTTTTG CCACTATTCA AAGAAATTTT GGATTATAAT AAAAAAACTG 60GCTGAAATTA ACAACA ATG ATT AAA CAA TCA TTA AAT GGA GAG GAC ATG CAA 112
Met Ile Lys Gln Ser Leu Asn Gly Glu Asp Met Gln
1 5 10AAA AGT TTA GTT TCT TTG GCT TGG GTT TTT GTA GCT ATT TTA GGG GCG 160Lys Ser Leu Val Ser Leu Ala Trp Val Phe Val Ala Ile Leu Gly Ala
15 20 25ATC TGT TTA GGG GTG TTA GCC TTA CAC AAG GGT GAG AGC ATT AAC ACG 208Ile Cys Leu Gly Val Leu Ala Leu His Lys Gly Glu Ser Ile Asn Thr
30 35 40CTA TGG CTT GTA GTA GCG AGC GCT TGT ATT TAT AGC ATA GGC TAT CGT 256Leu Trp Leu Val Val Ala Ser Ala Cys Ile Tyr Ser Ile Gly Tyr Arg45 50 55 60TTT TAT AGC CAT TTT ATC GCT TAT AAG GTG TTA AAG CTA GAT GAT AGC 304Phe Tyr Ser His Phe Ile Ala Tyr Lys Val Leu Lys Leu Asp Asp Ser
65 70 75AGA GCC ACG CCC GCA TGC GTA AGG AAT GAT GGC AAG GAT TTT GTG CCA 352Arg Ala Thr Pro Ala Cys Val Arg Asn Asp Gly Lys Asp Phe Val Pro
80 85 90ACC GAT AAA GCG ATC ACT TTT GGG CAC CAT TTC GCC GCT ATT GCT GGG 400Thr Asp Lys Ala Ile Thr Phe Gly His His Phe Ala Ala Ile Ala Gly
95 100 105GCT GGC CCT TTA GTA GGC CCG ATA CrA GCC GCT CAA ATG GGT TAC TTG 448Ala Gly Pro Leu Val Gly Pro Ile Leu Ala Ala Gln Met Gly Tyr Leu
110 115 120CCC TCT ATC TTA TGG ATT TTG ATA GGC TCG GTT TTA GGG GGT TGC GTG 496Pro Ser Ile Leu Trp Ile Leu Ile Gly Ser Val Leu Gly Gly Cys Val125 130 135 140CAT GAT TTT GTG GTG CTT TTT GCT TCT ATT AGG CGC GAT GGC AAG TCT 544His Asp Phe Val Val Leu Phe Ala Ser Ile Arg Arg Asp Gly Lys Ser
145 150 155TTA GGC GAA ATG ATC AAA CTT GAA ATG GGC CAA TTT GTA GGC ATG ATC 592Leu Gly Glu Met Ile Lys Leu Glu Met Gly Gln Phe Val Gly Met Ile
160 165 170GCA AGT CTG GGC ATT TTA GGG ATC ATG CTC ATT ATC ATT GCG ATT TTA 640Ala Ser Leu Gly Ile Leu Gly Ile Met Leu Ile Ile Ile Ala Ile Leu
175 180 185GCG ATG GTG GTG GTG AAG GCT TTA GCG CAT TCG CCT TGG GGC TTT TTT 688Ala Met Val Val Val Lys Ala Leu Ala His Ser Pro Trp Gly Phe Phe
190 195 200ACG ATC GCA ATG ACT ATT CCC ATT GCG ATT CTT ATG GGG CTT TAC ATG 736Thr Ile Ala Met Thr Ile Pro Ile Ala Ile Leu Met Gly Leu Tyr Met205 210 215 220CGG TTT TTC AGG CCA CAC AAG ATT TTA GAG GTT TCT GTT ATT GGC TTT 784Arg Phe Phe Arg Pro His Lys Ile Leu Glu Val Ser Val Ile Gly Phe
225 230 235ATC CTA TTG ATT ATA GCG ATT TAT GCG GGT AAA TAC GTT TCT TTA GAT 832Ile Leu Leu Ile Ile Ala Ile Tyr Ala Gly Lys Tyr Val Ser Leu Asp
240 245 250CCT AAA TTA GCG TCA ATA TTC ACT TTT GAG GCC AGT TCT TTA GCG TGG 880Pro Lys Leu Ala Ser Ile Phe Thr Phe Glu Ala Ser Ser Leu Ala Trp
255 260 265ATG ATC ATG GGC TAT GGG TTT GTG GCT TCT ATT TTA CCG GTA TGG TTT 928Met Ile Met Gly Tyr Gly Phe Val Ala Ser Ile Leu Pro Val Trp Phe
270 275 280TTA CTC GCT CCA CGA GAT TAT CTA AGC ACT TTT TTA AAA ATT GGC GTT 976Leu Leu Ala Pro Arg Asp Tyr Leu Ser Thr Phe Leu Lys Ile Gly Val285 290 295 300ATA GGG GTG TTG GTT GTG GCC ATT ATT TTT GTC GCT CCG CCT TTA CAA 1024Ile Gly Val Leu Val Val Ala Ile Ile Phe Val Ala Pro Pro Leu Gln
305 310 315ATC CCT AAA ATC ACG CCC TTT GTA GAT GGC AGT GGG CCT GTG TTT GCA 1072Ile Pro Lys Ile Thr Pro Phe Val Asp Gly Ser Gly Pro Val Phe Ala
320 325 330GGA AGC GTG TTC CCT TTC TTG TTT ATC ACG GTG GCT TGC GGG ACG ATT 1120Gly Ser Val Phe Pro Phe Leu Phe Ile Thr Val Ala Cys Gly ThrIle
335 340 345AGC GGA TTC CAT GCT TTA ATT TCT TCA GGC ACG ACC CCT AAA ATG CTC 1168Ser Gly Phe His Ala Leu Ile Ser Ser Gly Thr Thr Pro Lys Met Leu
350 355 360GCT AAA GAA AGC GAC GCA AGG CTA GTG GGC TAT GGC TCT ATG GTG ATG 1216Ala Lys Glu Ser Asp Ala Arg Leu Val Gly Tyr Gly Ser Met Val Met365 370 375 380GAG AGC GTT GTG GCT CTT ATG GCG TTG GTG TGC GCA GGG ATC TTG CAC 1264Glu Ser Val Val Ala Leu Met Ala Leu Val Cys Ala Gly Ile Leu His
385 390 395CCA GGG CTT TAT TTC GCT ATC AAT TCG CCA GAA GTG AGC ATC GGT AAA 1312Pro Gly Leu Tyr Phe Ala Ile Asn Ser Pro Glu Val Ser Ile Gly Lys
400 405 410GAT ATA GCT GAT GCG GCT TCA GTG ATT AGC TCA TGG GGG TTT AAT ATC 1360Asp Ile Ala Asp Ala Ala Ser Val Ile Ser Ser Trp Gly Phe Asn Ile
415 420 425AGC GCT GAA GAA ATT CGT GAG ATG ACT AAA AAC ATC GGC GAA AGC TCC 1408Ser Ala Glu Glu Ile Arg Glu Met Thr Lys Asn Ile Gly Glu Ser Ser
430 435 440ATT TTG AGC CGC ACC GGT GGG GCG CCC ACT TTT GCG ATC GGT TTA GCG 1456Ile Leu Ser Arg Thr Gly Gly Ala Pro Thr Phe Ala Ile Gly Leu Ala445 450 455 460ATG ATT GTG TAT CAC ATT TTA GGG GAT CCA AGC GTG ATG GCG TTT TGG 1504Met Ile Val Tyr His Ile Leu Gly Asp Pro Ser Val Met Ala Phe Trp
465 470 475TAT CAT TTT GCG ATT TTG TTT GAA GCT TTG TTC ATT TTA ACC GCT GTG 1552Tyr His Phe Ala Ile Leu Phe Glu Ala Leu Phe Ile Leu Thr Ala Val
480 485 490GAT GCTGGC ACA CGA ACC GCT CGT TTC ATG ATT CAA GAT TTG CTC GGT 1600Asp Ala Gly Thr Arg Thr Ala Arg Phe Met Ile Gln Asp Leu Leu Gly
495 500 505AAT GTT TAT AAG CCT TTG GGC GAT CTT AGC TCT TAT AAG GCT GGG ATT 1648Asn Val Tyr Lys Pro Leu Gly Asp Leu Ser Ser Tyr Lys Ala Gly Ile
510 515 520TTT GCC ACT CTT TTG TGC GTG GCA GGG TGG GGG TAT TTC TTG TAT CAA 1696Phe Ala Thr Leu Leu Cys Val Ala Gly Trp Gly Tyr Phe Leu Tyr Gln525 530 535 540GGC ACG ATT GAT CCT AAA GGG GGG ATT TAT ACG CTA TGG CCT TTA TTT 1744Gly Thr Ile Asp Pro Lys Gly Gly Ile Tyr Thr Leu Trp Pro Leu Phe
545 550 555GGC GTG AGC AAT CAG ATG TTA GCG GGC ATG GCG TTG TTG TTG GTC ACG 1792Gly Val Ser Asn Gln Met Leu Ala Gly Met Ala Leu Leu Leu Val Thr
560 565 570GTG GTG TTG TTT AAA ATG GGG CGT TTT AAG GGG GCG ATG ATA AGC GCC 1840Val Val Leu Phe Lys Met Gly Arg Phe Lys Gly Ala Met Ile Ser Ala
575 580 585TTA CCG GCA GTT TTG ATT TTA TCC ATC ACT TTT TAT AGC GGT ATT TTA 1888Leu Pro Ala Val Leu Ile Leu Ser Ile Thr Phe Tyr Ser Gly Ile Leu
590 595 600AAG GTG GTG CCA AAG AGC GAT AAC AGC GTG CTG AAT AAT GTT TCC CAT 1936Lys Val Val Pro Lys Ser Asp Asn Ser Val Leu Asn Asn Val Ser His605 610 615 620GTG GCG CAA ATG CAA ATC ATC AAA GAA AAA ATG GCT ACC ACT ACC GAT 1984Val Ala Gln Met Gln Ile Ile Lys Glu Lys Met Ala Thr Thr Thr Asp
625 630 635GAA AAA GCG CTC AAA ACG CTC CAA AAA TCC TTT TTT AAC CAC GCT ATT 2032Glu Lys Ala Leu Lys Thr Leu Gln LysSer Phe Phe Asn His Ala Ile
640 645 650GAT GCG ATT TTG TGC GTG TTT TTC ATG CTT GTG GCG CTA TTG GTT TTA 2080Asp Ala Ile Leu Cys Val Phe Phe Met Leu Val Ala Leu Leu Val Leu
655 660 665ATC GTG AGC GTT AGG ATT TGC TCA AAC GCT TAT TTT AAA AAC AAA ATT 2128Ile Val Ser Val Arg Ile Cys Ser Asn Ala Tyr Phe Lys Asn Lys Ile
670 675 680TAC CCA CCG CTG GCT GAA ACG CCC TAC ATC AAA GCC TCT TGAATAAAAA AG 2179Tyr Pro Pro Leu Ala Glu Thr Pro Tyr Ile Lys Ala Ser685 690 695GGGTTTTAAC CCCCTTTAAA TCCATAGAAA AAAGTTTGA 2218
(2) Sequence 76 data:
(i) sequence characteristics:
(A) length: 697 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 76: met Ile Lys Gln Ser Leu Asn Gly Glu Asp Met Gln Lys Ser Leu Val 151015 Ser Leu Ala Trp Val Phe Val Ala Ile Leu Gly Ala Ile Cys Leu Gly
20 25 30Val Leu Ala Leu His Lys Gly Glu Ser Ile Asn Thr Leu Trp Leu Val
35 40 45Val Ala Ser Ala Cys Ile Tyr Ser Ile Gly Tyr Arg Phe Tyr Ser His
50 55 60Phe Ile Ala Tyr Lys Val Leu Lys Leu Asp Asp Ser Arg Ala Thr Pro65 70 75 80Ala Cys Val Arg Asn Asp Gly Lys Asp Phe Val ProThr Asp Lys Ala
85 90 95Ile Thr Phe Gly His His Phe Ala Ala Ile Ala Gly Ala Gly Pro Leu
100 105 110Val Gly Pro Ile Leu Ala Ala Gln Met Gly Tyr Leu Pro Ser Ile Leu
115 120 125Trp Ile Leu Ile Gly Ser Val Leu Gly Gly Cys Val His Asp Phe Val
130 135 140Val Leu Phe Ala Ser Ile Arg Arg Asp Gly Lys Ser Leu Gly Glu Met145 150 155 160Ile Lys Leu Glu Met Gly Gln Phe Val Gly Met Ile Ala Ser Leu Gly
165 170 175Ile Leu Gly Ile Met Leu Ile Ile Ile Ala Ile Leu Ala Met Val Val
180 185 190Val Lys Ala Leu Ala His Ser Pro Trp Gly Phe Phe Thr Ile Ala Met
195 200 205Thr Ile Pro Ile Ala Ile Leu Met Gly Leu Tyr Met Arg Phe Phe Arg
210 215 220Pro His Lys Ile Leu Glu Val Ser Val Ile Gly Phe Ile Leu Leu Ile225 230 235 240Ile Ala Ile Tyr Ala Gly Lys Tyr Val Ser Leu Asp Pro Lys Leu Ala
245 250 255Ser Ile Phe Thr Phe Glu Ala Ser Ser Leu Ala Trp Met Ile Met Gly
260 265 270Tyr Gly Phe Val Ala Ser Ile Leu Pro Val Trp Phe Leu Leu Ala Pro
275 280 285Arg Asp Tyr Leu Ser Thr Phe Leu Lys Ile Gly Val Ile Gly Val Leu
290 295 300Val Val Ala Ile Ile Phe Val Ala ProPro Leu Gln Ile Pro Lys Ile305 310 315 320Thr Pro Phe Val Asp Gly Ser Gly Pro Val Phe Ala Gly Ser Val Phe
325 330 335Pro Phe Leu Phe Ile Thr Val Ala Cys Gly Thr Ile Ser Gly Phe His
340 345 350Ala Leu Ile Ser Ser Gly Thr Thr Pro Lys Met Leu Ala Lys Glu Ser
355 360 365Asp Ala Arg Leu Val Gly Tyr Gly Ser Met Val Met Glu Ser Val Val
370 375 380Ala Leu Met Ala Leu Val Cys Ala Gly Ile Leu His Pro Gly Leu Tyr385 390 395 400Phe Ala Ile Asn Ser Pro Glu Val Ser Ile Gly Lys Asp Ile Ala Asp
405 410 415Ala Ala Ser Val Ile Ser Ser Trp Gly Phe Asn Ile Ser Ala Glu Glu
420 425 430Ile Arg Glu Met Thr Lys Asn Ile Gly Glu Ser Ser Ile Leu Ser Arg
435 440 445Thr Gly Gly Ala Pro Thr Phe Ala Ile Gly Leu Ala Met Ile Val Tyr
450 455 460His Ile Leu Gly Asp Pro Ser Val Met Ala Phe Trp Tyr His Phe Ala465 470 475 480Ile Leu Phe Glu Ala Leu Phe Ile Leu Thr Ala Val Asp Ala Gly Thr
485 490 495Arg Thr Ala Arg Phe Met Ile Gln Asp Leu Leu Gly Asn Val Tyr Lys
500 505 510Pro Leu Gly Asp Leu Ser Ser Tyr Lys Ala Gly Ile Phe Ala Thr Leu
515 520 525Leu Cys Val Ala Gly Trp Gly Tyr Phe LeuTyr Gln Gly Thr Ile Asp
530 535 540Pro Lys Gly Gly Ile Tyr Thr Leu Trp Pro Leu Phe Gly Val Ser Asn545 550 555 560Gln Met Leu Ala Gly Met Ala Leu Leu Leu Val Thr Val Val Leu Phe
565 570 575Lys Met Gly Arg Phe Lys Gly Ala Met Ile Ser Ala Leu Pro Ala Val
580 585 590Leu Ile Leu Ser Ile Thr Phe Tyr Ser Gly Ile Leu Lys Val Val Pro
595 600 605Lys Ser Asp Asn Ser Val Leu Asn Asn Val Ser His Val Ala Gln Met
610 615 620Gln Ile Ile Lys Glu Lys Met Ala Thr Thr Thr Asp Glu Lys Ala Leu625 630 635 640Lys Thr Leu Gln Lys Ser Phe Phe Asn His Ala Ile Asp Ala Ile Leu
645 650 655Cys Val Phe Phe Met Leu Val Ala Leu Leu Val Leu Ile Val Ser Val
660 665 670Arg Ile Cys Ser Asn Ala Tyr Phe Lys Asn Lys Ile Tyr Pro Pro Leu
675 680 685Ala Glu Thr Pro Tyr Ile Lys Ala Ser
690 695
(2) Sequence 77 data:
(i) sequence characteristics:
(A) length: 911bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 121...861
(D) Other information:
(xi) Description of the sequence: sequence 77: TAAGGGGCTT TGCATTTTTT ACTCATTTCA TGCCTCTTTT TCTTTATTTA GACAGATTAT 60TATCTTAAAA TAATTGTAAT ATCATTATTA TTATATCAAC TCAATAAAAA AGGAGAAGGT 120 ATG CAA AAA ACT TCT AAC ACT CTG GCG CTG GGG AGT TTG ACA GCG CTA 168 Met Gln Lys Thr Ser Asn Thr Leu Ala Leu Gly Ser Leu Thr Ala Leu 151015 TTC TTT CTA ATG GGT TTT ATC ACG GTT TTA AAC GAT ATT TTA ATC CCA 216Phe Phe Leu Met Gly Phe Ile Thr Val Leu Asn Asp Ile Leu Ile Pro
20 25 30CAC TTA AAG CCC ATT TTT GAC TTG ACC TAT TTT GAA GCT TCA CTC ATT 264His Leu Lys Pro Ile Phe Asp Leu Thr Tyr Phe Glu Ala Ser Leu Ile
35 40 45CAA TTT TGC TTT TTT GGG GCG TAT TTC ATC ATG GGA GGA GTT TTT GGG 312Gln Phe Cys Phe Phe Gly Ala Tyr Phe Ile Met Gly Gly Val Phe Gly
50 55 60AAT GTG ATC AGT AAA ATC GGC TAC CCT TTT GGC GTG GTG CTT GGT TTT 360Asn Val Ile Ser Lys Ile Gly Tyr Pro Phe Gly Val Val Leu Gly Phe65 70 75 80GTG ATC ACA GCG ACG GGG TGC GCG TTG TTT TAT CCG GCG GCG CAT TTT 408Val Ile Thr Ala Thr Gly Cys Ala Leu Phe Tyr Pro Ala Ala His Phe
85 90 95GGA TCC TAT GGG TTT TTT TTA GGA GCG TTG TTT ATT TTA GCG AGC GGG 456Gly Ser Tyr Gly Phe Phe Leu Gly Ala Leu Phe Ile Leu Ala Ser Gly
100 105 110ATT GTG TGC TTG CAA ACC GCT GGT AAT CCC TTT GTA ACC TTG CTT TCT 504Ile Val Cys Leu Gln Thr Ala Gly Asn Pro Phe Val Thr Leu Leu Ser
115 120 125AAA GGT AAA GAAGCC AGA AAT TTG GTT TTA GTC CAG GCG TTC AAT TCG 552Lys Gly Lys Glu Ala Arg Asn Leu Val Leu Val Gln Ala Phe Asn Ser
130 135 140CTT GGC ACA ACT TTA GGG CCT ATT TTT GGG AGC TTG TTG ATT TTT AGC 600Leu Gly Thr Thr Leu Gly Pro Ile Phe Gly Ser Leu Leu Ile Phe Ser145 150 155 160ACG ACT AAA ATG GGC GAT AAT GCA AGT TTG ATA GAT AAA TTA GCG GAC 648Thr Thr Lys Met Gly Asp Asn Ala Ser Leu Ile Asp Lys Leu Ala Asp
165 170 175GCT AAA AGC GTT CAA ATG CCT TAT TTG GGC TTG GCG GTG TTT TCG CTT 696Ala Lys Ser Val Gln Met Pro Tyr Leu Gly Leu Ala Val Phe Ser Leu
180 185 190CTT TTA GCG CTC ATC ATG TAT CTT TTG AAA TTG CCT GAT GTG GAA AAA 744Leu Leu Ala Leu Ile Met Tyr Leu Leu Lys Leu Pro Asp Val Glu Lys
195 200 205GAA ATG CCC AAA GAG ACG ACT CAA AAA AGC TTG TTT TCG CAC AAA CAC 792Glu Met Pro Lys Glu Thr Thr Gln Lys Ser Leu Phe Ser His Lys His
210 215 220TTT GTT TTT GGG GCT TGG GGA TCT TTT TTT ATG TGG GGG GAG AAN TGG 840Phe Val Phe Gly Ala Trp Gly Ser Phe Phe Met Trp Gly Glu Xaa Trp225 230 235 240CGA TTG GCT CAT TCT TGG TGC TAAGCTTTGA AAAGCTTTTG AATTTAGACT CTCA 895Arg Leu Ala His Ser Trp Cys
245ATCAAGCGCG CATTAC 911
(2) Sequence 78 data:
(i) sequence characteristics:
(A) length: 247 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 78: met Gln Lys Thr Ser Asn Thr Leu Ala Leu Gly Ser Leu Thr Ala Leu 151015 Phe Phe Leu Met Gly Phe Ile Thr Val Leu Asn Asp Ile Leu Ile Pro
20 25 30His Leu Lys Pro Ile Phe Asp Leu Thr Tyr Phe Glu Ala Ser Leu Ile
35 40 45Gln Phe Cys Phe Phe Gly Ala Tyr Phe Ile Met Gly Gly Val Phe Gly
50 55 60Asn Val Ile Ser Lys Ile Gly Tyr Pro Phe Gly Val Val Leu Gly Phe65 70 75 80Val Ile Thr Ala Thr Gly Cys Ala Leu Phe Tyr Pro Ala Ala His Phe
85 90 95Gly Ser Tyr Gly Phe Phe Leu Gly Ala Leu Phe Ile Leu Ala Ser Gly
100 105 110Ile Val Cys Leu Gln Thr Ala Gly Asn Pro Phe Val Thr Leu Leu Ser
115 120 125Lys Gly Lys Glu Ala Arg Asn Leu Val Leu Val Gln Ala Phe Asn Ser
130 135 140Leu Gly Thr Thr Leu Gly Pro Ile Phe Gly Ser Leu Leu Ile Phe Ser145 150 155 160Thr Thr Lys Met Gly Asp Asn Ala Ser Leu Ile Asp Lys Leu Ala Asp
165 170 175Ala Lys Ser Val Gln Met Pro Tyr Leu Gly Leu Ala Val Phe Ser Leu
180 185 190Leu Leu Ala Leu Ile Met Tyr Leu Leu Lys Leu Pro Asp Val Glu Lys
195200 205Glu Met Pro Lys Glu Thr Thr Gln Lys Ser Leu Phe Ser His Lys His
210 215 220Phe Val Phe Gly Ala Trp Gly Ser Phe Phe Met Trp Gly Glu Xaa Trp225 230 235 240Arg Leu Ala His Ser Trp Cys
245
(2) Data in SEQ ID NO:
(i) sequence characteristics:
(A) length: 3084bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...3027
(D) Other information:
(xi) Description of the sequence: sequence 79: GAATTAATGC ATTAAATAAC TCAAAATTTT TGATCAAAGG CTTGAAAT ATG TCA AAA 57
Met Ser Lys
1AAA ATT CCC CTA AAA AAC CGC TTG AGA GCT GAT TTT ACA AAA ACC CCA 105Lys Ile Pro Leu Lys Asn Arg Leu Arg Ala Asp Phe Thr Lys Thr Pro
5 10 15ACA GAT TTA GAA GTC CCT AAT TTA TTA TTA TTA CAA CGA GAC AGC TAT 153Thr Asp Leu Glu Val Pro Asn Leu Leu Leu Leu Gln Arg Asp Ser Tyr20 25 30 35GAT TCT TTC TTG TAT TCT AAA GAG GGT AAA GAG AGC GGG ATT GAA AAG 201Asp Ser Phe Leu Tyr Ser Lys Glu Gly Lys Glu Ser Gly Ile Glu Lys
40 4550GTT TTT AAA TCC ATT TTC CCT ATC CAA GAT GAG CAT AAC CGC ATC ACT 249Val Phe Lys Ser Ile Phe Pro Ile Gln Asp Glu His Asn Arg Ile Thr
55 60 65TTA GAA TAC GCG GGT TGC GAA TTT GGC AAG TCT AAA TAC ACC GTT AGA 297Leu Glu Tyr Ala Gly Cys Glu Phe Gly Lys Ser Lys Tyr Thr Val Arg
70 75 80GAA GCG ATG GAG AGG GGC ATT ACC TAC TCT ATC CCT CTC AAA ATT AAG 345Glu Ala Met Glu Arg Gly Ile Thr Tyr Ser Ile Pro Leu Lys Ile Lys
85 90 95GTG CGC TTG ATC TTG TGG GAA AAA GAT ACC AAG AGT GGC GAA AAG AAC 393Val Arg Leu Ile Leu Trp Glu Lys Asp Thr Lys Ser Gly Glu Lys Asn100 105 110 115GGC ATT AAG GAT ATT AAA GAA CAA AGC ATT TTC ATT CGT GAG ATC CCT 441Gly Ile Lys Asp Ile Lys Glu Gln Ser Ile Phe Ile Arg Glu Ile Pro
120 125 130TTG ATG ACA GAA CGC ACT TCA TTT ATT ATT AAT GGG GTG GAG CGC GTG 489Leu Met Thr Glu Arg Thr Ser Phe Ile Ile Asn Gly Val Glu Arg Val
135 140 145GTG GTC AAT CAA CTC CAC AGA AGC CCC GGT GTG ATT TTC AAA GAA GAA 537Val Val Asn Gln Leu His Arg Ser Pro Gly Val Ile Phe Lys Glu Glu
150 155 160GAG TCT AGC ACT TCT TTA AAC AAG CTC ATT TAC ACA GGG CAA ATC ATT 585Glu Ser Ser Thr Ser Leu Asn Lys Leu Ile Tyr Thr Gly Gln Ile Ile
165 170 175CCT GAT AGG GGT TCG TGG TTG TAT TTT GAA TAC GAT TCT AAA GAT GTT 633Pro Asp Arg Gly Ser Trp Leu Tyr Phe Glu Tyr Asp Ser Lys Asp Val180 185 190 195TTA TAC GCT CGT ATC AAT AAA CGC CGT AAA GTG CCT GTT ACC ATT TTA 681Leu Tyr Ala Arg Ile Asn Lys Arg Arg Lys Val Pro Val Thr Ile Leu
200 205 210TTC AGG GCG ATG GAT TAT CAA AAA CAA GAC ATC ATC AAA ATG TTC TAC 729Phe Arg Ala Met Asp Tyr Gln Lys Gln Asp Ile Ile Lys Met Phe Tyr
215 220 225CCG CTT GTT AAA GTG CGT TAT GAA AAC GAT AAA TAT TTG ATC CCG TTT 777Pro Leu Val Lys Val Arg Tyr Glu Asn Asp Lys Tyr Leu Ile Pro Phe
230 235 240GCT TCA TTA GAC GCC AAT CAA AGA ATG GAA TTT GAC TTG AAA GAT CCT 825Ala Ser Leu Asp Ala Asn Gln Arg Met Glu Phe Asp Leu Lys Asp Pro
245 250 255CAA GGC AAG GTT ATT CTT TTA GCG GGT AAA AAG CTC ACT TCA AGA AAG 873Gln Gly Lys Val Ile Leu Leu Ala Gly Lys Lys Leu Thr Ser Arg Lys260 265 270 275ATT AAA GAG CTT AAA GAA AAC CAT TTA GAA TGG GTG GAA TAC CCT ATG 921Ile Lys Glu Leu Lys Glu Asn His Leu Glu Trp Val Glu Tyr Pro Met
280 285 290GAT ATT TTA CTC AAT CGC CAT TTA GCT GAG CCT GTT ATG GTA GGG AAA 969Asp Ile Leu Leu Asn Arg His Leu Ala Glu Pro Val Met Val Gly Lys
295 300 305GAA GTC TTA TTG GAC ATG CTC ACT CAG CTA GAT AAA AAC AAA TTA GAA 1017Glu Val Leu Leu Asp Met Leu Thr Gln Leu Asp Lys Asn Lys Leu Glu
310 315 320AAA ATC CAC GAT TTA GGC GTG CAA GAA TTT GTG ATC ATC AAC GAT CTG 1065Lys Ile His Asp Leu Gly Val Gln Glu Phe Val Ile Ile Asn Asp Leu
325 330 335GCG TTA GGG CAT GAC GCT TCC ATT ATC CAA TCT TTT TCA GCC GAT TCT 1113Ala Leu Gly His Asp Ala Ser Ile Ile Gln Ser Phe Ser Ala Asp Ser340 345 350 355GAG TCT TTG AAA TTA CTC AAG CAA ACC GAA AAA ATT GAT GAT GAA AAC 1161Glu Ser Leu Lys Leu Leu Lys Gln Thr Glu Lys Ile Asp Asp Glu Asn
360 365 370GCT CTA GCG GCG ATT CGT ATC CAT AAG GTT ATG AAA CCA GGC GAT CCC 1209Ala Leu Ala Ala Ile Arg Ile His Lys Val Met Lys Pro Gly Asp Pro
375 380 385GTT ACG ACT GAA GTG GCT AAG CAG TTT GTC AAA AAA CTT TTC TTT GAT 1257Val Thr Thr Glu Val Ala Lys Gln Phe Val Lys Lys Leu Phe Phe Asp
390 395 400CCA GAA CGC TAT GAT TTG ACC ATG GTG GGC CGC ATG AAA ATG AAT CAC 1305Pro Glu Arg Tyr Asp Leu Thr Met Val Gly Arg Met Lys Met Asn His
405 410 415AAG TTA GGC TTG CAT GTG CCT GAT TAC ATT ACG ACT TTA ACG CAT GAA 1353Lys Leu Gly Leu His Val Pro Asp Tyr Ile Thr Thr Leu Thr His Glu420 425 430 435GAT ATT ATC ACC ACC GTT AAA TAC CTC ATG AAG ATC AAA AAC AAT CAA 1401Asp Ile Ile Thr Thr Val Lys Tyr Leu Met Lys Ile Lys Asn Asn Gln
440 445 450GGC AAG ATT GAT GAC AGG GAC CAC TTG GGC AAT CGT AGG ATT AGG GCG 1449Gly Lys Ile Asp Asp Arg Asp His Leu Gly Asn Arg Arg Ile Arg Ala
455 460 465GTA GGG GAA TTG TTG GCC AAT GAA TTG CAT TCA GGT TTA GTG AAA ATG 1497Val Gly Glu Leu Leu Ala Asn Glu Leu His Ser Gly Leu Val Lys Met
470 475 480CAA AAG ACC ATT AAA GAC AAG CTC ACT ACC ATG AGC GGG GCT TTT GAT 1545Gln Lys Thr Ile Lys Asp Lys Leu Thr Thr Met Ser Gly Ala Phe Asp
485 490 495TCG CTC ATG CCC CAT GAC TTG GTC AAT TCT AAA ATG ATC ACA AGC ACC 1593Ser Leu Met Pro His Asp Leu Val Asn Ser Lys Met Ile Thr Ser Thr500 505 510 515ATC ATG GAA TTT TTC ATG GGC GGT CAG CTC TCG CAA TTT ATG GAT CAA 1641Ile Met Glu Phe Phe Met Gly Gly Gln Leu Ser Gln Phe Met Asp Gln
520 525 530ACG AAT CCC TTG AGT GAG GTT ACG CAC AAG CGC CGC CTT TCA GCG CTC 1689Thr Asn Pro Leu Ser Glu Val Thr His Lys Arg Arg Leu Ser Ala Leu
535 540 545GGC GAA GGG GGG TTG GTG AAA GAC AGA GTG GGG TTT GAA GCC AGG GAT 1737Gly Glu Gly Gly Leu Val Lys Asp Arg Val Gly Phe Glu Ala Arg Asp
550 555 560GTG CAC CCC ACG CAT TAT GGC CGA ATT TGT CCC ATT GAG ACC CCA GAA 1785Val His Pro Thr His Tyr Gly Arg Ile Cys Pro Ile Glu Thr Pro Glu
565 570 575GGT CAA AAT ATC GGT CTG ATC AAC ACC CTT TCC ACT TTC ACA AGA GTG 1833Gly Gln Asn Ile Gly Leu Ile Asn Thr Leu Ser Thr Phe Thr Arg Val580 585 590 595AAT GAT TTA GGC TTT ATT GAA GCC CCT TAT AAA AAG GTT GTG GAT GGC 1881Asn Asp Leu Gly Phe Ile Glu Ala Pro Tyr Lys Lys Val Val Asp Gly
600 605 610AAG GTC GTG GGT GAG ACG ATT TAT TTG ACC GCT ATT CAA GAA GAC AGC 1929Lys Val Val Gly Glu Thr Ile Tyr Leu Thr Ala Ile Gln Glu Asp Ser
615 620 625CAC ATC ATC GCT CCC GCA AGC ACC CCC ATT GAT GAA GAG GGG AAT ATT 1977His Ile Ile Ala Pro Ala Ser Thr Pro Ile Asp Glu Glu Gly Asn Ile
630 635 640TTG GGC GAT TTG ATT GAA ACG CGC GTG GAA GGC GAG ATC GTT TTA AAC 2025Leu Gly Asp Leu Ile Glu Thr Arg Val Glu Gly Glu Ile Val Leu Asn
645 650 655GAA AAA AGC AAA GTA ACC TTA ATG GAT TTA AGC TCT AGC ATG CTA GTG 2073Glu Lys Ser Lys Val Thr Leu Met Asp Leu Ser Ser Ser Met Leu Val660 665 670 675GGG GTA GCC GCA TCG CTC ATT CCT TTC TTA GAG CAT GAT GAC GCC AAC 2121Gly Val Ala Ala Ser Leu Ile Pro Phe Leu Glu His Asp Asp Ala Asn
680 685 690CGT GCC TTA ATG GGG ACT AAC ATG CAG CGC CAA GCG GTG CCC TTA TTA 2169Arg Ala Leu Met Gly Thr Asn Met Gln Arg Gln Ala Val Pro Leu Leu
695 700 705AGA AGC GAC GCT CCC ATT GTA GGC ACG GGG ATT GAA AAA ATT ATT GCT 2217Arg Ser Asp Ala Pro Ile Val Gly Thr Gly Ile Glu Lys Ile Ile Ala
710 715 720AGG GAT TCT TGG GGA GCG ATC AAA GCC AAT CGC GCA GGC GTT GTA GAA 2265Arg Asp Ser Trp Gly Ala Ile Lys Ala Asn Arg Ala Gly Val Val Glu
725 730 735AAA ATT GAT TCT AAA AAT ATT TAT ATT TTA GGC GAA AGC AAA GAA GAA 2313Lys Ile Asp Ser Lys Asn Ile Tyr Ile Leu Gly Glu Ser Lys Glu Glu740 745 750 755GCC TAT ATT GAT GCG TAT TCT TTG CAA AAA AAC TTG CGC ACC AAC CAA 2361Ala Tyr Ile Asp Ala Tyr Ser Leu Gln Lys Asn Leu Arg Thr Asn Gln
760 765 770AAC ACC AGT TTC AAT CAA GTC CCT ATC GTT AAA GTG GGC GAT AAA GTG 2409Asn Thr Ser Phe Asn Gln Val Pro Ile Val Lys Val Gly Asp Lys Val
775 780 785GGA GCC GGG CAA ATC ATC GCT GAT GGC CCT AGC ATG GAT AGA GGC GAG 2457Gly Ala Gly Gln Ile Ile Ala Asp Gly Pro Ser Met Asp Arg Gly Glu
790 795 800TTG GCG TTA GGG AAA AAT GTG CGC GTG GCG TTC ATG CCT TGG AAT GGC 2505Leu Ala Leu Gly Lys Asn Val Arg Val Ala Phe Met Pro Trp Asn Gly
805 810 815TAT AAC TTT GAA GAC GCG ATC GTG GTG AGT GAG TGC ATC ACT AAA GAT 2553Tyr Asn Phe Glu Asp Ala Ile Val Val Ser Glu Cys Ile Thr Lys Asp820 825 830 835GAT ATT TTC ACT TCC ACC CAC ATT TAT GAA AAA GAA GTG GAT GCT AGG 2601Asp Ile Phe Thr Ser Thr His Ile Tyr Glu Lys Glu Val Asp Ala Arg
840 845 850GAG CTT AAG CAT GGT GTG GAA GAA TTT ACC GCT GAT ATT CCT GAT GTG 2649Glu Leu Lys His Gly Val Glu Glu Phe Thr Ala Asp Ile Pro Asp Val
855 860 865AAA GAA GAA GCG CTC GCT CAT CTT GAT GAA AGC GGG ATC GTT AAA GTC 2697Lys Glu Glu Ala Leu Ala His Leu Asp Glu Ser Gly Ile Val Lys Val
870 875 880GGT ACT TAT GTG AGC GCT GGC ATG ATT TTG GTG GGC AAA ACT TCT CCT 2745Gly Thr Tyr Val Ser Ala Gly Met Ile Leu Val Gly Lys Thr Ser Pro
885 890 895AAA GGC GAG ATT AAA AGC ACG CCT GAA GAG CGG CTT TTA AGG GCT ATT 2793Lys Gly Glu Ile Lys Ser Thr Pro Glu Glu Arg Leu Leu Arg Ala Ile900 905 910 915TTT GGG GAT AAA GCC GGG CAT GTG GTC AAT AAG AGT TTG TAT TGC CCT 2841Phe Gly Asp Lys Ala Gly His Val Val Asn Lys Ser Leu Tyr Cys Pro
920 925 930CCC AGT TTG GAA GGC ACG GTG ATT GAT GTG AAA GTC TTC ACT AAA AAA 2889Pro Ser Leu Glu Gly Thr Val Ile Asp Val Lys Val Phe Thr Lys Lys
935 940 945GGC TAT GAG AAA GAC GCG CGA GTT TTG AGC CGG TAT GAA GAA GAA AAA 2937Gly Tyr Glu Lys Asp Ala Arg Val Leu Ser Ala Tyr Glu Glu Glu Lys
950 955 960GCC AAG CTT GAT ATG GAG CAT TTT GAT CGC TTG ACC ATG CTC AAT AGA 2985Ala Lys Leu Asp Met Glu His Phe Asp Arg Leu Thr Met Leu Asn Arg
965 970 975GAA GAA TTG TTG CGC GTT ACT CGC TCC TTT CTC AAG CGA TTT TAGAAGAGC 3036Glu Glu Leu Leu Arg Val Thr Arg Ser Phe Leu Lys Arg Phe980 985 990CTTTCAGCCA TAACGGCAAG GATTATAAAG AAGGCGATCA AATCCCTA 3084
(2) Sequence 80 data:
(i) sequence characteristics:
(A) length: 993 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 80: met Ser Lys Lys Ile Pro Leu Lys Asn Arg Leu Arg Ala Asp Phe Thr 151015 Lys Thr Pro Thr Asp Leu Glu Val Pro Asn Leu Leu Leu Leu Gln Arg
20 25 30Asp Ser Tyr Asp Ser Phe Leu Tyr Ser Lys Glu Gly Lys Glu Ser Gly
35 40 45Ile Glu Lys Val Phe Lys Ser Ile Phe Pro Ile Gln Asp Glu His Asn
50 55 60Arg Ile Thr Leu Glu Tyr Ala Gly Cys Glu Phe Gly Lys Ser Lys Tyr65 70 75 80Thr Val Arg Glu Ala Met Glu Arg Gly Ile Thr Tyr Ser Ile Pro Leu
85 90 95Lys Ile Lys Val Arg Leu Ile Leu Trp Glu Lys Asp Thr Lys Ser Gly
l00105 110Glu Lys Asn Gly Ile Lys Asp Ile Lys Glu Gln Ser Ile Phe Ile Arg
115 120 125Glu Ile Pro Leu Met Thr Glu Arg Thr Ser Phe Ile Ile Asn Gly Val
130 135 140Glu Arg Val Val Val Asn Gln Leu His Arg Ser Pro Gly Val Ile Phe145 150 155 160Lys Glu Glu Glu Ser Ser Thr Ser Leu Asn Lys Leu Ile Tyr Thr Gly
165 170 175Gln Ile Ile Pro Asp Arg Gly Ser Trp Leu Tyr Phe Glu Tyr Asp Ser
180 185 190Lys Asp Val Leu Tyr Ala Arg Ile Asn Lys Arg Arg Lys Val Pro Val
195 200 205Thr Ile Leu Phe Arg Ala Met Asp Tyr Gln Lys Gln Asp Ile Ile Lys
210 215 220Met Phe Tyr Pro Leu Val Lys Val Arg Tyr Glu Asn Asp Lys Tyr Leu225 230 235 240Ile Pro Phe Ala Ser Leu Asp Ala Asn Gln Arg Met Glu Phe Asp Leu
245 250 255Lys Asp Pro Gln Gly Lys Val Ile Leu Leu Ala Gly Lys Lys Leu Thr
260 265 270Ser Arg Lys Ile Lys Glu Leu Lys Glu Asn His Leu Glu Trp Val Glu
275 280 285Tyr Pro Met Asp Ile Leu Leu Asn Arg His Leu Ala Glu Pro Val Met
290 295 300Val Gly Lys Glu Val Leu Leu Asp Met Leu Thr Gln Leu Asp Lys Asn305 310 315 320Lys Leu Glu Lys Ile His Asp Leu Gly Val Gln Glu Phe Val Ile Ile
325330 335Asn Asp Leu Ala Leu Gly His Asp Ala Ser Ile Ile Gln Ser Phe Ser
340 345 350Ala Asp Ser Glu Ser Leu Lys Leu Leu Lys Gln Thr Glu Lys Ile Asp
355 360 365Asp Glu Asn Ala Leu Ala Ala Ile Arg Ile His Lys Val Met Lys Pro
370 375 380Gly Asp Pro Val Thr Thr Glu Val Ala Lys Gln Phe Val Lys Lys Leu385 390 395 400Phe Phe Asp Pro Glu Arg Tyr Asp Leu Thr Met Val Gly Arg Met Lys
405 410 415Met Asn His Lys Leu Gly Leu His Val Pro Asp Tyr Ile Thr Thr Leu
420 425 430Thr His Glu Asp Ile Ile Thr Thr Val Lys Tyr Leu Met Lys Ile Lys
435 440 445Asn Asn Gln Gly Lys Ile Asp Asp Arg Asp His Leu Gly Asn Arg Arg
450 455 460Ile Arg Ala Val Gly Glu Leu Leu Ala Asn Glu Leu His Ser Gly Leu465 470 475 480Val Lys Met Gln Lys Thr Ile Lys Asp Lys Leu Thr Thr Met Ser Gly
485 490 495Ala Phe Asp Ser Leu Met Pro His Asp Leu Val Asn Ser Lys Met Ile
500 505 510Thr Ser Thr Ile Met Glu Phe Phe Met Gly Gly Gln Leu Ser Gln Phe
515 520 525Met Asp Gln Thr Asn Pro Leu Ser Glu Val Thr His Lys Arg Arg Leu
530 535 540Ser Ala Leu Gly Glu Gly Gly Leu Val Lys Asp Arg Val Gly Phe Glu545 550 555 560Ala Arg Asp Val HisPro Thr His Tyr Gly Arg Ile Cys Pro Ile Glu
565 570 575Thr Pro Glu Gly Gln Asn Ile Gly Leu Ile Asn Thr Leu Ser Thr Phe
580 585 590Thr Arg Val Asn Asp Leu Gly Phe Ile Glu Ala Pro Tyr Lys Lys Val
595 600 605Val Asp Gly Lys Val Val Gly Glu Thr Ile Tyr Leu Thr Ala Ile Gln610 615 620Glu Asp Ser His Ile Ile Ala Pro Ala Ser Thr Pro Ile Asp Glu Glu625 630 635 640Gly Asn Ile Leu Gly Asp Leu Ile Glu Thr Arg Val Glu Gly Glu Ile
645 650 655Val Leu Asn Glu Lys Ser Lys Val Thr Leu Met Asp Leu Ser Ser Ser
660 665 670Met Leu Val Gly Val Ala Ala Ser Leu Ile Pro Phe Leu Glu His Asp
675 680 685Asp Ala Asn Arg Ala Leu Met Gly Thr Asn Met Gln Arg Gln Ala Val
690 695 700Pro Leu Leu Arg Ser Asp Ala Pro Ile Val Gly Thr Gly Ile Glu Lys705 710 715 720Ile Ile Ala Arg Asp Ser Trp Gly Ala Ile Lys Ala Asn Arg Ala Gly
725 730 735Val Val Glu Lys Ile Asp Ser Lys Asn Ile Tyr Ile Leu Gly Glu Ser
740 745 750Lys Glu Glu Ala Tyr Ile Asp Ala Tyr Ser Leu Gln Lys Asn Leu Arg
755 760 765Thr Asn Gln Asn Thr Ser Phe Asn Gln Val Pro Ile Val Lys Val Gly
770 775 780Asp Lys Val Gly Ala Gly Gln Ile Ile Ala Asp Gly ProSer Met Asp785 790 795 800Arg Gly Glu Leu Ala Leu Gly Lys Asn Val Arg Val Ala Phe Met Pro
805 810 815Trp Asn Gly Tyr Asn Phe Glu Asp Ala Ile Val Val Ser Glu Cys Ile
820 825 830Thr Lys Asp Asp Ile Phe Thr Ser Thr His Ile Tyr Glu Lys Glu Val
835 840 845Asp Ala Arg Glu Leu Lys His Gly Val Glu Glu Phe Thr Ala Asp Ile
850 855 860Pro Asp Val Lys Glu Glu Ala Leu Ala His Leu Asp Glu Ser Gly Ile865 870 875 880Val Lys Val Gly Thr Tyr Val Ser Ala Gly Met Ile Leu Val Gly Lys
885 890 895Thr Ser Pro Lys Gly Glu Ile Lys Ser Thr Pro Glu Glu Arg Leu Leu
900 905 910Arg Ala Ile Phe Gly Asp Lys Ala Gly His Val Val Asn Lys Ser Leu
915 920 925Tyr Cys Pro Pro Ser Leu Glu Gly Thr Val Ile Asp Val Lys Val Phe
930 935 940Thr Lys Lys Gly Tyr Glu Lys Asp Ala Arg Val Leu Ser Ala Tyr Glu945 950 955 960Glu Glu Lys Ala Lys Leu Asp Met Glu His Phe Asp Arg Leu Thr Met
965 970 975Leu Asn Arg Glu Glu Leu Leu Arg Val Thr Arg Ser Phe Leu Lys Arg
980 985 990Phe
(2) Sequence 81 data:
(i) sequence characteristics:
(A) length: 581bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...525
(D) Other information:
(xi) Description of the sequence: sequence 81: AGGTTAAAGT TTAAGACAAA CCAAAGAGTT TGTCTTGTTT GTTTTTGA ATG CAC TCT 57
Met His Ser
1CCA AAT TTA GAA AAA GAA GAA ACC GAA ATC ATA GAA ACA CTC CTT ATG 105Pro Asn Leu Glu Lys Glu Glu Thr Glu Ile Ile Glu Thr Leu Leu Met
5 10 15CGT GAA AAA ATG CGT TTA TGC CCC TTG TAT TGG CGC ATC TTA GCG TTT 153Arg Glu Lys Met Arg Leu Cys Pro Leu Tyr Trp Arg Ile Leu Ala Phe20 25 30 35TTA ACC GAT GGT TTG TTA GTG GCG TTT TTA TTG AGC GAT CTT TTA GAC 201Leu Thr Asp Gly Leu Leu Val Ala Phe Leu Leu Ser Asp Leu Leu Asp
40 45 50GCA TGC GAT TTC TTG CAT TCT TTA TAT TGG CTA GCT AAC CCT ATT TAT 249Ala Cys Asp Phe Leu His Ser Leu Tyr Trp Leu Ala Asn Pro Ile Tyr
55 60 65CAC AGC GCA TTT GTT GCG ATG GGT TTT ATC ATC TTG TAT GGC GTT TAT 297His Ser Ala Phe Val Ala Met Gly Phe Ile Ile Leu Tyr Gly Val Tyr
70 75 80GAA ATC TTT TTT GTG TGT TTG TGC AAG ATG AGC TTG GCT AAA CTG GTT 345Glu Ile Phe Phe Val Cys Leu Cys Lys Met Ser Leu Ala Lys Leu Val
85 90 95TTT AGG ATT AAG ATT ATT GAT ATT TAT TTG GCA GAT TGC CCC AGT AGG 393Phe Arg Ile Lys Ile Ile Asp Ile Tyr Leu Ala Asp Cys Pro Ser Arg100 105 110 115GCT ATT TTA TTG AAG CGT TTA GGG TTA AAG ATC GTG GTT TTT CTA TGC 441Ala Ile Leu Leu Lys Arg Leu Gly Leu Lys Ile Val Val Phe Leu Cys
120 125 130CCC TTT TTA TGG TTT GTT GCG TTT AAA AAC CCC TAT CAT AGG GCG TGG 489Pro Phe Leu Trp Phe Val Ala Phe Lys Asn Pro Tyr His Arg Ala Trp
135 140 145CAT GAA GAA AAA AGC AAA AGT CTT TTG GTA TTG TTT TAATCATGAT TTATTG 541His Glu Glu Lys Ser Lys Ser Leu Leu Val Leu Phe
150 155GTTGTATTTG GCGGTCTTTT TTTTGTTGAG CGCATTAGAC 581
(2) Sequence 82 data:
(i) sequence characteristics:
(A) length: 159 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 82: met His Ser Pro Asn Leu Glu Lys Glu Glu Thr Glu Ile Ile Glu Thr 151015 Leu Leu Met Arg Glu Lys Met Arg Leu Cys Pro Leu Tyr Trp Arg Ile
20 25 30Leu Ala Phe Leu Thr Asp Gly Leu Leu Val Ala Phe Leu Leu Ser Asp
35 40 45Leu Leu Asp Ala Cys Asp Phe Leu His Ser Leu Tyr Trp Leu Ala Asn
50 55 60Pro Ile Tyr His Ser Ala Phe Val Ala Met Gly Phe Ile Ile Leu Tyr65 70 75 80Gly Val Tyr Glu Ile Phe Phe Val Cys Leu Cys Lys Met Ser Leu Ala
85 90 95Lys Leu Val Phe Arg Ile Lys Ile Ile Asp Ile Tyr Leu Ala Asp Cys
100 105 110Pro Ser Arg Ala Ile Leu Leu Lys Arg Leu Gly Leu Lys Ile Val Val
115 120 125Phe Leu Cys Pro Phe Leu Trp Phe Val Ala Phe Lys Asn Pro Tyr His
130 135 140Arg Ala Trp His Glu Glu Lys Ser Lys Ser Leu Leu Val Leu Phe145 150 155
(2) Sequence 83 data:
(i) sequence characteristics:
(A) length: 901bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 67...852
(D) Other information:
(xi) Description of the sequence: sequence B3: GAATTTAAGC GGCAGAGGGG ATAAGGATTT AAGCACCGTT TATAACGCTT TAAAAGGAGG 60TTTAAA ATG AGG TAT CAA AAC ATG TTT GAA ACC TTA AAA AAA CAC GAA 108
Met Arg Tyr Gln Asn Met Phe Glu Thr Leu Lys Lys His Glu
1 5 10AAA ATG GCG TTT ATC CCG TTT GTA ACC TTG GGC GAT CCT AAT TAT GAA 156Lys Met Ala Phe Ile Pro Phe Val Thr Leu Gly Asp Pro Asn Tyr Glu15 20 25 30TTG AGT TTT GAA ATC ATT AAA ACC CTA ATT ATT AGC GGG GTG AGC GCT 204Leu Ser Phe Glu Ile Ile Lys Thr Leu Ile Ile Ser Gly Val Ser Ala
35 40 45TTA GAA TTG GGT CTT GCT TTT TCT GAT CCT GTG GCG GAT GGC ATT ACC 252Leu Glu Leu Gly Leu Ala Phe Ser Asp Pro Val Ala Asp Gly Ile Thr
50 55 60ATA CAA GCG AGC CAT TTA AGG GCG TTA AAA CAC GCT AGC ATG GCT AAA 300Ile Gln Ala Ser His Leu Arg Ala Leu Lys His Ala Ser Met Ala Lys
65 70 75AAT TTC CAG CTT TTA AAA AAG ATT AGA GAT TAC AAC CAC AAT ATT CCC 348Asn Phe Gln Leu Leu Lys Lys Ile Arg Asp Tyr Asn His Asn Ile Pro
80 85 90ATA GGG CTT TTA GCG TAT GCG AAT TTA ATT TTT TCT TAT GGC GTT GAT 396Ile Gly Leu Leu Ala Tyr Ala Asn Leu Ile Phe Ser Tyr Gly Val Asp95 100 105 110GGC TTT TAC GCT CAA GCT AAA GAA TGC GGT ATA GAT AGC GTT TTA ATA 444Gly Phe Tyr Ala Gln Ala Lys Glu Cys Gly Ile Asp Ser Val Leu Ile
115 120 125GCG GAC ATG CCC CTA ATA GAA AAA GAA TTA GTC ATC AAA TCC GCT CAA 492Ala Asp Met Pro Leu Ile Glu Lys Glu Leu Val Ile Lys Ser Ala Gln
130 135 140AAA CAC CAA ATC AAG CAA ATC TTT ATC GCC AGC CCC AAT GCG AGC AGT 540Lys His Gln Ile Lys Gln Ile Phe Ile Ala Ser Pro Asn Ala Ser Ser
145 150 155AAA GAT TTA GAA CAA GTC GCT ACG CAT TCG CAA GGC TAT ATC TAC GCT 588Lys Asp Leu Glu Gln Val Ala Thr His Ser Gln Gly Tyr Ile Tyr Ala
160 165170TTA GCC AGG AGT GGG GTT ACA GGG GCG AGC CGT ATT TTA GAG AAT GAT 636Leu Ala Arg Ser Gly Val Thr Gly Ala Ser Arg Ile Leu Glu Asn Asp175 180 185 190TCG AGT GCT ATT ATT AAA ACC TTA AAA GCT TTT AGC CCT ACC CCA GCC 684Ser Ser Ala Ile Ile Lys Thr Leu Lys Ala Phe Ser Pro Thr Pro Ala
195 200 205TTA CTG GGC TTT GGC ATT TCC AAA AAA GAA CAC ATC ACA AAC GCT AAA 732Leu Leu Gly Phe Gly Ile Ser Lys Lys Glu His Ile Thr Asn Ala Lys
210 215 220GGC ATG GGT GCT GAT GGC GTG ATT TGC GGA TCA GCG TTA GTC AAA ATC 780Gly Met Gly Ala Asp Gly Val Ile Cys Gly Ser Ala Leu Val Lys Ile
225 230 235ATA GAA GAA AAT TTA AAC AAT GAA AAC GCC ATG CTG GAA AAA ATT AAA 828Ile Glu Glu Asn Leu Asn Asn Glu Asn Ala Met Leu Glu Lys Ile Lys
240 245 250GGG TTT ATA GGA GGA ATG ATT TTT TAAGGCTTTT AGGCTTTGTT GCGTTAAAAA 882Gly Phe Ile Gly Gly Met Ile Phe255 260TTAAAGATCA CAGATTAAC 901
(2) Sequence 84 data:
(i) sequence characteristics:
(A) length: 262 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 84: met Arg Tyr Gln Asn Met Phe Glu Thr Leu Lys Lys His Glu Lys Met 151015 Ala Phe Ile Pro Phe Val Thr Leu Gly Asp Pro Asn Tyr Glu Leu Ser
20 25 30Phe Glu Ile Ile Lys Thr Leu Ile Ile Ser Gly Val Ser Ala Leu Glu
35 40 45Leu Gly Leu Ala Phe Ser Asp Pro Val Ala Asp Gly Ile Thr Ile Gln
50 55 60Ala Ser His Leu Arg Ala Leu Lys His Ala Ser Met Ala Lys Asn Phe65 70 75 80Gln Leu Leu Lys Lys Ile Arg Asp Tyr Asn His Asn Ile Pro Ile Gly
85 90 95Leu Leu Ala Tyr Ala Asn Leu Ile Phe Ser Tyr Gly Val Asp Gly Phe
100 105 110Tyr Ala Gln Ala Lys Glu Cys Gly Ile Asp Ser Val Leu Ile Ala Asp
115 120 125Met Pro Leu Ile Glu Lys Glu Leu Val Ile Lys Ser Ala Gln Lys His
130 135 140Gln Ile Lys Gln Ile Phe Ile Ala Ser Pro Asn Ala Ser Ser Lys Asp145 150 155 160Leu Glu Gln Val Ala Thr His Ser Gln Gly Tyr Ile Tyr Ala Leu Ala
165 170 175Arg Ser Gly Val Thr Gly Ala Ser Arg Ile Leu Glu Asn Asp Ser Ser
180 185 190Ala Ile Ile Lys Thr Leu Lys Ala Phe Ser Pro Thr Pro Ala Leu Leu
195 200 205Gly Phe Gly Ile Ser Lys Lys Glu His Ile Thr Asn Ala Lys Gly Met
210 215 220Gly Ala Asp Gly Val Ile Cys Gly Ser Ala Leu Val Lys Ile Ile Glu225 230 235 240Glu Asn Leu Asn Asn G1u Asn Ala Met Leu Glu Lys Ile Lys Gly Phe
245250 255Ile Gly Gly Met Ile Phe
260
(2) Sequence 85 data:
(i) sequence characteristics:
(A) length: 1081bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...954
(D) Other information:
(xi) Description of the sequence: sequence 85: AAGTAATGCC CCTGTTGTAT CAGCTTGATT TAAGAGGAAT AAGTTATT ATG AAT AAA 57
Met Asn Lys
1GCT ATT GCT AGT AAG ATA CTC ATC ACT TTG GGT TTT TTA TTT CTC TAC 105Ala Ile Ala Ser Lys Ile Leu Ile Thr Leu Gly Phe Leu Phe Leu Tyr
5 10 15AGA GTC TTA GCT TAT ATC CCC ATT CCT GGC GTA GAT TTA GCA GCG ATC 153Arg Val Leu Ala Tyr Ile Pro Ile Pro Gly Val Asp Leu Ala Ala Ile20 25 30 35AAG GCT TTT TTT GAC AGC AAT TCC AAC AAC GCT TTG GGG TTG TTT AAT 201Lys Ala Phe Phe Asp Ser Asn Ser Asn Asn Ala Leu Gly Leu Phe Asn
40 45 50ATG TTT AGC GGG AAT GCG GTT TCT CGC TTG AGC ATC ATC TCG TTG GGT 249Met Phe Ser Gly Asn Ala Val Ser Arg Leu Ser Ile Ile Ser Leu Gly
55 60 65ATC ATG CCC TAT ATC ACT TCT TCA ATT ATC ATG GAG CTT TTG AGC GCG 297Ile Met Pro Tyr Ile Thr Ser Ser Ile Ile Met Glu Leu Leu Ser Ala
70 75 80ACT TTC CCT AAC CTG GCT AAA ATG AAA AAA GAG CGG GAT GGC ATG CAA 345Thr Phe Pro Asn Leu Ala Lys Met Lys Lys Glu Arg Asp Gly Met Gln
85 90 95AAA TAC ATG CAA ATC GTG CGT TAT TTG ACC ATT TTA ATC ACC CTA ATC 393Lys Tyr Met Gln Ile Val Arg Tyr Leu Thr Ile Leu Ile Thr Leu Ilel00 105 110 115CAA GCG GTG AGC GTT TCA GTA GGC TTA AGG AGC ATT AGT GGA GGA GCC 441Gln Ala Val Ser Val Ser Val Gly Leu Arg Ser Ile Ser Gly Gly Ala
120 125 130AAT GGG GCG ATC ATG ATT GAT ATG CAA GTT TTT ATG ATC GTT TCA GCG 489Asn Gly Ala Ile Met Ile Asp Met G1n Val Phe Met Ile Val Ser Ala
135 140 145TTT TCT ATG CTT ACA GGA ACG ATG CTA CTC ATG TGG ATA GGG GAG CAA 537Phe Ser Met Leu Thr Gly Thr Met Leu Leu Met Trp Ile Gly Glu Gln
150 155 160ATC ACG CAA AGG GGC GTG GGG AAT GGG ATC AGT CTC ATT ATT TTT GCC 585Ile Thr Gln Arg Gly Val Gly Asn Gly Ile Ser Leu Ile Ile Phe Ala
165 170 175GGG ATT GTT TCA GGG ATC CCA TCA GCT ATT TCA GGC ACA TTC AAT TTG 633Gly Ile Val Ser Gly Ile Pro Ser Ala Ile Ser Gly Thr Phe Asn Leu180 185 190 195GTC AAT ACG GGC GTT ATT AAT ATC TTA ATG CTC ATT GGT ATT GTG CTG 681Val Asn Thr Gly Val Ile Asn Ile Leu Met Leu Ile Gly Ile Val Leu
200 205 210ATT GTT TTA GCG ACT ATT TTT GCG ATT ATC TAT GTG GAA TTA GCT GAG 729Ile Val Leu Ala Thr Ile Phe Ala Ile Ile Tyr Val Glu Leu Ala Glu
215 220 225CGC AGG ATC CCT ATT TCT TAT GCG CGT AAA GTG GTG ATG CAA AAC CAA 777Arg Arg Ile Pro Ile Ser Tyr Ala Arg Lys Val Val Met Gln Asn Gln
230 235 240AAC AAG GGC ATC ATG AAT TAC ATT CCT ATT AAG TTG AAT TTA AGT GGG 825Asn Lys Arg Ile Met Asn Tyr Ile Pro Ile Lys Leu Asn Leu Ser Gly
245 250 255GTG ATC CCC CCT ATT TTC GCT TCA GCT TTG CTC GTG TTC CCT TCT ACG 873Val Ile Pro Pro Ile Phe Ala Ser Ala Leu Leu Val Phe Pro Ser Thr260 265 270 275ATT TTG CAG CAA GCC ACA AGC AAC AAA ACC TTG CAA GCG GTT GCG NAT 921Ile Leu Gln Gln Ala Thr Ser Asn Lys Thr Leu Gln Ala Val Ala Xaa
280 285 290TTT TTA AGC CCG CAA GGT ATG CGT ATA ATA TTT TGATGTTCTT GCTCATCATC 974Phe Leu Ser Pro Gln Gly Met Arg Ile Ile Phe
295 300TTTTTTGCTT ACTTTTATTC TTCTATTGTG TTCAATTCTA AGGATATTGC GGATAATTTG 1034AGGCGTAATG GCGGGTATAT TCCAGGGCTT AGGCCTGGAG AGGGGAC 1081
(2) Data for sequence 86:
(i) sequence characteristics:
(A) length: 302 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: and (3) sequence 86: met Asn Lys Ala Ile Ala Ser Lys Ile Leu Ile Thr Leu Gly Phe Leu 151015 Phe Leu Tyr Arg Val Leu Ala Tyr Ile Pro Ile Pro G1y Val Asp Leu
20 25 30Ala Ala Ile Lys Ala Phe Phe Asp Ser Asn Ser Asn Asn Ala Leu Gly
35 40 45Leu Phe Asn Met Phe Ser Gly Asn Ala Val Ser Arg Leu Ser Ile Ile
50 55 60Ser Leu Gly Ile Met Pro Tyr Ile Thr Ser Ser Ile Ile Met Glu Leu65 70 75 80Leu Ser Ala Thr Phe Pro Asn Leu Ala Lys Met Lys Lys Glu Arg Asp
85 90 95Gly Met Gln Lys Tyr Met Gln Ile Val Arg Tyr Leu Thr Ile Leu Ile
100 105 110Thr Leu Ile Gln Ala Val Ser Val Ser Val Gly Leu Arg Ser Ile Ser
115 120 125Gly Gly Ala Asn Gly Ala Ile Met Ile Asp Met Gln Val Phe Met Ile
130 135 140Val Ser Ala Phe Ser Met Leu Thr Gly Thr Met Leu Leu Met Trp Ile145 150 155 160Gly Glu Gln Ile Thr Gln Arg Gly Val Gly Asn Gly Ile Ser Leu Ile
165 170 175Ile Phe Ala Gly Ile Val Ser Gly Ile Pro Ser Ala Ile Ser Gly Thr
180 185 190Phe Asn Leu Val Asn Thr Gly Val Ile Asn Ile Leu Met Leu Ile Gly
195 200 205Ile Val Leu Ile Val Leu Ala Thr Ile Phe Ala Ile Ile Tyr Val Glu
210 215 220Leu Ala Glu Arg Arg Ile Pro Ile Ser Tyr Ala Arg Lys Val Val Met225 230 235 240Gln Asn Gln Asn Lys Arg Ile Met Asn Tyr Ile Pro Ile Lys Leu Asn
245 250255Leu Ser Gly Val Ile Pro Pro Ile Phe Ala Ser Ala Leu Leu Val Phe
260 265 270Pro Ser Thr Ile Leu Gln Gln Ala Thr Ser Asn Lys Thr Leu Gln Ala
275 280 285Val Ala Xaa Phe Leu Ser Pro Gln Gly Met Arg Ile Ile Phe
290 295 300
(2) Data for sequence 87:
(i) sequence characteristics:
(A) length: 423bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 109...363
(D) Other information:
(xi) Description of the sequence: sequence 87: AATGGGGCAA TTCAAGGCGA TAGAAGCTTG AATGAGGGGCT TCTTCTAAGG TTTTGGCTTT 60GATTTCAATA AAATTTTGCA TCAATGTTCC TTTTTGTTTT GCGCATGC ATG CGT TTT 117
Met Arg Phe
1TTA TTC TCT AAG ACT TTA TTG ATG ATG AGT TGT TGC AAC ACC GAA AGG 165Leu Phe Ser Lys Thr Leu Leu Met Met Ser Cys Cys Asn Thr Glu Arg
5 10 15ATG TTG TTC GTG GTC CAA TAC AAG ACT AAC CCT GCC GGG AAA GTG ATT 213Met Leu Phe Val Val Gln Tyr Lys Thr Asn Pro Ala Gly Lys Val Ile20 25 30 35AAA AAG ATT GTG AAT AAT AGG GGT AAG AGT TTA AAA ATC TTT GCT TGC261Lys Lys Ile Val Asn Asn Arg Gly Lys Ser Leu Lys Ile Phe Ala Cys
40 45 50ATG GGA TCG GTC ATG GTG TTT GGC GTA ACG CTT TGG TGC CAA TAC ATA 309Met Gly Ser Val Met Val Phe Gly Val Thr Leu Trp Cys Gln Tyr Ile
55 60 65GAC GCT CCC ATA AGA AGC GGT AAA ATA AAA TAC GGA TCC ATG ATG GAT 357Asp Ala Pro Ile Arg Ser Gly Lys Ile Lys Tyr Gly Ser Met Met Asp
70 75 80AAA TCA TGAATCCATA AGATCCACTC TGAGCTTTTC AATTCCACAG CGTTATAAAG CA 415Lys Ser
85CTCTATAA 423
(2) Data for sequence 88:
(i) sequence characteristics:
(A) length: 85 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: and (6) sequence 88: met Arg Phe Leu Phe Ser Lys Thr Leu Leu Met Met Ser Cys Cys Asn 151015 Thr Glu Arg Met Leu Phe Val Val Gln Tyr Lys Thr Asn Pro Ala Gly
20 25 30Lys Val Ile Lys Lys Ile Val Asn Asn Arg Gly Lys Ser Leu Lys Ile
35 40 45Phe Ala Cys Met Gly Ser Val Met Val Phe Gly Val Thr Leu Trp Cys
50 55 60Gln Tyr Ile Asp Ala Pro Ile Arg Ser Gly Lys Ile Lys Tyr Gly Ser65 70 75 80Met Met Asp Lys Ser
85
(2) Sequence 89 data:
(i) sequence characteristics:
(A) length: 740bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 59...688
(D) Other information:
(xi) Description of the sequence: sequence 89: TTTAAAATTA GAAACAGATG TATCTGTTTT AAATTTTGAA TAGGGAGTTT CTATCATT 58ATG TTA TTG AAA ACA AAA TTA AAA ATT ATA AGC TCG GTG ATT TTG AGC 106Met Leu Leu Lys Thr Lys Leu Lys Ile Ile Ser Ser Val Ile Leu Ser 151015 GCT TTA TTG TGG GTG GGT TGC TCA AGC GAA ATG GCA ACT TAT CAA AAC 154Ala Leu Leu Trp Val Gly Cys Ser Ser Glu Met Ala Thr Tyr Gln Asn
20 25 30GTG AAT GAT GCC ACT AAA AAT ACG ACT GCA AGC ATT AAT AGC ACG GAT 202Val Asn Asp Ala Thr Lys Asn Thr Thr Ala Ser Ile Asn Ser Thr Asp
35 40 45TTA TTG CTA ACC GCT AAC GCG ATG TTA GAT TCC ATG TTT AGC GAC CCT 250Leu Leu Leu Thr Ala Asn Ala Met Leu Asp Ser Met Phe Ser Asp Pro
50 55 60AAT TTT GAG CAA CTC AAG GGC AAG CAT TTG ATT GAA GTT TCA GAT GTG 298Asn Phe Glu Gln Leu Lys Gly Lys His Leu Ile Glu Val Ser Asp Val65 70 75 80ATT AAC GAC ACC ACG CAG CCC AAT TTG GAC ATG AAT CTT TTG ACG ACT 346Ile Asn Asp Thr Thr Gln Pro Asn Leu Asp Met Asn Leu Leu Thr Thr
85 90 95GAA ATC GCG CGG CAG TTG CGG TTG CGA TCT AAT GGG AGG TTC AAT ATC 394Glu Ile Ala Arg Gln Leu Arg Leu Arg Ser Asn Gly Arg Phe Asn Ile
100 105 110ACA AGG GCG AGC GGA GGG AGT GGC ATT GCA GCC GAT AGC AGA ATG GTG 442Thr Arg Ala Ser Gly Gly Ser Gly Ile Ala Ala Asp Ser Arg Met Val
115 120 125AAA CAG CGC GAA AAA GAA CGA GAG AGC GAA GAG TAT AAT CAA GAC ACC 490Lys Gln Arg Glu Lys Glu Arg Glu Ser Glu Glu Tyr Asn Gln Asp Thr
130 135 140ACT GTA GAA AAA GGC ACT TTA AAA GCC GCT GAT TTA TCT TTA AGT GGT 538Thr Val Glu Lys Gly Thr Leu Lys Ala Ala Asp Leu Ser Leu Ser Gly145 150 155 160AAA GTA TCT AGT ATC GCA GCC TCT ATT AGT AGT TCT AGG CAG CGC TTG 586Lys Val Ser Ser Ile Ala Ala Ser Ile Ser Ser Ser Arg Gln Arg Leu
165 170 175GAC TAT GAC TTC ACC CTA AGC CTT ACC AAC AGG AAA ACG GGT GAA GAG 634Asp Tyr Asp Phe Thr Leu Ser Leu Thr Asn Arg Lys Thr Gly Glu Glu
180 185 190GTA TGG AGC GAT GTT AAG CCT ATT GTG AAG AAC GCT AGC AAT AAG CGT 682Val Trp Ser Asp Val Lys Pro Ile Val Lys Asn Ala Ser Asn Lys Arg
195 200 205ATG TTT TAAATTTATA TTTGAAAGGA TGAACAATGA AAAATCAAGT TAAAAAAATT TT 740Met Phe
210
(2) Sequence 90 data:
(i) sequence characteristics:
(A) length: 210 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 90: met Leu Leu Lys Thr Lys Leu Lys Ile Ile Ser Ser Val Ile Leu Ser 151015 Ala Leu Leu Trp Val Gly Cys Ser Ser Glu Met Ala Thr Tyr Gln Asn
20 25 30Val Asn Asp Ala Thr Lys Asn Thr Thr Ala Ser Ile Asn Ser Thr Asp
35 40 45Leu Leu Leu Thr Ala Asn Ala Met Leu Asp Ser Met Phe Ser Asp Pro
50 55 60Asn Phe Glu Gln Leu Lys Gly Lys His Leu Ile Glu Val Ser Asp Val65 70 75 80Ile Asn Asp Thr Thr Gln Pro Asn Leu Asp Met Asn Leu Leu Thr Thr
85 90 95Glu Ile Ala Arg Gln Leu Arg Leu Arg Ser Asn Gly Arg Phe Asn Ile
100 105 110Thr Arg Ala Ser Gly Gly Ser Gly Ile Ala Ala Asp Ser Arg Met Val
115 120 125Lys Gln Arg Glu Lys Glu Arg Glu Ser Glu Glu Tyr Asn Gln Asp Thr
130 135 140Thr Val Glu Lys Gly Thr Leu Lys Ala Ala Asp Leu Ser Leu Ser Gly145 150 155 160Lys Val Ser Ser Ile Ala Ala Ser Ile Ser Ser Ser Arg Gln Arg Leu
165 170 175Asp Tyr Asp Phe Thr Leu Ser Leu Thr Asn Arg Lys Thr Gly Glu Glu
180 185 190Val Trp Ser Asp Val Lys Pro Ile Val Lys Asn Ala Ser Asn Lys Arg
195 200 205Met Phe
210
(2) Sequence 91 data:
(i) sequence characteristics:
(A) length: 1269bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 84...1214
(D) Other information:
(xi) Description of the sequence: sequence 91: TTATCATTGT GTTAAAATAG TCGTTTTAAC AAACAAAATT TTGTTAATAG ATTTTACCTA 60ATCTGAGAGA GAATTATATT TTA ATG AAG ACA GAG AAA CAA AAA TTT TTA GAG 113
Met Lys Thr Glu Lys Gln Lys Phe Leu Glu
1 5 10ATG CGT AAA GAT GGG GCG AAC TCT GTG CTG ATT TTA AGA GGG GAT TGG 161Met Arg Lys Asp Gly Ala Asn Ser Val Leu Ile Leu Arg Gly Asp Trp
15 20 25GAT TTT AAA ACG AGC GTG TTT CGT TTA GAT GAG TTG AAA AAA AAT TTA 209Asp Phe Lys Thr Ser Val Phe Arg Leu Asp Glu Leu Lys Lys Asn Leu
30 35 40TTA GAT CAT CAA GGG CCT TTA AAA ATG GAT TTT TCA GGG TGC CAA AAA 257Leu Asp His Gln Gly Pro Leu Lys Met Asp Phe Ser Gly Cys Gln Lys
45 50 55GTG GAT TTT GTT TTT GGC ATG TTT TTA TTT GAT TTA GTT AAG GAG CGT 305Val Asp Phe Val Phe Gly Met Phe Leu Phe Asp Leu Val Lys Glu Arg
60 65 70TCT TTA AAC ATT GAA TTG TGT AAC GTG AGT GAG AAT AAC GCA TGC GCT 353Ser Leu Asn Ile Glu Leu Cys Asn Val Ser Glu Asn Asn Ala Cys Ala75 80 85 90TTG AAA GTG GTT AAA GAC TGG CTT GAA AAA GAA GAG GAT TTA GAG TCT 401Leu Lys Val Val Lys Asp Trp Leu Glu Lys Glu Glu Asp Leu Glu Ser
95 100 105AAA AAA GCG GGC AAA CAC TAC GAA CTT TTG ATC ACT AAA TTG GGT AAG 449Lys Lys Ala Gly Lys His Tyr Glu Leu Leu Ile Thr Lys Leu Gly Lys
110 115 120AGT ATC GTA GAG ACT TAT AAT ACC TTT TTA AAC GCA TTC AAT TTT TGC 497Ser Ile Val Glu Thr Tyr Asn Thr Phe Leu Asn Ala Phe Asn Phe Cys
125 130 135GGC ATG ATT TTA TTC TAC TTC ATT AAA AGC GTT TTC AAC CCC AAA CGC 545Gly Met Ile Leu Phe Tyr Phe Ile Lys Ser Val Phe Asn Pro Lys Arg
140 145 150TTT TGT ATC ACT CCT TTG CTC TAT CAT ATC AAT GAA TCC GGG TTT AAG 593Phe Cys Ile Thr Pro Leu Leu Tyr His Ile Asn Glu Ser Gly Phe Lys155 160 165 170GTT TTG CCA GTG AGT ATT TTA ACG GTG TTT ATC GTG GGG TTT GCC GTT 641Val Leu Pro Val Ser Ile Leu Thr Val Phe Ile Val Gly Phe Ala Val
175 l80 185GCT TTA CAA GGG GCT TTA CAA TTA CAA GAC ATG GGC GCG CCT TTA ATG 689Ala Leu Gln Gly Ala Leu Gln Leu Gln Asp Met Gly Ala Pro Leu Met
190 195 200TCG GTG GAA ATG ACG GCT AAA CTC GCT TTA AGA GAA ATC GGC CCT TTT 737Ser Val Glu Met Thr Ala Lys Leu Ala Leu Arg Glu Ile Gly Pro Phe
205 210 215ATT TTA ACC CTT GTG GTG GCC GGG AGG AGC GCG AGC AGT TTT ACC GCG 785Ile Leu Thr Leu Val Val Ala Gly Arg Ser Ala Ser Ser Phe Thr Ala
220 225 230CAA ATT GGG GTG ATG AAG ATC ACT GAG GAA TTA GAC GCG ATG AAA ACC 833Gln Ile Gly Val Met Lys Ile Thr Glu Glu Leu Asp Ala Met Lys Thr235 240 245 250ATG GGC TTT AAC CCT TTT GAA TTT TTA GTG TTG CCT AGG GTG TTA GCC 881Met Gly Phe Asn Pro Phe Glu Phe Leu Val Leu Pro Arg Val Leu Ala
255 260 265TTA GTG ATT GTT TTG CCT TTA TTG GTG TTT ATT GCC GAT GCG TTC GCC 929Leu Val Ile Val Leu Pro Leu Leu Val Phe Ile Ala Asp Ala Phe Ala
270 275 280ATT CTT GGG GGC ATG TTT GCG ATT AAA TAC CAA TTG GAT TTA GGC TTC 977Ile Leu Gly Gly Met Phe Ala Ile Lys Tyr Gln Leu Asp Leu Gly Phe
285 290 295CCG AGC TAT ATT GAC AGA TTC CAT GAC ACA GTG GGT TGG AAC CAT TTT 1025Pro Ser Tyr Ile Asp Arg Phe His Asp Thr Val Gly Trp Asn His Phe
300 305 310TTG GTA GGG ATT GTC AAA GCC CCT TTT TGG GGG TTT GCG ATT GCG ATG 1073Leu Val Gly Ile Val Lys Ala Pro Phe Trp Gly Phe Ala Ile Ala Met315 320 325 330GTA GGG TGC ATG CGC GGG TTT GAA GTC AAG GGG GAT ACT GAG AGC ATT 1121Val Gly Cys Met Arg Gly Phe Glu Val Lys Gly Asp Thr Glu Ser Ile
335 340 345GGG CGC TTG ACC ACT ATT AGC GTC GTG AAC GCT TTG TTT TGG ATC ATT 1169Gly Arg Leu Thr Thr Ile Ser Val Val Asn Ala Leu Phe Trp Ile Ile
350 355 360TTC TTA GAC GCT ATT TTT TCT ATC ATC TTT TCT AAG TTG AAC ATA TAATG 1219Phe Leu Asp Ala Ile Phe Ser Ile Ile Phe Ser Lys Leu Asn Ile
365 370 375AACGCTACTA ACAATCAAGT CTTAATTGAA GTGAAGGATC TCCATAGCGC 1269
(2) Data for sequence 92:
(i) sequence characteristics:
(A) length: 377 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 92: met Lys Thr Glu Lys Gln Lys Phe Leu Glu Met Arg Lys Asp Gly Ala 151015 Asn Ser Val Leu Ile Leu Arg Gly Asp Trp Asp Phe Lys Thr Ser Val
20 25 30Phe Arg Leu Asp Glu Leu Lys Lys Asn Leu Leu Asp His Gln Gly Pro
35 40 45Leu Lys Met Asp Phe Ser Gly Cys Gln Lys Val Asp Phe Val Phe Gly
50 55 60Met Phe Leu Phe Asp Leu Val Lys Glu Arg Ser Leu Asn Ile Glu Leu65 70 75 80Cys Asn Val Ser Glu Asn Asn Ala Cys Ala Leu Lys Val Val Lys Asp
85 90 95Trp Leu Glu Lys Glu Glu Asp Leu Glu Ser Lys Lys Ala Gly Lys His
100 105 110Tyr Glu Leu Leu Ile Thr Lys Leu Gly Lys Ser Ile Val Glu Thr Tyr
115 120 125Asn Thr Phe Leu Asn Ala Phe Asn Phe Cys Gly Met Ile Leu Phe Tyr
130 135 140Phe Ile Lys Ser Val Phe Asn Pro Lys Arg Phe Cys Ile Thr Pro Leu145 150155 160Leu Tyr His Ile Asn Glu Ser Gly Phe Lys Val Leu Pro Val Ser Ile
165 170 175Leu Thr Val Phe Ile Val Gly Phe Ala Val Ala Leu Gln Gly Ala Leu
180 185 190Gln Leu Gln Asp Met Gly Ala Pro Leu Met Ser Val Glu Met Thr Ala
195 200 205Lys Leu Ala Leu Arg Glu Ile Gly Pro Phe Ile Leu Thr Leu Val Val
210 215 220Ala Gly Arg Ser Ala Ser Ser Phe Thr Ala Gln Ile Gly Val Met Lys225 230 235 240Ile Thr Glu Glu Leu Asp Ala Met Lys Thr Met Gly Phe Asn Pro Phe
245 250 255Glu Phe Leu Val Leu Pro Arg Val Leu Ala Leu Val Ile Val Leu Pro
260 265 270Leu Leu Val Phe Ile Ala Asp Ala Phe Ala Ile Leu Gly Gly Met Phe
275 280 285Ala Ile Lys Tyr Gln Leu Asp Leu Gly Phe Pro Ser Tyr Ile Asp Arg
290 295 300Phe His Asp Thr Val Gly Trp Asn His Phe Leu Val Gly Ile Val Lys305 310 315 320Ala Pro Phe Trp Gly Phe Ala Ile Ala Met Val Gly Cys Met Arg Gly
325 330 335Phe Glu Val Lys Gly Asp Thr Glu Ser Ile Gly Arg Leu Thr Thr Ile
340 345 350Ser Val Val Asn Ala Leu Phe Trp Ile Ile Phe Leu Asp Ala Ile Phe
355 360 365Ser Ile Ile Phe Ser Lys Leu Asn Ile
370375
(2) Sequence 93 data:
(i) sequence characteristics:
(A) length: 557bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 60...503
(D) Other information:
(xi) Description of the sequence: sequence 93: CACAAGAGAA AATTTGCAAG CGTTTTTACA ACAAAATAAG ATAAATTAGG GAGAGTGGT 59ATG GGA TTT TTG AAT GGG TAT TTT TTA TGG GTT AAG GCT TTC CAT GTG 107Met Gly Phe Leu Asn Gly Tyr Phe Leu Trp Val Lys Ala Phe His Val 151015 ATA GCG GTC ATT TCG TGG ATG GCA GCG TTG TTT TAT TTG CCG CGC CTT 155Ile Ala Val Ile Ser Trp Met Ala Ala Leu Phe Tyr Leu Pro Arg Leu
20 25 30TTT GTC TAT CAT GCA GAA AAC GCG CAT AAA AAA GAG TTT GTA GGA GTG 203Phe Val Tyr His Ala Glu Asn Ala His Lys Lys Glu Phe Val Gly Val
35 40 45GTT CAA ATC CAA GAA AAA AAG CTT TAT TCC TTT ATC GCT TCA CCG GCT 251Val Gln Ile Gln Glu Lys Lys Leu Tyr Ser Phe Ile Ala Ser Pro Ala
50 55 60ATG GGT TTT ACG CTT ATT ACA GGG ATT TTA ATG CTG TTG ATA GAG CCT 299Met Gly Phe Thr Leu Ile Thr Gly Ile Leu Met Leu Leu Ile Glu Pro65 70 75 80ACG CTC TTT AAA AGT GGG GGT TGG TTG CAT GCT AAA TTG GCT TTA GTG 347Thr Leu Phe Lys Ser Gly Gly Trp Leu His Ala Lys Leu Ala Leu Val
85 9095GTT TTA CTT TTA GCC TAT CAT TTT TAT TGC AAA AAA TGC ATG CGC GAG 395Val Leu Leu Leu Ala Tyr His Phe Tyr Cys Lys Lys Cys Met Arg Glu
100 105 110CTG GAA AAA GAC CCC ACA AGG AGA AAC GCA AGG TTT TAT CGC GTG TTT 443Leu Glu Lys Asp Pro Thr Arg Arg Asn Ala Arg Phe Tyr Arg Val Phe
115 120 125AAT GAG GCG CCA ACG ATT TTA ATG ATC CTC ATT GTG ATT TTA GTG GTT 491Asn Glu Ala Pro Thr Ile Leu Met Ile Leu Ile Val Ile Leu Val Val
130 135 140GTC AAG CCT TTT TAAAGACAAG CCATGAAAAA AGAAAAGTCA TGAAAAAAGA AAAGCA 549Val Lys Pro Phe145TCTCAAGC 557
(2) Data for sequence 94:
(i) sequence characteristics:
(A) length: 148 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 94: met Gly Phe Leu Asn Gly Tyr Phe Leu Trp Val Lys Ala Phe His Val 151015 Ile Ala Val Ile Ser Trp Met Ala Ala Leu Phe Tyr Leu Pro Arg Leu
20 25 30Phe Val Tyr His Ala Glu Asn Ala His Lys Lys Glu Phe Val Gly Val
35 40 45Val Gln Ile Gln Glu Lys Lys Leu Tyr Ser Phe Ile Ala Ser Pro Ala
50 55 60Met Gly Phe Thr Leu Ile Thr Gly Ile Leu Met Leu Leu Ile Glu Pro65 7075 80Thr Leu Phe Lys Ser Gly Gly Trp Leu His Ala Lys Leu Ala Leu Val
85 90 95Val Leu Leu Leu Ala Tyr His Phe Tyr Cys Lys Lys Cys Met Arg Glu
100 105 110Leu Glu Lys Asp Pro Thr Arg Arg Asn Ala Arg Phe Tyr Arg Val Phe
115 120 125Asn Glu Ala Pro Thr Ile Leu Met Ile Leu Ile Val Ile Leu Val Val
130 135 140Val Lys Pro Phe145
(2) Sequence 95 data:
(i) sequence characteristics:
(A) length: 1671bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...1624
(D) Other information:
(xi) Description of the sequence: sequence 95: CAAAATTATC TGGTGCTAAG ACTTTGAAAC AACGCCAAAT AACAACTGA ATG AAA CTT 58
Met Lys Leu
1TTT AAC GCT CGT TTA ATC GTT TTT ATT GGC GCG CTT CTT TTA GGG GTA 106Phe Asn Ala Arg Leu Ile Val Phe Ile Gly Ala Leu Leu Leu Gly Val
5 10 15GGG TTT TCT GTG CCT TCT TTA CTA GAA ACT AAA GGC CCT AAA ATC ACT 154Gly Phe Ser Val Pro Ser Leu Leu Glu Thr Lys Gly Pro Lys IleThr20 25 30 35TTA GGT TTG GAT TTA AGG GGG GGG TTG AAC ATG CTT TTA GGG GTA CAA 202Leu Gly Leu Asp Leu Arg Gly Gly Leu Asn Met Leu Leu Gly Val Gln
40 45 50ACC GAT GAG GCT TTA AAA AAC AAG TAT TTA AGC TTG GCG TCC GCT TTA 250Thr Asp Glu Ala Leu Lys Asn Lys Tyr Leu Ser Leu Ala Ser Ala Leu
55 60 65GAA TAC AAC GCT AAA AAG CAA AAT ATC TTG CTT AAA GAT ATT AAA TCC 298Glu Tyr Asn Ala Lys Lys Gln Asn Ile Leu Leu Lys Asp Ile Lys Ser
70 75 80AAT TTA GAA GGG ATC AGT TTT GAG CTT TTA GAT GAA GAT GAA GCG AAA 346Asn Leu Glu Gly Ile Ser Phe Glu Leu Leu Asp Glu Asp Glu Ala Lys
85 90 95AAA TTA GAC GCG CTT TTA TTG GAA TTG CAA GGC CAT AGC CAG TTT GAA 394Lys Leu Asp Ala Leu Leu Leu Glu Leu Gln Gly His Ser Gln Phe Glu100 105 110 115ATC AAA AAG GAA GCG GGG TTT TAT AGC GTG AAT CTC ACC CCT TTA GAG 442Ile Lys Lys Glu Ala Gly Phe Tyr Ser Val Asn Leu Thr Pro Leu Glu
120 125 130CAA GAA GAA TTG CGT AAA AAC ACG ATT TTG CAA GTG ATA GGG ATC ATT 490Gln Glu Glu Leu Arg Lys Asn Thr Ile Leu Gln Val Ile Gly Ile Ile
135 140 145CGT AAC CGC TTG GAT CAA TTT GGT TTG GCA GAG CCT GTA GTC ATT CAG 538Arg Asn Arg Leu Asp Gln Phe Gly Leu Ala Glu Pro Val Val Ile Gln
150 155 160CAA GGT AAA GAA GAA ATT TCG GTG CAA TTG CCT GGC ATT AAG ACT TTA 586Gln Gly Lys Glu Glu Ile Ser Val Gln Leu Pro Gly Ile Lys Thr Leu
165 170 175GAA GAA GAA CGGCGC GCT AAA GAC TTG ATT TCA AGA TCC GCT CAT TTG 634Glu Glu Glu Arg Arg Ala Lys Asp Leu Ile Ser Arg Ser Ala His Leu180 185 190 195CAG ATG ATG GCG GTG GAT GAA GAA CAC AAT AAA GAT GCG ATG AAA ATG 682Gln Met Met Ala Val Asp Glu Glu His Asn Lys Asp Ala Met Lys Met
200 205 210ACG GAT TTA GAG GCT CAA AAA TTA GGC AGC GTG TTG TTG TCT GAT GTG 730Thr Asp Leu Glu Ala Gln Lys Leu Gly Ser Val Leu Leu Ser Asp Val
215 220 225GAA ATG GGG GGT AAA ATC TTG CTC AAA GCG ATC CCC ATT TTA GAT GGC 778Glu Met Gly Gly Lys Ile Leu Leu Lys Ala Ile Pro Ile Leu Asp Gly
230 235 240GAA ATG CTT ACA GAT GCG AAA GTG GTG TAT GAC CAA AAC AAC CAG CCG 826Glu Met Leu Thr Asp Ala Lys Val Val Tyr Asp Gln Asn Asn Gln Pro
245 250 255GTG GTG AGC TTC ACG CTG GAT GCG CAA GGG GCT AAG ATT TTT GGG GAT 874Val Val Ser Phe Thr Leu Asp Ala Gln Gly Ala Lys Ile Phe Gly Asp260 265 270 275TTC TCA GGT GCG AAT GTG GGC AAA CGC ATG GCG ATT GTT TTA GAC AAT 922Phe Ser Gly Ala Asn Val Gly Lys Arg Met Ala Ile Val Leu Asp Asn
280 285 290AAG GTC TAT TCA GCC CCG GTG ATT AGG GAG CGT ATC GGT GGG GGG AGC 970Lys Val Tyr Ser Ala Pro Val Ile Arg Glu Arg Ile Gly Gly Gly Ser
295 300 305GGG CAG ATT AGC GGG AAT TTT AGC GTG GCT CAA GCG AGC GAT TTA GCG 1018Gly Gln Ile Ser Gly Asn Phe Ser Val Ala Gln Ala Ser Asp Leu Ala
310 315 320ATC GCT TTA AGG AGT GGG GCG ATG AGC GCT CCC ATT CAG GTT TTA GAA 1066Ile Ala Leu Arg Ser Gly Ala Met Ser Ala Pro Ile Gln Val Leu Glu
325 330 335AAA AGA ATT ATA GGC CCA AGT TTA GGG AAA GAC AGC GTT AAA ACT TCC 1114Lys Arg Ile Ile Gly Pro Ser Leu Gly Lys Asp Ser Val Lys Thr Ser340 345 350 355ATT ATC GCT CTA GTT GGG GGC TTT ATT TTA GTG ATG GGC TTT ATG GTG 1162Ile Ile Ala Leu Val Gly Gly Phe Ile Leu Val Met Gly Phe Met Val
360 365 370CTT TAT TAC TCT ATG GCG GGG GTG ATC GCT TGT TTG GCG TTA GTG GTC 1210Leu Tyr Tyr Ser Met Ala Gly Val Ile Ala Cys Leu Ala Leu Val Val
375 380 385AAT CTT TTT TTG ATT GTG GCG GTC ATG GCG ATT TTT GGA GCG ACG CTG 1258Asn Leu Phe Leu Ile Val Ala Val Met Ala Ile Phe Gly Ala Thr Leu
390 395 400ACT TTA CCG GGA ATG GCG GGG ATT GTT TTA ACC GTG GGG ATT GCC GTG 1306Thr Leu Pro Gly Met Ala Gly Ile Val Leu Thr Val Gly Ile Ala Val
405 410 415GAT GCT AAT ATC ATC ATC AAC GAG CGC ATT AGA GAA GTC TTA AGA GAG 1354Asp Ala Asn Ile Ile Ile Asn Glu Arg Ile Arg Glu Val Leu Arg Glu420 425 430 435AAT GAG GGC ATC GCT AAA GCG ATC CAT TTA GGC TAT ATC AAT GGG AGC 1402Asn Glu Gly Ile Ala Lys Ala Ile His Leu Gly Tyr Ile Asn Ala Ser
440 445 450CGG GCG ATT TTT GAT TCT AAT ATC ACT TCT TTG ATC GCT TCA GTG TTA 1450Arg Ala Ile Phe Asp Ser Asn Ile Thr Ser Leu Ile Ala Ser Val Leu
455 460 465TTA TAC GCT TAT GGC ACA GGA GCG ATT AAA GGC TTT GCC CTA ACT ACA 1498Leu Tyr Ala Tyr Gly Thr Gly Ala Ile Lys Gly Phe Ala Leu Thr Thr
470 475 480GGC ATT GGG ATT TTA GCC TCT ATT ATC ACC GCT ATT GTT GGC ACG CAA 1546Gly Ile Gly Ile Leu Ala Ser Ile Ile Thr Ala Ile Val Gly Thr Gln
485 490 495GGG ATT TAT CAA GCC CTT TTA CCT AAA CTC ACT CAA ACA AAA AGC CTT 1594Cly Ile Tyr Gln Ala Leu Leu Pro Lys Leu Thr Gln Thr Lys Ser Leu500 505 510 515TAC TTT TGG TTT GGC GTG AAT AAA AGA GCT TAGGAGGTTT TATGGAATTA TTC 1647Tyr Phe Trp Phe Gly Val Asn Lys Arg Ala
520 525AAACGAACTA GAATCTTAAG CTTC 1671
(2) Sequence 96 data:
(i) sequence characteristics:
(A) length: 525 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 96: met Lys Leu Phe Asn Ala Arg Leu Ile Val Phe Ile Gly Ala Leu Leu 151015 Leu Gly Val Gly Phe Ser Val Pro Ser Leu Leu Glu Thr Lys Gly Pro
20 25 30Lys Ile Thr Leu Gly Leu Asp Leu Arg Gly Gly Leu Asn Met Leu Leu
35 40 45Gly Val Gln Thr Asp Glu Ala Leu Lys Asn Lys Tyr Leu Ser Leu Ala
50 55 60Ser Ala Leu Glu Tyr Asn Ala Lys Lys Gln Asn Ile Leu Leu Lys Asp65 70 75 80Ile Lys Ser Asn Leu Glu Gly Ile Ser Phe Glu Leu Leu Asp Glu Asp
85 90 95GluAla Lys Lys Leu Asp Ala Leu Leu Leu Glu Leu Gln Gly His Ser
100 105 110Gln Phe Glu Ile Lys Lys Glu Ala Gly Phe Tyr Ser Val Asn Leu Thr
115 120 125Pro Leu Glu Gln Glu Glu Leu Arg Lys Asn Thr Ile Leu Gln Val Ile
130 135 140Gly Ile Ile Arg Asn Arg Leu Asp Gln Phe Gly Leu Ala Glu Pro Val145 150 155 160Val Ile Gln Gln Gly Lys Glu Glu Ile Ser Val Gln Leu Pro Gly Ile
165 170 175Lys Thr Leu Glu Glu Glu Arg Arg Ala Lys Asp Leu Ile Ser Arg Ser
180 185 190Ala His Leu Gln Met Met Ala Val Asp Glu Glu His Asn Lys Asp Ala
195 200 205Met Lys Met Thr Asp Leu Glu Ala Gln Lys Leu Gly Ser Val Leu Leu
210 215 220Ser Asp Val Glu Met Gly Gly Lys Ile Leu Leu Lys Ala Ile Pro Ile225 230 235 240Leu Asp Gly Glu Met Leu Thr Asp Ala Lys Val Val Tyr Asp Gln Asn
245 250 255Asn Gln Pro Val Val Ser Phe Thr Leu Asp Ala Gln Gly Ala Lys Ile
260 265 270Phe Gly Asp Phe Ser Gly Ala Asn Val Gly Lys Arg Met Ala Ile Val
275 280 285Leu Asp Asn Lys Val Tyr Ser Ala Pro Val Ile Arg Glu Arg Ile Gly
290 295 300Gly Gly Ser Gly Gln Ile Ser Gly Asn Phe Ser Val Ala Gln Ala Ser305 310 315 320Asp Leu Ala Ile Ala Leu ArgSer Gly Ala Met Ser Ala Pro Ile Gln
325 330 335Val Leu Glu Lys Arg Ile Ile Gly Pro Ser Leu Gly Lys Asp Ser Val
340 345 350Lys Thr Ser Ile Ile Ala Leu Val Gly Gly Phe Ile Leu Val Met Gly
355 360 365Phe Met Val Leu Tyr Tyr Ser Met Ala Gly Val Ile Ala Cys Leu Ala
370 375 380Leu Val Val Asn Leu Phe Leu Ile Val Ala Val Met Ala Ile Phe Gly385 390 395 400Ala Thr Leu Thr Leu Pro Gly Met Ala Gly Ile Val Leu Thr Val Gly
405 410 415Ile Ala Val Asp Ala Asn Ile Ile Ile Asn Glu Arg Ile Arg Glu Val
420 425 430Leu Arg Glu Asn Glu Gly Ile Ala Lys Ala Ile His Leu Gly Tyr Ile
435 440 445Asn Ala Ser Arg Ala Ile Phe Asp Ser Asn Ile Thr Ser Leu Ile Ala
450 455 460Ser Val Leu Leu Tyr Ala Tyr Gly Thr Gly Ala Ile Lys Gly Phe Ala465 470 475 480Leu Thr Thr Gly Ile Gly Ile Leu Ala Ser Ile Ile Thr Ala Ile Val
485 490 495Gly Thr Gln Gly Ile Tyr Gln Ala Leu Leu Pro Lys Leu Thr Gln Thr
500 505 510Lys Ser Leu Tyr Phe Trp Phe Gly Val Asn Lys Arg Ala
515 520 525
(2) Data for sequence 97:
(i) sequence characteristics:
(A) length: 706bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 64...654
(D) Other information:
(xi) Description of the sequence: sequence 97: CAGGGGGCAA GGGGGCTGTT AGGGAAGCGA TTGATTATCT TTTAACATTA GAAGGCTTGC 60AAG ATG AAG CGC TCA AGC TTT ACC TCT AAT AGC GTT TTA AAC TTT TTT 108
Met Lys Arg Ser Ser Phe Thr Ser Asn Ser Val Leu Asn Phe Phe
1 5 10 15GTA GTT TTG TCT TTC ATT ACG ATA GGA TTA GTG TTT TTC TTT TTG CGT 156Val Val Leu Ser Phe Ile Thr Ile Gly Leu Val Phe Phe Phe Leu Arg
20 25 30TCC CAA CCC ACT AGC GTA GTT TCT AAA GAA AAT ATC CCT AAA ATT GAA 204Ser Gln Pro Thr Ser Val Val Ser Lys Glu Asn Ile Pro Lys Ile Glu
35 40 45TTA GAA AAT TTT AAA GCG TTT CAA ATC AAC GAT AAA ATC CTT GAT CTG 252Leu Glu Asn Phe Lys Ala Phe Gln Ile Asn Asp Lys Ile Leu Asp Leu
50 55 60TCC ATA GAG GGC AAA AAA GCC CTA CAA TAC GAT GAT CAT GAA ATC TTT 300Ser Ile Glu Gly Lys Lys Ala Leu Gln Tyr Asp Asp His Glu Ile Phe
65 70 75TTT GAT TCC AAA ATC AAG CGC TAT GAT GAA GAC ACC ATT GAA AGC GTT 348Phe Asp Ser Lys Ile Lys Arg Tyr Asp Glu Asp Thr Ile Glu Ser Val80 85 90 95GAG TCT CCT AAG GCC AAA CGG CAG CAG GAT TTG TAT TTC TTC CCT AAT 396Glu Ser Pro Lys Ala Lys Arg Gln Gln Asp Leu Tyr Phe Phe Pro Asn
100 105 110GGG GTT ACT TAT AAA AGA AGC GAT GAT TCC AGT TTT TGG AGT GAA ACA 444Gly Val Thr Tyr Lys Arg Ser Asp Asp Ser Ser Phe Trp Ser Glu Thr
115 120 125GGG ATT TAT AAC CAT AAG GAG CAA AAT TTT AAA GGC AAG GGC CGT TTC 492Gly I1e Tyr Asn His Lys Glu Gln Asn Phe Lys Gly Lys Gly Arg Phe
130 135 140ATT CTC ACT TCA AAG GAC AGC AAG ATT GAA GGG CTT GAC ATT TCT TAT 540Ile Leu Thr Ser Lys Asp Ser Lys Ile Glu Gly Leu Asp Ile Ser Tyr
145 150 155TCG CAT GCA TTA GCT ATT ATT GAA GCT CAA AGC ATT CAA GCG CAT TTA 588Ser His Ala Leu Ala Ile Ile Glu Ala Gln Ser Ile Gln Ala His Leu160 165 170 175TTC TTA GAT GAA ATC AAA CAA AGC CAA AAA GAA AAG AAA AAA TTC CCC 636Phe Leu Asp Glu Ile Lys Gln Ser Gln Lys Glu Lys Lys Lys Phe Pro
180 185 190ACT TTC AAA GGA GGT TTT TAATGCGTTG GTGGTGTTTT TTGGTGTGTT GTTTTGGT 692Thr Phe Lys Gly Gly Phe
195ATTTTAAGCG TGAT 706
(2) Sequence 98 data:
(i) sequence characteristics:
(A) length: 197 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 98: met Lys Arg Ser Ser Phe Thr Ser Asn Ser Val Leu Asn Phe Phe Val 151015 Val Leu Ser Phe Ile Thr Ile Gly Leu Val Phe Phe Phe Leu Arg Ser
20 25 30Gln Pro Thr Ser Val Val Ser Lys Glu Asn Ile Pro Lys Ile Glu Leu
35 40 45Glu Asn Phe Lys Ala Phe Gln Ile Asn Asp Lys Ile Leu Asp Leu Ser
50 55 60Ile Glu Gly Lys Lys Ala Leu Gln Tyr Asp Asp His Glu Ile Phe Phe65 70 75 80Asp Ser Lys Ile Lys Arg Tyr Asp Glu Asp Thr Ile Glu Ser Val Glu
85 90 95Ser Pro Lys Ala Lys Arg Gln Gln Asp Leu Tyr Phe Phe Pro Asn Gly
100 105 110Val Thr Tyr Lys Arg Ser Asp Asp Ser Ser Phe Trp Ser Glu Thr Gly
115 120 125Ile Tyr Asn His Lys Glu Gln Asn Phe Lys Gly Lys Gly Arg Phe Ile
130 135 140Leu Thr Ser Lys Asp Ser Lys Ile Glu Gly Leu Asp Ile Ser Tyr Ser145 150 155 160His Ala Leu Ala Ile Ile Glu Ala Gln Ser Ile Gln Ala His Leu Phe
165 170 175Leu Asp Glu Ile Lys Gln Ser Gln Lys Glu Lys Lys Lys Phe Pro Thr
180 185 190Phe Lys Gly Gly Phe
195
(2) Sequence 99 data:
(i) sequence characteristics:
(A) length: 1010bp
(B) Type (2): nucleic acids
(C) Chaintype: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 130...957
(D) Other information:
(xi) Description of the sequence: sequence 99: AAGCGAGCAA GAATGAATTA AAAATTTTTG GTTGGCACTA CATCATAGAA ACAGGCAGGA 60TTTATAATTA TAATTTTGAA AGCCATTTTT TTGAGCCGAT TGGAGAAACC ATTAAACAAA 120GGAAAAGTC ATG AAA ACT TCT AAA ACA AAA ACC CCT AAA TCC GTT TTA ATC 171
Met Lys Thr Ser Lys Thr Lys Thr Pro Lys Ser Val Leu Ile
1 5 10GCT GGG CCA TGC GTC ATT GAG AGC TTA GAA AAT CTA AGA AGT ATC GCC 219Ala Gly Pro Cys Val Ile Glu Ser Leu Glu Asn Leu Arg Ser Ile Ala15 20 25 30ACT AAA TTG CAA CCC CTA GCC AAC AAC GAG CGG TTG GAT TTT TAT TTT 267Thr Lys Leu Gln Pro Leu Ala Asn Asn Glu Arg Leu Asp Phe Tyr Phe
35 40 45AAA GCG AGT TTT GAT AAG GCG AAC CGC ACG AGT TTA GAG AGT TAC AGA 315Lys Ala Ser Phe Asp Lys Ala Asn Arg Thr Ser Leu Glu Ser Tyr Arg
50 55 60GGG CCT GGT TTA GAA AAA GGC CTA GAA ATG TTA CAA ACG ATC AAA GAG 363Gly Pro Gly Leu Glu Lys Gly Leu Glu Met Leu Gln Thr Ile Lys Glu
65 70 75GAA TTT GGT TAT AAA ATC TTA ACC GAT GTG CAT GAG AGT TAT CAA GCA 411Glu Phe Gly Tyr Lys Ile Leu Thr Asp Val His Glu Ser Tyr Gln Ala
80 85 90AGC GTG GCA GCC AAA GTG GCG GAT ATT TTA CAA ATC CCG GCG TTT TTG 459Ser Val Ala Ala Lys Val Ala Asp Ile Leu Gln Ile Pro Ala Phe Leu95 100 105 110TGC CGC CAA ACG GAT CTG ATT GTA GAA GTG AGC CAG ACT AAC GCT ATT 507Cys Arg Gln Thr Asp Leu Ile Val Glu Val Ser Gln Thr Asn Ala Ile
115 120 125GTC AAT ATC AAA AAA GGG CAA TTC ATG AAC CCA AAA GAC ATG CAA TAT 555Val Asn Ile Lys Lys Gly Gln Phe Met Asn Pro Lys Asp Met Gln Tyr
130 135 140TCT GTT CTA AAG GCC CTT AAA ACG AGA GAT AAA AGC ATT CAA AGC CCC 603Ser Val Leu Lys Ala Leu Lys Thr Arg Asp Lys Ser Ile Gln Ser Pro
145 150 155ACT TAT GAA ACA GCG TTA AAA AAT GGC GTG TGG CTG TGT GAA AGG GGG 651Thr Tyr Glu Thr Ala Leu Lys Asn Gly Val Trp Leu Cys Glu Arg Gly
160 165 170AGC AGC TTT GGG TAT GGG AAT TTA GTG GTG GAT ATG CGC TCT TTA AAA 699Ser Ser Phe Gly Tyr Gly Asn Leu Val Val Asp Met Arg Ser Leu Lys175 180 185 190ATC ATG CGA GAA TTT GCC CCT GTG ATT TTT GAC GCT ACC CAT AGC GTG 747Ile Met Arg Glu Phe Ala Pro Val Ile Phe Asp Ala Thr His Ser Val
195 200 205CAA ATG CCA GGG GGA GCG AAC GGG AAA AGT TCA GGA GAC AGC TCT TTT 795Gln Met Pro Gly Gly Ala Asn Gly Lys Ser Ser Gly Asp Ser Ser Phe
210 215 220GCC CCT ATT TTA GCG AGA GCT GCG GCG GCG GTG GGG ATT GAT GGG TTG 843Ala Pro Ile Leu Ala Arg Ala Ala Ala Ala Val Gly Ile Asp Gly Leu
225 230 235TTT GCT GAA ACG CAT GTT GAT CCT AAA AAC GCC CTA AGC GAT GGA GCA 891Phe Ala Glu Thr His Val Asp Pro Lys Asn Ala Leu Ser Asp Gly Ala
240 245 250AAC ATG CTA AAA CCT GAC GAG CTA GAA CAA TTA GTA ACC GAC ATG TTA 939Asn Met Leu Lys Pro Asp Glu Leu Glu Gln Leu Val Thr Asp Met Leu255 260 265 270AAA ATC CAA AAT TTA TTT TAAAGGAATT TCATGCAAAT CATAGAAGGG AAATTGCA 995Lys Ile Gln Asn Leu Phe
275ATTACAAGGG AATGA 1010
(2) Sequence 100 data:
(i) sequence characteristics:
(A) length: 276 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 100: met Lys Thr Ser Lys Thr Lys Thr Pro Lys Ser Val Leu Ile Ala Gly 151015 Pro Cys Val Ile Glu Ser Leu Glu Asn Leu Arg Ser Ile Ala Thr Lys
20 25 30Leu Gln Pro Leu Ala Asn Asn Glu Arg Leu Asp Phe Tyr Phe Lys Ala
35 40 45Ser Phe Asp Lys Ala Asn Arg Thr Ser Leu Glu Ser Tyr Arg Gly Pro
50 55 60Gly Leu Glu Lys Gly Leu Glu Met Leu Gln Thr Ile Lys Glu Glu Phe65 70 75 80Gly Tyr Lys Ile Leu Thr Asp Val His Glu Ser Tyr Gln Ala Ser Val
85 90 95Ala Ala Lys Val Ala Asp Ile Leu Gln Ile Pro Ala Phe Leu Cys Arg
100 105 110Gln Thr Asp Leu Ile Val Glu Val Ser Gln Thr Asn Ala Ile Val Asn
115 120 125Ile Lys Lys Gly Gln Phe Met Asn Pro Lys Asp Met Gln Tyr Ser Val
130 135 140Leu Lys Ala Leu Lys Thr Arg Asp Lys Ser Ile Gln Ser Pro Thr Tyr145 150 155 160Glu Thr Ala Leu Lys Asn Gly Val Trp Leu Cys Glu Arg Gly Ser Ser
165 170 175Phe Gly Tyr Gly Asn Leu Val Val Asp Met Arg Ser Leu Lys Ile Met
180 185 190Arg Glu Phe Ala Pro Val Ile Phe Asp Ala Thr His Ser Val Gln Met
195 200 205Pro Gly Gly Ala Asn Gly Lys Ser Ser Gly Asp Ser Ser Phe Ala Pro
210 215 220Ile Leu Ala Arg Ala Ala Ala Ala Val Gly Ile Asp Gly Leu Phe Ala225 230 235 240Glu Thr His Val Asp Pro Lys Asn Ala Leu Ser Asp Gly Ala Asn Met
245 250 255Leu Lys Pro Asp Glu Leu Glu Gln Leu Val Thr Asp Met Leu Lys Ile
260 265 270Gln Asn Leu Phe
275
(2) Sequence 101 data:
(i) sequence characteristics:
(A) length: 240bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 59...196
(D) Other information:
(xi) Description of the sequence: sequence 101: AACAATTCTT TTTTAAGCAA AAACAAAACA AAATTAAGGC ATAATCACTC TTTTTAAA 58ATG AAA GGT CGC GTA GCT CAG TTG GTA GAG CAC TAC CTT GAC ATG GTA 106Met Lys Gly Arg Val Ala Gln Leu Val Glu His Tyr Leu Asp Met Val 151015 GTG GCC GCT GGT TCA AGT CCA GTC GTG GCC ACC ATT ATC ACT CCA ATT 154Val Ala Ala Gly Ser Ser Pro Val Val Ala Thr Ile Ile Thr Pro Ile
20 25 30TTA ATT CTC ATT TTT TTG CGA GTT TTT GAT CTT TAT AAA TTC TAAAGGGGTA 206Leu Ile Leu Ile Phe Leu Arg Val Phe Asp Leu Tyr Lys Phe
35 40 45TTAAACGCAC TTCTAATAAC GATTTTATAG CGCT 240
(2) Sequence 102 data:
(i) sequence characteristics:
(A) length: 46 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 102: met Lys Gly Arg Val Ala Gln Leu Val Glu His Tyr Leu Asp Met Val 151015 Val Ala Ala Gly Ser Ser Pro Val Val Ala Thr Ile Ile Thr Pro Ile
20 25 30Leu Ile Leu Ile Phe Leu Arg Val Phe Asp Leu Tyr Lys Phe
35 40 45
(2) Sequence 103 data:
(i) sequence characteristics:
(A) length: 1382bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 91...1329
(D) Other information:
(xi) Description of the sequence: sequence 103: ACCACCCCTT AATCTCAAAA AACCCCAATC ATAAAAAGCT TTATGCTACA ATGAAAGCTC 60TTTAACACGA TAAAAGGGCG GTTTAATAGC ATG GCA CAA GAA AAA GCA GTT CCA 114
Met Ala Gln Glu Lys Ala Val Pro
1 5AGA GAT CCT AAA AAA CTC AAT GCG TTT GAT TTG CGT TGG ATG GTG TCC 162Arg Asp Pro Lys Lys Leu Asn Ala Phe Asp Leu Arg Trp Met Val Ser
10 15 20TTA TTT GGC ACG GCG GTG GGG GCT GGG ATT TTA TTT TTG CCT ATT AGA 210Leu Phe Gly Thr Ala Val Gly Ala Gly Ile Leu Phe Leu Pro Ile Arg25 30 35 40GCC GGT GGG CAT GGG GTA TGG GCT ATT GTG GTA ATG AGC GCG ATC ATT 258Ala Gly Gly His Gly Val Trp Ala Ile Val Val Met Ser Ala Ile Ile
45 50 55TTC CCT TTA ACT TAT CTA GGG CAT AGA GCT TTA GCT TAT TTC ATA GGA 306Phe Pro Leu Thr Tyr Leu Gly His Arg Ala Leu Ala Tyr Phe Ile Gly
60 65 70TCT AAA GAC AAA GAA GAC ATT ACC ATG GTC GTT CGC TCT CAT TTT GGC 354Ser Lys Asp Lys Glu Asp Ile Thr Met Val Val Arg Ser His Phe Gly
75 80 85GCT CAATGG GGT TTT CTT ATC ACT TTG CTT TAT TTC TTA GCG ATT TAT 402Ala Gln Trp Gly Phe Leu Ile Thr Leu Leu Tyr Phe Leu Ala Ile Tyr
90 95 100CCT ATT TGC TTG GTT TAT GGG GTG GGT ATC ACT AAC GTG TTT GAT CAT 450Pro Ile Cys Leu Val Tyr Gly Val Gly Ile Thr Asn Val Phe Asp His105 110 115 120TTT TTC ACT AAC CAG TTG CAT TTA GCG CCT TTT CAT CGG GGA TTA TTG 498Phe Phe Thr Asn Gln Leu His Leu Ala Pro Phe His Arg Gly Leu Leu
125 130 135GCT GTA GCG TTA GTT TCT TTA ATG ATG TTG GTG ATG GTT TTT AAC GCT 546Ala Val Ala Leu Val Ser Leu Met Met Leu Val Met Val Phe Asn Ala
140 145 150ACG ATT GTT ACG CGC ATT TGT AAC GCT TTA GTG TAT CCT TTA TGC TTG 594Thr Ile Val Thr Arg Ile Cys Asn Ala Leu Val Tyr Pro Leu Cys Leu
155 160 165ATT TTA TTG CTT TTT TCT TTG TAT CTT ATC CCT TAT TGG CAA GGC GCT 642Ile Leu Leu Leu Phe Ser Leu Tyr Leu Ile Pro Tyr Trp Gln Gly Ala
170 175 180AAT CTT TTT GTG GTG CCG AGT TTT AAA GAA TTT GTG TTA GCG ATT TGG 690Asn Leu Phe Val Val Pro Ser Phe Lys Glu Phe Val Leu Ala Ile Trp185 190 195 200CTA ACC TTA CCG GTG CTT GTG TTT GCA TTC GAC CAT AGC CCC ATC ATT 738Leu Thr Leu Pro Val Leu Val Phe Ala Phe Asp His Ser Pro Ile Ile
205 210 215TCA ACC TTC ACT CAA AAT GTG GGA AAA GAA TAC GGC GTT TTC AAA GAA 786Ser Thr Phe Thr Gln Asn Val Gly Lys Glu Tyr Gly Val Phe Lys Glu
220 225 230TAC AAA CTC AAT CAA ATT GAA TTA GGG ACA TCG CTG ATG CTT TTA GGG 834Tyr Lys Leu Asn Gln Ile Glu LeuGly Thr Ser Leu Met Leu Leu Gly
235 240 245TIT GTG ATG TTT TTT GTG TTT TCG TGC GTC ATG TGC TTG AAT GCT GAT 882Phe Val Met Phe Phe Val Phe Ser Cys Val Met Cys Leu Asn Ala Asp
250 255 260GAT TTT GTG AAA GCA AGG GAA CAA AAT ATC CCC ATT TTA AGC TAT TTG 930Asp Phe Val Lys Ala Arg Glu Gln Asn Ile Pro Ile Leu Ser Tyr Leu265 270 275 280GCT AAC ACT TTA AAC AAC CCT TTA ATC AAT TAT GCG GGG CCT GTG GTG 978Ala Asn Thr Leu Asn Asn Pro Leu Ile Asn Tyr Ala Gly Pro Val Val
285 290 295GCT TTT TTA GCG ATT TTT TCA TCT TTT TTT GGG CAT TAT TAT GGG GCT 1026Ala Phe Leu Ala Ile Phe Ser Ser Phe Phe Gly His Tyr Tyr Gly Ala
300 305 310AAG GAG GGT TTA GAA GGC ATT ATT ATT CAA AGC TTA AAA TTG AAA AAA 1074Lys Glu Gly Leu Glu Gly Ile Ile Ile Gln Ser Leu Lys Leu Lys Lys
315 320 325GCT TCT AAA CCC TTG AGC GTT AGC GTA ACG ATT TTT TTA TGG CTG ACT 1122Ala Ser Lys Pro Leu Ser Val Ser Val Thr Ile Phe Leu Trp Leu Thr
330 335 340ATC ACG CTT GTG GCT TAT ATT AAC CCC AAT ATC TTG GAT TTT ATT GAA 1170Ile Thr Leu Val Ala Tyr Ile Asn Pro Asn Ile Leu Asp Phe Ile Glu345 350 355 360AAT TTA GGC GGC CCC ATT ATC GCG CTC ATT CTG TTT GTG ATG CCC ATG 1218Asn Leu Gly Gly Pro Ile Ile Ala Leu Ile Leu Phe Val Met Pro Met
365 370 375ATA GCT TTT TAT AGT GTT TCT AGT TTG AAG CGT TTT AGA AAT TTC AAA 1266Ile Ala Phe Tyr Ser Val Ser Ser Leu Lys Arg Phe Arg Asn Phe Lys
380 385 390GTG GAT ATT TTT GTG TTT GTC TTT GGG AGC TTG ACG GCT TTG AGC GTG 1314Val Asp Ile Phe Val Phe Val Phe Gly Ser Leu Thr Ala Leu Ser Val
395 400 405TTT TTA GGA CTA TTT TAATGGCTAG TTTTTCTATT TTATCTATTT TTAAAATCGG C 1370Phe Leu Gly Leu Phe
410GTGGGGCCTA GC 1382
(2) Sequence 104 data:
(i) sequence characteristics:
(A) length: 413 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 104: met Ala Gln Glu Lys Ala Val Pro Arg Asp Pro Lys Lys Leu Asn Ala 151015 Phe Asp Leu Arg Trp Met Val Ser Leu Phe Gly Thr Ala Val Gly Ala
20 25 30Gly Ile Leu Phe Leu Pro Ile Arg Ala Gly Gly His Gly Val Trp Ala
35 40 45Ile Val Val Met Ser Ala Ile Ile Phe Pro Leu Thr Tyr Leu Gly His
50 55 60Arg Ala Leu Ala Tyr Phe Ile Gly Ser Lys Asp Lys Glu Asp Ile Thr65 70 75 80Met Val Val Arg Ser His Phe Gly Ala Gln Trp Gly Phe Leu Ile Thr
85 90 95Leu Leu Tyr Phe Leu Ala Ile Tyr Pro Ile Cys Leu Val Tyr Gly Val
100 105 110Gly Ile Thr Asn Val Phe Asp His Phe Phe Thr Asn Gln Leu His Leu
115 120 125Ala Pro Phe His Arg Gly Leu Leu Ala Val Ala Leu Val Ser Leu Met
130 135 140Met Leu Val Met Val Phe Asn Ala Thr Ile Val Thr Arg Ile Cys Asn145 150 155 160Ala Leu Val Tyr Pro Leu Cys Leu Ile Leu Leu Leu Phe Ser Leu Tyr
165 170 175Leu Ile Pro Tyr Trp Gln Gly Ala Asn Leu Phe Val Val Pro Ser Phe
180 185 190Lys Glu Phe Val Leu Ala Ile Trp Leu Thr Leu Pro Val Leu Val Phe
195 200 205Ala Phe Asp His Ser Pro Ile Ile Ser Thr Phe Thr Gln Asn Val Gly
210 215 220Lys Glu Tyr Gly Val Phe Lys Glu Tyr Lys Leu Asn Gln Ile Glu Leu225 230 235 240Gly Thr Ser Leu Met Leu Leu Gly Phe Val Met Phs Phe Val Phe Ser
245 250 255Cys Val Met Cys Leu Asn Ala Asp Asp Phe Val Lys Ala Arg Glu Gln
260 265 270Asn Ile Pro Ile Leu Ser Tyr Leu Ala Asn Thr Leu Asn Asn Pro Leu
275 280 285Ile Asn Tyr Ala Gly Pro Val Val Ala Phe Leu Ala Ile Phe Ser Ser
290 295 300Phe Phe Gly His Tyr Tyr Gly Ala Lys Glu Gly Leu Glu Gly Ile Ile305 310 315 320Ile Gln Ser Leu Lys Leu Lys Lys Ala Ser Lys Pro Leu Ser Val Ser
325 330 335Val Thr Ile Phe Leu Trp Leu Thr Ile Thr Leu Val Ala Tyr Ile Asn
340 345 350Pro Asn Ile Leu Asp Phe Ile Glu Asn Leu Gly Gly Pro Ile Ile Ala
355 360 365Leu Ile Leu Phe Val Met Pro Met Ile Ala Phe Tyr Ser Val Ser Ser
370 375 380Leu Lys Arg Phe Arg Asn Phe Lys Val Asp Ile Phe Val Phe Val Phe385 390 395 400Gly Ser Leu Thr Ala Leu Ser Val Phe Leu Gly Leu Phe
405 410
(2) Sequence 105 data:
(i) sequence characteristics:
(A) length: 875bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 63...827
(D) Other information:
(xi) Description of the sequence: sequence 105: TTTGCCACCT TATTGCAAAC CCTAATGCTA ACGCACTACT TTTTTATCTT TAAAGAGAAA 60GA ATG CTA GAT TTT ATT CAA GAG CTT AGC ACC CCC CAT GTT AGG GAT 107Met Leu Asp Phe Ile Gln Glu Leu Ser Thr Pro His Val Arg Asp
1 5 10 15TTT TTC TTG TTG TTT TTA AGG GTT AGC GGC GTG CTG TCT TTC TTC CCT 155Phe Phe Leu Leu Phe Leu Arg Val Ser Gly Val Leu Ser Phe Phe Pro
20 25 30TTT TTT GAA AAC CAT TTA GTG CCT TTG TCG GTG CGT GGG GCT TTG AGT 203Phe Phe Glu Asn His Leu Val Pro Leu Ser Val Arg Gly Ala Leu Ser
35 40 45 TTG TAT GTG AGC GCG ATT TTT TAC CCC ACT TTA GAA TTT TCA AAC GCC 251Leu Tyr Val Ser Ala Ile Phe Tyr Pro Thr Leu Glu Phe Ser Asn Ala
50 55 60GCT TAC ACG CCA GAG GGT TTT ATC ATT GCT TGC TTG TGC GAA TTG TTT 299Ala Tyr Thr Pro Glu Gly Phe Ile Ile Ala Cys Leu Cys Glu Leu Phe
65 70 75TTA GGG GTG TGC GCG TCT GTC TTT TTA CAA ATC GTC TTT GCA AGC TTA 347Leu Gly Val Cys Ala Ser Val Phe Leu Gln Ile Val Phe Ala Ser Leu80 85 90 95GTG TTT GCA ACC GAT AGC ATC AGC TTT TCT ATG GGG CTT ACG ATG GCG 395Val Phe Ala Thr Asp Ser Ile Ser Phe Ser Met Gly Leu Thr Met Ala
100 105 110AGC GCG TAT GAT CCT ATT TCA GGA TCG CAA AAA CCC ATT GTG GGG CAA 443Ser Ala Tyr Asp Pro Ile Ser Gly Ser Gln Lys Pro Ile Val Gly Gln
115 120 125GCC CTT TTA TTG TTA GCG ATT TTA ATT TTA TTG GAT TTA TCG TTC CAC 491Ala Leu Leu Leu Leu Ala Ile Leu Ile Leu Leu Asp Leu Ser Phe His
130 135 140CAT CAA ATC ATT TTG TTT GTG GAT CAC AGC TTA AAA GCC GTC CCT TTA 539His Gln Ile Ile Leu Phe Val Asp His Ser Leu Lys Ala Val Pro Leu
145 150 155GGG CAA TTT GTC TTT GAG CCA GCG TTG GCT AAA AAC ATC GTT AAA GCC 587Gly Gln Phe Val Phe Glu Pro Ala Leu Ala Lys Asn Ile Val Lys Ala160 165 170 175TTT TCG CAC CTC TTT GTC ATA GGG TTT TCT ATG GCG TTC CCT ATT TTA 635Phe Ser His Leu Phe Val Ile Gly Phe Ser Met Ala Phe Pro Ile Leu
180 185 190TGC TTG GTG TTA TTG AGC GAT ATTATT TTT GGC ATG ATC ATG AAA ACC 683Cys Leu Val Leu Leu Ser Asp Ile Ile Phe Gly Met Ile Met Lys Thr
195 200 205CAC CCT CAG TTC AAC CTG CTC GCT ATT GGG TTT CCG GTT AAA ATT GCG 731His Pro Gln Phe Asn Leu Leu Ala Ile Gly Phe Pro Val Lys Ile Ala
210 215 220ATC GGG TTT GTG GGC ATT ATC TTA ATC GCT TCG GCT ATC ATG GGG CGT 779Ile Gly Phe Val Gly Ile Ile Leu Ile Ala Ser Ala Ile Met Gly Arg
225 230 235TTT AAA GAA GAA ATC AGC CTG GCC TTT AGC GCC ATT AGC AAA ATC TTT T 828Phe Lys Glu Glu Ile Ser Leu Ala Phe Ser Ala Ile Ser Lys Ile Phe240 245 250 255AAAGGATAAA CATGATTAGT TTTAAAGAAG CTCTAAAAAT CCATTCT 875
(2) Sequence 106 data:
(i) sequence characteristics:
(A) length: 255 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 106: met Leu Asp Phe Ile Gln Glu Leu Ser Thr Pro His Val Arg Asp Phe 151015 Phe Leu Leu Phe Leu Arg Val Ser Gly Val Leu Ser Phe Phe Pro Phe
20 25 30Phe Glu Asn His Leu Val Pro Leu Ser Val Arg Gly Ala Leu Ser Leu
35 40 45Tyr Val Ser Ala Ile Phe Tyr Pro Thr Leu Glu Phe Ser Asn Ala Ala
50 55 60Tyr Thr Pro Glu Gly Phe Ile Ile Ala CysLeu Cys Glu Leu Phe Leu65 70 75 80Gly Val Cys Ala Ser Val Phe Leu Gln Ile Val Phe Ala Ser Leu Val
85 90 95Phe Ala Thr Asp Ser Ile Ser Phe Ser Met Gly Leu Thr Met Ala Ser
100 105 110Ala Tyr Asp Pro Ile Ser Gly Ser Gln Lys Pro Ile Val Gly Gln Ala
115 120 125Leu Leu Leu Leu Ala Ile Leu Ile Leu Leu Asp Leu Ser Phe His His
130 135 140Gln Ile Ile Leu Phe Val Asp His Ser Leu Lys Ala Val Pro Leu Gly145 150 155 160Gln Phe Val Phe Glu Pro Ala Leu Ala Lys Asn Ile Val Lys Ala Phe
165 170 175Ser His Leu Phe Val Ile Gly Phe Ser Met Ala Phe Pro Ile Leu Cys
180 185 190Leu Val Leu Leu Ser Asp Ile Ile Phe Gly Met Ile Met Lys Thr His
195 200 205Pro Gln Phe Asn Leu Leu Ala Ile Gly Phe Pro Val Lys Ile Ala Ile
210 215 220Gly Phe Val Gly Ile Ile Leu Ile Ala Ser Ala Ile Met Gly Arg Phe225 230 235 240Lys Glu Glu Ile Ser Leu Ala Phe Ser Ala Ile Ser Lys Ile Phe
245 250 255
(2) Sequence 107 data:
(i) sequence characteristics:
(A) length: 1160bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 373...1110
(D) Other information:
(xi) Description of the sequence: sequence 107: GAGATATTAA AAAGAGATAT TAAAATGGCT TTTAAGCTTC TATGAAGCCC CCCCCCCTCC 60TCCTTTTGCC CTTTATTTCG TGGGCAAATC GCCCACAGGA CAAGCGGCCA CACCCACGCT 120TGGGCGGGTG ATTTTTTCTA CATTTTCTTG AGCTTTTTTG GGGTCATTCA CCCAAGTTTT 180ATAGAACTCA AAAGGGCATT CCGCCACACC CTTATCCCCA TCGCCACTAG CAAAAACCCC 240ACTATAACCT CTGTGCAAGA GTTTGAAGAG TTGGTTTTGG CTTTGGTCGT ATTTTCTCGC 300ATCACGGATT TGTTGCACAG AAAGTTGAGC GTATTGAAGA CCATTTTCTT CTTCCCCGCA 360TTCGCCCAAA GT ATG CCC GTC AAA ACC AAT AAT GCT AGA ATG CCC AAA ATA 411
Met Pro Val Lys Thr Asn Asn Ala Arg Met Pro Lys Ile
1 5 10GGA ATA CAC CCC ATC AAA ACC GGT CGC ATT CGC TAC CGC TAC ATA ACA 459Gly Ile His Pro Ile Lys Thr Gly Arg Ile Arg Tyr Arg Tyr Ile Thr
15 20 25TTG ATT GGC CCA CGC CAT AGC TTT TAC TAT TGC AAT TTG TTG CTC CTT 507Leu Ile Gly Pro Arg His Ser Phe Tyr Tyr Cys Asn Leu Leu Leu Leu30 35 40 45AGC CGG ATA CAT GTA ACC TTG ACA GCG CAC AAT GAG TTC TGC CCC ACG 555Ser Arg Ile His Val Thr Leu Thr Ala His Asn Glu Phe Cys Pro Thr
50 55 60CAT CGC GCA ATC GCG CCA AAT TTC AGG GTA GTT TCC ATC ATC GCA AAT 603His Arg Ala Ile Ala Pro Asn Phe Arg Val Val Ser Ile Ile Ala Asn
65 70 75AAT CAA AGA AAC TTT CAA GCC CTT AGG CCC ATC AAC CAC ATA AGT TTT 651Asn Gln Arg Asn Phe Gln Ala LeuArg Pro Ile Asn His Ile Ser Phe
80 85 90ATC CCC AGG ATA CCA ACA TTC AAT AGG GCA CCA AGG CAA GAT TTT GCG 699Ile Pro Arg Ile Pro Thr Phe Asn Arg Ala Pro Arg Gln Asp Phe Ala
95 100 105GTA TTT TTG CAC GAT CTC ACC CTT ATC ATT GAC AAG AAT CAA AGT GTT 747Val Phe Leu His Asp Leu Thr Leu Ile Ile Asp Lys Asn Gln Ser Val110 115 120 125ATA GGG ATT CTT TTT GGC TTG CTC GTG TTT TTC CCC TGT CAA AGA GAA 795Ile Gly Ile Leu Phe Gly Leu Leu Val Phe Phe Pro Cys Gln Arg Glu
130 135 140CAC TCC CCA AAC CTT GTT TTT CTT ACA AGC TTC AGC AAA GAT CGC GGT 843His Ser Pro Asn Leu Val Phe Leu Thr Ser Phe Ser Lys Asp Arg Gly
145 150 155TTC TTC TCC AGG AAC GCT TGC GGC TGT ATC AAA CAT TTC TTG TCT GTC 891Phe Phe Ser Arg Asn Ala Cys Gly Cys Ile Lys His Phe Leu Ser Val
160 165 170ATA CAT AAT CCC ATG CGT GCT GTA TTC AGG GAA AAT AAT CAG ATC CAA 939Ile His Asn Pro Met Arg Ala Val Phe Arg Glu Asn Asn Gln Ile Gln
175 180 185CCC AGG CAA ACC CTG TTT GAC CCC ACC AAT CAC CTT AGC GAT ATT GCG 987Pro Arg Gln Thr Leu Phe Asp Pro Thr Asn His Leu Ser Asp Ile Ala190 195 200 205ACA ATT TTC CAA CAC CTC ATT CTT AGT GTG GAG TCT AGG CAT CTT ATA 1035Thr Ile Phe Gln His Leu Ile Leu Ser Val Glu Ser Arg His Leu Ile
210 215 220ATT AAC TAC CGC TAC ACC CAC AGT ATC TGG GCT GCT ACT AAT ATC TCC 1083Ile Asn Tyr Arg Tyr Thr His Ser Ile Trp Ala Ala Thr Asn Ile Ser
225 230235ATG TCT CAT ATT ATG TTC CTT GTT TTT TGATGAGAGT TCCTACAAAC CCTCTAC 1137Met Ser His Ile Met Phe Leu Val Phe
240 245TTGAATTTAT AAAATAATTG TGT 1160
(2) Sequence 108 data:
(i) sequence characteristics:
(A) length: 246 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 108: met Pro Val Lys Thr Asn Asn Ala Arg Met Pro Lys Ile Gly Ile His 151015 Pro Ile Lys Thr Gly Arg Ile Arg Tyr Arg Tyr Ile Thr Leu Ile Gly
20 25 30Pro Arg His Ser Phe Tyr Tyr Cys Asn Leu Leu Leu Leu Ser Arg Ile
35 40 45His Val Thr Leu Thr Ala His Asn Glu Phe Cys Pro Thr His Arg Ala
50 55 60Ile Ala Pro Asn Phe Arg Val Val Ser Ile Ile Ala Asn Asn Gln Arg65 70 75 80Asn Phe Gln Ala Leu Arg Pro Ile Asn His Ile Ser Phe Ile Pro Arg
85 90 95Ile Pro Thr Phe Asn Arg Ala Pro Arg Gln Asp Phe Ala Val Phe Leu
100 105 110His Asp Leu Thr Leu Ile Ile Asp Lys Asn Gln Ser Val Ile Gly Ile
115 120 125Leu Phe Gly Leu Leu Val Phe Phe Pro Cys Gln Arg Glu His Ser Pro
130 135 140Asn Leu Val Phe Leu Thr Ser Phe Ser Lys Asp Arg Gly Phe Phe Ser145 150 155 160Arg Asn Ala Cys Gly Cys Ile Lys His Phe Leu Ser Val Ile His Asn
165 170 175Pro Met Arg Ala Val Phe Arg Glu Asn Asn Gln Ile Gln Pro Arg Gln
180 185 190Thr Leu Phe Asp Pro Thr Asn His Leu Ser Asp Ile Ala Thr Ile Phe
195 200 205Gln His Leu Ile Leu Ser Val Glu Ser Arg His Leu Ile Ile Asn Tyr
210 215 220Arg Tyr Thr His Ser Ile Trp Ala Ala Thr Asn Ile Ser Met Ser His225 230 235 240Ile Met Phe Leu Val Phe
245
(2) Data of sequence 109:
(i) sequence characteristics:
(A) length: 1661bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 79...1611
(D) Other information:
(xi) Description of the sequence: sequence 109: GGCTTTATAA AAAATGTTAG AAACCCTTAC AAAACAAGCT AATATATTCT ATTCAATTTG 60CCTCAAGGAC AAACAAAC ATG AAA AAA CTT CTT TAT ACC ATA CTC GCG CTT 111
Met Lys Lys Leu Leu Tyr Thr Ile Leu Ala Leu
1 5 10CTT TTA ATC GGC CTT TTA ACA ATC TAT CTC ATC CTT TTT ACA GAA TGG 159Leu Leu Ile Gly Leu Leu Thr Ile Tyr Leu Ile Leu Phe Thr Glu Trp
15 20 25GGG AAT AAG ATC ATC GCT TCG TAT ATA GAG AAA AAA ATC AAC CCG AAC 207Gly Asn Lys Ile Ile Ala Ser Tyr Ile Glu Lys Lys Ile Asn Pro Asn
30 35 40GAG CAC TAC TTG AGC GTT AAA ACC TTT AAA TTG AGA TTC AAC TCT TTG 255Glu His Tyr Leu Ser Val Lys Thr Phe Lys Leu Arg Phe Asn Ser Leu
45 50 55GAT TTT AAA GCT CAA GCC AAC GAT GAT TCC ACG CTC ATT CTT AAG GGG 303Asp Phe Lys Ala Gln Ala Asn Asp Asp Ser Thr Leu Ile Leu Lys Gly60 65 70 75GAT TTT TCA CTT TTA AAG CAA AGC GTA AAT TTG AAT TAC CAT ATA GAT 351Asp Phe Ser Leu Leu Lys Gln Ser Val Asn Leu Asn Tyr His Ile Asp
80 85 90ATT AAA GAT TTA CGC TCT TTC AAA GAA TGG ATA CCC TAC CCT TTA AGG 399Ile Lys Asp Leu Arg Ser Phe Lys Glu Trp Ile Pro Tyr Pro Leu Arg
95 100 105GGG GCT GTT ATC ACT TCT GGG AAT ATT AAA GGG CAT AGA AAA GCC CTT 447Gly Ala Val Ile Thr Ser Gly Asn Ile Lys Gly His Arg Lys Ala Leu
110 115 120ATG ATT CAA GGC GTC TCT AAT GTG GCT CAA TCC CAC ACT GCC TAC AAT 495Met Ile Gln Gly Val Ser Asn Val Ala Gln Ser His Thr Ala Tyr Asn
125 130 135GCC CTT TTA GAT GAT TTC AAG CTT TCT CGC TTA AAT TTG AAC GCA CAA 543Ala Leu Leu Asp Asp Phe Lys Leu Ser Arg Leu Asn Leu Asn Ala Gln140 145 150 155GAC GCC AAT TTA GAA GAT TTG CTT TAT TTA ATC AAT CGCCCC GCT TAT 591Asp Ala Asn Leu Glu Asp Leu Leu Tyr Leu Ile Asn Arg Pro Ala Tyr
160 165 170GCG AAC GCA AAA GTG TCC TTA CAG GCG GAT TTT AAC TCT CTA AAG CCT 639Ala Asn Ala Lys Val Ser Leu Gln Ala Asp Phe Asn Ser Leu Lys Pro
175 180 185TTA GAG GGG CAT TTG ATC CTA ACA GCT AAT AAC GCT TTA ATC AAT AAC 687Leu Glu Gly His Leu Ile Leu Thr Ala Asn Asn Ala Leu Ile Asn Asn
190 195 200GCC CTA ATC AAT CAA ATT TTT CAT TTA AAC CTT AAA GAC ACG CTT GTT 735Ala Leu Ile Asn Gln Ile Phe His Leu Asn Leu Lys Asp Thr Leu Val
205 210 215TTC AGC CTC TCG CAT TCA AGC GAC TTT AAA GGA AAC AAA GCC ATC AGC 783Phe Ser Leu Ser His Ser Ser Asp Phe Lys Gly Asn Lys Ala Ile Ser220 225 230 235GAT ACC ACC CTG ACT AGC CCT TTA GCC AAT TTC AAA GCC CTA AAA AGC 831Asp Thr Thr Leu Thr Ser Pro Leu Ala Asn Phe Lys Ala Leu Lys Ser
240 245 250GAA TAC CTT TTC TCT ATT TTA AAA CTC AAC GCC CCC TAC ACT TTA GAA 879Glu Tyr Leu Phe Ser Ile Leu Lys Leu Asn Ala Pro Tyr Thr Leu Glu
255 260 265ATC CCC AAT CTA GCC AAA CTC TAT AAC ATT ACC AAC CAC CCC TTA AAA 927Ile Pro Asn Leu Ala Lys Leu Tyr Asn Ile Thr Asn His Pro Leu Lys
270 275 280GGG AGC TTG ACT TTA AAA GGC GCT ATA GAA CAA AGC CCC AAA CTT TTA 975Gly Ser Leu Thr Leu Lys Gly Ala Ile Glu Gln Ser Pro Lys Leu Leu
285 290 295AAA GTC AGC GGC CAT TCA AAT TTA CTA GAC GGC GCG CTG GAT TTC ACG 1023Lys Val Ser Gly His Ser Asn Leu Leu Asp Gly Ala Leu Asp Phe Thr300 305 310 315CTT TTA AAT AAA GAT TTG AAA GGG CGT TTT TCC AAT ATT TCC ACT TTA 1071Leu Leu Asn Lys Asp Leu Lys Gly Arg Phe Ser Asn Ile Ser Thr Leu
320 325 330AAA GCT TTA GAT TTA TTC CAT TAC CCT AAG TTT TTC CAA TCC GTT GCA 1119Lys Ala Leu Asp Leu Phe His Tyr Pro Lys Phe Phe Gln Ser Val Ala
335 340 345GAC GCT AAT TTG GAT TAT GAT CTT ATC GCT AAG CAA GGC GTA TTG AAA 1167Asp Ala Asn Leu Asp Tyr Asp Leu Ile Ala Lys Gln Gly Val Leu Lys
350 355 360GCC CGC CTA AAA AAC GCA AGA TTC CTC AAA AAT GCA TTC AGC GAT TTT 1215Ala Arg Leu Lys Asn Ala Arg Phe Leu Lys Asn Ala Phe Ser Asp Phe
365 370 375CTC TAC TCC ATT TCT AAA TTT GAT ATT ACA AAA GAA ATT TAT AAC GAT 1263Leu Tyr Ser Ile Ser Lys Phe Asp Ile Thr Lys Glu Ile Tyr Asn Asp380 385 390 395GCC AAT CTG GTA AGC CAA ATC AAC CAG CAA CGC CTG CTC TCT GAT CTG 1311Ala Asn Leu Val Ser Gln Ile Asn Gln Gln Arg Leu Leu Ser Asp Leu
400 405 410AGT TTA AAA AGC CCC AAA ACC CAA TTG AAA ATC CAT AAC GGT TTG TTG 1359Ser Leu Lys Ser Pro Lys Thr Gln Leu Lys Ile His Asn Gly Leu Leu
415 420 425GAT TTA AAC ACC AAA CAA ATG AAC ATG CTC ATG GAT GCG GAA ATT TTA 1407Asp Leu Asn Thr Lys Gln Met Asn Met Leu Met Asp Ala Glu Ile Leu
430 435 440AAA TTC ATT TTT AAA ATG AAA CTT CAA GGC AAC ATG CAC CAG CCA AAA 1455Lys Phe Ile Phe Lys Met Lys Leu Gln Gly Asn Met His Gln Pro Lys
445 450 455TTT TCT CTC ATT TTA AAC GAAAAA GCC ATT CAG CAA AAC TTG CAA CAA 1503Phe Ser Leu Ile Leu Asn Glu Lys Ala Ile Gln Gln Asn Leu Gln Gln460 465 470 475GGC TTG AAA GAA ATC TTA AAA AAC GAC ACC CTT AAA AAA GGT TTA GAT 1551Gly Leu Lys Glu Ile Leu Lys Asn Asp Thr Leu Lys Lys Gly Leu Asp
480 485 490CAT TTG CTT AAA GAT GAT AAG CTC AAA GAA AAG CTT GAA AAA GGG CTT 1599His Leu Leu Lys Asp Asp Lys Leu Lys Glu Lys Leu Glu Lys Gly Leu
495 500 505AAG GGG CTT TTT TAAAATTTTA AAGGATAGAA ATGGCGCACA TTTTAGTTAG CGGGG 1656Lys Gly Leu Phe
510CGACT 1661
(2) Sequence 110 data:
(i) sequence characteristics:
(A) length: 511 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 110: met Lys Lys Leu Leu Tyr Thr Ile Leu Ala Leu Leu Leu Ile Gly Leu 151015 Leu Thr Ile Tyr Leu Ile Leu Phe Thr Glu Trp Gly Asn Lys Ile Ile
20 25 30Ala Ser Tyr Ile Glu Lys Lys Ile Asn Pro Asn Glu His Tyr Leu Ser
35 40 45Val Lys Thr Phe Lys Leu Arg Phe Asn Ser Leu Asp Phe Lys Ala Gln
50 55 60Ala Asn Asp Asp Ser Thr Leu Ile Leu Lys Gly Asp Phe Ser Leu Leu65 70 7580Lys Gln Ser Val Asn Leu Asn Tyr His Ile Asp Ile Lys Asp Leu Arg
85 90 95Ser Phe Lys Glu Trp Ile Pro Tyr Pro Leu Arg Gly Ala Val Ile Thr
100 105 110Ser Gly Asn Ile Lys Gly His Arg Lys Ala Leu Met Ile Gln Gly Val
115 120 125Ser Asn Val Ala Gln Ser His Thr Ala Tyr Asn Ala Leu Leu Asp Asp
130 135 140Phe Lys Leu Ser Arg Leu Asn Leu Asn Ala Gln Asp Ala Asn Leu Glu145 150 155 160Asp Leu Leu Tyr Leu Ile Asn Arg Pro Ala Tyr Ala Asn Ala Lys Val
165 170 175Ser Leu Gln Ala Asp Phe Asn Ser Leu Lys Pro Leu Glu Gly His Leu
180 185 190Ile Leu Thr Ala Asn Asn Ala Leu Ile Asn Asn Ala Leu Ile Asn Gln
195 200 205Ile Phe His Leu Asn Leu Lys Asp Thr Leu Val Phe Ser Leu Ser His
210 215 220Ser Ser Asp Phe Lys Gly Asn Lys Ala Ile Ser Asp Thr Thr Leu Thr225 230 235 240Ser Pro Leu Ala Asn Phe Lys Ala Leu Lys Ser Glu Tyr Leu Phe Ser
245 250 255Ile Leu Lys Leu Asn Ala Pro Tyr Thr Leu Glu Ile Pro Asn Leu Ala
260 265 270Lys Leu Tyr Asn Ile Thr Asn His Pro Leu Lys Gly Ser Leu Thr Leu
275 280 285Lys Gly Ala Ile Glu Gln Ser Pro Lys Leu Leu Lys Val Ser Gly His
290 295300Ser Asn Leu Leu Asp Gly Ala Leu Asp Phe Thr Leu Leu Asn Lys Asp305 310 315 320Leu Lys Gly Arg Phe Ser Asn Ile Ser Thr Leu Lys Ala Leu Asp Leu
325 330 335Phe His Tyr Pro Lys Phe Phe Gln Ser Val Ala Asp Ala Asn Leu Asp
340 345 350Tyr Asp Leu Ile Ala Lys Gln Gly Val Leu Lys Ala Arg Leu Lys Asn
355 360 365Ala Arg Phe Leu Lys Asn Ala Phe Ser Asp Phe Leu Tyr Ser Ile Ser
370 375 380Lys Phe Asp Ile Thr Lys Glu Ile Tyr Asn Asp Ala Asn Leu Val Ser385 390 395 400Gln Ile Asn Gln Gln Arg Leu Leu Ser Asp Leu Ser Leu Lys Ser Pro
405 410 415Lys Thr Gln Leu Lys Ile His Asn Gly Leu Leu Asp Leu Asn Thr Lys
420 425 430Gln Met Asn Met Leu Met Asp Ala Glu Ile Leu Lys Phe Ile Phe Lys
435 440 445Met Lys Leu Gln Gly Asn Met His Gln Pro Lys Phe Ser Leu Ile Leu
450 455 460Asn Glu Lys Ala Ile Gln Gln Asn Leu Gln Gln Gly Leu Lys Glu Ile465 470 475 480Leu Lys Asn Asp Thr Leu Lys Lys Gly Leu Asp His Leu Leu Lys Asp
485 490 495Asp Lys Leu Lys Glu Lys Leu Glu Lys Gly Leu Lys Gly Leu Phe
500 505 510
(2) Sequence 111 data:
(i) sequence characteristics:
(A) length: 397bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 53...352
(D) Other information:
(xi) Description of the sequence: sequence 111: CTAATTCTGT CTATTACACC AACAATCAAT CTCAAAACAA AGGACATGAAAG ATG AAA 58
Met Lys
1ACA AAA CAT AAA GGA ATA AGA ATG TTT AAG CAA ATT CGT AGA ATG ATG 106Thr Lys His Lys Gly Ile Arg Met Phe Lys Gln Ile Arg Arg Met Met
5 10 15AGT TTG GCA ATA TTA ATG CCT AGT TTT TTA TTG GCG GCA CCA GAT TAC 154Ser Leu Ala Ile Leu Met Pro Ser Phe Leu Leu Ala Ala Pro Asp Tyr
20 25 30AAA CAA AAA TTC ACT CAA ATA TTG GAT TTC ATA AGC AAT GAC TTT ATC 202Lys Gln Lys Phe Thr Gln Ile Leu Asp Phe Ile Ser Asn Asp Phe Ile35 40 45 50AAG GCT ATT GGT GGT CTA ATC ATT GTT GGG ACT TGC ATT TAC GCC TAT 250Lys Ala Ile Gly Gly Leu Ile Ile Val Gly Thr Cys Ile Tyr Ala Tyr
55 60 65AAA AAT TGG GAC AGG CTT GGA GAA ATT GGT TGG AAA TGC GTT GGG ATT 298Lys Asn Trp Asp Arg Leu Gly Glu Ile Gly Trp Lys Cys Val Gly Ile
70 75 80ATC ATT ATA ACC GCT GCT ATT TCT AAT GCT AAA ACT TTA AGT CAA TGG346Ile Ile Ile Thr Ala Ala Ile Ser Asn Ala Lys Thr Leu Ser Gln Trp
85 90 95TTA TTT TAGATGGCAT TGCATATTGT TTGTGTTGAA AGTATCAACA TTAGA 397Leu Phe
100
(2) Sequence 112 data:
(i) sequence characteristics:
(A) length: 100 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 112: met Lys Thr Lys His Lys Gly Ile Arg Met Phe Lys Gln Ile Arg Arg 151015 Met Met Ser Leu Ala Ile Leu Met Pro Ser Phe Leu Leu Ala Ala Pro
20 25 30Asp Tyr Lys Gln Lys Phe Thr Gln Ile Leu Asp Phe Ile Ser Asn Asp
35 40 45Phe Ile Lys Ala Ile Gly Gly Leu Ile Ile Val Gly Thr Cys Ile Tyr
50 55 60Ala Tyr Lys Asn Trp Asp Arg Leu Gly Glu Ile Gly Trp Lys Cys Val65 70 75 80Gly Ile Ile Ile Ile Thr Ala Ala Ile Ser Asn Ala Lys Thr Leu Ser
85 90 95Gln Trp Leu Phe
100
(2) Sequence 113 data:
(i) sequence characteristics:
(A) length: 367bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...318
(D) Other information:
(xi) Description of the sequence: sequence 113: CTTGCCAATC CCTTCAATAT CCACCGAATT GATGCCATGC TCAATTAAAA A ATG ATC 57
Met Ile
1CAA AGC GAC GCT GTC TTT AAG ATA AAT TTC TGT CTT GCC CTT CTT GTA 105Gln Ser Asp Ala Val Phe Lys Ile Asn Phe Cys Leu Ala Leu Leu Val
5 10 15TTT GTA AAG AGG GGC TTG AGC GAT ATA AAC ATG CCC TTG TTC AAT CAG 153Phe Val Lys Arg Gly Leu Ser Asp Ile Asn Met Pro Leu Phe Asn Gln
20 25 30CGG GCG CAA ATA ACG ATA GAA AAA AGT CAT CAG CAA GGT TTG GAT ATG 201Arg Ala Gln Ile Thr Ile Glu Lys Ser His Gln Gln Gly Leu Asp Met35 40 45 50GCT CCC ATC CAC ATC AGC ATC GGT CAT GAT AAT GAT TTT ATG ATA GCG 249Ala Pro Ile His Ile Ser Ile Gly His Asp Asn Asp Phe Met Ile Ala
55 60 65CAA TCT TTC TAT ATC AAA ACT CTC TTG AAT GCC GCA CCC AAA AGC CGT 297Gln Ser Phe Tyr Ile Lys Thr Leu Leu Asn Ala Ala Pro Lys Ser Arg
70 75 80GAT CAT GTT TTT AAT TTC TTC TGATTTTAGG ATTTTTGATA AATGGCTTTT TTCC 352Asp His Val Phe Asn Phe Phe
85ACATTTAAAA TCTTA 367
(2) Sequence 114 data:
(i) sequence characteristics:
(A) length: 89 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 114: met Ile Gln Ser Asp Ala Val Phe Lys Ile Asn Phe Cys Leu Ala Leu 151015 Leu Val Phe Val Lys Arg Gly Leu Ser Asp Ile Asn Met Pro Leu Phe
20 25 30Asn Gln Arg Ala Gln Ile Thr Ile Glu Lys Ser His Gln Gln Gly Leu
35 40 45Asp Met Ala Pro Ile His Ile Ser Ile Gly His Asp Asn Asp Phe Met
50 55 60Ile Ala Gln Ser Phe Tyr Ile Lys Thr Leu Leu Asn Ala Ala Pro Lys65 70 75 80Ser Arg Asp His Val Phe Asn Phe Phe
85
(2) Sequence 115 data:
(i) sequence characteristics:
(A) length: 386bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 54...344
(D) Other information:
(xi) Descriptionof the sequence: sequence 115: TAAAAAGCAC TTTAGAGAGA TTTACGAAAG TGTTTTGAAG CGAAGAATGT CTG ATG 56
Met
1ATT ATC TTT GGA AAA GAT TAC CTA TCT ACA GAC TTG CAA AAT AGC GCT 104Ile Ile Phe Gly Lys Asp Tyr Leu Ser Thr Asp Leu Gln Asn Ser Ala
5 10 15AAA GAT ATT CTT CTC ATC GCT TCG CAA ATT CTC AAA GAA AGA CTT TTT 152Lys Asp Ile Leu Leu Ile Ala Ser Gln Ile Leu Lys Glu Arg Leu Phe
20 25 30GCC CAC AAA AAT GAG ATT TTC TTT TGC CCT AGA AAT AGC TAC ATT CAA 200Ala His Lys Asn Glu Ile Phe Phe Cys Pro Arg Asn Ser Tyr Ile Gln
35 40 45GCG TTT AGA ATC TAT CAA GAA AGA AAG ATT ACC ATA AGT TTT CAC GGT 248Ala Phe Arg Ile Tyr Gln Glu Arg Lys Ile Thr Ile Ser Phe His Gly50 55 60 65GGA ATA AAT AAT AAT ATC TGC CTT CTC GCC TTG AAA GGC ATC CAC AGT 296Gly Ile Asn Asn Asn Ile Cys Leu Leu Ala Leu Lys Gly Tle His Ser
70 75 80GTC TAT TTT GAG CTC ATC AAA ATT CTT GAA GCC GTA TTT TTC CAC TTC T 345Val Tyr Phe Glu Leu Ile Lys Ile Leu Glu Ala Val Phe Phe His Phe
85 90 95GATCGCAAGC ATCTTTTTTG GGCATTATAA GGTGTGATAA T 386
(2) Sequence 116 data:
(i) sequence characteristics:
(A) length: 97 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 116: met Ile Ile Phe Gly Lys Asp Tyr Leu Ser Thr Asp Leu Gln Asn Ser 151015 Ala Lys Asp Ile Leu Leu Ile Ala Ser Gln Ile Leu Lys Glu Arg Leu
20 25 30Phe Ala His Lys Asn Glu Ile Phe Phe Cys Pro Arg Asn Ser Tyr Ile
35 40 45Gln Ala Phe Arg Ile Tyr Gln Glu Arg Lys Ile Thr Ile Ser Phe His
50 55 60Gly Gly Ile Asn Asn Asn Ile Cys Leu Leu Ala Leu Lys Gly Ile His65 70 75 80Ser Val Tyr Phe Glu Leu Ile Lys Ile Leu Glu Ala Val Phe Phe His
85 90 95Phe
(2) Sequence 117 data:
(i) sequence characteristics:
(A) length: 569bp by
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 55...516
(D) Other information:
(xi) Description of the sequence: sequence 117: GCGGTTTGGA TCTTCATTAA AAATTCGTTG CTCACCCCTG GGTTATAAGC TTGA GCT 57
Ala
1TCA GAA GTG GCC CCC TCA GAG GTT TTG TTG GAT TCT TCT TGC TTG TCT 105Ser Glu Val Ala Pro Ser Glu Val Leu Leu Asp Ser Ser Cys Leu Ser
5 10 15TTT TCT TTG ACT ATA TCC TTA GTT GTT ACT TGT TTA GGA GCG CTT TTT 153Phe Ser Leu Thr Ile Ser Leu Val Val Thr Cys Leu Gly Ala Leu Phe
20 25 30TCT TTA GCT TCC TCT TTA GCT TCT TCT TTT TTG GGC TCT TCT TTA GGC 201Ser Leu Ala Ser Ser Leu Ala Ser Ser Phe Leu Gly Ser Ser Leu Gly
35 40 45TCT TCT TTT TTA ACC TCT TCA ACT TTA GGC TCA GGC TTA GGC TCG GGT 249Ser Ser Phe Leu Thr Ser Ser Thr Leu Gly Ser Gly Leu Gly Ser Gly50 55 60 65TTT GGT TCA GGT TTG GGT TCA GGC TTA GGT TTT GGT TTT GGC TTT GGC 297Phe Gly Ser Gly Leu Gly Ser Gly Leu Gly Phe Gly Phe Gly Phe Gly
70 75 80TTG GGT TTA GGC TTA GGT TTA GGC TTT GTA ACC TCC TTT TTG GGT TCT 345Leu Gly Leu Gly Leu Gly Leu Gly Phe Val Thr Ser Phe Leu Gly Ser
85 90 95TCT TTT TTT GGC TCT TCT TTC TTG GGT TTT TCT TTA GGC TCT TCT TTG 393Ser Phe Phe Gly Ser Ser Phe Leu Gly Phe Ser Leu Gly Ser Ser Leu
100 105 110GGT TTA GCC GAC TCA GCA TTA GTC TTT GTA TTG GAA TTA GTG TTG ATG 441Gly Leu Ala Asp Ser Ala Leu Val Phe Val Leu Glu Leu Val Leu Met
115 120 125CTG GCT AAA CTC ATG GTA ACC TTA GTG GTC CCG GCT TGC GCT AAA GGC 489Leu Ala Lys Leu Met Val Thr Leu Val Val Pro Ala Cys Ala Lys Gly130 135 140 145TCT GGG GCG TCT TCG CGC AGT AAA AAA TAGCCAAACC CTATAGCGTA TAGGGCA 543Ser Gly Ala Ser Ser Arg Ser Lys Lys
150AAAGAGATTA AAAAGCTAAC ACTCGT 569
(2) Sequence 118 data:
(i) sequence characteristics:
(A) length: 154 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 118: ala Ser Glu Val Ala Pro Ser Glu Val Leu Leu Asp Ser Ser Cys Leu 151015 Ser Phe Ser Leu Thr Ile Ser Leu Val Val Thr Cys Leu Gly Ala Leu
20 25 30Phe Ser Leu Ala Ser Ser Leu Ala Ser Ser Phe Leu Gly Ser Ser Leu
35 40 45Gly Ser Ser Phe Leu Thr Ser Ser Thr Leu Gly Ser Gly Leu Gly Ser
50 55 60Gly Phe Gly Ser Gly Leu Gly Ser Gly Leu Gly Phe Gly Phe Gly Phe65 70 75 80Gly Leu Gly Leu Gly Leu Gly Leu Gly Phe Val Thr Ser Phe Leu Gly
85 90 95Ser Ser Phe Phe Gly Ser Ser Phe Leu Gly Phe Ser Leu Gly Ser Ser
100 105 110Leu Gly Leu Ala Asp Ser Ala Leu Val Phe Val Leu Glu Leu Val Leu
115 120 125Met Leu Ala Lys Leu Met Val Thr Leu Val Val Pro Ala Cys Ala Lys
130 135 140Gly Ser Gly Ala Ser Ser Arg Ser Lys Lys145 150
(2) Sequence 119 data:
(i) sequence characteristics:
(A) length: 359bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 77...310
(D) Other information:
(xi) Description of the sequence: sequence 119: CCCCACAAAT CCTAGCGATA GTGAAATGCC CTAATTCATG GACAAAGATT AAAAACGCCA 60GCATCAAAAC CGCTAC AAT GAA CAT CAT ACC CCT GCA GGC TCT TTG GTG TTA 112
Asn Glu His His Thr Pro Ala Gly Ser Leu Val Leu
1 5 10GGA TCT TTT ATC ATC GGC TCT TTT AAA GGC GTG GGT GCT ATA GGG GGC 160Gly Ser Phe Ile Ile Gly Ser Phe Lys Gly Val Gly Ala Ile Gly Gly
15 20 25GTG GGT GCT GTG GTT TTT GGG ATT TCT TTA TTT TCT TTT GGG GGT TTT 208Val Gly Ala Val Val Phe Gly Ile Ser Leu Phe Ser Phe Gly Gly Phe
30 35 40TGC CAC AAC TCT GTC AAA GCC GCC GCT TTT TTA GGA TCC ATT TTG GCT 256Cys His Asn Ser Val Lys Ala Ala Ala Phe Leu Gly Ser Ile Leu Ala45 50 55 60AAA ATT TTA CCG AGT TCT TGG GGT TTT AGC GCC ATT AAA ATT TCT AAT 304Lys Ile Leu Pro Ser Ser Trp Gly Phe Ser Ala Ile Lys Ile Ser Asn
65 70 75GCG TTT TGAGTGGGTA AATTTTCTAA AATCAGAGCC GATTTAGAAT CTTTCATTT 359Ala Phe
(2) Sequence 120 data:
(i) sequence characteristics:
(A) length: 78 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 120: asn Glu His His Thr Pro Ala Gly Ser Leu Val Leu Gly Ser Phe Ile 151015 Ile Gly Ser Phe Lys Gly Val Gly Ala Ile Gly Gly Val Gly Ala Val
20 25 30Val Phe Gly Ile Ser Leu Phe Ser Phe Gly Gly Phe Cys His Asn Ser
35 40 45Val Lys Ala Ala Ala Phe Leu Gly Ser Ile Leu Ala Lys Ile Leu Pro
50 55 60Ser Ser Trp Gly Phe Ser Ala Ile Lys Ile Ser Asn Ala Phe65 70 75
(2) Sequence 121 data:
(i) sequence characteristics:
(A) length: 1051bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...998
(D) Other information:
(xi) Description of the sequence: sequence 121: GGGTTTTGTG AATGACGACT AAAAGAGTGA ATACTGCCAC AAACAAGATA ATG ACA 56
Met Thr
1TTA AAT ACT TTC TTG GAT ACA TGT TTT CTT TTA TTC ATC AGT ATT CTT 104Leu Asn Thr Phe Leu Asp Thr Cys Phe Leu Leu Phe Ile Ser Ile Leu
5 10 15TTT TAT TTA AGT ATA CCA ATT TAT CCT AAC AAA GTG GTG GTT GTC CCG 152Phe Tyr Leu Ser Ile Pro Ile Tyr Pro Asn Lys Val Val Val Val Pro
20 25 30CAA GGT TCG CTC AAA AAA GTG TTT TTT TCT TTA AAA GAG CAA GGC GTG 200Gln Gly Ser Leu Lys Lys Val Phe Phe Ser Leu Lys Glu Gln Gly Val35 40 45 50GAT ATG AAC GCT TTG GAT TTG CTT TTT TTA CGC CTG ATG GGC ATG CCT 248Asp Met Asn Ala Leu Asp Leu Leu Phe Leu Arg Leu Met Gly Met Pro
55 60 65AAA AAA GGT TAT ATT GAT ATG GGC GAT GGG GCT TTA AGG AAG GGG GAT 296Lys Lys Gly Tyr Ile Asp Met Gly Asp Gly Ala Leu Arg Lys Gly Asp
70 75 80TTT TTA GTC CGT TTG ATT AAG GCA AAA GCG GCA CAA AAA AGT GCG ACT 344Phe Leu Val Arg Leu Ile Lys Ala Lys Ala Ala Gln Lys Ser Ala Thr
85 90 95CTA ATC CCT GGG GAA AGC CGC TAT TTT TTC ACG CAA ATT TTG AGC GAG 392Leu Ile Pro Gly Glu Ser Arg Tyr Phe Phe Thr Gln Ile Leu Ser Glu
100 105 110ACT TAC CAA CTA GAA ACA AGC GAT CTC AAT CAG GCT TAT GAA AGC ATC 440Thr Tyr Gln Leu Glu Thr Ser Asp Leu Asn Gln Ala Tyr Glu Ser Ile115 120 125 130GCT CCA CGA TTG AAT GGC GAA GTG ATA GAA GAT GGG GTG ATA TGG CCA 488Ala Pro Arg Leu Asn Gly Glu Val Ile Glu Asp Gly Val Ile Trp Pro
135 140 145GAC ACT TAT CAT TTG CCT TTA GGG GAG GAC GCT TTT AAA ATC ATG CAA 536Asp Thr Tyr His Leu Pro Leu Gly Glu Asp Ala Phe Lys Ile Met Gln
150 155 160ACT TTG ATT GGT CAA TCC ATG AAA AAA CAC GAA GCC TTA AGC AAA CAA 584Thr Leu Ile Gly Gln Ser Met Lys Lys His Glu Ala Leu Ser Lys Gln
165 170 175TGG CTT GGA TAC TAC CAT AAA GAA GAG TGG TTT GAA AAA ATC ATT CTC 632Trp Leu Gly Tyr Tyr His Lys Glu Glu Trp Phe Glu Lys Ile Ile Leu
180 185 190GCT TCT ATT GTG CAA AAA GAA GCC GCT AAT GTT GAA GAA ATG CCC TTG 680Ala Ser Ile Val Gln Lys Glu Ala Ala Asn Val Glu Glu Met Pro Leu195 200 205 210ATT GCG AGC GTG ATT TTT AAC CGC TTG AAA AAA GGC ATG CCT TTA CAA 728Ile Ala Ser Val Ile Phe Asn Arg Leu Lys Lys Gly Met Pro Leu Gln
215 220 225ATG GAT GGG GCT TTG AAT TAT CAG GAA TTT TCA CAC GCT AAA GTA ACC 776Met Asp Gly Ala Leu Asn Tyr Gln Glu Phe Ser His Ala Lys Val Thr
230 235 240AAA GAG CGC ATT AAA ACC GAT AAC ACC CCC TAC AAT ACC TAT AAA TTT 824Lys Glu Arg Ile Lys Thr Asp Asn Thr Pro Tyr Asn Thr Tyr Lys Phe
245 250 255AAG GGT TTG CCT AAA AAT CCT GTA GGG AGC GTG AGC CTA GAA GCG ATT 872Lys Gly Leu Pro Lys Asn Pro Val Gly Ser Val Ser Leu Glu Ala Ile
260 265 270AGA GCC GTG ATC TTC CCT AAA AAA ACG GAT TTC TTG TAT TTT GTG AAA 920Arg Ala Val Ile Phe Pro Lys Lys Thr Asp Phe Leu Tyr Phe Val Lys275 280 285 290ATG CCG GAT AAA AAA CAT GCT TTC AGC GCG ACT TATAAA GAG CAT TTA 968Met Pro Asp Lys Lys His Ala Phe Ser Ala Thr Tyr Lys Glu His Leu
295 300 305AAA AAC ATT AAT CTT TCT AAT AAT CAT TTT TAAGATTAAG GTAAATGGGG CGT 1021Lys Asn Ile Asn Leu Ser Asn Asn His Phe
310 315TTTTTCTTTT GAATTGAGTA AAAAGTGTTT 1051
(2) Sequence 122 data:
(i) sequence characteristics:
(A) length: 316 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 122: met Thr Leu Asn Thr Phe Leu Asp Thr Cys Phe Leu Leu Phe Ile Ser 151015 Ile Leu Phe Tyr Leu Ser Ile Pro Ile Tyr Pro Asn Lys Val Val Val
20 25 30Val Pro Gln Gly Ser Leu Lys Lys Val Phe Phe Ser Leu Lys Glu Gln
35 40 45Gly Val Asp Met Asn Ala Leu Asp Leu Leu Phe Leu Arg Leu Met Gly
50 55 60Met Pro Lys Lys Gly Tyr Ile Asp Met Gly Asp Gly Ala Leu Arg Lys65 70 75 80Gly Asp Phe Leu Val Arg Leu Ile Lys Ala Lys Ala Ala Gln Lys Ser
85 90 95Ala Thr Leu Ile Pro Gly Glu Ser Arg Tyr Phe Phe Thr Gln Ile Leu
100 105 110Ser Glu Thr Tyr Gln Leu Glu Thr Ser Asp Leu Asn Gln Ala Tyr Glu
115 120 125Ser Ile Ala Pro Arg Leu Asn Gly Glu Val Ile Glu Asp Gly Val Ile
130 135 140Trp Pro Asp Thr Tyr His Leu Pro Leu Gly Glu Asp Ala Phe Lys Ile145 150 155 160Met Gln Thr Leu Ile Gly Gln Ser Met Lys Lys His Glu Ala Leu Ser
165 170 175Lys Gln Trp Leu Gly Tyr Tyr His Lys Glu Glu Trp Phe Glu Lys Ile
180 185 190Ile Leu Ala Ser Ile Val Gln Lys Glu Ala Ala Asn Val Glu Glu Met
195 200 205Pro Leu Ile Ala Ser Val Ile Phe Asn Arg Leu Lys Lys Gly Met Pro
210 215 220Leu Gln Met Asp Gly Ala Leu Asn Tyr Gln Glu Phe Ser His Ala Lys225 230 235 240Val Thr Lys Glu Arg Ile Lys Thr Asp Asn Thr Pro Tyr Asn Thr Tyr
245 250 255Lys Phe Lys Gly Leu Pro Lys Asn Pro Val Gly Ser Val Ser Leu Glu
260 265 270Ala Ile Arg Ala Val Ile Phe Pro Lys Lys Thr Asp Phe Leu Tyr Phe
275 280 285Val Lys Met Pro Asp Lys Lys His Ala Phe Ser Ala Thr Tyr Lys Glu
290 295 300His Leu Lys Asn Ile Asn Leu Ser Asn Asn His Phe305 310 315
(2) Sequence 123 data:
(i) sequence characteristics:
(A) length: 637bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...584
(D) Other information:
(xi) Description of the sequence: sequence 123: GAAAGTTCGG GGGCGGATTC TATGATTAAT GGCTATGGTT ATACCAAAGA ATG AGT 56
Met Ser
1CAA AAA ATC CTA ATT CTA GGT ATT GGC AAT ATC CTT TTT GGC GAT GAA 104Gln Lys Ile Leu Ile Leu Gly Ile Gly Asn Ile Leu Phe Gly Asp Glu
5 10 15GGG ATT GGG GTG CAT TTA GCC CAC TAC CTC AAA AAA AAT TTT TCT TTT 152Gly Ile Gly Val His Leu Ala His Tyr Leu Lys Lys Asn Phe Ser Phe
20 25 30TTC CCT AGC GTG GAT ATT ATA GAT GGG GGG ACA ATG GCC CAG CAG CTC 200Phe Pro Ser Val Asp Ile Ile Asp Gly Gly Thr Met Ala Gln Gln Leu35 40 45 50ATT CCT TTA ATC ACT TCG TAT GAA AAG GTT TTG ATT TTG GAT TGC GTG 248Ile Pro Leu Ile Thr Ser Tyr Glu Lys Val Leu Ile Leu Asp Cys Val
55 60 65AGC GCT GAA GGC GTT GAG ATA GGA TCA GTC TAT GCT TTT GAT TTT AAG 296Ser Ala Glu Gly Val Glu Ile Gly Ser Val Tyr Ala Phe Asp Phe Lys
70 75 80GAC GCT CCT AAA GAA ATC ACA TGG GCT GGG AGC GCT CAT GAA GTG GAA 344Asp Ala Pro Lys Glu Ile Thr Trp Ala Gly Ser Ala His Glu Val Glu
85 90 95ATG CTA CACACT TTA AGG CTC ACG GAG TTT TTA GGG GAT TTG CCT AAA 392Met Leu His Thr Leu Arg Leu Thr Glu Phe Leu Gly Asp Leu Pro Lys
100 105 110ACT TTT ATC GTG GGG CTT GTG CCT TTT GTG ATA GGG AGC GAG ACC ACT 440Thr Phe Ile Val Gly Leu Val Pro Phe Val Ile Gly Ser Glu Thr Thr115 120 125 130TTC AAG CTT TCA AGC AAA ATT TTA AAC GCT TTA GAA ACC GCC TTA AAA 488Phe Lys Leu Ser Ser Lys Ile Leu Asn Ala Leu Glu Thr Ala Leu Lys
135 140 145GCC ATA GAA ACC CAA CTC AAC GCA TGG GGG GTT AAA ATG CAA CGC ACC 536Ala Ile Glu Thr Gln Leu Asn Ala Trp Gly Val Lys Met Gln Arg Thr
150 155 160GAT CAT ATC GCT TTA GAA TGT ATC GCT GAA CTT TCT TAT AAG GGT TTT T 585Asp His Ile Ala Leu Glu Cys Ile Ala Glu Leu Ser Tyr Lys Gly Phe
165 170 175GAATTGGTTT TTGTTTTTCT TTTTAAATGC GTTAATGAAG AAACAAGCCT GA 637
(2) Sequence 124 data:
(i) sequence characteristics:
(A) length: 178 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 124: met Ser Gln Lys Ile Leu Ile Leu Gly Ile Gly Asn Ile Leu Phe Gly 151015 Asp Glu Gly Ile Gly Val His Leu Ala His Tyr Leu Lys Lys Asn Phe
20 25 30Ser Phe Phe Pro Ser Val Asp Ile Ile Asp Gly Gly Thr Met Ala Gln
35 40 45Gln Leu Ile Pro Leu Ile Thr Ser Tyr Glu Lys Val Leu Ile Leu Asp
50 55 60Cys Val Ser Ala Glu Gly Val Glu Ile Gly Ser Val Tyr Ala Phe Asp65 70 75 80Phe Lys Asp Ala Pro Lys Glu Ile Thr Trp Ala Gly Ser Ala His Glu
85 90 95Val Glu Met Leu His Thr Leu Arg Leu Thr Glu Phe Leu Gly Asp Leu
100 105 110Pro Lys Thr Phe Ile Val Gly Leu Val Pro Phe Val Ile Gly Ser Glu
115 120 125Thr Thr Phe Lys Leu Ser Ser Lys Ile Leu Asn Ala Leu Glu Thr Ala
130 135 140Leu Lys Ala Ile Glu Thr Gln Leu Asn Ala Trp Gly Val Lys Met Gln145 150 155 160Arg Thr Asp His Ile Ala Leu Glu Cys Ile Ala Glu Leu Ser Tyr Lys
165 170 175Gly Phe
(2) Sequence 125 data:
(i) sequence characteristics:
(A) length: 214bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...161
(D) Other information:
(xi) Description of the sequence: sequence 125: GCATTGCTAA TTTGGGAATA CTTGTTTATG CCAGTGAAAT AGGAGCGGCT ATG ATG 56
Met Met
1TGG CGT AGT CTC ARG GTG GCT TTT ACG ATC ACT GAT ATT AGT AAA ACC 104Trp Arg Ser Leu Xaa Val Ala Phe Thr Ile Thr Asp Ile Ser Lys Thr
5 10 15TTT CAA TCC CAG CCT AAG CAC CAT CAA ATC GGC ACT TTA GAA TTG AAT 152Phe Gln Ser Gln Pro Lys His His Gln Ile Gly Thr Leu Glu Leu Asn
20 25 30TTC GCC TTT TGATTTAATA TCAGTTTAAT ATTTTTCTTC CTATATGATA TTTATATGA 210Phe Ala Phe35TATT 214
(2) Sequence 126 data:
(i) sequence characteristics:
(A) length: 37 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 126: met Met Trp Arg Ser Leu Xaa Val Ala Phe Thr Ile Thr Asp Ile Ser 151015 Lys Thr Phe Gln Ser Gln Pro Lys His His Gln Ile Gly Thr Leu Glu
20 25 30Leu Asn Phe Ala Phe
35
(2) Sequence 127 data:
(i) sequence characteristics:
(A) length: 1576bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1523
(D) Other information:
(xi) Description of the sequence: sequence 127: CTGTATTCGC TTCTGTGGAT TACTACCCTC AAAGAAAAGA AAGCCACAGA ATG AAC 56
Met Asn
1ACC ACC ATC TTA GAA GCT TAT GCG GCT GAG CCA AGC AGG CAA ACC CTC 104Thr Thr Ile Leu Glu Ala Tyr Ala Ala Glu Pro Ser Arg Gln Thr Leu
5 10 15TCT AAA GTC AGC AAC CGA TTC AAA GAG CAT GGC GCT AAA TTT GAT CTT 152Ser Lys Val Ser Asn Arg Phe Lys Glu His Gly Ala Lys Phe Asp Leu
20 25 30CGT GTG ATG GCA ACG CAT GGA GGC ACC ATT AGT TGG AAA GCT AAA GAA 200Arg Val Met Ala Thr His Gly Gly Thr Ile Ser Trp Lys Ala Lys Glu35 40 45 50CTC GCT AGG ACT ATT GTG AGC GGC CCT ATT GGA GGC GTG ATT GGA TCT 248Leu Ala Arg Thr Ile Val Ser Gly Pro Ile Gly Gly Val Ile Gly Ser
55 60 65AAA TTG CTA GGC GAA ACG CTT GGT TAT GAC AAT ATT GCA TGC AGT GAT 296Lys Leu Leu Gly Glu Thr Leu Gly Tyr Asp Asn Ile Ala Cys Ser Asp
70 75 80ATT GGK GGC ACG AGC TTT GAT ATG GCG CTT ATC GTT AAG AGC AAT TTT 344Ile Xaa Gly Thr Ser Phe Asp Met Ala Leu Ile Val Lys Ser Asn Phe
85 90 95AAC ATC GCT TCT GAC CCT GAT ATG GCA CGC CTT GTT TTA TCT CTA CCG 392Asn Ile AlaSer Asp Pro Asp Met Ala Arg Leu Val Leu Ser Leu Pro
100 105 110CTT GTG GCT ATG GAT TCT GTT GGC GCA GGT GCT GGG AGT TTT GTG CGC 440Leu Val Ala Met Asp Ser Val Gly Ala Gly Ala Gly Ser Phe Val Arg115 120 125 130ATT GAT CCA CAC AGC CGA TCT GTC AAA CTA GGG CCT GAC AGC GCG GGG 488Ile Asp Pro His Ser Arg Ser Val Lys Leu Gly Pro Asp Ser Ala Gly
135 140 145TAT AGA GTT GGC ACT TGT TGG AAA GAC AGC GGG TTA GAC ACG GTT TCA 536Tyr Arg Val Gly Thr Cys Trp Lys Asp Ser Gly Leu Asp Thr Val Ser
150 155 160GTA ACC GAT TGC CAT ATT GTT TTA GGC TAT TTG AAC CCG GAT AAT TTC 584Val Thr Asp Cys His Ile Val Leu Gly Tyr Leu Asn Pro Asp Asn Phe
165 170 175TTA GGC GGT TTG ATC AAA TTA GAT GTG GAT AGG GCT AAA AAA CAC ATT 632Leu Gly Gly Leu Ile Lys Leu Asp Val Asp Arg Ala Lys Lys His Ile
180 185 190AAA GAA CAA ATC GCT GAT CCG CTA GGC ATT AGC GTA GAA GAT GCG GCT 680Lys Glu Gln Ile Ala Asp Pro Leu Gly Ile Ser Val Glu Asp Ala Ala195 200 205 210GCT GGT GTG ATT GAA TTG CTT GAT TTG GAG CTT AAA GAA TAC TTG CGA 728Ala Gly Val Ile Glu Leu Leu Asp Leu Glu Leu Lys Glu Tyr Leu Arg
215 220 225TCC AAC ATT AGC GCT AAA GGG TAT AGC CCA TCT GAT TTT GTG TGC TTT 776Ser Asn Ile Ser Ala Lys Gly Tyr Ser Pro Ser Asp Phe Val Cys Phe
230 235 240TCA TAT GGT GGC GCA GGA CCT GTG CAT ACC TAT GGC TAT ACA GAA GGA 824Ser Tyr Gly Gly Ala Gly Pro Val His Thr Tyr Gly Tyr Thr Glu Gly
245250 255TTA GGG TTT AAG GAT GTG GTA GTG CCT GCG TGG GCG GCT GGA TTT AGC 872Leu Gly Phe Lys Asp Val Val Val Pro Ala Trp Ala Ala Gly Phe Ser
260 265 270GCT TTT GGT TGT GCT TGC GCT GAT TTT GAA TAC AGA TAC GAC AAG AGC 920Ala Phe Gly Cys Ala Cys Ala Asp Phe Glu Tyr Arg Tyr Asp Lys Ser275 280 285 290GTG GAT ATT GCC ATT CCG CAG TAT TCT TCA GAC AAG TCA AAA ATA GAC 968Val Asp Ile Ala Ile Pro Gln Tyr Ser Ser Asp Lys Ser Lys Ile Asp
295 300 305GCA TGC AAA ATC ATT CAA GAC GCA TGG GAT GAA TTG ACT TTG AAA GTG 1016Ala Cys Lys Ile Ile Gln Asp Ala Trp Asp Glu Leu Thr Leu Lys Val
310 315 320ATT GAA GAG TTC AAG ATC AAT GGA TTT TCT CAA AAA GAT GTG ATC TTA 1064Ile Glu Glu Phe Lys Ile Asn Gly Phe Ser Gln Lys Asp Val Ile Leu
325 330 335AGA CCT GGA TAC AGG ATG CAG TAT ATG GGG CAA TTG AAT GAT TTA GAG 1112Arg Pro Gly Tyr Arg Met Gln Tyr Met Gly Gln Leu Asn Asp Leu Glu
340 345 350ATC ACT TCT CCT GTG TCA AAA GCT GCA ACC GTG GCT GAT TGG GAA GAG 1160Ile Thr Ser Pro Val Ser Lys Ala Ala Ser Val Ala Asp Trp Glu Glu355 360 365 370ATT GTC AAA GAA TAT GAA AAA ACC TAC GCT CGC GTT TAT TCT GAA TCA 1208Ile Val Lys Glu Tyr Glu Lys Thr Tyr Ala Arg Val Tyr Ser Glu Ser
375 380 385GCG TGT TCT CCA GAG CTT GGT TTT AGC GTG ACT GGC GTG ATC ATG CGT 1256Ala Cys Ser Pro Glu Leu Gly Phe Ser Val Thr Gly Val Ile Met Arg
390 395 400GGT GTT GTG GCT ACG CAA AAA CCT GTG ATT CCG GTT GAA AAA GAG CAT1304Gly Val Val Ala Thr Gln Lys Pro Val Ile Pro Val Glu Lys Glu His
405 410 415GGT GCT ACG CCC CCA AAA GAA GCC AAA ATA GGC GTT AGA AAA TTC TAT 1352Gly Ala Thr Pro Pro Lys Glu Ala Lys Ile Gly Val Arg Lys Phe Tyr
420 425 430CGG CAT AAA AAA TGG GTG GAT GCA GAT GTG TGG CAA ATG GAA AAA TTA 1400Arg His Lys Lys Trp Val Asp Ala Asp Val Trp Gln Met Glu Lys Leu435 440 445 450CTG CCT GGA AAT GAA GTC ATA GGA CCT GCG ATC GTG GAA TCA GAT GCG 1448Leu Pro Gly Asn Glu Val Ile Gly Pro Ala Ile Val Glu Ser Asp Ala
455 460 465ACC ACT TTC GTG ATA CCC AAA GGC TTT GCG ACA AGA CTA GAC AAA CAC 1496Thr Thr Phe Val Ile Pro Lys Gly Phe Ala Thr Arg Leu Asp Lys His
470 475 480CGA TTG TTC CAC TTG AAA GAA ATT AAA TAAAGGAGTT CAAAATGGCA AATTTAT 1550Arg Leu Phe His Leu Lys Glu Ile Lys
485 490TGAAAAACGG CAAAACTTTA AAACAA 1576
(2) Sequence 128:
(i) sequence characteristics:
(A) length: 491 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 128: met Asn Thr Thr Ile Leu Glu Ala Tyr Ala Ala Glu Pro Ser Arg Gln 151015 Thr Leu Ser Lys Val Ser Asn Arg Phe Lys Glu His Gly Ala Lys Phe
2025 30Asp Leu Arg Val Met Ala Thr His Gly Gly Thr Ile Ser Trp Lys Ala
35 40 45Lys Glu Leu Ala Arg Thr Ile Val Ser Gly Pro Ile Gly Gly Val Ile
50 55 60Gly Ser Lys Leu Leu Gly Glu Thr Leu Gly Tyr Asp Asn Ile Ala Cys65 70 75 80Ser Asp Ile Xaa Gly Thr Ser Phe Asp Met Ala Leu Ile Val Lys Ser
85 90 95Asn Phe Asn Ile Ala Ser Asp Pro Asp Met Ala Arg Leu Val Leu Ser
100 105 110Leu Pro Leu Val Ala Met Asp Ser Val Gly Ala Gly Ala Gly Ser Phe
115 120 125Val Arg Ile Asp Pro His Ser Arg Ser Val Lys Leu Gly Pro Asp Ser
130 135 140Ala Gly Tyr Arg Val Gly Thr Cys Trp Lys Asp Ser Gly Leu Asp Thr145 150 155 160Val Ser Val Thr Asp Cys His Ile Val Leu Gly Tyr Leu Asn Pro Asp
165 170 175Asn Phe Leu Gly Gly Leu Ile Lys Leu Asp Val Asp Arg Ala Lys Lys
180 185 190His Ile Lys Glu Gln Ile Ala Asp Pro Leu Gly Ile Ser Val Glu Asp
195 200 205Ala Ala Ala Gly Val Ile Glu Leu Leu Asp Leu Glu Leu Lys Glu Tyr
210 215 220Leu Arg Ser Asn Ile Ser Ala Lys Gly Tyr Ser Pro Ser Asp Phe Val225 230 235 240Cys Phe Ser Tyr Gly Gly Ala Gly Pro Val His Thr Tyr Gly Tyr Thr
245 250 255Glu Gly Leu Gly Phe Lys Asp Val Val Val Pro Ala Trp Ala Ala Gly
260 265 270Phe Ser Ala Phe Gly Cys Ala Cys Ala Asp Phe Glu Tyr Arg Tyr Asp
275 280 285Lys Ser Val Asp Ile Ala Ile Pro Gln Tyr Ser Ser Asp Lys Ser Lys
290 295 300Ile Asp Ala Cys Lys Ile Ile Gln Asp Ala Trp Asp Glu Leu Thr Leu305 310 315 320Lys Val Ile Glu Glu Phe Lys Ile Asn Gly Phe Ser Gln Lys Asp Val
325 330 335Ile Leu Arg Pro Gly Tyr Arg Met Gln Tyr Met Gly Gln Leu Asn Asp
340 345 350Leu Glu Ile Thr Ser Pro Val Ser Lys Ala Ala Ser Val Ala Asp Trp
355 360 365Glu Glu Ile Val Lys Glu Tyr Glu Lys Thr Tyr Ala Arg Val Tyr Ser
370 375 380Glu Ser Ala Cys Ser Pro Glu Leu Gly Phe Ser Val Thr Gly Val Ile385 390 395 400Met Arg Gly Val Val Ala Thr Gln Lys Pro Val Ile Pro Val Glu Lys
405 410 415Glu His Gly Ala Thr Pro Pro Lys Glu Ala Lys Ile Gly Val Arg Lys
420 425 430Phe Tyr Arg His Lys Lys Trp Val Asp Ala Asp Val Trp Gln Met Glu
435 440 445Lys Leu Leu Pro Gly Asn Glu Val Ile Gly Pro Ala Ile Val Glu Ser
450 455 460Asp Ala Thr Thr Phe Val Ile Pro Lys Gly Phe Ala Thr Arg Leu Asp465 470 475 480Lys His Arg Leu Phe His Leu LysGlu Ile Lys
485 490
(2) Sequence 129 data:
(i) sequence characteristics:
(A) length: 303bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...261
(D) Other information:
(xi) Description of the sequence: sequence 129: GTAAGCTAGA GTTTATGCAA AGGGAGATGA GTAGCCTAGA AGCTAAGCAT T ATG ATT 57
Met Ile
1CAG TTA AAA TCA AAT TTG GAT TGG TAC GCA GAT TAT TTG AAT TTT TTA 105Gln Leu Lys Ser Asn Leu Asp Trp Tyr Ala Asp Tyr Leu Asn Phe Leu
5 10 15GAT CGC TTT GGG GAA AAA ATG GAA GAA TCC AAA GAG CGA AAA CAA CTC 153Asp Arg Phe Gly Glu Lys Met Glu Glu Ser Lys Glu Arg Lys Gln Leu
20 25 30CTG ATC GCT TCC CTT GCA CCT CTT GCG GGC TTT GCT GCA AGA ATA TCG 201Leu Ile Ala Ser Leu Ala Pro Leu Ala Gly Phe Ala Ala Arg Ile Ser35 40 45 50CCG GGA TTA TTG AGC TTA TTG GGT TTG ATG CTG GCA ATG GGG TGT GCA 249Pro Gly Leu Leu Ser Leu Leu Gly Leu Met Leu Ala Met Gly Cys Ala
55 60 65AAT TTT TGG ATT TAGAAACCAA TCTGTGCAAG ATTTATGAAT CGCGCCCGTT AA 303Asn Phe Trp Ile
70
(2) Sequence 130 data:
(i) sequence characteristics:
(A) length: 70 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 130: met Ile Gln Leu Lys Ser Asn Leu Asp Trp Tyr Ala Asp Tyr Leu Asn 151015 Phe Leu Asp Arg Phe Gly Glu Lys Met Glu Glu Ser Lys Glu Arg Lys
20 25 30Gln Leu Leu Ile Ala Ser Leu Ala Pro Leu Ala Gly Phe Ala Ala Arg
35 40 45Ile Ser Pro Gly Leu Leu Ser Leu Leu Gly Leu Met Leu Ala Met Gly
50 55 60Cys Ala Asn Phe Trp Ile65 70
(2) Sequence 131 data:
(i) sequence characteristics:
(A) length: 826bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...773
(D) Other information:
(xi) Description of the sequence: sequence 131: TGGCTTAATT GTTAAGCCGG CTAGAAAAAG AGCGTTATTT GCGCCATATC ATG CTA 56
Met Leu
1GAA GAT GTG GGC GAA GAG GGT CAA TTG AAG CTT TTA AAA TCT AGC GTT 104Glu Asp Val Gly Glu Glu Gly Gln Leu Lys Leu Leu Lys Ser Ser Val
5 10 15TTA GTC ATT GGG GCT GGG GGT CTT GGA TCG GCG GTT TTG ATG TAT TTG 152Leu Val Ile Gly Ala Gly Gly Leu Gly Ser Ala Val Leu Met Tyr Leu
20 25 30TGT GCC GCT GGG ATA GGA AAA ATC GGT ATT GTA GAT TTT GAT GTA GTA 200Cys Ala Ala Gly Ile Gly Lys Ile Gly Ile Val Asp Phe Asp Val Val35 40 45 50GAT ATG AGT AAT TTG CAA CGC CAA ATC ATC CAT TCA CAG GAT TTT TTA 248Asp Met Ser Asn Leu Gln Arg Gln Ile Ile His Ser Gln Asp Phe Leu
55 60 65AAC CAA TCT AAA GCC TCT AGC GCG AAA GCG CGC TTA AAA CAA CTC AAT 296Asn Gln Ser Lys Ala Ser Ser Ala Lys Ala Arg Leu Lys Gln Leu Asn
70 75 80GCG GGT ATT GAA ATA GAG GCT TTT GAA GAA CGC TTT AAG GCT CAT AAC 344Ala Gly Ile Glu Ile Glu Ala Phe Glu Glu Arg Phe Lys Ala His Asn
85 90 95GCT CTT TCT CTC ATA GAG CCT TAT GAT TTT ATC ATA GAC GCC ACG GAC 392Ala Leu Ser Leu Ile Glu Pro Tyr Asp Phe Ile Ile Asp Ala Thr Asp
100 105 110AAT TTT AAC GCT AAA TTT TTG ATC AAT GAC GCT TGC GTG TTA GCC CAA 440Asn Phe Asn Ala Lys Phe Leu Ile Asn Asp Ala Cys Val Leu Ala Gln115 120 125 130AAA CCC TAT TCG CAT GCC GGG GTT TTA GAA TAC AGG GGG CAA AGC ATG 488Lys Pro Tyr Ser His Ala Gly Val Leu Glu Tyr Arg Gly Gln Ser Met
135 140 145AGC GTT TTA CCC CAT AGC GCA TGC TTA GCG TGC GTT TTT GAT AAG CCC 536Ser Val Leu Pro His Ser Ala Cys Leu Ala Cys Val Phe Asp Lys Pro
150 155 160CCT AAA AAG GGA TTA AAT CCC ATT TCA GGG CTT TTT GGG GTC TTA CCC 584Pro Lys Lys Gly Leu Asn Pro Ile Ser Gly Leu Phe Gly Val Leu Pro
165 170 175GGA GTT TTA GGG TGT ATC CAA GCG AGC GAA TGC CTT AAA TAT TTT TTA 632Gly Val Leu Gly Cys Ile Gln Ala Ser Glu Cys Leu Lys Tyr Phe Leu
180 185 190GGG TTT GAA ACT TTA CTT ATA AAT ACT TTA CTT ATA GCC GAT ATT AAA 680Gly Phe Glu Thr Leu Leu Ile Asn Thr Leu Leu Ile Ala Asp Ile Lys195 200 205 210ACG ATG GAT TTT AAA AAA ATT CAA GCA CCC AAA AAC CCT GAA TGT AGG 728Thr Met Asp Phe Lys Lys Ile Gln Ala Pro Lys Asn Pro Glu Cys Arg
215 220 225GTT TGT GGC ACG CAT AAA ATC ACG CAT TTA CAG GAT TAT GAA ATT TAGAT 778Val Cys Gly Thr His Lys Ile Thr His Leu Gln Asp Tyr Glu Ile
230 235 240TAAGGGGTAA GTTTTGGATT TATCAACCAT ATTAGGCTTG GTATTGGC 826
(2) Sequence 132 data:
(i) sequence characteristics:
(A) length: 241 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of thesequence: sequence 132: met Leu Glu Asp Val Gly Glu Glu Gly Gln Leu Lys Leu Leu Lys Ser 151015 Ser Val Leu Val Ile Gly Ala Gly Gly Leu Gly Ser Ala Val Leu Met
20 25 30Tyr Leu Cys Ala Ala Gly Ile Gly Lys Ile Gly Ile Val Asp Phe Asp
35 40 45Val Val Asp Met Ser Asn Leu Gln Arg Gln Ile Ile His Ser Gln Asp
50 55 60Phe Leu Asn Gln Ser Lys Ala Ser Ser Ala Lys Ala Arg Leu Lys Gln65 70 75 80Leu Asn Ala Gly Ile Glu Ile Glu Ala Phe Glu Glu Arg Phe Lys Ala
85 90 95His Asn Ala Leu Ser Leu Ile Glu Pro Tyr Asp Phe Ile Ile Asp Ala
100 105 110Thr Asp Asn Phe Asn Ala Lys Phe Leu Ile Asn Asp Ala Cys Val Leu
115 120 125Ala Gln Lys Pro Tyr Ser His Ala Gly Val Leu Glu Tyr Arg Gly Gln
130 135 140Ser Met Ser Val Leu Pro His Ser Ala Cys Leu Ala Cys Val Phe Asp145 150 155 160Lys Pro Pro Lys Lys Gly Leu Asn Pro Ile Ser Gly Leu Phe Gly Val
165 170 175Leu Pro Gly Val Leu Gly Cys Ile Gln Ala Ser Glu Cys Leu Lys Tyr
180 185 190Phe Leu Gly Phe Glu Thr Leu Leu Ile Asn Thr Leu Leu Ile Ala Asp
195 200 205Ile Lys Thr Met Asp Phe Lys Lys Ile Gln Ala Pro Lys Asn Pro Glu
210 215 220Cys Arg Val Cys Gly Thr His Lys Ile Thr His Leu Gln Asp TyrGlu225 230 235 240Ile
(2) Sequence 133 data:
(i) sequence characteristics:
(A) length: 547bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...494
(D) Other information:
(xi) Description of the sequence: sequence 133: AAAATTCATT CTATTTTAGA TAATGAGTTC AATCCCCACA AACAGCAAGA ATG AAT 56
Met Asn
1CGC ATG AAT AAA AAT TAT CTT TTA ATC TTT TTG TTG TTA GCG AGT CTT 104Arg Met Asn Lys Asn Tyr Leu Leu Ile Phe Leu Leu Leu Ala Ser Leu
5 10 15GTT GCT AGA GAG AAG GAC GCT TCT TCA AAC CTT TTT GAT TTG ATT GAT 152Val Ala Arg Glu Lys Asp Ala Ser Ser Asn Leu Phe Asp Leu Ile Asp
20 25 30AAG GGG ATC AAC AGA GAA CAA GAA TTA AAA GAG CAG GAG CAA AAA ACG 200Lys Gly Ile Asn Arg Glu Gln Glu Leu Lys Glu Gln Glu Gln Lys Thr35 40 45 50CGC TTA AAA CTG GCT CAA AGC CCT TTA GTA GCG TTA GAG ATT GTC CCC 248Arg Leu Lys Leu Ala Gln Ser Pro Leu Val Ala Leu Glu Ile Val Pro
55 60 65CAA GAA ACG CCC TAT TTA GAA TGG CAA GGG GCT AGG GAG TCG TAT TAT 296Gln Glu Thr Pro Tyr Leu Glu Trp Gln Gly Ala Arg Glu Ser Tyr Tyr
70 75 80TTA AAG GTG AGC GCT GTA GTG GAG AGC GTG GTT ATC TTA AAA ATT GAC 344Leu Lys Val Ser Ala Val Val Glu Ser Val Val Ile Leu Lys Ile Asp
85 90 95ATC AAT CAA GGG CGT TCT TGC TCG CTC TAC CCC ACG CCT AAA AGC GTT 392Ile Asn Gln Gly Arg Ser Cys Ser Leu Tyr Pro Thr Pro Lys Ser Val
100 105 110TCT TTA GTG AGG AAT CAA AGC GTA GCC TAT GAA ATT TTA TGC GAA AAC 440Ser Leu Val Arg Asn Gln Ser Val Ala Tyr Glu Ile Leu Cys Glu Asn115 120 125 130CAA CCC CTA TGG ATA GAA GTA AGC ACC AAT TTA GGC AAA CGC ACC TTT 488Gln Pro Leu Trp Ile Glu Val Ser Thr Asn Leu Gly Lys Arg Thr Phe
135 140 145CAG TTT TAACCTGCAA CCAACATTAA AGAATGCCTT TAGCATTTTA AAACCCCTTT AT 546Gln PheC 547
(2) Sequence 134 data:
(i) sequence characteristics:
(A) length: 148 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 134: met Asn Arg Met Asn Lys Asn Tyr Leu Leu Ile Phe Leu Leu Leu Ala 151015 Ser Leu Val Ala Arg Glu Lys Asp Ala Ser Ser Asn Leu Phe Asp Leu
20 25 30Ile Asp Lys Gly Ile Asn Arg Glu Gln Glu Leu Lys Glu Gln Glu Gln
35 40 45Lys Thr Arg Leu Lys Leu Ala Gln Ser Pro Leu Val Ala Leu Glu Ile
50 55 60 Val Pro Gln Glu Thr Pro Tyr Leu Glu Trp Gln Gly Ala Arg Glu Ser65 70 75 80Tyr Tyr Leu Lys Val Ser Ala Val Val Glu Ser Val Val Ile Leu Lys
85 90 95Ile Asp Ile Asn Gln Gly Arg Ser Cys Ser Leu Tyr Pro Thr Pro Lys
100 105 110Ser Val Ser Leu Val Arg Asn Gln Ser Val Ala Tyr Glu Ile Leu Cys
115 120 125Glu Asn Gln Pro Leu Trp Ile Glu Val Ser Thr Asn Leu Gly Lys Arg
130 135 140Thr Phe Gln Phe145
(2) Sequence 135 data:
(i) sequence characteristics:
(A) length: 1684bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1631
(D) Other information:
(xi) Description of the sequence: sequence 135: CCTTTCTTTA TTCTCATTGC ATCTTGTGGG ATCATTTTTT TTTTTTATTA ATG CTA 56
Met Leu
1GCT TCC ATC ATC TCA ATT TTA AGG GTT TTT GTT TTG TTA TTC AAC ACG 104Ala Ser IleIle Ser Ile Leu Arg Val Phe Val Leu Leu Phe Asn Thr
5 10 15CCG TTA TTC ATC TTT GCT TTT TTG CCT GTT GGT TTT TTA GGG TAT TTT 152Pro Leu Phe Ile Phe Ala Phe Leu Pro Val Gly Phe Leu Gly Tyr Phe
20 25 30ATC TTG CAA GCT TAT GCT AAA AAT CCC CTG TTC CCT AAA CTA TGG CTA 200Ile Leu Gln Ala Tyr Ala Lys Asn Pro Leu Phe Pro Lys Leu Trp Leu35 40 45 50GTA TTG GCT AGT TTG TTT TTT TAT GCT TTT TGG AAT GTG AAG TAT TTG 248Val Leu Ala Ser Leu Phe Phe Tyr Ala Phe Trp Asn Val Lys Tyr Leu
55 60 65CCC TTA TTG GTT GGC TCT ATT GTT TTT AAT TAT TTT GTG GCT TTG AAA 296Pro Leu Leu Val Gly Ser Ile Val Phe Asn Tyr Phe Val Ala Leu Lys
70 75 80ATC CAT CAA ACC CAG CCA AAT GCA TAT AAA AGA TTA TGG CTT ATT TTG 344Ile His Gln Thr Gln Pro Asn Ala Tyr Lys Arg Leu Trp Leu Ile Leu
85 90 95GGC TTG ATC GCT AAT GTT TCA CTT TTA GGA TTT TTC AAA TAC ACT GAT 392Gly Leu Ile Ala Asn Val Ser Leu Leu Gly Phe Phe Lys Tyr Thr Asp
100 105 110TTT TTC TTA ACC AAT TTC AAT CTA ATA TGG AAG AGC CAT TTT GAA ACC 440Phe Phe Leu Thr Asn Phe Asn Leu Ile Trp Lys Ser His Phe Glu Thr115 120 125 130TTG CAT TTA ATC TTG CCT TTA GCG ATC AGC TTT TTC ACT TTG CAA CAA 488Leu His Leu Ile Leu Pro Leu Ala Ile Ser Phe Phe Thr Leu Gln Gln
135 140 145ATC GCT TAC TTG ATG GAC ACT TAT AAG CAA AAT CAA ATC ATG CAG CCC 536Ile Ala Tyr Leu Met Asp Thr Tyr Lys Gln Asn Gln Ile Met Gln Pro
150 155 160AAA ATG AGA GAG AGA GTG AGT GAA AAC GCT CCT ATT TTA TTA AAT CCT 584Lys Met Arg Glu Arg Val Ser Glu Asn Ala Pro Ile Leu Leu Asn Pro
165 170 175CCC ACT TCA TTT TTT TCA CTT TCG CAT TTT TTA GAT TAC GCT TTA TTT 632Pro Thr Ser Phe Phe Ser Leu Ser His Phe Leu Asp Tyr Ala Leu Phe
180 185 190GTG AGT TTC TTC CCT CAA CTC ATT GCA GGG CCT ATT GTG CAT CAT AGC 680Val Ser Phe Phe Pro Gln Leu Ile Ala Gly Pro Ile Val His His Ser195 200 205 210GAG ATG ATG CCT CAA TTT AAA GAT AAA AAC AAT CAA TAT TTG AAT TAC 728Glu Met Met Pro Gln Phe Lys Asp Lys Asn Asn Gln Tyr Leu Asn Tyr
215 220 225AGA AAT ATC GCT TTA GGC TTG TTT ATC TTT TCT ATC GGT TTG TTT AAA 776Arg Asn Ile Ala Leu Gly Leu Phe Ile Phe Ser Ile Gly Leu Phe Lys
230 235 240AAG GTC GTG ATT GCA GAT AAT ACC GCT CAT TTT GCT GAT TTT GGA TTT 824Lys Val Val Ile Ala Asp Asn Thr Ala His Phe Ala Asp Phe Gly Phe
245 250 255GAT AAG GCG ACT AGC TTA AGT TTT ATT CAA GCA TGG ATG ACT TCT TTA 872Asp Lys Ala Thr Ser Leu Ser Phe Ile Gln Ala Trp Met Thr Ser Leu
260 265 270TCT TAT TCG TTC CAG CTG TAT TTT GAT TTT AGC GGT TAT TGC GAT ATG 920Ser Tyr Ser Phe Gln Leu Tyr Phe Asp Phe Ser Gly Tyr Cys Asp Met275 280 285 290GCT ATA GGC ATT GGC CTC TTT TTT AAC ATC AAA CTC CCT ATC AAT TTT 968Ala Ile Gly Ile Gly Leu Phe Phe Asn Ile Lys Leu Pro Ile Asn Phe
295 300 305AAT AGC CCC TAT AAG GCT TTG AAT ATC CAA GAT TTT TGG AGG AGG TGG 1016Asn Ser Pro Tyr Lys Ala Leu Asn Ile Gln Asp Phe Trp Arg Arg Trp
310 315 320CAT ATC ACT TTG AGC CGC TTC TTA AAA GAG TAT TTG TAT ATC CCT TTA 1064His Ile Thr Leu Ser Arg Phe Leu Lys Glu Tyr Leu Tyr Ile Pro Leu
325 330 335GGG GGT AAT AGG GTG AAA GAA TTA ATC GTG TAT AGG AAT TTA ATT TTA 1112Gly Gly Asn Arg Val Lys Glu Leu Ile Val Tyr Arg Asn Leu Ile Leu
340 345 350GTG TTT TTG ATT GGG GGG TTT TGG CAT GGG GCT GGT TGG ACT TTT ATC 1160Val Phe Leu Ile Gly Gly Phe Trp His Gly Ala Gly Trp Thr Phe Ile355 360 365 370ATT TGG GGG CTA TTG CAT GGG ATT GCT TTG AGC GTT CAT AGA GCG TAT 1208Ile Trp Gly Leu Leu His Gly Ile Ala Leu Ser Val His Arg Ala Tyr
375 380 385TCT CAT GCC ACT AGA AAA TTC CAT TTC ACT ATG CCA AAG ATT TTA GCA 1256Ser His Ala Thr Arg Lys Phe His Phe Thr Met Pro Lys Ile Leu Ala
390 395 400TGG CTC ATC ACT TTT AAT TTT ATC AAT CTC GCA TGG GTG TTT TTT AGA 1304Trp Leu Ile Thr Phe Asn Phe Ile Asn Leu Ala Trp Val Phe Phe Arg
405 410 415GCC AAA AAT TTA GAA AGC GCT TTG AAG GTT TTA AAG GGG ATG GTT GGT 1352Ala Lys Asn Leu Glu Ser Ala Leu Lys Val Leu Lys Gly Met Val Gly
420 425 430TTG AAT GGT GTT TCG CTT TGT CAT CTT TCA AAA GAG GCA TCA GAG TTT 1400Leu Asn Gly Val Ser Leu Cys His Leu Ser Lys Glu Ala Ser Glu Phe435 440 445 450TTA AAT CGT GTC AAT GAT AAC ATG ATC ATG CAC ACC ATA ATG TAT GCA 1448Leu Asn Arg Val Asn Asp Asn Met Ile Met His Thr Ile Met Tyr Ala
455 460 465TCC CCC ACA TTT AAA ATG TCT GTT TTG ATG ATA ATC ATC TCT TTT TGT 1496Ser Pro Thr Phe Lys Met Cys Val Leu Met Ile Ile Ile Ser Phe Cys
470 475 480TTA AAA AAT AGT TCC CAT TTA TAC CAA TCC AAT CAA ATG GAT TGG ATT 1544Leu Lys Asn Ser Ser His Leu Tyr Gln Ser Asn Gln Met Asp Trp Ile
485 490 495AAA ACA ACA AGC GCT TGT TTG TTG CTC TCT ATA GGT TTT TTA TTT ATT 1592Lys Thr Thr Ser Ala Cys Leu Leu Leu Ser Ile Gly Phe Leu Phe Ile
500 505 510TTT GCC AGT TCT CAA TCG GTA TTT TTG TAT TTT AAT TTT TAGGACACTG CT 1643Phe Ala Ser Ser Gln Ser Val Phe Leu Tyr Phe Asn Phe515 520 525ATGGAATTTT ATAAAAAACA AACTTTAATC ATTGTTTCTT T 1684
(2) Sequence 136 data:
(i) sequence characteristics:
(A) length: 527 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 136: met Leu Ala Ser Ile Ile Ser Ile Leu Arg Val Phe Val Leu Leu Phe 151015 Asn Thr Pro Leu Phe Ile Phe Ala Phe Leu Pro Val Gly Phe Leu Gly
20 25 30Tyr Phe Ile Leu Gln Ala Tyr Ala Lys Asn Pro Leu Phe Pro Lys Leu
35 40 45Trp Leu Val Leu Ala Ser Leu Phe Phe Tyr Ala Phe Trp Asn Val Lys
5055 60Tyr Leu Pro Leu Leu Val Gly Ser Ile Val Phe Asn Tyr Phe Val Ala65 70 75 80Leu Lys Ile His Gln Thr Gln Pro Asn Ala Tyr Lys Arg Leu Trp Leu
85 90 95Ile Leu Gly Leu Ile Ala Asn Val Ser Leu Leu Gly Phe Phe Lys Tyr
100 105 110Thr Asp Phe Phe Leu Thr Asn Phe Asn Leu Ile Trp Lys Ser His Phe
115 120 125Glu Thr Leu His Leu Ile Leu Pro Leu Ala Ile Ser Phe Phe Thr Leu
130 135 140Gln Gln Ile Ala Tyr Leu Met Asp Thr Tyr Lys Gln Asn Gln Ile Met145 150 155 160Gln Pro Lys Met Arg Glu Arg Val Ser Glu Asn Ala Pro Ile Leu Leu
165 170 175Asn Pro Pro Thr Ser Phe Phe Ser Leu Ser His Phe Leu Asp Tyr Ala
180 185 190Leu Phe Val Ser Phe Phe Pro Gln Leu Ile Ala Gly Pro Ile Val His
195 200 205His Ser Glu Met Met Pro Gln Phe Lys Asp Lys Asn Asn Gln Tyr Leu
210 215 220Asn Tyr Arg Asn Ile Ala Leu Gly Leu Phe Ile Phe Ser Ile Gly Leu225 230 235 240Phe Lys Lys Val Val Ile Ala Asp Asn Thr Ala His Phe Ala Asp Phe
245 250 255Gly Phe Asp Lys Ala Thr Ser Leu Ser Phe Ile Gln Ala Trp Met Thr
260 265 270Ser Leu Ser Tyr Ser Phe Gln Leu Tyr Phe Asp Phe Ser Gly Tyr Cys
275280 285Asp Met Ala Ile Gly Ile Gly Leu Phe Phe Asn Ile Lys Leu Pro Ile
290 295 300Asn Phe Asn Ser Pro Tyr Lys Ala Leu Asn Ile Gln Asp Phe Trp Arg305 310 315 320Arg Trp His Ile Thr Leu Ser Arg Phe Leu Lys Glu Tyr Leu Tyr Ile
325 330 335Pro Leu Gly Gly Asn Arg Val Lys Glu Leu Ile Val Tyr Arg Asn Leu
340 345 350Ile Leu Val Phe Leu Ile Gly Gly Phe Trp His Gly Ala Gly Trp Thr
355 360 365Phe Ile Ile Trp Gly Leu Leu His Gly Ile Ala Leu Ser Val His Arg
370 375 380Ala Tyr Ser His Ala Thr Arg Lys Phe His Phe Thr Met Pro Lys Ile385 390 395 400Leu Ala Trp Leu Ile Thr Phe Asn Phe Ile Asn Leu Ala Trp Val Phe
405 410 415Phe Arg Ala Lys Asn Leu Glu Ser Ala Leu Lys Val Leu Lys Gly Met
420 425 430Val Gly Leu Asn Gly Val Ser Leu Cys His Leu Ser Lys Glu Ala Ser
435 440 445Glu Phe Leu Asn Arg Val Asn Asp Asn Met Ile Met His Thr Ile Met
450 455 460Tyr Ala Ser Pro Thr Phe Lys Met Cys Val Leu Met Ile Ile Ile Ser465 470 475 480Phe Cys Leu Lys Asn Ser Ser His Leu Tyr Gln Ser Asn Gln Met Asp
485 490 495Trp Ile Lys Thr Thr Ser Ala Cys Leu Leu Leu Ser Ile Gly Phe Leu
500 505 510Phe IlePhe Ala Ser Ser Gln Ser Val Phe Leu Tyr Phe Asn Phe
515 520 525
(2) Sequence 137 data:
(i) sequence characteristics:
(A) length: 3973bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic RNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...3920
(D) Other information:
(xi) Description of the sequence: sequence 137: AAAGTCGCAC CCTTTGTGCA AAAATCGTTT TACAAGAAGA AAGGAAAAAA ATG GAA 56
Met Glu
1ATA CAA CAA ACA CAC CGC AAA ATC AAT CGC CCT TTG GTT TCT CTC GCT 104Ile Gln Gln Thr His Arg Lys Ile Asn Arg Pro Leu Val Ser Leu Ala
5 10 15TTA GTA GGA GCG TTA GTC AGC ATC ACA CCG CAA CAA AGT CAT GCC GCC 152Leu Val Gly Ala Leu Val Ser Ile Thr Pro Gln Gln Ser His Ala Ala
20 25 30TTT TTC ACA ACC GTG ATC ATT CCA GCC ATT GTT GGG GGG ATT GCT ACA 200Phe Phe Thr Thr Val Ile Ile Pro Ala Ile Val Gly Gly Ile Ala Thr35 40 45 50GGC GCT GCT GTA GGA ACG GTC TCA GGG CTT CTT GGC TGG GGG CTA AAA 248Gly Ala Ala Val Gly Thr Val Ser Gly Leu Leu Gly Trp Gly Leu Lys
55 60 65CAA GCCGAA GAA GCC AAT AAA ACC CCA GAT AAA CCC GAT AAA GTT TGG 296Gln Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys Val Trp
70 75 80CGC ATT CAA GCA GGA AAA GGC TTT AAT GAA TTC CCT AAC AAG GAA TAC 344Arg Ile Gln Ala Gly Lys Gly Phe Asn Glu Phe Pro Asn Lys Glu Tyr
85 90 95GAC TTA TAC AGA TCC CTA CTA TCT AGT AAG ATT GAT GGA GGC TGG GAT 392Asp Leu Tyr Arg Ser Leu Leu Ser Ser Lys Ile Asp Gly Gly Trp Asp
100 105 110TGG GGG AAT GCC GCT ACG CAT TAT TGG GTC AAA GGC GGG CAA TGG AAC 440Trp Gly Asn Ala Ala Thr His Tyr Trp Val Lys Gly Gly Gln Trp Asn115 120 125 130AAG CTT GAA GTG GAT ATG AAA GAC GCT GTA GGG ACT TAT AAT CTC TCA 488Lys Leu Glu Val Asp Met Lys Asp Ala Val Gly Thr Tyr Asn Leu Ser
135 140 145GGG CTA AGA AAC TTT ACT GGT GGG GAT TTA GAT GTC AAT ATG CAA AAA 536Gly Leu Arg Asn Phe Thr Gly Gly Asp Leu Asp Val Asn Met Gln Lys
150 155 160GCC ACT TTG CGC TTG GGC CAA TTC AAT GGC AAT TCT TTC ACA AGC TAT 584Ala Thr Leu Arg Leu Gly Gln Phe Asn Gly Asn Ser Phe Thr Ser Tyr
165 170 175AAG GAT AGC GCT GAT CGC ACC ACG AGA GTG GAT TTC AAC GCT AAA AAT 632Lys Asp Ser Ala Asp Arg Thr Thr Arg Val Asp Phe Asn Ala Lys Asn
180 185 190ATC TTA ATT GAT AAT TTT TTA GAA ATC AAT AAT CGT GTG GGT TCT GGA 680Ile Leu Ile Asp Asn Phe Leu Glu Ile Asn Asn Arg Val Gly Ser Gly195 200 205 210GCC GGG AGG AAA GCC AGC TCT ACG GTT TTA ACT TTG CAA GCT TCA GAA 728Ala Gly Arg Lys Ala Ser Ser Thr Val Leu Thr Leu Gln Ala Ser Glu
215 220 225GGG ATT ACT AGC AGT AAA AAT GCG GAA ATT TCT CTT TAT GAT GGC GCC 776Gly Ile Thr Ser Ser Lys Asn Ala Glu Ile Ser Leu Tyr Asp Gly Ala
230 235 240ACG CTC AAT TTG GCT TCA AAC AGC GTT AAA TTA ATG GGT AAT GTG TGG 824Thr Leu Asn Leu Ala Ser Asn Ser VaI Lys Leu Met Gly Asn Val Trp
245 250 255ATG GGC CGT TTG CAA TAT GTG GGA GCG TAT TTG GCC CCT TCA TAC AGC 872Met Gly Arg Leu Gln Tyr Val Gly Ala Tyr Leu Ala Pro Ser Tyr Ser
260 265 270ACG ATA AAC ACT TCA AAA GTG ACA GGG GAA GTG AAT TTT AAC CAT CTC 920Thr Ile Asn Thr Ser Lys Val Thr Gly Glu Val Asn Phe Asn His Leu275 280 285 290ACT GTG GGC GAT CAC AAC GCC GCT CAA GCA GGC ATT ATC GCT AGT AAC 968Thr Val Gly Asp His Asn Ala Ala Gln Ala Gly Ile Ile Ala Ser Asn
295 300 305AAG ACT CAT ATT GGC ACA CTG GAT TTG TGG CAA AGC GCG GGA CTA AAC 1016Lys Thr His Ile Gly Thr Leu Asp Leu Trp Gln Ser Ala Gly Leu Asn
310 315 320ATT ATC GCC CCT CCA GAA GGC GGT TAT AAG GAT AAA CCT AAG GAT AAA 1064Ile Ile Ala Pro Pro Glu Gly Gly Tyr Lys Asp Lys Pro Lys Asp Lys
325 330 335CCT AGT AAC ACC ACG CAA AAT AAT GCT AAC AAC AAC CAA CAA AAC AGC 1112Pro Ser Asn Thr Thr Gln Asn Asn Ala Asn Asn Asn Gln Gln Asn Ser
340 345 350GCT CAA AAC AAT AGT AAC ACT CAG GTT ATT AAC CCA CCC AAT AGC GCG 1160Ala Gln Asn Asn Ser Asn Thr Gln Val Ile Asn Pro Pro Asn Ser Ala355 360 365370CAA AAA ACA GAA ATT CAA CCC ACG CAA GTC ATT GAT GGG CCT TTT GCT 1208Gln Lys Thr Glu Ile Gln Pro Thr Gln Val Ile Asp Gly Pro Phe Ala
375 380 385GGT GGC AAA GAC ACG GTT GTC AAT ATT GAT CGC ATC AAC ACT AAC GCT 1256Gly Gly Lys Asp Thr Val Val Asn Ile Asp Arg Ile Asn Thr Asn Ala
390 395 400GAT GGC ACG ATT AAA GTG GGA GGG TAT AAA GCT TCT CTT ACC ACC AAT 1304Asp Gly Thr Ile Lys Val Gly Gly Tyr Lys Ala Ser Leu Thr Thr Asn
405 410 415GCG GCT CAT TTG CAT ATC GGC AAA GGC GGT ATC AAT CTG TCC AAT CAA 1352Ala Ala His Leu His Ile Gly Lys Gly Gly Ile Asn Leu Ser Asn Gln
420 425 430GCG AGC GGG CGC ACC CTT TTA GTG GAA AAT CTA ACC GGG AAT ATC ACC 1400Ala Ser Gly Arg Thr Leu Leu Val Glu Asn Leu Thr Gly Asn Ile Thr435 440 445 450GTT GAT GGG CCT TTA AGA GTG AAT AAT CAA GTG GGT GGT TAT GCT TTG 1448Val Asp Gly Pro Leu Arg Val Asn Asn Gln Val Gly Gly Tyr Ala Leu
455 460 465GCA GGA TCA AGC GCG AAT TTT GAG TTT AAG GCT GGT ACG GAT ACC AAA 1496Ala Gly Ser Ser Ala Asn Phe Glu Phe Lys Ala Gly Thr Asp Thr Lys
470 475 480AAC GGC ACA GCC ACT TTT AAT AAC GAT ATT AGT TTG GGA AGA TTT GTG 1544Asn Gly Thr Ala Thr Phe Asn Asn Asp Ile Ser Leu Gly Arg Phe Val
485 490 495AAT TTA AAA GTG GAT GCT CAT ACA GCT AAT TTT AAA GGT ATT GAT ACT 1592Asn Leu Lys Val Asp Ala His Thr Ala Asn Phe Lys Gly Ile Asp Thr
500 505 510GGT AAT GGT GGT TTC AAC ACC TTA GAT TTT AGT GGC GTT ACA GGT AAG1640Gly Asn Gly Gly Phe Asn Thr Leu Asp Phe Ser Gly Val Thr Gly Lys515 520 525 530GTC AAT ATC AAC AAG CTC ATT ACG GCT TCC ACT AAT GTG GCC GTT AAA 1688Val Asn Ile Asn Lys Leu Ile Thr Ala Ser Thr Asn Val Ala Val Lys
535 540 545AAC TTC AAC ATT AAT GAA TTG GTT GTT AAG ACC AAT GGG GTG AGT GTG 1736Asn Phe Asn Ile Asn Glu Leu Val Val Lys Thr Asn Gly Val Ser Val
550 555 560GGG GAA TAC ACT CAT TTT AGC GAA GAT ATA GGC AGT CAA TCG CGC ATC 1784Gly Glu Tyr Thr His Phe Ser Glu Asp Ile Gly Ser Gln Ser Arg Ile
565 570 575AAT ACC GTG CGT TTG GAA ACT GGC ACT AGG TCA ATC TTT TCT GGG GGT 1832Asn Thr Val Arg Leu Glu Thr Gly Thr Arg Ser Ile Phe Ser Gly Gly
580 585 590GTC AAA TTT AAA AGC GGT GAA AAA CTG GTT ATA GAT GAG TTT TAC TAT 1880Val Lys Phe Lys Ser Gly Glu Lys Leu Val Ile Asp Glu Phe Tyr Tyr595 600 605 610AGC CCT TGG AAT TAT TTT GAC GCT AGG AAT ATT AAA AAT GTT GAA ATC 1928Ser Pro Trp Asn Tyr Phe Asp Ala Arg Asn Ile Lys Asn Val Glu Ile
615 620 625ACC AGA AAA TTC GCT TCT TCA ACC CCA GAA AAC CCT TGG GGC ACA TCA 1976Thr Arg Lys Phe Ala Ser Ser Thr Pro Glu Asn Pro Trp Gly Thr Ser
630 635 640AAG CTT ATG TTT AAT AAT CTA ACC CTG GGT CAA AAT GCG GTC ATG GAC 2024Lys Leu Met Phe Asn Asn Leu Thr Leu Gly Gln Asn Ala Val Met Asp
645 650 655TAT AGT CAA TTT TCA AAT TTA ACC ATT CAG GGG GAT TTC ATC AAC AAT 2072Tyr Ser Gln Phe Ser Asn Leu Thr Ile Gln Gly Asp Phe Ile Asn Asn
660 665 670CAA GGC ACT ATC AAT TAT TTG GTC CGA GGC GGG CAA GTA GCC ACC TTG 2120Gln Gly Thr Ile Asn Tyr Leu Val Arg Gly Gly Gln Val Ala Thr Leu675 680 685 690AAT GTA GGC AAT GCG GCA GCT ATG TTC TTT AGT AAT AAT GTG GAT AGC 2168Asn Val Gly Asn Ala Ala Ala Met Phe Phe Ser Asn Asn Val Asp Ser
695 700 705GCG ACT GGG TTT TAC CAA CCG CTC ATG AAG ATT AAC AGC GCT CAA GAT 2216Ala Thr Gly Phe Tyr Gln Pro Leu Met Lys Ile Asn Ser Ala Gln Asp
710 715 720CTC ATT AAA AAT AAA GAA CAT GTC TTA TTG AAA GCG AAA ATC ATC GGT 2264Leu Ile Lys Asn Lys Glu His Val Leu Leu Lys Ala Lys Ile Ile Gly
725 730 735TAT GGC AAT GTT TCT TTA GGC ACT AAC AGC ATT AGT AAT GTT AAT CTA 2312Tyr Gly Asn Val Ser Leu Gly Thr Asn Ser Ile Ser Asn Val Asn Leu
740 745 750ATA GAG CAA TTC AAA GAG CGC CTA GCC CTT TAC AAC AAC AAT AAC CGC 2360Ile Glu Gln Phe Lys Glu Arg Leu Ala Leu Tyr Asn Asn Asn Asn Arg755 760 765 770ATG GAT ATT TGT GTG GTG CGA AAT ACT GAT GAC ATT AAA GCA TGC GGG 2408Met Asp Ile Cys Val Val Arg Asn Thr Asp Asp Ile Lys Ala Cys Gly
775 780 785ACG GCT ATC GGC AAT CAA ACC ATG GTG AAT AAC CCC GAC AAT TAC AAG 2456Thr Ala Ile Gly Asn Gln Ser Met Val Asn Asn Pro Asp Asn Tyr Lys
790 795 800TAT CTT ATC GGT AAA GCA TGG AAG AAC ATA GGG ATC AGC AAA ACA GCT 2504Tyr Leu Ile Gly Lys Ala Trp Lys Asn Ile Gly Ile Ser Lys Thr Ala
805 810 815AAT GGC TCT AAA ATT TCG GTG TAT TAT TTA GGC AAT TCT ACG CCT ACT 2552Asn Gly Ser Lys Ile Ser Val Tyr Tyr Leu Gly Asn Ser Thr Pro Thr
820 825 830GAG AAA GGT GGC AAT ACC ACA AAT TTA CCT ACA AAC ACC ACT AGC AAT 2600Glu Lys Gly Gly Asn Thr Thr Asn Leu Pro Thr Asn Thr Thr Ser Asn835 840 845 850GTG CGT TCT GCC AAC AAC GCC CTT GCG CAA AAC GCT CCT TTC GCT CAA 2648Val Arg Ser Ala Asn Asn Ala Leu Ala Gln Asn Ala Pro Phe Ala Gln
855 860 865CCT AGC GCC ACT CCT AAT TTA GTC GCT ATC AAT CAG CAT GAT TTT GGC 2696Pro Ser Ala Thr Pro Asn Leu Val Ala Ile Asn Gln His Asp Phe Gly
870 875 880ACC ATT GAA AGC GTG TTT GAA TTG GCT AAC CGC TCT AAA GAT ATT GAC 2744Thr Ile Glu Ser Val Phe Glu Leu Ala Asn Arg Ser Lys Asp Ile Asp
885 890 895ACG CTT TAT GCT AAC TCA GGC GCG CAA GGC AGG GAT CTC TTA CAA ACC 2792Thr Leu Tyr Ala Asn Ser Gly Ala Gln Gly Arg Asp Leu Leu Gln Thr
900 905 910TTA TTG ATT GAT AGC CAT GAT GCG GGT TAT GCC AGA CAA ATG ATT GAT 2840Leu Leu Ile Asp Ser His Asp Ala Gly Tyr Ala Arg Gln Met Ile Asp915 920 925 930AAC ACA AGC ACC GGT GAA ATC ACC AAG CAA TTG AAT GCG GCC ACT ACC 2888Asn Thr Ser Thr Gly Glu Ile Thr Lys Gln Leu Asn Ala Ala Thr Thr
935 940 945ACT TTA AAC AAC ATA GCC AGT TTA GAG CAT AAG ACA AGC AGC TTA CAA 2936Thr Leu Asn Asn Ile Ala Ser Leu Glu His Lys Thr Ser Ser Leu Gln
950 955 960ACT TTG AGC TTG AGT AAT GCG ATG ATC TTA AAT TCT CGT TTA GTC AAT 2984Thr Leu Ser Leu Ser Asn Ala Met Ile Leu Asn Ser Arg Leu Val Asn
965 970 975CTC TCC AGA AGG CAC ACC AAT AAT ATT GAC TCA TTC GCC CAA CGC TTA 3032Leu Ser Arg Arg His Thr Asn Asn Ile Asp Ser Phe Ala Gln Arg Leu
980 985 990CAA GCT TTA AAA GAC CAA AAA TTC GCT TCT TTA GAA AGC GCG GCG GAA 3080Gln Ala Leu Lys Asp Gln Lys Phe Ala Ser Leu Glu Ser Ala Ala Glu 995 1000 1005 1010 GTG TTG TAT CAA TTT GCC CCT AAA TAT GAA AAA CCT ACC AAT GTT TGG 3128 Val Leu Tyr Gln Phe Ala Pro Lys Tyr Glu Lys Pro Thr Asn Val Trp
1015 1020 1025 GCT AAC GCT ATT GGG GGA ACG AGC TTG AAT AAT GGC GGC AAC GCT TCA 3176 Ala Asn Ala Ile Gly Gly Thr Ser Leu Asn Asn Gly Gly Asn Ala Ser
1030 1035 1040 TTG TAT GGC ACA AGT GCG GGC GTA GAT GCC TAC CTT AAT GGG GAA GTG 3224 Leu Tyr Gly Thr Ser Ala Gly Val Asp Ala Tyr Leu Asn Gly Glu Val
1045 1050 1055 GAA GCC ATT GTG GGC GGT TTT GGA AGC TAT GGT TAT AGC TCT TTT AAT 3272 Glu Ala Ile Val Gly Gly Phe Gly Ser Tyr Gly Tyr Ser Ser Phe Asn
1060 1065 1070 AAT CAA GCG AAC TCT CTT AAC TCT GGA GCC AAT AAC ACT AAT TTT GGC 3320 Asn Gln Ala Asn Ser Leu Asn Ser Gly Ala Asn Asn Thr Asn Phe Gly1075 1080 1085 1090 GTG TAT AGC CGT ATC TTT GCT AAC CAG CAT GAA TTT GAT TTT GAA GCT 3368 Val Tyr Ser Arg Ile Phe Ala Asn Gln His Glu Phe Asp Phe Glu Ala
1095 1100 1105 CAA GGG GCG CTA GGG AGT GAT CAA TCA AGC TTG AAT TTC AAA AGC GCT 3416 Gln Gly Ala Leu Gly Ser Asp Gln Ser Ser Leu Asn Phe Lys Ser Ala
1110 1115 1120 CTA TTG CGA GAT TTG AAT CAA AGC TAT AAT TAC TTA GCC TAT AGC GCT 3464 Leu Leu Arg Asp Leu Asn Gln Ser Tyr Asn Tyr Leu Ala Tyr Ser Ala
1125 1130 1135 GCA ACA AGA GCG AGC TAT GGT TAT GAC TTT GCA TTT TTT AGG AAC GCT 3512 Ala Thr Arg Ala Ser Tyr Gly Tyr Asp Phe Ala Phe Phe Arg Asn Ala
1140 1145 1150 TTG GTG TTA AAA CCA AGC GTG GGC GTG AGC TAT AAC CAT TTA GGT TCA 3560 Leu Val Leu Lys Pro Ser Val Gly Val Ser Tyr Asn His Leu Gly Ser1155 1160 1165 1170 ACC AAC TTT AAA AGC AAT AGC AAT CAA GTG GCT TTG AAA AAT GGC TCT 3608Thr Asn Phe Lys Ser Asn Ser Asn Gln Val Ala Leu Lys Asn Gly Ser
1175 1180 1185 AGC AGT CAG CAT TTA TTC AAC GCT AGC GCT AAT GTG GAA GCG CGC TAT 3656 Ser Ser Gln His Leu Phe Asn Ala Ser Ala Asn Val Glu Ala Arg Tyr
1190 1195 1200 TAT TAT GGG GAC ACT TCA TAC TTC TAT ATG AAC GCT GGA GTT TTA CAA 3704 Tyr Tyr Gly Asp Thr Ser Tyr Phe Tyr Met Asn Ala Gly Val Leu Gln
1205 1210 1215 GAA TTT GCT AAC TTT GGT TCT AGC AAT GCG GTA TCT TTA AAC ACC TTT 3752 Glu Phe Ala Asn Phe Gly Ser Ser Asn Ala Val Ser Leu Asn Thr Phe
1220 1225 1230 AAA GTG AAT GCC GCA CAC AAT CCT TTA AGT ACC CAT GCC AGA GTG ATG 3800 Lys Val Asn Ala Ala His Asn Pro Leu Ser Thr His Ala Arg Val Met1235 1240 1245 1250 ATG GGT GGG GAA TTA AAA TTA GCT AAA GAA GTG TTT TTG AAT TTG GGC 3848 Met Gly Gly Glu Leu Lys Leu Ala Lys Glu Val Phe Leu Asn Leu Gly
1255 1260 1265 TTT GTT TAT TTG CAC AAT TTG ATT TCC AAT ATA GGC CAT TTC GCT TCC 3896Phe Val Tyr Leu His Asn Leu Ile Ser Asn Ile Gly His Phe Ala Ser
1270 1275 1280 AAT TTA GGA ATG AGG TAT AGT TTC TAAATACCGC TCTTAAACCC ATGCTCAAAG 3950 Asn Leu Gly Met Arg Tyr Ser Phe
1285 1290 CATGGGTTTG AAATCTTACA AAA 3973
(2) Sequence 138 data:
(i) sequence characteristics:
(A) length: 1290 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 138: met Glu Ile Gln Gln Thr His Arg Lys Ile Asn Arg Pro Leu Val Ser 151015 Leu Ala Leu Val Gly Ala Leu Val Ser Ile Thr Pro Gln Gln Ser His
20 25 30Ala Ala Phe Phe Thr Thr Val Ile Ile Pro Ala Ile Val Gly Gly Ile
35 40 45Ala Thr Gly Ala Ala Val Gly Thr Val Ser Gly Leu Leu Gly Trp Gly
50 55 60Leu Lys Gln Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys65 70 75 80Val Trp Arg Ile Gln Ala Gly Lys Gly Phe Asn Glu Phe Pro Asn Lys
85 90 95Glu Tyr Asp Leu Tyr Arg Ser Leu Leu Ser Ser Lys Ile Asp Gly Gly
100 105 110Trp Asp Trp Gly Asn Ala Ala Thr His Tyr Trp Val Lys Gly Gly Gln
115 120 125Trp Asn Lys Leu Glu Val Asp Met Lys Asp Ala Val Gly Thr Tyr Asn
130 135 140Leu Ser Gly Leu Arg Asn Phe Thr Gly Gly Asp Leu Asp Val Asn Met145 150 155 160Gln Lys Ala Thr Leu Arg Leu Gly Gln Phe Asn Gly Asn Ser Phe Thr
165 170 175Ser Tyr Lys Asp Ser Ala Asp Arg Thr Thr Arg Val Asp Phe Asn Ala
180 185 190Lys Asn Ile Leu Ile Asp Asn Phe Leu Glu Ile Asn Asn Arg Val Gly
195 200 205Ser Gly Ala Gly Arg Lys Ala Ser Ser Thr Val Leu Thr Leu Gln Ala
210 215 220Ser Glu Gly Ile Thr Ser Ser Lys Asn Ala Glu Ile Ser Leu Tyr Asp225 230 235 240Gly Ala Thr Leu Asn Leu Ala Ser Asn Ser Val Lys Leu Met Gly Asn
245 250 255Val Trp Met Gly Arg Leu Gln Tyr Val Gly Ala Tyr Leu Ala Pro Ser
260 265 270Tyr Ser Thr Ile Asn Thr Ser Lys Val Thr Gly Glu Val Asn Phe Asn
275 280 285His Leu Thr Val Gly Asp His Asn Ala Ala Gln Ala Gly Ile Ile Ala
290 295 300Ser Asn Lys Thr His Ile Gly Thr Leu Asp Leu Trp Gln Ser Ala Gly305 310 315 320Leu Asn Ile Ile Ala Pro Pro Glu Gly Gly Tyr Lys Asp Lys Pro Lys
325 330 335Asp Lys Pro Ser Asn Thr Thr Gln Asn Asn Ala Asn Asn Asn Gln Gln
340345 350Asn Ser Ala Gln Asn Asn Ser Asn Thr Gln Val Ile Asn Pro Pro Asn
355 360 365Ser Ala Gln Lys Thr Glu Ile Gln Pro Thr Gln Val Ile Asp Gly Pro
370 375 380Phe Ala Gly Gly Lys Asp Thr Val Val Asn Ile Asp Arg Ile Asn Thr385 390 395 400Asn Ala Asp Gly Thr Ile Lys Val Gly Gly Tyr Lys Ala Ser Leu Thr
405 410 415Thr Asn Ala Ala His Leu His Ile Gly Lys Gly Gly Ile Asn Leu Ser
420 425 430Asn Gln Ala Ser Gly Arg Thr Leu Leu Val Glu Asn Leu Thr Gly Asn
435 440 445Ile Thr Val Asp Gly Pro Leu Arg Val Asn Asn Gln Val Gly Gly Tyr
450 455 460Ala Leu Ala Gly Ser Ser Ala Asn Phe Glu Phe Lys Ala Gly Thr Asp465 470 475 480Thr Lys Asn Gly Thr Ala Thr Phe Asn Asn Asp Ile Ser Leu Gly Arg
485 490 495Phe Val Asn Leu Lys Val Asp Ala His Thr Ala Asn Phe Lys Gly Ile
500 505 510Asp Thr Gly Asn Gly Gly Phe Asn Thr Leu Asp Phe Ser Gly Val Thr
515 520 525Gly Lys Val Asn Ile Asn Lys Leu Ile Thr Ala Ser Thr Asn Val Ala
530 535 540Val Lys Asn Phe Asn Ile Asn Glu Leu Val Val Lys Thr Asn Gly Val545 550 555 560Ser Val Gly Glu Tyr Thr His Phe Ser Glu Asp Ile Gly Ser Gln Ser
565 570 575Arg Ile Asn ThrVal Arg Leu Glu Thr Gly Thr Arg Ser Ile Phe Ser
580 585 590Gly Gly Val Lys Phe Lys Ser Gly Glu Lys Leu Val Ile Asp Glu Phe
595 600 605Tyr Tyr Ser Pro Trp Asn Tyr Phe Asp Ala Arg Asn Ile Lys Asn Val
610 615 620Glu Ile Thr Arg Lys Phe Ala Ser Ser Thr Pro Glu Asn Pro Trp Gly625 630 635 640Thr Ser Lys Leu Met Phe Asn Asn Leu Thr Leu Gly Gln Asn Ala Val
645 650 655Met Asp Tyr Ser Gln Phe Ser Asn Leu Thr Ile Gln Gly Asp Phe Ile
660 665 670Asn Asn Gln Gly Thr Ile Asn Tyr Leu Val Arg Gly Gly Gln Val Ala
675 680 685Thr Leu Asn Val Gly Asn Ala Ala Ala Met Phe Phe Ser Asn Asn Val
690 695 700Asp Ser Ala Thr Gly Phe Tyr Gln Pro Leu Met Lys Ile Asn Ser Ala705 710 715 720Gln Asp Leu Ile Lys Asn Lys Glu His Val Leu Leu Lys Ala Lys Ile
725 730 735Ile Gly Tyr Gly Asn Val Ser Leu Gly Thr Asn Ser Ile Ser Asn Val
740 745 750Asn Leu Ile Glu Gln Phe Lys Glu Arg Leu Ala Leu Tyr Asn Asn Asn
755 760 765Asn Arg Met Asp Ile Cys Val Val Arg Asn Thr Asp Asp Ile Lys Ala
770 775 780Cys Gly Thr Ala Ile Gly Asn Gln Ser Met Val Asn Asn Pro Asp Asn785 790 795 800Tyr Lys Tyr Leu Ile Gly Lys Ala Trp LysAsn Ile Gly Ile Ser Lys
805 810 815Thr Ala Asn Gly Ser Lys Ile Ser Val Tyr Tyr Leu Gly Asn Ser Thr
820 825 830Pro Thr Glu Lys Gly Gly Asn Thr Thr Asn Leu Pro Thr Asn Thr Thr
835 840 845Ser Asn Val Arg Ser Ala Asn Asn Ala Leu Ala Gln Asn Ala Pro Phe
850 855 860Ala Gln Pro Ser Ala Thr Pro Asn Leu Val Ala Ile Asn Gln His Asp865 870 875 880Phe Gly Thr Ile Glu Ser Val Phe Glu Leu Ala Asn Arg Ser Lys Asp
885 890 895Ile Asp Thr Leu Tyr Ala Asn Ser Gly Ala Gln Gly Arg Asp Leu Leu
900 905 910Gln Thr Leu Leu Ile Asp Ser His Asp Ala Gly Tyr Ala Arg Gln Met
915 920 925Ile Asp Asn Thr Ser Thr Gly Glu Ile Thr Lys Gln Leu Asn Ala Ala
930 935 940Thr Thr Thr Leu Asn Asn Ile Ala Ser Leu Glu His Lys Thr Ser Ser945 950 955 960Leu Gln Thr Leu Ser Leu Ser Asn Ala Met Ile Leu Asn Ser Arg Leu
965 970 975Val Asn Leu Ser Arg Arg His Thr Asn Asn Ile Asp Ser Phe Ala Gln
980 985 990Arg Leu Gln Ala Leu Lys Asp Gln Lys Phe Ala Ser Leu Glu Ser Ala
995 1000 1005Ala Glu Val Leu Tyr Gln Phe Ala Pro Lys Tyr Glu Lys Pro Thr Asn 1010 1015 1020Val Trp Ala Asn Ala Ile Gly Gly Thr Ser Leu Asn Asn Gly Gly Asn025 10301035 1040Ala Ser Leu Tyr Gly Thr Ser Ala Gly Val Asp Ala Tyr Leu Asn Gly
1045 1050 1055Glu Val Glu Ala Ile Val Gly Gly Phe Gly Ser Tyr Gly Tyr Ser Ser
1060 1065 1070Phe Asn Asn Gln Ala Asn Ser Leu Asn Ser Gly Ala Asn Asn Thr Asn
1075 1080 1085Phe Gly Val Tyr Ser Arg Ile Phe Ala Asn Gln His Glu Phe Asp Phe 1090 1095 1100Glu Ala Gln Gly Ala Leu Gly Ser Asp Gln Ser Ser Leu Asn Phe Lys105 1110 1115 1120Ser Ala Leu Leu Arg Asp Leu Asn Gln Ser Tyr Asn Tyr Leu Ala Tyr
1125 1130 1135Ser Ala Ala Thr Arg Ala Ser Tyr Gly Tyr Asp Phe Ala Phe Phe Arg
1140 1145 1150Asn Ala Leu Val Leu Lys Pro Ser Val Gly Val Ser Tyr Asn His Leu
1155 1160 1165Gly Ser Thr Asn Phe Lys Ser Asn Ser Asn Gln Val Ala Leu Lys Asn 1170 1175 1180Gly Ser Ser Ser Gln His Leu Phe Asn Ala Ser Ala Asn Val Glu Ala185 1190 1195 1200Arg Tyr Tyr Tyr Gly Asp Thr Ser Tyr Phe Tyr Met Asn Ala Gly Val
1205 1210 1215Leu Gln Glu Phe Ala Asn Phe Gly Ser Ser Asn Ala Val Ser Leu Asn
1220 1225 1230Thr Phe Lys Val Asn Ala Ala His Asn Pro Leu Ser Thr His Ala Arg
1235 1240 1245Val Met Met Gly Gly Glu Leu Lys Leu Ala Lys Glu Val Phe Leu Asn 1250 1255 1260Leu Gly Phe Val Tyr Leu His Asn Leu Ile Ser Asn Ile GlyHis Phe265 1270 1275 1280Ala Ser Asn Leu Gly Met Arg Tyr Ser Phe
1285 1290
(2) Sequence 139 data:
(i) sequence characteristics:
(A) length: 1335bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 55...1284
(D) Other information:
(xi) Description of the sequence: sequence 139: TTAGTAGAAA TTGAAGCGAT AGCCATTAAG TAATTTATTA AAGGGACTAT CAGC ATG 57
Met
1AAA AAA GAG GTC GTG GTC ATA GGC GGT GGG ATT GTA GGG CTT TCT TGT 105Lys Lys Glu Val Val Val Ile Gly Gly Gly Ile Val Gly Leu Ser Cys
5 10 15GCG TAT TCT ATG CAC AAG TTA GGG CAT AAG GTC TGC GTG ATA GAA AAA 153Ala Tyr Ser Met His Lys Leu Gly His Lys Val Cys Val Ile Glu Lys
20 25 30AAC GAT GGC GCA AAC GGC ACT TCT TTT GGG AAT GCT GGG CTT ATT TCT 201Asn Asp Gly Ala Asn Gly Thr Ser Phe Gly Asn Ala Gly Leu Ile Ser
35 40 45GCG TTT AAA AAA GCC CCA CTC TCA TGC CCT GGT GTG GTG TTA GAC ACC 249Ala Phe Lys Lys Ala Pro Leu Ser Cys Pro Gly Val Val Leu Asp Thr50 5560 65CTG AAG CTC ATG CTC AAA AAC CAA GCC CCT TTA AAA TTC CAT TTC GGG 297Leu Lys Leu Met Leu Lys Asn Gln Ala Pro Leu Lys Phe His Phe Gly
70 75 80CTT AAT TTA AAG CTC TAT CAA TGG ATT TTA AAA TTT GTA AAA AGC GCG 345Leu Asn Leu Lys Leu Tyr Gln Trp Ile Leu Lys Phe Val Lys Ser Ala
85 90 95AAC GCC AAA TCC ACG CAC CGC ACC ATG GCG TTG TTT GAA CGC TAC GGG 393Asn Ala Lys Ser Thr His Arg Thr Met Ala Leu Phe Glu Arg Tyr GIy
100 105 110TGG CTG AGT ATT GAT ATG TAT CAT CAA ATG CTA AAA GAC GGC ATG GAC 441Trp Leu Ser Ile Asp Met Tyr His Gln Met Leu Lys Asp Gly Met Asp
115 120 125TTT TGG TAT AAA GAA GAT GGG CTT TTA ATG ATC TAC ACT CTA GAA GAA 489Phe Trp Tyr Lys Glu Asp Gly Leu Leu Met Ile Tyr Thr Leu Glu Glu130 135 140 145AGT TTT GAA AAA AAG CTT AAA ACT TGC GAT AAC AGC GGC GCT TAT AAA 537Ser Phe Glu Lys Lys Leu Lys Thr Cys Asp Asn Ser Gly Ala Tyr Lys
150 155 160ATC CTT AGC GCT AAA GAG ACC AAA GAA TAC ATG CCC GTT GTT AAT GAC 585Ile Leu Ser Ala Lys Glu Thr Lys Glu Tyr Met Pro Val Val Asn Asp
165 170 175AAT ATC TGC GGG AGC GTG CTT TTA ACC GAA AAC GCG CAT GTG GAT CCG 633Asn Ile Cys Gly Ser Val Leu Leu Thr Glu Asn Ala His Val Asp Pro
180 185 190GGC GAA GTG ATG CAC TCT TTG CAA GAA TAT TTA CAA AAT GTT GGC GTG 681Gly Glu Val Met His Ser Leu Gln Glu Tyr Leu Gln Asn Val Gly Val
195 200 205GAG TTC CTT TAT AAT GAA GAA GTG ATC GAT TTT GAG TTTAAA AAT AAC 729Glu Phe Leu Tyr Asn Glu Glu Val Ile Asp Phe Glu Phe Lys Asn Asn210 215 220 225CTC ATT GAG GGC GTT ATC ACG CAC AAG GAA AAA ATC CAA GCA GAA ACA 777Leu Ile Glu Gly Val Ile Thr His Lys Glu Lys Ile Gln Ala Glu Thr
230 235 240ATC ATT CTA GCC ACT GGG GCT AAC CCC ACT CTC ATT AAA AAA ACC AAG 825Ile Ile Leu Ala Thr Gly Ala Asn Pro Thr Leu Ile Lys Lys Thr Lys
245 250 255AAC GAT TTT TTA ATG ATG GGG GCT AAA GGA TAT AGC ATC ACC TTT AAA 873Asn Asp Phe Leu Met Met Gly Ala Lys Gly Tyr Ser Ile Thr Phe Lys
260 265 270ATG CCT GAA GAA TTA AAA CCC AAA ACC TCT TCT TTA TTT GCG GAT ATT 921Met Pro Glu Glu Leu Lys Pro Lys Thr Ser Ser Leu Phe Ala Asp Ile
275 280 285TTC ATG GCG ATG ACC CCA CGA AGA GAC ACT GTA AGG ATC ACT TCT AAA 969Phe Met Ala Met Thr Pro Arg Arg Asp Thr Val Arg Ile Thr Ser Lys290 295 300 305TTA GAA TTA AAC ACC AAC AAC GCT CTC ATT GAT AAA GAG CAA ATC GCT 1017Leu Glu Leu Asn Thr Asn Asn Ala Leu Ile Asp Lys Glu Gln Ile Ala
310 315 320AAC ATG AAA AAG AAT TTA GCC GCT TTC ACG CAG CCT TTT GAA ATG AAA 1065Asn Met Lys Lys Asn Leu Ala Ala Phe Thr Gln Pro Phe Glu Met Lys
325 330 335GAC GCC ATA GAG TGG TGC GGT TTC AGA CCC TTA ACC CCT AAT GAT ATT 1113Asp Ala Ile Glu Trp Cys Gly Phe Arg Pro Leu Thr Pro Asn Asp Ile
340 345 350CCT TAT TTG GGC TAT GAC AAA CGC TAT AAA AAC TTA ATC CAT GCG ACA 1161Pro Tyr Leu Gly Tyr Asp Lys Arg Tyr Lys Asn Leu Ile His Ala Thr
355 360 365GGG CTA GGG TGG CTT GGC ATC ACT TTT GGC CCA GCC ATT GGT AAA ATC 1209Gly Leu Gly Trp Leu Gly Ile Thr Phe Gly Pro Ala Ile Gly Lys Ile370 375 380 385ATC GCC AAT TTG AGC CAA GAC GGA GCG AAT GAA AAA AAT GCC GAT ATT 1257Ile Ala Asn Leu Ser Gln Asp Gly Ala Asn Glu Lys Asn Ala Asp Ile
390 395 400ATG CTT TTT TCT GCA TTT TTT AGG GAT TAAGGAATTT CTTTTTTAAA CCCTAGT 1311Met Leu Phe Ser Ala Phe Phe Arg Asp
405 410TTATTAAGGA GTTTTTATGG AAAC 1335
(2) Sequence 140 data:
(i) sequence characteristics:
(A) length: 410 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 140: met Lys Lys Glu Val Val Val Ile Gly Gly Gly Ile Val Gly Leu Ser 151015 Cys Ala Tyr Ser Met His Lys Leu Gly His Lys Val Cys Val Ile Glu
20 25 30Lys Asn Asp Gly Ala Asn Gly Thr Ser Phe Gly Asn Ala Gly Leu Ile
35 40 45Ser Ala Phe Lys Lys Ala Pro Leu Ser Cys Pro Gly Val Val Leu Asp
50 55 60Thr Leu Lys Leu Met Leu Lys Asn Gln Ala Pro Leu Lys Phe His Phe65 70 75 80Gly Leu Asn Leu Lys Leu Tyr Gln Trp Ile Leu Lys Phe Val Lys Ser
85 90 95Ala Asn Ala Lys Ser Thr His Arg Thr Met Ala Leu Phe Glu Arg Tyr
100 105 110Gly Trp Leu Ser Ile Asp Met Tyr His Gln Met Leu Lys Asp Gly Met
115 120 125Asp Phe Trp Tyr Lys Glu Asp Gly Leu Leu Met Ile Tyr Thr Leu Glu
130 135 140Glu Ser Phe Glu Lys Lys Leu Lys Thr Cys Asp Asn Ser Gly Ala Tyr145 150 155 160Lys Ile Leu Ser Ala Lys Glu Thr Lys Glu Tyr Met Pro Val Val Asn
165 170 175Asp Asn Ile Cys Gly Ser Val Leu Leu Thr Glu Asn Ala His Val Asp
180 185 190Pro Gly Glu Val Met His Ser Leu Gln Glu Tyr Leu Gln Asn Val Gly
195 200 205Val Glu Phe Leu Tyr Asn Glu Glu Val Ile Asp Phe Glu Phe Lys Asn
210 215 220Asn Leu Ile Glu Gly Val Ile Thr His Lys Glu Lys Ile Gln Ala Glu225 230 235 240Thr Ile Ile Leu Ala Thr Gly Ala Asn Pro Thr Leu Ile Lys Lys Thr
245 250 255Lys Asn Asp Phe Leu Met Met Gly Ala Lys Gly Tyr Ser Ile Thr Phe
260 265 270Lys Met Pro Glu Glu Leu Lys Pro Lys Thr Ser Ser Leu Phe Ala Asp
275 280 285Ile Phe Met Ala Met Thr Pro Arg Arg Asp Thr Val Arg Ile Thr Ser
290 295 300Lys Leu Glu Leu Asn Thr Asn Asn Ala Leu Ile Asp Lys Glu Gln Ile305 310315 320Ala Asn Met Lys Lys Asn Leu Ala Ala Phe Thr Gln Pro Phe Glu Met
325 330 335Lys Asp Ala Ile Glu Trp Cys Gly Phe Arg Pro Leu Thr Pro Asn Asp
340 345 350Ile Pro Tyr Leu Gly Tyr Asp Lys Arg Tyr Lys Asn Leu Ile His Ala
355 360 365Thr Gly Leu Gly Trp Leu Gly Ile Thr Phe Gly Pro Ala Ile Gly Lys
370 375 380Ile Ile Ala Asn Leu Ser Gln Asp Gly Ala Asn Glu Lys Asn Ala Asp385 390 395 400Ile Met Leu Phe Ser Ala Phe Phe Arg Asp
405 410
(2) Sequence 141 data:
(i) sequence characteristics:
(A) length: 1579bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1526
(D) Other information:
(xi) Description of the sequence: sequence 141: AAAAACGCTA TAAGATAGTC AAATACATTC AATAAATGCA AGGGGAAATC ATG GAA 56
Met Glu
1CAT AAA GAA ATC GTT ATA GGG GTT GAT CTA GGC TCT AGA AAG ATT TGC 104His Lys Glu Ile Val Ile Gly Val Asp Leu Gly Ser Arg Lys Ile Cys
5 10 15GCG ATA GTG GCT GAA TTT AAA GAA GGG ATT TTG CGC ATC ATT GGC ACG 152Ala Ile Val Ala Glu Phe Lys Glu Gly Ile Leu Arg Ile Ile Gly Thr
20 25 30GCC CAT CAA GAC TCC AAA GAA ATC AAT TCA AAA GCC ATT AAA AGA GGG 200Ala His Gln Asp Ser Lys Glu Ile Asn Ser Lys Ala Ile Lys Arg Gly35 40 45 50CGT ATC AAT AGC CTT GCT CAC GCT TCC AAC GCC ATT AAA GAA GTG ATT 248Arg Ile Asn Ser Leu Ala His Ala Ser Asn Ala Ile Lys Glu Val Ile
55 60 65AAT AGC GCT AAA AAA ATG GCA GGT TTG AAC GCT GAT GAA GAC AGA AAT 296Asn Ser Ala Lys Lys Met Ala Gly Leu Asn Ala Asp Glu Asp Arg Asn
70 75 80AAC CCC ATG CCC CAT TTT GGG GAA TAC CAC CCT AAA ACT AAG GCG ATT 344Asn Pro Met Pro His Phe Gly Glu Tyr His Pro Lys Thr Lys Ala Ile
85 90 95GTT TCT TTT TCT GGG GCT TAT ACT GAA AGC ATT AGA GAT GTT ACC GGT 392Val Ser Phe Ser Gly Ala Tyr Thr Glu Ser Ile Arg Asp Val Thr Gly
100 105 110GTA GCG AGC ACC AAA GAT AAT GTG GTA ACC ATT GAT GAA ATC AAT CGC 440Val Ala Ser Thr Lys Asp Asn Val Val Thr Ile Asp Glu Ile Asn Arg115 120 125 130GCT ATC AAT AGT GCA TGC GCT AAA GCA GGC TTA GAT AAC GAC AAA CAT 488Ala Ile Asn Ser Ala Cys Ala Lys Ala Gly Leu Asp Asn Asp Lys His
135 140 145ATT TTG CAT GCT CTC CCC TAT CGC TTC ACT TTA GAC AAA CAA GAA GTG 536Ile Leu His Ala Leu Pro Tyr Arg Phe Thr Leu Asp Lys Gln Glu Val
150 155 160AAT GAC CCT TTA GGG ATGAGC GGG ACT CGC TTG GAA GTC TTT ATC CAC 584Asn Asp Pro Leu Gly Met Ser Gly Thr Arg Leu Glu Val Phe Ile His
165 170 175ATT GTC TAT ACA GAA AAA AAC AAC ATT GAA AAT TTA GAA AAA ATC ATG 632Ile Val Tyr Thr Glu Lys Asn Asn Ile Glu Asn Leu Glu Lys Ile Met
180 185 190ATC CAA TCT GGG GTA GAG ATT GAA AAC ATC GTG ATC AAT TCT TAT GCA 680Ile Gln Ser Gly Val Glu Ile Glu Asn Ile Val Ile Asn Ser Tyr Ala195 200 205 210GCC TCG ATT GCC ACC TTA TCT AAT GAT GAA AGG GAA TTG GGC GTG GCT 728Ala Ser Ile Ala Thr Leu Ser Asn Asp Glu Arg Glu Leu Gly Val Ala
215 220 225TGC GTG GAT ATG GGC GGA GAG ACA TGC AAC CTT ACG ATT TAT AGC GGC 776Cys Val Asp Met Gly Gly Glu Thr Cys Asn Leu Thr Ile Tyr Ser Gly
230 235 240AAT TCC ATA CGC TAT AAC AAA TAT TTG CCC GTA GGC TCT CAC CAT TTA 824Asn Ser Ile Arg Tyr Asn Lys Tyr Leu Pro Val Gly Ser His His Leu
245 250 255ACC ACG GAT TTA TCG CAC ATG CTC AAC ACC CCA TTC CCT TAC GCT GAA 872Thr Thr Asp Leu Ser His Met Leu Asn Thr Pro Phe Pro Tyr Ala Glu
260 265 270GAA GTT AAG ATC AAA TAC GGG GAT CTT TCT TTT GAA GGC GGC GAA GAA 920Glu Val Lys Ile Lys Tyr Gly Asp Leu Ser Phe Glu Gly Gly Glu Glu275 280 285 290ACG CCC TCT CAA AAT GTC CAA ATC CCT ACC ACC GGC TCG GAT GGC CAT 968Thr Pro Ser Gln Asn Val Gln Ile Pro Thr Thr Gly Ser Asp Gly His
295 300 305GAA AGC CAT ATT GTG CCG CTT AGT GAA ATC CAA ACT ATC ATG AGA GAA 1016Glu Ser His Ile Val Pro Leu Ser Glu Ile Gln Thr Ile MetArg Glu
310 315 320AGG GCT TTA GAA ACT TTT AAA ATC ATC CAC AGG AGC ATT CAA GAT AGC 1064Arg Ala Leu Glu Thr Phe Lys Ile Ile His Arg Ser Ile Gln Asp Ser
325 330 335GGC TTA GAA GAG CAT TTG GGC GGA GGC GTT GTG TTA ACC GGT GGG ATG 1112Gly Leu Glu Glu His Leu Gly Gly Gly Val Val Leu Thr Gly Gly Met
340 345 350GCT TTA ATG AAA GGG ATC AAA GAA TTA GCC AGA ACC CAT TTC ACT AAT 1160Ala Leu Met Lys Gly Ile Lys Glu Leu Ala Arg Thr His Phe Thr Asn355 360 365 370TAC CCG GTG CGT TTG GCA GCC CCT GTG GAA AAA TAC AAT ATC ATG GGC 1208Tyr Pro Val Arg Leu Ala Ala Pro Val Glu Lys Tyr Asn Ile Met Gly
375 380 385ATG TTT GAA GAT TTG AAA GAC CCT CGC TTT TCA GTC GTA GTT GGC TTG 1256Met Phe Glu Asp Leu Lys Asp Pro Arg Phe Ser Val Val Val Gly Leu
390 395 400ATT TTA TAC AAA GCA GGG GGG CAT ACC AAT TAT GAA AGA GAC TCT AAA 1304Ile Leu Tyr Lys Ala Gly Gly His Thr Asn Tyr Glu Arg Asp Ser Lys
405 410 415GGG GTT ATC CGC TAC CAT GAA AGC GAT GAT TAC ACA AGA ACA GCC CAT 1352Gly Val Ile Arg Tyr His Glu Ser Asp Asp Tyr Thr Arg Thr Ala His
420 425 430CAA TCA AGC CCT ACC CCC CAT ATC CAT TCA TCG CCC ACA GAA AGG AAT 1400Gln Ser Ser Pro Thr Pro His Ile His Ser Ser Pro Thr Glu Arg Asn435 440 445 450TTG AGC GAT TTA AAA GCC CCT AGT GCT CCT TTA AAC ACC GCT AAA AAC 1448Leu Ser Asp Leu Lys Ala Pro Ser Ala Pro Leu Asn Thr Ala Lys Asn
455 460 465GATGAC TTT TTA CCT ATA AAA CCC ACC GAA CAA AAA GGT TTT TTT AAA 1496Asp Asp Phe Leu Pro Ile Lys Pro Thr Glu Gln Lys Gly Phe Phe Lys
470 475 480AGT TTC CTT GAT AAG ATT TCT AAA TTC TTT TAAGATACAG CCATTTCTTT ATG 1549Ser Phe Leu Asp Lys Ile Ser Lys Phe Phe
485 490CGATAAAAAC GCCTTGATGG TTATCAAAAG 1579
(2) Sequence 142 data:
(i) sequence characteristics:
(A) length: 492 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 142: met Glu His Lys Glu Ile Val Ile Gly Val Asp Leu Gly Ser Arg Lys 151015 Ile Cys Ala Ile Val Ala Glu Phe Lys Glu Gly Ile Leu Arg Ile Ile
20 25 30Gly Thr Ala His Gln Asp Ser Lys Glu Ile Asn Ser Lys Ala Ile Lys
35 40 45Arg Gly Arg Ile Asn Ser Leu Ala His Ala Ser Asn Ala Ile Lys Glu
50 55 60Val Ile Asn Ser Ala Lys Lys Met Ala Gly Leu Asn Ala Asp Glu Asp65 70 75 80Arg Asn Asn Pro Met Pro His Phe Gly Glu Tyr His Pro Lys Thr Lys
85 90 95Ala Ile Val Ser Phe Ser Gly Ala Tyr Thr Glu Ser Ile Arg Asp Val
100 105 110Thr Gly Val Ala Ser Thr Lys Asp Asn Val Val Thr Ile Asp Glu Ile
115 120 125Asn Arg Ala Ile Asn Ser Ala Cys Ala Lys Ala Gly Leu Asp Asn Asp
130 135 140Lys His Ile Leu His Ala Leu Pro Tyr Arg Phe Thr Leu Asp Lys Gln145 150 155 160Glu Val Asn Asp Pro Leu Gly Met Ser Gly Thr Arg Leu Glu Val Phe
165 170 175Ile His Ile Val Tyr Thr Glu Lys Asn Asn Ile Glu Asn Leu Glu Lys
180 185 190Ile Met Ile Gln Ser Gly Val Glu Ile Glu Asn Ile Val Ile Asn Ser
195 200 205Tyr Ala Ala Ser Ile Ala Thr Leu Ser Asn Asp Glu Arg Glu Leu Gly
210 215 220Val Ala Cys Val Asp Met Gly Gly Glu Thr Cys Asn Leu Thr Ile Tyr225 230 235 240Ser Gly Asn Ser Ile Arg Tyr Asn Lys Tyr Leu Pro Val Gly Ser His
245 250 255His Leu Thr Thr Asp Leu Ser His Met Leu Asn Thr Pro Phe Pro Tyr
260 265 270Ala Glu Glu Val Lys Ile Lys Tyr Gly Asp Leu Ser Phe Glu Gly Gly
275 280 285Glu Glu Thr Pro Ser Gln Asn Val Gln Ile Pro Thr Thr Gly Ser Asp
290 295 300Gly His Glu Ser His Ile Val Pro Leu Ser Glu Ile Gln Thr Ile Met305 310 315 320Arg Glu Arg Ala Leu Glu Thr Phe Lys Ile Ile His Arg Ser Ile Gln
325 330 335Asp Ser Gly Leu Glu Glu His Leu Gly Gly Gly Val Val Leu Thr Gly
340 345 350Gly Met Ala Leu Met Lys Gly Ile Lys Glu Leu Ala Arg Thr His Phe
355 360 365Thr Asn Tyr Pro Val Arg Leu Ala Ala Pro Val Glu Lys Tyr Asn Ile
370 375 380Met Gly Met Phe Glu Asp Leu Lys Asp Pro Arg Phe Ser Val Val Val385 390 395 400Gly Leu Ile Leu Tyr Lys Ala Gly Gly His Thr Asn Tyr Glu Arg Asp
405 410 415Ser Lys Gly Val Ile Arg Tyr His Glu Ser Asp Asp Tyr Thr Arg Thr
420 425 430Ala His Gln Ser Ser Pro Thr Pro His Ile His Ser Ser Pro Thr Glu
435 440 445Arg Asn Leu Ser Asp Leu Lys Ala Pro Ser Ala Pro Leu Asn Thr Ala
450 455 460Lys Asn Asp Asp Phe Leu Pro Ile Lys Pro Thr Glu Gln Lys Gly Phe465 470 475 480Phe Lys Ser Phe Leu Asp Lys Ile Ser Lys Phe Phe
485 490
(2) Data in sequence 143:
(i) sequence characteristics:
(A) length: 1987bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1934
(D) Other information:
(xi) Description of the sequence: sequence 143: AGCGCTTGAA ATTTTTAGCC ATTTATGACA CGAATTTAGA CGAATTTTAC ATG ATA 56
Met Ile
1AGA GTG GCA GGG CTT AAA CAA CTC TAT GAG CAT AAA ATC GCC TCT AAA 104Arg Val Ala Gly Leu Lys Gln Leu Tyr Glu His Lys Ile Ala Ser Lys
5 10 15GGC ATT GAT GGC GCA AGC CCT GAA GAA CAA TTA GAA AAA ATC AAG CAT 152Gly Ile Asp Gly Ala Ser Pro Glu Glu Gln Leu Glu Lys Ile Lys His
20 25 30TAT TTA GCG CAT GAA ATT GAA GAA AGG GAG TTA GAA TTC CAA AAA ATC 200Tyr Leu Ala His Glu Ile Glu Glu Arg Glu Leu Glu Phe Gln Lys Ile35 40 45 50CAA GCC CTA CTC TTT AAA AAA GGG CTT TGT ATC ACC CCC TAT AAT GAA 248Gln Ala Leu Leu Phe Lys Lys Gly Leu Cys Ile Thr Pro Tyr Asn Glu
55 60 65TTG AAT TTA GAG CAA AAA GCG AAG GCT AAA ACC TAT TTT AAA GAG CAG 296Leu Asn Leu Glu Gln Lys Ala Lys Ala Lys Thr Tyr Phe Lys Glu Gln
70 75 80CTT TAC GCG TTA GTT TTG CCT TTT AAA TTG GAT TCT TCA CAC ACT TTC 344Leu Tyr Ala Leu Val Leu Pro Phe Lys Leu Asp Ser Ser His Thr Phe
85 90 95CCG CCT TTA GCG AAT TTG ACT TTC GCG CTT TTT GCC CGC ATC AAA GAC 392Pro Pro Leu Ala Asn Leu Thr Phe Ala Leu Phe Ala Arg Ile Lys Asp
100 105 110AAA GAA ACC CAA ATT ATC TCC TAT GCG CTC ATC AAA CTC CCC TCT TTT 440Lys Glu Thr Gln Ile Ile Ser Tyr Ala Leu Ile Lys Leu Pro Ser Phe115 120 125 130ATC TTCCGT TTT GTA GAG CTA GAA AAA GGC TTG TTT GTG TTA GCT GAA 488Ile Phe Arg Phe Val Glu Leu Glu Lys Gly Leu Phe Val Leu Ala Glu
135 140 145GAA ATC GTG GAA GCG CAT TTA GAA GAA TTG TTT TTA GAG CAT GAG ATT 536Glu Ile Val Glu Ala His Leu Glu Glu Leu Phe Leu Glu His Glu Ile
150 155 160TTA GAT TGC ATG GCG TTT AGG GTA ACT TGC GAT GCG GAT ATT GCT ATC 584Leu Asp Cys Met Ala Phe Arg Val Thr Cys Asp Ala Asp Ile Ala Ile
165 170 175ACT GAA GAT GAA GCG CAT GAT TAT GCA GAT TTG ATG AGT AAG AGT TTG 632Thr Glu Asp Glu Ala His Asp Tyr Ala Asp Leu Met Ser Lys Ser Leu
180 185 190AGG AAA CGC AAT CAA GGC GAA ATC GTG CGC TTG CAA ACC CAA AAA GGG 680Arg Lys Arg Asn Gln Gly Glu Ile Val Arg Leu Gln Thr Gln Lys Gly195 200 205 210AGT CAA GAG CTT TTA AAA ACC CTC TTA GCG TCT TTA AGG AGT TTT CAA 728Ser Gln Glu Leu Leu Lys Thr Leu Leu Ala Ser Leu Arg Ser Phe Gln
215 220 225ACC CAC TCT TAC AAA AAG CAC AAA CTC ACC GGC ATG CAT ATC TAT AAA 776Thr His Ser Tyr Lys Lys His Lys Leu Thr Gly Met His Ile Tyr Lys
230 235 240AGC GCG ATC ATG CTC AAT TTA GGG GAT TTG TGG GAA TTA GTC AAT CAT 824Ser Ala Ile Met Leu Asn Leu Gly Asp Leu Trp Glu Leu Val Asn His
245 250 255AGC GAT TTT AAA GCG CTC AAA TCG CCC AAT TTC ACA CCC AAA ATC CAC 872Ser Asp Phe Lys Ala Leu Lys Ser Pro Asn Phe Thr Pro Lys Ile His
260 265 270CCT CAT TTC AAT GAA AAC GAT CTT TTC AAA TCT ATA GAA AAA CAG GAT 920Pro His PheAsn Glu Asn Asp Leu Phe Lys Ser Ile Glu Lys Gln Asp275 280 285 290CTG TTG CTG TTT CAT CCT TAT GAA AGT TTT GAG CCT GTG ATT GAT TTA 968Leu Leu Leu Phe His Pro Tyr Glu Ser Phe Glu Pro Val Ile Asp Leu
295 300 305ATA GAG CAA CCC GCT AGC GAT CCA GCC ACC CTT TCT ATC AAA ATG ACG 1016Ile Glu Gln Ala Ala Ser Asp Pro Ala Thr Leu Ser Ile Lys Met Thr
310 315 320CTT TAT CGT GTG GGC AAG CAT TCC CCC ATT GTC AAA GCT TTG ATT GAA 1064Leu Tyr Arg Val Gly Lys His Ser Pro Ile Val Lys Ala Leu Ile Glu
325 330 335GCG GCG AGC AAG ATT CAA GTG AGC GTT TTA GTG GAA TTA AAA GCG CGC 1112Ala Ala Ser Lys Ile Gln Val Ser Val Leu Val Glu Leu Lys Ala Arg
340 345 350TTT GAT GAA GAG AGC AAT CTG CAC TGG GCA AAA GCT TTA GAA AGG GCG 1160Phe Asp Glu Glu Ser Asn Leu His Trp Ala Lys Ala Leu Glu Arg Ala355 360 365 370GGC GCG TTA GTC GTT TAT GGC GTT TTC AAA CTC AAA GTG CAT GCT AAA 1208Gly Ala Leu Val Val Tyr Gly Val Phe Lys Leu Lys Val His Ala Lys
375 380 385ATG CTA TTG ATC ACT AAA AAA ACA GAC AAC CAA TTA CGC CAT TTC ACC 1256Met Leu Leu Ile Thr Lys Lys Thr Asp Asn Gln Leu Arg His Phe Thr
390 395 400CAT TTA AGC ACG GGC AAT TAC AAC CCT TTG AGC GCT AAA GTC TAT ACC 1304His Leu Ser Thr Gly Asn Tyr Asn Pro Leu Ser Ala Lys Val Tyr Thr
405 410 415GAT GTG AGT TTT TTT AGC GCT AAA AAT GAA ATC GCT AAC GAC ATT ATC 1352Asp Val Ser Phe Phe Ser Ala Lys Asn Glu Ile Ala Asn Asp Ile Ile
420 425 430AAG CTT TTC CAT TCC TTG CTC ACT AGC AGC GCG ACT AAT AGC GCA TTA 1400Lys Leu Phe His Ser Leu Leu Thr Ser Ser Ala Thr Asn Ser Ala Leu435 440 445 450GAA ACG CTT TTT ATG GCA CCC AAA CAA ATC AAG CCT AAA ATC ATT GAA 1448Glu Thr Leu Phe Met Ala Pro Lys Gln Ile Lys Pro Lys Ile Ile Glu
455 460 465CTC ATT CAA AAT GAA ATG AAT CAC CAA CAA GAA GGC TAT ATC ATT TTA 1496Leu Ile Gln Asn Glu Met Asn His Gln Gln Glu Gly Tyr Ile Ile Leu
470 475 480AAA GCC AAC GCC CTA GTG GAT AGC GAA ATC ATT GAA TGG CTC TAT CAA 1544Lys Ala Asn Ala Leu Val Asp Ser Glu Ile Ile Glu Trp Leu Tyr Gln
485 490 495GCC TCT CAA AAA GGG GTT AAA ATT GAT CTC ATT ATT AGA GGG ATT TGC 1592Ala Ser Gln Lys Gly Val Lys Ile Asp Leu Ile Ile Arg Gly Ile Cys
500 505 510TGT TTA AAG CCC CAA GTC AAG GGC TTG AGC GAA AAT ATC AGG GTG TAT 1640Cys Leu Lys Pro Gln Val Lys Gly Leu Ser Glu Asn Ile Arg Val Tyr515 520 525 530TCT ATC GTG GGG AAA TAT TTA GAA CAT GCA CGC ATT TAT TAT TTT AAA 1688Ser Ile Val Gly Lys Tyr Leu Glu His Ala Arg Ile Tyr Tyr Phe Lys
535 540 545CAT GAA AAT ATT TAT TTT TCT AGC GCG GAT TTA ATG CCC AGG AAT TTA 1736His Glu Asn Ile Tyr Phe Ser Ser Ala Asp Leu Met Pro Arg Asn Leu
550 555 560GAA AGG CGC GTG GAA TTG CTC ATT CCA GCC ACA AAC CCA AAG ATC GCT 1784Glu Arg Arg Val Glu Leu Leu Ile Pro Ala Thr Asn Pro Lys Ile Ala
565 570 575CAT AAA TTG TTG CAT ATT TTA GAA ATC CAA CTC AAA GAC ACC TTA AAA 1832His Lys Leu Leu His Ile Leu Glu Ile Gln Leu Lys Asp Thr Leu Lys
580 585 590CGC TAC GAG TTA AAT TCT AAA GGC CGT TAC ATT AAA GTT TCA AAC CCT 1880Arg Tyr Glu Leu Asn Ser Lys Gly Arg Tyr Ile Lys Val Ser Asn Pro595 600 605 610AAC GAT CCT TTA AAT TCG CAG GAT TAT TTT GAA AAA CAA GCC CTT AAA 1928Asn Asp Pro Leu Asn Ser Gln Asp Tyr Phe Glu Lys Gln Ala Leu Lys
615 620 625ACC TTT TAAGGGTTAT CGTTCAAATC ATAAAAGATA AGGATTTAAA TGCTTTATTC AT 1986Thr PheT 1987
(2) Sequence 144 data:
(i) sequence characteristics:
(A) length: 628 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 144: met Ile Arg Val Ala Gly Leu Lys Gln Leu Tyr Glu His Lys Ile Ala 151015 Ser Lys Gly Ile Asp Gly Ala Ser Pro Glu Glu Gln Leu Glu Lys Ile
20 25 30Lys His Tyr Leu Ala His Glu Ile Glu Glu Arg Glu Leu Glu Phe Gln
35 40 45Lys Ile Gln Ala Leu Leu Phe Lys Lys Gly Leu Cys Ile Thr Pro Tyr
50 55 60Asn Glu Leu Asn Leu Glu Gln Lys Ala Lys Ala Lys Thr Tyr Phe Lys65 70 75 80Glu Gln Leu Tyr Ala Leu Val Leu Pro Phe Lys Leu Asp Ser Ser His
85 90 95Thr Phe Pro Pro Leu Ala Asn Leu Thr Phe Ala Leu Phe Ala Arg Ile
100 105 110Lys Asp Lys Glu Thr Gln Ile Ile Ser Tyr Ala Leu Ile Lys Leu Pro
115 120 125Ser Phe Ile Phe Arg Phe Val Glu Leu Glu Lys Gly Leu Phe Val Leu
130 135 140Ala Glu Glu Ile Val Glu Ala His Leu Glu Glu Leu Phe Leu Glu His145 150 155 160Glu Ile Leu Asp Cys Met Ala Phe Arg Val Thr Cys Asp Ala Asp Ile
165 170 175Ala Ile Thr Glu Asp Glu Ala His Asp Tyr Ala Asp Leu Met Ser Lys
180 185 190Ser Leu Arg Lys Arg Asn Gln Gly Glu Ile Val Arg Leu Gln Thr Gln
195 200 205Lys Gly Ser Gln Glu Leu Leu Lys Thr Leu Leu Ala Ser Leu Arg Ser
210 215 220Phe Gln Thr His Ser Tyr Lys Lys His Lys Leu Thr Gly Met His Ile225 230 235 240Tyr Lys Ser Ala Ile Met Leu Asn Leu Gly Asp Leu Trp Glu Leu Val
245 250 255Asn His Ser Asp Phe Lys Ala Leu Lys Ser Pro Asn Phe Thr Pro Lys
260 265 270Ile His Pro His Phe Asn Glu Asn Asp Leu Phe Lys Ser Ile Glu Lys
275 280 285Gln Asp Leu Leu Leu Phe His Pro Tyr Glu Ser Phe Glu Pro Val Ile
290 295 300Asp Leu Ile Glu Gln Ala Ala Ser Asp Pro Ala Thr Leu Ser Ile Lys305 310315 320Met Thr Leu Tyr Arg Val Gly Lys His Ser Pro Ile Val Lys Ala Leu
325 330 335Ile Glu Ala Ala Ser Lys Ile Gln Val Ser Val Leu Val Glu Leu Lys
340 345 350Ala Arg Phe Asp Glu Glu Ser Asn Leu His Trp Ala Lys Ala Leu Glu
355 360 365Arg Ala Gly Ala Leu Val Val Tyr Gly Val Phe Lys Leu Lys Val His
370 375 380Ala Lys Met Leu Leu Ile Thr Lys Lys Thr Asp Asn Gln Leu Arg His385 390 395 400Phe Thr His Leu Ser Thr Gly Asn Tyr Asn Pro Leu Ser Ala Lys Val
405 410 415Tyr Thr Asp Val Ser Phe Phe Ser Ala Lys Asn Glu Ile Ala Asn Asp
420 425 430Ile Ile Lys Leu Phe His Ser Leu Leu Thr Ser Ser Ala Thr Asn Ser
435 440 445Ala Leu Glu Thr Leu Phe Met Ala Pro Lys Gln Ile Lys Pro Lys Ile
450 455 460Ile Glu Leu Ile Gln Asn Glu Met Asn His Gln Gln Glu Gly Tyr Ile465 470 475 480Ile Leu Lys Ala Asn Ala Leu Val Asp Ser Glu Ile Ile Glu Trp Leu
485 490 495Tyr Gln Ala Ser Gln Lys Gly Val Lys Ile Asp Leu Ile Ile Arg Gly
500 505 510Ile Cys Cys Leu Lys Pro Gln Val Lys Gly Leu Ser Glu Asn Ile Arg
515 520 525Val Tyr Ser Ile Val Gly Lys Tyr Leu Glu His Ala Arg Ile Tyr Tyr
530 535 540Phe Lys His Glu Asn Ile Tyr Phe Ser Ser Ala Asp Leu Met Pro Arg545 550 555 560Asn Leu Glu Arg Arg Val Glu Leu Leu Ile Pro Ala Thr Asn Pro Lys
565 570 575Ile Ala His Lys Leu Leu His Ile Leu Glu Ile Gln Leu Lys Asp Thr
580 585 590Leu Lys Arg Tyr Glu Leu Asn Ser Lys Gly Arg Tyr Ile Lys Val Ser
595 600 605Asn Pro Asn Asp Pro Leu Asn Ser Gln Asp Tyr Phe Glu Lys Gln Ala
610 615 620Leu Lys Thr Phe625
(2) Sequence 145 data:
(i) sequence characteristics:
(A) length: 616bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...563
(D) Other information:
(xi) Description of the sequence: sequence 145: TATAATATAG ATTTTATTTT AGCTAAAAAT GGCATGGGTT TTAGCAAGGA ATG GGC 56
Met Gly
1TTG AAA AAT CTC TCA ACA CTT CTG GTG TTT TTA TTC TTT TGT TTA GGG 104Leu Lys Asn Leu Ser Thr Leu Leu Val Phe Leu Phe Phe Cys Leu Gly
5 1015TGT GTG AGC AAT TTT AAT GAA GAC ACT TAC ACG CTA GAC TTA GTT TTA 152Cys Val Ser Asn Phe Asn Glu Asp Thr Tyr Thr Leu Asp Leu Val Leu
20 25 30GAA AAA AAG ATC CAA GCC AGC AGG AAA GGT GAA ATC ACC CAA GAT AAT 200Glu Lys Lys Ile Gln Ala Ser Arg Lys Gly Glu Ile Thr Gln Asp Asn35 40 45 50GTG CCT ATC ATC ACG GCT ATC GCT ACG CAT TTA AAC GAT GTG GAT AGC 248Val Pro Ile Ile Thr Ala Ile Ala Thr His Leu Asn Asp Val Asp Ser
55 60 65GGC ACT TAC TAT GAC CAT GAG TAT TTT TTA GTG GAG ATT TTC ACG CAA 296Gly Thr Tyr Tyr Asp His Glu Tyr Phe Leu Val Glu Ile Phe Thr Gln
70 75 80AAT AAC GAC TGG ATA GAT GAT GGC TAT ATT TCT TAT GAA CTT TTT GGC 344Asn Asn Asp Trp Ile Asp Asp Gly Tyr Ile Ser Tyr Glu Leu Phe Gly
85 90 95ACA AAA CCT ATA GGC TCA GAG CCT TTA TGG GTG CGA GAA ATC ACA AAA 392Thr Lys Pro Ile Gly Ser Glu Pro Leu Trp Val Arg Glu Ile Thr Lys
100 105 110GAT GAA TTT GAT GGC ATT TTA GAA ACC ACG AAC AGG TGG AGC AGA GCT 440Asp Glu Phe Asp Gly Ile Leu Glu Thr Thr Asn Arg Trp Ser Arg Ala115 120 125 130TTT TTG CTC GCT TTT AAC AAA TTG GAT TAT TTA GCG GTT CAA GAA GCC 488Phe Leu Leu Ala Phe Asn Lys Leu Asp Tyr Leu Ala Val Gln Glu Ala
135 140 145AAA CTA GAG CTT GAT GCC TAT AGT TTG GGC AAG ATT GTT TTT AAT TTC 536Lys Leu Glu Leu Asp Ala Tyr Ser Leu Gly Lys Ile Val Phe Asn Phe
150 155 160GCT TAT CAA GTC CCC CTA CCT CAA TTT TAATGCGCTT AGATTACGCC TTATTCA 590Ala Tyr Gln ValPro Leu Pro Gln Phe
165 170GTCAGCATTT AGTAAATAGC AGAGAA 616
(2) Sequence 146 data:
(i) sequence characteristics:
(A) length: 171 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 146: met Gly Leu Lys Asn Leu Ser Thr Leu Leu Val Phe Leu Phe Phe Cys 151015 Leu Gly Cys Val Ser Asn Phe Asn Glu Asp Thr Tyr Thr Leu Asp Leu
20 25 30Val Leu Glu Lys Lys Ile Gln Ala Ser Arg Lys Gly Glu Ile Thr Gln
35 40 45Asp Asn Val Pro Ile Ile Thr Ala Ile Ala Thr His Leu Asn Asp Val
50 55 60Asp Ser Gly Thr Tyr Tyr Asp His Glu Tyr Phe Leu Val Glu Ile Phe65 70 75 80Thr Gln Asn Asn Asp Trp Ile Asp Asp Gly Tyr Ile Ser Tyr Glu Leu
85 90 95Phe Gly Thr Lys Pro Ile Gly Ser Glu Pro Leu Trp Val Arg Glu Ile
100 105 110Thr Lys Asp Glu Phe Asp Gly Ile Leu Glu Thr Thr Asn Arg Trp Ser
115 120 125Arg Ala Phe Leu Leu Ala Phe Asn Lys Leu Asp Tyr Leu Ala Val Gln
130 135 140Glu Ala Lys Leu Glu Leu Asp Ala Tyr Ser Leu Gly Lys Ile Val Phe145150 155 160Asn Phe Ala Tyr Gln Val Pro Leu Pro Gln Phe
165 170
(2) Sequence 147 data:
(i) sequence characteristics:
(A) length: 2341bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 966...2291
(D) Other information:
(xi) Description of the sequence: sequence 147: ATTGTGAATT AGGAGTGAGC GTGAATAGTA ATGGCAATAA AGACAAACAA CAGCAGAATG 60TAAGCAGTGG GATTTCTCAA ATCTCATTAA AAAAGGTGGC AACTTTTGAT GAAAATGGGG 120CGAGTTTTGA GAATTTAAAT TCTATCAACT TTATTTATGG GGCTAATGGG AGCGGTAAGA 180CAACCACTTC TAGTTTTTTA AAAAATCTAG CTGAAAATGG GATTGAAGAC AAGTTTGCTA 240ATAGTAAAAT AGCATGGTAT AACAATGAGA GTTTAAAGAT TGAAGTTTAT AACAAGCAAT 300TTAAAGAAGA GCAATTGAGA AACTCTCAAG TTAAAGGCAT TTTTACGCTC GGTAAAAAAA 360CGAACGAGAA TTTAGAAAAA ATTGAAAGCA AGAAAGAATC AATAAACAAA GAGAATGAAA 420AGAAAATAAA AAATGAAGCA AGCTTGCAAG TTTTAACACA AAAAAAGGAA AAGGAAGAAA 480AGGATTTTGC TGATAGGTGT TGGGAAAAAC TTTATAAGAA AAATGAAGAG GATTTTAAAG 540AAACGCTAGA AGGCTTTAAG CGTAAAGAGA AGTTTAAAGA AAAAATCCTT AAGGAATTTG 600AAAACGATAA ATACAATCAA AGCGAAATAG TAGGGTTAGA AAAATTAAAG GAAAAAATTG 660AGATTGTTTT TGGTGAAAAC CAAACAGAAT TGGCACTATT GGAATGCAAT TTAACAGATT 720TTGATTTTAT TGAAAATCAT TCTATTTGGG AACAAAAAAT TGTAGGGAGT GGTGATGCAG 780CCATTGCAGA TTTAATAAAA AGATTAAGCA ATGAAGATTG GGTAGCTCAA GGTAGAGAAT 840ATATAAAAGA TAATAGTATA TGCCCTTTCT GTCAAAAAGA AACCATTACC GAAGAATTTA 900AAAAACAACT AGAATCTTAT TTTGATACAA GTTATCAAGA ATCTATTGAA ACGATCAAGG 960AAAAG ATG GAA GAC TAC GCA AGC AGA ACC GCT GGA GCA CTG GAG CGA CTT 1010
Met Glu Asp Tyr Ala Ser Arg Thr Ala Gly Ala Leu Glu Arg Leu
1 5 10 15GAT AAG ATT GTT GAA ACA GAA CAG AAG AAT CAA CAA ACT AAA TTG GAC 1058Asp Lys Ile Val Glu Thr Glu Gln Lys Asn Gln Gln Thr Lys Leu Asp
20 25 30ACA GAA AAT TTG AAA ATA ATT ATT GAA ACT TTG AGA AGT AAA ATC AAT 1106Thr Glu Asn Leu Lys Ile Ile Ile Glu Thr Leu Arg Ser Lys Ile Asn
35 40 45GGG AAT CAG CAA AAG ATG CTT GAT AAA AGT AAA GAA ATG AGC AGA AAT 1154Gly Asn Gln Gln Lys Met Leu Asp Lys Ser Lys Glu Met Ser Arg Asn
50 55 60TTT AAG CTT GAT AGC ACT AAA AAC GAG ATA GAC GCA ATT AAA GAT TTG 1202Phe Lys Leu Asp Ser Thr Lys Asn Glu Ile Asp Ala Ile Lys Asp Leu
65 70 75ATT AAA AAG GCT AAT GAG CAA ATA GCC AAT TAT AAT GAG ATG ATA AAG 1250Ile Lys Lys Ala Asn Glu Gln Ile Ala Asn Tyr Asn Glu Met Ile Lys80 85 90 95GAT ATT GAA AAA CAG AAA AAG AGT TGT AAG GAA CAA ACT TGG AAA TTT 1298Asp Ile Glu Lys Gln Lys Lys Ser Cys Lys Glu Gln Thr Trp Lys Phe
100 105 110CTA GTC AAT GAA TTT AAA AGT GAT ATA CAA GAA TAT AAT AAA AAG TAT 1346Leu Val Asn Glu Phe Lys Ser Asp Ile Gln Glu Tyr Asn Lys Lys Tyr
115 120 125TGC GGT TTG GAG AAA GGA ATA AAC AAT TTA GAG AAA GCA ATT AGT GAA 1394Cys Gly Leu Glu Lys Gly Ile Asn Asn Leu Glu Lys Ala Ile Ser Glu
130 135 140AAT CAAGAA GAG GTA AAG AAA TTA GAA AAT GAA ATT AAG GAA TTA GAA 1442Asn Gln Glu Glu Val Lys Lys Leu Glu Asn Glu Ile Lys Glu Leu Glu
145 150 155AAA ACT ATG GTA AGC ATA AAG CCC ATT GTC AAT GAA ATC AAT ACG CTT 1490Lys Thr Met Val Ser Ile Lys Pro Ile Val Asn Glu Ile Asn Thr Leu160 165 170 175TTA AAA GGG TAT GGA TTC GCG AAT TTT AGT TTG GCA TGC ACT GAA GAT 1538Leu Lys Gly Tyr Gly Phe Ala Asn Phe Ser Leu Ala Cys Thr Glu Asp
180 185 190GAA AAA TTT TAT CGT ATT CAA AGA GAA GAT GGT CAA TTA GTA GGA GAA 1586Glu Lys Phe Tyr Arg Ile Gln Arg Glu Asp Gly Gln Leu Val Gly Glu
195 200 205ACA CTG AGC GAG GGT GAA GTT ACT TTC ATC ACT TTC TTA TAT TAT TAT 1634Thr Leu Ser Glu Gly Glu Val Thr Phe Ile Thr Phe Leu Tyr Tyr Tyr
210 215 220CAT TTA GCA AAA GGC TCT TTA GAA GAG AAC GAT ATA TCA AAA AAT AAG 1682His Leu Ala Lys Gly Ser Leu Glu Glu Asn Asp Ile Ser Lys Asn Lys
225 230 235GTT TTA GTG ATT GAT GAC CCC ATT TCA AGT TTG GAT AGC AAT ATA TTG 1730Val Leu Val Ile Asp Asp Pro Ile Ser Ser Leu Asp Ser Asn Ile Leu240 245 250 255TTT ATA GTG AGT GTT TTA GTT AAA GAT CTT ATG AAA GAA GCC ATG GAA 1778Phe Ile Val Ser Val Leu Val Lys Asp Leu Met Lys Glu Ala Met Glu
260 265 270GAA AAA ACA AAC ATC AAG CAA GTT ATT ATA CTA ACC CAC AAC ACA TAT 1826Glu Lys Thr Asn Ile Lys Gln Val Ile Ile Leu Thr His Asn Thr Tyr
275 280 285TTT TAC AAG GAA ATT ACA TTA GAA TGT GAT TTA AAA CGC TAT CAA GGG 1874Phe Tyr Lys Glu Ile Thr Leu Glu Cys Asp Leu Lys Arg Tyr Gln Gly
290 295 300AAA TAT TCT TTT TGG ATA ATT AAA AAG GAT AAT AAT GTT TCA AAA ATT 1922Lys Tyr Ser Phe Trp Ile Ile Lys Lys Asp Asn Asn Val Ser Lys Ile
305 310 315AAA GAT TAT AAA GAA AAT CCC ATT AAA AAT TCC TAT GAA TTG CTA TGG 1970Lys Asp Tyr Lys Glu Asn Pro Ile Lys Asn Ser Tyr Glu Leu Leu Trp320 325 330 335CAA GAA GTA AAA CAA GCA AAA GAA AAT AAT GCT TCT TGG GTA TCT TTA 2018Gln Glu Val Lys Gln Ala Lys Glu Asn Asn Ala Ser Trp Val Ser Leu
340 345 350CAA AAT GTT ATG CGA AGA ATT ATT GAG TAT TAC TTT AGG ATT TTA GGC 2066Gln Asn Val Met Arg Arg Ile Ile Glu Tyr Tyr Phe Arg Ile Leu Gly
355 360 365GGT TTT AAA CAT AAT GAT AGC TTG AGT GAA TGT TTT GAA AAT ATT GAA 2114Gly Phe Lys His Asn Asp Ser Leu Ser Glu Cys Phe Glu Asn Ile Glu
370 375 380GAA AAA CGA GTG TGT AAT TCT TTC ATT TCA TGG TTT AAT GAT GGC TCT 2162Glu Lys Arg Val Cys Asn Ser Phe Ile Ser Trp Phe Asn Asp Gly Ser
385 390 395CAT GGG ATT TCA GAT GAT TTG TTT ATG CAA AGT CAA GAT ACA AGT ATT 2210His Gly Ile Ser Asp Asp Leu Phe Met Gln Ser Gln Asp Thr Ser Ile400 405 410 415GAG ACA TAT TTA AAA GTT TTT GAA AAA ATA TTT AAA GAA ACC GGT CAT 2258Glu Thr Tyr Leu Lys Val Phe Glu Lys Ile Phe Lys Glu Thr Gly His
420 425 430GAA GCT CAT TAT AAA ATG ATG ATG AGA ATG AAG TAATTGAATT AAAAACAAGG 2311Glu Ala His Tyr Lys Met Met Met Arg Met Lys
435 440AATAACATGC GAATCGTATT TATGGGAACG 2341
(2) Sequence 148 data:
(i) sequence characteristics:
(A) length: 442 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 148: met Glu Asp Tyr Ala Ser Arg Thr Ala Gly Ala Leu Glu Arg Leu Asp 151015 Lys Ile Val Glu Thr Glu Gln Lys Asn Gln Gln Thr Lys Leu Asp Thr
20 25 30Glu Asn Leu Lys Ile Ile Ile Glu Thr Leu Arg Ser Lys Ile Asn Gly
35 40 45Asn Gln Gln Lys Met Leu Asp Lys Ser Lys Glu Met Ser Arg Asn Phe
50 55 60Lys Leu Asp Ser Thr Lys Asn Glu Ile Asp Ala Ile Lys Asp Leu Ile65 70 75 80Lys Lys Ala Asn Glu Gln Ile Ala Asn Tyr Asn Glu Met Ile Lys Asp
85 90 95Ile Glu Lys Gln Lys Lys Ser Cys Lys Glu Gln Thr Trp Lys Phe Leu
100 105 110Val Asn Glu Phe Lys Ser Asp Ile Gln Glu Tyr Asn Lys Lys Tyr Cys
115 120 125Gly Leu Glu Lys Gly Ile Asn Asn Leu Glu Lys Ala Ile Ser Glu Asn
130 135 140Gln Glu Glu Val Lys Lys Leu Glu Asn Glu Ile Lys Glu Leu Glu Lys145 150 155 160Thr Met Val Ser Ile LysPro Ile Val Asn Glu Ile Asn Thr Leu Leu
165 170 175Lys Gly Tyr Gly Phe Ala Asn Phe Ser Leu Ala Cys Thr Glu Asp Glu
180 185 190Lys Phe Tyr Arg Ile Gln Arg Glu Asp Gly Gln Leu Val Gly Glu Thr
195 200 205Leu Ser Glu Gly Glu Val Thr Phe Ile Thr Phe Leu Tyr Tyr Tyr His
210 215 220Leu Ala Lys Gly Ser Leu Glu Glu Asn Asp Ile Ser Lys Asn Lys Val225 230 235 240Leu Val Ile Asp Asp Pro Ile Ser Ser Leu Asp Ser Asn Ile Leu Phe
245 250 255Ile Val Ser Val Leu Val Lys Asp Leu Met Lys Glu Ala Met Glu Glu
260 265 270Lys Thr Asn Ile Lys Gln Val Ile Ile Leu Thr His Asn Thr Tyr Phe
275 280 285Tyr Lys Glu Ile Thr Leu Glu Cys Asp Leu Lys Arg Tyr Gln Gly Lys
290 295 300Tyr Ser Phe Trp Ile Ile Lys Lys Asp Asn Asn Val Ser Lys Ile Lys305 310 315 320Asp Tyr Lys Glu Asn Pro Ile Lys Asn Ser Tyr Glu Leu Leu Trp Gln
325 330 335Glu Val Lys Gln Ala Lys Glu Asn Asn Ala Ser Trp Val Ser Leu Gln
340 345 350Asn Val Met Arg Arg Ile Ile Glu Tyr Tyr Phe Arg Ile Leu Gly Gly
355 360 365Phe Lys His Asn Asp Ser Leu Ser Glu Cys Phe Glu Asn Ile Glu Glu
370 375 380Lys Arg Val Cys Asn Ser Phe Ile Ser Trp PheAsn Asp Gly Ser His385 390 395 400Gly Ile Ser Asp Asp Leu Phe Met Gln Ser Gln Asp Thr Ser Ile Glu
405 410 415Thr Tyr Leu Lys Val Phe Glu Lys Ile Phe Lys Glu Thr Gly His Glu
420 425 430Ala His Tyr Lys Met Met Met Arg Met Lys
435 440
(2) Sequence 149 data:
(i) sequence characteristics:
(A) length: 3793bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...3740
(D) Other information:
(xi) Description of the sequence: sequence 149: TTATGTGGGC TACAACATAG GCTTTTGATT AAACAAAATA AGGGAAAAAT ATG ATA 56
Met Ile
1AAA AAA GCT AGA AAA TTC ATA CCA TTC TTT TTA ATT GGC TCC CTC TTA 104Lys Lys Ala Arg Lys Phe Ile Pro Phe Phe Leu Ile Gly Ser Leu Leu
5 10 15GCT GAA GAC AAT GGC TGG TAT ATG TCT GTA GGC TAT CAA ATC GGT GGC 152Ala Glu Asp Asn Gly Trp Tyr Met Ser Val Gly Tyr Gln Ile Gly Gly
20 25 30ACG CAA CAA TTC ATC AAT AAC AAA CAA CTT TTA GAA AAT CAA AAT ATC 200Thr Gln Gln Phe Ile Asn Asn Lys Gln Leu Leu Glu Asn Gln Asn Ile35 40 45 50ATC AAC AGC GTA ACC CAA AGC GCG ATC AAC ATT GCA GGG CCT ACT ACC 248Ile Asn Ser Val Thr Gln Ser Ala Ile Asn Ile Ala Gly Pro Thr Thr
55 60 65GGC CTT ATC ACT TTA AGC TCT CAA ACC GTC ATT GAC GCT TTA GGC TAT 296Gly Leu Ile Thr Leu Ser Ser Gln Thr Val Ile Asp Ala Leu Gly Tyr
70 75 80GGC GTG AGT AAC ACT GTT GGC AAC CAA TTA GAG GGC ATT TCT AAT ATC 344Gly Val Ser Asn Thr Val Gly Asn Gln Leu Glu Gly Ile Ser Asn Ile
85 90 95TTG AAT CAA ATT GGC AAA AGA AAA GAC TTT TAT TCT AGC CGT CAA ATC 392Leu Asn Gln Ile Gly Lys Arg Lys Asp Phe Tyr Ser Ser Arg Gln Ile
100 105 110TCT AGC ATT TCC CAA CAA ATC ATA GGG CTT AAA GGA AGC TCT GAT CCC 440Ser Ser Ile Ser Gln Gln Ile Ile Gly Leu Lys Gly Ser Ser Asp Pro115 120 125 130TTA AAA GCC CAT TCT TCA CAG ATC ACA GCC AAA CTC CTT TCC AAC ACC 488Leu Lys Ala His Ser Ser Gln Ile Thr Ala Lys Leu Leu Ser Asn Thr
135 140 145CAA AGC GCG TTT GAT CAG GGC ATC GCG CTA AGC ACT AAC ATC ATT AGC 536Gln Ser Ala Phe Asp Gln Gly Ile Ala Leu Ser Thr Asn Ile Ile Ser
150 155 160TCT ATC AAT AGC CTA AAC CCT AGC AAC AAC ACC CAA GAG GTT AAA AAA 584Ser Ile Asn Ser Leu Asn Pro Ser Asn Asn Thr Gln Glu Val Lys Lys
165 170 175CAG CTC CAA AAC ACC GCG CAA TCC ATG ACA GAA TTG TTG CAA CAA ATT 632Gln Leu Gln Asn Thr Ala Gln Ser Met Thr Glu Leu Leu Gln Gln Ile
180 185 190GAA CAC AGC ATC ACT AAA ACC ACT AGC ACC ACT TAC GCG CAA TCC TTA 680Glu His Ser Ile Thr Lys Thr Thr Ser Thr Thr Tyr Ala Gln Ser Leu195 200 205 210CTC TCC AAT CTA ACC GAT GCG GTG AAT GCC TCT AGC AAT AAT ACC GCT 728Leu Ser Asn Leu Thr Asp Ala Val Asn Ala Ser Ser Asn Asn Thr Ala
215 220 225TAT GTG AGC GCT CTT GTT AAC GCT TTA AAC ACT TTA GGG GTA GGG GTT 776Tyr Val Ser Ala Leu Val Asn Ala Leu Asn Thr Leu Gly Val Gly Val
230 235 240TTC CCC ACC ACA ACC ACA ACG CAT GTG GTG TTA AAC CCA CCG GGA CAA 824Phe Pro Thr Thr Thr Thr Thr His Val Val Leu Asn Pro Pro Gly Gln
245 250 255GTC GTA TTC TAT CCA ACC AAT TCC ATT TTA GGC TCT ACT TCT TCA AAC 872Val Val Phe Tyr Pro Thr Asn Ser Ile Leu Gly Ser Thr Ser Ser Asn
260 265 270AGC AAT AAC CAA CAA CAA TAC AAC AAC ACC CTT TTA ATG AAC ACC TTA 920Ser Asn Asn Gln Gln Gln Tyr Asn Asn Thr Leu Leu Met Asn Thr Leu275 280 285 290CAA GGG ACA TTA AGC GCT AAT ACT CAA AAT AAC CCC AAT GGT TGC GCC 968Gln Gly Thr Leu Ser Ala Asn Thr Gln Asn Asn Pro Asn Gly Cys Ala
295 300 305AAT CAA GTC CAG TGT TTG GAG CAA TTC ATC CAA AAT TTA GCC CCT TTA 1016Asn Gln Val Gln Cys Leu Glu Gln Phe Ile Gln Asn Leu Ala Pro Leu
310 315 320GCC GCA ACC CCC ACT TCA AAC AAC CAG GCC AAC CAG CAA GTC CAA GCC 1064Ala Ala Thr Pro Thr Ser Asn Asn Gln Ala Asn Gln Gln Val Gln Ala
325 330 335ATC GCT CAA AAG CTT CAA AGC GTT GCT ATC AAC ACTTTA GAC AAC AAT 1112Ile Ala Gln Lys Leu Gln Ser Val Ala Ile Asn Thr Leu Asp Asn Asn
340 345 350GCG ATC AAC AAC ACC ACC TAT AAT TTA AAC AAT TTG CAC AAC GCT TTG 1160Ala Ile Asn Asn Thr Thr Tyr Asn Leu Asn Asn Leu His Asn Ala Leu355 360 365 370AAT TTC CAA GCC TAT GAA AGC ACG ATA GAA CAA TAC AAT AAC GCT TTA 1208Asn Phe Gln Ala Tyr Glu Ser Thr Ile Glu Gln Tyr Asn Asn Ala Leu
375 380 385AAA CAA ATT TCT TGG ATC AGT TTT ACT GAG CCT AAA AAC TTA CTC AAA 1256Lys Gln Ile Ser Trp Ile Ser Phe Thr Glu Pro Lys Asn Leu Leu Lys
390 395 400AAC ACT TCC AAT AAC TAC CAA ATC GGC ACC GTT ACC AAC GCT CAA GGG 1304Asn Thr Ser Asn Asn Tyr Gln Ile Gly Thr Val Thr Asn Ala Gln Gly
405 410 415CAA AAT ATC AGC GCC TAT GAT TGC ATG ACT GCT ACC GGA AGC CTT TCT 1352Gln Asn Ile Ser Ala Tyr Asp Cys Met Thr Ala Thr Gly Ser Leu Ser
420 425 430AGC AAT GCT TCT AGC GGG ATT TCA TGC TCA GCC ACA AGC TCC ACA AGT 1400Ser Asn Ala Ser Ser Gly Ile Ser Cys Ser Ala Thr Ser Ser Thr Ser435 440 445 450TCC ACA AAT AGC TTT GAC AAT TCT TTA GTC GCT ACC TCC AAA GTC CAA 1448Ser Thr Asn Ser Phe Asp Asn Ser Leu Val Ala Thr Ser Lys Val Gln
455 460 465ACC ATC AAC GGC AAA GAG CAG ATC GGC GTG AAT TCT TTT AAC CTT GTC 1496Thr Ile Asn Gly Lys Glu Gln Ile Gly Val Asn Ser Phe Asn Leu Val
470 475 480TCT CAA GTG TGG AGC GTT TAT AAT TCT TTA AAA ACT TCA GAA GAA AAT 1544Ser Gln Val Trp Ser Val Tyr Asn Ser Leu Lys Thr Ser Glu Glu Asn
485 490 495TTG CAA AAA AAC GCC AAT ATT TTA TGC GCT AAT GGG ACG CAA TCT GGG 1592Leu Gln Lys Asn Ala Asn Ile Leu Cys Ala Asn Gly Thr Gln Ser Gly
500 505 510ACA AGC TCA TGC AAT AGC TCT TCA GGG GGT TTG AGC ATC AGC GGG AAC 1640Thr Ser Ser Cys Asn Ser Ser Ser Gly Gly Leu Ser Ile Ser Gly Asn515 520 525 530GCC CAA TTG CAA AAT ATT TTA AGC CCT ACT AGT GGG ACT ACC ACT AAT 1688Ala Gln Leu Gln Asn Ile Leu Ser Pro Thr Ser Gly Thr Thr Thr Asn
535 540 545ACT CAA GCT AAA AGC AAC GCT CCC AAA CTA AAA GCG ATG GTG GTG GTG 1736Thr Gln Ala Lys Ser Asn Ala Pro Lys Leu Lys Ala Met Val Val Val
550 555 560AAT AAT GAA GAA GAA GCT AAA ACG GCC AAT TTA GCC CAA AGC AGC GGG 1784Asn Asn Glu Glu Glu Ala Lys Thr Ala Asn Leu Ala Gln Ser Ser Gly
565 570 575ACA ACC ACA CAA TCT CCT AAC AGC ACG GTG ATG GGA GCT TTA AAC ACC 1832Thr Thr Thr Gln Ser Pro Asn Ser Thr Val Met Gly Ala Leu Asn Thr
580 585 590GTG TTG CAA AAT GTC AGC AAT TTC CAA CAA AGC ATT CAA AAC GCT TTT 1880Val Leu Gln Asn Val Ser Asn Phe Gln Gln Ser Ile Gln Asn Ala Phe595 600 605 610CAA AAC CAA GAA AGT AAT ATC CAA GCT TGG GCG AAT GCG ATT TAT AAC 1928
Gln Asn Gln Glu Ser Asn Ile Gln Ala Trp Ala Asn Ala Ile Tyr Asn
615 620 625ACT AAT GGG AGT CAG TCG CAA GAG ATG ACA CCT AAC AAT AAC CAA GAT 1976Thr Asn Gly Ser Gln Ser Gln Glu Met Thr Pro Asn Asn Asn Gln Asp
630635 640TTA CGC ATC CAA TTG AGG GCG AAT TTT TAC CAG CTC ATC AAT ACC ATT 2024Leu Arg Ile Gln Leu Arg Ala Asn Phe Tyr Gln Leu Ile Asn Thr Ile
645 650 655AAC CAG CAA GTG CCT ACA GAC ATG AAT GCT TTA ATT AAT CAA ACC CAA 2072Asn Gln Gln Val Pro Thr Asp Met Asn Ala Leu Ile Asn Gln Ser Gln
660 665 670CAA ACC CAA CAA ACA AGC GGA TCA GCA AGC AAT AAT AAC CCA TCC CCG 2120Gln Thr Gln Gln Thr Ser Gly Ser Ala Ser Asn Asn Asn Ala Cys Ala675 680 685 690AGT GGA ATG AGT GGG AGT AAT GGT AAC TGG TCC TAT CAG CAA TGG TCC 2168Ser Gly Met Ser Gly Ser Asn Gly Asn Trp Cys Tyr Gln Gln Trp Ser
695 700 705GAT TCT AAG GCT TAT TAC AGC GGG TTG CAA ACC GCT TTA GGG TAT CAA 2216Asp Ser Lys Ala Tyr Tyr Ser Gly Leu Gln Ser Ala Leu Gly Tyr Gln
710 715 720ACG CAA CCG ACA ACT CAA AGC GGG AGC AAT GGT GGG AAC AGC ATC ACC 2264Thr Gln Ala Thr Thr Gln Ser Gly Ser Asn Gly Gly Asn Ser Ile Thr
725 730 735TAC AAT GTC CAA CAA ATC ACG CTC ACT AGT AAT GGT TTG CTC AAC CAA 2312Tyr Asn Val Gln Gln Ile Thr Leu Thr Ser Asn Gly Leu Leu Asn Gln
740 745 750ATC ATC ACA AAT CTT AAG AGC GTT AAT GGA GGC AAT GGC GCG AGT GGT 2360Ile Ile Thr Asn Leu Lys Ser Val Asn Gly Gly Asn Gly Ala Ser Gly755 760 765 770ACA GGC AGT GGG AAT GGC ACC AGT CAA ATC AAC ACA GCC TAC CAG ATG 2408Thr Gly Ser Gly Asn Gly Thr Ser Gln Ile Asn Thr Ala Tyr Gln Met
775 780 785CTC ACA GAC GCC AGC GAT GGG AAA TTA GGG ACT TAT AGT AGT AGT AGT 2456Leu Thr Asp Ala Ser Asp Gly Lys Leu Gly Thr Tyr Ser Ser Ser Ser
790 795 800GGC AGT AAT AAC GGC TAT ACG CCA TGC AAT AGC ACC AAT GGG AGC AAT 2504Gly Ser Asn Asn Gly Tyr Thr Pro Cys Asn Ser Thr Asn Gly Ser Asn
805 810 815AAA ACG AGT GGG AAC AAT TGT TAT GAA CCC AAC AAA CAA CAA AAC GCC 2552Lys Thr Ser Gly Asn Asn Cys Tyr Glu Pro Asn Lys Gln Gln Asn Ala
820 825 830ACC ACC GCA ACC GCC ACA ACC GAC AGC AAT TTA CAA AAA GTC TAT AAT 2600Thr Thr Ala Thr Ala Thr Thr Asp Ser Asn Leu Gln Lys Val Tyr Asn835 840 845 850GAC GCC CAA AAA ATA GCC AAC ATT ATC GCC AGC TCT GGG AAC AAT AAA 2648Asp Ala Gln Lys Ile Ala Asn Ile Ile Ala Ser Ser Gly Asn Asn Lys
855 860 865GGC GTT GAA AAC GGC TTA AAA CAA TTC TTT GAA GCG TTA AAA AAT AAT 2696Gly Val Glu Asn Gly Leu Lys Gln Phe Phe Glu Ala Leu Lys Asn Asn
870 875 880AGC AGC AGT CTC AGT AAT TTA TGT GGT AAT GGT AGT AGC GGT AGT AGT 2744Ser Ser Ser Leu Ser Asn Leu Cys Gly Asn Gly Ser Ser Gly Ser Ser
885 890 895GGC ACT ACT TGC TCC GGT TGG CTT ATC AAC CTT TTA GGG GCA ATC CCC 2792Gly Thr Thr Cys Ser Gly Trp Leu Ile Asn Leu Leu Gly Ala Ile Pro
900 905 910ACC AAT GGA GTG AGC GAT ACG AAT AAT TTA ATT AAT CTG CTC ACT GAA 2840Thr Asn Gly Val Ser Asp Thr Asn Asn Leu Ile Asn Leu Leu Thr Glu915 920 925 930TTC ATT AAA ACC GCC GGG TTT ATC CAA AAT AAT GAT AGT AGT GTA TCT 2888Phe Ile Lys Thr Ala Gly Phe Ile Gln Asn Asn Asp Ser Ser Val Ser
935940 945ACT AGT CTT ACA AGC GCT TTT CAA GCC ATT ACG AGC GCT ATT TCT CAA 2936Thr Ser Leu Thr Ser Ala Phe Gln Ala Ile Thr Ser Ala Ile Ser Gln
950 955 960GGG TTT CAA GCC TTA CAA AAC GAT ATT AGC CCT AAT GCG ATT TTA ACC 2984Gly Phe Gln Ala Leu Gln Asn Asp Ile Ser Pro Asn Ala Ile Leu Thr
965 970 975 TTG CTC CAA GAG ATT ACT TCT AAC ACC ACC ACC ATT CAG TCA TTC TCG 3032 Leu Leu Gln Glu Ile Thr Ser Asn Thr Thr Thr Ile Gln Ser Phe Ser
980 985 990 CAA ACC TTA CGG CAG CTT TTA GGG GAT AAA ACA TTC TTT ATG GCG CAA 3080 Gln Thr Leu Arg Gln Leu Leu Gly Asp Lys Thr Phe Phe Met Ala Gln 995 1000 1005 1010 CAA AAG CTC ATT GAT GCG ATG ATT AAC GCC AGA AAT CAG GTT CAA AAC 3128 Gln Lys Leu Ile Asp Ala Met Ile Asn Ala Arg Asn Gln Val Gln Asn
1015 1020 1025 GCG CAA AAT CAA GCC AAT AAC TAC GGC TCT CAA CCC GTT TTA AGC CAG 3176 Ala Gln Asn Gln Ala Asn Asn Tyr Gly Ser Gln Pro Val Leu Ser Gln
1030 1035 1040 TAT GCG GCC GCT AAA AGC ACC CAA CAT GGC ATG AGC AAT GGT TTA GGG 3224 Tyr Ala Ala Ala Lys Ser Thr Gln His Gly Met Ser Asn Gly Leu Gly
1045 1050 1055 GTT GGT TTG GGC TAT AAA TAC TTC TTT GGT AAA GCG AGA AAA TTA GGC 3272 Val Gly Leu Gly Tyr Lys Tyr Phe Phe Gly Lys Ala Arg Lys Leu Gly
1060 1065 1070 CTT AGG CAT TAT TTT TTC TTT GAT TAC GGC TTT AGT GAA ATA GGC CTA 3320 Leu Arg His Tyr Phe Phe Phe Asp Tyr Gly Phe Ser Glu Ile Gly Leu1075 1080 1085 1090 GCC AAT CAA AGC GTG AAA GCG AAT ATC TTT GCT TAT GGGGTA GGC ACG 3368 Ala Asn Gln Ser Val Lys Ala Asn Ile Phe Ala Tyr Gly Val Gly Thr
1095 1100 1105 GAT TTT TTA TGG AAC TTA TTC AGG AGG ACT TAC AAC ACT AAA GCG TTG 3416 Asp Phe Leu Trp Asn Leu Phe Arg Arg Thr Tyr Asn Thr Lys Ala Leu
1110 1115 1120 AAT TTT GGG CTA TTT GCT GGG GTC CAA CTG GGC GGC GCA ACC TGG CTT 3464 Asn Phe Gly Leu Phe Ala Gly Val Gln Leu Gly Gly Ala Thr Trp Leu
1125 1130 1135 AGC TCC TTA AGG CAA CAA ATC ATT GAC AAC TGG GGG AGT GCT AAT GAC 3512Ser Ser Leu Arg Gln Gln Ile Ile Asp Asn Trp Gly Ser Ala Asn Asp
1140 1145 1150 ATC CAT TCA ACG AAT TTT CAA GTG GCG CTG AAT TTT GGG GTG CGC ACC 3560 Ile His Ser Thr Asn Phe Gln Val Ala Leu Asn Phe Gly Val Arg Thr1155 1160 1165 1170 AAC TTC GCG GAG TTT AAG CGT TTT GCT AAG AAA TTC CAC AAT CAA GGG 3608 Asn Phe Ala Glu Phe Lys Arg Phe Ala Lys Lys Phe His Asn Gln Gly
1175 1180 1185 GTC ATC AGC CAA AAG AGC GTG GAA TTT GGG ATC AAA GTG CCT CTC ATC 3656 Val Ile Ser Gln Lys Ser Val Glu Phe Gly Ile Lys Val Pro Leu Ile
1190 1195 1200 AAT CAA GCG TAT TTG AAT AGC GCT GGA GCT GAT GTG AGT TAC AGG AGG 3704 Asn Gln Ala Tyr Leu Asn Ser Ala Gly Ala Asp Val Ser Tyr Arg Arg
1205 1210 1215 CTT TAT ACT TTT TAT ATC AAT TAC ATC ATG GGG TTT TAAAAAAGGG TGTGTC 3756 Leu Tyr Thr Phe Tyr Ile Asn Tyr Ile Met Gly Phe
1220 1225 1230 ATGGAAATCT TACAATTCAT CGGCTATGGG AATATGG 3793
(2) Sequence 150 data:
(i) sequence characteristics:
(A) length: 1230 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 150: met Ile Lys Lys Ala Arg Lys Phe Ile Pro Phe Phe Leu Ile Gly Ser 151015 Leu Leu Ala Glu Asp Asn Gly Trp Tyr Met Ser Val Gly Tyr Gln Ile
20 25 30Gly Gly Thr Gln Gln Phe Ile Asn Asn Lys Gln Leu Leu Glu Asn Gln
35 40 45Asn Ile Ile Asn Ser Val Thr Gln Ser Ala Ile Asn Ile Ala Gly Pro
50 55 60Thr Thr Gly Leu Ile Thr Leu Ser Ser Gln Thr Val Ile Asp Ala Leu65 70 75 80Gly Tyr Gly Val Ser Asn Thr Val Gly Asn Gln Leu Glu Gly Ile Ser
85 90 95Asn Ile Leu Asn Gln Ile Gly Lys Arg Lys Asp Phe Tyr Ser Ser Arg
100 105 110Gln Ile Ser Ser Ile Ser Gln Gln Ile Ile Gly Leu Lys Gly Ser Ser
115 120 125Asp Pro Leu Lys Ala His Ser Ser Gln Ile Thr Ala Lys Leu Leu Ser
130 135 140Asn Thr Gln Ser Ala Phe Asp Gln Gly Ile Ala Leu Ser Thr Asn Ile145 150 155 160Ile Ser Ser Ile Asn Ser Leu Asn Pro Ser Asn Asn Thr Gln Glu Val
165170 175Lys Lys Gln Leu Gln Asn Thr Ala Gln Ser Met Thr Glu Leu Leu Gln
180 185 190Gln Ile Glu His Ser Ile Thr Lys Thr Thr Ser Thr Thr Tyr Ala Gln
195 200 205Ser Leu Leu Ser Asn Leu Thr Asp Ala Val Asn Ala Ser Ser Asn Asn
210 215 220Thr Ala Tyr Val Ser Ala Leu Val Asn Ala Leu Asn Thr Leu Gly Val225 230 235 240Gly Val Phe Pro Thr Thr Thr Thr Thr His Val Val Leu Asn Pro Pro
245 250 255Gly Gln Val Val Phe Tyr Pro Thr Asn Ser Ile Leu Gly Ser Thr Ser
260 265 270Ser Asn Ser Asn Asn Gln Gln Gln Tyr Asn Asn Thr Leu Leu Met Asn
275 280 285Thr Leu Gln Gly Thr Leu Ser Ala Asn Thr Gln Asn Asn Pro Asn Gly
290 295 300Cys Ala Asn Gln Val Gln Cys Leu Glu Gln Phe Ile Gln Asn Leu Ala305 310 315 320Pro Leu Ala Ala Thr Pro Thr Ser Asn Asn Gln Ala Asn Gln Gln Val
325 330 335Gln Ala Ile Ala Gln Lys Leu Gln Ser Val Ala Ile Asn Thr Leu Asp
340 345 350Asn Asn Ala Ile Asn Asn Thr Thr Tyr Asn Leu Asn Asn Leu His Asn
355 360 365Ala Leu Asn Phe Gln Ala Tyr Glu Ser Thr Ile Glu Gln Tyr Asn Asn
370 375 380Ala Leu Lys Gln Ile Ser Trp Ile Ser Phe Thr Glu Pro Lys Asn Leu385 390 395 400Leu Lys Asn Thr Ser Asn Asn Tyr Gln Ile Gly Thr Val Thr Asn Ala
405 410 415Gln Gly Gln Asn Ile Ser Ala Tyr Asp Cys Met Thr Ala Thr Gly Ser
420 425 430Leu Ser Ser Asn Ala Ser Ser Gly Ile Ser Cys Ser Ala Thr Ser Ser
435 440 445Thr Ser Ser Thr Asn Ser Phe Asp Asn Ser Leu Val Ala Thr Ser Lys
450 455 460Val Gln Thr Ile Asn Gly Lys Glu Gln Ile Gly Val Asn Ser Phe Asn465 470 475 480Leu Val Ser Gln Val Trp Ser Val Tyr Asn Ser Leu Lys Thr Ser Glu
485 490 495Glu Asn Leu Gln Lys Asn Ala Asn Ile Leu Cys Ala Asn Gly Thr Gln
500 505 510Ser Gly Thr Ser Ser Cys Asn Ser Ser Ser Gly Gly Leu Ser Ile Ser
515 520 525Gly Asn Ala Gln Leu Gln Asn Ile Leu Ser Pro Thr Ser Gly Thr Thr
530 535 540Thr Asn Thr Gln Ala Lys Ser Asn Ala Pro Lys Leu Lys Ala Met Val545 550 555 560Val Val Asn Asn Glu Glu Glu Ala Lys Thr Ala Asn Leu Ala Gln Ser
565 570 575Ser Gly Thr Thr Thr Gln Ser Pro Asn Ser Thr Val Met Gly Ala Leu
580 585 590Asn Thr Val Leu Gln Asn Val Ser Asn Phe Gln Gln Ser Ile Gln Asn
595 600 605Ala Phe Gln Asn Gln Glu Ser Asn Ile Gln Ala Trp Ala Asn Ala Ile
610 615 620Tyr Asn Thr AsnGly Ser Gln Ser Gln Glu Met Thr Pro Asn Asn Asn625 630 635 640Gln Asp Leu Arg Ile Gln Leu Arg Ala Asn Phe Tyr Gln Leu Ile Asn
645 650 655Thr Ile Asn Gln Gln Val Pro Thr Asp Met Asn Ala Leu Ile Asn Gln
660 665 670Ser Gln Gln Thr Gln Gln Thr Ser Gly Ser Ala Ser Asn Asn Asn Ala
675 680 685Cys Ala Ser Gly Met Ser Gly Ser Asn Gly Asn Trp Cys Tyr Gln Gln
690 695 700Trp Ser Asp Ser Lys Ala Tyr Tyr Ser Gly Leu Gln Ser Ala Leu Gly705 710 715 720Tyr Gln Thr Gln Ala Thr Thr Gln Ser Gly Ser Asn Gly Gly Asn Ser
725 730 735Ile Thr Tyr Asn Val Gln Gln Ile Thr Leu Thr Ser Asn Gly Leu Leu
740 745 750Asn Gln Ile Ile Thr Asn Leu Lys Ser Val Asn Gly Gly Asn Gly Ala
755 760 765Ser Gly Thr Gly Ser Gly Asn Gly Thr Ser Gln Ile Asn Thr Ala Tyr
770 775 780Gln Met Leu Thr Asp Ala Ser Asp Gly Lys Leu Gly Thr Tyr Ser Ser785 790 795 800Ser Ser Gly Ser Asn Asn Gly Tyr Thr Pro Cys Asn Ser Thr Asn Gly
805 810 815Ser Asn Lys Thr Ser Gly Asn Asn Cys Tyr Glu Pro Asn Lys Gln Gln
820 825 830Asn Ala Thr Thr Ala Thr Ala Thr Thr Asp Ser Asn Leu Gln Lys Val
835 840 845Tyr Asn Asp Ala Gln Lys IleAla Asn Ile Ile Ala Ser Ser Gly Asn
850 855 860Asn Lys Gly Val Glu Asn Gly Leu Lys Gln Phe Phe Glu Ala Leu Lys865 870 875 880Asn Asn Ser Ser Ser Leu Ser Asn Leu Cys Gly Asn Gly Ser Ser Gly
885 890 895Ser Ser Gly Thr Thr Cys Ser Gly Trp Leu Ile Asn Leu Leu Gly Ala
900 905 910Ile Pro Thr Asn Gly Val Ser Asp Thr Asn Asn Leu Ile Asn Leu Leu
915 920 925Thr Glu Phe Ile Lys Thr Ala Gly Phe Ile Gln Asn Asn Asp Ser Ser
930 935 940Val Ser Thr Ser Leu Thr Ser Ala Phe Gln Ala Ile Thr Ser Ala Ile945 950 955 960Ser Gln Gly Phe Gln Ala Leu Gln Asn Asp Ile Ser Pro Asn Ala Ile
965 970 975Leu Thr Leu Leu Gln Glu Ile Thr Ser Asn Thr Thr Thr Ile Gln Ser
980 985 990Phe Ser Gln Thr Leu Arg Gln Leu Leu Gly Asp Lys Thr Phe Phe Met
995 1000 1005Ala Gln Gln Lys Leu Ile Asp Ala Met Ile Asn Ala Arg Asn Gln Val 1010 1015 1020Gln Asn Ala Gln Asn Gln Ala Asn Asn Tyr Gly Ser Gln Pro Val Leu025 1030 1035 1040Ser Gln Tyr Ala Ala Ala Lys Ser Thr Gln His Gly Met Ser Asn Gly
1045 1050 1055Leu Gly Val Gly Leu Gly Tyr Lys Tyr Phe Phe Gly Lys Ala Arg Lys
1060 1065 1070Leu Gly Leu Arg His Tyr Phe Phe Phe Asp Tyr Gly Phe Ser Glu Ile
1075 1080 1085Gly Leu Ala Asn Gln Ser Val Lys Ala Asn Ile Phe Ala Tyr Gly Val 1090 1095 1100Gly Thr Asp Phe Leu Trp Asn Leu Phe Arg Arg Thr Tyr Asn Thr Lys105 1110 1115 1120Ala Leu Asn Phe Gly Leu Phe Ala Gly Val Gln Leu GIy Gly Ala Thr
1125 1130 1135Trp Leu Ser Ser Leu Arg Gln Gln Ile Ile Asp Asn Trp Gly Ser Ala
1140 1145 1150Asn Asp Ile His Ser Thr Asn Phe Gln Val Ala Leu Asn Phe Gly Val
1155 1160 1165Arg Thr Asn Phe Ala Glu Phe Lys Arg Phe Ala Lys Lys Phe His Asn 1170 1175 1180Gln Gly Val Ile Ser Gln Lys Ser Val Glu Phe Gly Ile Lys Val Pro185 1190 1195 1200Leu Ile Asn Gln Ala Tyr Leu Asn Ser Ala Gly Ala Asp Val Ser Tyr
1205 1210 1215Arg Arg Leu Tyr Thr Phe Tyr Ile Asn Tyr Ile Met Gly Phe
1220 1225 1230
(2) Sequence 151 data:
(i) sequence characteristics:
(A) length: 1259bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 48...1226
(D) Other information:
(xi) Description of the sequence: sequence 151: TAAGGATAAA ATCAAGCGAT TAGCCCGAAT TTTAAGAGAG TATTAAG ATG AAT AAA 56
Met Asn Lys
1AAA GCG TAT TTT GGG GAG TTT GGA GGG AGT TTT GTT TCG GAG TTG TTA 104Lys Ala Tyr Phe Gly Glu Phe Gly Gly Ser Phe Val Ser Glu Leu Leu
5 10 15GTG CCT GCA TTA AGA GAA TTA GAA CAG GCG TTT GAT GCG TGT TTG AAA 152Val Pro Ala Leu Arg Glu Leu Glu Gln Ala Phe Asp Ala Cys Leu Lys20 25 30 35GAT GAA AAA TTC CAA AAA GAA TAT TTT CGT CTT TTA AAG GAT TTT GTG 200Asp Glu Lys Phe Gln Lys Glu Tyr Phe Arg Leu Leu Lys Asp Phe Val
40 45 50GGC CGT CCT AGC CCT TTA ACC TTG TGT CAA AAT ATC GTT TCT AAC CCT 248Gly Arg Pro Ser Pro Leu Thr Leu Cys Gln Asn Ile Val Ser Asn Pro
55 60 65AAA GTC AAG CTT TAT TTA AAA CGA GAG GAT TTA ATC CAT GGC GGG GCG 296Lys Val Lys Leu Tyr Leu Lys Arg Glu Asp Leu Ile His Gly Gly Ala
70 75 80CAT AAG ACT AAT CAA GCC TTA GGG CAA GCC CTT TTA GCG AAA AAA ATG 344His Lys Thr Asn Gln Ala Leu Gly Gln Ala Leu Leu Ala Lys Lys Met
85 90 95GGT AAA ACA AGG ATC ATC GCT GAA ACA GGC GCC GGT CAG CAT GGC GTG 392Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val100 105 110 115GCG ACG GCT ATC GCT TGC GCA TTA TTG AAC TTA AAA TGC GTG GTT TTT 440Ala Thr Ala Ile Ala Cys Ala Leu Leu Asn Leu Lys Cys Val Val Phe
120 125 130ATG GGA TCT AAA GAC ATC AAG CGC CAG GAA ATG AAT GTT TTT AGA ATG 488Met Gly Ser Lys Asp Ile Lys Arg Gln Glu Met Asn Val Phe Arg Met
135 140 145CAC TTA TTA GGC GCT GAA GTG AGA GAG GTT AAT TCA GGG AGC GCG ACG 536His Leu Leu Gly Ala Glu Val Arg Glu Val Asn Ser Gly Ser Ala Thr
150 155 160CTT AAA GAC GCT GTG AAT GAA GCC TTA AGA GAT TGG GCG AGC AGT TAC 584Leu Lys Asp Ala Val Asn Glu Ala Leu Arg Asp Trp Ala Ser Ser Tyr
165 170 175AAG GAC ACG CAT TAT TTG CTA GGC ACA GCC GCC GGG CCA CAC CCT TAC 632Lys Asp Thr His Tyr Leu Leu Gly Thr Ala Ala Gly Pro His Pro Tyr180 185 190 195CCC ACA ATG GTT AAA ACC TTT CAA AAA ATG ATA GGC GAT GAG GTT AAA 680Pro Thr Met Val Lys Thr Phe Gln Lys Met Ile Gly Asp Glu Val Lys
200 205 210AGC CAG ATT TTA GAA AAA GAA AAC CGC TTG CCT GAT TAT GTG ATC GCA 728Ser Gln Ile Leu Glu Lys Glu Asn Arg Leu Pro Asp Tyr Val Ile Ala
215 220 225TGC GTT GGA GGG GGG TCT AAC GCT ATA GGG ATA TTC AGC GCA TTT TTA 776Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Ile Phe Ser Ala Phe Leu
230 235 240AAC GAC AAA GAA GTT AAA CTC ATA GGC GTA GAG CCG GCG GGT TTA GGG 824Asn Asp Lys Glu Val Lys Leu Ile Gly Val Glu Pro Ala Gly Leu Gly
245 250 255CTA GAA ACC AAT AAG CAT GGG GCG ACT TTG AAT AAG GGG CGT GTG GGG 872Leu Glu Thr Asn Lys His Gly Ala Thr Leu Asn Lys Gly Arg Val Gly260 265 270 275ATT TTG CAT GGG AAT AAA ACC TAT CTT TTA CAA GAT GAT GAA GGC CAG 920Ile Leu His Gly Asn Lys Thr Tyr Leu Leu Gln Asp Asp Glu Gly Gln
280 285 290ATT GCA GAA AGC CAT AGC ATT AGC GCC GGG CTT GAT TAT CCA GGA GTG 968Ile Ala Glu Ser His Ser Ile Ser Ala Gly Leu Asp Tyr Pro Gly Val
295 300 305GGG CCA GAA CAC AGC TAT TTA AAA GAA AGT GGG CGT GCG GTT TAT GAA 1016Gly Pro Glu His Ser Tyr Leu Lys Glu Ser Gly Arg Ala Val Tyr Glu
310 315 320AGC GCA AGC GAT GCT GAA GCG CTA GAA GCC TTC AAG TTG TTG TGC CAA 1064Ser Ala Ser Asp Ala Glu Ala Leu Glu Ala Phe Lys Leu Leu Cys Gln
325 330 335AAA GAA GGC ATT ATC CCA GCG CTA GAA AGC TCA CAC GCC TTA GCG TAT 1112Lys Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr340 345 350 355GCC TTA AAG CTC GCT CAA AAA TGC GAA GAA GAA AGC ATC ATC GTA GTG 1160Ala Leu Lys Leu Ala Gln Lys Cys Glu Glu Glu Ser Ile Ile Val Val
360 365 370AAT TTA AGC GGC AGA GGG GAT AAG GAT TTA AGC ACC GTT TAT AAC GCT 1208Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Ser Thr Val Tyr Asn Ala
375 380 385TTA AAA GGA GGT TTA AAA TGAGGTATCA AAACATGTTT GAAACCTTAA AAA 1259Leu Lys Gly Gly Leu Lys
390
(2) Sequence 152 data:
(i) sequence characteristics:
(A) length: 393 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 152: met Asn Lys Lys Ala Tyr Phe Gly Glu Phe Gly Gly Ser Phe Val Ser 151015 Glu Leu Leu Val Pro Ala Leu Arg Glu Leu Glu Gln Ala Phe Asp Ala
20 25 30Cys Leu Lys Asp Glu Lys Phe Gln Lys Glu Tyr Phe Arg Leu Leu Lys
35 40 45Asp Phe Val Gly Arg Pro Ser Pro Leu Thr Leu Cys Gln Asn Ile Val
50 55 60Ser Asn Pro Lys Val Lys Leu Tyr Leu Lys Arg Glu Asp Leu Ile His65 70 75 80Gly Gly Ala His Lys Thr Asn Gln Ala Leu Gly Gln Ala Leu Leu Ala
85 90 95Lys Lys Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln
100 105 110His Gly Val Ala Thr Ala Ile Ala Cys Ala Leu Leu Asn Leu Lys Cys
115 120 125Val Val Phe Met Gly Ser Lys Asp Ile Lys Arg Gln Glu Met Asn Val
130 135 140Phe Arg Met His Leu Leu Gly Ala Glu Val Arg Glu Val Asn Ser Gly145 150 155 160Ser Ala Thr Leu Lys Asp Ala Val Asn Glu Ala Leu Arg Asp Trp Ala
165 170 175Ser Ser Tyr Lys Asp Thr His Tyr Leu Leu Gly Thr Ala Ala Gly Pro
180 185 190His Pro Tyr Pro Thr Met Val Lys Thr Phe Gln Lys Met Ile Gly Asp
195 200 205Glu Val Lys Ser Gln Ile Leu Glu Lys Glu Asn Arg Leu Pro Asp Tyr
210 215 220Val Ile Ala Cys Val Gly Gly GlySer Asn Ala Ile Gly Ile Phe Ser225 230 235 240Ala Phe Leu Asn Asp Lys Glu Val Lys Leu Ile Gly Val Glu Pro Ala
245 250 255Gly Leu Gly Leu Glu Thr Asn Lys His Gly Ala Thr Leu Asn Lys Gly
260 265 270Arg Val Gly Ile Leu His Gly Asn Lys Thr Tyr Leu Leu Gln Asp Asp
275 280 285Glu Gly Gln Ile Ala Glu Ser His Ser Ile Ser Ala Gly Leu Asp Tyr
290 295 300Pro Gly Val Gly Pro Glu His Ser Tyr Leu Lys Glu Ser Gly Arg Ala305 310 315 320Val Tyr Glu Ser Ala Ser Asp Ala Glu Ala Leu Glu Ala Phe Lys Leu
325 330 335Leu Cys Gln Lys Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala
340 345 350Leu Ala Tyr Ala Leu Lys Leu Ala Gln Lys Cys Glu Glu Glu Ser Ile
355 360 365Ile Val Val Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Ser Thr Val
370 375 380Tyr Asn Ala Leu Lys Gly Gly Leu Lys385 390
(2) Sequence 153 data:
(i) sequence characteristics:
(A) length: 601bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 197...547
(D) Other information:
(xi) Description of the sequence: sequence 153: TGGTGATGCA AAACCAAAAC AAGCGCATCA TGAATTACAT TCCTATTAAG TTGAATTTAA 60GTGGGGTGAT CCCCCCTATT TTCGCTTCAG CTTTGCTCGT GTTCCCTTCT ACGATTTTGC 120AGCAAGCCAC AAGCAACAAA ACCTTGCAAG CGGTTGCGNA TTTTTTAAGC CCGCAAGGTA 180TGCGTATAAT ATTTTG ATG TTC TTG CTC ATC ATC TTT TTT GCT TAC TTT TAT 232
Met Phe Leu Leu Ile Ile Phe Phe Ala Tyr Phe Tyr
1 5 10TCT TCT ATT GTG TTC AAT TCT AAG GAT ATT GCG GAT AAT TTG AGG CGT 280Ser Ser Ile Val Phe Asn Ser Lys Asp Ile Ala Asp Asn Leu Arg Arg
15 20 25AAT GGC GGG TAT ATT CCA GGG CTT AGG CCT GGA GAG GGG ACT TCA TCG 328Asn Gly Gly Tyr Ile Pro Gly Leu Arg Pro Gly Glu Gly Thr Ser Ser
30 35 40TTT TTA AAT TCT GTA GCG AGT AAG CTC ACT TTG TGG GGT TCA TTG TAT 376Phe Leu Asn Ser Val Ala Ser Lys Leu Thr Leu Trp Gly Ser Leu Tyr45 50 55 60TTA GCG CTC ATT TCT ACC GTG CCT TGG ATT TTG GTT AAG GCT ATG GGC 424Leu Ala Leu Ile Ser Thr Val Pro Trp Ile Leu Val Lys Ala Met Gly
65 70 75GTG CCT TTT TAC TTT GGA GGC ACA GCG GTG CTG ATT GTG GTT CAA GTC 472Val Pro Phe Tyr Phe Gly Gly Thr Ala Val Leu Ile Val Val Gln Val
80 85 90GCT ATT GAC ACC ATG AAA AAG ATT GAA GCG CAA ATT TAT ATG AGC AAG 520Ala Ile Asp Thr Met Lys Lys Ile Glu Ala Gln Ile Tyr Met Ser Lys
95 100 105TAT AAA ACT TTA AGC GCG GTA GGC TTT TAATGGCAAT CTCTATTAAA AGCCCAA 574Tyr Lys Thr Leu Ser Ala Val Gly Phe
110 115AAGAAATCAA AGCTCTAAGA AAAGCCG 601
(2) Sequence 154 data:
(i) sequence characteristics:
(A) length: 117 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 154: met Phe Leu Leu Ile Ile Phe Phe Ala Tyr Phe Tyr Ser Ser Ile Val 151015 Phe Asn Ser Lys Asp Ile Ala Asp Asn Leu Arg Arg Asn Gly Gly Tyr
20 25 30lle Pro Gly Leu Arg Pro Gly Glu Gly Thr Ser Ser Phe Leu Asn Ser
35 40 45Val Ala Ser Lys Leu Thr Leu Trp Gly Ser Leu Tyr Leu Ala Leu Ile
50 55 60Ser Thr Val Pro Trp Ile Leu Val Lys Ala Met Gly Val Pro Phe Tyr65 70 75 80Phe Gly Gly Thr Ala Val Leu Ile Val Val Gln Val Ala Ile Asp Thr
85 90 95Met Lys Lys Ile Glu Ala Gln Ile Tyr Met Ser Lys Tyr Lys Thr Leu
100 105 110Ser Ala Val Gly Phe
115
(2) Sequence 155 data:
(i) sequence characteristics:
(A) length: 725bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 64...675
(D) Other information:
(xi) Description of the sequence: sequence 155: GAAAACAGGA TAACGCATGA AACATGTGAG TAGGGATTTT GATACCGGTT GGGTTGCGTA 60TCA ATG ACT CTA GGC ATT GAT GAA GCG GGT AGG GGG TGT TTG GCC GGT 108
Met Thr Leu Gly Ile Asp Glu Ala Gly Arg Gly Cys Leu Ala Gly
1 5 10 15TCG CTT TTT GTG GCT GGG GTG GCG TGT AAT GAA AAA ACA GCC TTA GAA 156Ser Leu Phe Val Ala Gly Val Ala Cys Asn Glu Lys Thr Ala Leu Glu
20 25 30TTT CTA AAA ATG GGT TTA AAA GAC AGC AAG AAG CTC AGC CTA AAA AAG 204Phe Leu Lys Met Gly Leu Lys Asp Ser Lys Lys Leu Ser Leu Lys Lys
35 40 45CGC TTT TTC TTA GAA TAT AAG ATC AAA ACG CAT GGT GAG GTG GGG TTT 252Arg Phe Phe Leu Glu Tyr Lys Ile Lys Thr His Gly Glu Val Gly Phe
50 55 60TTC GTG GTT AAA AAA AGC GCA AAT GAA ATT GAT AGC TTG GGC TTA GGG 300Phe Val Val Lys Lys Ser Ala Asn Glu Ile Asp Ser Leu Gly Leu Gly
65 70 75GCG TGT TTG AAA CTC GCT GTG CAA GAA ATT TTA GAA AAT GGT TGC TCT 348Ala Cys Leu Lys Leu Ala Val Gln Glu Ile Leu Glu Asn Gly Cys Ser80 85 90 95TTA GTT GAT GAA ATA AAA ATA GAC GGC AAC ACG GCG TTT GGC TTG AAC 396Leu Val Asp Glu Ile Lys Ile Asp Gly Asn Thr Ala Phe Gly LeuAsn
100 105 110AAA CGC TAC CCC CAT ATA CAA ACC ATC ATC AAG GGC GAT GAA ACA ATC 444Lys Arg Tyr Pro His Ile Gln Thr Ile Ile Lys Gly Asp Glu Thr Ile
115 120 125GCT CAA ATC GCT ATG GCG TCT GTT TTG GCG AAA GCT TTT AAG GAC AGA 492Ala Gln Ile Ala Met Ala Ser Val Leu Ala Lys Ala Phe Lys Asp Arg
130 135 140GAA ATG CTA GAG TTG CAC GCT TTG TTT AAG GAA TAC GGC TGG GAT AAG 540Glu Met Leu Glu Leu His Ala Leu Phe Lys Glu Tyr Gly Trp Asp Lys
145 150 155AAT TGC GGG TAT GGG ACT AAA CAA CAT ATA GAA GCG ATC ATT AAG CTA 588Asn Cys Gly Tyr Gly Thr Lys Gln His Ile Glu Ala Ile Ile Lys Leu160 165 170 175GGG GCT ACG CCT TTT CAT CGG CAT AGC TTC ACG CTT AAA AAC CGC ATC 636Gly Ala Thr Pro Phe His Arg His Ser Phe Thr Leu Lys Asn Arg Ile
180 185 190TTA AAT CCC AAA CTC TTA GAG GTG GAA CAA CGC CTT ATT TAAAAGGGCG CT 687Leu Asn Pro Lys Leu Leu Glu Val Glu Gln Arg Leu Ile
195 200GAGATGGGTA GCGCTCGCTG AAGAAAGGTC GATGCGTT 725
(2) Sequence 156 data:
(i) sequence characteristics:
(A) length: 204 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 156: met Thr Leu Gly Ile Asp Glu Ala Gly Arg Gly Cys Leu Ala Gly Ser 151015 Leu Phe Val Ala Gly Val Ala Cys Asn Glu Lys Thr Ala Leu Glu Phe
20 25 30Leu Lys Met Gly Leu Lys Asp Ser Lys Lys Leu Ser Leu Lys Lys Arg
35 40 45Phe Phe Leu Glu Tyr Lys Ile Lys Thr His Gly Glu Val Gly Phe Phe
50 55 60Val Val Lys Lys Ser Ala Asn Glu Ile Asp Ser Leu Gly Leu Gly Ala65 70 75 80Cys Leu Lys Leu Ala Val GlnGlu Ile Leu Glu Asn Gly Cys Ser Leu
85 90 95Val Asp Glu Ile Lys Ile Asp Gly Asn Thr Ala Phe Gly Leu Asn Lys
100 105 110Arg Tyr Pro His Ile Gln Thr Ile Ile Lys Gly Asp Glu Thr Ile Ala
115 120 125Gln Ile Ala Met Ala Ser Val Leu Ala Lys Ala Phe Lys Asp Arg Glu
130 135 140Met Leu Glu Leu His Ala Leu Phe Lys Glu Tyr Gly Trp Asp Lys Asn145 150 155 160Cys Gly Tyr Gly Thr Lys Gln His Ile Glu Ala Ile Ile Lys Leu Gly
165 170 175Ala Thr Pro Phe His Arg His Ser Phe Thr Leu Lys Asn Arg Ile Leu
180 185 190Asn Pro Lys Leu Leu Glu Val Glu Gln Arg Leu Ile
195 200
(2) Sequence 157 data:
(i) sequence characteristics:
(A) length: 2821bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 58...2769
(D) Other information:
(xi) Description of the sequence: sequence 157: GATTAATCAG TGGAAGAATA CAAAGACACC CTAAACTTAA ACACAACCAC CTTTTCT ATG 60
Met
1AAG GGG AAT TTG AGC GTT AAT GAG CCT AAA ACT TAC GCC AAA TGG CAA 108Lys Gly Asn Leu Ser Val Asn Glu Pro Lys Thr Tyr Ala Lys Trp Gln
5 10 15GAG CAA CAA GCG TTT AAA CGC ATG CAA GCT AGG AAA GAC AAC CAT GGG 156Glu Gln Gln Ala Phe Lys Arg Met Gln Ala Arg Lys Asp Asn His Gly
20 25 30GAT TTC ACT TTG CAT GAC GGG CCG CCT TAT GCG AAC GGG CAT TTG CAT 204Asp Phe Thr Leu His Asp Gly Pro Pro Tyr Ala Asn Gly His Leu His
35 40 45TTG GGG CAT GCC TTA AAT AAA ATT TTA AAA GAC ATT GTC GTT AAA AGA 252Leu Gly His Ala Leu Asn Lys Ile Leu Lys Asp Ile Val Val Lys Arg50 55 60 65GAA TAT TTT AAG GGG AAG AAA ATC TAT TAC ACG CCC GGT TGG GAT TGC 300Glu Tyr Phe Lys Gly Lys Lys Ile Tyr Tyr Thr Pro Gly Trp Asp Cys
70 75 80CAT GGT TTG CCC ATT GAG CAG CAA ATT TTA GAG CGA TTA GAA AAA GAA 348His Gly Leu Pro Ile Glu Gln Gln Ile Leu Glu Arg Leu Glu Lys Glu
8590 95AAA ACA AGC CTA GAA AAC CCC ACG CTG TTT AGA GAA AAG TGC CGA GAT 396Lys Thr Ser Leu Glu Asn Pro Thr Leu Phe Arg Glu Lys Cys Arg Asp
100 105 110CAT GCG AAG AAA TTT TTA GAA ATC CAA AAG AAT GAA TTT TTG CAA TTG 444His Ala Lys Lys Phe Leu Glu Ile Gln Lys Asn Glu Phe Leu Gln Leu
115 120 125GGT GTT TTG GGG GAT TTT GAA GAT CCT TAT AAA ACC ATG GAT TTT AAA 492Gly Gal Leu Gly Asp Phe Glu Asp Pro Tyr Lys Thr Met Asp Phe Lys130 135 140 145TTT GAA GCG AGC ATT TAT AGA GCC TTA GTG GAA GTG GCT AAA AAA GGG 540Phe Glu Ala Ser Ile Tyr Arg Ala Leu Val Glu Val Ala Lys Lys Gly
150 155 160CTT TTG AAA GAG CGC CAC AAG CCT ATT TAT TGG AGT TAT GCA TGC GAG 588Leu Leu Lys Glu Arg His Lys Pro Ile Tyr Trp Ser Tyr Ala Cys Glu
165 170 175AGC GCT TTA GCG GAA GCT GAA GTG GAA TAC AAA ATG AAA AAA TCG CCC 636Ser Ala Leu Ala Glu Ala Glu Val Glu Tyr Lys Met Lys Lys Ser Pro
180 185 190TCC ATT TTC GTG GCG TTT GGT TTG AAA AAG GAG AGT TTA GAA AAA TTA 684Ser Ile Phe Val Ala Phe Gly Leu Lys Lys Glu Ser Leu Glu Lys Leu
195 200 205AAA GTC AAA AAA GCG AGC TTG GTG ATT TGG ACG ACC ACG CCT TGG ACT 732Lys Val Lys Lys Ala Ser Leu Val Ile Trp Thr Thr Thr Pro Trp Thr210 215 220 225TTG TAT GCG AAT GTA GCG ATC GCT TTG AAA AAA GAC GCT GTT TAT GCG 780Leu Tyr Ala Asn Val Ala Ile Ala Leu Lys Lys Asp Ala Val Tyr Ala
230 235 240CTC ACC CAA AAA GGC TAT TTA GTC GCT AAA GCC TTG CAT GAA AAA TTA 828Leu Thr Gln Lys Gly Tyr Leu Val Ala Lys Ala Leu His Glu Lys Leu
245 250 255GCC GCT TTA GGG GTG GTG GAT AAT GAG ATC ACA CAT GAA TTC AAT TCC 876Ala Ala Leu Gly Val Val Asp Asn Glu Ile Thr His Glu Phe Asn Ser
260 265 270AAT GAT TTA GAA TAT TTA GTG GCT ACA AAC CCG CTC AAT CAA AGG GAT 924Asn Asp Leu Glu Tyr Leu Val Ala Thr Asn Pro Leu Asn Gln Arg Asp
275 280 285TCG CTG GTG GCT TTA GGA GAG CAT GTC GGT TTA GAA GAT GGC ACA GGA 972Ser Leu Val Ala Leu Gly Glu His Val Gly Leu Glu Asp Gly Thr Gly290 295 300 305GCC GTG CAT ACC GCA CCT GGG CAT GGT GAA GAG GAC TAT TAT TTA GGC 1020Ala Val His Thr Ala Pro Gly His Gly Glu Glu Asp Tyr Tyr Leu Gly
310 315 320TTA AGA TAT AAT TTA GAA GTG TTA ATG TCT GTA GAT GAG AAA GGT TGC 1068Leu Arg Tyr Asn Leu Glu Val Leu Met Ser Val Asp Glu Lys Gly Cys
325 330 335TAT GAT GAG GGC ATT ATC CAT AAC CAA CTA TTA GAT GAA AGC TAT CTG 1116Tyr Asp Glu Gly Ile Ile His Asn Gln Leu Leu Asp Glu Ser Tyr Leu
340 345 350GGC GAG CAT GTT TTT AAG GCT CAA AAA CGC ATT ATA GAG CAA TTG GGC 1164Gly Glu His Val Phe Lys Ala Gln Lys Arg Ile Ile Glu Gln Leu Gly
355 360 365GAT TCT TTA TTG CTA GAG CAA GAG ATT GAG CAT TCT TAT CCG CAT TGC 1212Asp Ser Leu Leu Leu Glu Gln Glu Ile Glu His Ser Tyr Pro His Cys370 375 380 385TGG AGG ACG CAC AAG CCT GTG ATT TAC AGA GCG ACT ACG CAA TGG TTT 1260Trp Arg Thr His Lys Pro Val Ile Tyr Arg Ala Thr Thr Gln Trp Phe
390 395400ATT TTA ATG GAT GAG CCT TTT ATC CAA AAT GAT GGC TCT CAA AAA ACC 1308Ile Leu Met Asp Glu Pro Phe Ile Gln Asn Asp Gly Ser Gln Lys Thr
405 410 415TTA AGA GAA GTG GCT TTA GAT GCG ATT GAA AAG GTG GAA TTT GTG CCA 1356Leu Arg Glu Val Ala Leu Asp Ala Ile Glu Lys Val Glu Phe Val Pro
420 425 430AGC AGC GGG AAA AAC CGC CTA AAA ACC ATG ATA GAA AAC CGC CCT GAT 1404Ser Ser Gly Lys Asn Arg Leu Lys Thr Met Ile Glu Asn Arg Pro Asp
435 440 445TGG TGC TTG AGC CGG CAA AGA AAA TGG GGC GTG CCA CTG GCC TTT TTC 1452Trp Cys Leu Ser Arg Gln Arg Lys Trp Gly Val Pro Leu Ala Phe Phe450 455 460 465ATA GAC AAA CGC ACG AAT AAG CCT TGT TTT GAA AGC GAA GTT TTA GAG 1500Ile Asp Lys Arg Thr Asn Lys Pro Cys Phe Glu Ser Glu Val Leu Glu
470 475 480CAT GTG GCC AAT CTT TTT GAG AAA AAA GGC TGT GAT GTG TGG TGG GAG 1548His Val Ala Asn Leu Phe Glu Lys Lys Gly Cys Asp Val Trp Trp Glu
485 490 495TAT AGC GTG AAA GAT TTA TTG CCC CTT AGC TAT CAA GAG GAC GCC AAG 1596Tyr Ser Val Lys Asp Leu Leu Pro Pro Ser Tyr Gln Glu Asp Ala Lys
500 505 510CAT TAT GAG AAA ATC ATG CAC ATT TTA GAC GTG TGG TTT GAT AGT GGT 1644His Tyr Glu Lys Ile Met His Ile Leu Asp Val Trp Phe Asp Ser Gly
515 520 525AGC ACC TTT AAG GCG GTT TTA GAA GAC TAT CAT GGA GAA AAA GGG CAA 1692Ser Thr Phe Lys Ala Val Leu Glu Asp Tyr His Gly Glu Lys Gly Gln530 535 540 545AGC CCT AGC GAT GTG ATC TTA GAA GGG AGC GAT CAG CAT AGG GGG TGG 1740Ser Pro Ser Asp Val IleLeu Glu Gly Ser Asp Gln His Arg Gly Trp
550 555 560TTT CAA AGC TCG CTT CTA ATC GGT TGT GTT TTA AAC AAC CAA GCC CCT 1788Phe Gln Ser Ser Leu Leu Ile Gly Cys Val Leu Asn Asn Gln Ala Pro
565 570 575TTT AAA AAG GTC ATT ACG CAT GGC TTT ATC GTA GAT GAA AAG GGC GAA 1836Phe Lys Lys Val Ile Thr His Gly Phe Ile Val Asp Glu Lys Gly Glu
580 585 590AAA ATG AGT AAA TCT AAG GGC AAT GTG GTG TCT TTG GAC AAG CTG CTC 1884Lys Met Ser Lys Ser Lys Gly Asn Val Val Ser Leu Asp Lys Leu Leu
595 600 605AAA ACG CAT GGG AGC GAT GTG GTG CGT TTG TGG GTA GCG TTT AAT GAC 1932Lys Thr His Gly Ser Asp Val Val Arg Leu Trp Val Ala Phe Asn Asp610 615 620 625TAT CAA AAC GAT TTG AGA GTC TCT CAA ACC TTT TTC ACT CAA ACA GAA 1980Tyr Gln Asn Asp Leu Arg Val Ser Gln Thr Phe Phe Thr Gln Thr Glu
630 635 640CAA CAT TAT AAA AAA TTC CGC AAC ACC CTG AAA TTC TTA CTC GCT AAT 2028Gln His Tyr Lys Lys Phe Arg Asn Thr Leu Lys Phe Leu Leu Ala Asn
645 650 655TTT AGC GAT ATG GAT CTC AAG AAT TTA GAA CGC CCC CAT AAC TTC AGC 2076Phe Ser Asp Met Asp Leu Lys Asn Leu Glu Arg Pro His Asn Phe Ser
660 665 670CCT TTA GAT CAT TTT ATG TTA GAG ACT TTA GAA ACC ATA AGC GCT GGA 2124Pro Leu Asp His Phe Met Leu Glu Thr Leu Glu Thr Ile Ser Ala Gly
675 680 685GTC AAT AGC GCG TTT GAA GAG CAT GAT TTT GTG AAA GGC TTG AAT ATT 2172Val Asn Ser Ala Phe Glu Glu His Asp Phe Val Lys Gly Leu Asn Ile690 695700 705TTA ATG GCG TTT GTT ACC AAT GAA TTG AGC GGG ATT TAT TTA GAC GCT 2220Leu Met Ala Phe Val Thr Asn Glu Leu Ser Gly Ile Tyr Leu Asp Ala
710 715 720TGC AAG GAT AGC TTG TAT TGC GAT AGC AAA AAC AAT GAA AAA CGC CAA 2268Cys Lys Asp Ser Leu Tyr Cys Asp Ser Lys Asn Asn Glu Lys Arg Gln
725 730 735GCC ATT CAA ATG GTT TTA CTC GCT ACA GCT AGT AAG TTG TGC TAC TTT 2316Ala Ile Gln Met Val Leu Leu Ala Thr Ala Ser Lys Leu Cys Tyr Phe
740 745 750TTA GCC CCG ATT TTA ACG CAC ACG ATT GAA GAA GTT TTA GAG CAT AGC 2364Leu Ala Pro Ile Leu Thr His Thr Ile Glu Glu Val Leu Glu His Ser
755 760 765CAA GCG CTT CGC ATT TTT TTA CAA GCC AAA GAT GTG TTT GAT TTA AAA 2412Gln Ala Leu Arg Ile Phe Leu Gln Ala Lys Asp Val Phe Asp Leu Lys770 775 780 785GAC ATT AGC GTT TCA GAA AAA CTC CAC CTC AAA GAG TTT AAA AAA CCA 2460Asp Ile Ser Val Ser Glu Lys Leu His Leu Lys Glu Phe Lys Lys Pro
790 795 800GAA AAT TTT GAA GCC GTT TTA GCC TTG CGT TCT GCC TTT AAT GAA GAG 2508Glu Asn Phe Glu Ala Val Leu Ala Leu Arg Ser Ala Phe Asn Glu Glu
805 810 815TTA GAC CGA TTG AAA AAA GAA GGC GTC ATT AAA AAT TCG TTA GAG TGC 2556Leu Asp Arg Leu Lys Lys Glu Gly Val Ile Lys Asn Ser Leu Glu Cys
820 825 830GCT ATT GAA GTA AAA GAA AAA GCG TTG GAT GAA AAT TTA GTA GAA GAG 2604Ala Ile Glu Val Lys Glu Lys Ala Leu Asp Glu Asn Leu Val Glu Glu
835 840 845TTG CTG ATG GTA AGC TTT GTG GGG ATT GCA AAA GAA AAA TTG AGT GAA 2652Leu Leu Met Val Ser Phe Val Gly Ile Ala Lys Glu Lys Leu Ser Glu850 855 860 865ACG CCA GCA TTC ACG CTC TTT AAA GCC CCC TTT TAT AAA TGC CCC AGG 2700Thr Pro Ala Phe Thr Leu Phe Lys Ala Pro Phe Tyr Lys Cys Pro Arg
870 875 880TGT TGG CGT TTT AAA AGC GAG CTA GAA AAC ACC CCT TGC AAG CGT TGC 2748Cys Trp Arg Phe Lys Ser Glu Leu Glu Asn Thr Pro Cys Lys Arg Cys
885 890 895GAA CAG GTT TTA AAA GAG CGA TGATAAAAGG ATAGGGCTTT TGAAAACTTT ACAA 2803Glu Gln Val Leu Lys Glu Arg
900ACCCATAGAG TTTTACAA 2821
(2) Sequence 158 data:
(i) sequence characteristics:
(A) length: 904 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 158: met Lys Gly Asn Leu Ser Val Asn Glu Pro Lys Thr Tyr Ala Lys Trp 151015 Gln Glu Gln Gln Ala Phe Lys Arg Met Gln Ala Arg Lys Asp Asn His
20 25 30Gly Asp Phe Thr Leu His Asp Gly Pro Pro Tyr Ala Asn Gly His Leu
35 40 45His Leu Gly His Ala Leu Asn Lys Ile Leu Lys Asp Ile Val Val Lys
50 55 60Arg Glu Tyr Phe Lys Gly Lys Lys Ile Tyr Tyr Thr Pro Gly Trp Asp65 70 7580Cys His Gly Leu Pro Ile Glu Gln Gln Ile Leu Glu Arg Leu Glu Lys
85 90 95Glu Lys Thr Ser Leu Glu Asn Pro Thr Leu Phe Arg Glu Lys Cys Arg
100 105 110Asp His Ala Lys Lys Phe Leu Glu Ile Gln Lys Asn Glu Phe Leu Gln
115 120 125Leu Gly Val Leu Gly Asp Phe Glu Asp Pro Tyr Lys Thr Met Asp Phe
130 135 140Lys Phe Glu Ala Ser Ile Tyr Arg Ala Leu Val Glu Val Ala Lys Lys145 150 155 160Gly Leu Leu Lys Glu Arg His Lys Pro Ile Tyr Trp Ser Tyr Ala Cys
165 170 175Glu Ser Ala Leu Ala Glu Ala Glu Val Glu Tyr Lys Met Lys Lys Ser
180 185 190Pro Ser Ile Phe Val Ala Phe Gly Leu Lys Lys Glu Ser Leu Glu Lys
195 200 205Leu Lys Val Lys Lys Ala Ser Leu Val Ile Trp Thr Thr Thr Pro Trp
210 215 220Thr Leu Tyr Ala Asn Val Ala Ile Ala Leu Lys Lys Asp Ala Val Tyr225 230 235 240Ala Leu Thr Gln Lys Gly Tyr Leu Val Ala Lys Ala Leu His Glu Lys
245 250 255Leu Ala Ala Leu Gly Val Val Asp Asn Glu Ile Thr His Glu Phe Asn
260 265 270Ser Asn Asp Leu Glu Tyr Leu Val Ala Thr Asn Pro Leu Asn Gln Arg
275 280 285Asp Ser Leu Val Ala Leu Gly Glu His Val Gly Leu Glu Asp Gly Thr
290 295300Gly Ala Val His Thr Ala Pro Gly His Gly Glu Glu Asp Tyr Tyr Leu305 310 315 320Gly Leu Arg Tyr Asn Leu Glu Val Leu Met Ser Val Asp Glu Lys Gly
325 330 335Cys Tyr Asp Glu Gly Ile Ile His Asn Gln Leu Leu Asp Glu Ser Tyr
340 345 350Leu Gly Glu His Val Phe Lys Ala Gln Lys Arg Ile Ile Glu Gln Leu
355 360 365Gly Asp Ser Leu Leu Leu Glu Gln Glu Ile Glu His Ser Tyr Pro His
370 375 380Cys Trp Arg Thr His Lys Pro Val Ile Tyr Arg Ala Thr Thr Gln Trp385 390 395 400Phe Ile Leu Met Asp Glu Pro Phe Ile Gln Asn Asp Gly Ser Gln Lys
405 410 415Thr Leu Arg Glu Val Ala Leu Asp Ala Ile Glu Lys Val Glu Phe Val
420 425 430Pro Ser Ser Gly Lys Asn Arg Leu Lys Thr Met Ile Glu Asn Arg Pro
435 440 445Asp Trp Cys Leu Ser Arg Gln Arg Lys Trp Gly Val Pro Leu Ala Phe
450 455 460Phe Ile Asp Lys Arg Thr Asn Lys Pro Cys Phe Glu Ser Glu Val Leu465 470 475 480Glu His Val Ala Asn Leu Phe Glu Lys Lys Gly Cys Asp Val Trp Trp
485 490 495Glu Tyr Ser Val Lys Asp Leu Leu Pro Pro Ser Tyr Gln Glu Asp Ala
500 505 510Lys His Tyr Glu Lys Ile Met His Ile Leu Asp Val Trp Phe Asp Ser
515 520 525Gly Ser Thr Phe Lys Ala Val Leu Glu Asp Tyr His Gly Glu Lys Gly
530 535 540Gln Ser Pro Ser Asp Val Ile Leu Glu Gly Ser Asp Gln His Arg Gly545 550 555 560Trp Phe Gln Ser Ser Leu Leu Ile Gly Cys Val Leu Asn Asn Gln Ala
565 570 575Pro Phe Lys Lys Val Ile Thr His Gly Phe Ile Val Asp Glu Lys Gly
580 585 590Glu Lys Met Ser Lys Ser Lys Gly Asn Val Val Ser Leu Asp Lys Leu
595 600 605Leu Lys Thr His Gly Ser Asp Val Val Arg Leu Trp Val Ala Phe Asn
610 615 620Asp Tyr Gln Asn Asp Leu Arg Val Ser Gln Thr Phe Phe Thr Gln Thr625 630 635 640Glu Gln His Tyr Lys Lys Phe Arg Asn Thr Leu Lys Phe Leu Leu Ala
645 650 655Asn Phe Ser Asp Met Asp Leu Lys Asn Leu Glu Arg Pro His Asn Phe
660 665 670Ser Pro Leu Asp His Phe Met Leu Glu Thr Leu Glu Thr Ile Ser Ala
675 680 685Gly Val Asn Ser Ala Phe Glu Glu His Asp Phe Val Lys Gly Leu Asn
690 695 700Ile Leu Met Ala Phe Val Thr Asn Glu Leu Ser Gly Ile Tyr Leu Asp705 710 715 720Ala Cys Lys Asp Ser Leu Tyr Cys Asp Ser Lys Asn Asn Glu Lys Arg
725 730 735Gln Ala Ile Gln Met Val Leu Leu Ala Thr Ala Ser Lys Leu Cys Tyr
740 745 750Phe Leu Ala Pro Ile Leu Thr His Thr Ile Glu Glu Val Leu Glu His
755 760 765Ser Gln Ala Leu Arg Ile Phe Leu Gln Ala Lys Asp Val Phe Asp Leu
770 775 780Lys Asp Ile Ser Val Ser Glu Lys Leu His Leu Lys Glu Phe Lys Lys785 790 795 800Pro Glu Asn Phe Glu Ala Val Leu Ala Leu Arg Ser Ala Phe Asn Glu
805 810 815Glu Leu Asp Arg Leu Lys Lys Glu Gly Val Ile Lys Asn Ser Leu Glu
820 825 830Cys Ala Ile Glu Val Lys Glu Lys Ala Leu Asp Glu Asn Leu Val Glu
835 840 845Glu Leu Leu Met Val Ser Phe Val Gly Ile Ala Lys Glu Lys Leu Ser
850 855 860Glu Thr Pro Ala Phe Thr Leu Phe Lys Ala Pro Phe Tyr Lys Cys Pro865 870 875 880Arg Cys Trp Arg Phe Lys Ser Glu Leu Glu Asn Thr Pro Cys Lys Arg
885 890 895Cys Glu Gln Val Leu Lys Glu Arg
900
(2) Sequence 159 data:
(i) sequence characteristics:
(A) length: 339bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...288
(D) Other information:
(xi) Description of the sequence: sequence 159: TGTAGAATGA AATCCTAGCC AGTGAGCTAG AATTTAAATT TTTAATCAAA GGAGTCATCA 60TGGCACACC ATG AAG AAC AAC ACG GCG GGC ACC ACC ACC ACC ATC ACC ACA 111
Met Lys Asn Asn Thr Ala Gly Thr Thr Thr Thr Ile Thr Thr
1 5 10CAC ACC ACC ACC ACT ATC ATG GCG GTG AAC ACC ACC ATC ACC ACC ACA 159His Thr Thr Thr Thr Ile Met Ala Val Asn Thr Thr Ile Thr Thr Thr15 20 25 30GCT CTC ATC ATG AAG AAG GTT GTT GCA GCA CTA GCG ACA GTC ATC ATC 207Ala Leu Ile Met Lys Lys Val Val Ala Ala Leu Ala Thr Val Ile Ile
35 40 45AAG AAG AAG GTT GCT GCC ACG GGC ATC ACG AGT AAT ATC GGT GTG GCT 255Lys Lys Lys Val Ala Ala Thr Gly Ile Thr Ser Asn Ile Gly Val Ala
50 55 60AGG GGC AAC TTG ACT AGG GTT GTC TCT GGC TTT TGACTTTAAA ATACAATCAT 308Arg Gly Asn Leu Thr Arg Val Val Ser Gly Phe
65 70TCCATTCTAA CCCATTCTGA TCAAACCCGT T 339
(2) Sequence 160 data:
(i) sequence characteristics:
(A) length: 73 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 160: met Lys Asn Asn Thr Ala Gly Thr Thr Thr Thr Ile Thr Thr His Thr 151015 Thr Thr Thr Ile Met Ala Val Asn Thr Thr Ile Thr Thr Thr Ala Leu
20 25 30Ile Met Lys Lys Val Val Ala Ala Leu Ala Thr Val Ile Ile Lys Lys
35 40 45Lys Val Ala Ala Thr Gly Ile Thr Ser Asn Ile Gly Val Ala Arg Gly
50 55 60Asn Leu Thr Arg Val Val Ser Gly Phe65 70
(2) Sequence 161 data:
(i) sequence characteristics:
(A) length: 787bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...734
(D) Other information:
(xi) Description of the sequence: sequence 161: GTTTTCTACT TATGATTTTG TGGAAGAATA TTGCAAATTA AAGGAAATGC ATG CTT 56
Met Leu
1GAA AAA GTG TTT CAA GAA ATT ACC AAT AAA AGA AAG TTT TTT GCA AGT 104Glu Lys Val Phe Gln Glu Ile Thr Asn Lys Arg Lys Phe Phe Ala Ser
5 10 15TCT AGC ACA GGG GAG CAG TTT GAA AAC CAA TTT AGG AAT GAA TTA AAA 152Ser Ser Thr Gly Glu Gln Phe Glu Asn Gln Phe Arg Asn Glu Leu Lys
20 25 30AAA CAC TTT AGC GAA ATC AAT GGC GAT TTA ACA GAA GAA TTA AGC CAT 200Lys His Phe Ser Glu Ile Asn Gly Asp Leu Thr Glu Glu Leu Ser His35 4045 50ATT GAA GAA AAG CCT AAT AAA GAA ATC AAA ACC ACT TTT AAC CAA CTC 248Ile Glu Glu Lys Pro Asn Lys Glu Ile Lys Thr Thr Phe Asn Gln Leu
55 60 65AAA AAG CAA GTT TTA GAA AAA AAT CAC CCG CAC ACC CTT AAA AAC CCT 296Lys Lys Gln Val Leu Glu Lys Asn His Pro His Thr Leu Lys Asn Pro
70 75 80TTT TCA AAC CTT ACA AGC CAT TTT TTA TAC CAG CCT TTT GGC TCA CAA 344Phe Ser Asn Leu Thr Ser His Phe Leu Tyr Gln Pro Phe Gly Ser Gln
85 90 95AAT TAG CCT GAT TTT TTG GTT TTT ATT TTT GAC TAT GTG GTG GGG ATT 392Asn Tyr Pro Asp Phe Leu Val Phe Ile Phe Asp Tyr Val Val Gly Ile
100 105 110GAA ATC AAG TTT TCT AAA AAC GAT AAG GGT GAA AAA AAT CTT CAA ACA 440Glu Ile Lys Phe Ser Lys Asn Asp Lys Gly Glu Lys Asn Leu Gln Thr115 120 125 130TCT CGC CCC ATG TGG AAT TCA AAC CTG CCT AAA CCC AAT GCG ATT TAT 488Ser Arg Pro Met Trp Asn Ser Asn Leu Pro Lys Pro Asn Ala Ile Tyr
135 140 145GTG TAT GGA GTC GCT AAT GCA AAC ATC ACT TTT TTT AAA GGC TCA GAT 536Val Tyr Gly Val Ala Asn Ala Asn Ile Thr Phe Phe Lys Gly Ser Asp
150 155 160ATT TTG AGT TAT GAA ACC AGA GAG GTC TTG CTC AAG TAT TTT GAT ATT 584Ile Leu Ser Tyr Glu Thr Arg Glu Val Leu Leu Lys Tyr Phe Asp Ile
165 170 175TTA GAT AAA GAT GAA AGA AGT TTG AAA AAC GCC TTA AAG GAT TTA GAA 632Leu Asp Lys Asp Glu Arg Ser Leu Lys Asn Ala Leu Lys Asp Leu Glu
180 185 190AAC CCT TTT GGG TTT GCC CCC TAC ATC AGA AAA GCT TAT GAG CAT AAA 680Asn Pro Phe Gly Phe Ala Pro Tyr Ile Arg Lys Ala Tyr Glu His Lys195 200 205 210AGG AAT TTT CTA ACC ACC ACC AGA TTG AAA GCT TCT TTT CGC CCA ACC 728Arg Asn Phe Leu Thr Thr Thr Arg Leu Lys Ala Ser Phe Arg Pro Thr
215 220 225ACA TTT TAAGAGAGCG GAATGTCTTG GAATTTTTGA AAACGCTCAC TCATTAGCGT AT 786Thr PheT 787
(2) Sequence 162 data:
(i) sequence characteristics:
(A) length: 228 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 162: met Leu Glu Lys Val Phe Gln Glu Ile Thr Asn Lys Arg Lys Phe Phe 151015 Ala Ser Ser Ser Thr Gly Glu Gln Phe Glu Asn Gln Phe Arg Asn Glu
20 25 30Leu Lys Lys His Phe Ser Glu Ile Asn Gly Asp Leu Thr Glu Glu Leu
35 40 45Ser His Ile Glu Glu Lys Pro Asn Lys Glu Ile Lys Thr Thr Phe Asn
50 55 60Gln Leu Lys Lys Gln Val Leu Glu Lys Asn His Pro His Thr Leu Lys65 70 75 80Asn Pro Phe Ser Asn Leu Thr Ser His Phe Leu Tyr Gln Pro Phe Gly
85 90 95Ser Gln Asn Tyr Pro Asp Phe Leu Val Phe Ile Phe Asp Tyr Val Val
100 105 110Gly Ile Glu Ile Lys Phe Ser Lys Asn Asp Lys Gly Glu Lys Asn Leu
115 120 125Gln Thr Ser Arg Pro Met Trp Asn Ser Asn Leu Pro Lys Pro Asn Ala
130 135 140Ile Tyr Val Tyr Gly Val Ala Asn Ala Asn Ile Thr Phe Phe Lys Gly145 150 155 160Ser Asp Ile Leu Ser Tyr Glu Thr Arg Glu Val Leu Leu Lys Tyr Phe
165 170 175Asp Ile Leu Asp Lys Asp Glu Arg Ser Leu Lys Asn Ala Leu Lys Asp
180 185 190Leu Glu Asn Pro Phe Gly Phe Ala Pro Tyr Ile Arg Lys Ala Tyr Glu
195 200 205His Lys Arg Asn Phe Leu Thr Thr Thr Arg Leu Lys Ala Ser Phe Arg
210 215 220Pro Thr Thr Phe225
(2) Sequence 163 data:
(i) sequence characteristics:
(A) length: 540bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 53...493
(D) Other information:
(xi) Description of the sequence: sequence 163: CCAAACCCTT TTGAAACACT TGCTCACTAA CCCATTATAA GCCGCAAAAA CC ATG CTC 58
Met Leu
1TCT TTA AAA CAA GAT TCC TTT TTT TTC TTA TGT TTA GGA ATC CTG GGG 106Ser Leu Lys Gln Asp Ser Phe Phe Phe Leu Cys Leu Gly Ile Leu Gly
5 10 15TTT TAT TTT TAT AGC CTT TTG AGG GAT TTA ATG CCT TTT TTA CCC CCA 154Phe Tyr Phe Tyr Ser Leu Leu Arg Asp Leu Met Pro Phe Leu Pro Pro
20 25 30ATG ATT GGG TTT TTA TTC TTG TTT TAT GCG AAA AAA TAC GAT CAT TTT 202Met Ile Gly Phe Leu Phe Leu Phe Tyr Ala Lys Lys Tyr Asp His Phe35 40 45 50TTA CCC AGT TTG AGC GTG TTT GGT TGT TTG TTT TGG TTT GAG AGC ATG 250Leu Pro Ser Leu Ser Val Phe Gly Cys Leu Phe Trp Phe Glu Ser Met
55 60 65CAT TTA AAG ACT TTA GGC GTT TTA GCT TTA TTG TTT TTA ATC TAC CAT 298His Leu Lys Thr Leu Gly Val Leu Ala Leu Leu Phe Leu Ile Tyr His
70 75 80CAA ATC GCC TAT AAA AAC TCT TTA AAG CTT TTT AAT GAC GGC TTT TTA 346Gln Ile Ala Tyr Lys Asn Ser Leu Lys Leu Phe Asn Asp Gly Phe Leu
85 90 95TTC AAA ACT TTG CAT GTT TTT TTG GTT TAT TAC CTT TAT TTA TCG CGC 394Phe Lys Thr Leu His Val Phe Leu Val Tyr Tyr Leu Tyr Leu Ser Arg
100 105 110TTT TTT TCG ATG TCT TTG AGT TTG AAA ATA CTC GGC TTT CTC GCT CTT 442Phe Phe Ser Met Ser Leu Ser Leu Lys Ile Leu Gly Phe Leu Ala Leu115 120 125 130TTT GCT TTA ATA GAA AGC GCT TTG TGG GGT TTG TAT GAA AAA TCT TCG 490Phe Ala Leu Ile Glu Ser Ala Leu Trp Gly Leu Tyr Glu Lys Ser Ser
135 140 145CTA TAAGCTTTTG CTCTTTGTTT TTATAGGGTT TTGGGGGTTA CTAGCCT 540Leu
(2) Sequence 164 data:
(i) sequence characteristics:
(A) length: 147 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 164: met Leu Ser Leu Lys Gln Asp Ser Phe Phe Phe Leu Cys Leu Gly Ile 151015 Leu Gly Phe Tyr Phe Tyr Ser Leu Leu Arg Asp Leu Met Pro Phe Leu
20 25 30Pro Pro Met Ile Gly Phe Leu Phe Leu Phe Tyr Ala Lys Lys Tyr Asp
35 40 45His Phe Leu Pro Ser Leu Ser Val Phe Gly Cys Leu Phe Trp Phe Glu
50 55 60Ser Met His Leu Lys Thr Leu Gly Val Leu Ala Leu Leu Phe Leu Ile65 70 75 80Tyr His Gln Ile Ala Tyr Lys Asn Ser Leu Lys Leu Phe Asn Asp Gly
85 90 95Phe Leu Phe Lys Thr Leu His Val Phe Leu Val Tyr Tyr Leu Tyr Leu
100 105 110Ser Arg Phe Phe Ser Met Ser Leu Ser Leu Lys Ile Leu Gly Phe Leu
115 120 125Ala Leu Phe Ala Leu Ile Glu Ser Ala Leu Trp Gly Leu Tyr Glu Lys
130 135 140Ser Ser Leu145
(2) Sequence 165 data:
(i) sequence characteristics:
(A) length: 1888bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1835
(D) Other information:
(xi) Description of the sequence: sequence 165: CACTAAAGTC AATCCAAGCG CAAGTTGGAT GAAAAAATAA GAAGGAAGTT ATG AAA 56
Met Lys
1AAG TCA TTC AAA AAA TTA GGC TTT GTC TCT TTA GCG GCT AGT GGC GTG 104Lys Ser Phe Lys Lys Leu Gly Phe Val Ser Leu Ala Ala Ser Gly Val
5 10 15CTT TTA GGG AGC ATG AAC GCT ACC GAT TTA GAA ACC TAC GCA GCA TTG 152Leu Leu Gly Ser Met Asn Ala Thr Asp Leu Glu Thr Tyr Ala Ala Leu
20 25 30CAA AAA TCA TCG CAT GTT TTT GGT AAT TAT GCT GAA AAG GAT AAG GAT 200Gln Lys Ser Ser His Val Phe Gly Asn Tyr Ala Glu Lys Asp Lys Asp35 40 45 50AGT AAA TTA ACA AGC GAT TCA CCA ACG CAA CAA CAA GAT CAA AAA GTA 248Ser Lys Leu Thr Ser Asp Ser Pro Thr Gln Gln Gln Asp Gln Lys Val
55 60 65GCC CAA AAC ACC GCT TCA AAC GAC AGC CAA GAA GCG ACA ACA CTT GAA 296Ala Gln Asn Thr Ala Ser Asn Asp Ser Gln Glu Ala Thr Thr Leu Glu
70 75 80AAC ACC GCT TCT ACT GAC AAC ACA ACC GCC ACA ACT GAT GAA ACT TAT 344Asn Thr Ala Ser Thr Asp Asn Thr Thr Ala Thr Thr Asp Glu Thr Tyr
85 90 95ACA AAA AGC ACT GAC ACT ACT GTA GCT GGT GCG GCT CAA AAA GTA GAA 392Thr Lys Ser Thr Asp Thr Thr Val Ala Gly Ala Ala Gln Lys Val Glu
100 105 110ACC GAT AAC ACA GCC GTT CAA AGC GCT GAA CAA ACT TTA AAA ACA GAT 440Thr Asp Asn Thr Ala Val Gln Ser Ala Glu Gln Thr Leu Lys Thr Asp115 120 125 130GTA GCT AAA GTT CAA GCT GAT GCT AGT GCT AAA GAT TTT GAT GAA ACC 488Val Ala Lys Val Gln Ala Asp Ala Ser Ala Lys Asp Phe Asp Glu Thr
135 140 145 ACT TTT CAA GCC GAT CAA GCA GCA GAG CAA ACC GCT GAA AAA GCT TTA 536Thr Phe Gln Ala Asp Gln Ala Ala Glu Gln Thr Ala Glu Lys Ala Leu
150 155 160CAA CAG GCT GAG AGC AAA CTC AAC ACC GAT CAA CAG ACT TTA AAC ACA 584Gln Gln Ala Glu Ser Lys Leu Asn Thr Asp Gln Gln Thr Leu Asn Thr
165 170 175GCG TTA CAA GAT CAG ACG AAA ACA CCA ACC CCA TCA ACC CCA CCA ACT 632Ala Leu Gln Asp Gln Thr Lys Thr Pro Thr Pro Ser Thr Pro Pro Thr
180 185 190AAA GAG GAA CCA AAA CAC ACC GCT TCA AGC GGC ACA CCA CCA GCT CCA 680Lys Glu Glu Pro Lys His Thr Ala Ser Ser Gly Thr Pro Pro Ala Pro195 200 205 210GAA AGC CCA CCA GCT AAA AAA GAT GAA ACA AGT GGC ACA CCA AGT GCT 728Glu Ser Pro Pro Ala Lys Lys Asp Glu Thr Ser Gly Thr Pro Ser Ala
215 220 225AGT GGG AGT TCT GTG GCA AGC CAG CTA ACC AAA GAT ACC ACT ATG GTT 776Ser Gly Ser Ser Val Ala Ser Gln Leu Thr Lys Asp Thr Thr Met Val
230 235 240AAT AAT CTT AAG AGT GTG AGC GTG AGC GCG ATG AAC ACC ACT TTA AGT 824Asn Asn Leu Lys Ser Val Ser Val Ser Ala Met Asn Thr Thr Leu Ser
245 250 255GGA GTA GAA ACC ATG TCT CAA CAA ACT GCA ACG ATT GGC AAC CTT TTG 872Gly Val Glu Thr Met Ser Gln Gln Thr Ala Thr Ile Gly Asn Leu Leu
260 265 270AAT AGT AGC ACC GAT TTA AGC AGT GTG ATT CCC AAC GCT CAA GGG CTA 920Asn Ser Ser Thr Asp Leu Ser Ser Val Ile Pro Asn Ala Gln Gly Leu275 280 285 290AAC AGC GCG TTT AGC ACA TTA GAA AGC GCT CAA AAC ACT CTA AAA GGC 968Asn Ser Ala Phe Ser Thr Leu Glu Ser Ala Gln Asn Thr Leu Lys Gly
295 300 305TAT TTA AAT TCT TCT AGC GCG ACG ATT GGG CAA TTG ACA AAC GGA TCT 1016Tyr Leu Asn Ser Ser Ser Ala Thr Ile Gly Gln Leu Thr Asn Gly Ser
310 315 320AAT GCG GTT GTG GGC GCG TTA GAT AAA GCT ATC AAT CAA GTG GAT ATG 1064Asn Ala Val Val Gly Ala Leu Asp Lys Ala Ile Asn Gln Val Asp Met
325 330 335GCT TTG GCC GAT CTT AGT GCA GCT GAT ACG CAA AAA ACG CAA GCC GTT 1112Ala Leu Ala Asp Leu Ser Ala Ala Asp Thr Gln Lys Thr Gln Ala Val
340 345 350ACG CTT GCA ACT GCT AGT GAT AGT CCA ACG ACA ACG ACA GAT GCC ATC 1160Thr Leu Ala Thr Ala Ser Asp Ser Pro Thr Thr Thr Thr Asp Ala Ile355 360 365 370AAT TTC TTA AAC GCG CTA AAA AGC AAT CTA ATG GCT CAA AAA GAC GCT 1208Asn Phe Leu Asn Ala Leu Lys Ser Asn Leu Met Ala Gln Lys Asp Ala
375 380 385TTT TTG AAT GTG CAT AAA AAC ATT CAA ACC GCT GTC GCT CAA GCC CAG 1256Phe Leu Asn Val His Lys Asn Ile Gln Thr Ala Val Ala Gln Ala Gln
390 395 400GAA ACC TAC ACG CCA AGC GTG ATC AAC ACC AAT AAT TAC GGG CAA ATG 1304Glu Thr Tyr Thr Pro Ser Val Ile Asn Thr Asn Asn Tyr Gly Gln Met
405 410 415TAT GGG GTA GAT GCG ATG GCA GGG TAT AAG TGG TTC TTT GGC AAA ACC 1352Tyr Gly Val Asp Ala Met Ala Gly Tyr Lys Trp Phe Phe Gly Lys Thr
420 425 430AAA CGC TTT GGC TTT AGG TCT TAT GGA TAC TAC AGC TAT AAC CAT GCG 1400Lys Arg Phe Gly Phe Arg Ser Tyr Gly Tyr Tyr Ser Tyr Asn His Ala435 440 445 450AAT TTA AGC TTT GTG GGG AGC CAG CTT GGA ATC ATG GAG GGC GCG TCT 1448Asn Leu Ser Phe Val Gly Ser Gln Leu Gly Ile Met Glu Gly Ala Ser
455 460 465CAA GTG AAT AAC TTC ACT TAT GGC GTG GGC TTT GAT GTG CTC TAT AAC 1496Gln Val Asn Asn Phe Thr Tyr Gly Val Gly Phe Asp Val Leu Tyr Asn
470 475 480TTC TAT GAA AGC AAA GAG GGC TAT AAC ACA GCA GGG TTG TTC TTA GGC 1544Phe Tyr Glu Ser Lys Glu Gly Tyr Asn Thr Ala Gly Leu Phe Leu Gly
485 490 495TTT GGG TTA GGA GGG GAT TCG TTT ATC GTT CAA GGA GAG AGC TAC TTG 1592Phe Gly Leu Gly Gly Asp Ser Phe Ile Val Gln Gly Glu Ser Tyr Leu
500 505 510AAA TCT CAA ATG CAC ATT TGC AAC AAC ACC GCC GGC TGT TCA GCG AGC 1640Lys Ser Gln Met His Ile Cys Asn Asn Thr Ala Gly Cys Ser Ala Ser515 520 525 530ATG AAC ACA AGC TAC TTC CAA ATG CCT GTT GAA TTT GGT TTT AGG AGC 1688Met Asn Thr Ser Tyr Phe Gln Met Pro Val Glu Phe Gly Phe Arg Ser
535 540 545AAT TTC TCT AAACAC AGC GGG ATT GAA GTG GGC TTT AAA TTG CCT TTA 1736Asn Phe Ser Lys His Ser Gly Ile Glu Val Gly Phe Lys Leu Pro Leu
550 555 560TTC ACC AAC CAA TTC TAT AAA GAA AGG GGC GTA GAT GGA TCG GTA GAT 1784Phe Thr Asn Gln Phe Tyr Lys Glu Arg Gly Val Asp Gly Ser Val Asp
565 570 575GTG TTC TAT AAA AGG AAT TTC TCT ATT TAT TTT AAC TAC ATG ATC AAC 1832Val Phe Tyr Lys Arg Asn Phe Ser Ile Tyr Phe Asn Tyr Met Ile Asn
580 585 590TTC TAAGCCTTTC TATTCTTTCC AATAGAGGGT TTTCTCTCTG TTGGTTTCTT TTT 1888Phe595
(2) Sequence 166 data:
(i) sequence characteristics:
(A) length: 595 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 166: met Lys Lys Ser Phe Lys Lys Leu Gly Phe Val Ser Leu Ala Ala Ser 151015 Gly Val Leu Leu Gly Ser Met Asn Ala Thr Asp Leu Glu Thr Tyr Ala
20 25 30Ala Leu Gln Lys Ser Ser His Val Phe Gly Asn Tyr Ala Glu Lys Asp
35 40 45Lys Asp Ser Lys Leu Thr Ser Asp Ser Pro Thr Gln Gln Gln Asp Gln
50 55 60Lys Val Ala Gln Asn Thr Ala Ser Asn Asp Ser Gln Glu Ala Thr Thr65 70 75 80Leu Glu Asn Thr Ala Ser Thr Asp Asn Thr Thr Ala Thr Thr Asp Glu
8590 95Thr Tyr Thr Lys Ser Thr Asp Thr Thr Val Ala Gly Ala Ala Gln Lys
100 105 110Val Glu Thr Asp Asn Thr Ala Val Gln Ser Ala Glu Gln Thr Leu Lys
115 120 125Thr Asp Val Ala Lys Val Gln Ala Asp Ala Ser Ala Lys Asp Phe Asp
130 135 140Glu Thr Thr Phe Gln Ala Asp Gln Ala Ala Glu Gln Thr Ala Glu Lys145 150 155 160Ala Leu Gln Gln Ala Glu Ser Lys Leu Asn Thr Asp Gln Gln Thr Leu
165 170 175Asn Thr Ala Leu Gln Asp Gln Thr Lys Thr Pro Thr Pro Ser Thr Pro
180 185 190Pro Thr Lys Glu Glu Pro Lys His Thr Ala Ser Ser Gly Thr Pro Pro
195 200 205Ala Pro Glu Ser Pro Pro Ala Lys Lys Asp Glu Thr Ser Gly Thr Pro
210 215 220Ser Ala Ser Gly Ser Ser Val Ala Ser Gln Leu Thr Lys Asp Thr Thr225 230 235 240Met Val Asn Asn Leu Lys Ser Val Ser Val Ser Ala Met Asn Thr Thr
245 250 255Leu Ser Gly Val Glu Thr Met Ser Gln Gln Thr Ala Thr Ile Gly Asn
260 265 270Leu Leu Asn Ser Ser Thr Asp Leu Ser Ser Val Ile Pro Asn Ala Gln
275 280 285Gly Leu Asn Ser Ala Phe Ser Thr Leu Glu Ser Ala Gln Asn Thr Leu
290 295 300Lys Gly Tyr Leu Asn Ser Ser Ser Ala Thr Ile Gly Gln Leu Thr Asn305 310 315320Gly Ser Asn Ala Val Val Gly Ala Leu Asp Lys Ala Ile Asn Gln Val
325 330 335Asp Met Ala Leu Ala Asp Leu Ser Ala Ala Asp Thr Gln Lys Thr Gln
340 345 350Ala Val Thr Leu Ala Thr Ala Ser Asp Ser Pro Thr Thr Thr Thr Asp
355 360 365Ala Ile Asn Phe Leu Asn Ala Leu Lys Ser Asn Leu Met Ala Gln Lys
370 375 380Asp Ala Phe Leu Asn Val His Lys Asn Ile Gln Thr Ala Val Ala Gln385 390 395 400Ala Gln Glu Thr Tyr Thr Pro Ser Val Ile Asn Thr Asn Asn Tyr Gly
405 410 415Gln Met Tyr Gly Val Asp Ala Met Ala Gly Tyr Lys Trp Phe Phe Gly
420 425 430Lys Thr Lys Arg Phe Gly Phe Arg Ser Tyr Gly Tyr Tyr Ser Tyr Asn
435 440 445His Ala Asn Leu Ser Phe Val Gly Ser Gln Leu Gly Ile Met Glu Gly
450 455 460Ala Ser Gln Val Asn Asn Phe Thr Tyr Gly Val Gly Phe Asp Val Leu 465 470 475 480 Tyr Asn Phe Tyr Glu Ser Lys Glu Gly Tyr Asn Thr Ala Gly Leu Phe
485 490 495 Leu Gly Phe Gly Leu Gly Gly Asp Ser Phe Ile Val Gln Gly Glu Ser
500 505 510 Tyr Leu Lys Ser Gln Met His Ile Cys Asn Asn Thr Ala Gly Cys Ser
515 520 525 Ala Ser Met Asn Thr Ser Tyr Phe Gln Met Pro Val Glu Phe Gly Phe
530535 540 Arg Ser Asn Phe Ser Lys His Ser Gly Ile Glu Val Gly Phe Lys Leu 545 550 555 560 Pro Leu Phe Thr Asn Gln Phe Tyr Lys Glu Arg Gly Val Asp Gly Ser
565 570 575 Val Asp Val Phe Tyr Lys Arg Asn Phe Ser Ile Tyr Phe Asn Tyr Met
580 585 590 Ile Asn Phe
595
(2) Sequence 167 data:
(i) sequence characteristics:
(A) length: 1470bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 46...1416
(D) Other information:
(xi) Description of the sequence: sequence 167: TTTAAGAAAC TATTTGCGCA TTTGATGTTA AGGTTTCTCT AAAGC ATG CGT TAT TTT 57
Met Arg Tyr Phe
1CTT GTA GTT TTC TTG TTT TTG TTT GTG GGT TGC ACA AAA AAG GAT TTC 105Leu Val Val Phe Leu Phe Leu Phe Val Gly Cys Thr Lys Lys Asp Phe5 10 15 20ACG CTC AAA GAT TTA TCC TTG CCC CAA GAG GCT TCA AGG TAT CTT GCA 153Thr Leu Lys Asp Leu Ser Leu Pro Gln Glu Ala Ser Ser Tyr Leu Ala
25 30 35AGC TCT CAA AAT GGC AGT AAC AAC AAC CAA AGC ATT GAC CCC CAAGCG 201Ser Ser Gln Asn Gly Ser Asn Asn Asn Gln Ser Ile Asp Pro Gln Ala
40 45 50TTA AGA GAA AAT CTG AAA GAG AGC TAT CTC AAA GCG TGG TAT TCC CCA 249Leu Arg Glu Asn Leu Lys Glu Ser Tyr Leu Lys Ala Trp Tyr Ser Pro
55 60 65TGG CTA GAT ATG AAA GTC AAA AGC AAT AAA AAA GAA GTG TTT TGG ATC 297Trp Leu Asp Met Lys Val Lys Ser Asn Lys Lys Glu Val Phe Trp Ile
70 75 80CTT AAG GAG ATG AAT AAA TCC ACC GGT TAT GGC GAA GAT CTA AAA CCC 345Leu Lys Glu Met Asn Lys Ser Thr Gly Tyr Gly Glu Asp Leu Lys Pro85 90 95 100AAC GCA AAA GCT TTC AAT GAC GCA CTC ATT AAG AGC ATG GAT ATT GAG 393Asn Ala Lys Ala Phe Asn Asp Ala Leu Ile Lys Ser Met Asp Ile Glu
105 110 115CAT TAC CCT AGC GTT AAG ATT AGG GCT GTT GTA GCG CGA GAT AGC GAT 441His Tyr Pro Ser Val Lys Ile Arg Ala Val Val Ala Arg Asp Ser Asp
120 125 130GTG AGG GCT GTG CCT ACT AAC AAA CCT TAT TAT CTT TCT CAA AAA GGC 489Val Arg Ala Val Pro Thr Asn Lys Pro Tyr Tyr Leu Ser Gln Lys Gly
135 140 145TAT CCT TTT GAT AGG TAT CAA AAT TCG CTG ATT TTT CAA GGC ACG CCG 537Tyr Pro Phe Asp Arg Tyr Gln Asn Ser Leu Ile Phe Gln Gly Thr Pro
150 155 160GTT TTA ATC ACG CAT TTT AAT CTA GAT AAA ACT TAT GCC CAC ATT CAA 585Val Leu Ile Thr His Phe Asn Leu Asp Lys Thr Tyr Ala His Ile Gln165 170 175 180AGC AGT TTT GTT TAT GGC TGG ATC AAA GTT AGC GAT TTA GTC TAC ATG 633Ser Ser Phe Val Tyr Gly Trp Ile Lys Val Ser Asp Leu Val Tyr Met
185 190 195CAC GAT AAA GAC ATA GAG CTT TTA ACC CAT CTT AAA GAT TAT GTC ATG 681His Asp Lys Asp Ile Glu Leu Leu Thr His Leu Lys Asp Tyr Val Met
200 205 210CCT ATA AAA GAT AAA ATC CCC CTT TAT ACA GAC TAT GGG GAT TTT TAC 729Pro Ile Lys Asp Lys Ile Pro Leu Tyr Thr Asp Tyr Gly Asp Phe Tyr
215 220 225ACC AAC GCC AGA GTG GGC GAA TTG TTC GCT CTC ATC CCC CAA AGT CAA 777Thr Asn Ala Arg Val Gly Glu Leu Phe Ala Leu Ile Pro Gln Ser Gln
230 235 240AAA ACA CCT CAA AAA CCC CAA AAA AAG GAA TTG AAA GCC TAT GGT TTT 825Lys Thr Pro Gln Lys Pro Gln Lys Lys Glu Leu Lys Ala Tyr Gly Phe245 250 255 260TTG AGA GAC GCT AAG GGT TAT GCA GCT TTA CAA AGC GTG ATC TTA GAA 873Leu Arg Asp Ala Lys Gly Tyr Ala Ala Leu Gln Ser Val Ile Leu Glu
265 270 275GAA AAG GAT TTT TTT GTT TTC CCT AAG GCT TTT AAC AGC GAG AAC ATG 921Glu Lys Asp Phe Phe Val Phe Pro Lys Ala Phe Asn Ser Glu Asn Met
280 285 290GCG TAT TTT ATA GAC ACC ATG TTA GGG CAA AAA TAC GGC TGG GGC GGG 969Ala Tyr Phe Ile Asp Thr Met Leu Gly Gln Lys Tyr Gly Trp Gly Gly
295 300 305CTA TTG GGT AAT AGG GAT TGC TCG GCT TTC ACC AGA GAT AGT TTT GCT 1017Leu Leu Gly Asn Arg Asp Cys Ser Ala Phe Thr Arg Asp Ser Phe Ala
310 315 320AAT TTT GGT ATT TTG CTC CCC AGA AAT TCC TAT GCG CAA AGC CGT TAT 1065Asn Phe Gly Ile Leu Leu Pro Arg Asn Ser Tyr Ala Gln Ser Arg Tyr325 330 335 340GCG AAC AAT TAT GTG GAT TTA AGC TCT ATG AAA GCC AAA GAA AAA GAA 1113Ala AsnAsn Tyr Val Asp Leu Ser Ser Met Lys Ala Lys Glu Lys Glu
345 350 355GAC TAC ATC CTT AAA AAC GCC ACG CCT TTT GGA ACG CTC ATC TAT TTA 1161Asp Tyr Ile Leu Lys Asn Ala Thr Pro Phe Gly Thr Leu Ile Tyr Leu
360 365 370AAA GGG CAT ATC ATG CTT TAT TTA GGC GCA CAC AAC CAT CAA GCG ATA 1209Lys Gly His Ile Met Leu Tyr Leu Gly Ala His Asn His Gln Ala Ile
375 380 385GTC GCT CAC AGC ATT TGG TCG GTG CAA ACC CAA AAG CAT TTT AAA ACC 1257Val Ala His Ser Ile Trp Ser Val Gln Thr Gln Lys His Phe Lys Thr
390 395 400TTG AGC CAT AAA ATA GGA GGC GTG GTG ATC ACT TCG TTA TGG TTA GCT 1305Leu Ser His Lys Ile Gly Gly Val Val Ile Thr Ser Leu Trp Leu Ala405 410 415 420GAA GAG CAT AAT GGG GCG TTT TCT AAA AAG AAA TTA TTG ATT GAT AGG 1353Glu Glu His Asn Gly Ala Phe Ser Lys Lys Lys Leu Leu Ile Asp Arg
425 430 435GTG CTT GGA ATG AGC GAT TTG AAA GAT TTT GTC AAT AAA ACT TCA AGC 1401Val Leu Gly Met Ser Asp Leu Lys Asp Phe Val Asn Lys Thr Ser Ser
440 445 450CCT TTA AAT GCG AAT TGATTTTCTT ATATTATGAT TACGATTTAT CAATTTAAAA C 1457Pro Leu Asn Ala Asn
455ATTTGGAGAA AGA 1470
(2) Sequence 168 data:
(i) sequence characteristics:
(A) length: 457 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 168: met Arg Tyr Phe Leu Val Val Phe Leu Phe Leu Phe Val Gly Cys Thr 151015 Lys Lys Asp Phe Thr Leu Lys Asp Leu Ser Leu Pro Gln Glu Ala Ser
20 25 30Ser Tyr Leu Ala Ser Ser Gln Asn Gly Ser Asn Asn Asn Gln Ser Ile
35 40 45Asp Pro Gln Ala Leu Arg Glu Asn Leu Lys Glu Ser Tyr Leu Lys Ala
50 55 60Trp Tyr Ser Pro Trp Leu Asp Met Lys Val Lys Ser Asn Lys Lys Glu65 70 75 80Val Phe Trp Ile Leu Lys Glu Met Asn Lys Ser Thr Gly Tyr Gly Glu
85 90 95Asp Leu Lys Pro Asn Ala Lys Ala Phe Asn Asp Ala Leu Ile Lys Ser
100 105 110Met Asp Ile Glu His Tyr Pro Ser Val Lys Ile Arg Ala Val Val Ala
115 120 125Arg Asp Ser Asp Val Arg Ala Val Pro Thr Asn Lys Pro Tyr Tyr Leu
130 135 140Ser Gln Lys Gly Tyr Pro Phe Asp Arg Tyr Gln Asn Ser Leu Ile Phe145 150 155 160Gln Gly Thr Pro Val Leu Ile Thr His Phe Asn Leu Asp Lys Thr Tyr
165 170 175Ala His Ile Gln Ser Ser Phe Val Tyr Gly Trp Ile Lys Val Ser Asp
180 185 190Leu Val Tyr Met His Asp Lys Asp Ile Glu Leu Leu Thr His Leu Lys
195 200 205Asp Tyr Val Met Pro Ile Lys Asp Lys Ile Pro Leu Tyr Thr Asp Tyr
210 215 220Gly Asp Phe Tyr Thr Asn Ala Arg Val Gly Glu Leu Phe Ala Leu Ile225 230 235 240Pro Gln Ser Gln Lys Thr Pro Gln Lys Pro Gln Lys Lys Glu Leu Lys
245 250 255Ala Tyr Gly Phe Leu Arg Asp Ala Lys Gly Tyr Ala Ala Leu Gln Ser
260 265 270Val Ile Leu Glu Glu Lys Asp Phe Phe Val Phe Pro Lys Ala Phe Asn
275 280 285Ser Glu Asn Met Ala Tyr Phe Ile Asp Thr Met Leu Gly Gln Lys Tyr
290 295 300Gly Trp Gly Gly Leu Leu Gly Asn Arg Asp Cys Ser Ala Phe Thr Arg305 310 315 320Asp Ser Phe Ala Asn Phe Gly Ile Leu Leu Pro Arg Asn Ser Tyr Ala
325 330 335Gln Ser Arg Tyr Ala Asn Asn Tyr Val Asp Leu Ser Ser Met Lys Ala
340 345 350Lys Glu Lys Glu Asp Tyr Ile Leu Lys Asn Ala Thr Pro Phe Gly Thr
355 360 365Leu Ile Tyr Leu Lys Gly His Ile Met Leu Tyr Leu Gly Ala His Asn
370 375 380His Gln Ala Ile Val Ala His Ser Ile Trp Ser Val Gln Thr Gln Lys385 390 395 400His Phe Lys Thr Leu Ser His Lys Ile Gly Gly Val Val Ile Thr Ser
405 410 415Leu Trp Leu Ala Glu Glu His Asn Gly Ala Phe Ser Lys Lys Lys Leu
420 425 430Leu Ile Asp Arg Val Leu Gly Met Ser Asp Leu Lys Asp Phe Val Asn
435 440 445Lys Thr Ser Ser Pro Leu Asn Ala Asn
450 455
(2) Sequence 169 data:
(i) sequence characteristics:
(A) length: 235bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...182
(D) Other information:
(xi) Description of the sequence: sequence 169: CTTTTACTTT ATAATTATCG TTGGCATTTT AATATTCAAA GGAGCTTGAA ATG AGA 56
Met Arg
1ATT TCT CTT TTA GCT GTA ATT TTA GCG TTA TTG TTT GTG GCT TGC CAC 104Ile Ser Leu Leu Ala Val Ile Leu Ala Leu Leu Phe Val Ala Cys His
5 10 15GAA ACT AAA AAA CAA ATC TTA CAA AAC GAA GCC GAT AGC ACC CCT TCA 152Glu Thr Lys Lys Gln Ile Leu Gln Asn Glu Ala Asp Ser Thr Pro Ser
20 25 30GAA AAA ACC ATT TGG CAA CCT GAA CAA AAA TAAAAATTGT AAAAATACTC AAA 205Glu Lys Thr Ile Trp Gln Pro Glu Gln Lys35 40GGCATTTTTT AAAATAAACG CAATAAAAAA 235
(2) Sequence 170 data:
(i) sequence characteristics:
(A) length: 44 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 170: met Arg Ile Ser Leu Leu Ala Val Ile Leu Ala Leu Leu Phe Val Ala 151015 Cys His Glu Thr Lys Lys Gln Ile Leu Gln Asn Glu Ala Asp Ser Thr
20 25 30Pro Ser Glu Lys Thr Ile Trp Gln Pro Glu Gln Lys
35 40
(2) Sequence 171 data:
(i) sequence characteristics:
(A) length: 1351bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1298
(D) Other information:
(xi) Description of the sequence: sequence 171: CCAGCGATGC GTCCTGTTAA AAACGATTTT AATGTGGAGA GTGAAGAATA ATG GCG 56
Met Ala
1TAT TTT TTA GAA CAA ACG GAT AGT GAA ATT TTT GAG CTT ATC TTT GAA 104Tyr Phe Leu Glu Gln Thr Asp Ser Glu Ile Phe Glu Leu Ile Phe Glu
5 10 15GAA TAC AAGCGG CAA AAT GAG CAT TTA GAA ATG ATA GCG AGC GAG AAT 152Glu Tyr Lys Arg Gln Asn Glu His Leu Glu Met Ile Ala Ser Glu Asn
20 25 30TAC ACT TTT GCA AGC GTT ATG GAG GCT ATG GGG AGT GTT TTA ACG AAT 200Tyr Thr Phe Ala Ser Val Met Glu Ala Met Gly Ser Val Leu Thr Asn35 40 45 50AAA TAC GCT GAA GGC TAC CCT AAC AAG CGC TAT TAT GGA GGC TGT GAA 248Lys Tyr Ala Glu Gly Tyr Pro Asn Lys Arg Tyr Tyr Gly Gly Cys Glu
55 60 65GTG GTG GAT AAA ATA GAA AGC CTA GCC ATA GAA AGG GCT AAA AAG CTT 296Val Val Asp Lys Ile Glu Ser Leu Ala Ile Glu Arg Ala Lys Lys Leu
70 75 80TTT AAT TGC CAG TTC GCT AAC GTG CAA GCG CAT TCA GGC TCA CAA GCC 344Phe Asn Cys Gln Phe Ala Asn Val Gln Ala His Ser Gly Ser Gln Ala
85 90 95AAT AAC GCT GTC TAT CAC GCT CTT TTA AAG CCT TAT GAC AAG ATT TTA 392Asn Asn Ala Val Tyr His Ala Leu Leu Lys Pro Tyr Asp Lys Ile Leu
100 105 110GGC ATG GAT TTA AGC TGT GGA GGG CAT TTA ACG CAT GGC GCT AAA GTG 440Gly Met Asp Leu Ser Cys Gly Gly His Leu Thr His Gly Ala Lys Val115 120 125 130AGT TTA ACC GGC AAG CAT TAT CAG AGC TTT TCT TAT GGC GTG AAT TTG 488Ser Leu Thr Gly Lys His Tyr Gln Ser Phe Ser Tyr Gly Val Asn Leu
135 140 145GAT GGC TAT ATT GAT TAT GAA GAG GCG CTA AAA ATC GCT CAA AGC GTT 536Asp Gly Tyr Ile Asp Tyr Glu Glu Ala Leu Lys Ile Ala Gln Ser Val
150 155 160AAG CCA GAA ATC ATC GTG TGC GGG TTT TCA GCC TAT CCA AGG GAG ATT 584Lys Pro Glu Ile Ile Val Cys Gly Phe SerAla Tyr Pro Arg Glu Ile
165 170 175GAT TTT AAG AAA TTT AGA GAA ATC GCT GAT GAA GTG GGG GCG TTA CTA 632Asp Phe Lys Lys Phe Arg Glu Ile Ala Asp Glu Val Gly Ala Leu Leu
180 185 190TTA GGC GAT ATA GCC CAT GTG GCA GGG CTT GTG GTA ACC GGT GAG CAT 680Leu Gly Asp Ile Ala His Val Ala Gly Leu Val Val Thr Gly Glu His195 200 205 210GCC CAT CCT TTC CCG CAT TGC CAT GTG GTT TCA AGC ACC ACT CAT AAG 728Ala His Pro Phe Pro His Cys His Val Val Ser Ser Thr Thr His Lys
215 220 225ACC TTA AGA GGG CCT AGA GGG GGG ATT ATT TTA ACT AAT GAT GAA GAG 776Thr Leu Arg Gly Pro Arg Gly Gly Ile Ile Leu Thr Asn Asp Glu Glu
230 235 240ATA GCG GCT AAG ATT GAC AAA GCG ATT TTT CCA GGA ACT CAA GGC GGG 824Ile Ala Ala Lys Ile Asp Lys Ala Ile Phe Pro Gly Thr Gln Gly Gly
245 250 255CCT TTG ATG CAT GTG ATT GCT GCT AAA GCG GTG GGT TTT AAA GAG AAT 872Pro Leu Met His Val Ile Ala Ala Lys Ala Val Gly Phe Lys Glu Asn
260 265 270CTA AAA CCA GAA TTT AAA GCT TAT GCA CAA TTA GTG AAA TCT AAC ATG 920Leu Lys Pro Glu Phe Lys Ala Tyr Ala Gln Leu Val Lys Ser Asn Met275 280 285 290CAA GTT TTG GCT AAA GCG TTA AAA GAA AAA AAC CAT AAG TTA GTG AGT 968Gln Val Leu Ala Lys Ala Leu Lys Glu Lys Asn His Lys Leu Val Ser
295 300 305GGT GGC ACT TCT AAC CAT TTG CTT TTA ATG GAT TTT TTA GAT AAG CCT 1016Gly Gly Thr Ser Asn His Leu Leu Leu Met Asp Phe Leu Asp Lys Pro
310 315 320TAT AGC GGG AAA GAC GCT GAT ATT GCA TTA GGG AAT GCC GGA ATC ACC 1064Tyr Ser Gly Lys Asp Ala Asp Ile Ala Leu Gly Asn Ala Gly Ile Thr
325 330 335GTG AAT AAA AAC ACC ATT CCT GGT GAA ACG CGC AGC CCT TTT GTA ACG 1112Val Asn Lys Asn Thr Ile Pro Gly Glu Thr Arg Ser Pro Phe Val Thr
340 345 350AGC GGG ATA AGG ATT GGC TCA GCG GCA TTG AGC GCA AGG GGC ATG GGA 1160Ser Gly Ile Arg Ile Gly Ser Ala Ala Leu Ser Ala Arg Gly Met Gly355 360 365 370GCT AAG GAA TTT GAA ATC ATA GGG AAT AAA ATA TCA GAT ATT TTG AAT 1208Ala Lys Glu Phe Glu Ile Ile Gly Asn Lys Ile Ser Asp Ile Leu Asn
375 380 385GAT ATT AAT AAT GTT AGT TTG CAA TTG CAT GTG AAA GAA GAA TTG AAA 1256Asp Ile Asn Asn Val Ser Leu Gln Leu His Val Lys Glu Glu Leu Lys
390 395 400GCC ATG GTC AAT CAA TTC CCT GTG TAC CAC CAA CCT ATT TTT TAAGGGAGT 1307Ala Met Val Asn Gln Phe Pro Val Tyr His Gln Pro Ile Phe
405 410 415CAAGATGACA GAAATGGAAT TAAAGCTCAT TAAGATAGAC ACAA 1351
(2) Sequence 172 data:
(i) sequence characteristics:
(A) length: 416 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 172: met Ala Tyr Phe Leu Glu Gln Thr Asp Ser Glu Ile Phe Glu Leu Ile 151015 Phe Glu Glu Tyr Lys Arg Gln AsnGlu His Leu Glu Met Ile Ala Ser
20 25 30Glu Asn Tyr Thr Phe Ala Ser Val Met Glu Ala Met Gly Ser Val Leu
35 40 45Thr Asn Lys Tyr Ala Glu Gly Tyr Pro Asn Lys Arg Tyr Tyr Gly Gly
50 55 60Cys Glu Val Val Asp Lys Ile Glu Ser Leu Ala Ile Glu Arg Ala Lys65 70 75 80Lys Leu Phe Asn Cys Gln Phe Ma Asn Val Gln Ala His Ser Gly Ser
85 90 95Gln Ala Asn Asn Ala Val Tyr His Ala Leu Leu Lys Pro Tyr Asp Lys
100 105 110Ile Leu Gly Met Asp Leu Ser Cys Gly Gly His Leu Thr His Gly Ala
115 120 125Lys Val Ser Leu Thr Gly Lys His Tyr Gln Ser Phe Ser Tyr Gly Val
130 135 140Asn Leu Asp Gly Tyr Ile Asp Tyr Glu Glu Ala Leu Lys Ile Ala Gln145 150 155 160Ser Val Lys Pro Glu Ile Ile Val Cys Gly Phe Ser Ala Tyr Pro Arg
165 170 175Glu Ile Asp Phe Lys Lys Phe Arg Glu Ile Ala Asp Glu Val Gly Ala
180 185 190Leu Leu Leu Gly Asp Ile Ala His Val Ala Gly Leu Val Val Thr Gly
195 200 205Glu His Ala His Pro Phe Pro His Cys His Val Val Ser Ser Thr Thr
210 215 220His Lys Thr Leu Arg Gly Pro Arg Gly Gly Ile Ile Leu Thr Asn Asp225 230 235 240Glu Glu Ile Ala Ala Lys Ile Asp Lys Ala Ile Phe Pro Gly Thr Gln
245 250 255Gly Gly Pro Leu Met His Val Ile Ala Ala Lys Ala Val Gly Phe Lys
260 265 270Glu Asn Leu Lys Pro Glu Phe Lys Ala Tyr Ala Gln Leu Val Lys Ser
275 280 285Asn Met Gln Val Leu Ala Lys Ala Leu Lys Glu Lys Asn His Lys Leu
290 295 300Val Ser Gly Gly Thr Ser Asn His Leu Leu Leu Met Asp Phe Leu Asp305 310 315 320Lys Pro Tyr Ser Gly Lys Asp Ala Asp Ile Ala Leu Gly Asn Ala Gly
325 330 335Ile Thr Val Asn Lys Asn Thr Ile Pro Gly Glu Thr Arg Ser Pro Phe
340 345 350Val Thr Ser Gly Ile Arg Ile Gly Ser Ala Ala Leu Ser Ala Arg Gly
355 360 365Met Gly Ala Lys Glu Phe Glu Ile Ile Gly Asn Lys Ile Ser Asp Ile
370 375 380Leu Asn Asp Ile Asn Asn Val Ser Leu Gln Leu His Val Lys Glu Glu385 390 395 400Leu Lys Ala Met Val Asn Gln Phe Pro Val Tyr His Gln Pro Ile Phe
405 410 415
(2) Data in sequence 173:
(i) sequence characteristics:
(A) length: 1513bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1460
(D) Other information:
(xi) Description of the sequence: sequence 173: TGAAAAACCA CTCCTTTAAA AAAACGATCG CTCTTTCCTT ACTAGCGAGC ATG TCT 56
Met Ser
1TTG TGC AGG GCT GAA GAA GAT GGG GCG TTT TTT GTC ATA GAT TAC CAG 104Leu Cys Arg Ala Glu Glu Asp Gly Ala Phe Phe Val Ile Asp Tyr Gln
5 10 15ACG AGT TTG GCC AGA CAG GAA TTG AAA AAT CCA GGC TTC ACC CAA GCG 152Thr Ser Leu Ala Arg Gln Glu Leu Lys Asn Pro Gly Phe Thr Gln Ala
20 25 30CAA GAA TTA AGG CAG TTG ATC AGA GAT GGG GCT GTG AGG TTG CAA ACT 200Gln Glu Leu Arg Gln Leu Ile Arg Asp Gly Ala Val Arg Leu Gln Thr35 40 45 50TCT GCC ATT CCC TTA TCC TAC TAC TTG GAT ATT TTA GGG AAT AAA ACA 248Ser Ala Ile Pro Leu Ser Tyr Tyr Leu Asp Ile Leu Gly Asn Lys Thr
55 60 65GCA ACT CTT TTG CGT GAA AGC CTG AAA AAC AAT GCA CAA CCA TCA CAA 296Ala Thr Leu Leu Arg Glu Ser Leu Lys Asn Asn Ala Gln Pro Ser Gln
70 75 80CCA AAC GCG CAA CCA CCG CAA CAA AAC GGA CCA TCA AAC CAA GCC TTA 344Pro Asn Ala Gln Pro Pro Gln Gln Asn Gly Pro Ser Asn Gln Ala Leu
85 90 95GCC AAT TTA GAG CAA TCT CTA GGG ATT TTA GGA AAA CTA TTG GAT CTA 392Ala Asn Leu Glu Gln Ser Leu Gly Ile Leu Gly Lys Leu Leu Asp Leu
100 105110TCC CAA CAA TAC GCT AGT CAG GGT GTC ATT AAG CCT TTG GTG GTG GAT 440Ser Gln Gln Tyr Ala Ser Gln Gly Val Ile Lys Pro Leu Val Val Asp115 120 125 130GTG GGG AAA GAA CAA ATC GGT ATC ACG GAT AGC ATG CTC TTG GTG GCT 488Val Gly Lys Glu Gln Ile Gly Ile Thr Asp Ser Met Leu Leu Val Ala
135 140 145CAA AAC ATC GTT TTA GCT TTA GGG CAA GTG GAT TTG AGC AAA ATC CAA 536Gln Asn Ile Val Leu Ala Leu Gly Gln Val Asp Leu Ser Lys Ile Gln
150 155 160CAA AAC AAT AAC GAA CAG CTA TAC GAA AAT ATT ATG AAA GTC ATG CTT 584Gln Asn Asn Asn Glu Gln Leu Tyr Glu Asn lle Met Lys Val Met Leu
165 170 175TTA GGC GCG GGC GGG ACT AAT GGG GCG TAT AAT GGC GTG AGT GTG GGC 632Leu Gly Ala Gly Gly Thr Asn Gly Ala Tyr Asn Gly Val Ser Val Gly
180 185 190GAC ATT GCC ACG GGC ATG CAA AAT TTT TCT TCG CAA ACG GGC TTG ATA 680Asp Ile Ala Thr Gly Met Gln Asn Phe Ser Ser Gln Thr Gly Leu Ile195 200 205 210GGG GCT AAT TCT ACG GTT AGC GAG CTG AAT GCT TTG ATT AAG AGC GGG 728Gly Ala Asn Ser Thr Val Ser Glu Leu Asn Ala Leu Ile Lys Ser Gly
215 220 225ATT TCT TTG GAT CGT GAG ACT TTG GGG TTA GGG AGT TTT ATT GAA AAA 776Ile Ser Leu Asp Arg Glu Thr Leu Gly Leu Gly Ser Phe Ile Glu Lys
230 235 240AAT ATC TGT AGC GGT GCA TCG TCT TGT TTT AGT GGG AAT CAG CTT ATC 824Asn Ile Cys Ser Gly Ala Ser Ser Cys Phe Ser Gly Asn Gln Leu Ile
245 250 255TAT AAG AAA GGG CTA GAC AGA ACC ATA AAC ATC ATT AAT ACG GTA TTA 872Tyr Lys Lys Gly Leu Asp Arg Thr IleAsn Ile Ile Asn Thr Val Leu
260 265 270GGT CAG TTT GAA TCT TCG GCT AGT TCT CTT TAT AAG ATT TCT TAT ATC 920Gly Gln Phe Glu Ser Ser Ala Ser Ser Leu Tyr Lys Ile Ser Tyr Ile275 280 285 290CCT AAC CTC TTT TCG CTC AAG GAT TAC CAG TCA GCG AGC ATG AAC GGC 968Pro Asn Leu Phe Ser Leu Lys Asp Tyr Gln Ser Ala Ser Met Asn Gly
295 300 305TTT GGG GCT AAG ATG GGC TAT AAA CAA TTT TTC ACC CAT AAG AAA AAT 1016Phe Gly Ala Lys Met Gly Tyr Lys Gln Phe Phe Thr His Lys Lys Asn
310 315 320GTT GGC TTA AGG TAT TAC GGG TTT TTG GAT TAT GGC TAT GCG AAC TTT 1064Val Gly Leu Arg Tyr Tyr Gly Phe Leu Asp Tyr Gly Tyr Ala Asn Phe
325 330 335GGC GAT ACG AAT TTA AAA GTG GGG GCG AAT CTT GTT ACT TAT GGG GTA 1112Gly Asp Thr Asn Leu Lys Val Gly Ala Asn Leu Val Thr Tyr Gly Val
340 345 350GGA ACG GAT TTT TTA TAC AAT GTG TAT GAA CGC TCT AGA AGG AGG GAA 1160Gly Thr Asp Phe Leu Tyr Asn Val Tyr Glu Arg Ser Arg Arg Arg Glu355 360 365 370AGG ACT ACG ATC GGT CTT TTC TTT GGC GCT CAA ATT GCA GGG CAA ACT 1208Arg Thr Thr Ile Gly Leu Phe Phe Gly Ala Gln Ile Ala Gly Gln Thr
375 380 385TGG AGC ACT AAT GTA ACG AAC TTA TTG AGC GGG CAA AGG CCT GAT GTC 1256Trp Ser Thr Asn Val Thr Asn Leu Leu Ser Gly Gln Arg Pro Asp Val
390 395 400AAG TCC AGT TCG TTC CAA TTC TTG TTT GAT TTG GGC GTG CGC ACC AAC 1304Lys Ser Ser Ser Phe Gln Phe Leu Phe Asp Leu Gly Val Arg Thr Asn
405410 415TTT GCA AAA ACC AAT TTC AAT AAG CAC AGG CTA GAC CAA GGG ATA GAA 1352Phe Ala Lys Thr Asn Phe Asn Lys His Arg Leu Asp Gln Gly Ile Glu
420 425 430TTT GGG GTG AAA ATC CCT GTT ATC GCT CAT AAA TAT TTT GCA ACC CAA 1400Phe Gly Val Lys Ile Pro Val Ile Ala His Lys Tyr Phe Ala Thr Gln435 440 445 450GGC TCA AGC GCG AGC TAT ATG AGG AAT TTT AGC TTC TAT GTG GGC TAT 1448Gly Ser Ser Ala Ser Tyr Met Arg Asn Phe Ser Phe Tyr Val Gly Tyr
455 460 465TCA GTC GGT TTT TAAGGAAGGC TCTTGATGAA AAATACCAAT ACAAAAGAGA TAAAG 1505Ser Val Gly Phe
470AATACAAG 1513
(2) Sequence 174 data:
(i) sequence characteristics:
(A) length: 470 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 174: met Ser Leu Cys Arg Ala Glu Glu Asp Gly Ala Phe Phe Val Ile Asp 151015 Tyr Gln Thr Ser Leu Ala Arg Gln Glu Leu Lys Asn Pro Gly Phe Thr
20 25 30Gln Ala Gln Glu Leu Arg Gln Leu Ile Arg Asp Gly Ala Val Arg Leu
35 40 45Gln Thr Ser Ala Ile Pro Leu Ser Tyr Tyr Leu Asp Ile Leu Gly Asn
50 55 60Lys Thr Ala Thr Leu Leu Arg Glu Ser Leu Lys Asn Asn Ala Gln Pro65 70 75 80Ser Gln Pro Asn Ala Gln Pro Pro Gln Gln Asn Gly Pro Ser Asn Gln
85 90 95Ala Leu Ala Asn Leu Glu Gln Ser Leu Gly Ile Leu Gly Lys Leu Leu
100 105 110Asp Leu Ser Gln Gln Tyr Ala Ser Gln Gly Val Ile Lys Pro Leu Val
115 120 125Val Asp Val Gly Lys Glu Gln Ile Gly Ile Thr Asp Ser Met Leu Leu
130 135 140Val Ala Gln Asn Ile Val Leu Ala Leu Gly Gln Val Asp Leu Ser Lys145 150 155 160Ile Gln Gln Asn Asn Asn Glu Gln Leu Tyr Glu Asn Ile Met Lys Val
165 170 175Met Leu Leu Gly Ala Gly Gly Thr Asn Gly Ala Tyr Asn Gly Val Ser
180 185 190Val Gly Asp Ile Ala Thr Gly Met Gln Asn Phe Ser Ser Gln Thr Gly
195 200 205Leu Ile Gly Ala Asn Ser Thr Val Ser Glu Leu Asn Ala Leu Ile Lys
210 215 220Ser Gly Ile Ser Leu Asp Arg Glu Thr Leu Gly Leu Gly Ser Phe Ile225 230 235 240Glu Lys Asn Ile Cys Ser Gly Ala Ser Ser Cys Phe Ser Gly Asn Gln
245 250 255Leu Ile Tyr Lys Lys Gly Leu Asp Arg Thr Ile Asn Ile Ile Asn Thr
260 265 270Val Leu Gly Gln Phe Glu Ser Ser Ala Ser Ser Leu Tyr Lys Ile Ser
275 280 285Tyr Ile Pro Asn Leu Phe Ser Leu Lys Asp Tyr Gln Ser Ala Ser Met
290 295 300Asn Gly Phe Gly Ala Lys Met Gly Tyr Lys Gln Phe Phe Thr His Lys305 310 315 320Lys Asn Val Gly Leu Arg Tyr Tyr Gly Phe Leu Asp Tyr Gly Tyr Ala
325 330 335Asn Phe Gly Asp Thr Asn Leu Lys Val Gly Ala Asn Leu Val Thr Tyr
340 345 350Gly Val Gly Thr Asp Phe Leu Tyr Asn Val Tyr Glu Arg Ser Arg Arg
355 360 365Arg Glu Arg Thr Thr Ile Gly Leu Phe Phe Gly Ala Gln Ile Ala Gly
370 375 380Gln Thr Trp Ser Thr Asn ValThr Asn Leu Leu Ser Gly Gln Arg Pro385 390 395 400Asp Val Lys Ser Ser Ser Phe Gln Phe Leu Phe Asp Leu Gly Val Arg
405 410 415Thr Asn Phe Ala Lys Thr Asn Phe Asn Lys His Arg Leu Asp Gln Gly
420 425 430Ile Glu Phe Gly Val Lys Ile Pro Val Ile Ala His Lys Tyr Phe Ala
435 440 445Thr Gln Gly Ser Ser Ala Ser Tyr Met Arg Asn Phe Ser Phe Tyr Val
450 455 460Gly Tyr Ser Val Gly Phe465 470
(2) Sequence 175 data:
(i) sequence characteristics:
(A) length: 505bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...452
(D) Other information:
(xi) Description of the sequence: sequence 175: AAGACCCTAA ATACACACAA AATAAAACAA AATAAATCCA ATCAAATCCC ATG TGC 56
Met Cys
1CAA ATC CAA TGC TTG CTT ATT TTA CTT TCT ATC AAT ATA GTT AGC GCG 104Gln Ile Gln Cys Leu Leu Ile Leu Leu Ser Ile Asn Ile Val Ser Ala
5 10 15ATC ATC GTT TAT TTT TTC CAA GCA TTT CAA GGG GTT TTG AAT TTT GAA 152Ile Ile Val Tyr Phe Phe Gln Ala Phe Gln Gly Val Leu Asn Phe Glu
20 25 30GGG GGT TTT TTA GGG TTT TTT ATC GTG GCG TTG TCT TCG TAT TAC GGC 200Gly Gly Phe Leu Gly Phe Phe Ile Val Ala Leu Ser Ser Tyr Tyr Gly35 40 45 50GTT AAA AAG CGT TTG GAT TTA AGG AAA CAA AAT TCA ATA GAA AAA GAA 248Val Lys Lys Arg Leu Asp Leu Arg Lys Gln Asn Ser Ile Glu Lys Glu
55 60 65GAA AAG CAA AAA TTC CAA AAA TTC GCC CTG GGC TTG GAA ATG TCT TTC 296Glu Lys Gln Lys Phe Gln Lys Phe Ala Leu Gly Leu Glu Met Ser Phe
70 75 80AAT GTG TGG CGT TTA GGA GGG TAT GGG GTT TTA CTA GGC ATT TTA GGA 344Asn Val Trp Arg Leu Gly Gly Tyr Gly Val Leu Leu Gly Ile Leu Gly
85 90 95ACG CTT TTA TTC TTG CAT CTT TTT AAC GGG TTA ATC TTT CTT ATT GGC 392Thr Leu Leu Phe Leu His Leu Phe Asn Gly Leu Ile Phe Leu Ile Gly
100105 110GTG TTT GTG AGC TCG CTC TCT AGC GCG TTA TTA CGA TTT TTG AAT AAT 440Val Phe Val Ser Ser Leu Ser Ser Ala Leu Leu Arg Phe Leu Asn Asn115 120 125 130AAT GGT AAG TTT TGACACAAAC TCACATGGAT TTTAACCCCT TTAATCCTCT TTTAA 497Asn Gly Lys PheTTTTTAAT 505
(2) Sequence 176 data:
(i) sequence characteristics:
(A) length: 134 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 176: met Cys Gln Ile Gln Cys Leu Leu Ile Leu Leu Ser Ile Asn Ile Val 151015 Ser Ala Ile Ile Val Tyr Phe Phe Gln Ala Phe Gln Gly Val Leu Asn
20 25 30Phe Glu Gly Gly Phe Leu Gly Phe Phe Ile Val Ala Leu Ser Ser Tyr
35 40 45Tyr Gly Val Lys Lys Arg Leu Asp Leu Arg Lys Gln Asn Ser Ile Glu
50 55 60Lys Glu Glu Lys Gln Lys Phe Gln Lys Phe Ala Leu Gly Leu Glu Met65 70 75 80Ser Phe Asn Val Trp Arg Leu Gly Gly Tyr Gly Val Leu Leu Gly Ile
85 90 95Leu Gly Thr Leu Leu Phe Leu His Leu Phe Asn Gly Leu Ile Phe Leu
100 105 110Ile Gly Val Phe Val Ser Ser Leu Ser Ser Ala Leu Leu Arg Phe Leu
115120 125Asn Asn Asn Gly Lys Phe
130
(2) Sequence 177 data:
(i) sequence characteristics:
(A) length: 511bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...458
(D) Other information:
(xi) Description of the sequence: sequence 177: TTTTTGCACT ATCGTTGTTT GCGCTGTGGT GTTTGGCACG CTTGAAAAAA ATG CTC 56
Met Leu
1AAG AGT ACC ATC AAA GAA GAT TAT TTG ATG CTG ATG TCT AGA GAA GTG 104Lys Ser Thr Ile Lys Glu Asp Tyr Leu Met Leu Met Ser Arg Glu Val
5 10 15AGT GCT TTT GTG GGG ACT CTT TTC TTC ATT GGC TTG AGT TGC TAT GCG 152Ser Ala Phe Val Gly Thr Leu Phe Phe Ile Gly Leu Ser Cys Tyr Ala
20 25 30ATC TAT CAT GGC AAC ATG CCC GAT TAT TTG AGA CCG GCT TTG ATA GAC 200Ile Tyr His Gly Asn Met Pro Asp Tyr Leu Arg Pro Ala Leu Ile Asp35 40 45 50ACT ATT AAG GCA GCG AGT GAT TCC ATC TAT TCC AGC TGC GAC TAC ATG 248Thr Ile Lys Ala Ala Ser Asp Ser Ile Tyr Ser Ser Cys Asp Tyr Met
55 60 65GAT TAT TTT TTG AAG GCT AGA AAG ATG TTA GAG GGG TTT GCT TGG TGG 296Asp Tyr Phe Leu Lys Ala Arg Lys Met Leu Glu Gly Phe Ala Trp Trp
70 75 80AGC ATG TTC AAA GCG GAG AGC ATG GGC TTA AAT AAG GGG TTT ATG GTT 344Ser Met Phe Lys Ala Glu Ser Met Gly Leu Asn Lys Gly Phe Met Val
85 90 95GCG GGC TGG GTA GCG TTT ATC ATC TAT AAC GCT CTT AGC GGG ATA GCC 392Ala Gly Trp Val Ala Phe Ile Ile Tyr Asn Ala Leu Ser Gly Ile Ala
100 105 110ATC AGC AGG CTG AGC GCT CAA ATC ATT TAT TGG TTA TCA AAA TAT TTT 440Ile Ser Arg Leu Ser Ala Gln Ile Ile Tyr Trp Leu Ser Lys Tyr Phe115 120 125 130AGG AGT GAG TAT GGA AAA TGATGTTAAA GAAGATCTAG AGCAAGCAAG ACCAAAGT 496Arg Ser Glu Tyr Gly Lys
135TAGAGCCAGA AAAGC 511
(2) Sequence 178 data:
(i) sequence characteristics:
(A) length: 136 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 178: met Leu Lys Ser Thr Ile Lys Glu Asp Tyr Leu Met Leu Met Ser Arg 151015 Glu Val Ser Ala Phe Val Gly Thr Leu Phe Phe Ile Gly Leu Ser Cys
20 25 30Tyr Ala Ile Tyr His Gly Asn Met Pro Asp Tyr Leu Arg Pro Ala Leu
35 40 45Ile Asp Thr Ile Lys Ala Ala Ser Asp Ser Ile Tyr Ser Ser Cys Asp
50 55 60Tyr Met Asp Tyr Phe Leu Lys Ala Arg Lys Met Leu Glu Gly Phe Ala65 70 75 80Trp Trp Ser Met Phe Lys Ala Glu Ser Met Gly Leu Asn Lys Gly Phe
85 90 95Met Val Ala Gly Trp Val Ala Phe Ile Ile Tyr Asn Ala Leu Ser Gly
100 105 110Ile Ala Ile Ser Arg Leu Ser Ala Gln Ile Ile Tyr Trp Leu Ser Lys
115 120 125Tyr Phe Arg Ser Glu Tyr Gly Lys
130 135
(2) Sequence 179 data:
(i) sequence characteristics:
(A) length: 2203bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...2150
(D) Other information:
(xi) Description of the sequence: sequence 179: GAGTTACACA CTCTTTGAGA ACAAAACGCC AAACCATTTA GGAAATTACC ATG CTA 56
Met Leu
1AGA TTC GTT AGT AAA ACG ATT TGC TTG TCT TTA ATC GGC TTG TTC AAC 104Arg Phe Val Ser Lys Thr Ile Cys Leu Ser Leu Ile Gly Leu Phe Asn
5 10 15CCT TTA GAA GCC TTT CAA AAA CAC CAA AAA GAC GGC TTT TTT ATA GAA 152Pro Leu Glu Ala Phe Gln Lys His Gln Lys Asp Gly Phe Phe Ile Glu
20 25 30GCT GGG TTT GAA ACT GGG TTA TTA GAA GGA ACG CAA ACT AAA GAA GAA 200Ala Gly Phe Glu Thr Gly Leu Leu Glu Gly Thr Gln Thr Lys Glu Glu35 40 45 50GTC ATA ACC ACC CAA AAA ATC TAT GAA AAC CCC CTA ACC CAC CCA CAA 248Val Ile Thr Thr Gln Lys Ile Tyr Glu Asn Pro Leu Thr His Pro Gln
55 60 65ACT AAA GAA CAG CCT AAA GAA CAA AAT AAA AGC GAT ACG GCC ACC CCA 296Thr Lys Glu Gln Pro Lys Glu Gln Asn Lys Ser Asp Thr Ala Thr Pro
70 75 80CAA AGC GCT TAC GGA AAA TAC TAC ATA CCC CAA AGC ACC ATT TTA AAA 344Gln Ser Ala Tyr Gly Lys Tyr Tyr Ile Pro Gln Ser Thr Ile Leu Lys
85 90 95AAT GCA ACG GCT TTA TTC ACC ACG GAC AAG ATA GAA AAT GGC TTA ACT 392Asn Ala Thr Ala Leu Phe Thr Thr Asp Lys Ile Glu Asn Gly Leu Thr
100 105 110TTT TAT TCT CAA AAC CCT GTG TAT GCG AAT ATG GTT AAT GGG AGC GTA 440Phe Tyr Ser Gln Asn Pro Val Tyr Ala Asn Met Val Asn Gly Ser Val115 120 125 130ACC ATA CAA AAC TTT CTG CCT TAT AAT TTA AAC AAT GTT GAA CTG AGT 488Thr Ile Gln Asn Phe Leu Pro Tyr Asn Leu Asn Asn Val Glu Leu Ser
135 140 145TTT AAA GAC GCT CAA GGC AAG GTG GTC AAT TTA GGC GTG ATA GAG ACC 536Phe Lys Asp Ala Gln Gly Lys Val Val Asn Leu Gly Val Ile Glu Thr
150 155 160ATC CCT AAA CAA TCT CAA ATT ACC TTG CCT GCA AGC TTG TTT AAT GAT 584Ile Pro Lys Gln Ser Gln Ile Thr Leu Pro Ala Ser Leu Phe Asn Asp
165170 175TCA GAA TTT GAA CAA GCT GAT AGC TTT AAT TAC CAA CAA CTT CAA GCC 632Ser Glu Phe Glu Gln Ala Asp Ser Phe Asn Tyr Gln Gln Leu Gln Ala
180 185 190ACT GCC ACA CAA TTT TCT GAC GCT AAC ACG CAA AGT TTG TTT CAA AAG 680Thr Ala Thr Gln Phe Ser Asp Ala Asn Thr Gln Ser Leu Phe Gln Lys195 200 205 210CTC AGC AAG ATC ACA ACC AAT GTA ACA ATG AGT TAT GAA AAC GCC GAT 728Leu Ser Lys Ile Thr Thr Asn Val Thr Met Ser Tyr Glu Asn Ala Asp
215 220 225ACC AAC AAT TTT AAA GGT AAT TGC CAT GAT TGT GTG TCA GAT TTC ACC 776Thr Asn Asn Phe Lys Gly Asn Cys His Asp Cys Val Ser Asp Phe Thr
230 235 240CCA CAA ACC GCA GAA GAA TTG ACC AAT TTA ATG CTA GAT ATG ATT GCG 824Pro Gln Thr Ala Glu Glu Leu Thr Asn Leu Met Leu Asp Met Ile Ala
245 250 255GTG TTT GAC TCT AAA TCG TGG GAA GAA GCC GTT TTA AAC GCT CCT TTC 872Val Phe Asp Ser Lys Ser Trp Glu Glu Ala Val Leu Asn Ala Pro Phe
260 265 270CAA TTT TCT AAC AGC TCA TCA GAG TGC GGC TCT GAC TTT CCT AAG TGC 920Gln Phe Ser Asn Ser Ser Ser Glu Cys Gly Ser Asp Phe Pro Lys Cys275 280 285 290GTG AAT CCT TTC AAT AAC GGG CGT GTC GCT CCC ATC TAT GAA AAA TAC 968Val Asn Pro Phe Asn Asn Gly Arg Val Ala Pro Ile Tyr Glu Lys Tyr
295 300 305GTG CTA ACC CCA CAA TCC GTT ATA GAT GCG TTT AGA AGA ACG ATC AAT 1016Val Leu Thr Pro Gln Ser Val Ile Asp Ala Phe Arg Arg Thr Ile Asn
310 315 320CTT GAA GTG AAT ATC CTA AAA TCA GGG TTT GTA GGG CTA GGG TAT GAA 1064Leu Glu Val Asn Ile Leu Lys Ser Gly Phe Val Gly Leu Gly Tyr Glu
325 330 335CTT GAT GAT AAT GAT GGT AAT CTG GGG ATA GAA GCT TCT GCC TTA AAT 1112Leu Asp Asp Asn Asp Gly Asn Leu Gly Ile Glu Ala Ser Ala Leu Asn
340 345 350CCT GAA AAA TTG TTT GGT AAA ACT TTG AAC AAA GTT GAT ATT GTG GAA 1160Pro Glu Lys Leu Phe Gly Lys Thr Leu Asn Lys Val Asp Ile Val Glu355 360 365 370TTA AGA GAC ATT ATC CAT GAA TTT AGC CAC ACT AAA GGC TAT ACG CAT 1208Leu Arg Asp Ile Ile His Glu Phe Ser His Thr Lys Gly Tyr Thr His
375 380 385AAT GGG AAC ATG ACT TAT CAA AGA GTG CGC TTG TGT CAA GAA AAC GGC 1256Asn Gly Asn Met Thr Tyr Gln Arg Val Arg Leu Cys Gln Glu Asn Gly
390 395 400GGA GCC ATA CAA GAA TGT GAG GGT GGG AAA GAA GAG TTA GTC AAT GGA 1304Gly Ala Ile Gln Glu Cys Glu Gly Gly Lys Glu Glu Leu Val Asn Gly
405 410 415AAA GAA GAA CTA AAA TTT ACA AAT GGG AAA GAA GTG AAA GAT CAG GAT 1352Lys Glu Glu Leu Lys Phe Thr Asn Gly Lys Glu Val Lys Asp Gln Asp
420 425 430GGT TAC ACC TAT GAT GTA TGT TCT TTT TAT AAG GAC AAC CAC CAA GTC 1400Gly Tyr Thr Tyr Asp Val Cys Ser Phe Tyr Lys Asp Asn His Gln Val435 440 445 450TAT ACA GCG AGC AAT TAC CCC AAT TCC ATT TAT ACG AAT TGC GCT CAA 1448Tyr Thr Ala Ser Asn Tyr Pro Asn Ser Ile Tyr Thr Asn Cys Ala Gln
455 460 465GTC CCT GCT GGG CTT ATA GGG GTT ACC ACC GCT GTC TGG CAA CAG CTC 1496Val Pro Ala Gly Leu Ile Gly Val Thr Thr Ala Val Trp Gln Gln Leu
470 475 480ATC AAT CAA AAC GCT CTG CCC ATT AAT TTC GCT AAT CTA AAT AGC CCA 1544Ile Asn Gln Asn Ala Leu Pro Ile Asn Phe Ala Asn Leu Asn Ser Pro
485 490 495ACC AAC CAC TTA AAC GCC GGG TTG AAC GCA CAA AAT TTT GCA ACC TCT 1592Thr Asn His Leu Asn Ala Gly Leu Asn Ala Gln Asn Phe Ala Thr Ser
500 505 510ATA GTC AGC GCG ATC GCG CAA AAT TTT TCC ACC ACT TCC ACC ACC ACT 1640Ile Val Ser Ala Ile Ala Gln Asn Phe Ser Thr Thr Ser Thr Thr Thr515 520 525 530TAC CGC TCT TCA AGT AAG AAT TTT AGA AGC CCT ATT TTA GGG GTT AAT 1688Tyr Arg Ser Ser Ser Lys Asn Phe Arg Ser Pro Ile Leu Gly Val Asn
535 540 545GTT AAA ATA GGC TAC CAA CAT TAT TTC AAT GAC TAC ATA GGG TTA GCC 1736Val Lys Ile Gly Tyr Gln His Tyr Phe Asn Asp Tyr Ile Gly Leu Ala
550 555 560TAT TAC GGC ATT ATC AAA TAC AAT TAC GCC AAA ACT AAC GAT GAA AAA 1784Tyr Tyr Gly Ile Ile Lys Tyr Asn Tyr Ala Lys Thr Asn Asp Glu Lys
565 570 575ATC CAG CAA TTA AGC TAT GGT GGG GGA ATG GAT GTG TTG TTT GAT TTC 1832Ile Gln Gln Leu Ser Tyr Gly Gly Gly Met Asp Val Leu Phe Asp Phe
580 585 590ATC ACC ACT TAC GCT AAC AAA AAG CAA GAC AAC CCA ACT AAA AAA GTT 1880Ile Thr Thr Tyr Ala Asn Lys Lys Gln Asp Asn Pro Thr Lys Lys Val595 600 605 610TTT GCT TCC TCT TTT GGG GTG TTT GGG GGG TTA AGG GGC TTA TAC AAT 1928Phe Ala Ser Ser Phe Gly Val Phe Gly Gly Leu Arg Gly Leu Tyr Asn
615 620 625AGC TAT TAT GTC TTC AAC CAA GTC AAA GGAAGC GGT AAT TTA GAT ATA 1976Ser Tyr Tyr Val Phe Asn Gln Val Lys Gly Ser Gly Asn Leu Asp Ile
630 635 640GTT ACT GGG TTT AAT TAC CGC TAC AAG CAT TCT AAA TAT TCT GTA GGC 2024Val Thr Gly Phe Asn Tyr Arg Tyr Lys His Ser Lys Tyr Ser Val Gly
645 650 655ATT AGC GTT CCT TTA ATC CAA AGC GGT ATT AAA ATC GCT TCT AAT AAT 2072Ile Ser Val Pro Leu Ile Gln Ser Gly Ile Lys Ile Ala Ser Asn Asn
660 665 670GGC ATC TAT GCG AAC TCC GTT GTT TTG AAT GAA GGG GGC AGT CAT TTT 2120Gly Ile Tyr Ala Asn Ser Val Val Leu Asn Glu Gly Gly Ser His Phe675 680 685 690AAA GTG TTT TTT AAT TAC GGG TGG ATT TTT TAGGATTTAA AATCCCCAAT AAC 2173Lys Val Phe Phe Asn Tyr Gly Trp Ile Phe
695 700CCCCTAAACT TGTGCGATAC TCGCTACAAA 2203
(2) Sequence 180 data:
(i) sequence characteristics:
(A) length: 700 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 180: met Leu Arg Phe Val Ser Lys Thr Ile Cys Leu Ser Leu Ile Gly Leu 151015 Phe Asn Pro Leu Glu Ala Phe Gln Lys His Gln Lys Asp Gly Phe Phe
20 25 30Ile Glu Ala Gly Phe Glu Thr Gly Leu Leu Glu Gly Thr Gln Thr Lys
35 40 45Glu Glu Val Ile Thr Thr Gln Lys Ile Tyr Glu Asn Pro Leu Thr His
50 55 60Pro Gln Thr Lys Glu Gln Pro Lys Glu Gln Asn Lys Ser Asp Thr Ala65 70 75 80Thr Pro Gln Ser Ala Tyr Gly Lys Tyr Tyr Ile Pro Gln Ser Thr Ile
85 90 95Leu Lys Asn Ala Thr Ala Leu Phe Thr Thr Asp Lys Ile Glu Asn Gly
100 105 110Leu Thr Phe Tyr Ser Gln Asn Pro Val Tyr Ala Asn Met Val Asn Gly
115 120 125Ser Val Thr Ile Gln Asn Phe Leu Pro Tyr Asn Leu Asn Asn Val Glu
130 135 140Leu Ser Phe Lys Asp Ala Gln Gly Lys Val Val Asn Leu Gly Val Ile145 150 155 160Glu Thr Ile Pro Lys Gln Ser Gln Ile Thr Leu Pro Ala Ser Leu Phe
165 170 175Asn Asp Ser Glu Phe Glu Gln Ala Asp Ser Phe Asn Tyr Gln Gln Leu
180 185 190Gln Ala Thr Ala Thr Gln Phe Ser Asp Ala Asn Thr Gln Ser Leu Phe
195 200 205Gln Lys Leu Ser Lys Ile Thr Thr Asn Val Thr Met Ser Tyr Glu Asn
210 215 220Ala Asp Thr Asn Asn Phe Lys Gly Asn Cys His Asp Cys Val Ser Asp225 230 235 240Phe Thr Pro Gln Thr Ala Glu Glu Leu Thr Asn Leu Met Leu Asp Met
245 250 255Ile Ala Val Phe Asp Ser Lys Ser Trp Glu Glu Ala Val Leu Asn Ala
260 265 270Pro Phe Gln Phe Ser Asn Ser Ser Ser Glu CysGly Ser Asp Phe Pro
275 280 285Lys Cys Val Asn Pro Phe Asn Asn Gly Arg Val Ala Pro Ile Tyr Glu
290 295 300Lys Tyr Val Leu Thr Pro Gln Ser Val Ile Asp Ala Phe Arg Arg Thr305 310 315 320Ile Asn Leu Glu Val Asn Ile Leu Lys Ser Gly Phe Val Gly Leu Gly
325 330 335Tyr Glu Leu Asp Asp Asn Asp Gly Asn Leu Gly Ile Glu Ala Ser Ala
340 345 350Leu Asn Pro Glu Lys Leu Phe Gly Lys Thr Leu Asn Lys Val Asp Ile
355 360 365Val Glu Leu Arg Asp Ile Ile His Glu Phe Ser His Thr Lys Gly Tyr
370 375 380Thr His Asn Gly Asn Met Thr Tyr Gln Arg Val Arg Leu Cys Gln Glu385 390 395 400Asn Gly Gly Ala Ile Gln Glu Cys Glu Gly Gly Lys Glu Glu Leu Val
405 410 415Asn Gly Lys Glu Glu Leu Lys Phe Thr Asn Gly Lys Glu Val Lys Asp
420 425 430Gln Asp Gly Tyr Thr Tyr Asp Val Cys Ser Phe Tyr Lys Asp Asn His
435 440 445Gln Val Tyr Thr Ala Ser Asn Tyr Pro Asn Ser Ile Tyr Thr Asn Cys
450 455 460Ala Gln Val Pro Ala Gly Leu Ile Gly Val Thr Thr Ala Val Trp Gln465 470 475 480Gln Leu Ile Asn Gln Asn Ala Leu Pro Ile Asn Phe Ala Asn Leu Asn
485 490 495Ser Pro Thr Asn His Leu Asn Ala Gly Leu Asn Ala Gln Asn Phe Ala
500 505 510Thr Ser Ile Val Ser Ala Ile Ala Gln Asn Phe Ser Thr Thr Ser Thr
515 520 525Thr Thr Tyr Arg Ser Ser Ser Lys Asn Phe Arg Ser Pro Ile Leu Gly
530 535 540Val Asn Val Lys Ile Gly Tyr Gln His Tyr Phe Asn Asp Tyr Ile Gly545 550 555 560Leu Ala Tyr Tyr Gly Ile Ile Lys Tyr Asn Tyr Ala Lys Thr Asn Asp
565 570 575Glu Lys Ile Gln Gln Leu Ser Tyr Gly Gly Gly Met Asp Val Leu Phe
580 585 590Asp Phe Ile Thr Thr Tyr Ala Asn Lys Lys Gln Asp Asn Pro Thr Lys
595 600 605Lys Val Phe Ala Ser Ser Phe Gly Val Phe Gly Gly Leu Arg Gly Leu
610 615 620Tyr Asn Ser Tyr Tyr Val Phe Asn Gln Val Lys Gly Ser Gly Asn Leu625 630 635 640Asp Ile Val Thr Gly Phe Asn Tyr Arg Tyr Lys His Ser Lys Tyr Ser
645 650 655Val Gly Ile Ser Val Pro Leu Ile Gln Ser Gly Ile Lys Ile Ala Ser
660 665 670Asn Asn Gly Ile Tyr Ala Asn Ser Val Val Leu Asn Glu Gly Gly Ser
675 680 685His Phe Lys Val Phe Phe Asn Tyr Gly Trp Ile Phe
690 695 700
(2) Sequence 181 data:
(i) sequence characteristics:
(A) length: 397bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...344
(D) Other information:
(xi) Description of the sequence: sequence 181: TCGTTTTGGA AAAAGATATA GCCCATGCGC GTTTCAAGGG TAATGAAAGC ATG GTG 56
Met Val
1TAT GAA GAA AAT TTT GTG CAT GCC GGG TTT GTG CTT ATT GCG TGC AAT 104Tyr Glu Glu Asn Phe Val His Ala Gly Phe Val Leu Ile Ala Cys Asn
5 10 15TAT GCG GCC TTG TGC GCG TTG AAT AAA AGA CAC AGC GTG GTG GTT TCT 152Tyr Ala Ala Leu Cys Ala Leu Asn Lys Arg His Ser Val Val Val Ser
20 25 30AAT AAC ATC AAT TTT TAT GCC CCC CTA GAA TTG AAT CAA GAA GCA CTC 200Asn Asn Ile Asn Phe Tyr Ala Pro Leu Glu Leu Asn Gln Glu Ala Leu35 40 45 50ATT AAA GCG CAA GTG ATT CAA GAT GGC GTG AAA AAA GGT GAA ATA AAA 248Ile Lys Ala Gln Val Ile Gln Asp Gly Val Lys Lys Ala Glu Ile Lys
55 60 65ATA GAG GCG TTT GTG TTA GAC ATT CAG GTT TTA GAG GGA ATG ATA GAA 296Ile Glu Ala Phe Val Leu Asp Ile Gln Val Leu Glu Gly Met Ile Glu
70 75 80ATT GTG GTG TTT GAT AAA AAG CCT TTT AAA TTC AAT TTT AAA GAA GAG T 345Ile Val Val Phe Asp Lys Lys Pro Phe Lys Phe Asn Phe Lys Glu Glu
85 90 95AGTTAAATGG TTATTGTTTT AGTCGTGGAT AGTTTTAAAG ACACCAGTAA TG 397
(2) Sequence 182 data:
(i) sequence characteristics:
(A) length: 98 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 182: met Val Tyr Glu Glu Asn Phe Val His Ala Gly Phe Val Leu Ile Ala 151015 Cys Asn Tyr Ala Ala Leu Cys Ala Leu Asn Lys Arg His Ser Val Val
20 25 30Val Ser Asn Asn Ile Asn Phe Tyr Ala Pro Leu Glu Leu Asn Gln Glu
35 40 45Ala Leu Ile Lys Ala Gln Val Ile Gln Asp Gly Val Lys Lys Ala Glu
50 55 60Ile Lys Ile Glu Ala Phe Val Leu Asp Ile Gln Val Leu Glu Gly Met65 70 75 80Ile Glu Ile Val Val Phe Asp Lys Lys Pro Phe Lys Phe Asn Phe Lys
85 90 95Glu Glu
(2) Sequence 183 data:
(i) sequence characteristics:
(A) length: 1261bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1208
(D) Other information:
(xi) Description of the sequence: sequence 183: ATGATAGTAA GGAAATAAGA GTGGAATGCA AGAATCACCC TATTGAAAAG ATG GCA 56
Met Ala
1GAA AAA TTA GAG GAA ACT AAT CCT GAA TGG TTT GAA AAA TGG AGG GAA 104Glu Lys Leu Glu Glu Thr Asn Pro Glu Trp Phe Glu Lys Trp Arg Glu
5 10 15AAA CAA TAC ACC CAA ACT GGC GAA TCT AAG CCA TCA AAA CGA ATC AAA 152Lys Gln Tyr Thr Gln Thr Gly Glu Ser Lys Pro Ser Lys Arg Ile Lys
20 25 30GTT TTT AAA AAC TTT ACG GCA TTT GAT GAC AGA TTG TAT ACA ATT GAA 200Val Phe Lys Asn Phe Thr Ala Phe Asp Asp Arg Leu Tyr Thr Ile Glu35 40 45 50TGT AAT TTA AAA AAT CTG GAT ACC CAT CAA AAA AAG TTT GAA ATT TGT 248Cys Asn Leu Lys Asn Leu Asp Thr His Gln Lys Lys Phe Glu Ile Cys
55 60 65GGG GCT CTG TAT GAC ATT TAT GAA CAA ATT TTT GAT GAA ACA CCA AGC 296Gly Ala Leu Tyr Asp Ile Tyr Glu Gln Ile Phe Asp Glu Thr Pro Ser
70 75 80TTG AAA GGG CGC GAT TTA GAA ACA TAC AAA GCA CAA GAT TTG TCA AAG 344Leu Lys Gly Arg Asp Leu Glu Thr Tyr Lys Ala Gln Asp Leu Ser Lys
85 90 95AAA TTC ATG CAT TTA GGT TTT GAA CAG ATC TCA AAA GAT TTA AAC GAC 392Lys Phe Met His Leu Gly Phe Glu Gln Ile Ser Lys Asp Leu Asn Asp
100 105 110TCT AGA TTG AAC GCTTTA TTG TGC TAT GAG GAA AAA GTC ATG CAA GCT 440Ser Arg Leu Asn Ala Leu Leu Cys Tyr Glu Glu Lys Val Met Gln Ala115 120 125 130TTG GCT AAA AAA TAC CCT AGT TTT TTA CAA GAT TTG CAT GAT ATA AAA 488Leu Ala Lys Lys Tyr Pro Ser Phe Leu Gln Asp Leu His Asp Ile Lys
135 140 145AAA TAC AGG AAT AAA GAT AAA CAC GGC GAG AAA CCA CAA GAT GGG TCT 536Lys Tyr Arg Asn Lys Asp Lys His Gly Glu Lys Pro Gln Asp Gly Ser
150 155 160TCT TTA ACG AGA GTG GAA TTA GAA AGA TAC AGA GAT GGA ATT TAT TTT 584Ser Leu Thr Arg Val Glu Leu Glu Arg Tyr Arg Asp Gly Ile Tyr Phe
165 170 175CTA GTA GAA AAT CTT TTA AAA AAC CCC TTG ATT AAA GAG AGA GAA AAT 632Leu Val Glu Asn Leu Leu Lys Asn Pro Leu Ile Lys Glu Arg Glu Asn
180 185 190GCT CAA GAA GAA AAA CAT TAT AAG AAA AAT GCA GAG ATT GAC GAC CGA 680Ala Gln Glu Glu Lys His Tyr Lys Lys Asn Ala Glu Ile Asp Asp Arg195 200 205 210TCC CAG CTA TCA AAC TTA AAC GCA CCC AAA CCC TTA TTT GAA TGT TTT 728Ser Gln Leu Ser Asn Leu Asn Ala Pro Lys Pro Leu Phe Glu Cys Phe
215 220 225GTA GGA GTT AAT CTG GCC AAA GCC AAA TAT TAT TCT AAA AAA GAA GAA 776Val Gly Val Asn Leu Ala Lys Ala Lys Tyr Tyr Ser Lys Lys Glu Glu
230 235 240AGA GAA AAA GAA AAG ATG ATC TTG AAT TTT TGT AAG ATA TTT GAA ATT 824Arg Glu Lys Glu Lys Met Ile Leu Asn Phe Cys Lys Ile Phe Glu Ile
245 250 255ATT CTT TTT GAA GCT ATC CAA AAA CAA CCA AAG CCT GAT TTT AAA AAT 872Ile Leu Phe Glu Ala Ile Gln Lys Gln Pro Lys Pro Asp Phe Lys Asn
260 265 270AAA GAC GAG CTT TTA GGG GAT TAT CCT AAT CTT AAA AAT TTA GAT TCT 920Lys Asp Glu Leu Leu Gly Asp Tyr Pro Asn Leu Lys Asn Leu Asp Ser275 280 285 290TTA AGA GAA GTG AGG GAA GAC TTT TTG AAA AGA GCG TTT AAG AAT GAT 968Leu Arg Glu Val Arg Glu Asp Phe Leu Lys Arg Ala Phe Lys Asn Asp
295 300 305GAA GCG AGT TTG GGA GCG TAT GTG TTA GTG TTG CTT AGC TGT AAG TAT 1016Glu Ala Ser Leu Gly Ala Tyr Val Leu Val Leu Leu Ser Cys Lys Tyr
310 315 320TTT GAG AGC GTG TTT GAA AAA GTT CAA GAA TGG CTA GAT TTT ATC GCT 1064Phe Glu Ser Val Phe Glu Lys Val Gln Glu Trp Leu Asp Phe Ile Ala
325 330 335AGG CTT ATT GCT TTG AGA GGC CAT GTG CAC AAG ATA ACT AAA GAA CTT 1112Arg Leu Ile Ala Leu Arg Gly His Val His Lys Ile Thr Lys Glu Leu
340 345 350GAA AGA TTA GAA GAA GAG GAT TTA GAA AAA TTG GAA AAA CAA GCA CTA 1160Glu Arg Leu Glu Glu Glu Asp Leu Glu Lys Leu Glu Lys Gln Ala Leu355 360 365 370GAA TAT TTT AAT AAA ATA GCA AAT AAA ATA TAT CTA AAG GAG AAA CGA T 1209Glu Tyr Phe Asn Lys Ile Ala Asn Lys Ile Tyr Leu Lys Glu Lys Arg
375 380 385GAGCGGGAAT GAAGAATTGG AGCTAAGAGC CAGAGAAACT GAGTTGGATA AA 1261
(2) Sequence 184 data:
(i) sequence characteristics:
(A) length: 386 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 184: met Ala Glu Lys Leu Glu Glu Thr Asn Pro Glu Trp Phe Glu Lys Trp 151015 Arg Glu Lys Gln Tyr Thr Gln Thr Gly Glu Ser Lys Pro Ser Lys Arg
20 25 30Ile Lys Val Phe Lys Asn Phe Thr Ala Phe Asp Asp Arg Leu Tyr Thr
35 40 45Ile Glu Cys Asn Leu Lys Asn Leu Asp Thr His Gln Lys Lys Phe Glu
50 55 60Ile Cys Gly Ala Leu Tyr Asp Ile Tyr Glu Gln Ile Phe Asp Glu Thr65 70 75 80Pro Ser Leu Lys Gly Arg Asp Leu Glu Thr Tyr Lys Ala Gln Asp Leu
85 90 95Ser Lys Lys Phe Met His Leu Gly Phe Glu Gln Ile Ser Lys Asp Leu
100 105 110Asn Asp Ser Arg Leu Asn Ala Leu Leu Cys Tyr Glu Glu Lys Val Met
115 120 125Gln Ala Leu Ala Lys Lys Tyr Pro Ser Phe Leu Gln Asp Leu His Asp
130 135 140Ile Lys Lys Tyr Arg Asn Lys Asp Lys His Gly Glu Lys Pro Gln Asp145 150 155 160Gly Ser Ser Leu Thr Arg Val Glu Leu Glu Arg Tyr Arg Asp Gly Ile
165 170 175Tyr Phe Leu Val Glu Asn Leu Leu Lys Asn Pro Leu Ile Lys Glu Arg
180 185 190Glu Asn Ala Gln Glu Glu Lys His Tyr Lys Lys Asn Ala Glu Ile Asp
195 200 205Asp Arg Ser Gln Leu Ser Asn Leu Asn Ala Pro Lys Pro Leu Phe Glu
210 215 220Cys Phe Val Gly Val Asn Leu Ala Lys Ala Lys Tyr Tyr Ser Lys Lys225 230 235 240Glu Glu Arg Glu Lys Glu Lys Met Ile Leu Asn Phe Cys Lys Ile Phe
245 250 255Glu Ile Ile Leu Phe Glu Ala Ile Gln Lys Gln Pro Lys Pro Asp Phe
260 265 270Lys Asn Lys Asp Glu Leu Leu Gly Asp Tyr Pro Asn Leu Lys Asn Leu
275 280 285Asp Ser Leu Arg Glu Val Arg Glu Asp Phe Leu Lys Arg Ala Phe Lys
290 295 300Asn Asp Glu Ala Ser Leu Gly Ala Tyr Val Leu Val Leu Leu Ser Cys305 310 315 320Lys Tyr Phe Glu Ser Val Phe Glu Lys Val Gln Glu Trp Leu Asp Phe
325 330 335Ile Ala Arg Leu Ile Ala Leu Arg Gly His Val His Lys Ile Thr Lys
340 345 350Glu Leu Glu Arg Leu Glu Glu Glu Asp Leu Glu Lys Leu Glu Lys Gln
355 360 365Ala Leu Glu Tyr Phe Asn Lys Ile Ala Asn Lys Ile Tyr Leu Lys Glu
370 375 380Lys Arg385
(2) Sequence 185 data:
(i) sequence characteristics:
(A) length: 412bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...359
(D) Other information:
(xi) Description of the sequence: sequence 185: CATTTAATGC TAAGTCTAAT AAGATTGCCC TAGATAGACA TTACGCCAAA ATG TTT 56
Met Phe
1TTG CAA GTT GTA GCA AGA ACT CTA AGA AAG AAT GTC AAT ATA TTA GAA 104Leu Gln Val Val Ala Arg Thr Leu Arg Lys Asn Val Asn Ile Leu Glu
5 10 15GAG CAA GGT TTT ATT GAA GTC ATT AAA GGA AAA CAA AGA TAC TTG TAT 152Glu Gln Gly Phe Ile Glu Val Ile Lys Gly Lys Gln Arg Tyr Leu Tyr
20 25 30GTG TAT CTT AAA GAT TAC AGA GAA TTA GAG GGC TAT AAC TCC GTA GGA 200Val Tyr Leu Lys Asp Tyr Arg Glu Leu Glu Gly Tyr Asn Ser Val Gly35 40 45 50GCT AAT CAA AAG AAC AAT ATC CCA TCG CCT TTT TTC TTA CAG ATT ATG 248Ala Asn Gln Lys Asn Asn Ile Pro Ser Pro Phe Phe Leu Gln Ile Met
55 60 65CGT TTC TTA GAA AAG TTT GCC AAA GAA ATT GAG AGA GTA AAA ATA ACA 296Arg Phe Leu Glu Lys Phe Ala Lys Glu Ile Glu Arg Val Lys Ile Thr
70 75 80ACA AAG AAT GTG TTA TGC ATA TTC CTA GCC AAG AGC TTA TGC AAA GAG 3 44Thr Lys Asn Val Leu Cys Ile Phe Leu Ala Lys Ser Leu Cys Lys Glu
85 90 95TTA ATA ATG TTG TTT TAAAATTCAC GCCTATTTCT AATCCTAATA CCACTTACAC T 400Leu Ile Met Leu Phe
100TTATCCTACA AG412
(2) Sequence 186 data:
(i) sequence characteristics:
(A) length: 103 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 186: met Phe Leu Gln Val Val Ala Arg Thr Leu Arg Lys Asn Val Asn Ile 151015 Leu Glu Glu Gln Gly Phe Ile Glu Val Ile Lys Gly Lys Gln Arg Tyr
20 25 30Leu Tyr Val Tyr Leu Lys Asp Tyr Arg Glu Leu Glu Gly Tyr Asn Ser
35 40 45Val Gly Ala Asn Gln Lys Asn Asn Ile Pro Ser Pro Phe Phe Leu Gln
50 55 60Ile Met Arg Phe Leu Glu Lys Phe Ala Lys Glu Ile Glu Arg Val Lys65 70 75 80Ile Thr Thr Lys Asn Val Leu Cys Ile Phe Leu Ala Lys Ser Leu Cys
85 90 95Lys Glu Leu Ile Met Leu Phe
100
(2) Sequence 187 data:
(i) sequence characteristics:
(A) length: 1204bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1151
(D) Other information:
(xi) Description of the sequence: sequence 187: TTCTATTAAA ATTAGTGTAT GATTGAGATT ATTTTTGATT AGGATCAACC ATG CAA 56
Met Gln
1AAA GCC TTA TTA CAT TCA TCA TTC TTT TTA CCT TTA TTT TTA TCT TTT 104Lys Ala Leu Leu His Ser Ser Phe Phe Leu Pro Leu Phe Leu Ser Phe
5 10 15TGT ATC GCT GAA GAA AAT GGG GCG TAT GCG AGC GTG GGT TTT GAA TAT 152Cys Ile Ala Glu Glu Asn Gly Ala Tyr Ala Ser Val Gly Phe Glu Tyr
20 25 30TCC ATT AGT CAT GCC GTT GAA CAC AAT AAC CCC TTT TTA AAT CAA GAA 200Ser Ile Ser His Ala Val Glu His Asn Asn Pro Phe Leu Asn Gln Glu35 40 45 50CGC ATC CAA ATC ATT TCT AAC GCT CAA AAT AAA ATC TAT AAA CTC CAT 248Arg Ile Gln Ile Ile Ser Asn Ala Gln Asn Lys Ile Tyr Lys Leu His
55 60 65CAA GTT AAA AAT GAA ATC ACA AGC ATG CCT AAA ACC TTT GCA TAT ATC 296Gln Val Lys Asn Glu Ile Thr Ser Met Pro Lys Thr Phe Ala Tyr Ile
70 75 80AAC AAC GCT TTA AAA AAC AAC TCC AAA TTA ACC CCC ACT GAA ATG CAA 344Asn Asn Ala Leu Lys Asn Asn Ser Lys Leu Thr Pro Thr Glu Met Gln
85 90 95GCC GAA CAA TAC TAC CTC CAA TCC ACC TTT CAA AAC ATT GAA AAA ATA 392Ala Glu Gln Tyr Tyr Leu Gln Ser Thr Phe Gln Asn Ile Glu Lys Ile
100 105 110GTA ATG CTT AGC GGT GGC GTT TCA TCT AAC CCA CAA TTA GTC CAA GCG 440Val Met Leu Ser Gly Gly Val Ser Ser Asn Pro Gln Leu Val Gln Ala115 120 125 130TTG GAA AAA ATG CAA GAA CCC ATT ACT AAC CCT TTA GAA TTT GAA GAA 488Leu Glu Lys Met Gln Glu Pro Ile Thr Asn Pro Leu Glu Phe Glu Glu
135 140 145AAC TTA AGA AAT TTA GAA GTG CAA TTT GCT CAA TCT CAA AAC CGC ATG 536Asn Leu Arg Asn Leu Glu Val Gln Phe Ala Gln Ser Gln Asn Arg Met
150 155 160CTT TCT TCT TTA TCT TCT CAA ATC GCT GCC ATT TCA AAT TCC TTA AAC 584Leu Ser Ser Leu Ser Ser Gln Ile Ala Ala Ile Ser Asn Ser Leu Asn
165 170 175GCG CTT GAT CCT AAC TCT TAT TCT AAA AAC ATT TCA AGC ATG TAT GGG 632Ala Leu Asp Pro Asn Ser Tyr Ser Lys Asn Ile Ser Ser Met Tyr Gly
180 185 190GTG AGT TTG AGC GTA GGT TAT AAG CAT TTC TTT ACC AAG AAA AAA AAT 680Val Ser Leu Ser Val Gly Tyr Lys His Phe Phe Thr Lys Lys Lys Asn195 200 205 210CAA GGG TTG CGC TAT TAC TTG TTT TAT GAC TAT GGT TAC ACT AAT TTT 728Gln Gly Leu Arg Tyr Tyr Leu Phe Tyr Asp Tyr Gly Tyr Thr Asn Phe
215 220 225GGT TTT GTG GGC AAT GGC TTT GAT GGT TTA GGC AAA ATG AAT AAC CAT 776Gly Phe Val Gly Asn Gly Phe Asp Gly Leu Gly Lys Met Asn Asn His
230 235 240CTC TAT GGG CTT GGG ATA GAC TAT CTT TAT AAT TTC ATT GAT AAT GCA 824Leu Tyr Gly Leu Gly Ile Asp Tyr Leu Tyr Asn Phe Ile Asp Asn Ala
245 250 255AAA AAA CAC TCT AGC GTA GGT TTT TAT CTG GGT TTT GCT TTA GCG GGG 872Lys Lys His Ser Ser Val Gly Phe Tyr Leu Gly Phe Ala Leu Ala Gly
260 265 270AGT TCG TGG GTA GGG AGT GGT TTG AGC ATG TGG GTG AGC CAA ACG GAT 920Ser Ser Trp Val Gly Ser Gly Leu Ser Met Trp Val Ser Gln Thr Asp275 280 285 290TTT ATC AAC AAT TAC TTG ACG GGC TAT CAA GCT AAA ATG CAC ACG AGT 968Phe Ile Asn Asn Tyr Leu Thr Gly Tyr Gln Ala Lys Met His Thr Ser
295 300 305TTT TTC CAG ATC CCT TTG AAT TIT GGG GTT CGT GTG AAT GTC AAT AGG 1016Phe Phe Gln Ile Pro Leu Asn Phe Gly Val Arg Val Asn Val Asn Arg
310 315 320CAT AAT GGC TTT GAA ATG GGC TTG AAA ATC CCT TTA GCG ATG AAT TCC 1064His Asn Gly Phe Glu Met Gly Leu Lys Ile Pro Leu Ala Met Asn Ser
325 330 335TTT TAT GAA ACG CAT GGC AAA GGG CTA AAC ACT TCC CTC TTT TTC AAA 1112Phe Tyr Glu Thr His Gly Lys Gly Leu Asn Thr Ser Leu Phe Phe Lys
340 345 350CGC CTT GTC ATG TTT AAC GTG AGT TAC GTT TAT AGT TTT TAGGGGGGTA AA 1163Arg Leu Val Met Phe Asn Val Ser Tyr Val Tyr Ser Phe355 360 365TGCCTTCAAA CGCTCTTTTG ATTGAAGAAA TCACTCATTT A 1204
(2) Sequence 188 data:
(i) sequence characteristics:
(A) length: 367 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 188: met Gln Lys Ala Leu Leu His Ser Ser Phe Phe Leu Pro Leu Phe Leu 151015 Ser Phe Cys Ile Ala Glu Glu Asn Gly Ala Tyr Ala Ser Val Gly Phe
20 25 30Glu Tyr Ser Ile Ser His Ala Val Glu His Asn Asn Pro Phe Leu Asn
35 40 45Gln Glu Arg Ile Gln Ile Ile Ser Asn Ala Gln Asn Lys Ile Tyr Lys
50 55 60Leu His Gln Val Lys Asn Glu Ile Thr Ser Met Pro Lys Thr Phe Ala65 70 75 80Tyr Ile Asn Asn Ala Leu Lys Asn Asn Ser Lys Leu Thr Pro Thr Glu
85 90 95Met Gln Ala Glu Gln Tyr Tyr Leu Gln Ser Thr Phe Gln Asn Ile Glu
100 105 110Lys Ile Val Met Leu Ser Gly Gly Val Ser Ser Asn Pro Gln Leu Val
115 120 125Gln Ala Leu Glu Lys Met Gln Glu Pro Ile Thr Asn Pro Leu Glu Phe
130 135 140Glu Glu Asn Leu Arg Asn Leu Glu Val Gln Phe Ala Gln Ser Gln Asn145 150 155 160Arg Met Leu Ser Ser Leu Ser Ser Gln Ile Ala Ala Ile Ser Asn Ser
165 170 175Leu Asn Ala Leu Asp Pro Asn Ser Tyr Ser Lys Asn Ile Ser Ser Met
180 185 190Tyr Gly Val Ser Leu Ser Val Gly Tyr Lys His Phe Phe Thr Lys Lys
195 200 205Lys Asn Gln Gly Leu Arg Tyr Tyr Leu Phe Tyr Asp Tyr Gly Tyr Thr
210 215 220Asn Phe Gly Phe Val Gly Asn Gly Phe Asp Gly Leu Gly Lys Met Asn225 230 235 240Asn His Leu Tyr Gly Leu Gly Ile Asp Tyr Leu Tyr Asn Phe Ile Asp
245 250 255Asn Ala Lys Lys His Ser Ser Val Gly Phe Tyr Leu Gly Phe Ala Leu
260 265 270Ala Gly Ser Ser Trp Val Gly Ser Gly Leu Ser Met Trp Val Ser Gln
275 280 285Thr Asp Phe Ile Asn Asn Tyr Leu Thr Gly Tyr Gln Ala Lys Met His
290 295 300Thr Ser Phe Phe Gln Ile Pro Leu Asn Phe Gly Val Arg Val Asn Val305 310 315 320Asn Arg His Asn Gly Phe Glu Met Gly Leu Lys Ile Pro Leu Ala Met
325 330 335Asn Ser Phe Tyr Glu Thr His Gly Lys Gly Leu Asn Thr Ser Leu Phe
340 345 350Phe Lys Arg Leu Val Met Phe Asn Val Ser Tyr Val Tyr Ser Phe
355 360 365
(2) Sequence 189 data:
(i) sequence characteristics:
(A) length: 1687bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1634
(D) Other information:
(xi) Description of the sequence: sequence 189: TTATTTTTAC AGAGTAATTT ATCTATTCTC AGGTAAAGTA AGGAAGAGGA ATG AAA 56
Met Lys
1TTA AAG AAA CGA AAA GTT GCG GCT GCA TTG CTA AAG CGT TTT ACC TTG 104Leu Lys Lys Arg Lys Val Ala Ala Ala Leu Leu Lys Arg Phe Thr Leu
5 10 15CCA CTA TTG TTC ACT ACG GGT TCA TTA GGG GCG GTT ACT TAT GAA GTG 152Pro Leu Leu Phe Thr Thr Gly Ser Leu Gly Ala Val Thr Tyr Glu Val
20 25 30CAT GGA GAT TTT ATC AAT TTT GCT AAA GTG GGT TTT AAC CAT TCG CCC 200His Gly Asp Phe Ile Asn Phe Ala Lys Val Gly Phe Asn His Ser Pro35 40 45 50ATT AAT CCT GTT AAA GGT ATC TAT CCC ACA GAA ACT TTT GTT AAC CTT 248Ile Asn Pro Val Lys Gly Ile Tyr Pro Thr Glu Thr Phe Val Asn Leu
55 60 65ACG GGT AAG CTA GAG GGG TCT GTG CAT TTA GGT AGG GGA TGG ACC GTG 296Thr Gly Lys Leu Glu Gly Ser Val His Leu Gly Arg Gly Trp Thr Val
70 75 80AAT TTA GGC GGT GTT TTG GGC GGA CAG GCT TAT GAT GGC ACT AAG TAT 344Asn Leu Gly Gly Val Leu Gly Gly Gln Ala Tyr Asp Gly Thr Lys Tyr
85 90 95GAT AGG TGG GCG AAG GAT TTT ACC CCC CCA AGC TAT TGG GAT AAA ACT 392Asp Arg Trp Ala Lys Asp Phe Thr Pro Pro Ser Tyr Trp Asp Lys Thr
100 105 110TCT TGC GGT ACT GAT TCT ATG AGT CTT TGT ATG AAT GCC ACT AAA ATG 440Ser Cys Gly Thr Asp Ser Met Ser Leu Cys Met Asn Ala Thr Lys Met115 120 125 130TGG CAG CAA TCA GGG CCA GGT GGC GTC ATT AAC CCT AGA GGT ATT GGT 488Trp Gln Gln Ser Gly Pro Gly Gly Val Ile Asn Pro Arg Gly Ile Gly
135 140 145TGG GAA TAC ATG GGT GAG TGG AAC GGC TTG TTC CCT AAC TAC TAT CCG 536Trp Glu Tyr Met Gly Glu Trp Asn Gly Leu Phe Pro Asn Tyr Tyr Pro
150 155 160GCT AAC GCC TAC TTG CCT GGT GGC TCA AGG CGC TAT CAA GTC TAT AAA 584Ala Asn Ala Tyr Leu Pro Gly Gly Ser Arg Arg Tyr Gln Val Tyr Lys
165 170 175GCA AAT TTG ACC TAT GAT AGC GAC AGG GTC CAT ATG GTA ATG GGG CGT 632Ala Asn Leu Thr Tyr Asp Ser Asp Arg Val His Met Val Met Gly Arg
180 185 190TTT GAC ATT ACC GAG CAG GAG CAA ATG GAT TGG ATT TAC CAA TTG TTC 680Phe Asp Ile Thr Glu Gln Glu Gln Met Asp Trp Ile Tyr Gln Leu Phe195 200 205 210CAA GGG TTT TAT GGG ACT TTC AAG CTC ACT AAG AAT ATG AAA TTC TTG 728Gln Gly Phe Tyr Gly Thr Phe Lys Leu Thr Lys Asn Met Lys Phe Leu
215 220 225CTC TTT AGT GGT TGG GGT CGT GGT ATC GCT GAT GGT CAG TGG TTG TTC 776Leu Phe Ser Gly Trp Gly Arg Gly Ile Ala Asp Gly Gln Trp Leu Phe
230 235 240CCT ATC TAT CGT GAA AAG CCT TGG GGG GTT CAT AAA GCG GGT ATT ATT 824Pro Ile Tyr Arg Glu Lys Pro Trp Gly Val His Lys Ala Gly Ile Ile
245 250 255TAT CGC CCT ACA AAG AAT TTG ATG ATC CAC CCT TAT GTG TAT CTT ATC 872Tyr Arg Pro Thr Lys Asn Leu Met Ile His Pro Tyr Val Tyr Leu Ile
260 265 270CCA ATG GTA GGC ACA TTG CCT GGT GCT AAA ATA GAA TAC GAT ACC AAT 920Pro Met Val Gly Thr Leu Pro Gly Ala Lys Ile Glu Tyr Asp Thr Asn275 280 285 290CCT GAA TTT AGC GGT AGG GGC ATT AGG AAC AGA ACG ACTTTC TAT GCG 968Pro Glu Phe Ser Gly Arg Gly Ile Arg Asn Arg Thr Thr Phe Tyr Ala
295 300 305TTG TAT GAC TAT CGT TGG AAT AAC GCT GAA TAC GGT CGT TAC GCG CCC 1016Leu Tyr Asp Tyr Arg Trp Asn Asn Ala Glu Tyr Gly Arg Tyr Ala Pro
310 315 320GCT CGT TAT AAC ACT TGG GAT CCG TTC TTG GAT AAT GGT AAG TGG CGT 1064Ala Arg Tyr Asn Thr Trp Asp Pro Phe Leu Asp Asn Gly Lys Trp Arg
325 330 335GGC TTG CAA GGT CCT GGT GGT GCG ACG CTC CTT TTA CGC CAC CAT ATA 1112Gly Leu Gln Gly Pro Gly Gly Ala Thr Leu Leu Leu Arg His His Ile
340 345 350GAT ATT AAC AAC TAC TTT GTG GTT GGT GGT GCT TAT CTC AAC ATT GGT 1160Asp Ile Asn Asn Tyr Phe Val Val Gly Gly Ala Tyr Leu Asn Ile Gly355 360 365 370AAC CCT AAC ATG AAC TTA GGT ACT TGG GGT AAC CCT GTG GCT GTT GAT 1208Asn Pro Asn Met Asn Leu Gly Thr Trp Gly Asn Pro Val Ala Val Asp
375 380 385GGT ATC GAA CAA TGG GTC GGT AGT ATC TAT AGC TTA GGG TTT GCG GGG 1256Gly Ile Glu Gln Trp Val Gly Ser Ile Tyr Ser Leu Gly Phe Ala Gly
390 395 400ATT GAC AAC ATT ACC GAT GCT GAC GCG TTC ACC GAG TAT GTT AAA GGT 1304Ile Asp Asn Ile Thr Asp Ala Asp Ala Phe Thr Glu Tyr Val Lys Gly
405 410 415GGA GGC AAG CAT GGT AAG TTT AGT TGG AGC GTT TAT CAG CGC TTC ACT 1352Gly Gly Lys His Gly Lys Phe Ser Trp Ser Val Tyr Gln Arg Phe Thr
420 425 430ACC GCT CCA AGG GCT TTG GAA TAT GGT ATC GGT ATG TAT CTA GAC TAT 1400Thr Ala Pro Arg Ala Leu Glu Tyr Gly Ile Gly Met Tyr Leu Asp Tyr435 440445 450CAG TTC AGC AAG CAT GTT AAA GCG GGT CTC AAA CTC GTA TGG TTA GAG 1448Gln Phe Ser Lys His Val Lys Ala Gly Leu Lys Leu Val Trp Leu Glu
455 460 465TTC CAA ATT CGT GCG GGT TAC AAC CCT GGA ACC GGT TTC CTT GGG CCA 1496Phe Gln Ile Arg Ala Gly Tyr Asn Pro Gly Thr Gly Phe Leu Gly Pro
470 475 480AAC GGT CAG CCG CTT AAC TTG AAT ACT GGT TTG TTT GAG TCT TCA GCG 1544Asn Gly Gln Pro Leu Asn Leu Asn Thr Gly Leu Phe Glu Ser Ser Ala
485 490 495TTC GCT CAA GGC CCT CAA AAC ATG GGC GGT ATC GCA AAA AGC ATC ACT 1592Phe Ala Gln Gly Pro Gln Asn Met Gly Gly Ile Ala Lys Ser Ile Thr
500 505 510CAA GAC AGA AGC CAT TTG ATG ACA CAC ATT AGT TAT AGT TTC TAAGAGAGT 1643Gln Asp Arg Ser His Leu Met Thr His Ile Ser Tyr Ser Phe515 520 525TCTCCCCCTA TCTCTTAGAT ATGCCTTTTT GTATTTTTAT TTTA 1687
(2) Sequence 190 data:
(i) sequence characteristics:
(A) length: 528 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 190: met Lys Leu Lys Lys Arg Lys Val Ala Ala Ala Leu Leu Lys Arg Phe 151015 Thr Leu Pro Leu Leu Phe Thr Thr Gly Ser Leu Gly Ala Val Thr Tyr
20 25 30Glu Val His Gly Asp Phe Ile Asn Phe Ala Lys Val Gly Phe Asn His
35 40 45Ser Pro Ile Asn Pro Val Lys Gly Ile Tyr Pro Thr Glu Thr Phe Val
50 55 60Asn Leu Thr Gly Lys Leu Glu Gly Ser Val His Leu Gly Arg Gly Trp65 70 75 80Thr Val Asn Leu Gly Gly Val Leu Gly Gly Gln Ala Tyr Asp Gly Thr
85 90 95Lys Tyr Asp Arg Trp Ala Lys Asp Phe Thr Pro Pro Ser Tyr Trp Asp
100 105 110Lys Thr Ser Cys Gly Thr Asp Ser Met Ser Leu Cys Met Asn Ala Thr
115 120 125Lys Met Trp Gln Gln Ser Gly Pro Gly Gly Val Ile Asn Pro Arg Gly
130 135 140Ile Gly Trp Glu Tyr Met Gly Glu Trp Asn Gly Leu Phe Pro Asn Tyr145 150 155 160Tyr Pro Ala Asn Ala Tyr Leu Pro Gly Gly Ser Arg Arg Tyr Gln Val
165 170 175Tyr Lys Ala Asn Leu Thr Tyr Asp Ser Asp Arg Val His Met Val Met
180 185 190Gly Arg Phe Asp Ile Thr Glu Gln Glu Gln Met Asp Trp Ile Tyr Gln
195 200 205Leu Phe Gln Gly Phe Tyr Gly Thr Phe Lys Leu Thr Lys Asn Met Lys
210 215 220Phe Leu Leu Phe Ser Gly Trp Gly Arg Gly Ile Ala Asp Gly Gln Trp225 230 235 240Leu Phe Pro Ile Tyr Arg Glu Lys Pro Trp Gly Val His Lys Ala Gly
245 250 255Ile Ile Tyr Arg Pro Thr Lys Asn Leu Met Ile His Pro Tyr Val Tyr
260 265 270Leu Ile Pro Met Val Gly Thr Leu Pro Gly Ala Lys Ile Glu Tyr Asp
275 280 285Thr Asn Pro Glu Phe Ser Gly Arg Gly Ile Arg Asn Arg Thr Thr Phe
290 295 300Tyr Ala Leu Tyr Asp Tyr Arg Trp Asn Asn Ala Glu Tyr Gly Arg Tyr305 310 315 320Ala Pro Ala Arg Tyr Asn Thr Trp Asp Pro Phe Leu Asp Asn Gly Lys
325 330 335Trp Arg Gly Leu Gln Gly Pro Gly Gly Ala Thr Leu Leu Leu Arg His
340 345 350His Ile Asp Ile Asn Asn Tyr Phe Val Val Gly Gly Ala Tyr Leu Asn
355 360 365Ile Gly Asn Pro Asn Met Asn Leu Gly Thr Trp Gly Asn Pro Val Ala
370 375 380Val Asp Gly Ile Glu Gln Trp Val Gly Ser Ile Tyr Ser Leu Gly Phe385 390 395 400Ala Gly Ile Asp Asn Ile Thr Asp Ala Asp Ala Phe Thr Glu Tyr Val
405 410 415Lys Gly Gly Gly Lys His Gly Lys Phe Ser Trp Ser Val Tyr Gln Arg
420 425 430Phe Thr Thr Ala Pro Arg Ala Leu Glu Tyr Gly Ile Gly Met Tyr Leu
435 440 445Asp Tyr Gln Phe Ser Lys His Val Lys Ala Gly Leu Lys Leu Val Trp
450 455 460Leu Glu Phe Gln Ile Arg Ala Gly Tyr Asn Pro Gly Thr Gly Phe Leu465 470 475 480Gly Pro Asn Gly Gln Pro Leu Asn Leu Asn Thr Gly Leu Phe Glu Ser
485 490 495Ser Ala Phe Ala Gln Gly Pro Gln Asn Met Gly Gly Ile Ala Lys Ser
500 505 510Ile Thr Gln Asp Arg Ser His Leu Met Thr His Ile Ser Tyr Ser Phe
515 520 525
(2) Sequence 191 data:
(i) sequence characteristics:
(A) length: 412bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...359
(D) Other information:
(xi) Description of the sequence: sequence 191: TTTTGTCTGA TTTGTTGCTA CCAAAACCAT TACCAACCAA AGCAGATCCC ATG TTT 56
Met Phe
1TTG ATA CTA TCG AAT CCA TTC TTC AAC ACT TCT GCC ATA AAA TTC TTG 104Leu Ile Leu Ser Asn Pro Phe Phe Asn Thr Ser Ala Ile Lys Phe Leu
5 10 15ATA TTG TCC ATA GGC AAG TTG AAT TTT TTC CCT AAT ATT TCA TTA AGT 152Ile Leu Ser Ile Gly Lys Leu Asn Phe Phe Pro Asn Ile Ser Leu Ser
20 25 30CCC ATC ATT AAC ATC AGG AAG AAC AAA AAA TTT AAT ATC ATA GAA AAC 200Pro Ile Ile Asn Ile Arg Lys Asn Lys Lys Phe Asn Ile Ile Glu Asn35 40 45 50AAA TCA CTG GAT AAA CCT GTA AAA AGA TTTGTT CCG CCA CCC AAC AAA 248Lys Ser Leu Asp Lys Pro Val Lys Arg Phe Val Pro Pro Pro Asn Lys
55 60 65GAA GCT AAA ATT TTT CCC ATG ATC AGT CCT TTT ATT TTT GGT TGT GTA 296Glu Ala Lys Ile Phe Pro Met Ile Ser Pro Phe Ile Phe Gly Cys Val
70 75 80AGT TCT TGC TTG TTC GGA TCT CTA ATG CGT GTT TTA GTA GGA AGC ATT 344Ser Ser Cys Leu Phe Gly Ser Leu Met Arg Val Leu Val Gly Ser Ile
85 90 95TCA CAA TGG CAT ACC TAAAGCTACT AAGAAAATTC TTGAATCTAT TGGTAAGATT A 400Ser Gln Trp His Thr
100CTCATGAAAT CA 412
(2) Sequence 192 data:
(i) sequence characteristics:
(A) length: 103 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 192: met Phe Leu Ile Leu Ser Asn Pro Phe Phe Asn Thr Ser Ala Ile Lys 151015 Phe Leu Ile Leu Ser Ile Gly Lys Leu Asn Phe Phe Pro Asn Ile Ser
20 25 30Leu Ser Pro Ile Ile Asn Ile Arg Lys Asn Lys Lys Phe Asn Ile Ile
35 40 45Glu Asn Lys Ser Leu Asp Lys Pro Val Lys Arg Phe Val Pro Pro Pro
50 55 60Asn Lys Glu Ala Lys Ile Phe Pro Met lle Ser Pro Phe Ile Phe Gly65 70 75 80Cys Val Ser Ser Cys Leu Phe Gly Ser Leu Met Arg Val Leu Val Gly
85 90 95Ser Ile Ser Gln Trp His Thr
100
(2) Sequence 193 data:
(i) sequence characteristics:
(A) length: 447bp of DNA
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 67...405
(D) Other information:
(xi) Description of the sequence: sequence 193: TCCAATCCGT CTAATATCTC TTTATTTTCG CTCAATTCTT TAACCATAAC GGGTTTTTTA 60GCGCTT GTG GGG GTT ACT GGG CTA AAG TTT GGA GCG TTT TGC ACT TCT 108
Val Gly Val Thr Gly Leu Lys Phe Gly Ala Phe Cys Thr Ser
1 5 10TTT TCT TCT TTT TTT AGA TTT TCC TTT ATC ATT TCT TCT ATC CTT CCT 156Phe Ser Ser Phe Phe Arg Phe Ser Phe Ile Ile Ser Ser Ile Leu Pro15 20 25 30TCT ATC ATT TCT TCT TGC GTG TTT TCT TGT GGG TTT TCT TCT TTT TTA 204Ser Ile Ile Ser Ser Cys Val Phe Ser Cys Gly Phe Ser Ser Phe Leu
35 40 45GGG TGG TTG GGG GTT TTT TGG TTT TCT GTT TTG TTG TCA TTT TCT ATT 252Gly Trp Leu Gly Val Phe Trp Phe Ser Val Leu Leu Ser Phe Ser Ile
50 55 60ATG GGT GCA AGT GTG GGC ATG ATA GGT TTG GGC GTG GTG GGC GTA AGA 300Met Gly Ala SerVal Gly Met Ile Gly Leu Gly Val Val Gly Val Arg
65 70 75GTT TCT TTT GTA GGC GTG GGT TCT CTT TCT TTA GTT TCT TGT TTA ATT 348Val Ser Phe Val Gly Val Gly Ser Leu Ser Leu Val Ser Cys Leu Ile
80 85 90TCT TTT AAA GGG GGG TTA GTG GGG TTA GTC AAA TCA TCA AAT CGG TTT 396Ser Phe Lys Gly Gly Leu Val Gly Leu Val Lys Ser Ser Asn Arg Phe95 100 105 110CTT TTA GGG TAAAT GGTGTAATGG GTAGGGGGGT GGGAGGAAAT TTGGACT 447Leu Leu Gly
(2) Sequence 194 data:
(i) sequence characteristics:
(A) length: 113 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 194: val Gly Val Thr Gly Leu Lys Phe Gly Ala Phe Cys Thr Ser Phe Ser 151015 Ser Phe Phe Arg Phe Ser Phe Ile Ile Ser Ser Ile Leu Pro Ser Ile
20 25 30Ile Ser Ser Cys Val Phe Ser Cys Gly Phe Ser Ser Phe Leu Gly Trp
35 40 45Leu Gly Val Phe Trp Phe Ser Val Leu Leu Ser Phe Ser Ile Met Gly
50 55 60Ala Ser Val Gly Met Ile Gly Leu Gly Val Val Gly Val Arg Val Ser65 70 75 80Phe Val Gly Val Gly Ser Leu Ser Leu Val Ser Cys Leu Ile Ser Phe
85 90 95Lys Gly Gly Leu Val Gly Leu ValLys Ser Ser Asn Arg Phe Leu Leu
100 105 110Gly
(2) Sequence 195 data:
(i) sequence characteristics:
(A) length: 1180bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1127
(D) Other information:
(xi) Description of the sequence: sequence 195: CCAAGAAAGA GTATAATAGC GCATAAGAAT TTAACTGATG AAGAGGTTTA ATG CTA 56
Met Leu
1GAA AAT AGA GTT AAG ACC AAG CAA ATT TTT ATC GGT GGC GTG GCC ATA 104Glu Asn Arg Val Lys Thr Lys Gln Ile Phe Ile Gly Gly Val Ala Ile
5 10 15GGG GGT GAT GCT CCC ATA AGC ACG CAA AGC ATG ACC TTT AGC AAA ACC 152Gly Gly Asp Ala Pro Ile Ser Thr Gln Ser Met Thr Phe Ser Lys Thr
20 25 30GCT GAT ATT GAA AGC ACT AAA AAT CAA ATT GAC AGA CTC AAA CTC GCC 200Ala Asp Ile Glu Ser Thr Lys Asn Gln Ile Asp Arg Leu Lys Leu Ala35 40 45 50GGG GCC GAT TTA GTG AGG GTG GCG GTG AGT AAT GAA AAG GAC GCT CTA 248Gly Ala Asp Leu Val Arg Val Ala Val Ser Asn Glu Lys Asp Ala Leu
55 60 65GCC TTA AAA GAA TTG AAA AAAGTG TCC CCT TTG CCT TTA ATC GCT GAT 296Ala Leu Lys Glu Leu Lys Lys Val Ser Pro Leu Pro Leu Ile Ala Asp
70 75 80ATT CAT TTC CAT TAT AAA TTC GCT CTC ATT GCC GCT CAA AGC GTG GAT 344Ile His Phe His Tyr Lys Phe Ala Leu Ile Ala Ala Gln Ser Val Asp
85 90 95GCG ATC AGG ATT AAC CCC GGA AAC ATC GGC TCT AAA GAG AAG ATC AAA 392Ala Ile Arg Ile Asn Pro Gly Asn Ile Gly Ser Lys Glu Lys Ile Lys
100 105 110GCG GTG GTT GAT GCT TGT AAA GAA AAA AAC ATT CCT ATA AGA ATT GGC 440Ala Val Val Asp Ala Cys Lys Glu Lys Asn Ile Pro Ile Arg Ile Gly115 120 125 130GTG AAT GCT GGG AGT TTA GAA AAG CAG TTT GAT CAA AAA TAC GGA CCC 488Val Asn Ala Gly Ser Leu Glu Lys Gln Phe Asp Gln Lys Tyr Gly Pro
135 140 145ACC CCA AAA GGC ATG GTA GAA AGC GCT TTG TAT AAC GCC AAA CTT TTA 536Thr Pro Lys Gly Met Val Glu Ser Ala Leu Tyr Asn Ala Lys Leu Leu
150 155 160GAA GAT TTG GAT TTT ACC AAT TTT AAG ATT TCT TTA AAA GCG AGC GAT 584Glu Asp Leu Asp Phe Thr Asn Phe Lys Ile Ser Leu Lys Ala Ser Asp
165 170 175GTG ATT CGC ACC ATA GAA GCT TAC AGG ATG CTT CGC CCT CTT GTG ATC 632Val Ile Arg Thr Ile Glu Ala Tyr Arg Met Leu Arg Pro Leu Val Ile
180 185 190TAT CCT TTC CAT TTG GGG GTT ACG GAG GCG GGG AAT CTT TTT AGC TCC 680Tyr Pro Phe His Leu Gly Val Thr Glu Ala Gly Asn Leu Phe Ser Ser195 200 205 210AGT ATC AAA TCC GCT ATG GCT TTA GGG GGG CTT TTA ATG GAG GGC ATT 728Ser Ile Lys Ser Ala Met Ala Leu Gly Gly Leu Leu Met Glu Gly Ile
215 220 225GGG GAT ACG ATG CGC GTA TCC ATC ACA GGG GAA TTA GAA AAT GAA ATC 776Gly Asp Thr Met Arg Val Ser Ile Thr Gly Glu Leu Glu Asn Glu Ile
230 235 240AAA GTG GCC AGA GCA ATT TTA CGC CAT AGC GGG CGG TTG AAA GAA GGG 824Lys Val Ala Arg Ala Ile Leu Arg His Ser Gly Arg Leu Lys Glu Gly
245 250 255ATT AAT TGG ATT TCT TGC CCC ACT TGC GGG CGC ATT GAA GCC AAT TTA 872Ile Asn Trp Ile Ser Cys Pro Thr Cys Gly Arg Ile Glu Ala Asn Leu
260 265 270GTG GAT ATG GCG ATC AAG GTA GAA AAA CGC TTA AGC CAC ATC AAA ACC 920Val Asp Met Ala Ile Lys Val Glu Lys Arg Leu Ser His Ile Lys Thr275 280 285 290CCT TTA GAC ATT AGC GTG ATG GGT TGC GTG GTG AAT GCT TTG GGT GAA 968Pro Leu Asp Ile Ser Val Met Gly Cys Val Val Asn Ala Leu Gly Glu
295 300 305GCC AAG CAT GCA GAC ATG GCG ATC GCT TTT GGG AAT CGC AGC GGT TTG 1016Ala Lys His Ala Asp Met Ala Ile Ala Phe Gly Asn Arg Ser Gly Leu
310 315 320ATC ATT AAA GAG GGT AAA GTC ATT CAC AAA CTG GCT GAA AAG GAT TTA 1064Ile Ile Lys Glu Gly Lys Val Ile His Lys Leu Ala Glu Lys Asp Leu
325 330 335TTT GAA ACT TTT GTG ATA GAA GTG GAA AAT TTA GCT AAA GAA AGA GAA 1112Phe Glu Thr Phe Val Ile Glu Val Glu Asn Leu Ala Lys Glu Arg Glu
340 345 350AAA AGT TTA AAG GAT TAGGCATGAT CAATAAGTTT AAAAATTTTG TGAGCAACTA C 1168Lys Ser Leu Lys Asp355CAGCAATCTA AC 1180
(2) Sequence 196 data:
(i) sequence characteristics:
(A) length: 359 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 196: met Leu Glu Asn Arg Val Lys Thr Lys Gln Ile Phe Ile Gly Gly Val 151015 Ala Ile Gly Gly Asp Ala Pro Ile Ser Thr Gln Ser Met Thr Phe Ser
20 25 30Lys Thr Ala Asp Ile Glu Ser Thr Lys Asn Gln Ile Asp Arg Leu Lys
35 40 45Leu Ala Gly Ala Asp Leu Val Arg Val Ala Val Ser Asn Glu Lys Asp
50 55 60Ala Leu Ala Leu Lys Glu Leu Lys Lys Val Ser Pro Leu Pro Leu Ile65 70 75 80Ala Asp Ile His Phe His Tyr Lys Phe Ala Leu Ile Ala Ala Gln Ser
85 90 95Val Asp Ala Ile Arg Ile Asn Pro Gly Asn Ile Gly Ser Lys Glu Lys
100 105 110Ile Lys Ala Val Val Asp Ala Cys Lys Glu Lys Asn Ile Pro Ile Arg
115 120 125Ile Gly Val Asn Ala Gly Ser Leu Glu Lys Gln Phe Asp Gln Lys Tyr
130 135 140Gly Pro Thr Pro Lys Gly Met Val Glu Ser Ala Leu Tyr Asn Ala Lys145 150 155 160Leu Leu Glu Asp Leu Asp Phe Thr Asn Phe Lys Ile Ser Leu Lys Ala
165170 175Ser Asp Val Ile Arg Thr Ile Glu Ala Tyr Arg Met Leu Arg Pro Leu
180 185 190Val Ile Tyr Pro Phe His Leu Gly Val Thr Glu Ala Gly Asn Leu Phe
195 200 205Ser Ser Ser Ile Lys Ser Ala Met Ala Leu Gly Gly Leu Leu Met Glu
210 215 220Gly Ile Gly Asp Thr Met Arg Val Ser Ile Thr Gly Glu Leu Glu Asn225 230 235 240Glu Ile Lys Val Ala Arg Ala Ile Leu Arg His Ser Gly Arg Leu Lys
245 250 255Glu Gly Ile Asn Trp Ile Ser Cys Pro Thr Cys Gly Arg Ile Glu Ala
260 265 270Asn Leu Val Asp Met Ala Ile Lys Val Glu Lys Arg Leu Ser His Ile
275 280 285Lys Thr Pro Leu Asp Ile Ser Val Met Gly Cys Val Val Asn Ala Leu
290 295 300Gly Glu Ala Lys His Ala Asp Met Ala Ile Ala Phe Gly Asn Arg Ser305 310 315 320Gly Leu Ile Ile Lys Glu Gly Lys Val Ile His Lys Leu Ala Glu Lys
325 330 335Asp Leu Phe Glu Thr Phe Val Ile Glu Val Glu Asn Leu Ala Lys Glu
340 345 350Arg Glu Lys Ser Leu Lys Asp
355
(2) Sequence 197 data:
(i) sequence characteristics:
(A) length: 1399bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1346
(D) Other information:
(xi) Description of the sequence: sequence 197: GCCTATGAAA TCTTAAAGCG TTATCCGGCT AAAGCAAAGG TATAAATAAC ATG AAA 56
Met Lys
1AAA TTT TTA ATC ACT TTA TTA TTA GGA GTT TTT ATG GGG TTA CAA GCG 104Lys Phe Leu Ile Thr Leu Leu Leu Gly Val Phe Met Gly Leu Gln Ala
5 10 15AGC GCT TTG ACA CAC CAA GAA ATC AAT CAA GCT AAA GTC CCT GTG ATT 152Ser Ala Leu Thr His Gln Glu Ile Asn Gln Ala Lys Val Pro Val Ile
20 25 30TAT GAA GAA AAC CAT TTG TTG CCT ATG GGG TTT ATC CAT TTA GCC TTT 200Tyr Glu Glu Asn His Leu Leu Pro Met Gly Phe Ile His Leu Ala Phe35 40 45 50AGG GGG GGT GGG AGC TTA AGC GAT AAA AAC CAG TTG GGT TTG GCG AAA 248Arg Gly Gly Gly Ser Leu Ser Asp Lys Asn Gln Leu Gly Leu Ala Lys
55 60 65TTA TTC GCG CAA GTT TTA AAC GAA GGC ACT AAA GAG CTT GGT GCG GTG 296Leu Phe Ala Gln Val Leu Asn Glu Gly Thr Lys Glu Leu Gly Ala Val
70 75 80GGG TTT GCG CAA CTT TTA GAG CAA AAA GCG ATC AGT TTG AAT GTG GAT 344Gly Phe Ala Gln Leu Leu Glu Gln Lys Ala Ile Ser Leu Asn Val Asp
85 90 95ACC AGC ACA GAA GAT TTG CAA ATC ACT TTA GAA TTT TTAAAA GAA TAC 392Thr Ser Thr Glu Asp Leu Gln Ile Thr Leu Glu Phe Leu Lys Glu Tyr
100 105 110GAA GAT GAA GCC ATT ACG CGC TTA AAA GAG CTT TTA AAA TCC CCT AAT 440Glu Asp Glu Ala Ile Thr Arg Leu Lys Glu Leu Leu Lys Ser Pro Asn115 120 125 130TTC ACG CAA AAC GCT TTA GAA AAA GTC AAA ACC CAA ATG TTA GCC GCA 488Phe Thr Gln Asn Ala Leu Glu Lys Val Lys Thr Gln Met Leu Ala Ala
135 140 145CTT TTA CAA AAA GAA AGC GAT TTT GAC TAT TTG GCT AAA TTG ACT TTA 536Leu Leu Gln Lys Glu Ser Asp Phe Asp Tyr Leu Ala Lys Leu Thr Leu
150 155 160AAG CAA GAG CTT TTT GCT AAC ACC CCT TTA GCT AAC GCA GCC TTA GGC 584Lys Gln Glu Leu Phe Ala Asn Thr Pro Leu Ala Asn Ala Ala Leu Gly
165 170 175ACT AAA GAG AGC ATT CAA AAA ATC AAG CTA GAC GAT TTG AAA CAG CAA 632Thr Lys Glu Ser Ile Gln Lys Ile Lys Leu Asp Asp Leu Lys Gln Gln
180 185 190TTT GCT AAG GTC TTT GAA CTC AAT AAG CTC GTG GTG GTG CTT GGG GGC 680Phe Ala Lys Val Phe Glu Leu Asn Lys Leu Val Val Val Leu Gly Gly195 200 205 210GAT TTG AAA ATC GAT CAA ACC CTT AAG CGT TTG AAT AAC GCC CTT AAT 728Asp Leu Lys Ile Asp Gln Thr Leu Lys Arg Leu Asn Asn Ala Leu Asn
215 220 225TTC TTG CCA CAA GGT AAA GCG TAT GAA GAG CCT TAT TTT GAA ACG AGC 776Phe Leu Pro Gln Gly Lys Ala Tyr Glu Glu Pro Tyr Phe Glu Thr Ser
230 235 240GAT AAA AAA AGC GAA AAA GTC CTC TAT AAA GAC ACT GAG CAG GCT TTC 824Asp Lys Lys Ser Glu Lys Val Leu Tyr Lys Asp Thr Glu Gln Ala Phe
245 250 255GTG TAT TTT GGT GCG CCC TTT AAA ATC AAG GAT TTA AAA CAG GAT TTA 872Val Tyr Phe Gly Ala Pro Phe Lys Ile Lys Asp Leu Lys Gln Asp Leu
260 265 270GCG AAA TCT AAA GTC ATG ATG TTT GTG CTT GGT GGG GGG TTT GGC TCT 920Ala Lys Ser Lys Val Met Met Phe Val Leu Gly Gly Gly Phe Gly Ser275 280 285 290CGT TTA ATG GAA AAA ATC AGG GTT CAA GAG GGA TTA GCT TAT AGC GTG 968Arg Leu Met Glu Lys Ile Arg Val Gln Glu Gly Leu Ala Tyr Ser Val
295 300 305TAT ATC CGC TCC AAT TTT TCT AAA GTG GCG CAT TTT GCG AGC GGG TAT 1016Tyr Ile Arg Ser Asn Phe Ser Lys Val Ala His Phe Ala Ser Gly Tyr
310 315 320TTG CAA ACC AAG CTC AGC ACT CAA ACT AAA AGC GTT GCC TTA GTT AAA 1064Leu Gln Thr Lys Leu Ser Thr Gln Thr Lys Ser Val Ala Leu Val Lys
325 330 335AAA ATC GTT AAG GAA TTT ATA GAA AAA GGC ATG ACG CAA CAA GAA TTA 1112Lys Ile Val Lys Glu Phe Ile Glu Lys Gly Met Thr Gln Gln Glu Leu
340 345 350GAC GAC GCT AAA AAG TTT TTA CTA GGC TCT GAG CCT TTA AGG AAT GAA 1160Asp Asp Ala Lys Lys Phe Leu Leu Gly Ser Glu Pro Leu Arg Asn Glu355 360 365 370ACG ATC TCT AGC CGC TTG AAC ACC ACT TAC AAT TAT TTT TAT TTA GGT 1208Thr Ile Ser Ser Arg Leu Asn Thr Thr Tyr Asn Tyr Phe Tyr Leu Gly
375 380 385TTG CCT TTA AAT TTT AAC CAA ACG CTG CTC AAT CAA ATC CAA AAA ATG 1256Leu Pro Leu Asn Phe Asn Gln Thr Leu Leu Asn Gln Ile Gln Lys Met
390 395 400AGT TTG AAA GAA ATC AAT GAT TTC ATT AAA GCC CACACC GAA ATC AAC 1304Ser Leu Lys Glu Ile Asn Asp Phe Ile Lys Ala His Thr Glu Ile Asn
405 410 415GAC TTG ACT TTT GCT ATT GTG AGC AAT AAA AAG AAG GAC AAA TGATGCCAT 1355Asp Leu Thr Phe Ala Ile Val Ser Asn Lys Lys Lys Asp Lys
420 425 430TTGAAGCTGT AATCGGGCTA GAAGTCCATG TCCAACTCAA CACC 1399
(2) Sequence 198 data:
(i) sequence characteristics:
(A) length: 432 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 198: met Lys Lys Phe Leu Ile Thr Leu Leu Leu Gly Val Phe Met Gly Leu 151015 Gln Ala Ser Ala Leu Thr His Gln Glu Ile Asn Gln Ala Lys Val Pro
20 25 30Val Ile Tyr Glu Glu Asn His Leu Leu Pro Met Gly Phe Ile His Leu
35 40 45Ala Phe Arg Gly Gly Gly Ser Leu Ser Asp Lys Asn Gln Leu Gly Leu
50 55 60Ala Lys Leu Phe Ala Gln Val Leu Asn Glu Gly Thr Lys Glu Leu Gly65 70 75 80Ala Val Gly Phe Ala Gln Leu Leu Glu Gln Lys Ala Ile Ser Leu Asn
85 90 95Val Asp Thr Ser Thr Glu Asp Leu Gln Ile Thr Leu Glu Phe Leu Lys
100 105 110Glu Tyr Glu Asp Glu Ala Ile Thr Arg Leu Lys Glu Leu Leu Lys Ser
115 120 125Pro Asn Phe Thr Gln Asn Ala Leu Glu Lys Val Lys Thr Gln Met Leu
130 135 140Ala Ala Leu Leu Gln Lys Glu Ser Asp Phe Asp Tyr Leu Ala Lys Leu145 150 155 160Thr Leu Lys Gln Glu Leu Phe Ala Asn Thr Pro Leu Ala Asn Ala Ala
165 170 175Leu Gly Thr Lys Glu Ser Ile Gln Lys Ile Lys Leu Asp Asp Leu Lys
180 185 190Gln Gln Phe Ala Lys Val Phe Glu Leu Asn Lys Leu Val Val Val Leu
195 200 205Gly Gly Asp Leu Lys Ile Asp Gln Thr Leu Lys Arg Leu Asn Asn Ala
210 215 220Leu Asn Phe Leu Pro Gln Gly Lys Ala Tyr Glu Glu Pro Tyr Phe Glu225 230 235 240Thr Ser Asp Lys Lys Ser Glu Lys Val Leu Tyr Lys Asp Thr Glu Gln
245 250 255Ala Phe Val Tyr Phe Gly Ala Pro Phe Lys Ile Lys Asp Leu Lys Gln
260 265 270Asp Leu Ala Lys Ser Lys Val Met Met Phe Val Leu Gly Gly Gly Phe
275 280 285Gly Ser Arg Leu Met Glu Lys Ile Arg Val Gln Glu Gly Leu Ala Tyr
290 295 300Ser Val Tyr Ile Arg Ser Asn Phe Ser Lys Val Ala His Phe Ala Ser305 310 315 320Gly Tyr Leu Gln Thr Lys Leu Ser Thr Gln Thr Lys Ser Val Ala Leu
325 330 335Val Lys Lys Ile Val Lys Glu Phe Ile Glu Lys Gly Met ThrGln Gln
340 345 350Glu Leu Asp Asp Ala Lys Lys Phe Leu Leu Gly Ser Glu Pro Leu Arg
355 360 365Asn Glu Thr Ile Ser Ser Arg Leu Asn Thr Thr Tyr Asn Tyr Phe Tyr
370 375 380Leu Gly Leu Pro Leu Asn Phe Asn Gln Thr Leu Leu Asn Gln Ile Gln385 390 395 400Lys Met Ser Leu Lys Glu Ile Asn Asp Phs Ile Lys Ala His Thr Glu
405 410 415Ile Asn Asp Leu Thr Phe Ala Ile Val Ser Asn Lys Lys Lys Asp Lys
420 425 430
(2) Sequence 199 data:
(i) sequence characteristics:
(A) length: 574bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...521
(D) Other information:
(xi) Description of the sequence: sequence 199: GAAGAGCCAG AAAATTTAGA AACCTCTTCG GCACAAAATT TGTTTGAGTG ATG CGT 56
Met Arg
1TTC TTT TCA TTC TTT TAT TTT TTA TTT TAT TTT TTA GGG GTT TCT TTG 104Phe Phe Ser Phe Phe Tyr Phe Leu Phe Tyr Phe Leu Gly Val Ser Leu
510 15CAA GCT CTC AGC CCC CTA GAA GAT CAA GAA TTT TTA ATT TCG TAC CGC 152Gln Ala Leu Ser Pro Leu Glu Asp Gln Glu Phe Leu Ile Ser Tyr Arg
20 25 30TTG AAA ATC GTT GAT TCT AGA GTG ATG GGC GAA GAG TAT TCT GTC TCT 200Leu Lys Ile Val Asp Ser Arg Val Met Gly Glu Glu Tyr Ser Val Ser35 40 45 50AAA CCT ATC GTT AGC CGC ATT AAA ACA GCC CCC TAT GTT TTA GAC TAT 248Lys Pro Ile Val Ser Arg Ile Lys Thr Ala Pro Tyr Val Leu Asp Tyr
55 60 65CAT TGC TCC ATC ATC ACT CGT AAC TTA CCC AAT TTG AAA AAC CCC TTG 296His Cys Ser Ile Ile Thr Arg Asn Leu Pro Asn Leu Lys Asn Pro Leu
70 75 80CTC CCA ATA AAG TTA GAA CGC TTC CTT TTA GAA ATC GCG TTA AAA AAA 344Leu Pro Ile Lys Leu Glu Arg Phe Leu Leu Glu Ile Ala Leu Lys Lys
85 90 95GAA AAA GAG CGG GTC ATA GAC TGC ATT TTA AAA AGC CAG GTC GCT ATC 392Glu Lys Glu Arg Val Ile Asp Cys Ile Leu Lys Ser Gln Val Ala Ile
100 105 110ACG CAT TAT GAT CAT AGC TAT AAA AAC GGC ACC ACT ACC ACA AGC ATT 440Thr His Tyr Asp His Ser Tyr Lys Asn Gly Thr Thr Thr Thr Ser Ile115 120 125 130CTT GCC CTC AAA GCC TTA AGC GTT AGA GCG AGT TTA GTG GGA GAT GCG 488Leu Ala Leu Lys Ala Leu Ser Val Arg Ala Sar Leu Val Gly Asp Ala
135 140 145CTG TTT TTA GAT ATT TTT AGA AAG GAA GAA GAA TGAAAATCGC CATTGTAGAA 541Leu Phe Leu Asp Ile Phe Arg Lys Glu Glu Glu
150 155GATGATATTA ACATGCGTAA AAGCCTGGAG CTT 574
(2) Sequence 200 data:
(i) sequence characteristics:
(A) length: 157 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 200: met Arg Phe Phe Ser Phe Phe Tyr Phe Leu Phe Tyr Phe Leu Gly Val 151015 Ser Leu Gln Ala Leu Ser Pro Leu Glu Asp Gln Glu Phe Leu Ile Ser
20 25 30Tyr Arg Leu Lys Ile Val Asp Ser Arg Val Met Gly Glu Glu Tyr Ser
35 40 45Val Ser Lys Pro Ile Val Ser Arg Ile Lys Thr Ala Pro Tyr Val Leu
50 55 60Asp Tyr His Cys Ser Ile Ile Thr Arg Asn Leu Pro Asn Leu Lys Asn65 70 75 80Pro Leu Leu Pro Ile Lys Leu Glu Arg Phe Leu Leu Glu Ile Ala Leu
85 90 95Lys Lys Glu Lys Glu Arg Val Ile Asp Cys Ile Leu Lys Ser Gln Val
100 105 110Ala Ile Thr His Tyr Asp His Ser Tyr Lys Asn Gly Thr Thr Thr Thr
115 120 125Ser Ile Leu Ala Leu Lys Ala Leu Ser Val Arg Ala Ser Leu Val Gly
130 135 140Asp Ala Leu Phe Leu Asp Ile Phe Arg Lys Glu Glu Glu145 150 155
(2) Sequence 201 data:
(i) sequence characteristics:
(A) length: 1003bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...950
(D) Other information:
(xi) Description of the sequence: sequence 20 l: ATCATGAGAA AACGCTTCAC TCCACTTTTG TTATTCAGGA AATAATACAG ATG AGA 56
Met Arg
1AAA ACG ATT TCA GCG TTG TTT TTA TCA GCG TGC ATA GGG TTA TCG TCT 104Lys Thr Ile Ser Ala Leu Phe Leu Ser Ala Cys Ile Gly Leu Ser Ser
5 10 15GTT TAT GCA GAT AAC GCT TTG ATT TTG CAA ACC GAT TTT AGT CTA AAA 152Val Tyr Ala Asp Asn Ala Leu Ile Leu Gln Thr Asp Phe Ser Leu Lys
20 25 30GAT GGG GCC GTC TCG GCG ATG AAA GGC GTC GCT TTC AGC GTT GAT TCC 200Asp Gly Ala Val Ser Ala Met Lys Gly Val Ala Phe Ser Val Asp Ser35 40 45 50CAT CTT AAA ATC TTT GAT TTA ACG CAC GAA ATC CCC CCG TAT AAC ATC 248His Leu Lys Ile Phe Asp Leu Thr His Glu Ile Pro Pro Tyr Asn Ile
55 60 65TGG GAA GGC GCT TAC CGC TTG TAT CAG ACC GCC AGT TAT TGG CCA AAA 296Trp Glu Gly Ala Tyr Arg Leu Tyr Gln Thr Ala Ser Tyr Trp Pro Lys
70 75 80GGT TCG GTA TTT GTG AGC GTA GTT GAT CCG GGC GTA GGC ACT AAG CGT 344Gly Ser Val Phe Val Ser Val Val Asp Pro Gly Val Gly Thr Lys Arg
85 90 95AAA TCG GTG GTA CTA AAA ACT AAA AAC GGC CAG TAT TTC GTC TCG CCG 392Lys Ser Val Val Leu Lys Thr Lys Asn Gly Gln Tyr Phe Val Ser Pro
100 105 110GAT AAC GGC ACG CTG ACT TTG GTG GCA CAA ACT TTG GGG ATT GAT AGC 440Asp Asn Gly Thr Leu Thr Leu Val Ala Gln Thr Leu Gly Ile Asp Ser115 120 125 130GTG CGT GAA ATT GAT GAA AAA GCT AAC CGC TTG AAA GGT TCT GAA AAA 488Val Arg Glu Ile Asp Glu Lys Ala Asn Arg Leu Lys Gly Ser Glu Lys
135 140 145TCC TAT ACT TTC CAT GGT CGT GAT GTG TAT GCT TAC ACC GGT GCA CGC 536Ser Tyr Thr Phe His Gly Arg Asp Val Tyr Ala Tyr Thr Gly Ala Arg
150 155 160TTG GCT TCT GGG GCG ATC ACA TTC GAG CAG GTC GGG CCA GAG CTT CCC 584Leu Ala Ser Gly Ala Ile Thr Phe Glu Gln Val Gly Pro Glu Leu Pro
165 170 175CCA AAA GTC GTT GAA ATT CCT TAC CAA AAA GCG AAA GCC ACA AAA GGG 632Pro Lys Val Val Glu Ile Pro Tyr Gln Lys Ala Lys Ala Thr Lys Gly
180 185 190GAA GTG AAA GGT AAT ATC CCG ATT TTG GAT ATT CAA TAT GGC AAT GTT 680Glu Val Lys Gly Asn Ile Pro Ile Leu Asp Ile Gln Tyr Gly Asn Val195 200 205 210TGG AGC AAC ATC AGC GAT AAA TTA CTC AAT CAA GCA AAA ATC AAA CTC 728Trp Ser Asn Ile Ser Asp Lys Leu Leu Asn Gln Ala Lys Ile Lys Leu
215 220 225AAT GAC ACG CTG TGT GTA ACG ATT TTT AAA GGT TCT AAG AAA CAA TAC 776Asn Asp Thr Leu Cys Val Thr Ile Phe Lys Gly Ser Lys Lys Gln Tyr
230 235 240GAA GGG AAA ATG CCG TAT GTC GCA AGC TTT GGC GAT GTG CCA GAA GGC 824Glu Gly Lys Met Pro Tyr Val Ala Ser Phe Gly Asp Val Pro Glu Gly
245 250 255CAG CCG TTA GTT TAT TTA AAC AGC TTG TTA AAT GTT TCC GTG GCG CTG 872Gln Pro Leu Val Tyr Leu Asn Ser Leu Leu Asn Val Ser Val Ala Leu
260 265 270AAT AGG GAT AAT TTC GCG CAA AAA TAT CAA ATC AAA TCC GGT GCT GAC 920Asn Arg Asp Asn Phe Ala Gln Lys Tyr Gln Ile Lys Ser Gly Ala Asp275 280 285 290TGG AAT ATT GAT ATA AAG AAG TGC GCT AAG TAAAGCGCTG TTTAGAAAAT TAA 973Trp Asn Ile Asp Ile Lys Lys Cys Ala Lys
295 300GGGGCGTGAA ACGCCCTAAC CGCTAAAGAT 1003
(2) Sequence 202 data:
(i) sequence characteristics:
(A) length: 300 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 202: met Arg Lys Thr Ile Ser Ala Leu Phe Leu Ser Ala Cys Ile Gly Leu 151015 Ser Ser Val Tyr Ala Asp Asn Ala Leu Ile Leu Gln Thr Asp Phe Ser
20 25 30Leu Lys Asp Gly Ala Val Ser Ala Met Lys Gly Val Ala Phe Ser Val
35 40 45Asp Ser His Leu Lys Ile Phe Asp Leu Thr His Glu Ile Pro Pro Tyr
50 55 60Asn Ile Trp Glu Gly Ala Tyr Arg Leu Tyr Gln Thr Ala SerTyr Trp65 70 75 80Pro Lys Gly Ser Val Phe Val Ser Val Val Asp Pro Gly Val Gly Thr
85 90 95Lys Arg Lys Ser Val Val Leu Lys Thr Lys Asn Gly Gln Tyr Phe Val
100 105 110Ser Pro Asp Asn Gly Thr Leu Thr Leu Val Ala Gln Thr Leu Gly Ile
115 120 125Asp Ser Val Arg Glu Ile Asp Glu Lys Ala Asn Arg Leu Lys Gly Ser
130 135 140Glu Lys Ser Tyr Thr Phe His Gly Arg Asp Val Tyr Ala Tyr Thr Gly145 150 155 160Ala Arg Leu Ala Ser Gly Ala Ile Thr Phe Glu Gln Val Gly Pro Glu
165 170 175Leu Pro Pro Lys Val Val Glu Ile Pro Tyr Gln Lys Ala Lys Ala Thr
180 185 190Lys Gly Glu Val Lys Gly Asn Ile Pro Ile Leu Asp Ile Gln Tyr Gly
195 200 205Asn Val Trp Ser Asn Ile Ser Asp Lys Leu Leu Asn Gln Ala Lys Ile
210 215 220Lys Leu Asn Asp Thr Leu Cys Val Thr Ile Phe Lys Gly Ser Lys Lys225 230 235 240Gln Tyr Glu Gly Lys Met Pro Tyr Val Ala Ser Phe Gly Asp Val Pro
245 250 255Glu Gly Gln Pro Leu Val Tyr Leu Asn Ser Leu Leu Asn Val Ser Val
260 265 270Ala Leu Asn Arg Asp Asn Phe Ala Gln Lys Tyr Gln Ile Lys Ser Gly
275 280 285Ala Asp Trp Asn Ile Asp Ile Lys Lys Cys Ala Lys
290 295 300
(2) Sequence 203 data:
(i) sequence characteristics:
(A) length: 1213bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1160
(D) Other information:
(xi) Description of the sequence: sequence 203: ATTATTTTTA ATCTTGCATG AAATCTTAAA TATAGAATTA GTCCCTTTGG ATG GGA 56
Met Gly
1TTT TCN CTC GCG CTA GGC TAT TTG TGT TTG TTT ATA TTC GTT TTA AGC 104Phe Xaa Leu Ala Leu Gly Tyr Leu Cys Leu Phe Ile Phe Val Leu Ser
5 10 15GCT TCT TTA ATC TCT GAA AAA GCC TTA TCC AAG CAG TAT TTG CAA ACC 152Ala Ser Leu Ile Ser Glu Lys Ala Leu Ser Lys Gln Tyr Leu Gln Thr
20 25 30GCT AAA GAT AAA ATC ACC TCT TTA AAG AAT TTA AAA GTC ATC GCC ATT 200Ala Lys Asp Lys Ile Thr Ser Leu Lys Asn Leu Lys Val Ile Ala Ile35 40 45 50ACC GGA AGC TTT GGG AAA ACC AGC ACC AAA AAT TTC TTG CTT CAA ATC 248Thr Gly Ser Phe Gly Lys Thr Ser Thr Lys Asn Phe Leu Leu Gln Ile
55 60 65TTA CAA ACC ACA TTC AAC GCG CAT GCA AGC CCC AAA AGC GTC AAT ACC 296Leu Gln Thr Thr Phe Asn Ala His Ala Ser Pro Lys Ser Val Asn Thr
70 75 80CTT TTA GGG CTT GCG AAT GAT ATT AAT CAG AAT TTA GAC GAT AGG AGT 344Leu Leu Gly Leu Ala Asn Asp Ile Asn Gln Asn Leu Asp Asp Arg Ser
85 90 95GAA ATC TAT ATC GCT GAA GCC GGG GCA AGG AAT AAG GGC GAT ATT AAA 392Glu Ile Tyr Ile Ala Glu Ala Gly Ala Arg Asn Lys Gly Asp Ile Lys
100 105 110GAA ATC ACC TGT CTC ATT GAA CCG CAC CTT GTT GTG GTT GCA GAA GTG 440Glu Ile Thr Cys Leu Ile Glu Pro His Leu Val Val Val Ala Glu Val115 120 125 130GGC GAA CAG CAT TTA GAA TAC TTT AAA ACT TTA GAA AAT ATT TGC GAG 488Gly Glu Gln His Leu Glu Tyr Phe Lys Thr Leu Glu Asn Ile Cys Glu
135 140 145ACT AAA GCG GAA TTA TTG GAT TCC AAA CGC TTA GAA AAA GCC TTT TGT 536Thr Lys Ala Glu Leu Leu Asp Ser Lys Arg Leu Glu Lys Ala Phe Cys
150 155 160TAC TCG GTG GAA AAG ATC AAG CCC TAT GCC CCT AAA GAT AGC CCT TTA 584Tyr Ser Val Glu Lys Ile Lys Pro Tyr Ala Pro Lys Asp Ser Pro Leu
165 170 175ATA GAC TAT TCT AGC CTG GTT AAA AAC ATC CAA TCC ACT TTA AAA GGC 632Ile Asp Tyr Ser Ser Leu Val Lys Asn Ile Gln Ser Thr Leu Lys Gly
180 185 190ACT TCT TIT GAA ATG CTT ATA GGT AGC GTT TGG GAA AGA TTT GAA ACA 680Thr Ser Phe Glu Met Leu Ile Gly Ser Val Trp Glu Arg Phe Glu Thr195 200 205 210AAG GTT CTA GGG GAG TTT AGC GCT TAT AAT ATC GCT TCA GCC ATT TTA 728Lys Val Leu Gly Glu Phe Ser Ala Tyr Asn Ile Ala Ser Ala Ile Leu
215 220 225ATC GCT AAG CAT TTA GGC TTA GAG ACC GAA AGG ATC AAA CGG CTT GTT 776Ile Ala Lys His Leu Gly Leu Glu Thr Glu Arg Ile Lys Arg Leu Val
230 235 240TTA GAA CTC AAC CCT ATT GCT CAT CGT TTG CAA CTT TTG GAA GTG AAT 824Leu Glu Leu Asn Pro Ile Ala His Arg Leu Gln Leu Leu Glu Val Asn
245 250 255CAA AAA ATC ATC ATA GAC GAT AGC TTT AAT GGG AAT TTA AAG GGC ATG 872Gln Lys Ile Ile Ile Asp Asp Ser Phe Asn Gly Asn Leu Lys Gly Met
260 265 270TTA GAG GGC ATT CGT TTA GCG AGT TTG CAC AAA GGG CGT AAA GTC ATT 920Leu Glu Gly Ile Arg Leu Ala Ser Leu His Lys Gly Arg Lys Val Ile275 280 285 290GTA ACA CCG GGC TTA GTG GAA AGC AAT ACA GAA AGT AAT GAG GCT TTA 968Val Thr Pro Gly Leu Val Glu Ser Asn Thr Glu Ser Asn Glu Ala Leu
295 300 305GCG CAA AAA ATA GAC GGG GTT TTT GAT GTC GCT ATC ATC ACA GGG GAG 1016Ala Gln Lys Ile Asp Gly Val Phe Asp Val Ala Ile Ile Thr Gly Glu
310 315 320TTG AAT TCC AAA ACG ATT GCT TCA CAA TTG AAA ACC CCC CAA AAA ATC 1064Leu Asn Ser Lys Thr Ile Ala Ser Gln Leu Lys Thr Pro Gln Lys Ile
325 330 335TTA CTC AAG GAT AAG GCG CAA TTG GAA AAT ATC TTA CAA GCC ACC ACG 1112Leu Leu Lys Asp Lys Ala Gln Leu Glu Asn Ile Leu Gln Ala Thr Thr
340 345 350ATT CAA GGC GAT TTG ATT TTA TTC GCT AAT GAC GCC CCT AAT TAC ATT T 1161Ile Gln Gly Asp Leu Ile Leu Phe Ala Asn Asp Ala Pro Asn Tyr Ile355 360 365 370AGGAAATGAA CATGCAACAT TTATACGCTC CTTGGCGCGA AAGTTATTTG AA 1213
(2) Sequence 204 data:
(i) sequence characteristics:
(A) length: 370 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 204: met Gly Phe Xaa Leu Ala Leu Gly Tyr Leu Cys Leu Phe Ile Phe Val 151015 Leu Ser Ala Ser Leu Ile Ser Glu Lys Ala Leu Ser Lys Gln Tyr Leu
20 25 30Gln Thr Ala Lys Asp Lys Ile Thr Ser Leu Lys Asn Leu Lys Val Ile
35 40 45Ala Ile Thr Gly Ser Phe Gly Lys Thr Ser Thr Lys Asn Phe Leu Leu
50 55 60Gln Ile Leu Gln Thr Thr Phe Asn Ala His Ala Ser Pro Lys Ser Val65 70 75 80Asn Thr Leu Leu Gly Leu Ala Asn Asp Ile Asn Gln Asn Leu Asp Asp
85 90 95Arg Ser Glu Ile Tyr Ile Ala Glu Ala Gly Ala Arg Asn Lys Gly Asp
100 105 110Ile Lys Glu Ile Thr Cys Leu Ile Glu Pro His Leu Val Val Val Ala
115 120 125Glu Val Gly Glu Gln His Leu Glu Tyr Phe Lys Thr Leu Glu Asn Ile
130 135 140Cys Glu Thr Lys Ala Glu Leu Leu Asp Ser Lys Arg Leu Glu Lys Ala145 150 155 160Phe Cys Tyr Ser Val Glu Lys Ile Lys Pro Tyr Ala Pro Lys Asp Ser
165 170 175Pro Leu Ile Asp Tyr Ser Ser Leu Val Lys Asn Ile Gln Ser Thr Leu
180 185 190Lys Gly Thr Ser Phe Glu Met Leu Ile Gly Ser Val Trp Glu Arg Phe
195 200 205Glu Thr Lys Val Leu Gly Glu Phe Ser Ala Tyr Asn Ile Ala Ser Ala
210 215 220Ile Leu Ile Ala Lys His Leu Gly Leu Glu Thr Glu Arg Ile Lys Arg225 230 235 240Leu Val Leu Glu Leu Asn Pro Ile Ala His Arg Leu Gln Leu Leu Glu
245 250 255Val Asn Gln Lys Ile Ile Ile Asp Asp Ser Phe Asn Gly Asn Leu Lys
260 265 270Gly Met Leu Glu Gly Ile Arg Leu Ala Ser Leu His Lys Gly Arg Lys
275 280 285Val Ile Val Thr Pro Gly Leu Val Glu Ser Asn Thr Glu Ser Asn Glu
290 295 300Ala Leu Ala Gln Lys Ile Asp Gly Val Phe Asp Val Ala Ile Ile Thr305 310 315 320Gly Glu Leu Asn Ser Lys Thr Ile Ala Ser Gln Leu Lys Thr Pro Gln
325 330 335Lys Ile Leu Leu Lys Asp Lys Ala Gln Leu Glu Asn Ile Leu Gln Ala
340 345 350Thr Thr Ile Gln Gly Asp Leu Ile Leu Phe Ala Asn Asp Ala Pro Asn
355 360 365Tyr Ile
370
(2) Sequence 205 data:
(i) sequence characteristics:
(A) length: 1303bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1250
(D) Other information:
(xi) Description of the sequence: sequence 205: CCTTGTGGTC TCATTTGTTT CTGTTTTACT TGTAGCTTGG AGGACTAGGC ATG TAT 56
Met Tyr
1AAA TTA GGG GTG TTT TTG TTA GCC ACC TTA CTA TCA GCT AAC ACG CAA 104Lys Leu Gly Val Phe Leu Leu Ala Thr Leu Leu Ser Ala Asn Thr Gln
5 10 15AAA GTG AGC GAT ATT GCT AAA GAT ATC CAA CAT AAA GAA ACC CTT TTG 152Lys Val Ser Asp Ile Ala Lys Asp Ile Gln His Lys Glu Thr Leu Leu
20 25 30AAA AAA ACC CAT GAA GAA AAA AAC CAA CTA AAC AGC CGT TTG AGT TCT 200Lys Lys Thr His Glu Glu Lys Asn Gln Leu Asn Ser Arg Leu Ser Ser35 40 45 50TTA GGC GAA GCG ATC CGC TCT AAA GAG GTT CAA AAG GCT GAG ATG GAG 248Leu Gly Glu Ala Ile Arg Ser Lys Glu Leu Gln Lys Ala Glu Met Glu
55 60 65CGC CAA ATG ATC GCT TTA AAA AAG AGT CTT GAA AAA AAT CGT AAC GAA 296Arg Gln Met Ile Ala Leu Lys Lys Ser Leu Glu Lys Asn Arg Asn Glu
70 75 80AGT TTG GCG CAA GAA AAA GTC CTA ACC AAC TAC CGC AAG TCT TTA GAT 344Ser Leu Ala Gln Glu Lys Val Leu Thr Asn Tyr Arg Lys Ser Leu Asp
85 90 95CAT TTG CAA AAA AAG CGA TCA TTT TTA CAA AAG AGG GTG TTT GAT ACG 392His Leu Gln Lys Lys Arg Ser Phe Leu Gln Lys Arg Val Phe Asp Thr
100 105 110CTT TTA CAG GAT TTC CTT TTT TCA CAA GCC CTA AAG GGG CAG AAT TTA 440Leu Leu Gln Asp Phe Leu Phe Ser Gln Ala Leu Lys Gly Gln Asn Leu115 120 125 130GCC TCT TCT AAT GAT GTT GTT TTG CAA GTG GCG TTT GAA AAC TTG CAC 488Ala Ser Ser Asn Asp Val Val Leu Gln Val Ala Phe Glu Asn Leu His
135 140 145CAA AGC ACT CTG TCT AAA ATG TCG CAA CTG AGC CAA GAA GAA AAG GAA 536Gln Ser Thr Leu Ser Lys Met Ser Gln Leu Ser Gln Glu Glu Lys Glu
150 155 160CTC AAT ACG CAA GCT TTA AAA GTC AAA AAC AGC ATT CAA AAA ATC TCA 584Leu Asn Thr Gln Ala Leu Lys Val Lys Asn Ser Ile Gln Lys Ile Ser
165 170 175TCC ATC ATA GAT GAG CAA AAA ACT CGT GAA GTA ACC TTA AAA TCC TTG 632Ser Ile Ile Asp Glu Gln Lys Thr Arg Glu Val Thr Leu Lys Ser Leu
180 185 190AAA ACC GAA CAA GAT AAG CTC ATT TTG AGC ATG CAA AAA GAT TAT GCG 680Lys Thr Glu Gln Asp Lys Leu Ile Leu Ser Met Gln Lys Asp Tyr Ala195 200 205 210ATC TAC AAC CAA CGC CTA ACC CTT TTA GAA AAA GAG CGC CAG AAT TTA 728Ile Tyr Asn Gln Arg Leu Thr Leu Leu Glu Lys Glu Arg Gln Asn Leu
215 220 225AAC GCT CTT TTA AAA CGC TTG AAT ATC ATC AAA CAA AAC AGA GAA AAT 776Asn Ala Leu Leu Lys Arg Leu Asn Ile Ile Lys Gln Asn Arg Glu Asn
230 235 240GAA GAA AAA GTC AGT TTGAAA AAA TCT TCT CAA GCC TTA GAA GTC AAA 824Glu Glu Lys Val Ser Leu Lys Lys Ser Ser Gln Ala Leu Glu Val Lys
245 250 255CAA GTG GCT AGC TCT TAT CAA AAT ATC AAC ACC ACG AGC TAT AAC GGA 872Gln Val Ala Ser Ser Tyr Gln Asn Ile Asn Thr Thr Ser Tyr Asn Gly
260 265 270CCA AAA ACG ATC GCT CCC TTG AAC GAT TAT GAA GTG GTG CAA AAA TTT 920Pro Lys Thr Ile Ala Pro Leu Asn Asp Tyr Glu Val Val Gln Lys Phe275 280 285 290GGC CCC TAT ATT GAC CCG GTT TAT AAT TTA AAA ATT TTT AGC GAG TCT 968Gly Pro Tyr Ile Asp Pro Val Tyr Asn Leu Lys Ile Phe Ser Glu Ser
295 300 305ATT ACG CTC GTG TCA AAA ACC CCA AAC GCT TTG GTG CGT AAT GTT TTA 1016Ile Thr Leu Val Ser Lys Thr Pro Asn Ala Leu Val Arg Asn Val Leu
310 315 320GAC GGG AAA ATC GTG TTC GCT AAA GAA ATC AAC ATG CTT AAA AAA GTC 1064Asp Gly Lys Ile Val Phe Ala Lys Glu Ile Asn Met Leu Lys Lys Val
325 330 335GTT ATC ATT GAG CAT AAA AAT GGG ATC CGC ACG ATT TAT TCT CAA TTG 1112Val Ile Ile Glu His Lys Asn Gly Ile Arg Thr Ile Tyr Ser Gln Leu
340 345 350GAT AAA ATC GCT CCC ACC ATT AAA AGC GGC ATG CGG ATC CAA AAA GGC 1160Asp Lys Ile Ala Pro Thr Ile Lys Ser Gly Met Arg Ile Gln Lys Gly355 360 365 370TAT GTT TTA GGG CGC ATT GAT CAA CGC TTG GGC TTT GAA GTT ACC ATG 1208Tyr Val Leu Gly Arg Ile Asp Gln Arg Leu Gly Phe Glu Val Thr Met
375 380 385AGA GAA AAA CAC ATC AAC CCC TTA GAA CTC ATC GCA CGC AAT TAAACAAAT 1259Arg Glu Lys His Ile Asn Pro Leu Glu Leu Ile Ala ArgAsn
390 395 400CGTTTTTATT GCCGATATTG GCTAAAGAAT TTATGCAAAC AAAT 1303
(2) Sequence 206 data:
(i) sequence characteristics:
(A) length: 400 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 206: met Tyr Lys Leu Gly Val Phe Leu Leu Ala Thr Leu Leu Ser Ala Asn 151015 Thr Gln Lys Val Ser Asp Ile Ala Lys Asp Ile Gln His Lys Glu Thr
20 25 30Leu Leu Lys Lys Thr His Glu Glu Lys Asn Gln Leu Asn Ser Arg Leu
35 40 45Ser Ser Leu Gly Glu Ala Ile Arg Ser Lys Glu Leu Gln Lys Ala Glu
50 55 60Met Glu Arg Gln Met Ile Ala Leu Lys Lys Ser Leu Glu Lys Asn Arg65 70 75 80Asn Glu Ser Leu Ala Gln Glu Lys Val Leu Thr Asn Tyr Arg Lys Ser
85 90 95Leu Asp His Leu Gln Lys Lys Arg Ser Phe Leu Gln Lys Arg Val Phe
100 105 110Asp Thr Leu Leu Gln Asp Phe Leu Phe Ser Gln Ala Leu Lys Gly Gln
115 120 125Asn Leu Ala Ser Ser Asn Asp Val Val Leu Gln Val Ala Phe Glu Asn
130 135 140Leu His Gln Ser Thr Leu Ser Lys Met Ser Gln Leu Ser Gln Glu Glu145150 155 160Lys Glu Leu Asn Thr Gln Ala Leu Lys Val Lys Asn Ser Ile Gln Lys
165 170 175Ile Ser Ser Ile Ile Asp Glu Gln Lys Thr Arg Glu Val Thr Leu Lys
180 185 190Ser Leu Lys Thr Glu Gln Asp Lys Leu Ile Leu Ser Met Gln Lys Asp
195 200 205Tyr Ala Ile Tyr Asn Gln Arg Leu Thr Leu Leu Glu Lys Glu Arg Gln
210 215 220Asn Leu Asn Ala Leu Leu Lys Arg Leu Asn Ile Ile Lys Gln Asn Arg225 230 235 240Glu Asn Glu Glu Lys Val Ser Leu Lys Lys Ser Ser Gln Ala Leu Glu
245 250 255Val Lys Gln Val Ala Ser Ser Tyr Gln Asn Ile Asn Thr Thr Ser Tyr
260 265 270Asn Gly Pro Lys Thr Ile Ala Pro Leu Asn Asp Tyr Glu Val Val Gln
275 280 285Lys Phe Gly Pro Tyr Ile Asp Pro Val Tyr Asn Leu Lys Ile Phe Ser
290 295 300Glu Ser Ile Thr Leu Val Ser Lys Thr Pro Asn Ala Leu Val Arg Asn305 310 315 320Val Leu Asp Gly Lys Ile Val Phe Ala Lys Glu Ile Asn Met Leu Lys
325 330 335Lys Val Val Ile Ile Glu His Lys Asn Gly Ile Arg Thr Ile Tyr Ser
340 345 350Gln Leu Asp Lys Ile Ala Pro Thr Ile Lys Ser Gly Met Arg Ile Gln
355 360 365Lys Gly Tyr Val Leu Gly Arg Ile Asp Gln Arg Leu Gly Phe Glu Val
370 375 380Thr Met Arg Glu Lys His Ile Asn Pro Leu Glu Leu Ile Ala Arg Asn385 390 395 400
(2) Sequence 207 data:
(i) sequence characteristics:
(A) length: 361bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...308
(D) Other information:
(xi) Description of the sequence: sequence 207: AGGATTTAAG ATTGCGTTTG AAGTTAGCTA GCGTATGCTT GGGCGTTTTG ATG AGT 56
Met Ser
1GGT TGT GCG TCT TCT TCG CCA ACT GGC ACT CTT ATC ACT ATG GTA ACG 104Gly Cys Ala Ser Ser Ser Pro Thr Gly Thr Leu Ile Thr Met Val Thr
5 10 15ATG CCA GTT TCT GGG AAT GAT GCA CAA TAC TCC AAA GAA GGG CGT GCG 152Met Pro Val Ser Gly Asn Asp Ala Gln Tyr Ser Lys Glu Gly Arg Ala
20 25 30AGT TGT TGG AGT GTT TTT AGT CTT GTG GCT GCC GGT AAT TGT TCG GTA 200Ser Cys Trp Ser Val Phe Ser Leu Val Ala Ala Gly Asn Cys Ser Val35 40 45 50GAA AAA GCG GCT AAA AGT GGC GGT GTT ACC AAG ATT AAA ATG GTG AGC 248Glu Lys Ala Ala Lys Ser Gly Gly Val Thr Lys Ile Lys Met Val Ser
5560 65CGT GAG ACA AAC AAC TTT TTA GGT ATT GTT GGC AAA TAC ACC ACG ATC 296Arg Glu Thr Asn Asn Phe Leu Gly Ile Val Gly Lys Tyr Thr Thr Ile
70 75 80GTT CAA GGC GAC TAGTTTTAAT ATTTAGAGAG CGTAGTTGAA TCGTCTTTCG TTCCA 353Val Gln Gly Asp
85CTCTAGGC 361
(2) Sequence 208 data:
(i) sequence characteristics:
(A) length: 86 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 208: met Ser Gly Cys Ala Ser Ser Ser Pro Thr Gly Thr Leu Ile Thr Met 151015 Val Thr Met Pro Val Ser Gly Asn Asp Ala Gln Tyr Ser Lys Glu Gly
20 25 30Arg Ala Ser Cys Trp Ser Val Phe Ser Leu Val Ala Ala Gly Asn Cys
35 40 45Ser Val Glu Lys Ala Ala Lys Ser Gly Gly Val Thr Lys Ile Lys Met
50 55 60Val Ser Arg Glu Thr Asn Asn Phe Leu Gly Ile Val Gly Lys Tyr Thr65 70 75 80Thr Ile Val Gln Gly Asp
85
(2) Sequence 209 data:
(i) sequence characteristics:
(A) length: 1564bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1511
(D) Other information:
(xi) Description of the sequence: sequence 209: TTTAAACCTG AATTTCATAT TTTTGATTTT TTAAAGGGAT TAGAGTTCTT ATG ATT 56
Met Ile
1GAA TGG ATG CAA AAT CAT AGA AAA TAT TTA GTG GTT ACA ATA TGG ATA 104Glu Trp Met Gln Asn His Arg Lys Tyr Leu Val Val Thr Ile Trp Ile
5 10 15AGC ACG ATC GCT TTT ATT GCC GCT GGG ATG ATA GGC TGG GGG CAA TAC 152Ser Thr Ile Ala Phe Ile Ala Ala Gly Met Ile Gly Trp Gly Gln Tyr
20 25 30AGC TTT TCT TTA GAT AGC GAT AGC GCT GCC AAA GTG GGA CAG ATT AAG 200Ser Phe Ser Leu Asp Ser Asp Ser Ala Ala Lys Val Gly Gln Ile Lys35 40 45 50ATT TCT CAA GAA GAA TTA GCC CAA GAA TAC CGC CGC CTT AAA GAC GCA 248Ile Ser Gln Glu Glu Leu Ala Gln Glu Tyr Arg Arg Leu Lys Asp Ala
55 60 65TAT GCT GAG TCT ATC CCT GAT TTT AAA GAA CTC ACC AAA GAT CAA ATC 296Tyr Ala Glu Ser Ile Pro Asp Phe Lys Glu Leu Thr Lys Asp Gln Ile
70 75 80AAA GCC ATG CAT TTA GAA AAA AGC GCT TTA GAT TCG CTC ATC AAT CAA 344Lys Ala Met His Leu Glu Lys Ser Ala Leu Asp Ser Leu Ile Asn Gln
85 90 95GCC TTA TTG AGA AAT CTC GCT TTA GAT TTA GGG CTT GGC GCT ACA AAG 392Ala Leu Leu Arg Asn Leu Ala Leu Asp Leu Gly Leu Gly Ala Thr Lys
100 105 110CAA GAA GTG GCG AAA GAG ATC AGA AAA ACG AGC GTT TTC CAA AAA GAT 440Gln Glu Val Ala Lys Glu Ile Arg Lys Thr Ser Val Phe Gln Lys Asp115 120 125 130GGC GTT TTT GAT GAA GAA TTG TAT AAA AAT ATC TTA AAG CAA AGC CAT 488Gly Val Phe Asp Glu Glu Leu Tyr Lys Asn Ile Leu Lys Gln Ser His
135 140 145TAC CGC CCC AAA CAT TTT GAA GAA AGC GTT GAA AGG CTT TTA ATC CTT 536Tyr Arg Pro Lys His Phe Glu Glu Ser Val Glu Arg Leu Leu Ile Leu
150 155 160CAA AAA ATC AGC ACT CTA TTC CCC AAA ACC ACT ACC CCT TTG GAG CAA 584Gln Lys Ile Ser Thr Leu Phe Pro Lys Thr Thr Thr Pro Leu Glu Gln
165 170 175TCC AGC CTA TCG CTT TGG GCA AAA TTG CAA GAC AAA TTA GAC ATT CTT 632Ser Ser Leu Ser Leu Trp Ala Lys Leu Gln Asp Lys Leu Asp Ile Leu
180 185 190ATC CTA AAC CCT AGT GAT GTT AAA ATC TCT CTT AAT GAA GAA GAG ATG 680Ile Leu Asn Pro Ser Asp Val Lys Ile Ser Leu Asn Glu Glu Glu Met195 200 205 210AAA AAA TAT TAC GAG TCC CAT AAA AAG GAT TTT AAA AAG CCC ACG AGC 728Lys Lys Tyr Tyr Glu Ser His Lys Lys Asp Phe Lys Lys Pro Thr Ser
215 220 225TTT AAA ACA CGC TCT TTA TAT TTT GAC GCT AGT TTG GAA AAA CCT GAT 776Phe Lys Thr Arg Ser Leu Tyr Phe Asp Ala Ser Leu Glu Lys Pro Asp
230 235 240TTG AAG GAG TTG GAG GAA TAC TAC CAT AAA AAC AAG GTG TCT TAT TTG 824Leu Lys Glu Leu Glu GluTyr Tyr His Lys Asn Lys Val Ser Tyr Leu
245 250 255GAC AAA GAG GGG AAA TTG CAG GAT TTT AAA AGC GTT CAA GAG CAA GTC 872Asp Lys Glu Gly Lys Leu Gln Asp Phe Lys Ser Val Gln Glu Gln Val
260 265 270AAG CAT GAT TTA AGC ATG CAA AAA GCG AAT GAA AAA GCC TTA AGG AGC 920Lys His Asp Leu Ser Met Gln Lys Ala Asn Glu Lys Ala Leu Arg Ser275 280 285 290TAT ATC GCT CTA AAA AAA GCG AAC GCG CAA AAC TAC ACC ACA CAA GAT 968Tyr Ile Ala Leu Lys Lys Ala Asn Ala Gln Asn Tyr Thr Thr Gln Asp
295 300 305TTT GAA GAG AAC AAC TCC CCC TAT ACT GCT GAA ATC ACG CAA AAA CTC 1016Phe Glu Glu Asn Asn Ser Pro Tyr Thr Ala Glu Ile Thr Gln Lys Leu
310 315 320ACC GCT CTC AAA CCC CTT GAA ATC CTA AAG CCA GAG CCT TTT AAA GAT 1064Thr Ala Leu Lys Pro Leu Glu Ile Leu Lys Pro Glu Pro Phe Lys Asp
325 330 335GGT TTT ATT GTG GTG CAA CTC ATC TCT CAA ATT AAA GAC GAA TTG CAA 1112Gly Phe Ile Val Val Gln Leu Ile Ser Gln Ile Lys Asp Glu Leu Gln
340 345 350AAT TTT AAT GAA GCT AAA AGC GCT CTT AAA ACC CGC CTA ACT CAA GAA 1160Asn Phe Asn Glu Ala Lys Ser Ala Leu Lys Thr Arg Leu Thr Gln Glu355 360 365 370AAA ACC CTT ATG GCG TTG CAA ACT TTA GCC AAA GAA AAG CTT AAG GAT 1208Lys Thr Leu Met Ala Leu Gln Thr Leu Ala Lys Glu Lys Leu Lys Asp
375 380 385TTT AAG GGC AAA AGC GTG GGC TAT GTA AGC CCT AAT TTT GGA GGC ACT 1256Phe Lys Gly Lys Ser Val Gly Tyr Val Ser Pro Asn Phe Gly Gly Thr
390395 400ATT AGT GAG CTT AAC CAA GAA GAA AGT GCT AAG TTT ATC AAC GCT CTT 1304Ile Ser Glu Leu Asn Gln Glu Glu Ser Ala Lys Phe Ile Asn Ala Leu
405 410 415TTT AAC CGC CAG GAA AAA AAG GGG TTT ATC GCT ATT AAT AAT AAA GTG 1352Phe Asn Arg Gln Glu Lys Lys Gly Phe Ile Ala Ile Asn Asn Lys Val
420 425 430GTG CTC TAT CAA ATC ACA GAA CAA AAT TTC AAC CAC TCA TTT AGT GCA 1400Val Leu Tyr Gln Ile Thr Glu Gln Asn Phe Asn His Ser Phe Ser Ala435 440 445 450GAA GAA AGC CAG TAT ATG CAG CGT TTA GTC AAT AAC ACT AAA ACG GAT 1448Glu Glu Ser Gln Tyr Met Gln Arg Leu Val Asn Asn Thr Lys Thr Asp
455 460 465TTT TTT GAT AAA GCG TTG ATA GAA GAA TTG AAA AAA CGC TAT AAG ATA 1496Phe Phe Asp Lys Ala Leu Ile Glu Glu Leu Lys Lys Arg Tyr Lys Ile
470 475 480GTC AAA TAC ATT CAA TAAATGCAAG GGGAAATCAT GGAACATAAA GAAATCGTTA T 1552Val Lys Tyr Ile Gln
485AGGGGTTGAT CT 1564
(2) Sequence 210 data:
(i) sequence characteristics:
(A) length: 487 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 2l 0: met Ile Glu Trp Met Gln Asn His Arg Lys Tyr Leu Val Val Thr Ile 151015 Trp Ile Ser Thr Ile Ala Phe Ile Ala Ala Gly Met Ile GlyTrp Gly
20 25 30Gln Tyr Ser Phe Ser Leu Asp Ser Asp Ser Ala Ala Lys Val Gly Gln
35 40 45Ile Lys Ile Ser Gln Glu Glu Leu Ala Gln Glu Tyr Arg Arg Leu Lys
50 55 60Asp Ala Tyr Ala Glu Ser Ile Pro Asp Phe Lys Glu Leu Thr Lys Asp65 70 75 80Gln Ile Lys Ala Met His Leu Glu Lys Ser Ala Leu Asp Ser Leu Ile
85 90 95Asn Gln Ala Leu Leu Arg Asn Leu Ala Leu Asp Leu Gly Leu Gly Ala
100 105 110Thr Lys Gln Glu Val Ala Lys Glu Ile Arg Lys Thr Ser Val Phe Gln
115 120 125Lys Asp Gly Val Phe Asp Glu Glu Leu Tyr Lys Asn Ile Leu Lys Gln
130 135 140Ser His Tyr Arg Pro Lys His Phe Glu Glu Ser Val Glu Arg Leu Leu145 150 155 160Ile Leu Gln Lys Ile Ser Thr Leu Phe Pro Lys Thr Thr Thr Pro Leu
165 170 175Glu Gln Ser Ser Leu Ser Leu Trp Ala Lys Leu Gln Asp Lys Leu Asp
180 185 190Ile Leu Ile Leu Asn Pro Ser Asp Val Lys Ile Ser Leu Asn Glu Glu
195 200 205Glu Met Lys Lys Tyr Tyr Glu Ser His Lys Lys Asp Phe Lys Lys Pro
210 215 220Thr Ser Phe Lys Thr Arg Ser Leu Tyr Phe Asp Ala Ser Leu Glu Lys225 230 235 240Pro Asp Leu Lys Glu Leu Glu Glu Tyr Tyr His Lys Asn Lys Val Ser
245 250 255Tyr Leu Asp Lys Glu Gly Lys Leu Gln Asp Phe Lys Ser Val Gln Glu
260 265 270Gln Val Lys His Asp Leu Ser Met Gln Lys Ala Asn Glu Lys Ala Leu
275 280 285Arg Ser Tyr Ile Ala Leu Lys Lys Ala Asn Ala Gln Asn Tyr Thr Thr
290 295 300Gln Asp Phe Glu Glu Asn Asn Ser Pro Tyr Thr Ala Glu Ile Thr Gln305 310 315 320Lys Leu Thr Ala Leu Lys Pro Leu Glu Ile Leu Lys Pro Glu Pro Phe
325 330 335Lys Asp Gly Phe Ile Val Val Gln Leu Ile Ser Gln Ile Lys Asp Glu
340 345 350Leu Gln Asn Phe Asn Glu Ala Lys Ser Ala Leu Lys Thr Arg Leu Thr
355 360 365Gln Glu Lys Thr Leu Met Ala Leu Gln Thr Leu Ala Lys Glu Lys Leu
370 375 380Lys Asp Phe Lys Gly Lys Ser Val Gly Tyr Val Ser Pro Asn Phe Gly385 390 395 400Gly Thr Ile Ser Glu Leu Asn Gln Glu Glu Ser Ala Lys Phe Ile Asn
405 410 415Ala Leu Phe Asn Arg Gln Glu Lys Lys Gly Phe Ile Ala Ile Asn Asn
420 425 430Lys Val Val Leu Tyr Gln Ile Thr Glu Gln Asn Phe Asn His Ser Phe
435 440 445Ser Ala Glu Glu Ser Gln Tyr Met Gln Arg Leu Val Asn Asn Thr Lys
450 455 460Thr Asp Phe Phe Asp Lys Ala Leu Ile Glu Glu Leu Lys Lys Arg Tyr465 470 475 480Lys Ile Val Lys Tyr Ile Gln
485
(2) Sequence 211 data:
(i) sequence characteristics:
(A) length: 1435bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1382
(D) Other information:
(xi) Description of the sequence: sequence 211: CAAAAAGATG GATTTTTGAG CGTCAAAGAG GCTATAGGAG CGGATTTAAG ATG AAA 56
Met Lys
1CAT TTT TCT GTT AAA AGA CTT TTA GGG CTT AGT TCT GTC TTG TTA GTC 104His Phe Ser Val Lys Arg Leu Leu Gly Leu Ser Ser Val Leu Leu Val
5 10 15ACT TTA GGA GCG AGC ATG CAC GCA CAA TCT TAC TTA CCC AAA CAT GAG 152Thr Leu Gly Ala Ser Met His Ala Gln Ser Tyr Leu Pro Lys His Glu
20 25 30AGC GTT ACC TTA AAA AAC GGG TTG CAA GTC GTG AGC GTC CCC CTA GAA 200Ser Val Thr Leu Lys Asn Gly Leu Gln Val Val Ser Val Pro Leu Glu35 40 45 50AAT AAA ACC GGG GTT ATA GAA GTG GAT GTG CTT TAT AAA GTC GGC TCT 248Asn Lys Thr Gly Val Ile Glu Val Asp Val Leu Tyr Lys Val Gly Ser
55 60 65AGA AAC GAA ACC ATG GGA AAG AGC GGG ATC GCT CAC ATG TTA GAG CAT 296Arg Asn Glu Thr Met Gly Lys Ser Gly Ile Ala His Met Leu Glu His
70 75 80TTG AAT TTT AAA AGC ACC AAA AAC CTT AAA GCC GGC GAA TTT GAT AAA 344Leu Asn Phe Lys Ser Thr Lys Asn Leu Lys Ala Gly Glu Phe Asp Lys
85 90 95ATC GTT AAG CGT TTT GGG GGC GTG AGT AAC GCT TCT ACG AGT TTT GAT 392Ile Val Lys Arg Phe Gly Gly Val Ser Asn Ala Ser Thr Ser Phe Asp
100 105 110ATT ACG CGC TAC TTC ATT AAA ACC AGT CAG GCT AAC TTG GAT AAG TCT 440Ile Thr Arg Tyr Phe Ile Lys Thr Ser Gln Ala Asn Leu Asp Lys Ser115 120 125 130TTA GAA TTG TTC GCT GAA ACC ATG GGT TCA TTG AAT TTA AAA GAA GAT 488Leu Glu Leu Phe Ala Glu Thr Met Gly Ser Leu Asn Leu Lys Glu Asp
135 140 145GAG ITT TTG CCT GAG CGT CAA GTG GTC GCT GAA GAA AGG CGA TGG CGC 536Glu Phe Leu Pro Glu Arg Gln Val Val Ala Glu Glu Arg Arg Trp Arg
150 155 160ACT GAT AAT TCC CCT ATC GGC ATG CTT TAT TTC CGC TTT TTT AAC ACC 584Thr Asp Asn Ser Pro Ile Gly Met Leu Tyr Phe Arg Phe Phe Asn Thr
165 170 175GCT TAT GTC TAT CAC CCC TAC CAT TGG ACG CCC ATT GGT TTT ATG GAT 632Ala Tyr Val Tyr His Pro Tyr His Trp Thr Pro Ile Gly Phe Met Asp
180 185 190GAT ATT CAA AAT TGG ACT TTA AAA GAC ATT AAA AAA TTC CAT TCG CTC 680Asp Ile Gln Asn Trp Thr Leu Lys Asp Ile Lys Lys Phe His Ser Leu195 200 205 210TAT TAT CAG CCT AAA AAC GCT ATC GTT TTG GTG GTA GGC GAT GTC AAT 728Tyr Tyr Gln Pro Lys Asn Ala Ile Val Leu Val Val Gly Asp Val Asn
215 220 225TCC CAA AAG GTT TTT GAA TTG AGT AAA AAG CAT TTT GAA TCC TTA AAA 776Ser Gln Lys Val Phe Glu Leu Ser Lys Lys His Phe Glu Ser Leu Lys
230 235 240AAC CTT GAT GAA AAA GCT ATC CCC ACC CCT TAC ATG AAA GAG CCT AAG 824Asn Leu Asp Glu Lys Ala Ile Pro Thr Pro Tyr Met Lys Glu Pro Lys
245 250 255CAA GAT GGA GCC AGA ACG GCA GTC GTG CAT AAA GAT GGG GTC CAT TTA 872Gln Asp Gly Ala Arg Thr Ala Val Val His Lys Asp Gly Val His Leu
260 265 270GAA TGG GTG GCC CTT GGG TAT AAA GTG CCT GCT TTC AAG CAT AAA GAT 920Glu Trp Val Ala Leu Gly Tyr Lys Val Pro Ala Phe Lys His Lys Asp275 280 285 290CAA GTC GCC TTA GAC GCA CTA AGT AGG CTT TTA GGC GAA GGC AAA AGC 968Gln Val Ala Leu Asp Ala Leu Ser Arg Leu Leu Gly Glu Gly Lys Ser
295 300 305TCG TGG TTG CAA AGC GAA TTA GTG GAT AAA AAA CGC TTG GCT TCT CAA 1016Ser Trp Leu Gln Ser Glu Leu Val Asp Lys Lys Arg Leu Ala Ser Gln
310 315 320GCT TTC TCG CAC AAC ATG CAA TTA CAA GAT GAA AGC GTG TTT TTA TTC 1064Ala Phe Ser His Asn Met Gln Leu Gln Asp Glu Ser Val Phe Leu Phe
325 330 335ATT GCG GGG GGT AAT CCT AAT GTC AAA GCC GAA GCC TTA CAA AAA GAA 1112Ile Ala Gly Gly Asn Pro Asn Val Lys Ala Glu Ala Leu Gln Lys Glu
340 345 350ATC GTA GCG CTT TTA GAA AAG CTG AAA AAA GGC GAA ATC ACT CAA GCG 1160Ile Val Ala Leu Leu Glu Lys Leu Lys Lys Gly Glu Ile Thr Gln Ala355 360 365 370GAA TTA GAC AAG CTC AAA ATC AAT CAA AAA GCT GAC TTT ATT TCT AAT 1208Glu Leu Asp Lys Leu Lys Ile Asn Gln Lys Ala Asp Phe Ile Ser Asn
375 380 385TTA GAA AGT TCT AGC GAT GTT GCG GGG CTT TTT GCG GAC TAT TTA GTG 1256Leu Glu Ser Ser Ser Asp Val Ala Gly Leu Phe Ala Asp Tyr Leu Val
390 395 400CAA AAC GAT ATT CAA GGC TTG ACG GAT TAC CAG CGA CAA TTT TTG GAT 1304Gln Asn Asp Ile Gln Gly Leu Thr Asp Tyr Gln Arg Gln Phe Leu Asp
405 410 415TTA AAA GTG AGC GAT TTG GTG CGT GTG GCC AAT GAA TAT TTT AAA GAC 1352Leu Lys Val Ser Asp Leu Val Arg Val Ala Asn Glu Tyr Phe Lys Asp
420 425 430ACC CAA TCA ACC ACC GTG TTT TTG AAA CCT TAAAAGAGCC TTATAACATG CAA 1405Thr Gln Ser Thr Thr Val Phe Leu Lys Pro435 440TTTCATTCAT CTAGCGCGTT GATTACGCCT 1435
(2) Sequence 212 data:
(i) sequence characteristics:
(A) length: 444 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 212: met Lys His Phe Ser Val Lys Arg Leu Leu Gly Leu Ser Ser Val Leu 151015 Leu Val Thr Leu Gly Ala Ser Met His Ala Gln Ser Tyr Leu Pro Lys
20 25 30His Glu Ser Val Thr Leu Lys Asn Gly Leu Gln Val Val Ser Val Pro
35 40 45Leu Glu Asn Lys Thr Gly Val Ile Glu Val Asp Val Leu Tyr Lys Val
50 55 60Gly Ser Arg Asn Glu Thr Met Gly Lys Ser Gly Ile Ala His Met Leu65 70 75 80Glu His Leu Asn Phe Lys Ser Thr Lys Asn Leu Lys Ala Gly Glu Phe
85 90 95Asp Lys Ile Val Lys Arg Phe Gly Gly Val Ser Asn Ala Ser Thr Ser
100 105 110Phe Asp Ile Thr Arg Tyr Phe Ile Lys Thr Ser Gln Ala Asn Leu Asp
115 120 125Lys Ser Leu Glu Leu Phe Ala Glu Thr Met Gly Ser Leu Asn Leu Lys
130 135 140Glu Asp Glu Phe Leu Pro Glu Arg Gln Val Val Ala Glu Glu Arg Arg145 150 155 160Trp Arg Thr Asp Asn Ser Pro Ile Gly Met Leu Tyr Phe Arg Phe Phe
165 170 175Asn Thr Ala Tyr Val Tyr His Pro Tyr His Trp Thr Pro Ile Gly Phe
180 185 190Met Asp Asp Ile Gln Asn Trp Thr Leu Lys Asp Ile Lys Lys Phe His
195 200 205Ser Leu Tyr Tyr Gln Pro Lys Asn Ala Ile Val Leu Val Val Gly Asp
210 215 220Val Asn Ser Gln Lys Val Phe Glu Leu Ser Lys Lys His Phe Glu Ser225 230 235 240Leu Lys Asn Leu Asp Glu Lys Ala Ile Pro Thr Pro Tyr Met Lys Glu
245 250 255Pro Lys Gln Asp Gly Ala Arg Thr Ala Val Val His Lys Asp Gly Val
260 265 270His Leu Glu Trp Val Ala Leu Gly Tyr Lys Val Pro Ala Phe Lys His
275 280 285Lys Asp Gln Val Ala Leu Asp Ala Leu Ser Arg Leu Leu Gly Glu Gly
290 295 300Lys Ser Ser Trp Leu Gln Ser Glu Leu Val Asp Lys Lys Arg Leu Ala305 310 315 320Ser Gln Ala Phe Ser His Asn Met Gln Leu Gln Asp Glu Ser Val Phe
325 330 335Leu Phe Ile Ala Gly Gly Asn Pro Asn Val Lys Ala Glu Ala Leu Gln
340 345 350Lys Glu Ile Val Ala Leu Leu Glu Lys Leu Lys Lys Gly Glu Ile Thr
355 360 365Gln Ala Glu Leu Asp Lys Leu Lys Ile Asn Gln Lys Ala Asp Phe Ile
370 375 380Ser Asn Leu Glu Ser Ser Ser Asp Val Ala Gly Leu Phe Ala Asp Tyr385 390 395 400Leu Val Gln Asn Asp Ile Gln Gly Leu Thr Asp Tyr Gln Arg Gln Phe
405 410 415Leu Asp Leu Lys Val Ser Asp Leu Val Arg Val Ala Asn Glu Tyr Phe
420 425 430Lys Asp Thr Gln Ser Thr Thr Val Phe Leu Lys Pro
435 440
(2) Sequence 213 data:
(i) sequence characteristics:
(A) length: 250bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...197
(D) Other information:
(xi) Description of the sequence: sequence 213: ATATAATCTT TTCTTAATTT TGAAGTTTAG CAAATTTTAA GGAAGTAACC ATG ATG 56
Met Met
1AAA AAA ACC CTT TTT ATC TCT TTG GCT TTA GCG TTA AGC TTG AAT GCG 104Lys Lys Thr Leu Phe Ile Ser Leu Ala Leu Ala Leu Ser Leu Asn Ala
5 10 15GGC AAT ATC CAA ATC CAG AGC ATG CCC AAA GTT AAA GAG CGA GTG AGT 152Gly Asn Ile Gln Ile Gln Ser Met Pro Lys Val Lys Glu Arg Val Ser
20 25 30GTC CCC TCT AAA GAC GAT ACG GAT CTA TTC TTA CCA CGA TTC TAT TAAGG 202Val Pro Ser Lys Asp Asp Thr Asp Leu Phe Leu Pro Arg Phe Tyr35 40 45ACTCTATTAA GGCGGTGGTG AATATCTCCA CTGAAAAGAA GATTAAAA 250
(2) Sequence 214 data:
(i) sequence characteristics:
(A) length: 49 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 214: met Met Lys Lys Thr Leu Phe Ile Ser Leu Ala Leu Ala Leu Ser Leu 151015 Asn Ala Gly Asn Ile Gln lle Gln Ser Met Pro Lys Val Lys Glu Arg
20 25 30Val Ser Val Pro Ser Lys Asp Asp Thr Asp Leu Phe Leu Pro Arg Phe
35 40 45Tyr
(2) Sequence 215 data:
(i) sequence characteristics:
(A) length: 328bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...275
(D) Other information:
(xi) Description of the sequence: sequence 215: TTAAGATTGC GGTTATACTG AAAAAAACAA TATGAAATCA AGGAGCTTGT ATG CAA 56
Met Gln
1CAG CGT CAT TTA GGC CCT TTA AAA GTG GGT GCA TTA GCT CTA GGG TGC 104Gln Arg His Leu Gly Pro Leu Lys Val Gly Ala Leu Ala Leu Gly Cys
5 10 15ATG GGC ATG ACT TAT GGG TAT GGG GAA GTC CAT GAT AAA AAG CAG ATG 152Met Gly Met Thr Tyr Gly Tyr Gly Glu Val His Asp Lys Lys Gln Met
20 25 30GTT AAA CTT ATC CAT AAG GCT TTG GAA TTG GGT ATT AAC TTT TTT GAC 200Val Lys Leu Ile His Lys Ala Leu Glu Leu Gly Ile Asn Phe Phe Asp35 40 45 50ACT GCA GAG GCT TAT GGG GAA GAT AAT GAA AAG CTT TTA GGC GAA CGA 248Thr Ala Glu Ala Tyr Gly Glu Asp Asn Glu Lys Leu Leu Gly Glu Arg
55 60 65TCA AGC CTT TTA AAG ACA AGG TTG TGG TAGCGAGCAA GTTTGGGATT TACTACG 302Ser Ser Leu Leu Lys Thr Arg Leu Trp
70 75CAGATCCTAA TGACAAATAC GCAACC 328
(2) Sequence 216 data:
(i) sequence characteristics:
(A) length: 75 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 216: met Gln Gln Arg His Leu Gly Pro Leu Lys Val Gly Ala Leu Ala Leu 151015 Gly Cys Met Gly Met Thr Tyr Gly Tyr Gly Glu Val His Asp Lys Lys
20 25 30Gln Met Val Lys Leu Ile His Lys Ala Leu Glu Leu Gly Ile Asn Phe
35 40 45Phe Asp Thr Ala Glu Ala Tyr Gly Glu Asp Asn Glu Lys Leu Leu Gly
50 55 60Glu Arg Ser Ser Leu Leu Lys Thr Arg Leu Trp65 70 75
(2) Sequence 217 data:
(i) sequence characteristics:
(A) length: 649bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...596
(D) Other information:
(xi) Description of the sequence: sequence 217: CGAATTGCTG TATAGTTAGC GTTTTTAATT CAAAATGAAG TGAGGAAACA ATG AAA 56
Met Lys
1AAA GCG TTA ATA TCC ACC CTT TTT GGT GTT AGT TTG GCG TTT GCA AAA 104Lys Ala Leu Ile Ser Thr Leu Phe Gly Val Ser Leu Ala Phe Ala Lys
5 10 15CCT TAT ACG ATT GAT AAG GCA AAC TCT AGC GTG TGG TTT GAG GTC AAA 152Pro Tyr Thr Ile Asp Lys Ala Asn Ser Ser Val Trp Phe Glu Val Lys
20 25 30CAC TTC ACG TTC AAT GAA ACA AGA GGC GCG TTT GAT AAT TTT GAT GGC 200His Phe Thr Phe Asn Glu Thr Arg Gly Ala Phe Asp Asn Phe Asp Gly35 40 45 50AAA ATT GAT CTA GAG CCC AAC ACT AAA ATG CTC AGC GTT TTT GAA GGC 248Lys Ile Asp Leu Glu Pro Asn Thr Lys Met Leu Ser Val Phe Glu Gly
55 60 65AAT ATT GAT GTG AAA AGC GTC AAT ACT AGG GAT AGA AAA AGA GAT AAC 296Asn Ile Asp Val Lys Ser Val Asn Thr Arg Asp Arg Lys Arg Asp Asn
70 75 80CAC TTG AAA ACA GCG GAC TTT TTT GAT GTG GTA AAA TAC CCC AAA GGG 344His Leu Lys Thr Ala Asp Phe Phe Asp Val Val Lys Tyr Pro Lys Gly
85 90 95AGC TTT AAA ATG ACC AAA TAC GAA GAT GGT AAA ATC TAT GGG GAT TTG 392Ser Phe Lys Met Thr Lys Tyr Glu Asp Gly Lys Ile Tyr Gly Asp Leu
100 105 110ACT CTT CGT GGC GTA ACC AAG CCT GTC GTA TTG GAA GCC AAA ATC CAA 440Thr Leu Arg Gly Val Thr Lys Pro Val Val Leu Glu Ala Lys Ile Gln115 120125 130GCC CCC TTA CAA AAC CCC ATG AAT AAA AAA GAA TTC ATG GTG TTA CAA 488Ala Pro Leu Gln Asn Pro Met Asn Lys Lys Glu Phe Met Val Leu Gln
135 140 145GCT GAA GGC AAA ATC AAC CGC AAG GAT TTT GGT ATC GGT AAA ACC TTT 536Ala Glu Gly Lys Ile Asn Arg Lys Asp Phe Gly Ile Gly Lys Thr Phe
150 155 160AGC GAT GCT GTC GTT GGA GAT GAG GTA AAG ATT GAG CTC AAA CTA GAA 584Ser Asp Ala Val Val Gly Asp Glu Val Lys Ile Glu Leu Lys Leu Glu
165 170 175GCT TAC GCC CAA TAATCGTTTT GCAAGAGATA GATATCTTCT TCTCTTGCGT TTTTC 641Ala Tyr Ala Gln
180TAACAGCA 649
(2) Sequence 218 data:
(i) sequence characteristics:
(A) length: 182 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 218: met Lys Lys Ala Leu Ile Ser Thr Leu Phe Gly Val Ser Leu Ala Phe 151015 Ala Lys Pro Tyr Thr Ile Asp Lys Ala Asn Ser Ser Val Trp Phe Glu
20 25 30Val Lys His Phe Thr Phe Asn Glu Thr Arg Gly Ala Phe Asp Asn Phe
35 40 45Asp Gly Lys Ile Asp Leu Glu Pro Asn Thr Lys Met Leu Ser Val Phe
50 55 60Glu Gly Asn Ile Asp Val Lys Ser Val Asn Thr Arg Asp Arg Lys Arg65 70 75 80Asp Asn His Leu Lys Thr Ala Asp Phe Phe Asp Val Val Lys Tyr Pro
85 90 95Lys Gly Ser Phe Lys Met Thr Lys Tyr Glu Asp Gly Lys Ile Tyr Gly
100 105 110Asp Leu Thr Leu Arg Gly Val Thr Lys Pro Val Val Leu Glu Ala Lys
115 120 125Ile Gln Ala Pro Leu Gln Asn Pro Met Asn Lys Lys Glu Phe Met Val
130 135 140Leu Gln Ala Glu Gly Lys Ile Asn Arg Lys Asp Phe Gly Ile Gly Lys145 150 155 160Thr Phe Ser Asp Ala ValVal Gly Asp Glu Val Lys Ile Glu Leu Lys
165 170 175Leu Glu Ala Tyr Ala Gln
180
(2) Sequence 219 data:
(i) sequence characteristics:
(A) length: 478bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...425
(D) Other information:
(xi) Description of the sequence: sequence 219: TCCGTTCGCA ACAAGAATTT TCTTGTTATC TTAATGTAAA GGTCAAAACG ATG AAA 56
Met LysAAG TTA GCC GCT TTA TTT TTA GTA AGC GTG TTG GGG GTT ATG GGT TTA104Lys Leu Ala Ala Leu Phe Leu Val Ser Val Leu Gly Val Met Gly Leu
5 10 15AAC GCA TGG GAG CAA ACC CTA AAA GCT AAT GAC TTG GAA GTG AAA ATC 152Asn Ala Trp Glu Gln Thr Leu Lys Ala Asn Asp Leu Glu Val Lys Ile
20 25 30AAA TCC GTG GGT AAC CCC ATT AAA GGC GAT AAC ACT TTC ATT CTC AGC 200Lys Ser Val Gly Asn Pro Ile Lys Gly Asp Asn Thr Phe Ile Leu Ser35 40 45 50CCC ACT TTA AAA GGT AAG GCT TTA GAA AAA GCT ATC GTT AGG GTG CAG 248Pro Thr Leu Lys Gly Lys Ala Leu Glu Lys Ala Ile Val Arg Val Gln
55 60 65TTT ATG ATG CCT GAA ATG CCC GGC ATG CCA GCG ATG AAA GAA ATG GCG 296Phe Met Met Pro Glu Met Pro Gly Met Pro Ala Met Lys Glu Met Ala
70 75 80CAA GTG AGT GAA AAA AAC GGC CTT TAT GAA GCT AAA ACC AAT CTT TCT 344Gln Val Ser Glu Lys Asn Gly Leu Tyr Glu Ala Lys Thr Asn Leu Ser
85 90 95ATG AAC GGG ACA TGG CAG GTT AGG GTG GAT ATT AAA TCT AAA GAG GGT 392Met Asn Gly Thr Trp Gln Val Arg Val Asp Ile Lys Ser Lys Glu Gly
100 105 110CAG GTT TAT CGC GCT AAA ACA AGC CTG GAT TTA TAAGAGCATG CTATCTTTTA 445Gln Val Tyr Arg Ala Lys Thr Ser Leu Asp Leu115 120 125TAAGCGCGTT TGATAAAAGG GGCGTTTCAA TAC 478
(2) Sequence 220 data:
(i) sequence characteristics:
(A) length: 125 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 220: met Lys Lys Leu Ala Ala Leu Phe Leu Val Ser Val Leu Gly Val Met 151015 Gly Leu Asn Ala Trp Glu Gln Thr Leu Lys Ala Asn Asp Leu Glu Val
20 25 30Lys Ile Lys Ser Val Gly Asn Pro Ile Lys Gly Asp Asn Thr Phe Ile
35 40 45Leu Ser Pro Thr Leu Lys Gly Lys Ala Leu Glu Lys Ala Ile Val Arg
50 55 60Val Gln Phe Met Met Pro Glu Met Pro Gly Met Pro Ala Met Lys Glu65 70 75 80Met Ala Gln Val Ser Glu Lys Asn Gly Leu Tyr Glu Ala Lys Thr Asn
85 90 95Leu Ser Met Asn Gly Thr Trp Gln Val Arg Val Asp Ile Lys Ser Lys
100 105 110Glu Gly Gln Val Tyr Arg Ala Lys Thr Ser Leu Asp Leu
115 120 125
(2) Sequence 221 data:
(i) sequence characteristics:
(A) length: 1117bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1064
(D) Other information:
(xi) Description ofthe sequence: sequence 221: AGCGCTTTAA ATAGCACTTA TTTGTCTTTA CAAAACCTTA AAGGATTAGA ATG AAA 56
Met Lys
1CGG ATT TTA TGG TTA GCC TTG ATT TTA TTT TTT AGC CCC TTA TTC GCT 104Arg Ile Leu Trp Leu Ala Leu Ile Leu Phe Phe Ser Pro Leu Phe Ala
5 10 15AAC GCT CAA AAA ACT CAA GAA ATT AAA AAA ACT AAA GAA GCT AAA AGC 152Asn Ala Gln Lys Thr Gln Glu Ile Lys Lys Thr Lys Glu Ala Lys Ser
20 25 30CAA ACC CGT TTT AAT ATT TCC ACC ACT AAG GTC ATA GAA AAA GAA TTT 200Gln Thr Arg Phe Asn Ile Ser Thr Thr Lys Val Ile Glu Lys Glu Phe35 40 45 50TCT CAA AGC CGG CGC TAT TAC GCG CTT TTA GAG CCC AAT GAA GCG CTG 248Ser Gln Ser Arg Arg Tyr Tyr Ala Leu Leu Glu Pro Asn Glu Ala Leu
55 60 65ATT TTT TCT CAA ACC CTG CGT TTT GAT GGC TAT GTG GAA AAG CTT TAT 296Ile Phe Ser Gln Thr Leu Arg Phe Asp Gly Tyr Val Glu Lys Leu Tyr
70 75 80GCG AAT AAA ACC TAT ACC CCC ATT AAA AAG GGC GAC AGG TTA TTG AGC 344Ala Asn Lys Thr Tyr Thr Pro Ile Lys Lys Gly Asp Arg Leu Leu Ser
85 90 95GTG TAT TCC CCT GAA TTA GTG AGC GCT CAA AGC GAA TTG CTA TCA TCA 392Val Tyr Ser Pro Glu Leu Val Ser Ala Gln Ser Glu Leu Leu Ser Ser
100 105 110TTG AAA TTC AAC CAA CAA GTG GGA GCG ATT AAA GAA AAA TTA AAA CTA 440Leu Lys Phe Asn Gln Gln Val Gly Ala Ile Lys Glu Lys Leu Lys Leu115 120 125 130TTA GGG TTA GAA AAC TCT AGC ATT GAA AAA ATC ATT AGCAGC CAT AAA 488Leu Gly Leu Glu Asn Ser Ser Ile Glu Lys Ile Ile Ser Ser His Lys
135 140 145GTC CAA AAT GAA ATG ACT ATT TAC TCT CAC TTC AAC GGC ATT ATT TTT 536Val Gln Asn Glu Met Thr Ile Tyr Ser His Phe Asn Gly Ile Ile Phe
150 155 160AAA AAA AGC CCG GAT CTC AAT GAG GGG AGC TTC ATT AAA AAA GGG CAA 584Lys Lys Ser Pro Asp Leu Asn Glu Gly Ser Phe Ile Lys Lys Gly Gln
165 170 175GAG TTG TTT CAA ATC ATA GAT TTA AGC CAA TTG TGG GCG CTG GTT AAA 632Glu Leu Phe Gln Ile Ile Asp Leu Ser Gln Leu Trp Ala Leu Val Lys
180 185 190GTC AAT CAA GAG GAT TTA GAA TTT TTA AAA AAC ACG CAT AAA GCG ATC 680Val Asn Gln Glu Asp Leu Glu Phe Leu Lys Asn Thr His Lys Ala Ile195 200 205 210TTG TTT GTA GAA GGG ATT AAA GGC GAG CAA GAA ATC ACG CTT GAA AAT 728Leu Phe Val Glu Gly Ile Lys Gly Glu Gln Glu Ile Thr Leu Glu Asn
215 220 225ATC AAC CCC ATC ATC AAC AAA GAA GAT AAA ATG CTA GAA GCG CGC TTC 776Ile Asn Pro Ile Ile Asn Lys Glu Asp Lys Met Leu Glu Ala Arg Phe
230 235 240AAT GTG CCT AAT GTT AAA CAG ATT TAT TAC CCT AAC ATG TTC GCT CAA 824Asn Val Pro Asn Val Lys Gln Ile Tyr Tyr Pro Asn Met Phe Ala Gln
245 250 255GTA GAA ATC TTT CAA AAA CCA CAA AAA ATG AAG ATT TTG CCT AAA GAA 872Val Glu Ile Phe Gln Lys Pro Gln Lys Met Lys Ile Leu Pro Lys Glu
260 265 270GCG GTT TTG ATT AAA GGG GGG AAA GCT ATC GTG TTT AAA AAA GAC GAT 920Ala Val Leu Ile Lys Gly Gly Lys Ala Ile Val Phe Lys LysAsp Asp275 280 285 290TTT GGC TTA AGC CCG TTA GAA ATT AAA GCC GTC CGC TTG AGC GAT GGG 968Phe Gly Leu Ser Pro Leu Glu Ile Lys Ala Val Arg Leu Ser Asp Gly
295 300 305AGT TAT GAG ATT TTA GAG GGT TTA AAG GCG GGC GAA GAA GTC GCT AAT 1016Ser Tyr Glu Ile Leu Glu Gly Leu Lys Ala Gly Glu Glu Val Ala Asn
310 315 320AAC GCT TTA TTC GTG CTA GAC GCT GAC GCT CAA AAC AAT GGG GAT TAT T 1065Asn Ala Leu Phe Val Leu Asp Ala Asp Ala Gln Asn Asn Gly Asp Tyr
325 330 335GAATGATAGA AAAGATCATT GATTTAAGCG TTAAAAACAA ACTCCTTACC AC 1117
(2) Sequence 222 data:
(i) sequence characteristics:
(A) length: 338 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 222: met Lys Arg Ile Leu Trp Leu Ala Leu Ile Leu Phe Phe Ser Pro Leu 151015 Phe Ala Asn Ala Gln Lys Thr Gln Glu Ile Lys Lys Thr Lys Glu Ala
20 25 30Lys Ser Gln Thr Arg Phe Asn Ile Ser Thr Thr Lys Val Ile Glu Lys
35 40 45Glu Phe Ser Gln Ser Arg Arg Tyr Tyr Ala Leu Leu Glu Pro Asn Glu
50 55 60Ala Leu Ile Phe Ser Gln Thr Leu Arg Phe Asp Gly Tyr Val Glu Lys65 70 7580Leu Tyr Ala Asn Lys Thr Tyr Thr Pro Ile Lys Lys Gly Asp Arg Leu
85 90 95Leu Ser Val Tyr Ser Pro Glu Leu Val Ser Ala Gln Ser Glu Leu Leu
100 105 110Ser Ser Leu Lys Phe Asn Gln Gln Val Gly Ala Ile Lys Glu Lys Leu
115 120 125Lys Leu Leu Gly Leu Glu Asn Ser Ser Ile Glu Lys Ile Ile Ser Ser
130 135 140His Lys Val Gln Asn Glu Met Thr Ile Tyr Sar His Phe Asn Gly Ile145 150 155 160Ile Phe Lys Lys Ser Pro Asp Leu Asn Glu Gly Ser Phe Ile Lys Lys
165 170 175Gly Gln Glu Leu Phe Gln Ile Ile Asp Leu Ser Gln Leu Trp Ala Leu
180 185 190Val Lys Val Asn Gln Glu Asp Leu Glu Phe Leu Lys Asn Thr His Lys
195 200 205Ala Ile Leu Phe Val Glu Gly Ile Lys Gly Glu Gln Glu Ile Thr Leu
210 215 220Glu Asn Ile Asn Pro Ile Ile Asn Lys Glu Asp Lys Met Leu Glu Ala225 230 235 240Arg Phe Asn Val Pro Asn Val Lys Gln Ile Tyr Tyr Pro Asn Met Phe
245 250 255Ala Gln Val Glu Ile Phe Gln Lys Pro Gln Lys Met Lys Ile Leu Pro
260 265 270Lys Glu Ala Val Leu Ile Lys Gly Gly Lys Ala Ile Val Phe Lys Lys
275 280 285Asp Asp Phe Gly Leu Ser Pro Leu Glu Ile Lys Ala Val Arg Leu Ser
290 295300Asp Gly Ser Tyr Glu Ile Leu Glu Gly Leu Lys Ala Gly Glu Glu Val305 310 315 320Ala Asn Asn Ala Leu Phe Val Leu Asp Ala Asp Ala Gln Asn Asn Gly
325 330 335Asp Tyr
(2) Sequence 223 data:
(i) sequence characteristics:
(A) length: 1249bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1196
(D) Other information:
(xi) Description of the sequence: sequence 223: AAAACTTAGA TAAAATAACA CGATAAAACC ATAGTAATAA AGATAACCCC ATG AGA 56
Met Arg
1TTT TTT TGC TTT TTC TTA TTT TTT CTA ACC TTT TCA AAC GCA CAG ATA 104Phe Phe Cys Phe Phe Leu Phe Phe Leu Thr Phe Ser Asn Ala Gln Ile
5 10 15ATG ATG ACT TTT GAT TCT CAA ACT AAC GCC AAA CTC TCG CGC TCT AAC 152Met Met Thr Phe Asp Ser Gln Thr Asn Ala Lys Leu Ser Arg Ser Asn
20 25 30GAA CAG CTT TCA GAC ATG CTC TAT AAA CTC AAT GAA AGT TTA AGA ATC 200Glu Gln Leu Ser Asp Met Leu Tyr Lys Leu Asn Glu Ser Leu Arg Ile35 40 45 50TAT CAA AGC GTG CTT TCC AAT AAC CAA GAT CAA CTC AAA GAA ATC AAA 248Tyr Gln Ser Val Leu Ser Asn Asn Gln Asp Gln Leu Lys Glu Ile Lys
55 60 65AAA GCT AAC AGC ACC CTA AAT AGC CAA AGG CGT TTT TTT AAC GCC AGC 296Lys Ala Asn Ser Thr Leu Asn Ser Gln Arg Arg Phe Phe Asn Ala Ser
70 75 80CAG ATC CGC CTT ATG GAC ACT GAT GCA CTA TTG AAA CAA AGC GCT TTG 344Gln Ile Arg Leu Met Asp Thr Asp Ala Leu Leu Lys Gln Ser Ala Leu
85 90 95GAA TTA GAA AAA TTA CAA GCT TTA GAA AAA CAC ATA AAA AAG GGC ATG 392Glu Leu Glu Lys Leu Gln Ala Leu Glu Lys His Ile Lys Lys Gly Met
100 105 110GAA CAA GAA CGC TTA ATA GAA GAA TCC CAA ACG CTT TTT TTA CAA GAG 440Glu Gln Glu Arg Leu Ile Glu Glu Ser Gln Thr Leu Phe Leu Gln Glu115 120 125 130CAT TGC CCT TAT TTG AGC GGC GTT AAG AAT TTA GAA GAG GCT TCA AAC 488His Cys Pro Tyr Leu Ser Gly Val Lys Asn Leu Glu Glu Ala Ser Asn
135 140 145GCT TTA GAA GTC CAA GAG CAA AAC AAC GCC CTT TTC TTA CTC AAA GAG 536Ala Leu Glu Val Gln Glu Gln Asn Asn Ala Leu Phe Leu Leu Lys Glu
150 155 160CCT AAA CTC GCC CGT TTG CTC TCA CGA TTG GAT TTG ATG AGC GCT TTA 584Pro Lys Leu Ala Arg Leu Leu Ser Arg Leu Asp Leu Met Ser Ala Leu
165 170 175AAC GCC TTG TGC GAT CAG GTT TTA GAA AAC CAA GCC CAT AAC CAA CAA 632Asn Ala Leu Cys Asp Gln Val Leu Glu Asn Gln Ala His Asn Gln Gln
180 185 190TCC CAT AAC AAA ATT TTA GAA TAC AAC GCT CTT AAA AAC CAT GAT TTT 680Ser His Asn Lys Ile Leu Glu Tyr Asn Ala Leu Lys Asn His Asp Phe195 200 205210CAA GCC TAT AAA GCC ATG CGT TTG AAA AAA TTT AAA AAC AAG CTT CAA 728Gln Ala Tyr Lys Ala Met Arg Leu Lys Lys Phe Lys Asn Lys Leu Gln
215 220 225AGT CAA ATC CAA GCC CAA GAA GAC GCT CTA AAA ACC TTT TTA CCC TTA 776Ser Gln Ile Gln Ala Gln Glu Asp Ala Leu Lys Thr Phe Leu Pro Leu
230 235 240GAA AAA CGC TTG GAA ACT TTA AAA ACG CAT TTT TTA TGC GAT AAA GAA 824Glu Lys Arg Leu Glu Thr Leu Lys Thr His Phe Leu Cys Asp Lys Glu
245 250 255AAC CTA AAA TCA TGC GCT AAA GAA TTG CAC CAA CGC TAC CAA AAC GCC 872Asn Leu Lys Ser Cys Ala Lys Glu Leu His Gln Arg Tyr Gln Asn Ala
260 265 270CTT ATA GAG CGA GAT AAA GAA TTA AAA AAC GCT AAA AAT AAT AAA GAA 920Leu Ile Glu Arg Asp Lys Glu Leu Lys Asn Ala Lys Asn Asn Lys Glu275 280 285 290AAG CAT GCT CTA ATC TTA GCC AAT TAC GAG CAT ACT TTA AAA ACC TTG 968Lys His Ala Leu Ile Leu Ala Asn Tyr Glu His Thr Leu Lys Thr Leu
295 300 305AAT ATA GAA TTT TTA AGC GAA TTA AAT AAG CAA ATG GCG TTT TTG AAT 1016Asn Ile Glu Phe Leu Ser Glu Leu Asn Lys Gln Met Ala Phe Leu Asn
310 315 320GAA ACC ATG GCG TTA AAC GCC CGA GTT TTA GCC CTT TTA GCC AAA CAG 1064Glu Thr Met Ala Leu Asn Ala Arg Val Leu Ala Leu Leu Ala Lys Gln
325 330 335CAT GCC AAA ACG CCA AAG CCT TTC AAT TTG AGC GGT GGT TTA AGC GGT 1112His Ala Lys Thr Pro Lys Pro Phe Asn Leu Ser Gly Gly Leu Ser Gly
340 345 350GAT TTG AGC GGT GGG AAA GCT CTT ATT AAA AAT ATC CGC TTAGAT CCG 1160Asp Leu Ser Gly Gly Lys Ala Leu Ile Lys Asn Ile Arg Leu Asp Pro355 360 365 370CAT GGA TTC CCT AGC TTT AAA AAT TTT AAG CAA GAG TAGGACAATA TTTGAC 1212His Gly Phe Pro Ser Phe Lys Asn Phe Lys Gln Glu
375 380AAGCAAAAAC AATTATAGTA AAATAAGAGC ATAACTT 1249
(2) Data of sequence 224:
(i) sequence characteristics:
(A) length: 382 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 224: met Arg Phe Phe Cys Phe Phe Leu Phe Phe Leu Thr Phe Ser Asn Ala 151015 Gln Ile Met Met Thr Phe Asp Ser Gln Thr Asn Ala Lys Leu Ser Arg
20 25 30Ser Asn Glu Gln Leu Ser Asp Met Leu Tyr Lys Leu Asn Glu Ser Leu
35 40 45Arg Ile Tyr Gln Ser Val Leu Ser Asn Asn Gln Asp Gln Leu Lys Glu
50 55 60Ile Lys Lys Ala Asn Ser Thr Leu Asn Ser Gln Arg Arg Phe Phe Asn65 70 75 80Ala Ser Gln Ile Arg Leu Met Asp Thr Asp Ala Leu Leu Lys Gln Ser
85 90 95Ala Leu Glu Leu Glu Lys Leu Gln Ala Leu Glu Lys His Ile Lys Lys
100 105 110Gly Met Glu Gln Glu Arg Leu Ile Glu Glu Ser Gln Thr Leu Phe Leu
115 120 125Gln Glu His Cys Pro Tyr Leu Ser Gly Val Lys Asn Leu Glu Glu Ala
130 135 140Ser Asn Ala Leu Glu Val Gln Glu Gln Asn Asn Ala Leu Phe Leu Leu145 150 155 160Lys Glu Pro Lys Leu Ala Arg Leu Leu Ser Arg Leu Asp Leu Met Ser
165 170 175Ala Leu Asn Ala Leu Cys Asp Gln Val Leu Glu Asn Gln Ala His Asn
180 185 190Gln Gln Ser His Asn Lys Ile Leu Glu Tyr Asn Ala Leu Lys Asn His
195 200 205Asp Phe Gln Ala Tyr Lys Ala Met Arg Leu Lys Lys Phe Lys Asn Lys
210 215 220Leu Gln Ser Gln Ile Gln Ala Gln Glu Asp Ala Leu Lys Thr Phe Leu225 230 235 240Pro Leu Glu Lys Arg Leu Glu Thr Leu Lys Thr His Phe Leu Cys Asp
245 250 255Lys Glu Asn Leu Lys Ser Cys Ala Lys Glu Leu His Gln Arg Tyr Gln
260 265 270Asn Ala Leu Ile Glu Arg Asp Lys Glu Leu Lys Asn Ala Lys Asn Asn
275 280 285Lys Glu Lys His Ala Leu Ile Leu Ala Asn Tyr Glu His Thr Leu Lys
290 295 300Thr Leu Asn Ile Glu Phe Leu Ser Glu Leu Asn Lys Gln Met Ala Phe305 310 315 320Leu Asn Glu Thr Met Ala Leu Asn Ala Arg Val Leu Ala Leu Leu Ala
325 330 335Lys Gln His Ala Lys Thr Pro Lys Pro Phe Asn Leu Ser Gly Gly Leu
340345 350Ser Gly Asp Leu Ser Gly Gly Lys Ala Leu Ile Lys Asn Ile Arg Leu
355 360 365Asp Pro His Gly Phe Pro Ser Phe Lys Asn Phe Lys Gln Glu
370 375 380
(2) Sequence 225 data:
(i) sequence characteristics:
(A) length: 490bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...437
(D) Other information:
(xi) Description of the sequence: sequence 225: TTGTTGAGAA AATCCGATGT TTTGAGCGAA AAATTCAGGA TCATGAAAAA ATG AAA 56
Met Lys
1AGC ATC AGA AGA GGC GAT GGG CTG AAT GTT GTC CCT TTC ATT GAT ATT 104Ser Ile Arg Arg Gly Asp Gly Leu Asn Val Val Pro Phe Ile Asp Ile
5 10 15ATG CTC GTT TTG CTA GCG ATT GTG TTG AGC ATT TCT ACT TTT ATT GCA 152Met Leu Val Leu Leu Ala Ile Val Leu Ser Ile Ser Thr Phe Ile Ala
20 25 30CAA GGT AAG ATT AAG GTC AGT CTC CCT AAC GCT AAA AAT GCG GAA AAA 200Gln Gly Lys Ile Lys Val Ser Leu Pro Asn Ala Lys Asn Ala Glu Lys35 40 45 50TCC CAG CCA AAC GAT CAA AAA GTG GTG GTC ATC TCT GTA GAT GAG CAT 248Ser Gln Pro Asn Asp Gln Lys Val Val Val Ile Ser Val Asp Glu His
55 60 65GAC AAT ATT TTC GTA GAT GAC AAA CCG ATG AAT TTA GAA GCT TTG AGC 296Asp Asn Ile Phe Val Asp Asp Lys Pro Met Asn Leu Glu Ala Leu Ser
70 75 80GCT GTA GTC AAA CAA ACA GAC CCT AAA ACC CTT ATA GAC TTA AAA AGC 344Ala Val Val Lys Gln Thr Asp Pro Lys Thr Leu Ile Asp Leu Lys Ser
85 90 95GAC AAA AGC TCT CGT TTT GAA ACT TTT ATC AGC ATT ATG GAT ATT TTA 392Asp Lys Ser Ser Arg Phe Glu Thr Phe Ile Ser Ile Met Asp Ile Leu
100 105 110AAA GAG CAT AAT CAT GAA AAT TTC TCC ATC TCC ACG CAA GCT CAG TAAAG 442Lys Glu His Asn His Glu Asn Phe Ser Ile Ser Thr Gln Ala Gln115 120 125TTTCAACGAG TGTTAGCTTT TTAATCTCTT TTGCCCTATA CGCTATAG 490
(2) Sequence 226 data:
(i) sequence characteristics:
(A) length: 129 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 226: met Lys Ser Ile Arg Arg Gly Asp Gly Leu Asn Val Val Pro Phe Ile 151015 Asp Ile Met Leu Val Leu Leu Ala Ile Val Leu Ser Ile Ser Thr Phe
20 25 30Ile Ala Gln Gly Lys Ile Lys Val Ser Leu Pro Asn Ala Lys Asn Ala
35 40 45GluLys Ser Gln Pro Asn Asp Gln Lys Val Val Val Ile Ser Val Asp
50 55 60Glu His Asp Asn Ile Phe Val Asp Asp Lys Pro Met Asn Leu Glu Ala65 70 75 80Leu Ser Ala Val Val Lys Gln Thr Asp Pro Lys Thr Leu Ile Asp Leu
85 90 95Lys Ser Asp Lys Ser Ser Arg Phe Glu Thr Phe Ile Ser Ile Met Asp
100 105 110Ile Leu Lys Glu His Asn His Glu Asn Phe Ser Ile Ser Thr Gln Ala
115 120 125Gln
(2) Data in sequence 227:
(i) sequence characteristics:
(A) length: 958bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...905
(D) Other information:
(xi) Description of the sequence: sequence 227: TCGTTTTGAA ACTTTTATCA GCATTATGGA TATTTTAAAA GAGCATAATC ATG AAA 56
Met Lys
1ATT TCT CCA TCT CCA CGC AAG CTC AGT AAA GTT TCA ACG AGT GTT AGC 104Ile Ser Pro Ser Pro Arg Lys Leu Ser Lys Val Ser Thr Ser Val Ser
5 10 15TTT TTA ATC TCT TTT GCC CTA TAC GCT ATA GGG TTT GGC TAT TTT TTA 152Phe Leu Ile Ser Phe Ala Leu Tyr Ala Ile Gly Phe Gly Tyr Phe Leu
20 25 30CTG CGC GAA GAC GCC CCA GAG CCT TTA GCG CAA GCC GGG ACC ACT AAG 200Leu Arg Glu Asp Ala Pro Glu Pro Leu Ala Gln Ala Gly Thr Thr Lys35 40 45 50GTT ACC ATG AGT TTA GCC AGC ATC AAC ACT AAT TCC AAT ACA AAG ACT 248Val Thr Met Ser Leu Ala Ser Ile Asn Thr Asn Ser Asn Thr Lys Thr
55 60 65AAT GCT GAG TCG GCT AAA CCC AAA GAA GAG CCT AAA GAA AAA CCC AAG 296Asn Ala Glu Ser Ala Lys Pro Lys Glu Glu Pro Lys Glu Lys Pro Lys
70 75 80AAA GAA GAG CCA AAA AAA GAA GAA CCC AAA AAG GAG GTT ACA AAG CCT 344Lys Glu Glu Pro Lys Lys Glu Glu Pro Lys Lys Glu Val Thr Lys Pro
85 90 95AAA CCT AAG CCT AAA CCC AAG CCA AAG CCA AAA CCA AAA CCT AAG CCT 392Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro
100 105 110GAA CCC AAA CCT GAA CCA AAA CCC GAG CCT AAG CCT GAG CCT AAA GTT 440Glu Pro Lys Pro Glu Pro Lys Pro Glu Pro Lys Pro Glu Pro Lys Val115 120 125 130GAA GAG GTT AAA AAA GAA GAG CCT AAA GAA GAG CCC AAA AAA GAA GAA 488Glu Glu Val Lys Lys Glu Glu Pro Lys Glu Glu Pro Lys Lys Glu Glu
135 140 145GCT AAA GAG GAA GCT AAA GAA AAA AGC GCT CCT AAA CAA GTA ACA ACT 536Ala Lys Glu Glu Ala Lys Glu Lys Ser Ala Pro Lys Gln Val Thr Thr
150 155 160AAG GAT ATA GTC AAA GAA AAA GAC AAG CAA GAA GAA TCC AAC AAA ACC 584Lys Asp Ile Val Lys Glu Lys Asp Lys Gln Glu Glu Ser Asn Lys Thr
165170 175TCT GAG GGG GCC ACT TCT GAA GCT CAA GCT TAT AAC CCA GGG GTG AGC 632Ser Glu Gly Ala Thr Ser Glu Ala Gln Ala Tyr Asn Pro Gly Val Ser
180 185 190AAC GAA TTT TTA ATG AAG ATC CAA ACC GCT ATT TCT TCT AAA AAC CGC 680Asn Glu Phe Leu Met Lys Ile Gln Thr Ala Ile Ser Ser Lys Asn Arg195 200 205 210TAC CCT AAA ATG GCG CAG ATT AGG GGT ATT GAG GGC GAA GTG TTG GTG 728Tyr Pro Lys Met Ala Gln Ile Arg Gly Ile Glu Gly Glu Val Leu Val
215 220 225AGC TTT ACG ATC AAT GCT GAT GGG AGC GTT ACG GAC ATT AAA GTG GTC 776Ser Phe Thr Ile Asn Ala Asp Gly Ser Val Thr Asp Ile Lys Val Val
230 235 240AAA AGC AAC ACC ACA GAT ATT TTA AAC CAT GCG GCT TTA GAA GCC ATT 824Lys Ser Asn Thr Thr Asp Ile Leu Asn His Ala Ala Leu Glu Ala Ile
245 250 255AAA AGC GCG GCA CAT CTA TTC CCT AAA CCA GAA GAA ACC GTG CAT CTA 872Lys Ser Ala Ala His Leu Phe Pro Lys Pro Glu Glu Thr Val His Leu
260 265 270AAA ATC CCT ATC GCT TAT AGC TTG AAA GAA GAC TGATTAGTCT TTCTTTTAGG 925Lys Ile Pro Ile Ala Tyr Ser Leu Lys Glu Asp275 280 285GGCGATTCAA GCCTTAAAAG CCGGGTCAAA ATC 958
(2) Sequence 228 data:
(i) sequence characteristics:
(A) length: 285 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 228: met Lys Ile Ser Pro Ser Pro Arg Lys Leu Ser Lys Val Ser Thr Ser 151015 Val Ser Phe Leu Ile Ser Phe Ala Leu Tyr Ala Ile Gly Phe Gly Tyr
20 25 30Phe Leu Leu Arg Glu Asp Ala Pro Glu Pro Leu Ala Gln Ala Gly Thr
35 40 45Thr Lys Val Thr Met Ser Leu Ala Ser Ile Asn Thr Asn Ser Asn Thr
50 55 60Lys Thr Asn Ala Glu Ser Ala Lys Pro Lys Glu Glu Pro Lys Glu Lys65 70 75 80Pro Lys Lys Glu Glu Pro Lys Lys Glu Glu Pro Lys Lys Glu Val Thr
85 90 95Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro
100 105 110Lys Pro Glu Pro Lys Pro Glu Pro Lys Pro Glu Pro Lys Pro Glu Pro
115 120 125Lys Val Glu Glu Val Lys Lys Glu Glu Pro Lys Glu Glu Pro Lys Lys
130 135 140Glu Glu Ala Lys Glu Glu Ala Lys Glu Lys Ser Ala Pro Lys Gln Val145 150 155 160Thr Thr Lys Asp Ile Val Lys Glu Lys Asp Lys Gln Glu Glu Ser Asn
165 170 175Lys Thr Ser Glu Gly Ala Thr Ser Glu Ala Gln Ala Tyr Asn Pro Gly
180 185 190Val Ser Asn Glu Phe Leu Met Lys Ile Gln Thr Ala Ile Ser Ser Lys
195 200 205Asn Arg Tyr Pro Lys Met Ala Gln Ile Arg Gly Ile Glu Gly Glu Val
210 215 220Leu Val Ser Phe Thr Ile Asn Ala Asp Gly Ser Val Thr Asp Ile Lys225 230 235 240Val Val Lys Ser Asn Thr Thr Asp Ile Leu Asn His Ala Ala Leu Glu
245 250 255Ala Ile Lys Ser Ala Ala His Leu Phe Pro Lys Pro Glu Glu Thr Val
260 265 270His Leu Lys Ile Pro Ile Ala Tyr Ser Leu Lys Glu Asp
275 280 285
(2) Sequence 229 data:
(i) sequence characteristics:
(A) length: 757bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...704
(D) Other information:
(xi) Description of the sequence: sequence 229: TTGATGAAAA AAATAACGCT CCTCTTTTTA AAACTCTTTT AGAGGATGCC ATG AGA 56
Met Arg
1GTG TCT TCT AAA GAG ATT TTA CTC ATT GTG GGG GGG AGC AGT TTT TAC 104Val Ser Ser Lys Glu Ile Leu Leu Ile Val Gly Gly Ser Ser Phe Tyr
5 10 15CTC AAA TCC ATT TTA GAA GGT TTG AGC CGC ATG CCA AAA CTG AGC GGT 152Leu Lys Ser Ile Leu Glu Gly Leu Ser Arg Met Pro Lys Leu Ser Gly
20 2530GAG GAG GTT GTA AAA ATA GAG CGA GAA ATT GCC ACT CTT TCT AAC CCT 200Glu Glu Val Val Lys Ile Glu Arg Glu Ile Ala Thr Leu Ser Asn Pro35 40 45 50TAT ATA TTT TTA AAA TCC ATT GAC CCT AAC ATG GCT TTT AAA ATC CAT 248Tyr Ile Phe Leu Lys Ser Ile Asp Pro Asn Met Ala Phe Lys Ile His
55 60 65CCA AAC GAC ACT TAC CGC ACC CAT AAG GCT TTA GAA ATC TTT TAT GCC 296Pro Asn Asp Thr Tyr Arg Thr His Lys Ala Leu Glu Ile Phe Tyr Ala
70 75 80ACC TGC ACG CCC CCA AGC GAG TAT TTT AAG GCC AAC CCT AAA AAA CCC 344Thr Cys Thr Pro Pro Ser Glu Tyr Phe Lys Ala Asn Pro Lys Lys Pro
85 90 95TTT GAG CAT GCT ATC TCC TTA TTC GCT CTG TCT ATT GAA AAA AGC GCG 392Phe Glu His Ala Ile Ser Leu Phe Ala Leu Ser Ile Glu Lys Ser Ala
100 105 110CTC CAT AAC AAT ATC AAA CGG CGC ACC AAA AAC ATG CTC CAT TCA GGG 440Leu His Asn Asn Ile Lys Arg Arg Thr Lys Asn Met Leu His Ser Gly115 120 125 130CTT GTT GAA GAA ATC AAA GCC CTC TAT ACT CAA TAC CCT AAA GAT TCG 488Leu Val Glu Glu Ile Lys Ala Leu Tyr Thr Gln Tyr Pro Lys Asp Ser
135 140 145CAG CCT TTT AAA GCC ATA GGC GTT AAA GAG AGC GTT CTT TTT TTA GAA 536Gln Pro Phe Lys Ala Ile Gly Val Lys Glu Ser Val Leu Phe Leu Glu
150 155 160AAA CGA CTC ACT TTA AAG GAG CTA GAA GAA GCG ATT ACC TCT AAC ACC 584Lys Arg Leu Thr Leu Lys Glu Leu Glu Glu Ala Ile Thr Ser Asn Thr
165 170 175ATG AAA TTA GCC AAG CGC CAA AAC ACT TTC AAT AAA ACC CAA TTC AAT 632MetLys Leu Ala Lys Arg Gln Asn Thr Phe Asn Lys Thr Gln Phe Asn
180 185 190AAC CTT TAT GTG GGG AGC GCT GAA GAA GTT AGG CAT GCG ATT TTA AAA 680Asn Leu Tyr Val Gly Ser Ala Glu Glu Val Arg His Ala Ile Leu Lys195 200 205 210CAC TCA AAA AGC GGC ATT AAA GGA TAATCTAATG GATACACAAA ACTTACCCGA 734His Ser Lys Ser Gly Ile Lys Gly
215TCAAATTATC CCTATTTTTA TGA 757
(2) Sequence 230 data:
(i) sequence characteristics:
(A) length: 218 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 230: met Arg Val Ser Ser Lys Glu Ile Leu Leu Ile Val Gly Gly Ser Ser 151015 Phe Tyr Leu Lys Ser Ile Leu Glu Gly Leu Ser Arg Met Pro Lys Leu
20 25 30Ser Gly Glu Glu Val Val Lys Ile Glu Arg Glu Ile Ala Thr Leu Ser
35 40 45Asn Pro Tyr Ile Phe Leu Lys Ser Ile Asp Pro Asn Met Ala Phe Lys
50 55 60Ile His Pro Asn Asp Thr Tyr Arg Thr His Lys Ala Leu Glu Ile Phe65 70 75 80Tyr Ala Thr Cys Thr Pro Pro Ser Glu Tyr Phe Lys Ala Asn Pro Lys
85 90 95Lys Pro Phe Glu His Ala Ile Ser Leu Phe Ala Leu Ser Ile Glu Lys
100 105 110Ser Ala Leu His Asn Asn Ile Lys Arg Arg Thr Lys Asn Met Leu His
115 120 125Ser Gly Leu Val Glu Glu Ile Lys Ala Leu Tyr Thr Gln Tyr Pro Lys
130 135 140Asp Ser Gln Pro Phe Lys Ala Ile Gly Val Lys Glu Ser Val Leu Phe145 150 155 160Leu Glu Lys Arg Leu Thr Leu Lys Glu Leu Glu Glu Ala Ile Thr Ser
165 170 175Asn Thr Met Lys Leu Ala Lys Arg Gln Asn Thr Phe Asn Lys Thr Gln
180 185 190Phe Asn Asn Leu Tyr Val Gly Ser Ala Glu Glu Val Arg His Ala Ile
195 200 205Leu Lys His Ser Lys Ser Gly Ile Lys Gly
210 215
(2) Sequence 231 data:
(i) sequence characteristics:
(A) length: 454bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...401
(D) Other information:
(xi) Description of the sequence: sequence 231: CTATATGAAC AAAGCCTTAA AAGACTTGAA AAAAGGAATA ACTCATACCT ATG CGA 56
Met Arg
1AAC AAT AAA ACG CCT TTT TTG AGC GCG ATT TTT ACG GCA TCA ATT AGG 104Asn Asn Lys Thr Pro Phe Leu Ser Ala Ile Phe Thr Ala Ser Ile Arg
5 10 15GGT TAC CAA CGC TTT TTT TCG GCT TTC ACC CCT TCA AGC TGC CGG TTT 152Gly Tyr Gln Arg Phe Phe Ser Ala Phe Thr Pro Ser Ser Cys Arg Phe
20 25 30TAC CCC ACT TGT TCC AAC TAC GCT CTG TGG TTG CTC TGT TTT GAA AGC 200Tyr Pro Thr Cys Ser Asn Tyr Ala Leu Trp Leu Leu Cys Phe Glu Ser35 40 45 50CCT TTG AGC GCT ATG GGT AAG ATC GCT ATA AGG ATA CTC TCA TGC AAC 248Pro Leu Ser Ala Met Gly Lys Ile Ala Ile Arg Ile Leu Ser Cys Asn
55 60 65CCT TTT TGC TCT GGG GGC ATT GCT TAC CCT ACT ACT CGC TTG AAA CGC 296Pro Phe Cys Ser Gly Gly Ile Ala Tyr Pro Thr Thr Arg Leu Lys Arg
70 75 80CCA AGC CTG ATC CAA TCT CAT AAA GAT TCT AAT CGC AAT TTT AAA ACC 344Pro Ser Leu Ile Gln Ser His Lys Asp Ser Asn Arg Asn Phe Lys Thr
85 90 95ATC ACT TTT TGG CTC GTT CCC ACA AAA AGC CAC GCA ACT TAC TAC ATC 392Ile Thr Phe Trp Leu Val Pro Thr Lys Ser His Ala Thr Tyr Tyr Ile
100 105 110ATT AAG GTT TAATCACAAT GGATAAAAAC AACAATAATC TCCGCTTGAT TTTAGCGAT 450Ile Lys Val115CGCT 454
(2) Sequence 232 data:
(i) sequence characteristics:
(A) length: 117 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 232: met Arg Asn Asn Lys Thr Pro Phe Leu Ser Ala Ile Phe Thr Ala Ser 151015 Ile Arg Gly Tyr Gln Arg Phe Phe Ser Ala Phe Thr Pro Ser Ser Cys
20 25 30Arg Phe Tyr Pro Thr Cys Ser Asn Tyr Ala Leu Trp Leu Leu Cys Phe
35 40 45Glu Ser Pro Leu Ser Ala Met Gly Lys Ile Ala Ile Arg Ile Leu Ser
50 55 60Cys Asn Pro Phe Cys Ser Gly Gly Ile Ala Tyr Pro Thr Thr Arg Leu65 70 75 80Lys Arg Pro Ser Leu Ile Gln Ser His Lys Asp Ser Asn Arg Asn Phe
85 90 95Lys Thr Ile Thr Phe Trp Leu Val Pro Thr Lys Ser His Ala Thr Tyr
100 105 110Tyr Ile Ile Lys Val
115
(2) Data for sequence 233:
(i) sequence characteristics:
(A) length: 1153bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1100
(D) Other information:
(xi) Description of the sequence: sequence 233: TTATAATAAG AAAGTTTTTA TTATTTTTAA TGCTATTTTA GGAGTTCATC ATG AAA 56
Met Lys
1AAA TCC ATT TTA TTG GGC GTT TGC TTG GCT TTT TCT TGC GCT CAT GCC 104Lys Ser Ile Leu Leu Gly Val Cys Leu Ala Phe Ser Cys Ala His Ala
5 10 15CTA AAC GAT TTA GAA TTG ATC AAA AAA GCG AGG GAA AGC CAG CTA GAA 152Leu Asn Asp Leu Glu Leu Ile Lys Lys Ala Arg Glu Ser Gln Leu Glu
20 25 30CCC ATG CCT ATG GGC AAA GCG CTC AAA GAA TAC CAG ATT AAA AAG ACC 200Pro Met Pro Met Gly Lys Ala Leu Lys Glu Tyr Gln Ile Lys Lys Thr35 40 45 50AGA GAT GTG GGT ATT GGC ACC AAA AAC AGC GAA ATC ATG ACC TCC GCT 248Arg Asp Val Gly Ile Gly Thr Lys Asn Ser Glu Ile Met Thr Ser Ala
55 60 65CAA GTG GAA TTA GGC AAA ATG GTC TAT TTT GAC CCT AGG ATT TCC ACT 296Gln Val Glu Leu Gly Lys Met Leu Tyr Phe Asp Pro Arg Ile Ser Thr
70 75 80TCC TAC CTC GTG TCT TGC AAC ACA TGC CAT AAT CTG GGC TTA GGC GGG 344Ser Tyr Leu Val Ser Cys Asn Thr Cys His Asn Leu Gly Leu Gly Gly
85 90 95GTG GAT TTA GTC CCA AGC GCC ATA GGC TCT CAA TGG AAG AAA AAC CCC 392Val Asp Leu Val Pro Ser Ala Ile Gly Ser Gln Trp Lys Lys Asn Pro
100 105 110CAC CTT TTA AGC TCC CCA ACG GTG TAT AAC TCT GTG TTT AAC GAT GTG 440His Leu Leu Ser Ser Pro Thr Val Tyr Asn Ser Val Phe Asn Asp Val115 120 125 130CAG TTT TGG GAT GGC AGG GTT ACG CAT TTA AAC GAA CAG GCG CAA GGG 488Gln Phe Trp Asp Gly Arg Val Thr His Leu Asn Glu Gln Ala Gln Gly
135 140 145CCC ATC CAG TCT TCT TTT GAA ATG GGG GCT GAT CCC AAA GTG GTG GTA 536Pro Ile Gln Ser Ser Phe Glu Met Gly Ala Asp Pro Lys Val Val Val
150 155 160GAA AAA ATC AAT TCC ATG CCA GGC TAT GTC AAG CTC TTT AGA AAA GCC 584Glu Lys Ile Asn Ser Met Pro Gly Tyr Val Lys Leu Phe Arg Lys Ala
165 170 175TAT GGC TCT AAA GTC AAA ATT GAT TTT AAA TTG ATC GCT GAT AGT ATC 632Tyr Gly Ser Lys Val Lys Ile Asp Phe Lys Leu Ile Ala Asp Ser Ile
180 185 190GCT ATG TTT GAA GCC ACG CTT ATT ACC CCA AGC CGT TAC GAC GAT TTT 680Ala Met Phe Glu Ala Thr Leu Ile Thr Pro Ser Arg Tyr Asp Asp Phe195 200 205 210TTA AGA GGC AAT CCT AAA GCG CTC AGC AAA GCC GAA AAA GAG GGG CTG 728Leu Arg Gly Asn Pro Lys Ala Leu Ser Lys Ala Glu Lys Glu Gly Leu
215 220 225AAT TTA TTC ATT TCT AAA GGC TGT GTG GCT TGC CAT AAC GGC ATT AAT 776Asn Leu Phe Ile Ser Lys Gly Cys Val Ala Cys His Asn Gly Ile Asn
230 235 240CTT GGG GGA ACG ATG CAG CCT TTT GGG GTG GTC AAA CCT TAT AAA TTC 824Leu Gly Gly Thr Met Gln Pro Phe Gly Val Val Lys Pro Tyr Lys Phe
245 250 255GCT AAT GTG GGC GAT TTC AAA GGC GAT AAA AAC GGG CTT GTG AAA GTG 872Ala Asn Val Gly Asp Phe Lys Gly Asp Lys Asn Gly Leu Val Lys Val
260 265 270CCT ACT TTA AGG AAT ATC ACC GAA ACG ATG CCC TAT TTC CAT AAC GGG 920Pro Thr Leu Arg Asn Ile Thr Glu Thr Met Pro Tyr Phe His Asn Gly275280 285 290CAA TTC TGG GAT GTT AAG GAT GCG ATT AAA GAA ATG GGC TCT ATC CAG 968Gln Phe Trp Asp Val Lys Asp Ala Ile Lys Glu Met Gly Ser Ile Gln
295 300 305TTA GGC ATT GAA ATC AGC GAT GAA GAA GCG AAA AAA ATT GAA ACT TTC 1016Leu Gly Ile Glu Ile Ser Asp Glu Glu Ala Lys Lys Ile Glu Thr Phe
310 315 320TTT GGA GCC TTA AGG GGT AAA AAA CCT AAA ATA ATC TAC CCA GAA CTC 1064Phe Gly Ala Leu Arg Gly Lys Lys Pro Lys Ile Ile Tyr Pro Glu Leu
325 330 335CCC ATA ATG ACA GAC AAA ACC CCT AAA CCC TCT TTT TGATTTAAAA AAGTCC 1116Pro Ile Met Thr Asp Lys Thr Pro Lys Pro Ser Phe
340 345 350TTTTAGGGGT CTTTGGCGCT AAATCTAAAA AATACTC 1153
(2) Sequence 234 data:
(i) sequence characteristics:
(A) length: 350 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 234: met Lys Lys Ser Ile Leu Leu Gly Val Cys Leu Ala Phe Ser Cys Ala 151015 His Ala Leu Asn Asp Leu Glu Leu Ile Lys Lys Ala Arg Glu Ser Gln
20 25 30Leu Glu Pro Met Pro Met Gly Lys Ala Leu Lys Glu Tyr Gln Ile Lys
35 40 45Lys Thr Arg Asp Val Gly Ile Gly Thr Lys Asn Ser Glu Ile Met Thr
50 55 60Ser Ala Gln Val Glu Leu Gly Lys Met Leu Tyr Phe Asp Pro Arg Ile65 70 75 80Ser Thr Ser Tyr Leu Val Ser Cys Asn Thr Cys His Asn Leu Gly Leu
85 90 95Gly Gly Val Asp Leu Val Pro Ser Ala Ile Gly Ser Gln Trp Lys Lys
100 105 110Asn Pro His Leu Leu Ser Ser Pro Thr Val Tyr Asn Ser Val Phe Asn
115 120 125Asp Val Gln Phe Trp Asp Gly Arg Val Thr His Leu Asn Glu Gln Ala
130 135 140Gln Gly Pro Ile Gln Ser Ser Phe Glu Met Gly Ala Asp Pro Lys Val145 150 155 160Val Val Glu Lys Ile Asn Ser Met Pro Gly Tyr Val Lys Leu Phe Arg
165 170 175Lys Ala Tyr Gly Ser Lys Val Lys Ile Asp Phe Lys Leu Ile Ala Asp
180 185 190Ser Ile Ala Met Phe Glu Ala Thr Leu Ile Thr Pro Ser Arg Tyr Asp
195 200 205Asp Phe Leu Arg Gly Asn Pro Lys Ala Leu Ser Lys Ala Glu Lys Glu
210 215 220Gly Leu Asn Leu Phe Ile Ser Lys Gly Cys Val Ala Cys His Asn Gly225 230 235 240Ile Asn Leu Gly Gly Thr Met Gln Pro Phe Gly Val Val Lys Pro Tyr
245 250 255Lys Phe Ala Asn Val Gly Asp Phe Lys Gly Asp Lys Asn Gly Leu Val
260 265 270Lys Val Pro Thr Leu Arg Asn Ile Thr Glu Thr Met Pro Tyr Phe His
275 280 285Asn Gly Gln Phe Trp Asp Val Lys Asp Ala Ile Lys Glu Met Gly Ser
290 295 300Ile Gln Leu Gly Ile Glu Ile Ser Asp Glu Glu Ala Lys Lys Ile Glu305 310 315 320Thr Phe Phe Gly Ala Leu Arg Gly Lys Lys Pro Lys Ile Ile Tyr Pro
325 330 335Glu Leu Pro Ile Met Thr Asp Lys Thr Pro Lys Pro Ser Phe
340 345 350
(2) Sequence 235 data:
(i) sequence characteristics:
(A) length: 426bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...374
(D) Other information:
(xi) Description of the sequence: sequence 235: GTTAGAGATT TCTCCCAATT CTCAAGTGGG AGCGAGCGTG AAAATCCGCT ATG AAA 56
Met Lys
1GCA ATC TTT AGC CTC TTT TTC CTT CTT ATT GTT TTA AAA GCA AAC CCC 104Ala Ile Phe Ser Leu Phe Phe Leu Leu Ile Val Leu Lys Ala Asn Pro
5 10 15ATA AAC CCT TTA TTA GAG CCG TTA TAT TTC CCC AGT TAC GCG CAA TTT 152Ile Asn Pro Leu Leu Glu Pro Leu Tyr Phe Pro Ser Tyr Ala Gln Phe
20 25 30TTA AAC TTA GCA CCT CAC TTT GTC ATT AAA AAA AAG CGC GCT TAT AGA 200Leu Asn Leu Ala Pro His Phe Val Ile Lys Lys Lys Arg Ala Tyr Arg35 40 45 50CCC TTT CAA TGG GGG AAT ACC ATT ATC ATC AAA CGC CAT GAT TTA GAA 248Pro Phe Gln Trp Gly Asn Thr Ile Ile Ile Lys Arg His Asp Leu Glu
55 60 65GAA CGC CAA AGC AAC CAG CCA AGC GAT ATT TTC CGC CAA AAC GCT GAA 296Glu Arg Gln Ser Asn Gln Pro Ser Asp Ile Phe Arg Gln Asn Ala Glu
70 75 80ATC AAT GTG TCT TCT CAA ACT TTT TTA AAA GGA ATG AGC AAC GCT TCT 344Ile Asn Val Ser Ser Gln Thr Phe Leu Lys Gly Met Ser Asn Ala Ser
85 90 95TCA CGA ACA GTG CTT GAT TCA GCC GCT CAG TAAAATGCTA AAACTTTTTT TAA 397Ser Arg Thr Val Leu Asp Ser Ala Ala Gln
100 105TCACATTTTT CTTGGTATTT TCTTAATCC 426
(2) Sequence 236 data:
(i) sequence characteristics:
(A) length: 108 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 236: met Lys Ala Ile Phe Ser Leu Phe Phe Leu Leu Ile Val Leu Lys Ala 151015 Asn Pro Ile Asn Pro Leu Leu Glu Pro Leu Tyr Phe Pro Ser Tyr Ala
20 25 30Gln Phe Leu Asn Leu Ala Pro His Phe Val Ile Lys Lys Lys Arg Ala
35 40 45Tyr Arg Pro Phe Gln Trp Gly Asn Thr Ile Ile Ile Lys Arg His Asp
50 55 60Leu Glu Glu Arg Gln Ser Asn Gln Pro Ser Asp Ile Phe Arg Gln Asn65 70 75 80Ala Glu Ile Asn Val Ser Ser Gln Thr Phe Leu Lys Gly Met Ser Asn
85 90 95Ala Ser Ser Arg Thr Val Leu Asp Ser Ala Ala Gln
100 105
(2) Sequence 237 data:
(i) sequence characteristics:
(A) length: 799bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...746
(D) Other information:
(xi) Description of the sequence: sequence 237: AGCGTGAGCC CAATTACGCC ACGCCTATGT CTAGATAGGG GAGGTTGGAA ATG TTT 56
Met Phe
1AGT TTT TTA GAA AAA AAC CCG TTC TTT TTC ACT CTT GCG TTT ATT TTT 104Ser Phe Leu Glu Lys Asn Pro Phe Phe Phe Thr Leu Ala Phe Ile Phe
5 10 15GTG TTT GCG ATC GCG GGC TTG GTG GAG ATT TTG CCC AAC TTC TTC AAA 152Val Phe Ala Ile Ala Gly Leu Val Glu Ile Leu Pro Asn Phe Phe Lys
20 25 30TCC GCT CGC CCG ATT GAA GGC TTA CGG CCT TAT ACG GTT TTA GAG ACA 200Ser Ala Arg Pro Ile Glu Gly Leu Arg Pro Tyr Thr Val Leu Glu Thr35 40 45 50GCG GGG AGG CAA ATT TAT ATC CAA GAA GGT TGC TAT CAT TGC CAT TCC 248Ala Gly Arg Gln Ile Tyr Ile Gln Glu Gly Cys Tyr His Cys His Ser
55 60 65CAG CTT ATT CGC CCT TTC CAA GCT GAG GTG GAT CGA TAT GGC GCG TAT 296Gln Leu Ile Arg Pro Phe Gln Ala Glu Val Asp Arg Tyr Gly Ala Tyr
70 75 80AGT TTG AGT GGG GAA TAC GCG TAT GAC AGG CCA TTT TTG TGG GGT TCT 344Ser Leu Ser Gly Glu Tyr Ala Tyr Asp Arg Pro Phe Leu Trp Gly Ser
85 90 95AAA AGG ATT GGC CCT GAT TTG CAC AGG GTA GGG GAT TAT CGC ACA ACC 392Lys Arg Ile Gly Pro Asp Leu His Arg Val Gly Asp Tyr Arg Thr Thr
100 105 110GAT TGG CAT GAA AAG CAC ATG TTT GAT CCT AAA AGC GTT GTG CCG CAC 440Asp Trp His Glu Lys His Met Phe Asp Pro Lys Ser Val Val Pro His115 120 125 130AGC ATC ATG CCC GCC TAT AAG CAT TTA TTT ACA AAA AAG AGC GAT TTT 488Ser Ile Met Pro Ala Tyr Lys His Leu Phe Thr Lys Lys Ser Asp Phe
135 140 145GAC ACC GCT TAT GCA GAA GCT TTG ACG CAA AAA AAG GTT TTT GGC GTG 536Asp Thr Ala Tyr Ala Glu Ala Leu Thr Gln Lys Lys Val Phe Gly Val
150 155 160CCT TAT GAC ACA GAA AAC GGC GTG AAA TTA GGG AGC GTA GAA GAA GCG 584Pro Tyr Asp Thr Glu Asn Gly Val Lys Leu Gly Ser Val Glu Glu Ala
165 170 175AAA AAA GCC TAT TTA GAA GAA GCT AAA AAA ATC ACA GCC GAT ATG AAA 632LysLys Ala Tyr Leu Glu Glu Ala Lys Lys Ile Thr Ala Asp Met Lys
180 185 190GAC AAG AGG GTG CTA GAA GCG ATT GAG AGA GGT GAA GTG TTA GAA ATT 680Asp Lys Arg Val Leu Glu Ala Ile Glu Arg Gly Glu Val Leu Glu Ile195 200 205 210GTG GCT TTG ATC GCT TAT TTG AAT AGC TTG GGT AAT TCC AGG ATC AAC 728Val Ala Leu Ile Ala Tyr Leu Asn Ser Leu Gly Asn Ser Arg Ile Asn
215 220 225GCC AAT CAA AAC GCT AAA TAAGGGGTGA ATGATGGATT TAGAAAGTTT GAGAGGTT 784Ala Asn Gln Asn Ala Lys
230TTGCGTATGC GTTTT 799
(2) Sequence 238 data:
(i) sequence characteristics:
(A) length: 232 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 238: met Phe Ser Phe Leu Glu Lys Asn Pro Phe Phe Phe Thr Leu Ala Phe 151015 Ile Phe Val Phe Ala Ile Ala Gly Leu Val Glu Ile Leu Pro Asn Phe
20 25 30Phe Lys Ser Ala Arg Pro Ile Glu Gly Leu Arg Pro Tyr Thr Val Leu
35 40 45Glu Thr Ala Gly Arg Gln Ile Tyr Ile Gln Glu Gly Cys Tyr His Cys
50 55 60His Ser Gln Leu Ile Arg Pro Phe Gln Ala Glu Val Asp Arg Tyr Gly65 70 75 80Ala Tyr Ser Leu Ser Gly Glu Tyr Ala Tyr Asp Arg Pro Phe Leu Trp
85 90 95Gly Ser Lys Arg Ile Gly Pro Asp Leu His Arg Val Gly Asp Tyr Arg
100 105 110Thr Thr Asp Trp His Glu Lys His Met Phe Asp Pro Lys Ser Val Val
115 120 125Pro His Ser Ile Met Pro Ala Tyr Lys His Leu Phe Thr Lys Lys Ser
130 135 140Asp Phe Asp Thr Ala Tyr Ala Glu Ala Leu Thr Gln Lys Lys Val Phe145 150 155 160Gly Val Pro Tyr Asp Thr Glu Asn Gly Val Lys Leu Gly Ser Val Glu
165 170 175Glu Ala Lys Lys Ala Tyr Leu Glu Glu Ala Lys Lys Ile Thr Ala Asp
180 185 190Met Lys Asp Lys Arg Val Leu Glu Ala Ile Glu Arg Gly Glu Val Leu
195 200 205Glu Ile Val Ala Leu Ile Ala Tyr Leu Asn Ser Leu Gly Asn Ser Arg
210 215 220Ile Asn Ala Asn Gln Asn Ala Lys225 230
(2) Sequence 239 data:
(i) sequence characteristics:
(A) length: 322bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...269
(D) Other information:
(xi) Description of the sequence: sequence 239: CTTGGGTAAT TCCAGGATCA ACGCCAATCA AAACGCTAAA TAAGGGGTGA ATG ATG 56
Met Met
1GAT TTA GAA AGT TTG AGA GGT TTT GCG TAT GCG TTT TTT ACC ATT CTT 104Asp Leu Glu Ser Leu Arg Gly Phe Ala Tyr Ala Phe Phe Thr Ile Leu
5 10 15TTT ACG CTC TTT TTG TAT GCC TAT ATT TTT AGC ATG TAT AGA AAG CAA 152Phe Thr Leu Phe Leu Tyr Ala Tyr Ile Phe Ser Met Tyr Arg Lys Gln
20 25 30AAA AAA GGC ATT ATG GAT TAT GAG CGA TAC GGA TAC TTA GCG TTA AAT 200Lys Lys Gly Ile Met Asp Tyr Glu Arg Tyr Gly Tyr Leu Ala Leu Asn35 40 45 50GAT GCT TTA GAA GAC GAG TTG ATT GAA CCA CGC CAT AAA AAA GTT CAT 248Asp Ala Leu Glu Asp Glu Leu Ile Glu Pro Arg His Lys Lys Val His
55 60 65GAT AAT GGC ATA AAG GAA AGT TGAAATGGAT TTTTTAAACG ACCATATAAA TGTT 303Asp Asn Gly Ile Lys Glu Ser
70TTTGGCTTGA TTGCAGCGC 322
(2) Sequence 240 data:
(i) sequence characteristics:
(A) length: 73 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 240: met Met Asp Leu Glu Ser Leu Arg Gly PheAla Tyr Ala Phe Phe Thr 151015 Ile Leu Phe Thr Leu Phe Leu Tyr Ala Tyr Ile Phe Ser Met Tyr Arg
20 25 30Lys Gln Lys Lys Gly Ile Met Asp Tyr Glu Arg Tyr Gly Tyr Leu Ala
35 40 45Leu Asn Asp Ala Leu Glu Asp Glu Leu Ile Glu Pro Arg His Lys Lys
50 55 60Val His Asp Asn Gly Ile Lys Glu Ser65 70
(2) Data of sequence 241:
(i) sequence characteristics:
(A) length: 1021bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...968
(D) Other information:
(xi) Description of the sequence: sequence 241: TTACTGATTT TTCTTTGTGT GAGCTTTGGC TTAGTTTTGT AAGGAATGAG ATG ATA 56
Met Ile
1AAG AGT TGG ACT AAA AAG TGG TTT TTG ATT TTA TTT TTA ATG GCA AGT 104Lys Ser Trp Thr Lys Lys Trp Phe Leu Ile Leu Phe Leu Met Ala Ser
5 10 15TGT TCC AGT TAT TTG GTG GCT ACA ACC GGT GAG AAA TAT TTT AAA ATG 152Cys Ser Ser Tyr Leu Val Ala Thr Thr Gly Glu Lys Tyr Phe Lys Met
20 25 30GCT ACT CAA GCC TTT AAG AGA GGG GAC TACCAT AAA GCG GTG GCT TTT 200Ala Thr Gln Ala Phe Lys Arg Gly Asp Tyr His Lys Ala Val Ala Phe35 40 45 50TAT AAG AGG AGC TGT AAT TTA AGG GTG GGG GTT GGT TGC ACG AGT TTA 248Tyr Lys Arg Ser Cys Asn Leu Arg Val Gly Val Gly Cys Thr Ser Leu
55 60 65GGC TCT ATG TAT GAA GAT GGC GAT GGC GTG GAT CAG AAT ATT ACA AAA 296Gly Ser Met Tyr Glu Asp Gly Asp Gly Val Asp Gln Asn Ile Thr Lys
70 75 80GCC GTT TTT TAT TAC AGA AGA GGG TGT AAT TTA AGG AAT CAT CTC GCT 344Ala Val Phe Tyr Tyr Arg Arg Gly Cys Asn Leu Arg Asn His Leu Ala
85 90 95TGC GCG AGT CTA GGC TCT ATG TAT GAA GAT GGC GAT GGT GTG CAA AAA 392Cys Ala Ser Leu Gly Ser Met Tyr Glu Asp Gly Asp Gly Val Gln Lys
100 105 110AAC CTT CCA AAG GCT ATC TAT TAT TAC AGG AGA GGG TGC CAC TTA AAG 440Asn Leu Pro Lys Ala Ile Tyr Tyr Tyr Arg Arg Gly Cys His Leu Lys115 120 125 130GGT GGG GTG AGC TGT GGG AGT TTA GGT TTT ATG TAT TTT AAT GGC ACG 488Gly Gly Val Ser Cys Gly Ser Leu Gly Phe Met Tyr Phe Asn Gly Thr
135 140 145GGC GTT AAG CAA AAT TAT GCC AAA GCC CTT TTT CTT TCT AAA TAC GCT 536Gly Val Lys Gln Asn Tyr Ala Lys Ala Leu Phe Leu Ser Lys Tyr Ala
150 155 160TGC AGT TTG AAT TAC GGC ATT AGT TGT AAC TTT GTA GGG TAT ATG TAT 584Cys Ser Leu Asn Tyr Gly Ile Ser Cys Asn Phe Val Gly Tyr Met Tyr
165 170 175AGG AAC GCC AAA GGC GTA CAG AAG GAT TTG AAA AAA GCC CTT GCG AAT 632Arg Asn Ala Lys Gly Val Gln Lys Asp Leu Lys Lys Ala Leu Ala Asn
180 185 190TTT AAA AGA GGG TGC CAT TTG AAA GAC GGA GCG AGT TGT GTG AGC TTG 680Phe Lys Arg Gly Cys His Leu Lys Asp G1y Ala Ser Cys Val Ser Leu195 200 205 210GGA TAC ATG TAT GAA GTC GGT ATG GAT GTC AAA CAA AAT GGA GAG CAA 728Gly Tyr Met Tyr Glu Val Gly Met Asp Val Lys Gln Asn Gly Glu Gln
215 220 225GCC TTG AAT CTT TAT AAA AAG GGT TGT TAT TTA AAA AGG GGG AGC GGT 776Ala Leu Asn Leu Tyr Lys Lys Gly Cys Tyr Leu Lys Arg Gly Ser Gly
230 235 240TGT CAT AAT GTG GCG GTG ATG TAT TAC ACC GGT AAG GGC GTT CCA AAG 824Cys His Asn Val Ala Val Met Tyr Tyr Thr Gly Lys Gly Val Pro Lys
245 250 255GAT TTA GAT AAA GCC ATT TCG TAT TAT AAG AAA GGT TGC ACT CTA GGC 872Asp Leu Asp Lys Ala Ile Ser Tyr Tyr Lys Lys Gly Cys Thr Leu Gly
260 265 270TTT AGT GGT AGC TGT AAA GTG TTA GAA GAA GTG ATT GGC AAG AAG TCT 920Phe Ser Gly Ser Cys Lys Val Leu Glu Glu Val lle Gly Lys Lys Ser275 280 285 290GAT GAT TTG CAA GAT GAC GCG CAA AAC GAC ACG CAA GAT GAT ATG CAA T 969Asp Asp Leu Gln Asp Asp Ala Gln Asn Asp Thr Gln Asp Asp Met Gln
295 300 305AAGTTAAAGC TTATGGACTA ATGATTAAAA CTCATCTTAT AGAAATCTTT CT 1021
(2) Sequence 242 data:
(i) sequence characteristics:
(A) length: 306 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 242: met Ile Lys Ser Trp Thr Lys Lys Trp Phe Leu Ile Leu Phe Leu Met 151015 Ala Ser Cys Ser Ser Tyr Leu Val Ala Thr Thr Gly Glu Lys Tyr Phe
20 25 30Lys Met Ala Thr Gln Ala Phe Lys Arg Gly Asp Tyr His Lys Ala Val
35 40 45Ala Phe Tyr Lys Arg Ser Cys Asn Leu Arg Val Gly Val Gly Cys Thr
50 55 60Ser Leu Gly Ser Met Tyr Glu Asp Gly Asp Gly Val Asp Gln Asn Ile65 70 75 80Thr Lys Ala Val Phe Tyr Tyr Arg Arg Gly Cys Asn Leu Arg Asn His
85 90 95Leu Ala Cys Ala Ser Leu Gly Ser Met Tyr Glu Asp Gly Asp Gly Val
100 105 110Gln Lys Asn Leu Pro Lys Ala Ile Tyr Tyr Tyr Arg Arg Gly Cys His
115 120 125Leu Lys Gly Gly Val Ser Cys Gly Ser Leu Gly Phe Met Tyr Phe Asn
130 135 140Gly Thr Gly Val Lys Gln Asn Tyr Ala Lys Ala Leu Phe Leu Ser Lys145 150 155 160Tyr Ala Cys Ser Leu Asn Tyr Gly Ile Ser Cys Asn Phe Val Gly Tyr
165 170 175Met Tyr Arg Asn Ala Lys Gly Val Gln Lys Asp Leu Lys Lys Ala Leu
180 185 190Ala Asn Phe Lys Arg Gly Cys His Leu Lys Asp Gly Ala Ser Cys Val
195 200 205SerLeu Gly Tyr Met Tyr Glu Val Gly Met Asp Val Lys Gln Asn Gly
210 215 220Glu Gln Ala Leu Asn Leu Tyr Lys Lys Gly Cys Tyr Leu Lys Arg Gly225 230 235 240Ser Gly Cys His Asn Val Ala Val Met Tyr Tyr Thr Gly Lys Gly Val
245 250 255Pro Lys Asp Leu Asp Lys Ala Ile Ser Tyr Tyr Lys Lys Gly Cys Thr
260 265 270Leu Gly Phe Ser Gly Ser Cys Lys Val Leu Glu Glu Val Ile Gly Lys
275 280 285Lys Sar Asp Asp Leu Gln Asp Asp Ala Gln Asn Asp Thr Gln Asp Asp
290 295 300Met Gln305
(2) Sequence 243 data:
(i) sequence characteristics:
(A) length: 1000bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...947
(D) Other information:
(xi) Description of the sequence: sequence 243: CTATAATGTG AATTTAATGA TGAAAATTAG TTTAGAGTGG AGAACACACA ATG AAA 56
Met Lys
1AAA AAT ATC TTA AAT TTA GCG TTA GTG GGT GCG TTG AGC ACG TCG TTT 104Lys Asn Ile Leu Asn Leu Ala Leu Val Gly Ala Leu Ser Thr Ser Phe
5 10 15TTG ATG GCT AAG CCG GCT CAT AAC GCA AAT AAC GCT ACG CAT AAC ACG 152Leu Met Ala Lys Pro Ala His Asn Ala Asn Asn Ala Thr His Asn Thr
20 25 30AAA AAA ACG ACT GAT TCT TCA GCA GGC GTG TTA GCG ACA GTG GAT GGC 200Lys Lys Thr Thr Asp Ser Ser Ala Gly Val Leu Ala Thr Val Asp Gly35 40 45 50AGA CCT ATC ACT AAA AGC GAT TTT GAC ATG ATT AAG CAA CGA AAT CCT 248Arg Pro Ile Thr Lys Ser Asp Phe Asp Met Ile Lys Gln Arg Asn Pro
55 60 65AAT TTT GAT TTT GAC AAG CTT AAA GAG AAA GAA AAA GAA GCC TTG ATT 296Asn Phe Asp Phe Asp Lys Leu Lys Glu Lys Glu Lys Glu Ala Leu Ile
70 75 80GAT CAA GCT ATT CGC ACC GCC CTT GTA GAA AAT GAA GCT AAA ACC GAG 344Asp Gln Ala Ile Arg Thr Ala Leu Val Glu Asn Glu Ala Lys Thr Glu
85 90 95AAA TTG GAC AGC ACT CCA GAA TTT AAA GCG ATG ATG GAA GCG GTT AAA 392Lys Leu Asp Ser Thr Pro Glu Phe Lys Ala Met Met Glu Ala Val Lys
100 105 110AAA CAG GCT TTA GTG GAA TTT TGG GCT AAA AAA CAG GCT GAA GAA GTG 440Lys Gln Ala Leu Val Glu Phe Trp Ala Lys Lys Gln Ala Glu Glu Val115 120 125 130AAA AAA GTC CAA ATC CCA GAA AAA GAA ATG CAA GAT TTT TAC AAC GCT 488Lys Lys Val Gln Ile Pro Glu Lys Glu Met Gln Asp Phe Tyr Asn Ala
135 140 145AAC AAA GAT CAG CTT TTT GTC AAG CAA GAA GCC CAT GCT AGG CAT ATT 536Asn Lys Asp Gln Leu Phe Val Lys Gln Glu Ala His Ala Arg His Ile
150 155 160TTA GTG AAA ACC GAA GAT GAG GCT AAA CGG ATTATT TCT GAG ATT GAC 584Leu Val Lys Thr Glu Asp Glu Ala Lys Arg Ile Ile Ser Glu Ile Asp
165 170 175AAA CAG CCA AAG GCT AAA AAA GAA GCT AAA TTC ATT GAG TTA GCC AAT 632Lys Gln Pro Lys Ala Lys Lys Glu Ala Lys Phe Ile Glu Leu Ala Asn
180 185 190CGG GAT ACG ATT GAT CCT AAC AGC AAG AAC GCG CAA AAT GGC GGT GAT 680Arg Asp Thr Ile Asp Pro Asn Ser Lys Asn Ala Gln Asn Gly Gly Asp195 200 205 210TTG GGG AAA TTC CAA AAG AAC CAA ATG GCT CCG GAT TTT TCT AAA GCC 728Leu Gly Lys Phe Gln Lys Asn Gln Met Ala Pro Asp Phe Ser Lys Ala
215 220 225GCT TTC GCT TTA ACT CCT GGG GAT TAC ACT AAA ACC CCT GTT AAA ACA 776Ala Phe Ala Leu Thr Pro Gly Asp Tyr Thr Lys Thr Pro Val Lys Thr
230 235 240GAG TTT GGT TAT CAT ATT ATC TAT TTG ATT TCT AAA GAT AGC CCT GTA 824Glu Phe Gly Tyr His Ile Ile Tyr Leu Ile Ser Lys Asp Ser Pro Val
245 250 255ACT TAT ACT TAT GAA CAG GCT AAA CCT ACC ATT AAG GGG ATG TTA CAA 872Thr Tyr Thr Tyr Glu Gln Ala Lys Pro Thr Ile Lys Gly Met Leu Gln
260 265 270GAA AAG CTT TTC CAA GAA CGC ATG AAT CAA CGC ATT GAG GAA CTA AGA 920Glu Lys Leu Phe Gln Glu Arg Met Asn Gln Arg Ile Glu Glu Leu Arg275 280 285 290AAG CAC GCT AAA ATT GTT ATC AAC AAG TAATTGATGA GGTGTTATCA TGTTAGT 974Lys His Ala Lys Ile Val Ile Asn Lys
295TAAAGGCAAT GAAATTTTAT TGAAAG 1000
(2) Sequence 244 data:
(i) sequence characteristics:
(A) length: 299 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 244: met Lys Lys Asn Ile Leu Asn Leu Ala Leu Val Gly Ala Leu Ser Thr 151015 Ser Phe Leu Met Ala Lys Pro Ala His Asn Ala Asn Asn Ala Thr His
20 25 30Asn Thr Lys Lys Thr Thr Asp Ser Ser Ala Gly Val Leu Ala Thr Val
35 40 45Asp Gly Arg Pro Ile Thr Lys Ser Asp Phe Asp Met Ile Lys Gln Arg
50 55 60Asn Pro Asn Phe Asp Phe Asp Lys Leu Lys Glu Lys Glu Lys Glu Ala65 70 75 80Leu Ile Asp Gln Ala Ile Arg Thr Ala Leu Val Glu Asn Glu Ala Lys
85 90 95Thr Glu Lys Leu Asp Ser Thr Pro Glu Phe Lys Ala Met Met Glu Ala
100 105 110Val Lys Lys Gln Ala Leu Val Glu Phe Trp Ala Lys Lys Gln Ala Glu
115 120 125Glu Val Lys Lys Val Gln Ile Pro Glu Lys Glu Met Gln Asp Phe Tyr
130 135 140Asn Ala Asn Lys Asp Gln Leu Phe Val Lys Gln Glu Ala His Ala Arg145 150 155 160His Ile Leu Val Lys Thr Glu Asp Glu Ala Lys Arg Ile Ile Ser Glu
165 170 175Ile Asp Lys Gln Pro Lys Ala Lys Lys Glu Ala Lys Phe Ile Glu Leu
180 185 190Ala Asn Arg Asp Thr Ile Asp Pro Asn Ser Lys Asn Ala Gln Asn Gly
195 200 205Gly Asp Leu Gly Lys Phe Gln Lys Asn Gln Met Ala Pro Asp Phe Ser
210 215 220Lys Ala Ala Phe Ala Leu Thr Pro Gly Asp Tyr Thr Lys Thr Pro Val225 230 235 240Lys Thr Glu Phe Gly Tyr His Ile Ile Tyr Leu Ile Ser Lys Asp Ser
245 250 255Pro Val Thr Tyr Thr Tyr Glu Gln Ala Lys Pro Thr Ile Lys Gly Met
260 265 270Leu Gln Glu Lys Leu Phe Gln Glu Arg Met Asn Gln Arg Ile Glu Glu
275 280 285Leu Arg Lys His Ala Lys Ile Val Ile Asn Lys
290 295
(2) Sequence 245 data:
(i) sequence characteristics:
(A) length: 376bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...323
(D) Other information:
(xi) Description of the sequence: sequence 245: CAGCGTTGGT GTATTTTGGA GGAAGTTAGG AAAATATTGA AGGAGTATTG ATG AAA 56
Met Lys
1AAG GTT GTT TTT TTA TTG TTA GTT ATA CTA GGG GGT TTA GAA GCG CAA 104Lys Val Val Phe Leu Leu Leu Val Ile Leu Gly Gly Leu Glu Ala Gln
5 10 15AGT ACT TAT TGC AGT GAT CAT TGC GAA GGC ACG CCA GAT AGC CGT ATC 152Ser Thr Tyr Cys Ser Asp His Cys Glu Gly Thr Pro Asp Ser Arg Ile
20 25 30CCT CCT ATG GGG TTT CAT TTC AGT TTT GTG CAT TCA GTG AAA TAT TAC 200Pro Pro Met Gly Phe His Phe Ser Phe Val His Ser Val Lys Tyr Tyr35 40 45 50TTG CAA GAT CCG CAA GAG CGC GAT CAC AAG CTT GAA AAA TGC CAT CAA 248Leu Gln Asp Pro Gln Glu Arg Asp His Lys Leu Glu Lys Cys His Gln
55 60 65GCC TTT GAT TCG ACT CTT AAG GTT AAT TTT ATT ACG AAT CTT TTA AAA 296Ala Phe Asp Ser Thr Leu Lys Val Asn Phe lle Thr Asn Leu Leu Lys
70 75 80AGG ATT GCA AGC ATG CGC AAA TGG CTT TAGAGCAAGC CCAAAAAGGG ACTCCAT 350Arg Ile Ala Ser Met Arg Lys Trp Leu
85 90AAAAGGGGTT TCTTTAGGGA TTTTAT 376
(2) Sequence 246 data:
(i) sequence characteristics:
(A) length: 91 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 246: met Lys Lys Val Val Phe Leu Leu Leu Val Ile Leu Gly Gly Leu Glu151015 Ala Gln Ser Thr Tyr Cys Ser Asp His Cys Glu Gly Thr Pro Asp Ser
20 25 30Arg Ile Pro Pro Met Gly Phe His Phe Ser Phe Val His Ser Val Lys
35 40 45Tyr Tyr Leu Gln Asp Pro Gln Glu Arg Asp His Lys Leu Glu Lys Cys
50 55 60His Gln Ala Phe Asp Ser Thr Leu Lys Val Asn Phe Ile Thr Asn Leu65 70 75 80Leu Lys Arg Ile Ala Ser Met Arg Lys Trp Leu
85 90
(2) Sequence 247 data:
(i) sequence characteristics:
(A) length: 1180bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1127
(D) Other information:
(xi) Description of the sequence: sequence 247: TTTTTAGTTA TAATGGCGGA CACCATTAAA ATTAAAACAA AGGTTATTCA ATG AAG 56
Met Lys
1GTA TTA TCT TAT TTG AAA AAT TTT TAT CTT TTT TTA GCG ATA GGA GCA 104Val Leu Ser Tyr Leu Lys Asn Phe Tyr Leu Phe Leu Ala Ile Gly Ala
5 10 15ATT ATG CAA GCG AGT GAA AAC ATG GGA TCT CAA CAC CAA AAA ACC GAT 152Ile Met Gln Ala Ser Glu Asn Met Gly Ser Gln His GIn Lys Thr Asp
20 25 30GAA AGA GTG ATT TAC TTG GCT GGG GGG TGT TTT TGG GGG CTA GAG GCG 200Glu Arg Val Ile Tyr Leu Ala Gly Gly Cys Phe Trp Gly Leu Glu Ala35 40 45 50TAT ATG GAG AGG ATT TAT GGC GTC ATA GAC GCA AGC TCT GGT TAC GCT 248Tyr Met Glu Arg Ile Tyr Gly Val Ile Asp Ala Ser Ser Gly Tyr Ala
55 60 65AAC GGC AAG ACT TCA AGC ACG AAT TAT GAG AAA TTG CAT GAA AGT GAT 296Asn Gly Lys Thr Ser Ser Thr Asn Tyr Glu Lys Leu His Glu Ser Asp
70 75 80CAT GCT GAA AGC GTG AAA GTC ATT TAT GAT CCT AAA AAA ATC AGT TTG 344His Ala Glu Ser Val Lys Val Ile Tyr Asp Pro Lys Lys Ile Ser Leu
85 90 95GAC AAA TTG TTG CGT TAC TAT TTT AAG GTG GTT GAT CCG GTG AGC GTG 392Asp Lys Leu Leu Arg Tyr Tyr Phe Lys Val Val Asp Pro Val Ser Val
100 105 110AAC AAG CAG GGT AAT GAT GTG GGC AGG CAG TAT CGC ACG GGG ATT TAT 440Asn Lys Gln Gly Asn Asp Val Gly Arg Gln Tyr Arg Thr Gly Ile Tyr115 120 125 130TAT GTC AAT AGC GCG GAT AAA GAA GTG ATA GAT CAT GCC TTA AAA GCG 488Tyr Val Asn Ser Ala Asp Lys Glu Val Ile Asp His Ala Leu Lys Ala
135 140 145TTA CAG AAA GAA GTG AAA GGT AAA ATC GCT ATT GAA GTA GAG CCT TTA 536Leu Gln Lys Glu Val Lys Gly Lys Ile Ala Ile Glu Val Glu Pro Leu
150 155 160AAA AAT TAT GTG AGG GCT GAA GAG TAT CAT CAG GAT TAT TTG AAG AAA 584Lys Asn Tyr Val Arg Ala Glu Glu Tyr His Gln Asp Tyr Leu Lys Lys
165 170 175CAC CCT AGT GGT TAT TGC CAT ATT GAT TTG AAA AAG GCG GAT GAA GTG 632His Pro Ser Gly Tyr Cys His Ile Asp Leu Lys Lys Ala Asp Glu Val
180 185 190ATT GTG GAT GAC GAT AAA TAC ACC AAA CCT AGC GAT GAA GTT TTA AAG 680Ile Val Asp Asp Asp Lys Tyr Thr Lys Pro Ser Asp Glu Val Leu Lys195 200 205 210AAA AAA CTC ACC AAA CTC CAG TAT GAG GTT ACG CAA AAC AAA CAC ACT 728Lys Lys Leu Thr Lys Leu Gln Tyr Glu Val Thr Gln Asn Lys His Thr
215 220 225GAG AAA CCC TTT GAA AAC GAG TAT TAC AAC AAA GAA GAA GAG GGC ATT 776Glu Lys Pro Phe Glu Asn Glu Tyr Tyr Asn Lys Glu Glu Glu Gly Ile
230 235 240TAT GTG GAT ATT ACC ACA GGC GAG CCG TTA TTT TCT TCA GCG GAT AAA 824Tyr Val Asp Ile Thr Thr Gly Glu Pro Leu Phe Ser Ser Ala Asp Lys
245 250 255TAC GAC TCC GGT TGC GGG TGG CCA AGC TTT TCT AAG CCT ATC AAT AAA 872Tyr Asp Ser Gly Cys Gly Trp Pro Ser Phe Ser Lys Pro Ile Asn Lys
260 265 270GAT GTG GTG AAA TAC GAA GAC GAT GAG AGC CTT AAT AGG AAA CGC ATT 920Asp Val Val Lys Tyr Glu Asp Asp Glu Ser Leu Asn Arg Lys Arg Ile275 280 285 290GAA GTG TTG AGC CGT ATT GGT AAG GCG CAT TTA GGG CAT GTG TTT AAC 968Glu Val Leu Ser Arg Ile Gly Lys Ala His Leu Gly His Val Phe Asn
295 300 305GAT GGG CCT AAA GAA TTA GGG GGC TTA AGG TAT TGC ATC AAC AGC GCG 1016Asp Gly Pro Lys Glu Leu Gly Gly Leu Arg Tyr Cys Ile Asn Ser Ala
310 315 320GCT TTA AGG TTT ATC CCC TTA AAA GAC ATG GAA AAA GAG GGT TAT GGC 1064Ala Leu Arg Phe Ile Pro Leu Lys Asp Met Glu Lys Glu Gly Tyr Gly
325 330 335GAG TTT ATC CCT TAT ATC AAA AAG GGT GAA TTG AAA AAA TAC ATC AAT 1112Glu Phe Ile Pro Tyr Ile Lys Lys Gly Glu Leu Lys Lys Tyr Ile Asn
340 345 350GAT AAA AAG TCG CAT TAAGGGGTAA TGACTAAGCC CCCTAAGGGG GGTTAAAATG A 1168Asp Lys Lys Ser His355GGGGTTTAAG CG 1180
(2) Sequence 248 data:
(i) sequence characteristics:
(A) length: 359 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 248: met Lys Val Leu Ser Tyr Leu Lys Asn Phe Tyr Leu Phe Leu Ala Ile 151015 Gly Ala Ile Met Gln Ala Ser Glu Asn Met Gly Ser Gln His Gln Lys
20 25 30Thr Asp Glu Arg Val Ile Tyr Leu Ala Gly Gly Cys Phe Trp Gly Leu
35 40 45Glu Ala Tyr Met Glu Arg Ile Tyr Gly Val Ile Asp Ala Ser Ser Gly
50 55 60Tyr Ala Asn Gly Lys Thr Ser Ser Thr Asn Tyr Glu Lys Leu His Glu65 70 75 80Ser Asp His Ala Glu Ser Val Lys Val Ile Tyr Asp Pro Lys Lys Ile
85 90 95Ser Leu Asp Lys Leu Leu Arg Tyr Tyr Phe Lys Val Val Asp Pro Val
100 105 110Ser Val Asn Lys Gln Gly Asn Asp Val Gly Arg Gln Tyr Arg Thr Gly
115 120 125Ile Tyr Tyr Val Asn Ser Ala Asp Lys Glu Val Ile Asp His Ala Leu
130 135 140Lys Ala Leu Gln Lys Glu Val Lys Gly Lys Ile Ala Ile Glu Val Glu145 150 155 160Pro Leu Lys Asn Tyr Val Arg Ala Glu Glu Tyr His Gln Asp Tyr Leu
165 170 175Lys Lys His Pro Ser Gly Tyr Cys His Ile Asp Leu Lys Lys Ala Asp
180 185 190Glu Val Ile Val Asp Asp Asp Lys Tyr Thr Lys Pro Ser Asp Glu Val
195 200 205Leu Lys Lys Lys Leu Thr Lys Leu Gln Tyr Glu Val Thr Gln Asn Lys
210 215 220His Thr Glu Lys Pro Phe Glu Asn Glu Tyr Tyr Asn Lys Glu Glu Glu225 230 235 240Gly Ile Tyr Val Asp Ile Thr Thr Gly Glu Pro Leu Phe Ser Ser Ala
245 250 255Asp Lys Tyr Asp Ser Gly Cys Gly Trp Pro Ser Phe Ser Lys Pro Ile
260 265 270Asn Lys Asp Val Val Lys Tyr Glu Asp Asp Glu Ser Leu Asn Arg Lys
275 280 285Arg Ile Glu Val Leu Ser Arg Ile Gly Lys Ala His Leu Gly His Val
290 295 300Phe Asn Asp Gly Pro Lys Glu Leu Gly Gly Leu Arg Tyr Cys Ile Asn305 310 315 320Ser Ala Ala Leu Arg Phe Ile Pro Leu Lys Asp Met Glu Lys Glu Gly
325 330 335Tyr Gly Glu Phe Ile Pro Tyr Ile Lys Lys Gly Glu Leu Lys Lys Tyr
340 345 350Ile Asn Asp Lys Lys Ser His
355
(2) Sequence 249 data:
(i) sequence characteristics:
(A) length: 898bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...845
(D) Other information:
(xi) Description of the sequence: sequence 249: TTATTTCTTA TTATTGTAAG GATTTAGGCT ATTGAACTTT AGGAGTTTTA ATG ATA 56
Met Ile
1TTA AGA GCG AGT GTG TTG AGC GCG TTA CTT CTT GTA GGC TTA GGG GCA 104Leu Arg Ala Ser Val Leu Ser Ala Leu Leu Leu Val Gly Leu Gly Ala
5 10 15GCC CCT AAA CAT TCA GTT TCA GCT AAT GAC AAA CGG ATG CAG GAT AAT 152Ala Pro Lys His Ser Val Ser Ala Asn Asp Lys Arg Met Gln Asp Asn
20 25 30TTA GTG AGC GTG ATT GAA AAA CAG ACC AAT AAA AAG GTG CGT ATT TTA 200Leu Val Ser Val Ile Glu Lys Gln Thr Asn Lys Lys Val Arg Ile Leu35 40 45 50GAA ATC AAA CCT TTA AAA TCT AGC CAG GAT TTA AAA ATG GTC GTT ATT 248Glu Ile Lys Pro Leu Lys Ser Ser Gln Asp Leu Lys Met Val Val Ile
55 60 65GAA GAT CCG GAC ACT AAA TAC AAT ATC CCG CTT GTG GTG AGT AAG GAT 296Glu Asp Pro Asp Thr Lys Tyr Asn Ile Pro Leu Val Val Ser Lys Asp
70 75 80GGT AAT TTA ATC ATA GGG CTT AGC AAC ATA TTC TTT AGC AAT AAA AGC 344Gly Asn Leu Ile Ile Gly Leu Ser Asn Ile Phe Phe Ser Asn Lys Ser
85 90 95GAT GAT GTG CAA TTA GTT GCA GAA ACC AAT CAA AAA GTT CAA GCT CTT 392Asp Asp Val Gln Leu Val Ala Glu Thr Asn Gln Lys Val Gln Ala Leu
100 105 110AAC GCC ACC CAA CAA AAT AGC GCG AAA TTG AAC GCT ATT TTT AAT GAA 440Asn Ala Thr Gln Gln Asn Ser Ala Lys Leu Asn Ala Ile Phe Asn Glu115 120 125 130ATA CCG GCT GAT TAT GCG ATA GAG TTG CCC TCT ACT AAC GCT GCA AAT 488Ile Pro Ala Asp Tyr Ala Ile Glu Leu Pro Ser Thr Asn Ala Ala Asn
135 140 145AAG GAT AAA ATC CTT TAT ATT GTC TCT GAT CCC ATG TGC CCA CAT TGC 536Lys Asp Lys lle Leu Tyr Ile Val Ser Asp Pro Met Cys Pro His Cys
150 155 160CAA AAA GAG CTC ACT AAA CTT AGG GAT CAT TTA AAA GAA AAC ACC GTG 584Gln Lys Glu Leu Thr Lys Leu Arg Asp His Leu Lys Glu Asn Thr Val
165 170 175AGA ATG GTC GTG GTG GGG TGG CTT GGG GTC AAT TCA GCT AAA AAA GCG 632Arg Met Val Val Val Gly Trp Leu Gly Val Asn Ser Ala Lys Lys Ala
180 185 190GCT TTA ATC CAA GAA GAA ATG GCG AAA GCT AGG GCT AGG GGA GCG AGC 680Ala Leu Ile Gln Glu Glu Met Ala Lys Ala Arg Ala Arg Gly Ala Ser195 200 205 210GTG GAA GAT AAG ATC TCT ATT CTT GAA AAG ATT TAT TCC ACC CAATAC 728Val Glu Asp Lys Ile Ser Ile Leu Glu Lys lle Tyr Ser Thr Gln Tyr
215 220 225GAT ATT AAC GCT CAA AAA GAG CCT GAA GAT TTA CGC ACT AAA GTG GAA 776Asp Ile Asn Ala Gln Lys Glu Pro Glu Asp Leu Arg Thr Lys Val Glu
230 235 240AAT ACC ACT AAA AAG ATT TTT GAA TCT GGC GTG ATT AAG GGT GTG CCT 824Asn Thr Thr Lys Lys Ile Phe Glu Ser Gly Val Ile Lys Gly Val Pro
245 250 255TTC TTA TAC CAT TAT AAG GCA TGATATAAGG TTGCTCTCAT GAAAAAACCC TATA 879Phe Leu Tyr His Tyr Lys Ala
260 265GGAAGATTTC TGATTATGC 898
(2) Sequence 250 data:
(i) sequence characteristics:
(A) length: 265 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 250: met Ile Leu Arg Ala Ser Val Leu Ser Ala Leu Leu Leu Val Gly Leu 151015 Gly Ala Ala Pro Lys His Ser Val Ser Ala Asn Asp Lys Arg Met Gln
20 25 30Asp Asn Leu Val Ser Val Ile Glu Lys Gln Thr Asn Lys Lys Val Arg
35 40 45Ile Leu Glu Ile Lys Pro Leu Lys Ser Ser Gln Asp Leu Lys Met Val
50 55 60Val Ile Glu Asp Pro Asp Thr Lys Tyr Asn Ile Pro Leu Val Val Ser65 7075 80Lys Asp Gly Asn Leu Ile Ile Gly Leu Ser Asn Ile Phe Phe Ser Asn
85 90 95Lys Ser Asp Asp Val Gln Leu Val Ala Glu Thr Asn Gln Lys Val Gln
100 105 110Ala Leu Asn Ala Thr Gln Gln Asn Ser Ala Lys Leu Asn Ala Ile Phe
115 120 125Asn Glu Ile Pro Ala Asp Tyr Ala Ile Glu Leu Pro Ser Thr Asn Ala
130 135 140Ala Asn Lys Asp Lys Ile Leu Tyr Ile Val Ser Asp Pro Met Cys Pro145 150 155 160His Cys Gln Lys Glu Leu Thr Lys Leu Arg Asp His Leu Lys Glu Asn
165 170 175Thr Val Arg Met Val Val Val Gly Trp Leu Gly Val Asn Ser Ala Lys
180 185 190Lys Ala Ala Leu Ile Gln Glu Glu Met Ala Lys Ala Arg Ala Arg Gly
195 200 205Ala Ser Val Glu Asp Lys Ile Ser Ile Leu Glu Lys Ile Tyr Ser Thr
210 215 220Gln Tyr Asp Ile Asn Ala Gln Lys Glu Pro Glu Asp Leu Arg Thr Lys225 230 235 240Val Glu Asn Thr Thr Lys Lys Ile Phe Glu Ser Gly Val Ile Lys Gly
245 250 255Val Pro Phe Leu Tyr His Tyr Lys Ala
260 265
(2) Sequence 251 data:
(i) sequence characteristics:
(A) length: 760bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...707
(D) Other information:
(xi) Description of the sequence: sequence 251: TCTTTTAGAC GAAAACGCCA TGATTTTACA CTGGCAAAAA GAGGGCTTGC ATG CGT 56
Met Arg
1AAA ATC TTG TTA TTG GGT CTG ATT TTA CAA GCG CTC TTC AGC GAA GAA 104Lys Ile Leu Leu Leu Gly Leu Ile Leu Gln Ala Leu Phe Ser Glu Glu
5 10 15GCC GCG CAA GAA TTG TTG CAA TGC TCT GCG ATT TTT GAA TCT AAA AAA 152Ala Ala Gln Glu Leu Leu Gln Cys Ser Ala Ile Phe Glu Ser Lys Lys
20 25 30GCC GAA TTG AAA GAC GAT TTG CGC CGA TTG AGT GAA AAA GAG CAG TCT 200Ala Glu Leu Lys Asp Asp Leu Arg Arg Leu Ser Glu Lys Glu Gln Ser35 40 45 50TTA AGG ATC TTG CAA ACC GAA AAC GCC CGC CTT TTA GAT GAA AAA ACC 248Leu Arg Ile Leu Gln Thr Glu Asn Ala Arg Leu Leu Asp Glu Lys Thr
55 60 65GAT CTG TTG AAC CAA AAA GAA AAA GAA GTG GAA GAA AAA CTG AAA AAT 296Asp Leu Leu Asn Gln Lys Glu Lys Glu Val Glu Glu Lys Leu Lys Asn
70 75 80TTA GCC GCT AAA GAA GAA GCC TTT AAA ACC TTA CAA ACG GAA GAA AAA 344Leu Ala Ala Lys Glu Glu Ala Phe Lys Thr Leu Gln Thr Glu Glu Lys
85 90 95AAA CGC CTT AAA AAT TTG ATA GAA GAAAAC GAA GGC ATT TTA AGA GAA 392Lys Arg Leu Lys Asn Leu Ile Glu Glu Asn Glu Gly Ile Leu Arg Glu
100 105 110ATC AAG CAG GCT AAA GAC AGC AAG ATT GGC GAG ACT TAT TCT AAA ATG 440Ile Lys Gln Ala Lys Asp Ser Lys Ile Gly Glu Thr Tyr Ser Lys Met115 120 125 130AAA GAT TCT AAA TCG GCT CTG ATT TTA GAA AAT TTA CCC ACT CAA AAC 488Lys Asp Ser Lys Ser Ala Leu Ile Leu Glu Asn Leu Pro Thr Gln Asn
135 140 145GCA TTA GAA ATT TTA ATG GCG CTA AAA CCC CAA GAA CTC GGT AAA ATT 536Ala Leu Glu Ile Leu Met Ala Leu Lys Pro Gln Glu Leu Gly Lys Ile
150 155 160TTA GCC AAA ATG GAT CCT AAA AAA GCG GCG GCT TTG ACA GAG TTG TGG 584Leu Ala Lys Met Asp Pro Lys Lys Ala Ala Ala Leu Thr Glu Leu Trp
165 170 175CAA AAA CCC CCA AAA GAA AAT AAA GAA ATC CCA AAA ACC ACA GCA CCC 632Gln Lys Pro Pro Lys Glu Asn Lys Glu Ile Pro Lys Thr Thr Ala Pro
180 185 190ACG CCC CCT ATA GCA CCC ACG CCT TTA AAA GAG CCG ATG ATA AAA GAT 680Thr Pro Pro Ile Ala Pro Thr Pro Leu Lys Glu Pro Met Ile Lys Asp195 200 205 210CCT AAC ACC AAA GAG CCT GCA GGG GTA TGATGTTCAT TGTAGCGGTT TTGATGC 734Pro Asn Thr Lys Glu Pro Ala Gly Val
215TGGCGTTTTT AATCTTTGTC CATGAA 760
(2) Sequence 252 data:
(i) sequence characteristics:
(A) length: 219 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 252: met Arg Lys Ile Leu Leu Leu Gly Leu Ile Leu Gln Ala Leu Phe Ser 151015 Glu Glu Ala Ala Gln Glu Leu Leu Gln Cys Ser Ala Ile Phe Glu Ser
20 25 30Lys Lys Ala Glu Leu Lys Asp Asp Leu Arg Arg Leu Ser Glu Lys Glu
35 40 45Gln Ser Leu Arg Ile Leu Gln Thr Glu Asn Ala Arg Leu Leu Asp Glu
50 55 60Lys Thr Asp Leu Leu Asn Gln Lys Glu Lys Glu Val Glu Glu Lys Leu65 70 75 80Lys Asn Leu Ala Ala Lys Glu Glu Ala Phe Lys Thr Leu Gln Thr Glu
85 90 95Glu Lys Lys Arg Leu Lys Asn Leu Ile Glu Glu Asn Glu Gly Ile Leu
100 105 110Arg Glu Ile Lys Gln Ala Lys Asp Ser Lys Ile Gly Glu Thr Tyr Ser
115 120 125Lys Met Lys Asp Ser Lys Ser Ala Leu Ile Leu Glu Asn Leu Pro Thr
130 135 140Gln Asn Ala Leu Glu Ile Leu Met Ala Leu Lys Pro Gln Glu Leu Gly145 150 155 160Lys Ile Leu Ala Lys Met Asp Pro Lys Lys Ala Ala Ala Leu Thr Glu
165 170 175Leu Trp Gln Lys Pro Pro Lys Glu Asn Lys Glu Ile Pro Lys Thr Thr
180 185 190Ala Pro Thr Pro Pro Ile Ala Pro Thr Pro Leu Lys Glu Pro Met Ile
195 200205Lys Asp Pro Asn Thr Lys Glu Pro Ala Gly Val
210 215
(2) Sequence 253 data:
(i) sequence characteristics:
(A) length: 1393bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1340
(D) Other information:
(xi) Description of the sequence: sequence 253: CTAAAGTGCG CTAAAATTCA CTTCAGTGAT ACAAAAAAGG AAATAAAATA ATG AAT 56
Met Asn
1ATT CAA ATA AAG AAA AGG TTT TTA GCA AAT TTG TTG CTT TTT AGC CTG 104Ile Gln Ile Lys Lys Arg Phe Leu Ala Asn Leu Leu Leu Phe Ser Leu
5 10 15TTT TGC CTT AAG GCT GAA ACC CTT TCA GAA GAT CAT CAA ATC CTG TTG 152Phe Cys Leu Lys Ala Glu Thr Leu Ser Glu Asp His Gln Ile Leu Leu
20 25 30AGT TCA GAC GCT TTC CAT AGA GGG GAT TTT GCT GCC GCT CAA AAA GGC 200Ser Ser Asp Ala Phe His Arg Gly Asp Phe Ala Ala Ala Gln Lys Gly35 40 45 50TAT ATG AAT CTC TAT AAG CAA ACC AAT AAG GTG GTG TAT GCT AAA GAA 248Tyr Met Asn Leu Tyr Lys Gln Thr Asn Lys Val Val Tyr Ala Lys Glu
55 60 65GCG GCC ATT TCA GCG GCG AGC TTA GGG GAT ATT AAA ACC GCT ATG CAT 296Ala Ala Ile Ser Ala Ala Ser Leu Gly Asp Ile Lys Thr Ala Met His
70 75 80TTA GCC ATG CTC TAT CAA AAA ATC ACC AAT AAT CGT AAT GAT GTT TCT 344Leu Ala Met Leu Tyr Gln Lys Ile Thr Asn Asn Arg Asn Asp Val Ser
85 90 95ATC AAT AAG ATT TTA GTG GAT GGC TAT GCG CAA ATG GGG CAG ATT GAT 392Ile Asn Lys Ile Leu Val Asp Gly Tyr Ala Gln Met Gly Gln Ile Asp
100 105 110AAG GCG ATT GAA TTG CTG CAC AAA ATC CGT AAA GAA GAA AAG ACC ATA 440Lys Ala Ile Glu Leu Leu His Lys Ile Arg Lys Glu Glu Lys Thr Ile115 120 125 130GCC ACA GAC AAT GTG TTA GGG ACT TTG TAT TTG ACT CAA AAG CGT TTG 488Ala Thr Asp Asn Val Leu Gly Thr Leu Tyr Leu Thr Gln Lys Arg Leu
135 140 145GAT AAG GCT TTC CCA TTG TTG AAT AAG TTT TAT AAC CAA GTG CAT GAT 536Asp Lys Ala Phe Pro Leu Leu Asn Lys Phe Tyr Asn Gln Val His Asp
150 155 160GAA GAC AGC CTA GAA AAA CTC ATT ACG ATC TAT TTT TTG CAA AAT CGT 584Glu Asp Ser Leu Glu Lys Leu Ile Thr Ile Tyr Phe Leu Gln Asn Arg
165 170 175AAA AAA GAG GGC TTG GAT TTG TTG CAA TCT CAT ATA GAC AGG TAT GGT 632Lys Lys Glu Gly Leu Asp Leu Leu Gln Ser His Ile Asp Arg Tyr Gly
180 185 190TGC TCA GAG CAA TTG TGC CAA AAA GCG CTC AAC ACT TTC ACG CAA TTT 680Cys Ser Glu Gln Leu Cys Gln Lys Ala Leu Asn Thr Phe Thr Gln Phe195 200 205 210AAC GAG CTT GAT TTG GCT AAA ACG ACT TTT GCT CGT TTG TAT GAA AAA 728Asn Glu Leu Asp Leu Ala Lys Thr Thr Phe Ala Arg Leu Tyr Glu Lys
215 220 225AAC CCT ATT GTT CAA AAT GCT CAG TTT TAC ATA GGG GTA TTA ATC TTG 776Asn Pro Ile Val Gln Asn Ala Gln Phe Tyr Ile Gly Val Leu Ile Leu
230 235 240TTA AAA GAG TTT GAT AAG GCC CAG AAA ATC GCA GAA TTA TTC CCT TTT 824Leu Lys Glu Phe Asp Lys Ala Gln Lys Ile Ala Glu Leu Phe Pro Phe
245 250 255GAC AGG CGT TTG TTG TTA GAC TTA TAC ACC GCA CAA AAA AAA TTC GAT 872Asp Arg Arg Leu Leu Leu Asp Leu Tyr Thr Ala Gln Lys Lys Phe Asp
260 265 270CAA GCT TCC AAA CAA GCT TCT TTG ATC TAT CAA GAA AAA AAA GAC CCT 920Gln Ala Ser Lys Gln Ala Ser Leu Ile Tyr Gln Glu Lys Lys Asp Pro275 280 285 290AAA TTC TTA GGA TTA GAG GCC ATT TAT CAT TAT GAA AGC TTG AGT GCG 968Lys Phe Leu Gly Leu Glu Ala Ile Tyr His Tyr Glu Ser Leu Ser Ala
295 300 305AAT AAG AAA AAG CTC ACC AAA GAA GAG ATG TTG CCT ATC ATT CAA AAA 1016Asn Lys Lys Lys Leu Thr Lys Glu Glu Met Leu Pro Ile Ile Gln Lys
310 315 320TTA GAG CAA GCC ACC AAA GAG CGC CAA GCA TGG CTC GCT AAA ACC AAA 1064Leu Glu Gln Ala Thr Lys Glu Arg Gln Ala Trp Leu Ala Lys Thr Lys
325 330 335GAT AAA GAA GAC GCG CAA GAC GCT TTC TTT TAT AAT TTT TTA GGG TAT 1112Asp Lys Glu Asp Ala Gln Asp Ala Phe Phe Tyr Asn Phe Leu Gly Tyr
340 345 350TCC TTA ATA GAT TAT GAC ATG GAT ATT AAA AGG GGC ATG GAT TTT GTG 1160Ser Leu Ile Asp Tyr Asp Met Asp Ile Lys Arg Gly Met Asp Phe Val355 360 365 370AGG AAA GCC TTA GCG TTG GAT TCT GGA TCA GTG CTT TAT TTG GAT TCT 1208Arg Lys Ala Leu Ala Leu Asp Ser Gly Ser Val Leu Tyr Leu Asp Ser
375 380 385TTA GCA TGG GGT TAT TAC AAA TTA GGG AAT TGT TTG GAA GCT AAA AAA 1256Leu Ala Trp Gly Tyr Tyr Lys Leu Gly Asn Cys Leu Glu Ala Lys Lys
390 395 400ATC TTT TCT AGC ATC GCT AAA GAG TCT ATC CAA GCC GAA CCT GAA TTG 1304Ile Phe Ser Ser Ile Ala Lys Glu Ser Ile Gln Ala Glu Pro Glu Leu
405 410 415AAA GAA CAC AAT AAA ATC ATT CAA GAA TGC AAG AAA TAGGGATTTT AGAAAA 1356Lys Glu His Asn Lys Ile Ile Gln Glu Cys Lys Lys
420 425 430TTTACAAAAA AGCTTAGCCT TAAAAGAGGG CATGCTT 1393
(2) Sequence 254 data:
(i) sequence characteristics:
(A) length: 430 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 254: met Asn Ile Gln Ile Lys Lys Arg Phe Leu Ala Asn Leu Leu Leu Phe 151015 Ser Leu Phe Cys Leu Lys Ala Glu Thr Leu Ser Glu Asp His Gln Ile
20 25 30Leu Leu Ser Ser Asp Ala Phe His Arg Gly Asp Phe Ala Ala Ala Gln
35 40 45Lys Gly Tyr Met Asn Leu Tyr Lys Gln Thr Asn Lys Val Val Tyr Ala
50 55 60Lys Glu Ala Ala Ile Ser Ala Ala Ser Leu Gly Asp Ile Lys Thr Ala65 70 75 80Met His Leu Ala Met Leu Tyr Gln Lys Ile Thr Asn Asn Arg Asn Asp
85 90 95Val Ser Ile Asn Lys Ile Leu Val Asp Gly Tyr Ala Gln Met Gly Gln
100 105 110Ile Asp Lys Ala Ile Glu Leu Leu His Lys Ile Arg Lys Glu Glu Lys
115 120 125Thr Ile Ala Thr Asp Asn Val Leu Gly Thr Leu Tyr Leu Thr Gln Lys
130 135 140Arg Leu Asp Lys Ala Phe Pro Leu Leu Asn Lys Phe Tyr Asn Gln Val145 150 155 160His Asp Glu Asp Ser Leu Glu Lys Leu Ile Thr Ile Tyr Phe Leu Gln
165 170 175Asn Arg Lys Lys Glu Gly Leu Asp Leu Leu Gln Ser His Ile Asp Arg
180 185 190Tyr Gly Cys Ser Glu Gln Leu Cys Gln Lys Ala Leu Asn Thr Phe Thr
195 200 205Gln Phe Asn Glu Leu Asp Leu Ala Lys Thr Thr Phe Ala Arg Leu Tyr
210 215 220Glu Lys Asn Pro Ile Val Gln Asn Ala Gln Phe Tyr Ile Gly Val Leu225 230 235 240Ile Leu Leu Lys Glu Phe Asp Lys Ala Gln Lys Ile Ala Glu Leu Phe
245 250 255Pro Phe Asp Arg Arg Leu Leu Leu Asp Leu Tyr Thr Ala Gln Lys Lys
260 265 270Phe Asp Gln Ala Ser Lys Gln Ala Ser Leu Ile Tyr Gln Glu Lys Lys
275 280 285Asp Pro Lys Phe Leu Gly Leu Glu Ala IleTyr His Tyr Glu Ser Leu
290 295 300Ser Ala Asn Lys Lys Lys Leu Thr Lys Glu Glu Met Leu Pro Ile Ile305 310 315 320Gln Lys Leu Glu Gln Ala Thr Lys Glu Arg Gln Ala Trp Leu Ala Lys
325 330 335Thr Lys Asp Lys Glu Asp Ala Gln Asp Ala Phe Phe Tyr Asn Phe Leu
340 345 350Gly Tyr Ser Leu Ile Asp Tyr Asp Met Asp Ile Lys Arg Gly Met Asp
355 360 365Phe Val Arg Lys Ala Leu Ala Leu Asp Ser Gly Ser Val Leu Tyr Leu
370 375 380Asp Ser Leu Ala Trp Gly Tyr Tyr Lys Leu Gly Asn Cys Leu Glu Ala385 390 395 400Lys Lys Ile Phe Ser Ser Ile Ala Lys Glu Ser Ile Gln Ala Glu Pro
405 410 415Glu Leu Lys Glu His Asn Lys Ile Ile Gln Glu Cys Lys Lys
420 425 430
(2) Sequence 255 data:
(i) sequence characteristics:
(A) length: 1090bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1037
(D) Other information:
(xi) Description of the sequence: sequence 255: TTACCCTAAA ACGCTATTTT TAAAATAATC CATTAAAATA AAGGCGAGGA ATG AAA 56
Met Lys
1AGA TTT GTT TTG TTT TTA TTG TTC ATG TGC GTT TGC GTT CAA GCT TAC 104Arg Phe Val Leu Phe Leu Leu Phe Met Cys Val Cys Val Gln Ala Tyr
5 10 15GCC GAG CAA GAT TAC TTT TTT AGG GAT TTT AAA TCT AGA GAT TTG CCC 152Ala Glu Gln Asp Tyr Phe Phe Arg Asp Phe Lys Ser Arg Asp Leu Pro
20 25 30CAA AAA CTC CAT CTT GAT AAA AAG CTC TCC CAA ACA ATA CAG CCA TGC 200Gln Lys Leu His Leu Asp Lys Lys Leu Ser Gln Thr Ile Gln Pro Cys35 40 45 50ATG CAA CTT AAC GCA TCA AAA CAC TAC ACT TCT ACC GGG GTT AGA GAG 248Met Gln Leu Asn Ala Ser Lys His Tyr Thr Ser Thr Gly Val Arg Glu
55 60 65CCT GAT AAA TGC ACA AAG AGT TTT AAA AAA TCC GCT CTC ATG TCC TAT 296Pro Asp Lys Cys Thr Lys Ser Phe Lys Lys Ser Ala Leu Met Ser Tyr
70 75 80GAC TTA GCG CTA GGT TAT TTG GTG AGT AAG AAT AAG CAA TAC GGC TTA 344Asp Leu Ala Leu Gly Tyr Leu Val Ser Lys Asn Lys Gln Tyr Gly Leu
85 90 95AAG GCT ATA GAA ATT TTA AAC GCT TGG GCT AAA GAG CTT CAA AGC GTG 392Lys Ala Ile Glu Ile Leu Asn Ala Trp Ala Lys Glu Leu Gln Ser Val
100 105 110GAT ACT TAT CAG AGC GAG GAT AAT ATC AAT TTT TAC ATG CCT TAT ATG 440Asp Thr Tyr Gln Ser Glu Asp Asn Ile Asn Phe Tyr Met Pro Tyr Met115 120 125 130AAC ATG GCT TAT TGG TTT GTC AAA AAG GCG TTT CCT AGC CCA GAA TAT 488Asn Met Ala TyrTrp Phe Val Lys Lys Ala Phe Pro Ser Pro Glu Tyr
135 140 145GAA GAT TTC ATT AAG CGG ATG CGC CAG TAT TCT CAA TCA GCT CTT AAC 536Glu Asp Phe Ile Lys Arg Met Arg Gln Tyr Ser Gln Ser Ala Leu Asn
150 155 160ACT AAC CAT GGG GCG TGG GGC ATT CTT TTT GAT GTG AGT TCT GCG CTA 584Thr Asn His Gly Ala Trp Gly Ile Leu Phe Asp Val Ser Ser Ala Leu
165 170 175GCG TTA GAC GAT AAT GCC CTT TTG CAC AAT AGC GCT AAT CGG TGG CAG 632Ala Leu Asp Asp Asn Ala Leu Leu His Asn Ser Ala Asn Arg Trp Gln
180 185 190GAG TGG GTG TTT AAA GCC ATA GAT GAG AAT GGG GTT ATT GNT AGC GCG 680Glu Trp Val Phe Lys Ala lle Asp Glu Asn Gly Val Ile Xaa Ser Ala195 200 205 210ATC ACT AGG AGC GAT ACG AGC GAT TAT CAT GGC GGC CCT ACA AAG GGC 728Ile Thr Arg Ser Asp Thr Ser Asp Tyr His Gly Gly Pro Thr Lys Gly
215 220 225ATT AAG GGG ATA GCT TAT ACC AAT TTC GCG CTT CTT GCG CTA ACC ATA 776Ile Lys Gly Ile Ala Tyr Thr Asn Phe Ala Leu Leu Ala Leu Thr Ile
230 235 240TCA GGC GAA TTG CTT TTT GAG AAC GGG TAT GAT TTG TGG GGT AGT GGA 824Ser Gly Glu Leu Leu Phe Glu Asn Gly Tyr Asp Leu Trp Gly Ser Gly
245 250 255GCT GGG AAA AGG CTC TCT GTG GCG TAT AAC AAA GTT GCA ACA TGG ATT 872Ala Gly Lys Arg Leu Ser Val Ala Tyr Asn Lys Val Ala Thr Trp Ile
260 265 270TTA AAC CCT GAA ACT TTC CCT TAT TTC CAG CCT AAC CTT ATC GGG GTG 920Leu Asn Pro Glu Thr Phe Pro Tyr Phe Gln Pro Asn Leu Ile Gly Val275 280285 290CAT AAC AAC GCC TAT TTC ATT ATT TTA GCC AAG CAT TAT TCT AGC CCT 968His Asn Asn Ala Tyr Phe Ile Ile Leu Ala Lys His Tyr Ser Ser Pro
295 300 305AGT GCA AAT GAG CTT TTA AAG CAA GGC GAT TTA CAC GAA GAT GGT TTC 1016Ser Ala Asn Glu Leu Leu Lys Gln Gly Asp Leu His Glu Asp Gly Phe
310 315 320AGG CTG AAA CTC CGA TCG CCA TGAATTTTTC TGTATCCAAG GTTAGCCTTA AGGA 1071Arg Leu Lys Leu Arg Ser Pro
325TGGCCATGCG CTTTAACCT 1090
(2) Sequence 256 data:
(i) sequence characteristics:
(A) length: 329 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 256: met Lys Arg Phe Val Leu Phe Leu Leu Phe Met Cys Val Cys Val Gln 151015 Ala Tyr Ala Glu Gln Asp Tyr Phe Phe Arg Asp Phe Lys Ser Arg Asp
20 25 30Leu Pro Gln Lys Leu His Leu Asp Lys Lys Leu Ser Gln Thr Ile Gln
35 40 45Pro Cys Met Gln Leu Asn Ala Ser Lys His Tyr Thr Ser Thr Gly Val
50 55 60Arg Glu Pro Asp Lys Cys Thr Lys Ser Phe Lys Lys Ser Ala Leu Met65 70 75 80Ser Tyr Asp Leu Ala Leu Gly Tyr Leu Val Ser Lys Asn Lys Gln Tyr
8590 95Gly Leu Lys Ala Ile Glu Ile Leu Asn Ala Trp Ala Lys Glu Leu Gln
100 105 110Ser Val Asp Thr Tyr Gln Ser Glu Asp Asn Ile Asn Phe Tyr Met Pro
115 120 125Tyr Met Asn Met Ala Tyr Trp Phe Val Lys Lys Ala Phe Pro Ser Pro
130 135 140Glu Tyr Glu Asp Phe Ile Lys Arg Met Arg Gln Tyr Ser Gln Ser Ala145 150 155 160Leu Asn Thr Asn His Gly Ala Trp Gly Ile Leu Phe Asp Val Ser Ser
165 170 175Ala Leu Ala Leu Asp Asp Asn Ala Leu Leu His Asn Ser Ala Asn Arg
180 185 190Trp Gln Glu Trp Val Phe Lys Ala Ile Asp Glu Asn Gly Val Ile Xaa
195 200 205Ser Ala Ile Thr Arg Ser Asp Thr Ser Asp Tyr His Gly Gly Pro Thr
210 215 220Lys Gly Ile Lys Gly Ile Ala Tyr Thr Asn Phe Ala Leu Leu Ala Leu225 230 235 240Thr Ile Ser Gly Glu Leu Leu Phe Glu Asn Gly Tyr Asp Leu Trp Gly
245 250 255Ser Gly Ala Gly Lys Arg Leu Ser Val Ala Tyr Asn Lys Val Ala Thr
260 265 270Trp Ile Leu Asn Pro Glu Thr Phe Pro Tyr Phe Gln Pro Asn Leu Ile
275 280 285Gly Val His Asn Asn Ala Tyr Phe Ile Ile Leu Ala Lys His Tyr Ser
290 295 300Ser Pro Ser Ala Asn Glu Leu Leu Lys Gln Gly Asp Leu His Glu Asp305 310 315 320Gly Phe ArgLeu Lys Leu Arg Ser Pro
325
(2) Sequence 257 data:
(i) sequence characteristics:
(A) length: 373bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...320
(D) Other information:
(xi) Description of the sequence: sequence 257: TTAACGATCG CAAAAGCCGA TGAAAGTTTT GATGAAATCA TAAAAGGTGT GTG AAT 56
Val Asn
1TTT TTG AAA AAG CCA AAG TAT TAT AAA TTC ATA GAG GGG GCG AAT TAT 104Phe Leu Lys Lys Pro Lys Tyr Tyr Lys Phe Ile Glu Gly Ala Asn Tyr
5 10 15TTG AGC TTG GGG CTT TCT ATG GTG GTA GCG ATC CTT ATG GGC GTG GCT 152Leu Ser Leu Gly Leu Ser Met Val Val Ala Ile Leu Met Gly Val Ala
20 25 30ATA GGC TAT GGG CTT AAA AAA CTC ACT CAT ATT TCG TGG CTT TTT TGG 200Ile Gly Tyr Gly Leu Lys Lys Leu Thr His Ile Ser Trp Leu Phe Trp35 40 45 50CTT GGG GTT ATT TGG GGC GTC TTA GCG AGC TTT CTC AAT GTC TAT AAA 248Leu Gly Val Ile Trp Gly Val Leu Ala Ser Phe Leu Asn Val Tyr Lys
55 60 65GCT TAT AAA AAC ATG CAA AAA GAC TAT GAA GAA CTA GCC AAA GAC CCT 296Ala Tyr Lys Asn Met Gln Lys Asp Tyr Glu Glu Leu Ala Lys Asp Pro
70 75 80AAA TAC ACA CAA AAT AAA ACA AAA TAAATCCAAT CAAATCCCAT GTGCCAAATC 350Lys Tyr Thr Gln Asn Lys Thr Lys
85 90CAATGCTTGC TTATTTTACT TTC 373
(2) Sequence 258 data:
(i) sequence characteristics:
(A) length: 90 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 258: val Asn Phe Leu Lys Lys Pro Lys Tyr Tyr Lys Phe Ile Glu Gly Ala 151015 Asn Tyr Leu Ser Leu Gly Leu Ser Met Val Val Ala Ile Leu Met Gly
20 25 30Val Ala Ile Gly Tyr Gly Leu Lys Lys Leu Thr His Ile Ser Trp Leu
35 40 45Phe Trp Leu Gly Val Ile Trp Gly Val Leu Ala Ser Phe Leu Asn Val
50 55 60Tyr Lys Ala Tyr Lys Asn Met Gln Lys Asp Tyr Glu Glu Leu Ala Lys65 70 75 80Asp Pro Lys Tyr Thr Gln Asn Lys Thr Lys
85 90
(2) Sequence 259 data:
(i) sequence characteristics:
(A) length: 643bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...590
(D) Other information:
(xi) Description of the sequence: a sequence 259: TTGGTTGGTT GTTTTTATCA TAGAGTGTAA TTTAAAATAA GGATCATTTG ATG TTA 56
Met Leu
1AAC AAG TTT AAA AAA ATC GTT GGC GTT AGT GTG TTA GTG GGC TGT TTA 104Asn Lys Phe Lys Lys Ile Val Gly Val Ser Val Leu Val Gly Cys Leu
5 10 15GGG GTT TTG CAA GCT AAA AAC AGC TTA TTT GTC TTA CCT TAT GAG CAA 152Gly Val Leu Gln Ala Lys Asn Ser Leu Phe Val Leu Pro Tyr Glu Gln
20 25 30AAA GAC GCT CTC AAT TCT TTA GTT TCT GGC ATT AGT AAC GCC AGA GAG 200Lys Asp Ala Leu Asn Ser Leu Val Ser Gly Ile Ser Asn Ala Arg Glu35 40 45 50AGC GTG AAA ATC GCT ATC TAT AGT TTC ACG CAC AGA GAT ATT GCA AGA 248Ser Val Lys Ile Ala Ile Tyr Ser Phe Thr His Arg Asp Ile Ala Arg
55 60 65GCG ATT AAA AGC GTA GCG AGT AGG GGG ATT AAG GTG CAA ATC ATT TAT 296Ala Ile Lys Ser Val Ala Ser Arg Gly Ile Lys Val Gln Ile Ile Tyr
70 75 80GAT TAT GAA AGC AAT CAT CAT AAC AAG CAA TCC ACT ATT GGC TAT CTG 344Asp Tyr Glu Ser Asn His His Asn Lys Gln Ser Thr Ile Gly Tyr Leu
85 90 95GAC AAA TAC CCT AAC ACG AAA GTG TGC TTA TTG AAA GGG CTT AAG GCT 392Asp Lys Tyr Pro Asn Thr Lys Val Cys Leu Leu Lys Gly Leu Lys Ala
100 105 110AAA AAC GGG AAT TAT TAC GGC ATC ATG CAC CAA AAA GTA GCG ATC ATT 440Lys Asn Gly Asn Tyr Tyr Gly Ile Met His Gln Lys Val Ala Ile Ile115 120 125 130GAT GAT AAG ATC GTG TTT TTA GGC TCA GCG AAT TGG AGC AAA AAC GCT 488Asp Asp Lys Ile Val Phe Leu Gly Ser Ala Asn Trp Ser Lys Asn Ala
135 140 145TTT GAA AAC AAT TAT GAA GTG CTT TTA AAA ACC GAT GAC ACA GAA ACG 536Phe Glu Asn Asn Tyr Glu Val Leu Leu Lys Thr Asp Asp Thr Glu Thr
150 155 160ATC CTC AAA GCC AAG AGC TAT TAC CAA AAG ATG TTA GGG AGT TGC GTT 584Ile Leu Lys Ala Lys Ser Tyr Tyr Gln Lys Met Leu Gly Ser Cys Val
165 170 175GGG TTT TAAAAGCCCT TTAGAAGTGG TAATTATACC CCACATAAAA GGCAAAGACC CT 642Gly Phe
180A 643
(2) Sequence 260 data:
(i) sequence characteristics:
(A) length: 180 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 260: met Leu Asn Lys Phe Lys Lys Ile Val Gly Val Ser Val Leu Val Gly 151015 Cys Leu Gly Val Leu Gln Ala Lys Asn Ser Leu Phe Val Leu Pro Tyr
2025 30Glu Gln Lys Asp Ala Leu Asn Ser Leu Val Ser Gly Ile Ser Asn Ala
35 40 45Arg Glu Ser Val Lys Ile Ala Ile Tyr Ser Phe Thr His Arg Asp Ile
50 55 60Ala Arg Ala Ile Lys Ser Val Ala Ser Arg Gly Ile Lys Val Gln Ile65 70 75 80Ile Tyr Asp Tyr Glu Ser Asn His His Asn Lys Gln Ser Thr Ile Gly
85 90 95Tyr Leu Asp Lys Tyr Pro Asn Thr Lys Val Cys Leu Leu Lys Gly Leu
100 105 110Lys Ala Lys Asn Gly Asn Tyr Tyr Gly Ile Met His Gln Lys Val Ala
115 120 125Ile Ile Asp Asp Lys Ile Val Phe Leu Gly Ser Ala Asn Trp Ser Lys
130 135 140Asn Ala Phe Glu Asn Asn Tyr Glu Val Leu Leu Lys Thr Asp Asp Thr145 150 155 160Glu Thr Ile Leu Lys Ala Lys Ser Tyr Tyr Gln Lys Met Leu Gly Ser
165 170 175Cys Val Gly Phe
180
(2) Data of sequence 261:
(i) sequence characteristics:
(A) length: 814bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...761
(D) Other information:
(xi) Description of the sequence: a sequence 261: TATAAGAGAG TATAATTCAA GGCTTAAAAT AACTCAAGTA AGGCTAGTGG ATG AAA 56
Met Lys
1AAA GCG CTT TAT TTA GGG GCT GTT GCG TTT AGC GTT GCA TTC AGC ATG 104Lys Ala Leu Tyr Leu Gly Ala Val Ala Phe Ser Val Ala Phe Ser Met
5 10 15GCA TCA GCC AAT GAG CCA AAA ATT GAT TTT AAC CCT CCC AAT TAT GTA 152Ala Ser Ala Asn Glu Pro Lys Ile Asp Phe Asn Pro Pro Asn Tyr Val
20 25 30GAA GAA ACC CCC TCT AAA GAA TTT ATC CCT GAA TTG AAC AAG TTA GGG 200Glu Glu Thr Pro Ser Lys Glu Phe Ile Pro Glu Leu Asn Lys Leu Gly35 40 45 50AGT TTG TTT GGG CAG GGT GAG CGC CCC TTG TTT GCG GAC AGG AGG GCG 248Ser Leu Phe Gly Gln Gly Glu Arg Pro Leu Phe Ala Asp Arg Arg Ala
55 60 65ATG AAG CCT AAC GAT TTG ATC ACA ATC ATT GTT TCT GAA AAA GCG AGC 296Met Lys Pro Asn Asp Leu Ile Thr Ile Ile Val Ser Glu Lys Ala Ser
70 75 80GCG AAT TAT TCC AGC TCT AAA GAT TAT AAA AGC GCT TCA GGG GGT AAT 344Ala Asn Tyr Ser Ser Ser Lys Asp Tyr Lys Ser Ala Ser Gly Gly Asn
85 90 95TCC ACG CCC CCA AGA CTC ACT TAT AAC GGG CTA GAT GAA AGA AAG AAA 392Ser Thr Pro Pro Arg Leu Thr Tyr Asn Gly Leu Asp Glu Arg Lys Lys
100 105 110AAA GAA GCG GAG TAT TTA GAC GAT AAG AAT AAT TAC AAT TTC ACC AAA 440Lys Glu Ala Glu Tyr Leu Asp Asp Lys Asn Asn Tyr Asn Phe Thr Lys115120 125 130TCC AGC AAT AAC ACG AAT TTT AAA GGC GGT GGC TCG CAA AAA AAG AGC 488Ser Ser Asn Asn Thr Asn Phe Lys Gly Gly Gly Ser Gln Lys Lys Ser
135 140 145GAA GAT TTA GAG ATT GTG TTG AGC GCT CGA ATC ATT AAG GTG CTA GAA 536Glu Asp Leu Glu Ile Val Leu Ser Ala Arg Ile Ile Lys Val Leu Glu
150 155 160AAC GGG AAT TAT TTC ATC TAT GGG AAT AAG GAA GTG CTA GTG GAT GGG 584Asn Gly Asn Tyr Phe Ile Tyr Gly Asn Lys Glu Val Leu Val Asp Gly
165 170 175GAA AAG CAA ATC CTT AAG GTG AGT GGG GTG ATC CGC CCT TAT GAT ATT 632Glu Lys Gln Ile Leu Lys Val Ser Gly Val Ile Arg Pro Tyr Asp Ile
180 185 190GAA AGG AAT AAC ACC ATC CAA TCC AAG TTT TTA GCC GAC GCT AAG ATT 680Glu Arg Asn Asn Thr Ile Gln Ser Lys Phe Leu Ala Asp Ala Lys Ile195 200 205 210GAA TAC ACG AAT TTA GGG CAT TTG AGC GAT TCC AAT AAG AAG AAA TTC 728Glu Tyr Thr Asn Leu Gly His Leu Ser Asp Ser Asn Lys Lys Lys Phe
215 220 225GCT GCT GAT GCG ATG GAA ACC CAA ATG CCT TAT TAAAAAGAGC AAAGCCTAGC 781Ala Ala Asp Ala Met Glu Thr Gln Met Pro Tyr
230 235ATGAGAGCGA TCGCTATTGT TTTAGCCAGA AGT 814
(2) Sequence 262 data:
(i) sequence characteristics:
(A) length: 237 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 262: met Lys Lys Ala Leu Tyr Leu Gly Ala Val Ala Phe Ser Val Ala Phe 151015 Ser Met Ala Ser Ala Asn Glu Pro Lys Ile Asp Phe Asn Pro Pro Asn
20 25 30Tyr Val Glu Glu Thr Pro Ser Lys Glu Phe Ile Pro Glu Leu Asn Lys
35 40 45Leu Gly Ser Leu Phe Gly Gln Gly Glu Arg Pro Leu Phe Ala Asp Arg
50 55 60Arg Ala Met Lys Pro Asn Asp Leu Ile Thr Ile Ile Val Ser Glu Lys65 70 75 80Ala Ser Ala Asn Tyr Ser Ser Ser Lys Asp Tyr Lys Ser Ala Ser Gly
85 90 95Gly Asn Ser Thr Pro Pro Arg Leu Thr Tyr Asn Gly Leu Asp Glu Arg
100 105 110Lys Lys Lys Glu Ala Glu Tyr Leu Asp Asp Lys Asn Asn Tyr Asn Phe
15 120 125Thr Lys Ser Ser Asn Asn Thr Asn Phe Lys Gly Gly Gly Ser Gln Lys
130 135 140Lys Ser Glu Asp Leu Glu Ile Val Leu Ser Ala Arg Ile Ile Lys Val145 150 155 160Leu Glu Asn Gly Asn Tyr Phe Ile Tyr Gly Asn Lys Glu Val Leu Val
165 170 175Asp Gly Glu Lys Gln Ile Leu Lys Val Ser Gly Val Ile Arg Pro Tyr
180 185 190Asp Ile Glu Arg Asn Asn Thr Ile Gln Ser Lys Phe Leu Ala Asp Ala
195 200 205Lys Ile Glu Tyr Thr Asn Leu Gly His Leu Ser Asp Ser Asn Lys Lys
210 215 220Lys Phe Ala Ala Asp Ala Met Glu Thr Gln Met Pro Tyr225 230 235
(2) Sequence 263 data:
(i) sequence characteristics:
(A) length: 850bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...797
(D) Other information:
(xi) Description of the sequence: sequence 263: TTGGGTAAGA TTAGGAATTG ATTTTAAAGA AAAAGAAAGA AAGGAATTTA ATG AAA 56
Met Lys
1AAA GGT AGT TTG GCA ATC GTT TTA GGA TCG CTA TTA GCG AGT GGG GCG 104Lys Gly Ser Leu Ala Ile Val Leu Gly Ser Leu Leu Ala Ser Gly Ala
5 10 15TTT TAT ACG GCT CTA GCT GAT GGA ATG CCT GCA AAA CAG CAG CAC AAT 152Phe Tyr Thr Ala Leu Ala Asp Gly Met Pro Ala Lys Gln Gln His Asn
20 25 30AAT ACG GGC GAG TCA GTG GAG TTG CAT TTC CAC TAT CCT ATT AAA GGC 200Asn Thr Gly Glu Ser Val Glu Leu His Phe His Tyr Pro Ile Lys Gly35 40 45 50AAG CAA GAG CCT AAA AAC AGC CAT TTA GTC GTT TTG ATC GAA CCT AAA 248Lys Gln Glu Pro Lys Asn Ser His Leu Val Val Leu Ile Glu Pro Lys
55 6065ATA GAG ATC AAT AAA GTT ATC CCT GAA AGT TAT CAA AAA GAG TTT GAG 296lle Glu Ile Asn Lys Val Ile Pro Glu Ser Tyr Gln Lys Glu Phe Glu
70 75 80AAG TCT TTG TTT CTC CAG TTG AGT AGT TTT TTA GAG AGA AAA GGC TAT 344Lys Ser Leu Phe Leu Gln Leu Ser Ser Phe Leu Glu Arg Lys Gly Tyr
85 90 95AGC GTT TCG CAA TTT AAA GAT GCT AGC GAA ATC CCT CAA GAC ATC AAA 392Ser Val Ser Gln Phe Lys Asp Ala Ser Glu Ile Pro Gln Asp Ile Lys
100 105 110GAA AAA GCG TTG CTC GTT TTA CGC ATG GAT GGG AAT GTG GCT ATC TTG 440Glu Lys Ala Leu Leu Val Leu Arg Met Asp Gly Asn Val Ala Ile Leu115 120 125 130GAA GAT ATT GTA GAA GAG AGC GAT GCG CTT AGC GAA GAA AAA GTG ATA 488Glu Asp Ile Val Glu Glu Ser Asp Ala Leu Ser Glu Glu Lys Val Ile
135 140 145GAC ATG TCT TCA GGG TAT TTG AAC TTG AAT TTT GTT GAG CCA AAA AGT 536Asp Met Ser Ser Gly Tyr Leu Asn Leu Asn Phe Val Glu Pro Lys Ser
150 155 160GAA GAT ATT ATC CAT AGT TTT GGT ATT GAT GTT TCA AAG ATT AAG GCT 584Glu Asp Ile Ile His Ser Phe Gly Ile Asp Val Ser Lys Ile Lys Ala
165 170 175GTG ATT GAA AGA GTG GAA TTG CGG CGC ACC AAT TCT GGA GGT TTT GTC 632Val Ile Glu Arg Val Glu Leu Arg Arg Thr Asn Ser Gly Gly Phe Val
180 185 190CCC AAA ACT TTT GTG CAT AGG ATT AAG GAA ACC GAT CAT GAT CAA GCC 680Pro Lys Thr Phe Val His Arg Ile Lys Glu Thr Asp His Asp Gln Ala195 200 205 210ATT AGA AAA ATC ATG AAT CAA GCC TAT CAC AAA GTG ATG GTG CAT ATT 728Ile Arg Lys IleMet Asn Gln Ala Tyr His Lys Val Met Val His Ile
215 220 225ACC AAA GAG TTA AGC AAA AAA CAC ATG GAA CAT TAT GAA AAA GTT TCT 776Thr Lys Glu Leu Ser Lys Lys His Met Glu His Tyr Glu Lys Val Ser
30 235 240AGT GAA ATG AAA AAA CGA AAG TAGTTTTTAA GAAACGAAAA GCTTAAAAAT CATT 831Ser Glu Met Lys Lys Arg Lys
245GAGAGCTATT TTTAAAAAA 850
(2) Sequence 264 data:
(i) sequence characteristics:
(A) length: 249 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 264: met Lys Lys Gly Ser Leu Ala Ile Val Leu Gly Ser Leu Leu Ala Ser 151015 Gly Ala Phe Tyr Thr Ala Leu Ala Asp Gly Met Pro Ala Lys Gln Gln
20 25 30His Asn Asn Thr Gly Glu Ser Val Glu Leu His Phe His Tyr Pro Ile
35 40 45Lys Gly Lys Gln Glu Pro Lys Asn Ser His Leu Val Val Leu Ile Glu
50 55 60Pro Lys Ile Glu Ile Asn Lys Val Ile Pro Glu Ser Tyr Gln Lys Glu65 70 75 80Phe Glu Lys Ser Leu Phe Leu Gln Leu Ser Ser Phe Leu Glu Arg Lys
85 90 95Gly Tyr Ser Val Ser Gln Phe Lys Asp Ala Ser Glu Ile Pro Gln Asp
100 105 110Ile Lys Glu Lys Ala Leu Leu Val Leu Arg Met Asp Gly Asn Val Ala
115 120 125Ile Leu Glu Asp Ile Val Glu Glu Ser Asp Ala Leu Ser Glu Glu Lys
130 135 140Val Ile Asp Met Ser Ser Gly Tyr Leu Asn Leu Asn Phe Val Glu Pro145 150 155 160Lys Ser Glu Asp Ile Ile His Ser Phe Gly Ile Asp Val Ser Lys Ile
165 170 175Lys Ala Val Ile Glu Arg Val Glu Leu Arg Arg Thr Asn Ser Gly Gly
180 185 190Phe Val Pro Lys Thr Phe Val His Arg Ile Lys Glu Thr Asp His Asp
195 200 205Gln Ala Ile Arg Lys Ile Met Asn Gln Ala Tyr His Lys Val Met Val
210 215 220His Ile Thr Lys Glu Leu Ser Lys Lys His Met Glu His Tyr Glu Lys225 230 235 240Val Ser Ser Glu Met Lys Lys Arg Lys
245
(2) Sequence 265 data:
(i) sequence characteristics:
(A) length: 841bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...788
(D) Other information:
(xi) Description of thesequence: sequence 265: TACAAATAGG TATAATCACC AATTCCAATC ATTTAATCAA AGGGAGTTCT ATG AAA 56
Met Lys
1AAT ACT TTC AAA GCG TTT GCC TTT TTA ATT GTA TTT TTT TCA AGC GCT 104Asn Thr Phe Lys Ala Phe Ala Phe Leu Ile Val Phe Phe Ser Ser Ala
5 10 15TTA TTA GCG CAG GAT TTA AAA ATC GCT GCT GCT GCT AAT CTT ACA CGC 152Leu Leu Ala Gln Asp Leu Lys Ile Ala Ala Ala Ala Asn Leu Thr Arg
20 25 30GCT TTA AAA GCC CTT GTT AAA GAA TTT CAA AAA GAA CAC CCC AAA GAC 200Ala Leu Lys Ala Leu Val Lys Glu Phe Gln Lys Glu His Pro Lys Asp35 40 45 50ACT GTT AAT ATT AGC TTT AAT TCT TCA GGC AAA CTC TAC GCT CAA ATC 248Thr Val Asn Ile Ser Phe Asn Ser Ser Gly Lys Leu Tyr Ala Gln Ile
55 60 65ATT CAA AAC GCC CCT TTT GAT TTA TTC ATT TCA GCA GAT ATG ATT AGA 296Ile Gln Asn Ala Pro Phe Asp Leu Phe Ile Ser Ala Asp Met Ile Arg
70 75 80CCT AAA AAG CTT TAT GAT AAA AAA ATA ACC CCT TTT AAA GAA GAA GTC 344Pro Lys Lys Leu Tyr Asp Lys Lys Ile Thr Pro Phe Lys Glu Glu Val
85 90 95TAT GCT AAA GGC GTG TTG GTT TTA TGG AGT GAA GAT CTA AAA ATG GAT 392Tyr Ala Lys Gly Val Leu Val Leu Trp Ser Glu Asp Leu Lys Met Asp
100 105 110TCT TTA GAA ATT CTT AAA AAT CCT AAA ATC AAG CGT ATC GCT ATG GCT 440Ser Leu Glu Ile Leu Lys Asn Pro Lys Ile Lys Arg Ile Ala Met Ala115 120 125 130AAT CCT AAA CTA GCC CCT TAT GGA AAA GCC AGC ATG GAA GTCTTA GAG 488Asn Pro Lys Leu Ala Pro Tyr Gly Lys Ala Ser Met Glu Val Leu Glu
135 140 145AAT TTA AAA CTC ACT CCC AGT CTT AAA TCT AAA ATC GTT TAT GGC GCT 536Asn Leu Lys Leu Thr Pro Ser Leu Lys Ser Lys Ile Val Tyr Gly Ala
150 155 160TCT ATT TCT CAA GCC CAT CAA TTT GTC GCT ACT AAA AAC GCT CAA ATA 584Ser Ile Ser Gln Ala His Gln Phe Val Ala Thr Lys Asn Ala Gln Ile
165 170 175GGC TTT GGA GCG TTA TCC TTG ATG GAT AAA AAA GAT AAA AAC CTC TCT 632Gly Phe Gly Ala Leu Ser Leu Met Asp Lys Lys Asp Lys Asn Leu Ser
180 185 190TAT TTC ATC ATT GAT AAA GCC CTT TAT AAC CCT ATT GAA CAA GCC TTG 680Tyr Phe Ile Ile Asp Lys Ala Leu Tyr Asn Pro Ile Glu Gln Ala Leu195 200 205 210ATT ATC ACT AAA AAT GGG GCT AAC AAC CCT TTA GCC AAA GTC TTT AAA 728Ile Ile Thr Lys Asn Gly Ala Asn Asn Pro Leu Ala Lys Val Phe Lys
215 220 225GAT TTT TTA TTC AGC CCT AAA GCC AGA GCT ATT TTT AAA GAA TAC GGC 776Asp Phe Leu Phe Ser Pro Lys Ala Arg Ala Ile Phe Lys Glu Tyr Gly
230 235 240TAT ATT GTG GAT TAAAACGCAT AAAAAAGGCG AGCAATGGAT CATGAGTTTT TGATT 833Tyr Ile Val Asp
245ACCATGCG 841
(2) Sequence 266 data:
(i) sequence characteristics:
(A) length: 246 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 266: met Lys Asn Thr Phe Lys Ala Phe Ala Phe Leu Ile Val Phe Phe Ser 151015 Ser Ala Leu Leu Ala Gln Asp Leu Lys Ile Ala Ala Ala Ala Asn Leu
20 25 30Thr Arg Ala Leu Lys Ala Leu Val Lys Glu Phe Gln Lys Glu His Pro
35 40 45Lys Asp Thr Val Asn Ile Ser Phe Asn Ser Ser Gly Lys Leu Tyr Ala
50 55 60Gln Ile Ile Gln Asn Ala Pro Phe Asp Leu Phe Ile Ser Ala Asp Met65 70 75 80Ile Arg Pro Lys Lys Leu Tyr Asp Lys Lys Ile Thr Pro Phe Lys Glu
85 90 95Glu Val Tyr Ala Lys Gly Val Leu Val Leu Trp Ser Glu Asp Leu Lys
100 105 110Met Asp Ser Leu Glu Ile Leu Lys Asn Pro Lys Ile Lys Arg Ile Ala
115 120 125Met Ala Asn Pro Lys Leu Ala Pro Tyr Gly Lys Ala Ser Met Glu Val
130 135 140Leu Glu Asn Leu Lys Leu Thr Pro Ser Leu Lys Ser Lys Ile Val Tyr145 150 155 160Gly Ala Ser Ile Ser Gln Ala His Gln Phe Val Ala Thr Lys Asn Ala
165 170 175Gln Ile Gly Phe Gly Ala Leu Ser Leu Met Asp Lys Lys Asp Lys Asn
180 185 190Leu Ser Tyr Phe Ile Ile Asp Lys Ala Leu Tyr Asn Pro Ile Glu Gln
195 200 205Ala Leu Ile Ile Thr Lys Asn Gly Ala Asn Asn Pro Leu Ala Lys Val
210 215 220Phe Lys Asp Phe Leu Phe Ser Pro Lys Ala Arg Ala Ile Phe Lys Glu225 230 235 240Tyr Gly Tyr Ile Val Asp
245
(2) Sequence 267 data:
(i) sequence characteristics:
(A) length: 1459bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1406, 5l
(D) Other information:
(xi) Description of the sequence: sequence 267: AGCCATTTTA TGGCATTTAA AAAAGTTTAA AAATGTTTAA AAGGAATTTT ATG TTA 56
Met Leu
1AGG CTT TTG ATA GGA CTT CTT CTA ATG AGT TTT ATA AGC TTG CAA TCA 104Arg Leu Leu Ile Gly Leu Leu Leu Met Ser Phe Ile Ser Leu Gln Ser
5 10 15GCC TCT TGG CAA GAA CCC TTA AGA GTG AGT ATA GAA TTT GTG GAT TTG 152Ala Ser Trp Gln Glu Pro Leu Arg Val Ser Ile Glu Phe Val Asp Leu
20 25 30CCT AAA AAA ATC ATT CGT TTT CCG GCT CAT GAT TTG CAA GTG GGG GAG 200Pro Lys Lys Ile Ile Arg Phe Pro Ala His Asp Leu Gln Val Gly Glu35 40 45 50TTT GGT TTT GTC GTT ACT AAA CTT TCA GAT TAT GAA ATC GTT AAT TCT248Phe Gly Phe Val Val Thr Lys Leu Ser Asp Tyr Glu Ile Val Asn Ser
55 60 65GAA GTG GTC ATT ATT GCC GTT GAA AAT GGC GTC GCA ACG GCT AAA TTC 296Glu Val Val Ile Ile Ala Val Glu Asn Gly Val Ala Thr Ala Lys Phe
70 75 80AGA GCG TTT GAG TCT ATG AAA CAA AGG CAT TTA CCC ACT CCA AGA ATG 344Arg Ala Phe Glu Ser Met Lys Gln Arg His Leu Pro Thr Pro Arg Met
85 90 95GTC GCT AGA AAG GGT GAT TTA GTC TAT TTT AGG CAA TTC AAC AAC CAA 392Val Ala Arg Lys Gly Asp Leu Val Tyr Phe Arg Gln Phe Asn Asn Gln
100 105 110GCG TTT TTA ATC GCT CCT AAT GAT GAA CTC TAT GAG CAA ATC AGA GCG 440Ala Phe Leu Ile Ala Pro Asn Asp Glu Leu Tyr Glu Gln Ile Arg Ala115 120 125 130ACT AAC ACC GAT ATT AAT TTT ATT AGT TCT GAT TTG TTG GTT ACT TTT 488Thr Asn Thr Asp Ile Asn Phe Ile Ser Ser Asp Leu Leu Val Thr Phe
135 140 145TTG AAT GGG TTT GAC CCA AAA ATC GCT AAT TTA AGG AAA GCG TGC AAC 536Leu Asn Gly Phe Asp Pro Lys Ile Ala Asn Leu Arg Lys Ala Cys Asn
150 155 160GTT TAT AGC GTG GGG GTG ATT TAT ATT GTA ACC ACC AAC ACG CTC AAT 584Val Tyr Ser Val Gly Val Ile Tyr Ile Val Thr Thr Asn Thr Leu Asn
165 170 175ATT TTA AGT TGT GAG AGT TTT GAA ATT TTA GAA AAA AGA GAG CTG GAT 632Ile Leu Ser Cys Glu Ser Phe Glu Ile Leu Glu Lys Arg Glu Leu Asp
180 185 190ACA AGC GGC GTT ACT AAA ACT TCC ACG CCG TTT TTT TCT AGG GTT GAG 680Thr Ser Gly Val Thr Lys Thr Ser Thr Pro Phe Phe Ser Arg Val Glu195 200 205 210GGT ATT GAT GCA GGC ACG CTA GGG AAA CTT TTT TCA GGC AGT CAG TCT 728Gly Ile Asp Ala Gly Thr Leu Gly Lys Leu Phe Ser Gly Ser Gln Ser
215 220 225AAA AAT TAC TTC GCT TAC TAT GAC GCT TTA GTG AAG AAA GAA AAA CGC 776Lys Asn Tyr Phe Ala Tyr Tyr Asp Ala Leu Val Lys Lys Glu Lys Arg
230 235 240AAA GAA GTG AGG ATT AAA AAG AGG GAA GAA AAG ATT GAT TCT AGA GAA 824Lys Glu Val Arg Ile Lys Lys Arg Glu Glu Lys Ile Asp Ser Arg Glu
245 250 255ATT AAA CGA GAA ATC AAG CAA GAG GCC ATT AAA GAG CCT AAA AAA GCC 872Ile Lys Arg Glu Ile Lys Gln Glu Ala Ile Lys Glu Pro Lys Lys Ala
260 265 270AAT CAA GGC ACA CAA AAC GCT CCT ACT TTA GAA GAG AAA AAC TAC CAA 920Asn Gln Gly Thr Gln Asn Ala Pro Thr Leu Glu Glu Lys Asn Tyr Gln275 280 285 290AAA GCA GAG CGC AAA CTT GAT GCT AAA GAA GAA AGG CGT TAT TTG AGA 968Lys Ala Glu Arg Lys Leu Asp Ala Lys Glu Glu Arg Arg Tyr Leu Arg
295 300 305GAT GAA AGG AAA AAA GCC AAA GCC ACC AAA AAG GCT ATG GAA TTT GAA 1016Asp Glu Arg Lys Lys Ala Lys Ala Thr Lys Lys Ala Met Glu Phe Glu
310 315 320GAA AGA GAA AAA GAG CAT GAT GAA AGG GAC GAA CAA GAG ACT GAA GGA 1064Glu Arg Glu Lys Glu His Asp Glu Arg Asp Glu Gln Glu Thr Glu Gly
325 330 335AGA AGA AAA GCT TTA GAA ATG GAT AAA GGC GAT AAA AAA GAA GAA AGA 1112Arg Arg Lys Ala Leu Glu Met Asp Lys Gly Asp Lys Lys Glu Glu Arg
340 345 350GTCAAA CCC AAA GAA AAT GAG CGA GAA ATC AAG CAA GAA GCC ATT AAA 1160Val Lys Pro Lys Glu Asn Glu Arg Glu Ile Lys Gln Glu Ala Ile Lys355 360 365 370GAG CCA AGT GAT GGA AAT AAC GCC ACC CAA CAA GGC GAA AAA CAA AAC 1208Glu Pro Ser Asp Gly Asn Asn Ala Thr Gln Gln Gly Glu Lys Gln Asn
375 380 385GCT CCT AAA GAG AAC AAC GCT CAA AAA GAA GAG AAT AAA CCA AAT TCT 1256Ala Pro Lys Glu Asn Asn Ala Gln Lys Glu Glu Asn Lys Pro Asn Ser
390 395 400AAA GAA GAA AAA CGC CGC TTG AAA GAA GAA AAG AAA AAA GCC AAA GCC 1304Lys Glu Glu Lys Arg Arg Leu Lys Glu Glu Lys Lys Lys Ala Lys Ala
405 410 415GAA CAA AGA GCG AGA GAA TTT GAA CAA AGA GCG AGA GAG CAT CAA GAA 1352Glu Gln Arg Ala Arg Glu Phe Glu Gln Arg Ala Arg Glu His Gln Glu
420 425 430AGA GAT GAA AAA GAG CTT GAA GAG CGA AGA AAG GCG CTA GAA GCG GGT 1400Arg Asp Glu Lys Glu Leu Glu Glu Arg Arg Lys Ala Leu Glu Ala Gly435 440 445 450AAA AAA TAACATGTTA GACCAACAAC ACATCCAATA CTTTAAAAAC CTAGTAGGGG GA 1458Lys Lys
1459
(2) Sequence 268 data:
(i) sequence characteristics:
(A) length: 452 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 268: met Leu Arg Leu Leu Ile Gly Leu Leu Leu Met Ser Phe Ile Ser Leu 151015 Gln Ser Ala Ser Trp Gln Glu Pro Leu Arg Val Ser Ile Glu Phe Val
20 25 30Asp Leu Pro Lys Lys Ile Ile Arg Phe Pro Ala His Asp Leu Gln Val
35 40 45Gly Glu Phe Gly Phe Val Val Thr Lys Leu Ser Asp Tyr Glu Ile Val
50 55 60Asn Ser Glu Val Val Ile Ile Ala Val Glu Asn Gly Val Ala Thr Ala65 70 75 80Lys Phe Arg Ala Phe Glu Ser Met Lys Gln Arg His Leu Pro Thr Pro
85 90 95Arg Met Val Ala Arg Lys Gly Asp Leu Val Tyr Phe Arg Gln Phe Asn
100 105 110Asn Gln Ala Phe Leu Ile Ala Pro Asn Asp Glu Leu Tyr Glu Gln Ile
115 120 125Arg Ala Thr Asn Thr Asp Ile Asn Phe Ile Ser Ser Asp Leu Leu Val
130 135 140Thr Phe Leu Asn Gly Phe Asp Pro Lys Ile Ala Asn Leu Arg Lys Ala145 150 155 160Cys Asn Val Tyr Ser Val Gly Val Ile Tyr Ile Val Thr Thr Asn Thr
165 170 175Leu Asn Ile Leu Ser Cys Glu Ser Phe Glu Ile Leu Glu Lys Arg Glu
180 185 190Leu Asp Thr Ser Gly Val Thr Lys Thr Ser Thr Pro Phe Phe Ser Arg
195 200 205Val Glu Gly Ile Asp Ala Gly Thr Leu Gly Lys Leu Phe Ser Gly Ser
210 215 220Gln Ser Lys Asn Tyr Phe Ala Tyr Tyr Asp Ala Leu Val Lys Lys Glu225 230 235 240Lys Arg Lys Glu Val Arg Ile Lys Lys Arg Glu Glu Lys Ile Asp Ser
245 250 255Arg Glu Ile Lys Arg Glu Ile Lys Gln Glu Ala Ile Lys Glu Pro Lys
260 265 270Lys Ala Asn Gln Gly Thr Gln Asn Ala Pro Thr Leu Glu Glu Lys Asn
275 280 285Tyr Gln Lys Ala Glu Arg Lys Leu Asp Ala Lys Glu Glu Arg Arg Tyr
290 295 300Leu Arg Asp Glu Arg Lys Lys Ala Lys Ala Thr Lys Lys Ala Met Glu305 310 315 320Phe Glu Glu Arg Glu Lys Glu His Asp Glu Arg Asp Glu Gln Glu Thr
325 330 335Glu Gly Arg Arg Lys Ala Leu Glu Met Asp Lys Gly Asp Lys Lys Glu
340 345 350Glu Arg Val Lys Pro Lys Glu Asn Glu Arg Glu Ile Lys Gln Glu Ala
355 360 365Ile Lys Glu Pro Ser Asp Gly Asn Asn Ala Thr Gln Gln Gly Glu Lys
370 375 380Gln Asn Ala Pro Lys Glu Asn Asn Ala Gln Lys Glu Glu Asn Lys Pro385 390 395 400Asn Ser Lys Glu Glu Lys Arg Arg Leu Lys Glu Glu Lys Lys Lys Ala
405 410 415Lys Ala Glu Gln Arg Ala Arg Glu Phe Glu Gln Arg Ala Arg Glu His
420 425 430Gln Glu Arg Asp Glu Lys Glu Leu Glu Glu Arg Arg Lys Ala Leu Glu
435 440 445Ala Gly Lys Lys
450
(2) Sequence 269 data:
(i) sequence characteristics:
(A) length: 995bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 74...943
(D) Other information:
(xi) Description of the sequence: sequence 269: GGCCTATGAC GATTGTCTCG CTTTTAGAAA ACACTCTAAT CGCTTTTGAA AAACAACAAA 60GGAAGGGATT TTA ATG AAA TTT TTA CGC TCT GTT TAT GCA TTT TGC TCC 109
Met Lys Phe Leu Arg Ser Val Tyr Ala Phe Cys Ser
1 5 10AGT TGG GTA GGG ACG ATT GTT ATT GTG CTG TTG GTT ATC TTT TTT ATC 157Ser Trp Val Gly Thr Ile Val Ile Val Leu Leu Val Ile Phe Phe Ile
15 20 25GCG CAA GCC TTT ATC ATT CCC TCT CGC TCT ATG GTT GGC ACG CTC TAT 205Ala Gln Ala Phe Ile Ile Pro Ser Arg Ser Met Val Gly Thr Leu Tyr
30 35 40GAG GGC GAC ATG CTC TTT GTC AAA AAG TTT TCT TAC GGC ATA CCC ATT 253Glu Gly Asp Met Leu Phe Val Lys Lys Phe Ser Tyr Gly Ile Pro Ile45 50 55 60CCT AAA ATC CCA TGG ATT GAG CTT CCT GTT ATG CCT GAT TTT AAA AAT 301Pro Lys Ile Pro Trp Ile Glu Leu Pro Val Met Pro Asp Phe Lys Asn
65 70 75AAC GGA CAT TTG ATA GAG GGG GAT CGC CCT AAG CGT GGC GAA GTG GTG 349Asn Gly His Leu Ile Glu Gly Asp Arg Pro Lys Arg Gly Glu Val Val
80 85 90GTG TTT ATC CCT CCC CAT GAA AAA AAG TCT TAC TAT GTT AAA AGG AAT 397Val Phe Ile Pro Pro His Glu Lys Lys Ser Tyr Tyr Val Lys Arg Asn
95 100 105TTT GCC ATT GGA GGC GAT GAG GTG TTG TTC ACT AAT GAG GGT TTT TAT 445Phe Ala Ile Gly Gly Asp Glu Val Leu Phe Thr Asn Glu Gly Phe Tyr
110 115 120TTG CAC CCT TTT GAG AGC GAC ACG GAC AAA AAT TAC ATC GCT AAA CAT 493Leu His Pro Phe Glu Ser Asp Thr Asp Lys Asn Tyr Ile Ala Lys His125 130 135 140TAC CCT AAC GCC ATG ACA AAA GAA TTT ATG GGT AAA ATT TTT GTT TTA 541Tyr Pro Asn Ala Met Thr Lys Glu Phe Met Gly Lys Ile Phe Val Leu
145 150 155AAC CCT TAT AAA AAT GAG CAT CCG GGT ATC CAT TAC CAA AAA GAC AAT 589Asn Pro Tyr Lys Asn Glu His Pro Gly Ile His Tyr Gln Lys Asp Asn
160 165 170GAA ACC TTC CAC TTA ATG GAG CAA TTA GCC ACT CAA GGC GCA GAA GCT 637Glu Thr Phe His Leu Met Glu Gln Leu Ala Thr Gln Gly Ala Glu Ala
175 180 185AAT ATC AGC ATG CAA CTC ATT CAA ATG GAG GGC GAA AAG GTG TTT TAT 685Asn Ile Ser Met Gln Leu Ile Gln Met Glu Gly Glu Lys Val Phe Tyr
190 195 200AAG AAA ATC AAT GAC GAT GAA TTT TTC ATG ATC GGC GAC AAC AGA GAC 733Lys Lys Ile Asn Asp Asp Glu Phe Phe Met Ile Gly Asp Asn Arg Asp205 210 215 220AAT TCT AGC GAC TCG CGC TTT TGG GGG AGT GTG GCT TAT AAA AAC ATC 781Asn Ser Ser Asp Ser Arg Phe Trp Gly Ser Val Ala Tyr Lys Asn Ile
225 230 235GTGGGT TCG CCA TGG TTT GTT TAT TTC AGT TTG AGT TTA AAA AAT AGC 829Val Gly Ser Pro Trp Phe Val Tyr Phe Ser Leu Ser Leu Lys Asn Ser
240 245 250CTA GAA ATG GAT GCA GAA AAT AAC CCT AAA AAA CGC TAT CTG GTG CGT 877Leu Glu Met Asp Ala Glu Asn Asn Pro Lys Lys Arg Tyr Leu Val Arg
255 260 265TGG GAA CGC ATG TTT AAA AGC GTT GGA GGC TTA GAA AAA ATC ATT AAA 925Trp Glu Arg Met Phe Lys Ser Val Gly Gly Leu Glu Lys Ile Ile Lys
270 275 280AAA GAA AAC GCA ACG CAT TAAGGTTTTT TGTGCAATTT TTTGATTTCT CTTTAGAA 981Lys Glu Asn Ala Thr His285 290AGTTTTATTA CCAC 995
(2) Sequence 270 data:
(i) sequence characteristics:
(A) length: 290 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 270: met Lys Phe Leu Arg Ser Val Tyr Ala Phe Cys Ser Ser Trp Val Gly 151015 Thr Ile Val Ile Val Leu Leu Val Ile Phe Phe Ile Ala Gln Ala Phe
20 25 30Ile Ile Pro Ser Arg Ser Met Val Gly Thr Leu Tyr Glu Gly Asp Met
35 40 45Leu Phe Val Lys Lys Phe Ser Tyr Gly Ile Pro Ile Pro Lys Ile Pro
50 55 60Trp Ile Glu Leu Pro Val Met Pro Asp Phe Lys Asn Asn Gly His Leu65 7075 80Ile Glu Gly Asp Arg Pro Lys Arg Gly Glu Val Val Val Phe Ile Pro
85 90 95Pro His Glu Lys Lys Ser Tyr Tyr Val Lys Arg Asn Phe Ala Ile Gly
100 105 110Gly Asp Glu Val Leu Phe Thr Asn Glu Gly Phe Tyr Leu His Pro Phe
115 120 125Glu Ser Asp Thr Asp Lys Asn Tyr Ile Ala Lys His Tyr Pro Asn Ala
130 135 140Met Thr Lys Glu Phe Met Gly Lys Ile Phe Val Leu Asn Pro Tyr Lys145 150 155 160Asn Glu His Pro Gly Ile His Tyr Gln Lys Asp Asn Glu Thr Phe His
165 170 175Leu Met Glu Gln Leu Ala Thr Gln Gly Ala Glu Ala Asn Ile Ser Met
180 185 190Gln Leu Ile Gln Met Glu Gly Glu Lys Val Phe Tyr Lys Lys Ile Asn
195 200 205Asp Asp Glu Phe Phe Met Ile Gly Asp Asn Arg Asp Asn Ser Ser Asp
210 215 220Ser Arg Phe Trp Gly Ser Val Ala Tyr Lys Asn Ile Val Gly Ser Pro225 230 235 240Trp Phe Val Tyr Phe Sar Leu Ser Leu Lys Asn Ser Leu Glu Met Asp
245 250 255Ala Glu Asn Asn Pro Lys Lys Arg Tyr Leu Val Arg Trp Glu Arg Met
260 265 270Phe Lys Ser Val Gly Gly Leu Glu Lys Ile Ile Lys Lys Glu Asn Ala
275 280 285Thr His
290
(2) Data of sequence 271:
(i) sequence characteristics:
(A) length: 2473bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 548...2419
(D) Other information:
(xi) Description of the sequence: sequence 271: GATACAATTC CAAATTTAAA AAACAAACGA TTTAATTCAA ATTTAAGGAA AAATTTTGAT 60TACAGTGGTT AAACGAAACG GGCGCATTGA GCCTTTGGAC ATTACCAAAA TCCAAAAATA 120CACTAAGGAC GCTACGGACA ATTTAGAGGG CGTGAGCCAA AGTGAGCTGG AAGTGGATGC 180GAGGTTGCAA TTCAGGGACA AGATCACTAC TGAAGAAATC CAACAAACTT TGATTAAAAC 240CGCTGTGGAT AAGATAGATA TTGACACGCC TAATTGGAGT TTTGTCGCCT CAAGGCTTTT 300TTTGTATGAT TTATACCATA AAGTAAGTGG TTTTACAGGG TATAGGCATT TGAAAGAGTA 360TTTTGAAAAC GCTGAAGAAA AGGGCCGCAT CCTTAAGGGC TTTAAGGAAA AATTTGATCT 420AGAGTTTTTA AATAGCCAGA TCAAGCCTGA AAGGGATTTC CAATTCAATT ATTTAGGGAT 480TAAAACCTTG TATGATCGCT ATTTGTTAAA AGACGCTAAC AACAACCCTA TTGAATTGCC 540CCAACAC ATG TTT ATG AGC ATT GCG ATG TTT TTA GCA CAA AAC GAA CAA 589
Met Phe Met Ser Ile Ala Met Phe Leu Ala Gln Asn Glu Gln
1 5 10GAA CCC AAT AAA ATC GCC TTA GAA TTT TAT GAA GTT TTG AGC AAG TTT 637Glu Pro Asn Lys Ile Ala Leu Glu Phe Tyr Glu Val Leu Ser Lys Phe15 20 25 30GAA GCG ATG TGC GCG ACC CCC ACT CTA GCG AAC GCC CGC ACC ACC AAA 685Glu Ala Met Cys Ala Thr Pro Thr Leu Ala Asn Ala Arg Thr Thr Lys
35 40 45CAC CAG CTC AGC TCA TGC TATATT GGC AGC ACG CCG GAT AAT ATT GAG 733His Gln Leu Ser Ser Cys Tyr Ile Gly Ser Thr Pro Asp Asn Ile Glu
50 55 60GGG ATT TTT GAC AGC TAT AAG GAA ATG GCG CTG TTG TCC AAA TAC GGC 781Gly Ile Phe Asp Ser Tyr Lys Glu Met Ala Leu Leu Ser Lys Tyr Gly
65 70 75GGA GGG ATT GGC TGG GAT TTT TCT TTG GTG CGC TCT ATT GGG AGT TAT 829Gly Gly Ile Gly Trp Asp Phe Ser Leu Val Arg Ser Ile Gly Ser Tyr
80 85 90ATT GAT GGG CAT AAA AAT GCG AGC GCT GGC ACG ATC CCT TTT TTA AAA 877Ile Asp Gly His Lys Asn Ala Ser Ala Gly Thr Ile Pro Phe Leu Lys95 100 105 110ATC GCT AAC GAT GTG GCG ATT GCG GTG GAT CAA TTA GGC ACA CGA AAG 925Ile Ala Asn Asp Val Ala Ile Ala Val Asp Gln Leu Gly Thr Arg Lys
115 120 125GGC GCG ATT GCG GTG TAT TTG GAA ATT TGG CAC ATT GAT GTG ATG GAG 973Gly Ala Ile Ala Val Tyr Leu Glu Ile Trp His Ile Asp Val Met Glu
130 135 140TTC ATT GAT TTA AGG AAA AAT AGC GGC GAT GAA AGG CGA AGA GCG CAT 1021Phe Ile Asp Leu Arg Lys Asn Ser Gly Asp Glu Arg Arg Arg Ala His
145 150 155GAT TTA TTC CCG GCT CTT TGG GTG TGC GAT TTG TTT TTG AAA AGG GTT 1069Asp Leu Phe Pro Ala Leu Trp Val Cys Asp Leu Phe Leu Lys Arg Val
160 165 170TTA GAA GAT GCG ATG TGG ACT TTA TTT GAC CCT TAT GAG TGT AAG GAT 1117Leu Glu Asp Ala Met Trp Thr Leu Phe Asp Pro Tyr Glu Cys Lys Asp175 180 185 190TTG ACT GAG CTT TAT GGG CAG GAT TTT GAA AAA CGC TAT TTA GAG TAT 1165Leu Thr Glu Leu Tyr Gly Gln Asp Phe Glu Lys Arg Tyr Leu Glu Tyr
195 200 205GAA AAA GAT CCC AAG ATC ATT AAG GAA TAC ATT AAC GCT AAA GAT TTA 1213Glu Lys Asp Pro Lys Ile Ile Lys Glu Tyr Ile Asn Ala Lys Asp Leu
210 215 220TGG AAA AAA ATC TTA ATG AAT TAT TTT GAA GCC GGT TTG CCT TTC TTA 1261Trp Lys Lys Ile Leu Met Asn Tyr Phe Glu Ala Gly Leu Pro Phe Leu
225 230 235GCC TTT AAA GAT AAC GCC AAT CGG TGC AAC CCA AAC GCT CAT GCA GGA 1309Ala Phe Lys Asp Asn Ala Asn Arg Cys Asn Pro Asn Ala His Ala Gly
240 245 250ATC ATT CGA TCC AGC AAT CTA TGC ACG GAG ATT TTC CAA AAT ACC GCG 1357Ile Ile Arg Ser Ser Asn Leu Cys Thr Glu Ile Phe Gln Asn Thr Ala255 260 265 270CCT AAC CAC TAC TAC ATG CAA ATA GAA TAC ACC GAC GGC ACC ATA GAG 1405Pro Asn His Tyr Tyr Met Gln Ile Glu Tyr Thr Asp Gly Thr Ile Glu
275 280 285TTT TTT GAA GAA AAA GAG TTG GTA ACG ACA GAT AGT AAT ATC ACT AAA 1453Phe Phe Glu Glu Lys Glu Leu Val Thr Thr Asp Ser Asn Ile Thr Lys
290 295 300TGC GCT AAC AAG CTC ACT AGC ACC GAT ATT CTA AAG GGC AAG CCA ATC 1501Cys Ala Asn Lys Leu Thr Ser Thr Asp Ile Leu Lys Gly Lys Pro Ile
305 310 315TAT ATC GCT ACT AAA GTC GCT AAA GAC GGG CAA ACG GCG GTG TGC AAT 1549Tyr Ile Ala Thr Lys Val Ala Lys Asp Gly Gln Thr Ala Val Cys Asn
320 325 330CTG GCG AGC ATC AAT TTA AGC AAA ATC AAC ACT GAA GAA GAC ATT AAA 1597Leu Ala Ser Ile Asn Leu Ser Lys Ile Asn Thr Glu Glu Asp Ile Lys335 340 345 350AGG GTT GTG CCG ATC ATG GTC AGG CTT TTA GAC AAT GTG ATT GAT TTG 1645Arg Val Val Pro Ile Met Val Arg Leu Leu Asp Asn Val Ile Asp Leu
355 360 365AAT TTC TAC CCT AAC CGC AAA GTC AAA GCC ACT AAT TTA CAA AAT AGG 1693Asn Phe Tyr Pro Asn Arg Lys Val Lys Ala Thr Asn Leu Gln Asn Arg
370 375 380GCC ATA GGG TTA GGG GTT ATG GGT GAA GCG CAA ATG CTC GCA GAA CAC 1741Ala Ile Gly Leu Gly Val Met Gly Glu Ala Gln Met Leu Ala Glu His
385 390 395CAA ATC GCT TGG GGG TCT AAA GAG CAT TTA GAA AAA ATT GAC GCT TTA 1789Gln Ile Ala Trp Gly Ser Lys Glu His Leu Glu Lys Ile Asp Ala Leu
400 405 410ATG GAG CAA ATC AGC TAC CAT GCG ATT GAC ACG AGC GCG AAT TTA GCG 1837Met Glu Gln Ile Ser Tyr His Ala Ile Asp Thr Ser Ala Asn Leu Ala415 420 425 430AAA GAA AAA GGG GTT TAT AAG GAT TTT GAA AAT TCA GAA TGG AGT AAG 1885Lys Glu Lys Gly Val Tyr Lys Asp Phe Glu Asn Ser Glu Trp Ser Lys
435 440 445GGG ATT TTC CCC ATT GAT AAA GCC AAT AAT GAA GCC TTA AAG CTC ACC 1933Gly Ile Phe Pro Ile Asp Lys Ala Asn Asn Glu Ala Leu Lys Leu Thr
450 455 460GAA AAA GGG CTT TTT AAT CAC GCT TGC GAT TGG CAA GGT TTG AGG GAA 1981Glu Lys Gly Leu Phe Asn His Ala Cys Asp Trp Gln Gly Leu Arg Glu
465 470 475AAA GTC AAA GCC AAT GGC ATG CGT AAT GGC TAT TTA ATG GCG ATC GCT 2029Lys Val Lys Ala Asn Gly Met Arg Asn Gly Tyr Leu Met Ala Ile Ala
480 485 490CCC ACA AGC TCC ATT TCT ATT TTA GTA GGC ACA ACC CAA ACG ATT GAA 2077Pro Thr Ser Ser Ile Ser Ile Leu Val Gly Thr Thr Gln Thr Ile Glu495 500 505 510CCC ATT TAT AAG AAA AAA TGG TTT GAA GAA AAT TTG AGC GGG CTT ATT 2125Pro Ile Tyr Lys Lys Lys Trp Phe Glu Glu Asn Leu Ser Gly Leu Ile
515 520 525CCT GTT GTG GTG CCT AAT TTG AAT GTA GAA ACC TGG AAT TTT TAC ACA 2173Pro Val Val Val Pro Asn Leu Asn Val Glu Thr Trp Asn Phe Tyr Thr
530 535 540TCA GCC TAT GAT ATT GAC GCT AAA GAT TTG ATT AAA GCA GCG GCC GTG 2221Ser Ala Tyr Asp Ile Asp Ala Lys Asp Leu Ile Lys Ala Ala Ala Val
545 550 555CGC CAA AAG TGG ATT GAT CAA GGC CAA AGC CTT AAT GTG TTT TTA CGC 2269Arg Gln Lys Trp Ile Asp Gln Gly Gln Ser Leu Asn Val Phe Leu Arg
560 565 570ATA GAA AAC GCC AGC GGT AAA ACC TTG CAT GAC ATC TAC ACG CTC GCT 2317Ile Glu Asn Ala Ser Gly Lys Thr Leu His Asp Ile Tyr Thr Leu Ala575 580 585 590TGG AAA TTA GGA CTC AAA TCC ACT TAT TAT TTG CGC AGC GAA AGC CCT 2365Trp Lys Leu Gly Leu Lys Ser Thr Tyr Tyr Leu Arg Ser Glu Ser Pro
595 600 605AGC ATA GAT GAA AAA AGC GTG TTG GAT CGA TCG GTG GAG TGT TTT AAT 2413Ser Ile Asp Glu Lys Ser Val Leu Asp Arg Ser Val Glu Cys Phe Asn
610 615 620TGC CAA TAATATAAGC TTAAATAAGC TAATCTTTGC TAAAATGAGA TTTAAAATTA TT 2471Cys GlnTA 2473
(2) Data of sequence 272:
(i) sequence characteristics:
(A) length: 624 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 272: met Phe Met Ser Ile Ala Met Phe Leu Ala Gln Asn Glu Gln Glu Pro 151015 Asn Lys Ile Ala Leu Glu Phe Tyr Glu Val Leu Ser Lys Phe Glu Ala
20 25 30Met Cys Ala Thr Pro Thr Leu Ala Asn Ala Arg Thr Thr Lys His Gln
35 40 45Leu Ser Ser Cys Tyr Ile Gly Ser Thr Pro Asp Asn Ile Glu Gly Ile
50 55 60Phe Asp Ser Tyr Lys Glu Met Ala Leu Leu Ser Lys Tyr Gly Gly Gly65 70 75 80Ile Gly Trp Asp Phe Ser Leu Val Arg Ser Ile Gly Ser Tyr Ile Asp
85 90 95Gly His Lys Asn Ala Ser Ala Gly Thr Ile Pro Phe Leu Lys Ile Ala
100 105 110Asn Asp Val Ala Ile Ala Val Asp Gln Leu Gly Thr Arg Lys Gly Ala
115 120 125Ile Ala Val Tyr Leu Glu Ile Trp His Ile Asp Val Met Glu Phe Ile
130 135 140Asp Leu Arg Lys Asn Ser Gly Asp Glu Arg Arg Arg Ala His Asp Leu145 150 155 160Phe Pro Ala Leu Trp Val Cys Asp Leu Phe Leu Lys Arg Val Leu Glu
165 170 175Asp Ala Met Trp Thr Leu Phe Asp Pro Tyr Glu Cys Lys Asp Leu Thr
180 185 190Glu Leu Tyr Gly Gln Asp Phe Glu Lys Arg Tyr Leu Glu Tyr Glu Lys
195 200 205Asp Pro Lys Ile Ile Lys Glu Tyr Ile Asn Ala Lys Asp Leu Trp Lys
210 215 220Lys Ile Leu Met Asn Tyr Phe Glu Ala Gly Leu Pro Phe Leu Ala Phe225 230 235 240Lys Asp Asn Ala Asn Arg Cys Asn Pro Asn Ala His Ala Gly Ile Ile
245 250 255Arg Ser Ser Asn Leu Cys Thr Glu Ile Phe Gln Asn Thr Ala Pro Asn
260 265 270His Tyr Tyr Met Gln Ile Glu Tyr Thr Asp Gly Thr Ile Glu Phe Phe
275 280 285Glu Glu Lys Glu Leu Val Thr Thr Asp Ser Asn Ile Thr Lys Cys Ala
290 295 300Asn Lys Leu Thr Ser Thr Asp Ile Leu Lys Gly Lys Pro Ile Tyr Ile305 310 315 320Ala Thr Lys Val Ala Lys Asp Gly Gln Thr Ala Val Cys Asn Leu Ala
325 330 335Ser Ile Asn Leu Ser Lys Ile Asn Thr Glu Glu Asp Ile Lys Arg Val
340 345 350Val Pro Ile Met Val Arg Leu Leu Asp Asn Val Ile Asp Leu Asn Phe
355 360 365Tyr Pro Asn Arg Lys Val Lys Ala Thr Asn Leu Gln Asn Arg Ala Ile
370 375 380Gly Leu Gly Val Met Gly Glu Ala Gln Met Leu Ala Glu His Gln Ile385 390 395 400Ala Trp Gly Ser Lys Glu His Leu Glu Lys Ile Asp Ala Leu Met Glu
405 410 415Gln Ile Ser Tyr His Ala Ile Asp Thr Ser Ala Asn Leu Ala Lys Glu
420 425 430Lys Gly Val Tyr Lys Asp Phe Glu Asn Ser Glu Trp Ser Lys Gly Ile
435 440 445Phe Pro Ile Asp Lys Ala Asn Asn Glu Ala Leu Lys Leu Thr Glu Lys
450 455 460Gly Leu Phe Asn His Ala Cys Asp Trp Gln Gly Leu Arg Glu Lys Val465 470 475 480Lys Ala Asn Gly Met Arg Asn Gly Tyr Leu Met Ala Ile Ala Pro Thr
485 490 495Ser Ser Ile Ser Ile Leu Val Gly Thr Thr Gln Thr Ile Glu Pro Ile
500 505 510Tyr Lys Lys Lys Trp Phe Glu Glu Asn Leu Ser Gly Leu Ile Pro Val
515 520 525Val Val Pro Asn Leu Asn Val Glu Thr Trp Asn Phe Tyr Thr Ser Ala
530 535 540Tyr Asp Ile Asp Ala Lys Asp Leu Ile Lys Ala Ala Ala Val Arg Gln545 550 555 560Lys Trp Ile Asp Gln Gly Gln Ser Leu Asn Val Phe Leu Arg Ile Glu
565 570 575Asn Ala Ser Gly Lys Thr Leu His Asp Ile Tyr Thr Leu Ala Trp Lys
580 585 590Leu Gly Leu Lys Ser Thr Tyr Tyr Leu Arg Ser Glu Ser Pro Ser Ile
595 600 605Asp Glu Lys Ser Val Leu Asp Arg Ser Val Glu Cys Phe Asn Cys Gln
610 615 620
(2) Sequence 273 data:
(i) sequence characteristics:
(A) length: 1440bp
(B) Type (2): nucleicacids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 56...1390
(D) Other information: (xi) sequence description: sequence 273: GCAAAATTCT AGCCTTAAAT CTTTGATGAA ACGAAGTCAA ATTATAAGAT AAGGC ATG 58
Met
1 TTA AAA TTC CCT AAA ATG AGT TTA AGG ATT TTA ATG CTT TCT GTC ATC 106Leu Lys Phe Pro Lys Met Ser Leu Arg Ile Leu Met Leu Ser Val Ile
5 10 15ATA CTG GCC GCT GGT AAA GGC ACT CGC ATG CGT TCT AGC CTG CCT AAA 154Ile Leu Ala Ala Gly Lys Gly Thr Arg Met Arg Ser Ser Leu Pro Lys
20 25 30ACT TTA CAC ACC ATT TGT GGG GAG CCT ATG TTG TTT TAC ATT TTA GAA 202Thr Leu His Thr Ile Cys Gly Glu Pro Met Leu Phe Tyr Ile Leu Glu
35 40 45ACG GCT TTT TCA ATC AGC GAT GAT GTG CAT CTT ATC TTA CAC CAC CAA 250Thr Ala Phe Ser Ile Ser Asp Asp Val His Leu Ile Leu His His Gln50 55 60 65CAA GAA CGC ATT AAA GAA GCG GTG TTG GAG CGT TTT AAG GGC GTC ATT 298Gln Glu Arg Ile Lys Glu Ala Val Leu Glu Arg Phe Lys Gly Val Ile
70 75 80TTT CAC ACT CAA ATT GTG GAA AAA TAT TCA GGG ACA GGT GGG GCT ATC 346Phe His Thr Gln Ile Val Glu Lys Tyr Ser Gly Thr Gly Gly Ala Ile
85 90 95ATG CAA AAA GATAAA ACG CCT ATT TCT ACG AAA CAT GAG CGG GTT TTG 394Met Gln Lys Asp Lys Thr Pro Ile Ser Thr Lys His Glu Arg Val Leu
100 105 110ATT TTG AAT GCG GAC ATG CCT TTA ATC ACT AAA GAC GCT CTC GCC CCC 442Ile Leu Asn Ala Asp Met Pro Leu Ile Thr Lys Asp Ala Leu Ala Pro
115 120 125TTA TTA GAA AGC AAG AAT AAC GCT ATA GGC TTA CTC CAT TTA GCT GAC 490Leu Leu Glu Ser Lys Asn Asn Ala Ile Gly Leu Leu His Leu Ala Asp130 135 140 145CCT AAA GGT TAT GGG CGC GTT GTT TTA GAA AAC CAT CAG GTT AAA AAG 538Pro Lys Gly Tyr Gly Arg Val Val Leu Glu Asn His Gln Val Lys Lys
150 155 160ATT GTA GAA GAA AAG GAC GCT AAT GAT GAA GAA AAA GAA ATT AAA AGC 586Ile Val Glu Glu Lys Asp Ala Asn Asp Glu Glu Lys Glu Ile Lys Ser
165 170 175GTG AAT GCT GGC GTG TAT GGG TTT GAA AGG GAT TTT TTA GAA AAA TAC 634Val Asn Ala Gly Val Tyr Gly Phe Glu Arg Asp Phe Leu Glu Lys Tyr
180 185 190TTA CCC AAG CTC CAT GAC CAA AAC GCC CAA AAA GAA TAC TAC CTC ACG 682Leu Pro Lys Leu His Asp Gln Asn Ala Gln Lys Glu Tyr Tyr Leu Thr
195 200 205GAT TTA ATC GCT CTA GGG ATC AAT GAA AAC GAA ACA ATT GAC GCT ATT 730Asp Leu Ile Ala Leu Gly Ile Asn Glu Asn Glu Thr Ile Asp Ala Ile210 215 220 225TTC TTA AAA GAA GAG TGT TTT TTA GGG GTG AAT AGC CAA ACA GAA AGG 778Phe Leu Lys Glu Glu Cys Phe Leu Gly Val Asn Ser Gln Thr Glu Arg
230 235 240GCG AAA GCT GAA GAA ATC ATG CTA GAA AGA CTG CGC AAA AAC GCC ATG 826Ala Lys Ala Glu Glu Ile Met Leu Glu Arg Leu Arg Lys Asn Ala Met
245 250 255GAC TTG GGG GTA GTG ATG CAA TTG CCT AAT AGC ATT TAT TTA GAA AAA 874Asp Leu Gly Val Val Met Gln Leu Pro Asn Ser Ile Tyr Leu Glu Lys
260 265 270GGC GTG AGT TTT AAG GGG GAG TGC GTT TTA GAG CAA GGG GTG CGT TTG 922Gly Val Ser Phe Lys Gly Glu Cys Val Leu Glu Gln Gly Val Arg Leu
275 280 285ATT GGG AAT TGT TTG ATA GAA AAC GCG CAT ATT AAG GCT TAT AGC GTG 970Ile Gly Asn Cys Leu Ile Glu Asn Ala His Ile Lys Ala Tyr Ser Val290 295 300 305ATA GAA GAG AGC CAG ATT GTT AAT AGC AGT GTG GGG CCG TTT GCC CAT 1018Ile Glu Glu Ser Gln Ile Val Asn Ser Ser Val Gly Pro Phe Ala His
310 315 320GCG CGC CCT AAA AGC GTG ATT TGT AAT AGC CAT GTG GGG AAT TTT GTA 1066Ala Arg Pro Lys Ser Val Ile Cys Asn Ser His Val Gly Asn Phe Val
325 330 335GAG ACT AAA AAC GCT AAA CTT CAA GGC ACT AAA GCA GGG CAT TTG AGC 1114Glu Thr Lys Asn Ala Lys Leu Gln Gly Thr Lys Ala Gly His Leu Ser
340 345 350TAT TTA GGG GAT TGT GAG ATA GGG AAA AAC ACA AAT GTA GGG GCT GGC 1162Tyr Leu Gly Asp Cys Glu Ile Gly Lys Asn Thr Asn Val Gly Ala Gly
355 360 365GTG ATC ACT TGC AAT TAC GAT GGT AAA AAG AAA CAC CAA ACA ATC ATC 1210Val Ile Thr Cys Asn Tyr Asp Gly Lys Lys Lys His Gln Thr Ile Ile370 375 380 385GGT GAA AAT GTC TTT ATA GGG AGC GAT AGC CAG CTA GTC GCC CCC ATA 1258Gly Glu Asn Val Phe Ile Gly Ser Asp Ser Gln Leu Val Ala Pro Ile
390 395400AAT ATC GGC TCT AAT GTC TTA ATC GGC AGC GGC ACC ACT ATC ACT AAA 1306Asn Ile Gly Ser Asn Val Leu Ile Gly Ser Gly Thr Thr Ile Thr Lys
405 410 415GAC ATT CCT AGC GGT TCG TTG AGC CTT TCA CGC GCC CCT CAA ACC AAC 1354Asp Ile Pro Ser Gly Ser Leu Ser Leu Ser Arg Ala Pro Gln Thr Asn
420 425 430ATT GAA AAC GGG TAT TTT AAG TTT TTT AAG AAA CCT TAATTTGTTT GAATAA 1406Ile Glu Asn Gly Tyr Phe Lys Phe Phe Lys Lys Pro
435 440 445TGAAAAATCC TAAAAATATTA ATCATTTACT TTAA 1440
(2) Sequence 274 data:
(i) sequence characteristics:
(A) length: 445 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 274: met Leu Lys Phe Pro Lys Met Ser Leu Arg Ile Leu Met Leu Ser Val 151015 Ile Ile Leu Ala Ala Gly Lys Gly Thr Arg Met Arg Ser Ser Leu Pro
20 25 30Lys Thr Leu His Thr Ile Cys Gly Glu Pro Met Leu Phe Tyr Ile Leu
35 40 45Glu Thr Ala Phe Ser Ile Ser Asp Asp Val His Leu Ile Leu His His
50 55 60Gln Gln Glu Arg Ile Lys Glu Ala Val Leu Glu Arg Phe Lys Gly Val65 70 75 80Ile Phe His Thr Gln Ile Val Glu Lys Tyr Ser Gly Thr Gly Gly Ala
85 90 95Ile Met Gln Lys Asp Lys Thr Pro Ile Ser Thr Lys His Glu Arg Val
100 105 110Leu Ile Leu Asn Ala Asp Met Pro Leu Ile Thr Lys Asp Ala Leu Ala
115 120 125Pro Leu Leu Glu Ser Lys Asn Asn Ala Ile Gly Leu Leu His Leu Ala
130 135 140Asp Pro Lys Gly Tyr Gly Arg Val Val Leu Glu Asn His Gln Val Lys145 150 155 160Lys Ile Val Glu Glu Lys Asp Ala Asn Asp Glu Glu Lys Glu Ile Lys
165 170 175Ser Val Asn Ala Gly Val Tyr Gly Phe Glu Arg Asp Phe Leu Glu Lys
180 185 190Tyr Leu Pro Lys Leu His Asp Gln Asn Ala Gln Lys Glu Tyr Tyr Leu
195 200 205Thr Asp Leu Ile Ala Leu Gly Ile Asn Glu Asn Glu Thr Ile Asp Ala
210 215 220Ile Phe Leu Lys Glu Glu Cys Phe Leu Gly Val Asn Ser Gln Thr Glu225 230 235 240Arg Ala Lys Ala Glu Glu Ile Met Leu Glu Arg Leu Arg Lys Asn Ala
245 250 255Met Asp Leu Gly Val Val Met Gln Leu Pro Asn Ser Ile Tyr Leu Glu
260 265 270Lys Gly Val Ser Phe Lys Gly Glu Cys Val Leu Glu Gln Gly Val Arg
275 280 285Leu Ile Gly Asn Cys Leu Ile Glu Asn Ala His Ile Lys Ala Tyr Ser
290 295 300Val Ile Glu Glu Ser Gln Ile Val Asn Ser Ser Val Gly Pro PheAla305 310 315 320His Ala Arg Pro Lys Ser Val Ile Cys Asn Ser His Val Gly Asn Phe
325 330 335Val Glu Thr Lys Asn Ala Lys Leu Gln Gly Thr Lys Ala Gly His Leu
340 345 350Ser Tyr Leu Gly Asp Cys Glu Ile Gly Lys Asn Thr Asn Val Gly Ala
355 360 365Gly Val Ile Thr Cys Asn Tyr Asp Gly Lys Lys Lys His Gln Thr Ile
370 375 380Ile Gly Glu Asn Val Phe Ile Gly Ser Asp Ser Gln Leu Val Ala Pro385 390 395 400Ile Asn Ile Gly Ser Asn Val Leu Ile Gly Ser Gly Thr Thr Ile Thr
405 410 415Lys Asp Ile Pro Ser Gly Ser Leu Ser Leu Ser Arg Ala Pro Gln Thr
420 425 430Asn Ile Glu Asn Gly Tyr Phe Lys Phe Phe Lys Lys Pro
435 440 445
(2) Sequence 275 data:
(i) sequence characteristics:
(A) length: 771bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 227...715
(D) Other information:
(xi) Description of the sequence: sequence 275: GCAAAGATAA AAAACAAACG GGTTTTGGTG AAATTTTCTG GGGAAGCGTT AGCTGGNGGA 60CAACCAGTTT GGGATTGACA TTCATGTGTT AGATCACATC GCTAAAGAGA TCAAAAGTTT 120AGTGGAAAAC GATATTGAAG TGGGTATTGT GATTGGTGGA GGCAATATTA TTAGGGGGGT 180TAGCGCGGCT CAAGGGGGGA TTATTAGGCG CACCAGTGGG GATTAT ATG GGC ATG 235
Met Gly Met
1TTA GCC ACC GTG ATT AAT GCG GTA GCG ATG CAA GAA GCT TTA GAG CAT 283Leu Ala Thr Val Ile Asn Ala Val Ala Met Gln Glu Ala Leu Glu His
5 10 15ATC GGC TTA GAC ACA AGG GTG CAG AGC GCG ATT GAA ATC AAA GAG ATT 331Ile Gly Leu Asp Thr Arg Val Gln Ser Ala Ile Glu Ile Lys Glu Ile20 25 30 35TGT GAA AGT TAC ATT TAC AGA AAA GCG ATC AGG CAT TTA GAA AAG GGT 379Cys Glu Ser Tyr Ile Tyr Arg Lys Ala Ile Arg His Leu Glu Lys Gly
40 45 50AGG GTG GTG ATT TTT GGC GCA GGC ACG GGA AAC CCG TTT TTC ACT ACG 427Arg Val Val Ile Phe Gly Ala Gly Thr Gly Asn Pro Phe Phe Thr Thr
55 60 65GAT ACG GCT GCC ACT TTA AGA GCG ATT GAA ATT GGA TCG GAT TTA ATC 475Asp Thr Ala Ala Thr Leu Arg Ala Ile Glu Ile Gly Ser Asp Leu Ile
70 75 80ATT AAA GCG ACT AAA GTG GAT GGC ATT TAC GAC AAA GAT CCT AAC AAG 523Ile Lys Ala Thr Lys Val Asp Gly Ile Tyr Asp Lys Asp Pro Asn Lys
85 90 95TTT AAA GAC GCT AAA AAA TTA GAC ACT TTA AGC TAT AAC GAT GCC TTG 571Phe Lys Asp Ala Lys Lys Leu Asp Thr Leu Ser Tyr Asn Asp Ala Leu100 105 110 115ATA GGG GAT ATT GAA GTG ATG GAC GAT ACC GCT ATT TCT TTA GCT AAA 619Ile Gly Asp Ile Glu Val Met Asp Asp Thr Ala Ile Ser Leu Ala Lys
120 125 130GAC AAT AAG CTC CCC ATT GTG GTG TGT AAC ATG TTC AAA AAA GGG AAT 667Asp Asn Lys Leu Pro Ile Val Val Cys Asn Met Phe Lys Lys Gly Asn
135 140 145TTA TTG CAA GTG ATC AAG CAC CAA CAA GGC GTA TTT TCT ATG GTA AAA T 716Leu Leu Gln Val Ile Lys His Gln Gln Gly Val Phe Ser Met Val Lys
150 155 160AAGCCCTTTA ACATTGGATA GAACTCAAAA TAAAAGGATC AGTTTGAAAA AAGAG 771
(2) Sequence 276 data:
(i) sequence characteristics:
(A) length: 163 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 276: met Gly Met Leu Ala Thr Val Ile Asn Ala Val Ala Met Gln Glu Ala 151015 Leu Glu His Ile Gly Leu Asp Thr Arg Val Gln Ser Ala Ile Glu Ile
20 25 30Lys Glu Ile Cys Glu Ser Tyr Ile Tyr Arg Lys Ala Ile Arg His Leu
35 40 45Glu Lys Gly Arg Val Val Ile Phe Gly Ala Gly Thr Gly Asn Pro Phe
50 55 60Phe Thr Thr Asp Thr Ala Ala Thr Leu Arg Ala Ile Glu Ile Gly Ser65 70 75 80Asp Leu Ile Ile Lys Ala Thr Lys Val Asp Gly Ile Tyr Asp Lys Asp
85 90 95Pro Asn Lys Phe Lys Asp Ala Lys Lys Leu Asp Thr Leu Ser Tyr Asn
100 105 110Asp Ala Leu Ile Gly Asp Ile Glu Val Met Asp Asp Thr Ala Ile Ser
115 120 125Leu Ala Lys Asp Asn Lys Leu Pro Ile Val Val Cys Asn Met Phe Lys
130 135 140Lys Gly Asn Leu Leu Gln Val Ile Lys His Gln Gln Gly Val Phe Ser145 150 155 160Met Val Lys
(2) Sequence 277 data:
(i) sequence characteristics:
(A) length: 659bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 56...607
(D) Other information:
(xi) Description of the sequence: sequence 277: TCATGTAAAA TAAAGGGTTT TATTAAAGAT GAGAGATTGT TTTAAGGTTT GAATA ATG 58
Met
1AGA GCT TTT TTA AAG ATT TTA ATG GTT TTG ATT TTT ATG AGC GTT GCT 106Arg Ala Phe Leu Lys Ile Leu Met Val Leu Ile Phe Met Ser Val Ala
5 10 15TAT GCT AAA AAT CCT TCA ACG CTT TCT AAA GAA GAA GAG GTT TTG CAG 154Tyr Ala Lys Asn Pro Ser Thr Leu Ser Lys Glu Glu Glu Val Leu Gln
20 25 30CAT TTG CAA AGT TTT AGC GCG CAT TTC AAG CAGGTT TTA AAA AAT GAA 202His Leu Gln Ser Phe Ser Ala His Phe Lys Gln Val Leu Lys Asn Glu
35 40 45AAA CCT TTA GTT TAT TAC GGG GTT TTA AAG GCT AAA GCC CCT AAT TGG 250Lys Pro Leu Val Tyr Tyr Gly Val Leu Lys Ala Lys Ala Pro Asn Trp50 55 60 65GCT TTA TGG GTT TAT GAA AAG CCT TTA AAA AAA GAA ATT TAC ATG AAC 298Ala Leu Trp Val Tyr Glu Lys Pro Leu Lys Lys Glu Ile Tyr Met Asn
70 75 80GAT AAA GAA GTG GTA ATT TAT GAG CCT AAT TTG TTT CAA GCG ACC ATC 346Asp Lys Glu Val Val Ile Tyr Glu Pro Asn Leu Phe Gln Ala Thr Ile
85 90 95ACG CCC TTA AAA GAC AAG ACG GAT TTT TTC ACC ATT CTC AAG CGT TTA 394Thr Pro Leu Lys Asp Lys Thr Asp Phe Phe Thr Ile Leu Lys Arg Leu
100 105 110AAA AAG CAA GAT GAC GGA TCT TTT AAA ACG ACT ATC AAC AAA ACC ACT 442Lys Lys Gln Asp Asp Gly Ser Phe Lys Thr Thr Ile Asn Lys Thr Thr
115 120 125TAT CGT TTG GTT TTT AAA GAC GGC AAG CCT TTT TCA TTG GAA TTT AAA 490Tyr Arg Leu Val Phe Lys Asp Gly Lys Pro Phe Ser Leu Glu Phe Lys130 135 140 145GAT GGA ATG AAC AAT CTT GTA ACG ATC ACT TTT TCT CAA GCA GAA ATC 538Asp Gly Met Asn Asn Leu Val Thr Ile Thr Phe Ser Gln Ala Glu Ile
150 155 160AAC CCC ACC ATT GCT AAT GAA ATC TTT GTT TTT AAG CCT AAA GAT GAA 586Asn Pro Thr Ile Ala Asn Glu Ile Phe Val Phe Lys Pro Lys Asp Glu
165 170 175AAC ATT GAT ATT GTG CGC CAA TGATTTTTAA TGATTCATTG CATCTTGTTA GCAA 641Asn Ile Asp Ile Val Arg Gln
180AAGTTAGCTA AAATAGAC 659
(2) Sequence 278 data:
(i) sequence characteristics:
(A) length: 184 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 278: met Arg Ala Phe Leu Lys Ile Leu Met Val Leu Ile Phe Met Ser Val 151015 Ala Tyr Ala Lys Asn Pro Ser Thr Leu Ser Lys Glu Glu Glu Val Leu
20 25 30Gln His Leu Gln Ser Phe Ser Ala His Phe Lys Gln Val Leu Lys Asn
35 40 45Glu Lys Pro Leu Val Tyr Tyr Gly Val Leu Lys Ala Lys Ala Pro Asn
50 55 60Trp Ala Leu Trp Val Tyr Glu Lys Pro Leu Lys Lys Glu Ile Tyr Met65 70 75 80Asn Asp Lys Glu Val Val Ile Tyr Glu Pro Asn Leu Phe Gln Ala Thr
85 90 95Ile Thr Pro Leu Lys Asp Lys Thr Asp Phe Phe Thr Ile Leu Lys Arg
100 105 110Leu Lys Lys Gln Asp Asp Gly Ser Phe Lys Thr Thr Ile Asn Lys Thr
115 120 125Thr Tyr Arg Leu Val Phe Lys Asp Gly Lys Pro Phe Ser Leu Glu Phe
130 135 140Lys Asp Gly Met Asn Asn Leu Val Thr Ile Thr Phe Ser Gln Ala Glu145 150 155 160Ile Asn Pro ThrIle Ala Asn Glu Ile Phe Val Phe Lys Pro Lys Asp
165 170 175Glu Asn Ile Asp Ile Val Arg Gln
180
(2) Material of seq id No. 279:
(i) sequence characteristics:
(A) length: 3035bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 729...2981
(D) Other information:
(xi) Description of the sequence: sequence 279: GAAACGATCG CAGAAAGCAA TGAAAGCACG GTAGTAGCGG AATTTCATAG CAGTAATGAA 60AAAAAAGCGC TTATGAGAGC GAAGCAGAGC TAGAAAGGGC GTTTATTAAG CTTTTAGAAA 120AACAAGGCTA TGAATTTAAA AAAATCCACA AAGAAGAAGA ATTAAAAGAC AATTTAAAAG 180AGCAGTTAGA AAAGCTTAAT GATCATTCTT TCACGCCTAA AGAATGGGAC ACTCTTTATT 240CTCAATTCAT CGCTAATAAA AACGATGACT ATAAGGCTAA AACGAAAAAG ATCCAAGAAG 300ATCCGATTTT TAATCTCACG CTAGAGAACG GGAAAACCAA AAACATTAAA ATCATTGATA 360AGAAAAATAT CCATAGAAAC GCCTTGCAAG TGATCCACCA ATACAGCAAT AAAGGGGGGA 420AGTATCAAAA CCGCTATGAT GTGAGTATCC TTGTGAATGG CTTGCCTTTA GTGCATGTGG 480AATTGAAAAA AAGAGGCGTG GCGATCAGGG AGGCGTTCAA CCAGATCAAG CGCTATAAAA 540GGGATAGTTT TAGCGCTGAA GACGGGCTTT TTGATTTTGT GCAGATTTTT GTCATCAGTA 600ACGGCACGAG CTCTAAATAC TATTCAAACA CCACAAGAAT AGCCCAGCTG GAAAAAAACC 660ATAAAGCCGA TACTTTTGAA TTCACGAATT ATTGGGCGGA TAGCAAGAAT CACAATATTG 720AGGATTTA ATG GAT TTT GCT AAG GCG TTT TTT GCA AAG CGC AGC CTT TTG 770
Met Asp Phe Ala Lys Ala Phe Phe Ala Lys Arg Ser Leu Leu
1 5 10AAC GTT TTA ACG TGC TAT TGC GTT TTC ACA AGC GAA GAG GTT TTA TTG 818Asn Val Leu Thr Cys Tyr Cys Val Phe Thr Ser Glu Glu Val Leu Leu15 20 25 30GTG ATG CGG CCT TAT CAA ATC GTG GCG GCC GAA AGG ATT TTG GAA AAG 866Val Met Arg Pro Tyr Gln Ile Val Ala Ala Glu Arg Ile Leu Glu Lys
35 40 45ATC AAA ACC GCG CAA AAT AGT AAA ACG AAA AAT CAA AGC AAA GGC TAT 914Ile Lys Thr Ala Gln Asn Ser Lys Thr Lys Asn Gln Ser Lys Gly Tyr
50 55 60ATC TGG CAC ACG ACA GGG AGC GGT AAA ACC CTA ACG AGC TTT AAA AGC 962Ile Trp His Thr Thr Gly Ser Gly Lys Thr Leu Thr Ser Phe Lys Ser
65 70 75GCA ACG TTG GCT AAA GAA TTA GAG AGC GTT TCA AAA GTC TTG TTC GTG 1010Ala Thr Leu Ala Lys Glu Leu Glu Ser Val Ser Lys Val Leu Phe Val
80 85 90GTG GAC AGG AAG GAT TTG GAC TAT CAA ACC ATG AAA GAA TAC GAT AAA 1058Val Asp Arg Lys Asp Leu Asp Tyr Gln Thr Met Lys Glu Tyr Asp Lys95 100 105 110TTC CAA AAA GAT TGC GCT AAT TCC AAC ACA AGC ACT AAG ATT TTA AAA 1106Phe Gln Lys Asp Cys Ala Asn Ser Asn Thr Ser Thr Lys Ile Leu Lys
115 120 125GAA CAG CTT GAA GAT TCT AAC GCT AAA ATC ATT ATC ACC ACG ATC CAA 1154Glu Gln Leu Glu Asp Ser Asn Ala Lys Ile Ile Ile Thr Thr Ile Gln
130 135 140AAA TTA GAC AAA TTC GTT AAA TCC CAT AAA GGG CAT GCG ATT TTT AAT 1202Lys Leu Asp Lys Phe Val Lys Ser His Lys Gly His Ala Ile Phe Asn
145 150 155GAA GAA GTT GTG ATG ATT TTT GAT GAA TGC CAC AGG AGT CAG TTA GGC 1250Glu Glu Val Val Met Ile Phe Asp Glu Cys His Arg Ser Gln Leu Gly
160 165 170TCT ATG CAT CAA GCC ATC ACT AAA GCG TTT AAA AAA TAC CAC CTT TTT 1298Ser Met His Gln Ala Ile Thr Lys Ala Phe Lys Lys Tyr His Leu Phe175 180 185 190GGC TTT ACT GGC ACG CCC ATT TTT GCA GCT AAT TGC GAT AAA AAC AAC 1346Gly Phe Thr Gly Thr Pro Ile Phe Ala Ala Asn Cys Asp Lys Asn Asn
195 200 205CCT TTA GGC ACG ACA GAG CAA AAG TTT GGG AAA TGC CTC CAC CAA TAC 1394Pro Leu Gly Thr Thr Glu Gln Lys Phe Gly Lys Cys Leu His Gln Tyr
210 215 220ACC ATT ATT GAT GCG ATC AGG GAT AAA AAC GTT TTG CCC TTT AGA GTG 1442Thr Ile Ile Asp Ala Ile Arg Asp Lys Asn Val Leu Pro Phe Arg Val
225 230 235GAA TAC CAC AAC ACC ATT AAA GCT AAA GAG GAC ATT AAG GAT AAT AAG 1490Glu Tyr His Asn Thr Ile Lys Ala Lys Glu Asp Ile Lys Asp Asn Lys
240 245 250GTT AGA GCG GTT GAT GAA AAA AAC GCC CTT TTG GAT ACT AGG AGG ATC 1538Val Arg Ala Val Asp Glu Lys Asn Ala Leu Leu Asp Thr Arg Arg Ile255 260 265 270AAA GAA ATC ACT AAA TGC ATT TTA GAG CGT TTC AAT CAA GCC ACT AAA 1586Lys Glu Ile Thr Lys Cys Ile Leu Glu Arg Phe Asn Gln Ala Thr Lys
275 280 285AAT AAA AAA TTC AAT TCC ATT CTG GCA TGC TCT AGC ATA GAA GCG CTG 1634Asn Lys Lys Phe Asn Ser Ile Leu Ala Cys Ser Ser Ile Glu Ala Leu
290 295 300AAA AAA TAC TAC CAA GCC TTT AAA GAA GAA AAA CAC GAT CTT AAA ATC 1682Lys Lys Tyr Tyr Gln Ala Phe Lys Glu Glu Lys His Asp Leu Lys Ile
305 310 315GCT GCC ATT TTT AGC TAT AGC GCT AAT GAG GAA ATT GAC ACG CTA GAA 1730Ala Ala Ile Phe Ser Tyr Ser Ala Asn Glu Glu Ile Asp Thr Leu Glu
320 325 330GAT GAA AAC AAT GAA AGC GCT TGC CGG CTA GAC AAA AGC TCA AGG GAT 1778Asp Glu Asn Asn Glu Ser Ala Cys Arg Leu Asp Lys Ser Ser Arg Asp335 340 345 350TTT TTA GAG GGC GCG ATT GCG GAT TAT AAT GGG ATG TTT GGC GTT TCT 1826Phe Leu Glu Gly Ala Ile Ala Asp Tyr Asn Gly Met Phe Gly Val Ser
355 360 365TTT GAC ACT TCG GAT CAA AAA TTC CAA AGT TAT TAC AAG GAT CTT TCT 1874Phe Asp Thr Ser Asp Gln Lys Phe Gln Ser Tyr Tyr Lys Asp Leu Ser
370 375 380CAA AAA ATG AAA GAG CGT AAA ATC GAT CTT TTA ATG GTG GTG AAC ATG 1922Gln Lys Met Lys Glu Arg Lys Ile Asp Leu Leu Met Val Val Asn Met
385 390 395TTT TTG ACC GGG TTT GAC GCT ACA AGG CTC AAC ACC CTT TGG GTG GAT 1970Phe Leu Thr Gly Phe Asp Ala Thr Arg Leu Asn Thr Leu Trp Val Asp
400 405 410AAA AAT CTC AAA TAC CAT GGG CTA ATT CAA GCT TTT TCA CGC GCA AAC 2018Lys Asn Leu Lys Tyr His Gly Leu Ile Gln Ala Phe Ser Arg Ala Asn415 420 425 430CGC ATT TTA GAT AGC GTT AAA ACG CAT GGG AAT ATC GTG TGT TTT AGG 2066Arg Ile Leu Asp Ser Val Lys Thr His Gly Asn Ile Val Cys Phe Arg
435 440 445GAT TTA GAA CAG GAT TTG AAT GAC GCT CTC ATG CTT TTT GGC AAC AAG 2114Asp Leu Glu Gln Asp Leu Asn Asp Ala Leu Met Leu Phe Gly Asn Lys
450 455 460GAC GCT CAA TCT ATT GCG CTG TTA AGA AAA TAT GAA GAT TAT TTG AAA 2162Asp Ala Gln Ser Ile Ala Leu Leu Arg Lys Tyr Glu Asp Tyr Leu Lys
465 470 475GGC TAC ACG GAT AAC AAC AAA GAA TAC GAG GGC TAT GAG GGT TTG ATT 2210Gly Tyr Thr Asp Asn Asn Lys Glu Tyr Glu Gly Tyr Glu Gly Leu Ile
480 485 490AAA AGG CTT TTA ACC GAA TTC CCA TTA AAA GAG CCA ATC GTT TCA GAA 2258Lys Arg Leu Leu Thr Glu Phe Pro Leu Lys Glu Pro Ile Val Ser Glu495 500 505 510AGC CAG AAA AAG GAT TTT ATT AAG CTT TTT GGC AAG ATT TTG AAA TTA 2306Ser Gln Lys Lys Asp Phe Ile Lys Leu Phe Gly Lys Ile Leu Lys Leu
515 520 525GAA AAT ATT TTA AAC AGC TTT GAA AAT TTC AAA AAA GAC GAT TAC ATC 2354Glu Asn Ile Leu Asn Ser Phe Glu Asn Phe Lys Lys Asp Asp Tyr Ile
530 535 540AAT CCC AGG GAT TTT CAA GAC TAT CAA AGC AAA TAC CTT GAT TTT TAC 2402Asn Pro Arg Asp Phe Gln Asp Tyr Gln Ser Lys Tyr Leu Asp Phe Tyr
545 550 555GAT GCA ATG AGA TCA GAA AAA GGG AAG GAT AAA GAA GAG ATT AAT GAT 2450Asp Ala Met Arg Ser Glu Lys Gly Lys Asp Lys Glu Glu Ile Asn Asp
560 565 570GAT TTG ATT TTT GAA ATT GAA CTC ATC AAA CAA GTG GAA GTC AAT ATT 2498Asp Leu Ile Phe Glu Ile Glu Leu Ile Lys Gln Val Glu Val Asn Ile575 580 585 590GAC TAT ATT TTG AAT TTG ATT GAA GAG TTC GCT AAA GAG CAT GGG GTG 2546Asp Tyr Ile Leu Asn Leu Ile Glu Glu Phe Ala Lys Glu His Gly Val
595 600 605GAA ATC CAA GGC GTT AAA ACC AAA ATA GAG CCA ATC ATC AAC TCC AGC 2594Glu Ile Gln Gly Val Lys Thr Lys Ile Glu Pro Ile Ile Asn Ser Ser
610 615 620ATA GAG TTA AGG AAT AAA AAA GAT TTG ATC ATG GAT TTC ATT GAC AAA 2642Ile Glu Leu Arg Asn Lys Lys Asp Leu Ile Met Asp Phe Ile Asp Lys
625 630 635TAC AAC AAA GAC CAA GAA GTC CAT GCG CAT TTT CAA GAT TAT ATC CAC 2690Tyr Asn Lys Asp Gln Glu Val His Ala His Phe Gln Asp Tyr Ile His
640 645 650CAA AAA AGA GAA GAG GAA TTC CAA AAT ATC ATA GAA GAA AAC CGC TTG 2738Gln Lys Arg Glu Glu Glu Phe Gln Asn Ile Ile Glu Glu Asn Arg Leu655 660 665 670AAT GAA GAA AAA GCC TAT TCG TTC ATG CAG CAT GCC TTT AAA GGG GGC 2786Asn Glu Glu Lys Ala Tyr Ser Phe Met Gln His Ala Phe Lys Gly Gly
675 680 685GAA ATC AGT TTT AGT GGG ACG GAA TTC CCT AAA ATC ATT GAA GAA AAA 2834Glu Ile Ser Phe Ser Gly Thr Glu Phe Pro Lys Ile Ile Glu Glu Lys
690 695 700CCC TCC ATG TTT GGT AAA AAT TCG CGC TAT CAA GAG GTG AAA GAA AAA 2882Pro Ser Met Phe Gly Lys Asn Ser Arg Tyr Gln Glu Val Lys Glu Lys
705 710 715GTC GCT GCA AGC CTT TCT CGT TTT TTC CAC CGC TTT TGT GAT CTC ACT 2930Val Ala Ala Ser Leu Ser Arg Phe Phe His Arg Phe Cys Asp Leu Thr
720 725 730AGC GCT ATA TTT AAG AAA AAT GAG GTT AAA AAA GAT GAG GTT AAT GAA 2978Ser Ala Ile Phe Lys Lys Asn Glu Val Lys Lys Asp Glu Val Asn Glu735 740 745 750AAA TAGTTCATGA ACGCTTTTGC ATTAAGGCTC AAAAAAAGCG CCGTTTAATG GATT 3035Lys
(2) Sequence 280 data:
(i) sequence characteristics:
(A) length: 751 amino acid
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 280: met Asp Phe Ala Lys Ala Phe Phe Ala Lys Arg Ser Leu Leu Asn Val 151015 Leu Thr Cys Tyr Cys Val Phe Thr Ser Glu Glu Val Leu Leu Val Met
20 25 30Arg Pro Tyr Gln Ile Val Ala Ala Glu Arg Ile Leu Glu Lys Ile Lys
35 40 45Thr Ala Gln Asn Ser Lys Thr Lys Asn Gln Ser Lys Gly Tyr Ile Trp
50 55 60His Thr Thr Gly Ser Gly Lys Thr Leu Thr Ser Phe Lys Ser Ala Thr65 70 75 80Leu Ala Lys Glu Leu Glu Ser Val Ser Lys Val Leu Phe Val Val Asp
85 90 95Arg Lys Asp Leu Asp Tyr Gln Thr Met Lys Glu Tyr Asp Lys Phe Gln
100 105 110Lys Asp Cys Ala Asn Ser Asn Thr Ser Thr Lys Ile Leu Lys Glu Gln
115 120 125Leu Glu Asp Ser Asn Ala Lys Ile Ile Ile Thr Thr Ile Gln Lys Leu
130 135 140Asp Lys Phe Val Lys Ser His Lys Gly His Ala Ile Phe Asn Glu Glu145 150 155 160Val Val Met Ile Phe Asp Glu Cys His Arg Ser Gln Leu Gly Ser Met
165 170 175His Gln Ala Ile Thr Lys Ala Phe Lys Lys Tyr His Leu Phe Gly Phe
180 185 190Thr Gly Thr Pro Ile Phe Ala Ala Asn Cys Asp Lys Asn Asn Pro Leu
195 200 205Gly Thr Thr Glu Gln Lys Phe Gly Lys Cys Leu His Gln Tyr Thr Ile
210 215 220Ile Asp Ala Ile Arg Asp Lys Asn Val Leu Pro Phe Arg Val Glu Tyr225 230 235 240His Asn Thr Ile Lys Ala Lys Glu Asp Ile Lys Asp Asn Lys Val Arg
245 250 255Ala Val Asp Glu Lys Asn Ala Leu Leu Asp Thr Arg Arg Ile Lys Glu
260 265 270Ile Thr Lys Cys Ile Leu Glu Arg Phe Asn Gln Ala Thr Lys Asn Lys
275 280 285Lys Phe Asn Ser Ile Leu Ala Cys Ser Ser Ile Glu Ala Leu Lys Lys
290 295 300Tyr Tyr Gln Ala Phe Lys Glu Glu Lys His Asp Leu Lys Ile Ala Ala305 310 315 320Ile Phe Ser Tyr Ser Ala Asn Glu Glu Ile Asp Thr Leu Glu Asp Glu
325 330 335Asn Asn Glu Ser Ala Cys Arg Leu Asp Lys Ser Ser Arg Asp Phe Leu
340 345 350Glu Gly Ala Ile Ala Asp Tyr Asn Gly Met Phe Gly Val Ser Phe Asp
355 360 365Thr Ser Asp Gln Lys Phe Gln Ser Tyr Tyr Lys Asp Leu Ser Gln Lys
370 375 380Met Lys Glu Arg Lys Ile Asp Leu Leu Met Val Val Asn Met Phe Leu385 390 395 400Thr Gly Phe Asp Ala Thr Arg Leu Asn Thr Leu Trp Val Asp Lys Asn
405 410 415Leu Lys Tyr His Gly Leu Ile Gln Ala Phe Ser Arg Ala Asn Arg Ile
420 425 430Leu Asp Ser Val Lys Thr His Gly Asn Ile Val Cys Phe Arg Asp Leu
435 440 445Glu Gln Asp Leu Asn Asp Ala Leu Met Leu Phe Gly Asn Lys Asp Ala
450 455 460Gln Ser Ile Ala Leu Leu Arg Lys Tyr Glu Asp Tyr Leu Lys Gly Tyr465 470 475 480Thr Asp Asn Asn Lys Glu Tyr Glu Gly Tyr Glu Gly Leu Ile Lys Arg
485 490 495Leu Leu Thr Glu Phe Pro Leu Lys Glu Pro Ile Val Ser Glu Ser Gln
500 505 510Lys Lys Asp Phe Ile Lys Leu Phe Gly Lys Ile Leu Lys Leu Glu Asn
515 520 525Ile Leu Asn Ser Phe Glu Asn Phe Lys Lys Asp Asp Tyr Ile Asn Pro
530 535 540Arg Asp Phe Gln Asp Tyr Gln Ser Lys Tyr Leu Asp Phe Tyr Asp Ala545 550 555 560Met Arg Ser Glu Lys Gly Lys Asp Lys Glu Glu Ile Asn Asp Asp Leu
565 570 575Ile Phe Glu Ile Glu Leu Ile Lys Gln Val Glu Val Asn Ile Asp Tyr
580 585 590Ile Leu Asn Leu Ile Glu Glu Phe Ala Lys Glu His Gly Val Glu Ile
595 600 605Gln Gly Val Lys Thr Lys Ile Glu Pro Ile Ile Asn Ser Ser Ile Glu
610 615 620Leu Arg Asn Lys Lys Asp Leu Ile Met Asp Phe Ile Asp Lys Tyr Asn625 630 635 640Lys Asp Gln Glu Val His Ala His Phe Gln Asp Tyr Ile His Gln Lys
645 650 655Arg Glu Glu Glu Phe Gln Asn Ile Ile Glu Glu Asn Arg Leu Asn Glu
660 665 670Glu Lys Ala Tyr Ser Phe Met Gln His Ala Phe Lys Gly Gly Glu Ile
675 680 685Ser Phe Ser Gly Thr Glu Phe Pro Lys Ile Ile Glu Glu Lys Pro Ser
690 695 700Met Phe Gly Lys Asn Ser Arg Tyr Gln Glu Val Lys Glu Lys Val Ala705 710 715 720Ala Ser Leu Ser Arg Phe Phe His Arg Phe Cys Asp Leu Thr Ser Ala
725 730 735Ile Phe Lys Lys Asn Glu Val Lys Lys Asp Glu Val Asn Glu Lys
740 745 750
(2) Sequence 281 data:
(i) sequence characteristics:
(A) length: 850bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 68...799
(D) Other information:
(xi) Description of the sequence: sequence 281: ACCACTATTG TAGAAAAATA ACAAGAGGGT TTGCAAAAAC TCTCATTAAA AACAAGGAGC 60AAAAAAG ATG AAA AAG GCG GGC TTT CTT TTT TTA GCG GTA ATG GCT ATC 109
Met Lys Lys Ala Gly Phe Leu Phe Leu Ala Val Met Ala Ile
1 5 10GTT GTT ATG AGT TTA AAC GCT AAA GAT CCG AAT GTG TTG CGT AAG ATT 157Val Val Met Ser Leu Asn Ala Lys Asp Pro Asn Val Leu Arg Lys Ile15 20 25 30GTT TTT GAG AAA TGT CTG CCT AAT TAT GAG AAA AAT CAG AAT CCT TCG 205Val Phe Glu Lys Cys Leu Pro Asn Tyr Glu Lys Asn Gln Asn Pro Ser
35 40 45CCA TGC ATA GAA GTC AAA CCC GAT GCC GGC TAT GTG GTT TTA AAA GAT 253Pro Cys Ile Glu Val Lys Pro Asp Ala Gly Tyr Val Val Leu Lys Asp
50 55 60ATT AAC GGC CCG TTG CAA TAT TTG TTG ATG CCA ACA ACT CAC ATT AGC 301Ile Asn Gly Pro Leu Gln Tyr Leu Leu Met Pro Thr Thr His Ile Ser
65 70 75GGT ATT GAA AGC CCT TTG TTA CTT GAT CCT TCT ACG CCT AAC TTT TTT 349Gly Ile Glu Ser Pro Leu Leu Leu Asp Pro Ser Thr Pro Asn Phe Phe
80 85 90TAT TTA TCC TGG CAA GCG CGT GAT TTT ATG AGT AAA AAA TAC GGC CAA 397Tyr Leu Ser Trp Gln Ala Arg Asp Phe Met Ser Lys Lys Tyr Gly Gln95 100 105 110CCC ATT CCT GAT TAT GCG ATT TCT TTG ACG ATT AAC TCT AGC AAA GGG 445Pro Ile Pro Asp Tyr Ala Ile Ser Leu Thr Ile Asn Ser Ser Lys Gly
115 120 125CGA TCG CAA AAC CAT TTT CAT ATC CAT ATC TCT TGC ATT AGT CTT GAA 493Arg Ser Gln Asn His Phe His Ile His Ile Ser Cys Ile Ser Leu Glu
130 135 140GCA CGC AAA CAG CTG GAT AAT AAC CTA AAA AAA ATC AAC AGC CGT TGG 541Ala Arg Lys Gln Leu Asp Asn Asn Leu Lys Lys Ile Asn Ser Arg Trp
145 150 155TCG CCA TTA CCG GGC GGT TTG AATGGG CAT AAA TAC TTG GCG CGT CGG 589Ser Pro Leu Pro Gly Gly Leu Asn Gly His Lys Tyr Leu Ala Arg Arg
160 165 170GTA ACA GAG AGC GAG TTA GTG CAA AAA AGC CCG TTT GTC ATG CTT AAT 637Val Thr Glu Ser Glu Leu Val Gln Lys Ser Pro Phe Val Met Leu Asn175 180 185 190AAA GAA GTG CCT AAT GCG TAC AAA CGC ATG GGG GAC TAT GGC TTA GCG 685Lys Glu Val Pro Asn Ala Tyr Lys Arg Met Gly Asp Tyr Gly Leu Ala
195 200 205GTG GTG CAA CAA AGC GAT AAC TCC TTT GTC TTA TTA GCG ACA CAA TTT 733Val Val Gln Gln Ser Asp Asn Ser Phe Val Leu Leu Ala Thr Gln Phe
210 215 220AAC CCA TTG ACT TTA AAT CGC GCT TCA GCC GAA GAG ATT CAA GAT CAT 781Asn Pro Leu Thr Leu Asn Arg Ala Ser Ala Glu Glu Ile Gln Asp His
225 230 235GAA TGC GCG ATT TTG CAC TAAAGCGAGT TAGATTCTTA AGCTTGAGCG ATAACCTT 837Glu Cys Ala Ile Leu His
240TAAAAAGCGT TAT 850
(2) Sequence 282 data:
(i) sequence characteristics:
(A) length: 244 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 282: met Lys Lys Ala Gly Phe Leu Phe Leu Ala Val Met Ala Ile Val Val 151015 Met Ser Leu Asn Ala Lys Asp Pro Asn Val Leu Arg Lys Ile Val Phe
20 25 30Glu Lys Cys Leu Pro Asn Tyr Glu Lys Asn Gln Asn Pro Ser Pro Cys
35 40 45Ile Glu Val Lys Pro Asp Ala Gly Tyr Val Val Leu Lys Asp Ile Asn
50 55 60Gly Pro Leu Gln Tyr Leu Leu Met Pro Thr Thr His Ile Ser Gly Ile65 70 75 80Glu Ser Pro Leu Leu Leu Asp Pro Ser Thr Pro Asn Phe Phe Tyr Leu
85 90 95Ser Trp Gln Ala Arg Asp Phe Met Ser Lys Lys Tyr Gly Gln Pro Ile
100 105 110Pro Asp Tyr Ala Ile Ser Leu Thr Ile Asn Ser Ser Lys Gly Arg Ser
115 120 125Gln Asn His Phe His Ile His Ile Ser Cys Ile Ser Leu Glu Ala Arg
130 135 140Lys Gln Leu Asp Asn Asn Leu Lys Lys Ile Asn Ser Arg Trp Ser Pro145 150 155 160Leu Pro Gly Gly Leu Asn Gly His Lys Tyr Leu Ala Arg Arg Val Thr
165 170 175Glu Ser Glu Leu Val Gln Lys Ser Pro Phe Val Met Leu Asn Lys Glu
180 185 190Val Pro Asn Ala Tyr Lys Arg Met Gly Asp Tyr Gly Leu Ala Val Val
195 200 205Gln Gln Ser Asp Asn Ser Phe Val Leu Leu Ala Thr Gln Phe Asn Pro
210 215 220Leu Thr Leu Asn Arg Ala Ser Ala Glu Glu Ile Gln Asp His Glu Cys225 230 235 240Ala Ile Leu His
(2) Sequence 283 data:
(i) sequence characteristics:
(A) length: 981bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 57...929
(D) Other information:
(xi) Description of the sequence: sequence 283: GTCCTATTTT TTCATTCATT CAACGAATTT AAAAATTACA ATAAAGAGTT ATAGTT ATG 59
Met
1AAA CGA AGG GAT TTT ATT AAA ACG ACT ACT TTA GGC GCT ACA GGT GCT 107Lys Arg Arg Asp Phe Ile Lys Thr Thr Thr Leu Gly Ala Thr Gly Ala
5 10 15GTT TTA GGA GCA CAG ATT TTG CAG GCA GAA GAA AGT AAA GGG AGT GTT 155Val Leu Gly Ala Gln Ile Leu Gln Ala Glu Glu Ser Lys Gly Ser Val
20 25 30GCA AAA TAT AAA ATA GAA GCT CAA TAC AGC ATT GAT TTT GAT TCT GCA 203Ala Lys Tyr Lys Ile Glu Ala Gln Tyr Ser Ile Asp Phe Asp Ser Ala
35 40 45GAA CAC ACT TCA CTT TTC ATT CCC ATG CCG AGT GTT GTA GCG AGC AAT 251Glu His Thr Ser Leu Phe Ile Pro Met Pro Ser Val Val Ala Ser Asn50 55 60 65GTG CAT TTA CAA GGC AAT CAT GCT AGC TAT AAA AGC ATG CTC AAT TTT 299Val His Leu Gln Gly Asn His Ala Ser Tyr Lys Ser Met Leu Asn Phe
70 75 80GGA GTG CCT TAT TTG CAA GTG GAT TTT TTA AAA AGC ACT CAA AAAAAG 347Gly Val Pro Tyr Leu Gln Val Asp Phe Leu Lys Ser Thr Gln Lys Lys
85 90 95CAA GTC CAT TTG TCT TAT GAG ATC GCT AGC TAT CAA TTG AAT GAG CGT 395Gln Val His Leu Ser Tyr Glu Ile Ala Ser Tyr Gln Leu Asn Glu Arg
100 105 110TTG TTT GAA ACG AGC GAT TTT GTA GCA ATG GGG CGT TAT GAA AGA GAC 443Leu Phe Glu Thr Ser Asp Phe Val Ala Met Gly Arg Tyr Glu Arg Asp
115 120 125GAT GCG AGC GTG GCT AAC ATT GCC AAC CAG CTT AAG GGA ACA ACC CCT 491Asp Ala Ser Val Ala Asn Ile Ala Asn Gln Leu Lys Gly Thr Thr Pro130 135 140 145AAA GAA AGC GTT CGC AAT TTT TAT GCG TTC ATC AAG CAT GAG ATG CCT 539Lys Glu Ser Val Arg Asn Phe Tyr Ala Phe Ile Lys His Glu Met Pro
150 155 160AAG AGA CAG AAG GCT TTA GAG GGT AAA GAA AAT TTA CCT AAG CGT GAG 587Lys Arg Gln Lys Ala Leu Glu Gly Lys Glu Asn Leu Pro Lys Arg Glu
165 170 175AGT TTG CCC TGG TTT GCA ACC ATT TCA AAA GAG AGC ATG TTT GTG TCC 635Ser Leu Pro Trp Phe Ala Thr Ile Ser Lys Glu Ser Met Phe Val Ser
180 185 190TTA TGC CAT GCG TGC GGG ATT AAA AGC GCT GAA GTG CAA GGC TTG AAA 683Leu Cys His Ala Cys Gly Ile Lys Ser Ala Glu Val Gln Gly Leu Lys
195 200 205CTG GGT CAA AAC AGC GTG GTG AAA AAC GCT CCT AGA GTG GAA GTG TAT 731Leu Gly Gln Asn Ser Val Val Lys Asn Ala Pro Arg Val Glu Val Tyr210 215 220 225TTG AAA GAT TCA TTT CTA GCG TTT GAT TTT CAA AAT AAT CAC AAG GAA 779Leu Lys Asp Ser Phe Leu Ala Phe Asp Phe Gln Asn Asn His Lys Glu
230 235 240GTT TTT ATC CCG TTG AAT CGT CAT AAA GAC ATG CAG TTA GAT TCT GCC 827Val Phe Ile Pro Leu Asn Arg His Lys Asp Met Gln Leu Asp Ser Ala
245 250 255TTA TTG GCG ACT TTT GGC GAT GCT TTT GCC CTT GTG GAT GGT AGG GAT 875Leu Leu Ala Thr Phe Gly Asp Ala Phe Ala Leu Val Asp Gly Arg Asp
260 265 270TTA GGC AAT TAC GAG AGC AAA CTT TTT GAA AAA AGA GTG TCC TAT ACG 923Leu Gly Asn Tyr Glu Ser Lys Leu Phe Glu Lys Arg Val Ser Tyr Thr
275 280 285ATT GTC TAAAGGCATG AAATCTAGGA ATATTCCTTG ATAGCGGGCT TTCCTTTTTA GG 981Ile Val290
(2) Sequence 284 data:
(i) sequence characteristics:
(A) length: 291 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 284: met Lys Arg Arg Asp Phe Ile Lys Thr Thr Thr Leu Gly Ala Thr Gly 151015 Ala Val Leu Gly Ala Gln Ile Leu Gln Ala Glu Glu Ser Lys Gly Ser
20 25 30Val Ala Lys Tyr Lys Ile Glu Ala Gln Tyr Ser Ile Asp Phe Asp Ser
35 40 45Ala Glu His Thr Ser Leu Phe Ile Pro Met Pro Ser Val Val Ala Ser
50 55 60Asn Val His Leu Gln Gly Asn His Ala Ser Tyr Lys Ser Met Leu Asn65 70 75 80Phe Gly Val Pro Tyr Leu Gln Val Asp Phe Leu Lys Ser Thr Gln Lys
85 90 95Lys Gln Val His Leu Ser Tyr Glu Ile Ala Ser Tyr Gln Leu Asn Glu
100 105 110Arg Leu Phe Glu Thr Ser Asp Phe Val Ala Met Gly Arg Tyr Glu Arg
115 120 125Asp Asp Ala Ser Val Ala Asn Ile Ala Asn Gln Leu Lys Gly Thr Thr
130 135 140Pro Lys Glu Ser Val Arg Asn Phe Tyr Ala Phe Ile Lys His Glu Met145 150 155 160Pro Lys Arg Gln Lys Ala Leu Glu Gly Lys Glu Asn Leu Pro Lys Arg
165 170 175Glu Ser Leu Pro Trp Phe Ala Thr Ile Ser Lys Glu Ser Met Phe Val
180 185 190Ser Leu Cys His Ala Cys Gly Ile Lys Ser Ala Glu Val Gln Gly Leu
195 200 205Lys Leu Gly Gln Asn Ser Val Val Lys Asn Ala Pro Arg Val Glu Val
210 215 220Tyr Leu Lys Asp Ser Phe Leu Ala Phe Asp Phe Gln Asn Asn His Lys225 230 235 240Glu Val Phe Ile Pro Leu Asn Arg His Lys Asp Met Gln Leu Asp Ser
245 250 255Ala Leu Leu Ala Thr Phe Gly Asp Ala Phe Ala Leu Val Asp Gly Arg
260 265 270Asp Leu Gly Asn Tyr Glu Ser Lys Leu Phe Glu Lys Arg Val Ser Tyr
275 280 285Thr Ile Val
290
(2) Data in sequence 285:
(i) sequence characteristics:
(A) length: 686bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 82...633
(D) Other information:
(xi) Description of the sequence: sequence 285: TGTGATTAAA CAAAATCAAA AACTTTTTAA CTATAATCAA ACCTAAATTA AAGTTCAAGG 60AGTGGCATTT TGTTTAAAAG A ATG GTT TTA ATC GCT CTT TTA GGG GTG TTT 111
Met Val Leu Ile Ala Leu Leu Gly Val Phe
1 5 10TCA AGC GTT TCA TTA AGC GCT AAG AGT CTT TTA AGA GAT GAT GGG ATT 159Ser Ser Val Ser Leu Ser Ala Lys Ser Leu Leu Arg Asp Asp Gly Ile
15 20 25TTA GTC TCT GAT TTA AAG GGC ATG AAA TCA GAA CTA TCT GAT GCT CCT 207Leu Val Ser Asp Leu Lys Gly Met Lys Ser Glu Leu Ser Asp Ala Pro
30 35 40GCT TGG GTT TTT GAA GAC GCT AAA GCC CCC TAC GAA GAA ATG GGC GTG 255Ala Trp Val Phe Glu Asp Ala Lys Ala Pro Tyr Glu Glu Met Gly Val
45 50 55GCG TAT ATC CCT GTT AAT AAT AAA TAT TTA GGG ATT GAG CAA GCG ACC 303Ala Tyr Ile Pro Val Asn Asn Lys Tyr Leu Gly Ile Glu Gln Ala Thr
60 65 70TTA AAC GCT AAA TTG AGT CTG ATC GTG GTT TTT CAT GAA ATC ATG ATG 351Leu Asn Ala Lys Leu Ser Leu Ile Val Val Phe His Glu Ile Met Met7580 85 90AAG TAT AAA AAA CGC TTC ATG GAG CAA TTC CAT GAG TCC GAG CAG ACG 399Lys Tyr Lys Lys Arg Phe Met Glu Gln Phe His Glu Ser Glu Gln Thr
95 100 105ACT ACG AAT ATC AGT TAC GCT ATC TAT AAT TAT CTA GCG ACT AAG ATC 447Thr Thr Asn Ile Ser Tyr Ala Ile Tyr Asn Tyr Leu Ala Thr Lys Ile
110 115 120CAG GTA TCC AAC ACC TAC ACG AAT TTA AAA TCG GAG GTG GCG GTG GTG 495Gln Val Ser Asn Thr Tyr Thr Asn Leu Lys Ser Glu Val Ala Val Val
125 130 135AAA ATC AAG CTA GTG GGT TGT CAG ATT GAG CAA ATC AAA AGG TAT TTA 543Lys Ile Lys Leu Val Gly Cys Gln Ile Glu Gln Ile Lys Arg Tyr Leu
140 145 150AAA GCG AGC GTT GAA AAC CTT AAC GAT AAT GAA ATC GCT TAC ATC GCT 591Lys Ala Ser Val Glu Asn Leu Asn Asp Asn Glu Ile Ala Tyr Ile Ala155 160 165 170AAG GTC GCT CAA AAA GAA TTT GGT AGC GTT TGT GCG TTA AGG TAGTTTTAT 642Lys Val Ala Gln Lys Glu Phe Gly Ser Val Cys Ala Leu Arg
175 180AGCATTCTAG CGAGCATGTT TAAGGCATGC TCTACGCTTT TATT 686
(2) Sequence 286 data:
(i) sequence characteristics:
(A) length: 184 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 286: met Val Leu Ile Ala Leu Leu Gly Val Phe Ser Ser Val Ser Leu Ser 151015 Ala Lys Ser Leu Leu Arg Asp Asp Gly Ile Leu Val Ser Asp Leu Lys
20 25 30Gly Met Lys Ser Glu Leu Ser Asp Ala Pro Ala Trp Val Phe Glu Asp
35 40 45Ala Lys Ala Pro Tyr Glu Glu Met Gly Val Ala Tyr Ile Pro Val Asn
50 55 60Asn Lys Tyr Leu Gly Ile Glu Gln Ala Thr Leu Asn Ala Lys Leu Ser65 70 75 80Leu Ile Val Val Phe His Glu Ile Met Met Lys Tyr Lys Lys Arg Phe
85 90 95Met Glu Gln Phe His Glu Ser Glu Gln Thr Thr Thr Asn Ile Ser Tyr
100 105 110Ala Ile Tyr Asn Tyr Leu Ala Thr Lys Ile Gln Val Ser Asn Thr Tyr
115 120 125Thr Asn Leu Lys Ser Glu Val Ala Val Val Lys Ile Lys Leu Val Gly
130 135 140Cys Gln Ile Glu Gln Ile Lys Arg Tyr Leu Lys Ala Ser Val Glu Asn145 150 155 160Leu Asn Asp Asn Glu Ile Ala Tyr Ile Ala Lys Val Ala Gln Lys Glu
165 170 175Phe Gly Ser Val Cys Ala Leu Arg
180
(2) Sequence 287 data:
(i) sequence characteristics:
(A) length: 310bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 112...252
(D) Other information:
(xi) Description of the sequence: sequence 287: ATGCCTGCCA TTTCATAGCC TAAATTTTCT TTAGAGCCGA ATTGATAAGC GGCTTTTAAG 60ACTTCTTTTT GCTTAGCGTT AAAATCTTTA ATATTGTCGC AATTGGTCAT C ATG ACT 117
Met Thr
1TTA GTA ACG GGC GAT TTG GGC TTG TTT TTA ACC CCT TTA GCG GGC TTA 165Leu Val Thr Gly Asp Leu Gly Leu Phe Leu Thr Pro Leu Ala Gly Leu
5 10 15GGC TCT GTT TTA GTG GGG CTT TCT GTT GCG GCT AAA CTT AAA GAT GCA 213Gly Ser Val Leu Val Gly Leu Ser Val Ala Ala Lys Leu Lys Asp Ala
20 25 30CTT AAG GCT GTG CCT AGC CAT AAG GCT TTA AAG ATG GTG TGAGTGAGTG GG 264Leu Lys Ala Val Pro Ser His Lys Ala Leu Lys Met Val35 40 45GTTAAATGTT TCAAAACGCC TACCTTTTGT ATTAAGAAAT AAACTA 310
(2) Sequence 288 data:
(i) sequence characteristics:
(A) length: 47 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 288: met Thr Leu Val Thr Gly Asp Leu Gly Leu Phe Leu Thr Pro Leu Ala 151015 Gly Leu Gly Ser Val Leu Val Gly Leu Ser Val Ala Ala Lys Leu Lys
20 25 30Asp Ala Leu Lys Ala Val Pro Ser His Lys Ala Leu Lys Met Val
35 40 45
(2) Sequence 289 data:
(i) sequence characteristics:
(A) length: 631bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 145...579
(D) Other information:
(xi) Description of the sequence: sequence 289: GCGTTCAATA GAATGCTTTA GTTAGGAAGC TCCTTGCTTT AGCAAGGNGT GGTTTCACTG 60AAAGAGAGTA AGAAATTTGA AGAAAGGGTT TATCTTTTTT TAGATGAATT TGTGCGTTTT 120GGTAAATTGC CTTTTTTATT AGAA ATG CCA GCA TTA AGT AGG AGC TAT GGT 171
Met Pro Ala Leu Ser Arg Ser Tyr Gly
1 5GTG GTT TTA ATT TTT ATC ACG CAA TCC AAC GCT CTT ATT GAA AAA TAT 219Val Val Leu Ile Phe Ile Thr Gln Ser Asn Ala Leu Ile Glu Lys Tyr10 15 20 25TAC GGC AGA GAA GAT GCA AGA ATT GTT AAT AGC ACC GTG GCT TAC AAA 267Tyr Gly Arg Glu Asp Ala Arg Ile Val Asn Ser Thr Val Ala Tyr Lys
30 35 40ATA ATT TTC AAA ATG GAT GAT TTA GAA TAC GCT AAA CAG GTG AGC GAA 315Ile Ile Phe Lys Met Asp Asp Leu Glu Tyr Ala Lys Gln Val Ser Glu
45 50 55GAA GTC GGT AAG ATG ACT AGA AAA ACA CGA AGC CAC TCT ACA GAA AAA 363Glu Val Gly Lys Met Thr Arg Lys Thr Arg Ser His Ser Thr Glu Lys
60 65 70GGA CAA CTC ATT ACC GGA GGG ACT TCT AGT ATA GGT AAA GAG GCG TGG 411Gly Gln Leu Ile Thr Gly Gly Thr Ser Ser Ile Gly Lys Glu Ala Trp
75 80 85GAC TTA TTG AGC GCG CAA GAT ATT ATG AAT ATT GAT AAA GAT GAA GTG 459Asp Leu Leu Ser Ala Gln Asp Ile Met Asn Ile Asp Lys Asp Glu Val90 95 100 105ATC GTT TTA GTA AGC GGT CAT AAG GCT AAA CCC TTA AAA TTA AAA GCG 507Ile Val Leu Val Ser Gly His Lys Ala Lys Pro Leu Lys Leu Lys Ala
110 115 120AAT TAT TAT TTC AAA AAC AAA GAA TTA CTC TCT CGT ATT AAC TGG GAA 555Asn Tyr Tyr Phe Lys Asn Lys Glu Leu Leu Ser Arg Ile Asn Trp Glu
125 130 135GTC AAG CCC AAT GAA GAA GTG TTT TGATGGATTA AAAAAGTTTG CATGAGTATT 609Val Lys Pro Asn Glu Glu Val Phe
140 145TTTTAATTGC TTTTTTAAAA AT 631
(2) Sequence 290 data:
(i) sequence characteristics:
(A) length: 145 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 290: met Pro Ala Leu Ser Arg Ser Tyr Gly Val Val Leu Ile Phe Ile Thr 151015 Gln Ser Asn Ala Leu Ile Glu Lys Tyr Tyr Gly Arg Glu Asp Ala Arg
20 25 30Ile Val Asn Ser Thr Val Ala Tyr Lys Ile Ile Phe Lys Met Asp Asp
35 40 45Leu Glu Tyr Ala Lys Gln Val Ser Glu Glu Val Gly Lys Met Thr Arg
50 55 60Lys Thr Arg Ser His Ser Thr Glu Lys Gly Gln Leu Ile Thr Gly Gly65 70 75 80Thr Ser Ser Ile Gly Lys Glu Ala Trp Asp Leu Leu Ser Ala Gln Asp
85 90 95Ile Met Asn Ile Asp Lys Asp Glu Val Ile Val Leu Val Ser Gly His
100 105 110Lys Ala Lys Pro Leu Lys Leu Lys Ala Asn Tyr Tyr Phe Lys Asn Lys
115 120 125Glu Leu Leu Ser Arg Ile Asn Trp Glu Val Lys Pro Asn Glu Glu Val
130 135 140Phe145
(2) Sequence 291 data:
(i) sequence characteristics:
(A) length: 290bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 106...237
(D) Other information:
(xi) Description of the sequence: sequence 291: TAAGGGCTTA CGCATAAAAT CGCATCCGCG CCGATTTTTT GAGCGAACTT TGCTAAAGAA 60AGGGACTCGC TCGTGGCGTT ACTGCCCACG CCGGCTAACA CTTTC ATG CGC GAA TTT 117
Met Arg Glu Phe
1GAG GGC GTT TTA GTG TTT TTG CAA GTT TCT ATG GCG ATT TCA ATG CAA 165Glu Gly Val Leu Val Phe Leu Gln Val Ser Met Ala Ile Ser Met Gln 5 10 15 20CGC ATG TGC TCT TTG TGG GTG AGC GTG GCG GAT TCT CCT GTC GTG CCA 213Arg Met Cys Ser Leu Trp Val Ser Val Ala Asp Ser Pro Val Val Pro
25 30 35ACA GGC ACG CAT GCG TCC ATG CCC TGAAAAATTT GGCGCTTGAT CAAGGTTTCA 267Thr Gly Thr His Ala Ser Met Pro
40TAAGCGGCCT CATCAACGCT CAA 290
(2) Sequence 292 data:
(i) sequence characteristics:
(A) length: 44 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 292: met Arg Glu Phe Glu Gly Val Leu Val Phe Leu Gln Val Ser Met Ala 151015 Ile Ser Met Gln Arg Met Cys Ser Leu Trp Val Ser Val Ala Asp Ser
20 25 30Pro Val Val Pro Thr Gly Thr His Ala Ser Met Pro
35 40
(2) Sequence 293 data:
(i) sequence characteristics:
(A) length: 421bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 58...369
(D) Other information:
(xi) Description of the sequence: sequence 293: AAAGAAGGTT TGAAAAGCTT TTTTAAAAGG CTTTTGAAGT ATTTGGGGTA GGCTTGA ATG 60
Met
1AAA GTG CAA AAT TTT ATC CAT TTT TCT GTT GTG GTA GGG TTT TTT TTG 108Lys Val Gln Asn Phe Ile His Phe Ser Val Val Val Gly Phe Phe Leu
5 10 15GGG TTA GTG TTT TCG GTG TTG AAA TTC AAT GAG CCA GAG AGC ATT TTA 156Gly Leu Val Phe Ser Val Leu Lys Phe Asn Glu Pro Glu Ser Ile Leu
20 25 30TTA TGG ACG GTG TTA TCC ACG CTT GGG GGG TAC TTG ATT GCG TTG TTG 204Leu Trp Thr Val Leu Ser Thr Leu Gly Gly Tyr Leu Ile Ala Leu Leu
35 40 45TTT GCG TCT ATT TTT ATC GCT TGC ACG GAT TTG GAT ATT TGT CTT TTT 252Phe Ala Ser Ile Phe Ile Ala Cys Thr Asp Leu Asp Ile Cys Leu Phe50 55 60 65GAC AAA AAA GGC ACT GAA GAG AGT TTG CTT CGT TTC AAC CAT GAG TTT 300Asp Lys Lys Gly Thr Glu Glu Ser Leu Leu Arg Phe Asn His Glu Phe
70 75 80AAA AAC AGA GAA AAA GAA GTG GCT AGT ATT TTA GAA TAC ATT AGA AGT 348Lys Asn Arg Glu Lys Glu Val Ala Ser Ile Leu Glu Tyr Ile Arg Ser
85 90 95TAT GAT TTT GAT GAT GGA AAA TAGAATGCCC AAAGGAATTC AAAAAACTGA AACA 403Tyr Asp Phe Asp Asp Gly Lys
100AGCGAAAAAA ATATAGAA 421
(2) Data of sequence 294:
(i) sequence characteristics:
(A) length: 104 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 294: met Lys Val Gln Asn Phe Ile His Phe Ser Val Val Val Gly Phe Phe 151015 Leu Gly Leu Val Phe Ser Val Leu Lys Phe Asn Glu Pro Glu Ser Ile
20 25 30Leu Leu Trp Thr Val Leu Ser Thr Leu Gly Gly Tyr Leu Ile Ala Leu
35 40 45Leu Phe Ala Ser Ile Phe Ile Ala Cys Thr Asp Leu Asp Ile Cys Leu
50 55 60Phe Asp Lys Lys Gly Thr Glu Glu Ser Leu Leu Arg Phe Asn His Glu65 70 75 80Phe Lys Asn Arg Glu Lys Glu Val Ala Ser Ile Leu Glu Tyr Ile Arg
85 90 95Ser Tyr Asp Phe Asp Asp Gly Lys
100
(2) Sequence 295 data:
(i) sequence characteristics:
(A) length: 670bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...617
(D) Other information:
(xi) Description of the sequence: sequence 295: GTTTAGAAAA GCGTTTGAAC GCTATAAAAA ATGCAGAGTG GCTTTAAGGC ATG AAA 56
Met LysAAG ATT GCA TTT TTT ATT TTT GTC ATT TTG TTT TCG GTA GGG ATT TAT 104Lys Ile Ala Phe Phe Ile Phe Val Ile Leu Phe Ser Val Gly Ile Tyr
5 10 15TTA ATT TGG CAT GTT TTA TTG GAA AAA GCC CTA GAA TTG AAA TTA GCA 152Leu Ile Trp His Val Leu Leu Glu Lys Ala Leu Glu Leu Lys Leu Ala
20 25 30ACC TCA GCT AAT GAT TTG CTT TTA AAA TTG TTG GCA ATT CTT GGC GTT 200Thr Ser Ala Asn Asp Leu Leu Leu Lys Leu Leu Ala Ile Leu Gly Val35 40 45 50TTT TCA ATG TTA GTG CTT TTT CAA GGC ATT ATT TCT TCG TAT AAG AAG 248Phe Ser Met Leu Val Leu Phe Gln Gly Ile Ile Ser Ser Tyr Lys Lys
55 60 65CGC CAA CTC AAA CGC ATT TTA CAA AAA ATA GAC GCC ATG AAC GGC TTT 296Arg Gln Leu Lys Arg Ile Leu Gln Lys Ile Asp Ala Met Asn Gly Phe
70 75 80GAA TTT GAA GAA TAT TCC AAA ATC TTT TTC ACT TCA AAG GGT TTT GAA 344Glu Phe Glu Glu Tyr Ser Lys Ile Phe Phe Thr Ser Lys Gly Phe Glu
85 90 95GTG AGC ATC ACG CAA AAA AGC GGC GAT TAT GGA GCG GAT TTG ATT ATA 392Val Ser Ile Thr Gln Lys Ser Gly Asp Tyr Gly Ala Asp Leu Ile Ile
100105 110GAA AAA GAC GGC ATC AAG TGG GCG GTT CAA GTC AAA CGC TAC TCG CAT 440Glu Lys Asp Gly Ile Lys Trp Ala Val Gln Val Lys Arg Tyr Ser His115 120 125 130AAA GTT TCG CCC AAA GCC ATT CAA GAG GTG GTC TCT TCT AAA GCT TAT 488Lys Val Ser Pro Lys Ala Ile Gln Glu Val Val Ser Ser Lys Ala Tyr
135 140 145TAC GCT TGC GAA AAA GCT TGC GTG ATC ACC AAC AGC TAT TTC ACG CAA 536Tyr Ala Cys Glu Lys Ala Cys Val Ile Thr Asn Ser Tyr Phe Thr Gln
150 155 160GCC GCT CAA AAA CTG GCT CAA GCT AAC GAA GTG CTC TTG ATT GAC AGA 584Ala Ala Gln Lys Leu Ala Gln Ala Asn Glu Val Leu Leu Ile Asp Arg
165 170 175GAC GAA TGG GTC AGG TTT TTG AAC GAA AAG AGA TGAACCGATC CCATCAGATC 637Asp Glu Trp Val Arg Phe Leu Asn Glu Lys Arg
180 185GTTTGTTCTC AAGTTCTTTT AAAATTTTGT CGT 670
(2) Sequence 296 data:
(i) sequence characteristics:
(A) length: 189 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 296: met Lys Lys Ile Ala Phe Phe Ile Phe Val Ile Leu Phe Ser Val Gly 151015 Ile Tyr Leu Ile Trp His Val Leu Leu Glu Lys Ala Leu Glu Leu Lys
20 25 30Leu Ala Thr Ser Ala Asn Asp Leu Leu Leu Lys Leu Leu Ala Ile Leu
35 40 45Gly Val Phe Ser Met Leu Val Leu Phe Gln Gly Ile Ile Ser Ser Tyr
50 55 60Lys Lys Arg Gln Leu Lys Arg Ile Leu Gln Lys Ile Asp Ala Met Asn65 70 75 80Gly Phe Glu Phe Glu Glu Tyr Ser Lys Ile Phe Phe Thr Ser Lys Gly
85 90 95Phe Glu Val Ser Ile Thr Gln Lys Ser Gly Asp Tyr Gly Ala Asp Leu
100 105 110Ile Ile Glu Lys Asp Gly Ile Lys Trp Ala Val Gln Val Lys Arg Tyr
115 120 125Ser His Lys Val Ser Pro Lys Ala Ile Gln Glu Val Val Ser Ser Lys
130 135 140Ala Tyr Tyr Ala Cys Glu Lys Ala Cys Val Ile Thr Asn Ser Tyr Phe145 150 155 160Thr Gln Ala Ala Gln Lys Leu Ala Gln Ala Asn Glu Val Leu Leu Ile
165 170 175Asp Arg Asp Glu Trp Val Arg Phe Leu Asn Glu Lys Arg
180 185
(2) Sequence 297 material:
(i) sequence characteristics:
(A) length: 600bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 125...538
(D) Other information:
(xi) Description of the sequence: sequence 297: CAAAGAGTGG GATAAAATCA CAGAAATTTG TAAGAGAGCG CTAGCTTTAA GATAACAAAA 60AGATCATGGC ATTTTGTATT TGCTTAATAA CACTATAATA AAATTTTTAA TAAGGAGATA 120CATC ATG TTA GAA AAT GTC AAA AAG TCC TTT TTT AGG GTT TTG TGC TTG 169
Met Leu Glu Asn Val Lys Lys Ser Phe Phe Arg Val Leu Cys Leu
1 5 10 15GGT GCG TTG TGT TTA GGG GGG CTA ATG GCA GAG CAA GAC CCT AAA GAG 217Gly Ala Leu Cys Leu Gly Gly Leu Met Ala Glu Gln Asp Pro Lys Glu
20 25 30CTT GTG GGT TTG GGG GCA AAG AGC TAC AAA GAG AAA GAT TTC ACT CAA 265Leu Val Gly Leu Gly Ala Lys Ser Tyr Lys Glu Lys Asp Phe Thr Gln
35 40 45GCG AAG AAA TAT TTT GAG AAA GCG TGC GAT TTG AAA GAA AAT AGC GGG 313Ala Lys Lys Tyr Phe Glu Lys Ala Cys Asp Leu Lys Glu Asn Ser Gly
50 55 60TGT TTT AAT TTA GGG GTG CTT TAT TAT CAA GGG CAA GGG GTG GAA AAG 361Cys Phe Asn Leu Gly Val Leu Tyr Tyr Gln Gly Gln Gly Val Glu Lys
65 70 75AAC TTG AAA AAA GCC GCC TCC TTT TAC GCT AAA GCT TGC GAT TTG AAT 409Asn Leu Lys Lys Ala Ala Ser Phe Tyr Ala Lys Ala Cys Asp Leu Asn80 85 90 95TAC AGC AAT GGG TGT CAT TTG CTA GGG AAT TTA TAT TAC AGC GGG CAA 457Tyr Ser Asn Gly Cys His Leu Leu Gly Asn Leu Tyr Tyr Ser Gly Gln
100 105 110GGC GTG TCC CAA AAC ACC AAT AAA GCC CTA CAA TAC TAC TCT AAA GCG 505Gly Val Ser Gln Asn Thr Asn Lys Ala Leu Gln Tyr Tyr Ser Lys Ala
115 120 125TGC GAT TTG AAA TAC GCT GAA GGG TGC GCG ACT TAGGGGGGAT TTATCATGAT 558Cys Asp Leu Lys Tyr Ala Glu Gly Cys Ala Thr
130 135GGTAAAGTGG TAACTAGGGA TTTTAAAAAA GCGGTGGAAT AT 600
(2) Sequence 298 data:
(i) sequence characteristics:
(A) length: 138 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 298: met Leu Glu Asn Val Lys Lys Ser Phe Phe Arg Val Leu Cys Leu Gly 151015 Ala Leu Cys Leu Gly Gly Leu Met Ala Glu Gln Asp Pro Lys Glu Leu
20 25 30Val Gly Leu Gly Ala Lys Ser Tyr Lys Glu Lys Asp Phe Thr Gln Ala
35 40 45Lys Lys Tyr Phe Glu Lys Ala Cys Asp Leu Lys Glu Asn Ser Gly Cys
50 55 60Phe Asn Leu Gly Val Leu Tyr Tyr Gln Gly Gln Gly Val Glu Lys Asn65 70 75 80Leu Lys Lys Ala Ala Ser Phe Tyr Ala Lys Ala Cys Asp Leu Asn Tyr
85 90 95Ser Asn Gly Cys His Leu Leu Gly Asn Leu Tyr Tyr Ser Gly Gln Gly
100 105 110Val Ser Gln Asn Thr Asn Lys Ala Leu Gln Tyr Tyr Ser Lys Ala Cys
115 120 125Asp Leu Lys Tyr Ala Glu Gly Cys Ala Thr
130 135
(2) Sequence 299 data:
(i) sequence characteristics:
(A) length: 879bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 59...826
(D) Other information:
(xi) Description of the sequence: sequence 299: TTTTAAGATT GGTAGCCATT GGCATTATGT TTGATCTTAT TAAAGCAGAG GAGTAACA 58ATG GGA TAC GCA AGC AAA TTA GCC TTG AAG ATT TGT TTG GCA AGT TTA 106Met Gly Tyr Ala Ser Lys Leu Ala Leu Lys Ile Cys Leu Ala Ser Leu 151015 TGT TTA TTT AGC GCT CTT GGT GCA GAA CAC CTT GAA CAA AAA AGG AAC 154Cys Leu Phe Ser Ala Leu Gly Ala Glu His Leu Glu Gln Lys Arg Asn
20 25 30TAT ATT TAT AAM GGG GAG GAA GCC TAT AAT AAT AAG GAA TAT GAG CGG 202Tyr Ile Tyr Xaa Gly Glu Glu Ala Tyr Asn Asn Lys Glu Tyr Glu Arg
35 40 45GCG GCT TCT TTT TAT AAG AGC GCG ATT AAA AAT GGC GAG CCG CTT GCT 250Ala Ala Ser Phe Tyr Lys Ser Ala Ile Lys Asn Gly Glu Pro Leu Ala
50 55 60TAT GTT CTT TTA GGG ATC ATG TAT GAA AAT GGT AGG GGT GTG CCT AAA 298Tyr Val Leu Leu Gly Ile Met Tyr Glu Asn Gly Arg Gly Val Pro Lys65 70 75 80GAT GAA AAG AAA GCG GCT GAA TAT TTT CAA AAA GCG GTT GAT AAC GAT 346Asp Glu Lys Lys Ala Ala Glu Tyr Phe Gln Lys Ala Val Asp Asn Asp
85 90 95ATA CCT AGA GGGTAT AAC AAT TTA GGC GTG ATG TAT AAA GAG GGT AGA 394Ile Pro Arg Gly Tyr Asn Asn Leu Gly Val Met Tyr Lys Glu Gly Arg
100 105 110GGT GTG CCT AAA GAT GAA AAG AAA GCC GTG GAG TAT TTT AGA ATA GCT 442Gly Val Pro Lys Asp Glu Lys Lys Ala Val Glu Tyr Phe Arg Ile Ala
115 120 125ACC GAG AAG GGC TAT ACT AAC GCC TAT ATA AAC TTA GGC ATC ATG TAT 490Thr Glu Lys Gly Tyr Thr Asn Ala Tyr Ile Asn Leu Gly Ile Met Tyr
130 135 140ATG GAG GGT AGG GGA GTT CCA AGC AAC TAT GTG AAA GCG ACA GAG TGC 538Met Glu Gly Arg Gly Val Pro Ser Asn Tyr Val Lys Ala Thr Glu Cys145 150 155 160TTT AGA AAA GCG ATG CAT AAG GGT AAT GTA GAA GCT TAT ATC CTT TTA 586Phe Arg Lys Ala Met His Lys Gly Asn Val Glu Ala Tyr Ile Leu Leu
165 170 175GGG GAT ATT TAT TAT AGT GGG AAT GAT CAA TTG GGT ATT GAG CCA GAC 634Gly Asp Ile Tyr Tyr Ser Gly Asn Asp Gln Leu Gly Ile Glu Pro Asp
180 185 190AAA GAT AAG GCG ATT GTC TAT TAT AAA ATG GCG GCT GAT ATG AGC TCT 682Lys Asp Lys Ala Ile Val Tyr Tyr Lys Met Ala Ala Asp Met Ser Ser
195 200 205TCT AGA GCT TAT GAA GGG TTA GCA GAG TCT TAT CAG TAT GGG TTA GGC 730Ser Arg Ala Tyr Glu Gly Leu Ala Glu Ser Tyr Gln Tyr Gly Leu Gly
210 215 220GTG GAA AAA GAT AAG AAA AAG GCT GAA GAA TAC ATG CAA AAA GCA TGC 778Val Glu Lys Asp Lys Lys Lys Ala Glu Glu Tyr Met Gln Lys Ala Cys225 230 235 240GAT TTT GAC ATT GAT AAA AAT TGT AAG AAA AAG AAC ACT TCA AGC CGA 826Asp Phe Asp Ile Asp Lys Asn Cys LysLys Lys Asn Thr Ser Ser Arg
245 250 255TAACTCTCAA ACTTGGGCTT GATTAGGATT TTTGTTTTAT TTTAAGTAGC ATG 879
(2) Sequence 300 data:
(i) sequence characteristics:
(A) length: 256 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 300: met Gly Tyr Ala Ser Lys Leu Ala Leu Lys Ile Cys Leu Ala Ser Leu 151015 Cys Leu Phe Ser Ala Leu Gly Ala Glu His Leu Glu Gln Lys Arg Asn
20 25 30Tyr Ile Tyr Xaa Gly Glu Glu Ala Tyr Asn Asn Lys Glu Tyr Glu Arg
35 40 45Ala Ala Ser Phe Tyr Lys Ser Ala Ile Lys Asn Gly Glu Pro Leu Ala
50 55 60Tyr Val Leu Leu Gly Ile Met Tyr Glu Asn Gly Arg Gly Val Pro Lys65 70 75 80Asp Glu Lys Lys Ala Ala Glu Tyr Phe Gln Lys Ala Val Asp Asn Asp
85 90 95Ile Pro Arg Gly Tyr Asn Asn Leu Gly Val Met Tyr Lys Glu Gly Arg
100 105 110Gly Val Pro Lys Asp Glu Lys Lys Ala Val Glu Tyr Phe Arg Ile Ala
115 120 125Thr Glu Lys Gly Tyr Thr Asn Ala Tyr Ile Asn Leu Gly Ile Met Tyr
130 135 140Met Glu Gly Arg Gly Val Pro Ser Asn Tyr Val Lys Ala Thr Glu Cys145 150 155 160Phe Arg Lys Ala Met His Lys Gly Asn Val Glu Ala Tyr Ile Leu Leu
165 170 175Gly Asp Ile Tyr Tyr Ser Gly Asn Asp Gln Leu Gly Ile Glu Pro Asp
180 185 190Lys Asp Lys Ala Ile Val Tyr Tyr Lys Met Ala Ala Asp Met Ser Ser
195 200 205Ser Arg Ala Tyr Glu Gly Leu Ala Glu Ser Tyr Gln Tyr Gly Leu Gly
210 215 220Val Glu Lys Asp Lys Lys Lys Ala Glu Glu Tyr Met Gln Lys Ala Cys225 230 235 240Asp Phe Asp Ile Asp Lys Asn Cys Lys Lys Lys Asn Thr Ser Ser Arg
245 250 255
(2) Sequence 301 data:
(i) sequence characteristics:
(A) length: 319bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 66...269
(D) Other information:
(xi) Description of the sequence: sequence 301: TGGGGGTTGT GGTTGCTCAT GTTCGCATGG GTAGTAAGGT ATAGGAGTAT TTAAAAGGCA 60AGGTC ATG AAT AGT TCT AAT CTC AAA AAT TGG CTA TTC CCT ACC ATT TGC 110
Met Asn Ser Ser Asn Leu Lys Asn Trp Leu Phe Pro Thr Ile Cys
1 510 15TTT TTT TTA TTT TGT TAT ATT TTA ATT TTT TTA ATG TTC TTT ATG TTT 158Phe Phe Leu Phe Cys Tyr Ile Leu Ile Phe Leu Met Phe Phe Met Phe
20 25 30AAA AGT TTG CAA TCG CAA TCG TTT GGC TCT GTG GCA GAA ACC GGA AAA 206Lys Ser Leu Gln Ser Gln Ser Phe Gly Ser Val Ala Glu Thr Gly Lys
35 40 45AAA CCC ATC ACC ACC ACC AAG AAA TTT GGT AAG GAA TTG CAA AAA CAG 254Lys Pro Ile Thr Thr Thr Lys Lys Phe Gly Lys Glu Leu Gln Lys Gln
50 55 60ATT TCA AAA ATC CAT TAACTTTTTT TCTTTTTTGC CGATACTTGC TGTAATGGAA T 310Ile Ser Lys Ile His
65GAATATCAA 319
(2) Sequence 302 data:
(i) sequence characteristics:
(A) length: 68 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 302: met Asn Ser Ser Asn Leu Lys Asn Trp Leu Phe Pro Thr Ile Cys Phe 151015 Phe Leu Phe Cys Tyr Ile Leu Ile Phe Leu Met Phe Phe Met Phe Lys
20 25 30Ser Leu Gln Ser Gln Ser Phe Gly Ser Val Ala Glu Thr Gly Lys Lys
35 40 45Pro Ile Thr Thr Thr Lys Lys Phe Gly Lys Glu Leu Gln Lys Gln Ile
50 55 60Ser Lys Ile His65
(2) Sequence 303 data:
(i) sequence characteristics:
(A) length: 1112bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 66...1058
(D) Other information:
(xi) Description of the sequence: sequence 303: AAAAACTAGA GAGTGTTATA AAGAAAACAG AAGAGTGGAT GTCAAATTAA TGAAGTAATT 60CTAGG ATG AAA AGG CTT TTT TTT ATC CCT TTT ATC GCT CCC TTT TTT CTC 110
Met Lys Arg Leu Phe Phe Ile Pro Phe Ile Ala Pro Phe Phe Leu
1 5 10 15AAT GGG GAG CCT TCA GCG TTT GAT TTG CAA AGT GGG GCT ACC AAA AAA 158Asn Gly Glu Pro Ser Ala Phe Asp Leu Gln Ser Gly Ala Thr Lys Lys
20 25 30GAA CTC AAG CAG TTG CAA ATC AAT AGT AAG AAT TTT TCT AAT ATT TTG 206Glu Leu Lys Gln Leu Gln Ile Asn Ser Lys Asn Phe Ser Asn Ile Leu
35 40 45ACC AAA ATC CAT TCG CAA GTA GAG GCT AAC ACT CAA GCT CAA GAG GGT 254Thr Lys Ile His Ser Gln Val Glu Ala Asn Thr Gln Ala Gln Glu Gly
50 55 60TTG AGA AGC GTT TAT GAG GGG CAG GCT AAT AAG ATT AAA GAT CTC AAT 302Leu Arg Ser Val Tyr Glu Gly Gln Ala Asn Lys Ile Lys Asp Leu Asn
65 70 75AAC GCT ATC CTT TCC CAA GAA GAA TCC TTA CGA GCC TTA AAA GCT TCG 350Asn Ala Ile Leu Ser Gln Glu Glu Ser Leu Arg Ala Leu Lys Ala Ser80 85 90 95CAA GAA GTG CAG GCT AAC ACG CTT AAG CAG CAA TCG CAA ACT TTA GAG 398Gln Glu Val Gln Ala Asn Thr Leu Lys Gln Gln Ser Gln Thr Leu Glu
100 105 110GAT TTG AGG AAT GAG ATT CAC GCT AAC CAG CAA GCT ATC CAG CAG TTA 446Asp Leu Arg Asn Glu Ile His Ala Asn Gln Gln Ala Ile Gln Gln Leu
115 120 125GAC AAG CAA AAT AAA GAG ATG AGT GAA TTA TTG ACC AAG TTA AGC CAG 494Asp Lys Gln Asn Lys Glu Met Ser Glu Leu Leu Thr Lys Leu Ser Gln
130 135 140GAT TTG GTT TCA CAA ATC GCC TTA ATC CAA AAA GCT CTC AAA GAA CAA 542Asp Leu Val Ser Gln Ile Ala Leu Ile Gln Lys Ala Leu Lys Glu Gln
145 150 155GAG GAA AAA GCT GAA AAG CCG CTC AAA TCA AAC GCT CCG GCT AAT AAA 590Glu Glu Lys Ala Glu Lys Pro Leu Lys Ser Asn Ala Pro Ala Asn Lys160 165 170 175ACC CCC TCT TTG AAA GCC GAA TCC CCA AAA AAT CAA GAG GGA AAA ACT 638Thr Pro Ser Leu Lys Ala Glu Ser Pro Lys Asn Gln Glu Gly Lys Thr
180 185 190CAA GAA AAG GCG AAA ATT GAG TTT GAT AAA GAC TTG TCT AAG CAA AAA 686Gln Glu Lys Ala Lys Ile Glu Phe Asp Lys Asp Leu Ser Lys Gln Lys
195 200 205GAG ATC TTT CAA GAA GCT CTG TCT TTT TTT AAA AAT AAA TCC TAT GCA 734Glu Ile Phe Gln Glu Ala Leu Ser Phe Phe Lys Asn Lys Ser Tyr Ala
210 215 220GAA GCC AAA GAG CGT TTG TTG TGG TTA GAA GCC AAT AGT TAC AGA CTT 782Glu Ala Lys Glu Arg Leu Leu Trp Leu Glu Ala Asn Ser Tyr Arg Leu
225 230 235TAT TAT GTG CGT TAT GTT CTT GGA GAA GTG GCT TAT GGG GAA AAG AGA 830Tyr Tyr Val Arg Tyr Val Leu Gly Glu Val Ala Tyr Gly Glu Lys Arg240 245 250 255TAC AGA GAA GCG ATC AAG TAT TAC AAA GAG AGC GCT CTT TTA AAC AAA 878Tyr Arg Glu Ala Ile Lys Tyr Tyr Lys Glu Ser Ala Leu Leu Asn Lys
260 265 270AAA GCG TCT TAC ATG CCT GTG CTT TTG TGG CAT ACG GCA TGG TCG TTT 926Lys Ala Ser Tyr Met Pro Val Leu Leu Trp His Thr Ala Trp Ser Phe
275 280 285AAA AAA ATC AAA GAC GAT CAA AAC TAT TAT AAA TTT TTA AAC ACT TTG 974Lys Lys Ile Lys Asp Asp Gln Asn Tyr Tyr Lys Phe Leu Asn Thr Leu
290 295 300CAA CAC TTG TAT CCT TCA AGC GAA CAA GCT AAA ATG GCG CAA AAA ATC 1022Gln His Leu Tyr Pro Ser Ser Glu Gln Ala Lys Met Ala Gln Lys Ile
305 310 315TTA GAA AAC AAG GAG AAA CAC CAC CAT GCA AAA CCA TGATTTAGAG TCAATC 1074Leu Glu Asn Lys Glu Lys His His His Ala Lys Pro320 325 330AAACAAGCCG CTTTGATTGA ATATGAAGTG AGAGAACA 1112
(2) Sequence 304 data:
(i) sequence characteristics:
(A) length: 331 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 304: met Lys Arg Leu Phe Phe Ile Pro Phe Ile Ala Pro Phe Phe Leu Asn 151015 Gly Glu Pro SerAla Phe Asp Leu Gln Ser Gly Ala Thr Lys Lys Glu
20 25 30Leu Lys Gln Leu Gln Ile Asn Ser Lys Asn Phe Ser Asn Ile Leu Thr
35 40 45Lys Ile His Ser Gln Val Glu Ala Asn Thr Gln Ala Gln Glu Gly Leu
50 55 60Arg Ser Val Tyr Glu Gly Gln Ala Asn Lys Ile Lys Asp Leu Asn Asn65 70 75 80Ala Ile Leu Ser Gln Glu Glu Ser Leu Arg Ala Leu Lys Ala Ser Gln
85 90 95Glu Val Gln Ala Asn Thr Leu Lys Gln Gln Ser Gln Thr Leu Glu Asp
100 105 110Leu Arg Asn Glu Ile His Ala Asn Gln Gln Ala Ile Gln Gln Leu Asp
115 120 125Lys Gln Asn Lys Glu Met Ser Glu Leu Leu Thr Lys Leu Ser Gln Asp
130 135 140Leu Val Ser Gln Ile Ala Leu Ile Gln Lys Ala Leu Lys Glu Gln Glu145 150 155 160Glu Lys Ala Glu Lys Pro Leu Lys Ser Asn Ala Pro Ala Asn Lys Thr
165 170 175Pro Ser Leu Lys Ala Glu Ser Pro Lys Asn Gln Glu Gly Lys Thr Gln
180 185 190Glu Lys Ala Lys Ile Glu Phe Asp Lys Asp Leu Ser Lys Gln Lys Glu
195 200 205Ile Phe Gln Glu Ala Leu Ser Phe Phe Lys Asn Lys Ser Tyr Ala Glu
210 215 220Ala Lys Glu Arg Leu Leu Trp Leu Glu Ala Asn Ser Tyr Arg Leu Tyr225 230 235 240Tyr Val Arg Tyr Val Leu Gly Glu Val Ala TyrGly Glu Lys Arg Tyr
245 250 255Arg Glu Ala Ile Lys Tyr Tyr Lys Glu Ser Ala Leu Leu Asn Lys Lys
260 265 270Ala Ser Tyr Met Pro Val Leu Leu Trp His Thr Ala Trp Ser Phe Lys
275 280 285Lys Ile Lys Asp Asp Gln Asn Tyr Tyr Lys Phe Leu Asn Thr Leu Gln
290 295 300His Leu Tyr Pro Ser Ser Glu Gln Ala Lys Met Ala Gln Lys Ile Leu305 310 315 320Glu Asn Lys Glu Lys His His His Ala Lys Pro
325 330
(2) Sequence 305 data:
(i) sequence characteristics:
(A) length: 531bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...483
(D) Other information:
(xi) Description of the sequence: sequence 305: AACAAATGCG AGTTTCAAAT ATTTTGTAGG ATTTTAGGAA AGAAATAGGT T ATG AAT 57
Met Asn
1ATA TCG GTT AAC CCC TAT TTA ATG GCG GTC GTT TTT GTG GTG TTT GTG 105Ile Ser Val Asn Pro Tyr Leu Met Ala Val Val Phe Val Val Phe Val
5 10 15TTA TTG TTA TGG GCG ATG AAT GTT TGG GTG TAT AGG CCT TTG TTG GCT 153Leu Leu Leu Trp Ala Met Asn Val Trp Val Tyr Arg Pro Leu Leu Ala
20 25 30TTT ATG GAT AAC AGA CAG GCA GAG ATA AAG GAT AGC TTG GCT AAA ATC 201Phe Met Asp Asn Arg Gln Ala Glu Ile Lys Asp Ser Leu Ala Lys Ile35 40 45 50AAA ACG GAT AAT GCC CAA AGT GTG GAG ATT GGC CAT CAA ATT GAG GCT 249Lys Thr Asp Asn Ala Gln Ser Val Glu Ile Gly His Gln Ile Glu Ala
55 60 65CTT CTT AAA GAA GCG GCT GAA AAA CGC AGA GAA ATA ATA GCA GAA GCG 297Leu Leu Lys Glu Ala Ala Glu Lys Arg Arg Glu Ile Ile Ala Glu Ala
70 75 80ATT CAA AAA GCC ACA GAG TCC TAT GAC GCT GTG ATC AAG CAA AAA GAG 345Ile Gln Lys Ala Thr Glu Ser Tyr Asp Ala Val Ile Lys Gln Lys Glu
85 90 95AAC GAA CTC AAT CAA GAG TTT GAA GCG TTT GCG AAG CAA TTA CAA AAT 393Asn Glu Leu Asn Gln Glu Phe Glu Ala Phe Ala Lys Gln Leu Gln Asn
100 105 110GAA AAG CAA GCG CTA AAA GAG CAG TTG CAA GCG CAA ATG CCG GTA TTT 441Glu Lys Gln Ala Leu Lys Glu Gln Leu Gln Ala Gln Met Pro Val Phe115 120 125 130GAA GAC GAG TTA AAC AAG CGT GTG GCT ATG GGT TTA GGG AGT TGATGAATG 492Glu Asp Glu Leu Asn Lys Arg Val Ala Met Gly Leu Gly Ser
135 140TTTGTAGTTA AAATGGTGTT AGGGTTTTTG ATCCTTTTA 531
(2) Sequence 306 data:
(i) sequence characteristics:
(A) length: 144 amino acids
(B) Type (2): amino acids
(C)Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 306: met Asn Ile Ser Val Asn Pro Tyr Leu Met Ala Val Val Phe Val Val 151015 Phe Val Leu Leu Leu Trp Ala Met Asn Val Trp Val Tyr Arg Pro Leu
20 25 30Leu Ala Phe Met Asp Asn Arg Gln Ala Glu Ile Lys Asp Ser Leu Ala
35 40 45Lys Ile Lys Thr Asp Asn Ala Gln Ser Val Glu Ile Gly His Gln Ile
50 55 60Glu Ala Leu Leu Lys Glu Ala Ala Glu Lys Arg Arg Glu Ile Ile Ala65 70 75 80Glu Ala Ile Gln Lys Ala Thr Glu Ser Tyr Asp Ala Val Ile Lys Gln
85 90 95Lys Glu Asn Glu Leu Asn Gln Glu Phe Glu Ala Phe Ala Lys Gln Leu
100 105 110Gln Asn Glu Lys Gln Ala Leu Lys Glu Gln Leu Gln Ala Gln Met Pro
115 120 125Val Phe Glu Asp Glu Leu Asn Lys Arg Val Ala Met Gly Leu Gly Ser
130 135 140
(2) Sequence 307 data:
(i) sequence characteristics:
(A) length: 5832bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized inthat:
(A) name/keyword: coding sequence
(B) Position: 387...5777
(D) Other information:
(xi) Description of the sequence: sequence 307: AAGCTTGATA TGGAGCATTT TGATCGCTTG ACCATGCTCA ATAGAGAAGA ATTGTTGCGC 60GTTACTCGCT CCTTTCTCAA GCGATTTTAG AAGAGCCTTT CAGCCATAAC GGCAAGGATT 120ATAAAGAAGG CGATCAAATC CCTAAAGAAG AAATCGCTTC AATCAACCGC TTCACTTTGG 180CTAGTTTGGT CAAAAAGTAT TCTAAAGAAG TGCAAAACCA CTATGAAATC ACTAAAAACA 240ATTTCTTAGA GCAAAAGAAA GTTTTGGGCG AAGAGCATGA AGAAAAGCTT TCTATTTTAG 300AAAAAGATGA TATTTTGCCT AATGGCGTGA TCAAAAAAGT CAAGCTCTAT ATCGCTACAA 360AACGAAAGCT TAAAGTGGGC GATAAA ATG GCA GGA AGG CAT GGG AAT AAA GGG 413
Met Ala Gly Arg His Gly Asn Lys Gly
1 5ATT GTG TCT AAT ATC GTG CCG GTT GCG GAT ATG CCT TAT ACC GCT GAT 461Ile Val Ser Asn Ile Val Pro Val Ala Asp Met Pro Tyr Thr Ala Asp10 15 20 25GGC GAG CCT GTA GAT ATT GTT TTA AAC CCT TTA GGC GTG CCA AGC CGC 509Gly Glu Pro Val Asp Ile Val Leu Asn Pro Leu Gly Val Pro Ser Arg
30 35 40ATG AAT ATC GGG CAG ATT TTA GAA ATG CAT TTA GGC TTA GTG GGG AAA 557Met Asn Ile Gly Gln Ile Leu Glu Met His Leu Gly Leu Val Gly Lys
45 50 55GAA TTT GGG AAG CAA ATC GCT CGC ATG CTA GAG GAT AAA ACC AAA GAT 605Glu Phe Gly Lys Gln Ile Ala Arg Met Leu Glu Asp Lys Thr Lys Asp
60 65 70TTT GCC AAA GAA TTG CGT GCT AAA ATG CTA GAA AWC GCT AAC GCT ATT 653Phe Ala Lys Glu Leu Arg Ala Lys Met Leu Glu Xaa Ala Asn Ala Ile
75 80 85AAT GAA AAA GAC CCC TTG ACA ATC CAT GCG CTT GAG AAT TGT TCT GAT 701Asn Glu Lys Asp Pro Leu Thr Ile His Ala Leu Glu Asn Cys Ser Asp90 95 100 105GAA GAG CTT TTG GAA TAC GCA AAA GAT TGG AGC AAG GGC GTT AAG ATG 749Glu Glu Leu Leu Glu Tyr Ala Lys Asp Trp Ser Lys Gly Val Lys Met
110 115 120GCT ATC CCT GTG TTT GAA GGC ATC TCG CAA GAA AAA TTT TAT AAG CTA 797Ala Ile Pro Val Phe Glu Gly Ile Ser Gln Glu Lys Phe Tyr Lys Leu
125 130 135TTT GAA TTA GCT AAG ATC GCT ATG GAT GGC AAA ATG GAT CTG TAT GAC 845Phe Glu Leu Ala Lys Ile Ala Met Asp Gly Lys Met Asp Leu Tyr Asp
140 145 150GGA CGC ACA GGC GAG AAA ATG AGG GAG CGC GTG AAT GTG GGC TAC ATG 893Gly Arg Thr Gly Glu Lys Met Arg Glu Arg Val Asn Val Gly Tyr Met
155 160 165TAT ATG ATC AAA CTC CAC CAT TTA GTG GAT GAA AAA GTC CAT GCC AGA 941Tyr Met Ile Lys Leu His His Leu Val Asp Glu Lys Val His Ala Arg170 175 180 185AGC ACA GGC CCT TAT AGC TTA GTA ACG CAC CAG CCC GTG GGG GGT AAA 989Ser Thr Gly Pro Tyr Ser Leu Val Thr His Gln Pro Val Gly Gly Lys
190 195 200GCG CTC TTT GGG GGT CAA AGG TTT GGG GAA ATG GAA GTG TGG GCC TTG 1037Ala Leu Phe Gly Gly Gln Arg Phe Gly Glu Met Glu Val Trp Ala Leu
205 210 215GAA GCT TAT GGC GCA GCG CAC ACT CTA AAA GAA ATG CTC ACC ATT AAA 1085Glu Ala Tyr Gly Ala Ala His Thr Leu Lys Glu Met Leu Thr Ile Lys
220 225 230TCC GAT GAT ATT AGA GGC AGA GAG AAC GCT TAT AGG GCT ATC GCT AAA 1133Ser Asp Asp Ile Arg Gly Arg Glu Asn Ala Tyr Arg Ala Ile Ala Lys
235 240 245GGT GAG CAA GTG GGC GAG AGT GAA ATC CCT GAG ACT TTC TAT GTT TTG 1181Gly Glu Gln Val Gly Glu Ser Glu Ile Pro Glu Thr Phe Tyr Val Leu250 255 260 265ACT AAA GAA TTG CAA TCG CTC GCT TTG GAT ATT AAT ATT TTT GGG GAC 1229Thr Lys Glu Leu Gln Ser Leu Ala Leu Asp Ile Asn Ile Phe Gly Asp
270 275 280GAT GTG GAT GAG GAT GGA GCA CCT AAA CCC ATT GTC ATT AAA GAA GAT 1277Asp Val Asp Glu Asp Gly Ala Pro Lys Pro Ile Val Ile Lys Glu Asp
285 290 295GAC AGG CCT AAA GAC TTT AGC TCT TTC CAG CTC ACA CTA GCT AGC CCT 1325Asp Arg Pro Lys Asp Phe Ser Ser Phe Gln Leu Thr Leu Ala Ser Pro
300 305 310GAA AAA ATC CAT TCT TGG AGT TAT GGG GAA GTT AAA AAG CCA GAA ACG 1373Glu Lys Ile His Ser Trp Ser Tyr Gly Glu Val Lys Lys Pro Glu Thr
315 320 325ATC AAT TAT CGC ACC CTA AAA CCT GAA CGA GAC GGC TTG TTT TGC ATG 1421Ile Asn Tyr Arg Thr Leu Lys Pro Glu Arg Asp Gly Leu Phe Cys Met330 335 340 345AAA ATC TTT GGC CCC ACT AAA GAT TAT GAA TGC TTG TGC GGC AAA TAC 1469Lys Ile Phe Gly Pro Thr Lys Asp Tyr Glu Cys Leu Cys Gly Lys Tyr
350 355 360AAA AAG CCT CGC TTC AAA GAC ATT GGC ACA TGC GAA AAA TGC GGC GTG 1517Lys Lys Pro Arg Phe Lys Asp Ile Gly Thr Cys Glu Lys Cys Gly Val
365 370 375GCG ATC ACG CAC TCC AAA GTC AGG CGT TTT AGA ATG GGG CAT ATT GAA 1565Ala Ile Thr His Ser Lys Val Arg Arg Phe Arg Met Gly His Ile Glu
380 385390TTG GCC ACT CCT GTA GCG CAT ATC TGG TAT GTT AAT TCC TTG CCT AGC 1613Leu Ala Thr Pro Val Ala His Ile Trp Tyr Val Asn Ser Leu Pro Ser
395 400 405CGT ATC GGC ACG CTT TTA GGC GTT AAG ATG AAA GAC TTA GAG CGC GTG 1661Arg Ile Gly Thr Leu Leu Gly Val Lys Met Lys Asp Leu Glu Arg Val410 415 420 425TTG TAT TAT GAA GCT TAT ATC GTT AAA GAA CCA GGC GAA GCC GCT TAT 1709Leu Tyr Tyr Glu Ala Tyr Ile Val Lys Glu Pro Gly Glu Ala Ala Tyr
430 435 440GAC AAT GAA GGC ACT AAG CTT GTG ATG AAA TAC GAT ATT TTG AAT GAA 1757Asp Asn Glu Gly Thr Lys Leu Val Met Lys Tyr Asp Ile Leu Asn Glu
445 450 455GAG CAG TAT CAA AAT ATC TCA CGA AGA TAC GAA GAC AGG GGC TTT GTA 1805Glu Gln Tyr Gln Asn Ile Ser Arg Arg Tyr Glu Asp Arg Gly Phe Val
460 465 470GCG CAA ATG GGC GGT GAA GCG ATC AAG GAT TTG TTA GAA GAA ATT GAT 1853Ala Gln Met Gly Gly Glu Ala Ile Lys Asp Leu Leu Glu Glu Ile Asp
475 480 485TTG ATC ACC TTA TTG CAG AGT TTG AAA GAA GAA GTG AAA GAC ACC AAT 1901Leu Ile Thr Leu Leu Gln Ser Leu Lys Glu Glu Val Lys Asp Thr Asn490 495 500 505TCT GAT GCG AAA AAG AAA AAA CTC ATT AAG CGT TTG AAA GTG GTA GAA 1949Ser Asp Ala Lys Lys Lys Lys Leu lle Lys Arg Leu Lys Val Val Glu
510 515 520AGC TTT TTA AAT TCT GGT AAT AGG CCT GAA TGG ATG ATG CTC ACG GTT 1997Ser Phe Leu Asn Ser Gly Asn Arg Pro Glu Trp Met Met Leu Thr Val
525 530 535TTA CCG GTA TTG CCA CCG GAT TTA AGG CCT TTA GTC GCG CTA GAT GGC 2045Leu Pro ValLeu Pro Pro Asp Leu Arg Pro Leu Val Ala Leu Asp Gly
540 545 550GGG AAG TTT GCA GTC AGC GAT GTG AAT GAA TTG TAT CGT CGT GTC ATC 2093Gly Lys Phe Ala Val Ser Asp Val Asn Glu Leu Tyr Arg Arg Val Ile
555 560 565AAT CGT AAC CAA CGC TTG AAA CGC TTA ATG GAG CTT GGA GCG CCA GAA 2141Asn Arg Asn Gln Arg Leu Lys Arg Leu Met Glu Leu Gly Ala Pro Glu570 575 580 585ATC ATT GTG CGC AAT GAA AAA AGG ATG TTG CAA GAA GCC GTG GAT GTG 2189Ile Ile Val Arg Asn Glu Lys Arg Met Leu Gln Glu Ala Val Asp Val
590 595 600CTT TTT GAT AAC GGC CGC AGC ACT AAT GCG GTT AAA GGG GCT AAC AAA 2237Leu Phe Asp Asn Gly Arg Ser Thr Asn Ala Val Lys Gly Ala Asn Lys
605 610 615CGC CCT TTA AAA TCG CTC AGT GAA ATC ATT AAA GGC AAG CAG GGG CGT 2285Arg Pro Leu Lys Ser Leu Ser Glu Ile Ile Lys Gly Lys Gln Gly Arg
620 625 630TTC AGG CAA AAC CTT TTA GGT AAG CGC GTG GAT TTT TCA GGC AGA AGC 2333Phe Arg Gln Asn Leu Leu Gly Lys Arg Val Asp Phe Ser Gly Arg Ser
635 640 645GTG ATT GTG GTT GGG CCT AAT CTC AAA ATG GAT GAA TGC GGG TTG CCT 2381Val Ile Val Val Gly Pro Asn Leu Lys Met Asp Glu Cys Gly Leu Pro650 655 660 665AAA AAC ATG GCG TTA GAA CTC TTC AAA CCG CAT TTG TTA TCC AAG CTT 2429Lys Asn Met Ala Leu Glu Leu Phe Lys Pro His Leu Leu Ser Lys Leu
670 675 680GAA GAG AGA GGC TAT GCC ACC ACG CTC AAA CAG GCT AAA CGC ATG ATT 2477Glu Glu Arg Gly Tyr Ala Thr Thr Leu Lys Gln Ala Lys Arg Met Ile
685 690695GAG CAA AAA AGC AAT GAA GTA TGG GAG TGC TTG CAA GAA ATC ACA GAG 2525Glu Gln Lys Ser Asn Glu Val Trp Glu Cys Leu Gln Glu Ile Thr Glu
700 705 710GGG TAT CCG GTG CTA CTC AAC CGC GCT CCT ACC TTG CAC AAG CAA TCC 2573Gly Tyr Pro Val Leu Leu Asn Arg Ala Pro Thr Leu His Lys Gln Ser
715 720 725ATT CAA GCG TTC CAT CCA AAG CTG ATT GAC GGC AAA GCG ATC CAA TTG 2621Ile Gln Ala Phe His Pro Lys Leu Ile Asp Gly Lys Ala Ile Gln Leu730 735 740 745CAC CCG TTA GTG TGT TCA GCG TTC AAC GCC GAT TTT GAC GGG GAC CAA 2669His Pro Leu Val Cys Ser Ala Phe Asn Ala Asp Phe Asp Gly Asp Gln
750 755 760ATG GCG GTG CAT GTG CCT TTA AGC CAG GAA GCG ATC GCT GAA TGC AAG 2717Met Ala Val His Val Pro Leu Ser Gln Glu Ala Ile Ala Glu Cys Lys
765 770 775GTG CTG ATG CTA AGC TCT ATG AAT ATC CTT TTG CCT GCT AGC GGT AAG 2765Val Leu Met Leu Ser Ser Met Asn Ile Leu Leu Pro Ala Ser Gly Lys
780 785 790GCC GTA GCC ATT CCT AGC CAA GAT ATG GTT TTA GGG CTT TAT TAT CTT 2813Ala Val Ala Ile Pro Ser Gln Asp Met Val Leu Gly Leu Tyr Tyr Leu
795 800 805TCT TTA GAA AAG AGC GGG GTC AAG GGC GAG CAT AAG CTT TTT TCT AGC 2861Ser Leu Glu Lys Ser Gly Val Lys Gly Glu His Lys Leu Phe Ser Ser810 815 820 825GTG AAT GAA ATC ATC ACC GCC ATT GAC ACG AAA GAA TTA GAC ATC CAC 2909Val Asn Glu Ile Ile Thr Ala Ile Asp Thr Lys Glu Leu Asp Ile His
830 835 840GCA AAG ATT AGG GTT TTA GAT CAA GGG AAT ATT ATC GCT ACG AGT GCA 2957Ala Lys IleArg Val Leu Asp Gln Gly Asn Ile Ile Ala Thr Ser Ala
845 850 855GGG CGC ATG ATC ATT AAG TCC ATT TTG CCT GAT TTT ATC CCT ACG GAT 3005Gly Arg Met Ile Ile Lys Ser Ile Leu Pro Asp Phe Ile Pro Thr Asp
860 865 870TTG TGG AAC AGA CCC ATG AAG AAA AAA GAT ATT GGC GTG CTT GTG GAT 3053Leu Trp Asn Arg Pro Met Lys Lys Lys Asp Ile Gly Val Leu Val Asp
875 880 885TAT GTG CAT AAA GTT GGC GGT ATC GGT ATT ACT GCA ACC TTT TTG GAT 3101Tyr Val His Lys Val Gly Gly Ile Gly Ile Thr Ala Thr Phe Leu Asp890 895 900 905AAT TTA AAA ACG CTT GGC TTT AGG TAT GCG ACT AAG GCT GGT ATT TCT 3149Asn Leu Lys Thr Leu Gly Phe Arg Tyr Ala Thr Lys Ala Gly Ile Ser
910 915 920ATC TCT ATG GAG GAT ATT ATC ACG CCA AAA GAC AAG CAA AAA ATG GTG 3197Ile Ser Met Glu Asp Ile Ile Thr Pro Lys Asp Lys Gln Lys Met Val
925 930 935GAA AAA GCC AAA GTA GAG GTT AAA AAA ATC CAG CAA CAA TAC GAT CAA 3245Glu Lys Ala Lys Val Glu Val Lys Lys Ile Gln Gln Gln Tyr Asp Gln
940 945 950GGG CTG CTC ACT GAC CAA GAG CGT TAC AAT AAG ATC ATT GAC ACT TGG 3293Gly Leu Leu Thr Asp Gln Glu Arg Tyr Asn Lys Ile Ile Asp Thr Trp
955 960 965ACT GAA GTC AAT GAC AAA ATG AGT AAA GAA ATG ATG ACC GCT ATC GCG 3341Thr Glu Val Asn Asp Lys Met Ser Lys Glu Met Met Thr Ala Ile Ala970 975 980 985CAA GAT AAA GAG GGC TTT AAC TCT ATT TAT ATG ATG GCA GAT AGC GGC 3389Gln Asp Lys Glu Gly Phe Asn Ser Ile Tyr Met Met Ala Asp Ser Gly
990995 1000GCA AGG GGT AGC GCG GCG CAA ATC CGT CAG CTT TCA GCG ATG AGG GGT 3437Ala Arg Gly Ser Ala Ala Gln Ile Arg Gln Leu Ser Ala Met Arg Gly
1005 1010 1015CTT ATG ACA AAG CCG GAC GGC AGT ATC ATT GAA ACG CCC ATT ATT TCT 3485Leu Met Thr Lys Pro Asp Gly Ser Ile Ile Glu Thr Pro Ile Ile Ser
1020 1025 1030AAC TTT AAA GAG GGG TTG AAT GTC TTA GAA TAC TTC AAT TCC ACG CAT 3533Asn Phe Lys Glu Gly Leu Asn Val Leu Glu Tyr Phe Asn Ser Thr His
1035 1040 1045GGC GCT AGA AAG GGC TTA GCG GAT ACA GCG CTA AAA ACA GCC AAT GCG 3581Gly Ala Arg Lys Gly Leu Ala Asp Thr Ala Leu Lys Thr Ala Asn Ala1050 1055 1060 1065GGG TAT TTG ACC AGA AAG CTC ATT GAT GTT TCG CAA AAT GTC AAG GTG 3629Gly Tyr Leu Thr Arg Lys Leu Ile Asp Val Ser Gln Asn Val Lys Val
1070 1075 1080GTG TCT GAT GAT TGC GGC ACG CAT GAA GGG ATT GAA ATC ACG GAT ATT 3677Val Ser Asp Asp Cys Gly Thr His Glu Gly Ile Glu Ile Thr Asp Ile
1085 1090 1095GCG GTG GGG AGT GAG CTG ATT GAA CCT TTA GAA GAG CGT ATT TTT GGG 3725Ala Val Gly Ser Glu Leu Ile Glu Pro Leu Glu Glu Arg Ile Phe Gly
1100 1105 1110CGC GTT TTA TTA GAA GAT GTG ATC GAT CCC ATT ACG AAT GAA ATC TTG 3773Arg Val Leu Leu Glu Asp Val Ile Asp Pro Ile Thr Asn Glu Ile Leu
1115 1120 1125CTT TAT GCG GAC ACT TTG ATT GAT GAA GAG GGT GCT AAA AAG GTG GTT 3821Leu Tyr Ala Asp Thr Leu Ile Asp Glu Glu Gly Ala Lys Lys Val Val1130 1135 1140 1145GAA GCC GGG ATT AAA TCC ATT ACG ATC CGC ACC CCA GTAACT TGT AAA 3869Glu Ala Gly Ile Lys Ser Ile Thr Ile Arg Thr Pro Val Thr Cys Lys
1150 1155 1160GCG CCA AAG GGC GTG TGC GCG AAA TGC TAT GGC TTG AAT TTG GGC GAA 3917Ala Pro Lys Gly Val Cys Ala Lys Cys Tyr Gly Leu Asn Leu Gly Glu
1165 1170 1175GGC AAG ATG AGT TAT CCG GGT GAA GCG GTG GGC GTG GTA GCC GCG CAA 3965Gly Lys Met Ser Tyr Pro Gly Glu Ala Val Gly Val Val Ala Ala Gln
1180 1185 1190TCT ATT GGG GAG CCT GGA ACG CAG CTC ACT TTA AGG ACT TTC CAT GTG 4013Ser Ile Gly Glu Pro Gly Thr Gln Leu Thr Leu Arg Thr Phe His Val
1195 1200 1205GGC GGG ACA GCG AGC AGG AGT CAG GAT GAG CGC GAA ATC GTA GCG AGC 4061Gly Gly Thr Ala Ser Arg Ser Gln Asp Glu Arg Glu Ile Val Ala Ser1210 1215 1220 1225AAA GAA GGT TTT GTG CGT TTT TAC AAC CTT AGG ACT TAC ACG AAT AAA 4109Lys Glu Gly Phe Val Arg Phe Tyr Asn Leu Arg Thr Tyr Thr Asn Lys
1230 1235 1240GAG GGT AAA AAC ATT ATC GCT AAC CGC CGT AAC GCT TCT ATT TTA GTG 4157Glu Gly Lys Asn Ile Ile Ala Asn Arg Arg Asn Ala Ser Ile Leu Val
1245 1250 1255GTA GAG CCT AAG ATT AAA GCG CCT TTT GAT GGG GAA TTA CGC ATT GAA 4205Val Glu Pro Lys Ile Lys Ala Pro Phe Asp Gly Glu Leu Arg Ile Glu
1260 1265 1270ACG GTT TAT GAA GAA GTC GTT GTG AGC GTG AAA AAT GGC GAT CAA GAA 4253Thr Val Tyr Glu Glu Val Val Val Ser Val Lys Asn Gly Asp Gln Glu
1275 1280 1285GCT AAA TTT GTT TTA AGG AGA AGC GAT ATT GTC AAG CCA AGC GAA TTA 4301Ala Lys Phe Val Leu Arg Arg Ser Asp Ile Val LysPro Ser Glu Leu1290 1295 1300 1305GCC GGC GTT GGC GGT AAG ATT GAG GGG AAA GTG TAT TTG CCT TAT GCT 4349Ala Gly Val Gly Gly Lys Ile Glu Gly Lys Val Tyr Leu Pro Tyr Ala
1310 1315 1320AGT GGG CAT AAG GTG CAT AAG GGG GGA AGT ATC GCT GAT ATT ATC CAA 4397Ser Gly His Lys Val His Lys Gly Gly Ser Ile Ala Asp Ile Ile Gln
1325 1330 1335GAG GGC TGG AAT GTG CCT AAT CGC ATC CCT TAT GCG AGC GAA TTG CTA 4445Glu Gly Trp Asn Val Pro Asn Arg Ile Pro Tyr Ala Ser Glu Leu Leu
1340 1345 1350GTC AAG GAT AAT GAC CCT ATT GCG CAA GAT GTG TAT GCC AAA GAA AAA 4493Val Lys Asp Asn Asp Pro Ile Ala Gln Asp Val Tyr Ala Lys Glu Lys
1355 1360 1365GGC GTA ATC AAA TAC TAT GTT TTA GAG GCT AAC CAT TTA GAG CGC ACC 4541Gly Val Ile Lys Tyr Tyr Val Leu Glu Ala Asn His Leu Glu Arg Thr1370 1375 1380 1385CAT GGG ATC AAA AAG GGC GAT ATG GTG AGT GAA AAA GGC TTG TTT GCG 4589His Gly Ile Lys Lys Gly Asp Met Val Ser Glu Lys Gly Leu Phe Ala
1390 1395 1400GTG ATA GCT GAT GAT AAT GGT AGG GAA GCC GCT CGC CAT TAT ATC GCT 4637Val Ile Ala Asp Asp Asn Gly Arg Glu Ala Ala Arg His Tyr Ile Ala
1405 1410 1415AGG GGT TCT GAG ATC TTG ATT GAT GAT AAT AGT GAA GTG AGC ACT AAT 4685Arg Gly Ser Glu Ile Leu Ile Asp Asp Asn Ser Glu Val Ser Thr Asn
1420 1425 1430AGC GTG ATT TCT AAA CCC ACG ACT AAC ACT TTC AAA ACG ATT GCC ACA 4733Ser Val Ile Ser Lys Pro Thr Thr Asn Thr Phe Lys Thr Ile Ala Thr
1435 14401445TGG GAT CCT TAC AAC ACC CCT ATC ATT GCG GAC TTT AAA GGT AAG GTG 4781Trp Asp Pro Tyr Asn Thr Pro Ile Ile Ala Asp Phe Lys Gly Lys Val1450 1455 1460 1465GGT TTT GTG GAT GTT ATC GCA GGG GTT ACG GTC GCT GAA AAA GAA GAC 4829Gly Phe Val Asp Val Ile Ala Gly Val Thr Val Ala Glu Lys Glu Asp
1470 1475 1480GAA AAT ACC GGT ATC ACA AGC TTA GTG GTG AAT GAT TAC ATT CCA AGC 4877Glu Asn Thr Gly Ile Thr Ser Leu Val Val Asn Asp Tyr Ile Pro Ser
1485 1490 1495GGA TAC AAA CCA AGC TTG TTT TTA GAG GGG GCT AAT GGC GAA GAG ATG 4925Gly Tyr Lys Pro Ser Leu Phe Leu Glu Gly Ala Asn Gly Glu Glu Met
1500 1505 1510CGT TAT TTC CTA GAG CCA AAA ACC TCT ATC GCC ATT AGC GAT GGC TCT 4973Arg Tyr Phe Leu Glu Pro Lys Thr Ser Ile Ala Ile Ser Asp Gly Ser
1515 1520 1525AGC GTG GAG CAA GCT GAA GTG TTA GCG AAA ATC CCT AAA GCG ACC GTT 5021Ser Val Glu Gln Ala Glu Val Leu Ala Lys Ile Pro Lys Ala Thr Val1530 1535 1540 1545AAA TCT AGG GAT ATT ACC GGG GGT CTC CCA AGG GTT TCG GAA CTC TTT 5069Lys Ser Arg Asp Ile Thr Gly Gly Leu Pro Arg Val Ser Glu Leu Phe
1550 1555 1560GAA GCG AGA AAA CCC AAG CCT AAA GAT GTG GCG ATC CTT TCT GAA GTT 5117Glu Ala Arg Lys Pro Lys Pro Lys Asp Val Ala Ile Leu Ser Glu Val
1565 1570 1575GAT GGG ATT GTG AGT TTT GGC AAA CCC ATT CGC AAT AAA GAA CAC ATC 5165Asp Gly Ile Val Ser Phe Gly Lys Pro Ile Arg Asn Lys Glu His Ile
1580 1585 1590ATC GTA ACT TCT AAA GAT GGC CGT TCC ATG GAT TAT TTT GTG GAT AAA5213Ile Val Thr Ser Lys Asp Gly Arg Ser Met Asp Tyr Phe Val Asp Lys
1595 1600 1605GGC AAG CAA ATT TTA GTG CAT GCC GAT GAA TTT GTG CAT GCG GGA GAA 5261Gly Lys Gln Ile Leu Val His Ala Asp Glu Phe Val His Ala Gly Glu1610 1615 1620 1625GCG ATG ACG GAC GGA GTA ATT TCA AGC CAT GAT ATT TTA AGG ATC AGT 5309Ala Met Thr Asp Gly Val Ile Ser Ser His Asp Ile Leu Arg Ile Ser
1630 1635 1640GGC GAA AAA GAG CTT TAT AAA TAC ATT GTG AGC GAA GTC CAG CAA GTG 5357Gly Glu Lys Glu Leu Tyr Lys Tyr Ile Val Ser Glu Val Gln Gln Val
1645 1650 1655TAT CGC AGG CAG GGG GTG AGC ATT GCG GAC AAG CAC ATT GAA ATC ATT 5405Tyr Arg Arg Gln Gly Val Ser Ile Ala Asp Lys His Ile Glu Ile Ile
1660 1665 1670GTT TCT CAA ATG CTA AGA CAG GTG CGT ATT TTA GAC AGC GGG GAT AGC 5453Val Ser Gln Met Leu Arg Gln Val Arg Ile Leu Asp Ser Gly Asp Ser
1675 1680 1685AAG TTT ATT GAA GGG GAT TTA GTC AGT AAA AAA CTT TTC AAA GAA GAA 5501Lys Phe Ile Glu Gly Asp Leu Val Ser Lys Lys Leu Phe Lys Glu Glu1690 1695 1700 1705AAC GCT CGT GTG ATC GCT TTA AAA GGC GAG CCA GCG ATT GCT GAA CCG 5549Asn Ala Arg Val Ile Ala Leu Lys Gly Glu Pro Ala Ile Ala Glu Pro
1710 1715 1720GTG CTT TTA GGG ATC ACT AGA GCG GCT ATT GGG AGC GAT AGC ATC ATC 5597Val Leu Leu Gly Ile Thr Arg Ala Ala Ile Gly Ser Asp Ser Ile Ile
1725 1730 1735TCA GCG GCC TCT TTC CAA GAA ACG ACT AAA GTT TTA ACA GAA GCC AGT 5645Ser Ala Ala Ser Phe Gln Glu Thr Thr Lys Val Leu Thr Glu Ala Sar
17401745 1750ATC GCT ATG AAA AAA GAC TTT TTA GAG GAT TTG AAA GAG AAT GTG GTG 5693Ile Ala Met Lys Lys Asp Phe Leu Glu Asp Leu Lys Glu Asn Val Val
1755 1760 1765TTG GGG AGG ATG ATC CCT GTG GGA ACA GGC ATG TAT AAG AAT AAA AAA 5741Leu Gly Arg Met Ile Pro Val Gly Thr Gly Met Tyr Lys Asn Lys Lys1770 1775 1780 1785ATC GTG TTA AGA GCG CTT GAG GAT AAC TCT AAA TTT TGATATGAAA AATCGG 5793Ile Val Leu Arg Ala Leu Glu Asp Asn Ser Lys Phe
1790 1795TTAAGATTTT TAAAAGAAAA ATTAGGGTAA AATGGGGGA 5832
(2) Sequence 308 data:
(i) sequence characteristics:
(A) length: 1797 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 308: met Ala Gly Arg His Gly Asn Lys Gly Ile Val Ser Asn Ile Val Pro 151015 Val Ala Asp Met Pro Tyr Thr Ala Asp Gly Glu Pro Val Asp Ile Val
20 25 30Leu Asn Pro Leu Gly Val Pro Ser Arg Met Asn Ile Gly Gln Ile Leu
35 40 45Glu Met His Leu Gly Leu Val Gly Lys Glu Phe Gly Lys Gln Ile Ala
50 55 60Arg Met Leu Glu Asp Lys Thr Lys Asp Phe Ala Lys Glu Leu Arg Ala65 70 75 80Lys Met Leu Glu Xaa Ala Asn Ala Ile Asn Glu Lys Asp Pro Leu Thr
85 90 95Ile His Ala Leu Glu Asn Cys Ser Asp Glu Glu Leu Leu Glu Tyr Ala
100 105 110Lys Asp Trp Ser Lys Gly Val Lys Met Ala Ile Pro Val Phe Glu Gly
115 120 125Ile Ser Gln Glu Lys Phe Tyr Lys Leu Phe Glu Leu Ala Lys Ile Ala
130 135 140Met Asp Gly Lys Met Asp Leu Tyr Asp Gly Arg Thr Gly Glu Lys Met145 150 155 160Arg Glu Arg Val Asn Val Gly Tyr Met Tyr Met Ile Lys Leu His His
165 170 175Leu Val Asp Glu Lys Val His Ala Arg Ser Thr Gly Pro Tyr Ser Leu
180 185 190Val Thr His Gln Pro Val Gly Gly Lys Ala Leu Phe Gly Gly Gln Arg
195 200 205Phe Gly Glu Met Glu Val Trp Ala Leu Glu Ala Tyr Gly Ala Ala His
210 215 220Thr Leu Lys Glu Met Leu Thr Ile Lys Ser Asp Asp Ile Arg Gly Arg225 230 235 240Glu Asn Ala Tyr Arg Ala Ile Ala Lys Gly Glu Gln Val Gly Glu Ser
245 250 255Glu Ile Pro Glu Thr Phe Tyr Val Leu Thr Lys Glu Leu Gln Ser Leu
260 265 270Ala Leu Asp Ile Asn Ile Phe Gly Asp Asp Val Asp Glu Asp Gly Ala
275 280 285Pro Lys Pro Ile Val Ile Lys Glu Asp Asp Arg Pro Lys Asp Phe Ser
290 295 300Ser Phe Gln Leu Thr Leu Ala Ser Pro Glu Lys Ile His Ser Trp Ser305310 315 320Tyr Gly Glu Val Lys Lys Pro Glu Thr Ile Asn Tyr Arg Thr Leu Lys
325 330 335Pro Glu Arg Asp Gly Leu Phe Cys Met Lys Ile Phe Gly Pro Thr Lys
340 345 350Asp Tyr Glu Cys Leu Cys Gly Lys Tyr Lys Lys Pro Arg Phe Lys Asp
355 360 365Ile Gly Thr Cys Glu Lys Cys Gly Val Ala Ile Thr His Ser Lys Val
370 375 380Arg Arg Phe Arg Met Gly His Ile Glu Leu Ala Thr Pro Val Ala His385 390 395 400Ile Trp Tyr Val Asn Ser Leu Pro Ser Arg Ile Gly Thr Leu Leu Gly
405 410 415Val Lys Met Lys Asp Leu Glu Arg Val Leu Tyr Tyr Glu Ala Tyr Ile
420 425 430Val Lys Glu Pro Gly Glu Ala Ala Tyr Asp Asn Glu Gly Thr Lys Leu
435 440 445Val Met Lys Tyr Asp Ile Leu Asn Glu Glu Gln Tyr Gln Asn Ile Ser
450 455 460Arg Arg Tyr Glu Asp Arg Gly Phe Val Ala Gln Met Gly Gly Glu Ala465 470 475 480Ile Lys Asp Leu Leu Glu Glu Ile Asp Leu Ile Thr Leu Leu Gln Ser
485 490 495Leu Lys Glu Glu Val Lys Asp Thr Asn Ser Asp Ala Lys Lys Lys Lys
500 505 510Leu Ile Lys Arg Leu Lys Val Val Glu Ser Phe Leu Asn Ser Gly Asn
515 520 525Arg Pro Glu Trp Met Met Leu Thr Val Leu Pro Val Leu Pro Pro Asp
530 535 540Leu Arg Pro Leu Val Ala Leu Asp Gly Gly Lys Phe Ala Val Ser Asp545 550 555 560Val Asn Glu Leu Tyr Arg Arg Val Ile Asn Arg Asn Gln Arg Leu Lys
565 570 575Arg Leu Met Glu Leu Gly Ala Pro Glu Ile Ile Val Arg Asn Glu Lys
580 585 590Arg Met Leu Gln Glu Ala Val Asp Val Leu Phe Asp Asn Gly Arg Ser
595 600 605Thr Asn Ala Val Lys Gly Ala Asn Lys Arg Pro Leu Lys Ser Leu Ser
610 615 620Glu Ile Ile Lys Gly Lys Gln Gly Arg Phe Arg Gln Asn Leu Leu Gly625 630 635 640Lys Arg Val Asp Phe Ser Gly Arg Ser Val Ile Val Val Gly Pro Asn
645 650 655Leu Lys Met Asp Glu Cys Gly Leu Pro Lys Asn Met Ala Leu Glu Leu
660 665 670Phe Lys Pro His Leu Leu Ser Lys Leu Glu Glu Arg Gly Tyr Ala Thr
675 680 685Thr Leu Lys Gln Ala Lys Arg Met Ile Glu Gln Lys Ser Asn Glu Val
690 695 700Trp Glu Cys Leu Gln Glu Ile Thr Glu Gly Tyr Pro Val Leu Leu Asn705 710 715 720Arg Ala Pro Thr Leu His Lys Gln Ser Ile Gln Ala Phe His Pro Lys
725 730 735Leu Ile Asp Gly Lys Ala Ile Gln Leu His Pro Leu Val Cys Ser Ala
740 745 750Phe Asn Ala Asp Phe Asp Gly Asp Gln Met Ala Val His Val Pro Leu
755 760765Ser Gln Glu Ala Ile Ala Glu Cys Lys Val Leu Met Leu Ser Ser Met
770 775 780Asn Ile Leu Leu Pro Ala Ser Gly Lys Ala Val Ala Ile Pro Ser Gln785 790 795 800Asp Met Val Leu Gly Leu Tyr Tyr Leu Ser Leu Glu Lys Ser Gly Val
805 810 815Lys Gly Glu His Lys Leu Phe Ser Ser Val Asn Glu Ile Ile Thr Ala
820 825 830Ile Asp Thr Lys Glu Leu Asp Ile His Ala Lys Ile Arg Val Leu Asp
835 840 845Gln Gly Asn Ile Ile Ala Thr Ser Ala Gly Arg Met Ile Ile Lys Ser
850 855 860Ile Leu Pro Asp Phe Ile Pro Thr Asp Leu Trp Asn Arg Pro Met Lys865 870 875 880Lys Lys Asp Ile Gly Val Leu Val Asp Tyr Val His Lys Val Gly Gly
885 890 895Ile Gly Ile Thr Ala Thr Phe Leu Asp Asn Leu Lys Thr Leu Gly Phe
900 905 910Arg Tyr Ala Thr Lys Ala Gly Ile Ser Ile Ser Met Glu Asp Ile Ile
915 920 925Thr Pro Lys Asp Lys Gln Lys Met Val Glu Lys Ala Lys Val Glu Val
930 935 940Lys Lys Ile Gln Gln Gln Tyr Asp Gln Gly Leu Leu Thr Asp Gln Glu945 950 955 960Arg Tyr Asn Lys Ile Ile Asp Thr Trp Thr Glu Val Asn Asp Lys Met
965 970 975Ser Lys Glu Met Met Thr Ala Ile Ala Gln Asp Lys Glu Gly Phe Asn
980 985990Ser Ile Tyr Met Met Ala Asp Ser Gly Ala Arg Gly Ser Ala Ala Gln
995 1000 1005Ile Arg Gln Leu Ser Ala Met Arg Gly Leu Met Thr Lys Pro Asp Gly 1010 1015 1020Ser Ile Ile Glu Thr Pro Ile Ile Ser Asn Phe Lys Glu Gly Leu Asn025 1030 1035 1040Val Leu Glu Tyr Phe Asn Ser Thr His Gly Ala Arg Lys Gly Leu Ala
1045 1050 1055Asp Thr Ala Leu Lys Thr Ala Asn Ala Gly Tyr Leu Thr Arg Lys Leu
1060 1065 1070Ile Asp Val Ser Gln Asn Val Lys Val Val Ser Asp Asp Cys Gly Thr
1075 1080 1085His Glu Gly Ile Glu Ile Thr Asp Ile Ala Val Gly Ser Glu Leu Ile 1090 1095 1100Glu Pro Leu Glu Glu Arg Ile Phe Gly Arg Val Leu Leu Glu Asp Val05 1110 1115 1120Ile Asp Pro Ile Thr Asn Glu Ile Leu Leu Tyr Ala Asp Thr Leu Ile
1125 1130 1135Asp Glu Glu Gly Ala Lys Lys Val Val Glu Ala Gly Ile Lys Ser Ile
1140 1145 1150Thr Ile Arg Thr Pro Val Thr Cys Lys Ala Pro Lys Gly Val Cys Ala
1155 1160 1165Lys Cys Tyr Gly Leu Asn Leu Gly Glu Gly Lys Met Ser Tyr Pro Gly1170 1175 1180Glu Ala Val Gly Val Val Ala Ala Gln Ser Ile Gly Glu Pro Gly Thr185 1190 1195 1200Gln Leu Thr Leu Arg Thr Phe His Val Gly Gly Thr Ala Ser Arg Ser
1205 1210 1215Gln Asp Glu Arg Glu Ile Val Ala Ser Lys Glu Gly Phe Val Arg Phe
1220 1225 1230Tyr Asn Leu Arg Thr Tyr Thr Asn Lys Glu Gly Lys Asn Ile Ile Ala
1235 1240 1245Asn Arg Arg Asn Ala Ser Ile Leu Val Val Glu Pro Lys Ile Lys Ala 1250 1255 1260Pro Phe Asp Gly Glu Leu Arg Ile Glu Thr Val Tyr Glu Glu Val Val265 1270 1275 1280Val Ser Val Lys Asn Gly Asp Gln Glu Ala Lys Phe Val Leu Arg Arg
1285 1290 1295Ser Asp Ile Val Lys Pro Ser Glu Leu Ala Gly Val Gly Gly Lys Ile
1300 1305 1310Glu Gly Lys Val Tyr Leu Pro Tyr Ala Ser Gly His Lys Val His Lys
1315 1320 1325Gly Gly Ser Ile Ala Asp Ile Ile Gln Glu Gly Trp Asn Val Pro Asn 1330 1335 1340Arg Ile Pro Tyr Ala Ser Glu Leu Leu Val Lys Asp Asn Asp Pro Ile345 1350 1355 1360Ala Gln Asp Val Tyr Ala Lys Glu Lys Gly Val Ile Lys Tyr Tyr Val
1365 1370 1375Leu Glu Ala Asn His Leu Glu Arg Thr His Gly Ile Lys Lys Gly Asp
1380 1385 1390Met Val Ser Glu Lys Gly Leu Phe Ala Val Ile Ala Asp Asp Asn Gly
1395 1400 1405Arg Glu Ala Ala Arg His Tyr Ile Ala Arg Gly Ser Glu Ile Leu Ile 1410 1415 1420Asp Asp Asn Ser Glu Val Ser Thr Asn Ser Val Ile Ser Lys Pro Thr425 1430 1435 1440Thr Asn Thr Phe Lys Thr Ile Ala Thr Trp Asp Pro Tyr Asn Thr Pro
1445 1450 1455Ile Ile Ala Asp Phe Lys Gly Lys Val Gly Phe Val Asp Val Ile Ala
1460 1465 1470Gly Val Thr Val Ala Glu Lys Glu Asp Glu Asn Thr Gly Ile Thr Ser
1475 1480 1485Leu Val Val Asn Asp Tyr Ile Pro Ser Gly Tyr Lys Pro Ser Leu Phe 1490 1495 1500Leu Glu Gly Ala Asn Gly Glu Glu Met Arg Tyr Phe Leu Glu Pro Lys505 1510 1515 1520Thr Ser Ile Ala Ile Ser Asp Gly Ser Ser Val Glu Gln Ala Glu Val
1525 1530 1535Leu Ala Lys Ile Pro Lys Ala Thr Val Lys Ser Arg Asp Ile Thr Gly
1540 1545 1550Gly Leu Pro Arg Val Ser Glu Leu Phe Glu Ala Arg Lys Pro Lys Pro
1555 1560 1565Lys Asp Val Ala Ile Leu Ser Glu Val Asp Gly Ile Val Ser Phe Gly 1570 1575 1580Lys Pro Ile Arg Asn Lys Glu His Ile Ile Val Thr Ser Lys Asp Gly585 1590 1595 1600Arg Ser Met Asp Tyr Phe Val Asp Lys Gly Lys Gln Ile Leu Val His
1605 1610 1615Ala Asp Glu Phe Val His Ala Gly Glu Ala Met Thr Asp Gly Val Ile
1620 1625 1630Ser Ser His Asp Ile Leu Arg Ile Ser Gly Glu Lys Glu Leu Tyr Lys
1635 1640 1645Tyr Ile Val Ser Glu Val Gln Gln ValTyr Arg Arg Gln Gly Val Ser 1650 1655 1660Ile Ala Asp Lys His Ile Glu Ile Ile Val Ser Gln Met Leu Arg Gln665 1670 1675 1680Val Arg Ile Leu Asp Ser Gly Asp Ser Lys Phe Ile Glu Gly Asp Leu
1685 1690 1695Val Ser Lys Lys Leu Phe Lys Glu Glu Asn Ala Arg ValIle Ala Leu
1700 1705 1710Lys Gly Glu Pro Ala Ile Ala Glu Pro Val Leu Leu Gly Ile Thr Arg
1715 1720 1725Ala Ala Ile Gly Ser Asp Ser Ile Ile Ser Ala Ala Ser Phe Gln Glu 1730 1735 1740Thr Thr Lys Val Leu Thr Glu Ala Ser Ile Ala Met Lys Lys Asp Phe745 1750 1755 1760Leu Glu Asp Leu Lys Glu Asn Val Val Leu Gly Arg Met Ile Pro Val
1765 1770 1775Gly Thr Gly Met Tyr Lys Asn Lys Lys Ile Val Leu Arg Ala Leu Glu
1780 1785 1790Asp Asn Ser Lys Phe
1795
(2) Sequence 309 data:
(i) sequence characteristics:
(A) length: 690bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 65...640
(D) Other information:
(xi) Description of the sequence: sequence 309: TAAGCGATTT GCTCTGTGTG GTGATTGACC CTAGGATTGA TTTTGAAAAG CGTTGAGGGT 60AGGA ATG AAA ACT GAG ATG AAA TCT TCT TTA AAA CTT TTT ATG CGG CCT 109
Met Lys Thr Glu Met Lys Ser Ser Leu Lys Leu Phe Met Arg Pro
1 5 10 15TTG TTG GTG GTT TTA GCG TTC ATG TTG TTG TAT GCT TTA GTG CAT GCT157Leu Leu Val Val Leu Ala Phe Met Leu Leu Tyr Ala Leu Val His Ala
20 25 30GCG CTT GGT TTT TAT GTA AAA AAA GAC AGC GCT CCA ATA AGC CCA AAT 205Ala Leu Gly Phe Tyr Val Lys Lys Asp Ser Ala Pro Ile Ser Pro Asn
35 40 45GTA GAA AAA ACC GAG ACA GAG CGT CAA AAC GGC GTG CTT TCG CCC AAA 253Val Glu Lys Thr Glu Thr Glu Arg Gln Asn Gly Val Leu Ser Pro Lys
50 55 60CAA GAA GAA GCC AAC GCA ACC ACA ACT GCC ACA GAA GAA AGC CCC ACC 301Gln Glu Glu Ala Asn Ala Thr Thr Thr Ala Thr Glu Glu Ser Pro Thr
65 70 75AAA GAC ACA GCG CCG CCT TTA GAC ACA GCC GCG CAA AAA CAA GAA ACT 349Lys Asp Thr Ala Pro Pro Leu Asp Thr Ala Ala Gln Lys Gln Glu Thr80 85 90 95AAA CAA GAG CAA GAA AAA GAA AAC GAG CCT AAA CAA GAT AGC GTC CCG 397Lys Gln Glu Gln Glu Lys Glu Asn Glu Pro Lys Gln Asp Ser Val Pro
100 105 110CCC GTT CAA AAC AAT CAA AAA ACC CCT ACA ACC CCC TTA ATG GGA AAA 445Pro Val Gln Asn Asn Gln Lys Thr Pro Thr Thr Pro Leu Met Gly Lys
115 120 125AAA CCT TTA GAG TAT AAA GTC GCA GTC AGT GGC GTG AAT GTG CGC GCT 493Lys Pro Leu Glu Tyr Lys Val Ala Val Ser Gly Val Asn Val Arg Ala
130 135 140TTT CCC AGC ACA AAA GGT AAA ATC TTG GGA TTG CTT TTA AAA AAT AAA 541Phe Pro Ser Thr Lys Gly Lys Ile Leu Gly Leu Leu Leu Lys Asn Lys
145 150 155AGC GTG AAA GTT TTA GAA ATC CAA AAC GAT TGG GCT GAA ATT GAA TTT 589Ser Val Lys Val Leu Glu Ile Gln Asn Asp Trp Ala Glu Ile Glu Phe160165 170 175TCT CAC GAA ACA AAG GGC TAT GTG TTT TTA AAA CTT TTA AAA AAG GCT 637Ser His Glu Thr Lys Gly Tyr Val Phe Leu Lys Leu Leu Lys Lys Ala
180 185 190GAA TGAAAGAATA ATGAAATTAA AATCTTTTGG GGTTTTTGGA AATCCCATTA 690Glu
(2) Sequence 310 data:
(i) sequence characteristics:
(A) length: 192 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 310: met Lys Thr Glu Met Lys Ser Ser Leu Lys Leu Phe Met Arg Pro Leu 151015 Leu Val Val Leu Ala Phe Met Leu Leu Tyr Ala Leu Val His Ala Ala
20 25 30Leu Gly Phe Tyr Val Lys Lys Asp Ser Ala Pro Ile Ser Pro Asn Val
35 40 45Glu Lys Thr Glu Thr Glu Arg Gln Asn Gly Val Leu Ser Pro Lys Gln
50 55 60Glu Glu Ala Asn Ala Thr Thr Thr Ala Thr Glu Glu Ser Pro Thr Lys65 70 75 80Asp Thr Ala Pro Pro Leu Asp Thr Ala Ala Gln Lys Gln Glu Thr Lys
85 90 95Gln Glu Gln Glu Lys Glu Asn Glu Pro Lys Gln Asp Ser Val Pro Pro
100 105 110Val Gln Asn Asn Gln Lys Thr Pro Thr Thr Pro Leu Met Gly Lys Lys
115 120 125Pro LeuGlu Tyr Lys Val Ala Val Ser Gly Val Asn Val Arg Ala Phe
130 135 140Pro Ser Thr Lys Gly Lys Ile Leu Gly Leu Leu Leu Lys Asn Lys Ser145 150 155 160Val Lys Val Leu Glu Ile Gln Asn Asp Trp Ala Glu Ile Glu Phe Ser
165 170 175His Glu Thr Lys Gly Tyr Val Phe Leu Lys Leu Leu Lys Lys Ala Glu
180 185 190
(2) Sequence 311 data:
(i) sequence characteristics:
(A) length: 1550bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 66...1502
(D) Other information:
(xi) Description of the sequence: sequence 311: TTATGACTTT TACTAAACCT TTTTTTAAGC TATAATCCAA AAATCTAAAA TAAAAAGGAA 60TAAGC ATG AAA AAA TCC CTT TGT CTG TCT TTC TTT CTG ACT TTC TCT AAC 110
Met Lys Lys Ser Leu Cys Leu Ser Phe Phe Leu Thr Phe Ser Asn
1 5 10 15CCT CTT CAA GCC CTT GTG ATC GAG CTT TTA GAA GAA ATC AAA ACT TCG 158Pro Leu Gln Ala Leu Val Ile Glu Leu Leu Glu Glu Ile Lys Thr Ser
20 25 30CCG CAT AAA GGC ACT TTT AAG GCT AAA GTC CTT GAT TCT AAA AAA CCA 206Pro His Lys Gly Thr Phe Lys Ala Lys Val Leu Asp Ser Lys LysPro
35 40 45AGA CAA GTT TTA GGC GTT TAT AAT ATC TCC CCA CAC AAA AAA CTC ACG 254Arg Gln Val Leu Gly Val Tyr Asn Ile Ser Pro His Lys Lys Leu Thr
50 55 60CTC ACT ATC ACC CAC ATA TCC ACT GCA ATC GTC TAT CAA CCC CTT GAT 302Leu Thr Ile Thr His Ile Ser Thr Ala Ile Val Tyr Gln Pro Leu Asp
65 70 75GAA AAA CTT TCT TTA GAA ACA ACC TTA AAC CCT AAC CGC CCT ACT ATC 350Glu Lys Leu Ser Leu Glu Thr Thr Leu Asn Pro Asn Arg Pro Thr Ile80 85 90 95CCT AGA AAC ACC CAG ATT GTT TTT TCT TCA AAA GAA TTG AAA GAG TCG 398Pro Arg Asn Thr Gln Ile Val Phe Ser Ser Lys Glu Leu Lys Glu Ser
100 105 110CAC CCG CAC CAA ATG CCT TCT TTA AAC GCG CCC ATG CAA AAA CCA CAA 446His Pro His Gln Met Pro Ser Leu Asn Ala Pro Met Gln Lys Pro Gln
115 120 125AAC AAA CCC CAT TCA TCG CAA CAA CCT TCT CAA AAC TTT TCT TAC CCA 494Asn Lys Pro His Ser Ser Gln Gln Pro Ser Gln Asn Phe Ser Tyr Pro
130 135 140GAG CCC AAA CTA GGC TCT AAA AAC TCT AAA AAC AGC CTT TTA CAG CCT 542Glu Pro Lys Leu Gly Ser Lys Asn Ser Lys Asn Ser Leu Leu Gln Pro
145 150 155TTA GCA ATT CCT AGC AAA ATA AGT CCC ACT AAC GAA ACT CAA ACG CCA 590Leu Ala Ile Pro Ser Lys Ile Ser Pro Thr Asn Glu Thr Gln Thr Pro160 165 170 175ACA AAC GAC ACT AAA CCC CCT TTA AAG CAT TCT TCA GAA GAT CAA GAA 638Thr Asn Asp Thr Lys Pro Pro Leu Lys His Ser Ser Glu Asp Gln Glu
180 185 190AGC AAC CTC TTT ATA ACG CCA CCC ACT GAA AAA ACG CTC CCT AAC AAC 686Ser Asn Leu Phe Ile Thr Pro Pro Thr Glu Lys Thr Leu Pro Asn Asn
195 200 205ACC TCT AAC GCT GAT ATT AGT GAA AAC AAT GAA AGC AAT GAG AAT AAA 734Thr Ser Asn Ala Asp Ile Ser Glu Asn Asn Glu Ser Asn Glu Asn Lys
210 215 220GAT AAT GTG GAA AAA CAA GCC ATT AGA GAT GCT AAT ATT AAA GAA TTT 782Asp Asn Val Glu Lys Gln Ala Ile Arg Asp Ala Asn Ile Lys Glu Phe
225 230 235GCA TGC GGG AAG TGG GTC TAT GAC GAT GAA AAT TTA CAA GCC TAC CGC 830Ala Cys Gly Lys Trp Val Tyr Asp Asp Glu Asn Leu Gln Ala Tyr Arg240 245 250 255CCA AGC ATT TTA AAA CGC GTT GAT GAA GAC AAA CAA ACT GCA ACA GAT 878Pro Ser Ile Leu Lys Arg Val Asp Glu Asp Lys Gln Thr Ala Thr Asp
260 265 270ATT ACC CCT TGC GAT TAC AGC ACC GCT GAA AAT AAA AGC GGT AAA ATC 926Ile Thr Pro Cys Asp Tyr Ser Thr Ala Glu Asn Lys Ser Gly Lys Ile
275 280 285ATT ACC CCC TAT ACT AAA ATC TCC GTT CAT AAA ACA GAG CCT TTA GAA 974Ile Thr Pro Tyr Thr Lys Ile Ser Val His Lys Thr Glu Pro Leu Glu
290 295 300GAG CCA CAA ACT TTT GAA GCT AAA AAT AAT TTC GCC ATT CTT CAA GCC 1022Glu Pro Gln Thr Phe Glu Ala Lys Asn Asn Phe Ala Ile Leu Gln Ala
305 310 315AGA AGC TCT ACA GAA AAA TGC AAA AGG GCT AGA GCA AGA AAA GAC GGC 1070Arg Ser Ser Thr Glu Lys Cys Lys Arg Ala Arg Ala Arg Lys Asp Gly320 325 330 335ACG ACT AGG CAA TGC TAT CTA ATA GAA GAG CCT TTA AAA CAA GCA TGG 1118Thr Thr Arg Gln Cys Tyr Leu Ile Glu Glu Pro Leu Lys Gln Ala Trp
340 345 350GAG AGT GAG TAT GAA ATC ACC ACG CAA TTA GTG AAA GCC ATT TAT GAG 1166Glu Ser Glu Tyr Glu Ile Thr Thr Gln Leu Val Lys Ala Ile Tyr Glu
355 360 365CGC CCC AAA CAA GAC GAT CAA GTA GAG CCG ACT TTT TAT GAA ACC AGC 1214Arg Pro Lys Gln Asp Asp Gln Val Glu Pro Thr Phe Tyr Glu Thr Ser
370 375 380GAA TTG GCT TAT TCT TCC ACA CGA AAA AGC GAA ATA ACG CAC AAT GAA 1262Glu Leu Ala Tyr Ser Ser Thr Arg Lys Ser Glu Ile Thr His Asn Glu
385 390 395TTG AAT TTG AAT GAA AAA TTC ATG GAA TTT GTG GAA GTG TAT GAG GGG 1310Leu Asn Leu Asn Glu Lys Phe Met Glu Phe Val Glu Val Tyr Glu Gly400 405 410 415CAT TAT TTA AAC GAT ATA ATT AAA GAG AGC AGT GAA TAT AAA GAA TGG 1358His Tyr Leu Asn Asp Ile Ile Lys Glu Ser Ser Glu Tyr Lys Glu Trp
420 425 430GTT AAA AAC CAT GTG CGC TTT AAA GAA GGG GTG TGC ATG GCT TTA GAA 1406Val Lys Asn His Val Arg Phe Lys Glu Gly Val Cys Met Ala Leu Glu
435 440 445ATA GAA GAA CAG CCA CGA GCT AAA AGC ACG CCT TTG AGT ATT GAA AAC 1454Ile Glu Glu Gln Pro Arg Ala Lys Ser Thr Pro Leu Ser Ile Glu Asn
450 455 460TCT CGT GTG GTA TGT GTC AAA AAG GGG AAT TAT TTA TTC AAC GAA GTT T 1503Ser Arg Val Val Cys Val Lys Lys Gly Asn Tyr Leu Phe Asn Glu Val
465 470 475AAGATGGTGG CTTGAGGCGG AATCGAACCA CCGACACGAA GATTTTC 1550
(2) Sequence 312 data:
(i) sequence characteristics:
(A) length: 479 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 312: met Lys Lys Ser Leu Cys Leu Ser Phe Phe Leu Thr Phe Ser Asn Pro 151015 Leu Gln Ala Leu Val Ile Glu Leu Leu Glu Glu Ile Lys Thr Ser Pro
20 25 30His Lys Gly Thr Phe Lys Ala Lys Val Leu Asp Ser Lys Lys Pro Arg
35 40 45Gln Val Leu Gly Val Tyr Asn Ile Ser Pro His Lys Lys Leu Thr Leu
50 55 60Thr Ile Thr His Ile Ser Thr Ala Ile Val Tyr Gln Pro Leu Asp Glu65 70 75 80Lys Leu Ser Leu Glu Thr Thr Leu Asn Pro Asn Arg Pro Thr Ile Pro
85 90 95Arg Asn Thr Gln Ile Val Phe Ser Ser Lys Glu Leu Lys Glu Ser His
100 105 110Pro His Gln Met Pro Ser Leu Asn Ala Pro Met Gln Lys Pro Gln Asn
115 120 125Lys Pro His Ser Ser Gln Gln Pro Ser Gln Asn Phe Ser Tyr Pro Glu
130 135 140Pro Lys Leu Gly Ser Lys Asn Ser Lys Asn Ser Leu Leu Gln Pro Leu145 150 155 160Ala Ile Pro Ser Lys Ile Ser Pro Thr Asn Glu Thr Gln Thr Pro Thr
165 170 175Asn Asp Thr Lys Pro Pro Leu Lys His Ser Ser Glu Asp Gln Glu Ser
180 185 190Asn Leu Phe Ile Thr Pro Pro Thr Glu Lys Thr Leu Pro Asn Asn Thr
195 200 205Ser Asn Ala Asp Ile Ser Glu Asn Asn Glu Ser Asn Glu Asn Lys Asp
210 215 220Asn Val Glu Lys Gln Ala Ile Arg Asp Ala Asn Ile Lys Glu Phe Ala225 230 235 240Cys Gly Lys Trp Val Tyr Asp Asp Glu Asn Leu Gln Ala Tyr Arg Pro
245 250 255Ser Ile Leu Lys Arg Val Asp Glu Asp Lys Gln Thr Ala Thr Asp Ile
260 265 270Thr Pro Cys Asp Tyr Ser Thr Ala Glu Asn Lys Ser Gly Lys Ile Ile
275 280 285Thr Pro Tyr Thr Lys Ile Ser Val His Lys Thr Glu Pro Leu Glu Glu
290 295 300Pro Gln Thr Phe Glu Ala Lys Asn Asn Phe Ala Ile Leu Gln Ala Arg305 310 315 320Ser Ser Thr Glu Lys Cys Lys Arg Ala Arg Ala Arg Lys Asp Gly Thr
325 330 335Thr Arg Gln Cys Tyr Leu Ile Glu Glu Pro Leu Lys Gln Ala Trp Glu
340 345 350Ser Glu Tyr Glu Ile Thr Thr Gln Leu Val Lys Ala Ile Tyr Glu Arg
355 360 365Pro Lys Gln Asp Asp Gln Val Glu Pro Thr Phe Tyr Glu Thr Ser Glu
370 375 380Leu Ala Tyr Ser Ser Thr Arg Lys Ser Glu Ile Thr His Asn Glu Leu385 390 395 400Asn Leu Asn Glu Lys Phe Met Glu Phe Val Glu Val Tyr Glu Gly His
405 410 415Tyr Leu Asn Asp Ile Ile Lys Glu Ser Ser Glu Tyr Lys Glu Trp Val
420 425 430Lys Asn His Val Arg Phe Lys Glu Gly Val Cys Met Ala Leu Glu Ile
435 440 445Glu Glu Gln Pro Arg Ala Lys Ser Thr Pro Leu Ser Ile Glu Asn Ser
450455460 Arg Val Val Cys Val Lys Lys Gly Asn Tyr Leu Phe Asn Glu Val 465470475 (2) sequence 313 data: (i) sequence characteristics: length (A): 620bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 68...568 (D) other information: (xi) Description of the sequence: sequence 313: TGTAAAATAG GGATTTGCTA GGCCTTTAGT CGTTAAAAGG TAATTATCAT TAAGGAGTTT 60TTTAATC ATG GCA GAT ATT CAA AGG CGT GAT TTT TTA GGA ATG AGC CTT 109
Met Ala Asp Ile Gln Arg Arg Asp Phe Leu Gly Met Ser Leu
1 5 10GCT AGT GTT ACA GCT ATA GGG GCT ATA GCG AGT CTG GTA GCG ATG AAA 157Ala Ser Val Thr Ala lle Gly Ala Ile Ala Ser Leu Val Ala Met Lys15 20 25 30AAG ACT TGG GAT CCG CTT CCA AGC GTT GTT TCA GCC GGT TTT ACG ACC 205Lys Thr Trp Asp Pro Leu Pro Ser Val Val Ser Ala Gly Phe Thr Thr
35 40 45ATA GAT GTG GCG AAT ATG CAA GAA GGG CAG TTT TCC ACC GTG GAA TGG 253Ile Asp Val Ala Asn Met Gln Glu Gly Gln Phe Ser Thr Val Glu Trp
50 55 60CGT GGG AAA CCG GTC TAT ATC CTC AAG CGT TCT AAA AAA GAG GGC TTT 301Arg Gly Lys Pro Val Tyr Ile Leu Lys Arg Ser Lys Lys Glu Gly Phe
65 70 75AAT GAA AAG CGC GAT TTT AAA GTT GGC GAG AGC GTT TTT ACC ACA GCC 349Asn Glu Lys Arg Asp Phe Lys Val Gly Glu Ser Val Phe Thr Thr Ala
80 85 90ATT CAA ATT TGC ACG CAT TTA GGG TGT ATC CCC ACT TAT CAA GAT GAA 397Ile Gln Ile Cys Thr His Leu Gly Cys Ile Pro Thr Tyr Gln Asp Glu95 100 105 110GAA AAA GGC TTT TTA TGC CCA TGC CAT GGG GGG CGT TTC ACT TCT GAT 445Glu Lys Gly Phe Leu Cys Pro Cys His Gly Gly Arg Phe Thr Ser Asp
115 120 125GGC GTG AAT ATT GCC GGC ACT CCC CCT CCA CGC CCT TTT GAT ATC CCG 493Gly Val Asn Ile Ala Gly Thr Pro Pro Pro Arg Pro Phe Asp Ile Pro
130 135 140CCT TTT AAA ATT GAA GGC ACT AAG ATC ACT TTT GGT GAA GCC GGG GCT 541Pro Phe Lys Ile Glu Gly Thr Lys Ile Thr Phe Gly Glu Ala Gly Ala
145 150 155GAA TAC AAG AAA ATG ATG GCT AAA GCG TAAGGAGAGT TTAATGGCAG AGATAAA 595Glu Tyr Lys Lys Met Met Ala Lys Ala
160 165AAAAGCGAAA AATTTAGGCG AATGG 620
(2) Sequence 314 data:
(i) sequence characteristics:
(A) length: 167 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 314: met Ala Asp Ile Gln Arg Arg Asp Phe Leu Gly Met Ser Leu Ala Ser 151015 Val Thr Ala Ile Gly Ala Ile Ala Ser Leu Val Ala Met Lys Lys Thr
20 25 30Trp Asp Pro Leu Pro Ser Val Val Ser Ala Gly Phe Thr Thr Ile Asp
35 40 45Val Ala Asn Met Gln Glu Gly Gln Phe Ser Thr Val Glu Trp Arg Gly
50 55 60Lys Pro Val Tyr Ile Leu Lys Arg Ser Lys Lys Glu Gly Phe Asn Glu65 70 75 80Lys Arg Asp Phe Lys Val Gly Glu Ser Val Phe Thr Thr Ala Ile Gln
85 90 95Ile Cys Thr His Leu Gly Cys Ile Pro Thr Tyr Gln Asp Glu Glu Lys
100 105 110Gly Phe Leu Cys Pro Cys His Gly Gly Arg Phe Thr Ser Asp Gly Val
115 120 125Asn Ile Ala Gly Thr Pro Pro Pro Arg Pro Phe Asp Ile Pro Pro Phe
130 135 140Lys Ile Glu Gly Thr Lys Ile Thr Phe Gly Glu Ala Gly Ala Glu Tyr145 150 155 160Lys Lys Met Met Ala Lys Ala
165
(2) Sequence 315 data:
(i) sequence characteristics:
(A) length: 1221bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...1167
(D) Other information:
(xi) Description of the sequence: sequence 315: TTATAATCAA AGCTATTTTA AAAGCTGAAT AGCTATAGTT ATTAGGATGC G ATG TCA 57
Met Ser
1AAA AGA ATG AAG TGT TTT AGT CAA AAA TGG TTG GTT TTT TTT GTT ACC 105Lys Arg Met Lys Cys Phe Ser Gln Lys Trp Leu Val Phe Phe Val Thr
5 10 15CTT TTA TTG GCT TCT TTA GGC CAT GCG AAA ATG GCT TTT GAA TCC GAT 153Leu Leu Leu Ala Ser Leu Gly His Ala Lys Met Ala Phe Glu Ser Asp
20 25 30ATT GAC ACC AAA GCG CTA GAG GCT TTT GGG GTT AAT GCG GGC TTT TTA 201Ile Asp Thr Lys Ala Leu Glu Ala Phe Gly Val Asn Ala Gly Phe Leu35 40 45 50TCC CAA ATG CCC AAC GCT TTA AAA AAA ATG AAT AAA GAA GAA GAA TGG 249Ser Gln Met Pro Asn Ala Leu Lys Lys Met Asn Lys Glu Glu Glu Trp
55 60 65AAG AGA CTT GTC AAA AGA TTT GAT GTG AAT TAC CAG TTC ATC CCC ATC 297Lys Arg Leu Val Lys Arg Phe Asp Val Asn Tyr Gln Phe Ile Pro Ile
70 75 80ATT AAA AAC ATG CTC ATA GAA GCG AGC GTG CCG CAA GAA TTT TTA TTT 345Ile Lys Asn Met Leu Ile Glu Ala Ser Val Pro Gln Glu Phe Leu Phe
85 90 95TTA GCC ATG GCC GAG TCT AAA TTT TCA TCA AGG GCT TAT AGC AGG AAA 393Leu Ala Met Ala Glu Ser Lys Phe Ser Ser Arg Ala Tyr Ser Arg Lys
100 105 110AAA GCG GTA GGG ATT TGG CAA TTC ATG CCA AGC ACG GCT AAA GAA TTA 441Lys Ala Val Gly Ile Trp Gln Phe Met Pro Ser Thr Ala Lys Glu Leu115 120 125 130GGG CTT AAG GTC AAT CAT TAC ATT GAT GAAAGA AGA GAT CCC ATT AAA 489Gly Leu Lys Val Asn His Tyr Ile Asp Glu Arg Arg Asp Pro Ile Lys
135 140 145AGC ACT CAA GCG GCG ATC ACT TAT TTG AAA CGG CTC TAC AAG CAA ACC 537Ser Thr Gln Ala Ala Ile Thr Tyr Leu Lys Arg Leu Tyr Lys Gln Thr
150 155 160GGA GAG TGG TAT TTG GTC GCT ATG GCG TAT AAT TAC GGC TTA CGC AAG 585Gly Glu Trp Tyr Leu Val Ala Met Ala Tyr Asn Tyr Gly Leu Arg Lys
165 170 175GTT CAA AAC GCT ATT AAA GCC GCC GGC ACT TCG GAC ATT AAA ATT TTG 633Val Gln Asn Ala Ile Lys Ala Ala Gly Thr Ser Asp Ile Lys Ile Leu
180 185 190TTG GAT GAA GAT AAG AAA TAC CTC CCT AAA GAA ACA CGA GAG TAT ATC 681Leu Asp Glu Asp Lys Lys Tyr Leu Pro Lys Glu Thr Arg Glu Tyr Ile195 200 205 210CGC TCC ATT CTA AGC CTA GCG TTA AAA TTC AAC AGC CTA GAC AAC CTC 729Arg Ser Ile Leu Ser Leu Ala Leu Lys Phe Asn Ser Leu Asp Asn Leu
215 220 225AAA GAT AAA GAA TAT CTG CTC AAT CGT GGG GCG AGG GTG AGT TTA GTG 777Lys Asp Lys Glu Tyr Leu Leu Asn Arg Gly Ala Arg Val Ser Leu Val
230 235 240GGC GTC CCG TTT AAA AGG CGT GCT TCT TTA GTC CAA GTA GCC AAA AAT 825Gly Val Pro Phe Lys Arg Arg Ala Ser Leu Val Gln Val Ala Lys Asn
245 250 255TTG AAT TTG AGT TTG GAA ACC TTA AAA TCC TAC AAC CAC CAA TTC CGT 873Leu Asn Leu Ser Leu Glu Thr Leu Lys Ser Tyr Asn His Gln Phe Arg
260 265 270TAT AAC ATT CTG CCT TCT AAA GAC CCC ACT TAT ACC ATT TAT ATC CCT 921Tyr Asn Ile Leu Pro Ser Lys Asp Pro Thr TyrThr Ile Tyr Ile Pro275 280 285 290TAT GAA AAA CTC GCT CTT TTC AAA CAA CGC CAG ATC AAA CAA AAT AAA 969Tyr Glu Lys Leu Ala Leu Phe Lys Gln Arg Gln Ile Lys Gln Asn Lys
295 300 305AAC ATT CAA GCC AGT TCA AAA AGC CCT TTT ATC ACC CAT GTG GTC TTA 1017Asn Ile Gln Ala Ser Ser Lys Ser Pro Phe Ile Thr His Val Val Leu
310 315 320CCT AAA GAA ACC CTA TCT TCT ATC GCT AAA CGC TAT CAA GTC AGT ATT 1065Pro Lys Glu Thr Leu Ser Ser Ile Ala Lys Arg Tyr Gln Val Ser Ile
325 330 335TCC AAT ATC CAA TTA GCC AAT GAT CTC AAA GAT TCT AAT ATT TTT ATC 1113Ser Asn Ile Gln Leu Ala Asn Asp Leu Lys Asp Ser Asn Ile Phe Ile
340 345 350CAC CAG CGT TTA ATC ATC CCC ACC AAC AAA AAA TTA CTC GCT ACA AGG 1161His Gln Arg Leu Ile Ile Pro Thr Asn Lys Lys Leu Leu Ala Thr Arg355 360 365 370GAA TTT TAATGGGTTT GGCGTTGGAA AAAGTTTGTT TTTTAGGCGT TATTTTTTTG AT 1219Glu PheTA 1221
(2) Data of sequence 316:
(i) sequence characteristics:
(A) length: 372 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 316: met Ser Lys Arg Met Lys Cys Phe Ser Gln Lys Trp Leu Val Phe Phe 151015 Val Thr Leu Leu Leu Ala Ser Leu Gly His Ala Lys Met Ala Phe Glu
20 25 30Ser Asp Ile Asp Thr Lys Ala Leu Glu Ala Phe Gly Val Asn Ala Gly
35 40 45Phe Leu Ser Gln Met Pro Asn Ala Leu Lys Lys Met Asn Lys Glu Glu
50 55 60Glu Trp Lys Arg Leu Val Lys Arg Phe Asp Val Asn Tyr Gln Phe Ile65 70 75 80Pro Ile Ile Lys Asn Met Leu Ile Glu Ala Ser Val Pro Gln Glu Phe
85 90 95Leu Phe Leu Ala Met Ala Glu Ser Lys Phe Ser Ser Arg Ala Tyr Ser
100 105 110Arg Lys Lys Ala Val Gly Ile Trp Gln Phe Met Pro Ser Thr Ala Lys
115 120 125Glu Leu Gly Leu Lys Val Asn His Tyr Ile Asp Glu Arg Arg Asp Pro
130 135 140Ile Lys Ser Thr Gln Ala Ala Ile Thr Tyr Leu Lys Arg Leu Tyr Lys145 150 155 160Gln Thr Gly Glu Trp Tyr Leu Val Ala Met Ala Tyr Asn Tyr Gly Leu
165 170 175Arg Lys Val Gln Asn Ala Ile Lys Ala Ala Gly Thr Ser Asp Ile Lys
180 185 190Ile Leu Leu Asp Glu Asp Lys Lys Tyr Leu Pro Lys Glu Thr Arg Glu
195 200 205Tyr Ile Arg Ser Ile Leu Ser Leu Ala Leu Lys Phe Asn Ser Leu Asp
210 215 220Asn Leu Lys Asp Lys Glu Tyr Leu Leu Asn Arg Gly Ala Arg Val Ser225 230 235 240Leu Val Gly Val Pro Phe Lys Arg Arg Ala Ser Leu Val Gln Val Ala
245 250 255Lys Asn Leu Asn Leu Ser Leu Glu Thr Leu Lys Ser Tyr Asn His Gln
260 265 270Phe Arg Tyr Asn Ile Leu Pro Ser Lys Asp Pro Thr Tyr Thr Ile Tyr
275 280 285Ile Pro Tyr Glu Lys Leu Ala Leu Phe Lys Gln Arg Gln Ile Lys Gln
290 295 300Asn Lys Asn Ile Gln Ala Ser Ser Lys Ser Pro Phe Ile Thr His Val305 310 315 320Val Leu Pro Lys Glu Thr Leu Ser Ser Ile Ala Lys Arg Tyr Gln Val
325 330 335Ser Ile Ser Asn Ile Gln Leu Ala Asn Asp Leu Lys Asp Ser Asn Ile
340 345 350Phe Ile His Gln Arg Leu Ile Ile Pro Thr Asn Lys Lys Leu Leu Ala
355 360 365Thr Arg Glu Phe
370
(2) Sequence 317 data:
(i) sequence characteristics:
(A) length: 561bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 46...510
(D) Other information:
(xi) Description of the sequence: sequence 317: AAATGAGCTA AAATGAGCGT TTCATTTGAC AAATAAAGGG ATTGA ATG GCT TTT AAG 57
Met Ala Phe Lys
1GTG GTG CAA ATT TGC GGA GGG CTT GGG AAT CAA ATG TTT CAA TAC GCT 105Val Val Gln Ile Cys Gly Gly Leu Gly Asn Gln Met Phe Gln Tyr Ala 5 10 15 20TTC GCT AAA AGT TTG CAA AAA CAC TCT AAT ACG CCT GTG CTG TTA GAT 153Phe Ala Lys Ser Leu Gln Lys His Ser Asn Thr Pro Val Leu Leu Asp
25 30 35ATC ACT TCT TTT GAT TGG AGC GAT AGG AAA ATG CAA TTA GAA CTT TTC 201Ile Thr Ser Phe Asp Trp Ser Asp Arg Lys Met Gln Leu Glu Leu Phe
40 45 50CCT ATT GAT TTG CCC TAT GCG AGC GCG AAA GAA ATC GCT ATA GCT AAA 249Pro Ile Asp Leu Pro Tyr Ala Ser Ala Lys Glu Ile Ala Ile Ala Lys
55 60 65ATG CAA CAC CTC CCC AAG CTA GTA AGA GAC GCG CTC AAA TGC ATG GGA 297Met Gln His Leu Pro Lys Leu Val Arg Asp Ala Leu Lys Cys Met Gly
70 75 80TTT GAT AGG GTG AGT CAA GAA ATC GTT TTT GAA TAC GAG CCT AAA TTG 345Phe Asp Arg Val Ser Gln Glu Ile Val Phe Glu Tyr Glu Pro Lys Leu85 90 95 100CTA AAG CCA AGC CGC TTG ACT TAT TTT TTT GGC TAT TTC CAA GAT CCA 393Leu Lys Pro Ser Arg Leu Thr Tyr Phe Phe Gly Tyr Phe Gln Asp Pro
105 110 115CGA TAC TTT GAT GCT ATA TCC CCT TTA ATC AAG CAA ACC TTC ACT CTA 441Arg Tyr Phe Asp Ala Ile Ser Pro Leu Ile Lys Gln Thr Phe Thr Leu
120 125 130CCC CCC CCC CCC CCG AAA ATA ATA AGA ATA ATA ATA AAA AAG AGG AAG 489Pro Pro Pro Pro Pro Lys Ile Ile Arg Ile Ile Ile Lys Lys Arg Lys
135 140 145AAT ATC AGT GCA AGC TTT CTT TGATTTTAGC CGCTAAAAAC AGCGTGTTTG TGCA 544Asn Ile Ser Ala Ser Phe Leu
150 155TATAAGAAGA GGGGATT 561
(2) Sequence 318 data:
(i) sequence characteristics:
(A) length: 155 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 318: met Ala Phe Lys Val Val Gln Ile Cys Gly Gly Leu Gly Asn Gln Met 151015 Phe Gln Tyr Ala Phe Ala Lys Ser Leu Gln Lys His Ser Asn Thr Pro
20 25 30Val Leu Leu Asp Ile Thr Ser Phe Asp Trp Ser Asp Arg Lys Met Gln
35 40 45Leu Glu Leu Phe Pro Ile Asp Leu Pro Tyr Ala Ser Ala Lys Glu Ile
50 55 60Ala Ile Ala Lys Met Gln His Leu Pro Lys Leu Val Arg Asp Ala Leu65 70 75 80Lys Cys Met Gly Phe Asp Arg Val Ser Gln Glu Ile Val Phe Glu Tyr
85 90 95Glu Pro Lys Leu Leu Lys Pro Ser Arg Leu Thr Tyr Phe Phe Gly Tyr
100 105 110Phe Gln Asp Pro Arg Tyr Phe Asp Ala Ile Ser Pro Leu Ile Lys Gln
115 120 125Thr Phe Thr Leu Pro Pro Pro Pro Pro Lys Ile Ile Arg Ile Ile Ile
130 135 140Lys Lys Arg Lys Asn Ile Ser Ala Ser Phe Leu145 150 155
(2) Sequence 319 data:
(i) sequence characteristics:
(A) length: 1251bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 86...1201
(D) Other information:
(xi) Description of the sequence: sequence 319: GGTTATTATA GTATAATATT GTCAAAAAAT AAATTCAACT TTGGATTAAA TTGATTAAAA 60ACCTATTTTA GGGAAACCGC TTAAA ATG AGT ATT ATT ATT CCT ATT GTC ATC 112
Met Ser Ile Ile Ile Pro Ile Val Ile
1 5GCT TTT GAT AAT CAC TAT GCC ATG CCG GCT GGC GTG AGC TTG TAT TCC 160Ala Phe Asp Asn His Tyr Ala Met Pro Ala Gly Val Ser Leu Tyr Ser10 15 20 25ATG CTA GCT TGC GCT AAA ACA GAA CAC CCC CAA TCA CAA AAT GAT AGT 208Met Leu Ala Cys Ala Lys Thr Glu His Pro Gln Ser Gln Asn Asp Ser
30 35 40GAA AAA CTT TTT TAT AAG ATC CAC TGC CTG GTG GAT AAC TTA AGC CTT 256Glu Lys Leu Phe Tyr Lys Ile His Cys Leu Val Asp Asn Leu Ser Leu
45 50 55GAA AAC CAG AGC AAA CTA AAA GAG ACT CTA GCC CCC TTT AGC GCT TTT 304Glu Asn Gln Ser Lys Leu Lys Glu Thr Leu Ala Pro Phe Ser Ala Phe
60 65 70TCG AGC CTA GAA TTT TTA GAC ATT TCA ACC CCC AAT CTT CAC GCC ACT 352Ser Ser Leu Glu Phe Leu Asp Ile Ser Thr Pro Asn Leu His Ala Thr
75 80 85CCA ATA GAA CCC TCT GCG ATT GAT AAA ATC AAT GAA GCT TTT TTG CAA 400Pro Ile Glu Pro Ser Ala Ile Asp Lys Ile Asn Glu Ala Phe Leu Gln90 95 100 105CTC AAT ATT TAC GCT AAG ACT CGC TTT TCT AAA ATG GTC ATG TGC CGC 448Leu Asn Ile Tyr Ala Lys Thr Arg Phe Ser Lys Met Val Met Cys Arg
110 115 120TTG TTT TTG GCT TCT TTA TTC CCA CAA TAC GAC AAA ATC ATC ATG TTT 496Leu Phe Leu Ala Ser Leu Phe Pro Gln Tyr Asp Lys Ile Ile Met Phe
125 130 135GAT GCA GAC ACT TTG TTT TTA AAC GAT GTG AGC GAG AGC TTT TTC ATC 544Asp Ala Asp Thr Leu Phe Leu Asn Asp Val Ser Glu Ser Phe Phe Ile
140 145 150CCA CTA GAT GGC TAT TAT TTT GGA GCG GCT AAA GAT TTT GCT TCC GAT 592Pro Leu Asp Gly Tyr Tyr Phe Gly Ala Ala Lys Asp Phe Ala Ser Asp
155 160 165AAA AGC CCT AAA CAT TTT CAA ATA GTG CGA GAA AAA GAC CCT CGT CAA 640Lys Ser Pro Lys His Phe Gln Ile Val Arg Glu Lys Asp Pro Arg Gln170 175 180 185GCC TTT TCC CTT TAT GAG CAT TAC CTT AAT GAA AGC GAT ATG CAA ATC 688Ala Phe Ser Leu Tyr Glu His Tyr Leu Asn Glu Ser Asp Met Gln Ile
190 195 200ATC TAT GAA AGC AAT TAT AAC GCC GGG TTT TTA GTC GTG AAT TTA AAG 736Ile Tyr Glu Ser Asn Tyr Asn Ala Gly Phe Leu Val Val Asn Leu Lys
205 210 215CTG TGG CGT GCT GAT CAT TTA GAA GAG CGC TTA CTC AAT TTA ACC CAT 784Leu Trp Arg Ala Asp His Leu Glu Glu Arg Leu Leu Asn Leu Thr His
220 225 230CAA AAA GGC CAG TGC GTG TTT TAC CCT GAA CAG GAC CTT TTA ACG CTC 832Gln Lys Gly Gln Cys Val Phe Tyr Pro Glu Gln Asp Leu Leu Thr Leu
235 240 245GCA TGC TAT CAA AAA GTT TTA ATC TTG CCT TAT ATT TAT AAC ACC CAC 880Ala Cys Tyr Gln Lys Val Leu Ile Leu Pro Tyr Ile Tyr Asn Thr His250 255 260 265CCT TTC ATG GCC AAT CAA AAA CGC TTC ATC CCT GAC AAA AAA GAA ATC 928Pro Phe Met Ala Asn Gln Lys Arg Phe Ile Pro Asp Lys Lys Glu Ile
270 275 280GTC ATG CTG CAT TTT TAT TTT GTA GGA AAA CCT TGG GTT TTA CCT ACT 976Val Met Leu His Phe Tyr Phe Val Gly Lys Pro Trp Val Leu Pro Thr
285 290 295TTT TCA TAT TCT AAA GAA TGG CAT GAG ACT CTT TTA AAA ACC CCT TTT 1024Phe Ser Tyr Ser Lys Glu Trp His Glu Thr Leu Leu Lys Thr Pro Phe
300 305 310TAT GCT GAA TAT TCC GTG AAA TTC CTT AAA CAA ATG ACA GAA TGT TTA 1072Tyr Ala Glu Tyr Ser Val Lys Phe Leu Lys Gln Met Thr Glu Cys Leu
315 320 325AGC CTT AAA GAC AAA CAA AAA ACC TTT GAA TTT CTT GCC CCC CTA CTC 1120Ser Leu Lys Asp Lys Gln Lys Thr Phe Glu Phe Leu Ala Pro Leu Leu330 335 340 345AAT AAA AAA ACC CTT TTA GAA TAC GTC TTT TTT AGA TTG AAT AGG ATT 1168Asn Lys Lys Thr Leu Leu Glu Tyr Val Phe Phe Arg Leu Asn Arg Ile
350 355 360TTC AAA CGC TTA AAA GAA AAA TTT TTT AAC TCT TAGCGTTCTC GTTTGGGCAA 1221Phe Lys Arg Leu Lys Glu Lys Phe Phe Asn Ser
365 370CACGCTATAG GCGAATTTGA CATAAATCGC 1251
(2) Sequence 320 data:
(i) sequence characteristics:
(A) length: 372 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 320: met Ser Ile Ile Ile Pro Ile Val Ile Ala Phe Asp Asn His Tyr Ala 151015 Met Pro Ala Gly Val Ser Leu Tyr Ser Met Leu Ala Cys Ala Lys Thr
20 25 30Glu His Pro Gln Ser Gln Asn Asp Ser Glu Lys Leu Phe Tyr Lys Ile
35 40 45His Cys Leu Val Asp Asn Leu Ser Leu Glu Asn Gln Ser Lys Leu Lys
50 55 60Glu Thr Leu Ala Pro Phe Ser Ala Phe Ser Ser Leu Glu Phe Leu Asp65 70 75 80Ile Ser Thr Pro Asn Leu His Ala Thr Pro Ile Glu Pro Ser Ala Ile
85 90 95Asp Lys Ile Asn Glu Ala Phe Leu Gln Leu Asn Ile Tyr Ala Lys Thr
100 105 110Arg Phe Ser Lys Met Val Met Cys Arg Leu Phe Leu Ala Ser Leu Phe
115 120 125Pro Gln Tyr Asp Lys Ile Ile Met Phe Asp Ala Asp Thr Leu Phe Leu
130 135 140Asn Asp Val Ser Glu Ser Phe Phe Ile Pro Leu Asp Gly Tyr Tyr Phe145 150155 160Gly Ala Ala Lys Asp Phe Ala Ser Asp Lys Ser Pro Lys His Phe Gln
165 170 175Ile Val Arg Glu Lys Asp Pro Arg Gln Ala Phe Ser Leu Tyr Glu His
180 185 190Tyr Leu Asn Glu Ser Asp Met Gln Ile Ile Tyr Glu Ser Asn Tyr Asn
195 200 205Ala Gly Phe Leu Val Val Asn Leu Lys Leu Trp Arg Ala Asp His Leu
210 215 220Glu Glu Arg Leu Leu Asn Leu Thr His Gln Lys Gly Gln Cys Val Phe225 230 235 240Tyr Pro Glu Gln Asp Leu Leu Thr Leu Ala Cys Tyr Gln Lys Val Leu
245 250 255Ile Leu Pro Tyr Ile Tyr Asn Thr His Pro Phe Met Ala Asn Gln Lys
260 265 270Arg Phe Ile Pro Asp Lys Lys Glu Ile Val Met Leu His Phe Tyr Phe
275 280 285Val Gly Lys Pro Trp Val Leu Pro Thr Phe Ser Tyr Ser Lys Glu Trp
290 295 300His Glu Thr Leu Leu Lys Thr Pro Phe Tyr Ala Glu Tyr Ser Val Lys305 310 315 320Phe Leu Lys Gln Met Thr Glu Cys Leu Ser Leu Lys Asp Lys Gln Lys
325 330 335Thr Phe Glu Phe Leu Ala Pro Leu Leu Asn Lys Lys Thr Leu Leu Glu
340 345 350Tyr Val Phe Phe Arg Leu Asn Arg Ile Phe Lys Arg Leu Lys Glu Lys
355 360 365Phe Phe Asn Ser
370
(2) Sequence 321 data:
(i) sequence characteristics:
(A) length: 2241bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...2193
(D) Other information:
(xi) Description of the sequence: sequence 321: CAAGAAGCCA TAGAAGCTGA TGGGAAATTC CACAAAGAAT AAGGGTAGAA A ATG AAA 57
Met Lys
1ATA ACA TAT TGT GAT GCG CTA ATT ATT GGA GGC GGA CTA GCT GGG TTA 105Ile Thr Tyr Cys Asp Ala Leu Ile Ile Gly Gly Gly Leu Ala Gly Leu
5 10 15AGG GCT AGT ATC GCA TGC AAA CAA AAG GGT TTA AAC ACC ATC GTT TTA 153Arg Ala Ser Ile Ala Cys Lys Gln Lys Gly Leu Asn Thr Ile Val Leu
20 25 30AGC CTA GTG CCT GTC AGG CGT TCG CAC TCT GCA GCC GCT CAA GGG GGC 201Ser Leu Val Pro Val Arg Arg Ser His Ser Ala Ala Ala Gln Gly Gly35 40 45 50ATG CAA GCG AGC CTT GCG AAC GCT AAA AAA AGC GAG GGC GAT AAT GAA 249Met Gln Ala Ser Leu Ala Asn Ala Lys Lys Ser Glu Gly Asp Asn Glu
55 60 65GAT TTA CAC TTT TTA GAC ACG GTT AAG GGG AGC GAT TGG GGG TGC GAT 297Asp Leu His Phe Leu Asp Thr Val Lys Gly Ser Asp Trp Gly Cys Asp
7075 80CAG CAA GTG GCT AGG ATG TTT GTA ACC ACT GCT CCT AAA GCC ATT AGG 345Gln Gln Val Ala Arg Met Phe Val Thr Thr Ala Pro Lys Ala Ile Arg
85 90 95GAA TTG GCC AGT TGG GGG GTG CCT TGG ACT AGG ATT AAA AAG GGC GAT 393Glu Leu Ala Ser Trp Gly Val Pro Trp Thr Arg Ile Lys Lys Gly Asp
100 105 110AGG CCT GCG GTC GTC AAT GGT GAG CAT GTA ACT ATC ACT GAA AGA GAC 441Arg Pro Ala Val Val Asn Gly Glu His Val Thr Ile Thr Glu Arg Asp115 120 125 130GAC AGG CAT GGT TAT ATC TTA AGC CGT GAT TTT GGC GGC ACT AAA AAA 489Asp Arg His Gly Tyr Ile Leu Ser Arg Asp Phe Gly Gly Thr Lys Lys
135 140 145TGG CGC ACA TGC TTT ACG GCT GAT GCC ACA GGG CAT ACC ATG CTT TAT 537Trp Arg Thr Cys Phe Thr Ala Asp Ala Thr Gly His Thr Met Leu Tyr
150 155 160GCG GTC GCT AAT GAA GCC TTA CAC CAC AAA GTG GAT ATT CAA GAC AGA 585Ala Val Ala Asn Glu Ala Leu His His Lys Val Asp Ile Gln Asp Arg
165 170 175AAG GAC ATG CTC GCT TTC ATT CAT CAT GAT AAT AAA TGC TAT GGG GCG 633Lys Asp Met Leu Ala Phe Ile His His Asp Asn Lys Cys Tyr Gly Ala
180 185 190GTG GTA AGG GAT TTG ATC ACA GGC GAA ATT TCA GCG TAT GTT TCT AAA 681Val Val Arg Asp Leu Ile Thr Gly Glu Ile Ser Ala Tyr Val Ser Lys195 200 205 210GGC ACG CTT TTA GCT ACC GGA GGT TAT GGG CGC GTG TAT AAA CAC ACC 729Gly Thr Leu Leu Ala Thr Gly Gly Tyr Gly Arg Val Tyr Lys His Thr
215 220 225ACT AAC GCT GTG ATT TGC GAT GGA GCC GGG GCT GCA AGC GCC TTA GAA 777Thr Asn Ala Val Ile CysAsp Gly Ala Gly Ala Ala Ser Ala Leu Glu
230 235 240ACC GGC GTG GCT AAA TTG GGC AAC ATG GAA GCG GTG CAA TTC CAC CCT 825Thr Gly Val Ala Lys Leu Gly Asn Met Glu Ala Val Gln Phe His Pro
245 250 255ACC GCT TTA GTG CCA AGC GGG ATT TTA ATG ACC GAA GGT TGC AGG GGC 873Thr Ala Leu Val Pro Ser Gly Ile Leu Met Thr Glu Gly Cys Arg Gly
260 265 270GAT GGC GGT GTT TTA AGA GAC AAG TTT GGC AGA CGC TTC ATG CCC GCT 921Asp Gly Gly Val Leu Arg Asp Lys Phe Gly Arg Arg Phe Met Pro Ala275 280 285 290TAT GAG CCG GAG AAA AAA GAG CTT GCA AGC AGA GAT GTG GTC TCA AGG 969Tyr Glu Pro Glu Lys Lys Glu Leu Ala Ser Arg Asp Val Val Ser Arg
295 300 305CGG ATT TTA GAG CAT ATC CAA AAA GGC TAT GGA GCC AAA TCG CCT TAT 1017Arg Ile Leu Glu His Ile Gln Lys Gly Tyr Gly Ala Lys Ser Pro Tyr
310 315 320GGG GAT CAT GTG TGG CTG GAT ATT GCT ATT TTA GGG CGT AAC CAT GTG 1065Gly Asp His Val Trp Leu Asp Ile Ala Ile Leu Gly Arg Asn His Val
325 330 335GAA AAA AAC TTA AGG GAT GTG CGC GAT ATA GCC ATG ACT TTT GCG GGC 1113Glu Lys Asn Leu Arg Asp Val Arg Asp Ile Ala Met Thr Phe Ala Gly
340 345 350ATT GAT CCG GCT GAT AGC AAG GAA CAA ACC AAA GAC AAC ATG CAA GGA 1161Ile Asp Pro Ala Asp Ser Lys Glu Gln Thr Lys Asp Asn Met Gln Gly355 360 365 370GTG CCC GCA AAT GAG CCT GAA TAC GGG CAA GCG ATG GCC AAG CAA AAA 1209Val Pro Ala Asn Glu Pro Glu Tyr Gly Gln Ala Met Ala Lys Gln Lys
375380 385GGC TGG ATC CCC ATA AAA CCC ATG CAA CAC TAT TCT ATG GGT GGG GTT 1257Gly Trp Ile Pro Ile Lys Pro Met Gln His Tyr Ser Met Gly Gly Val
390 395 400AGG ACA AAC CCT AAA GGC GAA ACC CAT TTA AAA GGC TTG TTT TGC GCG 1305Arg Thr Asn Pro Lys Gly Glu Thr His Leu Lys Gly Leu Phe Cys Ala
405 410 415GGT GAA GCG GCA TGC TGG GAT TTG CAT GGG TTT AAC CGC TTG GGG GGT 1353Gly Glu Ala Ala Cys Trp Asp Leu His Gly Phe Asn Arg Leu Gly Gly
420 425 430AAT TCT GTG AGT GAA GCG GTG GTC GCT GGC ATG ATC ATT GGG GAT TAT 1401Asn Ser Val Ser Glu Ala Val Val Ala Gly Met Ile Ile Gly Asp Tyr435 440 445 450TTT GCC TCG CAT TGT TTA GAA GCG CAA ATT GAA ATC AAC ACG CAA AAA 1449Phe Ala Ser His Cys Leu Glu Ala Gln Ile Glu Ile Asn Thr Gln Lys
455 460 465GTT GAA GCT TTC ATT AAA GAA AGC CAA GAC TAT ATG CAT TTT TTA TTG 1497Val Glu Ala Phe Ile Lys Glu Ser Gln Asp Tyr Met His Phe Leu Leu
470 475 480CAT AAT GAA GGC AAA GAA GAT GTG TAT GAA ATT AGA GAG CGC ATG AAA 1545His Asn Glu Gly Lys Glu Asp Val Tyr Glu Ile Arg Glu Arg Met Lys
485 490 495GAA GTC ATG GAT GAA AAA GTG GGC GTT TTT AGA GAA GGC AAA AGG CTA 1593Glu Val Met Asp Glu Lys Val Gly Val Phe Arg Glu Gly Lys Arg Leu
500 505 510GAA GAA GCC CTT AAA GAA TTG CAA GAG CTT TAT GCA CGC TCC AAA AAC 1641Glu Glu Ala Leu Lys Glu Leu Gln Glu Leu Tyr Ala Arg Ser Lys Asn515 520 525 530ATT TGC GTG AAA AAC AAG GTT TTA CAC AAT AAC CCT GAA TTA GAA GAC 1689Ile Cys Val Lys Asn Lys Val Leu His Asn Asn Pro Glu Leu Glu Asp
535 540 545GCT TAC CGC ACC AAA AAA ATG CTC AAA CTC GCG CTT TGT ATC ACT CAA 1737Ala Tyr Arg Thr Lys Lys Met Leu Lys Leu Ala Leu Cys Ile Thr Gln
550 555 560GGA GCG TTA CTG CGC ACT GAA AGC AGA GGG GCT CAC ACA AGG ATT GAC 1785Gly Ala Leu Leu Arg Thr Glu Ser Arg Gly Ala His Thr Arg Ile Asp
565 570 575TAC CCT AAA AGA GAC GAT GAA AAA TGG CTT AAT CGG ACT CTA GCG AGC 1833Tyr Pro Lys Arg Asp Asp Glu Lys Trp Leu Asn Arg Thr Leu Ala Ser
580 585 590TGG CCT AGC GCT GAG CAA GAC ATG CCC ACG ATT GAA TAC GAA GAA TTA 1881Trp Pro Ser Ala Glu Gln Asp Met Pro Thr Ile Glu Tyr Glu Glu Leu595 600 605 610GAT GTG ATG AAA ATG GAA ATC AGC CCT GAT TTT AGG GGC TAT GGC AAA 1929Asp Val Met Lys Met Glu Ile Ser Pro Asp Phe Arg Gly Tyr Gly Lys
615 620 625AAG GGT AAT TTC ATC CCC CAC CCC AAA AAA GAA GAG CGC GAC GCT GAG 1977Lys Gly Asn Phe Ile Pro His Pro Lys Lys Glu Glu Arg Asp Ala Glu
630 635 640ATT TTG AAA ACG ATT TTA GAA CTA GAA AAG CTT GGA AAA GAC AGA ATA 2025Ile Leu Lys Thr Ile Leu Glu Leu Glu Lys Leu Gly Lys Asp Arg Ile
645 650 655GAA GTC CAA CAT GCG CTC ATG CCT TTT GAA TTG CAA GAA AAA TAC AAG 2073Glu Val Gln His Ala Leu Met Pro Phe Glu Leu Gln Glu Lys Tyr Lys
660 665 670GCT AGG AAT ATG CGT TTA GAA GAT GAG GAA GTC AGG GCT AGG GGG GAA 2121Ala Arg Asn Met Arg Leu Glu Asp Glu Glu Val Arg Ala Arg GlyGlu675 680 685 690CAT TTG TAT TCT TTC AAT GTC CAT GAG TTA TTG GAC CAA CAC AAC GCT 2169His Leu Tyr Ser Phe Asn Val His Glu Leu Leu Asp Gln His Asn Ala
695 700 705AAC CTA AAA GGA GAA CAC CAT GAG TGATAATGAA CGAACGATTG TAGTTAGAGT 2223Asn Leu Lys Gly Glu His His Glu
710GCTAAAATTT GACCCTCA 2241
(2) Sequence 322 data:
(i) sequence characteristics:
(A) length: 714 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 322: met Lys Ile Thr Tyr Cys Asp Ala Leu Ile Ile Gly Gly Gly Leu Ala 151015 Gly Leu Arg Ala Ser Ile Ala Cys Lys Gln Lys Gly Leu Asn Thr Ile
20 25 30Val Leu Ser Leu Val Pro Val Arg Arg Ser His Ser Ala Ala Ala Gln
35 40 45Gly Gly Met Gln Ala Ser Leu Ala Asn Ala Lys Lys Ser Glu Gly Asp
50 55 60Asn Glu Asp Leu His Phe Leu Asp Thr Val Lys Gly Ser Asp Trp Gly65 70 75 80Cys Asp Gln Gln Val Ala Arg Met Phe Val Thr Thr Ala Pro Lys Ala
85 90 95Ile Arg Glu Leu Ala Ser Trp Gly Val Pro Trp Thr Arg Ile Lys Lys
100 105110Gly Asp Arg Pro Ala Val Val Asn Gly Glu His Val Thr Ile Thr Glu
115 120 125Arg Asp Asp Arg His Gly Tyr Ile Leu Ser Arg Asp Phe Gly Gly Thr
130 135 140Lys Lys Trp Arg Thr Cys Phe Thr Ala Asp Ala Thr Gly His Thr Met145 150 155 160Leu Tyr Ala Val Ala Asn Glu Ala Leu His His Lys Val Asp Ile Gln
165 170 175Asp Arg Lys Asp Met Leu Ala Phe Ile His His Asp Asn Lys Cys Tyr
180 185 190Gly Ala Val Val Arg Asp Leu Ile Thr Gly Glu Ile Ser Ala Tyr Val
195 200 205Ser Lys Gly Thr Leu Leu Ala Thr Gly Gly Tyr Gly Arg Val Tyr Lys
210 215 220His Thr Thr Asn Ala Val Ile Cys Asp Gly Ala Gly Ala Ala Ser Ala225 230 235 240Leu Glu Thr Gly Val Ala Lys Leu Gly Asn Met Glu Ala Val Gln Phe
245 250 255His Pro Thr Ala Leu Val Pro Ser Gly Ile Leu Met Thr Glu Gly Cys
260 265 270Arg Gly Asp Gly Gly Val Leu Arg Asp Lys Phe Gly Arg Arg Phe Met
275 280 285Pro Ala Tyr Glu Pro Glu Lys Lys Glu Leu Ala Ser Arg Asp Val Val
290 295 300Ser Arg Arg Ile Leu Glu His Ile Gln Lys Gly Tyr Gly Ala Lys Ser305 310 315 320Pro Tyr Gly Asp His Val Trp Leu Asp Ile Ala Ile Leu Gly Arg Asn
325 330 335His Val Glu Lys Asn Leu Arg AspVal Arg Asp Ile Ala Met Thr Phe
340 345 350Ala Gly Ile Asp Pro Ala Asp Ser Lys Glu Gln Thr Lys Asp Asn Met
355 360 365Gln Gly Val Pro Ala Asn Glu Pro Glu Tyr Gly Gln Ala Met Ala Lys
370 375 380Gln Lys Gly Trp Ile Pro Ile Lys Pro Met Gln His Tyr Ser Met Gly385 390 395 400Gly Val Arg Thr Asn Pro Lys Gly Glu Thr His Leu Lys Gly Leu Phe
405 410 415Cys Ala Gly Glu Ala Ala Cys Trp Asp Leu His Gly Phe Asn Arg Leu
420 425 430Gly Gly Asn Ser Val Ser Glu Ala Val Val Ala Gly Met Ile Ile Gly
435 440 445Asp Tyr Phe Ala Ser His Cys Leu Glu Ala Gln Ile Glu Ile Asn Thr
450 455 460Gln Lys Val Glu Ala Phe Ile Lys Glu Ser Gln Asp Tyr Met His Phe465 470 475 480Leu Leu His Asn Glu Gly Lys Glu Asp Val Tyr Glu Ile Arg Glu Arg
485 490 495Met Lys Glu Val Met Asp Glu Lys Val Gly Val Phe Arg Glu Gly Lys
500 505 510Arg Leu Glu Glu Ala Leu Lys Glu Leu Gln Glu Leu Tyr Ala Arg Ser
515 520 525Lys Asn Ile Cys Val Lys Asn Lys Val Leu His Asn Asn Pro Glu Leu
530 535 540Glu Asp Ala Tyr Arg Thr Lys Lys Met Leu Lys Leu Ala Leu Cys Ile545 550 555 560Thr Gln Gly Ala Leu Leu Arg Thr Glu Ser Arg GlyAla His Thr Arg
565 570 575Ile Asp Tyr Pro Lys Arg Asp Asp Glu Lys Trp Leu Asn Arg Thr Leu
580 585 590Ala Ser Trp Pro Ser Ala Glu Gln Asp Met Pro Thr Ile Glu Tyr Glu
595 600 605Glu Leu Asp Val Met Lys Met Glu Ile Ser Pro Asp Phe Arg Gly Tyr
610 615 620Gly Lys Lys Gly Asn Phe Ile Pro His Pro Lys Lys Glu Glu Arg Asp625 630 635 640Ala Glu Ile Leu Lys Thr Ile Leu Glu Leu Glu Lys Leu Gly Lys Asp
645 650 655Arg Ile Glu Val Gln His Ala Leu Met Pro Phe Glu Leu Gln Glu Lys
660 665 670Tyr Lys Ala Arg Asn Met Arg Leu Glu Asp Glu Glu Val Arg Ala Arg
675 680 685Gly Glu His Leu Tyr Ser Phe Asn Val His Glu Leu Leu Asp Gln His
690 695 700Asn Ala Asn Leu Lys Gly Glu His His Glu705 710
(2) Sequence 323 data:
(i) sequence characteristics:
(A) length: 496bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 77...445
(D) Other information:
(xi) Description of the sequence: sequence 323: ATTTAGTTCA AGAGCTTTTA GAAGAATTTT TGCAAAGCGG GGCTAAAGAG ATTTTAGAAA 60AGGCGCAGTT GTTTTA ATG CGT TTG TTT ATC GCG CTA GTT TTG TTT TGG TGG 112
Met Arg Leu Phe Ile Ala Leu Val Leu Phe Trp Trp
1 5 10TGG TTA AGC TTG AAC GCT AAA GAA GCG GAT TTT ATC TCT GAT TTA GAA 160Trp Leu Ser Leu Asn Ala Lys Glu Ala Asp Phe Ile Ser Asp Leu Glu
15 20 25TAC GGG ATG GCT CTT TAT AAA AAC CCT AGG GGT GTT GCG TGC GCG AAA 208Tyr Gly Met Ala Leu Tyr Lys Asn Pro Arg Gly Val Ala Cys Ala Lys
30 35 40TGC CAT GGC ATT AAA GGC GAA CAA CAA GAA ATC ACC TTT TAT TAT GAA 256Cys His Gly Ile Lys Gly Glu Gln Gln Glu Ile Thr Phe Tyr Tyr Glu45 50 55 60AAA GGC GAG AAA AAA ATC CTC TAC GCC CCT AAA ATC AAC CAT TTG GAT 304Lys Gly Glu Lys Lys Ile Leu Tyr Ala Pro Lys Ile Asn His Leu Asp
65 70 75TTT AAA ACC TTT AAA GAC GCC TTG AGT TTA GGC AAA GGC ATG ATG CCT 352Phe Lys Thr Phe Lys Asp Ala Leu Ser Leu Gly Lys Gly Met Met Pro
80 85 90AAA TAC AAT CTC AAT TTA GAA GAA ATC CAA GCG ATT TAT CTT TAT ATC 400Lys Tyr Asn Leu Asn Leu Glu Glu Ile Gln Ala Ile Tyr Leu Tyr Ile
95 100 105ATC TCT TTA GAG CAT AAA GAA GAG CGT AAG GAT TCT CCT AAG CCT TAATC 450Ile Ser Leu Glu His Lys Glu Glu Arg Lys Asp Ser Pro Lys Pro
110 115 120AAAGCGCTTG ATTTATGCTA AAATGGAGCG TTGCATTTTT GTTTTG 496
(2) Sequence 324 data:
(i) sequence characteristics:
(A) length: 123 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 324: met Arg Leu Phe Ile Ala Leu Val Leu Phe Trp Trp Trp Leu Ser Leu 151015 Asn Ala Lys Glu Ala Asp Phe Ile Ser Asp Leu Glu Tyr Gly Met Ala
20 25 30Leu Tyr Lys Asn Pro Arg Gly Val Ala Cys Ala Lys Cys His Gly Ile
35 40 45Lys Gly Glu Gln Gln Glu Ile Thr Phe Tyr Tyr Glu Lys Gly Glu Lys
50 55 60Lys Ile Leu Tyr Ala Pro Lys Ile Asn His Leu Asp Phe Lys Thr Phe65 70 75 80Lys Asp Ala Leu Ser Leu Gly Lys Gly Met Met Pro Lys Tyr Asn Leu
85 90 95Asn Leu Glu Glu Ile Gln Ala Ile Tyr Leu Tyr Ile Ile Ser Leu Glu
100 105 110His Lys Glu Glu Arg Lys Asp Ser Pro Lys Pro
115 120
(2) Sequence 325 data:
(i) sequence characteristics:
(A) length: 521bp (bp)
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 72...464
(D) Other information:
(xi) Description of the sequence: sequence 325: GTTGCAACAA AAAATAGAGA GCAGGAAAAC AGACATTGTG ATCCAATCCA TGGCGAATAT 60TCTCAGCGGG A ATG AAT GAG CTT ATC CGC TAT GGC TTG ATA TTT CTC TTT 110
Met Asn Glu Leu Ile Arg Tyr Gly Leu Ile Phe Leu Phe
1 5 10TTT TTA AAG GCG TTT GGG CTT GAT TAT GGG ATA GAT AAA ACG CTA GAA 158Phe Leu Lys Ala Phe Gly Leu Asp Tyr Gly Ile Asp Lys Thr Leu Glu
15 20 25TTA AAA AAA GAT GAA GTG TTT AAA GCG ATC ATC AAA GAC ACT TCA AAT 206Leu Lys Lys Asp Glu Val Phe Lys Ala Ile Ile Lys Asp Thr Ser Asn30 35 40 45GAA CAA ACC AAA GAA ATC ACG CTC TAT TGG ACG CTA TAT GCA AAT AAA 254Glu Gln Thr Lys Glu Ile Thr Leu Tyr Trp Thr Leu Tyr Ala Asn Lys
50 55 60GGT TTA GTC ATC AAC ATG CGT TTT AAC CAT TTC CCT TAC CAG TTT ATT 302Gly Leu Val Ile Asn Met Arg Phe Asn His Phe Pro Tyr Gln Phe Ile
65 70 75TTA TAC ACC GAT CAT GCG AGA AAC ACC TAT AAT CTC AAA GTT TTT GAA 350Leu Tyr Thr Asp His Ala Arg Asn Thr Tyr Asn Leu Lys Val Phe Glu
80 85 90GAA AAA TTT TCT TCT AAC AGC ACT CTG TCG CTT GTG TTT AAA GAT TTT 398Glu Lys Phe Ser Ser Asn Ser Thr Leu Ser Leu Val Phe Lys Asp Phe
95 100 105AAA GAA GAT AAA GCC GCT TTA AGG CTT TTA GCC CTT ATG CCC CTT GTT 446Lys Glu Asp LysAla Ala Leu Arg Leu Leu Ala Leu Met Pro Leu Val110 115 120 125TTT TCT CCT AAA GAG CCT TAAGGAATTT GCATGCAAGA AAAACAACTT AAAACCAT 502Phe Ser Pro Lys Glu Pro
130TCAAAATAAG ATCGCTTCC 521
(2) Sequence 326 data:
(i) sequence characteristics:
(A) length: 131 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 326: met Asn Glu Leu Ile Arg Tyr Gly Leu Ile Phe Leu Phe Phe Leu Lys 151015 Ala Phe Gly Leu Asp Tyr Gly Ile Asp Lys Thr Leu Glu Leu Lys Lys
20 25 30Asp Glu Val Phe Lys Ala Ile Ile Lys Asp Thr Ser Asn Glu Gln Thr
35 40 45Lys Glu Ile Thr Leu Tyr Trp Thr Leu Tyr Ala Asn Lys Gly Leu Val
50 55 60Ile Asn Met Arg Phe Asn His Phe Pro Tyr Gln Phe Ile Leu Tyr Thr65 70 75 80Asp His Ala Arg Asn Thr Tyr Asn Leu Lys Val Phe Glu Glu Lys Phe
85 90 95Ser Ser Asn Ser Thr Leu Ser Leu Val Phe Lys Asp Phe Lys Glu Asp
100 105 110Lys Ala Ala Leu Arg Leu Leu Ala Leu Met Pro Leu Val Phe Ser Pro
115 120 125Lys Glu Pro130
(2) Sequence 327 data:
(i) sequence characteristics:
(A) length: 269bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 55...222
(D) Other information:
(xi) Description of the sequence: sequence 327: GCTCCCTCTA AAAGGGTTTT TAAACTATCT TGAGATTTAC CCAATTTATA GGTG ATG 57
Met
1CTT TCA AAA CTC CCA TTT ACT GGT GTT TTA GCC TTA GTT TTA AAG GCT 105Leu Ser Lys Leu Pro Phe Thr Gly Val Leu Ala Leu Val Leu Lys Ala
5 10 15GTC CAT GTT AGC TTA GCC GAA GAT AAA TCC AAA TTC ACC GCT TGC AAA 153Val His Val Ser Leu Ala Glu Asp Lys Ser Lys Phe Thr Ala Cys Lys
20 25 30AAC CCT GCT AGT AAA ACC GAT ACC AAA ACC ATT TTT TTC ATT CAT TAT 201Asn Pro Ala Ser Lys Thr Asp Thr Lys Thr Ile Phe Phe Ile His Tyr
35 40 45CCT TTA ATG TGG TCT TAT CAA TAACGCTTAT TATTTTAGTG TAAATAAGCA CGCT 256Pro Leu Met Trp Ser Tyr Gln50 55TACAACTAAA ACG 269
(2) Sequence 328 data:
(i) sequence characteristics:
(A) length: 56 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 328: met Leu Ser Lys Leu Pro Phe Thr Gly Val Leu Ala Leu Val Leu Lys 151015 Ala Val His Val Ser Leu Ala Glu Asp Lys Ser Lys Phe Thr Ala Cys
20 25 30Lys Asn Pro Ala Ser Lys Thr Asp Thr Lys Thr Ile Phe Phe Ile His
35 40 45Tyr Pro Leu Met Trp Ser Tyr Gln
50 55
(2) Sequence 329 materials:
(i) sequence characteristics:
(A) length: 671bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 66...611
(D) Other information:
(xi) Description of the sequence: sequence 329: AATGACTTTA GGGGATATTC TTAAAGAAAA ACTCTAAAGA GTGATTTTAA AAGCATGAGA 60ATGGC ATG AGA TTT AAG GGT GTT GTT GCT TTT ATT TCC CTA GCT GTC GCT 110
Met Arg Phe Lys Gly Val Val Ala Phe Ile Ser Leu Ala Val Ala
1 5 10 15CTT GGC GTT TTA GCC TAT TTG TTT TTA AGC GTT AAA AAA GAA ATG CCC 158Leu Gly Val Leu Ala Tyr Leu Phe Leu Ser Val Lys Lys Glu Met Pro
20 25 30GCT ACT TCT CAT GCG ATC TCT CAA ACA CAT GCG ATC TCT CAA ACC AAT 206Ala Thr Ser His Ala Ile Ser Gln Thr His Ala Ile Ser Gln Thr Asn
35 40 45GAA GGC CTC TCT CAA ACA GAT GCA AAA AGC CAT GAC ATC GAT CTA GAA 254Glu Gly Leu Ser Gln Thr Asp Ala Lys Ser His Asp Ile Asp Leu Glu
50 55 60GAA AAT AGC CCC ACT GAA ACC TCT CAT AAT GAA AAA GCC TCC CAT AAC 302Glu Asn Ser Pro Thr Glu Thr Ser His Asn Glu Lys Ala Ser His Asn
65 70 75GAA GAA GAT CAC AAT AAC GCC CTT TCT CAA AAT CTT GAT GCG CAA GAA 350Glu Glu Asp His Asn Asn Ala Leu Ser Gln Asn Leu Asp Ala Gln Glu80 85 90 95TCT ATC AAT TAC CCC GTT GTG GAA CAT TAT TCT GAA ATC CCT TTT GAA 398Ser Ile Asn Tyr Pro Val Val Glu His Tyr Ser Glu Ile Pro Phe Glu
100 105 110GAA AAA AAA AGG GAA TAT TCA AAG CTT ATC ATT AAG GAT TTA AAG GAC 446Glu Lys Lys Arg Glu Tyr Ser Lys Leu Ile Ile Lys Asp Leu Lys Asp
115 120 125TAT CAA TGG TGG TGC TTA AAA GAA ATC CTC AAA AAA GAA CAG ATT GAT 494Tyr Gln Trp Trp Cys Leu Lys Glu Ile Leu Lys Lys Glu Gln Ile Asp
130 135 140TAC GCT TAC GAT AAC ACC AAA AAC CAA CCT AAC CTC ATC ATC TAT TTA 542Tyr Ala Tyr Asp Asn Thr Lys Asn Gln Pro Asn Leu Ile Ile Tyr Leu
145 150 155GAT GAA AAT AAA AAA GAA CGC TTG CTG GCT GAT TTA GAC TAT TAT AAA 590Asp Glu Asn Lys Lys Glu Arg Leu Leu Ala Asp Leu Asp Tyr Tyr Lys160165 170 175ATA CGC TAT CAT GCT GTT TTT TAAATTCAAA GGATAAAAAT GTATCAAGTA GCCA 645Ile Arg Tyr His Ala Val Phe
180TTTGCGACCC CATCCATGCT AAAGGC 671
(2) Sequence 330 data:
(i) sequence characteristics:
(A) length: 182 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 330: met Arg Phe Lys Gly Val Val Ala Phe Ile Ser Leu Ala Val Ala Leu 151015 Gly Val Leu Ala Tyr Leu Phe Leu Ser Val Lys Lys Glu Met Pro Ala
20 25 30Thr Ser His Ala Ile Ser Gln Thr His Ala Ile Ser Gln Thr Asn Glu
35 40 45Gly Leu Ser Gln Thr Asp Ala Lys Ser His Asp Ile Asp Leu Glu Glu
50 55 60Asn Ser Pro Thr Glu Thr Ser His Asn Glu Lys Ala Ser His Asn Glu65 70 75 80Glu Asp His Asn Asn Ala Leu Ser Gln Asn Leu Asp Ala Gln Glu Ser
85 90 95Ile Asn Tyr Pro Val Val Glu His Tyr Ser Glu He Pro Phe Glu Glu
100 105 110Lys Lys Arg Glu Tyr Ser Lys Leu Ile Ile Lys Asp Leu Lys Asp Tyr
115 120 125Gln Trp Trp Cys Leu Lys Glu Ile Leu Lys Lys Glu Gln Ile Asp Tyr
130 135 140Ala Tyr Asp Asn Thr Lys Asn Gln Pro Asn Leu Ile Ile Tyr Leu Asp145 150 155 160Glu Asn Lys Lys Glu Arg Leu Leu Ala Asp Leu Asp Tyr Tyr Lys Ile
165 170 175Arg Tyr His Ala Val Phe
180
(2) Sequence 331 data:
(i) sequence characteristics:
(A) length: 341bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 86...295
(D) Other information:
(xi) Description of the sequence: sequence 331: ACCCACAAAA CTAAAACCCA CTAACACAAT TAACCCTAAC AACACATAAA GATTGCCCAA 60AGACGCGCAC AACACGCTCG CAACA ATG GTT GCA AAA ACA AAC ACA ATC CCC 112
Met Val Ala Lys Thr Asn Thr Ile Pro
1 5CCC ATC GTA GGG GTA TCT TTT TTA TTC TGG TGG CTT GGC ACG AAG CTA 160Pro Ile Val Gly Val Ser Phe Leu Phe Trp Trp Leu Gly Thr Lys Leu10 15 20 25GAA ATG GGC TGG TTA GCC TTT TTA GCC TTG GCC CAT AGA ATG AAT TTA 208Glu Met Gly Trp Leu Ala Phe Leu Ala Leu Ala His Arg Met Asn Leu
30 35 40GGC ATT AAA AAA AGC GTG AGA AAA AAA GCT ATG AAA AAC CCT AAC CCT 256Gly Ile Lys Lys Ser Val Arg Lys Lys AlaMet Lys Asn Pro Asn Pro
45 50 55GCT CTA AAA GTC AAA TAC TGG AAA AGA TTG ATA TTG AAA TAGCCATATA GT 307Ala Leu Lys Val Lys Tyr Trp Lys Arg Leu Ile Leu Lys
60 65 70AAAGAATAGA GCATAAAATC CCCTAAAATC GCCA 341
(2) Sequence 332 data:
(i) sequence characteristics:
(A) length: 70 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 332: met Val Ala Lys Thr Asn Thr Ile Pro Pro Ile Val Gly Val Ser Phe 151015 Leu Phe Trp Trp Leu Gly Thr Lys Leu Glu Met Gly Trp Leu Ala Phe
20 25 30Leu Ala Leu Ala His Arg Met Asn Leu Gly Ile Lys Lys Ser Val Arg
35 40 45Lys Lys Ala Met Lys Asn Pro Asn Pro Ala Leu Lys Val Lys Tyr Trp
50 55 60Lys Arg Leu Ile Leu Lys65 70
(2) Sequence 333 data:
(i) sequence characteristics:
(A) length: 2481bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 58...2430
(D) Other information:
(xi) Description of the sequence: sequence 333: TTTTTTTTTT TTTTTGATTT TTATTTTTTA AATTTTTAGA TTAAGGAGAG TTGTTGG ATG 60
Met
1TTT TTA AGA GTA TAC CCA AAG CTT AGA TAC GCT TTA TGT TTC CCC CTA 108Phe Leu Arg Val Tyr Pro Lys Leu Arg Tyr Ala Leu Cys Phe Pro Leu
5 10 15CTC GCT GAG ACT TGC TAT AGC GAA GAG CGG ACT TTA AAT AAG GTT ACC 156Leu Ala Glu Thr Cys Tyr Ser Glu Glu Arg Thr Leu Asn Lys Val Thr
20 25 30ACC CAA GCT AAA AGG ATT TTC ACT TAC AAC AAT GAG TTT AAA GTA ACT 204Thr Gln Ala Lys Arg Ile Phe Thr Tyr Asn Asn Glu Phe Lys Val Thr
35 40 45TCT AAA GAA CTA GAT CAA CGC CAA AGC AAT GAA GTC AAG GAC TTG TTT 252Ser Lys Glu Leu Asp Gln Arg Gln Ser Asn Glu Val Lys Asp Leu Phe50 55 60 65AGG ACT AAC CCT GAT GTG AAT GTG GGC GGA GGG AGC GTG ATG GGG CAG 300Arg Thr Asn Pro Asp Val Asn Val Gly Gly Gly Ser Val Met Gly Gln
70 75 80AAA ATC TAT GTG AGA GGC GTT GAA GAC AGG CTT TTA AGG GTT ACA GTG 348Lys Ile Tyr Val Arg Gly Val Glu Asp Arg Leu Leu Arg Val Thr Val
85 90 95GAT GGG GCT GCA CAA AAT GGC AAT ATC TAC CAC CAC CAA GGC AAC ACC 396Asp Gly Ala Ala Gln Asn Gly Asn Ile Tyr His His Gln Gly Asn Thr
100105 110GTG ATT GAC CCT GGC ATG CTC AAA AGC GTG GAA GTT ACC AAA GGC GCG 444Val Ile Asp Pro Gly Met Leu Lys Ser Val Glu Val Thr Lys Gly Ala
115 120 125GCG AAT GCG AGC GCG GGG CCA GGA GCG ATT GCG GGA GTG ATT AAA ATG 492Ala Asn Ala Ser Ala Gly Pro Gly Ala Ile Ala Gly Val Ile Lys Met130 135 140 145GAG ACT AAA GGA GCG GCT GAT TTT ATC CCT AGG GGG AAA AAT TAT GCT 540Glu Thr Lys Gly Ala Ala Asp Phe Ile Pro Arg Gly Lys Asn Tyr Ala
150 155 160GCC AGT GGG GCG GTG AGT TTT TAT ACC AAT TTT GGC GAT CGA GAG ACT 588Ala Ser Gly Ala Val Ser Phe Tyr Thr Asn Phe Gly Asp Arg Glu Thr
165 170 175TTC AGA TCG GCT TAT CAA AAC GCG CAT TTT GAT ATT ATC GCT TAC TAC 636Phe Arg Ser Ala Tyr Gln Asn Ala His Phe Asp Ile Ile Ala Tyr Tyr
180 185 190ACG CAC CAA AAC ATC TTC TAT TAT AGA AGC GGC GCT ACA GCG ATG AAA 684Thr His Gln Asn Ile Phe Tyr Tyr Arg Ser Gly Ala Thr Ala Met Lys
195 200 205AAC CTT TTC AAT CCC ACA CAA GCC GAT AAA GAG CCA GGA ACT CCT AGC 732Asn Leu Phe Asn Pro Thr Gln Ala Asp Lys Glu Pro Gly Thr Pro Ser210 215 220 225GAG CAA AAC AAC GCT TTG ATT AAA ATG AAT GGT TAT TTG AGC GAC AGA 780Glu Gln Asn Asn Ala Leu Ile Lys Met Asn Gly Tyr Leu Ser Asp Arg
230 235 240GAC ACG CTC ACT TTC AGC TGG AAC ATG ACA CGA GAT AAC GCT ACA CGC 828Asp Thr Leu Thr Phe Ser Trp Asn Met Thr Arg Asp Asn Ala Thr Arg
245 250 255CCT TTA AGG AGT AAC GCT ATA GGG TTA GCC TAT CCT TGT GAA GCC CCC876Pro Leu Arg Ser Asn Ala Ile Gly Leu Ala Tyr Pro Cys Glu Ala Pro
260 265 270TTT AGT CCT GAT AGT TCT CAA GGG TGT CCT AAT GTG TTA GAT AGT TTC 924Phe Ser Pro Asp Ser Ser Gln Gly Cys Pro Asn Val Leu Asp Ser Phe
275 280 285ACA AGA TAC ATG TAT CAC TCT ATT AAT AGT GCC AAC AAT CTT TCC TTA 972Thr Arg Tyr Met Tyr His Ser Ile Asn Ser Ala Asn Asn Leu Ser Leu290 295 300 305CAA TAC AAA AGG GAA GCG GGA AAT TCT TTT GGC GAC CCA CGA TTA GAT 1020Gln Tyr Lys Arg Glu Ala Gly Asn Ser Phe Gly Asp Pro Arg Leu Asp
310 315 320TTT ACC CTT TAT ACA AGC ATC AGG AAC GCT CAG TTT GAT CCC CTA TTT 1068Phe Thr Leu Tyr Thr Ser Ile Arg Asn Ala Gln Phe Asp Pro Leu Phe
325 330 335GAT CCT AAT GGC GTT TAT GCT AAA TTC CCC ACT TCT TTA GCG AGC GCA 1116Asp Pro Asn Gly Val Tyr Ala Lys Phe Pro Thr Ser Leu Ala Ser Ala
340 345 350TGG GAA AAA GAA AAT TAC CCA TGC GTT GAA GGC GCT TAT TGC ACC CCA 1164Trp Glu Lys Glu Asn Tyr Pro Cys Val Glu Gly Ala Tyr Cys Thr Pro
355 360 365AGC TTT TCA GAT GTG GAT AAA CCA AGC TCA CAG CCT AGG AAT TTG TTT 1212Ser Phe Ser Asp Val Asp Lys Pro Ser Ser Gln Pro Arg Asn Leu Phe370 375 380 385TTA AAC AAC ACC GGC TTA AAC CTT AAA GTC GCG CAT GTG ATT GAT GAA 1260Leu Asn Asn Thr Gly Leu Asn Leu Lys Val Ala His Val Ile Asp Glu
390 395 400GCC ACA GAC AGC CTT TTT GAA TAC GGA TTC AAC TAC CAA AAT TTG AGC 1308Ala Thr Asp Ser Leu Phe Glu Tyr Gly Phe Asn Tyr Gln Asn Leu Ser
405 410 415GTT TTT GAC GCT CGC ATC CCT AAA TCA GAA TTA TAC AGG CCT AAT CAA 1356Val Phe Asp Ala Arg Ile Pro Lys Ser Glu Leu Tyr Arg Pro Asn Gln
420 425 430GTT TAT ACT GAT GAT AAA GGA CAA AAA CAA ATC GCT TGC TCT CTT GTG 1404Val Tyr Thr Asp Asp Lys Gly Gln Lys Gln Ile Ala Cys Ser Leu Val
435 440 445AAT AAT AAC CCC AAT GAC CCC ACT CTG TGC CAA AGA GGG AAA GCG AAC 1452Asn Asn Asn Pro Asn Asp Pro Thr Leu Cys Gln Arg Gly Lys Ala Asn450 455 460 465GGG AAT ATT TAT GGA GGC TAC GTG CAA GCG AAT TAC TCG CCT CAT AAA 1500Gly Asn Ile Tyr Gly Gly Tyr Val Gln Ala Asn Tyr Ser Pro His Lys
470 475 480ATC ATC ACT TTT GGA GCC GGG GTA AGG TGG GAC GCT TAC ACG CTT TAT 1548Ile Ile Thr Phe Gly Ala Gly Val Arg Trp Asp Ala Tyr Thr Leu Tyr
485 490 495GAT AAA GAC TGG AAC CAC CGC TAC ACT CAA GGC TTT AGC CCT AGC GCG 1596Asp Lys Asp Trp Asn His Arg Tyr Thr Gln Gly Phe Ser Pro Ser Ala
500 505 510GCT CTT GTG CTA AGC CCC ATT GAG CCT TTA TCT TTA AAA ATC ACT TAT 1644Ala Leu Val Leu Ser Pro Ile Glu Pro Leu Ser Leu Lys Ile Thr Tyr
515 520 525TCT CAA GTT ACA AGA GGG GTG ATG CCA GGA GAT GGC GTG TAC ATG CGT 1692Ser Gln Val Thr Arg Gly Val Met Pro Gly Asp Gly Val Tyr Met Arg530 535 540 545CAA AAC GAT TTA CGA TAC GCC AAA AAC ATC AAG CCT GAA GTG GGC TCT 1740Gln Asn Asp Leu Arg Tyr Ala Lys Asn Ile Lys Pro Glu Val Gly Ser
550 555 560AAC GCT GAA TTT AAT ATT GAT TAT TCAAGC CAG TAT TTT AGC GGG AGG 1788Asn Ala Glu Phe Asn Ile Asp Tyr Ser Ser Gln Tyr Phe Ser Gly Arg
565 570 575GCT GCG GCG TTT TAT CAG GCT TTG GAT AAT TTC ATC TCA CAA TAC GCA 1836Ala Ala Ala Phe Tyr Gln Ala Leu Asp Asn Phe Ile Ser Gln Tyr Ala
580 585 590CAA AAT TTG ATT GTA ACC AAT TTG AGT CAA GCG ATT CGT ATT TAT GGC 1884Gln Asn Leu Ile Val Thr Asn Leu Ser Gln Ala Ile Arg Ile Tyr Gly
595 600 605TAT GAA GTG GGT GGG ACT TTC AGA TAC AAG GGC GTG AGT TTG AAT GTA 1932Tyr Glu Val Gly Gly Thr Phe Arg Tyr Lys Gly Val Ser Leu Asn Val610 615 620 625GGG GTC TCG CGC ACC TGG CCC ACC ACT AGG GGG TAT TTA ATG GCG GAT 1980Gly Val Ser Arg Thr Trp Pro Thr Thr Arg Gly Tyr Leu Met Ala Asp
630 635 640AGC TAT GAG CTT GCC GCA AGC ACC GGT AAT GTT TTT ATC ATC AAA TTG 2028Ser Tyr Glu Leu Ala Ala Ser Thr Gly Asn Val Phe Ile Ile Lys Leu
645 650 655GAT TAC ACC ATC CCC AAA ACA GGG ATC AAT CTT GCA TGG CTT AGC CGC 2076Asp Tyr Thr Ile Pro Lys Thr Gly Ile Asn Leu Ala Trp Leu Ser Arg
660 665 670TTT GTT ACC GGT TTA GAT TAT TGC GGG TTT GAT ATT TAC TTG CCT GAT 2124Phe Val Thr Gly Leu Asp Tyr Cys Gly Phe Asp Ile Tyr Leu Pro Asp
675 680 685TAT GGG ACG GCT GAG AAA CCC AAA ACC CCT ACC GAT TTA GCC AAA TGC 2172Tyr Gly Thr Ala Glu Lys Pro Lys Thr Pro Thr Asp Leu Ala Lys Cys690 695 700 705GGA TCT CAA TTA GGG TTA GTG CAT ATG CAT AAA CCG GGC TAT GGC GTG 2220Gly Ser Gln Leu Gly Leu Val His Met His Lys Pro Gly Tyr Gly Val
710 715 720AGT AAT TTT TAT ATC AAT TGG AGT CCT AAA ACC AAA AGC CGC TGG AAG 2268Ser Asn Phe Tyr Ile Asn Trp Ser Pro Lys Thr Lys Ser Arg Trp Lys
725 730 735GGT TTG TTG CTT TCA GCC GTG TTT AAT AAT GTT TTC AAC AAA TTC TAT 2316Gly Leu Leu Leu Ser Ala Val Phe Asn Asn Val Phe Asn Lys Phe Tyr
740 745 750GTG GAT CAA ACA AGC CCT TAT GTC ATG AGC CCG GAT ATG CCA GGC ACT 2364Val Asp Gln Thr Ser Pro Tyr Val Met Ser Pro Asp Met Pro Gly Thr
755 760 765GAC GCT GTT AAA AGA GCG ATC GCT GAG CCT GGG TTT AAC GCG CGT TTT 2412Asp Ala Val Lys Arg Ala Ile Ala Glu Pro Gly Phe Asn Ala Arg Phe770 775 780 785GAA GTG GCT TAC AAA TGG TAGTTAATGG AGCTTTAAGC GTTGCGCATG CGTGATAG 2468Glu Val Ala Tyr Lys Trp
790CAACGGCTAT CGC 2481
(2) Sequence 334 data:
(i) sequence characteristics:
(A) length: 791 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 334: met Phe Leu Arg Val Tyr Pro Lys Leu Arg Tyr Ala Leu Cys Phe Pro 151015 Leu Leu Ala Glu Thr Cys Tyr Ser Glu Glu Arg Thr Leu Asn Lys Val
20 25 30Thr Thr Gln Ala Lys Arg Ile Phe Thr Tyr Asn Asn Glu Phe Lys Val
35 40 45Thr Ser Lys Glu Leu Asp Gln Arg Gln Ser Asn Glu Val Lys Asp Leu
50 55 60Phe Arg Thr Asn Pro Asp Val Asn Val Gly Gly Gly Ser Val Met Gly65 70 75 80Gln Lys Ile Tyr Val Arg Gly Val Glu Asp Arg Leu Leu Arg Val Thr
85 90 95Val Asp Gly Ala Ala Gln Asn Gly Asn Ile Tyr His His Gln Gly Asn
100 105 110Thr Val Ile Asp Pro Gly Met Leu Lys Ser Val Glu Val Thr Lys Gly
115 120 125Ala Ala Asn Ala Ser Ala Gly Pro Gly Ala Ile Ala Gly Val Ilo Lys
130 135 140Met Glu Thr Lys Gly Ala Ala Asp Phe Ile Pro Arg Gly Lys Asn Tyr145 150 155 160Ala Ala Ser Gly Ala Val Ser Phe Tyr Thr Asn Phe Gly Asp Arg Glu
165 170 175Thr Phe Arg Ser Ala Tyr Gln Asn Ala His Phe Asp Ile Ile Ala Tyr
180 185 190Tyr Thr His Gln Asn Ile Phe Tyr Tyr Arg Ser Gly Ala Thr Ala Met
195 200 205Lys Asn Leu Phe Asn Pro Thr Gln Ala Asp Lys Glu Pro Gly Thr Pro
210 215 220Ser Glu Gln Asn Asn Ala Leu Ile Lys Met Asn Gly Tyr Leu Ser Asp225 230 235 240Arg Asp Thr Leu Thr Phe Ser Trp Asn Met Thr Arg Asp Asn Ala Thr
245 250 255Arg Pro Leu Arg Ser Asn Ala Ile Gly Leu Ala Tyr Pro Cys Glu Ala
260265 270Pro Phe Ser Pro Asp Ser Ser Gln Gly Cys Pro Asn Val Leu Asp Ser
275 280 285Phe Thr Arg Tyr Met Tyr His Ser Ile Asn Ser Ala Asn Asn Leu Ser
290 295 300Leu Gln Tyr Lys Arg Glu Ala Gly Asn Ser Phe Gly Asp Pro Arg Leu305 310 315 320Asp Phe Thr Leu Tyr Thr Ser Ile Arg Asn Ala Gln Phe Asp Pro Leu
325 330 335Phe Asp Pro Asn Gly Val Tyr Ala Lys Phe Pro Thr Ser Leu Ala Ser
340 345 350Ala Trp Glu Lys Glu Asn Tyr Pro Cys Val Glu Gly Ala Tyr Cys Thr
355 360 365Pro Ser Phe Ser Asp Val Asp Lys Pro Ser Ser Gln Pro Arg Asn Leu
370 375 380Phe Leu Asn Asn Thr Gly Leu Asn Leu Lys Val Ala His Val Ile Asp385 390 395 400Glu Ala Thr Asp Ser Leu Phe Glu Tyr Gly Phe Asn Tyr Gln Asn Leu
405 410 415Ser Val Phe Asp Ala Arg Ile Pro Lys Ser Glu Leu Tyr Arg Pro Asn
420 425 430Gln Val Tyr Thr Asp Asp Lys Gly Gln Lys Gln Ile Ala Cys Ser Leu
435 440 445Val Asn Asn Asn Pro Asn Asp Pro Thr Leu Cys Gln Arg Gly Lys Ala
450 455 460Asn Gly Asn Ile Tyr Gly Gly Tyr Val Gln Ala Asn Tyr Ser Pro His465 470 475 480Lys Ile Ile Thr Phe Gly Ala Gly Val Arg Trp Asp Ala Tyr Thr Leu
485 490 495Tyr Asp Lys Asp Trp Asn His Arg Tyr Thr Gln Gly Phe Ser Pro Ser
500 505 510Ala Ala Leu Val Leu Ser Pro Ile Glu Pro Leu Ser Leu Lys Ile Thr
515 520 525Tyr Ser Gln Val Thr Arg Gly Val Met Pro Gly Asp Gly Val Tyr Met
530 535 540Arg Gln Asn Asp Leu Arg Tyr Ala Lys Asn Ile Lys Pro Glu Val Gly545 550 555 560Ser Asn Ala Glu Phe Asn Ile Asp Tyr Ser Ser Gln Tyr Phe Ser Gly
565 570 575Arg Ala Ala Ala Phe Tyr Gln Ala Leu Asp Asn Phe Ile Ser Gln Tyr
580 585 590Ala Gln Asn Leu Ile Val Thr Asn Leu Ser Gln Ala Ile Arg Ile Tyr
595 600 605Gly Tyr Glu Val Gly Gly Thr Phe Arg Tyr Lys Gly Val Ser Leu Asn
610 615 620Val Gly Val Ser Arg Thr Trp Pro Thr Thr Arg Gly Tyr Leu Met Ala625 630 635 640Asp Ser Tyr Glu Leu Ala Ala Ser Thr Gly Asn Val Phe Ile Ile Lys
645 650 655Leu Asp Tyr Thr Ile Pro Lys Thr Gly Ile Asn Leu Ala Trp Leu Ser
660 665 670Arg Phe Val Thr Gly Leu Asp Tyr Cys Gly Phe Asp Ile Tyr Leu Pro
675 680 685Asp Tyr Gly Thr Ala Glu Lys Pro Lys Thr Pro Thr Asp Leu Ala Lys
690 695 700Cys Gly Ser Gln Leu Gly Leu Val His Met His Lys Pro Gly Tyr Gly705 710 715 720Val Ser Asn Phe Tyr Ile AsnTrp Ser Pro Lys Thr Lys Ser Arg Trp
725 730 735Lys Gly Leu Leu Leu Ser Ala Val Phe Asn Asn Val Phe Asn Lys Phe
740 745 750Tyr Val Asp Gln Thr Ser Pro Tyr Val Met Ser Pro Asp Met Pro Gly
755 760 765Thr Asp Ala Val Lys Arg Ala Ile Ala Glu Pro Gly Phe Asn Ala Arg
770 775 780Phe Glu ValAla Tyr Lys Trp785 790
(2) Sequence 335 data:
(i) sequence characteristics:
(A) length: 47bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 120...428
(D) Other information:
(xi) Description of the sequence: sequence 335: GTCGGTCGGG TAATGTTCAA ATTCACAAAT GAGTCTGAAG ACAAAGAAGT CTTGATCTAG 60AAGCCGAAAT TCTCATACCG CACTTAGAAT TGCGTCAAAA ACAAATTGAT GCGCTGTTG 119GTG CAC GAT ATT ACC AAG CTA TGT TAC ACC AAA CCA CTA GGG TGT GTT 167Val His Asp Ile Thr Lys Leu Cys Tyr Thr Lys Pro Leu Gly Cys Val 151015 GTG CTG TTC AGC AAG GAT ACT GAT CTT GTG CCT GTG TTA GAA TCC GCT 215Val Leu Phe Ser Lys Asp Thr Asp Leu Val Pro Val Leu Glu Ser Ala
20 25 30TGG GAG AAA GGC TTT GAA GTC TTC ATT GCT AAC ATT CAA GAA TGC CCC 263Trp Glu Lys Gly Phe Glu Val Phe Ile Ala Asn Ile Gln Glu Cys Pro
35 40 45AAT TCT GTC CCT TCA GAC TTG AAG AAG TCT TGC AAT GTG AGG GAA CGC 311Asn Ser Val Pro Ser Asp Leu Lys Lys Ser Cys Asn Val Arg Glu Arg
50 55 60AGT GTC GCT GAA ATT GTA GAT AAC TTG CCC AAA AAT CAG CAC ACT CCC 359Ser Val Ala Glu Ile Val Asp Asn Leu Pro Lys Asn Gln His Thr Pro65 70 75 80AAG AAA AAG AAC TTT TCC ACC AAC GAG CCT TTT AAC AAC CCA TTT AAA 407Lys Lys Lys Asn Phe Ser Thr Asn Glu Pro Phe Asn Asn Pro Phe Lys
85 90 95GAC CAA CTC TTT AAG AAG AAC TAACACGATC CCCACACCAA GGGGACAAAA AAGCA 463Asp Gln Leu Phe Lys Lys Asn
100CCCATTTTAA AAGG 477
(2) Sequence 336 data:
(i) sequence characteristics:
(A) length: 103 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 336: val His Asp Ile Thr Lys Leu Cys Tyr Thr Lys Pro Leu Gly Cys Val 151015 Val Leu Phe Ser Lys Asp Thr Asp Leu Val Pro Val Leu Glu Ser Ala
20 25 30Trp Glu Lys Gly Phe Glu Val Phe Ile Ala Asn Ile Gln Glu Cys Pro
35 40 45Asn Ser Val Pro Ser Asp Leu Lys Lys Ser Cys Asn Val Arg Glu Arg
50 55 60Ser Val Ala Glu Ile Val Asp Asn Leu Pro Lys Asn Gln His Thr Pro65 70 75 80Lys Lys Lys Asn Phe Ser Thr Asn Glu Pro Phe Asn Asn Pro Phe Lys
85 90 95Asp Gln Leu Phe Lys Lys Asn
100
(2) Sequence 337 data:
(i) sequence characteristics:
(A) length: 685bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 220...624
(D) Other information:
(xi) Description of the sequence: sequence 337: TCTTTTGAAA TTGCCTGATG TGGAAAAAGA AATGCCCAAA GAGACGACTC AAAAAAGCTT 60GTTTTCGCAC AAACACTTTG TTTTTGGGGC TTGGGGATCT TTTTTTATGT GGGGGGAGAA 120NTGGCGATTG GCTCATTCTT GGTGCTAAGC TTTGAAAAGC TTTTGAATTT AGACTCTCAA 180TCAAGCGCGC ATTACTTGGT GTATTATTGG GGAGGCGCG ATG GTG GGC CGT TTC 234
Met Val Gly Arg Phe
1 5TTA GGC AGT GTG TTG ATG AAT AAA ATT GCC CCT AAT AAA TAC TTG GCT 282Leu Gly Ser Val Leu Met Asn Lys Ile Ala Pro Asn Lys Tyr Leu Ala
10 15 20TTC AAC GCC TTA AGC TCT ATT GTT CTC ATC GCT TTA GCC ATT ATC ATT 330Phe Asn Ala Leu Ser Ser Ile Val Leu Ile Ala Leu Ala Ile Ile Ile
25 3035GGA GGC AAG ATC GCT TTA TTC GCT CTG ACT TTT GTG GGC TTT TTC AAC 378Gly Gly Lys Ile Ala Leu Phe Ala Leu Thr Phe Val Gly Phe Phe Asn
40 45 50TCT ATC ATG TTC CCT ACC ATC TTT TCT TTG GCT ACG CTC AAT TTA GGG 426Ser Ile Met Phe Pro Thr Ile Phe Ser Leu Ala Thr Leu Asn Leu Gly
55 60 65CAT CTC ACT TCT AAA GCT TCT GGG GTG ATT AGC ATG GCG ATT GTG GGA 474His Leu Thr Ser Lys Ala Ser Gly Val Ile Ser Met Ala Ile Val Gly70 75 80 85GGG GCG TTA ATC CCC CCC ATT CAA GGT GCG GTT ACA GAC ATG CTA ACA 522Gly Ala Leu Ile Pro Pro Ile Gln Gly Ala Val Thr Asp Met Leu Thr
90 95 100GCA ACC GAA TCA AAT TTG CTC TAC GCT TAT GGT GTG CCG TTG TTG TGC 570Ala Thr Glu Ser Asn Leu Leu Tyr Ala Tyr Gly Val Pro Leu Leu Cys
105 110 115TAT TTT TAT ATT CTC TTC TTT GCG CTT AAA GGG TAT AAG CAA GAA GAA 618Tyr Phe Tyr Ile Leu Phe Phe Ala Leu Lys Gly Tyr Lys Gln Glu Glu
120 125 130AAC TCC TAAAAAAAGG GGGGGTTTCT TTCTTCTTTC CTTTCTTTTA TCTTGTTTTA AA 676Asn Ser
135AATCAGTAA 685
(2) Sequence 338 data:
(i) sequence characteristics:
(A) length: 135 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 338: met Val Gly Arg Phe Leu Gly Ser Val Leu Met Asn Lys Ile Ala Pro 151015 Asn Lys Tyr Leu Ala Phe Asn Ala Leu Ser Ser Ile Val Leu Ile Ala
20 25 30Leu Ala Ile Ile Ile Gly Gly Lys Ile Ala Leu Phe Ala Leu Thr Phe
35 40 45Val Gly Phe Phe Asn Ser Ile Met Phe Pro Thr Ile Phe Ser Leu Ala
50 55 60Thr Leu Asn Leu Gly His Leu Thr Ser Lys Ala Ser Gly Val Ile Ser65 70 75 80Met Ala Ile Val Gly Gly Ala Leu Ile Pro Pro Ile Gln Gly Ala Val
85 90 95Thr Asp Met Leu Thr Ala Thr Glu Ser Asn Leu Leu Tyr Ala Tyr Gly
100 105 110Val Pro Leu Leu Cys Tyr Phe Tyr Ile Leu Phe Phe Ala Leu Lys Gly
115 120 125Tyr Lys Gln Glu Glu Asn Ser
130 135
(2) Sequence 339 data:
(i) sequence characteristics:
(A) length: 809bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 58...765
(D) Other information:
(xi) Description of the sequence: sequence 339: ACCGATCACT AAAACCAATG TAACTTACCG CTCTTTACAG CGTAAGTGAG AAAAGGA ATG 60
Met
1CAT TTG AAT ACG GAT TTT AGC CAT ATC ACC GAT ATA GAG GGC ATG CGT 108His Leu Asn Thr Asp Phe Ser His Ile Thr Asp Ile Glu Gly Met Arg
5 10 15TTT ATC AAT GAA GAA GAC GCT TTG AAC AAA TTG ATT AAT GAA ATC CAC 156Phe Ile Asn Glu Glu Asp Ala Leu Asn Lys Leu Ile Asn Glu Ile His
20 25 30ACG CGC CAC ATT GAT TTA AAA GAT TCC ATC ATG CTC GCT TTG AGT TTT 204Thr Arg His Ile Asp Leu Lys Asp Ser Ile Met Leu Ala Leu Ser Phe
35 40 45AAC GCT CTG TAT TTA GCT CAC GCT TTA GCG CAA AAA TTT GGA GCG ACT 252Asn Ala Leu Tyr Leu Ala His Ala Leu Ala Gln Lys Phe Gly Ala Thr50 55 60 65TAT GAT ATA CTT TTT TTA GAA CCT ATC CTA GCC CCT TTA AAC TCA AAA 300Tyr Asp Ile Leu Phe Leu Glu Pro Ile Leu Ala Pro Leu Asn Ser Lys
70 75 80TGC GAG ATC GCT TTA GTG AGT GAG AGC ATG GAT ATA GTG ATG AAT GAA 348Cys Glu Ile Ala Leu Val Ser Glu Ser Met Asp Ile Val Met Asn Glu
85 90 95AGT TTG ATC AAT TCC TTT GAC ATC ACT TTA GAC TAT GTT TAT GGG GAA 396Ser Leu Ile Asn Ser Phe Asp Ile Thr Leu Asp Tyr Val Tyr Gly Glu
100 105 110GCC AAG CGA GCT TAT GAA GAA GAC ATT TTG TCT CAC ATC TAT CAG TAT 444Ala Lys Arg Ala Tyr Glu Glu Asp Ile Leu Ser His Ile Tyr Gln Tyr
115 120 125CGC AAA GGC AAT GCG ATC AAA AGC TTA AAA GAT AAA AAT ATT TTTATC 492Arg Lys Gly Asn Ala Ile Lys Ser Leu Lys Asp Lys Asn Ile Phe Ile130 135 140 145GTA GAT AGG GGG ATT GAA ACC GGG TTT AGA GCA GGG TTA GGC GTG CAA 540Val Asp Arg Gly Ile Glu Thr Gly Phe Arg Ala Gly Leu Gly Val Gln
150 155 160ACT TGC TTG AAA AAA GAA TGC CAA GAC ATT TAT ATT TTA ACC CCC ATT 588Thr Cys Leu Lys Lys Glu Cys Gln Asp Ile Tyr Ile Leu Thr Pro Ile
165 170 175GTC GCG CAA AAT GTC GCT CAA GGC TTA GAA AGT TTG TGC GAT GGG GTG 636Val Ala Gln Asn Val Ala Gln Gly Leu Glu Ser Leu Cys Asp Gly Val
180 185 190ATT AGT GTG TAT CGC CCT GAA TGT TTT GTC TCT GTG GAG CAT CAT TAT 684Ile Ser Val Tyr Arg Pro Glu Cys Phe Val Ser Val Glu His His Tyr
195 200 205AAA GAA CTC AAG CGA TTA AGC AAT GAA GAA GTT GAA AAA TAC TTG GGC 732Lys Glu Leu Lys Arg Leu Ser Asn Glu Glu Val Glu Lys Tyr Leu Gly210 215 220 225GCT AAC AAC ATG CCT AAT TTA AAA AAG GAA CAT TAAATATGGA TTTTATCACC 785Ala Asn Asn Met Pro Asn Leu Lys Lys Glu His
230 235ATCAATTCTA GTAACAAAAC CGAA 809
(2) Sequence 340 data:
(i) sequence characteristics:
(A) length: 236 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description ofthe sequence: sequence 340: met His Leu Asn Thr Asp Phe Ser His Ile Thr Asp Ile Glu Gly Met 151015 Arg Phe Ile Asn Glu Glu Asp Ala Leu Asn Lys Leu Ile Asn Glu Ile
20 25 30His Thr Arg His Ile Asp Leu Lys Asp Ser Ile Met Leu Ala Leu Ser
35 40 45Phe Asn Ala Leu Tyr Leu Ala His Ala Leu Ala Gln Lys Phe Gly Ala
50 55 60Thr Tyr Asp Ile Leu Phe Leu Glu Pro Ile Leu Ala Pro Leu Asn Ser65 70 75 80Lys Cys Glu Ile Ala Leu Val Ser Glu Ser Met Asp Ile Val Met Asn
85 90 95Glu Ser Leu Ile Asn Ser Phe Asp Ile Thr Leu Asp Tyr Val Tyr Gly
100 105 110Glu Ala Lys Arg Ala Tyr Glu Glu Asp Ile Leu Ser His Ile Tyr Gln
115 120 125Tyr Arg Lys Gly Asn Ala Ile Lys Ser Leu Lys Asp Lys Asn Ile Phe
130 135 140Ile Val Asp Arg Gly Ile Glu Thr Gly Phe Arg Ala Gly Leu Gly Val145 150 155 160Gln Thr Cys Leu Lys Lys Glu Cys Gln Asp Ile Tyr Ile Leu Thr Pro
165 170 175Ile Val Ala Gln Asn Val Ala Gln Gly Leu Glu Ser Leu Cys Asp Gly
180 185 190Val Ile Ser Val Tyr Arg Pro Glu Cys Phe Val Ser Val Glu His His
195 200 205Tyr Lys Glu Leu Lys Arg Leu Ser Asn Glu Glu Val Glu Lys Tyr Leu
210 215 220Gly Ala Asn Asn Met Pro Asn Leu Lys Lys Glu His225 230 235
(2) Sequence 341 data:
(i) sequence characteristics:
(A) length: 325bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...285
(D) Other information:
(xi) Description of the sequence: sequence 341: TAACACAAGC CACCATGAGC ATACTATCGC CATAGTTGGC AATAAAGCAG TGATTCTTAC 60GGAGCGTTA ATG GCA AGA GAT GAT GTT ATA GAA GTG GAT GGG AAA GTG ATT 111
Met Ala Arg Asp Asp Val Ile Glu Val Asp Gly Lys Val Ile
1 5 10GAG GCG TTG CCT AAC GCT ACT TTT AAG GTG GAG TTA GAC AAT AAG CAT 159Glu Ala Leu Pro Asn Ala Thr Phe Lys Val Glu Leu Asp Asn Lys His15 20 25 30GTG GTG TTG TGC CGT ATT TCT GGA AAG ATG CGC ATG CAC TAT ATT AGG 207Val Val Leu Cys Arg Ile Ser Gly Lys Met Arg Met His Tyr Ile Arg
35 40 45ATT GCT TTA GGC GAT AGG GTT AAG CTA GAG CTT ACG CCC TAT AGC TTA 255Ile Ala Leu Gly Asp Arg Val Lys Leu Glu Leu Thr Pro Tyr Ser Leu
50 55 60GAC AAA GGT CGG ATA ACT TTT AGA TAT AAA TGAATTTAAG GGTTATTTCA ATG 308Asp Lys Gly Arg Ile Thr Phe Arg Tyr Lys
65 70AAAATATGTT AATATAA 325
(2) Sequence 342 data:
(i) sequence characteristics:
(A) length: 72 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 342: met Ala Arg Asp Asp Val Ile Glu Val Asp Gly Lys Val Ile Glu Ala 151015 Leu Pro Asn Ala Thr Phe Lys Val Glu Leu Asp Asn Lys His Val Val
20 25 30Leu Cys Arg Ile Ser Gly Lys Met Arg Met His Tyr Ile Arg Ile Ala
35 40 45Leu Gly Asp Arg Val Lys Leu Glu Leu Thr Pro Tyr Ser Leu Asp Lys
50 55 60Gly Arg Ile Thr Phe Arg Tyr Lys65 70
(2) Sequence 343 data:
(i) sequence characteristics:
(A) length: 360bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...309
(D) Other information:
(xi) Description of the sequence: sequence 343: ATCGCTCAAA TTTCAACGAC CATGCTTGTT AAAAAAAACT AAAGGAATGT T ATG GAA 57
Met Gln
1GAT GAA TTA TTT GAA ACC GAA AAA ATC CCC CCA AAA AAC ACT AAA AAT 105Asp Glu Leu Phe Glu Thr Glu Lys Ile Pro Pro Lys Asn Thr Lys Asn
5 10 15ACT AAA AAC GCC CCT AAA AAA AGT TTT GAA GAG CAT GTT CAT TCC CTA 153Thr Lys Asn Ala Pro Lys Lys Ser Phe Glu Glu His Val His Ser Leu
20 25 30GAG CGA GCC ATA GAT CGC TTG AAT GAT CCC AAT TTA TCC TTA AAA GAC 201Glu Arg Ala Ile Asp Arg Leu Asn Asp Pro Asn Leu Ser Leu Lys Asp35 40 45 50GGG ATG GAT TTG TAT AAA ACG GCC ATG CAA GAG TTG TTT TTG GCT CAA 249Gly Met Asp Leu Tyr Lys Thr Ala Met Gln Glu Leu Phe Leu Ala Gln
55 60 65AAG CTT TTA GAA AAC GCT TAT TTA GAG CAT GAA AAA CTC CAA ACG CCA 297Lys Leu Leu Glu Asn Ala Tyr Leu Glu His Glu Lys Leu Gln Thr Pro
70 75 80GAC CAA AAG GCT TAAAGCATGC GAGTGTTTGC TTTGCAATTA GAATCTTTTA AAGAA 354Asp Gln Lys Ala
85AATCTC 360
(2) Sequence 344 data:
(i) sequence characteristics:
(A) length: 86 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(II) type of molecule: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 344: met GlnAsp Glu Leu Phe Glu Thr Glu Lys Ile Pro Pro Lys Asn Thr 151015 Lys Asn Thr Lys Asn Ala Pro Lys Lys Ser Phe Glu Glu His Val His
20 25 30Ser Leu Glu Arg Ala Ile Asp Arg Leu Asn Asp Pro Asn Leu Ser Leu
35 40 45Lys Asp Gly Met Asp Leu Tyr Lys Thr Ala Met Gln Glu Leu Phe Leu
50 55 60Ala Gln Lys Leu Leu Glu Asn Ala Tyr Leu Glu His Glu Lys Leu Gln65 70 75 80Thr Pro Asp Gln Lys Ala
85
(2) Sequence 345 data:
(i) sequence characteristics:
(A) length: 841bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 46...795
(D) Other information:
(xi) Description of the sequence: sequence 345: ATGACTAAAA AGATATAATT CATTCAAAAT TAAACAAGGA TTACA ATG AAA CTG ATT 57
Met Lys Leu Ile
1TCA TGG AAT GTG AAC GGG TTA AGG GCT TGC ATG ACT AAG GGC TTT ATG 105Ser Trp Asn Val Asn Gly Leu Arg Ala Cys Met Thr Lys Gly Phe Met 5 10 15 20GAT TTT TTC AAT AGC GTT GAT GCG GAT GTT TTT TGC ATT CAA GAA TCT 153Asp Phe Phe Asn Ser Val Asp Ala Asp ValPhe Cys Ile Gln Glu Ser
25 30 35AAA ATG CAG CAA GAA CAA AAC ACC TTT GAA TTT AAA GGG TAT TTT GAT 201Lys Met Gln Gln Glu Gln Asn Thr Phe Glu Phe Lys Gly Tyr Phe Asp
40 45 50TTT TGG AAT TGC GCG ATT AAA AAG GGC TAT TCT GGG GTG GTA ACT TTC 249Phe Trp Asn Cys Ala Ile Lys Lys Gly Tyr Ser Gly Val Val Thr Phe
55 60 65ACT AAA AAA GAG CCT TTA AGC GTG AGC TAT GGT ATT AAT ATG GAA GAG 297Thr Lys Lys Glu Pro Leu Ser Val Ser Tyr Gly Ile Asn Met Glu Glu
70 75 80CAT GAC AAA GAA GGG CGC GTA ATA ACT TGC GAA TTT GAG TCG TTT TAT 345His Asp Lys Glu Gly Arg Val Ile Thr Cys Glu Phe Glu Ser Phe Tyr85 90 95 100TTG GTG AAT GTT TAT ACC CCT AAT TCC CAA CAA GCC CTA TCC AGG CTT 393Leu Val Asn Val Tyr Thr Pro Asn Ser Gln Gln Ala Leu Ser Arg Leu
105 110 115AGT TAT CGC ATG AGT TGG GAA GTG GAG TTT AAG AAA TTT TTA AAA GCT 441Ser Tyr Arg Met Ser Trp Glu Val Glu Phe Lys Lys Phe Leu Lys Ala
120 125 130TTA GAG TTG AAA AAA CCG GTC ATT GTG TGT GGG GAT TTG AAT GTG GCT 489Leu Glu Leu Lys Lys Pro Val Ile Val Cys Gly Asp Leu Asn Val Ala
135 140 145CAC AAT GAA ATT GAT TTA GAA AAC CCC AAA ACC AAC CGA AAA AAT GCC 537His Asn Glu Ile Asp Leu Glu Asn Pro Lys Thr Asn Arg Lys Asn Ala
150 155 160GGC TTT AGC GAT GAA GAG AGA GAA AAA TTC AGC GAG CTT TTG AAC GCC 585Gly Phe Ser Asp Glu Glu Arg Glu Lys Phe Ser Glu Leu Leu Asn Ala165 170 175180GGT TTT ATT GAC ACT TTC CGT TAT TTT TAC CCT AAC AAA GAA AAG GCT 633Gly Phe Ile Asp Thr Phe Arg Tyr Phe Tyr Pro Asn Lys Glu Lys Ala
185 190 195TAC ACC TGG TGG AGT TAC ATG CAA CAA GCA AGG GAT AAA AAC ATT GGT 681Tyr Thr Trp Trp Ser Tyr Met Gln Gln Ala Arg Asp Lys Asn Ile Gly
200 205 210TGG CGC ATT GAT TAT TTT TTA TGC TCT AAC CCT TTA AAA ACG CGC TTA 729Trp Arg Ile Asp Tyr Phe Leu Cys Ser Asn Pro Leu Lys Thr Arg Leu
215 220 225AAA GAC GCT TTA ATC TAT AAA GAT ATT TTA GGG AGC GAT CAT TGC CCG 777Lys Asp Ala Leu Ile Tyr Lys Asp Ile Leu Gly Ser Asp His Cys Pro
230 235 240GTA GGG TTG GAA TTA GTT TAAAGGTAGA AAGTGTGCGA AATAAAGACA GAAAAAAG 833Val Gly Leu Glu Leu Val245 250CCTTACAA 841
(2) Sequence 346 data:
(i) sequence characteristics:
(A) length: 250 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 346: met Lys Leu Ile Ser Trp Asn Val Asn Gly Leu Arg Ala Cys Met Thr 151015 Lys Gly Phe Met Asp Phe Phe Asn Ser Val Asp Ala Asp Val Phe Cys
20 25 30Ile Gln Glu Ser Lys Met Gln Gln Glu Gln Asn Thr Phe Glu Phe Lys
35 4045Gly Tyr Phe Asp Phe Trp Asn Cys Ala Ile Lys Lys Gly Tyr Ser Gly
50 55 60Val Val Thr Phe Thr Lys Lys Glu Pro Leu Ser Val Ser Tyr Gly Ile65 70 75 80Asn Met Glu Glu His Asp Lys Glu Gly Arg Val Ile Thr Cys Glu Phe
85 90 95Glu Ser Phe Tyr Leu Val Asn Val Tyr Thr Pro Asn Ser Gln Gln Ala
100 105 110Leu Ser Arg Leu Ser Tyr Arg Met Ser Trp Glu Val Glu Phe Lys Lys
115 120 125Phe Leu Lys Ala Leu Glu Leu Lys Lys Pro Val Ile Val Cys Gly Asp
130 135 140Leu Asn Val Ala His Asn Glu Ile Asp Leu Glu Asn Pro Lys Thr Asn145 150 155 160Arg Lys Asn Ala Gly Phe Ser Asp Glu Glu Arg Glu Lys Phe Ser Glu
165 170 175Leu Leu Asn Ala Gly Phe Ile Asp Thr Phe Arg Tyr Phe Tyr Pro Asn
180 185 190Lys Glu Lys Ala Tyr Thr Trp Trp Ser Tyr Met Gln Gln Ala Arg Asp
195 200 205Lys Asn Ile Gly Trp Arg Ile Asp Tyr Phe Leu Cys Ser Asn Pro Leu
210 215 220Lys Thr Arg Leu Lys Asp Ala Leu Ile Tyr Lys Asp Ile Leu Gly Ser225 230 235 240Asp His Cys Pro Val Gly Leu Glu Leu Val
245 250
(2) Sequence 347 data:
(i) sequence characteristics:
(A) length: 618bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 62...571
(D) Other information:
(xi) Description of the sequence: sequence 347: AGAATGCGAG CGTTAAAAAA GAAATTTATG TGCCTAATAA GCTTGTTAAT TTTGTTATCG 60C ATG AGG GCT TTA CTT TTT TTT ATT TTG TTA CTT TGG TTC AAG GGT TGT 109 Met Arg Ala Leu Leu Phe Phe Ile Leu Leu Leu Trp Phe Lys Gly Cys 151015 GGG TAT AAG CCT ATT GCA GCT TAC GCT CAA AAC GCT TTA GGC GAT AGC 157Gly Tyr Lys Pro Ile Ala Ala Tyr Ala Gln Asn Ala Leu Gly Asp Ser
20 25 30GTA TAC GTG AAA CTC ATT GTG AAT TTG CCT AAC CCT GAA AAC TCT GTA 205Val Tyr Val Lys Leu Ile Val Asn Leu Pro Asn Pro Glu Asn Ser Val
35 40 45GAG TTT AAG GAT TTG ATG AAT CGT TTA GTC GTG CAA CGC TTC CAA AGC 253Glu Phe Lys Asp Leu Met Asn Arg Leu Val Val Gln Arg Phe Gln Ser
50 55 60CGC TTA GCG AGT GAA AAG GAT GCG GAT TCT ATC ATT ATT ATA GAA ATC 301Arg Leu Ala Ser Glu Lys Asp Ala Asp Ser Ile Ile Ile Ile Glu Ile65 70 75 80ACG AAT GTA ACC GAT ACG AGT ATC ACG CAA AAT AAA GAA GGC TTC ACG 349Thr Asn Val Thr Asp Thr Ser Ile Thr Gln Asn Lys Glu Gly Phe Thr
85 90 95ACT TTC TAT CGC GCA ACC GTG TCT GTG AAT TAC ACC TAC GAT AAT AAA 397Thr Phe Tyr Arg Ala Thr Val Ser Val Asn Tyr Thr Tyr Asp Asn Lys
100 105110AGA GGC ACA CAA AAG ACT TTT CAA GAT AGC GGG TAT TAC AAT TAC GCT 445Arg Gly Thr Gln Lys Thr Phe Gln Asp Ser Gly Tyr Tyr Asn Tyr Ala
115 120 125GTG AAT TTG CAA GAC CCC CTT AAT ACC TAC CAG AAC CGC TAT TAT GCT 493Val Asn Leu Gln Asp Pro Leu Asn Thr Tyr Gln Asn Arg Tyr Tyr Ala
130 135 140ATC AAT CAG GCT GTG GAA CAG ACT TTG ACT AAA TTT GTG GCT CAA ATC 541Ile Asn Gln Ala Val Glu Gln Thr Leu Thr Lys Phe Val Ala Gln Ile145 150 155 160GCT TAT GAG GGG AAA TTC AAT AAT GAA AAA TAGCCCTTTG AATGGATTGA ATG 594Ala Tyr Glu Gly Lys Phe Asn Asn Glu Lys
165 170GACTAAAGGC GTTTTTAGAA ACAA 618
(2) Sequence 348 data:
(i) sequence characteristics:
(A) length: 170 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 348: met Arg Ala Leu Leu Phe Phe Ile Leu Leu Leu Trp Phe Lys Gly Cys 151015 Gly Tyr Lys Pro Ile Ala Ala Tyr Ala Gln Asn Ala Leu Gly Asp Ser
20 25 30Val Tyr Val Lys Leu Ile Val Asn Leu Pro Asn Pro Glu Asn Ser Val
35 40 45Glu Phe Lys Asp Leu Met Asn Arg Leu Val Val Gln Arg Phe Gln Ser
50 55 60Arg Leu Ala Ser Glu Lys Asp Ala Asp Ser Ile Ile Ile Ile Glu Ile65 70 75 80Thr Asn Val Thr Asp Thr Ser Ile Thr Gln Asn Lys Glu Gly Phe Thr
85 90 95Thr Phe Tyr Arg Ala Thr Val Ser Val Asn Tyr Thr Tyr Asp Asn Lys
100 105 110Arg Gly Thr Gln Lys Thr Phe Gln Asp Ser Gly Tyr Tyr Asn Tyr Ala
115 120 125Val Asn Leu Gln Asp Pro Leu Asn Thr Tyr Gln Asn Arg Tyr Tyr Ala
130 135 140Ile Asn Gln Ala Val Glu Gln Thr Leu Thr Lys Phe Val Ala Gln Ile145 150 155 160Ala Tyr Glu Gly Lys Phe Asn Asn Glu Lys
165 170
(2) Sequence 349 material:
(i) sequence characteristics:
(A) length: 1277bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 61...1224
(D) Other information:
(xi) Description of the sequence: sequence 349: AATACCCATA AAATACCTTA AGAGAACGCC TATTCAAAAA CCAAAAATAA GGAAATCCTA 60ATG ACT ACA GAC AGA AAT TTG TTT TTT TGC GCT TCG CTA TTG ATT TTT 108Met Thr Thr Asp Arg Asn Leu Phe Phe Cys Ala Ser Leu Leu Ile Phe 151015 TTG GGG GTA TTG ATG AGC TAT TCG CTC TCA ACT TAC ACC ACA GTG GTG 156Leu Gly Val Leu Met Ser Tyr Ser Leu Ser Thr Tyr Thr Thr Val Val
20 25 30CTG TAT CAT TAT GGG GAG TTC CAT TTT TTC ATA CGC CAG CTT GTG AGC 204Leu Tyr His Tyr Gly Glu Phe His Phe Phe Ile Arg Gln Leu Val Ser
35 40 45GCG ATC ATA GGG ATT GTT ATC ATG TGG GGG TTG TCT AGG GTT GAT CCT 252Ala Ile Ile Gly Ile Val Ile Met Trp Gly Leu Ser Arg Val Asp Pro
50 55 60AGC AAG TGG TTT AGC CGT TTG GGG TTT TTT CTT CTT TTT GTC CCA CCA 300Ser Lys Trp Phe Ser Arg Leu Gly Phe Phe Leu Leu Phe Val Pro Pro65 70 75 80TTA CTC ATT ATT GGC ATG TTT TTT TTG CCA GAA AGC CTT TCT AGC AGT 348Leu Leu Ile Ile Gly Met Phe Phe Leu Pro Glu Ser Leu Ser Ser Ser
85 90 95GCT GGG GGG GCG AAG CGA TGG ATT CGT TTG GGG TTT TTT TCT CTA GCG 396Ala Gly Gly Ala Lys Arg Trp Ile Arg Leu Gly Phe Phe Ser Leu Ala
100 105 110CCT TTG GAG TTT TTG AAG ATT GGT TTC ACC TTT TTT CTT GCG TGG AGT 444Pro Leu Glu Phe Leu Lys Ile Gly Phe Thr Phe Phe Leu Ala Trp Ser
115 120 125TTG TCT CGC ACT TTT GTG GCA AAA GAA AAG GCT AAT GTT AAA GAA GAA 492Leu Ser Arg Thr Phe Val Ala Lys Glu Lys Ala Asn Val Lys Glu Glu
130 135 140CTC ATC ACT TTT GTG CCT TAT TCA GTG GTG TTT GTA GCC TTA GCG ATT 540Leu Ile Thr Phe Val Pro Tyr Ser Val Val Phe Val Ala Leu Ala Ile145 150 155 160GGG GTG GGG GTT TTG CAA AAC GAT TTG GGG CAG ATT GTT CTT TTG GGG 588Gly Val Gly Val Leu Gln Asn Asp Leu Gly Gln Ile Val Leu Leu Gly
165 170175GCG GTT TTA GCG GTG TTG TTG GTT TTT TCT GGG GGG AGC GTG CAT TTG 636Ala Val Leu Ala Val Leu Leu Val Phe Ser Gly Gly Ser Val His Leu
180 185 190TTT GGC TTG ATT ATT TCA GGG GCG TTT GCG ATC AGC GTT TTA GCG ATT 684Phe Gly Leu Ile Ile Ser Gly Ala Phe Ala Ile Ser Val Leu Ala Ile
195 200 205GTT ACA AGC GAG CAT AGG ATT TTG CGC CTG AAA TTG TGG TGG TCT AAT 732Val Thr Ser Glu His Arg Ile Leu Arg Leu Lys Leu Trp Trp Ser Asn
210 215 220TTG CAA AAT TCG CTT TTC ACG CTC TTG CCG GAT AGA TTA GCG AAC GCT 780Leu Gln Asn Ser Leu Phe Thr Leu Leu Pro Asp Arg Leu Ala Asn Ala225 230 235 240CTT AGA ATA AGC GAC TTG CCC GAA TCC TAT CAG GTC TTT CAT GCA GGC 828Leu Arg Ile Ser Asp Leu Pro Glu Ser Tyr Gln Val Phe His Ala Gly
245 250 255AAT GCC ATG CAT AAT GGG GGG TTG TTT GGG CAA GGG CTT GGG CTT GGG 876Asn Ala Met His Asn Gly Gly Leu Phe Gly Gln Gly Leu Gly Leu Gly
260 265 270CAA ATC AAG CTT GGG TTT TTG AGC GAA GTG CAT ACG GAC ATG GTC TTA 924Gln Ile Lys Leu Gly Phe Leu Ser Glu Val His Thr Asp Met Val Leu
275 280 285GCT GGG ATC GCC GAA GAA TGG GGG TTT TTG GGG CTA TGC GTT TGT TTT 972Ala Gly Ile Ala Glu Glu Trp Gly Phe Leu Gly Leu Cys Val Cys Phe
290 295 300ATT TTG TTT TCT GTT TTG ATT GTT TTG ATT TTT AGG ATC GCT AAC CGC 1020Ile Leu Phe Ser Val Leu Ile Val Leu Ile Phe Arg Ile Ala Asn Arg305 310 315 320TTG AAA GAG CCA AAA TAT TCG CTA TTT TGC GTG GGC GTG GTG CTG CTT 1068Leu Lys Glu Pro Lys Tyr Ser Leu Phe Cys Val Gly Val Val Leu Leu
325 330 335ATT AGT TTT TCT TTG GTG ATC AAC GCC TTT GGG GTG GGC GGG ATT CTT 1116Ile Ser Phe Ser Leu Val Ile Asn Ala Phe Gly Val Gly Gly Ile Leu
340 345 350CCG GTT AAA GGT CTA GCG GTG CCG TTT TTG AGC TAT GGA GGG AGT TCG 1164Pro Val Lys Gly Leu Ala Val Pro Phe Leu Ser Tyr Gly Gly Ser Ser
355 360 365CTT CTA GCG AAT TGT ATC GCT ATA GGG CTT GTT CTA AGC CTA GCG CGA 1212Leu Leu Ala Asn Cys Ile Ala Ile Gly Leu Val Leu Ser Leu Ala Arg
370 375 380TAC ACG AAA GGC TAAAAACATC AACCCCTTTT TAAAAATTAA TGCCATAAAA AGGGC 1269Tyr Thr Lys Gly385TCACCTC 1277
(2) Sequence 350 data:
(i) sequence characteristics:
(A) length: 388 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 350: met Thr Thr Asp Arg Asn Leu Phe Phe Cys Ala Ser Leu Leu Ile Phe 151015 Leu Gly Val Leu Met Ser Tyr Ser Leu Ser Thr Tyr Thr Thr Val Val
20 25 30Leu Tyr His Tyr Gly Glu Phe His Phe Phe Ile Arg Gln Leu Val Ser
35 40 45Ala Ile Ile Gly Ile Val Ile Met Trp Gly Leu Ser Arg Val Asp Pro
50 55 60Ser Lys Trp Phe Ser Arg Leu Gly Phe Phe Leu Leu Phe Val Pro Pro65 70 75 80Leu Leu Ile Ile Gly Met Phe Phe Leu Pro Glu Ser Leu Ser Ser Ser
85 90 95Ala Gly Gly Ala Lys Arg Trp Ile Arg Leu Gly Phe Phe Ser Leu Ala
100 105 110Pro Leu Glu Phe Leu Lys Ile Gly Phe Thr Phe Phe Leu Ala Trp Ser
115 120 125Leu Ser Arg Thr Phe Val Ala Lys Glu Lys Ala Asn Val Lys Glu Glu
130 135 140Leu Ile Thr Phe Val Pro Tyr Ser Val Val Phe Val Ala Leu Ala Ile145 150 155 160Gly Val Gly Val Leu Gln Asn Asp Leu Gly Gln Ile Val Leu Leu Gly
165 170 175Ala Val Leu Ala Val Leu Leu Val Phe Ser Gly Gly Ser Val His Leu
180 185 190Phe Gly Leu Ile Ile Ser Gly Ala Phe Ala Ile Ser Val Leu Ala Ile
195 200 205Val Thr Ser Glu His Arg Ile Leu Arg Leu Lys Leu Trp Trp Ser Asn
210 215 220Leu Gln Asn Ser Leu Phe Thr Leu Leu Pro Asp Arg Leu Ala Asn Ala225 230 235 240Leu Arg Ile Ser Asp Leu Pro Glu Ser Tyr Gln Val Phe His Ala Gly
245 250 255Asn Ala Met His Asn Gly Gly Leu Phe Gly Gln Gly Leu Gly Leu Gly
260 265 270Gln Ile Lys Leu Gly Phe Leu Ser Glu Val His Thr Asp Met Val Leu
275 280 285Ala Gly Ile Ala Glu Glu Trp Gly Phe Leu Gly Leu Cys Val Cys Phe
290 295 300Ile Leu Phe Ser Val Leu Ile Val Leu Ile Phe Arg Ile Ala Asn Arg305 310 315 320Leu Lys Glu Pro Lys Tyr Ser Leu Phe Cys Val Gly Val Val Leu Leu
325 330 335Ile Ser Phe Ser Leu Val Ile Asn Ala Phe Gly Val Gly Gly Ile Leu
340 345 350Pro Val Lys Gly Leu Ala Val Pro Phe Leu Ser Tyr Gly Gly Ser Ser
355 360 365Leu Leu Ala Asn Cys Ile Ala Ile Gly Leu Val Leu Ser Leu Ala Arg
370 375 380Tyr Thr Lys Gly385
(2) Data of sequence 351:
(i) sequence characteristics:
(A) length: 961bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...908
(D) Other information:
(xi) Description of the sequence: sequence 351: AGAACAGTAT CTATTTTTGT TGCGGTTGTA TATTTAATTA GGAGTTTGGT GTG AAA 56
Val Lys
1CGG ATT TTA TTT TTT TTA GTA GCT ACG ACT TTT TTG TTG AGA GCA GAA 104Arg Ile Leu Phe Phe Leu Val Ala Thr Thr Phe Leu Leu Arg Ala Glu
5 10 15ACG GAT TCT GCC ACT ATT AAC ACT ACA GTT GAT CCC AAT GTT ATG TTT 152Thr Asp Ser Ala Thr Ile Asn Thr Thr Val Asp Pro Asn Val Met Phe
20 25 30TCT GAA AGC TCC ACA GGG AAT GTG AAA AAA GAC CGC AAG AGG GTT TTA 200Ser Glu Ser Ser Thr Gly Asn Val Lys Lys Asp Arg Lys Arg Val Leu35 40 45 50AAG AGC ATG GTT AAT TTG GAA AAA GAG CGC GTG AAG AAT TTT AAC CGG 248Lys Ser Met Val Asn Leu Glu Lys Glu Arg Val Lys Asn Phe Asn Arg
55 60 65TAT TCT GAA ACC AAG ATG AGT AAG GGC GAC TTA TCC GCT TTT GGA GCT 296Tyr Ser Glu Thr Lys Met Ser Lys Gly Asp Leu Ser Ala Phe Gly Ala
70 75 80TTC TTT AAG GGG AGT TTG GAA AGT TGT GTG GAT CAA AAG ATT TGT TAT 344Phe Phe Lys Gly Ser Leu Glu Ser Cys Val Asp Gln Lys Ile Cys Tyr
85 90 95TAT GAG CAT AAA GAT GGC AAG GTT TCT TTT GTG GTG AAT GAC AGG GAG 392Tyr Glu His Lys Asp Gly Lys Val Ser Phe Val Val Asn Asp Arg Glu
100 105 110AAG TTT TAT AAA CAT GTG CTT AAA GAC TTA GGG ACA GAG CTT TCG CTC 440Lys Phe Tyr Lys His Val Leu Lys Asp Leu Gly Thr Glu Leu Ser Leu115 120 125 130CCT TTG TTT AAC TGG CTT TAC AAA GGC TCG GAT TTT GGG GCT TTG CAT 488Pro Leu Phe Asn Trp Leu Tyr Lys Gly Ser Asp Phe Gly Ala Leu His
135 140 145GAG CAG TTT GGG GAT ATG TAT GAT GGG TAT ATC AAA TAC TTG ATC AGT 536Glu Gln Phe Gly Asp Met Tyr Asp Gly Tyr Ile Lys Tyr Leu Ile Ser
150 155 160ATG GTT AGA ATA AGC CAA AAA GAA AAG GCT AGA AAA GTG GAT GCA ATC 584Met Val Arg Ile Ser Gln Lys Glu Lys Ala Arg Lys Val Asp Ala Ile
165 170 175GTT CTT AAG AAA ATG GAA GAA CAA GCT GAG AAA GAC ACT AAG GCA GCG 632Val Leu Lys Lys Met Glu Glu Gln Ala Glu Lys Asp Thr Lys Ala Ala
180 185 190TTT CAA AAG AGG AGC AGT GGG GAG CTT GAA AGC CAT ACT GAT AGC CCT 680Phe Gln Lys Arg Ser Ser Gly Glu Leu Glu Ser His Thr Asp Ser Pro195 200 205 210GAA TTT ATA AGC TCT TCT AAG AGG ACA CAG AAC GCT TCT AAT TCG GAT 728Glu Phe Ile Ser Ser Ser Lys Arg Thr Gln Asn Ala Ser Asn Ser Asp
215 220 225CTC AAT TCT ATG ACC AAT GCT AAC GCG CTC AAA GAA ACA GCT TCA AAA 776Leu Asn Ser Met Thr Asn Ala Asn Ala Leu Lys Glu Thr Ala Ser Lys
230 235 240GAG CCA GAG GCT TCT TCA AAA AAA GAG AAA AAG TCT AAG AAA AAA CGT 824Glu Pro Glu Ala Ser Ser Lys Lys Glu Lys Lys Ser Lys Lys Lys Arg
245 250 255CGC CTT TCA AAG AAA GAA AAA CAA CAA CAA GCC TTG CAA CAA GAG TTT 872Arg Leu Ser Lys Lys Glu Lys Gln Gln Gln Ala Leu Gln Gln Glu Phe
260 265 270GAA AAA CAA ATT AGC GAC TCT AGT AAG TCT GAA AAA TAGTAATAAT AGTTAA 924Glu Lys Gln Ile Ser Asp Ser Ser Lys Ser Glu Lys275 280 285GCTTACCTTT TTAGGGGGCT TTCAATAAAT CTCTTAA 961
(2) Sequence 352 data:
(i) sequence characteristics:
(A) length: 286 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 352: val Lys Arg Ile Leu Phe Phe Leu Val Ala Thr Thr Phe Leu Leu Arg 151015 Ala Glu Thr Asp Ser Ala Thr Ile Asn Thr Thr Val Asp Pro Asn Val
20 25 30Met Phe Ser Glu Ser Ser Thr Gly Asn Val Lys Lys Asp Arg Lys Arg
35 40 45Val Leu Lys Ser Met Val Asn Leu Glu Lys Glu Arg Val Lys Asn Phe
50 55 60Asn Arg Tyr Ser Glu Thr Lys Met Ser Lys Gly Asp Leu Ser Ala Phe65 70 75 80Gly Ala Phe Phe Lys Gly Ser Leu Glu Ser Cys Val Asp Gln Lys Ile
85 90 95Cys Tyr Tyr Glu His Lys Asp Gly Lys Val Ser Phe Val Val Asn Asp
100 105 110Arg Glu Lys Phe Tyr Lys His Val Leu Lys Asp Leu Gly Thr Glu Leu
115 120 125Ser Leu Pro Leu Phe Asn Trp Leu Tyr Lys Gly Ser Asp Phe Gly Ala
130 135 140Leu His Glu Gln Phe Gly Asp Met Tyr Asp Gly Tyr Ile Lys Tyr Leu145 150 155 160Ile Ser Met Val Arg Ile Ser Gln Lys Glu Lys Ala Arg Lys Val Asp
165 170 175Ala Ile Val Leu Lys Lys Met Glu Glu Gln Ala Glu Lys Asp Thr Lys
180 185 190Ala Ala Phe Gln Lys Arg Ser Ser Gly Glu Leu Glu Ser His Thr Asp
195 200 205Ser Pro Glu Phe Ile Ser Ser Ser Lys Arg Thr Gln Asn Ala Ser Asn
210 215 220Ser Asp Leu Asn Ser Met Thr Asn Ala Asn Ala Leu Lys Glu Thr Ala225 230 235 240Ser Lys Glu Pro Glu Ala Ser Ser Lys Lys Glu Lys Lys Ser Lys Lys
245 250 255Lys Arg Arg Leu Ser Lys Lys Glu Lys Gln Gln Gln Ala Leu Gln Gln
260 265 270Glu Phe Glu Lys Gln Ile Ser Asp Ser Ser Lys Ser Glu Lys
275 280 285
(2) Sequence 353 data:
(i) sequence characteristics:
(A) length: 1555bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1499
(D) Other information:
(xi) Description of the sequence: sequence 353: CTTTTTAGCC TCAAGACTTG GGCTTTAACA TTAAAGAATT ATTTTAAGGA ATG ATC 56
Met Ile
1ATG GAA AAA TAC CAT AGC GAC CAA GAA TAC GAA GAA ATC ATC ACC GAC 104Met Glu Lys Tyr His Ser Asp Gln Glu Tyr Glu Glu Ile Ile Thr Asp
5 10 15CAA TTA GGC GAT ATG CAA TTA AGG GAA AAT TTG CGT TCT GCA ATG GAT 152Gln Leu Gly Asp Met Gln Leu Arg Glu Asn Leu Arg Ser Ala Met Asp
20 25 30ACC TTA AGG GCT AAT CGT AAG AAT CTC CTT AAA AAT CGT TAC AGC GAA 200Thr Leu Arg Ala Asn Arg Lys Asn Leu Leu Lys Asn Arg Tyr Ser Glu35 40 45 50TGG GAA AAT TTA AGG GAA TTA GGC AAA GAA GTC AAG CTT AAA ATC TTA 248Trp Glu Asn Leu Arg Glu Leu Gly Lys Glu Val Lys Leu Lys Ile Leu
55 60 65TCC AGG CTT GAT GAA TAT TTG GAA TTG TTT GAA AAA AAC GCC ACT CAA 296Ser Arg Leu Asp Glu Tyr Leu Glu Leu Phe Glu Lys Asn Ala Thr Gln
70 75 80AAC GGC TTT AAA ATC CAT TAC GCT AAA GAC GGC GAT GAA GCT AAT GAA 344Asn Gly Phe Lys Ile His Tyr Ala Lys Asp Gly Asp Glu Ala Asn Glu
85 90 95ATC ATT TAC AAC CTC GCT AAA GAA AAG AAT ATC AAG CGC ATT TTA AAG 392Ile Ile Tyr Asn Leu Ala Lys Glu Lys Asn Ile Lys Arg He Leu Lys
100 105 110CAA AAA TCC ATG GCG AGC GAA GAA ATT GGC TTG AAC CAT TAC TTG AAA 440Gln Lys Ser Met Ala Ser Glu Glu Ile Gly Leu Asn His Tyr Leu Lys115 120 125 130GAA AAG GGC ATT CAA GCA CAA GAA ACG GAT TTG GGC GAA TTG ATT ATC 488Glu Lys Gly Ile Gln Ala Gln Glu Thr Asp Leu Gly Glu Leu Ile Ile
135 140 145CAA CTC ATC AAT GAA CAC CCT GTG CAT ATT GTC GTG CCA GCT ATC CAT 536Gln Leu Ile Asn Glu His Pro Val His Ile Val Val Pro Ala Ile His
150 155 160AAA AAC CGC AAG CAA ATC GGT AAG ATT TTT GAA GAA AAA CTC AAC GCC 584Lys Asn Arg Lys Gln Ile Gly Lys Ile Phe Glu Glu Lys Leu Asn Ala
165 170 175GCT TAT GAA GAA GAG CCT GAA AAG CTT AAT GCG ATC GCC AGA AAA CAC 632Ala Tyr Glu Glu Glu Pro Glu Lys Leu Asn Ala Ile Ala Arg Lys His
180 185 190ATG CGC AAA GAA TTT GAA AGC TTT AAA ATG GGG ATT AGT GGG GTT AAT 680Met Arg Lys Glu Phe Glu Ser Phe Lys Met Gly Ile Ser Gly Val Asn195 200 205 210TTT GCT ATC GCT AAC GAA GGA GCG ATC TGG TTA GTG GAA AAT GAA GGC 728Phe Ala Ile Ala Asn Glu Gly Ala Ile Trp Leu Val Glu Asn Glu Gly
215 220 225AAT GGC AGA ATG AGC ACC ACT GCA TGC GAT GTG CAT GTC GCA ATT TGT 776Asn Gly Arg Met Ser Thr Thr Ala Cys Asp Val His Val Ala Ile Cys
230 235 240GGG ATT GAA AAA TTA GTA GAA AGC TTT GAT GAT GCG GCG ATT TTA AAC 824Gly Ile Glu Lys Leu Val Glu Ser Phe Asp Asp Ala Ala Ile Leu Asn
245 250 255AAT TTG CTC GCC CCA AGC GCT GTG GGT GTG CCT ATC ACT TGC TAT CAA 872Asn Leu Leu Ala Pro Ser Ala Val Gly Val Pro Ile Thr Cys Tyr Gln
260 265 270AAC ATT ATC ACA GGC CCT AGA AAA GAG GGC GAT TTA GAC GGC CCT AAA 920Asn Ile Ile Thr Gly Pro Arg Lys Glu Gly Asp Leu Asp Gly Pro Lys275 280 285 290GAA GCC CAC ATC ATT TTA TTA GAC AAC AAC CGC TCT AAT ATT TTG GCT 968Glu Ala His Ile Ile Leu Leu Asp Asn Asn Arg Ser Asn Ile Leu Ala
295 300 305GAT GAA AAG TAT TAT CGC GCT CTT TCA TGC ATC CGT TGC GGG ACT TGT 1016Asp Glu Lys Tyr Tyr Arg Ala Leu Ser Cys Ile Arg Cys Gly Thr Cys
310 315 320TTG AAC CAC TGC CCT GTG TAT GAT AAA ATC GGT GGG CAT GCC TAT CTT 1064Leu Asn His Cys Pro Val Tyr Asp Lys Ile Gly Gly His Ala Tyr Leu
325 330 335TCT ACT TAT CCT GGC CCT ATA GGC GTG GTG GTA TCC CCC CAA CTC TTT 1112Ser Thr Tyr Pro Gly Pro Ile Gly Val Val Val Ser Pro Gln Leu Phe
340 345 350GGC TTG AAT AAT TAC GGG CAT ATC CCT AAT TTG TGC AGT CTT TGC GGG 1160Gly Leu Asn Asn Tyr Gly His Ile Pro Asn Leu Cys Ser Leu Cys Gly355 360 365 370CGT TGC ACT GAA GTA TGC CCC GTA GAA ATC CCT TTA GCC GAA CTC ATT 1208Arg Cys Thr Glu Val Cys Pro Val Glu Ile Pro Leu Ala Glu Leu Ile
375 380 385AGG GAT TTA CGA TCC GAT AAA GTG GGC GAG GGC AGG GGT GTA ATT AAG 1256Arg Asp Leu Arg Ser Asp Lys Val Gly Glu Gly Arg Gly Val Ile Lys
390 395 400GGG GCT AAA AGC ACC CAA CAC AGC GGG ATG GAA AAA TTC TCT ATG AAA 1304Gly Ala Lys Ser Thr Gln His Ser Gly Met Glu Lys Phe Ser Met Lys
405 410 415ATG TTT GCC AAA ATG GCA AGC GAT GGG GCT AAG TGG CGT TTC CAA TTG 1352Met Phe Ala Lys Met Ala Ser Asp Gly Ala Lys Trp Arg Phe Gln Leu
420 425 430AAA ATG GCT CAA TTT TTC TCG CCT TTA GGC AAG CTT TTA GCT CCC ATA 1400Lys Met Ala Gln Phe Phe Ser Pro Leu Gly Lys Leu Leu Ala Pro Ile435 440 445 450CTG CCT TTA GTC AAA GAG TGG GCG AGC GTT AGG ACC TTA CCC AAT ATG 1448Leu Pro Leu Val Lys Glu Trp Ala Ser Val Arg Thr Leu Pro Asn Met
455 460 465GAC ACG AGC TTG CAT GCA AAA GTC CAG CAC TTA GAA GGG GTG ATT TAT 1496Asp Thr Ser Leu His Ala Lys Val Gln His Leu Glu Gly Val Ile Tyr
470 475 480GAG TAAAGAGCTT ATTTTAAAGC GCATTAAAGA AGCCAGAGCC AAGCATGCCA TTCAGG 1555Glu
(2) Sequence 354 data:
(i) sequence characteristics:
(A) length: 483 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 354: met Ile Met Glu Lys Tyr His Ser Asp Gln Glu Tyr Glu Glu Ile Ile 151015 Thr Asp Gln Leu Gly Asp Met Gln Leu Arg Glu Asn Leu Arg Ser Ala
20 25 30Met Asp Thr Leu Arg Ala Asn Arg Lys Asn Leu Leu Lys Asn Arg Tyr
35 40 45Ser Glu Trp Glu Asn Leu Arg Glu Leu Gly Lys Glu Val Lys Leu Lys
50 55 60Ile Leu Ser Arg Leu Asp Glu Tyr Leu Glu Leu Phe Glu Lys Asn Ala65 70 75 80Thr Gln Asn Gly Phe Lys Ile His Tyr Ala Lys Asp Gly Asp Glu Ala
85 90 95Asn Glu Ile Ile Tyr Asn Leu Ala Lys Glu Lys Asn Ile Lys Arg Ile
100 105 110Leu Lys Gln Lys Ser Met Ala Ser Glu Glu Ile Gly Leu Asn His Tyr
115 120 125Leu Lys Glu Lys Gly Ile Gln Ala Gln Glu Thr Asp Leu Gly Glu Leu
130 135 140Ile IleGln Leu Ile Asn Glu His Pro Val His Ile Val Val Pro Ala145 150 155 160Ile His Lys Asn Arg Lys Gln Ile Gly Lys Ile Phe Glu Glu Lys Leu
165 170 175Asn Ala Ala Tyr Glu Glu Glu Pro Glu Lys Leu Asn Ala Ile Ala Arg
180 185 190Lys His Met Arg Lys Glu Phe Glu Ser Phe Lys Met Gly Ile Ser Gly
195 200 205Val Asn Phe Ala Ile Ala Asn Glu Gly Ala Ile Trp Leu Val Glu Asn
210 215 220Glu Gly Asn Gly Arg Met Ser Thr Thr Ala Cys Asp Val His Val Ala225 230 235 240Ile Cys Gly Ile Glu Lys Leu Val Glu Ser Phe Asp Asp Ala Ala Ile
245 250 255Leu Asn Asn Leu Leu Ala Pro Ser Ala Val Gly Val Pro Ile Thr Cys
260 265 270Tyr Gln Asn Ile Ile Thr Gly Pro Arg Lys Glu Gly Asp Leu Asp Gly
275 280 285Pro Lys Glu Ala His Ile Ile Leu Leu Asp Asn Asn Arg Ser Asn Ile
290 295 300Leu Ala Asp Glu Lys Tyr Tyr Arg Ala Leu Ser Cys Ile Arg Cys Gly305 310 315 320Thr Cys Leu Asn His Cys Pro Val Tyr Asp Lys Ile Gly Gly His Ala
325 330 335Tyr Leu Ser Thr Tyr Pro Gly Pro Ile Gly Val Val Val Ser Pro Gln
340 345 350Leu Phe Gly Leu Asn Asn Tyr Gly His Ile Pro Asn Leu Cys Ser Leu
355 360 365Cys Gly Arg Cys Thr Glu Val Cys Pro Val Glu Ile Pro Leu Ala Glu
370 375 380Leu Ile Arg Asp Leu Arg Ser Asp Lys Val Gly Glu Gly Arg Gly Val385 390 395 400Ile Lys Gly Ala Lys Ser Thr Gln His Ser Gly Met Glu Lys Phe Ser
405 410 415Met Lys Met Phe Ala Lys Met Ala Ser Asp Gly Ala Lys Trp Arg Phe
420 425 430Gln Leu Lys Met Ala Gln Phe Phe Ser Pro Leu Gly Lys Leu Leu Ala
435 440 445Pro Ile Leu Pro Leu Val Lys Glu Trp Ala Ser Val Arg Thr Leu Pro
450 455 460Asn Met Asp Thr Ser Leu His Ala Lys Val Gln His Leu Glu Gly Val465 470 475 480Ile Tyr Glu
(2) Sequence 355 data:
(i) sequence characteristics:
(A) length: 1630bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 294...1577
(D) Other information:
(xi) Description of the sequence: sequence 355: GTATCGCCAC TTTGCGTAAC AGGATGTTGA AAGTGGGTAA AAGCCGCTAA TTTCTTTTTA 60GTGGGTCGTT TTTGAAAATC TTTTTAGTCT TTTTAAGCGT CTTTTTTTTT AATGGGTGTT 120TTGGGTTAGT CTATAAGACT CCCATTTCAA GCTCTCCTAT CTCTTATGAT CCCTACACTA 180CCCCCATTGG GAGCTTGTAT GCTGAAAAAT TAAAAGAAAA CCCTAACCATAGCGCGGCCA 240TTCTTTTAGA AGATGGCTTT GACGCTCTGT TGCATAGAGT GGGACTTATT AGA ATG 296
Met
1AGC CAA AAA AGC ATT GAC ATG CAA ACT TAT ATC TAT AAA AAC GAC CTT 344Ser Gln Lys Ser Ile Asp Met Gln Thr Tyr Ile Tyr Lys Asn Asp Leu
5 10 15TCT TCT CAA GTG ATT GCT AAA GAA CTT TTA AAT GCG GCC AAT CGT GGG 392Ser Ser Gln Val Ile Ala Lys Glu Leu Leu Asn Ala Ala Asn Arg Gly
20 25 30GTA AAA GTG CGC ATC CTT TTA GAC GAT AAC GGA TTG GAT TCG GAT TTT 440Val Lys Val Arg Ile Leu Leu Asp Asp Asn Gly Leu Asp Ser Asp Phe
35 40 45TCA GAT ATT ATG CTC TTA AAT TTC CAT AAA AAC ATT GAG GTG AAA ATT 488Ser Asp Ile Met Leu Leu Asn Phe His Lys Asn Ile Glu Val Lys Ile50 55 60 65TTT AAC CCC TAC TAT ATC CGC AAT AAA GGC TTG CGT TAT TTT GAA ATG 536Phe Asn Pro Tyr Tyr Ile Arg Asn Lys Gly Leu Arg Tyr Phe Glu Met
70 75 80CTT GCG GAT TAT GAG CGC ATT AAA AAA CGC ATG CAC AAC AAG CTT TTC 584Leu Ala Asp Tyr Glu Arg Ile Lys Lys Arg Met His Asn Lys Leu Phe
85 90 95ATC GTG GAT AAT TTC GCT GTC ATT ATA GGG GGG CGC AAT ATT GGG GAC 632Ile Val Asp Asn Phe Ala Val Ile Ile Gly Gly Arg Asn Ile Gly Asp
100 105 110AAT TAT TTT GAT AAC GAT TTA GAC ACG AAT TTT TTA GAT TTA GAC GCT 680Asn Tyr Phe Asp Asn Asp Leu Asp Thr Asn Phe Leu Asp Leu Asp Ala
115 120 125TTG TTT TTT GGG GGG GTT GCT TCA AAA GCC AAA GAA AGC TTT GAA CGC 728Leu Phe Phe Gly Gly Val Ala Ser Lys Ala Lys Glu Ser Phe Glu Arg130 135 140 145TAT TGG AGA TTC CAC CGC TCT ATC CCT GTT TCA TTA CTA AGA ACC CAT 776Tyr Trp Arg Phe His Arg Ser Ile Pro Val Ser Leu Leu Arg Thr His
150 155 160AAA AGA CTC AAA AAC AAC GCT AAA GAA ATC GCT AAA CTC CAT GAA AAA 824Lys Arg Leu Lys Asn Asn Ala Lys Glu Ile Ala Lys Leu His Glu Lys
165 170 175ATC CCT ATC AGC GCT GAA GAC AAA AAC CAG TTT GAA AAA AAA GTC AAT 872Ile Pro Ile Ser Ala Glu Asp Lys Asn Gln Phe Glu Lys Lys Val Asn
180 185 190GAT TTT ATA GAT CGT TTC CAA AAA TAC CAA TAC CCC ATT TAT TAT GGG 920Asp Phe Ile Asp Arg Phe Gln Lys Tyr Gln Tyr Pro Ile Tyr Tyr Gly
195 200 205AAT GCC ATT TTT TTA GCC GAT TCA CCC AAA AAA ATT GAC ACG CCC TTG 968Asn Ala Ile Phe Leu Ala Asp Ser Pro Lys Lys Ile Asp Thr Pro Leu210 215 220 225TAT TCG CCT ATC AAA ATC GCT TTT GAG AAA GCC CTT AAA AAC GCT AAG 1016Tyr Ser Pro Ile Lys Ile Ala Phe Glu Lys Ala Leu Lys Asn Ala Lys
230 235 240GAC TCC GTT TTT ATC GCT TCA TCG TAT TTT ATT CCA GGC AAA AAG ATG 1064Asp Ser Val Phe Ile Ala Ser Ser Tyr Phe Ile Pro Gly Lys Lys Met
245 250 255ATG AAA ATC TTT AAA AAT CAA ATT TCT AAG GGG ATT GAA TTG AAC ATC 1112Met Lys Ile Phe Lys Asn Gln Ile Ser Lys Gly Ile Glu Leu Asn Ile
260 265 270CTT ACC AAT TCC CTT TCA TCT ACT GAT GCG ATA GTG GTC TAT GGG GCA 1160Leu Thr Asn Ser Leu Ser Ser Thr Asp Ala Ile Val Val Tyr Gly Ala
275 280 285TGG GAA AGG TAT CGC AAC CAA TTA GTG CGA ATG GGC GCG AAT GTC TAT 1208Trp Glu Arg Tyr Arg Asn Gln Leu Val Arg Met Gly Ala Asn Val Tyr290 295 300 305GAA ATA CGA AAC GAT TTT TTC AAC CGC CAG ATT AAA GGG CGC TTT AGC 1256Glu Ile Arg Asn Asp Phe Phe Asn Arg Gln Ile Lys Gly Arg Phe Ser
310 315 320ACC AAA CAT TCC TTG CAT GGC AAG ACG ATT GTT TTT GAT GAC AAT TTA 1304Thr Lys His Ser Leu His Gly Lys Thr Ile Val Phe Asp Asp Asn Leu
325 330 335ACG CTT CTA GGG AGT TTC AAT ATT GAT CCG CGC TCT GCA TAC ATC AAC 1352Thr Leu Leu Gly Ser Phe Asn Ile Asp Pro Arg Ser Ala Tyr Ile Asn
340 345 350ACT GAA AGC GCG GTT TTG TTT GAC AAC CCG TCT TTT GCT AAA AGG GTG 1400Thr Glu Ser Ala Val Leu Phe Asp Asn Pro Ser Phe Ala Lys Arg Val
355 360 365CGT TTG TCG CTT AAA GAT CAT GCC CAA CAA TCA TGG CAT TTG GTG GTG 1448Arg Leu Ser Leu Lys Asp His Ala Gln Gln Ser Trp His Leu Val Val370 375 380 385TAT CGG CAT AGA GTG ATT TGG GAA GCG GTG GAA GAA GGC ATT TTA ATC 1496Tyr Arg His Arg Val Ile Trp Glu Ala Val Glu Glu Gly Ile Leu Ile
390 395 400CAT GAA AAA ACT TCG CCT GAC ACT TCC TTC TTT TTG CGC TTG ATT AAA 1544His Glu Lys Thr Ser Pro Asp Thr Ser Phe Phe Leu Arg Leu Ile Lys
405 410 415GAA TGG TCT AAA GTC CTT CCT GAA AGA GAG CTT TAAAACTTTT AATGCGCTTT 1597Glu Trp Ser Lys Val Leu Pro Glu Arg Glu Leu
420 425ATTTTGCGAA AAAGCGATGT TATTGGTAAC GGC1630
(2) Sequence 356 data:
(i) sequence characteristics:
(A) length: 428 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 356: met Ser Gln Lys Ser Ile Asp Met Gln Thr Tyr Ile Tyr Lys Asn Asp 151015 Leu Ser Ser Gln Val Ile Ala Lys Glu Leu Leu Asn Ala Ala Asn Arg
20 25 30Gly Val Lys Val Arg Ile Leu Leu Asp Asp Asn Gly Leu Asp Ser Asp
35 40 45Phe Ser Asp Ile Met Leu Leu Asn Phe His Lys Asn Ile Glu Val Lys
50 55 60Ile Phe Asn Pro Tyr Tyr Ile Arg Asn Lys Gly Leu Arg Tyr Phe Glu65 70 75 80Met Leu Ala Asp Tyr Glu Arg Ile Lys Lys Arg Met His Asn Lys Leu
85 90 95Phe Ile Val Asp Asn Phe Ala Val Ile Ile Gly Gly Arg Asn Ile Gly
100 105 110Asp Asn Tyr Phe Asp Asn Asp Leu Asp Thr Asn Phe Leu Asp Leu Asp
115 120 125Ala Leu Phe Phe Gly Gly Val Ala Ser Lys Ala Lys Glu Ser Phe Glu
130 135 140Arg Tyr Trp Arg Phe His Arg Ser Ile Pro Val Ser Leu Leu Arg Thr145 150 155 160His Lys Arg Leu Lys Asn Asn Ala Lys Glu Ile Ala Lys Leu His Glu
165 170 175Lys Ile Pro Ile Ser Ala Glu Asp Lys Asn Gln Phe Glu Lys Lys Val
180 185 190Asn Asp Phe Ile Asp Arg Phe Gln Lys Tyr Gln Tyr Pro Ile Tyr Tyr
195 200 205Gly Asn Ala Ile Phe Leu Ala Asp Ser Pro Lys Lys Ile Asp Thr Pro
210 215 220Leu Tyr Ser Pro Ile Lys Ile Ala Phe Glu Lys Ala Leu Lys Asn Ala225 230 235 240Lys Asp Ser Val Phe Ile Ala Ser Ser Tyr Phe Ile Pro Gly Lys Lys
245 250 255Met Met Lys Ile Phe Lys Asn Gln Ile Ser Lys Gly Ile Glu Leu Asn
260 265 270Ile Leu Thr Asn Ser Leu Ser Ser Thr Asp Ala Ile Val Val Tyr Gly
275 280 285Ala Trp Glu Arg Tyr Arg Asn Gln Leu Val Arg Met Gly Ala Asn Val
290 295 300Tyr Glu Ile Arg Asn Asp Phe Phe Asn Arg Gln Ile Lys Gly Arg Phe305 310 315 320Ser Thr Lys His Ser Leu His Gly Lys Thr Ile Val Phe Asp Asp Asn
325 330 335Leu Thr Leu Leu Gly Ser Phe Asn Ile Asp Pro Arg Ser Ala Tyr Ile
340 345 350Asn Thr Glu Ser Ala Val Leu Phe Asp Asn Pro Ser Phe Ala Lys Arg
355 360 365Val Arg Leu Ser Leu Lys Asp His Ala Gln Gln Ser Trp His Leu Val
370 375 380Val Tyr Arg His Arg Val Ile Trp Glu ala Val Glu Glu Gly Ile Leu385 390 395 400Ile His Glu Lys Thr Ser Pro Asp Thr Ser Phe Phe Leu Arg Leu Ile
405 410 415Lys Glu Trp Ser Lys Val Leu Pro Glu Arg Glu Leu
420 425
(2) Sequence 357 data:
(i) sequence characteristics:
(A) length: 550bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 79...510
(D) Other information:
(xi) Description of the sequence: sequence 357: AACTCTTTTG GTGTAGGATA GCGATCAAGG TTTTTATGAA AATAAAAGCC TAAAACAATT 60TTAAAAAAAG GACTTTTG ATG AAA ACA TTT GAA ATT CTA AAA CAT TTG CAA 111
Met Lys Thr Phe Glu Ile Leu Lys His Leu Gln
1 5 10GCG GAT GCG ATC GTG TTA TTT ATG AAA GTG CAT AAC TTC CAT TGG AAT 159Ala Asp Ala Ile Val Leu Phe Met Lys Val His Asn Phe His Trp Asn
15 20 25GTG AAA GGC ACC GAT TTT TTC AAT GTG CAT AAA GCC ACT GAA GAA ATT 207Val Lys Gly Thr Asp Phe Phe Asn Val His Lys Ala Thr Glu Glu Ile
30 35 40TAT GAA GAG TTT GCG GAC ATG TTT GAC GAT CTC GCT GAA AGG ATC GTT 255Tyr Glu Glu Phe Ala Asp Met Phe Asp Asp Leu Ala Glu Arg Ile Val
45 50 55CAA TTA GGG CAT CAC CCC TTA GTC ACT TTA TCC GAA GCG ATC AAA CTC 303Gln Leu Gly His His Pro Leu Val Thr Leu Ser Glu Ala Ile Lys Leu60 65 70 75ACT CGT GTT AAA GAA GAA ACT AAA ACG AGC TTC CAC TCT AAA GAC ATC 351Thr Arg Val Lys Glu Glu Thr Lys Thr Ser Phe His Ser Lys Asp Ile
80 85 90TTT AAA GAA ATT CTA GAG GAC TAC AAA TAT CTA GAA AAA GAA TTT AAA 399Phe Lys Glu Ile Leu Glu Asp Tyr Lys Tyr Leu Glu Lys Glu Phe Lys
95 100 105GAG CTC TCT AAC ACC GCT GAA AAA GAA GGC GAT AAA GTT ACC GTA ACT 447Glu Leu Ser Asn Thr Ala Glu Lys Glu Gly Asp Lys Val Thr Val Thr
110 115 120TAT GCG GAT GAT CAA TTA GCC AAG TTG CAA AAA TCC ATT TGG ATG CTG 495Tyr Ala Asp Asp Gln Leu Ala Lys Leu Gln Lys Ser Ile Trp Met Leu
125 130 135CAA GCC CAT TTG GCT TAAGCGACCA AAAAGAAGCC AGCATGAGAG ATTACAGCGA 550Gln Ala His Leu Ala140
(2) Sequence 358 data:
(i) sequence characteristics:
(A) length: 144 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 358: met Lys Thr Phe Glu Ile Leu Lys His Leu Gln Ala Asp Ala Ile Val 151015 Leu Phe Met Lys Val His Asn Phe His Trp Asn Val Lys Gly Thr Asp
20 2530Phe Phe Asn Val His Lys Ala Thr Glu Glu Ile Tyr Glu Glu Phe Ala
35 40 45Asp Met Phe Asp Asp Leu Ala Glu Arg Ile Val Gln Leu Gly His His
50 55 60Pro Leu Val Thr Leu Ser Glu Ala Ile Lys Leu Thr Arg Val Lys Glu65 70 75 80Glu Thr Lys Thr Ser Phe His Ser Lys Asp Ile Phe Lys Glu Ile Leu
85 90 95Glu Asp Tyr Lys Tyr Leu Glu Lys Glu Phe Lys Glu Leu Ser Asn Thr
100 105 110Ala Glu Lys Glu Gly Asp Lys Val Thr Val Thr Tyr Ala Asp Asp Gln
115 120 125Leu Ala Lys Leu Gln Lys Ser Ile Trp Met Leu Gln Ala His Leu Ala
130 135 140
(2) Data on sequence 359:
(i) sequence characteristics:
(A) length: 376bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 323 l
(D) Other information:
(xi) Description of the sequence: sequence 359: CTTTTTTCTC TTCCACTTTT TCCACTTTTT TAAGAGCCTT GTGTTTATGA TTG GGC 56
Leu Gly
1TTT TTG GGT TCA GGT TTG GGT TTT GGT TTA GGC TCA GGC TTA GGC TTT 104Phe Leu Gly Ser Gly Leu Gly Phe Gly Leu Gly Ser Gly Leu Gly Phe
5 10 15TCT ATA GGT TTT GGC GGG GTT GGC GGG GTT GGC GGA GTT GGG GGT GTG 152Ser Ile Gly Phe Gly Gly Val Gly Gly Val Gly Gly Val Gly Gly Val
20 25 30GGA GGC GTT GGA GGT TTT TGG GGG CCA GCC AGC GTG GGT TTA GGA GCG 200Gly Gly Val Gly Gly Phe Trp Gly Pro Ala Ser Val Gly Leu Gly Ala35 40 45 50CCC TGG GTG TTT TTA CTG GGA TCT TGC GAA TGG CCT CTT TTT AAA ACC 248Pro Trp Val Phe Leu Leu Gly Ser Cys Glu Trp Pro Leu Phe Lys Thr
55 60 65AAT AAA TTT TCA GGA TTT AAT TTA ACA AGC TTG GGT TTT GAA GGA AAA 296Asn Lys Phe Ser Gly Phe Asn Leu Thr Ser Leu Gly Phe Glu Gly Lys
70 75 80AAA TCT TCT CTG TGT TCA AAT AAA AAA TAAATCAACC AGTGTAACAA TACAGAC 350Lys Ser Ser Leu Cys Ser Asn Lys Lys
85 90AGAATGAGAG AAAAGAAAAA ATTCCT 376
(2) Sequence 360 data:
(i) sequence characteristics:
(A) length: 91 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 360: leu Gly Phe Leu Gly Ser Gly Leu Gly Phe Gly Leu Gly Ser Gly Leu 151015 Gly Phe Ser Ile Gly Phe Gly Gly Val Gly Gly Val Gly Gly Val Gly
20 25 30Gly Val Gly Gly Val Gly Gly Phe Trp Gly Pro Ala Ser Val Gly Leu
35 40 45Gly Ala Pro Trp Val Phe Leu Leu Gly Ser Cys Glu Trp Pro Leu Phe
50 55 60Lys Thr Asn Lys Phe Ser Gly Phe Asn Leu Thr Ser Leu Gly Phe Glu65 70 75 80Gly Lys Lys Ser Ser Leu Cys Ser Asn Lys Lys
85 90
(2) Sequence 361 data:
(i) sequence characteristics:
(A) length: 2890bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 458...2836
(D) Other information:
(xi) Description of the sequence: sequence 361: TCAAAATTTA AGTTAATTTT AATAATTATT TTTATAGTAT GCATCGGTTT GAATTAAATG 60AGAAAGGTTA TCACAATGAA TGGTTATTTG AGAGTAAAAA CCTCTTATTT TTTAGCGTTG 120AACGCTTTGA CTTTTTTGTC TTTTAACTCT TTGGTGGGCG CGAAAGAACA GCATCACACT 180TTGCAAAAAG TGACAACCAC TGAGCAAAAA TTCAATCCAA GCGCGCCGCT TTCATGGCAA 240AGCGAAGAGA TGCGTAATTC CACAAGCTCT CGCACGGTGA TTTCCAACAA GGAACTCAAA 300AAAACGGGGA ATTTGAATAT TGAAAACGCC TTGCAAAACG TGCCAGGGAT TCAAATCAGA 360GACGCTACAG GCACAGGCGT GCTGCCTAAA ATTTCGGTGC TCAAAATTTA AGTTAATTTT 420AATAATTATT TTTATAGTAT GCATCGGTTT GAATTAA ATG AGA AAG GTT ATC ACA 475
Met Arg Lys Val Ile Thr
1 5ATG AAT GGT TAT TTG AGA GTA AAA ACC TCT TAT TTT TTA GCG TTG AAC 523Met Asn Gly Tyr Leu Arg Val Lys Thr Ser Tyr Phe Leu Ala Leu Asn
10 15 20GCT TTG ACT TTT TTG TCT TTT AAC TCT TTG GTG GGC GCG AAA GAA CAG 571Ala Leu Thr Phe Leu Ser Phe Asn Ser Leu Val Gly Ala Lys Glu Gln
25 30 35CAT CAC ACT TTG CAA AAA GTG ACA ACC ACT GAG CAA AAA TTC AAT CCA 619His His Thr Leu Gln Lys Val Thr Thr Thr Glu Gln Lys Phe Asn Pro
40 45 50AGC GCG CCG CTT TCA TGG CAA AGC GAA GAG ATG CGT AAT TCC ACA AGC 667Ser Ala Pro Leu Ser Trp Gln Ser Glu Glu Met Arg Asn Ser Thr Ser55 60 65 70TCT CGC ACG GTG ATT TCC AAC AAG GAA CTC AAA AAA ACG GGG AAT TTG 715Ser Arg Thr Val Ile Ser Asn Lys Glu Leu Lys Lys Thr Gly Asn Leu
75 80 85AAT ATT GAA AAC GCC TTG CAA AAC GTG CCA GGG ATT CAA ATC AGA GAC 763Asn Ile Glu Asn Ala Leu Gln Asn Val Pro Gly Ile Gln Ile Arg Asp
90 95 100GCT ACA GGC ACA GGC GTG CTG CCT AAA ATT TCG GTG CGC GGT TTT GGT 811Ala Thr Gly Thr Gly Val Leu Pro Lys Ile Ser Val Arg Gly Phe Gly
105 110 115GGG GGC GGT AAC GGG CAT AGC AAT ACC AAC ATG ATT TTA GTC AAT GGT 859Gly Gly Gly Asn Gly His Ser Asn Thr Asn Met Ile Leu Val Asn Gly
120 125 130ATC CCC ATT TAT GGC GCG CCG TAT TCC AAT ATT GAA CTG GCG ATT TTC 907Ile Pro Ile Tyr Gly Ala Pro Tyr Ser Asn Ile Glu Leu Ala Ile Phe135 140145 150CCT GTA ACT TTC CAG TCA GTG GAT AGG ATT GAT GTG ATT AAA GGG GGC 955Pro Val Thr Phe Gln Ser Val Asp Arg Ile Asp Val Ile Lys Gly Gly
155 160 165ACG AGC GTG CAA TAC GGC CCT AAT ACT TTT GGA GGC GTG GTG AAT ATC 1003Thr Ser Val Gln Tyr Gly Pro Asn Thr Phe Gly Gly Val Val Asn Ile
170 175 180ATC ACT AAA GAA ATC CCT AAA GAG TGG GAA AAT CAA GCG GCT GAA AGG 1051Ile Thr Lys Glu Ile Pro Lys Glu Trp Glu Asn Gln Ala Ala Glu Arg
185 190 195ATC ACT TTT TGG GGG CGA TCC TCT AAT GGG AAT TTT GTA GAT CCC AAA 1099Ile Thr Phe Trp Gly Arg Ser Ser Asn Gly Asn Phe Val Asp Pro Lys
200 205 210GAA AAA GGC AAG CCT TTA GCC CAA ACT TTA GGA AAC CAA ATG CTG TTT 1147Glu Lys Gly Lys Pro Leu Ala Gln Thr Leu Gly Asn Gln Met Leu Phe215 220 225 230AAC ACT TAC GGG CGA ACG GCT GGA ATG TTG GGT AAG CAT GTA GGA ATT 1195Asn Thr Tyr Gly Arg Thr Ala Gly Met Leu Gly Lys His Val Gly Ile
235 240 245AGC GCT CAA GGC AAT TGG ATT AAC GGG CAA GGT TTC AGG CAA AAC AGC 1243Ser Ala Gln Gly Asn Trp Ile Asn Gly Gln Gly Phe Arg Gln Asn Ser
250 255 260CCC ACA AAG GTG CAA AAC TAC TTG CTT GAT GCG GTT TAT AAG ATT AAT 1291Pro Thr Lys Val Gln Asn Tyr Leu Leu Asp Ala Val Tyr Lys Ile Asn
265 270 275GCG ACC AAT ACT TTT AAA GCT TAT TAC CAA TAT TAT CAA TAC AAC TCT 1339Ala Thr Asn Thr Phe Lys Ala Tyr Tyr Gln Tyr Tyr Gln Tyr Asn Ser
280 285 290TAC CAT CCA GGC ACT TTG AGT GCA CAA GAT TAT GCT TAT AAC CGC TTC 1387Tyr His Pro Gly Thr Leu Ser Ala Gln Asp Tyr Ala Tyr Asn Arg Phe295 300 305 310ATT AAT GAG CGC CCT GAC AAT CAA GAT GGA GGG CGA GCC AAG CGC TTT 1435Ile Asn Glu Arg Pro Asp Asn Gln Asp Gly Gly Arg Ala Lys Arg Phe
315 320 325GGG ATC GTG TAT CAA AAT TAT TTT GGC GAT CCG GAT AGG AAA GTG GGG 1483Gly Ile Val Tyr Gln Asn Tyr Phe Gly Asp Pro Asp Arg Lys Val Gly
330 335 340GGA GAT TTT AAA TTC ACT TAT TTC ACG CAT GAC ATG AGT AGG GAT TTT 1531Gly Asp Phe Lys Phe Thr Tyr Phe Thr His Asp Met Ser Arg Asp Phe
345 350 355GGG TTT TCC AAC CAA TAC CAA AGC GTG TAT ATG AGC AGT CAA AAC AAG 1579Gly Phe Ser Asn Gln Tyr Gln Ser Val Tyr Met Ser Ser Gln Asn Lys
360 365 370ATT TTA CCT TTT AAA GGC AAG GGA AAA ATT AGC GCG ACT AAC CCT AAT 1627Ile Leu Pro Phe Lys Gly Lys Gly Lys Ile Ser Ala Thr Asn Pro Asn375 380 385 390TGC GGT TTG TAT TCT TAT AGC GAC ACG AAC AGC CCT TGT TGG CAA TTT 1675Cys Gly Leu Tyr Ser Tyr Ser Asp Thr Asn Ser Pro Cys Trp Gln Phe
395 400 405TTT GAC AAT ATC CGC CGA TCC GTG GTG AAT GCC TTT GAG CCA AAA CTC 1723Phe Asp Asn Ile Arg Arg Ser Val Val Asn Ala Phe Glu Pro Lys Leu
410 415 420AAT CTT ATC GTC AAT ACC GGT AAA GTC AAA CAA ACT TTT AAT ATG GGA 1771Asn Leu Ile Val Asn Thr Gly Lys Val Lys Gln Thr Phe Asn Met Gly
425 430 435ATG CGC TTT TTA ACT GAA GAT TTA TAC CGC CGA TCC ACC ACC AGG AAA 1819Met Arg Phe Leu Thr Glu Asp Leu Tyr Arg Arg Ser Thr Thr ArgLys
440 445 450AAC CCT AGC ATG CCT AAT AAT GGG AGT GGT TTT GAT GCA GGA ACT TCA 1867Asn Pro Ser Met Pro Asn Asn Gly Ser Gly Phe Asp Ala Gly Thr Ser455 460 465 470CTC AAT AAT TTC AAC AAT TAT ACC GCT GTG TAT GCC AGC GAT GAG ATC 1915Leu Asn Asn Phe Asn Asn Tyr Thr Ala Val Tyr Ala Ser Asp Glu Ile
475 480 485AAT TTC AAT AAC GGC ATG CTA ACG ATC ACG CCG GGC TTG AGA TAC ACT 1963Asn Phe Asn Asn Gly Met Leu Thr Ile Thr Pro Gly Leu Arg Tyr Thr
490 495 500TTT TTA AAT TAC GAA AAA AAA GAC GCT CCT CCT TTT AAA GCA GGC CAA 2011Phe Leu Asn Tyr Glu Lys Lys Asp Ala Pro Pro Phe Lys Ala Gly Gln
505 510 515ACA GGA AAA ACC ATT AAA GAT CGT TAT AAC CAA TGG AAT CCA GCA GTG 2059Thr Gly Lys Thr Ile Lys Asp Arg Tyr Asn Gln Trp Asn Pro Ala Val
520 525 530AAT GTC GGC TAT AAA CCC ATT AAA GAA TTG TTG TTT TAT TTC AAT TAC 2107Asn Val Gly Tyr Lys Pro Ile Lys Glu Leu Leu Phe Tyr Phe Asn Tyr535 540 545 550CAA AGA AGC TAC ATT CCG CCT CAA TTC AGC AAT ATC GGT AGT TTT GTA 2155Gln Arg Ser Tyr Ile Pro Pro Gln Phe Ser Asn Ile Gly Ser Phe Val
555 560 565GGC ACA AGC ACG GAT TAT TTT CAA ATC TTT AAT GTC ATG GAA GGC GGC 2203Gly Thr Ser Thr Asp Tyr Phe Gln Ile Phe Asn Val Met Glu Gly Gly
570 575 580TCA AGA TAT TAT TTT AAC AAC CAA GTG AGT TTT AAC GCG AAT TAT TTT 2251Ser Arg Tyr Tyr Phe Asn Asn Gln Val Ser Phe Asn Ala Asn Tyr Phe
585 590 595GTG ATTTTT GCG AAT AAC TAT TTT ACC GGG CGC TAT GGG GAT AAT AAA 2299Val Ile Phe Ala Asn Asn Tyr Phe Thr Gly Arg Tyr Gly Asp Asn Lys
600 605 610GAG CCG GTC AAT GCG AGA TCG CAA GGC GTG GAG CTA GAG TTG TAT TAC 2347Glu Pro Val Asn Ala Arg Ser Gln Gly Val Glu Leu Glu Leu Tyr Tyr615 620 625 630ACG CCG ATT AGA GGG CTT AAT TTC CAT GCG GCT TAC ACT TTC ATA GAT 2395Thr Pro Ile Arg Gly Leu Asn Phe His Ala Ala Tyr Thr Phe Ile Asp
635 640 645GCC AAT ATC ACA AGC CAC ACG ATG GTT ACT AAC CCC GCT AAT CCT AAA 2443Ala Asn Ile Thr Ser His Thr Met Val Thr Asn Pro Ala Asn Pro Lys
650 655 660GGG CCT AAA AAA GAT ATT TTT GGC AAA AAG CTC CCT TTT GTA AGC CCG 2491Gly Pro Lys Lys Asp Ile Phe Gly Lys Lys Leu Pro Phe Val Ser Pro
665 670 675CAC CAA TTC ATT TTA GAC GCG AGC TAC ACT TAC GCT AAA ACC ACG ATT 2539His Gln Phe Ile Leu Asp Ala Ser Tyr Thr Tyr Ala Lys Thr Thr Ile
680 685 690GGG TTG AGT TCT TTC TTT TAT AGC CGA ACT TAT AGC GAT GTG TTA AAC 2587Gly Leu Ser Ser Phe Phe Tyr Ser Arg Thr Tyr Ser Asp Val Leu Asn695 700 705 710ACC GTG CCT TTT ATT CAA TAC GCG CCC ACG ATC AAA AAT GGT GCT ATC 2635Thr Val Pro Phe Ile Gln Tyr Ala Pro Thr Ile Lys Asn Gly Ala Ile
715 720 725ACT ACC AAA ACA GCG GGC ATG ACG CCA TGG TAT TGG GTG TGG AAT TTG 2683Thr Thr Lys Thr Ala Gly Met Thr Pro Trp Tyr Trp Val Trp Asn Leu
730 735 740CAA ATT TCT ACC ACT TTT TGG GAA CGC AAA AAG CAA AGC GTT AAT GCG 2731Gln Ile Ser Thr Thr Phe Trp Glu Arg Lys Lys Gln Ser ValAsn Ala
745 750 755AGC TTG CAA ATC AAT AAC ATT TTT AAC ATG AAA TAT TGG TTT AGC GGG 2779Ser Leu Gln Ile Asn Asn Ile Phe Asn Met Lys Tyr Trp Phe Ser Gly
760 765 770ATA GGC ACT AGC CTA ACG GGA AAG AAG CCG CGC CTC CTA GGA GCA TCA 2827Ile Gly Thr Ser Leu Thr Gly Lys Lys Pro Arg Leu Leu Gly Ala Ser775 780 785 790CAG CGT ATG TGAGCTATCA TTTTTAATTT TAGGGTTGTA ATGTTTTGAG AAGTTGGGC 2885Gln Arg MetGTAAA 2890
(2) Sequence 362 data:
(i) sequence characteristics:
(A) length: 793 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 362: met Arg Lys Val Ile Thr Met Asn Gly Tyr Leu Arg Val Lys Thr Ser 151015 Tyr Phe Leu Ala Leu Asn Ala Leu Thr Phe Leu Ser Phe Asn Ser Leu
20 25 30Val Gly Ala Lys Glu Gln His His Thr Leu Gln Lys Val Thr Thr Thr
35 40 45Glu Gln Lys Phe Asn Pro Ser Ala Pro Leu Ser Trp Gln Ser Glu Glu
50 55 60Met Arg Asn Ser Thr Ser Ser Arg Thr Val Ile Ser Asn Lys Glu Leu65 70 75 80Lys Lys Thr Gly Asn Leu Asn Ile Glu Asn Ala Leu Gln Asn Val Pro
85 9095Gly Ile Gln Ile Arg Asp Ala Thr Gly Thr Gly Val Leu Pro Lys Ile
100 105 110Ser Val Arg Gly Phe Gly Gly Gly Gly Asn Gly His Ser Asn Thr Asn
115 120 125Met Ile Leu Val Asn Gly Ile Pro Ile Tyr Gly Ala Pro Tyr Ser Asn
130 135 140Ile Glu Leu Ala Ile Phe Pro Val Thr Phe Gln Ser Val Asp Arg Ile145 150 155 160Asp Val Ile Lys Gly Gly Thr Ser Val Gln Tyr Gly Pro Asn Thr Phe
165 170 175Gly Gly Val Val Asn Ile Ile Thr Lys Glu Ile Pro Lys Glu Trp Glu
180 185 190Asn Gln Ala Ala Glu Arg Ile Thr Phe Trp Gly Arg Ser Ser Asn Gly
195 200 205Asn Phe Val Asp Pro Lys Glu Lys Gly Lys Pro Leu Ala Gln Thr Leu
210 215 220Gly Asn Gln Met Leu Phe Asn Thr Tyr Gly Arg Thr Ala Gly Met Leu225 230 235 240Gly Lys His Val Gly Ile Ser Ala Gln Gly Asn Trp Ile Asn Gly Gln
245 250 255Gly Phe Arg Gln Asn Ser Pro Thr Lys Val Gln Asn Tyr Leu Leu Asp
260 265 270Ala Val Tyr Lys Ile Asn Ala Thr Asn Thr Phe Lys Ala Tyr Tyr Gln
275 280 285Tyr Tyr Gln Tyr Asn Ser Tyr His Pro Gly Thr Leu Ser Ala Gln Asp
290 295 300Tyr Ala Tyr Asn Arg Phe Ile Asn Glu Arg Pro Asp Asn Gln Asp Gly305 310 315 320Gly Arg Ala Lys ArgPhe Gly Ile Val Tyr Gln Asn Tyr Phe Gly Asp
325 330 335Pro Asp Arg Lys Val Gly Gly Asp Phe Lys Phe Thr Tyr Phe Thr His
340 345 350Asp Met Ser Arg Asp Phe Gly Phe Ser Asn Gln Tyr Gln Ser Val Tyr
355 360 365Met Ser Ser Gln Asn Lys Ile Leu Pro Phe Lys Gly Lys Gly Lys Ile
370 375 380Ser Ala Thr Asn Pro Asn Cys Gly Leu Tyr Ser Tyr Ser Asp Thr Asn385 390 395 400Ser Pro Cys Trp Gln Phe Phe Asp Asn Ile Arg Arg Ser Val Val Asn
405 410 415Ala Phe Glu Pro Lys Leu Asn Leu Ile Val Asn Thr Gly Lys Val Lys
420 425 430Gln Thr Phe Asn Met Gly Met Arg Phe Leu Thr Glu Asp Leu Tyr Arg
435 440 445Arg Ser Thr Thr Arg Lys Asn Pro Ser Met Pro Asn Asn Gly Ser Gly
450 455 460Phe Asp Ala Gly Thr Ser Leu Asn Asn Phe Asn Asn Tyr Thr Ala Val465 470 475 480Tyr Ala Ser Asp Glu Ile Asn Phe Asn Asn Gly Met Leu Thr Ile Thr
485 490 495Pro Gly Leu Arg Tyr Thr Phe Leu Asn Tyr Glu Lys Lys Asp Ala Pro
500 505 510Pro Phe Lys Ala Gly Gln Thr Gly Lys Thr Ile Lys Asp Arg Tyr Asn
515 520 525Gln Trp Asn Pro Ala Val Asn Val Gly Tyr Lys Pro Ile Lys Glu Leu
530 535 540Leu Phe Tyr Phe Asn Tyr Gln Arg Ser Tyr Ile Pro Pro Gln Phe Ser545 550 555 560Asn Ile Gly Ser Phe Val Gly Thr Ser Thr Asp Tyr Phe Gln Ile Phe
565 570 575Asn Val Met Glu Gly Gly Ser Arg Tyr Tyr Phe Asn Asn Gln Val Ser
580 585 590Phe Asn Ala Asn Tyr Phe Val Ile Phe Ala Asn Asn Tyr Phe Thr Gly
595 600 605Arg Tyr Gly Asp Asn Lys Glu Pro Val Asn Ala Arg Ser Gln Gly Val
610 615 620Glu Leu Glu Leu Tyr Tyr Thr Pro Ile Arg Gly Leu Asn Phe His Ala625 630 635 640Ala Tyr Thr Phe Ile Asp Ala Asn Ile Thr Ser His Thr Met Val Thr
645 650 655Asn Pro Ala Asn Pro Lys Gly Pro Lys Lys Asp Ile Phe Gly Lys Lys
660 665 670Leu Pro Phe Val Ser Pro His Gln Phe Ile Leu Asp Ala Ser Tyr Thr
675 680 685Tyr Ala Lys Thr Thr Ile Gly Leu Ser Ser Phe Phe Tyr Ser Arg Thr
690 695 700Tyr Ser Asp Val Leu Asn Thr Val Pro Phe Ile Gln Tyr Ala Pro Thr705 710 715 720Ile Lys Asn Gly Ala Ile Thr Thr Lys Thr Ala Gly Met Thr Pro Trp
725 730 735Tyr Trp Val Trp Asn Leu Gln Ile Ser Thr Thr Phe Trp Glu Arg Lys
740 745 750Lys Gln Ser Val Asn Ala Ser Leu Gln Ile Asn Asn Ile Phe Asn Met
755 760 765Lys Tyr Trp Phe Ser Gly Ile Gly Thr Ser Leu Thr Gly Lys Lys Pro
770 775 780Arg Leu Leu Gly Ala Ser Gln Arg Met785 790
(2) Sequence 363 data:
(i) sequence characteristics:
(A) length: 406bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...353
(D) Other information:
(xi) Description of the sequence: sequence 363: TCGTCTTTTG TCGGTTCAAA AAAATCTCTC GACTTAAAAA AACCTATTAA ATC AAG 56
Ile Lys
1ATA ATC TAT CAA ATC ATC AAG TTT TTT CGT TCT AAG AAT TTT ATT TTG 104Ile Ile Tyr Gln Ile Ile Lys Phe Phe Arg Ser Lys Asn Phe Ile Leu
5 10 15TTT TTT AGA ATA GCA ACG ATA AAG TTC TTC TTT TAT CTC ATT TGG GAA 152Phe Phe Arg Ile Ala Thr Ile Lys Phe Phe Phe Tyr Leu Ile Trp Glu
20 25 30TTT TTG AAT GTT ATA GAC AAT TTC ACT ATC TCT TTG ATT TTG TTT ATA 200Phe Leu Asn Val Ile Asp Asn Phe Thr Ile Ser Leu Ile Leu Phe Ile35 40 45 50TTT TTT AGC CCC ATA CCA AAG AAA TAT TTG ATA AAA AAT AAG AAA AAT 248Phe Phe Ser Pro Ile Pro Lys Lys Tyr Leu Ile Lys Asn Lys Lys Asn
55 6065AGC GTA AAA GAA AAA GAA AAT AAA GAA AAA AGA AAG AGA AAA AGA AAG 296Ser Val Lys Glu Lys Glu Asn Lys Glu Lys Arg Lys Arg Lys Arg Lys
70 75 80GAT TTT GTT TTG GGT GTA TTG GAA AAT AGA CTC AAA AAT CAA TTG AAA 344Asp Phe Val Leu Gly Val Leu Glu Asn Arg Leu Lys Asn Gln Leu Lys
85 90 95AAC CCC TTT TAGATTAAAA ATAAAAACAA TAAGCGAAAC GACAAAAGCA AGCAGAAAA 402Asn Pro Phe
100GAAG 406
(2) Sequence 364 data:
(i) sequence characteristics:
(A) length: 101 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 364: ile Lys Ile Ile Tyr Gln Ile Ile Lys Phe Phe Arg Ser Lys Asn Phe 151015 Ile Leu Phe Phe Arg Ile Ala Thr Ile Lys Phe Phe Phe Tyr Leu Ile
20 25 30Trp Glu Phe Leu Asn Val Ile Asp Asn Phe Thr Ile Ser Leu Ile Leu
35 40 45Phe Ile Phe Phe Ser Pro Ile Pro Lys Lys Tyr Leu Ile Lys Asn Lys
50 55 60Lys Asn Ser Val Lys Glu Lys Glu Asn Lys Glu Lys Arg Lys Arg Lys65 70 75 80Arg Lys Asp Phe Val Leu Gly Val Leu Glu Asn Arg Leu Lys Asn Gln
85 90 95Leu Lys Asn Pro Phe
100
(2) Data for sequence 365:
(i) sequence characteristics:
(A) length: 1143bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 89...1087
(D) Other information:
(xi) Description of the sequence: sequence 365: GATTTTGTGA AAAATAGTTT CATTTTTACT GCTTGTATTT CCTTAATGGT GTTATAATCG 60CTCCATAAAT CATACAAAAA GGATCGTT ATG TTA GTT ACT CGC TTT AAA AAA 112
Met Leu Val Thr Arg Phe Lys Lys
1 5GCT TTA ATC TCT TAT TCT TTA GGC GCG CTT CTT GTT TCA TCG TTA TTG 160Ala Leu Ile Ser Tyr Ser Leu Gly Ala Leu Leu Val Ser Ser Leu Leu
10 15 20GGC GTG GCT AGT GCT TCC AAT CAA GAA ATC CAA GTC AAA GAT TAT TTT 208Gly Val Ala Ser Ala Ser Asn Gln Glu Ile Gln Val Lys Asp Tyr Phe25 30 35 40GGG GAT CAA GCC ATC AAG CTT CCT GTT TCT AAA ATA ATC TAC TTG GGT 256Gly Asp Gln Ala Ile Lys Leu Pro Val Ser Lys Ile Ile Tyr Leu Gly
45 50 55AGC TTT GCA GAA GTG CCT GCT ATG TTC CAT ACT TGG GAT AGG GTC GTG 304Ser Phe Ala Glu Val Pro Ala Met Phe His Thr Trp Asp Arg Val Val
60 65 70GGA ATT TCG GAT TAC GCT TTT AAA TCT GAT ATT GTT AAA GCT ACT CTC 352Gly Ile Ser Asp Tyr Ala Phe Lys Ser Asp Ile Val Lys Ala Thr Leu
75 80 85AAA GAT CCT AAA CGC ATT AAA TCC ATG AGC AGT GAT CAT GTG GCG GCG 400Lys Asp Pro Lys Arg Ile Lys Ser Met Ser Ser Asp His Val Ala Ala
90 95 100TTG AAT GTG GAG CTT TTA AAA AAG CTT GGC CCC GAT CTT GTG GTA ACC 448Leu Asn Val Glu Leu Leu Lys Lys Leu Gly Pro Asp Leu Val Val Thr105 110 115 120TTT GTG GGC AAC CCT AAA GCG GTA GAG CAT GCG AAA AAA TTT GGT ATA 496Phe Val Gly Asn Pro Lys Ala Val Glu His Ala Lys Lys Phe Gly Ile
125 130 135TTA TTT CTT TCT TTC CAA GAA AAA ACC ATT GCA GAA GTC ATG GAA GAT 544Leu Phe Leu Ser Phe Gln Glu Lys Thr Ile Ala Glu Val Met Glu Asp
140 145 150ATT GAC GCT CAA GCT AAA GCC TTA GAA ATT GAT GCT TCT AAA AAA CTG 592Ile Asp Ala Gln Ala Lys Ala Leu Glu Ile Asp Ala Ser Lys Lys Leu
155 160 165GCC AAA ATG CAA GAA ACT TTG GAT TTT ATT GCT GAG CGT TTG AAA GGT 640Ala Lys Met Gln Glu Thr Leu Asp Phe Ile Ala Glu Arg Leu Lys Gly
170 175 180GTC AAA AAG AAA AAA GGG GTG GAG CTT TTC CAT AAG GCC AAT AAG ATC 688Val Lys Lys Lys Lys Gly Val Glu Leu Phe His Lys Ala Asn Lys Ile185 190 195 200AGC GGC CAT CAA GCC CTT GAT TCA GAC ATT TTA GAA AAA GGA GGC ATA 736Ser Gly His Gln Ala Leu Asp Ser Asp Ile Leu Glu Lys Gly Gly Ile
205 210 215GAC AAT TTT GGC TTG AAA TAT GTC AAA TTT GGG CGT GCT GAC ATT AGC 784Asp Asn Phe Gly Leu Lys Tyr Val Lys Phe Gly Arg Ala Asp Ile Ser
220 225 230GTG GAA AAA ATC GTT AAA GAA AAC CCT GAG ATT ATC TTT ATT TGG TGG 832Val Glu Lys Ile Val Lys Glu Asn Pro Glu Ile Ile Phe Ile Trp Trp
235 240 245ATA AGC CCA CTC ACG CCT GAA GAT GTG TTA AAC AAC CCC AAA TTT GCT 880Ile Ser Pro Leu Thr Pro Glu Asp Val Leu Asn Asn Pro Lys Phe Ala
250 255 260ACC ATC AAA GCC ATT AAA AAC AAG CAG GTT TAT AAA CTC CCC ACA ATG 928Thr Ile Lys Ala Ile Lys Asn Lys Gln Val Tyr Lys Leu Pro Thr Met265 270 275 280GAT ATT GGC GGG CCT AGA GCC CCA CTC ATA AGT CTT TTT ATC GCT CTA 976Asp Ile Gly Gly Pro Arg Ala Pro Leu Ile Ser Leu Phe Ile Ala Leu
285 290 295AAA GCC CAC CCT GAA GCC TTT AAG GGC GTG GAT ATT AAT GCG ATT GTT 1024Lys Ala His Pro Glu Ala Phe Lys Gly Val Asp lle Asn Ala Ile Val
300 305 310AAA GAC TAC TAT AAA GTG GTT TTT GAT TTG AAT GAT GCA GAG GTT GAA 1072Lys Asp Tyr Tyr Lys Val Val Phe Asp Leu Asn Asp Ala Glu Val Glu
315 320 325CCC TTT TTA TGG CAT TAATTTTTAA AAAAGGGCTG ATATTTTTAG CCCTTTGTGT A 1128Pro Phe Leu Trp His
330TCGCGCTAGG ATTAG 1143
(2) Sequence 366 data:
(i) sequence characteristics:
(A) length: 333 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type:protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 366: met Leu Val Thr Arg Phe Lys Lys Ala Leu Ile Ser Tyr Ser Leu Gly 151015 Ala Leu Leu Val Ser Ser Leu Leu Gly Val Ala Ser Ala Ser Asn Gln
20 25 30Glu Ile Gln Val Lys Asp Tyr Phe Gly Asp Gln Ala Ile Lys Leu Pro
35 40 45Val Ser Lys Ile Ile Tyr Leu Gly Ser Phe Ala Glu Val Pro Ala Met
50 55 60Phe His Thr Trp Asp Arg Val Val Gly Ile Ser Asp Tyr Ala Phe Lys65 70 75 80Ser Asp Ile Val Lys Ala Thr Leu Lys Asp Pro Lys Arg Ile Lys Ser
85 90 95Met Ser Ser Asp His Val Ala Ala Leu Asn Val Glu Leu Leu Lys Lys
100 105 110Leu Gly Pro Asp Leu Val Val Thr Phe Val Gly Asn Pro Lys Ala Val
115 120 125Glu His Ala Lys Lys Phe Gly Ile Leu Phe Leu Ser Phe Gln Glu Lys
130 135 140Thr Ile Ala Glu Val Met Glu Asp Ile Asp Ala Gln Ala Lys Ala Leu145 150 155 160Glu Ile Asp Ala Ser Lys Lys Leu Ala Lys Met Gln Glu Thr Leu Asp
165 170 175Phe Ile Ala Glu Arg Leu Lys Gly Val Lys Lys Lys Lys Gly Val Glu
180 185 190Leu Phe His Lys Ala Asn Lys Ile Ser Gly His Gln Ala Leu Asp Ser
195 200 205Asp Ile Leu Glu Lys Gly Gly Ile Asp Asn Phe Gly Leu Lys Tyr Val
210 215 220Lys Phe Gly Arg Ala Asp Ile Ser Val Glu Lys Ile ValLys Glu Asn225 230 235 240Pro Glu Ile Ile Phe Ile Trp Trp Ile Ser Pro Leu Thr Pro Glu Asp
245 250 255Val Leu Asn Asn Pro Lys Phe Ala Thr Ile Lys Ala Ile Lys Asn Lys
260 265 270Gln Val Tyr Lys Leu Pro Thr Met Asp Ile Gly Gly Pro Arg Ala Pro
275 280 285Leu Ile Ser Leu Phe Ile Ala Leu Lys Ala His Pro Glu Ala Phe Lys
290 295 300Gly Val Asp Ile Asn Ala Ile Val Lys Asp Tyr Tyr Lys Val Val Phe305 310 315 320Asp Leu Asn Asp Ala Glu Val Glu Pro Phe Leu Trp His
325 330
(2) Sequence 367 data:
(i) sequence characteristics:
(A) length: 898bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...845
(D) Other information:
(xi) Description of the sequence: sequence 367: GGGGGGTTAT AGTAAAAACA TGCAAGTAAT TTAAAGTTAA TTTAAGATAA TTA GGC 56
Leu Gly
1ACA ATA GCC ACA AAA AGT TTA AGG CTG TAT TTG AAA ACT CTA TTT AGT 104Thr Ile Ala Thr Lys Ser Leu Arg Leu Tyr Leu Lys Thr Leu Phe Ser
5 10 15ATT TAT CTC TTT TTA TCG TTG AAC CCA CTC TTT TTA GAA GCT AAT GAA 152Ile Tyr Leu Phe Leu Ser Leu Asn Pro Leu Phe Leu Glu Ala Asn Glu
20 25 30ATC ACT TGG TCT AAA TTC TTG GAA AAT TTT AAA AAC AAG AAT GAT GAT 200Ile Thr Trp Ser Lys Phe Leu Glu Asn Phe Lys Asn Lys Asn Asp Asp35 40 45 50GAC AAA CCT AAA CCC CTA ACT ATT GAT AAA AAC AAT GAA AAA CAG CAA 248Asp Lys Pro Lys Pro Leu Thr Ile Asp Lys Asn Asn Glu Lys Gln Gln
55 60 65ATC TTA GAC AAA AAC CAG CAA ATC TTA AAA AGG GCT TTG GAA AAA AGC 296Ile Leu Asp Lys Asn Gln Gln Ile Leu Lys Arg Ala Leu Glu Lys Ser
70 75 80CTT AAA TTC TTT TTC ATT TTT GGA TAC AAC TAT TCG CAA GCC ACT TTT 344Leu Lys Phe Phe Phe Ile Phe Gly Tyr Asn Tyr Ser Gln Ala Thr Phe
85 90 95TCA ACT TCT AAC CAA ACC TTG ACT TTT GTA GCC AAT AGC ATA GGG TTT 392Ser Thr Ser Asn Gln Thr Leu Thr Phe Val Ala Asn Ser Ile Gly Phe
100 105 110AAC ACC GCT ACC GGT TTA GAG CAT TTT TTA AGA AAC CAC CCT AAA GTC 440Asn Thr Ala Thr Gly Leu Glu His Phe Leu Arg Asn His Pro Lys Val115 120 125 130GGT TTT AGA ATC TTT AGC GTC TAT AAC TAT TTC CAT TCT GTT TCC CTC 488Gly Phe Arg Ile Phe Ser Val Tyr Asn Tyr Phe His Ser Val Ser Leu
135 140 145TCC CAG CCT CAA ACC TTA ATG GTG CAA AAT TAT GGG GGC GCG TTA GAT 536Ser Gln Pro Gln Thr Leu Met Val Gln Asn Tyr Gly Gly Ala Leu Asp
150 155 160TTT TCT TGG ATT TTT GTA GAT AAA AAT ATT TAT CGC TTT AGG AGT TAT 584Phe Ser Trp Ile Phe Val Asp Lys Asn Ile Tyr Arg Phe Arg Ser Tyr
165 170 175TTA GGG ATC GCT TTA GAA CAA GGG GTG TTG TTA GTG GAT ACG ATT AAA 632Leu Gly Ile Ala Leu Glu Gln Gly Val Leu Leu Val Asp Thr Ile Lys
180 185 190CCA GGT GCT ATC ACA ACG ATT ATC CCA AGA ACC AAA AAA ACC TTT TTT 680Pro Gly Ala Ile Thr Thr Ile Ile Pro Arg Thr Lys Lys Thr Phe Phe195 200 205 210CAA GCC CCT TTG CGT TTT GGT TTT ATC GTG GAT TTT ATC GGC TAT TTG 728Gln Ala Pro Leu Arg Phe Gly Phe Ile Val Asp Phe Ile Gly Tyr Leu
215 220 225TCT TTG CAA TTA GGG ATT GAA ATG CCT TTA GTG AGG AAT GTT TTT TAC 776Ser Leu Gln Leu Gly Ile Glu Met Pro Leu Val Arg Asn Val Phe Tyr
230 235 240ACC TAC AAC AAC CAT CAA GAA AGA TTC AAA CCA CGA TTT AAC GCT AAT 824Thr Tyr Asn Asn His Gln Glu Arg Phe Lys Pro Arg Phe Asn Ala Asn
245 250 255CTT TCT TTA ATC GTT TCG TTT TAGCCCCCCT TTTCCCCTTT TAAATAAGCC CATG 879Leu Ser Leu Ile Val Ser Phe
260 265ATTTTCCTAG GGTATTTTA 898
(2) Sequence 368 data:
(i) sequence characteristics:
(A) length: 265 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 368: leu Gly Thr Ile Ala Thr Lys Ser Leu Arg Leu Tyr Leu Lys Thr Leu 151015 Phe Ser Ile Tyr Leu Phe Leu Ser Leu Asn Pro Leu Phe Leu Glu Ala
20 25 30Asn Glu Ile Thr Trp Ser Lys Phe Leu Glu Asn Phe Lys Asn Lys Asn
35 40 45Asp Asp Asp Lys Pro Lys Pro Leu Thr Ile Asp Lys Asn Asn Glu Lys
50 55 60Gln Gln Ile Leu Asp Lys Asn Gln Gln Ile Leu Lys Arg Ala Leu Glu65 70 75 80Lys Ser Leu Lys Phe Phe Phe Ile Phe Gly Tyr Asn Tyr Ser Gln Ala
85 90 95Thr Phe Ser Thr Ser Asn Gln Thr Leu Thr Phe Val Ala Asn Ser Ile
100 105 110Gly Phe Asn Thr Ala Thr Gly Leu Glu His Phe Leu Arg Asn His Pro
115 120 125Lys Val Gly Phe Arg Ile Phe Ser Val Tyr Asn Tyr Phe His Ser Val
130 135 140Ser Leu Ser Gln Pro Gln Thr Leu Met Val Gln Asn Tyr Gly Gly Ala145 150 155 160Leu Asp Phe Ser Trp Ile Phe Val Asp Lys Asn Ile Tyr Arg Phe Arg
165 170 175Ser Tyr Leu Gly Ile Ala Leu Glu Gln Gly Val Leu Leu Val Asp Thr
180 185 190Ile Lys Pro Gly Ala Ile Thr Thr Ile Ile Pro Arg Thr Lys Lys Thr
195 200 205Phe Phe Gln Ala Pro Leu Arg Phe Gly Phe Ile Val Asp Phe Ile Gly
210 215 220Tyr Leu Ser Leu Gln Leu Gly Ile Glu Met Pro Leu Val Arg Asn Val225 230 235 240Phe Tyr Thr Tyr Asn Asn His Gln Glu Arg Phe Lys Pro Arg Phe Asn
245 250 255Ala Asn Leu Ser Leu Ile Val Ser Phe
260 265
(2) Sequence 369 data:
(i) sequence characteristics:
(A) length: 742bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...689
(D) Other information:
(xi) Description of the sequence: sequence 369: GCACTTCACG CATTCCATAA ACGATATTGA TTATTTGCTA GACAGCTTGA AAA AAG 56
Lys Lys
1CAG TTA AAA AAT TGC GTT AAG CTA AAA CTA TTT TTA AGG AAA AAT TTG 104Gln Leu Lys Asn Cys Val Lys Leu Lys Leu Phe Leu Arg Lys Asn Leu
5 10 15GAT ATT TTA GAT TTG AAC AAA GCG CAA GCG GTG CAA CAA AAT GAA CAA 152Asp Ile Leu Asp Leu Asn Lys Ala Gln Ala Val Gln Gln Asn Glu Gln
20 25 30GAG GTA GAG GAT AAA GAG CGA GAG TCT AAA GAG CCG GTG GTT TTA GAA 200Glu Val Glu Asp Lys Glu Arg Glu Ser Lys Glu Pro Val Val Leu Glu35 40 45 50GAT TTG AGC GCT TTA GCG TGG CTT GAA TTA GAA GAG TTT AGC CGC CTT 248Asp Leu Ser Ala Leu Ala Trp Leu Glu Leu Glu Glu Phe Ser Arg Leu
55 60 65TCA GGG CTT CCT AAA GAA AGG ATT TTG GAA TTA GTG AAT CTT GGT AAA 296Ser Gly Leu Pro Lys Glu Arg Ile Leu Glu Leu Val Asn Leu Gly Lys
70 75 80ATC AAG AGC AAA ATA AGC AGC AAC AAG CTT TTA ATT GAT GCG AGC AGC 344Ile Lys Ser Lys Ile Ser Ser Asn Lys Leu Leu Ile Asp Ala Ser Ser
85 90 95GGG ACA AAC GCT TTA ATC AAA AAG GTA GAA AAT AGT TTG ATT TCT ATG 392Gly Thr Asn Ala Leu Ile Lys Lys Val Glu Asn Ser Leu Ile Ser Met
100 105 110GAT ATG AAC GGG CGT TCT TTA GAA CCT GTG TTT GTG GAA AAG ACC ATT 440Asp Met Asn Gly Arg Ser Leu Glu Pro Val Phe Val Glu Lys Thr Ile115 120 125 130AAC ACG ATT TTA AAC TTG CAT GAT AAG GTC ATT GGC GCT AAA GAT GAA 488Asn Thr Ile Leu Asn Leu His Asp Lys Val Ile Gly Ala Lys Asp Glu
135 140 145ACG ATT TCA GCC TTT AAA AAT GAA AAC ATG TTT TTA AAA GAC GCT TTA 536Thr Ile Ser Ala Phe Lys Asn Glu Asn Met Phe Leu Lys Asp Ala Leu
150 155 160ATC TCT ATG CAA GAA GTC TAT GAA GAA GAT AAA AAA ACC ATT GAT CTT 584Ile Ser Met Gln Glu Val Tyr Glu Glu Asp Lys Lys Thr Ile Asp Leu
165 170 175TTG CGC GAT GAA CTC AAT CAA GCG AGA GAA GAA ATT GAA TTT ATG AAG 632Leu Arg Asp Glu Leu Asn Gln Ala Arg Glu Glu Ile Glu Phe Met Lys
180 185 190AGG AAA TAC CGC TTG ATG TGG GGG AAA GTC GCT GAC ATG AGC AGC GTG 680Arg Lys Tyr Arg Leu Met Trp Gly Lys Val Ala Asp Met Ser Ser Val195 200 205 210AAT AAA AAG TAGTTTTAAA TTAACGCCCA TGCTGAGGGC TTATTAGCGG TAATTTTAG 738Asn Lys LysGTGA 742
(2) Sequence 370 data:
(i) sequence characteristics:
(A) length: 213 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 370: lys Lys Gln Leu Lys Asn Cys Val Lys Leu Lys Leu Phe Leu Arg Lys 151015 Asn Leu Asp Ile Leu Asp Leu Asn Lys Ala Gln Ala Val Gln Gln Asn
20 25 30Glu Gln Glu Val Glu Asp Lys Glu Arg Glu Ser Lys Glu Pro Val Val
35 40 45Leu Glu Asp Leu Ser Ala Leu Ala Trp Leu Glu Leu Glu Glu Phe Ser
50 55 60Arg Leu Ser Gly Leu Pro Lys Glu Arg Ile Leu Glu Leu Val Asn Leu65 70 75 80Gly Lys Ile Lys Ser Lys Ile Ser Ser Asn Lys Leu Leu Ile Asp Ala
85 90 95Ser Ser Gly Thr Asn Ala Leu Ile Lys Lys Val Glu Asn Ser Leu Ile
100 105 110Ser Met Asp Met Asn Gly Arg Ser Leu Glu Pro Val Phe Val Glu Lys
115 120 125Thr Ile Asn Thr Ile Leu Asn Leu His Asp Lys Val Ile Gly Ala Lys
130 135 140Asp Glu Thr Ile Ser Ala Phe Lys Asn Glu Asn Met Phe Leu Lys Asp145 150 155 160Ala Leu Ile Ser Met Gln Glu Val Tyr Glu Glu Asp Lys Lys Thr Ile
165 170 175Asp Leu Leu Arg Asp Glu Leu Asn Gln Ala Arg Glu Glu Ile Glu Phe
180 185 190Met Lys Arg Lys Tyr Arg Leu Met Trp Gly Lys Val Ala Asp Met Ser
195 200 205Ser Val Asn Lys Lys
210
(2) Sequence 371 data:
(i) sequence characteristics:
(A) length: 1004bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 56...931
(D) Other information:
(xi) Description of the sequence: sequence 371: CATTAAACGC ATGATTTTTG CTACAATAAT AGGATTTTAA TTATATAAAG GACAA ATG 58
Met
1GGC ATG CCA AAT AGG GGC GTT GTT TTA TTA GAC GGG CAA GCG CTA GCT 106Gly Met Pro Asn Arg Gly Val Val Leu Leu Asp Gly Gln Ala Leu Ala
5 10 15GAT AAT ATA GAA AAA GAT TTG AAA CAT AAA ATC CAA ATA ATA ACC GCA 154Asp Asn Ile Glu Lys Asp Leu Lys His Lys Ile Gln Ile Ile Thr Ala
20 25 30CAA ACG CAT AAA CGC CCC AAA CTA GCC GTG ATT TTA GTG GGG AAA GAT 202Gln Thr His Lys Arg Pro Lys Leu Ala Val Ile Leu Val Gly Lys Asp
35 40 45CCC GCT AGT ATC ACT TAT GTC AAT ATG AAG ATC AAA GCA TGC GAA AGG 250Pro Ala Ser Ile Thr Tyr Val Asn Met Lys Ile Lys Ala Cys Glu Arg50 55 60 65GTG GGC ATG GAT TTT GAC TTA AAA ACC CTC CAA GAA AAT ATT ACT GAA 298Val Gly Met Asp Phe Asp Leu Lys Thr Leu Gln Glu Asn Ile Thr Glu
70 75 80GCC AAA TTG CTA TCC TTG ATT AAA GAT TAC AAT ACC GAT CAA AAC ATT 346Ala Lys Leu Leu Ser Leu Ile Lys Asp Tyr Asn Thr Asp Gln Asn Ile
85 90 95TCA GGC GTT TTA GTC CAG CTC CCT TTG CCC AGA CAC ATT GAT ACT AAA 394Ser Gly Val Leu Val Gln Leu Pro Leu Pro Arg His Ile Asp Thr Lys
100 105 110ATG ATT TTA GAA GCC ATT GAC CCA AAC AAA GAT GTG GAT GGT TTC CAC 442Met Ile Leu Glu Ala Ile Asp Pro Asn Lys Asp Val Asp Gly Phe His
115 120 125CCC CTT AAT ATC GGT AAG CTC TGC ACT CAA AAA GAA TCG TTT CTG CCA 490Pro Leu Asn Ile Gly Lys Leu Cys Thr Gln Lys Glu Ser Phe Leu Pro130 135 140 145GCC ACC CCT ATG GGC GTG ATG CGG CTT TTA GAG CAT TAC CAT ATT GAA 538Ala Thr Pro Met GlyVal Met Arg Leu Leu Glu His Tyr His Ile Glu
150 155 160ATC AAG GGT AAG GAT GTG GCG ATT ATT GGA GCG AGC AAT ATC ATT GGC 586Ile Lys Gly Lys Asp Val Ala Ile Ile Gly Ala Ser Asn Ile Ile Gly
165 170 175AAA CCT TTA AGC ATG CTC ATG CTA AAC GCT GGG GCT AGC GTG AGC GTG 634Lys Pro Leu Ser Met Leu Met Leu Asn Ala Gly Ala Ser Val Ser Val
180 185 190TGC CAT ATT TTG ACT AAA GAC ATT AGT TTT TAC ACC CAA AAC GCT GAT 682Cys His Ile Leu Thr Lys Asp Ile Ser Phe Tyr Thr Gln Asn Ala Asp
195 200 205ATT GTC TGC GTG GGC GTG GGT AAA CCT GAT TTG ATT AAA GCG AGC ATG 730Ile Val Cys Val Gly Val Gly Lys Pro Asp Leu Ile Lys Ala Ser Met210 215 220 225TTA AAA AAA GGG GCT GTA GTG GTG GAT ATT GGG ATC AAT CAT TTG AAC 778Leu Lys Lys Gly Ala Val Val Val Asp Ile Gly Ile Asn His Leu Asn
230 235 240GAT GGG CGT ATC GTG GGC GAT GTG GAT TTT AAC AAC GTG CAA AAA GTC 826Asp Gly Arg Ile Val Gly Asp Val Asp Phe Asn Asn Val Gln Lys Val
245 250 255GCC GGT TTT ATC ACC CCT GTG CCT AAA GGC GTG GGG CCT ATG ACG ATT 874Ala Gly Phe Ile Thr Pro Val Pro Lys Gly ValGly Pro Met Thr Ile
260 265 270GTC TCG CTT TTA GAA AAC ACT CTA ATC GCT TTT GAA AAA CAA CAA AGG 922Val Ser Leu Leu Glu Asn Thr Leu Ile Ala Phe Glu Lys Gln Gln Arg
275 280 285AAG GGA TTT TAATGAAATT TTTACGCTCT GTTTATGCAT TTTGCTCCAG TTGGGTAGG 980Lys Gly Phe290GACGATTGTT ATTGTGCTGT TGGT1004
(2) Sequence 372 data:
(i) sequence characteristics:
(A) length: 292 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 372: met Gly Met Pro Asn Arg Gly Val Val Leu Leu Asp Gly Gln Ala Leu 151015 Ala Asp Asn Ile Glu Lys Asp Leu Lys His Lys Ile Gln Ile Ile Thr
20 25 30Ala Gln Thr His Lys Arg Pro Lys Leu Ala Val Ile Leu Val Gly Lys
35 40 45Asp Pro Ala Ser Ile Thr Tyr Val Asn Met Lys Ile Lys Ala Cys Glu
50 55 60Arg Val Gly Met Asp Phe Asp Leu Lys Thr Leu Gln Glu Asn Ile Thr65 70 75 80Glu Ala Lys Leu Leu Ser Leu Ile Lys Asp Tyr Asn Thr Asp Gln Asn
85 90 95Ile Ser Gly Val Leu Val Gln Leu Pro Leu Pro Arg His Ile Asp Thr
100 105 110Lys Met Ile Leu Glu Ala Ile Asp Pro Asn Lys Asp Val Asp Gly Phe
115 120 125His Pro Leu Asn Ile Gly Lys Leu Cys Thr Gln Lys Glu Ser Phe Leu
130 135 140Pro Ala Thr Pro Met Gly Val Met Arg Leu Leu Glu His Tyr His Ile145 150 155 160Glu Ile Lys Gly Lys Asp Val Ala Ile Ile Gly Ala Ser Asn Ile Ile
165 170 175Gly Lys Pro Leu Ser Met Leu Met Leu Asn Ala Gly Ala Ser Val Ser
180 185 190Val Cys His Ile Leu Thr Lys Asp Ile Ser Phe Tyr Thr Gln Asn Ala
195 200 205Asp Ile Val Cys Val Gly Val Gly Lys Pro Asp Leu Ile Lys Ala Ser
210 215 220Met Leu Lys Lys Gly Ala Val Val Val Asp Ile Gly Ile Asn His Leu225 230 235 240Asn Asp Gly Arg Ile Val Gly Asp Val Asp Phe Asn Asn Val Gln Lys
245 250 255Val Ala Gly Phe Ile Thr Pro Val Pro Lys Gly Val Gly Pro Met Thr
260 265 270Ile Val Ser Leu Leu Glu Asn Thr Leu Ile Ala Phe Glu Lys Gln Gln
275 280 285Arg Lys Gly Phe
290
(2) Data of sequence 373:
(i) sequence characteristics:
(A) length: 2162bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 66...2099
(D) Other information:
(xi) Description of the sequence: sequence 373: CCCTTGCTTC TTTTTGTCTT TTTTAAGACT TTATCTCTTG TTAAAAAAAG GTTGTATTAA 60CGCTT ATG AAA TCC CTA TCT AAT GCC CTT TTT TCG CTC TTT TTA AAA GGT 110
Met Lys Ser Leu Ser Asn Ala Leu Phe Ser Leu Phe Leu Lys Gly
1 5 10 15TTT TAT TTC ACC TTT TTT ATG AGC TTG TTG TTT GTG TTT AAT CGT ATC 158Phe Tyr Phe Thr Phe Phe Met Ser Leu Leu Phe Val Phe Asn Arg Ile
20 25 30GGC TTT ATC CTT TAT ACT GGC TAT TAT AAG CAT GCT TTA AAA AAC CCT 206Gly Phe Ile Leu Tyr Thr Gly Tyr Tyr Lys His Ala Leu Lys Asn Pro
35 40 45GTT TTT GAT GAA ATC ATC AAA ACC CTA TTC AAT GGA GCC AGA TAT GAT 254Val Phe Asp Glu Ile Ile Lys Thr Leu Phe Asn Gly Ala Arg Tyr Asp
50 55 60AAT CGT GTG GTC TCA AGC TTA GCG ATT CTT TTT ATC ATC ATC GGG TTA 302Asn Arg Val Val Ser Ser Leu Ala Ile Leu Phe Ile Ile Ile Gly Leu
65 70 75TTG GGG TTA TTT ATC CCT AAA CAC CAA ACC AAA ATG CTT AAT ATT GTG 350Leu Gly Leu Phe Ile Pro Lys His Gln Thr Lys Met Leu Asn Ile Val80 85 90 95GCG TAT TTT TCT ATC GCT ATT ATC CTG TTT TTA AAC ATT GCA AAC ATT 398Ala Tyr Phe Ser Ile Ala Ile Ile Leu Phe Leu Asn Ile Ala Asn Ile
100 105 110GTT TAT TAT GGT ATT TAT GGG AAT GTG TTT GAT GAA AAT TTA TTG GAA 446Val Tyr Tyr Gly Ile Tyr Gly Asn Val Phe Asp Glu Asn Leu Leu Glu
115 120 125TTT TTG CAT GAA GAC ACG CTC ACG ATT TTA AAA ATG AGC GGG GAA TAC 494Phe Leu His Glu Asp Thr Leu Thr Ile Leu Lys Met Ser Gly Glu Tyr
130 135 140CCT ATT TTTTCT AGT TTT TCA CTC TTT TTA ATC CTT AGC GTT TTA ACC 542Pro Ile Phe Ser Ser Phe Ser Leu Phe Leu Tle Leu Ser Val Leu Thr
145 150 155TCT TTT ATC TAT TTC AAA CTC CAA AAC GAC CTT TTT AAA CCC AAA AAT 590Ser Phe Ile Tyr Phe Lys Leu Gln Asn Asp Leu Phe Lys Pro Lys Asn160 165 170 175GCT TAT CAA GCC GCC CAC ACC AAA CCC CTT AAA ACT TTC ATT TTA TTT 638Ala Tyr Gln Ala Ala His Thr Lys Pro Leu Lys Thr Phe Ile Leu Phe
180 185 190GCG CTT TTT TCC CTC ACA CAA ATG TTT TAC ATT AAC GCG CAA TTG AGT 686Ala Leu Phe Ser Leu Thr Gln Met Phe Tyr Ile Asn Ala Gln Leu Ser
195 200 205TTT GTG GGC GCG TCT TTA GAT CTC AGC ATA GAG CCA GCC AAA GAT CCT 734Phe Val Gly Ala Ser Leu Asp Leu Ser Ile Glu Pro Ala Lys Asp Pro
210 215 220TTT TTA ATG AAA ATT ACC CCC GGA GCG TTT CGC AAC CTT TAT CTT TTA 782Phe Leu Met Lys Ile Thr Pro Gly Ala Phe Arg Asn Leu Tyr Leu Leu
225 230 235GCA CGC AAT TAC AGA CAA AGC CAT AAC CTT AAA TTC AGC GAT TTT GCT 830Ala Arg Asn Tyr Arg Gln Ser His Asn Leu Lys Phe Ser Asp Phe Ala240 245 250 255AAA GAA ACG CCT TTA GAA GTG GCG AAA AAT TAT TTC CAT CTT AAA GAG 878Lys Glu Thr Pro Leu Glu Val Ala Lys Asn Tyr Phe His Leu Lys Glu
260 265 270AAC CCT TCA AAC AAC CTC TAT GAG TTG CTA ACT CAG ACA AGC CGC AAC 926Asn Pro Ser Asn Asn Leu Tyr Glu Leu Leu Thr Gln Thr Ser Arg Asn
275 280 285AAT TCC AAT CAA ACC ATT CAA CAT GTT TTT TAT ATC GTT TCA GAG TCT 974Asn Ser Asn Gln Thr Ile GlnHis Val Phe Tyr Ile Val Ser Glu Ser
290 295 300TTG AGT TCA TGG CAT TTT GAT CCA AAA TTT GAC GCT ATA GGG CTA ACG 1022Leu Ser Ser Trp His Phe Asp Pro Lys Phe Asp Ala Ile Gly Leu Thr
305 310 315AGC GCT TTA CAA GAC TTG GTT AAA AAA GAG CAT GCC CAC ATG CTT TCT 1070Ser Ala Leu Gln Asp Leu Val Lys Lys Glu His Ala His Met Leu Ser320 325 330 335GCT TTT ATT GAA AGC GCC CCA CGG ACC GTT AAA AGC CTA GAT GTC CAA 1118Ala Phe Ile Glu Ser Ala Pro Arg Thr Val Lys Ser Leu Asp Val Gln
340 345 350ATC ACA GGC TTA CCC TAT ATC AAT GAT AAT AAC TTA GTC AAT TCA GGG 1166Ile Thr Gly Leu Pro Tyr Ile Asn Asp Asn Asn Leu Val Asn Ser Gly
355 360 365GTG ATC CTC CCT AGC TTT CCT ATG GCG ATT GGC AAT ATC ACA AAA ACT 1214Val Ile Leu Pro Ser Phe Pro Met Ala Ile Gly Asn Ile Thr Lys Thr
370 375 380CTG GGT TAT AAA AAC AAC TTT TAT TAT GGG GGT AGC GGG ATT TGG AAC 1262Leu Gly Tyr Lys Asn Asn Phe Tyr Tyr Gly Gly Ser Gly Ile Trp Asn
385 390 395AAA CTC ACT AGT TTC ACC AAA AAA CAA GGT TTT CAC GCC CTT TAT TTC 1310Lys Leu Thr Ser Phe Thr Lys Lys Gln Gly Phe His Ala Leu Tyr Phe400 405 410 415AAT AAC CAT CTC TTA GAA TTT GCC CAA AAC AAG CCC TAC CCT AAA CCC 1358Asn Asn His Leu Leu Glu Phe Ala Gln Asn Lys Pro Tyr Pro Lys Pro
420 425 430ATA GAG AGC AAC TGG GGA GTG CAT GAT AAT ATT TTA TTT GAC TAT ATT 1406Ile Glu Ser Asn Trp Gly Val His Asp Asn Ile Leu Phe Asp Tyr Ile
435 440445TTA GAA AAC ACC AAC CCC CAT GAA AAA ACT TTC AGC ATG GTC ATG ACT 1454Leu Glu Asn Thr Asn Pro His Glu Lys Thr Phe Ser Met Val Met Thr
450 455 460TTA AGC AAC CAT GCG ATC AAA AAC GTG AAT CTC AAA GCC TTT GGC GTG 1502Leu Ser Asn His Ala Ile Lys Asn Val Asn Leu Lys Ala Phe Gly Val
465 470 475CCT TTA GAA AAA ATC CAA CAA TTT GTG GAA AAA ACC CCC AAA TCA GAA 1550Pro Leu Glu Lys Ile Gln Gln Phe Val Glu Lys Thr Pro Lys Ser Glu480 485 490 495AAT TTA CCG GAC GCT AAT TCT TTA GGG CAT ATT TAC TGG TAT GAC AAA 1598Asn Leu Pro Asp Ala Asn Ser Leu Gly His Ile Tyr Trp Tyr Asp Lys
500 505 510GTA ATC GTC AGT TTC ATC AAA AAA GCC AGC CAA AAA TTC CCT AAC TCG 1646Val Ile Val Ser Phe Ile Lys Lys Ala Ser Gln Lys Phe Pro Asn Ser
515 520 525CTT TTT ATC ATC ACA GGG GAT CAT TTT GAC AGG AGC TAT GAA TAC GCT 1694Leu Phe Ile Ile Thr Gly Asp His Phe Asp Arg Ser Tyr Glu Tyr Ala
530 535 540AAA AAC GAT TTG TAT ATC ATT AAA TCC GTG CCG CTT ATT TTA TAT GCC 1742Lys Asn Asp Leu Tyr Ile Ile Lys Ser Val Pro Leu Ile Leu Tyr Ala
545 550 555CCT ACT TTA AAG CCT AAA AAA ATC AGT CAG GTC GGA TCG CAT TTA GAC 1790Pro Thr Leu Lys Pro Lys Lys Ile Ser Gln Val Gly Ser His Leu Asp560 565 570 575ATC GCC CCT ACG ATT ATT GAA TTA GTC GCC CCT AAA GGC TTT CAA TTC 1838Ile Ala Pro Thr Ile Ile Glu Leu Val Ala Pro Lys Gly Phe Gln Phe
580 585 590GTG AGT TTT GGG AAG CCT TTA TTT TCT AAC AAT ACA ACA AAC CCC CCA 1886Val Ser Phe Gly Lys Pro Leu Phe Ser Asn Asn Thr Thr Asn Pro Pro
595 600 605AGC CAC CCC AAT TAC GCG CTA GGC TAT GAA GCG ATC GCT ACC AAA GAT 1934Ser His Pro Asn Tyr Ala Leu Gly Tyr Glu Ala Ile Ala Thr Lys Asp
610 615 620TAT TTT TAT AAC CCA AGT TTG GGG TTA AGG TAT TTG AAC GAA AGC CCT 1982Tyr Phe Tyr Asn Pro Ser Leu Gly Leu Arg Tyr Leu Asn Glu Ser Pro
625 630 635AAA GAG CCA AAG GAT AAA CAA AAC GAC AAA ATA GAA GCT TCT AAG TTT 2030Lys Glu Pro Lys Asp Lys Gln Asn Asp Lys Ile Glu Ala Ser Lys Phe640 645 650 655TAT CAG CAA TTA GAA TCT TTG AAA GCC CTT AGT TAT TAC TTG CTC TAT 2078Tyr Gln Gln Leu Glu Ser Leu Lys Ala Leu Ser Tyr Tyr Leu Leu Tyr
660 665 670CAT GGG GCT AAT CTT AAA GAT TGACAAACTA GGTTTTTATT CCATTAAACG CATG 2133His Gly Ala Asn Leu Lys Asp
675ATTTTTGCTA CAATAATAGG ATTTTAATT 2162
(2) Sequence 374 data:
(i) sequence characteristics:
(A) length: 678 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 374: met Lys Ser Leu Ser Asn Ala Leu Phe Ser Leu Phe Leu Lys Gly Phe 151015 Tyr Phe Thr Phe Phe Met Ser Leu Leu Phe Val Phe Asn Arg Ile Gly
20 2530Phe Ile Leu Tyr Thr Gly Tyr Tyr Lys His Ala Leu Lys Asn Pro Val
35 40 45Phe Asp Glu Ile Ile Lys Thr Leu Phe Asn Gly Ala Arg Tyr Asp Asn
50 55 60Arg Val Val Ser Ser Leu Ala Ile Leu Phe Ile Ile Ile Gly Leu Leu65 70 75 80Gly Leu Phe Ile Pro Lys His Gln Thr Lys Met Leu Asn Ile Val Ala
85 90 95Tyr Phe Ser Ile Ala Ile Ile Leu Phe Leu Asn Ile Ala Asn Ile Val
100 105 110Tyr Tyr Gly Ile Tyr Gly Asn Val Phe Asp Glu Asn Leu Leu Glu Phe
115 120 125Leu His Glu Asp Thr Leu Thr Ile Leu Lys Met Ser Gly Glu Tyr Pro
130 135 140Ile Phe Ser Ser Phe Ser Leu Phe Leu Ile Leu Ser Val Leu Thr Ser145 150 155 160Phe Ile Tyr Phe Lys Leu Gln Asn Asp Leu Phe Lys Pro Lys Asn Ala
165 170 175Tyr Gln Ala Ala His Thr Lys Pro Leu Lys Thr Phe Ile Leu Phe Ala
180 185 190Leu Phe Ser Leu Thr Gln Met Phe Tyr Ile Asn Ala Gln Leu Ser Phe
195 200 205Val Gly Ala Ser Leu Asp Leu Ser Ile Glu Pro Ala Lys Asp Pro Phe
210 215 220Leu Met Lys Ile Thr Pro Gly Ala Phe Arg Asn Leu Tyr Leu Leu Ala225 230 235 240Arg Asn Tyr Arg Gln Ser His Asn Leu Lys Phe Ser Asp Phe Ala Lys
245 250255Glu Thr Pro Leu Glu Val Ala Lys Asn Tyr Phe His Leu Lys Glu Asn
260 265 270Pro Ser Asn Asn Leu Tyr Glu Leu Leu Thr Gln Thr Ser Arg Asn Asn
275 280 285Ser Asn Gln Thr Ile Gln His Val Phe Tyr Ile Val Ser Glu Ser Leu
290 295 300Ser Ser Trp His Phe Asp Pro Lys Phe Asp Ala Ile Gly Leu Thr Ser305 310 315 320Ala Leu Gln Asp Leu Val Lys Lys Glu His Ala His Met Leu Ser Ala
325 330 335Phe Ile Glu Ser Ala Pro Arg Thr Val Lys Ser Leu Asp Val Gln Ile
340 345 350Thr Gly Leu Pro Tyr Ile Asn Asp Asn Asn Leu Val Asn Ser Gly Val
355 360 365Ile Leu Pro Ser Phe Pro Met Ala Ile Gly Asn Ile Thr Lys Thr Leu
370 375 380Gly Tyr Lys Asn Asn Phe Tyr Tyr Gly Gly Ser Gly Ile Trp Asn Lys385 390 395 400Leu Thr Ser Phe Thr Lys Lys Gln Gly Phe His Ala Leu Tyr Phe Asn
405 410 415Ash His Leu Leu Glu Phe Ala Gln Asn Lys Pro Tyr Pro Lys Pro Ile
420 425 430Glu Ser Asn Trp Gly Val His Asp Asn Ile Leu Phe Asp Tyr Ile Leu
435 440 445Glu Asn Thr Asn Pro His Glu Lys Thr Phe Ser Met Val Met Thr Leu
450 455 460Ser Asn His Ala Ile Lys Asn Val Asn Leu Lys Ala Phe Gly Val Pro465 470 475 480Leu Glu Lys Ile Gln Gln Phe Val Glu Lys Thr Pro Lys Ser Glu Asn
485 490 495Leu Pro Asp Ala Asn Ser Leu Gly His Ile Tyr Trp Tyr Asp Lys Val
500 505 510Ile Val Ser Phe Ile Lys Lys Ala Ser Gln Lys Phe Pro Asn Ser Leu
515 520 525Phe Ile Ile Thr Gly Asp His Phe Asp Arg Ser Tyr Glu Tyr Ala Lys
530 535 540Asn Asp Leu Tyr Ile Ile Lys Ser Val Pro Leu Ile Leu Tyr Ala Pro545 550 555 560Thr Leu Lys Pro Lys Lys Ile Ser Gln Val Gly Ser His Leu Asp Ile
565 570 575Ala Pro Thr Ile Ile Glu Leu Val Ala Pro Lys Gly Phe Gln Phe Val
580 585 590Ser Phe Gly Lys Pro Leu Phe Ser Asn Asn Thr Thr Asn Pro Pro Ser
595 600 605His Pro Asn Tyr Ala Leu Gly Tyr Glu Ala Ile Ala Thr Lys Asp Tyr
610 615 620Phe Tyr Asn Pro Ser Leu Gly Leu Arg Tyr Leu Asn Glu Ser Pro Lys625 630 635 640Glu Pro Lys Asp Lys Gln Asn Asp Lys Ile Glu Ala Ser Lys Phe Tyr
645 650 655Gln Gln Leu Glu Ser Leu Lys Ala Leu Ser Tyr Tyr Leu Leu Tyr His
660 665 670Gly Ala Asn Leu Lys Asp
675
(2) Sequence 375 data:
(i) sequence characteristics:
(A) length: 1573bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1520
(D) Other information:
(xi) Description of the sequence: sequence 375: TAGCCCACAG CTCTAGCGTT TTGCCTAACA TGAATCTATA AGGGGGATGC ATG GAT 56
Met Asp
1AAA GAA ACC CGA TTT TAC AAC CTT TTT TCT TTG GCA ATT TTA GGG ATT 104Lys Glu Thr Arg Phe Tyr Asn Leu Phe Ser Leu Ala Ile Leu Gly Ile
5 10 15TTG ATC TTT CCT GTG GGT TTG GCG AAT TTT TAT TTT GGC TAT GTT TTG 152Leu Ile Phe Pro Val Gly Leu Ala Asn Phe Tyr Phe Gly Tyr Val Leu
20 25 30AAA GAT TCG CCT TGT ATT TTT TGC TGG GCG CAA CGC ATC AAC ATG ATT 200Lys Asp Ser Pro Cys Ile Phe Cys Trp Ala Gln Arg Ile Asn Met Ile35 40 45 50TTA ATA GGG GCT GTG GCG CTT TTG GTG GTG CGT TTT GGG TTT AAG CCT 248Leu Ile Gly Ala Val Ala Leu Leu Val Val Arg Phe Gly Phe Lys Pro
55 60 65AAA TAC ATT GCC TTG CTG TTG CTT ATG GCT AGT AGC GGG TTA TAT GAG 296Lys Tyr Ile Ala Leu Leu Leu Leu Met Ala Ser Ser Gly Leu Tyr Glu
70 75 80AGC TTT TAT CAT ACC GGT AGC CAT GCT TTA GAA GAT GTG GGG CAG GGA 344Ser Phe Tyr His Thr Gly Ser His Ala Leu Glu Asp Val Gly Gln Gly
85 90 95TTC GCG CTC GCT ATT TTG GGC TTG CAC ACG CAG TTT TGG GCG CTT TTT 392Phe Ala Leu Ala Ile Leu Gly Leu His Thr Gln Phe Trp Ala Leu Phe
100 105 110GTC TTT TTT AGC GTG GTG GTG CTT TTA GCG GTT TTG CTC TTT TTT GCC 440Val Phe Phe Ser Val Val Val Leu Leu Ala Val Leu Leu Phe Phe Ala115 120 125 130CCT AAT GCC CAA CCT TTC AAA GAT CAT TCG TTA AAC GCG CTC CAA AAA 488Pro Asn Ala Gln Pro Phe Lys Asp His Ser Leu Asn Ala Leu Gln Lys
135 140 145ATC GCT TTT TAT GTT TTC TTT ATG GTG GTT GGT TCT AAC GCC GTG CAA 536Ile Ala Phe Tyr Val Phe Phe Met Val Val Gly Ser Asn Ala Val Gln
150 155 160GCG TTT ATT TCT ACC GGG CCT TTC CCT TAC ATA GGG CAA AGC GAT CCG 584Ala Phe Ile Ser Thr Gly Pro Phe Pro Tyr Ile Gly Gln Ser Asp Pro
165 170 175GTG CGT TTT TCG TGG AAT TTG AAA GAA TCG GTC TGG TCT ATG GAG AAT 632Val Arg Phe Ser Trp Asn Leu Lys Glu Ser Val Trp Ser Met Glu Asn
180 185 190TGG GAT CAT TTG AAA TTC CCA AGA AGC GTT TTG GGC AGA AGG GAT GTG 680Trp Asp His Leu Lys Phe Pro Arg Ser Val Leu Gly Arg Arg Asp Val195 200 205 210GGC GAG CCT TTG AAA TTG AGC GCT TTG CCT AAA GAT AAC GAT TAT GAG 728Gly Glu Pro Leu Lys Leu Ser Ala Leu Pro Lys Asp Asn Asp Tyr Glu
215 220 225GGT TCG CCT TTA GAA ATT ACA AAA ACT CTA AAG ATT GGA AAA AAA GAA 776Arg Ser Pro Leu Glu Ile Thr Lys Thr Leu Lys Ile Gly Lys Lys Glu
230 235 240GAG CTT TTT TTA AAA TTG AAT GGA GCG ATC ACG GAT TTG AGT TTC AAT 824Glu Leu Phe Leu Lys Leu Asn Gly Ala Ile Thr Asp Leu Ser Phe Asn
245 250 255GAA GAC AAG GCG ATT CTT ACC ACA GAA AAC CAA GGG CTT TAT CTT GTA 872Glu Asp Lys Ala Ile Leu Thr Thr Glu Asn Gln Gly Leu Tyr Leu Val
260 265 270AGT AAC GAT TTG AAA ACC ATT CAT AGC CAT ATG GTG TTG GAT AGC TAT 920Ser Asn Asp Leu Lys Thr Ile His Ser His Met Val Leu Asp Ser Tyr275 280 285 290TAT AGC GCG ACG GTG GGG TCG TTC GTG GGG GCG GAT TTC AAC GAA GAT 968Tyr Ser Ala Thr Val Gly Ser Phe Val Gly Ala Asp Phe Asn Glu Asp
295 300 305GAA AAC ATT GTG ATC ATG GGC AAT AAT AAA ACG AGC GTG GAA ATC ACT 1016Glu Asn Ile Val Ile Met Gly Asn Asn Lys Thr Ser Val Glu Ile Thr
310 315 320CCT AAC AAA AAC GCT AAC ATG CTT AAA AAC TTC CCT TAT TTT TTA GAA 1064Pro Asn Lys Asn Ala Asn Met Leu Lys Asn Phe Pro Tyr Phe Leu Glu
325 330 335GGG GTC AAC TCT TTT GAC GAA GTG GAA CGC AGC CGC TTG AAA ACT TCT 1112Gly Val Asn Ser Phe Asp Glu Val Glu Arg Ser Arg Leu Lys Thr Ser
340 345 350AGG GCG AAA AAC TAT TAT GTT AGC GTT GCA AGA AGA GGG GCT AAA TTC 1160Arg Ala Lys Asn Tyr Tyr Val Ser Val Ala Arg Arg Gly Ala Lys Phe355 360 365 370ACT TAT TTG ATC AGC GCT CCT AAC AAG CGT TAT AAG GAT TTG ATT ATT 1208Thr Tyr Leu Ile Ser Ala Pro Asn Lys Arg Tyr Lys Asp Leu Ile Ile
375 380 385ATT TCC ATG CGT AAT AGC GAT AAA CAG GTG CAT GGG GAG TTT TTA CTG 1256Ile Ser Met Arg Asn Ser Asp Lys Gln Val His Gly Glu Phe Leu Leu
390 395 400GAA TTA GGC AAT GCC AAA CTT AAA GAA AAA AGG GGA TTG GGC GAG TTA 1304Glu Leu Gly Asn Ala Lys Leu Lys Glu Lys Arg Gly Leu Gly Glu Leu
405 410 415GTC ATT AGC ACT TTG GCT TTA AAG GAT AAT AAA CTT TAT GCG TTC AGT 1352Val Ile Ser Thr Leu Ala Leu Lys Asp Asn Lys Leu Tyr Ala Phe Ser
420 425 430AAG GAA TTT AAC ACG CTT TTA GTC ATA GAC CCT ACA AAA GAA GAG ATT 1400Lys Glu Phe Asn Thr Leu Leu Val Ile Asp Pro Thr Lys Glu Glu Ile435 440 445 450CTT GAA GTT TAT GGC TTG CCT AAA GAG ATT AAA AAT ATC AGT GCT GGA 1448Leu Glu Val Tyr Gly Leu Pro Lys Glu Ile Lys Asn Ile Ser Ala Gly
455 460 465GGG TTT AGA AAC GAT GAG CTT GTC CTT GTG AGC TAT GAG AAT AAT AAA 1496Gly Phe Arg Asn Asp Glu Leu Val Leu Val Ser Tyr Glu Asn Asn Lys
470 475 480AAT ATT CTC TAC ACC CTT AAT TTT TAAACTCTTT TAAAGCTACT TTTTTCTAAT 1550Asn Ile Leu Tyr Thr Leu Asn Phe
485 490ATATTAACGC ATTAGAAGAT GGT 1573
(2) Data for sequence 376:
(i) sequence characteristics:
(A) length: 490 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 376: met Asp Lys Glu Thr Arg Phe Tyr Asn Leu Phe Ser Leu Ala Ile Leu 151015 Gly Ile Leu Ile Phe Pro Val Gly Leu Ala Asn Phe Tyr Phe Gly Tyr
20 25 30Val Leu Lys Asp Ser Pro Cys Ile Phe Cys Trp Ala Gln Arg Ile Asn
35 40 45Met Ile Leu Ile Gly Ala Val Ala Leu Leu Val Val Arg Phe Gly Phe
50 55 60Lys Pro Lys Tyr Ile Ala Leu Leu Leu Leu Met Ala Ser Ser Gly Leu65 70 75 80Tyr Glu Ser Phe Tyr His Thr Gly Ser His Ala Leu Glu Asp Val Gly
85 90 95Gln Gly Phe Ala Leu Ala Ile Leu Gly Leu His Thr Gln Phe Trp Ala
100 105 110Leu Phe Val Phe Phe Ser Val Val Val Leu Leu Ala Val Leu Leu Phe
115 120 125Phe Ala Pro Asn Ala Gln Pro Phe Lys Asp His Ser Leu Asn Ala Leu
130 135 140Gln Lys Ile Ala Phe Tyr ValPhe Phe Met Val Val Gly Ser Asn Ala145 150 155 160ValGln Ala Phe Ile Ser Thr Gly Pro Phe Pro Tyr Ile Gly Gln Ser
165 170 175Asp Pro Val Arg Phe Ser Trp Asn Leu Lys Glu Ser Val Trp Ser Met
180 185 190Glu Asn Trp Asp His Leu Lys Phe Pro Arg Ser Val Leu Gly Arg Arg
195 200 205Asp Val Gly Glu Pro Leu Lys Leu Ser Ala Leu Pro Lys Asp Asn Asp
210 215 220Tyr Glu Arg Ser Pro Leu Glu Ile Thr Lys Thr Leu Lys Ile Gly Lys225230 235 240Lys Glu Glu Leu Phe Leu Lys Leu Asn Gly Ala Ile Thr Asp Leu Ser
245 250 255Phe Asn Glu Asp Lys Ala Ile Leu Thr Thr Glu Asn Gln Gly Leu Tyr
260 265 270Leu Val Ser Asn Asp Leu Lys Thr Ile His Ser His Met Val Leu Asp
275 280 285Ser Tyr Tyr Ser Ala Thr Val Gly Ser Phe Val Gly Ala Asp Phe Asn
290 295 300Glu Asp Glu Asn Ile Val Ile Met Gly Asn Asn Lys Thr Ser Val Glu305 310 315 320Ile Thr Pro Asn Lys Asn Ala Asn Met Leu Lys Asn Phe Pro Tyr Phe
325 330 335Leu Glu Gly Val Asn Ser Phe Asp Glu Val Glu Arg Ser Arg Leu Lys
340 345 350Thr Ser Arg Ala Lys Asn Tyr Tyr Val Ser Val Ala Arg Arg Gly Ala
355 360 365Lys Phe Thr Tyr Leu Ile Ser Ala Pro Asn Lys Arg Tyr Lys Asp Leu
370 375 380Ile Ile Ile Ser Met Arg Asn Ser Asp Lys Gln Val His Gly Glu Phe385 390 395 400Leu Leu Glu Leu Gly Asn Ala Lys Leu Lys Glu Lys Arg Gly Leu Gly
405 410 415Glu Leu Val Ile Ser Thr Leu Ala Leu Lys Asp Asn Lys Leu Tyr Ala
420 425 430Phe Ser Lys Glu Phe Asn Thr Leu Leu Val Ile Asp Pro Thr Lys Glu
435 440 445Glu Ile Leu Glu ValTyr Gly Leu Pro Lys Glu Ile Lys Asn Ile Ser
450 455 460Ala Gly Gly Phe Arg Asn Asp Glu Leu Val Leu Val Ser Tyr Glu Asn465 470 475 480Asn Lys Asn Ile Leu Tyr Thr Leu Asn Phe
485 490
(2) Sequence 377 data:
(i) sequence characteristics:
(A) length: 679bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...626
(D) Other information:
(xi) Description of the sequence: sequence 377: TCTTAAAGAT TTATGTTACA CTCTGTGAAA TCAAAATCAA AGGGGATAGC GTG TTA 56
Val Leu
1GAA AAA TCT TTT TTA AAA AGC AAG CAA TTA TTT TTA TGC GGA CTG GGT 104Glu Lys Ser Phe Leu Lys Ser Lys Gln Leu Phe Leu Cys Gly Leu Gly
5 10 15GTT TTG ATG CTG CAG GCT TGC ACT TGC CCA AAC ACT TCA CAA AGG AAT 152Val Leu Met Leu Gln Ala Cys Thr Cys Pro Asn Thr Ser Gln Arg Asn
20 25 30TCT TTC TTG CAA GAT GTG CCT TAT TGG ATG TTG CAA AAT CGC AGT GAG 200Ser Phe Leu Gln Asp Val Pro Tyr Trp Met Leu Gln Asn Arg Ser Glu35 40 45 50TAT ATC ACG CAA GGG GTG GAT AGC TCG CAC ATT GTA GAT GGT AAG AAA 248Tyr Ile Thr Gln Gly Val Asp Ser Ser His Ile Val Asp Gly Lys Lys
55 60 65ACT GAA GAG ATA GAA AAA ATC GCT ACC AAA AGA GCG ACA ATA AGA GTG 296Thr Glu Glu Ile Glu Lys Ile Ala Thr Lys Arg Ala Thr Ile Arg Val
70 75 80GCA CAA AAT ATT GTG CAT AAA CTT AAA GAA GCT TAC CTT TCC AAA ACC 344Ala Gln Asn Ile Val His Lys Leu Lys Glu Ala Tyr Leu Ser Lys Thr
85 90 95AAT CGC ATC AAG CAA AAG ATC ACT AAT GAA ATG TTT ATC CAA ATG ACA 392Asn Arg Ile Lys Gln Lys Ile Thr Asn Glu Met Phe Ile Gln Met Thr
100 105 110CAG CCC ATT TAT GAC AGC TTG ATG AAT GTG GAT CGT TTA GGG ATT TAT 440Gln Pro Ile Tyr Asp Ser Leu Met Asn Val Asp Arg Leu Gly Ile Tyr115 120 125 130ATC AAT CCT AAC AAT GAG GAA GTG TTT GCG TTA GTG CGC GCG CGT GGT 488Ile Asn Pro Asn Asn Glu Glu Val Phe Ala Leu Val Arg Ala Arg Gly
135 140 145TTT GAT AAG GAC GCT TTG AGC GAA GGG TTG CAT AAA ATG TCC TTA GAC 536Phe Asp Lys Asp Ala Leu Ser Glu Gly Leu His Lys Met Ser Leu Asp
150 155 160AAT CAA GCG GTG AGT ATC CTT GTG GCT AAA GTG GAA GAA ATC TTT AAA 584Asn Gln Ala Val Ser Ile Leu Val Ala Lys Val Glu Glu Ile Phe Lys
165 170 175GAT TCT GTC AAT TAC GGA GAT GTT AAA GTC CCT ATA GCC ATG TAGGCTTAG 635Asp Ser Val Asn Tyr Gly Asp Val Lys Val Pro Ile Ala Met
180 185 190AACAACAAGC GTTCCTCGCT ATCGTCTGTT CTTTTGGGGG TGGG 679
(2) Sequence 378 data:
(i) sequence characteristics:
(A) length: 192 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 378: val Leu Glu Lys Ser Phe Leu Lys Ser Lys Gln Leu Phe Leu Cys Gly 151015 Leu Gly Val Leu Met Leu Gln Ala Cys Thr Cys Pro Asn Thr Ser Gln
20 25 30Arg Asn Ser Phe Leu Gln Asp Val Pro Tyr Trp Met Leu Gln Asn Arg
35 40 45Ser Glu Tyr Ile Thr Gln Gly Val Asp Ser Ser His Ile Val Asp Gly
50 55 60Lys Lys Thr Glu Glu Ile Glu Lys Ile Ala Thr Lys Arg Ala Thr Ile65 70 75 80Arg Val Ala Gln Asn Ile Val His Lys Leu Lys Glu Ala Tyr Leu Ser
85 90 95Lys Thr Asn Arg Ile Lys Gln Lys Ile Thr Asn Glu Met Phe Ile Gln
100 105 110Met Thr Gln Pro Ile Tyr Asp Ser Leu Met Asn Val Asp Arg Leu Gly
115 120 125Ile Tyr Ile Asn Pro Asn Asn Glu Glu Val Phe Ala Leu Val Arg Ala
130 135 140Arg Gly Phe Asp Lys Asp Ala Leu Ser Glu Gly Leu His Lys Met Ser145 150 155 160Leu Asp Asn Gln Ala Val Ser Ile Leu Val Ala Lys Val Glu Glu Ile
165170 175Phe Lys Asp Ser Val Asn Tyr Gly Asp Val Lys Val Pro Ile Ala Met
180 185 190
(2) Sequence 379 data:
(i) sequence characteristics:
(A) length: 2386bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...2333
(D) Other information:
(xi) Description of the sequence: sequence 379: TGGGGCTTTT TGGCGATGGG TTTATCCAAA CGAAATAATA GGATATTTTG ATG TAT 56
Met Tyr
1AAA ACA GCG ATT AAT CGT CCT ATT ACG ACC TTA ATG TTT GCT TTG GCG 104Lys Thr Ala Ile Asn Arg Pro Ile Thr Thr Leu Met Phe Ala Leu Ala
5 10 15ATT GTC TTT TTT GGG ACT ATG GGG TTT AAA AAA TTG AGC GTG GCG CTT 152Ile Val Phe Phe Gly Thr Met Gly Phe Lys Lys Leu Ser Val Ala Leu
20 25 30TTC CCT AAA ATT GAT TTG CCT ACG GTG GTG GTT ACT ACG ACT TAT CCT 200Phe Pro Lys Ile Asp Leu Pro Thr Val Val Val Thr Thr Thr Tyr Pro35 40 45 50GGG GCT AGC GCT GAA ATC ATA GAG AGT AAG GTA ACC GAT AAG ATT GAA 248Gly Ala Ser Ala Glu Ile Ile Glu Ser Lys Val Thr Asp Lys Ile Glu
55 60 65GAA GCG GTG ATG GGG ATT GAT GGG ATC AAA AAG GTT ACT TCC ACG AGT 296Glu Ala Val Met Gly Ile Asp Gly Ile Lys Lys Val Thr Ser Thr Ser
70 75 80TCT AAA AAT GTG AGT ATC GTC GTC ATT GAA TTT GAG TTA GAA AAA CCT 344Ser Lys Asn Val Ser Ile Val Val Ile Glu Phe Glu Leu Glu Lys Pro
85 90 95AAT GAA GAA GCC TTA AAC GAT GTG GTG AAT AAA ATT TCT TCG GTG CGT 392Asn Glu Glu Ala Leu Asn Asp Val Val Asn Lys Ile Ser Ser Val Arg
100 105 110TTT GAT GAC TCT AAC ATT AAA AAA CCC TCT ATC AAT AAA TTT GAT ACC 440Phe Asp Asp Ser Asn Ile Lys Lys Pro Ser Ile Asn Lys Phe Asp Thr115 120 125 130GAC AGC CAA GCC ATT ATT TCA TTG TTT GTG AGC AGT TCA AGC GTG CCG 488Asp Ser Gln Ala Ile Ile Ser Leu Phe Val Ser Ser Ser Ser Val Pro
135 140 145GCT ACA ACC CTT AAT GAC TAC GCT AAA AAC ACC ATC AAA CCC ATG CTC 536Ala Thr Thr Leu Asn Asp Tyr Ala Lys Asn Thr Ile Lys Pro Met Leu
150 155 160CAA AAA ATC AAT GGG GTA GGG GGC GTG CAG CTC AAC GGC TTT AGG GAG 584Gln Lys Ile Asn Gly Val Gly Gly Val Gln Leu Asn Gly Phe Arg Glu
165 170 175CGC CAG ATT AGG ATT TAT GCA AAT CCC ACT TTG ATG AAT AAA TAC AAC 632Arg Gln Ile Arg Ile Tyr Ala Asn Pro Thr Leu Met Asn Lys Tyr Asn
180 185 190CTG ACT TAT GCG GAT CTT TTC AGC ACG CTT AAA GCG GAG AAT GTG GAA 680Leu Thr Tyr Ala Asp Leu Phe Ser Thr Leu Lys Ala Glu Asn Val Glu195 200 205 210ATT GAT GGG GGG CGC ATT GTC AAT AGC CAA AGG GAA TTT TCT ATT TTA728Ile Asp Gly Gly Arg Ile Val Asn Ser Gln Arg Glu Phe Ser Ile Leu
215 220 225ATC AAT GCG AAT AGT TAT AGC GTT GCG GAT GTG GAA AAG ATT CAA GTG 776Ile Asn Ala Asn Ser Tyr Ser Val Ala Asp Val Glu Lys Ile Gln Val
230 235 240GGT AAT CAT GTG CGT CTT GGC GAT ATT GCA AAA ATT GAA ATC GGT TTG 824Gly Asn His Val Arg Leu Gly Asp Ile Ala Lys Ile Glu Ile Gly Leu
245 250 255GAA GAA GAC AAC ACT TTT GCG AGC TTT AAA GAC AAA CCC GGT GTG ATT 872Glu Glu Asp Asn Thr Phe Ala Ser Phe Lys Asp Lys Pro Gly Val Ile
260 265 270TTA GAA ATC CAA AAG ATT GCC GGA GCG AAT GAA ATT GAA ATC GTA GAT 920Leu Glu Ile Gln Lys Ile Ala Gly Ala Asn Glu Ile Glu Ile Val Asp275 280 285 290AGG GTG TAT GAA GCT TTA AAG CGC ATT CAA GCC ATT AGC CCT AAC TAT 968Arg Val Tyr Glu Ala Leu Lys Arg Ile Gln Ala Ile Ser Pro Asn Tyr
295 300 305GAA ATC AGA CCC TTT TTA GAC ACC ACG GGC TAT ATC CGC ACC TCT ATT 1016Glu Ile Arg Pro Phe Leu Asp Thr Thr Gly Tyr Ile Arg Thr Ser Ile
310 315 320GAA GAC GTG AAA TTT GAT CTA GTT TTA GGG GCG ATT TTA GCG GTT TTA 1064Glu Asp Val Lys Phe Asp Leu Val Leu Gly Ala Ile Leu Ala Val Leu
325 330 335GTG GTG TTT GCG TTC TTG CGT AAC GGC ACG ATC ACC CTC GTT TCA GCG 1112Val Val Phe Ala Phe Leu Arg Asn Gly Thr Ile Thr Leu Val Ser Ala
340 345 350ATC TCT ATC CCT ATT TCT ATC ATG GGG ACT TTT GCG CTC ATC CAA TGG 1160Ile Ser Ile Pro Ile Ser Ile Met Gly Thr Phe Ala Leu Ile Gln Trp355 360 365 370ATG GGC TTT TCA TTA AAC ATG CTC ACC ATG GTG GCT TTA ACG TTG GCG 1208Met Gly Phe Ser Leu Asn Met Leu Thr Met Val Ala Leu Thr Leu Ala
375 380 385ATA GGG ATT ATC ATT GAT GAT GCG ATC GTG GTG ATT GAA AAC ATC CAT 1256Ile Gly Ile Ile Ile Asp Asp Ala Ile Val Val Ile Glu Asn Ile His
390 395 400AAA AAG CTA GAA ATG GGC ATG AGT AAA CGA AAA GCG AGC TAT GAG GGG 1304Lys Lys Leu Glu Met Gly Met Ser Lys Arg Lys Ala Ser Tyr Glu Gly
405 410 415GTG AGA GAA ATT GGC TTT GCT CTA GTG GCG ATT TCA GCG ATG CTG CTC 1352Val Arg Glu Ile Gly Phe Ala Leu Val Ala Ile Ser Ala Met Leu Leu
420 425 430TCT GTT TTT GTG CCT ATA GGG AAC ATG AAA GGC ATT ATT GGG CGT TTT 1400Ser Val Phe Val Pro Ile Gly Asn Met Lys Gly Ile Ile Gly Arg Phe435 440 445 450TTT CAA AGT TTT GGG ATC ACG GTG GCT TTA GCG ATC GCT CTA TCG TAT 1448Phe Gln Ser Phe Gly Ile Thr Val Ala Leu Ala Ile Ala Leu Ser Tyr
455 460 465GTG GTG GTC GTT ACG ATT ATC CCC ATG GTA AGC TCA GTC GTG GTC AAT 1496Val Val Val Val Thr Ile Ile Pro Met Val Ser Ser Val Val Val Asn
470 475 480CCC AGG CAT TCT CGT TTT TAT GTG TGG AGT GAG CCT TTT TTT AAG GCT 1544Pro Arg His Ser Arg Phe Tyr Val Trp Ser Glu Pro Phe Phe Lys Ala
485 490 495TTA GAG TCT CGT TAT ACC AAG TTG CTC CAA TGG GTA TTA AAC CAC AAG 1592Leu Glu Ser Arg Tyr Thr Lys Leu Leu Gln Trp Val Leu Asn His Lys
500 505 510ATC ATT ATC TCT ATA GCG GTG GTT TTG GTG TTT GTG GGA TCG CTT TTT 1640Ile Ile Ile Ser Ile Ala Val Val Leu Val Phe Val Gly Ser Leu Phe515 520 525 530GTG GCT TCT AAG ATT GGT ATG GAG TTC ATG CTG AAA GAA GAT AGG GGG 1688Val Ala Ser Lys Ile Gly Met Glu Phe Met Leu Lys Glu Asp Arg Gly
535 540 545AGG TTT TTG GTG TGG CTT AAG GCT AAA CCG GGC GTG AGC ATA GAT TAC 1736Arg Phe Leu Val Trp Leu Lys Ala Lys Pro Gly Val Ser Ile Asp Tyr
550 555 560ATG ACA CAA AAG AGT AAG ATC TTT CAA AAA GCG ATT GAA AAA CAT GCT 1784Met Thr Gln Lys Ser Lys Ile Phe Gln Lys Ala Ile Glu Lys His Ala
565 570 575GAA GTG GAA TTC ACC ACC TTG CAA GTG GGT TAT GGC ACC ACA CAA AAC 1832Glu Val Glu Phe Thr Thr Leu Gln Val Gly Tyr Gly Thr Thr Gln Asn
580 585 590CCT TTT AAG GCT AAG ATT TTT GTG CAA CTC AAG CCT TTA AAA GAG CGT 1880Pro Phe Lys Ala Lys Ile Phe Val Gln Leu Lys Pro Leu Lys Glu Arg595 600 605 610AAA AAA GAG CAT CAA TTG GGG CAA TTT GAG TTG ATG AGC GTT TTA AGG 1928Lys Lys Glu His Gln Leu Gly Gln Phe Glu Leu Met Ser Val Leu Arg
615 620 625AAA GAG TTG AGA AGC TTG CCT GAA GCT AAA GGT TTA GAT ACT ATT AAT 1976Lys Glu Leu Arg Ser Leu Pro Glu Ala Lys Gly Leu Asp Thr Ile Asn
630 635 640CTT TCT GAA GTT ACT CTT ATA GGG GGC GGT GGG GAT AGT TCG CCC TTC 2024Leu Ser Glu Val Thr Leu Ile Gly Gly Gly Gly Asp Ser Ser Pro Phe
645 650 655CAA ACC TTT GTG TTT TCC CAT TCT CAA GAA GCG GTG GAT AAA AGC GTG 2072Gln Thr Phe Val Phe Ser His Ser Gln Glu Ala Val Asp Lys Ser Val
660 665 670GAG AAT TTG AAA AAA TTC TTA TTA GAA AGC CCT GAA TTA AAA GGC AAG 2120Glu Asn Leu Lys Lys Phe Leu Leu Glu Ser Pro Glu Leu Lys Gly Lys675 680 685 690GTT GAA AGC TAT CAT ACA AGC ACG AGC GAA TCG CAA CCG CAA TTG CAA 2168Val Glu Ser Tyr His Thr Ser Thr Ser Glu Ser Gln Pro Gln Leu Gln
695 700 705CTC AAA ATC TTA AGA CAA AAC GCT AAC AAA TAC GGC GTG AGC GCT CAA 2216Leu Lys Ile Leu Arg Gln Asn Ala Asn Lys Tyr Gly Val Ser Ala Gln
710 715 720ACC ATT GGA TCA GTG GTG AGC TCT GCT TTT TCT GGG ACT TCT CAA GCG 2264Thr Ile Gly Ser ValVal Ser Ser Ala Phe Ser Gly Thr Ser Gln Ala
725 730 735AGC GTG TTC AAA GAA GAT GGC AAA GAA TAC GAC ATG ATC TTA GAG TGC 2312Ser Val Phe Lys Glu Asp Gly Lys Glu Tyr Asp Met Ile Leu Glu Cys
740 745 750CTG ATG ACA AGC GCG TTT CTG TAGAAGACAT CAAACGCTTG CAAGTGCGTA ACAA 2367Leu Met Thr Ser Ala Phe Leu755 760ATACGATAAA TTGATGTTT 2386
(2) Sequence 380 data:
(i) sequence characteristics:
(A) length: 761 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 380: met Tyr Lys Thr Ala Ile AsnArg Pro Ile Thr Thr Leu Met Phe Ala 151015 Leu Ala Ile Val Phe Phe Gly Thr Met Gly Phe Lys Lys Leu Ser Val
20 25 30Ala Leu Phe Pro Lys Ile Asp Leu Pro Thr Val Val Val Thr Thr Thr
35 40 45Tyr Pro Gly Ala Ser Ala Glu Ile Ile Glu Ser Lys Val Thr Asp Lys
50 55 60Ile Glu Glu Ala Val Met Gly Ile Asp Gly Ile Lys Lys Val Thr Ser65 70 75 80Thr Ser Ser Lys Asn Val Ser Ile Val Val Ile Glu Phe Glu Leu Glu
85 90 95Lys Pro Asn Glu Glu Ala Leu Asn Asp Val Val Asn Lys Ile Ser Ser
100 105 110Val Arg Phe Asp Asp Ser Asn Ile Lys Lys Pro Ser Ile Asn Lys Phe
115 120 125Asp Thr Asp Ser Gln Ala Ile Ile Ser Leu Phe Val Ser Ser Ser Ser
130 135 140Val Pro Ala Thr Thr Leu Asn Asp Tyr Ala Lys Asn Thr Ile Lys Pro145 150 155 160Met Leu Gln Lys Ile Asn Gly Val Gly Gly Val Gln Leu Asn Gly Phe
165 170 175Arg Glu Arg Gln Ile Arg Ile Tyr Ala Asn Pro Thr Leu Met Asn Lys
180 185 190Tyr Asn Leu Thr Tyr Ala Asp Leu Phe Ser Thr Leu Lys Ala Glu Asn
195 200 205Val Glu Ile Asp Gly Gly Arg Ile Val Asn Ser Gln Arg Glu Phe Ser
210 215 220Ile Leu Ile Asn Ala Asn Ser Tyr Ser Val Ala Asp Val Glu Lys Ile225 230235 240Gln Val Gly Asn His Val Arg Leu Gly Asp Ile Ala Lys Ile Glu Ile
245 250 255Gly Leu Glu Glu Asp Asn Thr Phe Ala Ser Phe Lys Asp Lys Pro Gly
260 265 270Val Ile Leu Glu Ile Gln Lys Ile Ala Gly Ala Asn Glu Ile Glu Ile
275 280 285Val Asp Arg Val Tyr Glu Ala Leu Lys Arg Ile Gln Ala Ile Ser Pro
290 295 300Asn Tyr Glu Ile Arg Pro Phe Leu Asp Thr Thr Gly Tyr Ile Arg Thr305 310 315 320Ser Ile Glu Asp Val Lys Phe Asp Leu Val Leu Gly Ala Ile Leu Ala
325 330 335Val Leu Val Val Phe Ala Phe Leu Arg Asn Gly Thr Ile Thr Leu Val
340 345 350Ser Ala Ile Ser Ile Pro Ile Ser Ile Met Gly Thr Phe Ala Leu Ile
355 360 365Gln Trp Met Gly Phe Ser Leu Asn Met Leu Thr Met Val Ala Leu Thr
370 375 380Leu Ala Ile Gly Ile Ile Ile Asp Asp Ala Ile Val Val Ile Glu Asn385 390 395 400Ile His Lys Lys Leu Glu Met Gly Met Ser Lys Arg Lys Ala Ser Tyr
405 410 415Glu Gly Val Arg Glu Ile Gly Phe Ala Leu Val Ala Ile Ser Ala Met
420 425 430Leu Leu Ser Val Phe Val Pro Ile Gly Asn Met Lys Gly Ile Ile Gly
435 440 445Arg Phe Phe Gln Ser Phe Gly Ile Thr Val Ala Leu Ala Ile Ala Leu
450 455460Ser Tyr Val Val Val Val Thr Ile Ile Pro Met Val Ser Ser Val Val465 470 475 480Val Asn Pro Arg His Ser Arg Phe Tyr Val Trp Ser Glu Pro Phe Phe
485 490 495Lys Ala Leu Glu Ser Arg Tyr Thr Lys Leu Leu Gln Trp Val Leu Asn
500 505 510His Lys Ile Ile Ile Ser Ile Ala Val Val Leu Val Phe Val Gly Ser
515 520 525Leu Phe Val Ala Ser Lys Ile Gly Met Glu Phe Met Leu Lys Glu Asp
530 535 540Arg Gly Arg Phe Leu Val Trp Leu Lys Ala Lys Pro Gly Val Ser Ile545 550 555 560Asp Tyr Met Thr Gln Lys Ser Lys Ile Phe Gln Lys Ala Ile Glu Lys
565 570 575His Ala Glu Val Glu Phe Thr Thr Leu Gln Val Gly Tyr Gly Thr Thr
580 585 590Gln Asn Pro Phe Lys Ala Lys Ile Phe Val Gln Leu Lys Pro Leu Lys
595 600 605Glu Arg Lys Lys Glu His Gln Leu Gly Gln Phe Glu Leu Met Ser Val
610 615 620Leu Arg Lys Glu Leu Arg Ser Leu Pro Glu Ala Lys Gly Leu Asp Thr625 630 635 640Ile Asn Leu Ser Glu Val Thr Leu Ile Gly Gly Gly Gly Asp Ser Ser
645 650 655Pro Phe Gln Thr Phe Val Phe Ser His Ser Gln Glu Ala Val Asp Lys
660 665 670Ser Val Glu Asn Leu Lys Lys Phe Leu Leu Glu Ser Pro Glu Leu Lys
675 680685Gly Lys Val Glu Ser Tyr His Thr Ser Thr Ser Glu Ser Gln Pro Gln
690 695 700Leu Gln Leu Lys Ile Leu Arg Gln Asn Ala Asn Lys Tyr Gly Val Ser705 710 715 720Ala Gln Thr Ile Gly Ser Val Val Ser Ser Ala Phe Ser Gly Thr Ser
725 730 735Gln Ala Ser Val Phe Lys Glu Asp Gly Lys Glu Tyr Asp Met Ile Leu
740 745 750Glu Cys Leu Met Thr Ser Ala Phe Leu
755 760
(2) Sequence 381 data:
(i) sequence characteristics:
(A) length: 6025bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...5972
(D) Other information:
(xi) Description of the sequence: sequence 381: TTACACGCTT TTAAGCGGAA ATAGTATCAA ATACAATAAC CAAGCTTTAG CGG GAC 56
Arg Asp
1AAT GCT TTT TCA AAA AAT TTA TGG AAT TTA ATC CAT TAT GGT GGC GAA 104Asn Ala Phe Ser Lys Asn Leu Trp Asn Leu Ile His Tyr Gly Gly Glu
5 10 15CAA GGG ACT CTA TTA AGA GCG GAT AAC AAC ACC TTT TTTGTG CAA TTC 152Gln Gly Thr Leu Leu Arg Ala Asp Asn Asn Thr Phe Phe Val Gln Phe
20 25 30ACC CAA AGC AAC GGC CAA AAA TTT GTT TTT GAA GAA ACT TTT AAT CCG 200Thr Gln Ser Asn Gly Gln Lys Phe Val Phe Glu Glu Thr Phe Asn Pro35 40 45 50GGC TCT ATC ACC TAT AAA TAT TTC ACT ATC CAT TCT TCG CTT TTC CAC 248Gly Ser Ile Thr Tyr Lys Tyr Phe Thr Ile His Ser Ser Leu Phe His
55 60 65ACA GAC GCT GAT TCT AAG GAT ATT TGG AGT CAA GTG AGG AAG CAA TTT 296Thr Asp Ala Asp Ser Lys Asp Ile Trp Ser Gln Val Arg Lys Gln Phe
70 75 80GAT TTC ATT CCA GGA AAA ACC CCT GTG TGT GTT GGC GTG TGC TAT ATC 344Asp Phe Ile Pro Gly Lys Thr Pro Val Cys Val Gly Val Cys Tyr Ile
85 90 95GCG CCT TAT AAA AAT CAA GAC CTT ATT GGC TCT AGC GCT TTT GCG TGG 392Ala Pro Tyr Lys Asn Gln Asp Leu Ile Gly Ser Ser Ala Phe Ala Trp
100 105 110TCG CTG AAC TTT GGG GCC ACG GTG GTA GGG ACT TTG CTT TTA GGG AGC 440Ser Leu Asn Phe Gly Ala Thr Val Val Gly Thr Leu Leu Leu Gly Ser115 120 125 130GCT CAA GAA AAA GCC AAT AAT AAT GGC GGA TCG ATC TGG TTT GGT AAG 488Ala Gln Glu Lys Ala Asn Asn Asn Gly Gly Ser Ile Trp Phe Gly Lys
135 140 145AAT AAT TTG CTG TAT TTG CAT GGC AAT TTC AAC GCG ACT AAT ATC TTT 536Asn Asn Leu Leu Tyr Leu His Gly Asn Phe Asn Ala Thr Asn Ile Phe
150 155 160TTA ACG AAT AAT TTT AAT GTC GGC AAC CCT AAC GCT GGC GGT GGG GCG 584Leu Thr Asn Asn Phe Asn Val Gly Asn Pro Asn Ala Gly Gly Gly Ala
165 170 175ACG ATT AAT TTT AAC GCT GAT GAA ACC TTG AAC GCT GAC GGG TTA AAT 632Thr Ile Asn Phe Asn Ala Asp Glu Thr Leu Asn Ala Asp Gly Leu Asn
180 185 190TAC ACG AAT TTC CAA ACC GTG GCT TTG GGC TTA CAA ACC AGT GCG AGC 680Tyr Thr Asn Phe Gln Thr Val Ala Leu Gly Leu Gln Thr Ser Ala Ser195 200 205 210CAG CAT TCA TGG GCG AAT TTT AAT TCC AAG CTT TCT ATG GAG ATT AAA 728Gln His Ser Trp Ala Asn Phe Asn Ser Lys Leu Ser Met Glu Ile Lys
215 220 225AAT TCT AAC TTT AGG GAT TTC ACA TGG GGA GGC TTT AAT TTT AAT TCA 776Asn Ser Asn Phe Arg Asp Phe Thr Trp Gly Gly Phe Asn Phe Asn Ser
230 235 240GGG CGT ATC ACT TTT GAA AAC ACC ACT TTT AGC GGC TGG ACC AAT ATT 824Gly Arg Ile Thr Phe Glu Asn Thr Thr Phe Ser Gly Trp Thr Asn Ile
245 250 255AAC GGA GCG ACT GAG AGC GGC TCA TCG TAT GTG AAT ATG GTT GCG AAT 872Asn Gly Ala Thr Glu Ser Gly Ser Ser Tyr Val Asn Met Val Ala Asn
260 265 270ACG GAT TTG ATA TTT TCT AAT TCC ATT TTA GGA GGG GGC ATT CGC TAT 920Thr Asp Leu Ile Phe Ser Asn Ser Ile Leu Gly Gly Gly Ile Arg Tyr275 280 285 290GAT TTG AAA GCT AAT AAC ATT ATT TTC AAT AAC TCT CAA ATG GTT ATT 968Asp Leu Lys Ala Asn Asn Ile Ile Phe Asn Asn Ser Gln Met Val Ile
295 300 305GAT GTG TCT AAG AAT GTG AAT CAG TCA TCA TTG AAT GGG AAT GTT ACT 1016Asp Val Ser Lys Asn Val Asn Gln Ser Ser Leu Asn Gly Asn Val Thr
310 315 320TTC AAT AAT TCC AGG CTT TCA GTC AAG CCC AAT GCG GCT ATT AAT ATT 1064Phe Asn Asn Ser Arg Leu Ser Val Lys Pro Asn Ala Ala Ile Asn Ile
325 330 335GGG GAT AGC CAA ACC CAA ACG GCT TTA GAA AAC GCT TCA AGC CTT TCT 1112Gly Asp Ser Gln Thr Gln Thr Ala Leu Glu Asn Ala Ser Ser Leu Ser
340 345 350TTT TAC AAC AAC AGC GTG GCG AAT TTT AAC GGC ACA ACC GCT TTT AAC 1160Phe Tyr Asn Asn Ser Val Ala Asn Phe Asn Gly Thr Thr Ala Phe Asn355 360 365 370GGG GTG TCT TAT TTG AAT TTG AAC CCT AAC GCT CAA GTA AGC TTC AAT 1208Gly Val Ser Tyr Leu Asn Leu Asn Pro Asn Ala Gln Val Ser Phe Asn
375 380 385CAA GTA AAT TTC AAT AAC GCT AAT GTA ACT TTT TAT GGC ATT CCT TTA 1256Gln Val Asn Phe Asn Asn Ala Asn Val Thr Phe Tyr Gly Ile Pro Leu
390 395 400TTT GGT AAA ACG CCT GAT TTT GGC AAC TCT GCA CGC CTT ATC AAT TTC 1304Phe Gly Lys Thr Pro Asp Phe Gly Asn Ser Ala Arg Leu Ile Asn Phe
405 410 415AAA GGG AAT ACG AAT TTT AAT CAA GCC ACG CTC AAT TTA AGG GCT AAA 1352Lys Gly Asn Thr Asn Phe Asn Gln Ala Thr Leu Asn Leu Arg Ala Lys
420 425 430AAT ATC CAT ATC AAT TTC CAA GGC GTT TCT ACT TTT AAA CAA AAC TCT 1400Asn Ile His Ile Asn Phe Gln Gly Va1 Ser Thr Phe Lys Gln Asn Ser435 440 445 450ACG ATG AAT TTA GCT GAA AGT TCC CAA GCG AGC TTT AAC GCT CTT AAA 1448Thr Met Asn Leu Ala Glu Ser Ser Gln Ala Ser Phe Asn Ala Leu Lys
455 460 465GTG GAA GGG GAA ACG AAT TTC AAT CTC AAT AAC TCA AGC TTG TTG AAT 1496Val Glu Gly Glu Thr Asn Phe Asn LeuAsn Asn Ser Ser Leu Leu Asn
470 475 480TTC AAT GGC AAT AGC GTT TTC AAC GCT CCT GTG AGT TTT TAT GCT AAT 1544Phe Asn Gly Asn Ser Val Phe Asn Ala Pro Val Ser Phe Tyr Ala Asn
485 490 495CAT TCT CAA ATT TCT TTC ACT AAA TTA GCG ACT TTT AAT TCT GAC GCT 1592His Ser Gln Ile Ser Phe Thr Lys Leu Ala Thr Phe Asn Ser Asp Ala
500 505 510TCT TTT GAT TTA AGC AAC AAC AGC ACC CTG AAT TTT CAA AGC GTT CTT 1640Ser Phe Asp Leu Ser Asn Asn Ser Thr Leu Asn Phe Gln Ser Val Leu515 520 525 530TTA AAT GGT GCT CTA AAC CTT TTA GGC AAT GGC AGT AAC AAT CTA GCG 1688Leu Asn Gly Ala Leu Asn Leu Leu Gly Asn Gly Ser Asn Asn Leu Ala
535 540 545ATC AAC GCT AAA GGG AAT TTT AGT TTT GGG TCT AAA GGG ATT TTG AAT 1736Ile Asn Ala Lys Gly Asn Phe Ser Phe Gly Ser Lys Gly Ile Leu Asn
550 555 560CTG TCT TAT ATG AAT CTA TTT GGG GGG GAT AAA AAA ACT TCC GTT TAT 1784Leu Ser Tyr Met Asn Leu Phe Gly Gly Asp Lys Lys Thr Ser Val Tyr
565 570 575GAT GTG TTG CAA GCC CAA AAT ATT GAT GGC TTA ATG GGG AAT AAC GGC 1832Asp Val Leu Gln Ala Gln Asn Ile Asp Gly Leu Met Gly Asn Asn Gly
580 585 590TAT GAG AAG ATC CGT TTT TAT GGC ATA CAG ATT GAC AAG GCT GAT TAC 1880Tyr Glu Lys Ile Arg Phe Tyr Gly Ile Gln Ile Asp Lys Ala Asp Tyr595 600 605 610TCG TTT GAT AAC GGC GTT CAT TCT TGG AGA TTC ACT AAC CCG CTC AAT 1928Ser Phe Asp Asn Gly Val His Ser Trp Arg Phe Thr Asn Pro Leu Asn
615620 625ACG ACT GAA ACG ATT ACA GAA ACC TTG CAT AAC AAC CGC TTG AAA GTG 1976Thr Thr Glu Thr Ile Thr Glu Thr Leu His Asn Asn Arg Leu Lys Val
630 635 640CAG ATC TCT CAA AAC GGC GTT TCT AAT AAT AAG ATG TTC AAT CTC GCT 2024Gln Ile Ser Gln Asn Gly Val Ser Asn Asn Lys Met Phe Asn Leu Ala
645 650 655CCT AGC TTG TAT GAT TAC CAA AAA AAC CCT TAT AAT GAA ACC GAG AAT 2072Pro Ser Leu Tyr Asp Tyr Gln Lys Asn Pro Tyr Asn Glu Thr Glu Asn
660 665 670TCC TAT AAT TAC ACA AGC GAT AAG GTT GGC ACT TAT TAT TTA ACG AGC 2120Ser Tyr Asn Tyr Thr Ser Asp Lys Val Gly Thr Tyr Tyr Leu Thr Ser675 680 685 690AAT ATC AAA GGC TTT AAT CAA AAC AAT AAA ACA CCC GGG ACT TAT AAC 2168Asn Ile Lys Gly Phe Asn Gln Asn Asn Lys Thr Pro Gly Thr Tyr Asn
695 700 705GCG CAA AAC CAA CCC TTA CAA GCC TTA CAC ATT TAC AAT CAG GCT ATC 2216Ala Gln Asn Gln Pro Leu Gln Ala Leu His Ile Tyr Asn Gln Ala Ile
710 715 720ACT AAG CAA GAT TTG AAC ATG ATC GCC AGT TTG GGT AAG GAG TTT TTG 2264Thr Lys Gln Asp Leu Asn Met Ile Ala Ser Leu Gly Lys Glu Phe Leu
725 730 735CCT AAA ATA GCC AAT CTT TTA TCT TCA GGG GCT TTG GAT AAT CTC AAT 2312Pro Lys Ile Ala Asn Leu Leu Ser Ser Gly Ala Leu Asp Asn Leu Asn
740 745 750AGC CCG AAT AGT TTT GAA ACT CTT TTT GGT ATC TTT GAA AAG TAT GGT 2360Ser Pro Asn Ser Phe Glu Thr Leu Phe Gly Ile Phe Glu Lys Tyr Gly755 760 765 770ATC ACT TTA AAC CAA GAA AAT TGG AAG AGC TTA TTA AAG ATTATC AAT 2408Ile Thr Leu Asn Gln Glu Asn Trp Lys Ser Leu Leu Lys Ile Ile Asn
775 780 785AAT TTT TCC AAC ACA ACT AAT TAT GAT TTC TCT CAA GGC AAT CTC GTT 2456Asn Phe Ser Asn Thr Thr Asn Tyr Asp Phe Ser Gln Gly Asn Leu Val
790 795 800GTA GGA GCG ATC AAA GAG GGG CAA ACG AAC ACT AAA AGC GTG GTG TGG 2504Val Gly Ala Ile Lys Glu Gly Gln Thr Asn Thr Lys Ser Val Val Trp
805 810 815TTT GGA GGC GAA GGC TAT AAA GAG CCA TGT GCG GTT GGG GAT AAC ACT 2552Phe Gly Gly Glu Gly Tyr Lys Glu Pro Cys Ala Val Gly Asp Asn Thr
820 825 830TGC CAG ATG TTC AGA CAG ACT AAT TTA GGG CAA TTG CTC CAT TCT AGT 2600Cys Gln Met Phe Arg Gln Thr Asn Leu Gly Gln Leu Leu His Ser Ser835 840 845 850ACG CCT TAT TTA GGC TAC ATT AAC GCT AAT TTT AGG GCT AAA AAC ATT 2648Thr Pro Tyr Leu Gly Tyr Ile Asn Ala Asn Phe Arg Ala Lys Asn Ile
855 860 865TAC ATT ACC GGA ACC ATC GGC AGC GGG AAC GCT TGG GGG AGT GGA GGG 2696Tyr Ile Thr Gly Thr Ile Gly Ser Gly Asn Ala Trp Gly Ser Gly Gly
870 875 880AGT GCG AAT GTG TCT TTT GAA AGC GGC ACT AAT TTA GTG CTT AAT CAA 2744Ser Ala Asn Val Ser Phe Glu Ser Gly Thr Asn Leu Val Leu Asn Gln
885 890 895GCT AAG ATT GAC GCT CAA GGG ACC GAT AAA ATC TTT TCT TAC TTG GGG 2792Ala Lys Ile Asp Ala Gln Gly Thr Asp Lys Ile Phe Ser Tyr Leu Gly
900 905 910CAA GGG GGT ATT GAA AAG CTT TTT GGA GAA AAA GGT TTA GGG AAT GCG 2840Gln Gly Gly Ile Glu Lys Leu Phe Gly Glu Lys Gly Leu Gly Asn Ala915 920 925 930CTT TCT AAT ATC ATT TAT GAA GAG AGC TTG AAT GAT AAC GCT ATC CCT 2888Leu Ser Asn Ile Ile Tyr Glu Glu Ser Leu Asn Asp Asn Ala Ile Pro
935 940 945AAA GAT TTA GCC AAC ATG ATC CCT AAA GAT TTT GGA TCT AAG ACT TTA 2936Lys Asp Leu Ala Asn Met Ile Pro Lys Asp Phe Gly Ser Lys Thr Leu
950 955 960AGC TCA TTG CTT AGC CCT ACT GAA GTG AAT AAC CTC TTA GGC GTG AGC 2984Ser Ser Leu Leu Ser Pro Thr Glu Val Asn Asn Leu Leu Gly Val Ser
965 970 975GCA TTC AAA AAC GCG ATC ATG GAA ATT TTA AAT TCT AAA ACG GTG GGC 3032Ala Phe Lys Asn Ala Ile Met Glu Ile Leu Asn Ser Lys Thr Val Gly
980 985 990GAT GTT TTT GGT GAA AAC GGG CTT TTA AAC GCG CTA GAT CCT ACG GAA 3080Asp Val Phe Gly Glu Asn Gly Leu Leu Asn Ala Leu Asp Pro Thr Glu995 1000 1005 1010AGA AAA AAA ATT GAT CAA ATG CTT TTA GAG CAA ATC CAA GCC CAT TCT 3128Arg Lys Lys Ile Asp Gln Met Leu Leu Glu Gln Ile Gln Ala His Ser
1015 1020 1025TCA GGG TTT GAA AAA TTC ATC GTG AAA ACT TTA GGG ATT GAA AAT GTA 3176 Ser Gly Phe Glu Lys Phe Ile Val Lys Thr Leu Gly Ile Glu Asn Val
1030 1035 1040 GAG AAT TTC ATC AAT AAC TGG TAT GGC AAG CAA AGC TTG AGT TCT TTT 3224 Glu Asn Phe Ile Asn Asn Trp Tyr Gly Lys Gln Ser Leu Ser Ser Phe
1045 1050 1055 GCC AAT AAT TTT GTG CCT GGA GGC TTG AAT CAA GCC CTT GAT AAA ATA 3272 Ala Asn Asn Phe Val Pro Gly Gly Leu Asn Gln Ala Leu Asp Lys Ile
10601065 1070 GGC TCT AGC TCT GAT GCC AAA GAC TTA CAG AAC TTC TTG GAT AAA ACG 3320 Gly Ser Ser Ser Asp Ala Lys Asp Leu Gln Asn Phe Leu Asp Lys Thr 1075 1080 1085 1090 ACT TTT GGG GAT ATT TTA AAT CAA ATG ATT GAA CAA GCC CCC TTA ATC 3368 Thr Phe Gly Asp Ile Leu Asn Gln Met Ile Glu Gln Ala Pro Leu Ile
1095 ll00 1105 AAT AAA CTC ATT TCT TGG CTG GGT CCG CAG GAT TTG AGC GTT TTA GTG 3416 Asn Lys Leu Ile Ser Trp Leu Gly Pro Gln Asp Leu Ser Val Leu Val
1110 1115 1120 AAT ATC GCT TTA AAT AGC ATC ACT AAC CCT AGT AAA GAG CTG ACT AGC 3464 Asn Ile Ala Leu Asn Ser Ile Thr Asn Pro Ser Lys Glu Leu Thr Ser
1125 1130 1135 ACC ATT TCT AGC ATA GGT GAA AAA GCG TTA AAT GAC TTA TTA GGC GAT 3512 Thr Ile Ser Ser Ile Gly Glu Lys Ala Leu Asn Asp Leu Leu Gly Asp
1140 1145 1150 GGC GTA GTG AAT AAA ATC ATG AGC AAT CAA GTC TTA GGG CAA ATG ATC 3560 Gly Val Val Asn Lys Ile Met Ser Asn Gln Val Leu Gly Gln Met Ile1155 1160 1165 1170 AAT AAA ATC ATT GCT GAT AAG GGC TTT GGA GGC GTT TAT CAG CAA GGT 3608 Asn Lys Ile Ile Ala Asp Lys Gly Phe Gly Gly Val Tyr Gln Gln Gly
1175 1180 1185 TTA GGC TCC ATA CTG CCT CAA TCT TTA CAA GAT GAA TTG AAG AAA TTG 3656 Leu Gly Ser Ile Leu Pro Gln Ser Leu Gln Asp Glu Leu Lys Lys Leu
1190 1195 1200GGC ATG GGC TCT TTA CTA GGA TCT AGG GGG TTG CAC AAT CTT TGG CAA 3704 Gly Met Gly Ser Leu Leu Gly Ser Arg Gly Leu His Asn Leu Trp Gln
1205 1210 1215 AGA GGG AAT TTC AAT TTT GTG GCT AAA GAT TAT TTA TTC ACT AAT AAC 3752 Arg Gly Asn Phe Asn Phe Val Ala Lys Asp Tyr Leu Phe Thr Asn Asn
1220 1225 1230 AGC TCG TTT AGT AAC GCC ACA GGG GGG GAA TTG AAT TTT GTG GCG GGC 3800 Ser Ser Phe Ser Asn Ala Thr Gly Gly Glu Leu Asn Phe Val Ala Gly1235 1240 1245 1250 AAG TCT ATT ATT TTT AAC GGG AAA AAT ACG ATC AAT TTC ACG CAG TAT 3848 Lys Ser Ile Ile Phe Asn Gly Lys Asn Thr Ile Asn Phe Thr Gln Tyr
1255 1260 1265 CAG GGT AAG CTT TCG TTT ATT TCT AAA GAT TTT TCT AAC ATT TCA TTA 3896 Gln Gly Lys Leu Ser Phe Ile Ser Lys Asp Phe Ser Asn Ile Ser Leu
1270 1275 1280 GAT ACC TTA AAC GCT ACT AAC GGA TTA ACG CTT AAT GCT CCT AAA AAT 3944 Asp Thr Leu Asn Ala Thr Asn Gly Leu Thr Leu Asn Ala Pro Lys Asn
1285 1290 1295 GAC ATT AGC GTT CAA AAA GGT CAG ATT TGC GTG AAT GTT TTA AAT TGC 3992 Asp Ile Ser Val Gln Lys Gly Gln Ile Cys Val Asn Val Leu Asn Cys
1300 1305 1310 ATG GGC GAG AAA AAA GCT CAT TCT TCA AGC GCG ACA GCC CCA ACC AAT 4040 Met Gly Glu Lys Lys Ala His Ser Ser Ser Ala Thr Ala Pro Thr Asn1315 1320 1325 1330 GAA ACA CTA GAA GCG AAT GCG AAT AAT TTC GCT TTT TTA GGT GCA ATT 4088 Glu Thr Leu Glu Ala Asn Ala Asn Asn Phe Ala Phe Leu Gly Ala Ile
1335 1340 1345 AAG GCT AAT GGA TTA GTG GAT TTT TCA AAA GTT TTA CAA AAT ACT ACG 4136 Lys Ala Asn Gly Leu Val Asp Phe Ser Lys Val Leu Gln Asn Thr Thr
1350 1355 1360 ATC GGG ACT TTA GAT TTA GGG CCA AAC GCT ACT TTT AAA GCG AAT CAT 4184 Ile Gly Thr Leu AspLeu Gly Pro Asn Ala Thr Phe Lys Ala ASn His
1365 1370 1375TTG ATC GTG AAT AAC GCT TTT AAC AAT AAC TCT AAT TAC AGG GCT GAT 4232 Leu Ile Val Asn Asn Ala Phe Asn Asn Asn Ser Asn Tyr Arg Ala Asp
1380 1385 1390 ATT AGC GGT AAT CTC AAT GTG GTT AAA GGA GCG GCT CTC AGC ACG AAT 4280 Ile Ser Gly Asn Leu Asn Val Val Lys Gly Ala Ala Leu Ser Thr Asn1395 1400 1405 1410 GAA AAT GGT TTG AAT GTG GGG GGC GAT TTC AAG AGC GAA GGG TCA TTA 4328 Glu Asn Gly Leu Asn Val Gly Gly Asp Phe Lys Ser Glu Gly Ser Leu
1415 1420 1425 ATC TTT AAT CTT AAC AAT AAA ACC AAT CAA ACG ATT ATT AAT GTG GCT 4376 Ile Phe Asn Leu Asn Asn Lys Thr Asn Gln Thr Ile Ile Asn Val Ala
1430 1435 1440 GGC AAT TCT ACG ATC ATG TCT TAT AAC AAT CAA GCT TTA ATC CAT TTT 4424 Gly Asn Ser Thr Ile Met Ser Tyr Asn Asn Gln Ala Leu Ile His Phe
1445 1450 1455 AAT ACC CAA CTC AAG CAA GGC GCT TAC ACG CTT ATT AAT GCG AAA CGC 4472 Asn Thr Gln Leu Lys Gln Gly Ala Tyr Thr Leu Ile Asn Ala Lys Arg
1460 1465 1470 ATG CTT TAT GGT TAT GAC AAT CAA ATC ATT CGT GGA GGG AGC TTG AGC 4520 Met Leu Tyr Gly Tyr Asp Asn Gln Ile Ile Arg Gly Gly Ser Leu Ser1475 1480 1485 1490 GAT TAC CTC AAG CTT TAC ACC CTC ATT GAT TTT AAC GGC AAA CGC ATG 4568 Asp Tyr Leu Lys Leu Tyr Thr Leu Ile Asp Phe Asn Gly Lys Arg Met
1495 1500 1505 CAA TTA AAC GGC GAT TCA CTA AGC TAT GAC AAC CAA CCG GTC AAT ATT 4616 Gln Leu Asn Gly Asp Ser Leu Ser Tyr Asp Asn Gln Pro Val Asn Ile
1510 1515 1520 AAA GAT GGG GGT CTT GTG GTA AGC TTT AAA GAC AAT CAG GGG CAA ATG 4664 Lys Asp Gly Gly Leu Val Val Ser Phe Lys Asp Asn Gln Gly Gln Met
1525 1530 1535 GTG TAT TCA TCT ATC CTT TAT GAT AAA GTT CAA GTT AGC GTC TCT GAT 4712 Val Tyr Ser Ser Ile Leu Tyr Asp Lys Val Gln Val Ser Val Ser Asp
1540 1545 1550AAG CCC ATG GAT ATT CAT GCC CCT AGT TTG GAG TAT TAC ATT AAA TAC 4760 Lys Pro Met Asp Ile His Ala Pro Ser Leu Glu Tyr Tyr Ile Lys Tyr1555 1560 1565 1570 ATT CAA GGC AGT GCT GGT TTG GAT GCG ATC AAA TCT GCA GGC AAT AAT 4808 Ile Gln Gly Ser Ala Gly Leu Asp Ala Ile Lys Ser Ala Gly Asn Asn
1575 1580 1585 TCC ATT CTG TGG TTG AAT GAG CTT TTT GTG GCT AAA GGG GGT AAT CCC 4856 Ser Ile Leu Trp Leu Asn Glu Leu Phe Val Ala Lys Gly Gly Asn Pro
1590 1595 1600 TTG TTC GCT CCT TAT TAT TTG CAA GAC AAT CCC ACT GAA CAC ATT GTT 4904 Leu Phe Ala Pro Tyr Tyr Leu Gln Asp Asn Pro Thr Glu His Ile Val
1605 1610 1615 ACT TTA ATG AAA GAT ATT ACT AGC GCT TTA GGC ATG CTT TCT AAA CCC 4952 Thr Leu Met Lys Asp Ile Thr Ser Ala Leu Gly Met Leu Ser Lys Pro
1620 1625 1630 AAT CTT AAA AAC AAT TCC ACC GAT GCT TTA CAG CTC AAC ACT TAC ACG 5000 Asn Leu Lys Asn Asn Ser Thr Asp Ala Leu Gln Leu Asn Thr Tyr Thr 1635 1640 1645 1650 CAA CAA ATG AGC CGT TTA GCC AAG CTT TCT AAT TTC GCT TCC TTT GAT 5048 Gln Gln Met Ser Arg Leu Ala Lys Leu Ser Asn Phe Ala Ser Phe Asp
1655 1660 1665 TCA ACG GAT TTT AGC GAA CGC TTG AGC AGT CTT AAA AAC CAA AGA TTT 5096 Ser Thr Asp Phe Ser Glu Arg Leu Ser Ser Leu Lys Asn Gln Arg Phe
1670 1675 1680 GCT GAT GCA ATC CCT AAT GCG ATG GAT GTG ATT TTA AAA TAC TCT CAA 5144 Ala Asp Ala Ile Pro Asn Ala Met Asp Val Ile Leu Lys Tyr Ser Gln
1685 1690 1695 AGG GAT AAA CTA AAA AAC AAC CTT TGG GCG ACC GGC GTT GGG GGC GTG 5192 Arg Asp Lys Leu Lys Asn Asn Leu Trp Ala Thr Gly Val Gly Gly Val
1700 1705 1710 AGC TTT GTG GAA AAT GGC ACA GGA ACG CTC TAT GGT GTC AAT GTG GGC 5240 Ser Phe Val Glu Asn Gly Thr Gly Thr Leu Tyr Gly Val Asn Val Gly1715 1720 1725 1730TAT GAC AGA TTC ATT AAG GGT GTG ATT GTT GGA GGG TAT GCG GCT TAT 5288 Tyr Asp Arg Phe Ile Lys Gly Val Ile Val Gly Gly Tyr Ala Ala Tyr
1735 1740 1745 GGG TAT AGC GGT TTT TAT GAA CGC ATC ACT AAT TCT AAA TCC GAT AAT 5336 Gly Tyr Ser Gly Phe Tyr Glu Arg Ile Thr Asn Ser Lys Ser Asp Asn
1750 1755 1760 GTG GAT GTG GGC TTG TAT GCG AGG GCT TTC ATT AAA AAG AGC GAG CTA 5384 Val Asp Val Gly Leu Tyr Ala Arg Ala Phe Ile Lys Lys Ser Glu Leu
1765 1770 1775 ACC TTT AGC GTC AAT GAA ACT TGG GGG GCT AAT AAA AAC CAA ATC AGC 5432 Thr Phe Ser Val Asn Glu Thr Trp Gly Ala Asn Lys Asn Gln Ile Ser
1780 1785 1790 TCC AAC GAC ACT CTG CTT TCT ATG ATC AAT CAG TCC TAT AAA TAC AGC 5480 Ser Asn Asp Thr Leu Leu Ser Met Ile Asn Gln Ser Tyr Lys Tyr Ser1795 1800 1805 1810 ACA TGG ACG ACG AAC GCA AAA GTT AAT TACGGG TAT GAT TTC ATG TTT 5528 Thr Trp Thr Thr Asn Ala Lys Val Asn Tyr Gly Tyr Asp Phe Met Phe
1815 1820 1825 AAA AAC AAA AGC ATC ATT TTA AAA CCT CAA ATT GGT TTA AGG TAT TAC 5576 Lys Asn Lys Ser Ile Ile Leu Lys Pro Gln Ile Gly Leu Arg Tyr Tyr
1830 1835 1840 TAT ATC GGC ATG ACC GGT TTA GAA GGG GTG ATG CAT AAT GCG CTC TAT 5624 Tyr Ile Gly Met Thr Gly Leu Glu Gly Val Met His Asn Ala Leu Tyr
1845 1850 1855 AAC CAG TTT AAA GCG AAC GCC GAT CCG TCT AAA AAA TCC GTT TTA ACG 5672 Asn Gln Phe Lys Ala Asn Ala Asp Pro Ser Lys Lys Ser Val Leu Thr
1860 1865 1870 ATT GAA CTT GCT TTG GAG AAC CGC CAT TAT TTC AAC ACA AAC TCT TAT 5720 Ile Glu Leu Ala Leu Glu Asn Arg His Tyr Phe Asn Thr Asn Ser Tyr 1875 1880 1885 1890 TTT TAT GCG ATT GGC GGC TTT GGT AGA GAC TTA TTA GTT AAT TCT ATG 5768 Phe Tyr Ala Ile Gly Gly Phe Gly Arg Asp Leu Leu Val Asn Ser Met
1895 1900 1905GGG GAT AAA TTG GTG CGT TTT ATT GGT AAC AAC ACT TTG AGC TAC AGG 5816 Gly Asp Lys Leu Val Arg Phe Ile Gly Asn Agn Thr Leu Ser Tyr Arg
1910 1915 1920 AAA GGC GAG CTT TAT AAC ACT TTT GCG AGC ATC ACT ACA GGC GGG GAA 5864 Lys Gly Glu Leu Tyr Asn Thr Phe Ala Ser Ile Thr Thr Gly Gly Glu
1925 1930 1935 GTG AGG TTG TTT AAA AGC TTT TAT GCG AAT GCT GGG GTG GGG GCT AGG 5912 Val Arg Leu Phe Lys Ser Phe Tyr Ala Asn Ala Gly Val Gly Ala Arg
1940 1945 1950 TTT GGA TTG GAC TAT AAA ATG ATC AAC ATT ACC GGA AAT ATT GGA ATG 5960 Phe Gly Leu Asp Tyr Lys Met Ile Asn Ile Thr Gly Asn Ile Gly Met 1955 1960 1965 1970 CGT TTA GCG TTT TAAAAGGTGG GGGCTTACCC CTTTTTTGAG CCATTAAATA AATCA 6017 Arg Leu Ala Phe
1 ATGGTGGG 6025
(2) Sequence 382 data:
(i) sequence characteristics:
(A) length: 1974 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 382: arg Asp Asn Ala Phe Ser Lys Asn Leu Trp Asn Leu Ile His Tyr Gly 151015 Gly Glu Gln Gly Thr Leu Leu Arg Ala Asp Asn Asn Thr Phe Phe Val
20 25 30Gln Phe Thr Gln Ser Asn Gly Gln Lys Phe Val Phe Glu Glu Thr Phe
35 40 45Asn Pro Gly Ser Ile Thr Tyr Lys Tyr Phe Thr Ile His Ser Ser Leu
50 55 60Phe His Thr Asp Ala Asp Ser Lys Asp Ile Trp Ser Gln ValArg Lys65 70 75 80Gln Phe Asp Phe Ile Pro Gly Lys Thr Pro Val Cys Val Gly Val Cys
85 90 95Tyr Ile Ala Pro Tyr Lys Asn Gln Asp Leu Ile Gly Ser Ser Ala Phe
100 105 110Ala Trp Ser Leu Asn Phe Gly Ala Thr Val Val Gly Thr Leu Leu Leu
115 120125Gly Ser Ala Gln Glu Lys Ala Asn Asn Asn Gly Gly Ser Ile Trp Phe
130 135 140Gly Lys Asn Asn Leu Leu Tyr Leu His Gly Asn Phe Asn Ala Thr Asn145 150 155 160Ile Phe Leu Thr Asn Asn Phe Asn Val Gly Asn Pro Asn Ala Gly Gly
165 170 175Gly Ala Thr Ile Asn Phe Asn Ala Asp Glu Thr Leu Asn Ala Asp Gly
180 185 190Leu Asn Tyr Thr Asn Phe Gln Thr Val Ala Leu Gly Leu Gln Thr Ser
195 200 205Ala Ser Gln His Ser Trp Ala Asn Phe Asn Ser Lys Leu Ser Met Glu
210 215 220Ile Lys Asn Ser Asn Phe Arg Asp Phe Thr Trp Gly Gly Phe Asn Phe225 230 235 240Asn Ser Gly Arg Ile Thr Phe Glu Asn Thr Thr Phe Ser Gly Trp Thr
245 250 255Asn Ile Asn Gly Ala Thr Glu Ser Gly Ser Ser Tyr Val Asn Met Val
260 265 270Ala Asn Thr Asp Leu Ile Phe Ser Asn Ser Ile Leu Gly Gly Gly Ile
275 280 285Arg Tyr Asp Leu Lys Ala Asn Asn Ile Ile Phe Asn Asn Ser Gln Met
290 295 300Val Ile Asp Val Ser Lys Asn Val Asn Gln Ser Ser Leu Asn Gly Asn305 310 315 320Val Thr Phe Asn Asn Ser Arg Leu Ser Val Lys Pro Asn Ala Ala Ile
325 330 335Asn Ile Gly Asp Ser Gln Thr Gln Thr Ala Leu Glu Asn Ala Ser Ser
340 345 350Leu Ser Phe Tyr Asn Asn Ser Val Ala Asn Phe Asn Gly Thr Thr Ala
355 360 365Phe Asn Gly Val Ser Tyr Leu Asn Leu Asn Pro Asn Ala Gln Val Ser
370 375 380Phe Asn Gln Val Asn Phe Asn Asn Ala Asn Val Thr Phe Tyr Gly Ile385 390 395 400Pro Leu Phe Gly Lys Thr Pro Asp Phe Gly Asn Ser Ala Arg Leu Ile
405 410 415Asn Phe Lys Gly Asn Thr Asn Phe Asn Gln Ala Thr Leu Asn Leu Arg
420 425 430Ala Lys Asn Ile His Ile Asn Phe Gln Gly Val Ser Thr Phe Lys Gln
435 440 445Asn Ser Thr Met Asn Leu Ala Glu Ser Ser Gln Ala Ser Phe Asn Ala
450 455 460Leu Lys Val Glu Gly Glu Thr Asn Phe Asn Leu Asn Asn Ser Ser Leu465 470 475 480Leu Asn Phe Asn Gly Asn Ser Val Phe Asn Ala Pro Val Ser Phe Tyr
485 490 495Ala Asn His Ser Gln Ile Ser Phe Thr Lys Leu Ala Thr Phe Asn Ser
500 505 510Asp Ala Ser Phe Asp Leu Ser Asn Asn Ser Thr Leu Asn Phe Gln Ser
515 520 525Val Leu Leu Asn Gly Ala Leu Asn Leu Leu Gly Asn Gly Ser Asn Asn
530 535 540Leu Ala Ile Asn Ala Lys Gly Asn Phe Ser Phe Gly Ser Lys Gly Ile545 550 555 560Leu Asn Leu Ser Tyr Met Asn Leu Phe Gly Gly Asp Lys Lys Thr Ser
565 570575Val Tyr Asp Val Leu Gln Ala Gln Asn Ile Asp Gly Leu Met Gly Asn
580 585 590Asn Gly Tyr Glu Lys Ile Arg Phe Tyr Gly Ile Gln Ile Asp Lys Ala
595 600 605Asp Tyr Ser Phe Asp Asn Gly Val His Ser Trp Arg Phe Thr Asn Pro
610 615 620Leu Asn Thr Thr Glu Thr Ile Thr Glu Thr Leu His Asn Asn Arg Leu625 630 635 640Lys Val Gln Ile Ser Gln Asn Gly Val Ser Asn Asn Lys Met Phe Asn
645 650 655Leu Ala Pro Ser Leu Tyr Asp Tyr Gln Lys Asn Pro Tyr Asn Glu Thr
660 665 670Glu Asn Ser Tyr Asn Tyr Thr Ser Asp Lys Val Gly Thr Tyr Tyr Leu
675 680 685Thr Ser Asn Ile Lys Gly Phe Asn Gln Asn Asn Lys Thr Pro Gly Thr
690 695 700Tyr Asn Ala Gln Asn Gln Pro Leu Gln Ala Leu His Ile Tyr Asn Gln705 710 715 720Ala Ile Thr Lys Gln Asp Leu Asn Met Ile Ala Ser Leu Gly Lys Glu
725 730 735Phe Leu Pro Lys Ile Ala Asn Leu Leu Ser Ser Gly Ala Leu Asp Asn
740 745 750Leu Asn Ser Pro Asn Ser Phe Glu Thr Leu Phe Gly Ile Phe Glu Lys
755 760 765Tyr Gly Ile Thr Leu Asn Gln Glu Asn Trp Lys Ser Leu Leu Lys Ile
770 775 780Ile Asn Asn Phe Ser Asn Thr Thr Asn Tyr Asp Phe Ser Gln Gly Asn785 790 795800Leu Val Val Gly Ala Ile Lys Glu Gly Gln Thr Asn Thr Lys Ser Val
805 810 815Val Trp Phe Gly Gly Glu Gly Tyr Lys Glu Pro Cys Ala Val Gly Asp
820 825 830Asn Thr Cys Gln Met Phe Arg Gln Thr Asn Leu Gly Gln Leu Leu His
835 840 845Ser Ser Thr Pro Tyr Leu Gly Tyr Ile Asn Ala Asn Phe Arg Ala Lys
850 855 860Asn Ile Tyr Ile Thr Gly Thr Ile Gly Ser Gly Asn Ala Trp Gly Ser865 870 875 880Gly Gly Ser Ala Asn Val Ser Phe Glu Ser Gly Thr Asn Leu Val Leu
885 890 895Asn Gln Ala Lys Ile Asp Ala Gln Gly Thr Asp Lys Ile Phe Ser Tyr
900 905 910Leu Gly Gln Gly Gly Ile Glu Lys Leu Phe Gly Glu Lys Gly Leu Gly
915 920 925Asn Ala Leu Ser Asn Ile Ile Tyr Glu Glu Ser Leu Asn Asp Asn Ala
930 935 940Ile Pro Lys Asp Leu Ala Asn Met Ile Pro Lys Asp Phe Gly Ser Lys945 950 955 960Thr Leu Ser Ser Leu Leu Ser Pro Thr Glu Val Asn Asn Leu Leu Gly
965 970 975Val Ser Ala Phe Lys Asn Ala Ile Met Glu Ile Leu Asn Ser Lys Thr
980 985 990Val Gly Asp Val Phe Gly Glu Asn Gly Leu Leu Asn Ala Leu Asp Pro
995 1000 1005Thr Glu Arg Lys Lys Ile Asp Gln Met Leu Leu Glu Gln Ile Gln Ala 1010 1015 1020His Ser SerGly Phe Glu Lys Phe Ile Val Lys Thr Leu Gly Ile Glu025 1030 1035 1040Asn Val Glu Asn Phe Ile Asn Asn Trp Tyr Gly Lys Gln Ser Leu Ser
1045 1050 1055Ser Phe Ala Asn Asn Phe Val Pro Gly Gly Leu Asn Gln Ala Leu Asp
1060 1065 1070Lys Ile Gly Ser Ser Ser Asp Ala Lys Asp Leu Gln Asn Phe Leu Asp
1075 1080 1085Lys Thr Thr Phe Gly Asp Ile Leu Asn Gln Met Ile Glu Gln Ala Pro 1090 1095 1100Leu Ile Asn Lys Leu Ile Ser Trp Leu Gly Pro Gln Asp Leu Ser Val105 1110 1115 1120Leu Val Asn Ile Ala Leu Asn Ser Ile Thr Asn Pro Ser Lys Glu Leu
1125 1130 1135Thr Ser Thr Ile Ser Ser Ile Gly Glu Lys Ala Leu Asn Asp Leu Leu
1140 1145 1150Gly Asp Gly Val Val Asn Lys Ile Met Ser Asn Gln Val Leu Gly Gln
1155 1160 1165Met Ile Asn Lys Ile Ile Ala Asp Lys Gly Phe Gly Gly Val Tyr Gln 1170 1175 1180Gln Gly Leu Gly Ser Ile Leu Pro Gln Ser Leu Gln Asp Glu Leu Lys185 1190 1195 1200Lys Leu Gly Met Gly Ser Leu Leu Gly Ser Arg Gly Leu His Asn Leu
1205 1210 1215Trp Gln Arg Gly Asn Phe Asn Phe Val Ala Lys Asp Tyr Leu Phe Thr
1220 1225 1230Asn Asn Ser Ser Phe Ser Asn Ala Thr Gly Gly Glu Leu Asn Phe Val
1235 1240 1245Ala Gly Lys Ser Ile Ile Phe Asn Gly Lys Asn Thr Ile Asn Phe Thr 1250 1255 1260Gln Tyr Gln Gly Lys Leu Ser Phe Ile Ser Lys Asp Phe Ser Asn Ile265 1270 1275 1280Ser Leu Asp Thr Leu Asn Ala Thr Asn Gly Leu Thr Leu Asn Ala Pro
1285 1290 1295Lys Asn Asp Ile Ser Val Gln Lys Gly Gln Ile Cys Val Asn Val Leu
1300 1305 1310Asn Cys Met Gly Glu Lys Lys Ala His Ser Ser Ser Ala Thr Ala Pro
1315 1320 1325Thr Asn Glu Thr Leu Glu Ala Asn Ala Asn Asn Phe Ala Phe Leu Gly 1330 1335 1340Ala Ile Lys Ala Asn Gly Leu Val Asp Phe Ser Lys Val Leu Gln Asn345 1350 1355 1360Thr Thr Ile Gly Thr Leu Asp Leu Gly Pro Asn Ala Thr Phe Lys Ala
1365 1370 1375Asn His Leu Ile Val Asn Asn Ala Phe Asn Asn Asn Ser Asn Tyr Arg
1380 1385 1390Ala Asp Ile Ser Gly Asn Leu Asn Val Val Lys Gly Ala Ala Leu Ser
1395 1400 1405Thr Asn Glu Asn Gly Leu Asn Val Gly Gly Asp Phe Lys Ser Glu Gly 1410 1415 1420Ser Leu Ile Phe Asn Leu Asn Asn Lys Thr Asn Gln Thr Ile Ile Asn425 1430 1435 1440Val Ala Gly Asn Ser Thr Ile Met Ser Tyr Asn Asn Gln Ala Leu Ile
1445 1450 1455His Phe Asn Thr Gln Leu Lys Gln Gly Ala Tyr Thr Leu Ile Asn Ala
1460 1465 1470Lys Arg Met Leu Tyr Gly Tyr Asp Asn Gln Ile Ile Arg Gly Gly Ser
1475 1480 1485Leu Ser Asp Tyr Leu Lys Leu Tyr Thr Leu Ile Asp Phe Asn Gly Lys 1490 1495 1500Arg Met Gln Leu Asn Gly Asp Ser Leu Ser Tyr Asp Asn Gln Pro Val505 1510 1515 1520Asn Ile Lys Asp Gly Gly Leu Val Val Ser Phe Lys Asp Asn Gln Gly
1525 1530 1535Gln Met Val Tyr Ser Ser Ile Leu Tyr Asp Lys Val Gln Val Ser Val
1540 1545 1550Ser Asp Lys Pro Met Asp Ile His Ala Pro Ser Leu Glu Tyr Tyr Ile
1555 1560 1565Lys Tyr Ile Gln Gly Ser Ala Gly Leu Asp Ala Ile Lys Ser Ala Gly 1570 1575 1580Asn Asn Ser Ile Leu Trp Leu Asn Glu Leu Phe Val Ala Lys Gly Gly585 1590 1595 1600Asn Pro Leu Phe Ala Pro Tyr Tyr Leu Gln Asp Asn Pro Thr Glu His
1605 1610 1615Ile Val Thr Leu Met Lys Asp Ile Thr Ser Ala Leu Gly Met Leu Ser
1620 1625 1630Lys Pro Asn Leu Lys Asn Asn Ser Thr Asp Ala Leu Gln Leu Asn Thr
1635 1640 1645Tyr Thr Gln Gln Met Ser Arg Leu Ala Lys Leu Ser Asn Phe Ala Ser 1650 1655 1660Phe Asp Ser Thr Asp Phe Ser Glu Arg Leu Ser Ser Leu Lys Asn Gln665 1670 1675 1680Arg Phe Ala Asp Ala Ile Pro Asn Ala Met Asp Val Ile Leu Lys Tyr
1685 1690 1695Ser Gln Arg Asp Lys Leu Lys Asn Asn Leu Trp Ala Thr Gly Val Gly
1700 1705 1710Gly Val Ser Phe Val Glu Asn Gly Thr Gly Thr Leu Tyr Gly Val Asn
17151720 1725Val Gly Tyr Asp Arg Phe Ile Lys Gly Val Ile Val Gly Gly Tyr Ala 1730 1735 1740Ala Tyr Gly Tyr Ser Gly Phe Tyr Glu Arg Ile Thr Asn Ser Lys Ser745 1750 1755 1760Asp Asn Val Asp Val Gly Leu Tyr Ala Arg Ala Phe Ile Lys Lys Ser
1765 1770 1775Glu Leu Thr Phe Ser Val Asn Glu Thr Trp Gly Ala Asn Lys Asn Gln
1780 1785 1790Ile Ser Ser Asn Asp Thr Leu Leu Ser Met Ile Asn Gln Ser Tyr Lys
1795 1800 1805Tyr Ser Thr Trp Thr Thr Asn Ala Lys Val Asn Tyr Gly Tyr Asp Phe 1810 1815 1820Met Phe Lys Asn Lys Ser Ile Ile Leu Lys Pro Gln Ile Gly Leu Arg825 1830 1835 1840Tyr Tyr Tyr Ile Gly Met Thr Gly Leu Glu Gly Val Met His Asn Ala
1845 1850 1855Leu Tyr Asn Gln Phe Lys Ala Asn Ala Asp Pro Ser Lys Lys Ser Val
1860 1865 1870Leu Thr Ile Glu Leu Ala Leu Glu Asn Arg His Tyr Phe Asn Thr Asn
1875 1880 1885Ser Tyr Phe Tyr Ala Ile Gly Gly Phe Gly Arg Asp Leu Leu Val Asn 1890 1895 1900Ser Met Gly Asp Lys Leu Val Arg Phe Ile Gly Asn Asn Thr Leu Ser905 1910 1915 1920Tyr Arg Lys Gly Glu Leu Tyr Asn Thr Phe Ala Ser Ile Thr Thr Gly
1925 1930 1935Gly Glu Val Arg Leu Phe Lys Ser Phe Tyr Ala Asn Ala Gly Val Gly
1940 1945 1950Ala Arg Phe Gly Leu Asp Tyr Lys Met Ile Asn Ile Thr Gly Asn Ile
1955 1960 1965Gly Met Arg Leu Ala Phe 1970 1
(2) Sequence 383 data:
(i) sequence characteristics:
(A) length: 755bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 124...690
(D) Other information:
(xi) Description of the sequence: sequence 383: TTGCGCTTAT AAATTCCCGG CTTTAGAAAA ACACACCAAA ATTGTAGGAG TCATTAACCA 60AGTGGGGCGC ASSGGGCGAT CACACCGGTC GCTCTTTTAG AGCCTGTGGA AATTGCTGGA 120GCT ATG ATT AAT AGA GCG ACC TTA CAC AAT TAT TCT GAA ATT GAA AAA 168
Met Ile Asn Arg Ala Thr Leu His Asn Tyr Ser Glu Ile Glu Lys
1 5 10 15AAG AAT ATC ATG CTC AGT GAT AGG GTC GTT GTC ATT AGA AGC GGC GAT 216Lys Asn Ile Met Leu Ser Asp Arg Val Val Val Ile Arg Ser Gly Asp
20 25 30GTG ATC CCT AAA ATC ATC AAG CCT TTA GAA TCT TAT AGA GAC GGC TCG 264Val Ile Pro Lys Ile Ile Lys Pro Leu Glu Ser Tyr Arg Asp Gly Ser
35 40 45CAA CAT AAA ATT GAA CGC CCC AAG GTT TGC CCT ATA TGT TCG CAT GAG 312Gln His Lys Ile Glu Arg Pro Lys Val Cys Pro Ile Cys Ser His Glu
50 55 60CTT TTG TGC GAA GAG ATT TTT ACT TATTGT CAA AAC CTT AAT TGC CCG 360Leu Leu Cys Glu Glu Ile Phe Thr Tyr Cys Gln Asn Leu Asn Cys Pro
65 70 75GCA AGG TTG AAA GAA AGC TTG ATT CAT TTC GCT TCT AAA GAC GCT TTA 408Ala Arg Leu Lys Glu Ser Leu Ile His Phe Ala Ser Lys Asp Ala Leu80 85 90 95AAC ATT CAA GGC TTG GGC GAT AAA GTC ATA GAG CAA CTT TTT GAA GAA 456Asn Ile Gln Gly Leu Gly Asp Lys Val Ile Glu Gln Leu Phe Glu Glu
100 105 110AAG CTC ATT TTT AAC GCT CTG GAT TTG TAT GCT TTA AAA TTA GAA GAT 504Lys Leu Ile Phe Asn Ala Leu Asp Leu Tyr Ala Leu Lys Leu Glu Asp
115 120 125TTA ATG CGG CTA GAC AAA TTT AAA ATT AAA AAA GCT CAA AAT CTA TTA 552Leu Met Arg Leu Asp Lys Phe Lys Ile Lys Lys Ala Gln Asn Leu Leu
130 135 140GAC GCT ATT TTA AAA AGC AAA AAC CCT CCC TTA TGG CGT TTG ATT AAC 600Asp Ala Ile Leu Lys Ser Lys Asn Pro Pro Leu Trp Arg Leu Ile Asn
145 150 155GCT TTA GGG ATT GAG CAT ATT GGT AAG GGA GCG AGT AAA ACG CTG GCC 648Ala Leu Gly Ile Glu His Ile Gly Lys Gly Ala Ser Lys Thr Leu Ala160 165 170 175AAA TAC GGC TTA AAT GTG TTA GAA AAA AGC GAA SCG AGT TTT TAGAAATGG 699Lys Tyr Gly Leu Asn Val Leu Glu Lys Ser Glu Xaa Ser Phe
180 185AAGGCTTTGG GGTGGAAATG GCGCGCTCTT TAGTCAATTTTTATGCGAGC AATCAA 755
(2) Sequence 384 data:
(i) sequence characteristics:
(A) length: 189 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 384: met Ile Asn Arg Ala Thr Leu His Asn Tyr Ser Glu Ile Glu Lys Lys 151015 Asn Ile Met Leu Ser Asp Arg Val Val Val Ile Arg Ser Gly Asp Val
20 25 30Ile Pro Lys Ile Ile Lys Pro Leu Glu Ser Tyr Arg Asp Gly Ser Gln
35 40 45His Lys Ile Glu Arg Pro Lys Val Cys Pro Ile Cys Ser His Glu Leu
50 55 60Leu Cys Glu Glu Ile Phe Thr Tyr Cys Gln Asn Leu Asn Cys Pro Ala65 70 75 80Arg Leu Lys Glu Ser Leu Ile His Phe Ala SerLys Asp Ala Leu Asn
85 90 95Ile Gln Gly Leu Gly Asp Lys Val Ile Glu Gln Leu Phe Glu Glu Lys
100 105 110Leu Ile Phe Asn Ala Leu Asp Leu Tyr Ala Leu Lys Leu Glu Asp Leu
115 120 125Met Arg Leu Asp Lys Phe Lys Ile Lys Lys Ala Gln Asn Leu Leu Asp
130 135 140Ala Ile Leu Lys Ser Lys Asn Pro Pro Leu Trp Arg Leu Ile Asn Ala145 150 155 160Leu Gly Ile Glu His Ile Gly Lys Gly Ala Ser Lys Thr Leu Ala Lys
165 170 175Tyr Gly Leu Asn Val Leu Glu Lys Ser Glu Xaa Ser Phe
180 185
(2) Sequence 385 data:
(i)sequence characteristics:
(A) length: 403 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...350
(D) Other information:
(xi) Description of the sequence: sequence 385: AAAGGGCGAT TATCAAGGGG CTTTCAAGCT TTTTTCCCAA TCGTGCGATA ATG GTA 56
Met Val
1ATG CGG CCG GGT GTT TTG CAA GTG GGG GCG ATG TAT GCT AAT GGG GTA 104Met Arg Pro Gly Val Leu Gln Val Gly Ala Met Tyr Ala Asn Gly Val
5 10 15GGG ATC CAA ACC AAC AGA TTA AAA GCC GCT CGC TAT TAT GAA TGG GTT 152Gly Ile Gln Thr Asn Arg Leu Lys Ala Ala Arg Tyr Tyr Glu Trp Val
20 25 30GCA GCG GGG GCG ATG CGA CCG CTT GCG CGA ATC TGG CTC AGA TGT ATG 200Ala Ala Gly Ala Met Arg Pro Leu Ala Arg Ile Trp Leu Arg Cys Met35 40 45 50AAA ACA AGA AAA ATG CGG ATT CAA ACG ATA AAG AAA ACG CTT TGC AAT 248Lys Thr Arg Lys Met Arg Ile Gln Thr Ile Lys Lys Thr Leu Cys Asn
55 60 65TGT ATG CGG TGG CTT GTC AAG GGG GGG ATA TGC TCG CAT GCA ATA ATT 296Cys Met Arg Trp Leu Val Lys Gly Gly Ile Cys Ser His Ala Ile Ile
70 7580TGG GGT GGA TGT TTG CTA ACG GAA GTG GGG TCC CAA AAG ATT ATT ACA 344Trp Gly Gly Cys Leu Leu Thr Glu Val Gly Ser Gln Lys Ile Ile Thr
85 90 95AAG CGA TAAGTTATTA TAAATTTTCA TGCGAGAATG GGAATGATAT GGGGTGTTAT AA 402Lys Arg
100T 403
(2) Sequence 386 data:
(i) sequence characteristics:
(A) length: 100 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 386: met Val Met Arg Pro Gly Val Leu Gln Val Gly Ala Met Tyr Ala Asn 151015 Gly Val Gly Ile Gln Thr Asn Arg Leu Lys Ala Ala Arg Tyr Tyr Glu
20 25 30Trp Val Ala Ala Gly Ala Met Arg Pro Leu Ala Arg Ile Trp Leu Arg
35 40 45Cys Met Lys Thr Arg Lys Met Arg Ile Gln Thr Ile Lys Lys Thr Leu
50 55 60Cys Asn Cys Met Arg Trp Leu Val Lys Gly Gly Ile Cys Ser His Ala65 70 75 80Ile Ile Trp Gly Gly Cys Leu Leu Thr Glu Val Gly Ser Gln Lys Ile
85 90 95Ile Thr Lys Arg
100
(2) Sequence 387 data:
(i) sequence characteristics:
(A) length: 1837bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1784
(D) Other information:
(xi) Description of the sequence: sequence 387: CGCATGCGCT CCTTTCTAAA GCGATCAAAA ACAAAGAGTA AGGGATTAAC ATG TCA 56
Met Ser
1AAA AAA ATC GTA GTC GAT CCT ATC ACT AGG ATT GAG GGG CAT TTA AGG 104Lys Lys Ile Val Val Asp Pro Ile Thr Arg Ile Glu Gly His Leu Arg
5 10 15ATT GAA GTG ATC GTA GAT GAT GAT AAC GTG ATC ACT GAT GCG TTT TCT 152Ile Glu Val Ile Val Asp Asp Asp Asn Val Ile Thr Asp Ala Phe Ser
20 25 30TCT TCT ACG CTT TTT AGG GGG CTA GAA ACC ATT ATT AAA GGC AGA GAT 200Ser Ser Thr Leu Phe Arg Gly Leu Glu Thr Ile Ile Lys Gly Arg Asp35 40 45 50CCA CGA GAT GCA GGC TTC ATC GCT CAA AGG ATT TGC GGG GTA TGC ACT 248Pro Arg Asp Ala Gly Phe Ile Ala Gln Arg Ile Cys Gly Val Cys Thr
55 60 65TAT TCG CAT TAT AAG GCC GGT ATC ACG GCG GTA GAA AAC GCT CTA GGC 296Tyr Ser His Tyr Lys Ala Gly Ile Thr Ala Val Glu Asn Ala Leu Gly
70 75 80ATC ACT CCC CCATTA AAC GCG CAA TTG GTG CGA TCT TTG ATG AAC ATG 344Ile Thr Pro Pro Leu Asn Ala Gln Leu Val Arg Ser Leu Met Asn Met
85 90 95GCG CTG CTT TTT CAT GAC CAT GTG GTG CAT TTC TAT ACT TTG CAT GGG 392Ala Leu Leu Phe His Asp His Val Val His Phe Tyr Thr Leu His Gly
100 105 110CTT GAT TGG TGC GAT ATC ATG AGC GCT TTA AAA GCC GAT CCC ATT CAA 440Leu Asp Trp Cys Asp Ile Met Ser Ala Leu Lys Ala Asp Pro Ile Gln115 120 125 130GCG GCA AAA CTT TCT TTC AAA TAC AGC CCT TAC CCT ATT AAT ACC GGT 488Ala Ala Lys Leu Ser Phe Lys Tyr Ser Pro Tyr Pro Ile Asn Thr Gly
135 140 145GCC GGT GAA TTA AAA GCG GTT CAA AAA CGC TTG AGC GAT TTC GCT AAA 536Ala Gly Glu Leu Lys Ala Val Gln Lys Arg Leu Ser Asp Phe Ala Lys
150 155 160AGC GGA TCT TTG GGG CCT TTC AGT AAC GGC TAT TAC GGG CAT AAA ACT 584Ser Gly Ser Leu Gly Pro Phe Ser Asn Gly Tyr Tyr Gly His Lys Thr
165 170 175TAT CGT TTA AGT CCG GAG CAA AAT TTA ATC GTC TTA AGC CAC TAC CTC 632Tyr Arg Leu Ser Pro Glu Gln Asn Leu Ile Val Leu Ser His Tyr Leu
180 185 190AAG CTT TTA GAA ATC CAA AGG GAA GCG GCG AAA ATG ACC GCT ATT TTT 680Lys Leu Leu Glu Ile Gln Arg Glu Ala Ala Lys Met Thr Ala Ile Phe195 200 205 210GGG GCC AAA CAG CCT CAC CCA CAA AGC CTA ACG GTG GGG GGT GTT ACG 728Gly Ala Lys Gln Pro His Pro Gln Ser Leu Thr Val Gly Gly Val Thr
215 220 225AGT GTT ATG GAT ATA TTG GAT CCG ACG AGA TTG GCT GAA TGG AAG AGC 776Ser Val Met Asp Ile Leu Asp Pro Thr Arg Leu Ala Glu Trp Lys Ser
230 235 240AAG TTT GAA GTG GTG GCC AAT TTC ATC AAC CAT GCT TAC TAC CCT GAT 824Lys Phe Glu Val Val Ala Asn Phe Ile Asn His Ala Tyr Tyr Pro Asp
245 250 255TTG GTG ATG GCA GGC GAA ATG TTC GCT AAC GAA CAA TCC GTT ATC AAA 872Leu Val Met Ala Gly Glu Met Phe Ala Asn Glu Gln Ser Val Ile Lys
260 265 270GGC TGT GGC TTA AGG AAT TTT ATC GCT TAT GAA GAA GTG CTG CTT GGG 920Gly Cys Gly Leu Arg Asn Phe Ile Ala Tyr Glu Glu Val Leu Leu Gly275 280 285 290AGG GAT AAA TAC CTT TTG AGT AGT GGG GTG GTG CTT GAT GGG GAT ATT 968Arg Asp Lys Tyr Leu Leu Ser Ser Gly Val Val Leu Asp Gly Asp Ile
295 300 305TCT AAA TTA CAC CCC ATT GAT GAA AGT TTG ATT AAA GAA GAA GTT ACG 1016Ser Lys Leu His Pro Ile Asp Glu Ser Leu Ile Lys Glu Glu Val Thr
310 315 320CAT TCT TGG TAT CAA TAC GAA GAC ACT AAA GAA GTG CAA CTC CAC CCT 1064His Ser Trp Tyr Gln Tyr Glu Asp Thr Lys Glu Val Gln Leu His Pro
325 330 335TAT GAC GGG CAA ACG AAC CCG CAT TAT ACC GGT TTA AAA GAC GGC GAG 1112Tyr Asp Gly Gln Thr Asn Pro His Tyr Thr Gly Leu Lys Asp Gly Glu
340 345 350AGC GTG GGG ATT GAA AAT AAA ATC ATC CCT GCT AAA GTG CTT GAC ACT 1160Ser Val Gly Ile Glu Asn Lys Ile Ile Pro Ala Lys Val Leu Asp Thr355 360 365 370AAA AAT AAA TAT TCT TGG ATA AAA TCG CCC AGA TAC GAT AGT AAG CCC 1208Lys Asn Lys Tyr Ser Trp Ile Lys Ser Pro Arg Tyr Asp Ser Lys Pro
375380 385ATG GAA GTA GGT CCT TTA AGT TCC GTA GTG GTA GGT TTA GCG GCG AAA 1256Met Glu Val Gly Pro Leu Ser Ser Val Val Val Gly Leu Ala Ala Lys
390 395 400AAC CCT TAT GTT ACT GAA GTG GCT ACG AAG TTT TTA AAA GAC ACT AAA 1304Asn Pro Tyr Val Thr Glu Val Ala Thr Lys Phe Leu Lys Asp Thr Lys
405 410 415CTG CCT TTA GAG GCG TTG TTT TCA ACG CTT GGG CGA ACA GCT GCA AGG 1352Leu Pro Leu Glu Ala Leu Phe Ser Thr Leu Gly Arg Thr Ala Ala Arg
420 425 430TGT ATT GAA GCT AAA ACG ATC GCT GAT AAT GGC CTT TTG GCG TTT GAT 1400Cys Ile Glu Ala Lys Thr Ile Ala Asp Asn Gly Leu Leu Ala Phe Asp435 440 445 450GCG TTA GTG GAA AAT CTA AAA AGC GAT CAA AGC ACT TGT GCT CCT TAT 1448Ala Leu Val Glu Asn Leu Lys Ser Asp Gln Ser Thr Cys Ala Pro Tyr
455 460 465CAC ATT GAT AAA AAT CAA GAA TAT AAA GGG CGC TAC ATT GGT CAA GTG 1496His Ile Asp Lys Asn Gln Glu Tyr Lys Gly Arg Tyr Ile Gly Gln Val
470 475 480CCA AGG GGC ATG CTA AGC CAT TGG GTG CGT ATT AAA AAC GGC GTG GTG 1544Pro Arg Gly Met Leu Ser His Trp Val Arg Ile Lys Asn Gly Val Val
485 490 495GAA AAT TAT CAA GCG GTG GTG CCT TCT ACT TGG AAT GCA GGG CCT AGA 1592Glu Asn Tyr Gln Ala Val Val Pro Ser Thr Trp Asn Ala Gly Pro Arg
500 505 510GAT TCT CAA AAT CAA AGG GGG GCT TAT GAA ATG AGC TTG ATT GGC ACT 1640Asp Ser Gln Asn Gln Arg Gly Ala Tyr Glu Met Ser Leu Ile Gly Thr515 520 525 530AAA ATC GCT GAT TTA ACC CAG CCT TTA GAA ATC ATT AGG ACT ATC CAT 1688Lys Ile Ala Asp Leu Thr Gln Pro Leu Glu Ile Ile Arg Thr Ile His
535 540 545TCT TTT GAC CCA TGC ATC GCA TGC TCG GTG CAT GTG ATG GAT TTT AAA 1736Ser Phe Asp Pro Cys Ile Ala Cys Ser Val His Val Met Asp Phe Lys
550 555 560GGG CAG TCT TTA AAC GAG TTT AAA GTA GAG CCT AAT TTC GCT AAA TTC T 1785Gly Gln Ser Leu Asn Glu Phe Lys Val Glu Pro Asn Phe Ala Lys Phe
565 570 575AAAAAGGGTT ACGCATGGAT AAAATGAATA AGGTCGTTTT ACACAAAGAA TA 1837
(2) Sequence 388 data:
(i) sequence characteristics:
(A) length: 578 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 388: met Ser Lys Lys Ile Val Val Asp Pro Ile Thr Arg Ile Glu Gly His 151015 Leu Arg Ile Glu Val Ile Val Asp Asp Asp Asn Val Ile Thr Asp Ala
20 25 30Phe Ser Ser Ser Thr Leu Phe Arg Gly Leu Glu Thr Ile Ile Lys Gly
35 40 45Arg Asp Pro Arg Asp Ala Gly Phe Ile Ala Gln Arg Ile Cys Gly Val
50 55 60Cys Thr Tyr Ser His Tyr Lys Ala Gly Ile Thr Ala Val Glu Asn Ala65 70 75 80Leu Gly Ile Thr Pro Pro Leu Asn Ala Gln Leu Val Arg Ser Leu Met
85 90 95Asn Met Ala Leu Leu Phe His Asp His Val Val His Phe Tyr Thr Leu
100 105 110His Gly Leu Asp Trp Cys Asp Ile Met Ser Ala Leu Lys Ala Asp Pro
115 120 125Ile Gln Ala Ala Lys Leu Ser Phe Lys Tyr Ser Pro Tyr Pro Ile Asn
130 135 140Thr Gly Ala Gly Glu Leu Lys Ala Val Gln Lys Arg Leu Ser Asp Phe145 150 155 160Ala Lys Ser Gly Ser Leu Gly Pro Phe Ser Asn Gly Tyr Tyr Gly His
165 170 175Lys Thr Tyr Arg Leu Ser Pro Glu Gln Asn Leu Ile Val Leu Ser His
180 185 190Tyr Leu Lys Leu Leu Glu Ile Gln Arg Glu Ala Ala Lys Met Thr Ala
195 200 205Ile Phe Gly Ala Lys Gln Pro His Pro Gln Ser Leu Thr Val Gly Gly
210 215 220Val Thr Ser Val Met Asp Ile Leu Asp Pro Thr Arg Leu Ala Glu Trp225 230 235 240Lys Ser Lys Phe Glu Val ValAla Asn Phe Ile Asn His Ala Tyr Tyr
245 250 255Pro Asp Leu Val Met Ala Gly Glu Met Phe Ala Asn Glu Gln Ser Val
260 265 270Ile Lys Gly Cys Gly Leu Arg Asn Phe Ile Ala Tyr Glu Glu Val Leu
275 280 285Leu Gly Arg Asp Lys Tyr Leu Leu Ser Ser Gly Val Val Leu Asp Gly
290 295 300Asp Ile Ser Lys Leu His Pro Ile Asp Glu Ser Leu Ile Lys Glu Glu305310 315 320Val Thr His Ser Trp Tyr Gln Tyr Glu Asp Thr Lys Glu Val Gln Leu
325 330 335His Pro Tyr Asp Gly Gln Thr Asn Pro His Tyr Thr Gly Leu Lys Asp
340 345 350Gly Glu Ser Val Gly Ile Glu Asn Lys Ile Ile Pro Ala Lys Val Leu
355 360 365Asp Thr Lys Asn Lys Tyr Ser Trp Ile Lys Ser Pro Arg Tyr Asp Ser
370 375 380Lys Pro Met Glu Val Gly Pro Leu Ser Ser Val Val Val Gly Leu Ala385 390 395 400Ala Lys Asn Pro Tyr Val Thr Glu Val Ala Thr Lys Phe Leu Lys Asp
405 410 415Thr Lys Leu Pro Leu Glu Ala Leu Phe Ser Thr Leu Gly Arg Thr Ala
420 425 430Ala Arg Cys Ile Glu Ala Lys Thr Ile Ala Asp Asn Gly Leu Leu Ala
435 440 445Phe Asp Ala Leu Val Glu Asn Leu Lys Ser Asp Gln Ser Thr Cys Ala
450 455 460Pro Tyr His Ile Asp Lys Asn Gln Glu Tyr Lys Gly Arg Tyr Ile Gly465 470 475 480Gln Val Pro Arg Gly Met Leu Ser His Trp Val Arg Ile Lys Asn Gly
485 490 495Val Val Glu Asn Tyr Gln Ala Val Val Pro Ser Thr Trp Asn Ala Gly
500 505 510Pro Arg Asp Ser Gln Asn Gln Arg Gly Ala Tyr Glu Met Ser Leu Ile
515 520 525Gly Thr Lys Ile Ala Asp Leu Thr Gln Pro Leu Glu Ile Ile Arg Thr
530 535 540Ile His Ser Phe Asp Pro Cys Ile Ala Cys Ser Val His Val Met Asp545 550 555 560Phe Lys Gly Gln Ser Leu Asn Glu Phe Lys Val Glu Pro Asn Phe Ala
565 570 575Lys Phe
(2) Sequence 389 data:
(i) sequence characteristics:
(A) length: 720 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 80...613
(D) Other information:
(xi) Description of the sequence: sequence 389: ATATGGTGTT TTTCCATTCT ATCAGGTATG AAAGTTCGGG GGCGGATTCT ATGATTAATG 60GCTATGGTTA TACCAAAGA ATG AGT CAA AAA ATC CTA ATT CTA GGT ATT GGC 112
Met Ser Gln Lys Ile Leu Ile Leu Gly Ile Gly
1 5 10AAT ATC CTT TTT GGC GAT GAA GGG ATT GGG GTG CAT TTA GCC CAC TAC 160Asn Ile Leu Phe Gly Asp Glu Gly Ile Gly Val His Leu Ala His Tyr
15 20 25CTC AAA AAA AAT TTT TCT TTT TTC CCT AGC GTG GAT ATT ATA GAT GGG 208Leu Lys Lys Asn Phe Ser Phe Phe Pro Ser Val Asp Ile Ile Asp Gly
30 35 40GGG ACA ATG GCC CAG CAG CTC ATT CCT TTA ATC ACT TCG TAT GAA AAG 256Gly Thr Met Ala Gln Gln Leu Ile Pro Leu Ile Thr Ser Tyr Glu Lys
45 50 55GTT TTG ATT TTG GAT TGC GTG AGC GCT GAA GGC GTT GAG ATA GGA TCA 304Val Leu Ile Leu Asp Cys Val Ser Ala Glu Gly Val Glu Ile Gly Ser60 65 70 75GTC TAT GCT TTT GAT TTT AAG GAC GCT CCT AAA GAA ATC ACA TGG GCT 352Val Tyr Ala Phe Asp Phe Lys Asp Ala Pro Lys Glu Ile Thr Trp Ala
80 85 90GGG AGC GCT CAT GAA GTG GAA ATG CTA CAC ACT TTA AGG CTC ACG GAG 400Gly Ser Ala His Glu Val Glu Met Leu His Thr Leu Arg Leu Thr Glu
95 100 105TTT TTA GGG GAT TTG CCT AAA ACT TTT ATC GTG GGG CTT GTG CCT TTT 448Phe Leu Gly Asp Leu Pro Lys Thr Phe Ile Val Gly Leu Val Pro Phe
110 115 120GTG ATA GGG AGC GAG ACC ACT TTC AAG CTT TCA AGC AAA ATT TTA AAC 496Val Ile Gly Ser Glu Thr Thr Phe Lys Leu Ser Ser Lys Ile Leu Asn
125 130 135GCT TTA GAA ACC GCC TTA AAA GCC ATA GAA ACC CAA CTC AAC GCA TGG 544Ala Leu Glu Thr Ala Leu Lys Ala Ile Glu Thr Gln Leu Asn Ala Trp140 145 150 155GGG GTT AAA ATG CAA CGC ACC GAT CAT ATC GCT TTA GAA TGT ATC GCT 592Gly Val Lys Met Gln Arg Thr Asp His Ile Ala Leu Glu Cys Ile Ala
160 165 170GAA CTT TCT TAT AAG GGT TTT TGAATTGGTT TTTGTTTTTC TTTTTAAATG CGTT 647Glu Leu Ser Tyr Lys Gly Phe
175AATGAAGAAA CAAGCCTGAA TTTTACGCCC CTTTTAGAGC GAATGGCATG CAATTTGCAA 707GCGCGTTTTT ATA 720
(2) Sequence 390 data:
(i)sequence characteristics:
(A) length: 178 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 390: met Ser Gln Lys Ile Leu Ile Leu Gly Ile Gly Asn Ile Leu Phe Gly 151015 Asp Glu Gly Ile Gly Val His Leu Ala His Tyr Leu Lys Lys Asn Phe
20 25 30Ser Phe Phe Pro Ser Val Asp Ile Ile Asp Gly Gly Thr Met Ala Gln
35 40 45Gln Leu Ile Pro Leu Ile Thr Ser Tyr Glu Lys Val Leu Ile Leu Asp
50 55 60Cys Val Ser Ala Glu Gly Val Glu Ile Gly Ser Val Tyr Ala Phe Asp65 70 75 80Phe Lys Asp Ala Pro Lys Glu Ile Thr Trp Ala Gly Ser Ala His Glu
85 90 95Val Glu Met Leu His Thr Leu Arg Leu Thr Glu Phe Leu Gly Asp Leu
100 105 110Pro Lys Thr Phe Ile Val Gly Leu Val Pro Phe Val Ile Gly Ser Glu
115 120 125Thr Thr Phe Lys Leu Ser Ser Lys Ile Leu Asn Ala Leu Glu Thr Ala
130 135 140Leu Lys Ala Ile Glu Thr Gln Leu Asn Ala Trp Gly Val Lys Met Gln145 150 155 160Arg Thr Asp His Ile Ala Leu Glu Cys Ile Ala Glu Leu Ser Tyr Lys
165 170 175Gly Phe
(2) Sequence 391 data:
(i) sequence characteristics:
(A) length: 508 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...455
(D) Other information:
(xi) Description of the sequence: sequence 391: ATTGAAGCGA GTAACGCTTA TTATAAAAAA CGCTTATAAA TCTTATCAAC ATG GGC 56
Met Gly
1AAT TTG ACT TAT TAC GCT TAC ATG TAT TTG ATC CTC TTT GTA TGC TTG 104Asn Leu Thr Tyr Tyr Ala Tyr Met Tyr Leu Ile Leu Phe Val Cys Leu
5 10 15CTG CCT GTG TTA TTA ATG GGG CTT GTT TGG AGG CTT ACT CGC CCC CCC 152Leu Pro Val Leu Leu Met Gly Leu Val Trp Arg Leu Thr Arg Pro Pro
20 25 30TTA AAG CAA AAT ATT CCT AAT AAA AGC CTC TCT TTA GAA AAT TTA AAC 200Leu Lys Gln Asn Ile Pro Asn Lys Ser Leu Ser Leu Glu Asn Leu Asn35 40 45 50GAA CAA ATC AAA AAC CTT AAA AGC GTA CCA GCT TTA GAA AAA CTG AAA 248Glu Gln Ile Lys Asn Leu Lys Ser Val Pro Ala Leu Glu Lys Leu Lys
55 60 65AAC GAC TTC AAT GAG CGT TTT AAA ATT TGC CCC AAA GAT AAA GAA ACT 296Asn Asp Phe Asn Glu Arg Phe Lys Ile CysPro Lys Asp Lys Glu Thr
70 75 80CTG TGG TTA GAA ACG ATC CAA AAA TTA GTC GCT TCA GAA TTT TTT GAA 344Leu Trp Leu Glu Thr Ile Gln Lys Leu Val Ala Ser Glu Phe Phe Glu
85 90 95TTA GAA GAC GCT ATT AAT TTT GGG CAA GAA TTA GAA AAC GCT AAC CCT 392Leu Glu Asp Ala Ile Asn Phe Gly Gln Glu Leu Glu Asn Ala Asn Pro
100 105 110AAT TAC CAA CAA AAA ATC GCT AAC GCT ACC GGC TTA GCC CTT AAG AAT 440Asn Tyr Gln Gln Lys Ile Ala Asn Ala Thr Gly Leu Ala Leu Lys Asn115 120 125 130AAA AAA GAA AAA GGA TAGAATTGGA TTTTTTAGAG ATTGTAGGAC AAGTCCCTTT A 496Lys Lys Glu Lys Gly
135AAAGGAGAGG TA 508
(2) Sequence 392 data:
(i) sequence characteristics:
(A) length: 135 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 392: met Gly Asn Leu Thr Tyr Tyr Ala Tyr Met Tyr Leu Ile Leu Phe Val 151015 Cys Leu Leu Pro Val Leu Leu Met Gly Leu Val Trp Arg Leu Thr Arg
20 25 30Pro Pro Leu Lys Gln Asn Ile Pro Asn Lys Ser Leu Ser Leu Glu Asn
35 40 45Leu Asn Glu Gln Ile Lys Asn Leu Lys Ser Val Pro Ala Leu Glu Lys
5055 60Leu Lys Asn Asp Phe Asn Glu Arg Phe Lys Ile Cys Pro Lys Asp Lys65 70 75 80Glu Thr Leu Trp Leu Glu Thr Ile Gln Lys Leu Val Ala Ser Glu Phe
85 90 95Phe Glu Leu Glu Asp Ala Ile Asn Phe Gly Gln Glu Leu Glu Asn Ala
100 105 110Asn Pro Asn Tyr Gln Gln Lys Ile Ala Asn Ala Thr Gly Leu Ala Leu
115 120 125Lys Asn Lys Lys Glu Lys Gly
130 135
(2) Data in seq id No. 393:
(i) sequence characteristics:
(A) length: 1183bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1130
(D) Other information:
(xi) Description of the sequence: sequence 393: ATCTAAAAAT GCTACAATGT TTATCTTTAA AACGAAAGGG CAATTTAACC ATG GAC 56
Met Asp
1TTT TTA GAA AAA GTA TTA GAC AAT CAA GTT ACT GAA AGT AAA GAA TTG 104Phe Leu Glu Lys Val Leu Asp Asn Gln Val Thr Glu Ser Lys Glu Leu
5 10 15GTC AGG CTT TAT GAT TAT GAT TTA TAC ACG CTA GGG GAA GTA GCG GAT 152Val Arg Leu Tyr Asp Tyr Asp Leu Tyr Thr Leu Gly Glu Val Ala Asp
20 25 30CGC ATG CGC CAA AAC ATG CAC CAA AAA ATC GTG TAT TTT AAT GTC AAT 200Arg Met Arg Gln Asn Met His Gln Lys Ile Val Tyr Phe Asn Val Asn35 40 45 50AGG CAT TTA AAC CCT AGC AAT ATT TGC GCG GAC GCT TGC AAA TTT TGC 248Arg His Leu Asn Pro Ser Asn Ile Cys Ala Asp Ala Cys Lys Phe Cys
55 60 65GCT TTT TCA GCC CAC AGA AAA AAC CCA AAC CCT TAT GAA ATG AGC TTA 296Ala Phe Ser Ala His Arg Lys Asn Pro Asn Pro Tyr Glu Met Ser Leu
70 75 80GAA GAA ATC CTA GAA AAG GTT AAA AAC TCC TAC AAC AAG GGG ATT AAA 344Glu Glu Ile Leu Glu Lys Val Lys Asn Ser Tyr Asn Lys Gly Ile Lys
85 90 95GAA GTC CAT ATC GTG AGC GCT CAT AAC CCT AAT TAC TCC TAT GAA TGG 392Glu Val His Ile Val Ser Ala His Asn Pro Asn Tyr Ser Tyr Glu Trp
100 105 110TAT TTA AAG GTG TTT GAA ACC ATC AAG CAA GAA ATG CCT AAC TTG CAT 440Tyr Leu Lys Val Phe Glu Thr Ile Lys Gln Glu Met Pro Asn Leu His115 120 125 130TTA AAG GCC ATG ACC GCT GCA GAA GTG CAT TTT TTA AGC GTT AAA TTC 488Leu Lys Ala Met Thr Ala Ala Glu Val His Phe Leu Ser Val Lys Phe
135 140 145AAC AAA CCT TTT GAA TTG GTG CTA GAA GAC ATG CTC AAA GCC GGG GTG 536Asn Lys Pro Phe Glu Leu Val Leu Glu Asp Met Leu Lys Ala Gly Val
150 155 160GAT TCC ATG CCT GGT GGG GGG GCG GAG ATT TTT GAT GAA GAA ATC AGG 584Asp Ser Met Pro Gly Gly Gly Ala Glu Ile Phe Asp Glu Glu lle Arg
165 170 175CGT AAA ATC TGT AAT GGT AAG GTG GGA TCT TCT CGG TGG TTA GAA ATC 632Arg Lys Ile Cys Asn Gly Lys Val Gly Ser Ser Arg Trp Leu Glu Ile
180 185 190CAT GCT TAT TGG CAC AAA TTA GGC AAA ATG AGT AAC GCT ACC ATG CTT 680His Ala Tyr Trp His Lys Leu Gly Lys Met Ser Asn Ala Thr Met Leu195 200 205 210TTT GGG CAT ATT GAA AAT AAA ATC CAT CGC ATC GAT CAC ATG CTA AGA 728Phe Gly His Ile Glu Asn Lys Ile His Arg Ile Asp His Met Leu Arg
215 220 225ATC AAA AAA ATC CAA AGC CCT AAA AAT CAA GTA GAA AAC AAA GAA GGG 776Ile Lys Lys Ile Gln Ser Pro Lys Asn Gln Val Glu Asn Lys Glu Gly
230 235 240GGT TTT AAC GCT TTT ATC CCC TTG TTG TAT CAA AAA GAA AAC AAT TAT 824Gly Phe Asn Ala Phe Ile Pro Leu Leu Tyr Gln Lys Glu Asn Asn Tyr
245 250 255TTG AAT GTG GAA AAA TCC CCC AGT GCG ATA GAA ATC TTA AAA ACC ATC 872Leu Asn Val Glu Lys Ser Pro Ser Ala Ile Glu Ile Leu Lys Thr Ile
260 265 270GCC ATA TCT CGC ATT CTT TTA AAC AAT ATC CCT CAC ATT AAA GCT TAT 920Ala Ile Ser Arg Ile Leu Leu Asn Asn Ile Pro His Ile Lys Ala Tyr275 280 285 290TGG GCG ACT TTG GGC TTG AAT TTG GCT TTA GTG GCT CAA GAA TTT GGC 968Trp Ala Thr Leu Gly Leu Asn Leu Ala Leu Val Ala Gln Glu Phe Gly
295 300 305GCT AAC GAT TTA GAC GGC ACG ATA GAG ATA GAG AGC ATT CAA AGC GCG 1016Ala Asn Asp Leu Asp Gly Thr Ile Glu Ile Glu Ser Ile Gln Ser Ala
310 315 320GCA GGC GCA AAG AGC CGG CAT GGT TTA GAA AAA GAA GAT TTG ATA TTT 1064Ala Gly Ala Lys Ser Arg His Gly Leu Glu Lys Glu Asp Leu Ile Phe
325 330 335AAA ATC AAG GAC GCT GGT TTT GTT GCG GTA GAA AGG GAT AGT TTG TAT 1112Lys Ile Lys Asp Ala Gly Phe Val Ala Val Glu Arg Asp Ser Leu Tyr
340 345 350AAT TTT ATA CAG AAA TTT TAATAATTTT TAGCGTTTTT AAGAATGATT AGTTATAA 1168Asn Phe Ile Gln Lys Phe355 360TAACGCTACT AACAA 1183
(2) Sequence 394 data:
(i) sequence characteristics:
(A) length: 360 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 394: met Asp Phe Leu Glu Lys Val Leu Asp Asn Gln Val Thr Glu Ser Lys 151015 Glu Leu Val Arg Leu Tyr Asp Tyr Asp Leu Tyr Thr Leu Gly Glu Val
20 25 30Ala Asp Arg Met Arg Gln Asn Met His Gln Lys Ile Val Tyr Phe Asn
35 40 45Val Asn Arg His Leu Asn Pro Ser Asn Ile Cys Ala Asp Ala Cys Lys
50 55 60Phe Cys Ala Phe Ser Ala His Arg Lys Asn Pro Asn Pro Tyr Glu Met65 70 75 80Ser Leu Glu Glu Ile Leu Glu Lys Val Lys Asn Ser Tyr Asn Lys Gly
85 9095Ile Lys Glu Val His Ile Val Ser Ala His Asn Pro Asn Tyr Ser Tyr
100 105 110Glu Trp Tyr Leu Lys Val Phe Glu Thr Ile Lys Gln Glu Met Pro Asn
115 120 125Leu His Leu Lys Ala Met Thr Ala Ala Glu Val His Phe Leu Ser Val
130 135 140Lys Phe Asn Lys Pro Phe Glu Leu Val Leu Glu Asp Met Leu Lys Ala145 150 155 160Gly Val Asp Ser Met Pro Gly Gly Gly Ala Glu Ile Phe Asp Glu Glu
165 170 175Ile Arg Arg Lys Ile Cys Asn Gly Lys Val Gly Ser Ser Arg Trp Leu
180 185 190Glu Ile His Ala Tyr Trp His Lys Leu Gly Lys Met Ser Asn Ala Thr
195 200 205Met Leu Phe Gly His Ile Glu Asn Lys Ile His Arg Ile Asp His Met
210 215 220Leu Arg Ile Lys Lys Ile Gln Ser Pro Lys Asn Gln Val Glu Asn Lys225 230 235 240Glu Gly Gly Phe Asn Ala Phe Ile Pro Leu Leu Tyr Gln Lys Glu Asn
245 250 255Asn Tyr Leu Asn Val Glu Lys Ser Pro Ser Ala Ile Glu Ile Leu Lys
260 265 270Thr Ile Ala Ile Ser Arg Ile Leu Leu Asn Asn Ile Pro His Ile Lys
275 280 285Ala Tyr Trp Ala Thr Leu Gly Leu Asn Leu Ala Leu Val Ala Gln Glu
290 295 300Phe Gly Ala Asn Asp Leu Asp Gly Thr Ile Glu Ile Glu Ser Ile Gln305 310 315320Ser Ala Ala Gly Ala Lys Ser Arg His Gly Leu Glu Lys Glu Asp Leu
325 330 335Ile Phe Lys Ile Lys Asp Ala Gly Phe Val Ala Val Glu Arg Asp Ser
340 345 350Leu Tyr Asn Phe Ile Gln Lys Phe
355 360
(2) Sequence 395 data:
(i) sequence characteristics:
(A) length: 616bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...563
(D) Other information:
(xi) Description of the sequence: sequence 395: TAATGAGAAT TAAACGAAAT TGGATACAAT CAGCTTAAAA AGGATATAAA GTG GAA 56
Val Glu
1AAA TTA CCT AAA AAA CGA GTT TCT AAA ACC AAA TCA CAA AAA CTT ATC 104Lys Leu Pro Lys Lys Arg Val Ser Lys Thr Lys Ser Gln Lys Leu Ile
5 10 15CAT AGC TTA ACC ACC CAA AAA AAC AGA GCC TTT CTC AAA AAA ATC AGC 152His Ser Leu Thr Thr Gln Lys Asn Arg Ala Phe Leu Lys Lys Ile Ser
20 25 30GCT AAT GAA ATG CTT TTA GAA TTA GAA AAA GGG GCG TTT AAA AAA AAT 200Ala Asn Glu Met Leu Leu Glu Leu Glu Lys Gly Ala Phe Lys Lys Asn3540 45 50GAA GCT TAT TTT ATT TCT GAT GAA GAA GAT AAA AAT TAT GTT TTG GTG 248Glu Ala Tyr Phe Ile Ser Asp Glu Glu Asp Lys Asn Tyr Val Leu Val
55 60 65CCA GAT AAC GTG ATC TCT CTT TTG GCA GAA AAC GCC AGA AAG GCT TTT 296Pro Asp Asn Val Ile Ser Leu Leu Ala Glu Asn Ala Arg Lys Ala Phe
70 75 80GAA GCC AGG CTT AGG GCG GAA TTA GAA AGG GAT ATT ATC ACC CAA GCG 344Glu Ala Arg Leu Arg Ala Glu Leu Glu Arg Asp Ile Ile Thr Gln Ala
85 90 95CCG ATT GAT TTT GAA GAC GTG CGC GAA GTT TCC TTG CAA CTA TTG GAA 392Pro Ile Asp Phe Glu Asp Val Arg Glu Val Ser Leu Gln Leu Leu Glu
100 105 110AAT TTA CGC CAA AAA GAT GGG AAT TTG CCT AAT ATC AAC ACC TTA AAC 440Asn Leu Arg Gln Lys Asp Gly Asn Leu Pro Asn Ile Asn Thr Leu Asn115 120 125 130TTT GTC AAA CAA ATC AAA AAA GAA CAC CCT AAT TTA TTC TTT AAT TTT 488Phe Val Lys Gln Ile Lys Lys Glu His Pro Asn Leu Phe Phe Asn Phe
135 140 145GAC AAC ATG TTC AAA CAA CCC CCT TTT AAT GAG AAT AAT TTT GAA AAT 536Asp Asn Met Phe Lys Gln Pro Pro Phe Asn Glu Asn Asn Phe Glu Asn
150 155 160TTT GAC AAT AGC GAT GAG GAA AAT TTT TAATGCAAAC CATTGATTTT GAAAAAT 590Phe Asp Asn Ser Asp Glu Glu Asn Phe
165 170TTTCACAATA TTCCAAGCCC GGCCCA 616
(2) Data in sequence 396:
(i) sequence characteristics:
(A) length: 171 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 396: val Glu Lys Leu Pro Lys Lys Arg Val Ser Lys Thr Lys Ser Gln Lys 151015 Leu Ile His Ser Leu Thr Thr Gln Lys Asn Arg Ala Phe Leu Lys Lys
20 25 30Ile Ser Ala Asn Glu Met Leu Leu Glu Leu Glu Lys Gly Ala Phe Lys
35 40 45Lys Asn Glu Ala Tyr Phe Ile Ser Asp Glu Glu Asp Lys Asn Tyr Val
50 55 60Leu Val Pro Asp Asn Val Ile Ser Leu Leu Ala Glu Asn Ala Arg Lys65 70 75 80Ala Phe Glu Ala Arg Leu Arg Ala Glu Leu Glu Arg Asp Ile Ile Thr
85 90 95Gln Ala Pro Ile Asp Phe Glu Asp Val Arg Glu Val Ser Leu Gln Leu
100 105 110Leu Glu Asn Leu Arg Gln Lys Asp Gly Asn Leu Pro Asn Ile Asn Thr
115 120 125Leu Asn Phe Val Lys Gln Ile Lys Lys Glu His Pro Asn Leu Phe Phe
130 135 140Asn Phe Asp Asn Met Phe Lys Gln Pro Pro Phe Asn Glu Asn Asn Phe145 150 155 160Glu Asn Phe Asp Asn Ser Asp Glu Glu Asn Phe
165 170
(2) Sequence 397 data:
(i) sequence characteristics:
(A) length: 952bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...899
(D) Other information:
(xi) Description of the sequence: sequence 397: GAGTTTGACG CGTATTTGCG TGGGGGCGAA AAACATTTCA GTAAAACGCT ATG AAT 56
Met Asn
1GAA AAT ATT AAT GAA AAT ATT TTT GAA GAA GTA GGG GAC GCT TGC GTT 104Glu Asn Ile Asn Glu Asn Ile Phe Glu Glu Val Gly Asp Ala Cys Val
5 10 15AAA TGC GCT AAG TGC GTG CCA GGC TGC ACC ATA TAC CGC ATT CAT AAA 152Lys Cys Ala Lys Cys Val Pro Gly Cys Thr Ile Tyr Arg Ile His Lys
20 25 30GAC GAG GCG ACT TCG CCT AGA GGC TTT TTA GAT TTG ATG CGC TTA AAC 200Asp Glu Ala Thr Ser Pro Arg Gly Phe Leu Asp Leu Met Arg Leu Asn35 40 45 50GCT CAA AAC AAG CTC CAA TTA GAC ACG AAT TTA AAA CAC CTT TTA GAA 248Ala Gln Asn Lys Leu Gln Leu Asp Thr Asn Leu Lys His Leu Leu Glu
55 60 65ACT TGC TTT TTA TGC ACC GCT TGC GTG GAA ATT TGC CCT TTT CAT TTG 296Thr Cys Phe Leu Cys Thr Ala Cys Val Glu Ile Cys Pro Phe His Leu
70 75 80CCC ATA GAC ACC TTA ATAGAA AAA GCC AGA GAA AAA ATC GCT CAA AAG 344Pro Ile Asp Thr Leu Ile Glu Lys Ala Arg Glu Lys Ile Ala Gln Lys
85 90 95CAT GGC ATC GCT TGG TAT AAA AAA TCC TAT TTT TCC CTT TTA AAA AAC 392His Gly Ile Ala Trp Tyr Lys Lys Ser Tyr Phe Ser Leu Leu Lys Asn
100 105 110CGC AAA AAA ATG GAT AGG GTG TTT TCA ACT GCG CAT TTT TTA GCC CCT 440Arg Lys Lys Met Asp Arg Val Phe Ser Thr Ala His Phe Leu Ala Pro115 120 125 130TGC GTT TTC AAG CAA GTA GGG GAT AGT TTA GAG CCT AGG GCG GTG TTT 488Cys Val Phe Lys Gln Val Gly Asp Ser Leu Glu Pro Arg Ala Val Phe
135 140 145AAA GGT TTG TTC AAA CGC TTT AAA AAA AGC GCG CTG CCT CCT TTA AAT 536Lys Gly Leu Phe Lys Arg Phe Lys Lys Ser Ala Leu Pro Pro Leu Asn
150 155 160CAA AAA AGT TTT TTA CAA AAG CAT GCA GAA ATG AAG CTT TTA GAA AAC 584Gln Lys Ser Phe Leu Gln Lys His Ala Glu Met Lys Leu Leu Glu Asn
165 170 175CCC ATT CAA AAA GTG GCC ATT TTT ATA GGG TGC TTG AGC AAT TAC CAT 632Pro Ile Gln Lys Val Ala Ile Phe Ile Gly Cys Leu Ser Asn Tyr His
180 185 190TAC CAG CAA GTG GGG GAA AGC TTG TTG TAT ATT TTA GAA AAA CTC AAC 680Tyr Gln Gln Val Gly Glu Ser Leu Leu Tyr Ile Leu Glu Lys Leu Asn195 200 205 210ATT CAA GCG ATC ATC CCT AAG CAA GAA TGC TGC TCA GCG CCT GCG TAT 728Ile Gln Ala Ile Ile Pro Lys Gln Glu Cys Cys Ser Ala Pro Ala Tyr
215 220 225TTT ACC GGC GAT AAA GAC ACC ACG CTT TTT TTA GTG AAA AAA AAC ATA 776Phe Thr Gly Asp Lys Asp Thr Thr Leu Phe Leu Val Lys Lys Asn Ile
230 235 240GAA TGG TTT GAA AGC TAT TTA GAT AAA GTG GAT GCG ATC ATT GTG CCT 824Glu Trp Phe Glu Ser Tyr Leu Asp Lys Val Asp Ala Ile Ile Val Pro
245 250 255GAA GCC ACA TGC GCT ACA TGC TCA TCA ACG ATT ATT ACA AGG TGT TTT 872Glu Ala Thr Cys Ala Thr Cys Ser Ser Thr Ile Ile Thr Arg Cys Phe
260 265 270TGG GCG AAA AAG ATA AGG ATT TGT ATG TGAAGCGCTT GGAAAAAATC ACGCCTA 926Trp Ala Lys Lys Ile Arg Ile Cys Met275 280AAATCTATCT GGCGAGCGTG TTTTTA 952
(2) Sequence 398 data:
(i) sequence characteristics:
(A) length: 283 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 398: met Asn Glu Asn Ile Asn Glu Asn Ile Phe Glu Glu Val Gly Asp Ala 151015 Cys Val Lys Cys Ala Lys Cys Val Pro Gly Cys Thr Ile Tyr Arg Ile
20 25 30His Lys Asp Glu Ala Thr Ser Pro Arg Gly Phe Leu Asp Leu Met Arg
35 40 45Leu Asn Ala Gln Asn Lys Leu Gln Leu Asp Thr Asn Leu Lys His Leu
50 55 60Leu Glu Thr Cys Phe Leu Cys Thr Ala Cys Val Glu Ile Cys Pro Phe65 70 75 80His Leu Pro Ile Asp Thr Leu Ile Glu Lys Ala Arg Glu Lys Ile Ala
85 90 95Gln Lys His Gly Ile Ala Trp Tyr Lys Lys Ser Tyr Phe Ser Leu Leu
100 105 110Lys Asn Arg Lys Lys Met Asp Arg Val Phe Ser Thr Ala His Phe Leu
115 120 125Ala Pro Cys Val Phe Lys Gln Val Gly Asp Ser Leu Glu Pro Arg Ala
130 135 140Val Phe Lys Gly Leu Phe Lys Arg Phe Lys Lys Ser Ala Leu Pro Pro145 150 155 160Leu Asn Gln Lys Ser Phe Leu Gln Lys His Ala Glu Met Lys Leu Leu
165 170 175Glu Asn Pro Ile Gln Lys Val Ala Ile Phe Ile Gly Cys Leu Ser Asn
180 185 190Tyr His Tyr Gln Gln Val Gly Glu Ser Leu Leu Tyr Ile Leu Glu Lys
195 200 205Leu Asn Ile Gln Ala Ile Ile Pro Lys Gln Glu Cys Cys Ser Ala Pro
210 215 220Ala Tyr Phe Thr Gly Asp Lys Asp Thr Thr Leu Phe Leu Val Lys Lys225 230 235 240Asn Ile Glu Trp Phe Glu Ser Tyr Leu Asp Lys Val Asp Ala Ile Ile
245 250 255Val Pro Glu Ala Thr Cys Ala Thr Cys Ser Ser Thr Ile Ile Thr Arg
260 265 270Cys Phe Trp Ala Lys Lys Ile Arg Ile Cys Met
275 280
(2) Data of sequence 399:
(i) sequence characteristics:
(A) length: 1361 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...1305
(D) Other information:
(xi) Description of the sequence: sequence 399: TATTGATAGC ATGAGTTGTT TTTGGTTTGG AATTTTAAGG AGTAGCTT ATG AAA GAG 57
Met Lys Glu
1CAA TCA ATG ATT GAT TTT TTA AAA CTT AGA GAT TAT GAC ATT AGA AAA 105Gln Ser Met Ile Asp Phe Leu Lys Leu Arg Asp Tyr Asp Ile Arg Lys
5 10 15ACA CAA AAT GCG CGA TGG ATA GAT CAA AAA TGC ACC CCT GAT GTG TTG 153Thr Gln Asn Ala Arg Trp Ile Asp Gln Lys Cys Thr Pro Asp Val Leu20 25 30 35TCT CTT GTT GCT GAT TGT ATT TTA GAG TTT ACG CAA TGT AAT ATT GGA 201Ser Leu Val Ala Asp Cys Ile Leu Glu Phe Thr Gln Cys Asn Ile Gly
40 45 50AAA TCA TTT TCT ATT AGG GAT ATT TGG GAT AGC CCT TAC ACC AAT GAA 249Lys Ser Phe Ser Ile Arg Asp Ile Trp Asp Ser Pro Tyr Thr Asn Glu
55 60 65AAT GTT AAA ATG ATT TTT TCT AAA CCT GAT TTA AAT TCT GAC TTT TCC 297Asn Val Lys Met Ile Phe Ser Lys Pro Asp Leu Asn Ser Asp Phe Ser
70 75 80ATG CAT GAA TAC GAT AAG TTT TTT TCT CAG CCT ATT AAA TTA TTA GCC 345Met His Glu Tyr Asp Lys Phe Phe Ser Gln Pro Ile Lys Leu Leu Ala
85 90 95TAT AGC GGT ATT TTA TTT GAA ACA AAA ACT GGC AAT AGA AAT ATT TAT 393Tyr Ser Gly Ile Leu Phe Glu Thr Lys Thr Gly Asn Arg Asn Ile Tyr100 105 110 115ACC ATA CAA AAC ATA GAG CTA TTA GAA TAT CTC ATG CAA AGA GAA ACA 441Thr Ile Gln Asn Ile Glu Leu Leu Glu Tyr Leu Met Gln Arg Glu Thr
120 125 130AAC GCT TTG AAA TTC CTT ATT TTA TAT ATT CAA AAG GTA TTA ATG GAT 489Asn Ala Leu Lys Phe Leu Ile Leu Tyr Ile Gln Lys Val Leu Met Asp
135 140 145AGT GGG ATT TAT CCT TTA TTT GAC AAC TTT TTA CAA AAA CAA GAC ACA 537Ser Gly Ile Tyr Pro Leu Phe Asp Asn Phe Leu Gln Lys Gln Asp Thr
150 155 160GAA AGT TTT AAG CAA CTA AAA GAT GGT TTC ACT CAT TTT ACT ATC AAT 585Glu Ser Phe Lys Gln Leu Lys Asp Gly Phe Thr His Phe Thr Ile Asn
165 170 175AAC ACA GCA ATC AAT AAC GCT ACG GAA TGT TTT AGG ATT TTT ACT AAA 633Asn Thr Ala Ile Asn Asn Ala Thr Glu Cys Phe Arg Ile Phe Thr Lys180 185 190 195ATT ATC AAT CCT TTA GCT TTT TAT TAT GGT AAA AAA GGC ACA AGA AAA 681Ile Ile Asn Pro Leu Ala Phe Tyr Tyr Gly Lys Lys Gly Thr Arg Lys
200 205 210GGG TAT TTG TCC AAC ACT ATA ATT ACA AAA GAT GAG CTT AAT TAT AAT 729Gly Tyr Leu Ser Asn Thr Ile Ile Thr Lys Asp Glu Leu Asn Tyr Asn
215 220 225CGT ATC AAT TGG CGA GAT ATA GGA AAA GAT AAA AAT ACC ACC AGA CAA 777Arg Ile Asn Trp Arg Asp Ile Gly Lys Asp Lys Asn Thr Thr Arg Gln
230 235 240GAA TAC GAT CTT ATA AAC TCT AAA AGG ATT GCT AAT TCT AAC TAT CTT 825Glu Tyr Asp Leu Ile Asn Ser Lys Arg Ile Ala Asn Ser Asn Tyr Leu
245 250 255ATT TCA AAA GCT AAG AAA GTG GTG AAA CGA TAT AAT GAT AGA TTT AAT 873Ile Ser Lys Ala Lys Lys Val Val Lys Arg Tyr Asn Asp Arg Phe Asn260 265 270 275AAT TCT CTC TCT GAA GTA AAA CAA GAA AAA GAA GAG TCG CAA GCC ACA 921Asn Ser Leu Ser Glu Val Lys Gln Glu Lys Glu Glu Ser Gln Ala Thr
280 285 290CAA ATA CAC CAT ATT TTT CCC ATC CAA GAC TTT CCC ATT ATT GCT AAC 969Gln Ile His His Ile Phe Pro Ile Gln Asp Phe Pro Ile Ile Ala Asn
295 300 305TAT ATA GAG AAT CTT ATC GCA CTC ACT CCT AAT CAA CAT TTT ATT TAC 1017Tyr Ile Glu Asn Leu Ile Ala Leu Thr Pro Asn Gln His Phe Ile Tyr
310 315 320GCC CAC CCT AAT AAT CAA ACC CGC TTG ATT GAT AAA GAT TTT CAA TAT 1065Ala His Pro Asn Asn Gln Thr Arg Leu Ile Asp Lys Asp Phe Gln Tyr
325 330 335ATC TGC TTA TTA GCT AAA ACG ACC ACA ATT CTT AAT GAC ACT CAA GGC 1113Ile Cys Leu Leu Ala Lys Thr Thr Thr Ile Leu Asn Asp Thr Gln Gly340 345 350 355GTA TAT GAT TGG AAT GAT TAT ATT GTT GTG TTG AAT ATG GGC CTC AAA 1161Val Tyr Asp Trp Asn Asp Tyr Ile Val Val Leu Asn Met Gly Leu Lys
360 365 370ACA ACT ATC TTT TCT CAA GTC AAG AAC GAA TGG GAA TTA TTA AAA GTA 1209Thr Thr Ile Phe Ser Gln Val Lys Asn Glu Trp Glu Leu Leu Lys Val
375 380 385ATA GAT GCT TTT TATTTT GAT TTT AAC AAG AGC AAA GAT CCA AGT TGG 1257Ile Asp Ala Phe Tyr Phe Asp Phe Asn Lys Ser Lys Asp Pro Ser Trp
390 395 400TCA TAC TTG CTA GAT AAA AAC GAT TTA AGA GCT TTC AAG CTA AAA TTT T 1306Ser Tyr Leu Leu Asp Lys Asn Asp Leu Arg Ala Phe Lys Leu Lys Phe
405 410 415AATAAGTTTT ATTGAAACTG GCTATAAAAA CCCGCTTGAC TTATCTTATC CTTTT 1361
(2) Sequence 400 data:
(i) sequence characteristics:
(A) length: 419 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 400: met Lys Glu Gln Ser Met Ile Asp Phe Leu Lys Leu Arg Asp Tyr Asp 151015 Ile Arg Lys Thr Gln Asn Ala Arg Trp Ile Asp Gln Lys Cys Thr Pro
20 25 30Asp Val Leu Ser Leu Val Ala Asp Cys Ile Leu Glu Phe Thr Gln Cys
35 40 45Asn Ile Gly Lys Ser Phe Ser Ile Arg Asp Ile Trp Asp Ser Pro Tyr
50 55 60Thr Asn Glu Asn Val Lys Met Ile Phe Ser Lys Pro Asp Leu Asn Ser65 70 75 80Asp Phe Ser Met His Glu Tyr Asp Lys Phe Phe Ser Gln Pro Ile Lys
85 90 95Leu Leu Ala Tyr Ser Gly Ile Leu Phe Glu Thr Lys Thr Gly Asn Arg
100105 110Asn Ile Tyr Thr Ile Gln Asn Ile Glu Leu Leu Glu Tyr Leu Met Gln
115 120 125Arg Glu Thr Asn Ala Leu Lys Phe Leu Ile Leu Tyr Ile Gln Lys Val
130 135 140Leu Met Asp Ser Gly Ile Tyr Pro Leu Phe Asp Asn Phe Leu Gln Lys145 150 155 160Gln Asp Thr Glu Ser Phe Lys Gln Leu Lys Asp Gly Phe Thr His Phe
165 170 175Thr Ile Asn Asn Thr Ala Ile Asn Asn Ala Thr Glu Cys Phe Arg Ile
180 185 190Phe Thr Lys Ile Ile Asn Pro Leu Ala Phe Tyr Tyr Gly Lys Lys Gly
195 200 205Thr Arg Lys Gly Tyr Leu Ser Asn Thr Ile Ile Thr Lys Asp Glu Leu
210 215 220Asn Tyr Asn Arg Ile Asn Trp Arg Asp Ile Gly Lys Asp Lys Asn Thr225 230 235 240Thr Arg Gln Glu Tyr Asp Leu Ile Asn Ser Lys Arg Ile Ala Asn Ser
245 250 255Asn Tyr Leu Ile Ser Lys Ala Lys Lys ValVal Lys Arg Tyr Asn Asp
260 265 270Arg Phe Asn Asn Ser Leu Ser Glu Val Lys Gln Glu Lys Glu Glu Ser
275 280 285Gln Ala Thr Gln Ile His His Ile Phe Pro Ile Gln Asp Phe Pro Ile
290 295 300Ile Ala Asn Tyr Ile Glu Asn Leu Ile Ala Leu Thr Pro Asn Gln His305 310 315 320Phe Ile Tyr Ala His Pro Asn Asn Gln Thr Arg Leu Ile Asp Lys Asp
325330 335Phe Gln Tyr Ile Cys Leu Leu Ala Lys Thr Thr Thr Ile Leu Asn Asp
340 345 350Thr Gln Gly Val Tyr Asp Trp Asn Asp Tyr Ile Val Val Leu Asn Met
355 360 365Gly Leu Lys Thr Thr Ile Phe Ser Gln Val Lys Asn Glu Trp Glu Leu
370 375 380Leu Lys Val Ile Asp Ala Phe Tyr Phe Asp Phe Asn Lys Ser Lys Asp385 390 395 400Pro Ser Trp Ser Tyr Leu Leu Asp Lys Asn Asp Leu Arg Ala Phe Lys
405 410 415Leu Lys Phe
(2) Sequence 401 data:
(i) sequence characteristics:
(A) length: 763bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 53...709
(D) Other information:
(xi) Description of the sequence: sequence 401: AAATAAGCTA ATCTTTGCTA AAATGAGATT TAAAATTATT TAAGGAAGAT GA ATG CTT 58
Met Leu
1TTT GCG ATG ATT GGT TCA GGG GGG TTT ATC GCT CCC AAG CAC TTG CAA 106Phe Ala Met Ile Gly Ser Gly Gly Phe Ile Ala Pro Lys His Leu Gln
5 10 15GCG ATT AGA GAT ACA GGG CAT TTT TTG GAT TGC TCT TTT GAT ATT CAT 154Ala Ile Arg Asp Thr Gly His Phe Leu Asp Cys Ser Phe Asp Ile His
20 25 30GAT AGC GTG GGG GTT TTA GAT GAG TAT TTC GCG CAA TCA GAG TTT TTT 202Asp Ser ValGly Val Leu Asp Glu Tyr Phe Ala Gln Ser Glu Phe Phe35 40 45 50ACG AAT ATT GAA GAT TTT GAA AAG CAT TTA GAG CAA TCT AAG GAT ATG 250Thr Asn Ile Glu Asp Phe Glu Lys His Leu Glu Gln Ser Lys Asp Met
55 60 65GGT AAA GAA ATC AAC TAT TTG AGT GTT TGC ACG CCT ACG CAC ACG CAT 298Gly Lys Glu Ile Asn Tyr Leu Ser Val Cys Thr Pro Thr His Thr His
70 75 80TTT GAT CAC ATC CGT TTC GGG TTA AGA AAC GGC ATG CAT GTG ATT TGT 346Phe Asp His Ile Arg Phe Gly Leu Arg Asn Gly Met His Val Ile Cys
85 90 95GAA AAA CCC TTA GTT TTA GAC CCT GGC GAA ATA CAA GAA TTG AAA GAT 394Glu Lys Pro Leu Val Leu Asp Pro Gly Glu Ile Gln Glu Leu Lys Asp
100 105 110TTA GAG GTG AAA CAC CAA AAA AGG GTG TTT AGT CTT TTA CCC TTG CGC 442Leu Glu Val Lys His Gln Lys Arg Val Phe Ser Leu Leu Pro Leu Arg115 120 125 130TTG CAT TGC GAC ACG CTG GCT TTG AAA GAA AAA ATT AAG AGC GAA TTA 490Leu His Cys Asp Thr Leu Ala Leu Lys Glu Lys Ile Lys Ser Glu Leu
135 140 145GAC AAA AAC CCT AGC AAG GTG TTT GAC ATC ACG CTC ACT TAT ATC AGC 538Asp Lys Asn Pro Ser Lys Val Phe Asp Ile Thr Leu Thr Tyr Ile Ser
150 155 160GTT CAA GGG AAA TGG TAT TTT TCT TCA TGG CGA GCG GAT GTG AAT AGG 586Val Gln Gly Lys TrpTyr Phe Ser Ser Trp Arg Ala Asp Val Asn Arg
165 170 175AGC GGA GGG TTA GCC ACT CAA ATG GGG GTG AAT ATT TTT GAC ACT TTA 634Ser Gly Gly Leu Ala Thr Gln Met Gly Val Asn Ile Phe Asp Thr Leu
180 185 190ATC TAT TTG TTT GGA AGC GTT AAA GAC AAG GTT ATC AAT AAA GAA GAG 682Ile Tyr Leu Phe Gly Ser Val Lys Asp Lys Val Ile Asn Lys Glu Glu195 200 205 210CCT GAT TGC GTA GGG GGA TAC TCT TTT TAGAGCATGC CAAAATAAGA TGGTTTT 736Pro Asp Cys Val Gly Gly Tyr Ser Phe
215TTTCCATCAA TCCAGAACAC ATGGGAG 763
(2) Sequence 402 data:
(i) sequence characteristics:
(A) length: 219 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 402: met Leu Phe Ala Met Ile Gly Ser Gly Gly Phe Ile Ala Pro Lys His 151015 Leu Gln Ala Ile Arg Asp Thr Gly His Phe Leu Asp Cys Ser Phe Asp
20 25 30Ile His Asp Ser Val Gly Val Leu Asp Glu Tyr Phe Ala Gln Ser Glu
35 40 45Phe Phe Thr Asn Ile Glu Asp Phe Glu Lys His Leu Glu Gln Ser Lys
50 55 60Asp Met Gly Lys Glu Ile Asn Tyr Leu Ser Val Cys Thr Pro Thr His65 70 75 80Thr HisPhe Asp His Ile Arg Phe Gly Leu Arg Asn Gly Met His Val
85 90 95Ile Cys Glu Lys Pro Leu Val Leu Asp Pro Gly Glu Ile Gln Glu Leu
100 105 110Lys Asp Leu Glu Val Lys His Gln Lys Arg Val Phe Ser Leu Leu Pro
115 120 125Leu Arg Leu His Cys Asp Thr Leu Ala Leu Lys Glu Lys Ile Lys Ser
130 135 140Glu Leu Asp Lys Asn Pro Ser Lys Val Phe Asp Ile Thr Leu Thr Tyr145 150 155 160Ile Ser Val Gln Gly Lys Trp Tyr Phe Ser Ser Trp Arg Ala Asp Val
165 170 175Asn Arg Ser Gly Gly Leu Ala Thr Gln Met Gly Val Asn Ile Phe Asp
180 185 190Thr Leu Ile Tyr Leu Phe Gly Ser Val Lys Asp Lys Val Ile Asn Lys
195 200 205Glu Glu Pro Asp Cys Val Gly Gly Tyr Ser Phe
210 215
(2) Sequence 403 data:
(i) sequence characteristics:
(A) length: 1465bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1412
(D) Other information:
(xi) Description of the sequence: sequence 403: GACAGAAGCT GAATTTGAGG TGCGCTTATA GCTTGTAAAA GGGGGTGTTT ATG TTT 56
Met Phe
1TTA TTA AGG CAT TTG ACT TCA GCG TGC GTG TTT TTG GCG TCT AAA TGT 104Leu Leu Arg His Leu Thr Ser Ala Cys Val Phe Leu Ala Ser Lys Cys
5 10 15TTG CCG GAC TCC TTT GTC TTG GTC GCT CTT TTA TCG TTT GTC GTG TTT 152Leu Pro Asp Ser Phe Val Leu Val Ala Leu Leu Ser Phe Val Val Phe
20 25 30GTT CTT GTT TAT TGC TTG ACA GGG CAA GAC GCT TTT TCT GTC ATT TCT 200Val Leu Val Tyr Cys Leu Thr Gly Gln Asp Ala Phe Ser Val Ile Ser35 40 45 50AGT TGG GGG AAT GGC GCT TGG ACG CTT TTA GGT TTT TCT ATG CAA ATG 248Ser Trp Gly Asn Gly Ala Trp Thr Leu Leu Gly Phe Ser Met Gln Met
55 60 65GCC CTT ATT TTG GTG TTG GGT CAG GCT CTG GCT AAC GCT AAA TTA GTC 296Ala Leu Ile Leu Val Leu Gly Gln Ala Leu Ala Asn Ala Lys Leu Val
70 75 80CAA AAG CTT TTA AAA TAT CTA GCG TCT TTA CCT AAA GGG TAT TAT ACG 344Gln Lys Leu Leu Lys Tyr Leu Ala Ser Leu Pro Lys Gly Tyr Tyr Thr
85 90 95GCT TTA TGG TTG GTT ACT TTT TTA TCG TTA ATC GCT AAT TGG ATC AAC 392Ala Leu Trp Leu Val Thr Phe Leu Ser Leu Ile Ala Asn Trp Ile Asn
100 105 110TGG GGT TTT GGC TTG GTG ATT AGT GCG ATT TTT GCA AAA GAG ATC GCC 440Trp Gly Phe Gly Leu Val Ile Ser Ala Ile Phe Ala Lys Glu Ile Ala115 120 125 130AAA AAT GTTAAG GGG GTG GAT TAC AGG CTG CTC ATT GCT AGC GCT TAT 488Lys Asn Val Lys Gly Val Asp Tyr Arg Leu Leu Ile Ala Ser Ala Tyr
135 140 145TCG GGT TTT GTC ATC TGG CAT GGG GGT TTA TCA GGC TCT ATC CCT TTA 536Ser Gly Phe Val Ile Trp His Gly Gly Leu Ser Gly Ser Ile Pro Leu
150 155 160AGC GTT GCC ACC CAA AAT GAA AAT CTA TCC AAA ATA AGC GCT GGG GTG 584Ser Val Ala Thr Gln Asn Glu Asn Leu Ser Lys Ile Ser Ala Gly Val
165 170 175ATT GAA AAA GCT ATC CCT ATC AGT CAG ACG ATT TTT TCT TCT TAT AAT 632Ile Glu Lys Ala Ile Pro Ile Ser Gln Thr Ile Phe Ser Ser Tyr Asn
180 185 190TTA ATC ATT ATA GGG ATC ATT CTT GTA GGG TTA CCC TTT TTA ATG GCA 680Leu Ile Ile Ile Gly Ile Ile Leu Val Gly Leu Pro Phe Leu Met Ala195 200 205 210ATG ATC CAC CCT AAA AAA GAA GAA ATC GTT GAG ATT GAT TCA AAG CTT 728Met Ile His Pro Lys Lys Glu Glu Ile Val Glu Ile Asp Ser Lys Leu
215 220 225TTA AAA GAC GAG TAC AAA GAG ATT GAA CTC ATT AGC CAC CAA CAA GAC 776Leu Lys Asp Glu Tyr Lys Glu Ile Glu Leu Ile Ser His Gln Gln Asp
230 235 240AAA ACG ATC GCG CAT TTT TTG GAA AAC AGC GCT TTG CTT TCT TAT CTT 824Lys Thr Ile Ala His Phe Leu Glu Asn Ser Ala Leu Leu Ser Tyr Leu
245 250 255TTG GTT TTT TTG GGT TTT GGG TAT CTT GGT GTT TAT TTT TTT AAA GGG 872Leu Val Phe Leu Gly Phe Gly Tyr Leu Gly Val Tyr Phe Phe Lys Gly
260 265 270GGA GGG ATT AGT TTA AAC ATT GTC AAT ACG ATT TTC CTT TTT TTA GGG 920Gly Gly Ile Ser Leu Asn Ile Val Asn Thr Ile Phe Leu Phe Leu Gly275 280 285 290ATT TTA CTG CAT AAA ACC CCT TTA GCT TAT GTG AAA GCG ATC GAT CGT 968Ile Leu Leu His Lys Thr Pro Leu Ala Tyr Val Lys Ala Ile Asp Arg
295 300 305TCC GCT ANG AGC GTG GCT GGG ATT TTA TTG CAA TTC CCT TTT TAC GCT 1016Ser Ala Xaa Ser Val Ala Gly Ile Leu Leu Gln Phe Pro Phe Tyr Ala
310 315 320GGG ATT ATG GGG ATG ATG GCA AGC CAT AGC GTG GGG GGT CAT TCT TTA 1064Gly Ile Met Gly Met Met Ala Ser His Ser Val Gly Gly His Ser Leu
325 330 335GCG CAA ATG CTT TCT TTA GCT TTC ACG CAC ATC GCT AAT GAA AAA ACT 1112Ala Gln Met Leu Ser Leu Ala Phe Thr His Ile Ala Asn Glu Lys Thr
340 345 350TTC GTG CTC ATG ACT TTT TTG AGC GCA GGG ATT GTC AAT ATT TTT ATT 1160Phe Val Leu Met Thr Phe Leu Ser Ala Gly Ile Val Asn Ile Phe Ile355 360 365 370CCG TCT GGC GGA GGG CAA TGG GCG ATT CAA GCT CCT ATC ATG CTT CCG 1208Pro Ser Gly Gly Gly Gln Trp Ala Ile Gln Ala Pro Ile Met Leu Pro
375 380 385GCT GGG CAA AGC TTA GGG GTG GAT CCG GGA GTG GTT TCT ATG GCT ATC 1256Ala Gly Gln Ser Leu Gly Val Asp Pro Gly Val Val Ser Met Ala Ile
390 395 400GCT TGG GGA GAT GCT TGG ACG AAT ATG ATA CAG CCT TTT TGG GCT TTG 1304Ala Trp Gly Asp Ala Trp Thr Asn Met Ile Gln Pro Phe Trp Ala Leu
405 410 415CCC GCT TTA GCC ATT GCG GGT TTG GGC GCT AAA GAT ATT ATG GGC TAT 1352Pro Ala Leu Ala Ile Ala Gly Leu Gly Ala Lys Asp Ile Met Gly Tyr
420 425 430TGC GTT TTG ACT TTA ATT TTT GTA GGC TTA GTC GTG TGT GGG GTG TTT 1400Cys Val Leu Thr Leu Ile Phe Val Gly Leu Val Val Cys Gly Val Phe435 440 445 450TAT TTT TTA GTG TGAGTTTTTT ATGCCTAAAA CCATGCTCTT TTCAATGGGG TAAGG 1457Tyr Phe Leu ValTTTTCTCT 1465
(2) Sequence 404 data:
(i) sequence characteristics:
(A) length: 454 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 404: met Phe Leu Leu Arg His Leu Thr Ser Ala Cys Val Phe Leu Ala Ser 151015 Lys Cys Leu Pro Asp Ser Phe Val Leu Val Ala Leu Leu Ser Phe Val
20 25 30Val Phe Val Leu ValTyr Cys Leu Thr Gly Gln Asp Ala Phe Ser Val
35 40 45Ile Ser Ser Trp Gly Asn Gly Ala Trp Thr Leu Leu Gly Phe Ser Met
50 55 60Gln Met Ala Leu Ile Leu Val Leu Gly Gln Ala Leu Ala Asn Ala Lys65 70 75 80Leu Val Gln Lys Leu Leu Lys Tyr Leu Ala Ser Leu Pro Lys Gly Tyr
85 90 95Tyr Thr Ala Leu Trp Leu Val Thr Phe Leu Ser Leu Ile Ala Asn Trp
100 105 110Ile Asn Trp Gly Phe Gly Leu Val Ile Ser Ala Ile Phe Ala Lys Glu
115 120 125Ile Ala Lys Asn Val Lys Gly Val Asp Tyr Arg Leu Leu Ile Ala Ser
130 135 140Ala Tyr Ser Gly Phe Val Ile Trp His Gly Gly Leu Ser Gly Ser Ile145 150 155 160Pro Leu Ser Val Ala Thr Gln Asn Glu Asn Leu Ser Lys Ile Ser Ala
165 170 175Gly Val Ile Glu Lys Ala Ile Pro Ile Ser Gln Thr Ile Phe Ser Ser
180 185 190Tyr Asn Leu Ile Ile Ile Gly Ile Ile Leu Val Gly Leu Pro Phe Leu
195 200 205Met Ala Met Ile His Pro Lys Lys Glu Glu Ile Val Glu Ile Asp Ser
210 215 220Lys Leu Leu Lys Asp Glu Tyr Lys Glu Ile Glu Leu Ile Ser His Gln225 230 235 240Gln Asp Lys Thr Ile Ala His Phe Leu Glu Asn Ser Ala Leu Leu Ser
245 250 255Tyr Leu Leu Val Phe Leu Gly Phe Gly Tyr Leu Gly Val Tyr Phe Phe
260 265 270Lys Gly Gly Gly Ile Ser Leu Asn Ile Val Asn Thr Ile Phe Leu Phe
275 280 285Leu Gly Ile Leu Leu His Lys Thr Pro Leu Ala Tyr Val Lys Ala Ile
290 295 300Asp Arg Ser Ala Xaa Ser Val Ala Gly Ile Leu Leu Gln Phe Pro Phe305 310 315 320Tyr Ala Gly Ile Met Gly Met Met Ala Ser His Ser Val Gly Gly His
325 330 335Ser Leu Ala Gln Met Leu Ser Leu Ala Phe Thr HisIle Ala Asn Glu
340 345 350Lys Thr Phe Val Leu Met Thr Phe Leu Ser Ala Gly Ile Val Asn Ile
355 360 365Phe Ile Pro Ser Gly Gly Gly Gln Trp Ala Ile Gln Ala Pro Ile Met
370 375 380Leu Pro Ala Gly Gln Ser Leu Gly Val Asp Pro Gly Val Val Ser Met385 390 395 400Ala Ile Ala Trp Gly Asp Ala Trp Thr Asn Met Ile Gln Pro Phe Trp
405 410 415Ala Leu Pro Ala Leu Ala Ile Ala Gly Leu Gly Ala Lys Asp Ile Met
420 425 430Gly Tyr Cys Val Leu Thr Leu Ile Phe Val Gly Leu Val Val Cys Gly
435 440 445Val Phe Tyr Phe Leu Val
450
(2) Sequence 405 data:
(i) sequence characteristics:
(A) length: 1114bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1061
(D) Other information:
(xi) Description of the sequence: sequence 405: TATCACTATA CTTTCAATAA AATAAGGGGT TTTTTTTGAC TAAAAAATTC ATG TCT 56
Met Ser
1TGG ATG GTG GTT ATT GGG GCT TTA ATT TGC ATG CTT TTA GGG GTG TTT 104Trp Met Val Val Ile Gly Ala Leu Ile Cys Met Leu Leu Gly Val Phe
5 10 15ATC TTC TTC ACT AGC ATG TCG GTT AAA AAA TTT TTA AGC GCT TAT CTT 152Ile Phe Phe Thr Ser Met Ser Val Lys Lys Phe Leu Ser Ala Tyr Leu
20 25 30AAC GCT TAT TTG GAT CAA CGC CCC CAT ATT AAG GGC ATG GGG ATT GCA 200Asn Ala Tyr Leu Asp Gln Arg Pro His Ile Lys Gly Met Gly Ile Ala35 40 45 50GGC ACT CCC TTT GAA TGC GAA GGG TTT TTT AAA ATC GCA TGC GTT TCT 248Gly Thr Pro Phe Glu Cys Glu Gly Phe Phe Lys Ile Ala Cys Val Ser
55 60 65AAA GAG CTC AGT TTT TTA GAC TCT CAA AAC TCC CCT ATT GTG AAT TTT 296Lys Glu Leu Ser Phe Leu Asp Ser Gln Asn Ser Pro Ile Val Asn Phe
70 75 80AAA AAT TTG AGT ATT AAG CTC CGT TCT TTA GAT AAA AGC TCT CTT ACT 344Lys Asn Leu Ser Ile Lys Leu Arg Ser Leu Asp Lys Ser Ser Leu Thr
85 90 95CTT TCT GTC CAT TCT CAA ATC AAA TCC CCT ATT TTA GAA CAA GAT ATG 392Leu Ser Val His Ser Gln Ile Lys Ser Pro Ile Leu Glu Gln Asp Met
100 105 110CAG CAA AAA ATC AGC CAA ATC CCC CTA AAA GAC TTG AAT GCC TTA TTA 440Gln Gln Lys Ile Ser Gln Ile Pro Leu Lys Asp Leu Asn Ala Leu Leu115 120 125 130GAA AAA ATG AAA CCC ACG CGC TTG AAT TGC TCT TTA ACA TTC AAC GCT 488Glu Lys Met Lys Pro Thr Arg Leu Asn Cys Ser Leu Thr Phe Asn Ala
135 140 145CTA GAT GAAAAA ACC TTA AAC GAC AAC TTA AAA TGC GAT TTG ACT AAT 536Leu Asp Glu Lys Thr Leu Asn Asp Asn Leu Lys Cys Asp Leu Thr Asn
150 155 160GCG GAA AAT ATC CTT GCT TAC ACT TTT TTT CAA GAG GGT TTA ATG GAG 584Ala Glu Asn Ile Leu Ala Tyr Thr Phe Phe Gln Glu Gly Leu Met Glu
165 170 175GCT CAA GAA AAT CTA TCC CTT AAA AAT ATT TTT AAA ACC TTG AGT TCT 632Ala Gln Glu Asn Leu Ser Leu Lys Asn Ile Phe Lys Thr Leu Ser Ser
180 185 190AAA GAC GCT AAA GCC ATA GAA GAG TTG CAA GAC AAA CTG CGT TTT TCA 680Lys Asp Ala Lys Ala Ile Glu Glu Leu Gln Asp Lys Leu Arg Phe Ser195 200 205 210GCG CCA AAG TTG GGC GTT TCT ATC CAA GCG CAC CAT CTT AAA AAC CTT 728Ala Pro Lys Leu Gly Val Ser Ile Gln Ala His His Leu Lys Asn Leu
215 220 225TTG GAA GCC TTT TAT CAC CAA AAT AAA GAG AGT TTG GGC TTT TTT TCC 776Leu Glu Ala Phe Tyr His Gln Asn Lys Glu Ser Leu Gly Phe Phe Ser
230 235 240CCT TAT TTT AGT TTG CGA TCT CAA ACC CCT AGC GTC TCT TAT GAA AGC 824Pro Tyr Phe Ser Leu Arg Ser Gln Thr Pro Ser Val Ser Tyr Glu Ser
245 250 255GCG TTA GCT TCT TTA GAA AAC TAT TTT ATG GCT TTG TTC CAA TCC CAT 872Ala Leu Ala Ser Leu Glu Asn Tyr Phe Met Ala Leu Phe Gln Ser His
260 265 270TTT AAA GAC GAT ACC GCA CTC CAA CAG AAT TTT AAA GGA TTG TTG CAA 920Phe Lys Asp Asp Thr Ala Leu Gln Gln Asn Phe Lys Gly Leu Leu Gln275 280 285 290GCC TTT GTT TCT ATG GCT AAA GAC AAA CGA TCC CAA ATC GCT CTT AAC 968Ala Phe Val Ser Met Ala Lys Asp Lys Arg Ser Gln Ile Ala Leu Asn
295 300 305GCC CAA GCT AAA GAC AAC GCC AAG CTA ACT TTT AAC GCC TTG TTA GAA 1016Ala Gln Ala Lys Asp Asn Ala Lys Leu Thr Phe Asn Ala Leu Leu Glu
310 315 320AGC CTT AGC GTG AAT TTC TTT CAA TCT TAC AAA ATA AGC CAT GAG TGATT 1066Ser Leu Ser Val Asn Phe Phe Gln Ser Tyr Lys Ile Ser His Glu
325 330 335TCGAAGTCCC CCCCAAAGCT AAAGGGTTTA AACGCCTTTT TAAAGCCC 1114
(2) Sequence 406 data:
(i) sequence characteristics:
(A) length: 337 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 406: met Ser Trp Met Val Val Ile Gly Ala Leu Ile Cys Met Leu Leu Gly 151015 Val Phe Ile Phe Phe Thr Ser Met Ser Val Lys Lys Phe Leu Ser Ala
20 25 30Tyr Leu Asn Ala Tyr Leu Asp Gln Arg Pro His Ile Lys Gly Met Gly
35 40 45Ile Ala Gly Thr Pro Phe Glu Cys Glu Gly Phe Phe Lys Ile Ala Cys
50 55 60Val Ser Lys Glu Leu Ser Phe Leu Asp Ser Gln Asn Ser Pro Ile Val65 70 75 80Asn Phe Lys Asn Leu Ser Ile Lys Leu Arg Ser Leu Asp Lys Ser Ser
85 9095Leu Thr Leu Ser Val His Ser Gln Ile Lys Ser Pro Ile Leu Glu Gln
100 105 110Asp Met Gln Gln Lys Ile Ser Gln Ile Pro Leu Lys Asp Leu Asn Ala
115 120 125Leu Leu Glu Lys Met Lys Pro Thr Arg Leu Asn Cys Ser Leu Thr Phe
130 135 140Asn Ala Leu Asp Glu Lys Thr Leu Asn Asp Asn Leu Lys Cys Asp Leu145 150 155 160Thr Asn Ala Glu Asn Ile Leu Ala Tyr Thr Phe Phe Gln Glu Gly Leu
165 170 175Met Glu Ala Gln Glu Asn Leu Ser Leu Lys Asn Ile Phe Lys Thr Leu
180 185 190Ser Ser Lys Asp Ala Lys Ala Ile Glu Glu Leu Gln Asp Lys Leu Arg
195 200 205Phe Ser Ala Pro Lys Leu Gly Val Ser Ile Gln Ala His His Leu Lys
210 215 220Asn Leu Leu Glu Ala Phe Tyr His Gln Asn Lys Glu Ser Leu Gly Phe225 230 235 240Phe Ser Pro Tyr Phe Ser Leu Arg Ser Gln Thr Pro Ser Val Ser Tyr
245 250 255Glu Ser Ala Leu Ala Ser Leu Glu Asn Tyr Phe Met Ala Leu Phe Gln
260 265 270Ser His Phe Lys Asp Asp Thr Ala Leu Gln Gln Asn Phe Lys Gly Leu
275 280 285Leu Gln Ala Phe Val Ser Met Ala Lys Asp Lys Arg Ser Gln Ile Ala
290 295 300Leu Asn Ala Gln Ala Lys Asp Asn Ala Lys Leu Thr Phe Asn Ala Leu305 310 315 320Leu Glu Ser Leu Ser Val Asn Phe Phe Gln Ser Tyr Lys Ile Ser His
325 330 335Glu
(2) Sequence 407 data:
(i) sequence characteristics:
(A) length: 445bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...392
(D) Other information:
(xi) Description of the sequence: sequence 407: AAAATGAGGG TGTTTCAATT CAAGCCATGA GTAAGTTATA TGAGTAAGCC ATG AAT 56
Met Asn
1ATC AAA ACC CAT TCT TCA AAT GAA AAA GAA CGC TTT GTG CGC ATA GAA 104Ile Lys Thr His Ser Ser Asn Glu Lys Glu Arg Phe Val Arg Ile Glu
5 10 15GAG GAC GAA AAG AAA GGA TTA TTT GCT GGA ACT GCA AAT GAA AAT TCG 152Glu Asp Glu Lys Lys Gly Leu Phe Ala Gly Thr Ala Asn Glu Asn Ser
20 25 30CAC GGC CTT TCT TTA ATG GCT TTA ATA GGG GTA TTG GTT TTT GGG GGC 200His Gly Leu Ser Leu Met Ala Leu Ile Gly Val Leu Val Phe Gly Gly35 40 45 50GCG TTT TTA GCT CTG TTA GCG CCT AAA ATC TAT TTA AGC AAT AAT ATC 248Ala Phe Leu Ala Leu Leu Ala Pro Lys Ile Tyr Leu Ser Asn Asn Ile
5560 65TAT TAT ATT AGC CGT AAA ATC AAC ACC CTA GAA GAT CAA AAA CGC CTG 296Tyr Tyr Ile Ser Arg Lys Ile Asn Thr Leu Glu Asp Gln Lys Arg Leu
70 75 80CTT TTA GAA GAG CAA CAA ATC CTA AAA AAC GAA TTA GAA AAA GAG CGT 344Leu Leu Glu Glu Gln Gln Ile Leu Lys Asn Glu Leu Glu Lys Glu Arg
85 90 95TTT AAA TAC TAC ATA GAA AAT AGT GAA AAT ATT GGC GAT ATT GCG TTT T 393Phe Lys Tyr Tyr Ile Glu Asn Ser Glu Asn Ile Gly Asp Ile Ala Phe
100 105 110AAGTGAAAAA CCCCCTATCC CCTTAAGAGA GCTTAATTAA TGGTCAATCA TT 445
(2) Sequence 408 data:
(i) sequence characteristics:
(A) length: 114 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 408: met Asn Ile Lys Thr His Ser Ser Asn Glu Lys Glu Arg Phe Val Arg 151015 Ile Glu Glu Asp Glu Lys Lys Gly Leu Phe Ala Gly Thr Ala Asn Glu
20 25 30Asn Ser His Gly Leu Ser Leu Met Ala Leu Ile Gly Val Leu Val Phe
35 40 45Gly Gly Ala Phe Leu Ala Leu Leu Ala Pro Lys Ile Tyr Leu Ser Asn
50 55 60Asn Ile Tyr Tyr Ile Ser Arg Lys Ile Asn Thr Leu Glu Asp Gln Lys65 70 75 80Arg LeuLeu Leu Glu Glu Gln Gln Ile Leu Lys Asn Glu Leu Glu Lys
85 90 95Glu Arg Phe Lys Tyr Tyr Ile Glu Asn Ser Glu Asn Ile Gly Asp Ile
100 105 110Ala Phe
(2) Sequence 409 data:
(i) sequence characteristics:
(A) length: 218bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...165
(D) Other information:
(xi) Description of the sequence: sequence 409: AAGGTTTTTA GCGAAATAAG CCCCCACGCC AAACACGCCC ATGCTCATTA G CAC AAT 57
His Asn
1ATC GCA CAT AAA GCA CAA AGC GCA AAT CAA AAA CAC ATA ATT CCT AGC 105Ile Ala His Lys Ala Gln Ser Ala Asn Gln Lys His Ile Ile Pro Ser
5 10 15CAT CCC CCT TTC CAC AAT AAA CAA GGA TTG CGC CCC CAC CGC CGC ACA 153His Pro Pro Phe His Asn Lys Gln Gly Leu Arg Pro His Arg Arg Thr
20 25 30CAA AGA AAT CGC TAAACCAAAA CCTTCTATAA AAACCACAAA CATCTTGCTT AATCC 210Gln Arg Asn Arg35TTTCACTC 218
(2) Sequence 410 data:
(i) sequence characteristics:
(A) length: 38 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 410: his Asn Ile Ala His Lys Ala Gln Ser Ala Asn Gln Lys His Ile Ile 151015 Pro Ser His Pro Pro Phe His Asn Lys Gln Gly Leu Arg Pro His Arg
20 25 30Arg Thr Gln Arg Asn Arg
35
(2) Sequence 411 data:
(i) sequence characteristics:
(A) length: 967 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...914
(D) Other information:
(xi) Description of the sequence: sequence 411: TAGTCAAGTC GCTATTACTG CAAGCCCGGT GAGCGCAGCG GTNGGTGTTT ATG AGC 56
Met Ser
1GGC ATT TTA GAG CCT TTA GGA GCA AAT TAC TTG ACC CTT TTA ATG GTT 104Gly Ile Leu Glu Pro Leu Gly Ala Asn Tyr Leu Thr Leu Leu Met Val
5 10 15TGG ATC CCT ACG ACT TTT TTA GCA TGC ATG CTC ACG GCA TTT ATT ATG 152Trp Ile Pro Thr Thr Phe Leu Ala Cys Met Leu Thr Ala Phe Ile Met
20 25 30GGT TTT ACT GAT TTG AAA TTA GAC AGC GAT CCG CAT TAT TTA GAG CGC 200Gly Phe Thr Asp Leu Lys Leu Asp Ser Asp Pro His Tyr Leu Glu Arg35 40 45 50TTG AAA GCG GGC AAA ATC TCG CCC CCT AAA ATC AAA GAA GAA AAA GAA 248Leu Lys Ala Gly Lys Ile Ser Pro Pro Lys Ile Lys Glu Glu Lys Glu
55 60 65ACC TCA AAA AAC GCG AAA TTA TCG TTA TGG ATT TTT ATC GGT GGG GTT 296Thr Ser Lys Asn Ala Lys Leu Ser Leu Trp Ile Phe Ile Gly Gly Val
70 75 80GTA GCG ATC GTT TTT TAT GCG AGC GCG ATT TCT AAA AAT ATC GCT TTT 344Val Ala Ile Val Phe Tyr Ala Ser Ala Ile Ser Lys Asn Ile Ala Phe
85 90 95GTT AGC CCG GTG GTT TTA GGC AGA GAT CAC GCG ATT GTG TCT TTC ATG 392Val Ser Pro Val Val Leu Gly Arg Asp His Ala Ile Val Ser Phe Met
100 105 110CTA AGC GTG GCG ACT TTA ATT GTG CTT TTT TGC AAA ATT AAC GCT AAT 440Leu Ser Val Ala Thr Leu Ile Val Leu Phe Cys Lys Ile Asn Ala Asn115 120 125 130GAA ATC GCT CAT TCA AGC GTG TTT AAA TCC GGC ATG CAA GCG TGC GTG 488Glu Ile Ala His Ser Ser Val Phe Lys Ser Gly Met Gln Ala Cys Val
135 140 145TGC GTG TTG GGC GTG GCG TGG TTG GGC GAT ACT TTT GTG AGC AAT CAT 536Cys Val Leu Gly Val Ala Trp Leu Gly Asp Thr Phe Val Ser Asn His
150 155160ATA GAT GAG ATC AAA CGA TAC GCT TCT TTT TTG ATC GCA GAT TAT CCG 584Ile Asp Glu Ile Lys Arg Tyr Ala Ser Phe Leu Ile Ala Asp Tyr Pro
165 170 175TTT TTA TTA GCC GTA GCG CTC TTT TTG GCT TCC ATG CTT TTG TAT TCG 632Phe Leu Leu Ala Val Ala Leu Phe Leu Ala Ser Met Leu Leu Tyr Ser
180 185 190CAA GCC GCC ACC TCT AAA GCG CTC ATC CCA AGC GTG ATC ACA GCC TTA 680Gln Ala Ala Thr Ser Lys Ala Leu Ile Pro Ser Val Ile Thr Ala Leu195 200 205 210GGC ATT AGC GCT AAT CAT ACG GAG CAT TTG TAT ATT ATC GTG GCT TCG 728Gly Ile Ser Ala Asn His Thr Glu His Leu Tyr Ile Ile Val Ala Ser
215 220 225TTT GCG AGC GTT TCG GCG TTG TTT GTG TTA CCC ACT TAC CCC ACT TTA 776Phe Ala Ser Val Ser Ala Leu Phe Val Leu Pro Thr Tyr Pro Thr Leu
230 235 240CTA GGA GCG ATC GCT ATG GAT AAC ACC GGC ACC ACT AAA ATG GGC CGT 824Leu Gly Ala Ile Ala Met Asp Asn Thr Gly Thr Thr Lys Met Gly Arg
245 250 255TAT GTG TTT GAT CAT GCG TTT TTG ATC CCT GGG GTT TTA GTC GTG TCT 872Tyr Val Phe Asp His Ala Phe Leu Ile Pro Gly Val Leu Val Val Ser
260 265 270TTG AGC GTA GCG TTA GGG TTT GTT GTC GCG CCG TTA GTT TTG TAGATTTTA 923Leu Ser Val Ala Leu Gly Phe Val ValAla Pro Leu Val Leu275 280 285TCACCAACGA TAAAAAGCTT GGCGTTGCGA TTTTTCTAAA CCCC 967
(2) Sequence 412 data:
(i) sequence characteristics:
(A) length: 288 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 412: met Ser Gly Ile Leu Glu Pro Leu Gly Ala Asn Tyr Leu Thr Leu Leu 151015 Met Val Trp Ile Pro Thr Thr Phe Leu Ala Cys Met Leu Thr Ala Phe
20 25 30Ile Met Gly Phe Thr Asp Leu Lys Leu Asp Ser Asp Pro His Tyr Leu
35 40 45Glu Arg Leu Lys Ala Gly Lys Ile Ser Pro Pro Lys Ile Lys Glu Glu
50 55 60Lys Glu Thr Ser Lys Asn Ala Lys Leu Ser Leu Trp Ile Phe Ile Gly65 70 75 80Gly Val Val Ala Ile Val Phe Tyr Ala Ser Ala Ile Ser Lys Asn Ile
85 90 95Ala Phe Val Ser Pro Val Val Leu Gly Arg Asp His Ala Ile Val Ser
100 105 110Phe Met Leu Ser Val Ala Thr Leu Ile Val Leu Phe Cys Lys Ile Asn
115 120 125Ala Asn Glu Ile Ala His Ser Ser Val Phe Lys Ser Gly Met Gln Ala
130 135 140Cys Val Cys Val Leu Gly Val Ala Trp Leu Gly Asp Thr Phe Val Ser145 150 155 160Asn His Ile Asp Glu Ile Lys Arg Tyr Ala Ser Phe Leu Ile Ala Asp
165 170 175Tyr Pro Phe Leu Leu Ala Val Ala Leu Phe Leu Ala Ser Met Leu Leu
180 185 190Tyr Ser Gln Ala Ala Thr Ser Lys Ala Leu Ile Pro Ser Val Ile Thr
195 200 205Ala Leu Gly Ile Ser Ala Asn His Thr Glu His Leu Tyr Ile Ile Val
210 215 220Ala Ser Phe Ala Ser Val Ser Ala Leu Phe Val Leu Pro Thr Tyr Pro225 230 235 240Thr Leu Leu Gly Ala Ile Ala Met Asp Asn Thr Gly Thr Thr Lys Met
245 250 255Gly Arg Tyr Val Phe Asp His Ala Phe Leu Ile Pro Gly Val Leu Val
260 265 270Val Ser Leu Ser Val Ala Leu Gly Phe Val Val Ala Pro Leu Val Leu
275 280 285
(2) Sequence 413 data:
(i) sequence characteristics:
(A) length: 1237bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1184
(D) Other information:
(xi) Description of the sequence: sequence 413: AAAAATTCTA TCATTTTTGC GCGGTATTTT CATTTTAACA AGGAGCAAAA ATG CTA 56
Met Leu
1GAA AAT AGC TCT ATA TGG AGC AAT CCT GCC TTT GTG GCT ATC ATT TGC 104Glu Asn Ser Ser Ile Trp Ser Asn Pro Ala Phe Val Ala IleIle Cys
5 10 15ATG TGC GTT CTT AGC CTT TTA AGG CTC AAT GTC ATG CTT TCT ATG ATT 152Met Cys Val Leu Ser Leu Leu Arg Leu Asn Val Met Leu Ser Met Ile
20 25 30AGT GCG ACT CTC ATA GCA GGA CTT ATG GGA GGG CTT GGG ATC ACG GAG 200Ser Ala Thr Leu Ile Ala Gly Leu Met Gly Gly Leu Gly Ile Thr Glu35 40 45 50AGT TTT AAT GCA ATG ATA GAC GGC ATG AAA GGC AAT TTG AAC ATC GCT 248Ser Phe Asn Ala Met Ile Asp Gly Met Lys Gly Asn Leu Asn Ile Ala
55 60 65TTA AGC TAC ATC CTT TTA GGG GCT TTA GCG GTA GCG ATC GCT AAA AGC 296Leu Ser Tyr Ile Leu Leu Gly Ala Leu Ala Val Ala Ile Ala Lys Ser
70 75 80AAT CTC ATT AAA GTC GCT TTG AGT AAA TTA ATA GGT TTA ATG GAT TAC 344Asn Leu Ile Lys Val Ala Leu Ser Lys Leu Ile Gly Leu Met Asp Tyr
85 90 95AAG CGA TCC ACT TTT TGC TTT TTG ATC GCT TTC ATC GCA TGC TTT TCG 392Lys Arg Ser Thr Phe Cys Phe Leu Ile Ala Phe Ile Ala Cys Phe Ser
100 105 110CAA AAT TTA GTG CCG GTG CAT ATC GCT TTT ATC CCT ATT TTA ATC CCC 440Gln Asn Leu Val Pro Val His Ile Ala Phe Ile Pro IIe Leu Ile Pro115 120 125 130CCT CTT TTG CAT TTA ATG AAC CGG CTA GAA TTG GAT AGA AGA GCG GTC 488Pro Leu Leu His Leu Met Asn Arg Leu Glu Leu Asp Arg Arg Ala Val
135 140 145GCT TGC GCT TTA ACC TTT GGC TTG CAA GCC CCC TAC TTG GTG CTT CCT 536Ala Cys Ala Leu Thr Phe Gly Leu Gln Ala Pro Tyr Leu Val Leu Pro
150 155160GTA GGG TTT GGC TTG ATT TTT CAA ACC ACC ATT TTA GAG CAA TTA AAA 584Val Gly Phe Gly Leu Ile Phe Gln Thr Thr Ile Leu Glu Gln Leu Lys
165 170 175GCT AAT GGC GTT AGC ACC ACC ATA GCG CAA ATC ACA GGA GTG ATG TGG 632Ala Asn Gly Val Ser Thr Thr Ile Ala Gln Ile Thr Gly Val Met Trp
180 185 190ATA GCG GGG TTA GCG ATG GTC GTT GGA CTG CTT GTT GCT GTA TTA ACG 680Ile Ala Gly Leu Ala Met Val Val Gly Leu Leu Val Ala Val Leu Thr195 200 205 210CTA TAC AAA AAA CCC AGG CAC TAC AAA GAG AAA TCT TTT AAT ATA GAA 728Leu Tyr Lys Lys Pro Arg His Tyr Lys Glu Lys Ser Phe Asn Ile Glu
215 220 225AAT TAC GCC TCG CTT CAA TTA AAC TAC CAT GAC TAC TTG ACT TTT ATA 776Asn Tyr Ala Ser Leu Gln Leu Asn Tyr His Asp Tyr Leu Thr Phe Ile
230 235 240GGG ATT GTC GTA GCG TTT GTG ATC CAA TTA GCC ACC GAT TCG ATG CCC 824Gly Ile Val Val Ala Phe Val Ile Gln Leu Ala Thr Asp Ser Met Pro
245 250 255TTA GCC GCC TTT TTA GCG TTA GCG ATC ATC TTA TTA GGC CGT GGC ATT 872Leu Ala Ala Phe Leu Ala Leu Ala Ile Ile Leu Leu Gly Arg Gly Ile
260 265 270AAG TTT AAA GAA ACA GAC TCG CTT ATG GAT GAT AGC GTG AAA ATG ATG 920Lys Phe Lys Glu Thr Asp Ser Leu Met Asp Asp Ser Val Lys Met Met275 280 285 290GCG TTT ATC GCT TTT GTG ATG TTG GTG GCT AGC GGG TTT GGA GAA GTG 968Ala Phe Ile Ala Phe Val Met Leu Val Ala Ser Gly Phe Gly Glu Val
295 300 305TTG CAA AAA GTG CAT GCG ATA GAG GGC TTA GTG AAT GCG ATT ACA AGC 1016Leu GlnLys Val His Ala Ile Glu Gly Leu Val Asn Ala Ile Thr Ser
310 315 320GTA GTC CAA GGG AAG CTT TTA GGG GCT TTT TTA ATG CTT GTT GTA GGG 1064Val Val Gln Gly Lys Leu Leu Gly Ala Phe Leu Met Leu Val Val Gly
325 330 335CTT TTT ATC ACT ATG GGG ATA GGG ACT TCT TTT GGC ACT ATT CCT ATC 1112Leu Phe Ile Thr Met Gly Ile Gly Thr Ser Phe Gly Thr Ile Pro Ile
340 345 350ATC GCT GTG TTT TAT GTC CCT TTA TGC GCG AAA TTA GGT TTT AGC GTA 1160Ile Ala Val Phe Tyr Val Pro Leu Cys Ala Lys Leu Gly Phe Ser Val355 360 365 370GAA TCT ACG ATT TTA CTC ATC GCA TAGCCGCAGC TTTAGGCGAT GCAGGCTCAC 1214Glu Ser Thr Ile Leu Leu Ile Ala
375CGGCTAGCGA TAGCACCATG GGG 1237
(2) Sequence 414 data:
(i) sequence characteristics:
(A) length: 378 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 414: met Leu Glu Asn Ser Ser Ile Trp Ser Asn Pro Ala Phe Val Ala Ile 151015 Ile Cys Met Cys Val Leu Ser Leu Leu Arg Leu Asn Val Met Leu Ser
20 25 30Met Ile Ser Ala Thr Leu Ile Ala Gly Leu Met Gly Gly Leu Gly Ile
35 40 45Thr Glu Ser Phe Asn Ala Met Ile Asp Gly MetLys Gly Asn Leu Asn
50 55 60Ile Ala Leu Ser Tyr Ile Leu Leu Gly Ala Leu Ala Val Ala Ile Ala65 70 75 80Lys Ser Asn Leu Ile Lys Val Ala Leu Ser Lys Leu Ile Gly Leu Met
85 90 95Asp Tyr Lys Arg Ser Thr Phe Cys Phe Leu Ile Ala Phe Ile Ala Cys
100 105 110Phe Ser Gln Asn Leu Val Pro Val His Ile Ala Phe Ile Pro Ile Leu
115 120 125Ile Pro Pro Leu Leu His Leu Met Asn Arg Leu Glu Leu Asp Arg Arg
130 135 140Ala Val Ala Cys Ala Leu Thr Phe Gly Leu Gln Ala Pro Tyr Leu Val145 150 155 160Leu Pro Val Gly Phe Gly Leu Ile Phe Gln Thr Thr Ile Leu Glu Gln
165 170 175Leu Lys Ala Asn Gly Val Ser Thr Thr Ile Ala Gln Ile Thr Gly Val
180 185 190Met Trp Ile Ala Gly Leu Ala Met Val Val Gly Leu Leu Val Ala Val
195 200 205Leu Thr Leu Tyr Lys Lys Pro Arg His Tyr Lys Glu Lys Ser Phe Asn
210 215 220Ile Glu Asn Tyr Ala Ser Leu Gln Leu Asn Tyr His Asp Tyr Leu Thr225 230 235 240Phe Ile Gly Ile Val Val Ala Phe Val Ile Gln Leu Ala Thr Asp Ser
245 250 255Met Pro Leu Ala Ala Phe Leu Ala Leu Ala Ile Ile Leu Leu Gly Arg
260 265 270Gly Ile Lys Phe Lys Glu Thr Asp Ser LeuMet Asp Asp Ser Val Lys
275 280 285Met Met Ala Phe Ile Ala Phe Val Met Leu Val Ala Ser Gly Phe Gly
290 295 300Glu Val Leu Gln Lys Val His Ala Ile Glu Gly Leu Val Asn Ala Ile305 310 315 320Thr Ser Val Val Gln Gly Lys Leu Leu Gly Ala Phe Leu Met Leu Val
325 330 335Val Gly Leu Phe Ile Thr Met Gly Ile Gly Thr Ser Phe Gly Thr Ile
340 345 350Pro Ile Ile Ala Val Phe Tyr Val Pro Leu Cys Ala Lys Leu Gly Phe
355 360 365Ser Val Glu Ser Thr Ile Leu Leu Ile Ala
370 375
(2) Sequence 415 data:
(i) sequence characteristics:
(A) length: 945bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 61...636
(D) Other information:
(xi) Description of the sequence: sequence 415: TTAGCCACTA CCACAGGCAC AGGGTGTTCT TCATCAAATT TGAGAGCGAC GGCGTAATGG 60GTG GGG TTA GTA ACC ACG ACA TTG GCT TTA GGG ATT TCT TGC ATC ATT 108Val Gly Leu Val Thr Thr Thr Leu Ala Leu Gly Ile Ser Cys Ile Ile 151015 TTA TTC GTG GCG TTT TTT AGC ATC ATT TGG CGG ATT TTG GCT TTG ATT 156Leu Phe Val Ala PhePhe Ser Ile Ile Trp Arg Ile Leu Ala Leu Ile
20 25 30TCT GGG TTC CCT TCT TGC TGT TTG TAT TCG TCC TTA ACT TCT TGT TTA 204Ser Gly Phe Pro Ser Cys Cys Leu Tyr Ser Ser Leu Thr Ser Cys Leu
35 40 45GTC ATT TTT AAA GAG TTG GTG TAT TGG CGG CGT TTG ATC GCT AAA TCT 252Val Ile Phe Lys Glu Leu Val Tyr Trp Arg Arg Leu Ile Ala Lys Ser
50 55 60ATA AAA GCC AAG ACA AAA AAT AAA AAT AAA AGC GAA GAA ATG AGC CAT 300Ile Lys Ala Lys Thr Lys Asn Lys Asn Lys Ser Glu Glu Met Ser His65 70 75 80AAC GCC TTA TTT TTA AAC CAC AAC AAC TGG CCT TGT AAA TTC AAA AGA 348Asn Ala Leu Phe Leu Asn His Asn Asn Trp Pro Cys Lys Phe Lys Arg
85 90 95GCC GCA TGG TTT AAT TCC CCT AAA AAC AAA GAA AAG ATG AAA AAC CCC 396Ala Ala Trp Phe Asn Ser Pro Lys Asn Lys Glu Lys Met Lys Asn Pro
100 105 110AGA AAA AAA GCT AAA AAA ACT TTT AAG GTG ATC AAA CTC CCA TCA AGG 444Arg Lys Lys Ala Lys Lys Thr Phe Lys Val Ile Lys Leu Pro Ser Arg
115 120 125AGC TTT TTT AAA GAA AAA AGG TTT TTG ACG CCA TTG ATA GGG TTG ATT 492Ser Phe Phe Lys Glu Lys Arg Phe Leu Thr Pro Leu Ile Gly Leu Ile
130 135 140TTA GAA AAT TTA GGC TCA ATG ACT TTA GGG GCA AAG AGC CAG CCA AAT 540Leu Glu Asn Leu Gly Ser Met Thr Leu Gly Ala Lys Ser Gln Pro Asn145 150 155 160TGC AAG ACA TTA GAT AAA AAC GCC ACC ACC ACT AAA ATG ATT AAA ATC 588Cys Lys Thr Leu Asp Lys Asn Ala Thr Thr Thr Lys Met Ile Lys Ile
165 170175GGT AAA AGC AAT AAA AAA GTG TCT TTA GCC AGT TGG TTA AAC AGC TCT T 637Gly Lys Ser Asn Lys Lys Val Ser Leu Ala Ser Trp Leu Asn Ser Ser
180 185 190GAACGCTTTC TTTACTGAAA TCTAGGGAAA AATCTTTCAA CACATGGCGA TACATTTCGC 697TAAAGCCATC CACCCACCAT ATAAAAAAAA CAAAAATACT AATTAGCCCG GCCAATAACC 757CCAAAACCCC CACCACTTCC ATGCTCTTAG GCACATTGCC TTCTTCTCTG GCTTTTTGGA 817TTTTTTTCGC GCTAGGGAGT TCGGTTTTTT CTTCTTCAGC CATTGGCCCT CTTTTTTAAA 877ATTTGAACGG CTAATTCATA GTCTTTTAGG GTGTTTAGGT TTAAAAATTC TTCTTCTTTG 937TCAAAATT 945
(2) Sequence 416 data:
(i) sequence characteristics:
(A) length: 192 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 416: val Gly Leu Val Thr Thr Thr Leu Ala Leu Gly Ile Ser Cys Ile Ile 151015 Leu Phe Val Ala Phe Phe Ser lle Ile Trp Arg Ile Leu Ala Leu Ile
20 25 30Ser Gly Phe Pro Ser Cys Cys Leu Tyr Ser Ser Leu Thr Ser Cys Leu
35 40 45Val Ile Phe Lys Glu Leu Val Tyr Trp Arg Arg Leu Ile Ala Lys Ser
50 55 60Ile Lys Ala Lys Thr Lys Asn Lys Asn Lys Ser Glu Glu Met Ser His65 70 75 80Asn Ala Leu Phe Leu Asn His Asn Asn Trp Pro Cys Lys Phe Lys Arg
8590 95Ala Ala Trp Phe Asn Ser Pro Lys Asn Lys Glu Lys Met Lys Asn Pro
100 105 110Arg Lys Lys Ala Lys Lys Thr Phe Lys Val Ile Lys Leu Pro Ser Arg
115 120 125Ser Phe Phe Lys Glu Lys Arg Phe Leu Thr Pro Leu Ile Gly Leu Ile
130 135 140Leu Glu Asn Leu Gly Ser Met Thr Leu Gly Ala Lys Ser Gln Pro Ash145 150 155 160Cys Lys Thr Leu Asp Lys Asn Ala Thr Thr Thr Lys Met Ile Lys Ile
165 170 175Gly Lys Ser Asn Lys Lys Val Ser Leu Ala Ser Trp Leu Asn Ser Ser
180 185 190
(2) Sequence 417 data:
(i) sequence characteristics:
(A) length: 851bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...783
(D) Other information:
(xi) Description of the sequence: sequence 417: ATTGATAGTT TCTTCAGCAA GAATGATTAG GCAATGATTA GGTTGTAG ATG AAT TTT 57
Met Asn Phe
1TAT CAA AAA ATA TAC ACT CAT AAA GTC GTT TTT TCT TCA TTG TTTTTT 105Tyr Gln Lys Ile Tyr Thr His Lys Val Val Phe Ser Ser Leu Phe Phe
5 10 15TTG TTG TTT TTG TTC AAT GTG GAA ACT TTG TTG CTT TCG CAT TTC AGC 153Leu Leu Phe Leu Phe Asn Val Glu Thr Leu Leu Leu Ser His Phe Ser20 25 30 35GAT GAT TTT TCG CAA TTG TTT TTT TTG TTT GAA AAC CAT GTT TAT GAT 201Asp Asp Phe Ser Gln Leu Phe Phe Leu Phe Glu Asn His Val Tyr Asp
40 45 50TTC ATT GTC AAA TTA GAT TAT TTG GGG CTA ATA GGC GTT TCT TTA ATT 249Phe Ile Val Lys Leu Asp Tyr Leu Gly Leu Ile Gly Val Ser Leu Ile
55 60 65TAT CTG CTT GTG CTT ATT CTA AAG CCT TTC ACC CTC ACG CGC CAA AAA 297Tyr Leu Leu Val Leu Ile Leu Lys Pro Phe Thr Leu Thr Arg Gln Lys
70 75 80TGC GCT TGC GTA GGG ATA TTA TGC CTT TCT TTC TAC GCT TGG AAT TTT 345Cys Ala Cys Val Gly Ile Leu Cys Leu Ser Phe Tyr Ala Trp Asn Phe
85 90 95CCT GTT AAA GAT TCT TTA ATG GTG CTT TAT CTT TTC TAT TTT GCG CTG 393Pro Val Lys Asp Ser Leu Met Val Leu Tyr Leu Phe Tyr Phe Ala Leu100 105 110 115TTA GCG ACT TTA TTG TGG CGT TTT TTA GGG GCT AGC ATG AAG CAA TCT 441Leu Ala Thr Leu Leu Trp Arg Phe Leu Gly Ala Ser Met Lys Gln Ser
120 125 130TTC TTG CCC TCT ATG AAT ATT TGC ATC GTG TGG GTT TTT GCT TCT TCT 489Phe Leu Pro Ser Met Asn Ile Cys Ile Val Trp Val Phe Ala Ser Ser
135 140 145TTA CAG AGT TTT AGG TTT TTA AGC GTG TCT GAT TGC GTG GAT TTT TCC 537Leu Gln Ser Phe Arg Phe Leu Ser Val Ser Asp Cys Val Asp Phe Ser
150 155 160CTT TTT ACA CTC GCG CTT ATT TTA TTG ATA CTG GTT TTA ATC TAT TGC 585Leu Phe Thr Leu Ala Leu Ile Leu Leu Ile Leu Val Leu Ile Tyr Cys
165 170 175AAA CGC CTT TTT GGG TTG TAT GAA TAC GCT AAC ACG CTC ATT TTG ATC 633Lys Arg Leu Phe Gly Leu Tyr Glu Tyr Ala Asn Thr Leu Ile Leu Ile180 l85 190 195GTG GGG CTT AGC GTG GTG GTG CTA TGC TCT AGC ATG TTC ATT CAA ACT 681Val Gly Leu Ser Val Val Val Leu Cys Ser Ser Met Phe Ile Gln Thr
200 205 210AAA GAA TAC TAT GGC ATG CGA TTG GGT TTT TAT TTT TTA GGC CTG TTA 729Lys Glu Tyr Tyr Gly Met Arg Leu Gly Phe Tyr Phe Leu Gly Leu Leu
215 220 225GGG TGG CTT TTA GAA TAT GTG CAT AAC ACT TTA AGG CGT TTG GAA CAT 777Gly Trp Leu Leu Glu Tyr Val His Asn Thr Leu Arg Arg Leu Glu His
230 235 240CAA ATT TAAAGCTCAA ATAGGAATAG CTAAAGCCTT TTGATTGAGT GTTTTTTTAG GG 835Gln Ile
245CTTAAAAGCG GGTTTA 85l
(2) Sequence 418 data:
(i) sequence characteristics:
(A) length: 245 amino acid
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 418: met Asn Phe Tyr Gln Lys Ile Tyr Thr His Lys Val Val Phe Ser Ser 151015 Leu Phe Phe Leu Leu Phe Leu Phe Asn Val Glu Thr Leu Leu Leu Ser
20 25 30His Phe Ser Asp Asp Phe Ser Gln Leu Phe Phe Leu Phe Glu Asn His
35 40 45Val Tyr Asp Phe Ile Val Lys Leu Asp Tyr Leu Gly Leu Ile Gly Val
50 55 60Ser Leu Ile Tyr Leu Leu Val Leu Ile Leu Lys Pro Phe Thr Leu Thr65 70 75 80Arg Gln Lys Cys Ala Cys Val Gly Ile Leu Cys Leu Ser Phe Tyr Ala
85 90 95Trp Asn Phe Pro Val Lys Asp Ser Leu Met Val Leu Tyr Leu Phe Tyr
100 105 110Phe Ala Leu Leu Ala Thr Leu Leu Trp Arg Phe Leu Gly Ala Ser Met
115 120 125Lys Gln Ser Phe Leu Pro Ser Met Asn Ile Cys Ile Val Trp Val Phe
130 135 140Ala Ser Ser Leu Gln Ser Phe Arg Phe Leu Ser Val Ser Asp Cys Val145 150 155 160Asp Phe Ser Leu Phe Thr Leu Ala Leu Ile Leu Leu Ile Leu Val Leu
165 170 175Ile Tyr Cys Lys Arg Leu Phe Gly Leu Tyr Glu Tyr Ala Asn Thr Leu
180 185 190Ile Leu Ile Val Gly Leu Ser Val Val Val Leu Cys Ser Ser Met Phe
195 200 205Ile Gln Thr Lys Glu Tyr Tyr Gly Met Arg Leu Gly Phe Tyr Phe Leu
210 215 220Gly Leu Leu Gly Trp Leu Leu Glu Tyr Val His Asn Thr Leu Arg Arg225 230 235 240Leu Glu His Gln Ile
245
(2) Sequence 419 data:
(i) sequence characteristics:
(A) length: 827bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 95...745
(D) Other information:
(xi) Description of the sequence: sequence 419: CTTTTTACTT TTAGTTAAGT TGTAAGAAAC TTTAGCTACC ATGCGATACA AAAAAGGATT 60TTAAGTGCGT TTTGGTAAAA TTGATTATTT GAAC ATG CTC CCT TTT GAT GTG TTT 115
Met Leu Pro Phe Asp Val Phe
1 5ATC AAA TCC TAC CCC ACC CCT TGT TAT TTC AAA CAA TTC TTA CGG CTT 163Ile Lys Ser Tyr Pro Thr Pro Cys Tyr Phe Lys Gln Phe Leu Arg Leu
10 15 20AAA AAA ACC TAC CCC TCC AAA CTC AAT GAG AGT TTT TTA TTC AGG CGT 211Lys Lys Thr Tyr Pro Ser Lys Leu Asn Glu Ser Phe Leu Phe Arg Arg
25 30 35ATT GAT GCG GGG TTT ATT TCT TCT ATC GCC GGC TAT CCA TTC GCT CTT 259Ile Asp Ala Gly Phe Ile Ser Ser Ile Ala Gly Tyr Pro Phe Ala Leu40 45 50 55CAT TCC CAT TCT CTA GGC ATT GTC GCT TAT AAG GAA GTT TTA AGC GTG 307His Ser His Ser Leu Gly Ile Val Ala Tyr Lys Glu Val Leu Ser Val
6065 70CTG GTT GTG GAT ACA AAA AAC GCT TTT GAT AAA GAA AGC GCT TCT TCA 355Leu Val Val Asp Thr Lys Asn Ala Phe Asp Lys Glu Ser Ala Ser Ser
75 80 85AAC GCC CTC TCT CAA GCG CTA GGG TTA AAG GGC GAA GTG TTA ATC GGC 403Asn Ala Leu Ser Gln Ala Leu Gly Leu Lys Gly Glu Val Leu Ile Gly
90 95 100AAT AAA GCA CTG CAG TTT TAT TAT TCC AAC CCT AAA AAA GAT TTT ATA 451Asn Lys Ala Leu Gln Phe Tyr Tyr Ser Asn Pro Lys Lys Asp Phe Ile
105 110 115GAT TTA GCC GCT CTT TGG TAT GAA AAA AAA CGC TTG CCG TTT GTT TTT 499Asp Leu Ala Ala Leu Trp Tyr Glu Lys Lys Arg Leu Pro Phe Val Phe120 125 130 135GGG CGT TTG TGT TAT TAC CAA AAC AAG GAT TTT TAC AAG CGC TTG TCT 547Gly Arg Leu Cys Tyr Tyr Gln Asn Lys Asp Phe Tyr Lys Arg Leu Ser
140 145 150TTA GCT TTC AAA CAT CAA AAA ACA AAA ATC CCT TAC TAC ATC CTT AAA 595Leu Ala Phe Lys His Gln Lys Thr Lys Ile Pro Tyr Tyr Ile Leu Lys
155 160 165GAA GCC GCT TTA AAA ACC AAC TTA AAA CGC CAA GAT ATT TTA AAT TAC 643Glu Ala Ala Leu Lys Thr Asn Leu Lys Arg Gln Asp Ile Leu Asn Tyr
170 175 180TTG CAA AAA ATT TAC TAC ACT TTA GGC AAA AAG GAG CAA TTA GGT CTT 691Leu Gln Lys Ile Tyr Tyr Thr Leu Gly Lys Lys Glu Gln Leu Gly Leu
185 190 195AAA GCG TTC TAT CGT GAA TTG TTA TTC AAA CGC ATT CAA AAA CCC AAG 739Lys Ala Phe Tyr Arg Glu Leu Leu Phe Lys Arg Ile Gln Lys Pro Lys200 205 210 215CGT TTT TAGTGATTCG CTGAGAATGT AGGCTTAAAA TTCAGAAAGG GTGTTTTTAA GC 797Arg PheAAGATTAGGT TACAATCACA AGTTTTATTA 827
(2) Sequence 420 data:
(i) sequence characteristics:
(A) length: 217 amino acid
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 420: met Leu Pro Phe Asp Val Phe Ile Lys Ser Tyr Pro Thr Pro Cys Tyr 151015 Phe Lys Gln Phe Leu Arg Leu Lys Lys Thr Tyr Pro Ser Lys Leu Asn
20 25 30Glu Ser Phe Leu Phe Arg Arg Ile Asp Ala Gly Phe Ile Ser Ser Ile
35 40 45Ala Gly Tyr Pro Phe Ala Leu His Ser His Ser Leu Gly Ile Val Ala
50 55 60Tyr Lys Glu Val Leu Ser Val Leu Val Val Asp Thr Lys Asn Ala Phe65 70 75 80Asp Lys Glu Ser Ala Ser Ser Asn Ala Leu Ser Gln Ala Leu Gly Leu
85 90 95Lys Gly Glu Val Leu Ile Gly Asn Lys Ala Leu Gln Phe Tyr Tyr Ser
100 105 110Asn Pro Lys Lys Asp Phe Ile Asp Leu Ala Ala Leu Trp Tyr Glu Lys
115 120 125Lys Arg Leu Pro Phe Val Phe Gly Arg Leu Cys Tyr Tyr Gln Asn Lys
130 135 140Asp Phe Tyr Lys Arg Leu Ser Leu Ala Phe Lys His Gln Lys Thr Lys145 150 155160Ile Pro Tyr Tyr Ile Leu Lys Glu Ala Ala Leu Lys Thr Asn Leu Lys
165 170 175Arg Gln Asp Ile Leu Asn Tyr Leu Gln Lys Ile Tyr Tyr Thr Leu Gly
180 185 190Lys Lys Glu Gln Leu Gly Leu Lys Ala Phe Tyr Arg Glu Leu Leu Phe
195 200 205Lys Arg Ile Gln Lys Pro Lys Arg Phe
210 215
(2) Sequence 421 data:
(i) sequence characteristics:
(A) length: 736bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 76...663
(D) Other information:
(xi) Description of the sequence: sequence 421: GCAACAAGAA ATTTTAGAGA AAATGAGACC CAACGCTCAA AAAATTCAAG CGGGTTAAAC 60GGCTAAAAAG GAGAG ATG ATG GGA TAC ATT CCT TAT GTA ATA GAG AAT ACC 111
Met Met Gly Tyr Ile Pro Tyr Val Ile Glu Asn Thr
1 5 10GAT CGT GGG GAG CGT AGC TAT GAT ATT TAC TCG CGC CTT TTA AAG GAT 159Asp Arg Gly Glu Arg Ser Tyr Asp Ile Tyr Ser Arg Leu Leu Lys Asp
15 20 25CGC ATT GTT TTA TTG AGC GGT GAA ATT AAT GAC AGC GTG GCG TCT TCT 207Arg Ile Val Leu Leu Ser Gly Glu Ile Asn Asp SerVal Ala Ser Ser
30 35 40ATC GTG GCC CAA CTC TTG TTT TTG GAA GCT GAA GAC CCT GAA AAA GAC 255Tle Val Ala Gln Leu Leu Phe Leu Glu Ala Glu Asp Pro Glu Lys Asp45 50 55 60ATT GGT TTG TAT ATC AAT TCT CCC GGT GGG GTG ATA ACA AGC GGT CTT 303Ile Gly Leu Tyr Ile Asn Ser Pro Gly Gly Val Ile Thr Ser Gly Leu
65 70 75AGT ATT TAT GAC ACC ATG AAT TTT ATC CGC CCT GAT GTT TCC ACG ATT 351Ser Ile Tyr Asp Thr Met Asn Phe Ile Arg Pro Asp Val Ser Thr Ile
80 85 90TGC ATC GGT CAA GCG GCT TCT ATG GGG GCG TTT TTA CTG AGC TGT GGG 399Cys Ile Gly Gln Ala Ala Ser Met Gly Ala Phe Leu Leu Ser Cys Gly
95 100 105GCT AAG GGC AAG CGC TTT TCG CTA CCC CAT TCA AGG ATT ATG ATC CAC 447Ala Lys Gly Lys Arg Phe Ser Leu Pro His Ser Arg Ile Met Ile His
110 115 120CAG CCT TTA GGG GGG GCT CAA GGG CAA GCG AGC GAT ATT GAA ATC ATT 495Gln Pro Leu Gly Gly Ala Gln Gly Gln Ala Ser Asp Ile Glu Ile Ile125 130 135 140TCT AAT GAG ATT CTC AGG CTT AAA GGC TTG ATG AAT TCT ATT CTA GCT 543Ser Asn Glu Ile Leu Arg Leu Lys Gly Leu Met Asn Ser Ile Leu Ala
145 150 155CAA AAC TCA GGG CAG AGT TTG GAG CAA ATC GCT AAA GAC ACG GAC AGG 591Gln Asn Ser Gly Gln Ser Leu Glu Gln Ile Ala Lys Asp Thr Asp Arg
160 165 170GAT TTT TAT ATG AGT GCT AAA GAA GCT AAA GAG TAT GGC TTG ATT GAT 639Asp Phe Tyr Met Ser Ala Lys Glu Ala Lys Glu Tyr Gly Leu Ile Asp
175 180185AAA GTG TTA CAG AAA AAC GTG AAG TGATTGCATG GCGTTATTAG AGATTATCCA 693Lys Val Leu Gln Lys Asn Val Lys
190 195TTACCCTTCT AAAATCTTAA GAACGATTTC TAAAGAGGTC GTT 736
(2) Sequence 422 data:
(i) sequence characteristics:
(A) length: 196 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 422: met Met Gly Tyr Ile Pro Tyr Val Ile Glu Asn Thr Asp Arg Gly Glu 151015 Arg Ser Tyr Asp Ile Tyr Ser Arg Leu Leu Lys Asp Arg Ile Val Leu
20 25 30Leu Ser Gly Glu Ile Asn Asp Ser Val Ala Ser Ser Ile Val Ala Gln
35 40 45Leu Leu Phe Leu Glu Ala Glu Asp Pro Glu Lys Asp Ile Gly Leu Tyr
50 55 60Ile Asn Ser Pro Gly Gly Val Ile Thr Ser Gly Leu Ser Ile Tyr Asp65 70 75 80Thr Met Asn Phe Ile Arg Pro Asp Val Ser Thr Ile Cys Ile Gly Gln
85 90 95Ala Ala Ser Met Gly Ala Phe Leu Leu Ser Cys Gly Ala Lys Gly Lys
100 105 110Arg Phe Ser Leu Pro His Ser Arg Ile Met Ile His Gln Pro Leu Gly
115 120 125Gly Ala Gln Gly Gln Ala Ser Asp Ile Glu Ile Ile Ser Asn Glu Ile
130 135 140Leu Arg Leu Lys Gly Leu Met Asn Ser Ile Leu Ala Gln Asn Ser Gly145 150 155 160Gln Ser Leu Glu Gln Ile Ala Lys Asp Thr Asp Arg Asp Phe Tyr Met
165 170 175Ser Ala Lys Glu Ala Lys Glu Tyr Gly Leu Ile Asp Lys Val Leu Gln
180 185 190Lys Asn Val Lys
195
(2) Sequence 423 data:
(i) sequence characteristics:
(A) length: 904bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...852
(D) Other information:
(xi) Description of the sequence: sequence 423: CGC ATA AAA AAA GAA CGC TTG AAC AAA CTG CTT AAA AGG GGG TTT TTA 48Arg Ile Lys Lys Glu Arg Leu Asn Lys Leu Leu Lys Arg Gly Phe Leu 151015 GCG TTC TTT TTG AGC GTG TAT TTA AGG GCT GAT GAT TTG GTT ACT TAC 96Ala Phe Phe Leu Ser Val Tyr Leu Arg Ala Asp Asp Leu Val Thr Tyr
20 25 30ACC ATC ATC AAA GAA AAA GAT CTA GGA TAC CAG CGG TTT TTA GCC AAG 144Thr Ile Ile Lys Glu Lys Asp Leu Gly Tyr Gln Arg Phe Leu Ala Lys
35 40 45AAG TGT TTA AGG GGT AAA ACC CAC CCT CCG TGT TTT ACT AAG CCT AAA 192Lys Cys Leu Arg Gly Lys Thr His Pro Pro Cys Phe Thr Lys Pro Lys
50 55 60AAG CCT AAA AGA AAA CTT TTT AAT ATA GAC AAA AGC TCC CAC TAT TAT 240Lys Pro Lys Arg Lys Leu Phe Asn Ile Asp Lys Ser Ser His Tyr Tyr65 70 75 80GGC ACA AGC GTG GTG CAA ATG TCA TGG CTA CAG AGT AGG GAA AAA TTT 288Gly Thr Ser Val Val Gln Met Ser Trp Leu Gln Ser Arg Glu Lys Phe
85 90 95GAA AAC CAT TCA AAA TAC CGA GAC ATT CCT TTT GCT GAA GTC AGT TTG 336Glu Asn His Ser Lys Tyr Arg Asp Ile Pro Phe Ala Glu Val Ser Leu
100 105 110ATT TAT GGC TAT AAA CAA TTT TTT CCT AAA AAA GAG CGC TAC GGC TTC 384Ile Tyr Gly Tyr Lys Gln Phe Phe Pro Lys Lys Glu Arg Tyr Gly Phe
115 120 125CGT TTT TAT GTC TCT TTG GAT TAC GCT TAT GGG TTT TTT CTT AAA AAT 432Arg Phe Tyr Val Ser Leu Asp Tyr Ala Tyr Gly Phe Phe Leu Lys Asn
130 135 140AAG GGC GTG TTG GGC GAT AGT TTG AGG GAG AGT TCG CAA ATC CCT AAA 480Lys Gly Val Leu Gly Asp Ser Leu Arg Glu Ser Ser Gln Ile Pro Lys145 150 155 160AGC TAT AGA GAA AAA TTG CAA AGA AAA GAG ACT TTT ATT AAC GCT ATT 528Ser Tyr Arg Glu Lys Leu Gln Arg Lys Glu Thr Phe Ile Asn Ala Ile
165 170 175TTT TAT GGC GCG GGA GCT GAC TTT TTA TAC AAA CGC GCT TTT GGA ACG 576Phe Tyr Gly Ala Gly Ala Asp Phe Leu Tyr Lys Arg Ala Phe Gly Thr
180 185 190CTG ATT TTA GGG ATG AAT TTC GTG GGA GAA ACC TGG TTT TAT GAA ACA 624Leu Ile Leu Gly Met Asn Phe Val Gly Glu Thr Trp Phe Tyr Glu Thr
195 200 205AAG ATT TTT AAA AAG TGG GCT AAA GAT CCT TTG AGC GTT TAT CAC CCT 672Lys Ile Phe Lys Lys Trp Ala Lys Asp Pro Leu Ser Val Tyr His Pro
210 215 220TAC ATG TTT CAA GTG ATG TTG AAT GTG GGG TAT CGT TAC CGC TTT TCA 720Tyr Met Phe Gln Val Met Leu Asn Val Gly Tyr Arg Tyr Arg Phe Ser225 230 235 240AGG TAT AAG AAT TGG GCG ATA GAA TTG GGT GCG CGC ATC CCT TTT TTA 768Arg Tyr Lys Asn Trp Ala Ile Glu Leu Gly Ala Arg Ile Pro Phe Leu
245 250 255ACC AAT GAT TAT TTT AAA ACC CCT TTA TAC ACC CTT CAT TTC AAG CGC 816Thr Asn Asp Tyr Phe Lys Thr Pro Leu Tyr Thr Leu His Phe Lys Arg
260 265 270AAT ATT TCT GTC TAT CTC ACT TCA ACT TAT GAC TTT TAGTTTTTTA AATTTT 868Asn Ile Ser Val Tyr Leu Thr Ser Thr Tyr Asp Phe
275 280TGAAAACTAG AATTAAAACC GCTTTTTATA AACTGG 904
(2) Sequence 424 data:
(i) sequence characteristics:
(A) length: 284 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 424: arg Ile Lys Lys Glu Arg Leu Asn Lys Leu Leu Lys Arg Gly Phe Leu 151015 Ala Phe Phe Leu Ser Val Tyr Leu Arg Ala Asp Asp Leu Val Thr Tyr
20 25 30Thr Ile Ile Lys Glu Lys Asp Leu Gly Tyr Gln Arg Phe Leu Ala Lys
35 40 45Lys Cys Leu Arg Gly Lys Thr His Pro Pro Cys Phe Thr Lys Pro Lys
50 55 60Lys Pro Lys Arg Lys Leu Phe Asn Ile Asp Lys Ser Ser His Tyr Tyr65 70 75 80Gly Thr Ser Val Val Gln Met Ser Trp Leu Gln Ser Arg Glu Lys Phe
85 90 95Glu Asn His Ser Lys Tyr Arg Asp Ile Pro Phe Ala Glu Val Ser Leu
100 105 110Ile Tyr Gly Tyr Lys Gln Phe Phe Pro Lys Lys Glu Arg Tyr Gly Phe
115 120 125Arg Phe Tyr Val Ser Leu Asp Tyr Ala Tyr Gly Phe Phe Leu Lys Asn
130 135 140Lys Gly Val Leu Gly Asp Ser Leu Arg Glu Ser Ser Gln Ile Pro Lys145 150 155 160Ser Tyr Arg Glu Lys Leu Gln Arg Lys Glu Thr Phe Ile Asn Ala Ile
165 170 175Phe Tyr Gly Ala Gly Ala Asp Phe Leu Tyr Lys Arg Ala Phe Gly Thr
180 185 190Leu Ile Leu Gly Met Asn Phe Val Gly Glu Thr Trp Phe Tyr Glu Thr
195 200 205Lys Ile Phe Lys Lys Trp Ala Lys Asp Pro Leu Ser Val Tyr His Pro
210 215 220Tyr Met Phe Gln Val Met Leu Asn Val Gly Tyr Arg Tyr Arg Phe Ser225 230 235 240Arg Tyr Lys Asn Trp Ala Ile Glu Leu Gly Ala Arg Ile Pro Phe Leu
245 250 255Thr Asn Asp Tyr Phe Lys Thr Pro Leu TyrThr Leu His Phe Lys Arg
260 265 270Asn Ile Ser Val Tyr Leu Thr Ser Thr Tyr Asp Phe
275 280
(2) Sequence 425 data:
(i) sequence characteristics:
(A) length: 1172bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 75...1106
(D) Other information:
(xi) Description of the sequence: sequence 425: TAATCGTTAT TAAACATGCT ATATTTCTTT TTTCTATAAA ACTCAATATT ATTGAATAAA 60ACTAGGGAGT TAGA ATG ATC TTA AAA CGA GTT ACT GAA GCT TTA GAA GCG 110
Met Ile Leu Lys Arg Val Thr Glu Ala Leu Glu Ala
1 5 10TAT AAA AAT GGC GAA ATG CTC ATT GTT ATG GAC GAT GAA GAC AGA GAA 158Tyr Lys Asn Gly Glu Met Leu Tle Val Met Asp Asp Glu Asp Arg Glu
15 20 25AAT GAG GGG GAT TTG GTT TTA GCT GGG ATT TTT TCT ACC CCT GAG AAA 206Asn Glu Gly Asp Leu Val Leu Ala Gly Ile Phe Ser Thr Pro Glu Lys
30 35 40ATC AAT TTC ATG GCC ACG CAT GCT AGG GGG TTG ATT TGC GTG TCT TTG 254Ile Asn Phe Met Ala Thr His Ala Arg Gly Leu Ile Cys Val Ser Leu45 50 55 60ACC AAA GAT TTA GCG AAA AAA TTT GAA TTA CCC CCT ATG GTT AGC GTG 302Thr Lys Asp Leu Ala Lys Lys Phe Glu Leu Pro Pro Met Val Ser Val
65 70 75AAT GAT TCT AAC CAT GAG ACC GCT TTC ACG GTT TCC ATT GAC GCT AAA 350Asn Asp Ser Asn His Glu Thr Ala Phe Thr Val Ser Ile Asp Ala Lys
80 85 90GAA GCC AGA ACC GGG ATT TCT GCT TTT GAA AGG CAT TTA ACG ATT GAA 398Glu Ala Arg Thr Gly Ile Ser Ala Phe Glu Arg His Leu Thr Ile Glu
95 100 105TTA TTG TGT AAA GAC ACC ACC AAA CCG AGC GAT TTT GTG CGC CCG GGG 446Leu Leu Cys Lys Asp Thr Thr Lys Pro Ser Asp Phe Val Arg Pro Gly
110 115 120CAT ATT TTC CCT TTG ATC GCC AAA GAC GGG GGC GTG TTA GCG CGC ACG 494His Ile Phe Pro Leu Ile Ala Lys Asp Gly Gly Val Leu Ala Arg Thr125 130 135 140GGC CAT ACT GAA GCG AGC GTG GAT TTG TGC AAA TTA GCT GGA TTA AAG 542Gly His Thr Glu Ala Ser Val Asp Leu Cys Lys Leu Ala Gly Leu Lys
145 150 155CCC GTG AGC GTG ATT TGT GAA ATC ATG AAA GAA GAT GGC TCT ATG GCG 590Pro Val Ser Val Ile Cys Glu Ile Met Lys Glu Asp Gly Ser Met Ala
160 165 170AGA AGG GGG GAT AAA TTT TTG AGC GAT TTC GCC CTC AAA CAT AAC CTT 638Arg Arg Gly Asp Lys Phe Leu Ser Asp Phe Ala Leu Lys His Asn Leu
175 180 185AAA ACT CTC TAT GTC TCT GAT TTG ATT AGC TAT CGT TTG GAA AAT GAA 686Lys Thr Leu Tyr Val Ser Asp Leu Ile Ser Tyr Arg Leu Glu Asn Glu
190 195 200AGT TTG CTG AAA ATG TTT TGT CAA GAA GAA AGG GAA TTT TTA AAA CAC 734Ser Leu Leu Lys Met Phe Cys Gln Glu Glu Arg Glu Phe Leu Lys His205 210 215 220CAA ACG CAA TGC TAC ACT TTT TTA GAT CAC CAG CAA AAA AAC CAT TAC 782Gln Thr Gln Cys Tyr Thr Phe Leu Asp His Gln Gln Lys Asn His Tyr
225 230 235GCT TTT AAG TTT AAA GGC GCA AAA ACC CAT GAT TTA GCC CCT TTA GTG 830Ala Phe Lys Phe Lys Gly Ala Lys Thr His Asp Leu Ala Pro Leu Val
240 245 250CGT TTC CAC CCT ATC AAA GAG GAT TTT GAT TTT TTA ACG ACT GAT GCG 878Arg Phe His Pro Ile Lys Glu Asp Phe Asp Phe Leu Thr Thr Asp Ala
255 260 265TTT GAA GTG TTT TTT AAA GCG TTA GAA TAT TTA AAG CAC GAA GGG GGC 926Phe Glu Val Phe Phe Lys Ala Leu Glu Tyr Leu Lys His Glu Gly Gly
270 275 280TAT TTG ATC TTT ATG AAC ACC CAT TCT AAA GAA AAC AAT GTC GTT AAA 974Tyr Leu Ile Phe Met Asn Thr His Ser Lys Glu Asn Asn Val Val Lys285 290 295 300GAT TTT GGG ATC GGG GCG TTG GTG TTA AAA AAT TTG GGG ATA AAG GAT 1022Asp Phe Gly Ile Gly Ala Leu Val Leu Lys Asn Leu Gly Ile Lys Asp
305 310 315TTC AGG CTC TTA AGC TCT TGT GAA GAC AGG CAG TAT AAG GCT TTG AGC 1070Phe Arg Leu Leu Ser Ser Cys Glu Asp Arg Gln Tyr Lys Ala Leu Ser
320 325 330GGG TTT GGG CTT AAG CTT GTA GAA ACG ATT AGC CTT TAAGAGGCTC GTTAAG 1122Gly Phe Gly Leu Lys Leu Val Glu Thr Ile Ser Leu
335 340TTTTATTGAA TGTGTTGTAA TGTTTTTAAG GTATAATAAA CTCTTTTTAA 1172
(2) Sequence 426 data:
(i) sequence characteristics:
(A) length: 344 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 426: met Ile Leu Lys Arg Val Thr Glu Ala Leu Glu Ala Tyr Lys Asn Gly 151015 Glu Met Leu Ile Val Met Asp Asp Glu Asp Arg Glu Asn Glu Gly Asp
20 25 30Leu Val Leu Ala Gly Ile Phe Ser Thr Pro Glu Lys Ile Asn Phe Met
35 40 45Ala Thr His Ala Arg Gly Leu Ile Cys Val Ser Leu Thr Lys Asp Leu
50 55 60Ala Lys Lys Phe Glu Leu Pro Pro Met Val Ser Val Asn Asp Ser Asn65 70 75 80His Glu Thr Ala Phe Thr Val Ser Ile Asp Ala Lys Glu Ala Arg Thr
85 90 95Gly Ile Ser Ala Phe Glu Arg His Leu Thr Ile Glu Leu Leu Cys Lys
100 105 110Asp Thr Thr Lys Pro Ser Asp Phe Val Arg Pro Gly His Ile Phe Pro
115 120 125Leu Ile Ala Lys Asp Gly Gly Val Leu Ala Arg Thr Gly His Thr Glu
130 135 140Ala Ser Val Asp Leu Cys Lys Leu Ala Gly Leu Lys Pro Val Ser Val145 150 155 160Ile Cys Glu Ile Met Lys Glu Asp Gly Ser Met Ala Arg Arg Gly Asp
165 170 175Lys Phe Leu Ser Asp Phe AlaLeu Lys His Asn Leu Lys Thr Leu Tyr
180 185 190Val Ser Asp Leu Ile Ser Tyr Arg Leu Glu Asn Glu Ser Leu Leu Lys
195 200 205Met Phe Cys Gln Glu Glu Arg Glu Phe Leu Lys His Gln Thr Gln Cys
210 215 220Tyr Thr Phe Leu Asp His Gln Gln Lys Asn His Tyr Ala Phe Lys Phe225 230 235 240Lys Gly Ala Lys Thr His Asp Leu Ala Pro Leu Val Arg Phe His Pro
245 250 255Ile Lys Glu Asp Phe Asp Phe Leu Thr Thr Asp Ala Phe Glu Val Phe
260 265 270Phe Lys Ala Leu Glu Tyr Leu Lys His Glu Gly Gly Tyr Leu Ile Phe
275 280 285Met Asn Thr His Ser Lys Glu Asn Asn Val Val Lys Asp Phe Gly Ile
290 295 300Gly Ala Leu Val Leu Lys Asn Leu Gly Ile Lys Asp Phe Arg Leu Leu305 310 315 320Ser Ser Cys Glu Asp Arg Gln Tyr Lys Ala Leu Ser Gly Phe Gly Leu
325 330 335Lys Leu Val Glu Thr Ile Ser Leu
340
(2) Sequence 427 data:
(i) sequence characteristics:
(A) length: 394bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...341
(D) Other information:
(xi) Description of the sequence: sequence 427: GATTTATCCT TGCATAAAAC AATCTCGCTT GGCGATAAAA AACGCTCTAA AAA CTT 56
Lys Leu
1CAT TTT AAA GCG TTT CAC GCA CTT TTC TAT CCT AGC AAT AGA GAC AAT 104His Phe Lys Ala Phe His Ala Leu Phe Tyr Pro Ser Asn Arg Asp Asn
5 10 15ATC TAT GCC AAT CAT TTA AAA TTA TTG GAT AAT GAA ATC AGT GAA AAA 152Ile Tyr Ala Asn His Leu Lys Leu Leu Asp Asn Glu Ile Ser Glu Lys
20 25 30GAC ATT TTT AAT AAA GCC ATC AAT CAA AAA CGA ATT CAA ATG GCT CTT 200Asp Ile Phe Asn Lys Ala Ile Asn Gln Lys Arg Ile Gln Met Ala Leu35 40 45 50AAT CTC ATC TTT AAG CTT GTT TTT GCC TTT GTT AGT AAC CAC TTC TTC 248Asn Leu Ile Phe Lys Leu Val Phe Ala Phe Val Ser Asn His Phe Phe
55 60 65CAC GCT TTT AGA CGA CAG AAT CTC TAT AAT CGT GTC TTT AAT CGC TGT 296His Ala Phe Arg Arg Gln Asn Leu Tyr Asn Arg Val Phe Asn Arg Cys
70 75 80GTC TTT AAC CTT GAC TTC ATT CAA AAG CTT TTC ATT ACT CAA TTC TAACG 346Val Phe Asn Leu Asp Phe Ile Gln Lys Leu Phe Ile Thr Gln Phe
85 90 95AAATAGAAGC CTTAAGGTAG CGTCTGCCAT TTTGAGAGAC CAGATTCA 394
(2) Sequence 428 data:
(i) sequence characteristics:
(A) length: 97 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 428: lys Leu His Phe Lys Ala Phe His Ala Leu Phe Tyr Pro Ser Asn Arg 151015 Asp Asn Ile Tyr Ala Asn His Leu Lys Leu Leu Asp Asn Glu Ile Ser
20 25 30Glu Lys Asp Ile Phe Asn Lys Ala Ile Asn Gln Lys Arg Ile Gln Met
35 40 45Ala Leu Asn Leu Ile Phe Lys Leu Val Phe Ala Phe Val Ser Asn His
50 55 60Phe Phe His Ala Phe Arg Arg Gln Asn Leu Tyr Asn Arg Val Phe Asn65 70 75 80Arg Cys Val Phe Asn Leu Asp Phe Ile Gln Lys Leu Phe Ile Thr Gln
85 90 95Phe
(2) Sequence 429 data:
(i) sequence characteristics:
(A) length: 360bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 82...270
(D) Other information:
(xi) Description of the sequence: sequence 429ACTTAAAGGC ATAAAAACCT TAAGCTTTTT GAGTTTCAAA AGGGTTTCAA GCTTTTTATA 60AGACTTTTTT TGAATGAGTA A GGA GAA AAT ATT TTG TTC CAT AAA CTG ATC 111
Gly Glu Asn Ile Leu Phe His Lys Leu Ile
1 5 10TTA ACA TGC TTT TTA GCG CTTGTA GCA ATA ACC ATT CAA GCTTGC GGT 159Leu Thr Cys Phe Leu Ala Leu Val Ala Ile Thr Ile Gln Ala Cys Gly
15 20 25TAT AAA GCC CCT CCA TTC AAT GAA AAA CCC GCT AAA AAA ACT TCA AAC 207Tyr Lys Ala Pro Pro Phe Asn Glu Lys Pro Ala Lys Lys Thr Ser Asn
30 35 40AGC TCT AAT TCT TCT ATG CAA ACG CCC ACC AAC AGC ACC ACG CCA GAA 255Ser Ser Asn Ser Ser Met Gln Thr Pro Thr Asn Ser Thr Thr Pro Glu
45 50 55TTT TTA AAT CAG CCT TAAAATCACT GCTCTTGTTT AAGGGCTTTG ATTTCTAGGG T 311Phe Leu Asn Gln Pro
60TTTTGTGGCT AACTTTTGAN STTCGCTTTC ATCATGCGTT ACCATAATG 360
(2) Sequence 430 data:
(i) sequence characteristics:
(A) length: 63 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 430: gly Glu Asn Ile Leu Phe His Lys Leu Ile Leu Thr Cys Phe Leu Ala 151015 Leu Val Ala Ile Thr Ile Gln Ala Cys Gly Tyr Lys Ala Pro Pro Phe
2025 30Asn Glu Lys Pro Ala Lys Lys Thr Ser Asn Ser Ser Asn Ser Ser Met
35 40 45Gln Thr Pro Thr Asn Ser Thr Thr Pro Glu Phe Leu Asn Gln Pro
50 55 60
(2) Sequence 431 data:
(i) sequence characteristics:
(A) length: 445bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...392
(D) Other information:
(xi) Description of the sequence: sequence 431: ATTTACAAAG CGTGTTGGAT ACCCCCAAGA TGATTCGTTT GGAAAATTGA ATG CGC 56
Met Arg
1TTT TTG AAC AAC AAA CAT AGA GAA AAG GGC TTA AAG GCT GAA GAA GAA 104Phe Leu Asn Asn Lys His Arg Glu Lys Gly Leu Lys Ala Glu Glu Glu
5 10 15GCT TGC GGA TTT TTA AAA TCG TTA GGT TTT GAA ATG GTG GAG AGG AAC 152Ala Cys Gly Phe Leu Lys Ser Leu Gly Phe Glu Met Val Glu Arg Asn
20 25 30TTT TTT TCA CAA TTT GGC GAA ATT GAT ATT ATC GCT TTG AAA AAA GGG 200Phe Phe Ser Gln Phe Gly Glu Ile Asp Ile Ile Ala Leu Lys Lys Gly35 40 45 50GTT TTG CAT TTC ATT GAA GTC AAA AGC GGG GAA AAT TTT GAT CCC ATT 248Val Leu His Phe Ile Glu Val Lys Ser Gly Glu Asn Phe Asp Pro Ile
55 60 65TAT GCG ATC ACG CCG AGC AAA TTA AAA AAG ATG ATT AAA ACG ATC CGC 296Tyr Ala Ile Thr Pro Ser Lys Leu Lys Lys Met Ile Lys Thr Ile Arg
70 75 80TGT TAT TTG TCC CAA AAA GAT CCC AAT AGC GAT TTT TGC ATA GAC GCT 344Cys Tyr Leu Ser Gln Lys Asp Pro Asn Ser Asp Phe Cys Ile Asp Ala
85 90 95CTT ATT GTG AAA AAT GGT AAA TTT GAG CTT TTA GAA AAT ATC ACT TTT T 393Leu Ile Val Lys Asn Gly Lys Phe Glu Leu Leu Glu Asn Ile Thr Phe
100 105 110AGATTTTTAC AGAAAGTAAA TGCGATTTCA TTAACATTCT TAAGCTAATA TA 445
(2) Sequence 432 data:
(i) sequence characteristics:
(A) length: 114 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 432: met Arg Phe Leu Asn Asn Lys His Arg Glu Lys Gly Leu Lys Ala Glu 151015 Glu Glu Ala Cys Gly Phe Leu Lys Ser Leu Gly Phe Glu Met Val Glu
20 25 30Arg Asn Phe Phe Ser Gln Phe Gly Glu Ile Asp Ile Ile Ala Leu Lys
35 40 45Lys Gly Val Leu His Phe Ile Glu Val Lys Ser Gly Glu Asn Phe Asp
50 55 60Pro Ile Tyr Ala Ile Thr Pro Ser Lys Leu Lys Lys Met Ile Lys Thr65 70 75 80Ile Arg Cys Tyr Leu Ser Gln Lys Asp Pro Asn Ser Asp Phe Cys Ile
85 90 95Asp Ala Leu Ile Val Lys Asn Gly Lys Phe Glu Leu Leu Glu Asn Ile
100 105 110Thr Phe
(2) Sequence 433 data:
(i) sequence characteristics:
(A) length: 831bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic RNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 86...763
(D) Other information:
(xi) Description of the sequence: sequence 433: CGTTAAAAAG CTTGGTTTAA TGAGTTTTTA AAACTTAATT GCTACAATTA AGGAAATTTT 60CAATAAGGCT TAGAGAAACT TTTTC ATG GAA CAC AGA GTA TTT ACT ATT GCT 112
Met Glu His Arg Val Phe Thr Ile Ala
1 5AAT TTT TTT AGC TCC AAT CAT GAT TTT ATC ACC GGG TTT TTT GTC GTT 160Asn Phe Phe Ser Ser Asn His Asp Phe Ile Thr Gly Phe Phe Val Val10 15 20 25TTG ACA GCG GTT TTG ATG TTT TTA ATC TCG CTT GGC GCG TCG CGC AAA 208Leu Thr Ala Val Leu Met Phe Leu Ile Ser Leu Gly Ala Ser Arg Lys
30 35 40ATG CAG ATG GTA CCT ATG GGT TTG CAG AAT GTG TAT GAG AGC ATC ATT 256Met Gln Met Val Pro Met Gly Leu Gln Asn Val Tyr Glu Ser Ile Ile
45 50 55AGC GCG ATT TTG AGC GTG GCT AAG GAT ATT ATA GGC GAA GAA TTA GCC 304Ser Ala Ile Leu Ser Val Ala Lys Asp Ile Ile Gly Glu Glu Leu Ala
60 65 70CGC AAA TAC TTC CCC CTA GCT GGC ACG ATC GCT TTG TAT GTC TTT TTT 352Arg Lys Tyr Phe Pro Leu Ala Gly Thr Ile Ala Leu Tyr Val Phe Phe
75 80 85TCT AAC ATG ATA GGC ATC ATT CCT GGC TTT GAA TCC CCT ACG GCT AGC 400Ser Asn Met Ile Gly Ile Ile Pro Gly Phe Glu Ser Pro Thr Ala Ser90 95 100 105TGG AGC TTT ACG CTG GTT TTA GCG CTG ATT GTG TTT TTT TAT TAC CAT 448Trp Ser Phe Thr Leu Val Leu Ala Leu Ile Val Phe Phe Tyr Tyr His
110 115 120TTT GAA GGC ATT AGA GTG CAG GGC TTT TTT AAG TAT TTC GCT CAT TTT 496Phe Glu Gly Ile Arg Val Gln Gly Phe Phe Lys Tyr Phe Ala His Phe
125 130 135GCA GGT CCT GTG AAA TGG CTC GCC CCT TTC ATG TTC CCT ATT GAG ATC 544Ala Gly Pro Val Lys Trp Leu Ala Pro Phe Met Phe Pro Ile Glu Ile
140 145 150ATC TCG CAT TTT TCT AGG ATC GTG TCT TTA TCG TTT CGT TTG TTT GGG 592Ile Ser His Phe Ser Arg Ile Val Ser Leu Ser Phe Arg Leu Phe Gly
155 160 165AAT ATC AAG GGC GAT GAC ATG TTC TTG CTC ATC ATG CTT TTA TTA GTG 640Asn Ile Lys Gly Asp Asp Met Phe Leu Leu Ile Met Leu Leu Leu Val170 175 180 185CCT TGG GCG GTT CCT GTA GCG CCT TTT ATG GTG TTG TTT TTC ATG GGG 688Pro Trp Ala Val Pro Val Ala Pro Phe Met Val Leu Phe Phe Met Gly
190 195 200ATT TTA CAA GCT TTT GTT TTT ATG ATC CTC ACT TAT GTG TAT TTG GCA 736Ile Leu Gln Ala Phe Val Phe Met Ile Leu Thr Tyr Val Tyr Leu Ala
205 210 215GGG GCT GTT TTA ACC GAT GAA GGG CAT TAAGCAATAA CATTCTTGTT TGGCTTT 790Gly Ala Val Leu Thr Asp Glu Gly His
220 225AATATTGTTT TTTAAAACTT TGTTTTATGG TAAAGCTTTT A 831
(2) Sequence 434 data:
(i) sequence characteristics:
(A) length: 226 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 434: met Glu His Arg Val Phe Thr Ile Ala Asn Phe Phe Ser Ser Asn His 151015 Asp Phe Ile Thr Gly Phe Phe Val Val Leu Thr Ala Val Leu Met Phe
20 25 30Leu Ile Ser Leu Gly Ala Ser Arg Lys Met Gln Met Val Pro Met Gly
35 40 45Leu Gln Asn Val Tyr Glu Ser Ile Ile Ser Ala Ile Leu Ser Val Ala
50 55 60Lys Asp Ile Ile Gly Glu Glu Leu Ala Arg Lys Tyr Phe Pro Leu Ala65 70 75 80Gly Thr Ile Ala Leu Tyr Val Phe Phe Ser Asn Met Ile Gly Ile Ile
85 90 95Pro Gly PheGlu Ser Pro Thr Ala Ser Trp Ser Phe Thr Leu Val Leu
100 105 110Ala Leu Ile Val Phe Phe Tyr Tyr His Phe Glu Gly Ile Arg Val Gln
115 120 125Gly Phe Phe Lys Tyr Phe Ala His Phe Ala Gly Pro Val Lys Trp Leu
130 135 140Ala Pro Phe Met Phe Pro Ile Glu Ile Ile Ser His Phe Ser Arg Ile145 150 155 160Val Ser Leu Ser Phe Arg Leu Phe Gly Asn Ile Lys Gly Asp Asp Met
165 170 175Phe Leu Leu Ile Met Leu Leu Leu Val Pro Trp Ala Val Pro Val Ala
180 185 190Pro Phe Met Val Leu Phe Phe Met Gly Ile Leu Gln Ala Phe Val Phe
195 200 205Met Ile Leu Thr Tyr Val Tyr Leu Ala Gly Ala Val Leu Thr Asp Glu
210 215 220Gly His225
(2) Sequence 435 data:
(i) sequence characteristics:
(A) length: 787bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...734
(D) Other information:
(xi) Description of the sequence: sequence 435: AGCCATAATA ACAACCAATG GCTAGAGCCT GATGATTTGT TGAAATTATT ATG AAT 56
Met Asn
1TTT TTA GAA GAT TTG TTT TAC CCC TTA AGA TTG TTA GAA AAC AAG CGT 104Phe Leu Glu Asp Leu Phe Tyr Pro Leu Arg Leu Leu Glu Asn Lys Arg
5 10 15GTT TTA TTG CTC GTG AGC GGT TCT ATT GCA GCG TAT AAA TCC CTA GAA 152Val Leu Leu Leu Val Ser Gly Ser Ile Ala Ala Tyr Lys Ser Leu Glu
20 25 30TTA GTG CGC TTG TTG TTT AAA AGC GGG GCT AGT ATC CAA GTG GTG ATG 200Leu Val Arg Leu Leu Phe Lys Ser Gly Ala Ser Ile Gln Val Val Met35 40 45 50AGT AAG GGT GCG AAA AAA TTC ATC AAA CCC TTA AGT TTT GAA GCT TTG 248Ser Lys Gly Ala Lys Lys Phe Ile Lys Pro Leu Ser Phe Glu Ala Leu
55 60 65AGC CAC CAT AAA GTC TTG CAT GAT CGT AAT GAA AAA TGG TAT TAC AAC 296Ser His His Lys Val Leu His Asp Arg Asn Glu Lys Trp Tyr Tyr Asn
70 75 80CAC CAA AAC GCC TTA CAC CAT AAC CAC ATC GCA TGC GCT GCT AAT GCT 344His Gln Asn Ala Leu His His Asn His Ile Ala Cys Ala Ala Asn Ala
85 90 95GAT TTG CTC ATC TTT GCC CCT TTA AGC ACT AAC AGC TTG TCT AAA ATC 392Asp Leu Leu Ile Phe Ala Pro Leu Ser Thr Asn Ser Leu Ser Lys Ile
100 105 110GCT CAC GCT TTA GCG GAT AAT ATC GTA AGC GCG ACT TTT TTA GCT TGC 440Ala His Ala Leu Ala Asp Asn Ile Val Ser Ala Thr Phe Leu Ala Cys115 120 125 130GCT TCC CCT AAA ATC CTA GCC CCT AGC ATG AAC ACT AAC ATG CTC AAT 488Ala Ser Pro Lys Ile Leu Ala Pro Ser Met Asn Thr Asn Met Leu Asn
135 140 145TCC CCT ATC ACT CAA AGT AAT TTA AAA CGC TTG AAA GAT TCC AAC CAC 536Ser Pro Ile Thr Gln Ser Asn Leu Lys Arg Leu Lys Asp Ser Asn His
150 155 160ATT ATT TTA GAC ACC AAA AAC GCC CTT TTA GCA TGC GAC ACT AAA GGC 584Ile Ile Leu Asp Thr Lys Asn Ala Leu Leu Ala Cys Asp Thr Lys Gly
165 170 175GAT GGG GCG ATG GCT GAG CCT TTA GAA ATC CTT TTT AAA GCC GCT CAA 632Asp Gly Ala Met Ala Glu Pro Leu Glu Ile Leu Phe Lys Ala Ala Gln
180 185 190ACG CTC CTA AAA GAC GCT TAT TTT GAA AAC AGA GAA GTC ATA GTC ATG 680Thr Leu Leu Lys Asp Ala Tyr Phe Glu Asn Arg Glu Val Ile Val Met195 200 205 210GGC GGC GCG AGT ATA GAA AAG ATT GAC AGC GTT CGA ACG ATT AGC AAT 728Gly Gly Ala Ser Ile Glu Lys Ile Asp Ser Val Arg Thr Ile Ser Asn
215 220 225ACT TTC TAGCGGGATT CAAGCGAGCG CTTTAGCTTT GGCGTTATAT TTTAAGGGAG CC 786Thr PheA 787
(2) Sequence 436:
(i) sequence characteristics:
(A) length: 228 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 436: met Asn Phe Leu Glu Asp Leu Phe Tyr Pro Leu Arg Leu Leu Glu Asn 151015 Lys Arg Val Leu Leu Leu Val Ser Gly Ser Ile Ala Ala Tyr Lys Ser
20 25 30Leu Glu Leu Val Arg Leu Leu Phe Lys Ser Gly Ala Ser Ile Gln Val
35 40 45Val Met Ser Lys Gly Ala Lys Lys Phe Ile Lys Pro Leu Ser Phe Glu
50 55 60Ala Leu Ser His His Lys Val Leu His Asp Arg Asn Glu Lys Trp Tyr65 70 75 80Tyr Asn His Gln Asn Ala Leu His His Asn His Ile Ala Cys Ala Ala
85 90 95Asn Ala Asp Leu Leu Ile Phe Ala Pro Leu Ser Thr Asn Ser Leu Ser
100 105 110Lys Ile Ala His Ala Leu Ala Asp Asn Ile Val Ser Ala Thr Phe Leu
115 120 125Ala Cys Ala Ser Pro Lys Ile Leu Ala Pro Ser Met Asn Thr Asn Met
130 135 140Leu Asn Ser Pro Ile Thr Gln Ser Asn Leu Lys Arg Leu Lys Asp Ser145 150 155 160Asn His Ile Ile Leu Asp Thr Lys Asn Ala Leu Leu Ala Cys Asp Thr
165 170 175Lys Gly Asp Gly Ala Met Ala Glu Pro Leu Glu Ile Leu Phe Lys Ala
180 185 190Ala Gln Thr Leu Leu Lys Asp Ala Tyr Phe Glu Asn Arg Glu Val Ile
195 200 205Val Met Gly Gly Ala Ser Ile Glu Lys Ile Asp Ser Val Arg Thr Ile
210 215 220Ser Asn Thr Phe225
(2) Sequence 437 data:
(i) sequence characteristics:
(A) length: 1078bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 71...1009
(D) Other information:
(xi) Description of the sequence: sequence 437: TCCCAAGCCC TAAAGGCGCT TCAATCATTG ATTTTAAAGG CAGTTATGAA GAGTATTTGG 60CGAGCAAAAA ATG AAA CCG CAA GAC ATT GAA ATC GTT CAA AGC GTT TTA 109
Met Lys Pro Gln Asp Ile Glu Ile Val Gln Ser Val Leu
1 5 10GAG ATT ACA GGA CCG ATT AAG CCT ACT GAA GTG TAT GAT AAA GCC AAA 157Glu Ile Thr Gly Pro Ile Lys Pro Thr Glu Val Tyr Asp Lys Ala Lys
15 20 25GAG CTT TTT GAA AAA GGT GAG ATT ACA AAC ATG TTT GAT TGT GGG GGC 205Glu Leu Phe Glu Lys Gly Glu Ile Thr Asn Met Phe Asp Cys Gly Gly30 35 40 45AAA ACC CCG CAC CAG AGC GTT AGT TCT TAT ATT TAT ACA GCC TTA AAC 253Lys Thr Pro His Gln Ser Val Ser Ser Tyr Ile Tyr Thr Ala Leu Asn
50 55 60AAG GGC GAA GAA CTG CCT TTT AAA AAA GTG CAA GAA AAC CCA ACC TTA 301Lys Gly Glu Glu Leu Pro Phe Lys Lys Val Gln Glu Asn Pro Thr Leu
65 70 75ATC GCT TTA AAA GAC GCG GCT AAA GAG CTA GGT TTA GAC GCT CAA AAA 349Ile Ala Leu Lys Asp Ala Ala Lys Glu Leu Gly Leu Asp Ala Gln Lys
80 8590ATA AGC GCT CCA AGC TCT AAA ATC GCG CAT GAA AGG GAT TTG CAC CCC 397Ile Ser Ala Pro Ser Ser Lys Ile Ala His Glu Arg Asp Leu His Pro
95 100 105TTT TTA ACC TAC ATG GCT ATT AAT AAC GAA AAT TTG AAA TGC TAC ACG 445Phe Leu Thr Tyr Met Ala Ile Asn Asn Glu Asn Leu Lys Cys Tyr Thr110 115 120 125AAA ACC ATT TTT CAT GAA GAG AGT TCA AAA TCA ATA AAA GGC ATG GAC 493Lys Thr Ile Phe His Glu Glu Ser Ser Lys Ser Ile Lys Gly Met Asp
130 135 140AGG TGG CTT TAT CCG GAC ATG GTG GGG GTT AGG TTT TTG CAC GCT GAA 541Arg Trp Leu Tyr Pro Asp Met Val Gly Val Arg Phe Leu His Ala Glu
145 150 155TTA TCT AAT GAA AAT TTA ATC GCT TTT TCT AAG AAA TTT GAC ACT TTA 589Leu Ser Asn Glu Asn Leu Ile Ala Phe Ser Lys Lys Phe Asp Thr Leu
160 165 170CCC ATT AAA CTG GTG AGC TTT GAA TTG AAA AAA GAA ATC AGC GTG CAT 637Pro Ile Lys Leu Val Ser Phe Glu Leu Lys Lys Glu Ile Ser Val His
175 180 185AAT TGC AGG GAG TGT TAC TTT CAA GCG ATT TCC AAC AGC TCG TGG GCT 685Asn Cys Arg Glu Cys Tyr Phe Gln Ala Ile Ser Asn Ser Ser Trp Ala190 195 200 205AAT GAA GGG TAT TTA GTG GGC CGT CAT ATT GAT ACG CAC AAT CCT CAA 733Asn Glu Gly Tyr Leu Val Gly Arg His Ile Asp Thr His Asn Pro Gln
210 215 220CTC ATG GAT TTG TTG AAG CGT TTG CAT GCG AGT TTT GGG ATT GGC GTG 781Leu Met Asp Leu Leu Lys Arg Leu His Ala Ser Phe Gly Ile Gly Val
225 230 235ATT GAT TTA AGA ACT AAT GAG GAT AAA AGC GCT ATT TTA TTG AACGCT 829Ile Asp Leu Arg Thr Asn Glu Asp Lys Ser Ala Ile Leu Leu Asn Ala
240 245 250AAA TAC AAA GAA AAG ATT GAT TAC ACC GTG GCT TCA GAG CTT AGC GCG 877Lys Tyr Lys Glu Lys Ile Asp Tyr Thr Val Ala Ser Glu Leu Ser Ala
255 260 265AAA AAT GAA AAA TTC AGC GGT TTT TTA AAG AGC GTT GTG GAT TAT GAC 925Lys Asn Glu Lys Phe Ser Gly Phe Leu Lys Ser Val Val Asp Tyr Asp270 275 280 285CCA AAC CAC CCA CAA CGC TAT AAA GAT GAA TTT GAT GAG GTT AAA AAG 973Pro Asn His Pro Gln Arg Tyr Lys Asp Glu Phe Asp Glu Val Lys Lys
290 295 300AAA GAG GAG TTA TAC CCT AAC CCA TCG CTT TCT TTT TAAAAATGAG ATTTTA 1025Lys Glu Glu Leu Tyr Pro Asn Pro Ser Leu Ser Phe
305 310AAAAACGCTT TAAGTGTTTT TGTAAAAAAT AGCAAAGAGC TTGATTTTAA TCA 1078
(2) Sequence 438 data:
(i) sequence characteristics:
(A) length: 313 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 438: met Lys Pro Gln Asp Ile Glu Ile Val Gln Ser Val Leu Glu Ile Thr 151015 Gly Pro Ile Lys Pro Thr Glu Val Tyr Asp Lys Ala Lys Glu Leu Phe
20 25 30Glu Lys Gly Glu Ile Thr Asn Met Phe Asp Cys Gly Gly Lys Thr Pro
35 4045His Gln Ser Val Ser Ser Tyr Ile Tyr Thr Ala Leu Asn Lys Gly Glu
50 55 60Glu Leu Pro Phe Lys Lys Val Gln Glu Asn Pro Thr Leu Ile Ala Leu65 70 75 80Lys Asp Ala Ala Lys Glu Leu Gly Leu Asp Ala Gln Lys Ile Ser Ala
85 90 95Pro Ser Ser Lys Ile Ala His Glu Arg Asp Leu His Pro Phe Leu Thr
100 105 110Tyr Met Ala Ile Asn Asn Glu Asn Leu Lys Cys Tyr Thr Lys Thr Ile
115 120 125Phe His Glu Glu Ser Ser Lys Ser Ile Lys Gly Met Asp Arg Trp Leu
130 135 140Tyr Pro Asp Met Val Gly Val Arg Phe Leu His Ala Glu Leu Ser Asn145 150 155 160Glu Asn Leu Ile Ala Phe Ser Lys Lys Phe Asp Thr Leu Pro Ile Lys
165 170 175Leu Val Ser Phe Glu Leu Lys Lys Glu Ile Ser Val His Asn Cys Arg
180 185 190Glu Cys Tyr Phe Gln Ala Ile Ser Asn Ser Ser Trp Ala Asn Glu Gly
195 200 205Tyr Leu Val Gly Arg His Ile Asp Thr His Asn Pro Gln Leu Met Asp
210 215 220Leu Leu Lys Arg Leu His Ala Ser Phe Gly Ile Gly Val Ile Asp Leu225 230 235 240Arg Thr Asn Glu Asp Lys Ser Ala Ile Leu Leu Asn Ala Lys Tyr Lys
245 250 255Glu Lys Ile Asp Tyr Thr Val Ala Ser Glu Leu Ser Ala Lys Asn Glu
260 265 270LysPhe Ser Gly Phe Leu Lys Ser Val Val Asp Tyr Asp Pro Asn His
275 280 285Pro Gln Arg Tyr Lys Asp Glu Phe Asp Glu Val Lys Lys Lys Glu Glu
290 295 300Leu Tyr Pro Asn Pro Ser Leu Ser Phe305 310
(2) Sequence 439 data:
(i) sequence characteristics:
(A) length: 444bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 112...375
(D) Other information:
(xi) Description of the sequence: sequence 439: AACTCGCCTT AGGCGCGATG GCGTTTAAGG AAGTCAAGCT TTTTGAATTT GGCGAGCAAT 60TAAGGGATTT TGTACTATAT TGAAGATGTG ATCCAAGCGA GCGTGAAAGC G ATG AAG 117
Met Lys
1GCT CAA AAA AGC GGG GTT TAT AAT GTG GGT TAT TCC CAA GCC AGA AGT 165Ala Gln Lys Ser Gly Val Tyr Asn Val Gly Tyr Ser Gln Ala Arg Ser
5 10 15TAT AAT GAA ATC GTT AGC ATT TTA AAA GAG CAT TTA GGG GAT TTT AAA 213Tyr Asn Glu Ile Val Ser Ile Leu Lys Glu His Leu Gly Asp Phe Lys
20 25 30GTG AGT TAT ATC AAA AAC CCT TAT GCT TTC TTC CAA AAG CAC ACC CAA 261Val Ser Tyr Ile Lys Asn Pro Tyr Ala Phe Phe Gln Lys His Thr Gln35 40 45 50GCA CAC ATT GAG CCT GCT ATT TTG GAT TTG GAT TAC ACC CCT TTA TAC 309Ala His Ile Glu Pro Ala Ile Leu Asp Leu Asp Tyr Thr Pro Leu Tyr
55 60 65GAT TTG GAA AGC GGC ATT AAA GAT TAT TTG CCC CAT ATC CAT GCG ATT 357Asp Leu Glu Ser Gly Ile Lys Asp Tyr Leu Pro His Ile His Ala Ile
70 75 80TTT AAA GGA CAG TGC GCA TGAAAAAAAT CTTAGTCATA GGCGATCTGA TCGCTGAT 413Phe Lys Gly Gln Cys Ala
85TATTATTTGT GGGGGAAGAG CGAACGGCTT T 444
(2) Sequence 440 data:
(i) sequence characteristics:
(A) length: 88 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 440: met Lys Ala Gln Lys Ser Gly Val Tyr Asn Val Gly Tyr Ser Gln Ala 151015 Arg Ser Tyr Asn Glu Ile Val Ser Ile Leu Lys Glu His Leu Gly Asp
20 25 30Phe Lys Val Ser Tyr Ile Lys Asn Pro Tyr Ala Phe Phe Gln Lys His
35 40 45Thr Gln Ala His Ile Glu Pro Ala Ile Leu Asp Leu Asp Tyr Thr Pro
50 55 60Leu Tyr Asp Leu Glu Ser Gly Ile Lys Asp Tyr Leu Pro His Ile His65 70 75 80Ala Ile Phe Lys Gly Gln Cys Ala
85
(2) Sequence 441 data:
(i) sequence characteristics:
(A) length: 822bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 153...728
(D) Other information:
(xi) Description of the sequence: sequence 441: CAGCATGCCG TTGTTTTTAA TGGGGATTTT TTTAAGCAAA ATTTCCGTTT CTTACAGGAA 60ATTTTTCAAT CTTTTGTCTA AAATTTTAAT GGGGGTTTTT GGGCTTTATA TCCTTTATAT 120GGGGATCATG CTCATTAACC ACAAAATGCC TC ATG CCA TGC ATC ATC AAA ACA 173
Met Pro Cys Ile Ile Lys Thr
1 5ACA CCA CTC AGC ATG ATC ATA AAG GAG TGC ATT CGC ATG AAC ACT AAC 221Thr Pro Leu Ser Met Ile Ile Lys Glu Cys Ile Arg Met Asn Thr Asn
10 15 20AAA GCC CTT TTT TTG GAC AGA GAC GGC ATT ATC AAT ATT GAT AAA GGC 269Lys Ala Leu Phe Leu Asp Arg Asp Gly Ile Ile Asn Ile Asp Lys Gly
25 30 35TAT GTG AGT CAA AAA GAA GAT TTT GAG TTT CAA AAA GGG ATT TTT GAA 317Tyr Val Ser Gln Lys Glu Asp Phe Glu Phe Gln Lys Gly lle Phe Glu40 45 50 55TTG CTA AAG CAT GCG AAA TCT TTA GGC TAC AAA CTG CTT TTA ATC ACC 365Leu Leu Lys His Ala Lys Ser Leu Gly Tyr Lys Leu Leu Leu Ile Thr
60 65 70AAC CAA TCT GGG ATC AAC CGA GGC TAT TAC ACC CTT AAA GAT TTT GAA 413Asn Gln Ser Gly Ile Asn Arg Gly Tyr Tyr Thr Leu Lys Asp Phe Glu
75 80 85CAA CTC ACC CAA TAC CTC CAA GAA AGC TTG TTC AAA GAA TTA GGT TTT 461Gln Leu Thr Gln Tyr Leu Gln Glu Ser Leu Phe Lys Glu Leu Gly Phe
90 95 100AAT CTG GAT GGC ATC TAT TTT TGC AGG CAC GCC CCA GAA GAA AAT TGC 509Asn Leu Asp Gly Ile Tyr Phe Cys Arg His Ala Pro Glu Glu Asn Cys
105 110 115GCT TGC AGG AAG CCA AAG CCT TCT TTG ATT TTG CAA GCT GCT AAA GAG 557Ala Cys Arg Lys Pro Lys Pro Ser Leu Ile Leu Gln Ala Ala Lys Glu120 125 130 135CAT CAA ATT TGC TTG GAG CAA TCT TTT ATG ATA GGC GAT AAA GAG AGC 605His Gln Ile Cys Leu Glu Gln Ser Phe Met Ile Gly Asp Lys Glu Ser
140 145 150GAC ATG TTA GCC GGC TTG AAC GCT AAA GTT AAA AAT AAC CTT TTG CTC 653Asp Met Leu Ala Gly Leu Asn Ala Lys Val Lys Asn Asn Leu Leu Leu
155 160 165ATT CAA AAC CCT TTA AAA ACT CCT CAT TCT TGG ATA CAA TGT AAA GAT 701Ile Gln Asn Pro Leu Lys Thr Pro His Ser Trp Ile Gln Cys Lys Asp
170 175 180TTT AAA GAG ATG ATA GAT CTA ATC AAA TAAGGACAAG AATGCGTTAT ATTGATG 755Phe Lys Glu Met Ile Asp Leu Ile Lys
185 190ATGAATTAGA AAATCAAACG ATTTTAATCA CCGGTGGGGC TGGCTTTGTA GGCAGTAATC 815TAGCCTT 822
(2) Data of sequence 442:
(i) sequence characteristics:
(A) length: 192 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 442: met Pro Cys Ile Ile Lys Thr Thr Pro Leu Ser Met Ile Ile Lys Glu 151015 Cys Ile Arg Met Asn Thr Asn Lys Ala Leu Phe Leu Asp Arg Asp Gly
20 25 30Ile Ile Asn Ile Asp Lys Gly Tyr Val Ser Gln Lys Glu Asp Phe Glu
35 40 45Phe Gln Lys Gly Ile Phe Glu Leu Leu Lys His Ala Lys Ser Leu Gly
50 55 60Tyr Lys Leu Leu Leu Ile Thr Asn Gln Ser Gly Ile Asn Arg Gly Tyr65 70 75 80Tyr Thr Leu Lys Asp Phe Glu Gln Leu Thr Gln Tyr Leu Gln Glu Ser
85 90 95Leu Phe Lys Glu Leu Gly Phe Asn Leu Asp Gly Ile Tyr Phe Cys Arg
100 105 110His Ala Pro Glu Glu Asn Cys Ala Cys Arg Lys Pro Lys Pro Ser Leu
115 120 125Ile Leu Gln Ala Ala Lys Glu His Gln Ile Cys Leu Glu Gln Ser Phe
130 135 140Met Ile Gly Asp Lys Glu Ser Asp Met Leu Ala Gly Leu Asn Ala Lys145 150 155 160Val Lys Asn Asn Leu Leu Leu Ile Gln Asn Pro Leu Lys Thr Pro His
165 170 175Ser Trp IleGln Cys Lys Asp Phe Lys Glu Met Ile Asp Leu Ile Lys
180 185 190
(2) Data of sequence 443:
(i) sequence characteristics:
(A) length: 831bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 88...756
(D) Other information:
(xi) Description of the sequence: sequence 443: AACAAAGAGC GAGAGAGCAT CAAGAAAGAG ATGAAAAAGA GCTTGAAGAA AGAAGAAAAG 60CTTTAGAAAT GAATAAGAAG TAGGCCT ATG CCA GCT AGG CAA TCT TTT ACA GAT 114
Met Pro Ala Arg Gln Ser Phe Thr Asp
1 5TTG AAA AAC CTG GTT TTG TGC GAT ATA GGC AAC ACG CGT ATC CAT TTT 162Leu Lys Asn Leu Val Leu Cys Asp Ile Gly Asn Thr Arg Ile His Phe10 15 20 25GCA CAA AAC TAT CAG CTC TTT TCA AGC GCT AAA GAA GAT TTA AAG CGT 210Ala Gln Asn Tyr Gln Leu Phe Ser Ser Ala Lys Glu Asp Leu Lys Arg
30 35 40TTG GGT ATT CAA AAG GAA ATT TTT TAC ATT AGC GTG AAT GAA GAA AAT 258Leu Gly Ile Gln Lys Glu Ile Phe Tyr Ile Ser Val Asn Glu Glu Asn
45 50 55GAA AAA GCC CTT TTG AAT TGT TAC CCT AAC GCT AAA AAT ATT GCA GGG 306Glu Lys Ala Leu Leu Asn Cys Tyr Pro Asn Ala Lys AsnIle Ala Gly
60 65 70TTT TTT CAT TTA GAA ACC GAC TAT GTA GGG CTT GGG ATA GAC CGG CAA 354Phe Phe His Leu Glu Thr Asp Tyr Val Gly Leu Gly Ile Asp Arg Gln
75 80 85ATG GCG TGT CTG GCG GTA AAT AAT GGC GTG GTG GTG GAT GCC GGG AGT 402Met Ala Cys Leu Ala Val Asn Asn Gly Val Val Val Asp Ala Gly Ser90 95 100 105GCG ATT ACG ATA GAT TTA ATC AAA GAG GGC AAG CAT TTA GGA GGG TGT 450Ala Ile Thr Ile Asp Leu Ile Lys Glu Gly Lys His Leu Gly Gly Cys
110 115 120ATT TTA CCC GGT TTA GCC CAA TAT ATT CAT GCG TAT AAA AAA AGC GCT 498Ile Leu Pro Gly Leu Ala Gln Tyr Ile His Ala Tyr Lys Lys Ser Ala
125 130 135AAA ATT TTA GAG CAA CCT TTC AAG GCC TTA GAT TCT TTA GAA GTT TTA 546Lys Ile Leu Glu Gln Pro Phe Lys Ala Leu Asp Ser Leu Glu Val Leu
140 145 150CCT AAA AGC ACT AGA GAC GCT GTG AAT TAC GGC ATG GTT TTG AGC GTC 594Pro Lys Ser Thr Arg Asp Ala Val Asn Tyr Gly Met Val Leu Ser Val
155 160 165ATT GCT TGT ATC CAG CAT TTA GCC AAA AAT CAA AAA ATC TAT CTT TGT 642Ile Ala Cys Ile Gln His Leu Ala Lys Asn Gln Lys Ile Tyr Leu Cys170 175 180 185GGG GGC GAT GCG AAG TAT TTG AGC GCG TTT TTA CCC CAT TCT GTT TGC 690Gly Gly Asp Ala Lys Tyr Leu Ser Ala Phe Leu Pro His Ser Val Cys
190 195 200AAG GAG CGT TTG GTT TTT GAC GGG ATG GAA ATC GCT CTT AAA AAA GCA 738Lys Glu Arg Leu Val Phe Asp Gly Met Glu Ile Ala Leu Lys Lys Ala
205 210215GGG ATA CTA GAA TGC AAA TGATGCACAA TTTGAGTTTT TTGGGCATGT TTTTAGCC 794G1y Ile Leu Glu Cys Lys
220GCTTTGAGCA TGTCTTTAGG GCATTGTGTG GGCATGT 831
(2) Sequence 444 data:
(i) sequence characteristics:
(A) length: 223 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 444: met Pro Ala Arg Gln Ser Phe Thr Asp Leu Lys Asn Leu Val Leu Cys 151015 Asp Ile Gly Asn Thr Arg Ile His Phe Ala Gln Asn Tyr Gln Leu Phe
20 25 30Ser Ser Ala Lys G1u Asp Leu Lys Arg Leu Gly Ile Gln Lys Glu Ile
35 40 45Phe Tyr Ile Ser Val Asn Glu Glu Asn Glu Lys Ala Leu Leu Asn Cys
50 55 60Tyr Pro Asn Ala Lys Asn Ile Ala Gly Phe Phe His Leu Glu Thr Asp65 70 75 80Tyr Val Gly Leu Gly Ile Asp Arg Gln Met Ala Cys Leu Ala Val Asn
85 90 95Asn Gly Va1 Val Val Asp Ala Gly Ser Ala Ile Thr Ile Asp Leu Ile
100 105 110Lys Glu Gly Lys His Leu Gly Gly Cys Ile Leu Pro Gly Leu Ala Gln
115 120 125Tyr Ile His Ala Tyr Lys Lys Ser Ala Lys Ile Leu Glu Gln Pro Phe
130 135140Lys Ala Leu Asp Ser Leu Glu Val Leu Pro Lys Ser Thr Arg Asp Ala145 150 155 160Val Asn Tyr Gly Met Val Leu Ser Val Ile Ala Cys Ile Gln His Leu
165 170 175Ala Lys Asn Gln Lys Ile Tyr Leu Cys Gly Gly Asp Ala Lys Tyr Leu
180 185 190Ser Ala Phe Leu Pro His Ser Val Cys Lys Glu Arg Leu Val Phe Asp
195 200 205Gly Met Glu Ile Ala Leu Lys Lys Ala Gly Ile Leu Glu Cys Lys
210 215 220
(2) Sequence 445 data:
(i) sequence characteristics:
(A) length: 1780bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 195...1709
(D) Other information:
(xi) Description of the sequence: sequence 445: TTGTTTTTAA TCTTTCTTAT TTTCATTAAT TGTTACGAAT AGAAATACTT AAGGGGGTTT 60TTCATTCTTA AAAAAAGGAT TTTTTAAGGA AATTGAATCT TGTTAGTCTT TGTATAACAA 120ATTATGTGAT AATCACCACA AGTAATCGGC TTAGTGTCAT ATTACGAAGA TTTAAGATCA 180TAAAAGGAAA AAAG ATG GTT AAT AAA GAT GTG AAA CAA ACC ACT GCT TTT 230
Met Val Asn Lys Asp Val Lys Gln Thr Thr Ala Phe
1 5 10GGC GCT CCC GTT TGG GATGAC AAC AAT GTG ATT ACG GCC GGC CCT AGA 278Gly Ala Pro Val Trp Asp Asp Asn Asn Val Ile Thr Ala Gly Pro Arg
15 20 25GGT CCT GTT TTA TTA CAA AGC ACT TGG TTT TTG GAA AAG TTA GCG GCG 326Gly Pro Val Leu Leu Gln Ser Thr Trp Phe Leu Glu Lys Leu Ala Ala
30 35 40TTT GAC AGA GAA AGA ATC CCT GAA AGG GTG GTG CAT GCT AAA GGA AGC 374Phe Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ser45 50 55 60GGA GCT TAT GGC ACT TTC ACT GTG ACT AAA GAC ATC ACT AAA TAC ACT 422Gly Ala Tyr Gly Thr Phe Thr Val Thr Lys Asp Ile Thr Lys Tyr Thr
65 70 75AAA GCG AAA ATT TTC TCT AAA GTG GGC AAA AAA ACC GAA TGC TTC TTC 470Lys Ala Lys Ile Phe Ser Lys Val Gly Lys Lys Thr Glu Cys Phe Phe
80 85 90AGA TTT TCT ACT GTG GCT GGT GAA AGA GGC AGT GCG GAT GCG GTG AGA 518Arg Phe Ser Thr Val Ala Gly Glu Arg Gly Ser Ala Asp Ala Val Arg
95 100 105GAC CCT AGA GGT TTT GCG ATG AAG TAT TAC ACT GAA GAA GGT AAC TGG 566Asp Pro Arg Gly Phe Ala Met Lys Tyr Tyr Thr Glu Glu Gly Asn Trp
110 115 120GAT TTA GTG GGG AAC AAC ACG CCT GTT TTC TTT ATC CGT GAT GCG ATC 614Asp Leu Val Gly Asn Asn Thr Pro Val Phe Phe Ile Arg Asp Ala Ile125 130 135 140AAA TTC CCT GAT TTC ATC CAC ACT CAA AAA CGA GAT CCT CAA ACC AAT 662Lys Phe Pro Asp Phe Ile His Thr Gln Lys Arg Asp Pro Gln Thr Asn
145 150 155TTG CCT AAC CAT GAC ATG GTA TGG GAT TTT TGG AGT AAT GTT CCT GAA 710Leu Pro Asn His Asp Met Val Trp Asp Phe Trp Ser Asn Val Pro Glu
160 165 170AGC TTA TAC CAA GTA ACA TGG GTT ATG AGC GAT AGG GGT ATT CCT AAA 758Ser Leu Tyr Gln Val Thr Trp Val Met Ser Asp Arg Gly Ile Pro Lys
175 180 185TCT TTC CGC CAC ATG GAT GGT TTT GGC AGC CAC ACT TTC AGT CTT ATC 806Ser Phe Arg His Met Asp Gly Phe Gly Ser His Thr Phe Ser Leu Ile
190 195 200AAC GCG AAA GGC GAA CGC TTT TGG GTG AAA TTC CAC TTT CAC ACC ATG 854Asn Ala Lys Gly Glu Arg Phe Trp Val Lys Phe His Phe His Thr Met205 210 215 220CAA GGC GTT AAG CAT TTG ACT AAC GAA GAA GCC GCA GAA GTT AGG AAG 902Gln Gly Val Lys His Leu Thr Asn Glu Glu Ala Ala Glu Val Arg Lys
225 230 235TAT GAT CCG GAT TCC AAT CAA AGG GAT TTA TTC AAT GCG ATC GCT AGA 950Tyr Asp Pro Asp Ser Asn Gln Arg Asp Leu Phe Asn Ala Ile Ala Arg
240 245 250GGG GAT TTC CCA AAA TGG AAA TTA AGC ATT CAA GTG ATG CCA GAA GAA 998Gly Asp Phe Pro Lys Trp Lys Leu Ser Ile Gln Val Met Pro Glu Glu
255 260 265GAT GCT AAG AAG TAT CGA TTC CAT CCG TTT GAT GTA ACT AAA ATT TGG 1046Asp Ala Lys Lys Tyr Arg Phe His Pro Phe Asp Val Thr Lys Ile Trp
270 275 280TAT CTC CAA GAT TAT CCA TTG ATG GAA GTG GGC ATT GTG GAG TTG AAT 1094Tyr Leu Gln Asp Tyr Pro Leu Met Glu Val Gly Ile Val Glu Leu Asn285 290 295 300AAA AAT CCT GAA AAC TAT TTC GCA GAA GTG GAA CAA GCG GCA TTC AGT 1142Lys Asn Pro Glu Asn Tyr Phe Ala Glu Val Glu Gln Ala Ala Phe Ser
305310 315CCG GCT AAT GTC GTT CCT GGA ATT GGC TAT AGC CCT GAT AGG ATG TTA 1190Pro Ala Asn Val Val Pro Gly Ile Gly Tyr Ser Pro Asp Arg Met Leu
320 325 330CAA GGG CGC TTG TTC TCT TAT GGA GAC ACA CAC CGC TAC CGC TTA GGC 1238Gln Gly Arg Leu Phe Ser Tyr Gly Asp Thr His Arg Tyr Arg Leu Gly
335 340 345GTT AAT TAT CCT CAA ATA CCG GTT AAT AAA CCA AGA TGC CCA TTC CAC 1286Val Asn Tyr Pro Gln Ile Pro Val Asn Lys Pro Arg Cys Pro Phe His
350 355 360TCT TCT AGC AGA GAT GGT TAC ATG CAA AAC GGA TAC TAC GGC TCT TTA 1334Ser Ser Ser Arg Asp Gly Tyr Met Gln Asn Gly Tyr Tyr Gly Ser Leu365 370 375 380CAA AAC TAT ACG CCT AGC TCA TTG CCT GGC TAT AAA GAA GAT AAG AGC 1382Gln Asn Tyr Thr Pro Ser Ser Leu Pro Gly Tyr Lys Glu Asp Lys Ser
385 390 395GCG AGA GAT CCT AAG TTC AAC TTA GCT CAT ATT GAG AAA GAG TTT GAA 1430Ala Arg Asp Pro Lys Phe Asn Leu Ala His Ile Glu Lys Glu Phe Glu
400 405 410GTG TGG AAT TGG GAT TAC AGA GCT GAT GAT AGC GAT TAC TAC ACC CAA 1478Val Trp Asn Trp Asp Tyr Arg Ala Asp Asp Ser Asp Tyr Tyr Thr Gln
415 420 425CCA GGT GAT TAC TAC CGC TCA TTG CCA GCT GAT GAA AAA GAA AGG TTG 1526Pro Gly Asp Tyr Tyr Arg Ser Leu Pro Ala Asp Glu Lys Glu Arg Leu
430 435 440CAT GAC ACT ATT GGA GAG TCT TTA GCT CAT GTT ACC CAT AAG GAA ATT 1574His Asp Thr Ile Gly Glu Ser Leu Ala His Val Thr His Lys Glu Ile445 450 455 460GTG GAT AAA CAA TTG GAG CAT TTC AAG AAA GCT GAC CCC AAA TAC GCT 1622Val Asp Lys Gln Leu Glu His Phe Lys Lys Ala Asp Pro Lys Tyr Ala
465 470 475GAG GGA GTT AAA AAA GCT CTT GAA AAA CAC CAA AAA ATG ATG AAA GAC 1670Glu Gly Val Lys Lys Ala Leu Glu Lys His Gln Lys Met Met Lys Asp
480 485 490ATG CAT GGA AAA GAC ATG CAC CAC ACA AAA AAG AAA AAG TAACCCTTTT CT 1721Met His Gly Lys Asp Met His His Thr Lys Lys Lys Lys
495 500 505TTAAGCGTTC TTATTTTTTA GGAACGCTTT GTCTTTCAAA ATTTAGGTTT TTGGATACT 1780
(2) Sequence 446 data:
(i) sequence characteristics:
(A) length: 505 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 446: met Val Asn Lys Asp Val Lys Gln Thr Thr Ala Phe Gly Ala Pro Val 151015 Trp Asp Asp Asn Asn Val Ile Thr Ala Gly Pro Arg Gly Pro Val Leu
20 25 30Leu Gln Ser Thr Trp Phe Leu Glu Lys Leu Ala Ala Phe Asp Arg Glu
35 40 45Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ser Gly Ala Tyr Gly
50 55 60Thr Phe Thr Val Thr Lys Asp Ile Thr Lys Tyr Thr Lys Ala Lys Ile65 70 75 80Phe Ser Lys Val Gly Lys Lys Thr Glu Cys Phe Phe Arg Phe Ser Thr
85 90 95Val Ala Gly Glu Arg Gly Ser Ala Asp Ala Val Arg Asp Pro Arg Gly
100 105 110Phe Ala Met Lys Tyr Tyr Thr Glu Glu Gly Asn Trp Asp Leu Val Gly
115 120 125Asn Asn Thr Pro Val Phe Phe Ile Arg Asp Ala Ile Lys Phe Pro Asp
130 135 140Phe Ile His Thr Gln Lys Arg Asp Pro Gln Thr Asn Leu Pro Asn His145 150 155 160Asp Met Val Trp Asp Phe Trp Ser Asn Val Pro Glu Ser Leu Tyr Gln
165 170 175Val Thr Trp Val Met Ser Asp Arg Gly Ile Pro Lys Ser Phe Arg His
180 185 190Met Asp Gly Phe Gly Ser His Thr Phe Ser Leu Ile Asn Ala Lys Gly
195 200 205Glu Arg Phe Trp Val Lys Phe His Phe His Thr Met Gln Gly Val Lys
210 215 220His Leu Thr Asn Glu Glu Ala Ala Glu Val Arg Lys Tyr Asp Pro Asp225 230 235 240Ser Asn Gln Arg Asp Leu Phe Asn Ala Ile Ala Arg Gly Asp Phe Pro
245 250 255Lys Trp Lys Leu Ser Ile Gln Val Met Pro Glu Glu Asp Ala Lys Lys
260 265 270Tyr Arg Phe His Pro Phe Asp Val Thr Lys Ile Trp Tyr Leu Gln Asp
275 280 285Tyr Pro Leu Met Glu Val Gly Ile Val Glu Leu Asn Lys Asn Pro Glu
290 295 300Asn Tyr Phe Ala Glu Val Glu Gln Ala Ala Phe Ser Pro Ala Asn Val305 310 315320Val Pro Gly Ile Gly Tyr Ser Pro Asp Arg Met Leu Gln Gly Arg Leu
325 330 335Phe Ser Tyr Gly Asp Thr His Arg Tyr Arg Leu Gly Val Asn Tyr Pro
340 345 350Gln Ile Pro Val Asn Lys Pro Arg Cys Pro Phe His Ser Ser Ser Arg
355 360 365Asp Gly Tyr Met Gln Asn Gly Tyr Tyr Gly Ser Leu Gln Asn Tyr Thr
370 375 380Pro Ser Ser Leu Pro Gly Tyr Lys Glu Asp Lys Ser Ala Arg Asp Pro385 390 395 400Lys Phe Asn Leu Ala His Ile Glu Lys Glu Phe Glu ValTrp Asn Trp
405 410 415Asp Tyr Arg Ala Asp Asp Ser Asp Tyr Tyr Thr Gln Pro Gly Asp Tyr
420 425 430Tyr Arg Ser Leu Pro Ala Asp Glu Lys Glu Arg Leu His Asp Thr Ile
435 440 445Gly Glu Ser Leu Ala His Val Thr His Lys Glu Ile Val Asp Lys Gln
450 455 460Leu Glu His Phe Lys Lys Ala Asp Pro Lys Tyr Ala Glu Gly Val Lys465 470 475 480Lys Ala Leu Glu Lys His Gln Lys Met Met Lys Asp Met His Gly Lys
485 490 495Asp Met His His Thr Lys Lys Lys Lys
500 505
(2) Sequence 447 data:
(i) sequence characteristics:
(A) length: 727bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...674
(D) Other information:
(xi) Description of the sequence: sequence 447: GAAGCGTGCC AAACCCGTTG CCCTTTGGCG TGGAGCTTGC CAAATATTGG ATG CAT 56
Met His
1AAC GGC TTT GTG AAT ATC AAT AAC GAA AAA ATG TCT AAA AGT TTG GGG 104Asn Gly Phe Val Asn Ile Asn Asn Glu Lys Met Ser Lys Ser Leu Gly
5 10 15AAT AGC TTT TTT GTT AAA GAC GCT CTC AAA AAC TAT GAT GGC GAA ATT 152Asn Ser Phe Phe Val Lys Asp Ala Leu Lys Asn Tyr Asp Gly Glu Ile
20 25 30TTG CGC AAT TAC TTA CTA GGG GTG CAT TAT CGC TCT GTT TTG AAT TTC 200Leu Arg Asn Tyr Leu Leu Gly Val His Tyr Arg Ser Val Leu Asn Phe35 40 45 50AAT GAA GAA GAC TTG TTA GTG AGT AAA AAA CGC TTG GAT AAA ATC TAT 248Asn Glu Glu Asp Leu Leu Val Ser Lys Lys Arg Leu Asp Lys Ile Tyr
55 60 65CGT TTA AAA CAG CGC GTT TTA GGG ACT CTT GGA GGA ATA AAT CCA AAC 296Arg Leu Lys Gln Arg Val Leu Gly Thr Leu Gly Gly Ile Asn Pro Asn
70 75 80TTT AAA AAA GAA ATT TTA GAG TGC ATG CAA GAT GAT TTA AAC GTT TCT 344Phe Lys Lys Glu Ile Leu Glu Cys Met Gln Asp Asp Leu Asn Val Ser
8590 95AAA GCG TTG AGC GTT TTA GAA AGC ATG CTT TCT TCC ACT AAT GAA AAA 392Lys Ala Leu Ser Val Leu Glu Ser Met Leu Ser Ser Thr Asn Glu Lys
100 105 110TTG GAT CAA AAC CCT AAA AAC AAG GCT TTA AAG GGC GAA ATT TTA GCG 440Leu Asp Gln Asn Pro Lys Asn Lys Ala Leu Lys Gly Glu Ile Leu Ala115 120 125 130AAT TTG AAA TTC ATA GAA GAA CTG CTT GGC ATC GGG TTT AAA GAC CCT 488Asn Leu Lys Phe Ile Glu Glu Leu Leu Gly Ile Gly Phe Lys Asp Pro
135 140 145AGC GCC TAT TTC CAA TTA GGC GTG AGT GAA AGC GAA AAA CAA GAA ATT 536Ser Ala Tyr Phe Gln Leu Gly Val Ser Glu Ser Glu Lys Gln Glu Ile
150 155 160GAA AAC AAG ATA GAA GAA AGA AAA CGC GCC AAA GAG CGA AAA GAT TTT 584Glu Asn Lys Ile Glu Glu Arg Lys Arg Ala Lys Glu Arg Lys Asp Phe
165 170 175TTA AAA GCC GAT AGC ATC AGA GAA GAG CTT TTG AAA CAA AAA ATC GCT 632Leu Lys Ala Asp Ser Ile Arg Glu Glu Leu Leu Lys Gln Lys Ile Ala
180 185 190TTG ATG GAC ACC CCA CAA GGC ACG ATC TGG GAG AAG TTT TTT TAAACACCT 683Leu Met Asp Thr Pro Gln Gly Thr Ile Trp Glu Lys Phe Phe195 200 205CCAATTTTAC CTTTTTACAC ATTCTAGCAA CAACTTTCAG CATT 727
(2) Sequence 448 data:
(i) sequence characteristics:
(A) length: 208 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 448: met His Asn Gly Phe Val Asn Ile Asn Asn Glu Lys Met Ser Lys Ser 151015 Leu Gly Asn Ser Phe Phe Val Lys Asp Ala Leu Lys Asn Tyr Asp Gly
20 25 30Glu Ile Leu Arg Asn Tyr Leu Leu Gly Val His Tyr Arg Ser Val Leu
35 40 45Asn Phe Asn Glu Glu Asp Leu Leu Val Ser Lys Lys Arg Leu Asp Lys
50 55 60Ile Tyr Arg Leu Lys Gln Arg Val Leu Gly Thr Leu Gly Gly Ile Asn65 70 75 80Pro Asn Phe Lys Lys Glu Ile Leu Glu Cys Met Gln Asp Asp Leu Asn
85 90 95Val Ser Lys Ala Leu Ser Val Leu Glu Ser Met Leu Ser Ser Thr Asn
100 105 110Glu Lys Leu Asp Gln Asn Pro Lys Asn Lys Ala Leu Lys Gly Glu Ile
115 120 125Leu Ala Asn Leu Lys Phe Ile Glu Glu Leu Leu Gly Ile Gly Phe Lys
130 135 140Asp Pro Ser Ala Tyr Phe Gln Leu Gly Val Ser Glu Ser Glu Lys Gln145 150 155 160Glu Ile Glu Asn Lys lle Glu Glu Arg Lys Arg Ala Lys Glu Arg Lys
165 170 175Asp Phe Leu Lys Ala Asp Ser Ile Arg Glu Glu Leu Leu Lys Gln Lys
180 185 190Ile Ala Leu Met Asp Thr Pro Gln Gly Thr Ile Trp Glu Lys Phe Phe
195 200 205
(2) Sequence 449data:
(i) sequence characteristics:
(A) length: 410bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 60...329
(D) Other information:
(xi) Description of the sequence: sequence 449: TTTTAAAAGC ATAGAGGATT TTAAGAAGCA TTGTGAAAAC TTATAAATAA GATTTAAAA 59ATG CTG ACG ATT GAA ACC AGT AAA AAA TTT GAT AAG GAT CTT AAA ATT 107Met Leu Thr Ile Glu Thr Ser Lys Lys Phe Asp Lys Asp Leu Lys Ile 151015 CTT GTT AAA AAC GGG TTT GAT TTA AAG CTT TTG TAT AAA GTG GTT GGA 155Leu Val Lys Asn Gly Phe Asp Leu Lys Leu Leu Tyr Lys Val Val Gly
20 25 30AAT TTA GCC ACA GAG CAA CCC CTA GCT CCC AAA TAC AAA GAC CAC CCA 203Asn Leu Ala Thr Glu Gln Pro Leu Ala Pro Lys Tyr Lys Asp His Pro
35 40 45CTC AAA GGC GGT TTA AAA GAT TTT AGG GAA TGC CAC TTA AAA CCG GAT 251Leu Lys Gly Gly Leu Lys Asp Phe Arg Glu Cys His Leu Lys Pro Asp
50 55 60TTA TTG CTT GTC TAT CAA ATT AAA AAA CAA GAA AAC ACC CTC TTT TTA 299Leu Leu Leu Val Tyr Gln Ile Lys Lys Gln Glu Asn Thr Leu Phe Leu 65 70 75 80GTA AGG TTA GGC AGT CAT AGC GAG CTG TTT TGAACCGCCC ACACCCCTTA TAAC 353Val Arg Leu Gly Ser His Ser Glu Leu Phe
85 90GCTTAAACCA ACTACCCCCC TTTTTTAGGG ATAAATTTAG GGTTGAAACA CCGCTTA 410
(2) Sequence 450 data:
(i) sequence characteristics:
(A) length: 90 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 450: met Leu Thr Ile Glu Thr Ser Lys Lys Phe Asp Lys Asp Leu Lys Ile 151015 Leu Val Lys Asn Gly Phe Asp Leu Lys Leu Leu Tyr Lys Val Val Gly
20 25 30Asn Leu Ala Thr Glu Gln Pro Leu Ala Pro Lys Tyr Lys Asp His Pro
35 40 45Leu Lys Gly Gly Leu Lys Asp Phe Arg Glu Cys His Leu Lys Pro Asp
50 55 60Leu Leu Leu Val Tyr Gln Ile Lys Lys Gln Glu Asn Thr Leu Phe Leu65 70 75 80Val Arg Leu Gly Ser His Ser Glu Leu Phe
85 90
(2) Sequence 451 data:
(i) sequence characteristics:
(A) length: 425bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 78...341
(D) Other information:
(xi) Description of the sequence: sequence 451: AGATGTAGGT AACAAAGAGA CAGATTTGAT TGTTGAGGAT TTTTCTAGTT ACAGCAATGA 60AAGAAAAAGG GCTTTAG GTG TTG AAG CTC AAT CTT AAA AAA TCT TTT CAA 110
Val Leu Lys Leu Asn Leu Lys Lys Ser Phe Gln
1 5 10AAA GAT TTT GAT AAA TTG CTT TTG AAT GGG TTT GAT GAT AGC GTT TTG 158Lys Asp Phe Asp Lys Leu Leu Leu Asn Gly Phe Asp Asp Ser Val Leu
15 20 25AAT GAA GTC ATT CTA ACC TTA AGA AAA AAA GAA CCG CTA GAT CCA CAA 206Asn Glu Val Ile Leu Thr Leu Arg Lys Lys Glu Pro Leu Asp Pro Gln
30 35 40TTT CAA GAT CAT GCC TTA AAG GGA AAG TGG AAA CCT TTT AGG GAA TGC 254Phe Gln Asp His Ala Leu Lys Gly Lys Trp Lys Pro Phe Arg Glu Cys
45 50 55CAC ATT AAG CCT GAT GTT TTG CTT GTG TAT TTA GTG AAA GAT GAT GAA 302His Ile Lys Pro Asp Val Leu Leu Val Tyr Leu Val Lys Asp Asp Glu60 65 70 75CTG ATT TTG TTA AGG TTA GGC AGT CAT AGC GAG CTG TTT TAATCCACCC AC 353Leu Ile Leu Leu Arg Leu Gly Ser His Ser Glu Leu Phe
80 85ACCCCTTATA ACGCTTAAAC CAAATCGCTT GCGCTATAAT GAACTGATAT TATATTTTAA 413AAGGAATAAA CA 425
(2) Sequence 452 data:
(i) sequence characteristics:
(A) length: 88 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 452: val Leu Lys Leu Asn Leu Lys Lys Ser Phe Gln Lys Asp Phe Asp Lys 151015 Leu Leu Leu Asn Gly Phe Asp Asp Ser Val Leu Asn Glu Val Ile Leu
20 25 30Thr Leu Arg Lys Lys Glu Pro Leu Asp Pro Gln Phe Gln Asp His Ala
35 40 45Leu Lys Gly Lys Trp Lys Pro Phe Arg Glu Cys His Ile Lys Pro Asp
50 55 60Val Leu Leu Val Tyr Leu Val Lys Asp Asp Glu Leu Ile Leu Leu Arg65 70 75 80Leu Gly Ser His Ser Glu Leu Phe
85
(2) Sequence 453 data:
(i) sequence characteristics:
(A) length: 844bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 111...779
(D) Other information:
(xi) Description of the sequence: sequence 453: GTCGTTATTC GCGCTTAATG AGAACAGAGG TTTTTAAAAC TATGGTTTCG TTTAGGTTTA 60ATTAAATTTC GCTACAATTA AATAAAAACG ATAATTTTAG AGAGATTGGC ATG CAA 116
Met Gln
1GGT TTA TGG ATT TAT CCA GAG GAT ACA GAA GTT TTA GGG GTT GCT TGT 164Gly Leu Trp Ile Tyr Pro Glu Asp Thr Glu Val Leu Gly Val Ala Cys
5 10 15AAG AGC CTT TTA AAA GCA CTA ACG CCA CGC TAT CAA AAA GTC GCC TTG 212Lys Ser Leu Leu Lys Ala Leu Thr Pro Arg Tyr Gln Lys Val Ala Leu
20 25 30TTT TCG CCC ATT AGT GGA GGG TGT GAG AGC TTG GAG GAG TGC GAG AGC 260Phe Ser Pro Ile Ser Gly Gly Cys Glu Ser Leu Glu Glu Cys Glu Ser35 40 45 50TTG AAC CCT TTA GAA TTT CAT AGT GCG ATA AGC AAA CAA AAG GCT TTA 308Leu Asn Pro Leu Glu Phe His Ser Ala Ile Ser Lys Gln Lys Ala Leu
55 60 65GAG CTT GCG AGC ACC GCT CAA GAA GAG TTA CTA TTT GAA ACG ATT CTC 356Glu Leu Ala Ser Thr Ala Gln Glu Glu Leu Leu Phe Glu Thr Ile Leu
70 75 80AAA CGC TAT GAT GAA TTA CAA TCC ACG CAT GAT TTT GTC ATT AAT TTG 404Lys Arg Tyr Asp Glu Leu Gln Ser Thr His Asp Phe Val Ile Asn Leu
85 90 95GGG TGT GCG CCG AAG TTT TTC TTA AAC GCT CCT TTA GAT TTA AAC ACC 452Gly Cys Ala Pro Lys Phe Phe Leu Asn Ala Pro Leu Asp Leu Asn Thr
100 105 110ATT TTA GCC AAG CAT TTA AAC GCT TCT GTT GTG GCT GTC GCG CAA ACG 500Ile Leu Ala Lys His Leu Asn Ala Ser Val Val Ala Val Ala Gln Thr115 120 125 130AGT TTG GAA TAT TTG AAA GCC ATG CAC TCT CAT ATT CTC AAA AAA GAA 548Ser Leu Glu Tyr Leu Lys Ala Met His Ser His Ile Leu Lys Lys Glu
135 140 145GCC CCT TTC GCT GTA GGG TTA TTT GCG GGC GAA ACG CTT GAA AAA CCA 596Ala Pro Phe Ala Val Gly Leu Phe Ala Gly Glu Thr Leu Glu Lys Pro
150 155 160CAT TTT TTA AGC ATG TCT CTT TGC AAG CAA CAA TGC GAA TTA GAA GCG 644His Phe Leu Ser Met Ser Leu Cys Lys Gln Gln Cys Glu Leu Glu Ala
165 170 175GAT CTG ATT GAA AGC GTG TTG CAA ATA AAA AGC GAG ATT ATT ACC CCT 692Asp Leu Ile Glu Ser Val Leu Gln Ile Lys Ser Glu Ile Ile Thr Pro
180 185 190TTA GCC TTT CAA AGG GGT TTG GAA AAA AAG GCT AAA AAA CAG ATT AAA 740Leu Ala Phe Gln Arg Gly Leu Glu Lys Lys Ala Lys Lys Gln Ile Lys195 200 205 210AAA GTG GTT TTA CCA GAG AGC GAA AAG ATG AAA GGA TTT TGAAAGCTGC AC 791Lys Val Val Leu Pro Glu Ser Glu Lys Met Lys Gly Phe
215 220ATCGTTTGAA TTTAATGGGC GCGGTAGGAT TGATCTTATT AGGCGATAAA GAA 844
(2) Sequence 454 data:
(i) sequence characteristics:
(A) length: 223 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 454: met Gln Gly Leu Trp Ile Tyr Pro Glu Asp Thr Glu Val Leu Gly Val 151015 Ala Cys Lys Ser Leu Leu Lys Ala Leu Thr Pro Arg Tyr Gln Lys Val
20 25 30Ala Leu Phe Ser Pro Ile Ser Gly Gly Cys Glu Ser Leu Glu Glu Cys
35 40 45Glu Ser Leu Asn Pro Leu Glu Phe His Ser Ala Ile Ser Lys Gln Lys
50 55 60Ala Leu Glu Leu Ala Ser Thr Ala Gln Glu Glu Leu Leu Phe Glu Thr65 70 75 80Ile Leu Lys Arg Tyr Asp Glu Leu Gln Ser Thr His Asp Phe Val Ile
85 90 95Asn Leu Gly Cys Ala Pro Lys Phe Phe Leu Asn Ala Pro Leu Asp Leu
100 105 110Asn Thr Ile Leu Ala Lys His Leu Asn Ala Ser Val Val Ala Val Ala
115 120 125Gln Thr Ser Leu Glu Tyr Leu Lys Ala Met His Ser His Ile Leu Lys
130 135 140Lys Glu Ala Pro Phe Ala Val Gly Leu Phe Ala Gly Glu Thr Leu Glu145 150 155 160Lys Pro His Phe Leu Ser Met Ser Leu Cys Lys Gln Gln Cys Glu Leu
165 170 175Glu Ala Asp Leu Ile Glu Ser Val Leu Gln Ile Lys Ser Glu Ile Ile
180 185 190Thr Pro Leu Ala Phe Gln Arg Gly Leu Glu Lys Lys Ala Lys Lys Gln
195 200 205Ile Lys Lys Val Val Leu Pro Glu Ser Glu Lys Met Lys Gly Phe
210 215 220
(2) Sequence 455 material:
(i) sequence characteristics:
(A) length: 821bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 79...753
(D) Other information:
(xi) Description of the sequence: sequence 455: TATGCCTGGA GGTTTGGTGT GGATGCGTCA AGATAATTTG CGNCTACAAC CGCAATTTAA 60AGCCAGAAAT TGGGCAAA ATG TGG AAT TTT AAC ACC GAA TAC AGC AGT CAG 111
Met Trp Asn Phe Asn Thr Glu Tyr Ser Ser Gln
1 5 10TAT TTT GAT TTT AGA GCC GCC GGT TTT GTC CAA TTG ATT TCT AAT TAC 159Tyr Phe Asp Phe Arg Ala Ala Gly Phe Val Gln Leu Ile Ser Asn Tyr
15 20 25ATC AAT CAA TTT TCT TCA ACG CTT TTT GTA ACC AAC TTG CCC GCA CAA 207Ile Asn Gln Phe Ser Ser Thr Leu Phe Val Thr Asn Leu Pro Ala Gln
30 35 40GAT ATT ATT TAT GTG CCT GGT TAT GAA GTT TCA GGG ACG GCT AAA TAC 255Asp Ile Ile Tyr Val Pro Gly Tyr Glu Val Ser Gly Thr Ala Lys Tyr
45 50 55AAG GGC TTT TCT TTA GGC TTG AGC GTG GCG CGA TCA TGG CCT TCT TTA 303Lys Gly Phe Ser Leu Gly Leu Ser Val Ala Arg Ser Trp Pro Ser Leu60 65 70 75AAG GGG CGT TTG ATC GCT GAT GTG TAT GAA TTG GCG GCC ACG ACA GGC 351Lys Gly Arg Leu Ile Ala Asp Val Tyr Glu Leu Ala Ala Thr Thr Gly
80 85 90AAT GTG TTT ATT TTG ACG GCA AGT TAT AAA ATC CCA CGC ACT GGT CTT 399Asn Val Phe Ile Leu Thr Ala Ser Tyr Lys Ile Pro Arg Thr Gly Leu
95 100105AGC ATC ACT TGG CTT TCA CGC TTC GTT ACG GAT TTG AGT TAT TGC TCT 447Ser Ile Thr Trp Leu Ser Arg Phe Val Thr Asp Leu Ser Tyr Cys Ser
110 115 120TAT AGC CCT TAT CGT AAC GGC CCT ACG GAT ATT GAC AGA CGG CCT AGT 495Tyr Ser Pro Tyr Arg Asn Gly Pro Thr Asp Ile Asp Arg Arg Pro Ser
125 130 135AAT TGC CCT AAA ACG CCC GGG ATT TTT CAT GTT CAT AAA CCC GGT TAT 543Asn Cys Pro Lys Thr Pro Gly Ile Phe His Val His Lys Pro Gly Tyr140 145 150 155GGG GTG AGC AGT TTT TTT GTA ACC TAC AAA CCC ACC TAT AAG AAG CTT 591Gly Val Ser Ser Phe Phe Val Thr Tyr Lys Pro Thr Tyr Lys Lys Leu
160 165 170AAA GGG TTG AGC TTG AAT GCG GTG TTT AAC AAT GTT TTT AAC CAA CAA 639Lys Gly Leu Ser Leu Asn Ala Val Phe Asn Asn Val Phe Asn Gln Gln
175 180 185TAT ATT GAT CAA GCA AGC CCG GTG ATG AGC CCT GAT GAA CCC AAT CAA 687Tyr Ile Asp Gln Ala Ser Pro Val Met Ser Pro Asp Glu Pro Asn Gln
190 195 200GAC AAA TAC GCA AGA GGC ATG GCA GAG CCT GGC TTT AAC GCT AGA TTT 735Asp Lys Tyr Ala Arg Gly Met Ala Glu Pro Gly Phe Asn Ala Arg Phe
205 210 215GAA ATT TCC TAT AAG TTT TAATAATGGA TCTAAAAATA AGGATTTCAT GGGTAGCG 791Glu Ile Ser Tyr Lys Phe220 225GATCTAATCA AAAATAAAAC ATTCTTTAGA 821
(2) Sequence 456 data:
(i) sequence characteristics:
(A) length: 225 amino acids
(B) Type (2): amino acids
(C) Chain type:sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 456: met Trp Asn Phe Asn Thr Glu Tyr Ser Ser Gln Tyr Phe Asp Phe Arg 151015 Ala Ala Gly Phe Val Gln Leu Ile Ser Asn Tyr Ile Asn Gln Phe Ser
20 25 30Ser Thr Leu Phe Val Thr Asn Leu Pro Ala Gln Asp Ile Ile Tyr Val
35 40 45Pro Gly Tyr Glu Val Ser Gly Thr Ala Lys Tyr Lys Gly Phe Ser Leu
50 55 60Gly Leu Ser Val Ala Arg Ser Trp Pro Ser Leu Lys Gly Arg Leu Ile65 70 75 80Ala Asp Val Tyr Glu Leu Ala Ala Thr Thr Gly Asn Val Phe Ile Leu
85 90 95Thr Ala Ser Tyr Lys Ile Pro Arg Thr Gly Leu Ser Ile Thr Trp Leu
100 105 110Ser Arg Phe Val Thr Asp Leu Ser Tyr Cys Ser Tyr Ser Pro Tyr Arg
115 120 125Asn Gly Pro Thr Asp Ile Asp Arg Arg Pro Ser Asn Cys Pro Lys Thr
130 135 140Pro Gly Ile Phe His Val His Lys Pro Gly Tyr Gly Val Ser Ser Phe145 150 155 160Phe Val Thr Tyr Lys Pro Thr Tyr Lys Lys Leu Lys Gly Leu Ser Leu
165 170 175Asn Ala Val Phe Asn Asn Val Phe Asn Gln Gln Tyr Ile Asp Gln Ala
180 185 190Ser Pro Val Met Ser Pro Asp Glu Pro Asn Gln Asp Lys Tyr Ala Arg
195 200 205Gly Met Ala Glu Pro Gly Phe Asn Ala Arg Phe Glu Ile Ser Tyr Lys
210 215 220Phe225
(2) Sequence 457 data:
(i) sequence characteristics:
(A) length: 1350bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 60...1202
(D) Other information:
(xi) Description of the sequence: sequence 457: AATTTTGAAA ACATTGACTC AGTTTCGCTC TCAAGGGCGT TTAATTCAAG GATCAAAGC 59ATG AAT TTA AAT TTT ATG CCC CTA TTG CAT GCT TAT AAC CAT GCG AGC 107Met Asn Leu Asn Phe Met Pro Leu Leu His Ala Tyr Asn His Ala Ser 151015 ATT GAT TTT CAT TTC AAT TCT AGT GCT AGG GAT TTT TGC GTG CAT GAA 155Ile Asp Phe His Phe Asn Ser Ser Ala Arg Asp Phe Cys Val His Glu
20 25 30GTG CCT TTG TAT GAA TTT AGT AAC ACG GGC GAA CAT GCC GTT ATT CAA 203Val Pro Leu Tyr Glu Phe Ser Asn Thr Gly Glu His Ala Val Ile Gln
35 40 45GTG AGG AAA AGC GGT TTA AGC ACT TTA GAA ATG CTT CAG ATT TTT TCT 251Val Arg Lys Ser Gly Leu Ser Thr Leu Glu Met Leu Gln Ile Phe Ser
50 55 60CAA ATT TTA GGG GTA AGA ATC GCT GAA TTG GGT TAT GCG GGC TTG AAA 299Gln Ile Leu Gly Val Arg Ile Ala Glu Leu Gly Tyr Ala Gly Leu Lys 65 70 75 80GAT AAA AAC GCG CTG ACG ACT CAA TTC ATC TCA CTC CCT AAA AAA TAC 347Asp Lys Asn Ala Leu Thr Thr Gln Phe Ile Ser Leu Pro Lys Lys Tyr
85 90 95GCC CCT TTA TTA GAA AAA AAT ACG AGC AAC TTT CAA GAA AAA AAC CTT 395Ala Pro Leu Leu Glu Lys Asn Thr Ser Asn Phe Gln Glu Lys Asn Leu
100 105 110AAA ATC CTG TCT TTG AAT TAC CAC CAC AAT AAA ATC AAA TTG GGG CAT 443Lys Ile Leu Ser Leu Asn Tyr His His Asn Lys Ile Lys Leu Gly His
115 120 125TTG AAA GGG AAT CGC TTT TTT ATG CGT TTT AAA AAA ATG ACC CCT CTA 491Leu Lys Gly Asn Arg Phe Phe Met Arg Phe Lys Lys Met Thr Pro Leu
130 135 140AAC GCT CAA AAA ACA AAG CAG GTT TTA GAA CAA ATC GCG CAG TTT GGA 539Asn Ala Gln Lys Thr Lys Gln Val Leu Glu Gln Ile Ala Gln Phe Gly145 150 155 160ATG CCT AAT TAT TTT GGC TCG CAA CGC TTT GGG AAG TTC AAT GAC AAC 587Met Pro Asn Tyr Phe Gly Ser Gln Arg Phe Gly Lys Phe Asn Asp Asn
165 170 175CAC CAA GAG GGT TTA AAA ATC TTA CAA AAT CAA ACG AAA TTC GCC CAT 635His Gln Glu Gly Leu Lys Ile Leu Gln Asn Gln Thr Lys Phe Ala His
180 185 190CAA AAA TTA AAC GCT TTT TTA ATT TCA AGC TAT CAA AGT TAT TTG TTT 683Gln Lys Leu Asn Ala Phe Leu Ile Ser Ser Tyr Gln Ser Tyr Leu Phe
195 200 205AAC GCG CTT TTA AGC AAA CGA TTA GAA ATC AGT AAA ATC ATT AGC GCT 731Asn Ala Leu Leu Ser Lys Arg Leu Glu Ile Ser Lys Ile Ile Ser Ala
210 215 220TTT AGT GTC AAA GAA AAT TTA GAA TTT TTT AAA CAA AAA AAT TTA AGC 779Phe Ser Val Lys Glu Asn Leu Glu Phe Phe Lys Gln Lys Asn Leu Ser225 230 235 240GTT GAT TCA GAC ACT CTA AAA ACC CTT AAA AAC CAA GCC CAC CCC TTT 827Val Asp Ser Asp Thr Leu Lys Thr Leu Lys Asn Gln Ala His Pro Phe
245 250 255AAA ATC TTA GAA GGC GAT GTG ATG TGC CAT TAC CCT TAT GGG AAG TTT 875Lys Ile Leu Glu Gly Asp Val Met Cys His Tyr Pro Tyr Gly Lys Phe
260 265 270TTT GAC GCT TTA GAA TTA GAA AAA GAG GGC GAA AGG TTT TTG AAA AAA 923Phe Asp Ala Leu Glu Leu Glu Lys Glu Gly Glu Arg Phe Leu Lys Lys
275 280 285GAA GTT GCG CCT ACG GGG TTA CTA GAC GGC AAA AAA GCT CTT TAT GCA 971Glu Val Ala Pro Thr Gly Leu Leu Asp Gly Lys Lys Ala Leu Tyr Ala
290 295 300AAA AAT TTG AGT TTA GAA ATT GAA AAA GAA TTC CAG CAT AAC CTT TTA 1019Lys Asn Leu Ser Leu Glu Ile Glu Lys Glu Phe Gln His Asn Leu Leu305 310 315 320AGT AGC CAT GCT AAA ACG CTA GGC TCT AGG CGG TTT TTT TGG GTG TTT 1067Ser Ser His Ala Lys Thr Leu Gly Ser Arg Arg Phe Phe Trp Val Phe
325 330 335GTA GAA AAT GTA ACT TCT CAA TAC GTG AAA GAA AAA GCG CAA TTT GAA 1115Val Glu Asn Val Thr Ser Gln Tyr Val Lys Glu Lys Ala Gln Phe Glu
340 345 350TTG GGA TTT TAC TTG CCT AAA GGG AGT TAT GCG AGC GCG TTG CTC AAA 1163Leu Gly Phe Tyr Leu Pro Lys Gly Ser Tyr Ala Ser Ala Leu Leu Lys
355 360 365GAA ATC AAG CAT GAG AAA GGA GAA AAT AAT GAC GAA TTT TGAAAAGATT ATC 1215Glu Ile Lys His Glu Lys Gly Glu Asn Asn Asp Glu Phe
370 375 380GCGCAAAACA GGATCAAAAC GAACGCGGTT TTAGCGACTT ATTGCGTGAT TTTTGCTTTT 1275ATCGGGTTGT TGGTGGATGT CATTAGAATT AATGCTAATG ATTTAGGAAT AGCTCTTTTT 1335AAACTCATGA CTTTT 1350
(2) Sequence 458 data:
(i) sequence characteristics:
(A) length: 381 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 458: met Asn Leu Asn Phe Met Pro Leu Leu His Ala Tyr Asn His Ala Ser 151015 Ile Asp Phe His Phe Asn Ser Ser Ala Arg Asp Phe Cys Val His Glu
20 25 30Val Pro Leu Tyr Glu Phe Ser Asn Thr Gly Glu His Ala Val Ile Gln
35 40 45Val Arg Lys Ser Gly Leu Ser Thr Leu Glu Met Leu Gln Ile Phe Ser
50 55 60Gln Ile Leu Gly Val Arg Ile Ala Glu Leu Gly Tyr Ala Gly Leu Lys65 70 75 80Asp Lys Asn Ala Leu Thr Thr Gln Phe Ile Ser Leu Pro Lys Lys Tyr
85 90 95Ala Pro Leu Leu Glu Lys Asn Thr Ser Asn Phe Gln Glu Lys Asn Leu
100 105 110Lys Ile Leu Ser Leu Asn Tyr His His Asn Lys Ile Lys Leu Gly His
115 120125Leu Lys Gly Asn Arg Phe Phe Met Arg Phe Lys Lys Met Thr Pro Leu
130 135 140Asn Ala Gln Lys Thr Lys Gln Val Leu Glu Gln Ile Ala Gln Phe Gly145 150 155 160Met Pro Asn Tyr Phe Gly Ser Gln Arg Phe Gly Lys Phe Asn Asp Asn
165 170 175His Gln Glu Gly Leu Lys Ile Leu Gln Asn Gln Thr Lys Phe Ala His
180 185 190Gln Lys Leu Asn Ala Phe Leu Ile Ser Ser Tyr Gln Ser Tyr Leu Phe
195 200 205Asn Ala Leu Leu Ser Lys Arg Leu Glu Ile Ser Lys Ile Ile Ser Ala
210 215 220Phe Ser Val Lys Glu Asn Leu Glu Phe Phe Lys Gln Lys Asn Leu Ser225 230 235 240Val Asp Ser Asp Thr Leu Lys Thr Leu Lys Asn Gln Ala His Pro Phe
245 250 255Lys Ile Leu Glu Gly Asp Val Met Cys His Tyr Pro Tyr Gly Lys Phe
260 265 270Phe Asp Ala Leu Glu Leu Glu Lys Glu Gly Glu Arg Phe Leu Lys Lys
275 280 285Glu Val Ala Pro Thr Gly Leu Leu Asp Gly Lys Lys Ala Leu Tyr Ala
290 295 300Lys Asn Leu Ser Leu Glu Ile Glu Lys Glu Phe Gln His Asn Leu Leu305 310 315 320Ser Ser His Ala Lys Thr Leu Gly Ser Arg Arg Phe Phe Trp Val Phe
325 330 335Val Glu Asn Val Thr Ser Gln Tyr Val Lys Glu Lys Ala Gln Phe Glu
340345 350Leu Gly Phe Tyr Leu Pro Lys Gly Ser Tyr Ala Ser Ala Leu Leu Lys
355 360 365Glu Ile Lys His Glu Lys Gly Glu Asn Asn Asp Glu Phe
370 375 380
(2) Sequence 459 data:
(i) sequence characteristics:
(A) length: 1080bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 76...828
(D) Other information:
(xi) Description of the sequence: sequence 459: CTTTTTCAAT AAAATCATCA GCGATGAAAA ACAATGCTTT TTCCACGCTA AACCCTTACA 60CCAGATCCCT TAAAA ATG AAA CTC CCG GTC GTT GAG AGC TTT TTT TCC TTA 111
Met Lys Leu Pro Val Val Glu Ser Phe Phe Ser Leu
1 5 10CAA GGT GAA GGA AAA AGG ATA GGC AAG CCC AGT CTT TTT TTG CGC TTA 159Gln Gly Glu Gly Lys Arg Ile Gly Lys Pro Ser Leu Phe Leu Arg Leu
15 20 25GGG GGG TGT AAC CTT TCA TGC AAG GGC TTT AAT TGT AAA ACC TTA TTG 207Gly Gly Cys Asn Leu Ser Cys Lys Gly Phe Asn Cys Lys Thr Leu Leu
30 35 40AAT GAT GAA ATC CTA ACA GGT TGC GAC AGC TTG TAT GCG GTG CAT CCC 255Asn Asp Glu Ile Leu Thr Gly Cys Asp Ser Leu Tyr Ala Val His Pro45 5055 60AAA TTC AAA ACA TCT TGG GAT TAT TAT AAT GAG CCT AAG CCC TTG ATT 303Lys Phe Lys Thr Ser Trp Asp Tyr Tyr Asn Glu Pro Lys Pro Leu Ile
65 70 75GAA CGA TTA GAG GAT TTA GCC CCT AAT TAT AAG GAT TTT GAT TTC ATT 351Glu Arg Leu Glu Asp Leu Ala Pro Asn Tyr Lys Asp Phe Asp Phe Ile
80 85 90CTT ACA GGC GGG GAG CCA AGC TTG TAT TTC AAT AAC CCT ATT TTA ATC 399Leu Thr Gly Gly Glu Pro Ser Leu Tyr Phe Asn Asn Pro Ile Leu Ile
95 100 105AGC GTT TTA GAG CAT TTT TAT CGC CAA AAA ATC CCT TTA TGT GTA GAG 447Ser Val Leu Glu His Phe Tyr Arg Gln Lys Ile Pro Leu Cys Val Glu
110 115 120AGT AAT GGT TCT ATT TTT TTT GAA TTT AGC CCT ATT TTA AAA GAA TTG 495Ser Asn Gly Ser Ile Phe Phe Glu Phe Ser Pro Ile Leu Lys Glu Leu125 130 135 140CAT TTC ACT CTA AGC GTC AAA CTC TCT TTT TCT TTA GAG GAA GAA AGC 543His Phe Thr Leu Ser Val Lys Leu Ser Phe Ser Leu Glu Glu Glu Ser
145 150 155AAG CGG ATC CAT CTT AAA GCC TTA CAA AAT ATC TTA AAT AAC GCT AAA 591Lys Arg Ile His Leu Lys Ala Leu Gln Asn Ile Leu Asn Asn Ala Lys
160 165 170AGC GCG CAT TTT AAA TTT GTT TTA GAG AGC CAA AAC GCC GCT CAA TCT 639Ser Ala His Phe Lys Phe Val Leu Glu Ser Gln Asn Ala Ala Gln Ser
175 180 185ATT ATA GAA ATT CAA AGC CTC TTG AAA CAA CTC TCC TTA AAA AAT AAT 687Ile Ile Glu Ile Gln Ser Leu Leu Lys Gln Leu Ser Leu Lys Asn Asn
190 195 200GAA ATC TTT TTA ATG CCT TTA GGC ACA AAT AAC AAC GAG CTA GAC AAA 735Glu Ile Phe Leu Met Pro Leu Gly Thr Asn Asn Asn Glu Leu Asp Lys205 210 215 220AAT CTA AAA ACC CTA GCC CCC CTA GCC ATA AAG CAT GGT TTC AGG CTA 783Asn Leu Lys Thr Leu Ala Pro Leu Ala Ile Lys His Gly Phe Arg Leu
225 230 235AGC GAT AGG CTT CAT ATC CGC TTG TGG GAT AAT CAA AAA GGG TTT TAAAA 833Ser Asp Arg Leu His Ile Arg Leu Trp Asp Asn Gln Lys Gly Phe
240 245 250AGTTAATCAT GACCATCAAA GTTTTTTCGC CCAAATACCC CACTGAATTA GAAGAATTTT 893ATGCTGAGCG TATCGCTGAC AACCCTTTAG GGTTTATCCA ACGCTTGGAT CTTTTGCCTA 953GTATTAGCGG GTTCGTTCAA AAATTGCGCG AGCATGGCGG GGAATTTTTT GAAATGAGAG 1013AGGGTAACAA GCTCATTGGG ATTTGTGGGC TTAATCCTAT CAATCAAACA GAAGCCGAGC 1073TGTGCAA 1080
(2) Sequence 460 data:
(i) sequence characteristics:
(A) length: 251 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 460: met Lys Leu Pro Val Val Glu Ser Phe Phe Ser Leu Gln Gly Glu Gly 151015 Lys Arg Ile Gly Lys Pro Ser Leu Phe Leu Arg Leu Gly Gly Cys Asn
20 25 30Leu Ser Cys Lys Gly Phe Asn Cys Lys Thr Leu Leu Asn Asp Glu Ile
35 40 45Leu Thr Gly Cys Asp Ser Leu Tyr Ala Val His Pro Lys Phe Lys Thr
5055 60Ser Trp Asp Tyr Tyr Asn Glu Pro Lys Pro Leu Ile Glu Arg Leu Glu65 70 75 80Asp Leu Ala Pro Asn Tyr Lys Asp Phe Asp Phe Ile Leu Thr Gly Gly
85 90 95Glu Pro Ser Leu Tyr Phe Asn Asn Pro Ile Leu Ile Ser Val Leu Glu
100 105 110His Phe Tyr Arg Gln Lys Ile Pro Leu Cys Val Glu Ser Asn Gly Ser
115 120 125Ile Phe Phe Glu Phe Ser Pro Ile Leu Lys Glu Leu His Phe Thr Leu
130 135 140Ser Val Lys Leu Ser Phe Ser Leu Glu Glu Glu Ser Lys Arg Ile His145 150 155 160Leu Lys Ala Leu Gln Asn Ile Leu Asn Asn Ala Lys Ser Ala His Phe
165 170 175Lys Phe Val Leu Glu Ser Gln Asn Ala Ala Gln Ser Ile Ile Glu Ile
180 185 190Gln Ser Leu Leu Lys Gln Leu Ser Leu Lys Asn Asn Glu Ile Phe Leu
195 200 205Met Pro Leu Gly Thr Asn Asn Asn Glu Leu Asp Lys Asn Leu Lys rhr
210 215 220Leu Ala Pro Leu Ala Ile Lys His Gly Phe Arg Leu Ser Asp Arg Leu225 230 235 240His Ile Arg Leu Trp Asp Asn Gln Lys Gly Phe
245 250
(2) Data of sequence 461:
(i) sequence characteristics:
(A) length: 1710bp
(B) Type (2): nucleic acids
(C)Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 120...1559
(D) Other information:
(xi) Description of the sequence: sequence 461: TAAAGAATTT TGTGAATATT GATTGTCTCT TTTAATTGAA ATTTAAAGAT TAGTTTAAAG 60GATTTTATTC GGTGGGATTG TCAGCATCAA GCCTCATTGT TCCTATTAGC GTTATTTTA 119ATG GTG GTT TTT ACT AAA AGA GTC GCA CTC TCG TTA TTT GTG GGC ATT 167Met Val Val Phe Thr Lys Arg Val Ala Leu Ser Leu Phe Val Gly Ile 151015 TTA GTG AGC GCT GTT TTA ATG CAT TCG TTA CAC CTT TCC CAA CTC GTA 215Leu Val Ser Ala Val Leu Met His Ser Leu His Leu Ser Gln Leu Val
20 25 30GAA TAT ATT TAT CAT AAA ATC ACT TCC GTT TTT TAC ACT TAC GAG CCA 263Glu Tyr Ile Tyr His Lys Ile Thr Ser Val Phe Tyr Thr Tyr Glu Pro
35 40 45GAA AAG GGG CTT AAT TTC AAT CTT TCC AAC CTC TAT GTT TTT GGG TTT 311Glu Lys Gly Leu Asn Phe Asn Leu Ser Asn Leu Tyr Val Phe Gly Phe
50 55 60TTA ATC TTT TTA GGC GTC TTA AGC CAA GTG ATT TTA AAA TCC GGT AGC 359Leu Ile Phe Leu Gly Val Leu Ser Gln Val Ile Leu Lys Ser Gly Ser 65 70 75 80GTG CAA AAC TTT GTC AAA AAA GCT AAA AAA TAC TCA AAA AAC GCT AAA 407Val Gln Asn Phe Val Lys Lys Ala Lys Lys Tyr Ser Lys Asn Ala Lys
85 90 95ACT CCC GAA TTT ATC GCC TTT TTT TCA GGT ATC ATT ATT TTT GTA GAT 455Thr Pro Glu Phe Ile Ala Phe Phe Ser Gly Ile Ile Ile Phe Val Asp
100 105 110GAT TAT TTT AAC GCC CTA ACC GTG GGG CAA ATC TCA AAG TCT TTA AAC 503Asp Tyr Phe Asn Ala Leu Thr Val Gly Gln Ile Ser Lys Ser Leu Asn
115 120 125GAC GCT CAT AAC TCC ACA CGA GAG CGC TTG GCT TAT ATT ATA GAC TCC 551Asp Ala His Asn Ser Thr Arg Glu Arg Leu Ala Tyr Ile Ile Asp Ser
130 135 140ACT TCA GCG CCG GTG TGC TTG CTA GTC CCC ATT TCT AGT TGG GGG GCG 599Thr Ser Ala Pro Val Cys Leu Leu Val Pro Ile Ser Ser Trp Gly Ala145 150 155 160TAT ATT ATG GGG ATC ATG AAT AAC GAC AGC TCG CCC TTA TTA AAA GAT 647Tyr Ile Met Gly Ile Met Asn Asn Asp Ser Ser Pro Leu Leu Lys Asp
165 170 175AGT TTT TCG GTG CTT GTG CAA AGC TTA AGC AGT AAT TAT TAT GCC ATT 695Ser Phe Ser Val Leu Val Gln Ser Leu Ser Ser Asn Tyr Tyr Ala Ile
180 185 190TTT GCA CTC ATT GCA GTC TTT CTC ACC ATT TTA TGG CAA ATC AAC CTC 743Phe Ala Leu Ile Ala Val Phe Leu Thr Ile Leu Trp Gln Ile Asn Leu
195 200 205CCT AGC ATG AGA AAG TAT CAA AAC ATA GGC GTG AAG GAT TTT TAT AGC 791Pro Ser Met Arg Lys Tyr Gln Asn Ile Gly Val Lys Asp Phe Tyr Ser
210 215 220GAA CAA GAA GAA AGC TCT TCA AAA CTA GCC CCC TTG AGT TTG TTA CCC 839Glu Gln Glu Glu Ser Ser Ser Lys Leu Ala Pro Leu Ser Leu Leu Pro225 230 235 240CTT TCT ATT TTA TTG TTG ATT GTG TCC ATT TCA TCA TTG CTT TTT TAT 887Leu Ser Ile Leu Leu Leu Ile Val Ser Ile Ser Ser Leu Leu Phe Tyr
245 250 255ACA GGA GTG ATT TTA AAA AAC ACT GAT GCG AGT TTT TCG CTC TTT TAT 935Thr Gly Val Ile Leu Lys Asn Thr Asp Ala Ser Phe Ser Leu Phe Tyr
260 265 270GGA GGG TTG TTT TCG CTC ATC GTT ACT TAT CTT TTA GCT TAT AAG TTT 983Gly Gly Leu Phe Ser Leu Ile Val Thr Tyr Leu Leu Ala Tyr Lys Phe
275 280 285TTA GAA AAA GGG AGC TTT TTT AAA CTC ATG TTG GAT GGC TTT AAG AGT 1031Leu Glu Lys Gly Ser Phe Phe Lys Leu Met Leu Asp Gly Phe Lys Ser
290 295 300GTG GGG CCG GCG ATA CTA GTC TTA ACG CTC GCT TGG GCT ATC GGG CCT 1079Val Gly Pro Ala Ile Leu Val Leu Thr Leu Ala Trp Ala Ile Gly Pro305 310 315 320GTG ATT AGA GAT GAC GCT CAA ACA GGG CTT TAC TTG GCT AAC ATC AGC 1127Val Ile Arg Asp Asp Ala Gln Thr Gly Leu Tyr Leu Ala Asn Ile Ser
325 330 335AAG GGG TTT TTA AAT AAT GGA GGA GGC GTG TAT ATG CCT TTA ATC TTT 1175Lys Gly Phe Leu Asn Asn Gly Gly Gly Val Tyr Met Pro Leu Ile Phe
340 345 350TTT TTA ATC TCT GGG TTT ATC GCT TTT TCT ACC GGC ACA AGC TGG GGA 1223Phe Leu Ile Ser Gly Phe Ile Ala Phe Ser Thr Gly Thr Ser Trp Gly
355 360 365GCG TTT GCG ATC ATG CTT CCC ATT GGA GCG GGC ATG GCT AGT GAA AGC 1271Ala Phe Ala Ile Met Leu Pro Ile Gly Ala Gly Met Ala Ser Glu Ser
370 375 380GAT ATT ATT TTG ATT GTT TCA GCG ATT CTC TCA GGC GCG GTT TAT GGC 1319Asp Ile Ile Leu Ile Val Ser Ala Ile Leu Ser Gly Ala Val Tyr Gly385 390 395 400GAT CAC ACA AGC CCT ATT TCT GAC ACG ACT ATA CTA TCG GCT ACG GGG 1367Asp His Thr Ser Pro Ile Ser AspThr Thr Ile Leu Ser Ala Thr Gly
405 410 415GCA GGG TGT TCG GTG CAA AGC CAT TTT ATC ACG CAA CTC CCT TAT GCG 1415Ala Gly Cys Ser Val Gln Ser His Phe Ile Thr Gln Leu Pro Tyr Ala
420 425 430ACC ATT GCG ATG CTT TGC AGC GCG GTG AGT TTG GGG GTG GCA AGC TTT 1463Thr Ile Ala Met Leu Cys Ser Ala Val Ser Leu Gly Val Ala Ser Phe
435 440 445ATG TAT TCG CGT TCG CTC GCT CTT TTA ATC GGT GTG GCT TTG CTT GTG 1511Met Tyr Ser Arg Ser Leu Ala Leu Leu Ile Gly Val Ala Leu Leu Val
450 455 460GGG GTG TTT TAT CTT TTA AAA AAA TTT TAT GGT GAA AAT CTA AAA ACT TG 1561Gly Val Phe Tyr Leu Leu Lys Lys Phe Tyr Gly Glu Asn Leu Lys Thr465 470 475 480AATATTGATT GAAGAAGCTT AAAAATCCCA TTTTTTAAAA TTAAAATAAG GTTTTATCGA 1621TCCCTATTTG ACTCAAAAAG AGTCTTATTC CATTATCAAT CAATTAAAAA AGGTTATTCA 1681AAAATAACCA TACAATTATA AAAATCTTC 1710
(2) Sequence 462 data:
(i) sequence characteristics:
(A) length: 480 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 462: met Val Val Phe Thr Lys Arg Val Ala Leu Ser Leu Phe Val Gly Ile 151015 Leu Val Ser Ala Val Leu Met His Ser Leu His Leu Ser Gln Leu Val
20 2530Glu Tyr Ile Tyr His Lys Ile Thr Ser Val Phe Tyr Thr Tyr Glu Pro
35 40 45Glu Lys Gly Leu Asn Phe Asn Leu Ser Asn Leu Tyr Val Phe Gly Phe
50 55 60Leu Ile Phe Leu Gly Val Leu Ser Gln Val Ile Leu Lys Ser Gly Ser65 70 75 80Val Gln Asn Phe Val Lys Lys Ala Lys Lys Tyr Ser Lys Asn Ala Lys
85 90 95Thr Pro Glu Phe Ile Ala Phe Phe Ser Gly Ile Ile Ile Phe Val Asp
100 105 110Asp Tyr Phe Asn Ala Leu Thr Val Gly Gln Ile Ser Lys Ser Leu Asn
115 120 125Asp Ala His Asn Ser Thr Arg Glu Arg Leu Ala Tyr Ile Ile Asp Ser
130 135 140Thr Ser Ala Pro Val Cys Leu Leu Val Pro Ile Ser Ser Trp Gly Ala145 150 155 160Tyr Ile Met Gly Ile Met Asn Asn Asp Ser Ser Pro Leu Leu Lys Asp
165 170 175Ser Phe Ser Val Leu Val Gln Ser Leu Ser Ser Asn Tyr Tyr Ala Ile
180 185 190Phe Ala Leu Ile Ala Val Phe Leu Thr Ile Leu Trp Gln Ile Asn Leu
195 200 205Pro Ser Met Arg Lys Tyr Gln Asn Ile Gly Val Lys Asp Phe Tyr Ser
210 215 220Glu Gln Glu Glu Ser Ser Ser Lys Leu Ala Pro Leu Ser Leu Leu Pro225 230 235 240Leu Ser Ile Leu Leu Leu Ile Val Ser Ile Ser Ser Leu Leu Phe Tyr
245 250 255Thr Gly Val Ile LeuLys Asn Thr Asp Ala Ser Phe Ser Leu Phe Tyr
260 265 270Gly Gly Leu Phe Ser Leu Ile Val Thr Tyr Leu Leu Ala Tyr Lys Phe
275 280 285Leu Glu Lys Gly Ser Phe Phe Lys Leu Met Leu Asp Gly Phe Lys Ser
290 295 300Val Gly Pro Ala Ile Leu Val Leu Thr Leu Ala Trp Ala Ile Gly Pro305 310 315 320Val Ile Arg Asp Asp Ala Gln Thr Gly Leu Tyr Leu Ala Asn Ile Ser
325 330 335Lys Gly Phe Leu Asn Asn Gly Gly Gly Val Tyr Met Pro Leu Ile Phe
340 345 350Phe Leu Ile Ser Gly Phe Ile Ala Phe Ser Thr Gly Thr Ser Trp Gly
355 360 365Ala Phe Ala Ile Met Leu Pro Ile Gly Ala Gly Met Ala Ser Glu Ser
370 375 380Asp Ile Ile Leu Ile Val Ser Ala Ile Leu Ser Gly Ala Val Tyr Gly385 390 395 400Asp His Thr Ser Pro Ile Ser Asp Thr Thr Ile Leu Ser Ala Thr Gly
405 410 415Ala Gly Cys Ser Val Gln Ser His Phe Ile Thr Gln Leu Pro Tyr Ala
420 425 430Thr Ile Ala Met Leu Cys Ser Ala Val Ser Leu Gly Val Ala Ser Phe
435 440 445Met Tyr Ser Arg Ser Leu Ala Leu Leu Ile Gly Val Ala Leu Leu Val
450 455 460Gly Val Phe Tyr Leu Leu Lys Lys Phe Tyr Gly Glu Asn Leu Lys Thr465 470 475 480
(2) Sequence 463 data:
(i) sequence characteristics:
(A) length: 629bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 82...525
(D) Other information:
(xi) Description of the sequence: sequence 463: CAAATCTCTA AAGAGTAACG CTTTTTAAAA AAATACATTT TTTTTAATTT TTTAATCAAT 60CATTAAGGTG TTTTAAGTTA A ATT TCC TTA TCT GTT AAA CAT ACG GAT AAT 111
Ile Ser Leu Ser Val Lys His Thr Asp Asn
1 5 10GTT ATA TCT TTA AGG AAA GAA AAT GGG GTT AGG ACA CTA ATA AGT TTA 159Val Ile Ser Leu Arg Lys Glu Asn Gly Val Arg Thr Leu Ile Ser Leu
15 20 25GGG ATT TTG TTA AGC GTT TTG AGT GGC GAT GAT CTG AAG TTG TAT TCA 207Gly Ile Leu Leu Ser Val Leu Ser Gly Asp Asp Leu Lys Leu Tyr Ser
30 35 40AAA CTT TCA GTC TAT TCG GCT GGA AGT GGG ATG ATT GGG ATT GAT ATT 255Lys Leu Ser Val Tyr Ser Ala Gly Ser Gly Met Ile Gly lle Asp Ile
45 50 55GAC AAA CGG ACA TTT TAT AAG CGA GCG TTC GCT TTC ACG ATG AAA TCG 303Asp Lys Arg Thr Phe Tyr Lys Arg Ala Phe Ala Phe Thr Met Lys Ser
60 65 70TTG TTC GGT GAA AAC TTG CTT TTG TTT GTCAAA TTA AAG CAT TCT GCG 351Leu Phe Gly Glu Asn Leu Leu Leu Phe Val Lys Leu Lys His Ser Ala75 80 85 90TTG ACG AGC AAA CAC ATG AAA GGG CCT TTA GAA AAC CGC CAT CAC CAT 399Leu Thr Ser Lys His Met Lys Gly Pro Leu Glu Asn Arg His His His
95 100 105TCT TTC ACT AAA AAT TAT GAA AAA GCG GTT AAT GGT TGT CAA AAG TAT 447Ser Phe Thr Lys Asn Tyr Glu Lys Ala Val Asn Gly Cys Gln Lys Tyr
110 115 120TTC CAT ATT AAA TTG CCT GAA GGC GCT CCT AGC AAC TTC AAA TCA GGT 495Phe His Ile Lys Leu Pro Glu Gly Ala Pro Ser Asn Phe Lys Ser Gly
125 130 135TCA TAC ATG GCC ACT ATG GTG GTG CGT TTT TAAAGCGTTA TTTGGGGTAT TCT 548Ser Tyr Met Ala Thr Met Val Val Arg Phe
140 145TTAATACCCT TATCGTCTTT TAAAATACCA TCTTTTAAAA GCACAAATTT ATTTTTTAGC 608CCTTTTTTAA ATCTTCTTAA A 629
(2) Sequence 464 data:
(i) sequence characteristics:
(A) length: 148 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 464: ile Ser Leu Ser Val Lys His Thr Asp Asn Val Ile Ser Leu Arg Lys 151015 Glu Asn Gly Val Arg Thr Leu Ile Ser Leu Gly Ile Leu Leu Ser Val
20 25 30Leu Ser Gly Asp Asp Leu Lys Leu Tyr Ser Lys Leu Ser Val Tyr Ser
35 40 45Ala Gly Ser Gly Met Ile Gly Ile Asp Ile Asp Lys Arg Thr Phe Tyr
50 55 60Lys Arg Ala Phe Ala Phe Thr Met Lys Ser Leu Phe Gly Glu Asn Leu65 70 75 80Leu Leu Phe Val Lys Leu Lys His Ser Ala Leu Thr Ser Lys His Met
85 90 95Lys Gly Pro Leu Glu Asn Arg His His His Ser Phe Thr Lys Asn Tyr
100 105 110Glu Lys Ala Val Asn Gly Cys Gln Lys Tyr Phe His Ile Lys Leu Pro
115 120 125Glu Gly Ala Pro Ser Asn Phe Lys Ser Gly Ser Tyr Met Ala Thr Met
130 135 140Val Val Arg Phe145
(2) Sequence 465 data:
(i) sequence characteristics:
(A) length: 626bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 98...547
(D) Other information:
(xi) Description of the sequence: sequence 465: ATGATTGTGC ACAGGAAGGA TTTGAAGAAG ACTTTGAGCG ATCTCATCGC TATGATGACG 60CATAAGACTT CAAAGATTTT TTAAAGTTTT AACATTG ATG CGT TGC GTG GTG TAT 115
Met Arg Cys Val Val Tyr
1 5TCT ATC GCT AAA AGT TCG CCT TTA GAG TTA GTG AAA ATC TAT CAA AAG 163Ser Ile Ala Lys Ser Ser Pro Leu Glu Leu Val Lys Ile Tyr Gln Lys
10 15 20CAA TGC AGG CAA TTT GAT TGC GAG CTG GAA TTG GTG GAT TTA TTC CCT 211Gln Cys Arg Gln Phe Asp Cys Glu Leu Glu Leu Val Asp Leu Phe Pro
25 30 35AAA AAT ACC GCC AAC GCT CAA AAA GTT TCT AAA AAA CTG GCT CAA AAA 259Lys Asn Thr Ala Asn Ala Gln Lys Val Ser Lys Lys Leu Ala Gln Lys
40 45 50AGC TAC TCT CTA GCT TTT GAG CCG TAT TTA AAC CCT AAG GCA AAA AAT 307Ser Tyr Ser Leu Ala Phe Glu Pro Tyr Leu Asn Pro Lys Ala Lys Asn55 60 65 70ATC GCC TTA CAC CCT AAA GCT CAA AGG GGC GAT AGC TTT GCG TTT AGT 355Ile Ala Leu His Pro Lys Ala Gln Arg Gly Asp Ser Phe Ala Phe Ser
75 80 85AAA ATG TTA GAA AAT CAT CTT AAT ATT AAT TTT TTT ATC GCT GGA GCG 403Lys Met Leu Glu Asn His Leu Asn Ile Asn Phe Phe Ile Ala Gly Ala
90 95 100TAT GGG TTT GAA GAA AAT TTT TTA AAG GAT TGT CAA GCT TGG AGT TTG 451Tyr Gly Phe Glu Glu Asn Phe Leu Lys Asp Cys Gln Ala Trp Ser Leu
105 110 115AGC GAG ATG ACT TTT AGC CAT GAA GTG GCT AAA ATT GTC TTA TGC GAG 499Ser Glu Met Thr Phe Ser His Glu Val Ala Lys Ile Val Leu Cys Glu
120 125 130CAA ATC TAT AGG GCT TTA AGC ATT ATT TTT AAG CAT CCA TAC CAT AAA T 548Gln Ile Tyr Arg Ala Leu Ser Ile Ile Phe Lys His Pro Tyr His Lys135 140 145 150AGGAGGTGCG CATGCGTTTT TACATTATCT TTACATTTTT GTTTATTGTG GGTTTTGGTG 608TGTTTGTTTA TAGTATTG 626
(2) Data for sequence 466:
(i) sequence characteristics:
(A) length: 150 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 466: met Arg Cys Val Val Tyr Ser Ile Ala Lys Ser Ser Pro Leu Glu Leu 151015 Val Lys Ile Tyr Gln Lys Gln Cys Arg Gln Phe Asp Cys Glu Leu Glu
20 25 30Leu Val Asp Leu Phe Pro Lys Asn Thr Ala Asn Ala Gln Lys Val Ser
35 40 45Lys Lys Leu Ala Gln Lys Ser Tyr Ser Leu Ala Phe Glu Pro Tyr Leu
50 55 60Asn Pro Lys Ala Lys Asn Ile Ala Leu His Pro Lys Ala Gln Arg Gly65 70 75 80Asp Ser Phe Ala Phe Ser Lys Met Leu Glu Asn His Leu Asn Ile Asn
85 90 95Phe Phe Ile Ala Gly Ala Tyr Gly Phe Glu Glu Asn Phe Leu Lys Asp
100 105 110Cys Gln Ala Trp Ser Leu Ser Glu Met Thr Phe Ser His Glu Val Ala
115 120 125Lys Ile Val Leu Cys Glu Gln Ile Tyr Arg Ala Leu Ser Ile Ile Phe
130 135 140Lys His Pro Tyr His Lys145 150
(2) Sequence 467 data:
(i) sequence characteristics:
(A) length: 1053bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 110...976
(D) Other information:
(xi) Description of the sequence: sequence 467: CTTTGTGTTT GTAAAAGAAA CCCTTGCATC ACTACTCTTA AGCTAATTTT GTTTATTATA 60AGCAAAACTT GGATACAATC CTAACAAAAC TGCAAAATTA AGGAAAAAC ATG GGA TTT 118
Met Gly Phe
1GCA GAT TTC TTT AAA AAT TTT AAG ATC AAT AAA TTG CGG ACA GCG CCA 166Ala Asp Phe Phe Lys Asn Phe Lys Ile Asn Lys Leu Arg Thr Ala Pro
5 10 15AGT AAG GAA GAA CAG CCA AGC CAT TGG GTG AAA TGC CCT AAA TGT TAT 214Ser Lys Glu Glu Gln Pro Ser His Trp Val Lys Cys Pro Lys Cys Tyr20 25 30 35GCG TTA ATG TAT CAT AAA GAA GTG TTT AGT AAA TAC AGC GTG TGT TTG 262Ala Leu Met Tyr His Lys Glu Val Phe Ser Lys Tyr Ser Val Cys Leu
40 45 50AAA TGC CAT TAC CAT TTC CGC ATG AAA GCG GCT GAA AGG ATT GAA TTT 310Lys Cys His Tyr His Phe Arg Met Lys Ala Ala Glu Arg Ile Glu Phe
55 60 65TTA TGC GAT GTG GGG AGT TTT GAA GAG TTT GAC AAG CAT TTA CGG CCT 358Leu Cys Asp Val Gly Ser Phe Glu Glu Phe Asp Lys His Leu Arg Pro
70 75 80AAT GAT CCT TTA AAT TTC GTG GAT AAA GAG AGC TAT AAA CAA CGC ATT 406Asn Asp Pro Leu Asn Phe Val Asp Lys Glu Ser Tyr Lys Gln Arg Ile
85 90 95AAA AAA TAC GAA AAA AGG ACT AAC CGC CCA AGC TCA GTG ATC AGC GGT 454Lys Lys Tyr Glu Lys Arg Thr Asn Arg Pro Ser Ser Val Ile Ser Gly100 105 110 115GAG GCT AAA ATC AAC CGC ATG CCT TTG CAG ATC GTG GTG TTT GAT TTT 502Glu Ala Lys Ile Asn Arg Met Pro Leu Gln Ile Val Val Phe Asp Phe
120 125 130AGC TTT ATG GGG GGG AGT TTA GGC TCT GTG GAG GGC GAA AAG ATC GTA 550Ser Phe Met Gly Gly Ser Leu Gly Ser Val Glu Gly Glu Lys Ile Val
135 140 145AGA GCA ATC AAT CGC GCG GTC GCT AAA AGA GAA GCG TTA TTG ATT GTT 598Arg Ala Ile Asn Arg Ala Val Ala Lys Arg Glu Ala Leu Leu Ile Val
150 155 160TCA GCG AGT GGG GGG GCT AGG ATG CAA GAA TCC ACT TAT TCG CTC ATG 646Ser Ala Ser Gly Gly Ala Arg Met Gln Glu Ser Thr Tyr Ser Leu Met
165 170 175CAA ATG GCT AAA ACG AGC GCG GCT TTG AAC CGA TTG AGT GAG GCC AAA 694Gln Met Ala Lys Thr Ser Ala Ala Leu Asn Arg Leu Ser Glu Ala Lys180 185 190 195CTC CCT TTC ATT TCG CTC TTA AGC GAT CCC ACT TAT GGG GGC GTT AGC 742Leu Pro Phe Ile Ser Leu Leu Ser Asp Pro Thr Tyr Gly Gly Val Ser
200 205 210GCA TCT TTT GCT TTT TTA GGG GAT CTC ATT ATC GCA GAG CCA GGG GCG 790Ala Ser Phe Ala Phe Leu Gly Asp Leu Ile Ile Ala Glu Pro GlyAla
215 220 225ATG ATA GGC TTT GCG GGG CCT AGG GTG ATT AAG CAA ACT ATA GGG GCG 838Met Ile Gly Phe Ala Gly Pro Arg Val Ile Lys Gln Thr Ile Gly Ala
230 235 240GAT TTG CCT GAG GGC TTT CAA ACA GCG GAA TTT TTA TTA GAG CAT GGC 886Asp Leu Pro Glu Gly Phe Gln Thr Ala Glu Phe Leu Leu Glu His Gly
245 250 255TTG ATT GAT ATG ATT GTG CAC AGG AAG GAT TTG AAG AAG ACT TTG AGC 934Leu Ile Asp Met Ile Val His Arg Lys Asp Leu Lys Lys Thr Leu Ser260 265 270 275GAT CTC ATC GCT ATG ATG ACG CAT AAG ACT TCA AAG ATT TTT TAAAGTTTT 985Asp Leu Ile Ala Met Met Thr His Lys Thr Ser Lys Ile Phe
280 285AACATTGATG CGTTGCGTGG TGTATTCTAT CGCTAAAAGT TCGCCTTTAG AGTTAGTGAA 1045AATCTATC 1053
(2) Data of sequence 468:
(i) sequence characteristics:
(A) length: 289 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 468: met Gly Phe Ala Asp Phe Phe Lys Asn Phe Lys Ile Asn Lys Leu Arg 151015 Thr Ala Pro Ser Lys Glu Glu Gln Pro Ser His Trp Val Lys Cys Pro
20 25 30Lys Cys Tyr Ala Leu Met Tyr His Lys Glu Val Phe Ser Lys Tyr Ser
3540 45Val Cys Leu Lys Cys His Tyr His Phe Arg Met Lys Ala Ala Glu Arg
50 55 60Ile Glu Phe Leu Cys Asp Val Gly Ser Phe Glu Glu Phe Asp Lys His65 70 75 80Leu Arg Pro Asn Asp Pro Leu Asn Phe Val Asp Lys Glu Ser Tyr Lys
85 90 95Gln Arg Ile Lys Lys Tyr Glu Lys Arg Thr Asn Arg Pro Ser Ser Val
100 105 110Ile Ser Gly Glu Ala Lys Ile Asn Arg Met Pro Leu Gln Ile Val Val
115 120 125Phe Asp Phe Ser Phe Met Gly Gly Ser Leu Gly Ser Val Glu Gly Glu
130 135 140Lys Ile Val Arg Ala Ile Asn Arg Ala Val Ala Lys Arg Glu Ala Leu145 150 155 160Leu Ile Val Ser Ala Ser Gly Gly Ala Arg Met Gln Glu Ser Thr Tyr
165 170 175Ser Leu Met Gln Met Ala Lys Thr Ser Ala Ala Leu Asn Arg Leu Ser
180 185 190Glu Ala Lys Leu Pro Phe Ile Ser Leu Leu Ser Asp Pro Thr Tyr Gly
195 200 205Gly Val Ser Ala Ser Phe Ala Phe Leu Gly Asp Leu Ile Ile Ala Glu
210 215 220Pro Gly Ala Met Ile Gly Phe Ala Gly Pro Arg Val Ile Lys Gln Thr225 230 235 240Ile Gly Ala Asp Leu Pro Glu Gly Phe Gln Thr Ala Glu Phe Leu Leu
245 250 255Glu His Gly Leu Ile Asp Met Ile Val His Arg Lys Asp Leu Lys Lys
260265 270Thr Leu Ser Asp Leu Ile Ala Met Met Thr His Lys Thr Ser Lys Ile
275 280 285Phe
(2) Data for sequence 469:
(i) sequence characteristics:
(A) length: 810bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 95...706
(D) Other information:
(xi) Description of the sequence: sequence 469: TCTGCAAATC CCATGTTTTT CCTTAATTTT GCAGTTTTGT TAGGATTGTA TCCAAGTTTT 60GCTTATAATA AACAAAATTA GCTTAAGAGT AGTG ATG CAA GGG TTT CTT TTA CAA 115
Met Gln Gly Phe Leu Leu Gln
1 5ACA CAA AGC ATA AGA GAT GAA GAT TTG ATC GTG CGC GTT TTA ACC AAA 163Thr Gln Ser Ile Arg Asp Glu Asp Leu Ile Val Arg Val Leu Thr Lys
10 15 20AAC CAG CTC AAA ACC CTC TAT CGT TTC TAT GGC AAA CGC CAT AGC GTG 211Asn Gln Leu Lys Thr Leu Tyr Arg Phe Tyr Gly Lys Arg His Ser Val
25 30 35CTG AAT GTG GGG CGT AAA ATT GAT TTT GAA GAA GAA AAC GAT GAT AAG 259Leu Asn Val Gly Arg Lys Ile Asp Phe Glu Glu Glu Asn Asp Asp Lys40 45 50 55TTT TTA CCC AAG TTA AGG AAT ATT TTG CAT TTA GGC TAT ATT TGG GAA 307PheLeu Pro Lys Leu Arg Asn Ile Leu His Leu Gly Tyr Ile Trp Glu
60 65 70AGA GAA ATG GAG CGC TTG TTT TTT TGG CAA CGC TTT TGC GCT CTC TTG 355Arg Glu Met Glu Arg Leu Phe Phe Trp Gln Arg Phe Cys Ala Leu Leu
75 80 85TTT AGG CAT TTA GAA GGC GTG CAT TCT TTA GAT AGC GTC TAT TTT GAC 403Phe Arg His Leu Glu Gly Val His Ser Leu Asp Ser Val Tyr Phe Asp
90 95 100ACT TTA GAT GAT GGG GCT AAC AAA CTC GCC AAA CAG CAC CCC TTA AGA 451Thr Leu Asp Asp Gly Ala Asn Lys Leu Ala Lys Gln His Pro Leu Arg
105 110 115GTG ATT TTA GAA ATG TAT GCA ACG CTT TTG AAT TTT GAA GGG CGC TTG 499Val Ile Leu Glu Met Tyr Ala Thr Leu Leu Asn Phe Glu Gly Arg Leu120 125 130 135CAA AGT TAC AAT TCT TGT TTT TTA TGC GAT GCA AAA TTA GAG CGT TCT 547Gln Ser Tyr Asn Ser Cys Phe Leu Cys Asp Ala Lys Leu Glu Arg Ser
140 145 150GTC GCT TTA GCG CAA GGG TTT ATT CTA GCG CAC CCC TCT TGT TTG AAA 595Val Ala Leu Ala Gln Gly Phe Ile Leu Ala His Pro Ser Cys Leu Lys
155 160 165GCT AAA AGC CTA AAT TTA GAA AAA ATC CAA GCT TTT TTT CGC ACT CAA 643Ala Lys Ser Leu Asn Leu Glu Lys Ile Gln Ala Phe Phe Arg Thr Gln
170 175 180AGC ACG ATT GAT TTA GAA ACA GAA GAA GTA GAA GAA TTA TGG CGC ACG 691Ser Thr Ile Asp Leu Glu Thr Glu Glu Val Glu Glu Leu Trp Arg Thr
185 190 195CTG AAT TTA GGG TTT TGAAAGGTTA AAAATGAAAT TTAAATTTTT GAATATGGAT A 747Leu Asn Leu Gly Phe200ATGAAAGCGG TTTTATTTTG ATTGAAAAAG AATTGAAACG ATTAAACATT CTCGCTCAAG 807TCA 810
(2) Sequence 470 data:
(i) sequence characteristics:
(A) length: 204 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 470: met Gln Gly Phe Leu Leu Gln Thr Gln Ser Ile Arg Asp Glu Asp Leu 151015 Ile Val Arg Val Leu Thr Lys Asn Gln Leu Lys Thr Leu Tyr Arg Phe
20 25 30Tyr Gly Lys Arg His Ser Val Leu Asn Val Gly Arg Lys Ile Asp Phe
35 40 45Glu Glu Glu Asn Asp Asp Lys Phe Leu Pro Lys Leu Arg Asn Ile Leu
50 55 60His Leu Gly Tyr Ile Trp Glu Arg Glu Met Glu Arg Leu Phe Phe Trp65 70 75 80Gln Arg Phe Cys Ala Leu Leu Phe Arg His Leu Glu Gly Val His Ser
85 90 95Leu Asp Ser Val Tyr Phe Asp Thr Leu Asp Asp Gly Ala Asn Lys Leu
100 105 110Ala Lys Gln His Pro Leu Arg Val Ile Leu Glu Met Tyr Ala Thr Leu
115 120 125Leu Asn Phe Glu Gly Arg Leu Gln Ser Tyr Asn Ser Cys Phe Leu Cys
130 135 140Asp Ala Lys Leu Glu Arg Ser Val Ala Leu Ala Gln Gly Phe Ile Leu145 150155 160Ala His Pro Ser Cys Leu Lys Ala Lys Ser Leu Asn Leu Glu Lys Ile
165 170 175Gln Ala Phe Phe Arg Thr Gln Ser Thr Ile Asp Leu Glu Thr Glu Glu
180 185 190Val Glu Glu Leu Trp Arg Thr Leu Asn Leu Gly Phe
195 200
(2) Sequence 471 data:
(i) sequence characteristics:
(A) length: 999bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 76...927
(D) Other information:
(xi) Description of the sequence: sequence 471: GCACATAAAA TCGCGCTACT AGGGTATGAA TTTGAAGCGA TCGCTCCTAA AGAATTTGAA 60ATTTAAGGAT TGATC ATG AAC GCT TGG AAT ACG ATT TAT GAT CAA TTT AAC 111
Met Asn Ala Trp Asn Thr Ile Tyr Asp Gln Phe Asn
1 5 10CCT ATC GCT TTT AGT CTT GGC AGT ATT GAA GTG CAT TGG TAT GGT TTG 159Pro Ile Ala Phe Ser Leu Gly Ser Ile Glu Val His Trp Tyr Gly Leu
15 20 25GCG TAT GCG TGT GCG ATT GTT ACC GCT TTT TAT ATG GCG TTA AGA ATG 207Ala Tyr Ala Cys Ala Ile Val Thr Ala Phe Tyr Met Ala Leu Arg Met
30 35 40ATC CAA AAA GAC CCCAAG CGA TTC CCC ATT GAA AGG AAG GAA TTT GAG 255Ile Gln Lys Asp Pro Lys Arg Phe Pro Ile Glu Arg Lys Glu Phe Glu45 50 55 60AGT TAT TTT TTA TGG GCG GAG CTT GGC ATT GTG CTA GGG GCA AGG ATA 303Ser Tyr Phe Leu Trp Ala Glu Leu Gly Ile Val Leu Gly Ala Arg Ile
65 70 75GGA TAC ATT CTT ATT TAT GAG CCT AAT TCT GGC TAT TAT TTG ACG CAT 351Gly Tyr Ile Leu Ile Tyr Glu Pro Asn Ser Gly Tyr Tyr Leu Thr His
80 85 90TTT TGG CAA ATC TTT AAC CCT TTT GAT AGC CAT GGG AAT TTT GTA GGC 399Phe Trp Gln Ile Phe Asn Pro Phe Asp Ser His Gly Asn Phe Val Gly
95 100 105ATT CGT GGG ATG AGC TAT CAT GGG GGG TTG GTG GGG TTT TTG ATC GCT 447Ile Arg Gly Met Ser Tyr His Gly Gly Leu Val Gly Phe Leu Ile Ala
110 115 120TCG TAT CTT TAT AGC CGT AAG GAT TTG AAA AAG CTT TTG ATT TAT TTG 495Ser Tyr Leu Tyr Ser Arg Lys Asp Leu Lys Lys Leu Leu Ile Tyr Leu125 130 135 140GAT TTG ATT GCG ATC AGC CTG CCT TTA GGG TAT GTT TTT GGG AGG ATT 543Asp Leu Ile Ala Ile Ser Leu Pro Leu Gly Tyr Val Phe Gly Arg Ile
145 150 155GGG AAT TTT TTA AAC CAG GAG CTT GTG GGA AGA ATT GTC CCC AAA GAC 591Gly Asn Phe Leu Asn Gln Glu Leu Val Gly Arg Ile Val Pro Lys Asp
160 165 170AGC CAT TTA GGG CAA ATC ATA GGC ATT ATG GTG GAT AAT GAG TTG CGT 639Ser His Leu Gly Gln Ile Ile Gly Ile Met Val Asp Asn Glu Leu Arg
175 180 185TAT CCC AGC CAA TTG ATT GAA GCG TTT TTA GAG GGG GTT ATC GTG TTT 687Tyr Pro Ser Gln Leu Ile GluAla Phe Leu Glu Gly Val Ile Val Phe
190 195 200TTA ATG GTA ATG TGG GCT AAA AAA CAC ACC AAA ACG CAT GGG TTG CTG 735Leu Met Val Met Trp Ala Lys Lys His Thr Lys Thr His Gly Leu Leu205 210 215 220ATT GTG GTT TAT GGT TTG GGG TAT TCC TTG ATG CGC TTT ATT GCG GAA 783Ile Val Val Tyr Gly Leu Gly Tyr Ser Leu Met Arg Phe Ile Ala Glu
225 230 235TTT TAC AGA GAG CCG GAC AGC CAA ATG GGG GTT TAT TTT TTA AAT TTG 831Phe Tyr Arg Glu Pro Asp Ser Gln Met Gly Val Tyr Phe Leu Asn Leu
240 245 250AGC ATG GGG CAG ATT TTA AGC TTA TTT ATG GTA ATT GTT TCG TTA GGG 879Ser Met Gly Gln Ile Leu Ser Leu Phe Met Val Ile Val Ser Leu Gly
255 260 265ATT TTA TTG TAT GCT ACA AAA AAT TCT AAA AAA ATA AAG GAA AAT CAA T 928Ile Leu Leu Tyr Ala Thr Lys Asn Ser Lys Lys Ile Lys Glu Asn Gln
270 275 280GAAATTTTTG GATCAAGAAA AAAGAAGACA ATTATTAAAC GAGCGCCATT CTTGCAAGAT 988GTTTGATAGC C 999
(2) Sequence 472 data:
(i) sequence characteristics:
(A) length: 284 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 472: met Asn Ala Trp Asn Thr Ile Tyr Asp Gln Phe Asn Pro Ile Ala Phe 151015 Ser Leu Gly Ser Ile Glu Val His Trp Tyr Gly Leu Ala Tyr Ala Cys
20 25 30Ala Ile Val Thr Ala Phe Tyr Met Ala Leu Arg Met Ile Gln Lys Asp
35 40 45Pro Lys Arg Phe Pro Ile Glu Arg Lys Glu Phe Glu Ser Tyr Phe Leu
50 55 60Trp Ala Glu Leu Gly Ile Val Leu Gly Ala Arg Ile Gly Tyr Ile Leu65 70 75 80Ile Tyr Glu Pro Asn Ser Gly Tyr Tyr Leu Thr His Phe Trp Gln Ile
85 90 95Phe Asn Pro Phe Asp Ser His Gly Asn Phe Val Gly Ile Arg Gly Met
100 105 110Ser Tyr His Gly Gly Leu Val Gly Phe Leu Ile Ala Ser Tyr Leu Tyr
115 120 125Ser Arg Lys Asp Leu Lys Lys Leu Leu Ile Tyr Leu Asp Leu Ile Ala
130 135 140Ile Ser Leu Pro Leu Gly Tyr Val Phe Gly Arg Ile Gly Asn Phe Leu145 150 155 160Asn Gln Glu Leu Val Gly Arg Ile Val Pro Lys Asp Ser His Leu Gly
165 170 175Gln Ile Ile Gly Ile Met Val Asp Asn Glu Leu Arg Tyr Pro Ser Gln
180 185 190Leu Ile Glu Ala Phe Leu Glu Gly Val Ile Val Phe Leu Met Val Met
195 200 205Trp Ala Lys Lys His Thr Lys Thr His Gly Leu Leu Ile Val Val Tyr
210 215 220Gly Leu Gly Tyr Ser Leu Met Arg Phe Ile Ala Glu Phe Tyr Arg Glu225 230 235 240Pro Asp Ser Gln Met Gly Val Tyr Phe Leu Asn Leu Ser Met Gly Gln
245 250 255Ile Leu Ser Leu Phe Met Val Ile Val Ser Leu Gly Ile Leu Leu Tyr
260 265 270Ala Thr Lys Asn Ser Lys Lys Ile Lys Glu Asn Gln
275 280
(2) Sequence 473 data:
(i) sequence characteristics:
(A) length: 1104bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 86...994
(D) Other information:
(xi) Description of the sequence: sequence 473: AGCGAATTAG CCTTGCTTTT AAAGGGTAAG AGTGTGCTAG AGAGCATGAA CGATTTGATC 60AGACGCGCTT AAAAGGAAAG AGAGC ATG CAA GAT TTT TCA AGT TTA TTA TTA 112
Met Gln Asp Phe Ser Ser Leu Leu Leu
1 5AAA CTA CAA GAG TAT TGG AAG AAT CAA GGC TGT TTG GTG ATC CAG CCT 160Lys Leu Gln Glu Tyr Trp Lys Asn Gln Gly Cys Leu Val Ile Gln Pro10 15 20 25TAT GAT ATT CCT GCA GGA GCT GGG ACA TTC CAT CCG GCC ACG CTT TTA 208Tyr Asp Ile Pro Ala Gly Ala Gly Thr Phe His Pro Ala Thr Leu Leu
30 35 40ACG AGT TTG GAT AAA AAG CCG TGG AAT GTG GCG TAT GTC GCG CCC TCT256Arg Ser Leu Asp Lys Lys Pro Trp Asn Val Ala Tyr Val Ala Pro Ser
45 50 55AGA AGG CCT ACT GAT GGG CGC TAT GGG GAA AAC CCT AAC CGC TTG GGG 304Arg Arg Pro Thr Asp Gly Arg Tyr Gly Glu Asn Pro Asn Arg Leu Gly
60 65 70AGT TAT TAC CAA TTC CAA GTA GTC ATC AAG CCC AGC CCT TCT AAT ATC 352Ser Tyr Tyr Gln Phe Gln Val Val Ile Lys Pro Ser Pro Ser Asn Ile
75 80 85CAG GAA CTC TAT TTA AAA AGC TTA GAA GTG TTA GGG ATA AAC CTT AAT 400Gln Glu Leu Tyr Leu Lys Ser Leu Glu Val Leu Gly Ile Asn Leu Asn90 95 100 105GAG CAT GAT ATA CGA TTT GTA GAA GAC AAT TGG GAG AGT CCG ACT TTA 448Glu His Asp Ile Arg Phe Val Glu Asp Asn Trp Glu Ser Pro Thr Leu
110 115 120GGG GCA TGG GGG CTT GGC TGG GAA GTG TGG CTT GAT GGC ATG GAA GTT 496Gly Ala Trp Gly Leu Gly Trp Glu Val Trp Leu Asp Gly Met Glu Val
125 130 135ACG CAA TTC ACT TAT TTC CAG CAA GTG GGG GGC ATT GCT TGT AGC CCT 544Thr Gln Phe Thr Tyr Phe Gln Gln Val Gly Gly Ile Ala Cys Ser Pro
140 145 150ATT CCT GTA GAG ATC ACT TAC GGC TTA GAA AGA TTA GCG ATG TAT GTG 592Ile Pro Val Glu Ile Thr Tyr Gly Leu Glu Arg Leu Ala Met Tyr Val
155 160 165CAA AAA GTG GAA AAT ATC CTA GAG ATT GAA TGG GCT AAA AAA AAT CAT 640Gln Lys Val Glu Asn Ile Leu Glu Ile Glu Trp Ala Lys Lys Asn His170 175 180 185GAC AGC GTG AAT TAC GCA CAA GTG CAT TTG GAA AGC GAA TAC GAA TTC 688Asp Ser Val Asn Tyr Ala Gln Val His Leu Glu Ser Glu Tyr Glu Phe
190 195 200AGC AAG TAT CAT TTT GAA ACA GCG AGC GTG AAA CGG CTA TTA GAA ATG 736Ser Lys Tyr His Phe Glu Thr Ala Ser Val Lys Arg Leu Leu Glu Met
205 210 215TTT AAA AAC GCT CAA GCC GAA GCC TTG CAT TGC TTG GAA AAC AAG CTC 784Phe Lys Asn Ala Gln Ala Glu Ala Leu His Cys Leu Glu Asn Lys Leu
220 225 230CCC TTG CCG GCT TAT GAT TTT GTG ATG TTA TGC TCG CAT TTT TTC AAT 832Pro Leu Pro Ala Tyr Asp Phe Val Met Leu Cys Ser His Phe Phe Asn
235 240 245ATT TTA GAC GCC AGA AAA GCG ATT TCG GTG GCT GAA AGG CAA AAT TAT 880Ile Leu Asp Ala Arg Lys Ala Ile Ser Val Ala Glu Arg Gln Asn Tyr250 255 260 265ATT TTA CAA ATC AGG GAT TTA GCC AAA GGG TGT GCG CTT CTT TAT AAA 928Ile Leu Gln Ile Arg Asp Leu Ala Lys Gly Cys Ala Leu Leu Tyr Lys
270 275 280GAA CAA GAA GAA GAG AGG GAA GAG CGT TTA AAA AAC GCT TTA ACA AAG 976Glu Gln Glu Glu Glu Arg Glu Glu Arg Leu Lys Asn Ala Leu Thr Lys
285 290 295GCT GAA AAT GGC GTT AGT TAAGGAAGTG TTGGTAGTTT TGAATCGCCT TTCGCCTT 1032Ala Glu Asn Gly Val Ser
300TTGAACTCCA AGAATCATGG GATAATAGCG GGTTGAATGT GGGGAGTGAA AATAGTGAAT 1092TTAGCGAGAT TG 1104
(2) Sequence 474 data:
(i) sequence characteristics:
(A) length: 303 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 474: met Gln Asp Phe Ser Ser Leu Leu Leu Lys Leu Gln Glu Tyr Trp Lys 151015 Asn Gln Gly Cys Leu Val Ile Gln Pro Tyr Asp Ile Pro Ala Gly Ala
20 25 30Gly Thr Phe His Pro Ala Thr Leu Leu Arg Ser Leu Asp Lys Lys Pro
35 40 45Trp Asn Val Ala Tyr Val Ala Pro Ser Arg Arg Pro Thr Asp Gly Arg
50 55 60Tyr Gly Glu Asn Pro Asn Arg Leu Gly Ser Tyr Tyr Gln Phe Gln Val65 70 75 80Val Ile Lys Pro Ser Pro Ser Asn Ile Gln Glu Leu Tyr Leu Lys Ser
85 90 95Leu Glu Val Leu Gly Ile Asn Leu Asn Glu His Asp Ile Arg Phe Val
100 105 110Glu Asp Asn Trp Glu Ser Pro Thr Leu Gly Ala Trp Gly Leu Gly Trp
115 120 125Glu Val Trp Leu Asp Gly Met Glu Val Thr Gln Phe Thr Tyr Phe Gln
130 135 140Gln Val Gly Gly Ile Ala Cys Ser Pro Ile Pro Val Glu Ile Thr Tyr145 150 155 160Gly Leu Glu Arg Leu Ala Met Tyr Val Gln Lys Val Glu Asn lle Leu
165 170 175Glu Ile Glu Trp Ala Lys Lys Asn His Asp Ser Val Asn Tyr Ala Gln
180 185 190Val His Leu Glu Ser Glu Tyr Glu Phe Ser Lys Tyr His Phe Glu Thr
195 200205Ala Ser Val Lys Arg Leu Leu Glu Met Phe Lys Asn Ala Gln Ala Glu
210 215 220Ala Leu His Cys Leu Glu Asn Lys Leu Pro Leu Pro Ala Tyr Asp Phe225 230 235 240Val Met Leu Cys Ser His Phe Phe Asn Ile Leu Asp Ala Arg Lys Ala
245 250 255Ile Ser Val Ala Glu Arg Gln Asn Tyr Ile Leu Gln Ile Arg Asp Leu
260 265 270Ala Lys Gly Cys Ala Leu Leu Tyr Lys Glu Gln Glu Glu Glu Arg Glu
275 280 285Glu Arg Leu Lys Asn Ala Leu Thr Lys Ala Glu Asn Gly Val Ser
290 295 300
(2) Sequence 475 data:
(i) sequence characteristics:
(A) length: 1620bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 66...1538
(D) Other information:
(xi) Description of the sequence: sequence 475: GGCAAAGGAA TGCGATTTTA GCTAACCACA TCACTCTCAT GCAAGAGCTT TAAAAAGTCC 60TAAAA ATG GCG CAA AAA ACT CTT TTG ATT ATC ACT GAT GGC ATT GGG TAT 110
Met Ala Gln Lys Thr Leu Leu Ile Ile Thr Asp Gly Ile Gly Tyr
1 5 10 15CGT AAA GAT AGC GAT CAT AAC GCT TTC TTC CAT GCC AAA AAA CCC ACT 158Arg Lys Asp Ser Asp His Asn Ala Phe Phe His Ala Lys Lys Pro Thr
20 25 30TAT GAT TTG ATG TTT AAA ACC TTG CCT TAT AGC CTG ATT GAT ACG CAT 206Tyr Asp Leu Met Phe Lys Thr Leu Pro Tyr Ser Leu Ile Asp Thr His
35 40 45GGC TTG AGC GTG GGC TTA CCT AAG GGG CAA ATG GGA AAT TCT GAA GTG 254Gly Leu Ser Val Gly Leu Pro Lys Gly Gln Met Gly Asn Ser Glu Val
50 55 60GGG CAT ATG TGT ATT GGG GCT GGT AGG GTG CTC TAT CAG GAT TTA GTC 302Gly His Met Cys Ile Gly Ala Gly Arg Val Leu Tyr Gln Asp Leu Val
65 70 75AAA ATT TCT TTA AGC CTT CAA AAC GAT GAA TTA AAA AAC AAC CCC GCT 350Lys Ile Ser Leu Ser Leu Gln Asn Asp Glu Leu Lys Asn Asn Pro Ala80 85 90 95TTT TTA AAC ACG ATC CAA AAA AGC CCT GTG GTG CAT CTT ATG GGT TTA 398Phe Leu Asn Thr Ile Gln Lys Ser Pro Val Val His Leu Met Gly Leu
100 105 110ATG AGC GAT GGA GGC GTG CAT TCA CAC ATT GAG CAT TTT ATC GCT CTG 446Met Ser Asp Gly Gly Val His Ser His Ile Glu His Phe Ile Ala Leu
115 120 125GCT TTA GAG TGT GAA AAA TCC CAT AAA AAA GTC TGT CTG CAT TTA ATC 494Ala Leu Glu Cys Glu Lys Ser His Lys Lys Val Cys Leu His Leu Ile
130 135 140ACC GAT GGG CGC GAT GTC GCT CCT AAA AGC GCT TTA ACT TAT TTA AAA 542Thr Asp Gly Arg Asp Val Ala Pro Lys Ser Ala Leu Thr Tyr Leu Lys
145 150 155CAA ATG CAA AAT ATC TGC AAT GAA AGC ATT CAA ATC GCT ACC ATA AGC 590Gln Met Gln Asn Ile Cys Asn Glu Ser Ile Gln Ile Ala Thr Ile Ser160 165 170 175GGT CGT TTT TAT GCC ATG GAT AGG GAT AAG CGC TTT GAA AGG ATT GAG 638Gly Arg Phe Tyr Ala Met Asp Arg Asp Lys Arg Phe Glu Arg Ile Glu
180 185 190CTT GCG TAT CAT AGC TTA ATG GGG CTT AAT CAC ACG CCT TTA AGC CCT 686Leu Ala Tyr His Ser Leu Met Gly Leu Asn His Thr Pro Leu Ser Pro
195 200 205AGC GAG TAT ATC CAA AGC CAG TAT GAT AAA AAT ATC ACC GAT GAA TTT 734Ser Glu Tyr Ile Gln Ser Gln Tyr Asp Lys Asn Ile Thr Asp Glu Phe
210 215 220ATC ATG CCC GCT TGT TTT AAA AAT TAT TGC GGC ATG CAA GAT GAT GAG 782Ile Met Pro Ala Cys Phe Lys Asn Tyr Cys Gly Met Gln Asp Asp Glu
225 230 235AGT TTT ATT TTT ATC AAT TTC AGG AAT GAT AGG GCT AGA GAA ATC GTG 830Ser Phe Ile Phe Ile Asn Phe Arg Asn Asp Arg Ala Arg Glu Ile Val240 245 250 255AGC GCT TTA GGC CAA AAA CAA TTC AGT GGC TTT AAG CGC CAA GTT TTT 878Ser Ala Leu Gly Gln Lys Gln Phe Ser Gly Phe Lys Arg Gln Val Phe
260 265 270AAA AAA CTC CAT ATC GCT ACC ATG ACG CCT TAT GAT AAC ACT TTC CCC 926Lys Lys Leu His Ile Ala Thr Met Thr Pro Tyr Asp Asn Thr Phe Pro
275 280 285TAC CCT GTT TTA TTC CCC AAA GAA AGC GTT CAA AAC ACG CTC GCT GAA 974Tyr Pro Val Leu Phe Pro Lys Glu Ser Val Gln Asn Thr Leu Ala Glu
290 295 300GTG GTC TCT CAA CAC AAC CTG ACC CAA AGC CAT ATC GCT GAA ACT GAA 1022Val Val Ser Gln His Asn Leu Thr Gln Ser His Ile Ala Glu Thr Glu
305 310 315AAA TAC GCG CAT GTA ACC TTT TTC ATC AAT GGC GGA GTG GAG ACG CCT 1070Lys Tyr Ala His Val Thr Phe Phe Ile Asn Gly Gly Val Glu Thr Pro320 325 330 335TTT AAA AAT GAA AAC CGG GTG CTT ATC CAA AGC CCT AAA GTT ACC ACT 1118Phe Lys Asn Glu Asn Arg Val Leu Ile Gln Ser Pro Lys Val Thr Thr
340 345 350TAT GAC TTA AAG CCT GAA ATG AGC GCT AAA GAA GTA ACC CTT GCG GTG 1166Tyr Asp Leu Lys Pro Glu Met Ser Ala Lys Glu Val Thr Leu Ala Val
355 360 365TTA GAG CAA ATG AAA CTA GGC ACG GAT TTG ATC ATT GTG AAT TTT GCT 1214Leu Glu Gln Met Lys Leu Gly Thr Asp Leu Ile Ile Val Asn Phe Ala
370 375 380AAT GGC GAT ATG GTA GGG CAT ACG GGG AAT TTT GAA GCG AGC GTC AAA 1262Asn Gly Asp Met Val Gly His Thr Gly Asn Phe Glu Ala Ser Val Lys
385 390 395GCG GTG GAA GCA GTG GAT GCA TGT TTA GGG GAA ATC CTT TCA CTG GCT 1310Ala Val Glu Ala Val Asp Ala Cys Leu Gly Glu Ile Leu Ser Leu Ala400 405 410 415AAA AAA TTG GAT TAC GCC ATG CTT TTA ACC AGC GAT CAT GGG AAT TGC 1358Lys Lys Leu Asp Tyr Ala Met Leu Leu Thr Ser Asp His Gly Asn Cys
420 425 430GAG CGC ATG AAA GAC GAA AAC CAA AAC CCC TTA ACC AAC CAC ACC GCC 1406Glu Arg Met Lys Asp Glu Asn Gln Asn Pro Leu Thr Asn His Thr Ala
435 440 445GGG AGC GTG TAT TGC TTT GTT TTA GGG GAT GGA GTC AAA TCC ATA AAA 1454Gly Ser Val Tyr Cys Phe Val Leu Gly Asp Gly Val Lys Ser Ile Lys
450 455 460AAC GGA GCC TTA AAC AAT ATC GCT AGC AGC GTG TTA AAA CTC ATG GGC 1502Asn Gly Ala Leu Asn Asn Ile Ala Ser Ser Val Leu Lys Leu Met Gly
465 470 475CTT AAA GCC CCA GCA ACG ATG GAC GAA CCC CTA TTT TAAACTAAAG GAAAAG 1554Leu Lys Ala Pro Ala Thr Met Asp Glu Pro Leu Phe480 485 490AATGCAAATT GATGACGCAT TATTGCAACG CTTGGAAAAA TTGAGCATGC TAGAGATTAA 1614AGATGA 1620
(2) Sequence 476 data:
(i) sequence characteristics:
(A) length: 491 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 476: met Ala Gln Lys Thr Leu Leu Ile Ile Thr Asp Gly Ile Gly Tyr Arg 151015 Lys Asp Ser Asp His Asn Ala Phe Phe His Ala Lys Lys Pro Thr Tyr
20 25 30Asp Leu Met Phe Lys Thr Leu Pro Tyr Ser Leu Ile Asp Thr His Gly
35 40 45Leu Ser Val Gly Leu Pro Lys Gly Gln Met Gly Asn Ser Glu Val Gly
50 55 60His Met Cys Ile Gly Ala Gly Arg Val Leu Tyr Gln Asp Leu Val Lys65 70 75 80Ile Ser Leu Ser Leu Gln Asn Asp Glu Leu Lys Asn Asn Pro Ala Phe
85 90 95Leu Asn Thr Ile Gln Lys Ser Pro Val Val His Leu Met Gly Leu Met
100 105110Ser Asp Gly Gly Val His Ser His Ile Glu His Phe Ile Ala Leu Ala
115 120 125Leu Glu Cys Glu Lys Ser His Lys Lys Val Cys Leu His Leu Ile Thr
130 135 140Asp Gly Arg Asp Val Ala Pro Lys Ser Ala Leu Thr Tyr Leu Lys Gln145 150 155 160Met Gln Asn Ile Cys Asn Glu Ser Ile Gln Ile Ala Thr Ile Ser Gly
165 170 175Arg Phe Tyr Ala Met Asp Arg Asp Lys Arg Phe Glu Arg Ile Glu Leu
180 185 190Ala Tyr His Ser Leu Met Gly Leu Asn His Thr Pro Leu Ser Pro Ser
195 200 205Glu Tyr Ile Gln Ser Gln Tyr Asp Lys Asn Ile Thr Asp Glu Phe Ile
210 215 220Met Pro Ala Cys Phe Lys Asn Tyr Cys Gly Met Gln Asp Asp Glu Ser225 230 235 240Phe Ile Phe Ile Asn Phe Arg Asn Asp Arg Ala Arg Glu Ile Val Ser
245 250 255Ala Leu Gly Gln Lys Gln Phe Ser Gly Phe Lys Arg Gln Val Phe Lys
260 265 270Lys Leu His Ile Ala Thr Met Thr Pro Tyr Asp Asn Thr Phe Pro Tyr
275 280 285Pro Val Leu Phe Pro Lys Glu Ser Val Gln Asn Thr Leu Ala Glu Val
290 295 300Val Ser Gln His Asn Leu Thr Gln Ser His Ile Ala Glu Thr Glu Lys305 310 315 320Tyr Ala His Val Thr Phe Phe Ile Asn Gly Gly Val Glu Thr Pro Phe
325 330335Lys Asn Glu Asn Arg Val Leu Ile Gln Ser Pro Lys Val Thr Thr Tyr
340 345 350Asp Leu Lys Pro Glu Met Ser Ala Lys Glu Val Thr Leu Ala Val Leu
355 360 365Glu Gln Met Lys Leu Gly Thr Asp Leu Ile Ile Val Asn Phe Ala Asn
370 375 380Gly Asp Met Val Gly His Thr Gly Asn Phe Glu Ala Ser Val Lys Ala385 390 395 400Val Glu Ala Val Asp Ala Cys Leu Gly Glu Ile Leu Ser Leu Ala Lys
405 410 415Lys Leu Asp Tyr Ala Met Leu Leu Thr Ser Asp His Gly Asn Cys Glu
420 425 430Arg Met Lys Asp Glu Asn Gln Asn Pro Leu Thr Asn His Thr Ala Gly
435 440 445Ser Val Tyr Cys Phe Val Leu Gly Asp Gly Val Lys Ser Ile Lys Asn
450 455 460Gly Ala Leu Asn Asn Ile Ala Ser Ser Val Leu Lys Leu Met Gly Leu465 470 475 480Lys Ala Pro Ala Thr Met Asp Glu Pro Leu Phe
485 490
(2) Sequence 477 data:
(i) sequence characteristics:
(A) length: 1440bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 72...1379
(D) Other information:
(xi) Description of the sequence: sequence 477: ATAGTAAAAT CAAATAACCT TATTTTAACC AAAGGTTATT AAAATTATCC TTATTATAGA 60GAGTTTTTAA C ATG AAT TTT CAA GAA AAT TTA GCC GCT TTG GAT TTG GAG 110
Met Asn Phe Gln Glu Asn Leu Ala Ala Leu Asp Leu Glu
1 5 10TAT CTT TGG CAC CCT TGT TCG CAA ATG CAA GAG CAT CAA AAT TTC CCC 158Tyr Leu Trp His Pro Cys Ser Gln Met Gln Glu His Gln Asn Phe Pro
15 20 25ATT ATC CCC ATT AAA AAG GCT CAA GGG ATT TAC CTC TAT GAT TTT AAT 206Ile Ile Pro Ile Lys Lys Ala Gln Gly Ile Tyr Leu Tyr Asp Phe Asn30 35 40 45GAT AAC GCT TAC ATG GAT TTG ATC AGC TCA TGG TGG GTG AAT CTT TTT 254Asp Asn Ala Tyr Met Asp Leu Ile Ser Ser Trp Trp Val Asn Leu Phe
50 55 60GGG CAT AAT AAC GCC TAC ATC AGC CAG CAA CTC AAA AAT CAA ATT GAT 302Gly His Asn Asn Ala Tyr Ile Ser Gln Gln Leu Lys Asn Gln Ile Asp
65 70 75GAT TTA GAG CAT GTC CTT TTG GCT TCT TTT AGC CAT AAG CCC ATT ATC 350Asp Leu Glu His Val Leu Leu Ala Ser Phe Ser His Lys Pro Ile Ile
80 85 90ACG CTC TCT CAA AGG CTT TGC CAG CTC ACT CAT ATG GAT AAA TGC TTT 398Thr Leu Ser Gln Arg Leu Cys Gln Leu Thr His Met Asp Lys Cys Phe
95 100 105TAT GCG GAT AAC GGC TCA TCT TGT GTT GAA ATC GCT TTG AAA ATG AGC 446Tyr Ala Asp Asn Gly Ser Ser Cys Val Glu Ile Ala Leu Lys Met Ser110 115 120 125TAT CAC GCC CAT TTT TTA AAG AAT CAA ACG CGC CGC AAA AAG CTT TTT 494Tyr His Ala His Phe Leu Lys Asn Gln Thr Arg Arg Lys Lys Leu Phe
130 135 140TTA TCG CTC TCT AAT TCC TAT CAT GGC GAG ACT TTG GGA GCG TTA AGC 542Leu Ser Leu Ser Asn Ser Tyr His Gly Glu Thr Leu Gly Ala Leu Ser
145 150 155GTG GGC GAT GTG AAA CTT TAT AAA GAC ACT TAC ACC CCT TTA TTG CTC 590Val Gly Asp Val Lys Leu Tyr Lys Asp Thr Tyr Thr Pro Leu Leu Leu
160 165 170AAA AAT CTC ACC ACA CCT GTG CCT AAA AAC GAC CAT GAA ATA GAA AAT 638Lys Asn Leu Thr Thr Pro Val Pro Lys Asn Asp His Glu Ile Glu Asn
175 180 185AGT TTG AAC GCT TTA AAG CGT TTG TTA GAC AAG CAT AGT GAA GAA ATT 686Ser Leu Asn Ala Leu Lys Arg Leu Leu Asp Lys His Ser Glu Glu Ile190 195 200 205TGC GCT TTC ATT GCA GAG CCT CTT TTG CAA TGC GCA GGG AAT ATG CAT 734Cys Ala Phe Ile Ala Glu Pro Leu Leu Gln Cys Ala Gly Asn Met His
210 215 220ATT TAT AGC GCA AGA TAT TTA AAA CAA GCC GTT TTA TTG TGC AAG CAA 782Ile Tyr Ser Ala Arg Tyr Leu Lys Gln Ala Val Leu Leu Cys Lys Gln
225 230 235AAA AAC ATC CAC ATT ATT TTT GAT GAA ATC GCT ACC GGG TTT GGG CGC 830Lys Asn Ile His Ile Ile Phe Asp Glu Ile Ala Thr Gly Phe Gly Arg
240 245 250ACA GGG AGC ATG TTT GCT TAT GAA CAA TGC GAA ATT AAG CCG GAT TTT 878Thr Gly Ser Met Phe Ala Tyr Glu Gln Cys Glu Ile Lys Pro Asp Phe
255 260 265TTA TGC TTG TCT AAG GGG ATT AGT GGG GGG TAT TTG CCT TTA AGC GCA 926Leu Cys Leu Ser Lys Gly Ile Ser Gly Gly Tyr Leu Pro Leu Ser Ala270 275 280 285CTA TTA ACC CAT AAT GAA ATC TAT AAC CAA TTT TAC GCC CCC TAT GAA 974Leu Leu Thr His Asn Glu Ile Tyr Asn Gln Phe Tyr Ala Pro Tyr Glu
290 295 300GAA AAT AAA GCG TTT TTG CAT TCG CAC AGC TAC ACA GGA AAC GCT TTG 1022Glu Asn Lys Ala Phe Leu His Ser His Ser Tyr Thr Gly Asn Ala Leu
305 310 315GCA TGC GCA TGC GCG AAC GCT ACG CTG GAT ATT TTT GAA AAA GAA AAT 1070Ala Cys Ala Cys Ala Asn Ala Thr Leu Asp Ile Phe Glu Lys Glu Asn
320 325 330GTT ATT GAA AAG AAC AAG GCT TTA AGC GGG TTT ATT TTT AAT ACG CTC 1118Val Ile Glu Lys Asn Lys Ala Leu Ser Gly Phe Ile Phe Asn Thr Leu
335 340 345CAA AAC GCA TTA AAA CCC TTG ATG GAG CAA CAA GTG GTG TCT GAT TTA 1166Gln Asn Ala Leu Lys Pro Leu Met Glu Gln Gln Val Val Ser Asp Leu350 355 360 365AGG CAT TTG GGC ATG GTC TTT GCC TTT GAA GTC TTT ATT CAA ACC AAA 1214Arg His Leu Gly Met Val Phe Ala Phe Glu Val Phe Ile Gln Thr Lys
370 375 380GAG CGT TTG AGT TTG GCG GTT TTT AAA AAA ACT CTA AAA AAA GGC CTG 1262Glu Arg Leu Ser Leu Ala Val Phe Lys Lys Thr Leu Lys Lys Gly Leu
385 390 395TTA TTA CGC CCT TTA AAC AAC ACC ATT TAC CTC ATG CCC CCT TAC ATT 1310Leu Leu Arg Pro Leu Asn Asn Thr Ile Tyr Leu Met Pro Pro Tyr Ile
400 405 410ATC ACG CAT GAA GAA GTC AAA AAG GCG GTT GCG GGG CTA GTG GAA ATT 1358Ile Thr His Glu Glu Val Lys Lys Ala Val Ala Gly Leu Val Glu Ile
415 420 425CTT GAT GAG TTA AGA AAA GGC TGAAAGCGTT TTTAAAAATA AAATAGTAAA AAGC 1413Leu Asp Glu Leu Arg Lys Gly430 435TTGAATTGGA TCAAGCGATA GCTTTTT 1440
(2) Sequence 478 data:
(i) sequence characteristics:
(A) length: 436 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 478: met Asn Phe Gln Glu Asn Leu Ala Ala Leu Asp Leu Glu Tyr Leu Trp 151015 His Pro Cys Ser Gln Met Gln Glu His Gln Asn Phe Pro Ile Ile Pro
20 25 30Ile Lys Lys Ala Gln Gly Ile Tyr Leu Tyr Asp Phe Asn Asp Asn Ala
35 40 45Tyr Met Asp Leu Ile Ser Ser Trp Trp Val Asn Leu Phe Gly His Asn
50 55 60Asn Ala Tyr Ile Ser Gln Gln Leu Lys Asn Gln Ile Asp Asp Leu Glu65 70 75 80His Val Leu Leu Ala Ser Phe Ser His Lys Pro Ile Ile Thr Leu Ser
85 90 95Gln Arg Leu Cys Gln Leu Thr His Met Asp Lys Cys Phe Tyr Ala Asp
100 105 110Asn Gly Ser Ser Cys Val Glu Ile Ala Leu Lys Met Ser Tyr His Ala
115 120 125His Phe Leu Lys Asn Gln Thr Arg Arg Lys Lys Leu Phe Leu Ser Leu
130 135 140Ser Asn Ser Tyr His Gly Glu Thr Leu Gly Ala Leu Ser Val Gly Asp145 150 155 160Val Lys Leu Tyr Lys Asp Thr Tyr Thr Pro Leu Leu Leu Lys Asn Leu
165 170 175Thr Thr Pro Val Pro Lys Asn Asp His Glu Ile Glu Asn Ser Leu Asn
180 185 190Ala Leu Lys Arg Leu Leu Asp Lys His Ser Glu Glu Ile Cys Ala Phe
195 200 205Ile Ala Glu Pro Leu Leu Gln Cys Ala Gly Asn Met His Ile Tyr Ser
210 215 220Ala Arg Tyr Leu Lys Gln Ala Val Leu Leu Cys Lys Gln Lys Asn Ile225 230 235 240His Ile Ile Phe Asp Glu Ile Ala Thr Gly Phe Gly Arg Thr Gly Ser
245 250 255Met Phe Ala Tyr Glu Gln Cys Glu Ile Lys Pro Asp Phe Leu Cys Leu
260 265 270Ser Lys Gly Ile Ser Gly Gly Tyr Leu Pro Leu Ser Ala Leu Leu Thr
275 280 285His Asn Glu Ile Tyr Asn Gln Phe Tyr Ala Pro Tyr Glu Glu Asn Lys
290 295 300Ala Phe Leu His Ser His Ser Tyr Thr Gly Asn Ala Leu Ala Cys Ala305 310 315 320Cys Ala Asn Ala Thr Leu Asp Ile Phe Glu Lys Glu Asn Val Ile Glu
325 330 335Lys Asn Lys Ala Leu Ser Gly Phe Ile Phe Asn Thr Leu Gln Asn Ala
340 345 350Leu Lys Pro Leu Met Glu Gln Gln Val Val Ser Asp Leu Arg His Leu
355 360 365Gly Met Val Phe Ala Phe Glu Val Phe Ile Gln Thr Lys Glu Arg Leu
370 375 380Ser Leu Ala Val Phe Lys Lys Thr Leu Lys Lys Gly Leu Leu Leu Arg385 390 395 400Pro Leu Asn Asn Thr Ile Tyr Leu Met Pro Pro Tyr Ile Ile Thr His
405 410 415Glu Glu Val Lys Lys Ala Val Ala Gly Leu Val Glu Ile Leu Asp Glu
420 425 430Leu Arg Lys Gly
435
(2) Sequence 479 data:
(i) sequence characteristics:
(A) length: 360bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 82...294
(D) Other information:
(xi) Description of the sequence: sequence 479: AAAGCTAAAC AAGAGCAAGA GAAACGCATG GCATAAGAGC CATGCGCTTG GCAGTGAAAC 60AAAAGAAAAA AAGGAAACAA C ATG GGA AAA ATG AAA CAA GAA ACA GCG ATT 111
Met Gly Lys Met Lys Gln Glu Thr Ala Ile
1 5 10GAC TAT GAA AAA TTA GCG AAT CAT TGG AAT AAT AAT GAT GAA AAC AGC 159Asp Tyr Glu Lys Leu Ala Asn His Trp Asn Asn Asn Asp Glu Asn Ser
15 20 25GAA GCA CTA AAC GCT TTT GCA GAC GCT TAC CTT TAT AAA CAT GAG AAA 207Glu Ala Leu Asn Ala Phe Ala Asp Ala Tyr Leu Tyr Lys His Glu Lys
30 35 40AAG AGT CAA AAG ATT CGG GCA ATA GAG ATA AGT TCT CTA AAC AAA GCC 255Lys Ser Gln Lys Ile Arg Ala Ile Glu Ile Ser Ser Leu Asn Lys Ala
45 50 55TGC ATG GGA GAA TTT TAC CAC AAA AAC CCA AAA TTA TTT TAATAACGAT CG 306Cys Met Gly Glu Phe Tyr His Lys Asn Pro Lys Leu Phe
60 65 70CTCCAAGGAA CCAACGCCCC ATGACCTCAA GAAAAGAGAA TAGCTTGAAT CGGT 360
(2) Sequence 480 data:
(i) sequence characteristics:
(A) length: 71 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 480: met Gly Lys Met Lys Gln Glu Thr Ala Ile Asp Tyr Glu Lys Leu Ala 151015 Asn His Trp Asn Asn Asn Asp Glu Asn Ser Glu Ala Leu Asn Ala Phe
20 25 30Ala Asp Ala Tyr Leu Tyr Lys His Glu Lys Lys Ser Gln Lys Ile Arg
35 40 45Ala Ile Glu Ile Ser Ser Leu Asn Lys Ala Cys Met Gly Glu Phe Tyr
50 55 60His Lys Asn Pro Lys Leu Phe65 70
(2) Sequence 481 data:
(i) sequence characteristics:
(A) length: 1300bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 62...1255
(D) Other information:
(xi) Description of the sequence: sequence 481: TTGCTAACTC AAAAGGCGAA TTGCAATATT CTAACACGCC TAATATTTAT AAGGCGATTA 60A AGA CAT AGA AAC AGA GCT AGA TGC ACT AGA AAA CAG GCT AGA AAC AAT 109 Arg His Arg Asn Arg Ala Arg Cys Thr Arg Lys Gln Ala Arg Asn Asn 151015 AAG AGT TTT AGG CAT GAA AAC TAT TTT TAT AAA GTT TTG GGT AGT GCA 157Lys Ser Phe Arg His Glu Asn Tyr Phe Tyr Lys Val Leu Gly Ser Ala
20 25 30ACT TCT CAA ATA GAA AGT TTG AAA AAA AGA GAA AAT GCC CTA TTT GAT 205Thr Ser Gln Ile Glu Ser Leu Lys Lys Arg Glu Asn Ala Leu Phe Asp
35 40 45CAT TTA GAT AGT CTA AAA AGT TTA TTA GAA AAA ACA CAT TGG GAA AAA 253His Leu Asp Ser Leu Lys Ser Leu Leu Glu Lys Thr His Trp Glu Lys
50 55 60GAA AAA TTC ACG CCC CCA ATA AAT GAA AAA GAA CTT AAT AGG CAA CTT 301Glu Lys Phe Thr Pro Pro Ile Asn Glu Lys Glu Leu Asn Arg Gln Leu 65 70 75 80AAA GAA GTG AGA TGG TTC AAT AAA GAA ACT CCA ACT TCT AAA AAC ACT 349Lys Glu Val Arg Trp Phe Asn Lys Glu Thr Pro Thr Ser Lys Asn Thr
85 90 95TAT AAG AAA ATT CAA AAA TTA GCT GTT TAT AAA AGC CCT TTA ATA AAA 397Tyr Lys Lys Ile Gln Lys Leu Ala Val Tyr Lys Ser Pro Leu Ile Lys
100 105 110GAT TAT CTT TAT ACC ATT AAA AAA CTT TTT GCC ACA CAA AAA AAG ATT 445Asp Tyr Leu Tyr Thr Ile Lys Lys Leu Phe Ala Thr Gln Lys Lys Ile
115 120 125ATA GAT TTA GAA AAA AAT TAT AAA GAT TTA AGA GCC TTA AAG GAA GAA 493Ile Asp Leu Glu Lys Asn Tyr Lys Asp Leu Arg Ala Leu Lys Glu Glu
130 135 140TTT AGC AAA GAT TTA GAA ACT GAT TTA TCC CAT TCA AAA AAA CGC TTT 541Phe Ser Lys Asp Leu Glu Thr Asp Leu Ser His Ser Lys Lys Arg Phe145 150 155 160GAA CTT TAC ACT AGA CTA AAG AGC ATG AGC AAA GTT TTT ATA AGC AAA 589Glu Leu Tyr Thr Arg Leu Lys Ser Met Ser Lys Val Phe Ile Ser Lys
165 170 175AGC ATT GTT AAA AAT TTA GAA AAA ATT GCT TTA GAT TTT AAA AGC GAT 637Ser Ile Val Lys Asn Leu Glu Lys Ile Ala Leu Asp Phe Lys Ser Asp
180 185 190AGA CAT AGT ATT TCG CAA AGA GCT TTT GAA TTT TTT AAG TAT ATG AAT 685Arg His Ser Ile Ser Gln Arg Ala Phe Glu Phe Phe Lys Tyr Met Asn
195 200 205TAT CAA AAT TTA AGC TTG ACT GAT AAA GGC AAT ATG TTT TTA GTG GCT 733Tyr Gln Asn Leu Ser Leu Thr Asp Lys Gly Asn Met Phe Leu Val Ala
210 215 220AAG TTT TTT AAA GAT AGT GCT TTA CTT GTT AAT ATT GCT AGG TTT GAA 781Lys Phe Phe Lys Asp Ser Ala Leu Leu Val Asn Ile Ala Arg Phe Glu225 230 235 240ATG AAA AAG ATA GAT GAT AGT GTT AAA AAT TCT AAC CCA CAA GAC AAT 829Met Lys Lys Ile Asp Asp Ser Val Lys Asn Ser Asn Pro Gln Asp Asn
245 250 255TTA TTA GAC AAA CAA GTT TGG CTC AAT CTT TTA GAG CAT TTA AAA AGA 877Leu Leu Asp Lys Gln Val Trp Leu Asn Leu Leu Glu His Leu Lys Arg
260 265 270CTT GAA GAG GAA AAT TAT TGT TTT GCT AAG AAA CGA AAA GAA TTC TTA 925Leu Glu Glu Glu Asn Tyr Cys Phe Ala Lys Lys Arg Lys Glu Phe Leu
275 280 285GAG ACT AGA GCG ATG GAG CTA TCA AAA GAT TTA AAA TTT TTA ACA CAG 973Glu Thr Arg Ala Met Glu Leu Ser Lys Asp Leu Lys Phe Leu Thr Gln
290 295 300GCT AAT GAA AAT GAT TTG CCC ATT TAT GAA AGA GGG CAA AGG GAT AAA 1021Ala Asn Glu Asn Asp Leu Pro Ile Tyr Glu Arg Gly Gln Arg Asp Lys305 310 315 320ATC ATT AAA CGC TGT GAA AAA TCG CTT AAC TTT TTG CAG AAA GAA TTA 1069Ile Ile Lys Arg Cys Glu Lys Ser Leu Asn Phe Leu Gln Lys Glu Leu
325 330 335CAA TGC TTT AAA ACC TTA TTG AAA AGT GCA AGT ATA GCT TTA GAA AAC 1117Gln Cys Phe Lys Thr Leu Leu Lys Ser Ala Ser Ile Ala Leu Glu Asn
340 345 350TTG CAA AAT AAC CAT CAA ATC ACA GCC GTT ACA CAA GAC ACG CAA GAA 1165Leu Gln Asn Asn His Gln Ile Thr Ala Val Thr Gln Asp Thr Gln Glu
355 360 365AAC ACA AAC GCG CTC AAA AAT ACT ACT CAA GAT TTT AAC AAA ACT ACC 1213Asn Thr Asn Ala Leu Lys Asn Thr Thr Gln Asp Phe Asn Lys Thr Thr
370 375 380AAT GAA CCA ACA AAC CCT AAC AAT AAC TAT GGA ATG GAT TTT TAAAACCAT 1264Asn Glu Pro Thr Asn Pro Asn Asn Asn Tyr Gly Met Asp Phe385 390 395CCATAAAATT AAATAACTTT ACTTAGCGTA TTTTTT 1300
(2) Sequence 482 data:
(i) sequence characteristics:
(A) length: 398 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 482: arg His Arg Asn Arg Ala Arg Cys Thr Arg Lys Gln Ala Arg Asn Asn 151015 Lys Ser Phe Arg His Glu Asn Tyr Phe Tyr Lys Val Leu Gly Ser Ala
20 25 30Thr Ser Gln Ile Glu Ser Leu Lys Lys Arg Glu Asn Ala Leu Phe Asp
35 40 45His Leu Asp Ser Leu Lys Ser Leu Leu Glu Lys Thr His Trp Glu Lys
50 55 60Glu Lys Phe Thr Pro Pro Ile Asn Glu Lys Glu Leu Asn Arg Gln Leu65 70 75 80Lys Glu Val Arg Trp Phe Asn Lys GLu Thr Pro Thr Ser Lys Asn Thr
85 90 95Tyr Lys Lys Ile Gln Lys Leu Ala Val Tyr Lys Ser Pro Leu Ile Lys
100 105 110Asp Tyr Leu Tyr Thr Ile Lys Lys Leu Phe Ala Thr Gln Lys Lys Ile
115 120 125Ile Asp Leu Glu Lys Asn Tyr Lys Asp Leu Arg Ala Leu Lys Glu Glu
130 135 140Phe Ser Lys Asp Leu Glu Thr Asp Leu Ser His Ser Lys Lys Arg Phe145 150 155 160Glu Leu Tyr Thr Arg Leu Lys Ser Met Ser Lys Val Phe Ile Ser Lys
165 170 175Ser Ile Val Lys Asn Leu Glu Lys Ile Ala Leu Asp Phe Lys Ser Asp
180 185 190Arg His Ser Ile Ser Gln Arg Ala Phe Glu Phe Phe Lys Tyr Met Asn
195 200 205Tyr Gln Asn Leu Ser Leu Thr Asp Lys Gly Asn Met Phe Leu Val Ala
210 215 220Lys Phe Phe Lys Asp Ser Ala Leu Leu Val Asn Ile Ala Arg Phe Glu225 230 235 240Met Lys Lys Ile Asp Asp Ser Val Lys Asn Ser Asn Pro Gln Asp Asn
245 250 255Leu Leu Asp Lys Gln Val Trp Leu Asn Leu Leu Glu His Leu Lys Arg
260 265 270Leu Glu Glu Glu Asn Tyr Cys Phe Ala Lys Lys Arg Lys Glu Phe Leu
275 280 285Glu Thr Arg Ala Met Glu Leu Ser Lys Asp Leu Lys Phe Leu Thr Gln
290 295 300Ala Asn Glu Asn Asp Leu Pro Ile Tyr Glu Arg Gly Gln Arg Asp Lys305 310 315 320Ile Ile Lys Arg Cys Glu Lys Ser Leu Asn Phe Leu Gln Lys Glu Leu
325 330 335Gln Cys Phe Lys Thr Leu Leu Lys Ser Ala Ser Ile Ala Leu Glu Asn
340 345 350Leu Gln Asn Asn His Gln Ile Thr Ala Val Thr Gln Asp Thr Gln Glu
355 360 365Asn Thr Asn Ala Leu Lys Asn Thr Thr Gln Asp Phe Asn Lys Thr Thr
370375 380Asn Glu Pro Thr Asn Pro Asn Asn Asn Tyr Gly Met Asp Phe385 390 395
(2) Sequence 483 data:
(i) sequence characteristics:
(A) length: 630bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 105...518
(D) Other information:
(xi) Description of the sequence: sequence 483: GTTGCAACTT ATCTTGTTGT TCTTTAGTGG GATACAAGCG GAATTTAAAA CCCTTATTGA 60CTTTCATAGA AAGTATTTTA ACCTCTTTTT GTTAAAATAG GTCT ATG AAA AAA ATT 116
Met Lys Lys Ile
1GAT GAT ATG AGA CAC GGA AGA CAT TGT GTT TTT TTA ATG CAT GTG CAT 164Asp Asp Met Arg His Gly Arg His Cys Val Phe Leu Met His Val His 5 10 15 20TTT GTA TTT GTT ACT AAA TAC AGG CGT TCA GCA TTC AAT AAG GAA GTG 212Phe Val Phe Val Thr Lys Tyr Arg Arg Ser Ala Phe Asn Lys Glu Val
25 30 35ATA GAT TTT TTA GGA TCG GTG TTT GCC AAA GTG TGT AAG GAC TTT GAG 260Ile Asp Phe Leu Gly 5er Val Phe Ala Lys Val Cys Lys Asp Phe Glu
40 45 50AGC GAA TTG GTA GAA TTT GAT GGG GAG AGC GAT CAT GTG CAT TTG CTT 308Ser Glu Leu Val Glu Phe Asp Gly Glu Ser Asp His Val His Leu Leu
55 60 65ATC AAC TAC CCT CCA AAA GTG AGC GTG AGT AAG TTA GTT AAT TCT TTA 356Ile Asn Tyr Pro Pro Lys Val Ser Val Ser Lys Leu Val Asn Ser Leu
70 75 80AAA GGC GTT AGC AGT CGT TTG ACT AGA CAA CAC CAT TTC AAA AGC GTT 404Lys Gly Val Ser Ser Arg Leu Thr Arg Gln His His Phe Lys Ser Val85 90 95 100GAA GCT AGT TTG TGG GGG AAG CAT TTA TGG TCG CCT AGT TAT TTC GCT 452Glu Ala Ser Leu Trp Gly Lys His Leu Trp Ser Pro Ser Tyr Phe Ala
105 110 115GGG AGT TGT GGG GAC GCG CCT TTA GAG ATG ATT AAG CAA TAC ATA CAA 500Gly Ser Cys Gly Asp Ala Pro Leu Glu Met Ile Lys Gln Tyr Ile Gln
120 125 130GAT CAA GAA ACA CCG CAT TAAATTAGCT AACTTTGATT TTTAAGTAGA ACGCGCTA 556Asp Gln Glu Thr Pro His
135AAAAGCGAAT GGATCTAAGT GAAACAATGT TCAAATAGCC TAACGGCTAA ACGCTTACAT 616CTCCGCCCTA AAGG 630
(2) Sequence 484 data:
(i) sequence characteristics:
(A) length: 138 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 484: met Lys Lys Ile Asp Asp Met Arg His Gly Arg His Cys Val Phe Leu 151015 Met His Val His Phe Val Phe Val Thr Lys Tyr Arg Arg Ser Ala Phe
2025 30Asn Lys Glu Val Ile Asp Phe Leu Gly Ser Val Phe Ala Lys Val Cys
35 40 45Lys Asp Phe Glu Ser Glu Leu Val Glu Phe Asp Gly Glu Ser Asp His
50 55 60Val His Leu Leu Ile Asn Tyr Pro Pro Lys Val Ser Val Ser Lys Leu65 70 75 80Val Asn Ser Leu Lys Gly Val Ser Ser Arg Leu Thr Arg Gln His His
85 90 95Phe Lys Ser Val Glu Ala Ser Leu Trp Gly Lys His Leu Trp Ser Pro
100 105 110Ser Tyr Phe Ala Gly Ser Cys Gly Asp Ala Pro Leu Glu Met Ile Lys
115 120 125Gln Tyr Ile Gln Asp Gln Glu Thr Pro His
130 135
(2) Sequence 485 data:
(i) sequence characteristics:
(A) length: 1080bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 101...1000
(D) Other information:
(xi) Description of the sequence: and (2) sequence 485: TGGATTTAAA AGTGAGCGAT TTGGTGCGTG TGGCCAATGA ATATTTTAAA GACACCCAAT 60CAACCACCGT GTTTTTGAAA CCTTAAAAGA GCCTTATAAC ATG CAA TTT CAT TCA 115
Met Gln Phe His Ser
1 5TCT AGC GCG TTG ATT ACG CCT TTT AAA AAA GAT TTG AGC GTT GAT GAG 163Ser Ser Ala Leu Ile Thr Pro Phe Lys Lys Asp Leu Ser Val Asp Glu
10 15 20GCC GCT TAT GAA ACC TTG ATC AAG CGC CAA ATT TTT CAG GGC ATG GAC 211Ala Ala Tyr Glu Thr Leu Ile Lys Arg Gln Ile Phe Gln Gly Met Asp
25 30 35GCA TGC GTG CCT GTT GGC ACG ACA GGA GAA TCC GCC ACG CTC ACC CAC 259Ala Cys Val Pro Val Gly Thr Thr Gly Glu Ser Ala Thr Leu Thr His
40 45 50AAA GAG CAC ATG CGT TGC ATT GAA ATC GCC ATA GAA ACT TGC AAA AAC 307Lys Glu His Met Arg Cys Ile Glu Ile Ala Ile Glu Thr Cys Lys Asn
55 60 65ACT AAA ACG CCC TCA AAT TCG CGC ATG AAA GTG TTA GCC GGC GTG GGC 355Thr Lys Thr Pro Ser Asn Ser Arg Met Lys Val Leu Ala Gly Val Gly70 75 80 85AGT AAC GCC ACG AGC GAG TCC CTT TCT TTA GCA AAG TTC GCT CAA AAA 403Ser Asn Ala Thr Ser Glu Ser Leu Ser Leu Ala Lys Phe Ala Gln Lys
90 95 100ATC GGC GCG GAT GCG ATT TTA TGC GTA AGC CCT TAT TAT AAC CGC CCC 451Ile Gly Ala Asp Ala Ile Leu Cys Val Ser Pro Tyr Tyr Asn Arg Pro
105 110 115ACC CAA CAA GGC TTG TTT GAA CAT TAT AAA ACC ATC GCT CAA TCG GTG 499Thr Gln Gln Gly Leu Phe Glu His Tyr Lys Thr Ile Ala Gln Ser Val
120 125 130GAA ATC CCT GTC ATG CTT TAT GAT GTG CCA AGT AGA ACA GGC GTG TCT 547Glu Ile Pro Val Met Leu Tyr Asp Val Pro Ser Arg Thr Gly Val Ser
135 140145ATT GAA GTT CCA ACC GCC CTC AAA CTC TTT AGA GAA GTC CCT AAC ATT 595Ile Glu Val Pro Thr Ala Leu Lys Leu Phe Arg Glu Val Pro Asn Ile150 155 160 165AAA GCC ATT AAA GAA GCG TCT GGC TCT TTG AAA AGG GTA ACA GAA TTG 643Lys Ala Ile Lys Glu Ala Ser Gly Ser Leu Lys Arg Val Thr Glu Leu
170 175 180CAT TAT TAT GAA AAA GAT TTT AAA ATT TTT AGT GGG GAA GAT TCG CTC 691His Tyr Tyr Glu Lys Asp Phe Lys Ile Phe Ser Gly Glu Asp Ser Leu
185 190 195AAC CAC TCC ATC ATG TTT TCA GGG GGG TGC GGC GTG ATT TCA GTG ACC 739Asn His Ser Ile Met Phe Ser Gly Gly Cys Gly Val Ile Ser Val Thr
200 205 210GGT AAT TTA ATG CCC AAT CTG ATT TCA CAA ATG GTC AAT TGC GCG CTC 787Gly Asn Leu Met Pro Asn Leu Ile Ser Gln Met Val Asn Cys Ala Leu
215 220 225AAA CAA AAA TAC CAA CAA GCC CTA GAA ATC CAA AAT AAG CTT TGT TGT 835Lys Gln Lys Tyr Gln Gln Ala Leu Glu Ile Gln Asn Lys Leu Phe Cys230 235 240 245TTG CAC CAA GCC CTT TTT GTA GAA ACA AAT CCC ATC CCT ATT AAA ATG 883Leu His Gln Ala Leu Phe Val Glu Thr Asn Pro Ile Pro Ile Lys Met
250 255 260GCT ATG CAT TTA GCC GGC TTG ATT GAA AAC CCA AGC TAC AGA CTG CCT 931Ala Met His Leu Ala Gly Leu Ile Glu Asn Pro Ser Tyr Arg Leu Pro
265 270 275TTA GTG GCC CCA AGC AAA GAA ACG ATT CAA CTT TTA GAA AAA ACT TTA 979Leu Val Ala Pro Ser Lys Glu Thr Ile Gln Leu Leu Glu Lys Thr Leu
280 285 290CAA CAA TAT GAG GTA ATT GCA TGAATGGTTC CAATCACATG AAAAATAAAA CCCT 1034Gln Gln Tyr Glu Val Ile Ala
295 300AGTGATCAGC GGCGCGACTA GAGGGATTGG CAAGGCGATA TTGTAC 1080
(2) Sequence 486 data:
(i) sequence characteristics:
(A) length: 300 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 486: met Gln Phe His Ser Ser Ser Ala Leu Ile Thr Pro Phe Lys Lys Asp 151015 Leu Ser Val Asp Glu Ala Ala Tyr Glu Thr Leu Ile Lys Arg Gln Ile
20 25 30Phe Gln Gly Met Asp Ala Cys Val Pro Val Gly Thr Thr Gly Glu Ser
35 40 45Ala Thr Leu Thr His Lys Glu His Met Arg Cys Ile Glu Ile Ala Ile
50 55 60Glu Thr Cys Lys Asn Thr Lys Thr Pro Ser Asn Ser Arg Met Lys Val65 70 75 80Leu Ala Gly Val Gly Ser Asn Ala Thr Ser Glu Ser Leu Ser Leu Ala
85 90 95Lys Phe Ala Gln Lys Ile Gly Ala Asp Ala Ile Leu Cys Val Ser Pro
100 105 110Tyr Tyr Asn Arg Pro Thr Gln Gln Gly Leu Phe Glu His Tyr Lys Thr
115 120 125Ile Ala Gln Ser Val Glu Ile Pro Val Met Leu Tyr Asp Mal Pro Ser
130 135 140Arg Thr Gly Val Ser Ile Glu Val Pro Thr Ala Leu Lys Leu Phe Arg145 150 155 160Glu Val Pro Asn Ile Lys Ala Ile Lys Glu Ala Ser Gly Ser Leu Lys
165 170 175Arg Val Thr Glu Leu His Tyr Tyr Glu Lys Asp Phe Lys Ile Phe Ser
180 185 190Gly Glu Asp Ser Leu Asn His Ser Ile Met Phe Ser Gly Gly Cys Gly
195 200 205Val Ile Ser Val Thr Gly Asn Leu Met Pro Asn Leu Ile Ser Gln Met
210 215 220Val Asn Cys Ala Leu Lys Gln Lys Tyr Gln Gln Ala Leu Glu Ile Gln225 230 235 240Asn Lys Leu Phe Cys Leu His Gln Ala Leu Phe Val Glu Thr Asn Pro
245 250 255Ile Pro Ile Lys Met Ala Met His Leu Ala Gly Leu Ile Glu Asn Pro
260 265 270Ser Tyr Arg Leu Pro Leu Val Ala Pro Ser Lys Glu Thr Ile Gln Leu
275 280 285Leu Glu Lys Thr Leu Gln Gln Tyr Glu Val Ile Ala
290 295 300
(2) Sequence 487 data:
(i) sequence characteristics:
(A) length: 1709bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword:coding sequence
(B) Position: 68...1624
(D) Other information:
(xi) Description of the sequence: sequence 487: AAAAAACCTT AAAACGCTTA AAAAACTATC GCTTGATCAA GCTCTTTTAC TATTTAATCT 60TTAAAAA ATG CTT TTG ATC GTT TTT TTT AAA TTT TAT TTT CAA TAT TCA 109
Met Leu Leu Ile Val Phe Phe Lys Phe Tyr Phe Gln Tyr Ser
1 5 10ATT AAA AAA AAA TCA TTT TAT TTT ATT TTT GTT ATA ATT CAA GCT ATT 157Ile Lys Lys Lys Ser Phe Tyr Phe Ile Phe Val Ile Ile Gln Ala Ile15 20 25 30TTT ATT TTC AAT CTA AGG AGG TGT CGC ATG GAC AAT CAA AAG ATA ACG 205Phe Ile Phe Asn Leu Arg Arg Cys Arg Met Asp Asn Gln Lys Ile Thr
35 40 45CAT CAA AAT ATC ACG CAA AAA CAA GGC GAG CTT AAA AGA GAC ATG AAA 253His Gln Asn Ile Thr Gln Lys Gln Gly Glu Leu Lys Arg Asp Met Lys
50 55 60ATG CGC CAT CTC TTA ATG ATT GCA TTT GGA GGA GCG ATC GGC ACA GGG 301Met Arg His Leu Leu Met Ile Ala Phe Gly Gly Ala Ile Gly Thr Gly
65 70 75CTT TTT GTA GGC ACT GGG GGT AAT ATT GCG AGC GCT GGC CCT TTA GGG 349Leu Phe Val Gly Thr Gly Gly Asn Ile Ala Ser Ala Gly Pro Leu Gly
80 85 90ACC TTG ATC GCT TAT TGT TTT GGA GGG CTT GTG GTC TAT TGT ATC ATG 397Thr Leu Ile Ala Tyr Cys Phe Gly Gly Leu Val Val Tyr Cys Ile Met95 100 105 110CTC TCT TTA GGC GAA TTG GCT AGC GTT TAT CCC ACT ACA GGA AGT TTT 445Leu Ser Leu Gly Glu Leu Ala Ser Val Tyr Pro Thr Thr Gly Ser Phe
115 120125GGG GAT TAT GCG GCT AAA TTC ATA GGC CCT GGC ACG GGC TAT ATG GTT 493Gly Asp Tyr Ala Ala Lys Phe Ile Gly Pro Gly Thr Gly Tyr Met Val
130 135 140TTT TGG ATG TAT TGG CTT GGC TGG GTG ATC ACG GTG GCG TTA GAA TAC 541Phe Trp Met Tyr Trp Leu Gly Trp Val Ile Thr Val Ala Leu Glu Tyr
145 150 155ATC GCT ATA GGC ATG CTC ATG CAA CGC TGG TTT GCG GAT ATT CCC ATC 589Ile Ala Ile Gly Met Leu Met Gln Arg Trp Phe Ala Asp Ile Pro Ile
160 165 170CAT TAT TGG GTT ATT TTA TGC ATT GCG TTA GTT TTT TTA TTG AAC TTT 637His Tyr Trp Val Ile Leu Cys Ile Ala Leu Val Phe Leu Leu Asn Phe175 180 185 190TTT TCG GTT AAA ATT TTT GCC GAG GGC GAG TTT TTC TTT AGC CTG ATT 685Phe Ser Val Lys Ile Phe Ala Glu Gly Glu Phe Phe Phe Ser Leu Ile
195 200 205AAA GTT TTA GCG GTG ATC GCT TTT ATA GGC ATT GGC GCG ATT GGG ATT 733Lys Val Leu Ala Val Ile Ala Phe Ile Gly Ile Gly Ala Ile Gly Ile
210 215 220ATT TAT CAA ATC TAT TCG CAT GGG TTT GGT TCT ATT TTT GAT AAT TTC 781Ile Tyr Gln Ile Tyr Ser His Gly Phe Gly Ser Ile Phe Asp Asn Phe
225 230 235CAT TTT GGC GAT AAG GGG TTT TTC CCT AAT GGG AGC GCA GCG GTT TTT 829His Phe Gly Asp Lys Gly Phe Phe Pro Asn Gly Ser Ala Ala Val Phe
240 245 250AGC GCG ATG CTC GCT GTT ATT TTT GCT TTC ACT GGC ACA GAG GTG ATT 877Ser Ala Met Leu Ala Val Ile Phe Ala Phe Thr Gly Thr Glu Val Ile255 260 265 270GGG GTG GCT GTG GGA GAG ACT AAA AAC GCT AGC GAA GTG ATG CCC AAA 925Gly Val Ala Val Gly Glu Thr Lys Asn Ala Ser Glu Val Met Pro Lys
275 280 285GCG ATT AAA GCG ACC TTG TGG CGG ATT GTC TTT TTC TTT TTA GGC TCT 973Ala Ile Lys Ala Thr Leu Trp Arg Ile Val Phe Phe Phe Leu Gly Ser
290 295 300GTG TTT GTC ATT TCT GTT TTT TTA CCC ATG AAT GAT TCT TCT ATC ACG 1021Val Phe Val Ile Ser Val Phe Leu Pro Met Asn Asp Ser Ser Ile Thr
305 310 315CAA AGC CCT TTT GTG AGC GTT TTA GAA CGC ATT AAT TTG CCC TTT ATT 1069Gln Ser Pro Phe Val Ser Val Leu Glu Arg Ile Asn Leu Pro Phe Ile
320 325 330GGC ATG GGT ATC CCT TAT GTG GCT GAT ATA ATG AAC GCT GTT ATC ATT 1117Gly Met Gly Ile Pro Tyr Val Ala Asp Ile Met Asn Ala Val Ile Ile335 340 345 350ACG GCG ATG TTT TCT ACC GCT AAT TCA GGG CTT TAT GGA GCG AGC CGC 1165Thr Ala Met Phe Ser Thr Ala Asn Ser Gly Leu Tyr Gly Ala Ser Arg
355 360 365ATG ATT TAT GGG CTG TCC AAA CAA AAG ATG TTT TTT AAG GTT TTT TCC 1213Met Ile Tyr Gly Leu Ser Lys Gln Lys Met Phe Phe Lys Val Phe Ser
370 375 380CAA CTC AAC CGA CAA GGC ACG CCC ACT TAT GCG ATG TTT TTT TCC CTT 1261Gln Leu Asn Arg Gln Gly Thr Pro Thr Tyr Ala Met Phe Phe Ser Leu
385 390 395TCT TTT TCT CTC ATA GGG CTT TTA GTC CAA ATT TAT GCC AAA GAA AAT 1309Ser Phe Ser Leu Ile Gly Leu Leu Val Gln Ile Tyr Ala Lys Glu Asn
400 405 410GTC GTG GAA GCT TTG ATT AAT GTG ATC AGT TTC ACG GTG ATT ATT GTG 1357Val Val Glu Ala Leu Ile Asn Val Ile Ser Phe Thr Val Ile Ile Val415 420425 430TGG GTT AGC GTG TCT GTT TCG CAA TAT TCT TTC CGC AAG CAA TAC TTA 1405Trp Val Ser Val Ser Val Ser Gln Tyr Ser Phe Arg Lys Gln Tyr Leu
435 440 445AAA GCC GGG CAT TCT TTA GAG GAT TTG CCT TAT AAA GCC CCC TTT CTA 1453Lys Ala Gly His Ser Leu Glu Asp Leu Pro Tyr Lys Ala Pro Phe Leu
450 455 460CCC TTT TTG CAA CTC ATA GGG ATC ACT GGG TGT GCC ATC GGC GTG ATT 1501Pro Phe Leu Gln Leu Ile Gly Ile Thr Gly Cys Ala Ile Gly Val Ile
465 470 475GGT TCG GCT ATG GAT AAG GAT CAA CGC ATT GGG ATG ATT TTA ACG ATT 1549Gly Ser Ala Met Asp Lys Asp Gln Arg Ile Gly Met Ile Leu Thr Ile
480 485 490GTT TTC GCT GTT ATT TGT TAC ATT GGA TAC TAT TTT ACA CAA AAA GCT 1597Val Phe Ala Val Ile Cys Tyr Ile Gly Tyr Tyr Phe Thr Gln Lys Ala495 500 505 510AAT GAA AAT AAC AAA AAA GAT TTG ATA TAATCTTTTC TTAATTTTGA AGTTTAG 1651Asn Glu Asn Asn Lys Lys Asp Leu Ile
515CAAATTTTAA GGAAGTAACC ATGATGAAAA AAACCCTTTT TATCTCTTTG GCTTTAGC 1709
(2) Sequence 488 data:
(i) sequence characteristics:
(A) length: 519 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 488: met Leu Leu Ile Val Phe Phe Lys Phe Tyr Phe Gln Tyr Ser Ile Lys 151015Lys Lys Ser Phe Tyr Phe Ile Phe Val Ile Ile Gln Ala Ile Phe Ile
20 25 30Phe Asn Leu Arg Arg Cys Arg Met Asp Asn Gln Lys Ile Thr His Gln
35 40 45Asn Ile Thr Gln Lys Gln Gly GLu Leu Lys Arg Asp Met Lys Met Arg
50 55 60His Leu Leu Met Ile Ala Phe Gly Gly Ala Ile Gly Thr Gly Leu Phe65 70 75 80Val Gly Thr Gly Gly Asn Ile Ala Ser Ala Gly Pro Leu Gly Thr Leu
85 90 95Ile Ala Tyr Cys Phe Gly Gly Leu Val Val Tyr Cys Ile Met Leu Ser
100 105 110Leu Gly Glu Leu Ala Ser Val Tyr Pro Thr Thr Gly Ser Phe Gly Asp
115 120 125Tyr Ala Ala Lys Phe Ile Gly Pro Gly Thr Gly Tyr Met Val Phe Trp
130 135 140Met Tyr Trp Leu Gly Trp Val Ile Thr Val Ala Leu Glu Tyr Ile Ala145 150 155 160Ile Gly Met Leu Met Gln Arg Trp Phe Ala Asp Ile Pro Ile His Tyr
165 170 175Trp Val Ile Leu Cys Ile Ala Leu Val Phe Leu Leu Asn Phe Phe Ser
180 185 190Val Lys Ile Phe Ala Glu Gly Glu Phe Phe Phe Ser Leu Ile Lys Val
195 200 205Leu Ala Val Ile Ala Phe Ile Gly Ile Gly Ala Ile Gly Ile Ile Tyr
210 215 220Gln Ile Tyr Ser His Gly Phe Gly Ser Ile Phe Asp Asn Phe His Phe225 230 235 240Gly Asp Lys Gly Phe Phe Pro Asn Gly Ser Ala Ala Val Phe Ser Ala
245 250 255Met Leu Ala Val Ile Phe Ala Phe Thr Gly Thr Glu Val Ile Gly Val
260 265 270Ala Val Gly Glu Thr Lys Asn Ala Ser Glu Val Met Pro Lys Ala Ile
275 280 285Lys Ala Thr Leu Trp Arg Ile Val Phe Phe Phe Leu Gly Ser Val Phe
290 295 300Val Ile Ser Val Phe Leu Pro Met Asn Asp Ser Ser Ile Thr Gln Ser305 310 315 320Pro Phe Val Ser Val Leu Glu Arg Ile Asn Leu Pro Phe Ile Gly Met
325 330 335Gly Ile Pro Tyr Val Ala Asp Ile Met Asn Ala Val Ile Ile Thr Ala
340 345 350Met Phe Ser Thr Ala Asn Ser Gly Leu Tyr Gly Ala Ser Arg Met Ile
355 360 365Tyr Gly Leu Ser Lys Gln Lys Met Phe Phe Lys Val Phe Ser Gln Leu
370 375 380Asn Arg Gln Gly Thr Pro Thr Tyr Ala Met Phe Phe Ser Leu Ser Phe385 390 395 400Ser Leu Ile Gly Leu Leu Val Gln Ile Tyr Ala Lys Glu Asn Val Val
405 410 415Glu Ala Leu Ile Asn Val Ile Ser Phe Thr Val Ile Ile Val Trp Val
420 425 430Ser Val Ser Val Ser Gln Tyr Ser Phe Arg Lys Gln Tyr Leu Lys Ala
435 440 445Gly His Ser Leu Glu Asp Leu Pro Tyr Lys Ala Pro Phe Leu Pro Phe
450455 460Leu Gln Leu Ile Gly Ile Thr Gly Cys Ala Ile Gly Val Ile Gly Ser465 470 475 480Ala Met Asp Lys Asp Gln Arg Ile Gly Met Ile Leu Thr Ile Val Phe
485 490 495Ala Val Ile Cys Tyr Ile Gly Tyr Tyr Phe Thr Gln Lys Ala Asn Glu
500 505 510Asn Asn Lys Lys Asp Leu Ile
515
(2) Sequence 489 data:
(i) sequence characteristics:
(A) length: 1529bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 230...1390
(D) Other information:
(xi) Description of the sequence: sequence 489: TTAAGCTTGA ATGCGGGCAA TATCCAAATC CAGAGCATGC CCAAAGTTAA AGAGCGAGTG 60AGTGTCCCCT CTAAAGACGA TACGGATCTA TTCTTACCAC GATTCTATTA AGGACTCTAT 120TAAGGCGGTG GTGAATATCT CCACTGAAAA GAAGATTAAA AACAATTTTA TAGGTGGCGG 180TGTGTTTAAT GACCCCTTTT TCCAACAATT TTTTGGGGAT TTGGGTGGC ATG ATT CCT 238
Met Ile Pro
1AAA GAA AGA ATG GAA AGG GCT TTA GGC AGC GGC GTA ATC ATT TCT AAA 286Lys Glu Arg Met Glu Arg Ala Leu Gly Ser Gly Val Ile Ile Ser Lys
5 10 15GAC GGC TAT ATT GTA ACT AAT AAC CAT GTG ATT GAT GGC GCG GAT AAG 334Asp Gly Tyr Ile Val Thr Asn Asn His Val Ile Asp Gly Ala Asp Lys20 25 30 35ATT AAA GTT ACC ATT CCA GGG AGC AAT AAA GAA TAT TCC GCC ACT CTA 382Ile Lys Val Thr Ile Pro Gly Ser Asn Lys Glu Tyr Ser Ala Thr Leu
40 45 50GTA GGC ACC GAT TCT GAA AGC GAT TTA GCG GTG ATT CGC ATC ACT AAA 430Val Gly Thr Asp Ser Glu Ser Asp Leu Ala Val Ile Arg Ile Thr Lys
55 60 65GAC AAT CTG CCC ACG ATC AAA TTC TCT GAT TCT AAT GAT ATT TCA GTG 478Asp Asn Leu Pro Thr Ile Lys Phe Ser Asp Ser Asn Asp Ile Ser Val
70 75 80GGC GAT TTG GTT TTT GCG ATT GGT AAC CCT TTT GGC GTG GGC GAA AGC 526Gly Asp Leu Val Phe Ala Ile Gly Asn Pro Phe Gly Val Gly Glu Ser
85 90 95GTT ACG CAA GGC ATT GTT TCA GCG CTC AAT AAA AGC GGG ATT GGG ATC 574Val Thr Gln Gly Ile Val Ser Ala Leu Asn Lys Ser Gly Ile Gly Ile100 105 110 115AAC AGC TAT GAG AAT TTC ATT CAA ACA GAC GCT TCC ATC AAT CCT GGA 622Asn Ser Tyr Glu Asn Phe Ile Gln Thr Asp Ala Ser Ile Asn Pro Gly
120 125 130AAT TCC GGC GGC GCT TTA ATT GAT AGC CGT GGA GGG TTA GTG GGG ATT 670Asn Ser Gly Gly Ala Leu Ile Asp Ser Arg Gly Gly Leu Val Gly Ile
135 140 145AAT ACC GCT ATT ATC TCT AAA ACT GGG GGC AAC CAC GGC ATT GGC TTT 718Asn Thr Ala Ile Ile Ser Lys Thr Gly Gly Asn His Gly Ile Gly Phe
150 155 160GCC ATC CCT TCT AAC ATG GTT AAA GAT ACT GTA ACC CAA CTC ATC AAA 766Ala Ile Pro Ser Asn Met Val Lys Asp Thr Val Thr GlnLeu Ile Lys
165 170 175ACC GGT AAG ATT GAA AGA GGT TAC TTG GGC GTG GGC TTG CAA GAT TTG 814Thr Gly Lys Ile Glu Arg Gly Tyr Leu Gly Val Gly Leu Gln Asp Leu180 185 190 195AGT GGC GAT TTG CAA AAT TCT TAT GAC AAC AAA GAA GGG GCG GTA GTC 862Ser Gly Asp Leu Gln Asn Ser Tyr Asp Asn Lys Glu Gly Ala Val Val
200 205 210ATT AGC GTA GAA AAA GAC TCT CCG GCT AAA AAA GCA GGG ATT TTG GTG 910Ile Ser Val Glu Lys Asp Ser Pro Ala Lys Lys Ala Gly Ile Leu Val
215 220 225TGG GAT TTG ATC ACC GAA GTC AAT GGG AAA AAG GTT AAA AAC ACG AAT 958Trp Asp Leu Ile Thr Glu Val Asn Gly Lys Lys Val Lys Asn Thr Asn
230 235 240GAG TTA AGA AAT CTA ATC GGC TCC ATG CTA CCC AAT CAA AGA GTA ACC 1006Glu Leu Arg Asn Leu Ile Gly Ser Met Leu Pro Asn Gln Arg Val Thr
245 250 255TTA AAA GTC ATT AGA GAC AAA AAA GAA CGC GCT TTC ACC CTC ACT CTA 1054Leu Lys Val Ile Arg Asp Lys Lys Glu Arg Ala Phe Thr Leu Thr Leu260 265 270 275GCT GAA AGG AAA AAC CCT AAC AAA AAA GAA ACC ATT TCT GCT CAA AAC 1102Ala Glu Arg Lys Asn Pro Asn Lys Lys Glu Thr Ile Ser Ala Gln Asn
280 285 290GGC GCG CAA GGC CAA TTG AAC GGG CTT CAA GTA GAA GAT TTA ACT CAA 1150Gly Ala Gln Gly Gln Leu Asn Gly Leu Gln Val Glu Asp Leu Thr Gln
295 300 305GAA ACC AAA AGG TCT ATG CGT TTG AGC GAT GAT GTT CAA GGG GTT TTA 1198Glu Thr Lys Arg Ser Met Arg Leu Ser Asp Asp Val Gln Gly Val Leu
310 315320GTC TCT CAA GTG AAT GAA AAT TCC CCA GCA GAG CAA GCC GGA TTT AGG 1246Val Ser Gln Val Asn Glu Asn Ser Pro Ala Glu Gln Ala Gly Phe Arg
325 330 335CAA GGT AAC ATT ATC ACA AAA ATT GAA GAG GTT GAA GTT AAA AGC GTT 1294Gln Gly Asn Ile Ile Thr Lys Ile Glu Glu Val Glu Val Lys Ser Val340 345 350 355GCG GAT TTT AAC CAT GCT TTA GAA AAG TAT AAA GGC AAA CCC AAA CGA 1342Ala Asp Phe Asn His Ala Leu Glu Lys Tyr Lys Gly Lys Pro Lys Arg
360 365 370TTC TTA GTT TTA GAC TTG AAT CAA GGT TAT AGG ATC ATT TTG GTG AAA T 1391Phe Leu Val Leu Asp Leu Asn Gln Gly Tyr Arg Ile Ile Leu Val Lys
375 380 385GATAGGGGTG GGTCGTTAGT CGCATGTCTT TGATTAGAGT GAATGGGGAA GCTTTTAAAC 1451TCTCTTTAGA AAGTTTAGAA GAAGACCCTT TTGAAACTAA AGAAACGCTA GAAACGCTTA 1511TCAAACAAAC GAGCGTTG 1529
(2) Sequence 490 data:
(i) sequence characteristics:
(A) length: 387 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 490: met Ile Pro Lys Glu Arg Met Glu Arg Ala Leu Gly Ser Gly Val Ile 151015 Ile Ser Lys Asp Gly Tyr Ile Val Thr Asn Asn His Val Ile Asp Gly
20 25 30Ala Asp Lys Ile Lys Val Thr Ile Pro Gly Ser Asn Lys Glu Tyr Ser
35 40 45Ala Thr Leu Val Gly Thr Asp Ser Glu Ser Asp Leu Ala Val Ile Arg
50 55 60Ile Thr Lys Asp Asn Leu Pro Thr Ile Lys Phe Ser Asp Ser Asn Asp65 70 75 80Ile Ser Val Gly Asp Leu Val Phe Ala Ile Gly Asn Pro Phe Gly Val
85 90 95Gly Glu Ser Val Thr Gln Gly Ile Val Ser Ala Leu Asn Lys Ser Gly
100 105 110Ile Gly Ile Asn Ser Tyr Glu Asn Phe Ile Gln Thr Asp Ala Ser Ile
115 120 125Asn Pro Gly Asn Ser Gly Gly Ala Leu Ile Asp Ser Arg Gly Gly Leu
130 135 140Val Gly Ile Asn Thr Ala Ile Ile Ser Lys Thr Gly Gly Asn His Gly145 150 155 160Ile Gly Phe Ala Ile Pro Ser Asn Met Val Lys Asp Thr Val Thr Gln
165 170 175Leu Ile Lys Thr Gly Lys Tle Glu Arg Gly Tyr Leu Gly Val Gly Leu
180 185 190Gln Asp Leu Ser Gly Asp Leu Gln Asn Ser Tyr Asp Asn Lys Glu Gly
195 200 205Ala Val Val Ile Ser Val Glu Lys Asp Ser Pro Ala Lys Lys Ala Gly
210 215 220Ile Leu Val Trp Asp Leu Ile Thr Glu Val Asn Gly Lys Lys Val Lys225 230 235 240Asn Thr Asn Glu Leu Arg Asn Leu Ile Gly Ser Met Leu Pro Asn Gln
245 250 255Arg Val Thr Leu Lys Val Ile Arg Asp Lys Lys Glu Arg Ala Phe Thr
260 265 270Leu Thr Leu Ala Glu Arg Lys Asn Pro Asn Lys Lys Glu Thr Ile Ser
275 280 285Ala Gln Asn Gly Ala Gln Gly Gln Leu Asn Gly Leu Gln Val Glu Asp
290 295 300Leu Thr Gln Glu Thr Lys Arg Ser Met Arg Leu Ser Asp Asp Val Gln305 310 315 320Gly Val Leu Val Ser Gln Val Asn Glu Asn Ser Pro Ala Glu Gln Ala
325 330 335Gly Phe Arg Gln Gly Asn Ile Ile Thr Lys Ile Glu Glu Val Glu Val
340 345 350Lys Ser Val Ala Asp Phe Asn His Ala Leu Glu Lys Tyr Lys Gly Lys
355 360 365Pro Lys Arg Phe Leu Val Leu Asp Leu Asn Gln Gly Tyr Arg Ile Ile
370 375 380Leu Val Lys385
(2) Sequence 491 data:
(i) sequence characteristics:
(A) length: 990bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 39...902
(D) Other information:
(xi) Description of the sequence: sequence 491: ATGATAGTAT TCTAATAAAA CTATTTTAAA GGTGATCC ATG AGT AAG AGT TTA TAC 56
Met Ser Lys Ser Leu Tyr
1 5CAA ACT TTA AAT GTG AGC GAA AAC GCC AGC CAA GAT GAA ATC AAA AAA 104Gln Thr Leu Asn Val Ser Glu Asn Ala Ser Gln Asp Glu Ile Lys Lys
10 15 20TCC TAC CGC CGT TTA GCC CGA CAA TAC CAC CCG GAT TTG AAT AAA ACC 152Ser Tyr Arg Arg Leu Ala Arg Gln Tyr His Pro Asp Leu Asn Lys Thr
25 30 35AAA GAA GCC GAA GAG AAA TTC AAA GAA ATC AAC GCC GCT TAT GAA ATT 200Lys Glu Ala Glu Glu Lys Phe Lys Glu Ile Asn Ala Ala Tyr Glu Ile
40 45 50TTG AGC GAT GAA GAA AAA CGC CGC CAA TAC GAT CAG TTT GGC GAT AAC 248Leu Ser Asp Glu Glu Lys Arg Arg Gln Tyr Asp Gln Phe Gly Asp Asn55 60 65 70ATG TTT GGC GGG CAG AAT TTC AGC GAT TTT GCC AGA AGC CGT GGT CCT 296Met Phe Gly Gly Gln Asn Phe Ser Asp Phe Ala Arg Ser Arg Gly Pro
75 80 85AGT GAA GAT TTA GAC GAT ATT TTA AGC TCT ATT TTT GGG AAA GGA GGC 344Ser Glu Asp Leu Asp Asp Ile Leu Ser Ser Ile Phe Gly Lys Gly Gly
90 95 100TTT TCG CAA AGA TTT TCT CAA AAC TCG CAA GGC TTT TCT GGC TTT AAT 392Phe Ser Gln Arg Phe Ser Gln Asn Ser Gln Gly Phe Ser Gly Phe Asn
105 110 115TTT TCC AAT TTC GCC CCT GAA AAT TTA GAC ATA ACC GCC GCT TTA AAT 440Phe Ser Asn Phe Ala Pro Glu Asn Leu Asp Ile Thr Ala Ala Leu Asn
120 125 130GTC TCT GTT TTA GAC ACC CTT TTA GGC AAT AAA AAA CAA GTG AGC ATC 488Val Ser Val Leu Asp Thr Leu Leu Gly Asn Lys Lys Gln Val Ser Ile135 140 145 150AAT AAT GAG ACT TTT AGC CTT AAA ATC CCT ATT GGC GTG GAA GAG GGC 536Asn Asn Glu Thr Phe Ser Leu Lys Ile Pro Ile Gly Val Glu Glu Gly
155 160 165GAA AAG ATT AGG GTT CGC AAC AAG GGG AAA ACG GGG CGA ACG ACT AGG 584Glu Lys Ile Arg Val Arg Asn Lys Gly Lys Thr Gly Arg Thr Thr Arg
170 175 180GGC GAT TTG CTC TTA GAG ATC CAT ATT GAA GAA GAT GAA ATG TAT AGG 632Gly Asp Leu Leu Leu Glu Ile His Ile Glu Glu Asp Glu Met Tyr Arg
185 190 195CGC GAG AAA GAT GAT ATT ACC CAA ATC TTT GAT TTA CCC TTA AAA ACG 680Arg Glu Lys Asp Asp Ile Thr Gln Ile Phe Asp Leu Pro Leu Lys Thr
200 205 210GCT CTT TTT GGA GGG AAA ATT GAA ATC GCT ACT TGG CAT AAA ACC TTA 728Ala Leu Phe Gly Gly Lys Ile Glu Ile Ala Thr Trp His Lys Thr Leu215 220 225 230ACC CTA ACC ATT CCC CCT AAC ACC AAA GCG ATG CAA AAA TTC CGC ATT 776Thr Leu Thr Ile Pro Pro Asn Thr Lys Ala Met Gln Lys Phe Arg Ile
235 240 245AAA GAA AAA GGG ATC AAA AAC AGA AAA ACT TCG CAT GTG GGG GAT TTG 824Lys Glu Lys Gly Ile Lys Asn Arg Lys Thr Ser His Val Gly Asp Leu
250 255 260TAT TTG CAG GCT CGT TTG ATT TTG CCT AAA ACT GAA ACG CTT TCT AAT 872Tyr Leu Gln Ala Arg Leu Ile Leu Pro Lys Thr Glu Thr Leu Ser Asn
265 270 275GAG TTG AAA GCG TTA TTA GAA AAA GAA TTG TAAGGAGGAA TCGTGTGCGA TTA 925Glu Leu Lys Ala Leu Leu Glu Lys Glu Leu
280 285TGATGAACCG CTTTATTTAA TCAGCGTCGT GGCTAAAATC TTAGGCGTGC ACCCTCAAAC 985CTTGC990
(2) Data for sequence 492:
(i) sequence characteristics:
(A) length: 288 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 492: met Ser Lys Ser Leu Tyr Gln Thr Leu Asn Val Ser Glu Asn Ala Ser 151015 Gln Asp Glu Ile Lys Lys Ser Tyr Arg Arg Leu Ala Arg Gln Tyr His
20 25 30Pro Asp Leu Asn Lys Thr Lys Glu Ala Glu Glu Lys Phe Lys Glu Ile
35 40 45Asn Ala Ala Tyr Glu Ile Leu Ser Asp Glu Glu Lys Arg Arg Gln Tyr
50 55 60Asp Gln Phe Gly Asp Asn Met Phe Gly Gly Gln Asn Phe Ser Asp Phe65 70 75 80Ala Arg Ser Arg Gly Pro Ser Glu Asp Leu Asp Asp Ile Leu Ser Ser
85 90 95Ile Phe Gly Lys Gly Gly Phe Ser Gln Arg Phe Ser Gln Asn Ser Gln
100 105 110Gly Phe Ser Gly Phe Asn Phe Ser Asn Phe Ala Pro Glu Asn Leu Asp
115 120 125Ile Thr Ala Ala Leu Asn Val Ser Val Leu Asp Thr Leu Leu Gly Asn
130 135 140Lys Lys Gln Val Ser Ile Asn Asn Glu Thr Phe Ser Leu Lys Ile Pro145 150 155 160Ile Gly ValGlu Glu Gly Glu Lys Ile Arg Val Arg Asn Lys Gly Lys
165 170 175Thr Gly Arg Thr Thr Arg Gly Asp Leu Leu Leu Glu Ile His Ile Glu
180 185 190Glu Asp Glu Met Tyr Arg Arg Glu Lys Asp Asp Ile Thr Gln Ile Phe
195 200 205Asp Leu Pro Leu Lys Thr Ala Leu Phe Gly Gly Lys Ile Glu Ile Ala
210 215 220Thr Trp His Lys Thr Leu Thr Leu Thr Ile Pro Pro Asn Thr Lys Ala225 230 235 240Met Gln Lys Phe Arg Ile Lys Glu Lys Gly Ile Lys Asn Arg Lys Thr
245 250 255Ser His Val Gly Asp Leu Tyr Leu Gln Ala Arg Leu Ile Leu Pro Lys
260 265 270Thr Glu Thr Leu Ser Asn Glu Leu Lys Ala Leu Leu Glu Lys Glu Leu
275 280 285
(2) Sequence 493 data:
(i) sequence characteristics:
(A) length: 1350bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 113...1285
(D) Other information:
(xi) Description of the sequence: sequence 493: ACCTGAATAA AGAGTTGCAA GACGCTCTGC ACAAACACTC TAAAAATACC AAAACCCCAA 60CGAAAAATTT AAACACCCCT ACGAATTTTT ACGAATTGAT TTTATTTAAA AA ATG AGC 118
Met Ser
1CTG ACT TCG CTT TTA AAC CCA AAA AGC CTA GAA GAT TTT TTA GGC CAA 166Leu Thr Ser Leu Leu Asn Pro Lys Ser Leu Glu Asp Phe Leu Gly Gln
5 10 15GAG CAT TTA GTA GGG AAA GAC GCC CCC TTA TTT AAA GCC CTA CAA TCC 214Glu His Leu Val Gly Lys Asp Ala Pro Leu Phe Lys Ala Leu Gln Ser
20 25 30AAA CAC TTC CCC CAT GCC TTT TTC TAT GGC CCT CCT GGC GTG GGT AAA 262Lys His Phe Pro His Ala Phe Phe Tyr Gly Pro Pro Gly Val Gly Lys35 40 45 50ACA AGC CTG GCT CAA ATC ATC GCC TAT ATG CTA GAG CGC CCC ATT CTT 310Thr Ser Leu Ala Gln Ile Ile Ala Tyr Met Leu Glu Arg Pro Ile Leu
55 60 65TTA TTC AAT GCG ACG GAT TTT AAA TTA GAG GAT TTG CGC CTT AAG CTT 358Leu Phe Asn Ala Thr Asp Phe Lys Leu Glu Asp Leu Arg Leu Lys Leu
70 75 80AAA AAT TAC CAA AAT ACC CTT TTA AAA CCC GTT GTT TTT ATT GAT GAA 406Lys Asn Tyr Gln Asn Thr Leu Leu Lys Pro Val Val Phe Ile Asp Glu
85 90 95ACC CAC AGA TTG AAT AAA ACC CAA CAA GAA TTT TTA CTC CCC ATT ATG 454Thr His Arg Leu Asn Lys Thr Gln Gln Glu Phe Leu Leu Pro Ile Met
100 105 110GAA AAA GAT CAC GCT TTA ATT TTA GGG GCT AGC ACG CAA GAT CCT AAT 502Glu Lys Asp His Ala Leu Ile Leu Gly Ala Ser Thr Gln Asp Pro Asn115 120 125 130TAC AGC CTA AGC CAT GCG ATC CGA TCA AGA AGT TTT ATT TTT GAA TTA 550Tyr Ser Leu Ser His Ala Ile Arg Ser Arg Ser Phe Ile Phe Glu Leu
135 140 145ACC CCC CTA AAC AAG AGC GAT TTA GAC AGG CTT TGC GCT AAA GCT TTA 598Thr Pro Leu Asn Lys Ser Asp Leu Asp Arg Leu Cys Ala Lys Ala Leu
150 155 160ACA TTG CTC AAA AAA CAA ATA GAG CCT GGC GCT AAA ACC TAT CTT TTA 646Thr Leu Leu Lys Lys Gln Ile Glu Pro Gly Ala Lys Thr Tyr Leu Leu
165 170 175AAC AAC AGC GCT GGC GAC GCT AGA GCG TTA TTA AAC CTT TTA GAT TTG 694Asn Asn Ser Ala Gly Asp Ala Arg Ala Leu Leu Asn Leu Leu Asp Leu
180 185 190AGC GCT AAA ATA GAA GAT CCT ATC ACT TTA AAA ACG CTA CAA TCC TTA 742Ser Ala Lys Ile Glu Asp Pro Ile Thr Leu Lys Thr Leu Gln Ser Leu195 200 205 210CGG CCT CAT AGC CTA AAT GAT GGA TCT TAT AGC GAT GAT ACG CAT TAT 790Arg Pro His Ser Leu Asn Asp Gly Ser Tyr Ser Asp Asp Thr His Tyr
215 220 225AAC CTT ACT AGC GCG TTA ATC AAA TCT TTA AGA GGG AGC GAT GAA AAC 838Asn Leu Thr Ser Ala Leu Ile Lys Ser Leu Arg Gly Ser Asp Glu Asn
230 235 240GCT TCC ATC TAT TAT CTG GCG CGC TTG ATT GCT GGC GGG GAA AAC CCG 886Ala Ser Ile Tyr Tyr Leu Ala Arg Leu Ile Ala Gly Gly Glu Asn Pro
245 250 255GAA TTT ATC GCC AGA AGG CTG GTG ATT TTT GCG AGC GAA GAT ATI GGT 934Glu Phe Ile Ala Arg Arg Leu Val Ile Phe Ala Ser Glu Asp Ile Gly
260 265 270AAC GCT AAC CCG AAC GCC CTT AAT TTA GCC GCT TCT TGT TTG TTT GCA 982Asn Ala AsnPro Asn Ala Leu Asn Leu Ala Ala Ser Cys Leu Phe Ala275 280 285 290GTC AAA CAA ATC GGC TAC CCT GAA GCG CGC ATC ATT TTA AGC CAA TGC 1030Val Lys Gln Ile Gly Tyr Pro Glu Ala Arg Ile Ile Leu Ser Gln Cys
295 300 305GTG ATT TAT CTG GCT TGT TCG CCC AAG TCT AAC ACG GCT TAT AGA GCG 1078Val Ile Tyr Leu Ala Cys Ser Pro Lys Ser Asn Thr Ala Tyr Arg Ala
310 315 320ATC AAT CAG GCT TTG GAT TGC GTT CAA AAA GGC TCA GTC TAC CCT ATT 1126Ile Asn Gln Ala Leu Asp Cys Val Gln Lys Gly Ser Leu Tyr Pro Ile
325 330 335CCT AAA CAC CTG CTG CCT AAC GCT AAA GAT TAC CTT TAC CCG CAT GAT 1174Pro Lys His Leu Leu Pro Asn Ala Lys Asp Tyr Leu Tyr Pro His Asp
340 345 350TAT AAC GGC TAT GTC AAA CAA GAT TAT TTG GAA AAA CCC CTA GAT TTG 1222Tyr Asn Gly Tyr Val Lys Gln Asp Tyr Leu Glu Lys Pro Leu Asp Leu355 360 365 370GTT TCT TCT CAA GGC ATA GGA TTT GAA AAA ACC CTT TTA GAA TGG CTT 1270Val Ser Ser Gln Gly Ile Gly Phe Glu Lys Thr Leu Leu Glu Trp Leu
375 380 385GAT AAG ATA AGA AAT TGATCTTATA AGTTACATTA AAATGCGACA ATGGTAATAA A 1326Asp Lys Ile Arg Asn
390AAATCAATAT TTTTGGATTG AATT 1350
(2) Sequence 494 data:
(i) sequence characteristics:
(A) length: 391 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 494: met Ser Leu Thr Ser Leu Leu Asn Pro Lys Ser Leu Glu Asp Phe Leu 151015 Gly Gln Glu His Leu Val Gly Lys Asp Ala Pro Leu Phe Lys Ala Leu
20 25 30Gln Ser Lys His Phe Pro His Ala Phe Phe Tyr Gly Pro Pro Gly Val
35 40 45Gly Lys Thr Ser Leu Ala Gln Ile Ile Ala Tyr Met Leu Glu Arg Pro
50 55 60Ile Leu Leu Phe Asn Ala Thr Asp Phe Lys Leu Glu Asp Leu Arg Leu65 70 75 80Lys Leu Lys Asn Tyr Gln Asn Thr Leu Leu Lys Pro Val Val Phe Ile
85 90 95Asp Glu Thr His Arg Leu Asn Lys Thr Gln Gln Glu Phe Leu Leu Pro
100 105 110Ile Met Glu Lys Asp His Ala Leu Ile Leu Gly Ala Ser Thr Gln Asp
115 120 125Pro Asn Tyr Ser Leu Ser His Ala Ile Arg Ser Arg Ser Phe Ile Phe
130 135 140Glu Leu Thr Pro Leu Asn Lys Ser Asp Leu Asp Arg Leu Cys Ala Lys145 150 155 160Ala Leu Thr Leu Leu Lys Lys Gln Ile Glu Pro Gly Ala Lys Thr Tyr
165 170 175Leu Leu Asn Asn Ser Ala Gly Asp Ala Arg Ala Leu Leu Asn Leu Leu
180 185 190Asp Leu Ser Ala Lys Ile Glu Asp Pro Ile Thr Leu Lys Thr Leu Gln
195 200 205Ser Leu Arg Pro His Ser Leu Asn Asp Gly Ser Tyr Ser Asp Asp Thr
210 215 220His Tyr Asn Leu Thr Ser Ala Leu Ile Lys Ser Leu Arg Gly Ser Asp225 230 235 240Glu Asn Ala Ser Ile Tyr Tyr Leu Ala Arg Leu Ile Ala Gly Gly Glu
245 250 255Asn Pro Glu Phe Ile Ala Arg Arg Leu Val Ile Phe Ala Ser Glu Asp
260 265 270Ile Glv Asn Ala Asn Pro Asn Ala Leu Asn Leu Ala Ala Ser Cys Leu
275 280 285Phe Ala Val Lys Gln Ile Gly Tyr Pro Glu Ala Arg Ile Ile Leu Ser
290 295 300Gln Cys Val Ile Tyr Leu Ala Cys Ser Pro Lys Ser Asn Thr Ala Tyr305 310 315 320Arg Ala Ile Asn Gln Ala Leu Asp Cys Val Gln Lys Gly Ser Leu Tyr
325 330 335Pro Ile Pro Lys His Leu Leu Pro Asn Ala Lys Asp Tyr Leu Tyr Pro
340 345 350His Asp Tyr Asn Gly Tyr Val Lys Gln Asp Tyr Leu Glu Lys Pro Leu
355 360 365Asp Leu Val Ser Ser Gln Gly Ile Gly Phe Glu Lys Thr Leu Leu Glu
370 375 380Trp Leu Asp Lys Ile Arg Asn385 390
(2) Sequence 495 data:
(i) sequence characteristics:
(A) length: 869bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 76...759
(D) Other information:
(xi) Description of the sequence: sequence 495: AAGAAACTTT TAACAAACAA TTCAAGGGAT TTGGCGATTT TGGGTCTTAA AAAATATGCT 60ATTTTATGGT CTTTA ATG GGG TTT TAT GCA GGA TTG AAC GCG CTT GAT TAT 111
Met Gly Phe Tyr Ala Gly Leu Asn Ala Leu Asp Tyr
1 5 10GAC ACC ATA GAC CCA AAA TAC TAC AAG TAT ATC AAG TAT TAT AAA GCC 159Asp Thr Ile Asp Pro Lys Tyr Tyr Lys Tyr Ile Lys Tyr Tyr Lys Ala
15 20 25TAT GAG GAT AAA GAA GTT GAA GAA TTG ATC AGA GAC TTA AAA AGG GCG 207Tyr Glu Asp Lys Glu Val Glu Glu Leu Ile Arg Asp Leu Lys Arg Ala
30 35 40AAC GCT AAA AGC GGG CTT ATT TTA GGG ATC AAT ACC GGG TTT TTT TAC 255Asn Ala Lys Ser Gly Leu Ile Leu Gly Ile Asn Thr Gly Phe Phe Tyr45 50 55 60AAT CAT GAA ATC ATG GTT AGA ACT AAT AGC TCT AGC ATC ACG GGG AAT 303Asn His Glu Ile Met Val Arg Thr Asn Ser Ser Ser Ile Thr Gly Asn
65 70 75ATT TTA AAT TAT TTG TTC GCT TAC GGC TTG CGT TTT GGC TAT CAA ACT 351Ile Leu Asn Tyr Leu Phe Ala Tyr Gly Leu Arg Phe Gly Tyr Gln Thr
80 85 90TTC AGG CCG TCG TTT TTT GCG CGC TTG GTC AAG CCA AAT ATC ATT GGC 399Phe Arg Pro Ser Phe Phe Ala Arg Leu Val Lys Pro Asn Ile Ile Gly
95 100105AGG CGC ATT TAT ATC CAA TAT TAT GGA GGA GCT CCT AAA AAA GCG GGC 447Arg Arg Ile Tyr Ile Gln Tyr Tyr Gly Gly Ala Pro Lys Lys Ala Gly
110 115 120TTT GGG GAT GTA GGG TTT CAA TCG GTT ATG CTG AAT GGG GAT TTT TTA 495Phe Gly Asp Val Gly Phe Gln Ser Val Met Leu Asn Gly Asp Phe Leu125 130 135 140TTG GAT TIT CCT TTG CCT TTT GTG GGG AAA TAC CTT TAT ATG GGG GGT 543Leu Asp Phe Pro Leu Pro Phe Val Gly Lys Tyr Leu Tyr Met Gly Gly
145 150 155TAT ATG GGT TTA GGT TTG GGG GTT GTA GCG CAT GGG GTG AAT TAC ACG 591Tyr Met Gly Leu Gly Leu Gly Val Val Ala His Gly Val Asn Tyr Thr
160 165 170GCG GAA TGG GGG ATG TCT TTT AAC GCA GGA TTG GCT CTA ACG GTA TTA 639Ala Glu Trp Gly Met Ser Phe Asn Ala Gly Leu Ala Leu Thr Val Leu
175 180 185GAA AAA AAC CGC ATT GAA TTT GGA TTT AAA ATT TTG AAT AAT TTC CCT 687Glu Lys Asn Arg Ile Glu Phe Gly Phe Lys Ile Leu Asn Asn Phe Pro
190 195 200TTT TTG CAA TCT AAT TCT TCA AAA GAG ACT TGG TGG GGA GCT ATG GCA 735Phe Leu Gln Ser Asn Ser Ser Lys Glu Thr Trp Trp Gly Ala Met Ala205 210 215 220AAC ATT GGG TAT CAA TAT GTG TTC TAAAAAAATA AGAAATCTCA TTTTATGCTT 789Asn Ile Gly Tyr Gln Tyr Val Phe
225TGGTTTTATG TTGGGCTTGC ACGCTGAAGA AAATACGACT GAAGGAAATA TGACTGAAGA 849AAATATCTCT AAAGACGCTC 869
(2) Data of sequence 496:
(i) sequence characteristics:
(A) length: 228 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 496: met Gly Phe Tyr Ala Gly Leu Asn Ala Leu Asp Tyr Asp Thr Ile Asp 151015 Pro Lys Tyr Tyr Lys Tyr Ile Lys Tyr Tyr Lys Ala Tyr Glu Asp Lys
20 25 30Glu Val Glu Glu Leu Ile Arg Asp Leu Lys Arg Ala Asn Ala Lys Ser
35 40 45Gly Leu Ile Leu Gly Ile Asn Thr Gly Phe Phe Tyr Asn His Glu Ile
50 55 60Met Val Arg Thr Asn Ser Ser Ser Ile Thr Gly Asn Ile Leu Asn Tyr65 70 75 80Leu Phe Ala Tyr Gly Leu Arg Phe Gly Tyr Gln Thr Phe Arg Pro Ser
85 90 95Phe Phe Ala Arg Leu Val Lys Pro Asn lle lle Gly Arg Arg Ile Tyr
100 105 110Ile Gln Tyr Tyr Gly Gly Ala Pro Lys Lys Ala Gly Phe Gly Asp Val
115 120 125Gly Phe Gln Ser Val Met Leu Asn Gly Asp Phe Leu Leu Asp Phe Pro
130 135 140Leu Pro Phe Val Gly Lys Tyr Leu Tyr Met Gly Gly Tyr Met Gly Leu145 150 155 160Gly Leu Gly Val Val Ala His Gly Val Asn Tyr Thr Ala Glu Trp Gly
165 170 175Met Ser Phe Asn Ala Gly Leu Ala Leu Thr Val Leu Glu Lys Asn Arg
180 185190Ile Glu Phe Gly Phe Lys Ile Leu Asn Asn Phe Pro Phe Leu Gln Ser
195 200 205Asn Ser Ser Lys Glu Thr Trp Trp Gly Ala Met Ala Asn Ile Gly Tyr
210 215 220Gln Tyr Val Phe225
(2) Sequence 497 data:
(i) sequence characteristics:
(A) length: 1171bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 89...1096
(D) Other information:
(xi) Description of the sequence: sequence 497: GGAAAGAATT GATTCAAAAC GCTATCAAAC AATACGCTGA TGATGTGAAA AAGGGAAACT 60TCCCTAACGA ATTAGAAAGT TATCATTA ATG AAA GAA CGG ATA GTC AAT TTA 112
Met Lys Glu Arg Ile Val Asn Leu
1 5GAA ACT TTG GAT TTT GAA ATT TCT CAA GAA GTG AGT TTG CGC CCT AGT 160Glu Thr Leu Asp Phe Glu Ile Ser Gln Glu Val Ser Leu Arg Pro Ser
10 15 20CTT TGG GAA GAT TTT ATC GGT CAA GAA AAG ATT AAA AGC AAT TTG CAA 208Leu Trp Glu Asp Phe Ile Gly Gln Glu Lys Ile Lys Ser Asn Leu Gln25 30 35 40ATT TCT ATT TGC GCG GCT AAA AAA CGC CAA GAA AGT TTG GAT CAC ATG 256Ile Ser Ile Cys Ala Ala Lys Lys Arg Gln Glu Ser Leu Asp His Met
45 50 55CTT TTT TTT GGC CCG CCC GGT TTG GGT AAA ACT TCA ATC AGC CAT ATC 304Leu Phe Phe Gly Pro Pro Gly Leu Gly Lys Thr Ser Ile Ser His Ile
60 65 70ATC GCT AAA GAA ATG GAA ACC AAT ATC AAG ATC ACC GCC GCT CCC ATG 352Ile Ala Lys Glu Met Glu Thr Asn Ile Lys Ile Thr Ala Ala Pro Met
75 80 85ATA GAA AAA AGC GGT GAT TTA GCC GCC ATT TTG ACC AAT TTG CAA GCT 400Ile Glu Lys Ser Gly Asp Leu Ala Ala Ile Leu Thr Asn Leu Gln Ala
90 95 100AAA GAC ATT CTT TTT ATT GAT GAA ATC CAC CGG CTC AGC CCA GCG ATT 448Lys Asp Ile Leu Phe Ile Asp Glu Ile His Arg Leu Ser Pro Ala Ile105 110 115 120GAA GAG GTT TTA TAC CCG GCG ATG GAA GAT TTT AGG TTG GAT ATT ATC 496Glu Glu Val Leu Tyr Pro Ala Met Glu Asp Phe Arg Leu Asp Ile Ile
125 130 135ATA GGC TCA GGC CCA GCG GCT CAA ACC ATT AAA ATT GAT TTA CCC CCT 544Ile Gly Ser Gly Pro Ala Ala Gln Thr Ile Lys Ile Asp Leu Pro Pro
140 145 150TTC ACT CTC ATC GGC GCT ACC ACC AGA GCC GGA ATG CTC TCT AAC CCC 592Phe Thr Leu Ile Gly Ala Thr Thr Arg Ala Gly Met Leu Ser Asn Pro
155 160 165TTA AGA GAC AGA TTT GGC ATG AGT TTT AGA ATG CAA TTT TAT AAC CCT 640Leu Arg Asp Arg Phe Gly Met Ser Phe Arg Met Gln Phe Tyr Asn Pro
170 175 180AGC GAA CTG GCC CTC ATC ATT AAA AAA GCT GCC GTT AAA CTC AAC CAA 688Ser Glu Leu Ala Leu Ile Ile Lys Lys Ala Ala Val Lys Leu Asn Gln185 190 195 200GAC ATC AAA CAA GAA AGT GCT GAT GAA ATC GCTAAA AGG AGT AGA GGC 736Asp Ile Lys Gln Glu Ser Ala Asp Glu Ile Ala Lys Arg Ser Arg Gly
205 210 215ACG CCA AGG ATC GCT TTA AGG CTT TTA AAA AGG GTG CGC GAT TTT GCG 784Thr Pro Arg Ile Ala Leu Arg Leu Leu Lys Arg Val Arg Asp Phe Ala
220 225 230CTA GTC AAA AAT TCA AGC TTG ATG GAT TTA AAC ATC ACT TTG CAT GCT 832Leu Val Lys Asn Ser Ser Leu Met Asp Leu Asn Ile Thr Leu His Ala
235 240 245TTG AAT GAA TTA GGC GTG AAT GAA TTA GGC TTT GAT GAA GCG GAT TTG 880Leu Asn Glu Leu Gly Val Asn Glu Leu Gly Phe Asp Glu Ala Asp Leu
250 255 260GCG TAT TTA TCT TTG TTG GCT AAC GCT CAA GGA AAG CCG GTG GGT TTG 928Ala Tyr Leu Ser Leu Leu Ala Asn Ala Gln Gly Lys Pro Val Gly Leu265 270 275 280AAC ACG ATT GCA GCA TCT ATG AGA GAA GAT GAA GGC ACG ATT GAA GAC 976Asn Thr Ile Ala Ala Ser Met Arg Glu Asp Glu Gly Thr Ile Glu Asp
285 290 295GTG ATT GAG CCT TTT TTA CTC GCT AAT GGT TAT TTA GAG CGC ACC GCT 1024Val Ile Glu Pro Phe Leu Leu Ala Asn Gly Tyr Leu Glu Arg Thr Ala
300 305 310AAA GGC AGA ATC GCC ACG CCT AAA ACC CAT GAG CTC TTA AAA ATC CCC 1072Lys Gly Arg Ile Ala Thr Pro Lys Thr His Glu Leu Leu Lys Ile Pro
315 320 325ACT TTA AAC CCC CAA ACT TTA TTT TAATCTTGTT TAGAAAGAAA ATTACACTAC 1126Thr Leu Asn Pro Gln Thr Leu Phe
330 335AATAACGATA AAATTTTAAA GGGTGTAAAA GTAGATTGTT ATGTT 1171
(2) Sequence 498 data:
(i) sequence characteristics:
(A) length: 336 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 498: met Lys Glu Arg Ile Val Asn Leu Glu Thr Leu Asp Phe Glu Ile Ser 151015 Gln Glu Val Ser Leu Arg Pro Ser Leu Trp Glu Asp Phe Ile Gly Gln
20 25 30Glu Lys Ile Lys Ser Asn Leu Gln Ile Ser Ile Cys Ala Ala Lys Lys
35 40 45Arg Gln Glu Ser Leu Asp His Met Leu Phe Phe Gly Pro Pro Gly Leu
50 55 60Gly Lys Thr Ser Ile Ser His Ile Ile Ala Lys Glu Met Glu Thr Asn65 70 75 80Ile Lys Ile Thr Ala Ala Pro Met Ile Glu Lys Ser Gly Asp Leu Ala
85 90 95Ala Ile Leu Thr Asn Leu Gln Ala Lys Asp Ile Leu Phe Ile Asp Glu
100 105 110Ile His Arg Leu Ser Pro Ala Ile Glu Glu Val Leu Tyr Pro Ala Met
115 120 125Glu Asp Phe Arg Leu Asp Ile Ile Ile Gly Ser Gly Pro Ala Ala Gln
130 135 140Thr Ile Lys Ile Asp Leu Pro Pro Phe Thr Leu Ile Gly Ala Thr Thr145 150 155 160Arg Ala Gly Met Leu Ser Asn Pro Leu Arg Asp Arg Phe Gly Met Ser
165 170175Phe Arg Met Gln Phe Tyr Asn Pro Ser Glu Leu Ala Leu Ile Ile Lys
180 185 190Lys Ala Ala Val Lys Leu Asn Gln Asp Ile Lys Gln Glu Ser Ala Asp
195 200 205Glu Ile Ala Lys Arg Ser Arg Gly Thr Pro Arg Ile Ala Leu Arg Leu
210 215 220Leu Lys Arg Val Arg Asp Phe Ala Leu Val Lys Asn Ser Ser Leu Met225 230 235 240Asp Leu Asn Ile Thr Leu His Ala Leu Asn Glu Leu Gly Val Asn Glu
245 250 255Leu Gly Phe Asp Glu Ala Asp Leu Ala Tyr Leu Ser Leu Leu Ala Asn
260 265 270Ala Gln Gly Lys Pro Val Gly Leu Asn Thr Ile Ala Ala Ser Met Arg
275 280 285Glu Asp Glu Gly Thr Ile Glu Asp Val Ile Glu Pro Phe Leu Leu Ala
290 295 300Asn Gly Tyr Leu Glu Arg Thr Ala Lys Gly Arg Ile Ala Thr Pro Lys305 310 315 320Thr His Glu Leu Leu Lys Ile Pro Thr Leu Asn Pro Gln Thr Leu Phe
325 330 335
(2) Data of sequence 499:
(i) sequence characteristics:
(A) length: 989 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 111...869
(D) Other information:
(xi) Description of the sequence: sequence 499: AGTTTCCAAT GAAGAAGCCT TAAACAAAGA AGTTTCAAGC GATGAATCCC CTAAAGAAGT 60CCAATTAGCA ACCGATAACA ACACCAAAGA ACACGACAAA GAAAAAGAGA ATG TTT 116
Met Phe
1GAA GAT TTA AAA CCG CAT TTA CAG GAA TTA AGA AAG CGT TTG ATG GTT 164Glu Asp Leu Lys Pro His Leu Gln Glu Leu Arg Lys Arg Leu Met Val
5 10 15TCT GTA GGA ACG ATT CTA GTG GCG TTT TTG GGG TGC TTT CAT TTT TGG 212Ser Val Gly Thr Ile Leu Val Ala Phe Leu Gly Cys Phe His Phe Trp
20 25 30AAA AGT ATT TTT GAA TTT GTT AAA AAT TCC TAT AAA GGC ACG CTC ATT 260Lys Ser Ile Phe Glu Phe Val Lys Asn Ser Tyr Lys Gly Thr Leu Ile35 40 45 50CAG CTC TCC CCT ATT GAA GGG GTC ATG GTA GCG GTT AAA ATC AGT TTT 308Gln Leu Ser Pro Ile Glu Gly Val Met Val Ala Val Lys Ile Ser Phe
55 60 65TCA GCC GCT ATC GTC ATT TCC ATG CCC ATT ATT TTT TGG CAA TTA TGG 356Ser Ala Ala Ile Val Ile Ser Met Pro Ile Ile Phe Trp Gln Leu Trp
70 75 80CTC TTT ATC GCT CCA GGG CTT TAC AAG AAT GAA AAA AAA GTG ATT TTG 404Leu Phe Ile Ala Pro Gly Leu Tyr Lys Asn Glu Lys Lys Val Ile Leu
85 90 95CCT TTT GTG TTT TTT GGG AGT GGG ATG TTT TTG ATT GGG GCG GCG TTT 452Pro Phe Val Phe Phe Gly Ser Gly Met Phe Leu Ile Gly Ala Ala Phe
100 105 110TCT TAT TAT GTG GTG TTC CCT TTC ATT ATT GAA TAC TTA GCC ACT TTT 500Ser Tyr Tyr Val Val Phe Pro Phe Ile Ile Glu Tyr Leu Ala Thr Phe115 120 125 130GGG AGC GAT GTG TTT GCG GCT AAT ATT TCT GCG TCC AGT TAC GTG AGC 548Gly Ser Asp Val Phe Ala Ala Asn Ile Ser Ala Ser Ser Tyr Val Ser
135 140 145TTT TTC ACG CGC TTG ATT TTA GGC TTT GGC GTG GCG TTT GAA TTG CCT 596Phe Phe Thr Arg Leu Ile Leu Gly Phe Gly Val Ala Phe Glu Leu Pro
150 155 160GTT TTG GCG TAT TTT TTG GCT AAA GTG GGC TTG ATT ACT GAT GCG AGC 644Val Leu Ala Tyr Phe Leu Ala Lys Val Gly Leu Ile Thr Asp Ala Ser
165 170 175TTG AAA GCG TAT TTT AAA TAC GCT ATT GTA GTG ATT TTT ATT GTA GCA 692Leu Lys Ala Tyr Phe Lys Tyr Ala Ile Val Val Ile Phe Ile Val Ala
180 185 190GCC ATT ATC ACT CCC CCT GAT GTG GTG AGT CAA ATC TTT ATG GCG TTG 740Ala Ile Ile Thr Pro Pro Asp Val Val Ser Gln Ile Phe Met Ala Leu195 200 205 210CCC TTA GTG GGG CTT TAT GGG CTT TCT ATT TTA ATC GCC AAA ATG GTC 788Pro Leu Val Gly Leu Tyr Gly Leu Ser Ile Leu Ile Ala Lys Met Val
215 220 225AAT CCG GCT CCC AAA GAT AAC GAA AAT AAC AAC GAA AAT AAT AAC GAA 836Asn Pro Ala Pro Lys Asp Asn Glu Asn Asn Asn Glu Asn Asn Asn Glu
230 235 240AAT AAC ACC AAA GAG AAT ACA AAG AGC GAG TCG TAGTTGAAAG AATTTGATTT 889Asn Asn Thr Lys Glu Asn Thr Lys Ser Glu Ser
245 250AGAAAGCTAT GATTATTATT TGCCTAAGGA ATTGATCGCA AGCTACCCCG TTTTGCCCAA 949AGAAAAGGCT AAATTACTCG TCTATGAAAG GCGTTCGCAA 989
(2) Sequence 500 data:
(i) sequence characteristics:
(A) length: 253 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 500: met Phe Glu Asp Leu Lys Pro His Leu Gln Glu Leu Arg Lys Arg Leu 151015 Met Val Ser Val Gly Thr Ile Leu Val Ala Phe Leu Gly Cys Phe His
20 25 30Phe Trp Lys Ser Ile Phe Glu Phe Val Lys Asn Ser Tyr Lys Gly Thr
35 40 45Leu Ile Gln Leu Ser Pro Ile Glu Gly Val Met Val Ala Val Lys Ile
50 55 60Ser Phe Ser Ala Ala Ile Val Ile Ser Met Pro Ile Ile Phe Trp Gln65 70 75 80Leu Trp Leu Phe Ile Ala Pro Gly Leu Tyr Lys Asn Glu Lys Lys Val
85 90 95Ile Leu Pro Phe Val Phe Phe Gly Ser Gly Met Phe Leu Ile Gly Ala
100 105 110Ala Phe Ser Tyr Tyr Val Val Phe Pro Phe Ile Ile Glu Tyr Leu Ala
115 120 125Thr Phe Gly Ser Asp Val Phe Ala Ala Asn Ile Ser Ala Ser Ser Tyr
130 135 140Val Ser Phe Phe Thr Arg Leu Ile Leu Gly Phe Gly Val Ala Phe Glu145 150 155160Leu Pro Val Leu Ala Tyr Phe Leu Ala Lys Val Gly Leu Ile Thr Asp
165 170 175Ala Ser Leu Lys Ala Tyr Phe Lys Tyr Ala Ile Val Val Ile Phe Ile
180 185 190Val Ala Ala Ile Ile Thr Pro Pro Asp Val Val Ser Gln Ile Phe Met
195 200 205Ala Leu Pro Leu Val Gly Leu Tyr Gly Leu Ser Ile Leu Ile Ala Lys
210 215 220Met Val Asn Pro Ala Pro Lys Asp Asn Glu Asn Asn Asn Glu Asn Asn225 230 235 240Asn Glu Asn Asn Thr Lys Glu Asn Thr Lys Ser Glu Ser
245 250
(2) Sequence 501 data:
(i) sequence characteristics:
(A) length: 655bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...600
(D) Other information:
(xi) Description of the sequence: sequence 501: GTGCATTATT TAAGAATTTT AATACTGAGT ATG AGT TTT TTA AAT ATT TTA AAT 54
Met Ser Phe Leu Asn Ile Leu Asn
1 5GCT GAA AAT TTG AGT TAT ATG TCT TCT TCT TAT CAA ATA GGC ACG GTG 102Ala Glu Asn Leu Ser Tyr Met Ser Ser Ser Tyr Gln Ile Gly Thr Val
10 15 20TTT ATG CGC CCT TTA AAC ACC AAC AAG CTT TTA CAA GGG GCT TCA ATC 150Phe Met Arg Pro Leu Asn Thr Asn Lys Leu Leu Gln Gly Ala Ser Ile25 30 35 40CTT CAA GGC TAT GAA GTG AAT CCT AAA AAC GAT TGG GCT TAT TCT AGG 198Leu Gln Gly Tyr Glu Val Asn Pro Lys Asn Asp Trp Ala Tyr Ser Arg
45 50 55TAT TAT TTC TTT ATA GAT TAT GGC AAT GTG CTT TTT AAT AAT GAC TCT 246Tyr Tyr Phe Phe Ile Asp Tyr Gly Asn Val Leu Phe Asn Asn Asp Ser
60 65 70ACT TTA CAA GCG AAC ATG TTC ACT TAT GGG GTG GGA GGG GAT TTT ATG 294Thr Leu Gln Ala Asn Met Phe Thr Tyr Gly Val Gly Gly Asp Phe Met
75 80 85GTC GCC TAC GCT AAA AAC CCT ATC AAC CGC TGG GCT TTT TTC TTT GGC 342Val Ala Tyr Ala Lys Asn Pro Ile Asn Arg Trp Ala Phe Phe Phe Gly
90 95 100TTG CAA CTG GCC GCT AAC ACA TGG ATA CTC AAC AAT AAA GTC AAA GAT 390Leu Gln Leu Ala Ala Asn Thr Trp Ile Leu Asn Asn Lys Val Lys Asp105 110 115 120TTG GTG GTG AAT ACT TGG GAT TCA TTA AAA GAT TTC AAT CAT CAC AAC 438Leu Val Val Asn Thr Trp Asp Ser Leu Lys Asp Phe Asn Phe His Asn
125 130 135ACT TAT TTC AGG GCT ATT GGG AAG TTT GGG GTG CAG TTT CGC ACG ATC 486Thr Tyr Phe Arg Ala Ile Gly Lys Phe Gly Val Gln Phe Arg Thr Ile
140 145 150GTT TTG TAT CAT AAG GTG GAT GTA GAA ATT GGC ATG AAA ATC TTT CTA 534Val Leu Tyr His Lys Val Asp Val Glu Ile Gly Met Lys Ile Phe Leu
155 160165ACT CCT GAA AGG CGC AGT TTG TTT GAA AGG AGC TTT TTG TTT TTT GTT 582Thr Pro Glu Arg Arg Ser Leu Phe Glu Arg Ser Phe Leu Phe Phe Val
170 175 180TCG CAT TCG TGG CAT TTT TAAATGGCGG AGAGAGAGGG ATTCGAACCC TCGAAGGC 638Ser His Ser Trp His Phe185 190TTGCACCTTA CACGCGT 655
(2) Sequence 502 data:
(i) sequence characteristics:
(A) length: 190 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 502: met Ser Phe Leu Asn Ile Leu Asn Ala Glu Asn Leu Ser Tyr Met Ser 151015 Ser Ser Tyr Gln Ile Gly Thr Val Phe Met Arg Pro Leu Asn Thr Asn
20 25 30Lys Leu Leu Gln Gly Ala Ser Ile Leu Gln Gly Tyr Glu Val Asn Pro
35 40 45Lys Asn Asp Trp Ala Tyr Ser Arg Tyr Tyr Phe Phe Ile Asp Tyr Gly
50 55 60Asn Val Leu Phe Asn Asn Asp Ser Thr Leu Gln Ala Asn Met Phe Thr65 70 75 80Tyr Gly Val Gly Gly Asp Phe Met Val Ala Tyr Ala Lys Asn Pro Ile
85 90 95Asn Arg Trp Ala Phe Phe Phe Gly Leu Gln Leu Ala Ala Asn Thr Trp
100 105 110Ile Leu Asn Asn Lys Val Lys Asp Leu Val Val Asn Thr Trp Asp Ser
115 120 125Leu Lys Asp Phe Asn Phe His Asn Thr Tyr Phe Arg Ala Ile Gly Lys
130 135 140Phe Gly Val Gln Phe Arg Thr Ile Val Leu Tyr His Lys Val Asp Val145 150 155 160Glu Ile Gly Met Lys Ile Phe Leu Thr Pro Glu Arg Arg Ser Leu Phe
165 170 175Glu Arg Ser Phe Leu Phe Phe Val Ser His Ser Trp His Phe
180 185 190
(2) Sequence 503 data:
(i) sequence characteristics:
(A) length: 830bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...714
(D) Other information:
(xi) Description of the sequence: sequence 503: AAAGCACTAT ATTAAGATTA GGATCATTTA ATG GCA GAT AAA GAA ATA CTG ATT 54
Met Ala Asp Lys Glu Ile Leu Ile
1 5TTT GTA GAA GGT CCA AGC GAT AAG GTG TTT TTA GAA GTT TAT CTG TAT 102Phe Val Glu Gly Pro Ser Asp Lys Val Phe Leu Glu Val Tyr Leu Tyr
10 15 20TTT CTA GAA AGA TTT CCA ATC AAA AAC TTT AAA GTG CAA AAT GTA GAT 150Phe Leu Glu Arg Phe Pro Ile Lys Asn Phe Lys Val Gln Asn Val Asp25 30 35 40GGA AAA GAT AAC CTG TCT AAA CGA TTG CTT GAA ATT GAA AAA TAC GAT 198Gly Lys Asp Asn Leu Ser Lys Arg Leu Leu Glu Ile Glu Lys Tyr Asp
45 50 55AAA ACA CTT ATC ATT TTT GAT GCG GAT AAA GAC TAT GAG AGT AAT AAA 246Lys Thr Leu Ile Ile Phe Asp Ala Asp Lys Asp Tyr Glu Ser Asn Lys
60 65 70AAA GAG ATT TTA AAA ATT GTA TCA GAA TCG AAA CAA ACT ATT TCA GAA 294Lys Glu Ile Leu Lys Ile Val Ser Glu Ser Lys Gln Thr Ile Ser Glu
75 80 85GAA CAA ATT TTT TTA TTT CCT AAT AAT CAA GAT GAT GGC GAT TTA GAA 342Glu Gln Ile Phe Leu Phe Pro Asn Asn Gln Asp Asp Gly Asp Leu Glu
90 95 100ACC CTA TTA TTA AAG ATT GCT AAC CAC AAA GAG TTC ATA AAT TGT TTT 390Thr Leu Leu Leu Lys Ile Ala Asn His Lys Glu Phe Ile Asn Cys Phe105 110 115 120GAA AGC TAT TTG GAT TGT ATT AAA AAG AAA GAA CAT TAC AAA CCG ATT 438Glu Ser Tyr Leu Asp Cys Ile Lys Lys Lys Glu His Tyr Lys Pro Ile
125 130 135AAA AAC ATA AGA AAA AGT AAG TGG TAT GCC TAT TTA GAA GCG CTT GGA 486Lys Asn Ile Arg Lys Ser Lys Trp Tyr Ala Tyr Leu Glu Ala Leu Gly
140 145 150TTA GAA AAA TTT TTC CAA TAC ACA TGG GAC ACA AAG AAA AAG AAT AAT 534Leu Glu Lys Phe Phe Gln Tyr Thr Trp Asp Thr Lys Lys Lys Asn Asn
155 160 165AAA AAA AAG CTT ATC ATT GAC GAT AAA GAT GGA GAT GAG ATT GAG ATA 582Lys Lys Lys Leu Ile Ile Asp Asp Lys Asp Gly Asp Glu Ile Glu Ile
170175 180AAA GAT CAA TAT AAA GGA GAT TAT GAA GAA CTA AAA AAA GTT CTT GAT 630Lys Asp Gln Tyr Lys Gly Asp Tyr Glu Glu Leu Lys Lys Val Leu Asp185 190 195 200CTT AAC TCA AAA TCT CTT ATT CCC CTT AAA AAT TTT TTA GGG CAA TTT 678Leu Asn Ser Lys Ser Leu Ile Pro Leu Lys Asn Phe Leu Gly Gln Phe
205 210 215GCA GAA AAT AAT CAA AAA ACA AAT CCT AAA ATT TTC TAATTTAACA AAATAT 730Ala Glu Asn Asn Gln Lys Thr Asn Pro Lys Ile Phe
220 225ATTACAATTA CCAAAAAAGT ATTATTTTTC TTAAAAGGTG CGCTGTGAAA TTGTGGTTTC 790CTTATTTTTT AGCGATTGTG TTCTTGCATG CATTGGGTTT 830
(2) Sequence 504 data:
(i) sequence characteristics:
(A) length: 228 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 504: met Ala Asp Lys Glu Ile Leu Ile Phe Val Glu Gly Pro Ser Asp Lys 151015 Val Phe Leu Glu Val Tyr Leu Tyr Phe Leu Glu Arg Phe Pro Ile Lys
20 25 30Asn Phe Lys Val Gln Asn Val Asp Gly Lys Asp Asn Leu Ser Lys Arg
35 40 45Leu Leu Glu Ile Glu Lys Tyr Asp Lys Thr Leu Ile Ile Phe Asp Ala
50 55 60Asp Lys Asp Tyr Glu Ser Asn Lys Lys Glu Ile Leu Lys Ile Val Ser65 70 75 80Glu Ser Lys Gln Thr lle Ser Glu Glu Gln Ile Phe Leu Phe Pro Asn
85 90 95Asn Gln Asp Asp Gly Asp Leu Glu Thr Leu Leu Leu Lys Ile Ala Asn
100 105 110His Lys Glu Phe Ile Asn Cys Phe Glu Ser Tyr Leu Asp Cys Ile Lys
115 120 125Lys Lys Glu His Tyr Lys Pro Ile Lys Asn Ile Arg Lys Ser Lys Trp
130 135 140Tyr Ala Tyr Leu Glu Ala Leu Gly Leu Glu Lys Phe Phe Gln Tyr Thr145 150 155 160Trp Asp Thr Lys Lys Lys Asn Asn Lys Lys Lys Leu Ile Ile Asp Asp
165 170 175Lys Asp Gly Asp Glu Ile Glu Ile Lys Asp Gln Tyr Lys Gly Asp Tyr
180 185 190Glu Glu Leu Lys Lys Val Leu Asp Leu Asn Ser Lys Ser Leu Ile Pro
195 200 205Leu Lys Asn Phe Leu Gly Gln Phe Ala Glu Asn Asn Gln Lys Thr Asn
210 215 220Pro Lys Ile Phe225
(2) Sequence 505 data:
(i) sequence characteristics:
(A) length: 1349bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 78...1298
(D) Other information:
(xi) Description of the sequence: sequence 505: AAGAACAAAT TGAGCCTGCT ACCGCTCTCA CTCAATGGCC GCAAAAACAA GAAAAGAAAA 60AATCATAAGG AAAAAAT ATG GCA AAA AGT ATT GAA TTG CAA GAG ATA GAA 110
Met Ala Lys Ser Ile Glu Leu Gln Glu Ile Glu
1 5 10GTG TGG GAT GGC AAT ACC GCT AGT TCT AAC GCT TTA AGA CAG GCT CAA 158Val Trp Asp Gly Asn Thr Ala Ser Ser Asn Ala Leu Arg Gln Ala Gln
15 20 25ATT GAT GTC ATC GCA GCC TAT CCT ATC ACC CCA TCA ACG CCC ATT GTG 206Ile Asp Val Ile Ala Ala Tyr Pro Ile Thr Pro Ser Thr Pro Ile Val
30 35 40CAA AAT TAT GGC TCG TTT AAG GAT AAT GGC TAT GTT GAT GGC GAA TTC 254Gln Asn Tyr Gly Ser Phe Lys Asp Asn Gly Tyr Val Asp Gly Glu Phe
45 50 55GTT TTA GTG GAA TCT GAG CAT GCC GCC ATG AGC GCA TGC GTG GGA GCT 302Val Leu Val Glu Ser Glu His Ala Ala Met Ser Ala Cys Val Gly Ala60 65 70 75GCC GCA GCT GGA GGG AGA GTC AGC ACT GCG ACT AGC TCT CAA GGT TTG 350Ala Ala Ala Gly Gly Arg Val Ser Thr Ala Thr Ser Ser Gln Gly Leu
80 85 90GCG TTA ATG GTA GAG GTT TTA TAC CAG GCT TCT GGA ATG CGT TTG CCT 398Ala Leu Met Val Glu Val Leu Tyr Gln Ala Ser Gly Met Arg Leu Pro
95 100 105ATC GTT TTG AAT TTA GTC AAT CGT GCT TTA GCA GCC CCT TTG AAT ATC 446Ile Val Leu Asn Leu Val Asn Arg Ala Leu Ala Ala Pro Leu Asn Ile
110 115 120CAT GGC GAT CAT TCT GAT ATG TAT TTA AGC AGG GAT TCT GGT TGG ATA 494His Gly Asp His Ser Asp Met Tyr Leu Ser Arg Asp Ser Gly Trp Ile
125 130 135AGT TTA TGC ACA TGC AAC CCC CAA GAA GCT TAT GAT TTC ACT TTA ATG 542Ser Leu Cys Thr Cys Asn Pro Gln Glu Ala Tyr Asp Phe Thr Leu Met140 145 150 155GCG TTT AGA ATC GCA GAG CAT CAA AAG GTG CGC GTG CCT ACT ATT GTC 590Ala Phe Arg lle Ala Glu His Gln Lys Val Arg Val Pro Thr Ile Val
160 165 170AAT CAA GAC GGG TTT TTA TGC TCG CAC ACC GTG CAA AAT GTC CGC CCT 638Asn Gln Asp Gly Phe Leu Cys Ser His Thr Val Gln Asn Val Arg Pro
175 180 185TTG AGC GAT GCA GTG GCT TAC CAA TTC GTG GGC GAA TAC CAA ACC AAG 686Leu Ser Asp Ala Val Ala Tyr Gln Phe Val Gly Glu Tyr Gln Thr Lys
190 195 200CAT TCC CTT TTG GAT TTT GAT AAA CCG GTA AGC TAT GGC GCG CAA GCT 734His Ser Leu Leu Asp Phe Asp Lys Pro Val Ser Tyr Gly Ala Gln Ala
205 210 215GAA GAA GAA TGG CAT TAT GAG CAT AAA GCC CAA CTC CAC CAT GCC ATC 782Glu Glu Glu Trp His Tyr Glu His Lys Ala Gln Leu His His Ala Ile220 225 230 235ATG AGC GCG TCT TCT GTG ATT GAA GAA GTG TTC AAT GAT TTC GCT AAA 830Met Ser Ala Ser Ser Val Ile Glu Glu Val Phe Asn Asp Phe Ala Lys
240 245 250CTC ACA GGC AGG CAA TAC CAT TTA ACC AAA ACT TTC CAG CTA GAA GAC 878Leu Thr Gly Arg Gln Tyr His Leu Thr Lys Thr Phe Gln Leu Glu Asp
255 260 265GCT GAA ATC GCT ATC TTT GCG TTA GGC ACT ACT TAT GAA TCA GCG ATC 926Ala Glu Ile Ala Ile Phe Ala Leu Gly Thr Thr Tyr Glu Ser Ala Ile
270 275 280GTA GCG GCT AAA GAA ATG CGT AAA AAA GGC ATT AAG GCC GGC GTG GCT 974Val Ala Ala Lys Glu Met Arg Lys Lys Gly Ile Lys Ala Gly Val Ala
285 290 295ACC ATC CAT TCC TTG CGC CCC TTC CCT TAT GAA AGA TTA GGG CAG GAT 1022Thr Ile His Ser Leu Arg Pro Phe Pro Tyr Glu Arg Leu Gly Gln Asp300 305 310 315TTG AAA AAT CTT AAA GCT TTA GCG ATT TTA GAC AAG AGC TCT CCA GCG 1070Leu Lys Asn Leu Lys Ala Leu Ala Ile Leu Asp Lys Ser Ser Pro Ala
320 325 330GGC ACT ATG GGG GCG ATG TTT AAT GAA GTA ACG AGC GCG GTG TAT CAA 1118Gly Thr Met Gly Ala Met Phe Asn Glu Val Thr Ser Ala Val Tyr Gln
335 340 345ACG CAA GGG ACT AAA CAC CCC GTG GTG TCT AAC TAC ATT TAT GGT TTA 1166Thr Gln Gly Thr Lys His Pro Val Val Ser Asn Tyr Ile Tyr Gly Leu
350 355 360GGC GAA AGG GAT ATG ACG ATC GCG CAT TTA TGC GAA ATT TTT GAA GAA 1214Gly Glu Arg Asp Met Thr Ile Ala His Leu Cys Glu Ile Phe Glu Glu
365 370 375ATC AAT GAA GAC GCT CTT AAA GGC ACG CTC ACG CAC CCT ACC CAA CAA 1262Ile Asn Glu Asp Ala Leu Lys Gly Thr Leu Thr His Pro Thr Gln Gln380 385 390 395TTC GTA GGC TTG CAC GGC CCT AAA ATG AGC TTT TTT TAAAAAGGAA ATATCA 1314Phe Val Gly Leu His Gly Pro Lys Met Ser Phe Phe
400 405TGGTAAAAGA AGTCAAAACA CTCAAAGGTT TTAGC 1349
(2) Sequence 506 data:
(i) sequence characteristics:
(A) length: 407 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 506: met Ala Lys Ser Ile Glu Leu Gln Glu Ile Glu Val Trp Asp Gly Asn 151015 Thr Ala Ser Ser Asn Ala Leu Arg Gln Ala Gln Ile Asp Val Ile Ala
20 25 30Ala Tyr Pro Ile Thr Pro Ser Thr Pro Ile Val Gln Asn Tyr Gly Ser
35 40 45Phe Lys Asp Asn Gly Tyr Val Asp Gly Glu Phe Val Leu Val Glu Ser
50 55 60Glu His Ala Ala Met Ser Ala Cys Val Gly Ala Ala Ala Ala Gly Gly65 70 75 80Arg Val Ser Thr Ala Thr Ser Ser Gln Gly Leu Ala Leu Met Val Glu
85 90 95Val Leu Tyr Gln Ala Ser Gly Met Arg Leu Pro Ile Val Leu Asn Leu
100 105 110Val Asn Arg Ala Leu Ala Ala Pro Leu Asn Ile His Gly Asp His Ser
115 120 125Asp Met Tyr Leu Ser Arg Asp Ser Gly Trp Ile Ser Leu Cys Thr Cys
130 135 140Asn Pro Gln Glu Ala Tyr Asp Phe Thr Leu Met Ala Phe Arg Ile Ala145 150 155 160Glu His Gln Lys Val Arg Val Pro Thr Ile Val Asn Gln Asp Gly Phe
165 170 175Leu Cys Ser His Thr Val Gln Asn Val Arg Pro Leu Ser Asp Ala Val
180185 190Ala Tyr Gln Phe Val Gly Glu Tyr Gln Thr Lys His Ser Leu Leu Asp
195 200 205Phe Asp Lys Pro Val Ser Tyr Gly Ala Gln Ala Glu Glu Glu Trp His
210 215 220Tyr Glu His Lys Ala Gln Leu His His Ala Ile Met Ser Ala Ser Ser225 230 235 240Val Ile Glu Glu Val Phe Asn Asp Phe Ala Lys Leu Thr Gly Arg Gln
245 250 255Tyr His Leu Thr Lys Thr Phe Gln Leu Glu Asp Ala Glu Ile Ala Ile
260 265 270Phe Ala Leu Gly Thr Thr Tyr Glu Ser Ala Ile Val Ala Ala Lys Glu
275 280 285Met Arg Lys Lys Gly Ile Lys Ala Gly Val Ala Thr Ile His Ser Leu
290 295 300Arg Pro Phe Pro Tyr Glu Arg Leu Gly Gln Asp Leu Lys Asn Leu Lys305 310 315 320Ala Leu Ala Ile Leu Asp Lys Ser Ser Pro Ala Gly Thr Met Gly Ala
325 330 335Met Phe Asn Glu Val Thr Ser Ala Val Tyr Gln Thr Gln Gly Thr Lys
340 345 350His Pro Val Val Ser Asn Tyr Ile Tyr Gly Leu Gly Glu Arg Asp Met
355 360 365Thr Ile Ala His Leu Cys Glu Ile Phe Glu Glu Ile Asn Glu Asp Ala
370 375 380Leu Lys Gly Thr Leu Thr His Pro Thr Gln Gln Phe Val Gly Leu His385 390 395 400Gly Pro Lys Met Ser Phe Phe
405
(2) Data in sequence 507:
(i) sequence characteristics:
(A) length: 948bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...855
(D) Other information:
(xi) Description of the sequence: and a sequence 507: AAA ATT GAA GTT TTA AGG GGT TTT TTG AAA CGA GCG TTA TAC TTA ATT 48Lys Ile Glu Val Leu Arg Gly Phe Leu Lys Arg Ala Leu Tyr Leu Ile 151015 TTA GGG CTT TTT TAC ACG CTT AAT GCA GAG AGC TTT AAA GAT GTT TTG 96Leu Gly Leu Phe Tyr Thr Leu Asn Ala Glu Ser Phe Lys Asp Val Leu
20 25 30ACT AAA GTG GAT TAC ACT TTT TTT AAT AAA AAG GTG GTT TCG CCC ATC 144Thr Lys Val Asp Tyr Thr Phe Phe Asn Lys Lys Val Val Ser Pro Ile
35 40 45AAA CGC TAT GCG GAT AGA TCG GCG TTT TAT CTG GGG CTT GGG TAT CAA 192Lys Arg Tyr Ala Asp Arg Ser Ala Phe Tyr Leu Gly Leu Gly Tyr Gln
50 55 60TTA GGG AGC ATT CAG CAC AAC TCT AGC AAC TTG AAT TTA TCC CAG CAA 240Leu Gly Ser Ile Gln His Asn Ser Ser Asn Leu Asn Leu Ser Gln Gln65 70 75 80TTC AAT AAG AGT CAG ATT ATT TTC AGC GAT AGT CTA AGC CCT GTT TTT 288Phe Asn Lys Ser Gln Ile Ile Phe Ser Asp Ser Leu Ser Pro Val Phe
85 90 95AAA AAT TCG TAT GTG TCT AAT GGC CTT GGC GTG CAA GTG GGC TAT AAG 336Lys AsnSer Tyr Val Ser Asn Gly Leu Gly Val Gln Val Gly Tyr Lys
100 105 110TGG GTG GGT AAG CAT GAA GAG ACG AAA TGG TTT GGC TTC AGG TGG GGG 384Trp Val Gly Lys His Glu Glu Thr Lys Trp Phe Gly Phe Arg Trp Gly
115 120 125CTG TTT TAT GAT TTG AGC GCC TCT CTT TAT GGC CAA AAA GAA TCA CAG 432Leu Phe Tyr Asp Leu Ser Ala Ser Leu Tyr Gly Gln Lys Glu Ser Gln
130 135 140TCT GTC ATC ATT TCC ACT TAC GGC ACT TAT ATG GAT TTA TTA TTG AAC 480Ser Val Ile Ile Ser Thr Tyr Gly Thr Tyr Met Asp Leu Leu Leu Asn145 150 155 160GCT TAT AAT GGG GAT AAG TTT TTT GCT GGG TTC AAT CTG GGG ATT GCT 528Ala Tyr Asn Gly Asp Lys Phe Phe Ala Gly Phe Asn Leu Gly Ile Ala
165 170 175TTT GCT GGA GTG TAT GAC AAA GTG AGC GAT GCG TTA TTG TAT CAA GCC 576Phe Ala Gly Val Tyr Asp Lys Val Ser Asp Ala Leu Leu Tyr Gln Ala
180 185 190CTT CTT TTA GAC ACT TTT GGC GGG AAA GTG GAT CCA AAT GGC TTC CAG 624Leu Leu Leu Asp Thr Phe Gly Gly Lys Val Asp Pro Asn Gly Phe Gln
195 200 205TTT TTG GTA AAT TTA GGG GTT CGT TTA GGG AAT AAG CAC AAC CAA TTT 672Phe Leu Val Asn Leu Gly Val Arg Leu Gly Asn Lys His Asn Gln Phe
210 215 220GGC TTT GGG ATT AAA ATC CCT ACT TAT TAT TTT AAC CAT TAT TAT TCC 720Gly Phe Gly Ile Lys Ile Pro Thr Tyr Tyr Phe Asn His Tyr Tyr Ser225 230 235 240ATG AAT AAC ATT AGC AAT AAT AGT GAA GAT GTC CTC AAA GTT TTA CGA 768Met Asn Asn Ile Ser Asn Asn Ser Glu Asp Val Leu Lys Val Leu Arg
245 250 255TTT TTA GAA TAC GGG ATC AAC AGC TTG TTA TAC CAA GTT GAT TTC AGG 816Phe Leu Glu Tyr Gly Ile Asn Ser Leu Leu Tyr Gln Val Asp Phe Arg
260 265 270CGC AAT TAC TCG GTT TAT TTC AAC TAC ACT TAT ATT TTT TAAGCGATAG CG 867Arg Asn Tyr Ser Val Tyr Phe Asn Tyr Thr Tyr Ile Phe
275 280 285TTTAAAGCGT TCTTAATTGA GCGATTTCGT CTCTCAAACG CATCGCTTCT TCAAAATCCA 927AATTCTTCGT GCATTCTCGC A 948
(2) Sequence 508 data:
(i) sequence characteristics:
(A) length: 285 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 508: lys Ile Glu Val Leu Arg Gly Phe Leu Lys Arg Ala Leu Tyr Leu Ile 151015 Leu Gly Leu Phe Tyr Thr Leu Asn Ala Glu Ser Phe Lys Asp Val Leu
20 25 30Thr Lys Val Asp Tyr Thr Phe Phe Asn Lys Lys Val Val Ser Pro Ile
35 40 45Lys Arg Tyr Ala Asp Arg Ser Ala Phe Tyr Leu Gly Leu Gly Tyr Gln
50 55 60Leu Gly Ser Ile Gln His Asn Ser Ser Asn Leu Asn Leu Ser Gln Gln65 70 75 80Phe Asn Lys Ser Gln Ile Ile Phe Ser Asp Ser Leu Ser Pro Val Phe
85 9095Lys Asn Ser Tyr Val Ser Asn Gly Leu Gly Val Gln Val Gly Tyr Lys
100 105 110Trp Val Gly Lys His Glu Glu Thr Lys Trp Phe Gly Phe Arg Trp Gly
115 120 125Leu Phe Tyr Asp Leu Ser Ala Ser Leu Tyr Gly Gln Lys Glu Ser Gln
130 135 140Ser Val Ile Ile Ser Thr Tyr Gly Thr Tyr Met Asp Leu Leu Leu Asn145 150 155 160Ala Tyr Asn Gly Asp Lys Phe Phe Ala Gly Phe Asn Leu Gly Ile Ala
165 170 175Phe Ala Gly Val Tyr Asp Lys Val Ser Asp Ala Leu Leu Tyr Gln Ala
180 185 190Leu Leu Leu Asp Thr Phe Gly Gly Lys Val Asp Pro Asn Gly Phe Gln
195 200 205Phe Leu Val Asn Leu Gly Val Arg Leu Gly Asn Lys His Asn Gln Phe
210 215 220Gly Phe Gly Ile Lys Ile Pro Thr Tyr Tyr Phe Asn His Tyr Tyr Ser225 230 235 240Met Asn Asn Ile Ser Asn Asn Ser Glu Asp Val Leu Lys Val Leu Arg
245 250 255Phe Leu Glu Tyr Gly Ile Asn Ser Leu Leu Tyr Gln Val Asp Phe Arg
260 265 270Arg Asn Tyr Ser Val Tyr Phe Asn Tyr Thr Tyr Ile Phe
275 280 285
(2) Sequence 509 data:
(i) sequence characteristics:
(A) length: 1840bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 35...1735
(D) Other information:
(xi) Description of the sequence: sequence 509: AAATTTTAAG CGTAACTGAT TGAAAGGAAA ACAG ATG AGA CGG AGT TTT TTG AAA 55
Met Arg Arg Ser Phe Leu Lys
1 5ACG ATT GGC TTG GGT GTG ATA GCA GTC TTT TTG GGT TTG TTA AAC CCT 103Thr Ile Gly Leu Gly Val Ile Ala Leu Phe Leu Gly Leu Leu Asn Pro
10 15 20TTG AGT GCG GCG AGT TAC CCC CCC ATT AAA AAC ACT AAA GTA GGC TTA 151Leu Ser Ala Ala Ser Tyr Pro Pro Ile Lys Asn Thr Lys Val Gly Leu
25 30 35GCC CTT TCT AGC CAC CCG CTA GCT AGT GAG ATC GGG CAA AAG GTT TTA 199Ala Leu Ser Ser His Pro Leu Ala Ser Glu Ile Gly Gln Lys Val Leu40 45 50 55GAA GAG GGA GGT AAT GCG ATT GAT GCG GCT GTA GCG ATA GGT TTT GCT 247Glu Glu Gly Gly Asn Ala Ile Asp Ala Ala Val Ala Ile Gly Phe Ala
60 65 70CTT GCG GTT GTC CAT CCG GCA GCA GGC AAT ATT GGT GGA GGC GGT TTT 295Leu Ala Val Val His Pro Ala Ala Gly Asn Ile Gly Gly Gly Gly Phe
75 80 85GCG GTT ATC CAT TTG GCT AAT GGT GAA AAT GTT GCG TTA GAT TTT AGA 343Ala Val Ile His Leu Ala Asn Gly Glu Asn Val Ala Leu Asp Phe Arg
90 95 100GAA AAA GCC CCC TTA AAA GCC ACT AAA AAC ATG TTT TTA GAC AAG CAA 391Glu Lys Ala Pro Leu Lys Ala Thr Lys Asn Met Phe Leu Asp Lys Gln
105 110 115GGC AAT GTA GTC CCT AAA CTC AGC GAA GAT GGC TAT TTG GCG GCC GGG 439Gly Asn Val Val Pro Lys Leu Ser Glu Asp Gly Tyr Leu Ala Ala Gly120 125 130 135GTT CCT GGA ACG GTG GCA GGC ATG GAA GCG ATG CTG AAA AAA TAC GGC 487Val Pro Gly Thr Val Ala Gly Met Glu Ala Met Leu Lys Lys Tyr Gly
140 145 150ACT AAA AAA CTA TCG CAA CTC ATT GAT CCT GCC ATT AAA TTG GCT GAA 535Thr Lys Lys Leu Ser Gln Leu Ile Asp Pro Ala Ile Lys Leu Ala Glu
155 160 165AAT GGT TAT GCG ATT TCA CAA AGA CAA GCA GAA ACC CTA AAG GAA GCA 583Asn Gly Tyr Ala Ile Ser Gln Arg Gln Ala Glu Thr Leu Lys Glu Ala
170 175 180AGG GAG CGG TTT TTA AAA TAC AGT TCT AGC AAA AAG TAT TTT TTT AAA 631Arg Glu Arg Phe Leu Lys Tyr Ser Ser Ser Lys Lys Tyr Phe Phe Lys
185 190 195AAA GGC CAT CTT GAT TAT CAA GAA GGG GAT TTG TTT GTC CAA AAA GAT 679Lys Gly His Leu Asp Tyr Gln Glu Gly Asp Leu Phe Val Gln Lys Asp200 205 210 215TTA GCC AAG ACT TTG AAT CAA ATC AAA ACG CTA GGC GCT AAA GGC TTT 727Leu Ala Lys Thr Leu Asn Gln Ile Lys Thr Leu Gly Ala Lys Gly Phe
220 225 230TAT CAA GGG CAA GTC GCT GAG CTT ATT GAG AAA GAC ATG AAA AAA AAT 775Tyr Gln Gly Gln Val Ala Glu Leu Ile Glu Lys Asp Met Lys Lys Asn
235 240 245GGA GGG ATT ATC ACT AAA GAA GAT TTA GCC AGT TAC AAT GTG AAA TGG 823Gly Gly Ile Ile Thr Lys Glu Asp Leu Ala Ser Tyr Asn Val Lys Trp
250 255 260CGC AAA CCC GTG GTA GGG AGT TAT CGT GGG TAT AAG ATC ATT TCT ATG 871Arg Lys Pro Val Val Gly Ser Tyr Arg Gly Tyr Lys Ile Ile Ser Met
265 270 275TCG CCG CCA AGT TCG GGA GGC ACG CAT TTG ATC CAG ATT TTA AAT GTC 919Ser Pro Pro Ser Ser Gly Gly Thr His Leu Ile Gln Ile Leu Asn Val280 285 290 295ATG GAA AAT GCG GAT TTA AGC GCC CTT GGG TAT GGG GCT TCT AAG AAT 967Met Glu Asn Ala Asp Leu Ser Ala Leu Gly Tyr Gly Ala Ser Lys Asn
300 305 310ATC CAT ATC GCT GCC GAA GCG ATG CGT CAG GCT TAT GCG GAT AGA TCG 1015Ile His Ile Ala Ala Glu Ala Met Arg Gln Ala Tyr Ala Asp Arg Ser
315 320 325GTT TAT ATG GGA GAC GCT GAT TTT GTT TCG GTG CCG GTG GAT AAA TTG 1063Val Tyr Met Gly Asp Ala Asp Phe Val Ser Val Pro Val Asp Lys Leu
330 335 340ATT AAT AAA GCG TAT GCC AAA AAG ATT TTT GAC ACT ATC CAG CCA GAT 1111Ile Asn Lys Ala Tyr Ala Lys Lys Ile Phe Asp Thr Ile Gln Pro Asp
345 350 355ACG GTT ACG CCA AGC TCT CAA ATC AAA CCA GGA ATG GGG CAG TTG CAT 1159Thr Val Thr Pro Ser Ser Gln Ile Lys Pro Gly Met Gly Gln Leu His360 365 370 375GAG GGG AGC AAT ACC ACG CAT TAT TCT GTA GCG GAC AGG TGG GGG AAT 1207Glu Gly Ser Asn Thr Thr His Tyr Ser Val Ala Asp Arg Trp Gly Asn
380 385 390GCA GTC AGC GTT ACT TAC ACC ATT AAC GCT TCT TAT GGA AGC GCT GCC 1255Ala Val Ser Val Thr Tyr Thr Ile Asn Ala Ser TyrGly Ser Ala Ala
395 400 405AGT ATT GAT GGG GCA GGA TTT TTA TTG AAC AAT GAA ATG GAT GAT TTT 1303Ser Ile Asp Gly Ala Gly Phe Leu Leu Asn Asn Glu Met Asp Asp Phe
410 415 420TCC ATC AAG CCA GGG AAT CCC AAT CTC TAT GGT TTA GTA GGG GGC GAT 1351Ser Ile Lys Pro Gly Asn Pro Asn Leu Tyr Gly Leu Val Gly Gly Asp
425 430 435GCG AAT GCG ATT GAA GCC AAT AAG CGC CCT TTA AGC TCC ATG TCG CCT 1399Ala Asn Ala Ile Glu Ala Asn Lys Arg Pro Leu Ser Ser Met Ser Pro440 445 450 455ACG ATT GTG TTG AAA AAC AAT AAG GTT TTT TTG GTG GTG GGA AGC CCT 1447Thr Ile Val Leu Lys Asn Asn Lys Val Phe Leu Val Val Gly Ser Pro
460 465 470GGA GGG TCT AGG ATT ATC ACT ACG GTG CTG CAA GTG ATT TCT AAT GTC 1495Gly Gly Ser Arg Ile Ile Thr Thr Val Leu Gln Val Ile Ser Asn Val
475 480 485ATT GAT TAT AAT ATG AAT ATT TCT GAA GCG GTT TCA GCC CCA AGA TTT 1543Ile Asp Tyr Asn Met Asn Ile Ser Glu Ala Val Ser Ala Pro Arg Phe
490 495 500CAC ATG CAA TGG CTC CCT GAT GAA TTA AGG ATT GAA AAG TTT GGC ATG 1591His Met Gln Trp Leu Pro Asp Glu Leu Arg Ile Glu Lys Phe Gly Met
505 510 515CCC GCT GAT GTG AAA GAC AAC CTC ACT AAA ATG GGC TAT CAA ATC GTT 1639Pro Ala Asp Val Lys Asp Asn Leu Thr Lys Met Gly Tyr Gln Ile Val520 525 530 535 ACT AAG CCG GTC ATG GGT GAT GTG AAT GCG ATC CAA GTT TTG CCT AAA 1687Thr Lys Pro Val Met Gly Asp Val Asn Ala Ile Gln Val Leu Pro Lys
540545 550ACT AAA GGG AGC GTT TTC TAT GGT TCA ACG GAT CCA AGG AAA GAA TTT T 1736Thr Lys Gly Ser Val Phe Tyr Gly Ser Thr Asp Pro Arg Lys Glu Phe
555 560 565AATTCTTTGT CATATACAGG TTTTTAATCC TATTTAGCCT TATTTTTTGG GATGGAGGGG 1796GGCTTTTTAG CGAGAAAATC TTAAATTTAG TTTTAAAATT CATA 1840
(2) Sequence 510 data:
(i) sequence characteristics:
(A) length: 567 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 510: met Arg Arg Ser Phe Leu Lys Thr Ile Gly Leu Gly Val Ile Ala Leu 151015 Phe Leu Gly Leu Leu Asn Pro Leu Ser Ala Ala Ser Tyr Pro Pro Ile
20 25 30Lys Asn Thr Lys Val Gly Leu Ala Leu Ser Ser His Pro Leu Ala Ser
35 40 45Glu Ile Gly Gln Lys Val Leu Glu Glu Gly Gly Asn Ala Ile Asp Ala
50 55 60Ala Val Ala Ile Gly Phe Ala Leu Ala Val Val His Pro Ala Ala Gly65 70 75 80Asn Ile Gly Gly Gly Gly Phe Ala Val Ile His Leu Ala Asn Gly Glu
85 90 95Asn Val Ala Leu Asp Phe Arg Glu Lys Ala Pro Leu Lys Ala Thr Lys
100 105 110Asn Met Phe Leu Asp Lys Gln Gly Asn Val Val Pro Lys Leu Ser Glu
115 120 125Asp Gly Tyr Leu Ala Ala Gly Val Pro Gly Thr Val Ala Gly Met Glu
130 135 140Ala Met Leu Lys Lys Tyr Gly Thr Lys Lys Leu Ser Gln Leu Ile Asp145 150 155 160Pro Ala Ile Lys Leu Ala Glu Asn Gly Tyr Ala Ile Ser Gln Arg Gln
165 170 175Ala Glu Thr Leu Lys Glu Ala Arg Glu Arg Phe Leu Lys Tyr Ser Ser
180 185 190Ser Lys Lys Tyr Phe Phe Lys Lys Gly His Leu Asp Tyr Gln Glu Gly
195 200 205Asp Leu Phe Val Gln Lys Asp Leu Ala Lys Thr Leu Asn Gln Ile Lys
210 215 220Thr Leu Gly Ala Lys Gly Phe Tyr Gln Gly Gln Val Ala Glu Leu Ile225 230 235 240Glu Lys Asp Met Lys Lys Asn Gly Gly Ile Ile Thr Lys Glu Asp Leu
245 250 255Ala Ser Tyr Asn Val Lys Trp Arg Lys Pro Val Val Gly Ser Tyr Arg
260 265 270Gly Tyr Lys Ile Ile Ser Met Ser Pro Pro Ser Ser Gly Gly Thr His
275 280 285Leu Ile Gln Ile Leu Asn Val Met Glu Asn Ala Asp Leu Ser Ala Leu
290 295 300Gly Tyr Gly Ala Ser Lys Asn Ile His Ile Ala Ala Glu Ala Met Arg305 310 315 320Gln Ala Tyr Ala Asp Arg Ser Val Tyr Met Gly Asp Ala Asp Phe Val
325 330 335Ser Val Pro Val Asp Lys Leu Ile Asn Lys Ala Tyr Ala Lys Lys Ile
340 345 350Phe Asp Thr Ile Gln Pro Asp Thr Val Thr Pro Ser Ser Gln Ils Lys
355 360 365Pro Gly Met Gly Gln Leu His Glu Gly Ser Asn Thr Thr His Tyr Ser
370 375 380Val Ala Asp Arg Trp Gly Asn Ala Val Ser Val Thr Tyr Thr Ile Asn385 390 395 400Ala Ser Tyr Gly Ser Ala Ala Ser Ile Asp Gly Ala Gly Phe Leu Leu
405 410 415Asn Asn Glu Met Asp Asp Phe Ser Ile Lys Pro Gly Asn Pro Asn Leu
420 425 430Tyr Gly Leu Val Gly Gly Asp Ala Asn Ala Ile Glu Ala Asn Lys Arg
435 440 445Pro Leu Ser Ser Met Ser Pro Thr Ile Val Leu Lys Asn Asn Lys Val
450 455 460Phe Leu Val Val Gly Ser Pro Gly Gly Ser Arg Ile Ile Thr Thr Val465 470 475 480Leu Gln Val Ile Ser Asn Val Ile Asp Tyr Asn Met Asn Ile Ser Glu
485 490 495Ala Val Ser Ala Pro Arg Phe His Met Gln Trp Leu Pro Asp Glu Leu
500 505 510Arg Ile Glu Lys Phe Gly Met Pro Ala Asp Val Lys Asp Asn Leu Thr
515 520 525Lys Met Gly Tyr Gln Ile Val Thr Lys Pro Val Met Gly Asp Val Asn
530 535 540Ala Ile Gln Val Leu Pro Lys Thr Lys Gly Ser Val Phe Tyr Gly Ser545 550 555 560Thr Asp Pro Arg Lys Glu Phe
565
(2) Sequence 511 data:
(i) sequence characteristics:
(A) length: 719bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 76...630
(D) Other information:
(xi) Description of the sequence: sequence 511: TGCAACACTT GTATCCTTCA AGCGAACAAG CTAAAATGGC GCAAAAAATC TTAGAAAACA 60AGGAGAAACA CCACC ATG CAA AAC CAT GAT TTA GAG TCA ATC AAA CAA GCC 111
Met Gln Asn His Asp Leu Glu Ser Ile Lys Gln Ala
1 5 10GCT TTG ATT GAA TAT GAA GTG AGA GAA CAA GGC TCT AGT ATT GTG CTA 159Ala Leu Ile Glu Tyr Glu Val Arg Glu Gln Gly Ser Ser Ile Val Leu
15 20 25GAC AGC AAT ATT TCC AAA GAG CCT TTA GAG TTT ATT ATA GGC ACT AAT 207Asp Ser Asn Ile Ser Lys Glu Pro Leu Glu Phe Ile Ile Gly Thr Asn
30 35 40CAA ATC ATA GCA GGG TTA GAA AAG GCG GTA TTA AAG GCT CAA ATT GGC 255Gln Ile Ile Ala Gly Leu Glu Lys Ala Val Leu Lys Ala Gln Ile Gly45 50 55 60GAG TGG GAA GAG GTT GTC ATC GCC CCA GAG GAA GCT TAT GGG GTT TAT 303Glu Trp Glu Glu Val Val Ile Ala Pro Glu Glu Ala Tyr Gly Val Tyr
65 70 75GAA AGC AGC TAT TTG CAA GAA GTC CCT AGA GAT CAA TTT GAA GGC ATT 351Glu Ser Ser Tyr Leu Gln Glu Val Pro Arg Asp Gln Phe Glu Gly Ile
80 85 90GAA TTA GAA AAA GGC ATG AGC GTT TTT GGG CAA ACT GAA GAC AAT CAA 399Glu Leu Glu Lys Gly Met Ser Val Phe Gly Gln Thr Glu Asp Asn Gln
95 100 105ACC ATT CAA GCC ATT ATC AAA GAC TTT AGC GCT ACG CAT GTG ATG GTG 447Thr Ile Gln Ala Ile Ile Lys Asp Phe Ser Ala Thr His Val Met Val
110 115 120GAT TAT AAC CAC CCG TTA GCC GGG AAA ACT TTA GCG TTT CGT TTC AAG 495Asp Tyr Asn His Pro Leu Ala Gly Lys Thr Leu Ala Phe Arg Phe Lys125 130 135 140GTT TTA GGT TTT AGG GAA GTG AGC GAA GAA GAA ATT TTA GCT TCA CAC 543Val Leu Gly Phe Arg Glu Val Ser Glu Glu Glu Ile Leu Ala Ser His
145 150 155CAT GGC GGT GGG ACA GGT TGC TGT GGC GGT CAT GGG GGT CAT GGC GGA 591His Gly Gly Gly Thr Gly Cys Cys Gly Gly His Gly Gly His Gly Gly
160 165 170AAG AAA GGT GGG GGT TGT GGT TGC TCA TGT TCG CAT GGG TAGTAAGGTA TA 642Lys Lys Gly Gly Gly Cys Gly Cys Ser Cys Ser His Gly
175 180 185GGAGTATTTA AAAGGCAAGG TCATGAATAG TTCTAATCTC AAAAATTGGC TATTCCCTAC 702CATTTGCTTT TTTTTAT 719
(2) Sequence 512 data:
(i) sequence characteristics:
(A) length: 185 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 512: met Gln Asn His Asp Leu Glu Ser Ile Lys Gln Ala Ala Leu Ile Glu 151015 Tyr Glu Val Arg Glu Gln Gly Ser Ser Ile Val Leu Asp Ser Asn Ile
20 25 30Ser Lys Glu Pro Leu Glu Phe Ile Ile Gly Thr Asn Gln Ile Ile Ala
35 40 45Gly Leu Glu Lys Ala Val Leu Lys Ala Gln Ile Gly Glu Trp Glu Glu
50 55 60Val Val Ile Ala Pro Glu Glu Ala Tyr Gly Val Tyr Glu Ser Ser Tyr65 70 75 80Leu Gln Glu Val Pro Arg Asp Gln Phe Glu Gly Ile Glu Leu Glu Lys
85 90 95Gly Met Ser Val Phe Gly Gln Thr Glu Asp Asn Gln Thr Ile Gln Ala
100 105 110Ile Ile Lys Asp Phe Ser Ala Thr His Val Met Val Asp Tyr Asn His
115 120 125Pro Leu Ala Gly Lys Thr Leu Ala Phe Arg Phe Lys Val Leu Gly Phe
130 135 140Arg Glu Val Ser Glu Glu Glu Ile Leu Ala Ser His His Gly Gly Gly145 150 155 160Thr Gly Cys Cys Gly Gly His Gly Gly His Gly Gly Lys Lys Gly Gly
165 170 175Gly Cys Gly Cys Ser Cys Ser His Gly
180 185
(2) Sequence 513 data:
(i) sequence characteristics:
(A) length: 339bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...336
(D) Other information:
(xi) Description of the sequence: sequence 513: ATC TCT TCT AAG CGT TTG GAG ATT TCA AGA CTT TTG GAG CGT AAA AAT 48Ile Ser Ser Lys Arg Leu Glu Ile Ser Arg Leu Leu Glu Arg Lys Asn 151015 GAA CGC AGT TTT TTA GCC GAA AAA TAC CAC AAA ATC CCC ACA AAT AAA 96Glu Arg Ser Phe Leu Ala Glu Lys Tyr His Lys Ile Pro Thr Asn Lys
20 25 30AGG AAA TTT AAA GAA CGC TCT ATA ATA TCT GTT TGT GAA ATA TCC AAT 144Arg Lys Phe Lys Glu Arg Ser Ile Ile Ser Val Cys Glu Ile Ser Asn
35 40 45CCA GTA GCG CAC AAA GGG CTT AAA AGG ATC AAA AAC CCT AAC ACC ATT 192Pro Val Ala His Lys Gly Leu Lys Arg Ile Lys Asn Pro Asn Thr Ile
50 55 60TTA ACT ACA AAC ATT CAT CAA CTC CCT AAA CCC ATA GCC ACA CGC TTG 240Leu Thr Thr Asn Ile His Gln Leu Pro Lys Pro Ile Ala Thr Arg Leu65 70 75 80TTT AAC TCG TCT TCA AAT ACC GGC ATT TGC GCT TGC AAC TGC TCT TTT 288Phe Asn Ser Ser Ser Asn Thr Gly Ile Cys Ala Cys Asn Cys Ser Phe
85 90 95AGC GCT TGC TTT TCA TTT TGT AAT TGC TTC GCA AAC GCT TCA AAC TCT T 337Ser Ala Cys Phe Ser Phe Cys Asn Cys Phe Ala Asn Ala Ser Asn Ser
100 105 110GA339
(2) Sequence 514 data:
(i) sequence characteristics:
(A) length: 112 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 514: ile Ser Ser Lys Arg Leu Glu Ile Ser Arg Leu Leu Glu Arg Lys Asn 151015 Glu Arg Ser Phe Leu Ala Glu Lys Tyr His Lys Ile Pro Thr Asn Lys
20 25 30Arg Lys Phe Lys Glu Arg Ser Ile Ile Ser Val Cys Glu Ile Ser Asn
35 40 45Pro Val Ala His Lys Gly Leu Lys Arg Ile Lys Asn Pro Asn Thr Ile
50 55 60Leu Thr Thr Asn Ile His Gln Leu Pro Lys Pro Ile Ala Thr Arg Leu65 70 75 80Phe Asn Ser Ser Ser Asn Thr Gly Ile Cys Ala Cys Asn Cys Ser Phe
85 90 95Ser Ala Cys Phe Ser Phe Cys Asn Cys Phe Ala Asn Ala Ser Asn Ser
100 105 110
(2) Data for sequence 515:
(i) sequence characteristics:
(A) length: 1440bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 34...1338
(D) Other information:
(xi) Description of the sequence: sequence 515: TAATCTATAC CAAATAGTAA GGAGTTATCT AAC ATG GGG TTT TTC AAG CTT AAA 54
Met Gly Phe Phe Lys Leu Lys
1 5GAA CAC AAC ACT AAC ATT GCC ACC GAG TTT AGA GCG GGT TTA ACG ACC 102Glu His Asn Thr Asn Ile Ala Thr Glu Phe Arg Ala Gly Leu Thr Thr
10 15 20TTT ATC ACC ATG ATT TAC ATC GTG CCC TTA AAC GCT CTT ATC CTT TCT 150Phe Ile Thr Met Ile Tyr Ile Val Pro Leu Asn Ala Leu Ile Leu Ser
25 30 35CAA GCC AAC ATG CCT TAT GAA GCC CTT TTA AGT GCA ACG GCC ATT ATC 198Gln Ala Asn Met Pro Tyr Glu Ala Leu Leu Ser Ala Thr Ala Ile Ile40 45 50 55ACT ATC TTA TCG AGC GTG TTT AAC GGA TTG TGG GCA AAC ACC CCT ATC 246Thr Ile Leu Ser Ser Val Phe Asn Gly Leu Trp Ala Asn Thr Pro Ile
60 65 70GCT ATG AGC GTG GGC TTA GGG CTG TCA GCT TAT TTT AGC TTC GGG TTG 294Ala Met Ser Val Gly Leu Gly Leu Ser Ala Tyr Phe Ser Phe Gly Leu
75 80 85GTT CAA GGG TTA AAA CTC CCT TGG CAG AGC GCT TTA GGC ATC GTA GCG 342Val Gln Gly Leu Lys Leu Pro Trp Gln Ser Ala Leu Gly Ile Val Ala
90 95 100CTC TCG GGA GCG ATT TTT GTG ATT TTG TCT TTC ACT AAA TTT AGA AGT 390Leu Ser Gly Ala Ile Phe Val Ile Leu Ser Phe Thr Lys Phe Arg Ser
105 110 115TGG GTC ATG CGA AGC ATT CCT AGC GAT TTA AGG CGT GCG GTG AGT GCG 438Trp Val Met Arg Ser Ile Pro Ser Asp Leu Arg Arg Ala Val Ser Ala120 125 130 135GGG ATA GGG GCT TTT ATC GCG TTT ATT GGC CTT AAA GAA ATG CAT ATC 486Gly Ile Gly Ala Phe Ile Ala Phe Ile Gly Leu Lys Glu Met His Ile
140 145 150GTC GTT ACC CAT AAR GCT ACG CTT GTA ACC TTA GGC GAT TTT GGC GAT 534Val Val Thr His Xaa Ala Thr Leu Val Thr Leu Gly Asp Phe Gly Asp
155 160 165CCG CAT GTG TTA TTG GGG GTT GTG GGG ATC ATT CTA ACT TTC GCG CTC 582Pro His Val Leu Leu Gly Val Val Gly Ile Ile Leu Thr Phe Ala Leu
170 175 180TAC ACG CTC AAA ATC AGG GGT TCT TTC ATT ATA GCG GTC TTA ATC ACT 630Tyr Thr Leu Lys Ile Arg Gly Ser Phe Ile Ile Ala Val Leu Ile Thr
185 190 195TCC ATT CTC GCA TGG GTT TTA AAG CTA GCC CCT TAC CCT AGC GAG TTT 678Ser Ile Leu Ala Trp Val Leu Lys Leu Ala Pro Tyr Pro Ser Glu Phe200 205 210 215TTT TCC ATG CCC GCT AGC ATT GGC CCT ATC GCC TTT CAA TTA GAC TTT 726Phe Ser Met Pro Ala Ser Ile Gly Pro Ile Ala Phe Gln Leu Asp Phe
220 225 230AAG GGC ATT TTT TTT GAT GCG AGT GGG GCT TTC ACT TTA GCG TTA GTG 774Lys Gly Ile Phe Phe Asp Ala Ser Gly Ala Phe Thr Leu Ala Leu Val
235 240 245CCA GTT ATT ATC ACT TTT TTT GTA ACC GAT TTG TTT GAT TCT TTA GGC 822Pro Val Ile Ile Thr Phe Phe Val Thr Asp Leu Phe Asp Ser Leu Gly
250255 260ACG CTT GCA GGG ATT GGC CAC AAG ACT GAT TTT TTC AAT GAT GAA GAA 870Thr Leu Ala Gly Ile Gly His Lys Thr Asp Phe Phe Asn Asp Glu Glu
265 270 275AAA AAC AAG GAA TTG GAA AAG ACT TTG GAA GCG GAT GCG GTG GCT TCT 918Lys Asn Lys Glu Leu Glu Lys Thr Leu Glu Ala Asp Ala Val Ala Ser280 285 290 295TTA GGG AGC GCG GTG GTG GGC GTT TCT ACT ACG ACC GCT TTT ATA GAG 966Leu Gly Ser Ala Val Val Gly Val Ser Thr Thr Thr Ala Phe Ile Glu
300 305 310AGC GCG AGT GGG GTT GAA GAG GGG GGC CGC ACA GGG CTT ACA GCG GTT 1014Ser Ala Ser Gly Val Glu Glu Gly Gly Arg Thr Gly Leu Thr Ala Val
315 320 325TTT ACC GGA TTA TTT TTT GTT TTA ACG CTC TTT TGC TTG CCT CTT TTA 1062Phe Thr Gly Leu Phe Phe Val Leu Thr Leu Phe Cys Leu Pro Leu Leu
330 335 340AAA GCT ATT CCT AGC AAT GCG ATT TAT CCG GTG CTG GTG GTA GTA GGG 1110Lys Ala Ile Pro Ser Asn Ala Ile Tyr Pro Val Leu Val Val Val Gly
345 350 355GTT TTG ATG TTT AGC GTG TTA GAG GGG GTG AAT TTT AAA GAC ATG GCC 1158Val Leu Met Phe Ser Val Leu Glu Gly Val Asn Phe Lys Asp Met Ala360 365 370 375ATT AGC GTT TCC ACT TTT TTA ACC GTG GTG ATG ATG CCC TTA ACC TTC 1206Ile Ser Val Ser Thr Phe Leu Thr Val Val Met Met Pro Leu Thr Phe
380 385 390TCC ATT GCC GAT GGC TTA GCC TTT GGC TTT TTG TCT TAT AGT ATC ATC 1254Ser Ile Ala Asp Gly Leu Ala Phe Gly Phe Leu Ser Tyr Ser Ile Ile
395 400 405AAA TTG GTT CAA AAA GAC TTC AAA GCA CTC AAT TCAGGC ATT ATC ATT 1302Lys Leu Val Gln Lys Asp Phe Lys Ala Leu Asn Ser Gly Ile Ile Ile
410 415 420CTC TGC ATC ATT TCT GTT TCT GTA TTT ATC TTT CGT TAAGCTCTTT TTAAGG 1354Leu Cys Ile Ile Ser Val Ser ValPhe Ile Phe Arg
425 430 435GGCTTTGCAT TTTTTACTCA TTTCATGCCT CTTTTTCTTT ATTTAGACAG ATTATTATCT 1414TAAAATAATT GTAATATCAT TATTAT 1440
(2) Sequence 516 data:
(i) sequence characteristics:
(A) length: 435 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 516: met Gly Phe Phe Lys Leu Lys Glu His Asn Thr Asn Ile Ala Thr Glu 151015 Phe Arg Ala Gly Leu Thr Thr Phe Ile Thr Met Ile Tyr Ile Val Pro
20 25 30Leu Asn Ala Leu Ile Leu Ser Gln Ala Asn Met Pro Tyr Glu Ala Leu
35 40 45Leu Ser Ala Thr Ala Ile Ile Thr Ile Leu Ser Ser Val Phe Asn Gly
50 55 60Leu Trp Ala Asn Thr Pro Ile Ala Met Ser Val Gly Leu Gly Leu Ser65 70 75 80Ala Tyr Phe Ser Phe Gly Leu Val Gln Gly Leu Lys Leu Pro Trp Gln
85 90 95Ser Ala Leu Gly Ile Val Ala Leu Ser Gly Ala Ile Phe Val Ile Leu
100105 110Ser Phe Thr Lys Phe Arg Ser Trp Val Met Arg Ser Ile Pro Ser Asp
115 120 125Leu Arg Arg Ala Val Ser Ala Gly Ile Gly Ala Phe Ile Ala Phe Ile
130 135 140Gly Leu Lys Glu Met His Ile Val Val Thr His Xaa Ala Thr Leu Val145 150 155 160Thr Leu Gly Asp Phe Gly Asp Pro His Val Leu Leu Gly Val Val Gly
165 170 175Ile Ile Leu Thr Phe Ala Leu Tyr Thr Leu Lys Ile Arg Gly Ser Phe
180 185 190Ile Ile Ala Val Leu Ile Thr Ser Ile Leu Ala Trp Val Leu Lys Leu
195 200 205Ala Pro Tyr Pro Ser Glu Phe Phe Ser Met Pro Ala Ser Ile Gly Pro
210 215 220Ile Ala Phe Gln Leu Asp Phe Lys Gly Ile Phe Phe Asp Ala Ser Gly225 230 235 240Ala Phe Thr Leu Ala Leu Val Pro Val Ile Ile Thr Phe Phe Val Thr
245 250 255Asp Leu Phe Asp Ser Leu Gly Thr Leu Ala Gly Ile Gly His Lys Thr
260 265 270Asp Phe Phe Asn Asp Glu Glu Lys Asn Lys Glu Leu Glu Lys Thr Leu
275 280 285Glu Ala Asp Ala Val Ala Ser Leu Gly Ser Ala Val Val Gly Val Ser
290 295 300Thr Thr Thr Ala Phe Ile Glu Ser Ala Ser Gly Val Glu Glu Gly Gly305 310 315 320Arg Thr Gly Leu Thr Ala Val Phe Thr Gly Leu Phe Phe Val Leu Thr
325 330 335Leu Phe Cys Leu Pro Leu Leu Lys Ala Ile Pro Ser Asn Ala Ile Tyr
340 345 350Pro Val Leu Val Val Val Gly Val Leu Met Phe Ser Val Leu Glu Gly
355 360 365Val Asn Phe Lys Asp Met Ala lle Ser Val Ser Thr Phe Leu Thr Val
370 375 380Val Met Met Pro Leu Thr Phe Ser Ile Ala Asp Gly Leu Ala Phe Gly385 390 395 400Phe Leu Ser Tyr Ser Ile Ile Lys Leu Val Gln Lys Asp Phe Lys Ala
405 410 415Leu Asn Ser Gly Ile Ile Ile Leu Cys Ile Ile Ser Val Ser Val Phe
420 425 430Ile Phe Arg
435
(2) Data in sequence 517:
(i) sequence characteristics:
(A) length: 843bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 66...764
(D) Other information:
(xi) Description of the sequence: sequence 517: GCTCACTTTT TGGGATTAAG CCCCCTAGAT TATGGCAAAA ACTTATTAAA CTTTAAAGGA 60CAACC ATG ACC CCT CAC ATC AAC GCC AAA ATC GGC GAT TTT TAT CCT CAA 110
Met Thr Pro His Ile Asn Ala Lys Ile Gly Asp Phe Tyr Pro Gln
1 5 10 15TGC CTT TTA TGC GGC GAT CCC TTA AGG GTG AGC TAC ATT GCA AAA AAA 158Cys Leu Leu Cys Gly Asp Pro Leu Arg Val Ser Tyr Ile Ala Lys Lys
20 25 30TTC TTA CAA GAC GCC AAA GAG ATC ACG AAT GTG CGT AAC ATG CTA GGC 206Phe Leu Gln Asp Ala Lys Glu Ile Thr Asn Val Arg Asn Met Leu Gly
35 40 45TTT AGC GGG AAG TAT AAG GGT AGG GGG ATT TCT TTA ATG GGG CAT GGC 254Phe Ser Gly Lys Tyr Lys Gly Arg Gly Ile Ser Leu Met Gly His Gly
50 55 60ATG GGC ATT GCG TCA TGC ACG ATT TAT GTA ACC GAA CTC ATT AAA ACC 302Met Gly Ile Ala Ser Cys Thr Ile Tyr Val Thr Glu Leu Ile Lys Thr
65 70 5TAT CAG GTT AAA GAG CTT TTA AGG ATT GGC ACT TGC GGG GCG ATT AGC 350Tyr Gln Val Lys Glu Leu Leu Arg Ile Gly Thr Cys Gly Ala Ile Ser80 85 90 95CCA AAA GTT GGC CTG AAA GAC ATT ATC ATG GCG ACG GGG GCT TCA ACG 398Pro Lys Val Gly Leu Lys Asp Ile Ile Met Ala Thr Gly Ala Ser Thr
100 105 110GAT TCT AAA ACC AAT CGG GTG CGT TTT TTA AAC CAC GAT TTG AGC GCA 446Asp Ser Lys Thr Asn Arg Val Arg Phe Leu Asn His Asp Leu Ser Ala
115 120 125ACG CCT GAT TTT GAA TTG AGT TTA AGA GCG TAT CAA ACA GCA AAG CGT 494Thr Pro Asp Phe Glu Leu Ser Leu Arg Ala Tyr Gln Thr Ala Lys Arg
130 135 140TTG GGT ATT GAT TTG AAA GTG GGC AAT GTT TTT TCA AGC GAT TTT TTC 542Leu Gly Ile Asp Leu Lys Val Gly Asn Val Phe Ser Ser Asp Phe Phe
145 150155TAT TCT TTT GAA ACG CAT GCC TTT GAT TTA ATG GCT AAA TAC AAC CAC 590Tyr Ser Phe Glu Thr His Ala Phe Asp Leu Met Ala Lys Tyr Asn His160 165 170 175TTG GCT ATT GAA ATG GAA GCG GCG GGG TTA TAC GCC ACG GCG ATG GAA 638Leu Ala Ile Glu Met Glu Ala Ala Gly Leu Tyr Ala Thr Ala Met Glu
180 185 190CTA AAC GCT AAG GCT TTA TGC TTA TGC TCA GTC TCA GAT CAC TTA ATC 686Leu Asn Ala Lys Ala Leu Cys Leu Cys Ser Val Ser Asp His Leu Ile
195 200 205ACT AAA GAA GCC TTA AGC CCT AAA GAA AGG GTA GAA AGC TTT GAT AAC 734Thr Lys Glu Ala Leu Ser Pro Lys Glu Arg Val Glu Ser Phe Asp Asn
210 215 220ATG ATA ATT TTG GCT TTG GAG ATG ATG AGT TAGCCTTTTT TGCCCCCATA AGT 787Met Ile Ile Leu Ala Leu Glu Met Met Ser
225 230TAAGGATAAA ATTTAAAGGA AAACCCTTAA AGCTAAAAGC CTTAAGGGAA CTTTGG 843
(2) Sequence 518 data:
(i) sequence characteristics:
(A) length: 233 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 518: met Thr Pro His Ile Asn Ala Lys Ile Gly Asp Phe Tyr Pro Gln Cys 151015 Leu Leu Cys Gly Asp Pro Leu Arg Val Ser Tyr Ile Ala Lys Lys Phe
20 25 30Leu Gln Asp Ala Lys Glu Ile Thr Asn Val Arg Asn Met Leu Gly Phe
35 40 45Ser Gly Lys Tyr Lys Gly Arg Gly Ile Ser Leu Met Gly His Gly Met
50 55 60Gly Ile Ala Ser Cys Thr Ile Tyr Val Thr Glu Leu Ile Lys Thr Tyr65 70 75 80Gln Val Lys Glu Leu Leu Arg Ile Gly Thr Cys Gly Ala Ile Ser Pro
85 90 95Lys Val Gly Leu Lys Asp Ile Ile Met Ala Thr Gly Ala Ser Thr Asp
100 105 110Ser Lys Thr Asn Arg Val Arg Phe Leu Asn His Asp Leu Ser Ala Thr
115 120 125Pro Asp Phe Glu Leu Ser Leu Arg Ala Tyr Gln Thr Ala Lys Arg Leu
130 135 140Gly Ile Asp Leu Lys Val Gly Asn Val Phe Ser Ser Asp Phe Phe Tyr145 150 155 160Ser Phe Glu Thr His Ala Phe Asp Leu Met Ala Lys Tyr Asn His Leu
165 170 175Ala Ile Glu Met Glu Ala Ala Gly Leu Tyr Ala Thr Ala Met Glu Leu
180 185 190Asn Ala Lys Ala Leu Cys Leu Cys Ser Val Ser Asp His Leu Ile Thr
195 200 205Lys Glu Ala Leu Ser Pro Lys Glu Arg Val Glu Ser Phe Asp Asn Met
210 215 220Ile Ile Leu Ala Leu Glu Met Met Ser225 230
(2) Sequence 519 data:
(i) sequence characteristics:
(A) length: 1440bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 79...1407
(D) Other information:
(xi) Description of the sequence: sequence 519: TACATTAAAC TTTTATTATC AATCCTACTT CCTCAAATTG ATGACAAAAG TTGGGCATTT 60TCTTGTAAAA TAACCCGC ATG TTT AAG AAA ATT TTT CCA TTA GCG TTA GTG 111
Met Phe Lys Lys Ile Phe Pro Leu Ala Leu Val
1 5 10TCA TCG TTG CGG TTT TTG GGG CTT TTT ATT GTT TTG CCG GTC ATT AGT 159Ser Ser Leu Arg Phe Leu Gly Leu Phe Ile Val Leu Pro Val Ile Ser
15 20 25TTG TAT GCG GAT AGT TTC CAT TCA AGC AGT CCC TTA CTC GTG GGG TTG 207Leu Tyr Ala Asp Ser Phe His Ser Ser Ser Pro Leu Leu Val Gly Leu
30 35 40GCT GTG GGC GGA GCG TAT CTT ACG CAA ATT GTT TTT CAA ACC CCC ATG 255Ala Val Gly Gly Ala Tyr Leu Thr Gln Ile Val Phe Gln Thr Pro Met
45 50 55GGC ATT CTT AGC GAT AAG ATA GGC CGT AAA GTG GTG GTT ATG GTG TGC 303Gly Ile Leu Ser Asp Lys Ile Gly Arg Lys Val Val Val Met Val Cys60 65 70 75TTG CTG TTG TTT TTA GCC GGC TCG TTA GTG TGC TTT ATA GCG AAT GAT 351Leu Leu Leu Phe Leu Ala Gly Ser Leu Val Cys Phe Ile Ala Asn Asp
80 85 90ATT GTT TGG CTC GTT ATA GGG CGC TTC ATT CAA GGC ATG GGG GCT TTA 399Ile Val Trp Leu Val Ile Gly Arg Phe Ile Gln Gly Met Gly Ala Leu
95 100 105GGG GGG GTT ATT AGT GCG ATG GTG GCG GAT GAA GTG AAA GAA GAA GAG 447Gly Gly Val Ile Ser Ala Met Val Ala Asp Glu Val Lys Glu Glu Glu
110 115 120CGC ACC AAA GCC ATG GCC ATC ATG GGA GCG TTT ATT TTC ATT AGC TTC 495Arg Thr Lys Ala Met Ala Ile Met Gly Ala Phe Ile Phe Ile Ser Phe
125 130 135ACT ATA AGC ATG GCG ATT GGC CCT GGG GTT GTA GCG TTT TTG GGG GGG 543Thr Ile Ser Met Ala Ile Gly Pro Gly Val Val Ala Phe Leu Gly Gly140 145 150 155GCA AAA TGG CTC TTT TTA CTC ACG GCG ATC TTA ACT TTA TTG AGT TTA 591Ala Lys Trp Leu Phe Leu Leu Thr Ala Ile Leu Thr Leu Leu Ser Leu
160 165 170TTG ATG CTT TTA AAA GTC AAA GAC GCC CCT AAA ATT TCT TAC CAG ATC 639Leu Met Leu Leu Lys Val Lys Asp Ala Pro Lys Ile Ser Tyr Gln Ile
175 180 185AAA AAC ATA AAA GCT TAC CAA CCC AAC TCT AAA GCC TTG TAT CTT TTG 687Lys Asn Ile Lys Ala Tyr Gln Pro Asn Ser Lys Ala Leu Tyr Leu Leu
190 195 200TAT CTA AGC TCT TTT TTT GAA AAA GCG TTC ATG ACG CTT ATT TTT GTG 735Tyr Leu Ser Ser Phe Phe Glu Lys Ala Phe Met Thr Leu Ile Phe Val
205 210 215CTG ATC CCT TTA GCC TTA GTG AAT GAA TTT CAT AAA GAT GAA AGC TTT 783Leu Ile Pro Leu Ala Leu Val Asn Glu Phe His Lys Asp Glu Ser Phe220 225 230 235TTA ATC TTG GTG TAT GTG CCT GGA GCC TTA TTA GGG GTC TTA AGC ATG 831Leu Ile Leu Val Tyr Val Pro Gly Ala Leu Leu Gly Val Leu Ser Met
240 245 250GGA ATA GCG AGC GTT ATG GCT GAA AAA TAC AAC AAG CCT AAA GGA GTG 879Gly Ile Ala Ser Val Met Ala Glu Lys Tyr Asn Lys Pro Lys Gly Val
255 260 265ATG CTT TCT GGC GTA TTA TTG TTT ATT GTG AGT TAT TTG TGC TTG TTT 927Met Leu Ser Gly Val Leu Leu Phe Ile Val Ser Tyr Leu Cys Leu Phe
270 275 280TTA GCC GAC TCT AGC TTT TTA GGG AAA TAT TTA TGG CTT TTT ATT GTT 975Leu Ala Asp Ser Ser Phe Leu Gly Lys Tyr Leu Trp Leu Phe Ile Val
285 290 295GGG GTG GCG TTT TTC TTT ATT GGT TTT GCC ACC TTA GAG CCT ATC ATG 1023Gly Val Ala Phe Phe Phe Ile Gly Phe Ala Thr Leu Glu Pro Ile Met300 305 310 315CAA TCT TTA GCG TCT AAA TTC GCC AAA GTG CAT GAA AAA GGC AAG GTT 1071Gln Ser Leu Ala Ser Lys Phe Ala Lys Val His Glu Lys Gly Lys Val
320 325 330TTA GGG CAA TTC ACT ACT TTT GGC TAT TTA GGG AGC TTT GTT GGG GGC 1119Leu Gly Gln Phe Thr Thr Phe Gly Tyr Leu Gly Ser Phe Val Gly Gly
335 340 345GTG AGC GGG GGG TTG AGC TAC CAT CAT TTA GGC GTT TCT AAC ACA AGC 1167Val Ser Gly Gly Leu Ser Tyr His His Leu Gly Val Ser Asn Thr Ser
350 355 360TTG ATC GTT GTA GCT TTA GGG CTT ATT TGG GGG CTA TCG CTC TTT TTA 1215Leu Ile Val Val Ala Leu Gly Leu Ile Trp Gly Leu Ser Leu Phe Leu
365 370 375CTC AAC AAC CCT TCC AAG CAA AAA AAT GTC TAT TTC CCC TTA GAC GCT 1263Leu Asn Asn Pro Ser Lys Gln Lys Asn Val Tyr Phe Pro Leu Asp Ala380 385 390 395TAC AAT GAG GAA CAA TTT GAA ACT TTA GAG GAT AAA ATC ATT GAA TGG1311Tyr Asn Glu Glu Gln Phe Glu Thr Leu Glu Asp Lys Ile Ile Glu Trp
400 405 410TAT GTT AAT ATT AGC GAA GAA ATC ATT ATT GTG AAA TAT AAT TCC GAT 1359Tyr Val Asn Ile Ser Glu Glu Ile Ile Ile Val Lys Tyr Asn Ser Asp
415 420 425CAC ATT AGC GAA GAA GAA ATC ATT CAC TTA GCG CAA AAC TTT AGA AAA T 1408His Ile Ser Glu Glu Glu Ile Ile His Leu Ala Gln Asn Phe Arg Lys
430 435 440AAAACAATTA AGGATCAAAA ATGGCCTATG AA 1440
(2) Sequence 520 data:
(i) sequence characteristics:
(A) length: 443 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 520: met Phe Lys Lys Ile Phe Pro Leu Ala Leu Val Ser Ser Leu Arg Phe 151015 Leu Gly Leu Phe Ile Val Leu Pro Val Ile Ser Leu Tyr Ala Asp Ser
20 25 30Phe His Ser Ser Ser Pro Leu Leu Val Gly Leu Ala Val Gly Gly Ala
35 40 45Tyr Leu Thr Gln Ile Val Phe Gln Thr Pro Met Gly Ile Leu Ser Asp
50 55 60Lys Ile Gly Arg Lys Val Val Val Met Val Cys Leu Leu Leu Phe Leu65 70 75 80Ala Gly Ser Leu Val Cys Phe Ile Ala Asn Asp Ile Val Trp Leu Val
85 90 95Ile Gly Arg Phe Ile Gln Gly Met Gly Ala Leu Gly Gly Val Ile Ser
100 105 110Ala Met Val Ala Asp Glu Val Lys Glu Glu Glu Arg Thr Lys Ala Met
115 120 125Ala Ile Met Gly Ala Phe Ile Phe Ile Ser Phe Thr Ile Ser Met Ala
130 135 140Ile Gly Pro Gly Val Val Ala Phe Leu Gly Gly Ala Lys Trp Leu Phe145 150 155 160Leu Leu Thr Ala Ile Leu Thr Leu Leu Ser Leu Leu Met Leu Leu Lys
165 170 175Val Lys Asp Ala Pro Lys Ile Ser Tyr Gln Ile Lys Asn Ile Lys Ala
180 185 190Tyr Gln Pro Asn Ser Lys Ala Leu Tyr Leu Leu Tyr Leu Ser Ser Phe
195 200 205Phe Glu Lys Ala Phe Met Thr Leu Ile Phe Val Leu Ile Pro Leu Ala
210 215 220Leu Val Asn Glu Phe His Lys Asp Glu Ser Phe Leu Ile Leu Val Tyr225 230 235 240Val Pro Gly Ala Leu Leu Gly Val Leu Ser Met Gly Ile Ala Ser Val
245 250 255Met Ala Glu Lys Tyr Asn Lys Pro Lys Gly Val Met Leu Ser Gly Val
260 265 270Leu Leu Phe Ile Val Ser Tyr Leu Cys Leu Phe Leu Ala Asp Ser Ser
275 280 285Phe Leu Gly Lys Tyr Leu Trp Leu Phe Ile Val Gly Val Ala Phe Phe
290 295 300Phe Ile Gly Phe Ala Thr Leu Glu Pro Ile Met Gln Ser Leu Ala Ser305 310315 320Lys Phe Ala Lys Val His Glu Lys Gly Lys Val Leu Gly Gln Phe Thr
325 330 335Thr Phe Gly Tyr Leu Gly Ser Phe Val Gly Gly Val Ser Gly Gly Leu
340 345 350Ser Tyr His His Leu Gly Val Ser Asn Thr Ser Leu Ile Val Val Ala
355 360 365Leu Gly Leu Ile Trp Gly Leu Ser Leu Phe Leu Leu Asn Asn Pro Ser
370 375 380Lys Gln Lys Asn Val Tyr Phe Pro Leu Asp Ala Tyr Asn Glu Glu Gln385 390 395 400Phe Glu Thr Leu Glu Asp Lys Ile Ile Glu Trp Tyr Val Asn Ile Ser
405 410 415Glu Glu Ile Ile Ile Val Lys Tyr Asn Ser Asp His Ile Ser Glu Glu
420 425 430Glu Ile Ile His Leu Ala Gln Asn Phe Arg Lys
435 440
(2) Sequence 521 data:
(i) sequence characteristics:
(A) length: 1360bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 89...1237
(D) Other information:
(xi) Description of the sequence: sequence 521: GAAATCAAAA AAGGGGTTTT TACCACTTAT AAAGAGAAAA ACCCTATCGC TTTGAAAACT 60TAACCAATAA ATAAGGTAAA ATTAAGAC ATG CAT GCA GAA TTT TTC ACT TTC 112
Met His Ala Glu Phe Phe Thr Phe
1 5GCG CTC ATC ATG CTT TTA ATT GTG ATG GCC CCT TAT ATG TCT AGA ATC 160Ala Leu Ile Met Leu Leu Ile Val Met Ala Pro Tyr Met Ser Arg Ile
10 15 20TCT CGT TTG CCT ATC ACG GTT GTG GAG ATT TTA TTT GGA TCT GTT GGG 208Ser Arg Leu Pro Ile Thr Val Val Glu Ile Leu Phe Gly Ser Val Gly25 30 35 40GCG TAT GTG GGT TTT ATT GAG CCT ACT AAG GGC TTT GAA ATC ATG TCC 256Ala Tyr Val Gly Phe Ile Glu Pro Thr Lys Gly Phe Glu Ile Met Ser
45 50 55GAA ATT GGC TTT TTG TTT TTA ATG TTT TTA TGC GGT TTG GAA GTG GAG 304Glu Ile Gly Phe Leu Phe Leu Met Phe Leu Cys Gly Leu Glu Val Glu
60 65 70ATT TAT CTG TTC AAA AAA TTA GGG GTT TCT CTT TTA AAA CGC ATT TTT 352Ile Tyr Leu Phe Lys Lys Leu Gly Val Ser Leu Leu Lys Arg Ile Phe
75 80 85GCT TAT CTG TTG ATT TTA TAC ACG CTT TCG TTT ATT CTT ACT TTT AGC 400Ala Tyr Leu Leu Ile Leu Tyr Thr Leu Ser Phe Ile Leu Thr Phe Ser
90 95 100CTT AAT TTA GAG CCT ATT TTT ATG GTG ATT TTC CCT ATT ATT AGT TTG 448Leu Asn Leu Glu Pro Ile Phe Met Val Ile Phe Pro Ile Ile Ser Leu105 110 115 120GGC ATG ATC ATG ACT TTA GTC AAA GAT TAT CGT AAA GAG ATT TTG TGG 496Gly Met Ile Met Thr Leu Val Lys Asp Tyr Arg Lys Glu Ile Leu Trp
125 130 135CTT GAT TTG GTT TTG AAA GTG GGC GTT ATT GGG GAA TTG TTA AGC ATT 544Leu Asp Leu Val Leu Lys Val Gly Val Ile Gly Glu Leu Leu Ser Ile
140 145 150TTT GGT TTG GTG GTC GTG GAT GGG GTG TAT TCG CAT GGT TTG GGC ATG 592Phe Gly Leu Val Val Val Asp Gly Val Tyr Ser His Gly Leu Gly Met
155 160 165GAT TTG ATT AAA GAT TTA GGC ATT CTC ATT GTT TTT TTA ATC TTA ATT 640Asp Leu Ile Lys Asp Leu Gly Ile Leu Ile Val Phe Leu Ile Leu Ile
170 175 180ATC GTG GCG TTT CAA ATC TTT AAG ACT TTG TTT TGG TGG TTC CCG CAT 688Ile Val Ala Phe Gln Ile Phe Lys Thr Leu Phe Trp Trp Phe Pro His185 190 195 200TTA AAG CTT TTT GTG ATG CCT AAA AGC AGT CAG TTT AAC CAA GAT GTG 736Leu Lys Leu Phe Val Met Pro Lys Ser Ser Gln Phe Asn Gln Asp Val
205 210 215CGT TTT TCG CTC ATG CTC TTT TTT TCC TTA GTT GCG ATC GTG GTG TGG 784Arg Phe Ser Leu Met Leu Phe Phe Ser Leu Val Ala Ile Val Val Trp
220 225 230CTC AAA ATA GAA ATG GTT TTA GGG GCG TTT CTA GCA GGG TTA GTC GTT 832Leu Lys Ile Glu Met Val Leu Gly Ala Phe Leu Ala Gly Leu Val Val
235 240 245TCT ACT TTT TTC CCT CAT AAA TCA GAA TTG ATC CAC AAG CTC AAT GAT 880Ser Thr Phe Phe Pro His Lys Ser Glu Leu Ile His Lys Leu Asn Asp
250 255 260GTG GGT TTT GGG TTT TTT GTG CCT TTG TTT TTC ATC CAT GTA GGC TCT 928Val Gly Phe Gly Phe Phe Val Pro Leu Phe Phe Ile His Val Gly Ser265 270 275 280ACT TTA GAC TTA AAA TTA GTG TTT TTA AAC CCG CAT TTG ATT CTC CAA 976Thr Leu Asp Leu Lys Leu Val Phe Leu Asn Pro His Leu Ile Leu Gln
285 290 295GGG ATA TTG ATT GTC ATA GCG ATG TTG AGT TTG CAC TTG ATC ACT TCA 1024Gly Ile Leu Ile Val Ile Ala Met Leu Ser Leu His Leu Ile Thr Ser
300 305 310ACC TTA TTG TGG CGC AAA TAC TTT AAA GAG GCT AAG CAT TTA TTT TCA 1072Thr Leu Leu Trp Arg Lys Tyr Phe Lys Glu Ala Lys His Leu Phe Ser
315 320 325TTC GCT TTA GGG GCT TCT ATG CCT TTA ACT TTT TTA GTA ACC ACC GCA 1120Phe Ala Leu Gly Ala Ser Met Pro Leu Thr Phe Leu Val Thr Thr Ala
330 335 340GCA GTA GGC TTA AAA GCG CAA GCG ATC TCA CAA AAC ACC TAC TAC GCA 1168Ala Val Gly Leu Lys Ala Gln Ala Ile Ser Gln Asn Thr Tyr Tyr Ala345 350 355 360TTG CTC ATG GCG GCT ATT TTT GAA GGG GTA TTA TTC ACG ATT GCG ATC 1216Leu Leu Met Ala Ala Ile Phe Glu Gly Val Leu Phe Thr Ile Ala Ile
365 370 375AAA ATA CTC AAC AAA AAA GCT TGAATGAAAG CTTAAGCGTC TAAATATTTA GCGT 1271Lys Ile Leu Asn Lys Lys Ala
380CGCTAAAGCT GTTCGCTTGA ACATTATTGA ACGCATTCTC TAAGCTATCA AAGAAACGAG 1331GGTGCAAGTT TTGCATTTCT TTTAAGAAA 1360
(2) Sequence 522 data:
(i) sequence characteristics:
(A) length: 383 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 522: met His Ala Glu Phe Phe Thr Phe Ala Leu Ile Met Leu Leu Ile Val 151015 Met Ala Pro Tyr Met Ser Arg Ile Ser Arg Leu Pro Ile Thr Val Val
20 25 30Glu Ile Leu Phe Gly Ser Val Gly Ala Tyr Val Gly Phe Ile Glu Pro
35 40 45Thr Lys Gly Phe Glu Ile Met Ser Glu Ile Gly Phe Leu Phe Leu Met
50 55 60Phe Leu Cys Gly Leu Glu Val Glu Ile Tyr Leu Phe Lys Lys Leu Gly65 70 75 80Val Ser Leu Leu Lys Arg Ile Phe Ala Tyr Leu Leu Ile Leu Tyr Thr
85 90 95Leu Ser Phe Ile Leu Thr Phe Ser Leu Asn Leu Glu Pro Ile Phe Met
100 105 110Val Ile Phe Pro Ile Ile Ser Leu Gly Met Ile Met Thr Leu Val Lys
115 120 125Asp Tyr Arg Lys Glu Ile Leu Trp Leu Asp Leu Val Leu Lys Val Gly
130 135 140Val Ile Gly Glu Leu Leu Ser Ile Phe Gly Leu Val Val Val Asp Gly145 150 155 160Val Tyr Ser His Gly Leu Gly Met Asp Leu Ile Lys Asp Leu Gly Ile
165 170 175Leu Ile Val Phe Leu Ile Leu Ile Ile Val Ala Phe Gln Ile Phe Lys
180 185 190Thr Leu Phe Trp Trp Phe Pro His Leu Lys Leu Phe Val Met Pro Lys
195 200 205Ser Ser Gln Phe Asn Gln Asp Val Arg Phe Ser Leu Met Leu Phe Phe
210 215 220Ser Leu Val Ala Ile Val Val Trp Leu Lys Ile Glu Met Val Leu Gly225 230 235 240Ala Phe Leu Ala Gly Leu Val Val Ser Thr Phe Phe Pro His Lys Ser
245 250 255Glu Leu Ile His Lys Leu Asn Asp Val Gly Phe Gly Phe Phe Val Pro
260 265 270Leu Phe Phe Ile His Val Gly Ser Thr Leu Asp Leu Lys Leu Val Phe
275 280 285Leu Asn Pro His Leu Ile Leu Gln Gly Ile Leu Ile Val Ile Ala Met
290 295 300Leu Ser Leu His Leu Ile Thr Ser Thr Leu Leu Trp Arg Lys Tyr Phe305 310 315 320Lys Glu Ala Lys His Leu Phe Ser Phe Ala Leu Gly Ala Ser Met Pro
325 330 335Leu Thr Phe Leu Val Thr Thr Ala Ala Val Gly Leu Lys Ala Gln Ala
340 345 350Ile Ser Gln Asn Thr Tyr Tyr Ala Leu Leu Met Ala Ala Ile Phe Glu
355 360 365Gly Val Leu Phe Thr Ile Ala Ile Lys Ile Leu Asn Lys Lys Ala
370 375 380
(2) Sequence 523 data:
(i) sequence characteristics:
(A) length: 1024bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 115..92l
(D) Other information:
(xi) Description of the sequence: sequence 523: AGTTGGCAAA AACGCAGAGA CAGTAACGCA AAGGCAAATA AAGAGACTCA TTTTAAACAA 60GCGAATGCCA TTACAAATAT AATCAGATCA GTTGGTGGGT TTTTTACAAA GATT ATG 117
Met
1AAG AGA GTT AGA GAA CTT GTA AAA AAA CAT CCC GAG AAA ACC AGT GTG 165Lys Arg Val Arg Glu Leu Val Lys Lys His Pro Glu Lys Ser Ser Val
5 10 15GCA TTA GTA GTA TTA ACC CAT GCT GCA TGC AAG AAA GCG AAA GAA TTG 213Ala Leu Val Val Leu Thr His Ala Ala Cys Lys Lys Ala Lys Glu Leu
20 25 30GAC GAT AAA GTC CAG GAT AAA TCC AAA CAA GCT GAA AAA GAA AAT CAA 261Asp Asp Lys Val Gln Asp Lys Ser Lys Gln Ala Glu Lys Glu Asn Gln
35 40 45ATC AAT TGG TGG AAA TAT TCA GGA TTA ACA ATA GCG ACA AGT TTA TTA 309Ile Asn Trp Trp Lys Tyr Ser Gly Leu Thr Ile Ala Thr Ser Leu Leu50 55 60 65TTA GCC GCT TGT AGT GTT GGT GAT ATT GAT AAA CAG ATA GAG TTA GAA 357Leu Ala Ala Cys Ser Val Gly Asp Ile Asp Lys Gln Ile Glu Leu Glu
70 75 80CAA GAA AAA AAG GAA GCT GAA AAC GCT AGG GAT AGA GCG AAC AAG AGT 405Gln Glu Lys Lys Glu Ala Glu Asn Ala Arg Asp Arg Ala Asn Lys Ser
85 90 95GGG ATA GAA CTG GAA CAG GAA AAA CAA AAG ACC ATT AAA GAA CAA AAA 453Gly Ile Glu Leu Glu Gln Glu Lys Gln Lys Thr Ile Lys Glu Gln Lys
100 105 110GAT TTA GTT AAA AAA GCA GAA CAA AAT TGC CAA GAA AAT CAT GGC CAA 501Asp Leu Val Lys Lys Ala Glu Gln Asn Cys Gln Glu Asn His Gly Gln
115 120 125TTC TTT ATG AAA AAA TTA GGA ATT AAG GGT GGC ATT GCT ATA GAA GTA 549Phe Phe Met Lys Lys Leu Gly Ile Lys Gly Gly Ile Ala Ile Glu Val130 135 140 145GAA GCT GAA TGC AAA ACC CCT AAA CCT GCA AAA ACC AAT CAA ACC CCT 597Glu Ala Glu Cys Lys Thr Pro Lys Pro Ala Lys Thr Asn Gln Thr Pro
150 155 160ATC CAG CCA AAA CAC CTC CCC AAC TCT AAA CAA CCC CAC TCT CAA AGA 645Ile Gln Pro Lys His Leu Pro Asn Ser Lys Gln Pro His Ser Gln Arg
165 170 175GGA TCA AAA GCG CAA GAG CTT ATC GCT TAT TTG CAA AAA GAG TTA GAA 693Gly Ser Lys Ala Gln Glu Leu Ile Ala Tyr Leu Gln Lys Glu Leu Glu
180 185 190TCT CTG CCC TAT TCA CAA AAA GCT ATC GCT AAA CAA GTG AAT TTT TAC 741Ser Leu Pro Tyr Ser Gln Lys Ala Ile Ala Lys Gln Val Asn Phe Tyr
195 200 205AGG CCA AGT TCT GTC GCT TAT TTA GAA CTA GAC CCT AGA GAT TTT AAG 789Arg Pro Ser Ser Val Ala Tyr Leu Glu Leu Asp Pro Arg Asp Phe Lys210 215 220 225GTT ACA GAA GAA TGG CAA AAA GAA AAT CTA AAA ATA CGC TCT AAA GCT 837Val Thr Glu Glu Trp Gln Lys Glu Asn Leu Lys Ile Arg Ser Lys Ala
230 235 240CAA GCT AAA ATG CTT GGA AAT GAG AAA CCC ACA AGC CCA CCT TTC AAC 885Gln Ala Lys Met Leu Gly Asn Glu Lys Pro Thr Ser Pro Pro Phe Asn
245 250 255CTC TCA AAG CCT TTT GTT CGT TCA AAA AAT ATT TGC TGATGTTAAT AAAGAA 937Leu Ser Lys Pro Phe Val Arg Ser Lys Asn IleCys
260 265ATAGAAGCAG TTGCTAATAC TGAAAAGAAA GCAGAAAAAG MGGGTTATGG TTATAGTAAA 997AGGATGTAGG CATAAGAAAA TAAGAAC 1024
(2) Sequence 524 data:
(i) sequence characteristics:
(A) length: 269 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 524: met Lys Arg Val Arg Glu Leu Val Lys Lys His Pro Glu Lys Ser Ser 151015 Val Ala Leu Val Val Leu Thr His Ala Ala Cys Lys Lys Ala Lys Glu
20 25 30Leu Asp Asp Lys Val Gln Asp Lys Ser Lys Gln Ala Glu Lys Glu Asn
35 40 45Gln Ile Asn Trp Trp Lys Tyr Ser Gly Leu Thr Ile Ala Thr Ser Leu
50 55 60Leu Leu Ala Ala Cys Ser Val Gly Asp Ile Asp Lys Gln Ile Glu Leu65 70 75 80Glu Gln Glu Lys Lys Glu Ala Glu Asn Ala Arg Asp Arg Ala Asn Lys
85 90 95Ser Gly Ile Glu Leu Glu Gln Glu Lys Gln Lys Thr Ile Lys Glu Gln
100 105 110Lys Asp Leu Val Lys Lys Ala Glu Gln Asn Cys Gln Glu Asn His Gly
115 120 125Gln Phe Phe Met Lys Lys Leu Gly Ile Lys Gly Gly Ile Ala Ile Glu
130135 140Val Glu Ala Glu Cys Lys Thr Pro Lys Pro Ala Lys Thr Asn Gln Thr145 150 155 160Pro Ile Gln Pro Lys His Leu Pro Asn Ser Lys Gln Pro His Ser Gln
165 170 175Arg Gly Ser Lys Ala Gln Glu Leu Ile Ala Tyr Leu Gln Lys Glu Leu
180 185 190Glu Ser Leu Pro Tyr Ser Gln Lys Ala Ile Ala Lys Gln Val Asn Phe
195 200 205Tyr Arg Pro Ser Ser Val Ala Tyr Leu Glu Leu Asp Pro Arg Asp Phe
210 215 220Lys Val Thr Glu Glu Trp Gln Lys Glu Asn Leu Lys Ile Arg Ser Lys225 230 235 240Ala Gln Ala Lys Met Leu Gly Asn Glu Lys Pro Thr Ser Pro Pro Phe
245 250 255Asn Leu Ser Lys Pro Phe Val Arg Ser Lys Asn Ile Cys
260 265
(2) Sequence 525 data:
(i) sequence characteristics:
(A) length: 535bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...482
(D) Other information:
(xi) Description of the sequence: sequence 525: GTGATCCCTA AAGAATATAT CCTGCGGTGG ATAAGGGTAT CCAAGAAGCG ATG CAA 56
Met Gln
1AAT GGC GTT TTG GCA GGC TAT CCG GTG GTG GAT TIT AAA GTT ACC CTT 104Asn Gly Val Leu Ala Gly Tyr Pro Val Val Asp Phe Lys Val Thr Leu
5 10 15TAT GAT GGG AGC TAC CAT GAT GTG GAT TCT TCA GAA ATG GCG TTT AAA 152Tyr Asp Gly Ser Tyr His Asp Val Asp Ser Ser Glu Met Ala Phe Lys
20 25 30ATC GCT GGC TCT ATG GCG TTT AAA GAA GCG AGT CGC GCG GCT AAC CCG 200Ile Ala Gly Ser Met Ala Phe Lys Glu Ala Ser Arg Ala Ala Asn Pro35 40 45 50GTT TTA CTA GAG CCT ATG ATG AAA GTG GAA GTG GAA GTC CCT GAA GAA 248Val Leu Leu Glu Pro Met Met Lys Val Glu Val Glu Val Pro Glu Glu
55 60 65TAC ATG GGC GAT GTG ATT GGC GAT TTG AAT AGA AGA AGA GGG CAA ATC 296Tyr Met Gly Asp Val Ile Gly Asp Leu Asn Arg Arg Arg Gly Gln Ile
70 75 80AAT TCT ATG GAC GAT AGA TTA GGC TTG AAA ATC GTG AAC GCT TTT GTG 344Asn Ser Met Asp Asp Arg Leu Gly Leu Lys Ile Val Asn Ala Phe Val
85 90 95CCG TTG GTG GAA ATG TTT GGC TAT TCT ACG GAT TTA CGA TCA GCC ACC 392Pro Leu Val Glu Met Phe Gly Tyr Ser Thr Asp Leu Arg Ser Ala Thr
100 105 110CAA GGG CGT GGG ACT TAC TCT ATG GAG TTT GAT CAT TAT GGC GAA GTG 440Gln Gly Arg Gly Thr Tyr Ser Met Glu Phe Asp His Tyr Gly Glu Val115 120 125 130CCT AGC AAT ATC GCT AAG GAA ATT GTA GAA AAG CGC AAA GGC TGATTTAAT 491Pro Ser Asn Ile Ala Lys Glu Ile Val Glu Lys Arg Lys Gly
135 140TATAACGCTC TCTTATTTTT AGGGGGTGTT ATAGGTGCTG TTTA 535
(2) Sequence 526 data:
(i) sequence characteristics:
(A) length: 144 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 526: met Gln Asn Gly Val Leu Ala Gly Tyr Pro Val Val Asp Phe Lys Val 151015 Thr Leu Tyr Asp Gly Ser Tyr His Asp Val Asp Ser Ser Glu Met Ala
20 25 30Phe Lys Ile Ala Gly Ser Met Ala Phe Lys Glu Ala Ser Arg Ala Ala
35 40 45Asn Pro Val Leu Leu Glu Pro Met Met Lys Val Glu Val Glu Val Pro
50 55 60Glu Glu Tyr Met Gly Asp Val Ile Gly Asp Leu Asn Arg Arg Arg Gly65 70 75 80Gln Ile Asn Ser Met Asp Asp Arg Leu Gly Leu Lys Ile Val Asn Ala
85 90 95Phe Val Pro Leu Val Glu Met Phe Gly Tyr Ser Thr Asp Leu Arg Ser
100 105 110Ala Thr Gln Gly Arg Gly Thr Tyr Ser Met Glu Phe Asp His Tyr Gly
115 120 125Glu Val Pro Ser Asn Ile Ala Lys Glu Ile Val Glu Lys Arg Lys Gly
130 135 140
(2) Sequence 527 data:
(i) sequence characteristics:
(A) length: 740bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...671
(D) Other information:
(xi) Description of the sequence: sequence 527: CTCTCTCTTC AAGCTTGGAT AACAAATGCG GTTTGAAGAG TTCTAACGCC ATG TTT 56
Met Phe
1TTA GGC AAC CCG CAT TCA TCC ATT TTG AGA TTA GGC CCA ACC ACA ATC 104Leu Gly Asn Pro His Ser Ser Ile Leu Arg Leu Gly Pro Thr Thr Ile
5 10 15ACG CTT CTG CCT GAA AAA TCC ACG CGC TTA CCT AAA AGG TTT TGC CTG 152Thr Leu Leu Pro Glu Lys Ser Thr Arg Leu Pro Lys Arg Phe Cys Leu
20 25 30AAA CGC CCC TGC TTG CCT TTA ATG ATT TCA CTG AGC GAT TTT AAA GGG 200Lys Arg Pro Cys Leu Pro Leu Met Ile Ser Leu Ser Asp Phe Lys Gly35 40 45 50CGT TTG TTA GCC CCT TTA ACC GCA TTA GTG CTG CGG CCG TTA TCA AAA 248Arg Leu Leu Ala Pro Leu Thr Ala Leu Val Leu Arg Pro Leu Ser Lys
55 60 65AGC ACA TCC ACG GCT TCT TGC AAC ATC CTT TTT TCA TTG CGC ACA ATG 296Ser Thr Ser Thr Ala Ser Cys Asn Ile Leu Phe Ser Leu Arg Thr Met
7075 80ATT TCT GGC GCT CCA AGC TCC ATT AAG CGT TTC AAG CGT TGG TTA CGA 344Ile Ser Gly Ala Pro Ser Ser Ile Lys Arg Phe Lys Arg Trp Leu Arg
85 90 95TTG ATG ACA CGA CGA TAC AAT TCA TTC ACA TCG CTG ACT GCA AAC TTC 392Leu Met Thr Arg Arg Tyr Asn Ser Phe Thr Ser Leu Thr Ala Asn Phe
100 105 110CCG CCA TCT AGC GCG ACT AAA GGC CTT AAA TCC GGT GGC AAT ACC GGT 440Pro Pro Ser Ser Ala Thr Lys Gly Leu Lys Ser Gly Gly Asn Thr Gly115 120 125 130AAA ACC GTG AGC ATC ATC CAT TCA GGC CTA TTA CCA GAA TTT AAA AAG 488Lys Thr Val Ser Ile Ile His Ser Gly Leu Leu Pro Glu Phe Lys Lys
135 140 145CTT TCT ACC ACT TTC AAA CGC TTA ATG AGT TTT TTC TTT TTC GCA TCA 536Leu Ser Thr Thr Phe Lys Arg Leu Met Ser Phe Phe Phe Phe Ala Ser
150 155 160GAA TTG GTG TCT TTC ACT TCT TCT TTC AAA CTC TGC AAT AAG GTG ATC 584Glu Leu Val Ser Phe Thr Ser Ser Phe Lys Leu Cys Asn Lys Val Ile
165 170 175AAA TCA ATT TCT TCT AAC AAA TCC TTG ATC GCT TCA CCG CCC ATT TGC 632Lys Ser Ile Ser Ser Asn Lys Ser Leu Ile Ala Ser Pro Pro Ile Cys
180 185 190GCT ACA AAG CCC CTG TCT TCG TAT CTT CGT GAG ATA TTT TGATACTGCT CT 683Ala Thr Lys Pro Leu Ser Ser Tyr Leu Arg Glu Ile Phe195 200 205TCATTCAAAA TATCGTATTT CATCACAAGC TTAGTGCCTT CATTGTCATA AGCGGCT 740
(2) Sequence 528 data:
(i) sequence characteristics:
(A) length: 207 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 528: met Phe Leu Gly Asn Pro His Ser Ser Ile Leu Arg Leu Gly Pro Thr 151015 Thr Ile Thr Leu Leu Pro Glu Lys Ser Thr Arg Leu Pro Lys Arg Phe
20 25 30Cys Leu Lys Arg Pro Cys Leu Pro Leu Met Ile Ser Leu Ser Asp Phe
35 40 45Lys Gly Arg Leu Leu Ala Pro Leu Thr Ala Leu Val Leu Arg Pro Leu
50 55 60Ser Lys Ser Thr Ser Thr Ala Ser Cys Asn Ile Leu Phe Ser Leu Arg65 70 75 80Thr Met Ile Ser Gly Ala Pro Ser Ser Ile Lys Arg Phe Lys Arg Trp
85 90 95Leu Arg Leu Met Thr Arg Arg Tyr Asn Ser Phe Thr Ser Leu Thr Ala
100 105 110Asn Phe Pro Pro Ser Ser Ala Thr Lys Gly Leu Lys Ser Gly Gly Asn
115 120 125Thr Gly Lys Thr Val Ser Ile Ile His Ser Gly Leu Leu Pro Glu Phe
130 135 140Lys Lys Leu Ser Thr Thr Phe Lys Arg Leu Met Ser Phe Phe Phe Phe145 150 155 160Ala Ser Glu Leu Val Ser Phe Thr Ser Ser Phe Lys Leu Cys Asn Lys
165 170 175Val Ile Lys Ser Ile Ser Ser Asn Lys Ser Leu Ile Ala Ser Pro Pro
180 185190Ile Cys Ala Thr Lys Pro Leu Ser Ser Tyr Leu Arg Glu Ile Phe
195 200 205
(2) Sequence 529 data:
(i) sequence characteristics:
(A) length: 505bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...411
(D) Other information:
(xi) Description of the sequence: sequence 529: CAA TGT GGT GAG AGA GAT TTT AGA GGG CTT TTC TTT CAA GCA ATA CGA 48Gln Cys Gly Glu Arg Asp Phe Arg Gly Leu Phe Phe Gln Ala Ile Arg 151015 GTG TCT AAT TAC GCT AGA AAT TAT CAA GTC AAA CAC AAC TTG GCT TAC 96Val Ser Asn Tyr Ala Arg Asn Tyr Gln Val Lys His Asn Leu Ala Tyr
20 25 30TGG GGG GCT AAA GAT TAT TTA GGG TGC GGG GCT GGG GCT GTG GGC TGC 144Trp Gly Ala Lys Asp Tyr Leu Gly Cys Gly Ala Gly Ala Val Gly Cys
35 40 45GTG GCG AAT GAG CGC TTT TTT GCA AAA AAA CTC ATA GAA AAC TAC ATC 192Val Ala Asn Glu Arg Phe Phe Ala Lys Lys Leu Ile Glu Asn Tyr Ile
50 55 60AAA GAC CCC CTA CAA CGC CAA GTT GAG ACG CTT AAT AAA CAA GAC AAA 240Lys Asp Pro Leu Gln Arg Gln Val Glu Thr Leu Asn Lys Gln Asp Lys65 70 75 80CGC TTA GAA AAG CTG TTT TTA GGC TTG AGG TGC GTG CTT GGG GTT GAG 288Arg Leu Glu Lys Leu Phe Leu Gly Leu Arg Cys Val Leu Gly Val Glu
85 90 95CTT AGT TTC TTA GAT GAA AAT AAA GTA AAG TTT TTG ATT GAA GAG AAC 336Leu Ser Phe Leu Asp Glu Asn Lys Val Lys Phe Leu Ile Glu Glu Asn
100 105 110AAG GCT TTC ATT AAA AAT AAC CGC TTG ATA GCG AGC GAT TTT TTC ATG 384Lys Ala Phe Ile Lys Asn Asn Arg Leu Ile Ala Ser Asp Phe Phe Met
115 120 125GCC GAT GAA ATG GCT TTG TGG CTG TTA TGATTGTAGG CTTTGCTTCA ATCAAGC 438Ala Asp Glu Met Ala Leu Trp Leu Leu
130 135GTTAATAAAA CGCTAGAAAG CGTTTTTTAA TGAATGCCTA CAAAATTTTT AGCCAAAAAC 498CAACCAA 505
(2) Sequence 530 data:
(i) sequence characteristics:
(A) length: 137 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 530: gln Cys Gly Glu Arg Asp Phe Arg Gly Leu Phe Phe Gln Ala Ile Arg 151015 Val Ser Asn Tyr Ala Arg Asn Tyr Gln Val Lys His Asn Leu Ala Tyr
20 25 30Trp Gly Ala Lys Asp Tyr Leu Gly Cys Gly Ala Gly Ala Val Gly Cys
35 40 45Val Ala Asn Glu Arg Phe Phe Ala Lys Lys Leu Ile Glu Asn Tyr Ile
50 55 60Lys Asp Pro Leu Gln Arg GlnVal Glu Thr Leu Asn Lys Gln Asp Lys65 70 75 80Arg Leu Glu Lys Leu Phe Leu Gly Leu Arg Cys Val Leu Gly Val Glu
85 90 95Leu Ser Phe Leu Asp Glu Asn Lys Val Lys Phe Leu Ile Glu Glu Asn
100 105 110Lys Ala Phe Ile Lys Asn Asn Arg Leu Ile Ala Ser Asp Phe Phe Met
115 120 125Ala Asp Glu Met Ala Leu Trp Leu Leu
130 135
(2) Sequence 531 data:
(i) sequence characteristics:
(A) length: 1260bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 55...1179
(D) Other information:
(xi) Description of the sequence: sequence 531: GTTGGTGTTT GAAAGGCTCT ATGAAGAAGA ATTAAGGCGC AAGGGTTTTT TATA ATG 57
Met
1GTC TCT CTC TAT TTA GAA AAC GGG CTT TTT TTG CAA GCG CAA AGT TTT 105Val Ser Leu Tyr Leu Glu Asn Gly Leu Phe Leu Gln Ala Gln Ser Phe
5 10 15GGG GCT AGC GGC ACG CAA GCG GGC GAG CTT GTT TTT AAC ACT TCT ATG 153Gly Ala Ser Gly Thr Gln Ala Gly Glu Leu Val Phe Asn Thr Ser Met
20 25 30AGC GGT TAT CAA GAA GTC ATT AGC GAC CCT AGC TAT AAG GGG CAA TTT 201Ser Gly Tyr Gln Glu Val Ile Ser Asp Pro Ser Tyr Lys Gly Gln Phe
35 40 45GTG GTT TTT AGC ATG CCT GAG ATT GGG GTT GTG GGT GCT AAT TCT AAA 249Val Val Phe Ser Met Pro Glu Ile Gly Val Val Gly Ala Asn Ser Lys50 55 60 65GAT GAT GAA TCC TTT TTT TCA TGC GCA GGG GTT TTA GCG CGC CAT TAC 297Asp Asp Glu Ser Phe Phe Ser Cys Ala Gly Val Leu Ala Arg His Tyr
70 75 80AAC GAA TTT TTT TCT AAC TCA AGG GCG GAT TTT AGC TTG AGC GCT TAT 345Asn Glu Phe Phe Ser Asn Ser Arg Ala Asp Phe Ser Leu Ser Ala Tyr
85 90 95TTG AAA GAG CGT GGC GTT TTA GGG GTT TGT GGC GTT GAT ACT AGG AGT 393Leu Lys Glu Arg Gly Val Leu Gly Val Cys Gly Val Asp Thr Arg Ser
100 105 110TTG ATT AAA ACC TTA CGC CAT CAT GGG TGC TTA ATG ATG GTC GCT TCC 441Leu Ile Lys Thr Leu Arg His His Gly Cys Leu Met Met Val Ala Ser
115 120 125ACG ATA GAG CAT GAC AAA AAC AAG CTT GAA GAA ATT TTA AAA AAC GCT 489Thr Ile Glu His Asp Lys Asn Lys Leu Glu Glu Ile Leu Lys Asn Ala130 135 140 145CCT AAA ATT TCT CAC TCC CCC CTA GTG TCT AGC GTT TCT ACG CCA AAA 537Pro Lys Ile Ser His Ser Pro Leu Val Ser Ser Val Ser Thr Pro Lys
150 155 160ATA ACC ACG CAC CAG CGT GCG ACT TTT GAT TTC AAA ACC CTA GAT TAC 585Ile Thr Thr His Gln Arg Ala Thr Phe Asp Phe Lys Thr Leu Asp Tyr
165 170175AAG CCT TTT GAT GAA AAA ACC TCT CAT AAA ATT ATC GCG GTG TTA GAC 633Lys Pro Phe Asp Glu Lys Thr Ser His Lys Ile Ile Ala Val Leu Asp
180 185 190TTT GGG GCT AAG GGC AAT ATT TTA AAC GAG CTT CAA AAT GTG GGG TTA 681Phe Gly Ala Lys Gly Asn Ile Leu Asn Glu Leu Gln Asn Val Gly Leu
195 200 205AAA GCC CTT ATT TAC CCG CAC CAC ACT AAA GCT AGC GAG CTG ATT AAA 729Lys Ala Leu Ile Tyr Pro His His Thr Lys Ala Ser Glu Leu Ile Lys210 215 220 225GCC TAT GAA AAA AAA GAA ATT AGC GGG ATT TTC CTC TCT AAC GGG CCG 777Ala Tyr Glu Lys Lys Glu Ile Ser Gly Ile Phe Leu Ser Asn Gly Pro
230 235 240GGC GAT CCT TTA AGC TTG CAG CAA GAA ATT GGC GAA ATC AAA CAA CTC 825Gly Asp Pro Leu Ser Leu Gln Gln Glu Ile Gly Glu Ile Lys Gln Leu
245 250 255ATT AAC GCT AAA ATC CCC ATG CTT GGC ATT TGC TTA GGG CAT CAA TTG 873Ile Asn Ala Lys Ile Pro Met Leu Gly Ile Cys Leu Gly His Gln Leu
260 265 270CTC TCT ATC GCT CAA GGC TAC CCT ACT TAC AAG CTC AAA TTT GGT CAT 921Leu Ser Ile Ala Gln Gly Tyr Pro Thr Tyr Lys Leu Lys Phe Gly His
275 280 285CAT GGG AGC AAC CAC CCC GTT AAA AAC CTA AAA ACA AAC GCC GTA GAA 969His Gly Ser Asn His Pro Val Lys Asn Leu Lys Thr Asn Ala Val Glu290 295 300 305ATC ACC GCG CAA AAC CAC AAC TAT TGC GTC CCT GAA GAC ATT GAA GAA 1017Ile Thr Ala Gln Asn His Asn Tyr Cys Val Pro Glu Asp Ile Glu Glu
310 315 320ATC GCC ATT ATC ACG CAC CGC AAT CTT TTT GAC AAC ACC ATTGAG GGC 1065Ile Ala Ile Ile Thr His Arg Asn Leu Phe Asp Asn Thr Ile Glu Gly
325 330 335GTG CGT TAT AAA AAC GCT CCC ATT ATC TCT GTC CAG CAC CAC CCA GAA 1113Val Arg Tyr Lys Asn Ala Pro Ile Ile Ser Val Gln His His Pro Glu
340 345 350AGT AGC CCA GGT CCT AAA GAG AGC CAC TAT ATT TTT AAA GAA TTT GTG 1161Ser Ser Pro Gly Pro Lys Glu Ser His Tyr Ile Phe Lys Glu Phe Val
355 360 365GAA TTG TTA AAG GAT TTT TAGGGGTTTT TAAAACAGCG CTTATAGAGA CTGAAAAG 1217Glu Leu Leu Lys Asp Phe370 375CGCTTTAAAA ATAGATTTAA ATCTTTTTAT CAAAAAATCT CGC 1260
(2) Sequence 532 data:
(i) sequence characteristics:
(A) length: 375 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 532: met Val Ser Leu Tyr Leu Glu Asn Gly Leu Phe Leu Gln Ala Gln Ser 151015 Phe Gly Ala Ser Gly Thr Gln Ala Gly Glu Leu Val Phe Asn Thr Ser
20 25 30Met Ser Gly Tyr Gln Glu Val Ile Ser Asp Pro Ser Tyr Lys Gly Gln
35 40 45Phe Val Val Phe Ser Met Pro Glu Ile Gly Val Val Gly Ala Asn Ser
50 55 60Lys Asp Asp Glu Ser Phe Phe Ser Cys Ala Gly Val Leu Ala Arg His65 70 7580Tyr Asn Glu Phe Phe Ser Asn Ser Arg Ala Asp Phe Ser Leu Ser Ala
85 90 95Tyr Leu Lys Glu Arg Gly Val Leu Gly Val Cys Gly Val Asp Thr Arg
100 105 110Ser Leu lle Lys Thr Leu Arg His His Gly Cys Leu Met Met Val Ala
115 120 125Ser Thr Ile Glu His Asp Lys Asn Lys Leu Glu Glu Ile Leu Lys Asn
130 135 140Ala Pro Lys Ile Ser His Ser Pro Leu Val Ser Ser Val Ser Thr Pro145 150 155 160Lys Ile Thr Thr His Gln Arg Ala Thr Phe Asp Phe Lys Thr Leu Asp
165 170 175Tvr Lvs Pro Phe Asp Glu Lys Thr Ser His Lys Ile Ile Ala Val Leu
180 185 190Asp Phe Gly Ala Lys Gly Asn Ile Leu Asn Glu Leu Gln Asn Val Gly
195 200 205Leu Lys Ala Leu Ile Tyr Pro His His Thr Lys Ala Ser Glu Leu Ile
210 215 220Lys Ala Tyr Glu Lys Lys Glu Ile Ser Gly Ile Phe Leu Ser Asn Gly225 230 235 240Pro Gly Asp Pro Leu Ser Leu Gln Gln Glu Ile Gly Glu Ile Lys Gln
245 250 255Leu Ile Asn Ala Lys Ile Pro Met Leu Gly Ile Cys Leu Gly His Gln
260 265 270Leu Leu Ser Ile Ala Gln Gly Tyr Pro Thr Tyr Lys Leu Lys Phe Gly
275 280 285His His Gly Ser Asn His Pro Val Lys Asn Leu Lys Thr Asn Ala Val
290 295 300Glu Ile Thr Ala Gln Asn His Asn Tyr Cys Val Pro Glu Asp Ile Glu305 310 315 320Glu lle Ala Ile Ile Thr His Arg Asn Leu Phe Asp Asn Thr Ile Glu
325 330 335Gly Val Arg Tyr Lys Asn Ala Pro Ile Ile Ser Val Gln His His Pro
340 345 350Glu Ser Ser Pro Gly Pro Lys Glu Ser His Tyr Ile Phe Lys Glu Phe
355 360 365Val Glu Leu Leu Lys Asp Phe
370 375
(2) Sequence 533 data:
(i) sequence characteristics:
(A) length: 2790bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 116...2656
(D) Other information:
(xi) Description of the sequence: sequence 533: TTCTCCTTTA ATTTTGGATG TTTAAAGTAT AATAAACTAT CTTTTTAAAA AAATAACTTA 60AAAGAGCTAT AAAATAGCCT TAAAATACGC GATAAAACAA CAAAAAGGAA TACCC ATG 118
Met
1GAT ATT CGC AAC GAA TTT TTA CAA TTT TTT CAA AAT AAA GGG CAT GCC 166Asp Ile Arg Asn Glu Phe Leu Gln Phe Phe Gln Asn Lys Gly His Ala
5 10 15GTT TAT CCT AGC ATG CCT TTA GTG CCT AAT GAC GCT ACC TTG CTT TTT 214Val Tyr Pro Ser Met Pro Leu Val Pro Asn Asp Ala Thr Leu Leu Phe
20 25 30ACC AAT GCC GGC ATG GTG CAA TTT AAA GAT ATT TTT ACC GGG ATT GTG 262Thr Asn Ala Gly Met Val Gln Phe Lys Asp Ile Phe Thr Gly Ile Val
35 40 45CCA CGC CCT AGC ATT CCT AGA GCG GCA AGC TCG CAA TTG TGC ATG CGC 310Pro Arg Pro Ser Ile Pro Arg Ala Ala Ser Ser Gln Leu Cys Met Arg50 55 60 65GCA GGC GGC AAG CAT AAC GAT TTG GAA AAT GTC GGT TAT ACC GCA AGG 358Ala Gly Gly Lys His Asn Asp Leu Glu Asn Val Gly Tyr Thr Ala Arg
70 75 80CAC CAC ACG CTT TTT GAA ATG CTA GGG AAT TTC TCT TTT GGG GAT TAT 406His His Thr Leu Phe Glu Met Leu Gly Asn Phe Ser Phe Gly Asp Tyr
85 90 95TTC AAA GAA GAA GCG ATC TTG TTT GCG TGG GAA TTT GTA ACC AAG AAT 454Phe Lys Glu Glu Ala Ile Leu Phe Ala Trp Glu Phe Val Thr Lys Asn
100 105 110TTA GGG TTT AAG CCT AAA GAT TTA TAC ATC AGC GTG CAT GAA AAG GAC 502Leu Gly Phe Lys Pro Lys Asp Leu Tyr Ile Ser Val His Glu Lys Asp
115 120 125GAT GAA GCC GTT AAA TTA TGG GAA AAG TTT GTG CCT GTT GAT AGG ATT 550Asp Glu Ala Val Lys Leu Trp Glu Lys Phe Val Pro Val Asp Arg Ile130 135 140 145AAA AAA ATG GGC GAT AAA GAT AAT TTT TGG CAA ATG GGC GAT AGC GGG 598Lys Lys Met Gly Asp Lys Asp Asn Phe Trp Gln Met Gly Asp Ser Gly
150 155 160CCT TGC GGG CCT TGC AGT GAAATT TAC ATT GAT CAG GGC GAA AAA CAC 646Pro Cys Gly Pro Cys Ser Glu Ile Tyr Ile Asp Gln Gly Glu Lys His
165 170 175TTT AAG GGG AGC GAG GAT TAT TTT GGG GGC GAG GGC GAT AGG TTT TTA 694Phe Lys Gly Ser Glu Asp Tyr Phe Gly Gly Glu Gly Asp Arg Phe Leu
180 185 190GAA ATT TGG AAT CTG GTG TTC ATG CAA TAC GAA CGC TCT AAT GAT GGC 742Glu Ile Trp Asn Leu Val Phe Met Gln Tyr Glu Arg Ser Asn Asp Gly
195 200 205GTT TTA TCC CCC TTG CCA AAG CCT AGC ATT GAT ACA GGC ATG GGA TTA 790Val Leu Ser Pro Leu Pro Lys Pro Ser Ile Asp Thr Gly Met Gly Leu210 215 220 225GAA AGG GTG CAA GCG CTA TTA GAA CAT AAG CTC AAT AAT TTT GAT TCT 838Glu Arg Val Gln Ala Leu Leu Glu His Lys Leu Asn Asn Phe Asp Ser
230 235 240TCA TTA TTT GCG CCC CTA ATG GAA GAA ATC AGC GAG CTT ACA AGC CTA 886Ser Leu Phe Ala Pro Leu Met Glu Glu Ile Ser Glu Leu Thr Ser Leu
245 250 255GAT TAT GCG AGC GAG TTC CAG CCA AGC TTT AGG GTA GTG GCC GAT CAC 934Asp Tyr Ala Ser Glu Phe Gln Pro Ser Phe Arg Val Val Ala Asp His
260 265 270GCA AGA GCG GTA GCA TTC TTG CTC GCT CAA GGG GTG CAT TTC AAT AAG 982Ala Arg Ala Val Ala Phe Leu Leu Ala Gln Gly Val His Phe Asn Lys
275 280 285GAA GGC CGT GGC TAT GTT TTA AGG CGC ATT TTA AGG CGA GCC TTA AGG 1030Glu Gly Arg Gly Tyr Val Leu Arg Arg Ile Leu Arg Arg Ala Leu Arg290 295 300 305CAT GGG TAT TTA ATG GGC TTG AAA GAA GCG TTT TTA TAC AAA GTC GTG 1078His Gly Tyr Leu Met Gly Leu Lys Glu Ala Phe Leu Tyr Lys Val Val
310 315 320GGC GTG GTG TGC GAG CAA TTT GCT AAC AGG CAT GCG TAT TTG AAA GAG 1126Gly Val Val Cys Glu Gln Phe Ala Asn Thr His Ala Tyr Leu Lys Glu
325 330 335TCT AAA GAA ATG GTG GTA AAA GAA TGT TTT GAA GAA GAA GAG CAC TTT 1174Ser Lys Glu Met Val Val Lys Glu Cys Phe Glu Glu Glu Glu His Phe
340 345 350TTA GAG ACT TTG GAA TCG GGC ATG GAA TTG TTT AAC TTG TCT TTA AAG 1222Leu Glu Thr Leu Glu Ser Gly Met Glu Leu Phe Asn Leu Ser Leu Lys
355 360 365CAT TTG AAT GAA AAT AAA ATC TTT GAT GGC AAG ATC GCT TTC AAG CTT 1270His Leu Asn Glu Asn Lys Ile Phe Asp Gly Lys Ile Ala Phe Lys Leu370 375 380 385TAT GAC ACT TTT GGT TTC CCT TTG GAT TTA ACA AAC GAC ATG TTA AGA 1318Tyr Asp Thr Phe Gly Phe Pro Leu Asp Leu Thr Asn Asp Met Leu Arg
390 395 400AGT CAT GGG GCG TGT GCG GAT ATG CAA GGC TTT GAA TTG TGC ATG CAA 1366Ser His Gly Ala Cys Ala Asp Met Gln Gly Phe Glu Leu Cys Met Gln
405 410 415GAG CAA GTG AAA CGC TCT AAA GCT TCA TGG AAA GGC AAA CAA AAC AAC 1414Glu Gln Val Lys Arg Ser Lys Ala Ser Trp Lys Gly Lys Gln Asn Asn
420 425 430GCC GAT TTT AGC GCT ATT TTA AAC GCT TAT GCA CCT AAT GTT TTT GTG 1462Ala Asp Phe Ser Ala Ile Leu Asn Ala Tyr Ala Pro Asn Val Phe Val
435 440 445GGG TAT GAA ACG ACA GAA TGT TCT GCT AAA GTT TTA GGG TTT TTT GAT 1510Gly Tyr Glu Thr Thr Glu Cys Ser Ala Lys Val Leu Gly Phe Phe Asp450 455 460465AGC GAT TTT AAA GAA ATA ACC GAT GCA AAT CCT AAC CAA GAA GTC TGG 1558Ser Asp Phe Lys Glu Ile Thr Asp Ala Asn Pro Asn Gln Glu Val Trp
470 475 480GTG TTG TTA GAA AAA ACC CCT TTT TAT GCA GAA GGT GGA GGG GCT ATA 1606Val Leu Leu Glu Lys Thr Pro Phe Tyr Ala Glu Gly Gly Gly Ala Ile
485 490 495GGC GAT AGG GGC GCG CTT TTT AAA GAC AAT GGA GAA GTG GCT ATC GTG 1654Gly Asp Arg Gly Ala Leu Phe Lys Asp Asn Gly Glu Val Ala Ile Val
500 505 510TTA GAT ACA AAA AAC TTT TTT GGG CTT AAT TTT TCA CTC CTT GAA ATC 1702Leu Asp Thr Lys Asn Phe Phe Gly Leu Asn Phe Ser Leu Leu Glu Ile
515 520 525AAA AAA GCG CTA AAA AAA GGC GAT CAA GTG ATC GCG CAA GTG AGC GAT 1750Lys Lys Ala Leu Lys Lys Gly Asp Gln Val Ile Ala Gln Val Ser Asp530 535 540 545GAG CGC TTT GAA ATC GCC AAA CAC CAT AGT GCG ACT CAT TTA TTG CAG 1798Glu Arg Phe Glu Ile Ala Lys His His Ser Ala Thr His Leu Leu Gln
550 555 560AGC GCT TTA AGA GAA GTT TTA GGC TCG CAT GTG AGT CAA GCG GGG AGT 1846Ser Ala Leu Arg Glu Val Leu Gly Ser His Val Ser Gln Ala Gly Ser
565 570 575TTA GTG GAA TCC AAG CGA TTG CGC TTT CAT TTC TCG CAT GCT AAA GCG 1894Leu Val Glu Ser Lys Arg Leu Arg Phe Asp Phe Ser His Ala Lys Ala
580 585 590CTC AAT GAT GAA GAG CTA GAA AAA GTA GAA GAT TTA GTC AAC GCT CAA 1942Leu Asn Asp Glu Glu Leu Glu Lys Val Glu Asp Leu Val Asn Ala Gln
595 600 605ATT TTC AAG CAC CTA AAT AGC CAG GTG GAG CAT ATG CCT TTA AAC CAA 1990Ile Phe Lys His Leu Asn Ser Gln Val Glu His Met Pro Leu Asn Gln610 615 620 625GCC AAA GAT AAG GGA GCG TTA GCG TTA TTC AGT GAA AAA TAC GCT GAA 2038Ala Lys Asp Lys Gly Ala Leu Ala Leu Phe Ser Glu Lys Tyr Ala Glu
630 635 640AAT GTG CGG GTG GTG AGC TTT AAA GAA GCG TCC ATT GAA TTG TGT GGG 2086Asn Val Arg Val Val Ser Phe Lys Glu Ala Ser Ile Glu Leu Cys Gly
645 650 655GGC ATT CAT GTG GAA AAT ACT GGG CTT ATT GGG GGG TTT AGG ATT GTA 2134Gly Ile His Val Glu Asn Thr Gly Leu Ile Gly Gly Phe Arg Ile Val
660 655 670AAA GAA AGC GGG GTG AGT AGT GGG GTC AGA CGC ATT GAA GCG GTG TGC 2182Lys Glu Ser Gly Val Ser Ser Gly Val Arg Arg Ile Glu Ala Val Cys
675 680 685GGG AAA GCC TTT TAC CAA CTG GCT AAA GAA GAA AAT AAA GAG CTT AAA 2230Gly Lys Ala Phe Tyr Gln Leu Ala Lys Glu Glu Asn Lys Glu Leu Lys690 695 700 705AAC GCT AAG ACT TTA TTG AAA AAT AAC GAT GTG ATC GCC GGT ATC AAT 2278Asn Ala Lys Thr Leu Leu Lys Asn Asn Asp Val Ile Ala Gly Ile Asn
710 715 720AAG CTT AAA GAG AGC GTG AAA AAC AGC CAA AAA GCC CCC GTT TCT ATG 2326Lys Leu Lys Glu Ser Val Lys Asn Ser Gln Lys Ala Pro Val Ser Met
725 730 735GAT TTA CCG GTT GAA AAA ATC CAT GGC GTG AAT TTG GTG GTG GGC GTA 2374Asp Leu Pro Val Glu Lys Ile His Gly Val Asn Leu Val Val Gly Val
740 745 750GTG GAA CAA GGC GAC ATT AAA GAA ATG ATT GAC CGA TTG AAA AGT AAG 2422Val Glu Gln Gly Asp Ile Lys Glu Met IleAsp Arg Leu Lys Ser Lys
755 760 765CAT GAA AGA TTG CTC GCT ATG GTG TTT AAA AAA GAA AAT GAG CGA ATC 2470His Glu Arg Leu Leu Ala Met Val Phe Lys Lys Glu Asn Glu Arg Ile770 775 780 785ACT CTC GCA TGC GGG GTG AAA AAC GCG CCC ATA AAA GCG AAT GTG TGG 2518Thr Leu Ala Cys Gly Val Lys Asn Ala Pro Ile Lys Ala Asn Val Trp
790 795 800GCT AAT GAA GTG GCG CAA ATT TTA GGG GGC AAA GGG GGC GGG AGA GGT 2566Ala Asn Glu Val Ala Gln Ile Leu Gly Gly Lys Gly Gly Gly Arg Gly
805 810 815GAT TTT GCG AGC GCT GGA GGC AAG GAT ATT GAA AAT TTG CAA GCC GCA 2614Asp Phe Ala Ser Ala Gly Gly Lys Asp Ile Glu Asn Leu Gln Ala Ala
820 825 830CTC AAT TTA GCG AAA AAT ACC GCT CTT AAA GCT TTA GAG GGA TAGCATGGA 2665Leu Asn Leu Ala Lys Asn Thr Ala Leu Lys Ala Leu Glu Gly
835 840 845GCTTATTTTA GGCTCTCAAT CCAGCACTAG GGCGAATCTC TTAAAAGAGC ATGGGATTAA 2725GTTTGAACAA AAAGCGCTCT ATTTTGATGA AGAAAGCCTA AAAACCACAG ACCCTAGGGA 2785GTTTG 2790
(2) Sequence 534 data:
(i) sequence characteristics:
(A) length: 847 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 534: met Asp Ile Arg Asn GluPhe Leu Gln Phe Phe Gln Asn Lys Gly His 151015 Ala Val Tyr Pro Ser Met Pro Leu Val Pro Asn Asp Ala Thr Leu Leu
20 25 30Phe Thr Asn Ala Gly Met Val Gln Phe Lys Asp Ile Phe Thr Gly Ile
35 40 45Val Pro Arg Pro Ser Ile Pro Arg Ala Ala Ser Ser Gln Leu Cys Met
50 55 60Arg Ala Gly Gly Lys His Asn Asp Leu Glu Asn Val Gly Tyr Thr Ala65 70 75 80Arg His His Thr Leu Phe Glu Met Leu Gly Asn Phe Ser Phe Gly Asp
85 90 95Tyr Phe Lys Glu Glu Ala Ile Leu Phe Ala Trp Glu Phe Val Thr Lys
100 105 110Asn Leu Gly Phe Lys Pro Lys Asp Leu Tyr Ile Ser Val His Glu Lys
115 120 125Asp Asp Glu Ala Val Lys Leu Trp Glu Lys Phe Val Pro Val Asp Arg
130 135 140Ile Lys Lys Met Gly Asp Lys Asp Asn Phe Trp Gln Met Gly Asp Ser145 150 155 160Gly Pro Cys Gly Pro Cys Ser Glu Ile Tyr Ile Asp Gln Gly Glu Lys
165 170 175His Phe Lys Gly Ser Glu Asp Tyr Phe Gly Gly Glu Gly Asp Arg Phe
180 185 190Leu Glu Ile Trp Asn Leu Val Phe Met Gln Tyr Glu Arg Ser Asn Asp
195 200 205Gly Val Leu Ser Pro Leu Pro Lys Pro Ser Ile Asp Thr Gly Met Gly
210 215 220Leu Glu Arg Val Gln Ala Leu Leu Glu His Lys Leu Asn Asn Phe Asp225 230 235 240Ser Ser Leu Phe Ala Pro Leu Met Glu Glu Ile Ser Glu Leu Thr Ser
245 250 255Leu Asp Tyr Ala Ser Glu Phe Gln Pro Ser Phe Arg Val Val Ala Asp
260 265 270His Ala Arg Ala Val Ala Phe Leu Leu Ala Gln Gly Val His Phe Asn
275 280 285Lys Glu Gly Arg Gly Tyr Val Leu Arg Arg Ile Leu Arg Arg Ala Leu
290 295 300Arg His Gly Tyr Leu Met Gly Leu Lys Glu Ala Phe Leu Tyr Lys Val305 310 315 320Val Gly Val Val Cys Glu Gln Phe Ala Asn Thr His Ala Tyr Leu Lys
325 330 335Glu Ser Lys Glu Met Val Val Lys Glu Cys Phe Glu Glu Glu Glu His
340 345 350Phe Leu Glu Thr Leu Glu Ser Gly Met Glu Leu Phe Asn Leu Ser Leu
355 360 365Lys His Leu Asn Glu Asn Lys Ile Phe Asp Gly Lys Ile Ala Phe Lys
370 375 380Leu Tyr Asp Thr Phe Gly Phe Pro Leu Asp Leu Thr Asn Asp Met Leu385 390 395 400Arg Ser His Gly Ala Cys Ala Asp Met Gln Gly Phe Glu Leu Cys Met
405 410 415Gln Glu Gln Val Lys Arg Ser Lys Ala Ser Trp Lys Gly Lys Gln Asn
420 425 430Asn Ala Asp Phe Ser Ala Ile Leu Asn Ala Tyr Ala Pro Asn Val Phe
435 440 445Val Gly Tyr Glu Thr Thr Glu Cys Ser Ala Lys Val Leu Gly Phe Phe
450 455 460Asp Ser Asp Phe Lys Glu Ile Thr Asp Ala Asn Pro Asn Gln Glu Val465 470 475 480Trp Val Leu Leu Glu Lys Thr Pro Phe Tyr Ala Glu Gly Gly Gly Ala
485 490 495Ile Gly Asp Arg Gly Ala Leu Phe Lys Asp Asn Gly Glu Val Ala Ile
500 505 510Val Leu Asp Thr Lys ASn Phe Phe Gly Leu Asn Phe Ser Leu Leu Glu
515 520 525Ile Lys Lys Ala Leu Lys Lys Gly Asp Gln Val Ile Ala Gln Val Ser
530 535 540Asp Glu Arg Phe Glu Ile Ala Lys His His Ser Ala Thr His Leu Leu545 550 555 560Gln Ser Ala Leu Arg Glu Val Leu Gly Ser His Val Ser Gln Ala Gly
565 570 575Ser Leu Val Glu Ser Lys Arg Leu Arg Phe Asp Phe Ser His Ala Lys
580 585 590Ala Leu Asn Asp Glu Glu Leu Glu Lys Val Glu Asp Leu Val Asn Ala
595 600 605Gln Ile Phe Lys His Leu Asn Ser Gln Val Glu His Met Pro Leu Asn
610 615 620Gln Ala Lys Asp Lys Gly Ala Leu Ala Leu Phe Ser Glu Lys Tyr Ala625 630 635 640Glu Asn Val Arg Val Val Ser Phe Lys Glu Ala Ser Ile Glu Leu Cys
645 650 655Gly Gly Ile His Val Glu Asn Thr Gly Leu Ile Gly Gly Phe Arg Ile
660 665 670Val Lys Glu Ser Gly Val Ser Ser Gly Val Arg Arg Ile Glu Ala Val
675 680 685Cys Gly Lys Ala Phe Tyr Gln Leu Ala Lys Glu Glu Asn Lys Glu Leu
690 695 700Lys Asn Ala Lys Thr Leu Leu Lys Asn Asn Asp Val Ile Ala Gly Ile705 710 715 720Asn Lys Leu Lys Glu Ser Val Lys Asn Ser Gln Lys Ala Pro Val Ser
725 730 735Met Asp Leu Pro Val Glu Lys Ile His Gly Val Asn Leu Val Val Gly
740 745 750Val Val Glu Gln Gly Asp Ile Lys Glu Met Ile Asp Arg Leu Lys Ser
755 760 765Lys His Glu Arg Leu Leu Ala Met Val Phe Lys Lys Glu Asn Glu Arg
770 775 780Ile Thr Leu Ala Cys Gly Val Lys Asn Ala Pro Ile Lys Ala Asn Val785 790 795 800Trp Ala Asn Glu Val Ala Gln Ile Leu Gly Gly Lys Gly Gly Gly Arg
805 810 815Gly Asp Phe Ala Ser Ala Gly Gly Lys Asp Ile Glu Asn Leu Gln Ala
820 825 830Ala Leu Asn Leu Ala Lys Asn Thr Ala Leu Lys Ala Leu Glu Gly
835 840 845
(2) Sequence 535 data:
(i) sequence characteristics:
(A) length: 720bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 100...636
(D) Other information:
(xi) Description of the sequence: sequence 535: TCGCACGCCA AAGAAAAACA CGAAAAAACC GAACACACGC ATTCTCACCA CACAGAGGAA 60GCAGAAAGCG TAGGATCTCA TAGCGAATAA GGGCTTATC ATG TTT AAT AAA GTG 114
Met Phe Asn Lys Val
1 5ATT ATG GTA GGG CGT TTG ACC AGG AAT GTG GAG TTG AAA TAT TTG CCT 162Ile Met Val Gly Arg Leu Thr Arg Asn Val Glu Leu Lys Tyr Leu Pro
10 15 20AGC GGT TCG GCT GCG GCT ACA ATA GGT TTA GCC ACA AGC AGG CGT TTT 210Ser Gly Ser Ala Ala Ala Thr Ile Gly Leu Ala Thr Ser Arg Arg Phe
25 30 35AAA AAA CAA GAC GGC ACG CTA GGC GAA GAG GTG TGC TTT ATA GAT GCG 258Lys Lys Gln Asp Gly Thr Leu Gly Glu Glu Val Cys Phe Ile Asp Ala
40 45 50CGT TTG TTT GGG CGA ACG GCT GAA ATC GCT AAC CAG TAT TTG AGC AAG 306Arg Leu Phe Gly Arg Thr Ala Glu Ile Ala Asn Gln Tyr Leu Ser Lys
55 60 65GGT TCA AGC GTT TTG ATA GAA GGG CGT TTG ACT TAT GAG AGT TGG ATG 354Gly Ser Ser Val Leu Ile Glu Gly Arg Leu Thr Tyr Glu Ser Trp Met70 75 80 85GAT CAA ACG GGC AAA AAA AAT TCC CGC CAC ACT ATC ACA GCG GAC TCG 402Asp Gln Thr Gly Lys Lys Asn Ser Arg His Thr Ile Thr Ala Asp Ser
90 95 100TTG CAA TTT ATG GAT AAA AAG TCA GAC AAT CCC CAA GCA AAC GCT ATG 450Leu Gln Phe Met Asp Lys Lys Ser Asp Asn Pro Gln AlaAsn Ala Met
105 110 115CAA GAT AGT ATA ATG CAT GAG AAT TCC AAC AAC GCT TAT CCC GCT AAT 498Gln Asp Ser Ile Met His Glu Asn Ser Asn Asn Ala Tyr Pro Ala Asn
120 125 130CAT AAC GCT CCC AGC CAA GAT CCT TTT AAC CAA GCT TAT GCG CAA AAC 546His Asn Ala Pro Ser Gln Asp Pro Phe Asn Gln Ala Tyr Ala Gln Asn
135 140 145GCT TAC GCT AAA GAG AAT TTA CAA GCA CAG CCG TCC AAG TAT CAA AAC 594Ala Tyr Ala Lys Glu Asn Leu Gln Ala Gln Pro Ser Lys Tyr Gln Asn150 155 160 165AGC GTG CCT GAA ATC AAT ATT GAT GAA GAA GAA ATC CCC TTT TAAGGGTTA 645Ser Val Pro Glu Ile Asn Ile Asp Glu Glu Glu Ile Pro Phe
170 175AAATTAAGGA GACATTATGG AAAGAAAACG CTATTCAAAA CGCTATTGCA AATACACTGA 705AGCTAAAATC AGCTT 720
(2) Sequence 536 data:
(i) sequence characteristics:
(A) length: 179 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 536: met Phe Asn Lys Val Ile Met Val Gly Arg Leu Thr Arg Asn Val Glu 151015 Leu Lys Tyr Leu Pro Ser Gly Ser Ala Ala Ala Thr Ile Gly Leu Ala
20 25 30Thr Ser Arg Arg Phe Lys Lys Gln Asp Gly Thr Leu Gly Glu Glu Val
3540 45Cys Phe Ile Asp Ala Arg Leu Phe Gly Arg Thr Ala Glu Ile Ala Asn
50 55 60Gln Tyr Leu Ser Lys Gly Ser Ser Val Leu Ile Glu Gly Arg Leu Thr65 70 75 80Tyr Glu Ser Trp Met Asp Gln Thr Gly Lys Lys Asn Ser Arg His Thr
85 90 95Ile Thr Ala Asp Ser Leu Gln Phe Met Asp Lys Lys Ser Asp Asn Pro
100 105 110Gln Ala Asn Ala Met Gln Asp Ser Ile Met His Glu Asn Ser Asn Asn
115 120 125Ala Tyr Pro Ala Asn His Asn Ala Pro Ser Gln Asp Pro Phe Asn Gln
130 135 140Ala Tyr Ala Gln Asn Ala Tyr Ala Lys Glu Asn Leu Gln Ala Gln Pro145 150 155 160Ser Lys Tyr Gln Asn Ser Val Pro Glu Ile Asn Ile Asp Glu Glu Glu
165 170 175Ile Pro Phe
(2) Sequence 537 data:
(i) sequence characteristics:
(A) length: 990bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 91...879
(D) Other information:
(xi) Description of the sequence: sequence 537: TCCAAAACGA TTGGGCTGAA ATTGAATTTT CTCACGAAAC AAAGGGCTAT GTGTTTTTAA 60AACTTTTAAA AAAGGCTGAA TGAAAGAATA ATG AAA TTA AAA TCT TTT GGG GTT 114
Met Lys Leu Lys Ser Phe Gly Val
1 5TTT GGA AAT CCC ATT AAG CAT TCC AAA TCG CCC TTA ATC CAT AAC GCT 162Phe Gly Asn Pro Ile Lys His Ser Lys Ser Pro Leu Ile His Asn Ala
10 15 20TGT TTT TTA ACT TTT CAA AAA GAA TTA AGG TTT TTG GGG CAT TAC CAC 210Cys Phe Leu Thr Phe Gln Lys Glu Leu Arg Phe Leu Gly His Tyr His25 30 35 40CCC ATA TTA CTC CCT TTA GAA AGC CAC ATC AAA AGC GAG TTT TTG CAT 258Pro Ile Leu Leu Pro Leu Glu Ser His Ile Lys Ser Glu Phe Leu His
45 50 55TTG GGA TTG AGT GGG GCT AAT GTA ACC TTA CCC TTT AAA GAA AGG GCG 306Leu Gly Leu Ser Gly Ala Asn Val Thr Leu Pro Phe Lys Glu Arg Ala
60 65 70TTT CAA GTT TGC GAT AAA ATC AAA GGT ATC GCG CTT GAA TGC GGA GCG 354Phe Gln Val Cys Asp Lys Ile Lys Gly Ile Ala Leu Glu Cys Gly Ala
75 80 85GTC AAT ACG CTT GTT TTA GAA AAT GAT GAG CTT GTG GGT TAC AAT ACC 402Val Asn Thr Leu Val Leu Glu Asn Asp Glu Leu Val Gly Tyr Asn Thr
90 95 100GAC GCT TTA GGG TTT TAT CTT TCT TTA AAG CAA AAA AAC TAT CAA AAC 450Asp Ala Leu Gly Phe Tyr Leu Ser Leu Lys Gln Lys Asn Tyr Gln Asn105 110 115 120GCT TTG ATT TTA GGA GCT GGG GGG AGC GCT AAA GCC CTA GCG TGT GAA 498Ala Leu Ile Leu Gly Ala Gly Gly Ser Ala Lys Ala Leu Ala Cys Glu
125 130 135TTG AAA AAA CAA GGC TTA CAA GTG AGC GTG TTG AAC CGC TCT TCT AGG 546Leu Lys Lys Gln Gly Leu Gln Val Ser Val Leu Asn Arg Ser Ser Arg
140 145 150GGA TTG GAT TTT TTC CAA CGC CTG GGC TGT GAT TGT TTT ATG GAG CCT 594Gly Leu Asp Phe Phe Gln Arg Leu Gly Cys Asp Cys Phe Met Glu Pro
155 160 165CCT AAA AGC GCT TTT GAT TTG ATT ATT AAC GCC ACT TCA GCG AGT TTG 642Pro Lys Ser Ala Phe Asp Leu Ile Ile Asn Ala Thr Ser Ala Ser Leu
170 175 180CAT AAC GAA TTG CCT TTG AAT AAA GAG GTT TTG AAA GGG TAT TTT AAA 690His Asn Glu Leu Pro Leu Asn Lys Glu Val Leu Lys Gly Tyr Phe Lys185 190 195 200GAG GGC AAG CTC GCT TAT GAT TTG GCG TAT GGG TTT TTA ACG CCC TTT 738Glu Gly Lys Leu Ala Tyr Asp Leu Ala Tyr Gly Phe Leu Thr Pro Phe
205 210 215TTG TCT TTA GCC AAA GAG TTA AAA ACC CCT TTT CAA GAC GGA AAA GAC 786Leu Ser Leu Ala Lys Glu Leu Lys Thr Pro Phe Gln Asp Gly Lys Asp
220 225 230ATG CTC ATC TAT CAA GCT GCT TTA AGT TTT GAA AAA TTC AGC GCT TCT 834Met Leu Ile Tyr Gln Ala Ala Leu Ser Phe Glu Lys Phe Ser Ala Ser
235 240 245CAA ATC CCT TAT TCA AAA GCG TTT GAA GTC ATG CGA AGT GTT TTT TGATG 884Gln Ile Pro Tyr Ser Lys Ala Phe Glu Val Met Arg Ser Val Phe
250 255 260CAAGGGTTTT TAAGAAGCCT GTTTTTTGGG GTTAAAAAGA TCCCTAAACC ATTCGCTCCT 944CTAGTAGAAA AGGGCGTTTT AAAAGAAGCG CTTGAATTGA AAAAGG 990
(2) Sequence 538 data:
(i) sequence characteristics:
(A) length: 263 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 538: met Lys Leu Lys Ser Phe Gly Val Phe Gly Asn Pro Ile Lys His Ser 151015 Lys Ser Pro Leu Ile His Asn Ala Cys Phe Leu Thr Phe Gln Lys Glu
20 25 30Leu Arg Phe Leu Gly His Tyr His Pro Ile Leu Leu Pro Leu Glu Ser
35 40 45His Ile Lys Ser Glu Phe Leu His Leu Gly Leu Ser Gly Ala Asn Val
50 55 60Thr Leu Pro Phe Lys Glu Arg Ala Phe Gln Val Cys Asp Lys Ile Lys65 70 75 80Gly Ile Ala Leu Glu Cys Gly Ala Val Asn Thr Leu Val Leu Glu Asn
85 90 95Asp Glu Leu Val Gly Tyr Asn Thr Asp Ala Leu Gly Phe Tyr Leu Ser
100 105 110Leu Lys Gln Lys Asn Tyr Gln Asn Ala Leu Ile Leu Gly Ala Gly Gly
115 120 125Ser Ala Lys Ala Leu Ala Cys Glu Leu Lys Lys Gln Gly Leu Gln Val
130 135 140Ser Val Leu Asn Arg Ser Ser Arg Gly Leu Asp Phe Phe Gln Arg Leu145 150 155 160Gly Cys Asp Cys Phe Met Glu Pro Pro Lys Ser Ala Phe Asp Leu Ile
165 170 175Ile Asn Ala Thr Ser Ala Ser Leu His Asn Glu Leu Pro Leu AsnLys
180 185 190Glu Val Leu Lys Gly Tyr Phe Lys Glu Gly Lys Leu Ala Tyr Asp Leu
195 200 205Ala Tyr Gly Phe Leu Thr Pro Phe Leu Ser Leu Ala Lys Glu Leu Lys
210 215 220Thr Pro Phe Gln Asp Gly Lys Asp Met Leu Ile Tyr Gln Ala Ala Leu225 230 235 240Ser Phe Glu Lys Phe Ser Ala Ser Gln Ile Pro Tyr Ser Lys Ala Phe
245 250 255Glu Val Met Arg Ser Val Phe
260
(2) Sequence 539 data:
(i) sequence characteristics:
(A) length: 1080bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 47...1033
(D) Other information:
(xi) Description of the sequence: sequence 539: TTTTTAGAGA GGGCGTGTTT GATAGCGTGG ATTTAAAGGA GCAAGC ATG AGC GCT 55
Met Ser Ala
1TAT ATC ATT GAA ACC CTG ATT AAA ATT TTG ATT TTA GTC GCT GTT TTT 103Tyr Ile Ile Glu Thr Leu Ile Lys Ile Leu Ile Leu Val Ala Val Phe
5 10 15TCG GCT TTA GGA GGCTTT GCC ACT TAT ATT GAA AGG AAA GTG TTA GCC 151Ser Ala Leu Gly Gly Phe Ala Thr Tyr Ile Glu Arg Lys Val Leu Ala20 25 30 35TAT TTC CAA CGC CGT TTA GGG CCT TGT TAT GTG GGG CCT TTT GGG CTT 199Tyr Phe Gln Arg Arg Leu Gly Pro Cys Tyr Val Gly Pro Phe Gly Leu
40 45 50TTG CAA GTC GCA GCA GAC GGC ATT AAG CTT TTC ACT AAA GAA GAC ATT 247Leu Gln Val Ala Ala Asp Gly Ile Lys Leu Phe Thr Lys Glu Asp Ile
55 60 65ATC CCT CAA GGC GCG AAC AAA TTC ATT TTC ACG CTA GCG CCC ATT ATT 295Ile Pro Gln Gly Ala Asn Lys Phe Ile Phe Thr Leu Ala Pro Ile Ile
70 75 80GCG ATG GTG AGT GCG TTT GTG TCC ATG GCG CCT ATC CCC TTT TTC CCT 343Ala Met Val Ser Ala Phe Val Ser Met Ala Pro Ile Pro Phe Phe Pro
85 90 95AAT TTC ACT CTG TTT GGC TAT GAG ATC AAG CCC CTT ATT TCT GAC ATC 391Asn Phe Thr Leu Phe Gly Tyr Glu Ile Lys Pro Leu Ile Sar Asp Ile100 105 110 115AAC ATT GGC TTT TTG TTT TTC TTA GCC GTG GGT TCG GCA GGG ATT TAT 439Asn Ile Gly Phe Leu Phe Phe Leu Ala Val Gly Ser Ala Gly Ile Tyr
120 125 130GCG CCT ATT TTA GCC GGG CTT GCC TCT AAT AAC AAA TAC TCT TTA ATT 487Ala Pro Ile Leu Ala Gly Leu Ala Ser Asn Asn Lys Tyr Ser Leu Ile
135 140 145GGC TCC GCA AGA GCG ACG ATC CAA CTG CTC AGC TTT GAA GTG GTC AGC 535Gly Ser Ala Arg Ala Thr Ile Gln Leu Leu Ser Phe Glu Val Val Ser
150 155 160ACT TTA ACC ATT CTA GCC CCC TTA ATG GTG GTA GGA TCG CTC TCT TTA 583Thr Leu Thr Ile Leu Ala Pro Leu Met Val Val Gly Ser Leu Ser Leu
165 170 175GTG GAA ATC AAT CAT TAC CAA AGC GGT GGG TTT TTA GAC TGG CTT GTG 631Val Glu Ile Asn His Tyr Gln Ser Gly Gly Phe Leu Asp Trp Leu Val180 185 190 195TTT AAG CAG CCT CTA GCG TTT GTT TTG TTT TTG ATC GCA AGT TAT GCC 679Phe Lys Gln Pro Leu Ala Phe Val Leu Phe Leu Ile Ala Ser Tyr Ala
200 205 210GAA TTG AAT CGA ACC CCC TTT GAC TTG CTA GAG CAT GAA GCC GAG ATC 727Glu Leu Asn Arg Thr Pro Phe Asp Leu Leu Glu His Glu Ala Glu Ile
215 220 225GTG GCG GGG TAT TGC ACC GAA TAC AGC GGC TTG AAA TGG GGC ATG TTC 775Val Ala Gly Tyr Cys Thr Glu Tyr Ser Gly Leu Lys Trp Gly Met Phe
230 235 240TTT TTA GCG GAA TAC GCG CAT TTA TTC GCT TTT TCT TTT GTG ATT TCT 823Phe Leu Ala Glu Tyr Ala His Leu Phe Ala Phe Ser Phe Val Ile Ser
245 250 255ATT GTG TTT TTT GGC GGG TTT AAC GCA TGG GGC TTT ATC CCT GGA GGC 871Ile Val Phe Phe Gly Gly Phe Asn Ala Trp Gly Phe Ile Pro Gly Gly260 265 270 275ATA GCG ATT TTG ATT AAA GCG GGC TTT TTT GTC TTT TTA TCC ATG TGG 919Ile Ala Ile Leu Ile Lys Ala Gly Phe Phe Val Phe Leu Ser Met Trp
280 285 290GTT AGA GCG ACT TAT CCG CAT GTG CGC CCA GAG CAA CTG ATG GAT ATG 967Val Arg Ala Thr Tyr Pro His Val Arg Pro Asp Gln Leu Met Asp Met
295 300 305TGC TGG AAA ATC ATG CTG CCT TTA GCG TTA TTG AAC ATT GTG CTA ACG 1015Cys Trp Lys Ile Met Leu Pro Leu Ala Leu Leu Asn Ile Val Leu Thr
310 315 320GGC ATT ATC ATT TTA ATT TAAAGGAGGT TTTATGGCCA AACAAGAATA CAAGCAAC 1071Gly Ile Ile Ile Leu Ile
325TTCCTAAAC 1080
(2) Sequence 540 data:
(i) sequence characteristics:
(A) length: 329 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 540: met Ser Ala Tyr Ile Ile Glu Thr Leu Ile Lys Ile Leu Ile Leu Val 151015 Ala Val Phe Ser Ala Leu Gly Gly Phe Ala Thr Tyr Ile Glu Arg Lys
20 25 30Val Leu Ala Tyr Phe Gln Arg Arg Leu Gly Pro Cys Tyr Val Gly Pro
35 40 45Phe Gly Leu Leu Gln Val Ala Ala Asp Gly Ile Lys Leu Phe Thr Lys
50 55 60Glu Asp Ile Ile Pro Gln Gly Ala Asn Lys Phe Ile Phe Thr Leu Ala65 70 75 80Pro Ile Ile Ala Met Val Ser Ala Phe Val Ser Met Ala Pro Ile Pro
85 90 95Phe Phe Pro Asn Phe Thr Leu Phe Gly Tyr Glu Ile Lys Pro Leu Ile
100 105 110Ser Asp Ile Asn Ile Gly Phe Leu Phe Phe Leu Ala Val Gly Ser Ala
115 120 125Gly Ile Tyr Ala Pro Ile Leu Ala Gly Leu Ala Ser Asn Asn Lys Tyr
130135 140Ser Leu Ile Gly Ser Ala Arg Ala Thr Ile Gln Leu Leu Ser Phe Glu145 150 155 160Val Val Ser Thr Leu Thr Ile Leu Ala Pro Leu Met Val Val Gly Ser
165 170 175Leu Ser Leu Val Glu Ile Asn His Tyr Gln Ser Gly Gly Phe Leu Asp
180 185 190Trp Leu Val Phe Lys Gln Pro Leu Ala Phe Val Leu Phe Leu Ile Ala
195 200 205Ser Tyr Ala Glu Leu Asn Arg Thr Pro Phe Asp Leu Leu Glu His Glu
210 215 220Ala Glu Ile Val Ala Gly Tyr Cys Thr Glu Tyr Ser Gly Leu Lys Trp225 230 235 240Gly Met Phe Phe Leu Ala Glu Tyr Ala His Leu Phe Ala Phe Ser Phe
245 250 255Val Ile Ser Ile Val Phe Phe Gly Gly Phe Asn Ala Trp Gly Phe Ile
260 265 270Pro Gly Gly Ile Ala Ile Leu Ile Lys Ala Gly Phe Phe Val Phe Leu
275 280 285Ser Met Trp Val Arg Ala Thr Tyr Pro His Val Arg Pro Asp Gln Leu
290 295 300Met Asp Met Cys Trp Lys Ile Met Leu Pro Leu Ala Leu Leu Asn Ile305 310 315 320Val Leu Thr Gly Ile IIe Ile Leu Ile
325
(2) Sequence 541 data:
(i) sequence characteristics:
(A) length: 1280bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 48...1226
(D) Other information:
(xi) Description of the sequence: sequence 541: TAAGGATAAA ATCAAGCGAT TAGCCCGAAT TTTAAGAGAG TATTAAG ATG AAT AAA 56
Met Asn Lys
1AAA GCG TAT TTT GGG GAG TTT GGA GGG AGT TTT GTT TCG GAG TTG TTA 104Lys Ala Tyr Phe Gly Glu Phe Gly Gly Ser Phe Val Ser Glu Leu Leu
5 10 15GTG CCT GCA TTA AGA GAA TTA GAA CAG GCG TTT GAT GCG TGT TTG AAA 152Val Pro Ala Leu Arg Glu Leu Glu Gln Ala Phe Asp Ala Cys Leu Lys20 25 30 35GAT GAA AAA TTC CAA AAA GAA TAT TTT CGT CTT TTA AAG GAT TTT GTG 200Asp Glu Lys Phe Gln Lys Glu Tyr Phe Arg Leu Leu Lys Asp Phe Val
40 45 50GGC CGT CCT AGC CCT TTA ACC TTG TGT CAA AAT ATC GTT TCT AAC CCT 248Gly Arg Pro Ser Pro Leu Thr Leu Cys Gln Asn Ile Val Ser Asn Pro
55 60 65AAA GTC AAG CTT TAT TTA AAA CGA GAG GAT TTA ATC CAT GGC GGG GCG 296Lys Val Lys Leu Tyr Leu Lys Arg Glu Asp Leu Ile His Gly Gly Ala
70 75 80CAT AAG ACT AAT CAA GCC TTA GGG CAA GCC CTT TTA GCG AAA AAA ATG 344His Lys Thr Asn Gln Ala Leu Gly Gln Ala Leu Leu Ala Lys Lys Met
85 90 95GGT AAA ACAAGG ATC ATC GCT GAA ACA GGC GCC GGT CAG CAT GGC GTG 392Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val100 105 110 115GCG ACG GCT ATC GCT TGC GCA TTA TTG AAC TTA AAA TGC GTG GTT TTT 440Ala Thr Ala Ile Ala Cys Ala Leu Leu Asn Leu Lys Cys Val Val Phe
120 125 130ATG GGA TCT AAA GAC ATC AAG CGC CAG GAA ATG AAT GTT TTT AGA ATG 488Met Gly Ser Lys Asp Ile Lys Arg Gln Glu Met Asn Val Phe Arg Met
135 140 145CAC TTA TTA GGC GCT GAA GTG AGA GAG GTT AAT TCA GGG AGC GCG ACG 536His Leu Leu Gly Ala Glu Val Arg Glu Val Asn Ser Gly Ser Ala Thr
150 155 160CTT AAA GAC GCT GTG AAT GAA GCC TTA AGA GAT TGG GCG AGC AGT TAC 584Leu Lys Asp Ala Val Asn Glu Ala Leu Arg Asp Trp Ala Ser Ser Tyr
165 170 175AAG GAC ACG CAT TAT TTG CTA GGC ACA GCC GCC GGG CCA CAC CCT TAC 632Lys Asp Thr His Tyr Leu Leu Gly Thr Ala Ala Gly Pro His Pro Tyr180 185 190 195CCC ACA ATG GTT AAA ACC TTT CAA AAA ATG ATA GGC GAT GAG GTT AAA 680Pro Thr Met Val Lys Thr Phe Gln Lys Met Ile Gly Asp Glu Val Lys
200 205 210AGC CAG ATT TTA GAA AAA GAA AAC CGC TTG CCT GAT TAT GTG ATC GCA 728Ser Gln Ile Leu Glu Lys Glu Asn Arg Leu Pro Asp Tyr Val Ile Ala
215 220 225TGC GTT GGA GGG GGG TCT AAC GCT ATA GGG ATA TTC AGC GCA TTT TTA 776Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Ile Phe Ser Ala Phe Leu
230 235 240AAC GAC AAA GAA GTT AAA CTC ATA GGC GTA GAG CCG GCG GGT TTA GGG 824Asn AspLys Glu Val Lys Leu Ile Gly Val Glu Pro Ala Gly Leu Gly
245 250 255CTA GAA ACC AAT AAG CAT GGG GCG ACT TTG AAT AAG GGG CGT GTG GGG 872Leu Glu Thr Asn Lys His Gly Ala Thr Leu Asn Lys Gly Arg Val Gly260 265 270 275ATT TTG CAT GGG AAT AAA ACC TAT CTT TTA CAA GAT GAT GAA GGC CAG 920Ile Leu His Gly Asn Lys Thr Tyr Leu Leu Gln Asp Asp Glu Gly Gln
280 285 290ATT GCA GAA AGC CAT AGC ATT AGC GCC GGG CTT GAT TAT CCA GGA GTG 968Ile Ala Glu Ser His Ser Ile Ser Ala Gly Leu Asp Tyr Pro Gly Val
295 300 305GGG CCA GAA CAC AGC TAT TTA AAA GAA AGT GGG CGT GCG GTT TAT GAA 1016Gly Pro Glu His Ser Tyr Leu Lys Glu Ser Gly Arg Ala Val Tyr Glu
310 315 320AGC GCA AGC GAT GCT GAA GCG CTA GAA GCC TTC AAG TTG TTG TGC CAA 1064Ser Ala Ser Asp Ala Glu Ala Leu Glu Ala Phe Lys Leu Leu Cys Gln
325 330 335AAA GAA GGC ATT ATC CCA GCG CTA GAA AGC TCA CAC GCC TTA GCG TAT 1112Lys Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr340 345 350 355GCC TTA AAG CTC GCT CAA AAA TGC GAA GAA GAA AGC ATC ATC GTA GTG 1160Ala Leu Lys Leu Ala Gln Lys Cys Glu Glu Glu Ser Ile Ile Val Val
360 365 370AAT TTA AGC GGC AGA GGG GAT AAG GAT TTA AGC ACC GTT TAT AAC GCT 1208Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Ser Thr Val Tyr Asn Ala
375 380 385TTA AAA GGA GGT TTA AAA TGAGGTATCA AAACATGTTT GAAACCTTAA AAAAACAC 1264Leu Lys Gly Gly Leu Lys
390GAAAAAATGG CGTTTA1280
(2) Sequence 542 data:
(i) sequence characteristics:
(A) length: 393 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 542: met Asn Lys Lys Ala Tyr Phe Gly Glu Phe Gly Gly Ser Phe Val Ser 151015 Glu Leu Leu Val Pro Ala Leu Arg Glu Leu Glu Gln Ala Phe Asp Ala
20 25 30Cys Leu Lys Asp Glu Lys Phe Gln Lys Glu Tyr Phe Arg Leu Leu Lys
35 40 45Asp Phe Val Gly Arg Pro Ser Pro Leu Thr Leu Cys Gln Asn Ile Val
50 55 60Ser Asn Pro Lys Val Lys Leu Tyr Leu Lys Arg Glu Asp Leu Ile His65 70 75 80Gly Gly Ala His Lys Thr Asn Gln Ala Leu Gly Gln Ala Leu Leu Ala
85 90 95Lys Lys Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln
100 105 110His Gly Val Ala Thr Ala Ile Ala Cys Ala Leu Leu Asn Leu Lys Cys
115 120 125Val Val Phe Met Gly Ser Lys Asp Ile Lys Arg Gln Glu Met Asn Val
130 135 140Phe Arg Met His Leu Leu Gly Ala Glu Val Arg Glu Val Asn Ser Gly145 150 155 160Ser Ala Thr Leu Lys Asp Ala Val Asn Glu Ala Leu Arg Asp Trp Ala
165 170 175Ser Ser Tyr Lys Asp Thr His Tyr Leu Leu Gly Thr Ala Ala Gly Pro
180 185 190His Pro Tyr Pro Thr Met Val Lys Thr Phe Gln Lys Met Ile Gly Asp
195 200 205Glu Val Lys Ser Gln Ile Leu Glu Lys Glu Asn Arg Leu Pro Asp Tyr
210 215 220Val Ile Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Ile Phe Ser225 230 235 240Ala Phe Leu Asn Asp Lys Glu Val Lys Leu Ile Gly Val Glu Pro Ala
245 250 255Gly Leu Gly Leu Glu Thr Asn Lys His Gly Ala Thr Leu Asn Lys Gly
260 265 270Arg Val Gly Ile Leu His Gly Asn Lys Thr Tyr Leu Leu Gln Asp Asp
275 280 285Glu Gly Gln Ile Ala Glu Ser His Ser Ile Ser Ala Gly Leu Asp Tyr
290 295 300Pro Gly Val Gly Pro Glu His Ser Tyr Leu Lys Glu Ser Gly Arg Ala305 310 315 320Val Tyr Glu Ser Ala Ser Asp Ala Glu Ala Leu Glu Ala Phe Lys Leu
325 330 335Leu Cys Gln Lys Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala
340 345 350Leu Ala Tyr Ala Leu Lys Leu Ala Gln Lys Cys Glu Glu Glu Ser Ile
355 360 365Ile Val Val Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Ser Thr Val
370375 380Tyr Asn Ala Leu Lys Gly Gly Leu Lys385 390
(2) Sequence 543 data:
(i) sequence characteristics:
(A) length: 559bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...513
(D) Other information:
(xi) Description of the sequence: sequence 543: CAGGTAGCTT TGGGCGAGAA AGGAGAGAGC ATG AAT GTC AAA AAT CGT TTG AGC 54
Met Asn Val Lys Asn Arg Leu Ser
1 5GAT TGG GAA TAT CAA TGG GCA GTG GCT CTA GTC TAT ACG ATA TGT ATC 102Asp Trp Glu Tyr Gln Trp Ala Val Ala Leu Val Tyr Thr Ile Cys Ile
10 15 20TCC ATA AAC GCT AGG ATT TTT TAT GAC ATA GAT GGT TCA GCT AGC GAT 150Ser Ile Asn Ala Arg Ile Phe Tyr Asp Ile Asp Gly Ser Ala Ser Asp25 30 35 40TCG ATT TTT GAC CCT AAA AAT AGC TAT TAT ATG TGG CTA GTG GGT CTA 198Ser Ile Phe Asp Pro Lys Asn Ser Tyr Tyr Met Trp Leu Val Gly Leu
45 50 55ATA GCG GCT TTG TTG TCT AAC CTT TTA TTT GAC CCA CGA GGT AGG GAT 246Ile Ala Ala Leu Leu Ser Asn Leu Leu Phe Asp Pro Arg Gly Arg Asp
60 65 70TGT TAT AAA TCT TTC CAA GTA AGA TACCCT AGG TTT GTC AAA GCC ATT 294Cys Tyr Lys Ser Phe Gln Val Arg Tyr Pro Arg Phe Leu Lys Ala Ile
75 80 85TTT AAG GCT AGG TTT TTT GGC GCG TTT TAT AAC GCT GTG TTA GGA TCA 342Phe Lys Ala Arg Phe Phe Gly Ala Phe Tyr Asn Ala Val Leu Gly Ser
90 95 100AGG CTA AGG GAT TTT TAT GTG ATG CTT TTA ACG ATA CCC TTT ATT GCC 390Arg Leu Arg Asp Phe Tyr Val Met Leu Leu Thr Ile Pro Phe Ile Ala105 110 115 120GCT ATC CAT GAG GTT TCG GCG TAT TAC GGG CAT CCT AGC AAC TTC CTT 438Ala Ile His Glu Val Ser Ala Tyr Tyr Gly His Pro Ser Asn Phe Leu
125 130 135ATA GAG GGT TTG GTC ATT CTT GGC CTT GTG TGT GTT TTT GGG ATT TGT 486Ile Glu Gly Leu Val Ile Leu Gly Leu Val Cys Val Phe Gly Ile Cys
140 145 150TCT AGG CTT TGC GCT AAA TTA GGG TGG TGATTTAACT CAAATAGCAT TAAATGG 540Ser Arg Leu Cys Ala Lys Leu Gly Trp
155 160AGGGGGGAGT AAAAAATTA 559
(2) Sequence 544 data:
(i) sequence characteristics:
(A) length: 161 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 544: met Asn Val Lys Asn Arg Leu Ser Asp Trp Glu Tyr Gln Trp Ala Val 151015 Ala Leu Val Tyr Thr Ile Cys Ile Ser Ile Asn Ala Arg IlePhe Tyr
20 25 30Asp Ile Asp Gly Ser Ala Ser Asp Ser Ile Phe Asp Pro Lys Asn Ser
35 40 45Tyr Tyr Met Trp Leu Val Gly Leu Ile Ala Ala Leu Leu Ser Asn Leu
50 55 60Leu Phe Asp Pro Arg Gly Arg Asp Cys Tyr Lys Ser Phe Gln Val Arg65 70 75 80Tyr Pro Arg Phe Leu Lys Ala Ile Phe Lys Ala Arg Phe Phe Gly Ala
85 90 95Phe Tyr Asn Ala Val Leu Gly Ser Arg Leu Arg Asp Phe Tyr Val Met
100 105 110Leu Leu Thr Ile Pro Phe Ile Ala Ala Ile His Glu Val Ser Ala Tyr
115 120 125Tyr Gly His Pro Ser Asn Phe Leu Ile Glu Gly Leu Val Ile Leu Gly
130 135 140Leu Val Cys Val Phe Gly Ile Cys Ser Arg Leu Cys Ala Lys Leu Gly145 150 155 160Trp
(2) Sequence 545 data:
(i) sequence characteristics:
(A) length: 810bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 53...712
(D) Other information:
(xi) Description of the sequence: sequence 545: TGAGATCAAA CCCGTAGAAC TTGTCAAGGT AATTCTTGCG TAAGGAAATA GC ATG TTA 58
Met Leu
1ATA ACC ACC CAA CTA TCC AAA CGA TTT TAC GCC ACA CTC GCT CTT TCT 106Ile Thr Thr Gln Leu Ser Lys Arg Phe Tyr Ala Thr Leu Ala Leu Ser
5 10 15TGC GTG TTT TTA ACC ATC ACT AAC ATT CTT GTC AAA GGC TCG TTT ATC 154Cys Val Phe Leu Thr Ile Thr Asn Ile Leu Val Lys Gly Ser Phe Ile
20 25 30AAT CTT TTA GCA GGG CTT AGT GGG GTT TTG TAT GCG TTT TTT GCC GGA 202Asn Leu Leu Ala Gly Leu Ser Gly Val Leu Tyr Ala Phe Phe Ala Gly35 40 45 50GAA AGG CAA ACG ATT TGC TTT GTG TTT GGT CTT GTT TAT AAT TTG AGT 250Glu Arg Gln Thr Ile Cys Phe Val Phe Gly Leu Val Tyr Asn Leu Ser
55 60 65TAC GCT TAT GTC GCT TAT CAG TGG AAA TTA AAC GCT GAT GTG ATT TTA 298Tyr Ala Tyr Val Ala Tyr Gln Trp Lys Leu Asn Ala Asp Val Ile Leu
70 75 80TGC CTT TTT TTG TAT ATG CCA GTA ACG ATT TAT GGG CTG TTC GCA TGG 346Cys Leu Phe Leu Tyr Met Pro Val Thr Ile Tyr Gly Leu Phe Ala Trp
85 90 95AAA AAG ACA GAG CAG CAT GAA GGC GTT ATC AAG GCT CAA AAA CTT TCC 394Lys Lys Thr Glu Gln His Glu Gly Val Ile Lys Ala Gln Lys Leu Ser
100 105 110AAA AAT TGG CGT TTT ATA CTC ATT TTA GGC GTA GGG GTT TTA ACT TGT 442Lys Asn Trp Arg Phe Ile Leu Ile Leu Gly Val Gly Val Leu Thr Cys115 120 125 130GTG AGC GCT TTG TTT TTT AAA GAG ATT AAA ACGAAT TTT TTA TGG GCA 490Val Ser Ala Leu Phe Phe Lys Glu Ile Lys Thr Asn Phe Leu Trp Ala
135 140 145GAG AGT TTT AAT TTC GTC ATC TTT ATT ATT GCT TTT ATT TTA CAG GTT 538Glu Ser Phe Asn Phe Val Ile Phe Ile Ile Ala Phe Ile Leu Gln Val
150 155 160TTG CGC TAT ATA GAA AAT TAT GCG CTA GTA ACT TTG GGG AAT ATC GTA 586Leu Arg Tyr Ile Glu Asn Tyr Ala Leu Val Thr Leu Gly Asn Ile Val
165 170 175TCC ATT ATC GTG TGG TTT TGT ATT TTT CAA ATT TCT ACA GAG AGC TTG 634Ser Ile Ile Val Trp Phe Cys Ile Phe Gln Ile Ser Thr Glu Ser Leu
180 185 190GTG CAA CTC TTC ACA ACG ATC CTA TAC CTT TTT ATT GGC TTG TAT TAT 682Val Gln Leu Phe Thr Thr Ile Leu Tyr Leu Phe Ile Gly Leu Tyr Tyr195 200 205 210TTT AAC CGG TGG AAT AAG TCA TGC AAG CAG TGATTTTAGC GAATGGGGAG TTT 735Phe Asn Arg Trp Asn Lys Ser Cys Lys Gln
215 220CCTAAATCTC AAAAATGCTT AGACCTTTTA AAAAACGCTC CCTTTTTAAT CGCATGCGAT 795GGGGCTGTTA CCTCA 810
(2) Data for sequence 546:
(i) sequence characteristics:
(A) length: 220 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 546: met Leu Ile Thr Thr Gln Leu Ser Lys Arg Phe Tyr Ala Thr Leu Ala 151015 Leu Ser Cys Val Phe Leu Thr Ile Thr Asn Ile Leu Val Lys Gly Ser
20 25 30Phe Ile Asn Leu Leu Ala Gly Leu Ser Gly Val Leu Tyr Ala Phe Phe
35 40 45Ala Gly Glu Arg Gln Thr Ile Cys Phe Val Phe Gly Leu Val Tyr Asn
50 55 60Leu Ser Tyr Ala Tyr Val Ala Tyr Gln Trp Lys Leu Asn Ala Asp Val65 70 75 80Ile Leu Cys Leu Phe Leu Tyr Met Pro Val Thr Ile Tyr Gly Leu Phe
85 90 95Ala Trp Lys Lys Thr Glu Gln His Glu Gly Val Ile Lys Ala Gln Lys
100 105 110Leu Ser Lys Asn Trp Arg Phe Ile Leu Ile Leu Gly Val Gly Val Leu
115 120 125Thr Cys Val Ser Ala Leu Phe Phe Lys Glu Ile Lys Thr Asn Phe Leu
130 135 140Trp Ala Glu Ser Phe Asn Phe Val Ile Phe Ile Ile Ala Phe Ile Leu145 150 155 160Gln Val Leu Arg Tyr Ile Glu Asn Tyr Ala Leu Val Thr Leu Gly Asn
165 170 175Ile Val Ser Ile Ile Val Trp Phe Cys Ile Phe Gln Ile Ser Thr Glu
180 185 190Ser Leu Val Gln Leu Phe Thr Thr Ile Leu Tyr Leu Phe Ile Gly Leu
195 200 205Tyr Tyr Phe Asn Arg Trp Asn Lys Ser Cys Lys Gln
210 215 220
(2) Sequence 547 data:
(i) sequence characteristics:
(A) length: 451bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...398
(D) Other information:
(xi) Description of the sequence: sequence 547: AGTTTAAAGA AAAGATTAGA AAAATTAGAA GATAAAGGAG GTAACGACTG ATG AGA 56
Met Arg
1CAC AAA CAC GGA TAC CGC AAG CTT GGG AGA ACC AGC TCG CAC AGA AAG 104His Lys His Gly Tyr Arg Lys Leu Gly Arg Thr Ser Ser His Arg Lys
5 10 15GCG TTA TTA AAG AAT TTA GCG ATC GCT TTG ATT GAG CAT AAC AAA ATT 152Ala Leu Leu Lys Asn Leu Ala Ile Ala Leu Ile Glu His Asn Lys Ile
20 25 30GAA ACA GGG ATT TAT AAG GCT AAG GAA TTG CGC AGT TAC ATT GAG AAA 200Glu Thr Gly Ile Tyr Lys Ala Lys Glu Leu Arg Ser Tyr Ile Glu Lys35 40 45 50TTG ACG ACA GCG GCT CGT GTG GGC GAT TTT AAT GCG CAC CGC CAT GTT 248Leu Thr Thr Ala Ala Arg Val Gly Asp Phe Asn Ala His Arg His Val
55 60 65TTT GCA TAT TTG CAA AAC AAA GAA GCC ACC CAC AAG CTT GTA ACT GAA 296Phe Ala Tyr Leu Gln Asn Lys Glu Ala Thr His Lys Leu Val Thr Glu
70 75 80ATC GCG CCC AAA TAC GCG CAA AGG AAT GGC GGA TAC ACC AGG ATC CAA 344Ile Ala Pro Lys Tyr Ala Gln Arg Asn Gly Gly Tyr Thr Arg Ile Gln
85 90 95CGC ACC ACT TTT AGA AGA GGG GAC GCT TCC ACT CTA GCC ACC ATT GAA 392Arg Thr Thr Phe Arg Arg Gly Asp Ala Ser Thr Leu Ala Thr Ile Glu
100 105 110TTT GTA TGAAATTTGA TGAACTGCTA GCCAAGATTT AGTCTTGGTT GGTGGTTATC GC 450Phe Val115T 451
(2) Sequence 548 data:
(i) sequence characteristics:
(A) length: 116 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 548: met Arg His Lys His Gly Tyr Arg Lys Leu Gly Arg Thr Ser Ser His 151015 Arg Lys Ala Leu Leu Lys Asn Leu Ala Ile Ala Leu Ile Glu His Asn
20 25 30Lys Ile Glu Thr Gly Ile Tyr Lys Ala Lys Glu Leu Arg Ser Tyr Ile
35 40 45Glu Lys Leu Thr Thr Ala Ala Arg Val Gly Asp Phe Asn Ala His Arg
50 55 60His Val Phe Ala Tyr Leu Gln Asn Lys Glu Ala Thr His Lys Leu Val65 70 75 80Thr Glu Ile Ala Pro Lys Tyr Ala Gln Arg Asn Gly Gly Tyr Thr Arg
85 90 95Ile Gln Arg Thr Thr Phe Arg Arg Gly Asp Ala Ser Thr Leu Ala Thr
100 105 110Ile Glu Phe Val
115
(2) Sequence 549 data:
(i) sequence characteristics:
(A) length: 1204bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 36...1142
(D) Other information:
(xi) Description of the sequence: sequence 549: AAAATAAGCG TTTTGATGCC ATTTTTGGAG CGATC GTG GAA TTG AGT TAT TAT 53
Val Glu Leu Ser Tyr Tyr
1 5GAA ATT TTA GAA GTG GAA AAA CAC AGC AAC CAA GAG ACC ATT AAA AAG 101Glu Ile Leu Glu Val Glu Lys His Ser Asn Gln Glu Thr Ile Lys Lys
10 15 20TCT TAC AGA AAG CTG GCT TTA AAA TAC CAC CCA GAC AGA AAC GCC GGC 149Ser Tyr Arg Lys Leu Ala Leu Lys Tyr His Pro Asp Arg Asn Ala Gly
25 30 35GAT AAA GAA GCC GAA GAA AAA TTC AAG CTC ATC AAT GAA GCC TAT GGG 197Asp Lys Glu Ala Glu Glu Lys Phe Lys Leu Ile Asn Glu Ala Tyr Gly
40 45 50GTG TTA AGC GAT GAA AAG AAG CGG GCC TTA TAC GAC AGG TAT GGT AAA 245Val Leu Ser Asp Glu Lys Lys Arg Ala Leu Tyr Asp Arg Tyr Gly Lys55 6065 70AAA GGC TTA AAC CAA GCC GGC GCA AGC CAA GGC GAT TTT TCT GAT TTT 293Lys Gly Leu Asn Gln Ala Gly Ala Ser Gln Gly Asp Phe Ser Asp Phe
75 80 85TTT GAA GAT TTA GGC TCG TTT TTT GAA GAC GCT TTT GGG TTT GGC GCT 341Phe Glu Asp Leu Gly Ser Phe Phe Glu Asp Ala Phe Gly Phe Gly Ala
90 95 100AGG GGG AGT AAA AGG CAA AAA AGC TCT ATC GCA CCG GAT TAT TTG CAA 389Arg Gly Ser Lys Arg Gln Lys Ser Ser Ile Ala Pro Asp Tyr Leu Gln
105 110 115ACC CTT GAA TTG AGT TTC AAA GAA GCG GTT TTT GGC TGT AAA AAA ACC 437Thr Leu Glu Leu Ser Phe Lys Glu Ala Val Phe Gly Cys Lys Lys Thr
120 125 130ATT AAA GTC CAA TAC CAG AGC GTT TGT GAA AGT TGC GAT GGC ACG GGC 485Ile Lys Val Gln Tyr Gln Ser Val Cys Glu Ser Cys Asp Gly Thr Gly135 140 145 150GCT AAA GAC AAA GCC CTA GAG ACT TGC AAG CAA TGC AAT GGG CAG GGG 533Ala Lys Asp Lys Ala Leu Glu Thr Cys Lys Gln Cys Asn Gly Gln Gly
155 160 165CAG GTG TTT ATG CGT CAA GGT TTT ATG AGT TTT GCG CAA ACT TGT GGG 581Gln Val Phe Met Arg Gln Gly Phe Met Ser Phe Ala Gln Thr Cys Gly
170 175 180GCG TGT CAA GGC AAG GGC AAG ATC GTT AAA ACC CCA TGC CAA GCG TGC 629Ala Cys Gln Gly Lys Gly Lys Ile Val Lys Thr Pro Cys Gln Ala Cys
185 190 195AAG GGT AAA ACC TAT ATC CTT AAA GAT GAA GAA ATT GAT GCG ATA ATC 677Lys Gly Lys Thr Tyr Ile Leu Lys Asp Glu Glu Ile Asp Ala Ile Ile
200 205 210CCT GAG GGC ATT GAT GAT CAA AAC CGC ATG GTG CTT AAA AAT AAA GGC 725Pro Glu Gly Ile Asp Asp Gln Asn Arg Met Val Leu Lys Asn Lys Gly215 220 225 230AAT GAA TAC GAG AAG GGA AAA AGA GGG GAT TTG TAT TTA GAA GCG CAA 773Asn Glu Tyr Glu Lys Gly Lys Arg Gly Asp Leu Tyr Leu Glu Ala Gln
235 240 245GTC AAA GAA GAT GAG CAT TTC AAG CGC GAA GGC TGC GAT TTA TTC ATT 821Val Lys Glu Asp Glu His Phe Lys Arg Glu Gly Cys Asp Leu Phe Ile
250 255 260AAA GCG CCG GTG TTT TTC ACC ACT ATC GCT TTA GGG CAT ACG ATT AAA 869Lys Ala Pro Val Phe Phe Thr Thr Ile Ala Leu Gly His Thr Ile Lys
265 270 275GTG CCG TCT TTA AAA GGG GAC GAA CTG GAA TTA AAA ATC CCT AGA AAC 917Val Pro Ser Leu Lys Gly Asp Glu Leu Glu Leu Lys Ile Pro Arg Asn
280 285 290GCC AGA GAC AAG CAG ACT TTT GCG TTT AGA AAC GAG GGC GTG AAA CAC 965Ala Arg Asp Lys Gln Thr Phe Ala Phe Arg Asn Glu Gly Val Lys His295 300 305 310CCT GAA AGC TCT TAT AGA GGG AGT TTG ATC GTG GAA TTG CAA GTG ATT 1013Pro Glu Ser Ser Tyr Arg Gly Ser Leu Ile Val Glu Leu Gln Val Ile
315 320 325TAC CCT AAA AGT TTG AAT AAA GAG CAG CAA GAA TTG TTG GAA AAA TTG 1061Tyr Pro Lys Ser Leu Asn Lys Glu Gln Gln Glu Leu Leu Glu Lys Leu
330 335 340CAT GCG AGT TTT GGC TAT GAG GGC GAG CCG CAT AAA AGC GTT TTA GAA 1109His Ala Ser Phe Gly Tyr Glu Gly Glu Pro His Lys Ser Val Leu Glu
345 350 355ACC TGT ATT TCT AAA ATT AAA GAC TGG TTC AAA TAAAAGGTTG TTGATGCATG 1162Thr Cys Ile Ser Lys Ile Lys Asp TrpPhe Lys
360 365AGTTTCTAAA AGCTTTTAAA GACGCTTTCC CTCATACCAT TT 1204
(2) Sequence 550 data:
(i) sequence characteristics:
(A) length: 369 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 550: val Glu Leu Ser Tyr Tyr Glu Ile Leu Glu Val Glu Lys His Ser Asn 151015 Gln Glu Thr Ile Lys Lys Ser Tyr Arg Lys Leu Ala Leu Lys Tyr His
20 25 30Pro Asp Arg Asn Ala Gly Asp Lys Glu Ala Glu Glu Lys Phe Lys Leu
35 40 45Ile Asn Glu Ala Tyr Gly Val Leu Ser Asp Glu Lys Lys Arg Ala Leu
50 55 60Tyr Asp Arg Tyr Gly Lys Lys Gly Leu Asn Gln Ala Gly Ala Ser Gln65 70 75 80Gly Asp Phe Ser Asp Phe Phe Glu Asp Leu Gly Ser Phe Phe Glu Asp
85 90 95Ala Phe Gly Phe Gly Ala Arg Gly Ser Lys Arg Gln Lys Ser Ser Ile
100 105 110Ala Pro Asp Tyr Leu Gln Thr Leu Glu Leu Ser Phe Lys Glu Ala Val
115 120 125Phe Gly Cys Lys Lys Thr Ile Lys Val Gln Tyr Gln Ser Val Cys Glu
130 135 140Ser Cys Asp Gly Thr Gly Ala Lys Asp Lys Ala Leu Glu Thr Cys Lys145 150 155 160Gln Cys Asn Gly Gln Gly Gln Val Phe Met Arg Gln Gly Phe Met Ser
165 170 175Phe Ala Gln Thr Cys Gly Ala Cys Gln Gly Lys Gly Lys Ile Val Lys
180 185 190Thr Pro Cys Gln Ala Cys Lys Gly Lys Thr Tyr Ile Leu Lys Asp Glu
195 200 205Glu Ile Asp Ala Ile Ile Pro Glu Gly Ile Asp Asp Gln Asn Arg Met
210 215 220Val Leu Lys Asn Lys Gly Asn Glu Tyr Glu Lys Gly Lys Arg Gly Asp225 230 235 240Leu Tyr Leu Glu Ala Gln Val Lys Glu Asp Glu His Phe Lys Arg Glu
245 250 255Gly Cys Asp Leu Phe Ile Lys Ala Pro Val Phe Phe Thr Thr Ile Ala
260 265 270Leu Gly His Thr Ile Lys Val Pro Ser Leu Lys Gly Asp Glu Leu Glu
275 280 285Leu Lys Ile Pro Arg Asn Ala Arg Asp Lys Gln Thr Phe Ala Phe Arg
290 295 300Asn Glu Gly Val Lys His Pro Glu Ser Ser Tyr Arg Gly Ser Leu Ile305 310 315 320Val Glu Leu Gln Val Ile Tyr Pro Lys Ser Leu Asn Lys Glu Gln Gln
325 330 335Glu Leu Leu Glu Lys Leu His Ala Ser Phe Gly Tyr Glu Gly Glu Pro
340 345 350His Lys Ser Val Leu Glu Thr Cys Ile Ser Lys Ile Lys Asp Trp Phe
355 360 365Lys
(2) Sequence 551 data:
(i) sequence characteristics:
(A) length: 810bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 12...779
(D) Other information:
(xi) Description of the sequence: sequence 551: CGCATGGAGA A ATG AGG GTA ATG GCC AAA ATT GAA TTG TTA GCC AAA TTC 50
Met Arg Val Met Ala Lys Ile Glu Leu Leu Ala Lys Phe
1 5 10ACG CAA ATC GCG CTC CCT AAC AGC CAC CCT TTA TTG AAA AAA GTT TTA 98Thr Gln Ile Ala Leu Pro Asn Ser His Pro Leu Leu Lys Lys Val Leu
15 20 25AAC TAC GCC AAA AAG CAT TTC AGC CAG TGC CAC ATG CTC TCT TCA TCG 146Asn Tyr Ala Lys Lys His Phe Ser Gln Cys His Met Leu Ser Ser Ser30 35 40 45TTA CTC ATC TTA AAC GAC ACG GAA TGC TTT AAA AAA AAC TAC TTG CTT 194Leu Leu Ile Leu Asn Asp Thr Glu Cys Phe Lys Lys Asn Tyr Leu Leu
50 55 60AAT TGG GTC TAT CAT GCC CTT GAA TGC GTG CAT GAA AAA GAT ATT AGC 242Asn Trp Val Tyr His Ala Leu Glu Cys Val His Glu Lys Asp Ile Ser
65 70 75GCG CAT TCT TTA GAA GAG GTT TTA CAA AAA AGC CAC CTG CCC ATA CGC 290Ala His Ser Leu Glu Glu Val Leu Gln Lys Ser His Leu Pro Ile Arg
80 85 90ATC AAA ATC ATG GCT CAA AAC ACG CTT TTA GAA AAG ATA GAA GTG AAA 338Ile Lys Ile Met Ala Gln Asn Thr Leu Leu Glu Lys Ile Glu Val Lys
95 100 105GTT TTA ACC TTT GGG GCG GAA TAT GCG CTT TTT ATC ACC AAA CAC CCT 386Val Leu Thr Phe Gly Ala Glu Tyr Ala Leu Phe Ile Thr Lys His Pro110 115 120 125ATC GCC AAG CGG TTT TTA CGC CAA AAA TTT AGC GGC TGT GTG TTT TTA 434Ile Ala Lys Arg Phe Leu Arg Gln Lys Phe Ser Gly Cys Val Phe Leu
130 135 140GAA ACC CAA GAT GAA TTG CAT ATA AGA GGC GAT TCA GAG CGT TTT TGG 482Glu Thr Gln Asp Glu Leu His Ile Arg Gly Asp Ser Glu Arg Phe Trp
145 150 155GAA CTC ATT GTA ACG CTC AAT GAA AAT AGA ATC GTC CAT AAC GCA TGC 530Glu Leu Ile Val Thr Leu Asn Glu Asn Arg Ile Val His Asn Ala Cys
160 165 170TTA GAT TTC ATC TAC CCT AAT GGC TTT GGC AAG GAC AGC TAC ACC ACT 578Leu Asp Phe Ile Tyr Pro Asn Gly Phe Gly Lys Asp Ser Tyr Thr Thr
175 180 185ATG GCT GAA CGC AAA TTA AAA GAA TGC TAT AAA ACG CTA GGG TTT ATC 626Met Ala Glu Arg Lys Leu Lys Glu Cys Tyr Lys Thr Leu Gly Phe Ile190 195 200 205AAG CAT GAA GAT TTC AGC GAA GTC AAA AAG CGC TAT TTA GAA TTG GCT 674Lys His Glu Asp Phe Ser Glu Val Lys Lys Arg Tyr Leu Glu Leu Ala
210 215 220AAA ACC TAC CAC CCT GAT TTA TGC GAT CTC AAA GAA AAA AAG GCT CTT 722Lys Thr Tyr His Pro Asp Leu Cys Asp Leu Lys Glu Lys Lys Ala Leu
225 230 235TAT GCC AAA CGC TTC GCT ATC ATT CAA GAG GCG TAT CGC CAC ATT AAA 770Tyr Ala Lys Arg Phe Ala Ile Ile Gln Glu Ala Tyr Arg His Ile Lys
240 245 250AAA CAC GCC TAAACCCCTA AACTAGCCCT AATCGCGCTA G 810Lys His Ala
255
(2) Sequence 552 data:
(i) sequence characteristics:
(A) length: 256 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 552: met Arg Val Met Ala Lys Ile Glu Leu Leu Ala Lys Phe Thr Gln Ile 151015 Ala Leu Pro Asn Ser His Pro Leu Leu Lys Lys Val Leu Asn Tyr Ala
20 25 30Lys Lys His Phe Ser Gln Cys His Met Leu Ser Ser Ser Leu Leu Ile
35 40 45Leu Asn Asp Thr Glu Cys Phe Lys Lys Asn Tyr Leu Leu Asn Trp Val
50 55 60Tyr His Ala Leu Glu Cys Val His Glu Lys Asp Ile Ser Ala His Ser65 70 75 80Leu Glu Glu Val Leu Gln Lys Ser His Leu Pro Ile Arg Ile Lys Ile
85 90 95Met Ala Gln Asn Thr Leu Leu Glu Lys Ile Glu Val Lys Val Leu Thr
100 105 110Phe Gly Ala Glu Tyr Ala Leu Phe Ile Thr Lys His Pro Ile Ala Lys
115 120125Arg Phe Leu Arg Gln Lys Phe Ser Gly Cys Val Phe Leu Glu Thr Gln
130 135 140Asp Glu Leu His Ile Arg Gly Asp Ser Glu Arg Phe Trp Glu Leu Ile145 150 155 160Val Thr Leu Asn Glu Asn Arg Ile Val His Asn Ala Cys Leu Asp Phe
165 170 175Ile Tyr Pro Asn Gly Phe Gly Lys Asp Ser Tyr Thr Thr Met Ala Glu
180 185 190Arg Lys Leu Lys Glu Cys Tyr Lys Thr Leu Gly Phe Ile Lys His Glu
195 200 205Asp Phe Ser Glu Val Lys Lys Arg Tyr Leu Glu Leu Ala Lys Thr Tyr
210 215 220His Pro Asp Leu Cys Asp Leu Lys Glu Lys Lys Ala Leu Tyr Ala Lys225 230 235 240Arg Phe Ala Ile Ile Gln Glu Ala Tyr Arg His Ile Lys Lys His Ala
245 250 255
(2) Sequence 553 data:
(i) sequence characteristics:
(A) length: 900bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 59..778
(D) Other information:
(xi) Description of the sequence: sequence 553: CATGATGATT ATTATAAAAT CCTAACGCCG CATGAACAAA TAGGATGGGT CAAAAAAG 58ATG AAG TCA AAT AAA AAG TCC AAT CGT TTA AGA GCG ATT TAT AGA GCT 106Met Lys Ser Asn Lys Lys Ser Asn Arg Leu Arg Ala Ile Tyr Arg Ala 151015 TTA GTG ATC GCT ATA GGA CTA GCT GTT ATC ATC GTT TTC AAT TAC TTT 154Leu Val Ile Ala Ile Gly Leu Ala Val Ile Ile Val Phe Asn Tyr Phe
20 25 30AAC CGC AAA AAC AAT AAC GCC CGC TCC AGC CGT AGG GCT TGT TCG TGC 202Asn Arg Lys Asn Asn Asn Ala Arg Ser Ser Arg Arg Ala Cys Ser Cys
35 40 45TTT TTT TCC CTT ACC GGG GTT AAT TTA GAA AAA ATA GGC ACT TTT GAT 250Phe Phe Ser Leu Thr Gly Val Asn Leu Glu Lys Ile Gly Thr Phe Asp
50 55 60ACG GAC GCT AAA CTC ATT GTC TTA AAC CAC CAA AGC TTA CTA GAC ATC 298Thr Asp Ala Lys Leu Ile Val Leu Asn His Gln Ser Leu Leu Asp Ile65 70 75 80ATT TAT TTA GAA GCC TAC CAC CCT AGA AAT ATT TGC TGG ATC GCT AAA 346Ile Tyr Leu Glu Ala Tyr His Pro Arg Asn Ile Cys Trp Ile Ala Lys
85 90 95AAA GAG CTG GGC GAA ATC CCT TTT TAT GGG CAT GCC TTA ACG GAT ACC 394Lys Glu Leu Gly Glu lle Pro Phe Tyr Gly His Ala Leu Thr Asp Thr
100 105 110GGA ATG ATT TTA ATT GAC AGA GAG GAT AAA AAG GGG ATT GTG AGC CTT 442Gly Met Ile Leu Ile Asp Arg Glu Asp Lys Lys Gly Ile Val Ser Leu
115 120 125TTG AAA GCG TGT AAA GAA AAA TTA GAC CAA AAC CGC CCT TTA GTG ATT 490Leu Lys Ala Cys Lys Glu Lys Leu Asp Gln Asn Arg Pro Leu Val Ile
130 135 140TTC CCT GAA GGC ACT AGA GGC AAA GGA GGA GAA AAA TTC CTC CCT TTC 538Phe Pro Glu Gly Thr Arg Gly Lys Gly Gly Glu Lys Phe Leu Pro Phe145150 155 160AAG CAA GGG GCT AAA ATC ATC GCC GAA AAA TTC CAG CTC AAA ATC CAA 586Lys Gln Gly Ala Lys Ile Ile Ala Glu Lys Phe Gln Leu Lys Ile Gln
165 170 175CCC ATG GTG TTA ATC AAT TCC ATT AAA ATC TTT AAT TCC AAG CCT CTA 634Pro Met Val Leu Ile Asn Ser Ile Lys Ile Phe Asn Ser Lys Pro Leu
180 185 190GAA GCC TAT AAA GCG CGC ACC CGT TTA GTC ATG CTA GAA AGC TAT ACG 682Glu Ala Tyr Lys Ala Arg Thr Arg Leu Val Met Leu Glu Ser Tyr Thr
195 200 205CCT GAT TTT AAC TCG CCC ACC TGG TAT GAA GAA TTA CAA GAA CGC ATG 730Pro Asp Phe Asn Ser Pro Thr Trp Tyr Glu Glu Leu Gln Glu Arg Met
210 215 220CAA AAA GAG TAT TTA AAA CAC TAT CAT GAA TTA AAC CCT AGC GAA CAA TGA 781Gln Lys Glu Tyr Leu Lys His Tyr His Glu Leu Asn Pro Ser Glu Gln225 230 235 240AGCTTTTTGA CTACGCTCCT TTGAGTTTGG CTTGGCGGGA GTTTTTGCAA AGCGAATTTA 841AAAAGCCTTA TTTTTTAGAA ATAGAAAAAC GCTACCTAGA AGCCCTAAAA ATCCCTAAA 900
(2) Sequence 554 data:
(i) sequence characteristics:
(A) length: 240 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 554: met Lys Ser Asn Lys Lys Ser Asn Arg Leu Arg Ala Ile Tyr Arg Ala 151015 Leu Val Ile Ala Ile Gly Leu Ala Val Ile Ile Val Phe Asn Tyr Phe
20 25 30Asn Arg Lys Asn Asn Asn Ala Arg Ser Ser Arg Arg Ala Cys Ser Cys
35 40 45Phe Phe Ser Leu Thr Gly Val Asn Leu Glu Lys Ile Gly Thr Phe Asp
50 55 60Thr Asp Ala Lys Leu Ile Val Leu Asn His Gln Ser Leu Leu Asp Ile65 70 75 80Ile Tyr Leu Glu Ala Tyr His Pro Arg Asn Ile Cys Trp Ile Ala Lys
85 90 95Lys Glu Leu Gly Glu Ile Pro Phe Tyr Gly His Ala Leu Thr Asp Thr
100 105 110Gly Met Ile Leu Ile Asp Arg Glu Asp Lys Lys Gly Ile Val Ser Leu
115 120 125Leu Lys Ala Cys Lys Glu Lys Leu Asp Gln Asn Arg Pro Leu Val Ile
130 135 140Phe Pro Glu Gly Thr Arg Gly Lys Gly Gly Glu Lys Phe Leu Pro Phe145 150 155 160Lys Gln Gly Ala Lys Ile Ile Ala Glu Lys Phe Gln Leu Lys Ile Gln
165 170 175Pro Met Val Leu Ile Asn Ser Ile Lys Ile Phe Asn Ser Lys Pro Leu
180 185 190Glu Ala Tyr Lys Ala Arg Thr Arg Leu Val Met Leu Glu Ser Tyr Thr
195 200 205Pro Asp Phe Asn Ser Pro Thr Trp Tyr Glu Glu Leu Gln Glu Arg Met
210 215 220Gln Lys Glu Tyr Leu Lys His Tyr His Glu Leu Asn Pro Ser Glu Gln225 230 235 240
(2) Sequence 555 data:
(i) sequence characteristics:
(A) length: 990bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 40...858
(D) Other information:
(xi) Description of the sequence: sequence 555: GGCCAAACTC GCTTTAACTA AAATGATGGA GTTATCTTA ATG GAG ATT AGA ACC 54
Met Glu Ile Arg Thr
1 5TTT TTA GAA CGC GCT TTA AAA GAA GAT TTA GGG CAT GGG GAT TTG TTT 102Phe Leu Glu Arg Ala Leu Lys Glu Asp Leu Gly His Gly Asp Leu Phe
10 15 20GAA AGG GTG TTA GAA AAA GAT TTT AAG GCC ACA GCG TTT GTT AGG GCT 150Glu Arg Val Leu Glu Lys Asp Phe Lys Ala Thr Ala Phe Val Arg Ala
25 30 35AAA CAA GAG GGC GTG TTT TCA GGC GAA AAA TAC GCT TTA GAG TTG TTG 198Lys Gln Glu Gly Val Phe Ser Gly Glu Lys Tyr Ala Leu Glu Leu Leu
40 45 50GAA ATG ACC GGC ATT GAA TGC GTT CAA ACG ATT AAG GAT AAA GAA CGC 246Glu Met Thr Gly Ile Glu Cys Val Gln Thr Ile Lys Asp Lys Glu Arg
55 60 65TTC AAG CCT AAA GAC GCT TTA ATG GAA ATT AGG GGG GAT TTT AGC ATG 294Phe Lys Pro Lys Asp Ala Leu Met Glu Ile Arg Gly Asp Phe Ser Met70 7580 85CTT TTA AAG GTT GAG CGC ACC CTT TTA AAC CTT TTG CAA CAC AGC AGC 342Leu Leu Lys Val Glu Arg Thr Leu Leu Asn Leu Leu Gln His Ser Ser
90 95 100GGG ATT GCT ACT TTA ACG AGC CGT TTT GTA GAG GCT TTA AAT TCT CAT 390Gly Ile Ala Thr Leu Thr Ser Arg Phe Val Glu Ala Leu Asn Ser His
105 110 115AAA GTG CGT TTG TTG GAC ACG AGA AAA ACG AGA CCC CTT TTA AGG ATC 438Lys Val Arg Leu Leu Asp Thr Arg Lys Thr Arg Pro Leu Leu Arg Ile
120 125 130TTT GAA AAA TAT TCC GTG CTT AAT GGG GGA GCG AGC AAC CAC CGC TTA 486Phe Glu Lys Tyr Ser Val Leu Asn Gly Gly Ala Ser Asn His Arg Leu
135 140 145GGG CTA GAT GAC GCT TTA ATG CTT AAA GAC ACG CAT TTA AGG CAT GTG 534Gly Leu Asp Asp Ala Leu Met Leu Lys Asp Thr His Leu Arg His Val150 155 160 165AAA GAT CTC AAA AGC TTT TTA ACG CAT GCC AGA AAA AAC TTG CCT TTC 582Lys Asp Leu Lys Ser Phe Leu Thr His Ala Arg Lys Asn Leu Pro Phe
170 175 180ACG GCT AAA ATT GAA ATT GAA TGC GAA AGC TTT GAA GAG GCC AAA AAC 630Thr Ala Lys Ile Glu Ile Glu Cys Glu Ser Phe Glu Glu Ala Lys Asn
185 190 195GCC ATG AAT GCG GGA GCG GAT ATT GTG ATG TGC GAT AAT TTG AGC GTT 678Ala Met Asn Ala Gly Ala Asp Ile Val Met Cys Asp Asn Leu Ser Val
200 205 210TTA GAG ACT AAA GAA ATT GCC GCT TAT AGA GAT GCG CAT TAT CCC TTT 726Leu Glu Thr Lys Glu Ile Ala Ala Tyr Arg Asp Ala His Tyr Pro Phe
215 220 225GTT TTA CTG GAA GCG AGC GGG AAC ATT TCA CTA GAG AGC ATT AAC GCT 774Val Leu Leu Glu Ala Ser Gly Asn Ile Ser Leu Glu Ser Ile Asn Ala230 235 240 245TAC GCT AAA AGC GGC GTG GAT GCC ATT AGC GTA GGG GCT TTA ATC CAT 822Tyr Ala Lys Ser Gly Val Asp Ala Ile Ser Val Gly Ala Leu Ile His
250 255 260CAA GCC ACT TTT ATT GAC ATG CAC ATG AAA ATG GCT TAAAGACTTT AAAAAG 874Gln Ala Thr Phe Ile Asp Met His Met Lys Met Ala
265 270GGGTTATTAA CATGCTAAAA GAATATTTAG AAAGCATTAA AGATCTTACG CCTGAAAAGA 934ATGAACTCAC GCACCGCCCT TCTTTATACA ACTTGCTTAA TCAGTTAAAA AACCAT 990
(2) Sequence 556 data:
(i) sequence characteristics:
(A) length: 273 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 556: met Glu Ile Arg Thr Phe Leu Glu Arg Ala Leu Lys Glu Asp Leu Gly 151015 His Gly Asp Leu Phe Glu Arg Val Leu Glu Lys Asp Phe Lys Ala Thr
20 25 30Ala Phe Val Arg Ala Lys Gln Glu Gly Val Phe Ser Gly Glu Lys Tyr
35 40 45Ala Leu Glu Leu Leu Glu Met Thr Gly Ile Glu Cys Val Gln Thr Ile
50 55 60Lys Asp Lys Glu Arg Phe Lys Pro Lys Asp Ala Leu Met Glu Ile Arg65 70 75 80Gly Asp Phe Ser Met Leu Leu Lys Val Glu Arg Thr Leu Leu Asn Leu
85 90 95Leu Gln His Ser Ser Gly Ile Ala Thr Leu Thr Ser Arg Phe Val Glu
100 105 110Ala Leu Asn Ser His Lys Val Arg Leu Leu Asp Thr Arg Lys Thr Arg
115 120 125Pro Leu Leu Arg Ile Phe Glu Lys Tyr Ser Val Leu Asn Gly Gly Ala
130 135 140Ser Asn His Arg Leu Gly Leu Asp Asp Ala Leu Met Leu Lys Asp Thr145 150 155 160His Leu Arg His Val Lys Asp Leu Lys Ser Phe Leu Thr His Ala Arg
165 170 175Lys Asn Leu Pro Phe Thr Ala Lys Ile Glu Ile Glu Cys Glu Ser Phe
180 185 190Glu Glu Ala Lys Asn Ala Met Asn Ala Gly Ala Asp Ile Val Met Cys
195 200 205Asp Asn Leu Ser Val Leu Glu Thr Lys Glu Ile Ala Ala Tyr Arg Asp
210 215 220Ala His Tyr Pro Phe Val Leu Leu Glu Ala Ser Gly Asn Ile Ser Leu225 230 235 240Glu Ser Ile Asn Ala Tyr Ala Lys Ser Gly Val Asp Ala Ile Ser Val
245 250 255Gly Ala Leu Ile His Gln Ala Thr Phe Ile Asp Met His Met Lys Met
260 265 270Ala
(2) Sequence 557 data:
(i) sequence characteristics:
(A) length: 1153bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1100
(D) Other information:
(xi) Description of the sequence: sequence 557: GATCAAACGC TACAACCCTA GCTGTCTTTT AGAAGTGGAT GGGGGCGTGA ATG ATA 56
Met Ile
1AAA ATA TCT TTG AAC TCC AAC AAG CGG GCG TGG ATG TGG TGG TTT CAG 104Lys Ile Ser Leu Asn Ser Asn Lys Arg Ala Trp Met Trp Trp Phe Gln
5 10 15GGA GTT ATA TTT TTA AAT CCA AAG ATC GTA AGC TGG CTA TTG AAG GCT 152Gly Val Ile Phe Leu Asn Pro Lys Ile Val Ser Trp Leu Leu Lys Ala
20 25 30TAC AGA ATG TCA GAC AAT CTC TTG CAT AAA GAC ATC CAA GCC CTA ATC 200Tyr Arg Met Ser Asp Asn Leu Leu His Lys Asp Ile Gln Ala Leu Ile35 40 45 50GCT CGC TTA AAG CGC CAG GAC TTA AGC TTG GGC ATG CTA GAA AAA TCG 248Ala Arg Leu Lys Arg Gln Asp Leu Ser Leu Gly Met Leu Glu Lys Ser
55 60 65CTC TCT CGC CTT ATT CAT GAT GAA ATC AAT TTG GAG TAT TTG AAG GCG 296Leu Ser Arg Leu Ile His Asp Glu Ile Asn Leu Glu Tyr Leu Lys Ala
70 75 80TGC GGG CTC AAT TTC ATA GAA ACG AGC GAA AAT TTA ATC ACG CTC AAA 344Cys Gly Leu Asn Phe Ile Glu Thr Ser Glu Asn Leu Ile Thr Leu Lys
85 90 95AAC CTT AAA ACC CCC CTT AAA GAT GAG GTT TTT TCC TTT ATT GAT TTA 392Asn Leu Lys Thr Pro Leu Lys Asp Glu Val Phe Ser Phe Ile Asp Leu
100 105 110GAA ACC ACC GGA TCT TGC CCC ATA AAG CAT GAG ATT TTA GAA ATT GGG 440Glu Thr Thr Gly Ser Cys Pro Ile Lys His Glu Ile Leu Glu Ile Gly115 120 125 130GCC GTG CAA GTG AAA GGG GGG GAA ATT ATC AAT CGT TTT GAA ACC CTT 488Ala Val Gln Val Lys Gly Gly Glu Ile Ile Asn Arg Phe Glu Thr Leu
135 140 145GTG AAA GTC AAA AGC GTG CCT GAT TAT ATC GCT GAG CTT ACA GGC ATC 536Val Lys Val Lys Ser Val Pro Asp Tyr Ile Ala Glu Leu Thr Gly Ile
150 155 160ACT TAT GAA GAC ACC CTA AAC GCC CCA AGC GCG CAT GAA GCT TTG CAA 584Thr Tyr Glu Asp Thr Leu Asn Ala Pro Ser Ala His Glu Ala Leu Gln
165 170 175GAA TTG CGG CTT TTT TTA GGC AAT AGC GTG TTT GTG GCC CAC AAC GCT 632Glu Leu Arg Leu Phe Leu Gly Asn Ser Val Phe Val Ala His Asn Ala
180 185 190AAT TTT GAT TAC AAC TTT TTG GGG CGT TAT TTT GTA GAA AAA TTG CAT 680Asn Phe Asp Tyr Asn Phe Leu Gly Arg Tyr Phe Val Glu Lys Leu His195 200 205 210TGC CCT TTA TTG AAT TTA AAG CTT TGC ACT CTG GAT TTA TCC AAA CGA 728Cys Pro Leu Leu Asn Leu Lys Leu Cys Thr Leu Asp Leu Ser Lys Arg
215 220 225GCC ATT TTG TCC ATG CGT TAT TCT TTG AGC TTT TTA AAA GAG CTT TTA 776Ala Ile Leu Ser Met Arg Tyr Ser Leu Ser Phe Leu Lys Glu Leu Leu
230 235 240GGG TTT GGT ATA GAA GTC AGC CAT AGA GCC TAT GCG GAC GCT TTA GCG 824Gly Phe Gly Ile Glu Val Ser His Arg Ala Tyr Ala Asp Ala Leu Ala
245 250 255AGC TAT AAA CTC TTT GAA ATA TGC CTG TTA AAC TTG CCC AGC TAC ATC 872Ser Tyr Lys Leu Phe Glu Ile Cys Leu Leu Asn Leu Pro Ser Tyr Ile
260 265 270AAA ACG ACA ATG GAT TTG ATT GAT TTT TCT AAA TGT GCT AAC ACG CTA 920Lys Thr Thr Met Asp Leu Ile Asp Phe Ser Lys Cys Ala Asn Thr Leu275 280 285 290ATC AAA AGA CCC CCA AAA GCC AGA TAC CAA GAG ATT CCA TCG CCA TTT 968Ile Lys Arg Pro Pro Lys Ala Arg Tyr Gln Glu Ile Pro Ser Pro Phe
295 300 305TCT CTT TTT GAA AAG ACA AAG GGC TTG TTC AAT CAT AAA AGC AAC CAG 1016Ser Leu Phe Glu Lys Thr Lys Gly Leu Phe Asn His Lys Ser Asn Gln
310 315 320TTA AAC GAA AGC TGT TTA ATG GGG TTT ATG GGG ACT GAA ATT TTA GCA 1064Leu Asn Glu Ser Cys Leu Met Gly Phe Met Gly Thr Glu Ile Leu Ala
325 330 335TCT CTA TTT GAT ACT TTT GAA TGT TGC CTA GTA TTT TGATTTTATC GGTTAC 1116Ser Leu Phe Asp Thr Phe Glu Cys Cys Leu Val Phe
340 345 350TTCGCACTCA TCGTATATCT TTTTGTATTC TTGTATG 1153
(2) Sequence 558 data:
(i) sequence characteristics:
(A) length: 350 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 558: met Ile Lys Ile Ser Leu Asn Ser Asn Lys Arg Ala Trp Met Trp Trp 151015 Phe Gln Gly Val Ile Phe Leu Asn Pro Lys Ile Val Ser Trp Leu Leu
20 25 30Lys Ala Tyr Arg Met Ser Asp Asn Leu Leu His Lys Asp Ile Gln Ala
35 40 45Leu Ile Ala Arg Leu Lys Arg Gln Asp Leu Ser Leu Gly Met Leu Glu
50 55 60Lys Ser Leu Ser Arg Leu Ile His Asp Glu Ile Asn Leu Glu Tyr Leu65 70 75 80Lys Ala Cys Gly Leu Asn Phe Ile Glu Thr Ser Glu Asn Leu Ile Thr
85 90 95Leu Lys Asn Leu Lys Thr Pro Leu Lys Asp Glu Val Phe Ser Phe Ile
100 105 110Asp Leu Glu Thr Thr Gly Ser Cys Pro Ile Lys His Glu Ile Leu Glu
115 120 125Ile Gly Ala Val Gln Val Lys Gly Gly Glu Ile Ile Asn Arg Phe Glu
130 135 140Thr Leu Val Lys Val Lys Ser Val Pro Asp Tyr Ile Ala Glu Leu Thr145 150 155 160Gly Ile Thr Tyr Glu Asp Thr Leu Asn Ala Pro Ser Ala His Glu Ala
165 170 175Leu Gln Glu Leu Arg Leu Phe Leu Gly Asn Ser Val Phe Val Ala His
180 185 190Asn Ala Asn Phe Asp Tyr Asn Phe Leu Gly Arg Tyr Phe Val Glu Lys
195 200 205Leu His Cys Pro Leu Leu Asn Leu Lys Leu Cys Thr Leu Asp Leu Ser
210 215 220Lys Arg Ala Ile Leu Ser Met Arg Tyr Ser Leu Ser Phe Leu Lys Glu225 230 235 240Leu Leu Gly Phe Gly Ile Glu Val Ser His Arg Ala Tyr Ala Asp Ala
245 250 255Leu Ala Ser Tyr Lys Leu Phe Glu Ile Cys Leu Leu Asn Leu Pro Ser
260 265 270Tyr Ile Lys Thr Thr Met Asp Leu Ile Asp Phe Ser Lys Cys Ala Asn
275 280 285Thr Leu Ile Lys Arg Pro Pro Lys Ala Arg Tyr Gln Glu Ile Pro Ser
290 295 300Pro Phe Ser Leu Phe Glu Lys Thr Lys Gly Leu Phe Asn His Lys Ser305 310 315 320Asn Gln Leu Asn Glu Ser Cys Leu Met Gly Phe Met Gly Thr Glu Ile
325 330 335Leu Ala Ser Leu Phe Asp Thr Phe Glu Cys Cys Leu Val Phe
340 345 350
(2) Sequence 559 data:
(i) sequence characteristics:
(A) length: 990bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52..864
(D) Other information:
(xi) Description of the sequence: sequence 559: AAAAACACTT TTTAATGTTA TAATCTATCC TAAACAATAT AAGGGGTTTT T ATG GCA 57
Met Ala
1AAA ATT GAA AGC AAT GAT TCC CAC CTA AGA GGT ATT TTA AAA GAC GAA 105Lys Ile Glu Ser Asn Asp Ser His Leu Arg Gly Ile Leu Lys Asp Glu
5 10 15CTC TAC TAT CAA ATC CCC ATC TAC CAA CGC CCT TAT CAA TGG ACA GAA 153Leu Tyr Tyr Gln Ile Pro Ile Tyr Gln Arg Pro Tyr Gln Trp Thr Glu
20 25 30GAA AAC TGC GAA AAA CTT TTA GAC GAT TTG TTT TTT AAT TAT GAA GAT 201Glu Asn Cys Glu Lys Leu Leu Asp Asp Leu Phe Phe Asn Tyr Glu Asp35 40 45 50GAC AGA GAA GGC GAT TAT TTT TGC GGC TCA TTA GTC TTA ATT GCA ATC 249Asp Arg Glu Gly Asp Tyr Phe Cys Gly Ser Leu Val Leu Ile Ala Ile
55 60 65AGC AAA GAT TCT AAA GCC ACA ACC TAT GAT GTT GTA GAT GGC CAG CAA 297Ser Lys Asp Ser Lys Ala Thr Thr Tyr Asp Val Val Asp Gly Gln Gln
70 75 80CGC TTA AGC ACT TTC ATT CTG CTT GCA AAA GTT TTA GCC GAT CTT TAT 345Arg Leu Ser Thr Phe Ile Leu Leu Ala Lys Val Leu Ala Asp Leu Tyr
85 90 95AAT GAT TGT TTA GAC CCT AAG AAT TTA GAA CAT TTA CAA GAG GGT TGG 393Asn Asp Cys Leu Asp Pro Lys Asn Leu Glu His Leu Gln Glu Gly Trp
100 105 110AAA GAT AGG CAT ACA GAA AGA AAA CGA CTG AGT TTT AAC ACT ATA GGG 441Lys Asp Arg His Thr Glu Arg Lys Arg Leu Ser Phe Asn Thr Ile Gly115 120 125 130TCT AAC GCT GAA TAT GAT TTT CAA GAT GCA TTA GAA CAT TTC AAC GAC 489Ser Asn Ala Glu Tyr Asp Phe Gln Asp Ala Leu Glu His Phe Asn Asp
135 140 145TCT CAA GCA AGC AAG AAT AAA AAT AAT AAG AAC AAT TAC CTA AAA AAT 537Ser Gln Ala Ser Lys Asn Lys Asn Asn Lys Asn Asn Tyr Leu Lys Asn
150 155 160GCG ATC TGT TTA AAA GAC TAT CTC ATG AAA AAA GAG ATT AAA AAC ATT 585Ala Ile Cys Leu Lys Asp Tyr Leu Met Lys Lys Glu Ile Lys Asn Ile
165 170 175AAC GAT TTC ATT GAG TGG CTG TAT TCT AAT GTT AAA TTT ATC ACC ATC 633Asn Asp Phe Ile Glu Trp Leu Tyr Ser Asn Val Lys Phe Ile Thr Ile
180 185 190ATT TGC CCA AAC ATA GAC AAG GCA TTA AGG ATT TTT AAT GTT TTA AAC 681Ile Cys Pro Asn Ile Asp Lys Ala Leu Arg Ile Phe Asn Val Leu Asn195 200 205 210GCT AGG GGT TTG CCT TTG AAT GCG ACA GAT ATT TTT AAG GGG GAA TTA 729Ala Arg Gly Leu Pro Leu Asn Ala Thr Asp Ile Phe Lys Gly Glu Leu
215 220 225TTA AAA CAC GCT AAA GAG CAT GAG CGA GAA GAA TTT GTG TCT CGT TGG 777Leu Lys His Ala Lys Glu His Glu Arg Glu Glu Phe Val Ser Arg Trp
230 235 240AAC GCC TTA AGC CAA AAA TGC TCG GAC AAT GAT TTA ACA ATG GAG ACA 825Asn Ala Leu Ser Gln Lys Cys Ser Asp Asn Asp Leu Thr Met Glu Thr
245 250 255TTA TTC AGT TGG TAT AAC CTA TCT CAA TCC GGT AAC TTC TAGAGACAAA AT 876Leu Phe Ser Trp Tyr Asn Leu Ser Gln Ser Gly Asn Phe
260 265 270GGAAAAAGAG CTCGTTACTT GGTTCAACAT ACTTAACAAA CCCCCCCTAG AATACCTTAA 936GGGCGTAGAG GATTTTTACA ACGCTTATGG TGAGGTGTTA GAAATGCAAG ATCG 990
(2) Sequence 560 data:
(i) sequence characteristics:
(A) length: 271 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 560: met Ala Lys Ile Glu Ser Asn Asp Ser His Leu Arg Gly Ile Leu Lys 151015 Asp Glu Leu Tyr Tyr Gln Ile Pro Ile Tyr Gln Arg Pro Tyr Gln Trp
20 25 30Thr Glu Glu Asn Cys Glu Lys Leu Leu Asp Asp Leu Phe Phe Asn Tyr
35 40 45Glu Asp Asp Arg Glu Gly Asp Tyr Phe Cys Gly Ser Leu Val Leu Ile
50 55 60Ala Ile Ser Lys Asp Ser Lys Ala Thr Thr Tyr Asp Val Val Asp Gly65 70 75 80Gln Gln Arg Leu Ser Thr Phe Tle Leu Leu Ala Lys Val Leu Ala Asp
85 90 95Leu Tyr Asn Asp Cys Leu Asp Pro Lys Asn Leu Glu His Leu Gln Glu
100 105 110Gly Trp Lys Asp Arg His Thr Glu Arg Lys Arg Leu Ser Phe Asn Thr
115 120 125Ile Gly Ser Asn Ala Glu Tyr Asp Phe Gln Asp Ala Leu Glu His Phe
130 135 140Asn Asp Ser Gln Ala Ser Lys Asn Lys Asn Asn Lys Asn Asn Tyr Leu145 150 155 160Lys Asn Ala Ile Cys Leu Lys Asp Tyr Leu Met Lys Lys Glu Ile Lys
165 170175Asn Ile Asn Asp Phe Ile Glu Trp Leu Tyr Ser Asn Val Lys Phe Ile
180 185 190Thr Ile Ile Cys Pro Asn Ile Asp Lys Ala Leu Arg Ile Phe Asn Val
195 200 205Leu Asn Ala Arg Gly Leu Pro Leu Asn Ala Thr Asp Ile Phe Lys Gly
210 215 220Glu Leu Leu Lys His Ala Lys Glu His Glu Arg Glu Glu Phe Val Ser225 230 235 240Arg Trp Asn Ala Leu Ser Gln Lys Cys Ser Asp Asn Asp Leu Thr Met
245 250 255Glu Thr Leu Phe Ser Trp Tyr Asn Leu Ser Gln Ser Gly Asn Phe
260 265 270
(2) Sequence 561 data:
(i) sequence characteristics:
(A) length: 283bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...230
(D) Other information:
(xi) Description of the sequence: sequence 561: CCCTAGAATG CGTGCTTTTG GCTAAGGAAT TTTTGCCTAA CGCTAGGCTT ATG GTG 56
Met Val
1GCT GGG GGG CGT GAA GTG GTG TTT AAA GAT AAT GAC AAA AAG GAA GCC 104Ala GlyGly Arg Glu Val Val Phe Lys Asp Asn Asp Lys Lys Glu Ala
5 10 15AAG CTT TTT GAA TAC GGC ATC AAT GCG GTG GTG CTA GGG GAC TAT TTG 152Lys Leu Phe Glu Tyr Gly Ile Asn Ala Val Val Leu Gly Asp Tyr Leu
20 25 30ACC ACC AAA GGC AAA GCC CCT AAA AAA GAT ATA GAA AAA CTG CTC TCT 200Thr Thr Lys Gly Lys Ala Pro Lys Lys Asp Ile Glu Lys Leu Leu Ser35 40 45 50TAT GGC TTG ACA ATG GCG ACA AGC TGT CAT TAATGAGAGA ACTTTTTAAA AGC 253Tyr Gly Leu Thr Met Ala Thr Ser Cys His
55 60GTTAGAGGGT TTTTTCGCCT TCTTAGAATG 283
(2) Sequence 562 data:
(i) sequence characteristics:
(A) length: 60 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 562: met Val Ala Gly Gly Arg Glu Val Val Phe Lys Asp Asn Asp Lys Lys 151015 Glu Ala Lys Leu Phe Glu Tyr Gly Ile Asn Ala Val Val Leu Gly Asp
20 25 30Tyr Leu Thr Thr Lys Gly Lys Ala Pro Lys Lys Asp Ile Glu Lys Leu
35 40 45Leu Ser Tyr Gly Leu Thr Met Ala Thr Ser Cys His
50 55 60
(2) Sequence 563 data:
(i) sequence characteristics:
(A) length: 478bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...425
(D) Other information:
(xi) Description of the sequence: sequence 563: CACTTGTTTG GAGTGCCTAT AGGCATAATA AGTCCTGTTT CTATTTTTAA TGG TGG 56
Trp Trp
1TAT GAT AAC AAT GTC AAC TTA CAG CTT TTT TAT GGA TTT TTA CAC AAT 104Tyr Asp Asn Asn Val Asn Leu Gln Leu Phe Tyr Gly Phe Leu His Asn
5 10 15GTG TAT GAA AAT GAG AAG TTT TTC ATC GGT TAT TTT ATA GGG GCT GGG 152Val Tyr Glu Asn Glu Lys Phe Phe Ile Gly Tyr Phe Ile Gly Ala Gly
20 25 30CTA GGG GGT GAG AGC GTA ACA CCC AAT GTT CTT AAA GAT TTT GGT AAT 200Leu Gly Gly Glu Ser Val Thr Pro Asn Val Leu Lys Asp Phe Gly Asn35 40 45 50ATG TTA GCG CAA TTA GTG CAA TTT CAG GGC TAT GGC TCA CTA GGG CTA 248Met Leu Ala Gln Leu Val Gln Phe Gln Gly Tyr Gly Ser Leu Gly Leu
55 60 65AGG ATG GGC GAT AAA CAC CAC ACG CTA GAA TTG AGC ACG AGC GTT CAT 296Arg Met Gly Asp Lys His His Thr Leu Glu Leu Ser Thr Ser Val His
70 75 80GGC GAC GCT CCTAGT TGT TCT TTA AAA AAG CTA AAG AGT TGC GAA AGT 344Gly Asp Ala Pro Ser Cys Ser Leu Lys Lys Leu Lys Ser Cys Glu Ser
85 90 95GCG AGG GTT TTA CAA GCA AAA ATC CCT AGG GGC ATT TTT GAA AGC TAT 392Ala Arg Val Leu Gln Ala Lys Ile Pro Arg Gly Ile Phe Glu Ser Tyr
100 105 110GTT ACT TGG AGC GCG GAT TAT GTT TAT CGT TTT TAAAAGTTTT TAAAAATTTA 445Val Thr Trp Ser Ala Asp Tyr Val Tyr Arg Phe115 120 125ATGGCTTTGT TCCAATTGAA TAGGGGTAAT AAA 478
(2) Sequence 564 data:
(i) sequence characteristics:
(A) length: 125 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 564: trp Trp Tyr Asp Asn Asn Val Asn Leu Gln Leu Phe Tyr Gly Phe Leu 151015 His Asn Val Tyr Glu Asn Glu Lys Phe Phe Ile Gly Tyr Phe Ile Gly
20 25 30Ala Gly Leu Gly Gly Glu Ser Val Thr Pro Asn Val Leu Lys Asp Phe
35 40 45Gly Asn Met Leu Ala Gln Leu Val Gln Phe Gln Gly Tyr Gly Ser Leu
50 55 60Gly Leu Arg Met Gly Asp Lys His His Thr Leu Glu Leu Ser Thr Ser65 70 75 80Val His Gly Asp Ala Pro Ser Cys Ser Leu Lys Lys Leu Lys Ser Cys
85 9095Glu Ser Ala Arg Val Leu Gln Ala Lys Ile Pro Arg Gly Ile Phe Glu
100 105 110Ser Tyr Val Thr Trp Ser Ala Asp Tyr Val Tyr Arg Phe
115 120 125
(2) Sequence 565 data:
(i) sequence characteristics:
(A) length: 2169bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 53...2119
(D) Other information:
(xi) Description of the sequence: sequence 565: CTTTTAAAAG GCTAATGCCT TTTTAAAAAA TTGAAATAAA GGAATAAAAG TT ATG ACG 58
Met Thr
1GAT AAC AAC CAA AAC AAT GAA AAC CAT GAA AAG AGC AGT GAA AAT TCA 106Asp Asn Asn Gln Asn Asn Glu Asn His Glu Asn Ser Ser Glu Asn Ser
5 10 15AAA GCT GAT GAG ATG CGA GCC GGA GCG TTT GAG CGC TTC ACC AAC CGC 154Lys Ala Asp Glu Met Arg Ala Gly Ala Phe Glu Arg Phe Thr Asn Arg
20 25 30AAA AAG CGT TTC AGA GAA AAC GCG CAA AAA AAC GCA GAG TAT TCA AAC 202Lys Lys Arg Phe Arg Glu Asn Ala Gln Lys Asn Ala Glu Tyr Ser Asn35 40 45 50CAT GAA GCG TCT TCG CAC CATAAA AAA GAG CAT CGC CCT AAC AAA AAA 250His Glu Ala Ser Ser His His Lys Lys Glu His Arg Pro Asn Lys Lys
55 60 65CCA AAC AAC CAC CAC AAA CAA AAA CAT GCC AAA ACA CGA AAT TAC GCC 298Pro Asn Asn His His Lys Gln Lys His Ala Lys Thr Arg Asn Tyr Ala
70 75 80CAA GAA GAA TTG GAT AGC AAC AAA GTA GAG GGC GTT ACG GAA ATT TTG 346Gln Glu Glu Leu Asp Ser Asn Lys Val Glu Gly Val Thr Glu Ile Leu
85 90 95CAT GTG AAT GAG AGA GGG ACT TTA GGC TTT CAT AAG GAG TTA AAA AAG 394His Val Asn Glu Arg Gly Thr Leu Gly Phe His Lys Glu Leu Lys Lys
100 105 110GGC GTT GAA GCG AAT AAC AAG ATC CAA GTG GAG CAT TTA AAC CCG CAT 442Gly Val Glu Ala Asn Asn Lys Ile Gln Val Glu His Leu Asn Pro His115 120 125 130TAT AAG ATG AAC TTA AAC TCT AAA GCG AGC GTT AAA ATC ACG CCT TTA 490Tyr Lys Met Asn Leu Asn Ser Lys Ala Ser Val Lys Ile Thr Pro Leu
135 140 145GGG GGC TTG GGT GAG ATT GGG GGG AAC ATG ATG GTC ATT GAA ACC CCA 538Gly Gly Leu Gly Glu Ile Gly Gly Asn Met Met Val Ile Glu Thr Pro
150 155 160AAA AGC GCG ATC GTG ATT GAT GCG GGC ATG AGC TTC CCT AAA GAG GGG 586Lys Ser Ala Ile Val Ile Asp Ala Gly Met Ser Phe Pro Lys Glu Gly
165 170 175CTC TTT GGC GTG GAT ATT TTA ATC CCG GAT TTT TCC TAC TTG CAC CAA 634Leu Phe Gly Val Asp Ile Leu Ile Pro Asp Phe Ser Tyr Leu His Gln
180 185 190ATC AAG GAC AAA ATC GCT GGC ATT ATC ATC ACC CAT GCC CAT GAA GAT 682Ile Lys Asp Lys Ile Ala Gly Ile Ile Ile Thr His Ala His Glu Asp195 200 205 210CAC ATA GGG GCC ACG CCT TAT TTG TTT AAA GAG CTG CAA TTC CCC CTT 730His Ile Gly Ala Thr Pro Tyr Leu Phe Lys Glu Leu Gln Phe Pro Leu
215 220 225TAT GGC ACG CCC TTG AGT TTG GGG CTG ATT GGG AGC AAG TTT GAT GAA 778Tyr Gly Thr Pro Leu Ser Leu Gly Leu Ile Gly Ser Lys Phe Asp Glu
230 235 240CAT GGT TTG AAA AAA TAC CGC TCG TAT TTT AAA ATC GTA GAA AAG CGC 826His Gly Leu Lys Lys Tyr Arg Ser Tyr Phe Lys Ile Val Glu Lys Arg
245 250 255TGT CCC ATT AGC GTG GGC GAA TTT ATC ATT GAA TGG ATC CAC ATC ACG 874Cys Pro Ile Ser Val Gly Glu Phe lle Ile Glu Trp Ile His Ile Thr
260 265 270CAT TCT ATC ATT GAC AGC AGC GCT TTA GCG ATC CAA ACT AAA GCC GGA 922His Ser Ile Ile Asp Ser Ser Ala Leu Ala Ile Gln Thr Lys Ala Gly275 280 285 290ACG ATC ATC CAC ACC GGC GAT TTT AAA ATC GAT CAC ACC CCG GTG GAT 970Thr Ile Ile His Thr Gly Asp Phe Lys Ile Asp His Thr Pro Val Asp
295 300 305AAT TTG CCC ACG GAT TTG TAT CGT TTA GCG CAC TAT GGC GAA AAG GGG 1018Asn Leu Pro Thr Asp Leu Tyr Arg Leu Ala His Tyr Gly Glu Lys Gly
310 315 320GTG ATG CTT CTT TTA AGC GAT TCC ACC AAC TCC CAT AAA TCC GGG ACT 1066Val Met Leu Leu Leu Ser Asp Ser Thr Asn Ser His Lys Ser Gly Thr
325 330 335ACG CCG AGT GAA AGC ACC ATA GCG CCG GCT TTT GAT ACC CTT TTT AAA 1114Thr Pro Ser Glu Ser Thr Ile Ala Pro Ala Phe Asp Thr Leu Phe Lys
340345 350GAA GCG CAA GGG AGG GTG ATT ATG AGC ACC TTC TCT AGC AAT ATC CAC 1162Glu Ala Gln Gly Arg Val Ile Met Ser Thr Phe Ser Ser Asn Ile His355 360 365 370CGG GTC TAT CAA GCC ATA CAA TAC GGC ATT AAA TAC AAC CGC AAG ATC 1210Arg Val Tyr Gln Ala Ile Gln Tyr Gly Ile Lys Tyr Asn Arg Lys Ile
375 380 385GCT GTG ATC GGG CGC TCT ATG GAA AAA AAC CTA GAC ATC GCT AGA GAA 1258Ala Val Ile Gly Arg Ser Met Glu Lys Asn Leu Asp Ile Ala Arg Glu
390 395 400TTG GGC TAT ATC CAT TTG CCT TAT CAA TCT TTT ATT GAA GCC AAT GAA 1306Leu Gly Tyr Ile His Leu Pro Tyr Gln Ser Phe Ile Glu Ala Asn Glu
405 410 415GTC GCC AAA TAC CCG GAC AAT GAA ATC TTA ATC GTA ACG ACC GGC TCA 1354Val Ala Lys Tyr Pro Asp Asn Glu Ile Leu Ile Val Thr Thr Gly Ser
420 425 430CAA GGC GAA ACC ATG AGC GCG CTT TAT CGC ATG GCG ACT GAT GAA CAC 1402Gln Gly Glu Thr Met Ser Ala Leu Tyr Arg Met Ala Thr Asp Glu His435 440 445 450CGT CAT ATT TCT ATC AAA CCC AAC GAT TTA GTC ATC ATT TCC GCT AAA 1450Arg His Ile Ser Ile Lys Pro Asn Asp Leu Val Ile Ile Ser Ala Lys
455 460 465GCC ATT CCT GGC AAT GAA GCG AGC GTT TCA GCG GTG TTG AAT TTC TTG 1498Ala Ile Pro Gly Asn Glu Ala Ser Val Ser Ala Val Leu Asn Phe Leu
470 475 480ATC AAA AAA GAA GCT AAA GTG GCT TAT CAA GAA TTT GAC AAT ATC CAT 1546Ile Lys Lys Glu Ala Lys Val Ala Tyr Gln Glu Phe Asp Asn Ile His
485 490 495GTG AGC GGG CAT GCC GCC CAA GAA GAG CAA AAG CTC ATG TTA AGA CTC 1594Val Ser Gly His Ala Ala Gln Glu Glu Gln Lys Leu Met Leu Arg Leu
500 505 510ATT AAG CCT AAG TTT TTC TTA CCC GTG CAT GGG GAA TAT AAC CAT GTC 1642Ile Lys Pro Lys Phe Phe Leu Pro Val His Gly Glu Tyr Asn His Val515 520 525 530GCG CGC CAC AAA CAA ACC GCT ATT TCT TGC GGA GTG CCT GAA AAA AAT 1690Ala Arg His Lys Gln Thr Ala Ile Ser Cys Gly Val Pro Glu Lys Asn
535 540 545ATC TAT TTA ATG GAG GAT GGC GAT CAG GTG GAG GTT GGC CCT GCG TTC 1738Ile Tyr Leu Met Glu Asp Gly Asp Gln Val Glu Val Gly Pro Ala Phe
550 555 560ATC AAA AAA GTC GGC ACG ATT AAA AGC GGG AAA AGC TAT GTG GAT AAC 1786Ile Lys Lys Val Gly Thr Ile Lys Ser Gly Lys Ser Tyr Val Asp Asn
565 570 575CAA AGC AAT TTG AGT ATT GAT ACA AGC ATC GTG CAA CAA AGA GAA GAA 1834Gln Ser Asn Leu Ser Ile Asp Thr Ser Ile Val Gln Gln Arg Glu Glu
580 585 590GTC GCT AGC GCC GGG GTG TTT GTG GCT ACG ATT TTT GTG AAT AAA AAC 1882Val Ala Ser Ala Gly Val Phe Val Ala Thr Ile Phe Val Asn Lys Asn595 600 605 610AAG CAA GCG CTT TTA GAA AGC TCT CAA TTT TCC AGT TTA GGG CTT GTG 1930Lys Gln Ala Leu Leu Glu Ser Ser Gln Phe Ser Ser Leu Gly Leu Val
615 620 625GGT TTC AAA GAT GAA AAG CCT TTG ATC AAA GAA ATT CAA GGG GGC TTA 1978Gly Phe Lys Asp Glu Lys Pro Leu Ile Lys Glu Ile Gln Gly Gly Leu
630 635 640GAG GTG TTA TTG AAA TCC AGC AAC GCC GAA ATT TTG AAT AAC CCT AAA 2026Glu Val Leu Leu Lys Ser Ser Asn Ala Glu Ile Leu Asn Asn Pro Lys
645 650 655AAA TTA GAA GAT CAC ACT CGT AAT TTC ATC AGA AAA GCG CTC TTT AAA 2074Lys Leu Glu Asp His Thr Arg Asn Phe Ile Arg Lys Ala Leu Phe Lys
660 665 670AAG TTT AGA AAA TAC CCG GCT ATC ATT TGT CAT GCC CAT TCT TTT TGATT 2124Lys Phe Arg Lys Tyr Pro Ala Ile Ile Cys His Ala His Ser Phe675 680 685GTAACGCTAT TGCTTCACAA GTTTTAAAAG ATGAAGCGAG CGCGC 2169
(2) Sequence 566 data:
(i) sequence characteristics:
(A) length: 689 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 566: met Thr Asp Asn Asn Gln Asn Asn Glu Asn His Glu Asn Ser Ser Glu 151015 Asn Ser Lys Ala Asp Glu Met Arg Ala Gly Ala Phe Glu Arg Phe Thr
20 25 30Asn Arg Lys Lys Arg Phe Arg Glu Asn Ala Gln Lys Asn Ala Glu Tyr
35 40 45Ser Asn His Glu Ala Ser Ser His His Lys Lys Glu His Arg Pro Asn
50 55 60Lys Lys Pro Asn Asn His His Lys Gln Lys His Ala Lys Thr Arg Asn65 70 75 80Tyr Ala Gln Glu Glu Leu Asp Ser Asn Lys Val Glu Gly Val Thr Glu
85 90 95Ile Leu His Val Asn Glu Arg Gly Thr Leu Gly Phe His Lys Glu Leu
100 105 110Lys Lys Gly Val Glu Ala Asn Asn Lys Ile Gln Val Glu His Leu Asn
115 120 125Pro His Tyr Lys Met Asn Leu Asn Ser Lys Ala Ser Val Lys Ile Thr
130 135 140Pro Leu Gly Gly Leu Gly Glu Ile Gly Gly Asn Met Met Val Ile Glu145 150 155 160Thr Pro Lys Ser Ala Ile Val Ile Asp Ala Gly Met Ser Phe Pro Lys
165 170 175Glu Gly Leu Phe Gly Val Asp Ile Leu Ile Pro Asp Phe Ser Tyr Leu
180 185 190His Gln Ile Lys Asp Lys Ile Ala Gly Ile Ile Ile Thr His Ala His
195 200 205Glu Asp His Ile Gly Ala Thr Pro Tyr Leu Phe Lys Glu Leu Gln Phe
210 215 220Pro Leu Tyr Gly Thr Pro Leu Ser Leu Gly Leu Ile Gly Ser Lys Phe225 230 235 240Asp Glu His Gly Leu Lys Lys Tyr Arg Ser Tyr Phe Lys Ile Val Glu
245 250 255Lys Arg Cys Pro Ile Ser Val Gly Glu Phe Ile Ile Glu Trp Ile His
260 265 270Ile Thr His Ser Ile Ile Asp Ser Ser Ala Leu Ala Ile Gln Thr Lys
275 280 285Ala Gly Thr Ile Ile His Thr Gly Asp Phe Lys Ile Asp His Thr Pro
290 295 300Val Asp Asn Leu Pro Thr Asp Leu Tyr Arg Leu Ala His Tyr Gly Glu305 310 315 320Lys Gly Val Met Leu Leu Leu Ser Asp Ser Thr Asn Ser HisLys Ser
325 330 335Gly Thr Thr Pro Ser Glu Ser Thr Ile Ala Pro Ala Phe Asp Thr Leu
340 345 350Phe Lys Glu Ala Gln Gly Arg Val Ile Met Ser Thr Phe Ser Ser Asn
355 360 365Ile His Arg Val Tyr Gln Ala Ile Gln Tyr Gly Ile Lys Tyr Asn Arg
370 375 380Lys Ile Ala Val Ile Gly Arg Ser Met Glu Lys Asn Leu Asp Ile Ala385 390 395 400Arg Glu Leu Gly Tyr Ile His Leu Pro Tyr Gln Ser Phe Ile Glu Ala
405 410 415Asn Glu Val Ala Lys Tyr Pro Asp Asn Glu Ile Leu Ile Val Thr Thr
420 425 430Gly Ser Gln Gly Glu Thr Met Ser Ala Leu Tyr Arg Met Ala Thr Asp
435 440 445Glu His Arg His Ile Ser Ile Lys Pro Asn Asp Leu Val Ile Ile Ser
450 455 460Ala Lys Ala Ile Pro Gly Asn Glu Ala Ser Val Ser Ala Val Leu Asn465 470 475 480Phe Leu Ile Lys Lys Glu Ala Lys Val Ala Tyr Gln Glu Phe Asp Asn
485 490 495Ile His Val Ser Gly His Ala Ala Gln Glu Glu Gln Lys Leu Met Leu
500 505 510Arg Leu Ile Lys Pro Lys Phe Phe Leu Pro Val His Gly Glu Tyr Asn
515 520 525His Val Ala Arg His Lys Gln Thr Ala Ile Ser Cys Gly Val Pro Glu
530 535 540Lys Asn Ile Tyr Leu Met Glu Asp Gly Asp Gln Val GluVal Gly Pro545 550 555 560Ala Phe Ile Lys Lys Val Gly Thr Ile Lys Ser Gly Lys Ser Tyr Val
565 570 575Asp Asn Gln Ser Asn Leu Ser Ile Asp Thr Ser Ile Val Gln Gln Arg
580 585 590Glu Glu Val Ala Ser Ala Gly Val Phe Val Ala Thr Ile Phe Val Asn
595 600 605Lys Asn Lys Gln Ala Leu Leu Glu Ser Ser Gln Phe Ser Ser Leu Gly
610 615 620Leu Val Gly Phe Lys Asp Glu Lys Pro Leu Ile Lys Glu Ile Gln Gly625 630 635 640Gly Leu Glu Val Leu Leu Lys Ser Ser Asn Ala Glu Ile Leu Asn Asn
645 650 655Pro Lys Lys Leu Glu Asp His Thr Arg Asn Phe Ile Arg Lys Ala Leu
660 665 670Phe Lys Lys Phe Arg Lys Tyr Pro Ala Ile Ile Cys His Ala His Ser
675 680 685Phe
(2) Data of sequence 567:
(i) sequence characteristics:
(A) length: 2770bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 46...2721
(D) Other information:
(xi) Description of the sequence: sequence 567: GAAGACAGAG TCTTTGTACA TGAAAATAAA ACGGTGGTGT TTTGA ATG CTT TTA GAT 57
Met Leu Leu Asp
1TTC AGC AAC CTC AAT GAA GAA CCC TTA AAA AAC CAA ATC AAA GCC GAG 105Phe Ser Asn Leu Asn Glu Glu Pro Leu Lys Asn Gln Ile Lys Ala Glu5 10 15 20TTT TTT AAG GAT AAG AAA TTC CTT TAT AGC GGG GAT AAA ATA GAT TTC 153Phe Phe Lys Asp Lys Lys Phe Leu Tyr Ser Gly Asp Lys Ile Asp Phe
25 30 35ATG CTA AGC TAT AAG CAT TCT AAC GCC ACC TTA CCC ATT TTA TGG GGC 201Met Leu Ser Tyr Lys His Ser Asn Ala Thr Leu Pro Ile Leu Trp Gly
40 45 50GAA GCT AAA AGG GGC GAT TTT GAT GAT TTG GAC AAA GCT TTC ACG CAA 249Glu Ala Lys Arg Gly Asp Phe Asp Asp Leu Asp Lys Ala Phe Thr Gln
55 60 65CTT CTT TTA ACC ATA GGC AAG CAC AGG CTT TAT ACC CAC CAC ACA CCA 297Leu Leu Leu Thr Ile Gly Lys His Arg Leu Tyr Thr His His Thr Pro
70 75 80CCT TAT TTG TGC GCT TTT AAC GCT TTT AAA ATG GAA TTT ATC GCC TTT 345Pro Tyr Leu Cys Ala Phe Asn Ala Phe Lys Met Glu Phe Ile Ala Phe85 90 95 100GAT GAC ACG ATC ACA AGC TTT TTT TAT AAA AGC GAT ATA GAT TTT TCT 393Asp Asp Thr Ile Thr Ser Phe Phe Tyr Lys Ser Asp Ile Asp Phe Ser
105 110 115ATC ACC CCA AGC AAC CAC AAC ACA GAA GGT TTT AAA CAT GCT TTA GAC 441Ile Thr Pro Ser Asn His Asn Thr Glu Gly Phe Lys His Ala Leu Asp
120 125130GCG TTT AAA GCC ATG AGC AAA TCC CAT AAA TTC GTT TTT GAC TTT AAA 489Ala Phe Lys Ala Met Ser Lys Ser His Lys Phe Val Phe Asp Phe Lys
135 140 145ACC CAA AGC CAA GAA TGC AAA GAA TTT ATC AAA AAC CGT TTA AAT TCT 537Thr Gln Ser Gln Glu Cys Lys Glu Phe Ile Lys Asn Arg Leu Asn Ser
150 155 160AGC CAT TTA CTC AGC AAA ATC CAA ATT GAC AAA AAC AAT TTC TTT ACG 585Ser His Leu Leu Ser Lys Ile Gln Ile Asp Lys Asn Asn Phe Phe Thr165 170 175 180ATC TAT CAA AAG TGG CTT GAA ATT GTC AAA CCC ACC ATT GAC ATA AAT 633Ile Tyr Gln Lys Trp Leu Glu Ile Val Lys Pro Thr Ile Asp Ile Asn
185 190 195TGG GAG GTG GCT AAA ACT AAA GAC ATT TTA GAC GCA GAC TAT TAT TTA 681Trp Glu Val Ala Lys Thr Lys Asp Ile Leu Asp Ala Asp Tyr Tyr Leu
200 205 210GCG GAT TTG CTT AGC GAT GGC GAT AAA ACC ATT ATT GAG AAA TTG CAC 729Ala Asp Leu Leu Ser Asp Gly Asp Lys Thr Ile Ile Glu Lys Leu His
215 220 225ACG ATT TTA AGA TCG AGC CAT TAT AAA TTG AAT AGG GGT GTG AAT GAA 777Thr Ile Leu Arg Ser Ser His Tyr Lys Leu Asn Arg Gly Val Asn Glu
230 235 240TTA GGC AAA ATG GAT TTT ATG GAA GTT GGT TTC ACA GAC AGC CAA CAA 825Leu Gly Lys Met Asp Phe Met Glu Val Gly Phe Thr Asp Ser Gln Gln245 250 255 260GCC CAT CAA GAA TTT TGG AGC GTT TAT GAA CGA CCG CCT AAA AGA GAA 873Ala His Gln Glu Phe Trp Ser Val Tyr Glu Arg Pro Pro Lys Arg Glu
265 270 275TTT CAA GCC TCT ATT TTA GAG CGG CGC GAC TTG TTA GTA CCA AGC GAT 921Phe Gln Ala Ser Ile Leu Glu Arg Arg Asp Leu Leu Val Pro Ser Asp
280 285 290GTG AGA GAA AGG AAA GGG GCG TTT TTC ACC CCT AAA ATC TGG GTA GAA 969Val Arg Glu Arg Lys Gly Ala Phe Phe Thr Pro Lys Ile Trp Val Glu
295 300 305AAG AGT CAA GAA TAT TTA GCT AAA GCT TTG GGG CAA GAT TAT CAA GAG 1017Lys Ser Gln Glu Tyr Leu Ala Lys Ala Leu Gly Gln Asp Tyr Gln Glu
310 315 320GAT TGT ATC ATT TGG GAT TGC GCT GGG GGG ACT GGG AAT TTG CTT CGA 1065Asp Cys Ile Ile Trp Asp Cys Ala Gly Gly Thr Gly Asn Leu Leu Arg325 330 335 340GGT TTA TTG AAT AAG GCT AAT TTG TAT CTA TCC ACT TTA GAT CAT AAC 1113Gly Leu Leu Asn Lys Ala Asn Leu Tyr Leu Ser Thr Leu Asp His Asn
345 350 355GAT GTG GCA ATC GTT AAA GAT CTG GCT GCA AAA AAC CAC TTA AAA TTA 1161Asp Val Ala Ile Val Lys Asp Leu Ala Ala Lys Asn His Leu Lys Leu
360 365 370CTG GAA AAT CAT GTT TTC CAA TTT GAC TTT TTA AAC GAT GAT TTT TTC 1209Leu Glu Asn His Val Phe Gln Phe Asp Phe Leu Asn Asp Asp Phe Phe
375 380 385AGC GAT AAA ACG CCA AAA AGC TTG CAA GAA ATC TTA AAA GAC AAA GAG 1257Ser Asp Lys Thr Pro Lys Ser Leu Gln Glu Ile Leu Lys Asp Lys Glu
390 395 400AAA CGA AAA AAG CTC ATC ATT TAC ATC AAC CCG CCC TAT GCA GAA GCA 1305Lys Arg Lys Lys Leu Ile Ile Tyr Ile Asn Pro Pro Tyr Ala Glu Ala405 410 415 420GGT AAT AAA TCT AAG ATG AGT GGC ACA GGC GAA CAT AAA GCC AAA GTG 1353Gly Asn Lys Ser Lys Met Ser Gly Thr Gly Glu His Lys Ala Lys Val
425 430 435GCA CGA GAC AAT CTC ATC TGT GAA AAA TAC AAA AAT GAA TTA GGC AAG 1401Ala Arg Asp Asn Leu Ile Cys Glu Lys Tyr Lys Asn Glu Leu Gly Lys
440 445 450GCT AAT AAT GAA GTT TTT GCA CAA TTT TTC ATG CGT ATT TAC AAA GAA 1449Ala Asn Asn Glu Val Phe Ala Gln Phe Phe Met Arg Ile Tyr Lys Glu
455 460 465TTA AAC GGT GTT ATC CTT GCA AGT TTT TCA ACT TTG AAA AAC TTG CAA 1497Leu Asn Gly Val Ile Leu Ala Ser Phe Ser Thr Leu Lys Asn Leu Gln
470 475 480GGA TCT AAT TTT AAA AAA TTC AGA GAA ATC TTT AAA GCT AAA TTT TTA 1545Gly Ser Asn Phe Lys Lys Phe Arg Glu Ile Phe Lys Ala Lys Phe Leu485 490 495 500GAG GGG TTT ATG GTG CCA GCA GAC ACT TTT GAT AAT GTT AGG GGG CAA 1593Glu Gly Phe Met Val Pro Ala Asp Thr Phe Asp Asn Val Arg Gly Gln
505 510 515TTT CCT ATC GGC TTT TTA GTG TGG GAT ACA AGC TCT ATT CTT CCT AAA 1641Phe Pro Ile Gly Phe Leu Val Trp Asp Thr Ser Ser Ile Leu Pro Lys
520 525 530GAA AAC CCC CTA AAT TTA GGG GGC AAC TCT AAA GAA GAG AAA CAA AAC 1689Glu Asn Pro Leu Asn Leu Gly Gly Asn Ser Lys Glu Glu Lys Gln Asn
535 540 545TCC AAT TTA ATC TTA GAC CAA GAC AAT TTG AAA GAT AAT CCC TTG AAA 1737Ser Asn Leu Ile Leu Asp Gln Asp Asn Leu Lys Asp Asn Pro Leu Lys
550 555 560GAG CGT TTT TGC CTT TTA GAC ATA AAC GCT CCT AAT AGG AAG ATG TGT 1785Glu Arg Phe Cys Leu Leu Asp Ile Asn Ala Pro Asn Arg Lys Met Cys565 570 575 580TCC CAA AGC AGA ACA AGA ACT AAG GGG ACA CAA AAG CAT TCT ACA GCA 1833
Ser Gln Ser Arg Thr Arg Thr Lys Gly Thr Gln Lys His Ser Thr Ala
585 590 595GCC CCC TTT GAA ACC CCT TTA CAC ACT GTT AGT TTA GAA ATA TTT GAT 1881Ala Pro Phe Glu Thr Pro Leu His Thr Val Ser Leu Glu Ile Phe Asp
600 605 610AGT TTC GGC GGA TTT TTA GGC AGT AAA AAA ATA TAC ACT CAC ACA ATA 1929Ser Phe Gly Gly Phe Leu Gly Ser Lys Lys Ile Tyr Thr His Thr Ile
615 620 625GAC AAA ATG CTT ACT TTA GCG GAT TAT TTA CAA AAG TTT CAG CCA ACA 1977Asp Lys Met Leu Thr Leu Ala Asp Tyr Leu Gln Lys Phe Gln Pro Thr
630 635 640AAA AGA GAC ACT ATT TTT GGC TAT TTA GAT CCT GGT CGC AAT AGT TTT 2025Lys Arg Asp Thr Ile Phe Gly Tyr Leu Asp Pro Gly Arg Asn Ser Phe645 650 655 660CAA CAT CAA AAT CTA ATT CAT ATT AGC ATT ATT GAC AAA TCA AAA CAA 2073Gln His Gln Asn Leu Ile His Ile Ser Ile Ile Asp Lys Ser Lys Gln
665 670 675TCG CAT GTA AAA TAT TTT CCA ATC ATT GCA ACT ACA ATT TTG TTG GTA 2121Ser His Val Lys Tyr Phe Pro Ile Ile Ala Thr Thr Ile Leu Leu Val
680 685 690TCT GTA TTT TTC TCC ATC CGC CAT TGC ATC AAA GCC ACA TGG CAA AAC 2169Ser Val Phe Phe Ser Ile Arg His Cys Ile Lys Ala Thr Trp Gln Asn
695 700 705GAT AGG GAT CAA TTT TAC GCC CCC TAT GAC GAT GCG TTC CAA GAC GAC 2217Asp Arg Asp Gln Phe Tyr Ala Pro Tyr Asp Asp Ala Phe Gln Asp Asp
710 715 720AGC GAG TTT AAA AAC AAT TGT TTG ATT TTC ATG CTT TTT CAC ACC CAG2265Ser Glu Phe Lys Asn Asn Cys Leu Ile Phe Met Leu Phe His Thr Gln725 730 735 740AAC CGC ATC ACT ACC GCT CAA GGG ACT AAC CAT TTT ATC CCC TTT AGC 2313Asn Arg Ile Thr Thr Ala Gln Gly Thr Asn His Phe Ile Pro Phe Ser
745 750 755GAA ACT GAA GTC AAT GCC AAA GAA AGA TAT TCT AGC CAC GCT CTA TTA 2361Glu Thr Glu Val Asn Ala Lys Glu Arg Tyr Ser Ser His Ala Leu Leu
760 765 770GAG TTT TTA AAA GGC GAA ATC AAA GAA CTT AAA GAG AAC GAT AGC CTC 2409Glu Phe Leu Lys Gly Glu Ile Lys Glu Leu Lys Glu Asn Asp Ser Leu
775 780 785TTT TTA AGT GCC AAA AAA GAA AAC AAG CCC CTG AAA TTC AGC CCG AGC 2457Phe Leu Ser Ala Lys Lys Glu Asn Lys Pro Leu Lys Phe Ser Pro Ser
790 795 800GCT TCA AAG GTG TTT GAC GCT AGC AGA GAG GTT TAT CGC TAT TAC CAC 2505Ala Ser Lys Val Phe Asp Ala Ser Arg Glu Val Tyr Arg Tyr Tyr His805 810 815 820ACA CAA GAT TTC ACA AAC CGC CCC TAT AAC GCT AAC GCA AGC CTT TAT 2553Thr Gln Asp Phe Thr Asn Arg Pro Tyr Asn Ala Asn Ala Ser Leu Tyr
825 830 835GAC ATC AAA GAA TTT TTT CAA GGC CGT AAC AAG CAA GGC AAA TTA AAT 2601Asp Ile Lys Glu Phe Phe Gln Gly Arg Asn Lys Gln Gly Lys Leu Asn
840 845 850TTA CCC GCT AAA GCT AAA GAT GAA TAT TAC AAA CAG CTT TAC GCT AAT 2649Leu Pro Ala Lys Ala Lys Asp Glu Tyr Tyr Lys Gln Leu Tyr Ala Asn
855 860 865TTG CAA GAC GCC CTA AAA GAT CTC GCC AAA GAA ATA CAG CCT AAA GTC 2697Leu Gln Asp Ala Leu Lys Asp Leu Ala Lys Glu Ile Gln Pro Lys Val
870 875 880TAT GAA TAC GGG TTT TTA AGG GAG TGATTTTTAA GACAAATAAT CAAAAAGCTA 2751Tyr Glu Tyr Gly Phe Leu Arg Glu885 890GAGCAAGCGG TATTTTTTA 2770
(2) Sequence 568 data: (i) sequence characteristics: length (A): 892 amino acids (B) type: amino acid (C) chain type: single (D) topology: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 568: met Leu Leu Asp Phe Ser Asn Leu Asn Glu Glu Pro Leu Lys Asn Gln 151015 Ile Lys Ala Glu Phe Phe Lys Asp Lys Lys Phe Leu Tyr Ser Gly Asp
20 25 30Lys Ile Asp Phe Met Leu Ser Tyr Lys His Ser Asn Ala Thr Leu Pro
35 40 45Ile Leu Trp Gly Glu Ala Lys Arg Gly Asp Phe Asp Asp Leu Asp Lys
50 55 60Ala Phe Thr Gln Leu Leu Leu Thr Ile Gly Lys His Arg Leu Tyr Thr65 70 75 80His His Thr Pro Pro Tyr Leu Cys Ala Phe Asn Ala Phe Lys Met Glu
85 90 95Phe Ile Ala Phe Asp Asp Thr Ile Thr Ser Phe Phe Tyr Lys Ser Asp
100 105 110Ile Asp Phe Ser Ile Thr Pro Ser Asn His Asn Thr Glu Gly Phe Lys
115 120 125His Ala Leu Asp Ala Phe Lys Ala Met Ser Lys Ser His Lys Phe Val
130 135 140Phe Asp Phe Lys Thr Gln Ser Gln Glu Cys Lys Glu Phe Ile Lys Asn145 150155 160Arg Leu Asn Ser Ser His Leu Leu Ser Lys Ile Gln Ile Asp Lys Asn
165 170 175Asn Phe Phe Thr Ile Tyr Gln Lys Trp Leu Glu Ile Val Lys Pro Thr
180 185 190Ile Asp Ile Asn Trp Glu Val Ala Lys Thr Lys Asp Ile Leu Asp Ala
195 200 205Asp Tyr Tyr Leu Ala Asp Leu Leu Ser Asp Gly Asp Lys Thr Ile Ile
210 215 220Glu Lys Leu His Thr Ile Leu Arg Ser Ser His Tyr Lys Leu Asn Arg225 230 235 240Gly Val Asn Glu Leu Gly Lys Met Asp Phe Met Glu Val Gly Phe Thr
245 250 255Asp Ser Gln Gln Ala His Gln Glu Phe Trp Ser Val Tyr Glu Arg Pro
260 265 270Pro Lys Arg Glu Phe Gln Ala Ser Ile Leu Glu Arg Arg Asp Leu Leu
275 280 285Val Pro Ser Asp Val Arg Glu Arg Lys Gly Ala Phe Phe Thr Pro Lys
290 295 300Ile Trp Val Glu Lys Ser Gln Glu Tyr Leu Ala Lys Ala Leu Gly Gln305 310 315 320Asp Tyr Gln Glu Asp Cys Ile Ile Trp Asp Cys Ala Gly Gly Thr Gly
325 330 335Asn Leu Leu Arg Gly Leu Leu Asn Lys Ala Asn Leu Tyr Leu Ser Thr
340 345 350Leu Asp His Asn Asp Val Ala Ile Val Lys Asp Leu Ala Ala Lys Asn
355 360 365His Leu Lys Leu Leu Glu Asn His Val Phe Gln Phe Asp Phe Leu Asn
370 375 380Asp Asp Phe Phe Ser Asp Lys Thr Pro Lys Ser Leu Gln Glu Ile Leu385 390 395 400Lys Asp Lys Glu Lys Arg Lys Lys Leu Ile Ile Tyr Ile Asn Pro Pro
405 410 415Tyr Ala Glu Ala Gly Asn Lys Ser Lys Met Ser Gly Thr Gly Glu His
420 425 430Lys Ala Lys Val Ala Arg Asp Asn Leu Ile Cys Glu Lys Tyr Lys Asn
435 440 445Glu Leu Gly Lys Ala Asn Asn Glu Val Phe Ala Gln Phe Phe Met Arg
450 455 460Ile Tyr Lys Glu Leu Asn Gly Val Ile Leu Ala Ser Phe Ser Thr Leu465 470 475 480Lys Asn Leu Gln Gly Ser Asn Phe Lys Lys Phe Arg Glu Ile Phe Lys
485 490 495Ala Lys Phe Leu Glu Gly Phe Met Val Pro Ala Asp Thr Phe Asp Asn
500 505 510Val Arg Gly Gln Phe Pro Ile Gly Phe Leu Val Trp Asp Thr Ser Ser
515 520 525Ile Leu Pro Lys Glu Asn Pro Leu Asn Leu Gly Gly Asn Ser Lys Glu
530 535 540Glu Lys Gln Asn Ser Asn Leu Ile Leu Asp Gln Asp Asn Leu Lys Asp545 550 555 560Asn Pro Leu Lys Glu Arg Phe Cys Leu Leu Asp Ile Asn Ala Pro Asn
565 570 575Arg Lys Met Cys Ser Gln Ser Arg Thr Arg Thr Lys Gly Thr Gln Lys
580 585 590His Ser Thr Ala Ala Pro Phe Glu Thr Pro Leu His Thr Val Ser Leu
595 600 605Glu Ile Phe Asp Ser Phe Gly Gly Phe Leu Gly Ser Lys Lys Ile Tyr
610 615 620Thr His Thr Ile Asp Lys Met Leu Thr Leu Ala Asp Tyr Leu Gln Lys625 630 635 640Phe Gln Pro Thr Lys Arg Asp Thr Ile Phe Gly Tyr Leu Asp Pro Gly
645 650 655Arg Asn Ser Phe Gln His Gln Asn Leu Ile His Ile Ser Ile Ile Asp
660 665 670Lys Ser Lys Gln Ser His Val Lys Tyr Phe Pro Ile Ile Ala Thr Thr
675 680 685Ile Leu Leu Val Ser Val Phe Phe Ser Ile Arg His Cys Ile Lys Ala
690 695 700Thr Trp Gln Asn Asp Arg Asp Gln Phe Tyr Ala Pro Tyr Asp Asp Ala705 710 715 720Phe Gln Asp Asp Ser Glu Phe Lys Asn Asn Cys Leu Ile Phe Met Leu
725 730 735Phe His Thr Gln Asn Arg Ile Thr Thr Ala Gln Gly Thr Asn His Phe
740 745 750Ile Pro Phe Ser Glu Thr Glu Val Asn Ala Lys Glu Arg Tyr Ser Ser
755 760 765His Ala Leu Leu Glu Phe Leu Lys Gly Glu Ile Lys Glu Leu Lys Glu
770 775 780Asn Asp Ser Leu Phe Leu Ser Ala Lys Lys Glu Asn Lys Pro Leu Lys785 790 795 800Phe Ser Pro Ser Ala Ser Lys Val Phe Asp Ala Ser Arg Glu Val Tyr
805 810 815Arg Tyr Tyr His Thr Gln Asp Phe Thr Asn Arg Pro Tyr Asn Ala Asn
820 825 830Ala Ser Leu Tyr Asp Ile Lys Glu Phe Phe Gln Gly Arg Asn Lys Gln
835 840 845Gly Lys Leu Asn Leu Pro Ala Lys Ala Lys Asp Glu Tyr Tyr Lys Gln
850 855 860Leu Tyr Ala Asn Leu Gln Asp Ala Leu Lys Asp Leu Ala Lys Glu Ile865 870 875 880Gln Pro Lys Val Tyr Glu Tyr Gly Phe Leu Arg Glu
885890 (2) sequence 569 data: (i) sequence characteristics: length (A): 996bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 948 (D) other information: (xi) Description of the sequence: sequence 569: AAAAGCCACG CAATCAGCCA CAAACATCAT CACACAAGCC TTTGGCTATC AATTATTAAT 60GAGATAAAG ATG TTA GAA TTT ATT TTA AAA ATT CAA GCT AGA GAC TCT AAA 111
Met Leu Glu Phe Ile Leu Lys Ile Gln Ala Arg Asp Ser Lys
1 5 10GGC TTG GTG AGC ACG ATT AGC ACC ACT ATC GCT AAC AAG GGC TAT AAC 159Gly Leu Val Ser Thr Ile Ser Thr Thr Ile Ala Asn Lys Gly Tyr Asn15 20 25 30ATC GTC AAA AAC GAT GAA TTT GTT GAT CCC TTA AAA CAG CGT TTT TTC 207Ile Val Lys Asn Asp Glu Phe Val Asp Pro Leu Lys Gln Arg Phe Phe
35 40 45ATG CGG TTA AAA ATC CAA AAA GAA ATC AAG CCC TTG AAT ACT GAA ATT 255Met Arg Leu Lys Ile Gln Lys Glu Ile Lys Pro Leu Asn Thr Glu Ile
50 55 60AAA GAG CAA GAA GAG CAA TCC TTA AAG ACC GCT CTT TTT AAA GCC CTA 303Lys Glu Gln Glu Glu Gln Ser Leu Lys Thr Ala Leu Phe Lys Ala Leu
65 70 75GAA AAC TTT AAC GAG TTA TTG ATT GAA GTC ATT TTA ACG CAT AAA AAA 351Glu Asn Phe Asn Glu Leu Leu Ile Glu Val Ile Leu Thr His Lys Lys
80 85 90AAC ATC ATT CTG CTC GCT ACT AAA GAG AGC CAT TGC TTA GGG GAT TTG 399Asn Ile Ile Leu Leu Ala Thr Lys Glu Ser His Cys Leu Gly Asp Leu95 100 105 110CTT TTA AGG GTG TAT GGG GGG GAA TTG AAC GCT CAA ATT TTA GGC GTT 447Leu Leu Arg Val Tyr Gly Gly Glu Leu Asn Ala Gln Ile Leu Gly Val
115 120 125ATT TCC AAC CAC GAG ATT TTA CGC CCT TTA GTG GAA AAA TTT GAC ATC 495Ile Ser Asn His Glu Ile Leu Arg Pro Leu Val Glu Lys Phe Asp Ile
130 135 140CCT TAT TTT TAT GCG CCT TGC GAC AAT CAA GTT TTG CAT GAA AAA GAA 543Pro Tyr Phe Tyr Ala Pro Cys Asp Asn Gln Val Leu His Glu Lys Glu
145 150 155GTT TTA GAA ATC ATT AAA AAC CTG GAA TTA AAG CAC AAA GTG AGT GCA 591Val Leu Glu Ile Ile Lys Asn Leu Glu Leu Lys His Lys Val Ser Ala
160 165 170GAC TTG CTC GTT TTA GCC AAA TAC ATG CGC ATT TTA AGC CAT GAT TTT 639Asp Leu Leu Val Leu Ala Lys Tyr Met Arg Ile Leu Ser His Asp Phe175 180 185 190ACG AAG CGC TAT GAA AAC CAG ATC TTA AAT ATC CAT CAT AGT TTC TTG 687Thr Lys Arg Tyr Glu Asn Gln Ile Leu Asn Ile His His Ser Phe Leu
195 200 205CCC GCA TTC ATT GGG GCT AAT CCT TAC CAG CAA GCG TTT GAA AGG GGC 735Pro Ala Phe Ile Gly Ala Asn Pro Tyr Gln Gln Ala Phe Glu Arg Gly
210 215 220GTG AAA GTC ATC GGG GCC ACG GCG CAT TTT GTG AAT GAA AGC CTT GAT 783Val Lys Val Ile Gly Ala Thr Ala His Phe Val Asn Glu Ser Leu Asp
225 230 235GCT GGG CCG ATT ATC ATA CAA GAC ACT CTG CCC ATT AAC CAC AAT TAC 831Ala Gly Pro Ile Ile Ile Gln Asp Thr Leu Pro Ile Asn His Asn Tyr
240 245 250AGC GTG GAA AAA ATG CGC CTA GCG GGT AAG GAT ATA GAA AAA CTG GTT 879Ser Val Glu Lys Met Arg Leu Ala Gly Lys Asp Lle Glu Lys Leu Val255 260 265 270TTA GCT AGG GCT TTA AAA CTC GTT TTA GAA GAC AGA GTC TTT GTA CAT 927Leu Ala Arg Ala Leu Lys Leu Val Leu Glu Asp Arg Val Phe Val His
275 280 285GAA AAT AAA ACG GTG GTG TTT TGAATGCTTT TAGATTTCAG CAACCTCAAT GAAG 982Glu Asn Lys Thr Val Val Phe
290AACCCTTAAA AAAC 996 (2) sequence 570 data: (i) sequence characteristics: length (A): 293 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 570: met Leu Glu Phe Ile Leu Lys lle Gln Ala Arg Asp Ser Lys Gly Leu 151015 Val Ser Thr Ile Ser Thr Thr Ile Ala Asn Lys Gly Tyr Asn Ile Val
20 25 30Lys Asn Asp Glu Phe Val Asp Pro Leu Lys Gln Arg Phe Phe Met Arg
35 40 45Leu Lys Ile Gln Lys Glu Ile Lys Pro Leu Asn Thr Glu Ile Lys Glu
50 55 60Gln Glu Glu Gln Ser Leu Lys Thr Ala Leu Phe Lys Ala Leu Glu Asn65 70 75 80Phe Asn Glu Leu Leu Ile Glu Val Ile Leu Thr His Lys Lys Asn Ile
85 9095Ile Leu Leu Ala Thr Lys Glu Ser His Cys Leu Gly Asp Leu Leu Leu
100 105 110Arg Val Tyr Gly Gly Glu Leu Asn Ala Gln Ile Leu Gly Val Ile Ser
115 120 125Asn His Glu Ile Leu Arg Pro Leu Val Glu Lys Phe Asp Ile Pro Tyr
130 135 140Phe Tyr Ala Pro Cys Asp Asn Gln Val Leu His Glu Lys Glu Val Leu145 150 155 160Glu Ile Ile Lys Asn Leu Glu Leu Lys His Lys Val Ser Ala Asp Leu
165 170 175Leu Val Leu Ala Lys Tyr Met Arg Ile Leu Ser His Asp Phe Thr Lys
180 185 190Arg Tyr Glu Asn Gln Ile Leu Asn Ile His His Ser Phe Leu Pro Ala
195 200 205Phe Ile Gly Ala Asn Pro Tyr Gln Gln Ala Phe Glu Arg Gly Val Lys
210 215 220Val Ile Gly Ala Thr Ala His Phe Val Asn Glu Ser Leu Asp Ala Gly225 230 235 240Pro Ile Ile Ile Gln Asp Thr Leu Pro Ile Asn His Asn Tyr Ser Val
245 250 255Glu Lys Met Arg Leu Ala Gly Lys Asp Ile Glu Lys Leu Val Leu Ala
260 265 270Arg Ala Leu Lys Leu Val Leu Glu Asp Arg Val Phe Val His Glu Asn
275 280 285Lys Thr Val Val Phe
290
(2) Sequence 571 data:
(i) sequence characteristics:
(A) length: 882 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 48...824
(D) Other information:
(xi) Description of the sequence: sequence 571: CGATAGTGTT GTAGGATACT TTTGAAATTT AAGCGGTAAG TTGGATA ATG GCG TTT 56
Met Ala PheTGG CAT AAA AGA TTA GCG GTT GGT TGT TGT ATC GTT TTA TTT TCA TGC 104Trp His Lys Arg Leu Ala Val Gly Cys Cys Ile Val Leu Phe Ser Cys
5 10 15ATG ATG AAC GCT AAT AGC ATT CAA ATC GTT AGA GAC GAT CCG CCC CTT 152Met Met Asn Ala Asn Ser Ile Gln Ile Val Arg Asp Asp Pro Pro Leu20 25 30 35GAT CCA ACG CTC CCT GCA TGG GTT TAT TCT GTT GCG TTA TTA AAA GTG 200Asp Pro Thr Leu Pro Ala Trp Val Tyr Ser Val Ala Leu Leu Lys Val
40 45 50TAT TTT AGC GAT GGG ACT TAT AAA GAA GGC TAT GCG ACT TTG CTC AAA 248Tyr Phe Ser Asp Gly Thr Tyr Lys Glu Gly Tyr Ala Thr Leu Leu Lys
55 60 65AAC GGG CGT TAT ATC GCT TCT TCT GAA ACG CTT TAT TCT AAC GGC TTA 296Asn Gly Arg Tyr Ile Ala Ser Ser Glu Thr Leu Tyr Ser Asn Gly Leu
70 75 80TAC CCT AAA ACG ATT TTA GCC AAA ATG CAA GAC AGC AGC GCT AAA GAG 344Tyr Pro Lys Thr Ile Leu Ala Lys Met Gln Asp Ser Ser Ala Lys Glu
8590 95CTG ATT TGT ATA GCT AGC CTA CGC CTT GAA GCG ATG GAT AGG AAT CAA 392Leu Ile Cys Ile Ala Ser Leu Arg Leu Glu Ala Met Asp Arg Asn Gln100 105 110 115GGG CTT TCG CTT TTA AAA ACC GCC GAT TTT AGA GAC GAT TAT TGC CAT 440Gly Leu Ser Leu Leu Lys Thr Ala Asp Phe Arg Asp Asp Tyr Cys His
120 125 130AAA AGA GAA GAG AGC TAT TAT CAT GCA AGG ATT TAC ACA AAA TAC GCT 488Lys Arg Glu Glu Ser Tyr Tyr His Ala Arg Ile Tyr Thr Lys Tyr Ala
135 140 145CAA ACT TTT CAT TCA AAT CCC TAT ACC AAT CAA AAA ACA CCC AAT TCT 536Gln Thr Phe His Ser Asn Pro Tyr Thr Asn Gln Lys Thr Pro Asn Ser
150 155 160GAT CTC TAC TAC CCA GCG TTA AAT GAG GGG AAT TCT TTT TCT ATA CAG 584Asp Leu Tyr Tyr Pro Ala Leu Asn Glu Gly Asn Ser Phe Ser Ile Gln
165 170 175ATA ATG GGC ATT TCT GTG GCT GAA CTT TTG AAA TCT AAA AAA TTC CTT 632Ile Met Gly Ile Ser Val Ala Glu Leu Leu Lys Ser Lys Lys Phe Leu180 185 190 195TCG CTT GAT GTT TCT TTT AAA AAG GGG AGC GTG TTG TGG GGA GGG AGG 680Ser Leu Asp Val Ser Phe Lys Lys Gly Ser Val Leu Trp Gly Gly Arg
200 205 210CCT TAT TTT AGC GAA GTG GGG GAG TTT ATG GGG ATG GCT AGC AGC ACT 728Pro Tyr Phe Ser Glu Val Gly Glu Phe Met Gly Met Ala Ser Ser Thr
215 220 225TTA GAA AAC CAA GAA AGT CTG GTG ATT ATC CCT AAA GAA AAG ATC GTG 776Leu Glu Asn Gln Glu Ser Leu Val Ile Ile Pro Lys Glu Lys Ile Val
230 235 240CAA TTT TTA AAC GCT CTA AAA AAT CAA AAT ATT TTCCCA AAC ATT CCC T 825Gln Phe Leu Asn Ala Leu Lys Asn Gln Asn Ile Phe Pro Asn Ile Pro
245 250 255AAGTTTAAGC AAACCTTAAG CTTTCTATGA CTATACTTTC ATTTCCTTGT TTCAGCA 882
(2) Sequence 572 data: (i) sequence characteristics: length (A): 259 amino acid (B) types: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 572: met Ala Phe Trp His Lys Arg Leu Ala Val Gly Cys Cys Ile Val Leu 151015 Phe Ser Cys Met Met Asn Ala Asn Ser Ile Gln Ile Val Arg Asp Asp
20 25 30Pro Pro Leu Asp Pro Thr Leu Pro Ala Trp Val Tyr Ser Val Ala Leu
35 40 45Leu Lys Val Tyr Phe Ser Asp Gly Thr Tyr Lys Glu Gly Tyr Ala Thr
50 55 60Leu Leu Lys Asn Gly Arg Tyr Ile Ala Ser Ser Glu Thr Leu Tyr Ser65 70 75 80Asn Gly Leu Tyr Pro Lys Thr Ile Leu Ala Lys Met Gln Asp Ser Ser
85 90 95Ala Lys Glu Leu Ile Cys Ile Ala Ser Leu Arg Leu Glu Ala Met Asp
100 105 110Arg Asn Gln Gly Leu Ser Leu Leu Lys Thr Ala Asp Phe Arg Asp Asp
115 120 125Tyr Cys His Lys Arg Glu Glu Ser Tyr Tyr His Ala Arg Ile Tyr Thr
130 135 140Lys Tyr Ala Gln Thr Phe His Ser Asn Pro Tyr Thr Asn Gln Lys Thr145 150 155 160Pro Asn Ser Asp Leu Tyr Tyr Pro Ala Leu Asn Glu Gly Asn Ser Phe
165 170 175Ser Ile Gln Ile Met Gly Ile Ser Val Ala Glu Leu Leu Lys Ser Lys
180 185 190Lys Phe Leu Ser Leu Asp Val Ser Phe Lys Lys Gly Ser Val Leu Trp
195 200 205Gly Gly Arg Pro Tyr Phe Ser Glu Val Gly Glu Phe Met Gly Met Ala
210 215 220Ser Ser Thr Leu Glu Asn Gln Glu Ser Leu Val Ile Ile Pro Lys Glu225 230 235 240Lys Ile Val Gln Phe Leu Asn Ala Leu Lys Asn Gln Asn Ile Phe Pro
245 250 255Asn Ile Pro
(2) Sequence 573 data:
(i) sequence characteristics:
(A) length: 669 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 88...603
(D) Other information:
(xi) Description of the sequence: sequence 573: AAAATAAGGA GGAATTGTTT GATTTTACGA TTGGCTGGAG CAAGCGTTTT AACGGCTTGT 60GTCTTTTCGG GGTGTTTTTT TTTAAAA ATG TTT GAT AAA AAA CTT TCT AGT AAC 114
Met Phe Asp Lys Lys Leu Ser Ser Asn
1 5GAT TGG CAT ATC CAA AAA GTG GAA ATG AAC CAT CAA GTC TAT GAC ATT 162Asp Trp His Ile Gln Lys Val Glu Met Asn His Gln Val Tyr Asp Ile10 1520 25GAA ACC ATG CTC GCT GAT AGC GCT TTT AGA GAG CAT GAA GAA GAG CAA 210Glu Thr Met Leu Ala Asp Ser Ala Phe Arg Glu His Glu Glu Glu Gln
30 35 40GAT TCC TCT CTA AAT ACC GCT TTG CCT GAA GAT AAA ACA GCG ATT GAA 258Asp Ser Ser Leu Asn Thr Ala Leu Pro Glu Asp Lys Thr Ala Ile Glu
45 50 55GCC AAA GAG CAA GAG CAA AAA GAA AAA AGA AAA CGC TGG TAT GAG CTT 306Ala Lys Glu Gln Glu Gln Lys Glu Lys Arg Lys Arg Trp Tyr Glu Leu
60 65 70TTT AAA AAG AAA CCA AAG CCC AAA AGC TCT ATG GGA GAG TTT GTG TTT 354Phe Lys Lys Lys Pro Lys Pro Lys Ser Ser Met Gly Glu Phe Val Phe
75 80 85GAT CAA AAA GAA AAT CGT ATT TAT GGC AAA GGC TAT TGC AAC CGG TAT 402Asp Gln Lys Glu Asn Arg Ile Tyr Gly Lys Gly Tyr Cys Asn Arg Tyr90 95 100 105TTT GCC AGC TAT GTA TGG CAG GGC GAT AGG CAC ATT GGG ATT GAA GAT 450Phe Ala Ser Tyr Val Trp Gln Gly Asp Arg His Ile Gly Ile Glu Asp
110 115 120AGC GGG ATT TCA AGA AAA GTG TGT AAA GAT GAG CAT TTA ATG GCG TTT 498Ser Gly Ile Ser Arg Lys Val Cys Lys Asp Glu His Leu Met Ala Phe
125 130 135GAA TTG GAA TTT ATG GAG AAT TTT AAG GGT AAT TTT ACG GTA ACT AAG 546Glu Leu Glu Phe Met Glu Asn Phe Lys Gly Asn Phe Thr Val Thr Lys
140 145 150GGC AAG GAC ACG CTC ATT TTA GAC AAC CAA AAA ATG AAA ATT TAT TTG 594Gly Lys Asp Thr Leu Ile Leu Asp Asn Gln Lys Met Lys Ile Tyr Leu
155 160 165AAA ACG CCT TGAGTGGGTT TTTGATTTCA AAACAATCTA AGATCACTAA ATTAGGGAT 652Lys Thr Pro170TAAAAAGAAA TTTTTAA 669
(2) Sequence 574 data: (i) sequence characteristics: length (A): 172 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 574: met Phe Asp Lys Lys Leu Ser Ser Asn Asp Trp His Ile Gln Lys Val 151015 Glu Met Asn His Gln Val Tyr Asp Ile Glu Thr Met Leu Ala Asp Ser
20 25 30Ala Phe Arg Glu His Glu Glu Glu Gln Asp Ser Ser Leu Asn Thr Ala
35 40 45Leu Pro Glu Asp Lys Thr Ala Ile Glu Ala Lys Glu Gln Glu Gln Lys
50 55 60Glu Lys Arg Lys Arg Trp Tyr Glu Leu Phe Lys Lys Lys Pro Lys Pro65 70 75 80Lys Ser Ser Met Gly Glu Phe Val Phe Asp Gln Lys Glu Asn Arg Ile
85 90 95Tyr Gly Lys Gly Tyr Cys Asn Arg Tyr Phe Ala Ser Tyr Val Trp Gln
100 105 110Gly Asp Arg His Ile Gly Ile Glu Asp Ser Gly Ile Ser Arg Lys Val
115 120 125Cys Lys Asp Glu His Leu Met Ala Phe Glu Leu Glu Phe Met Glu Asn
130 135 140Phe Lys Gly Asn Phe Thr Val Thr Lys Gly Lys Asp Thr Leu Ile Leu145 150 155 160Asp Asn Gln Lys Met Lys Ile Tyr Leu Lys Thr Pro
165 170
(2) Sequence 575 data: (i) sequence characteristics: length (A): 290bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 53...235
(D) Other information: (xi) Description of the sequence: sequence 575: TTGAGCTTAA GAAACATTGA TAATTTTGTG GAAAAAGGCT CTGCTTTGAT AG ATA AAT 58
Ile Asn
1TTG ACG CTA ACC CCT ATA AAA CGA TTT TTG GAG AAA GGA AAT AAT CAT 106Leu Thr Leu Thr Pro Ile Lys Arg Phe Leu Glu Lys Gly Asn Asn His
5 10 15GAG AGC TAC GGC GAT AAA AAT CTT TTC ACT CTC ATC AGC ATT AGC CCT 154Glu Ser Tyr Gly Asp Lys Asn Leu Phe Thr Leu Ile Ser Ile Ser Pro
20 25 30ATT GCT TCA TGG TTG CTT GAG CAT CAA TTT AAA ACA AAT GCT ACC AGA 202Ile Ala Ser Trp Leu Leu Glu His Gln Phe Lys Thr Asn Ala Thr Arg35 40 45 50GAT CAG AAC TTA CGA TTT GAA TGC GAG TTC TTT TGAAATCACG CAATGCGCTA 255Asp Gln Asn Leu Arg Phe Glu Cys Glu Phe Phe
55 60AACCTTTGAC TGAAGTGAGG CTCATTAGTA TTTTG 290
(2) Sequence 576 data:
(i) sequence characteristics:
(A) length: 61 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 576: ile Asn Leu Thr Leu Thr Pro Ile Lys Arg Phe Leu Glu Lys Gly Asn 151015 Asn His Glu Ser Tyr Gly Asp Lys Asn Leu Phe Thr Leu Ile Ser Ile
20 25 30Ser Pro Ile Ala Ser Trp Leu Leu Glu His Gln Phe Lys Thr Asn Ala
35 40 45Thr Arg Asp Gln Asn Leu Arg Phe Glu Cys Glu Phe Phe
50 55 60
(2) Sequence 577 data:
(i) sequence characteristics:
(A) length: 810bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 28...771
(D) Other information:
(xi) Description of the sequence: sequence 577: TATCAAAAAA TAAAGGGAAA AGACTGA ATG TTG AAA AGA ATG ATA TTA TTA GGG 54
Met Leu Lys Arg Met Ile Leu Leu Gly
1 5GCT TTG GGT GTT TTA GCG AGC GCT GAA GAG AGT GCG GCT TTT GTG GGA 102Ala Leu Gly Val Leu Ala Ser Ala Glu Glu Ser Ala Ala Phe Val Gly10 15 20 25GTC AAT TAC CAG GTG AGC ATG ATA CAA AAT CAG ACT AAA ATG GTG AAT 150Val Asn Tyr Gln Val Ser Met Ile Gln Asn Gln Thr Lys Met Val Asn
3035 40GAC AAC GGC TTG CAA AAG CCT TTG ATA AAG TTT CCG CCT TAC GCA GGA 198Asp Asn Gly Leu Gln Lys Pro Leu Ile Lys Phe Pro Pro Tyr Ala Gly
45 50 55GCG GGT TTT GAA GTG GGC TAT AAG CAA TTT TTT GGT AAG AAA AAA TGG 246Ala Gly Phe Glu Val Gly Tyr Lys Gln Phe Phe Gly Lys Lys Lys Trp
60 65 70TTT GGC ATG CGT TAT TAT GGG TTT TTT GAC TAC GCG CAC AAC CGC TTT 294Phe Gly Met Arg Tyr Tyr Gly Phe Phe Asp Tyr Ala His Asn Arg Phe
75 80 85GGC GTG ATG AAA AAG GGC ATT CCG GTG GGC GAT AGT GGG TTT ATT TAC 342Gly Val Met Lys Lys Gly Ile Pro Val Gly Asp Ser Gly Phe Ile Tyr90 95 100 105AAT AGT TTT AGT TTT GGA GGG AAC ACT TTA ACG GAA AGG GAT TCC TAT 390Asn Ser Phe Ser Phe Gly Gly Asn Thr Leu Thr Glu Arg Asp Ser Tyr
110 115 120CAG GGG CAA TAC TAT GTC AAT TTA TTC ACT TAT GGC GTG GGG TTA GAT 438Gln Gly Gln Tyr Tyr Val Asn Leu Phe Thr Tyr Gly Val Gly Leu Asp
125 130 135ACG CTG TGG AAT TTT GTG AAT AAA GAA AAC ATG GTT TTT GGT TTT GTG 486Thr Leu Trp Asn Phe Val Asn Lys Glu Asn Met Val Phe Gly Phe Val
140 145 150GTG GGG ATC CAA TTA GCG GGG GAT AGT TGG GCA ACG AGC ATC AGT AAA 534Val Gly Ile Gln Leu Ala Gly Asp Ser Trp Ala Thr Ser Ile Ser Lys
155 160 165GAA ATC GCT CAT TAT GCA AAA CAC CAC AGC AAT TCC AGT TAT AGC CCG 582Glu Ile Ala His Tyr Ala Lys His His Ser Asn Ser Ser Tyr Ser Pro170 175 180 185GCC AAT TTC CAG TTT TTA TGG AAG TTT GGG GTC CGC ACC CAT ATCGCT 630Ala Asn Phe Gln Phe Leu Trp Lys Phe Gly Val Arg Thr His Ile Ala
190 195 200AAA CAC AAT AGC CTA GAA TTA GGG ATT AAA GTG CCT ACG ATC ACA CAC 678Lys His Asn Ser Leu Glu Leu Gly Ile Lys Val Pro Thr Ile Thr His
205 210 215CAG CTT TTC TCT CTT ACC AAC GAA AAG GGA TAC ACC TTA CAG GCT GAT 726Gln Leu Phe Ser Leu Thr Asn Glu Lys Gly Tyr Thr Leu Gln Ala Asp
220 225 230GTG CGT AGA GTT TAT GCG TTT CAA ATC AGT TAC TTG AGG GAT TTT TAACC 776Val Arg Arg Val Tyr Ala Phe Gln Ile Ser Tyr Leu Arg Asp Phe
235 240 245CCTTTTTAGA TACAATCACG CCTGAAACTA TCCA 810
(2) Sequence 578 data: (i) sequence characteristics: length (A): 248 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 578: met Leu Lys Arg Met Ile Leu Leu Gly Ala Leu Gly Val Leu Ala Ser 151015 Ala Glu Glu Ser Ala Ala Phe Val Gly Val Asn Tyr Gln Val Ser Met
20 25 30Ile Gln Asn Gln Thr Lys Met Val Asn Asp Asn Gly Leu Gln Lys Pro
35 40 45Leu Ile Lys Phe Pro Pro Tyr Ala Gly Ala Gly Phe Glu Val Gly Tyr
50 55 60Lys Gln Phe Phe Gly Lys Lys Lys Trp Phe Gly Met Arg Tyr Tyr Gly65 70 75 80Phe Phe Asp Tyr Ala His Asn Arg Phe Gly Val Met Lys Lys Gly Ile
85 90 95Pro Val Gly Asp Ser Gly Phe Ile Tyr Asn Ser PheSer Phe Gly Gly
100 105 110Asn Thr Leu Thr Glu Arg Asp Ser Tyr Gln Gly Gln Tyr Tyr Val Asn
115 120 125Leu Phe Thr Tyr Gly Val Gly Leu Asp Thr Leu Trp Asn Phe Val Asn
130 135 140Lys Glu Asn Met Val Phe Gly Phe Val Val Gly Ile Gln Leu Ala Gly145 150 155 160Asp Ser Trp Ala Thr Ser Ile Ser Lys Glu Ile Ala His Tyr Ala Lys
165 170 175His His Ser Asn Ser Ser Tyr Ser Pro Ala Asn Phe Gln Phe Leu Trp
180 185 190Lys Phe Gly Val Arg Thr His Ile Ala Lys His Asn Ser Leu Glu Leu
195 200 205Gly Ile Lys Val Pro Thr Ile Thr His Gln Leu Phe Ser Leu Thr Asn
210 215 220Glu Lys Gly Tyr Thr Leu Gln Ala Asp Val Arg Arg Val Tyr Ala Phe225 230 235 240Gln Ile Ser Tyr Leu Arg Asp Phe
245
(2) Sequence 579 data: (i) sequence characteristics: length (A): 1354bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1299 (D) other information: (xi) Description of the sequence: sequence 579: AGTAAGCTTG ATTTTAAAAA ACCAAATGCC CCCAAAGCGA TAGGCCCCCT TAATAGCCAA 60CTCAACGCTA TTAAGTGGGG CGAGTTCAGA TTGGGGGATT TGTTTGAAGT GTTGTCAAGT 120AAGAAAATTT ATCATGCCAA CACGATAAAA ATCCATGACA CGCAAATAGA AAACAGCTAC 180CCTTATGTC GTG CGC GCT GCA ACC AAT AAT GGT ATA AAA GGC TTT ATT ATA 231
Val Arg Ala Ala Thr Asn Asn Gly Ile Lys Gly Phe Ile Ile
1 5 10GAT GAC CCT ACA TTT GCT AAT AAA AAA AAT ACC CTT TCG TTC GCG CAA 279Asp Asp Pro Thr Phe Ala Asn Lys Lys Asn Thr Leu Ser Phe Ala Gln15 20 25 30GAC ACT TTC ACT GTG TTT TAT CAA AAA CAA CCT TAT TTT ACA GGC AAT 327Asp Thr Phe Thr Val Phe Tyr Gln Lys Gln Pro Tyr Phe Thr Gly Asn
35 40 45AAG GTT AAA ATT TTA AAA CCA AAA TTT GCT TTC AAA AGC CCT AAA ATT 375Lys Val Lys Ile Leu Lys Pro Lys Phe Ala Phe Lys Ser Pro Lys Ile
50 55 60TTA CAT TCT ATA AGC GCG ATT TTA CAA TTT ATT TTA AAA CCC TTA ACT 423Leu His Ser Ile Ser Ala Ile Leu Gln Phe Ile Leu Lys Pro Leu Thr
65 70 75TGG GGG CTA GGC TCT ACA ACA GAA AGC ATT GCG GAG TTT AAA TTT TCT 471Trp Gly Leu Gly Ser Thr Thr Glu Ser Ile Ala Glu Phe Lys Phe Ser
80 85 90CTA CCC CTA AAA CCC ACC GCT AAC GCT CAA ACC CTT GAG GAT ATT GAT 519Leu Pro Leu Lys Pro Thr Ala Asn Ala Gln Thr Leu Glu Asp Ile Asp95 100 105 110TTT GAT TTC ATG GAA AAA TTC ATA GCC GAA CTT GAG CAG TGT CGG CTC 567Phe Asp Phe Met Glu Lys Phe Ile Ala Glu Leu Glu Gln Cys Arg Leu
115 120 125GCC GAA CTT GAG CAG TGT CGG CTC GCC GAA CTT CAG GCT TAT TTA AAA 615Ala Glu Leu Glu Gln Cys Arg Leu Ala Glu Leu Gln Ala Tyr Leu Lys
130 135 140GCT ACA GGG CTA GAA AAC ACC ACC CTT TCT AAC GAT GAA GAA AAC GCC 663Ala Thr Gly Leu Glu Asn Thr Thr Leu Ser Asn Asp Glu Glu Asn Ala
145 150 155CTT AAT GTT TTC AAT AAT TCT GGG GGG GGG GGG GGT AAT ACC CCA TGC 711Leu Asn Val Phe Asn Asn Ser Gly Gly Gly Gly Gly Asn Thr Pro Cys
160 165 170GGC TTA ACA TGG CAA AGC TTT AGA TTA GGG GAT TTG TTT GAA ATT GAA 759Gly Leu Thr Trp Gln Ser Phe Arg Leu Gly Asp Leu Phe Glu Ile Glu175 180 185 190AAA ACC TTA AGC TTT AAT AAA GAC GCT TTA ACG CAA GGA GAA GAT TAT 807Lys Thr Leu Ser Phe Asn Lys Asp Ala Leu Thr Gln Gly Glu Asp Tyr
195 200 205GAT TAT ATT ACA AGG ACT TCG CAA AAT CAA GGC GTT TTG CAA ACT ACA 855Asp Tyr Ile Thr Arg Thr Ser Gln Asn Gln Gly Val Leu Gln Thr Thr
210 215 220GGA TTT GTC AAT GCA GAA AAT TTA AAC CCA CCA TTT ACT TGG AGT TTA 903Gly Phe Val Asn Ala Glu Asn Leu Asn Pro Pro Phe Thr Trp Ser Leu
225 230 235GGG CTT TTG CAA ATG GAT TTT TTC TAT CGT AAA AAG TCA TGG TAT GCG 951Gly Leu Leu Gln Met Asp Phe Phe Tyr Arg Lys Lys Ser Trp Tyr Ala
240 245 250GGA CAA TTC ATG CGA AAA ATC ACA CCA AAA ACT GAA ATT GAA AAT AAA 999Gly Gln Phe Met Arg Lys Ile Thr Pro Lys Thr Glu Ile Glu Asn Lys255 260 265 270ATT GAT TTA CGC ATA GCC AAC TAC TTC ACA ACG CTT TTA AAC GCC TTA 1047Ile Asp Leu Arg Ile Ala Asn Tyr Phe Thr Thr Leu Leu Asn Ala Leu
275 280 285AAA CGC CCT TTA TTA AGC GTA TTG GTT AGA GAT ATT GAT AAA ACT TTT 1095Lys Arg Pro Leu Leu Ser Val Leu Val Arg Asp Ile Asp Lys Thr Phe
290 295 300AGG GAG CAA AAA ATC CAA CTACCC CTA AAA CCC ACC GCT AAA ACT CAA 1143Arg Glu Gln Lys Ile Gln Leu Pro Leu Lys Pro Thr Ala Lys Thr Gln
305 310 315ACC CTT GAT GGT ATT GAT TTT GAT TTC ATG CAC ACC CTT ATC AAC GCC 1191Thr Leu Asp Gly Ile Asp Phe Asp Phe Met His Thr Leu Ile Asn Ala
320 325 330CTA ATG AAG CAA ACC ATT CAA GGC GTG GCT CAA TAC TGC GAC GCT AAA 1239Leu Met Lys Gln Thr Ile Gln Gly Val Ala Gln Tyr Cys Asp Ala Lys335 340 345 350ATA CAA GCT ACA AAA GAG GTT ATC AGC CAA GAA GCG CCC GTT CAA AAA 1287Ile Gln Ala Thr Lys Glu Val Ile Ser Gln Glu Ala Pro Val Gln Lys
355 360 365GAC TCG TTA TTT TAAAAGGGGT TTTAAGCGCG CTAGCTTGTG TTACAATAAA CTTAA 1344Asp Ser Leu Phe
370AATTCGCTTG 1354
(2) Sequence 580 data: (i) sequence characteristics: length (A): 370 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 580: val Arg Ala Ala Thr Asn Asn Gly Ile Lys Gly Phe Ile Ile Asp Asp 151015 Pro Thr Phe Ala Asn Lys Lys Asn Thr Leu Ser Phe Ala Gln Asp Thr
20 25 30Phe Thr Val Phe Tyr Gln Lys Gln Pro Tyr Phe Thr Gly Asn Lys Val
35 40 45Lys Ile Leu Lys Pro Lys Phe Ala Phe Lys Ser Pro Lys Ile Leu His
50 55 60Ser Ile Ser Ala Ile Leu Gln Phe Ile Leu Lys Pro Leu Thr Trp Gly65 70 75 80Leu Gly Ser Thr Thr Glu Ser Ile Ala Glu Phe Lys Phe Ser Leu Pro
85 90 95Leu Lys Pro Thr Ala Asn Ala Gln Thr Leu Glu Asp Ile Asp Phe Asp
100 105 110Phe Met Glu Lys Phe Ile Ala Glu Leu Glu Gln Cys Arg Leu Ala Glu
115 120 125Leu Glu Gln Cys Arg Leu Ala Glu Leu Gln Ala Tyr Leu Lys Ala Thr
130 135 140Gly Leu Glu Asn Thr Thr Leu Ser Asn Asp Glu Glu Asn Ala Leu Asn145 150 155 160Val Phe Asn Asn Ser Gly Gly Gly Gly Gly Asn Thr Pro Cys Gly Leu
165 170 175Thr Trp Gln Ser Phe Arg Leu Gly Asp Leu Phe Glu Ile Glu Lys Thr
180 185 190Leu Ser Phe Asn Lys Asp Ala Leu Thr Gln Gly Glu Asp Tyr Asp Tyr
195 200 205Ile Thr Arg Thr Ser Gln Asn Gln Gly Val Leu Gln Thr Thr Gly Phe
210 215 220Val Asn Ala Glu Asn Leu Asn Pro Pro Phe Thr Trp Ser Leu Gly Leu225 230 235 240Leu Gln Met Asp Phe Phe Tyr Arg Lys Lys Ser Trp Tyr Ala Gly Gln
245 250 255Phe Met Arg Lys Ile Thr Pro Lys Thr Glu Ile Glu Asn Lys Ile Asp
260 265 270Leu Arg Ile Ala Asn Tyr Phe Thr Thr Leu Leu Asn Ala Leu Lys Arg
275 280 285Pro Leu Leu Ser Val Leu Val Arg Asp Ile Asp Lys Thr Phe Arg Glu
290 295 300Gln Lys Ile Gln Leu Pro Leu Lys Pro Thr Ala Lys Thr Gln Thr Leu305 310 315 320Asp Gly Ile Asp Phe Asp Phe Met His Thr Leu Ile Asn Ala Leu Met
325 330 335Lys Gln Thr Ile Gln Gly Val Ala Gln Tyr Cys Asp Ala Lys Ile Gln
340 345 350Ala Thr Lys Glu Val Ile Ser Gln Glu Ala Pro Val Gln Lys Asp Ser
355 360 365Leu Phe
370
(2) Sequence 581 data:
(i) sequence characteristics:
(A) length: 450bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 164...367
(D) Other information:
(xi) Description of the sequence: sequence 581: AATCCAGCAT GCCCTCTAAT TCAAACACGC CCTCTTCAAG CTTGTTTATG CCCTCTTGTT 60TTAAGTCGTA TTCGTCGCTA ATCTCGCCCA TGATCTCTTC AATGATGTCT TCCATAGTGA 120GCAACCCGGC TGTGCCGCCG TATTCATCAA TCACCAAAGC GGT ATG GAT TTG CTC 175
Met Asp Leu Leu
1TTT TTT CAT TTT AAT AAG GAT TTG AGA AAT GGA AGC GCT TTC GGG GAC 223Phe Phe His Phe Asn Lys Asp Leu Arg Asn Gly Ser Ala Phe Gly Asp 5 10 15 20GAT GAT CAT TTT CCT AAC GAT TTG ATT GAA ATC ATG CAT TTT GGG GGT271Asp Asp His Phe Pro Asn Asp Leu Ile Glu Ile Met His Phe Gly Gly
25 30 35AAA AAT AGA GCG CGA AAG CAA ATC CCT AAT ATG CAC CAT GCC GAT AAT 319Lys Asn Arg Ala Arg Lys Gln Ile Pro Asn Met His His Ala Asp Asn
40 45 50GTT ATC CTT AGA ACC CTT GCA ATA AGG GTA GCG CGT GAA ATG GCC TTT T 368Val Ile Leu Arg Thr Leu Ala Ile Arg Val Ala Arg Glu Met Ala Phe
55 60 65AAAACAATGT CTATATTTTC TTCATAGCTG TTTTCTTCAT CCAAACACAC CATGTCTTTT 428CGTGGGGTCA TGATTTCTTT AG 450
(2) Sequence 582 data:
(i) sequence characteristics:
(A) length: 68 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 582: met Asp Leu Leu Phe Phe His Phe Asn Lys Asp Leu Arg Asn Gly Ser 151015 Ala Phe Gly Asp Asp Asp His Phe Pro Asn Asp Leu Ile Glu Ile Met
20 25 30His Phe Gly Gly Lys Asn Arg Ala Arg Lys Gln Ile Pro Asn Met His
35 40 45His Ala Asp Asn Val Ile Leu Arg Thr Leu Ala Ile Arg Val Ala Arg
50 55 60Glu Met Ala Phe65
(2) Sequence 583 data:
(i) sequence characteristics:
(A) length: 1051bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...998
(D) Other information: (xi) Description of the sequence: sequence 583: ACCAAGAGGT CGTTAAAAGC TATTACCAAC ATTTAAAACA AGGATAAAAC ATG CAA 56
Met Gln
1GAA TTC AGT TTG TGG TGC GAT TTT ATA GAA AGG GAT TTT TTA GAA AAC 104Glu Phe Ser Leu Trp Cys Asp Phe Ile Glu Arg Asp Phe Leu Glu Asn
5 10 15GAC TTT TTA AAG CTC ATT AAT AAG GGG GCT ATT TGC GGG GCA ACG AGT 152Asp Phe Leu Lys Leu Ile Asn Lys Gly Ala Ile Cys Gly Ala Thr Ser
20 25 30AAC CCT AGT TTG TTT TGC GAA GCG ATC ACA AAA AGC GCG TTT TAT AAA 200Asn Pro Ser Leu Phe Cys Glu Ala Ile Thr Lys Ser Ala Phe Tyr Lys35 40 45 50GAT GAA ATC GCT AAA CTC AAA GGC AAA AAA GCT AAA GAA ATT TAT GAA 248Asp Glu Ile Ala Lys Leu Lys Gly Lys Lys Ala Lys Glu Ile Tyr Glu
55 60 65ACT CTG GCG TTA AAG GAT ATT TTA CAA GCT TCT AGC GCG TTG ATG CCT 296Thr Leu Ala Leu Lys Asp Ile Leu Gln Ala Ser Ser Ala Leu Met Pro
70 75 80TTA TAT GAA AAA GAC CCT AAC AAT GGC TAC ATT AGC CTA GAA ATT GAC 344LeuTyr Glu Lys Asp Pro Asn Asn Gly Tyr Ile Ser Leu Glu Ile Asp
85 90 95CCT TTT TTA GAA GAT GAT GCC GCT AAA AGC ATT GAT GAA GCC AAG CGG 392Pro Phe Leu Glu Asp Asp Ala Ala Lys Ser Ile Asp Glu Ala Lys Arg
100 105 110TTG TTC AAA ACA TTA AAC CGC CCT AAT GTG ATG ATT AAA GTC CCA GCG 440Leu Phe Lys Thr Leu Asn Arg Pro Asn Val Met Ile Lys Val Pro Ala115 120 125 130AGT GAA AGC GGG ATT GAA GTG GTT AGC GCT TTA ACT CAA GCC TCT ATT 488Ser Glu Ser Gly Ile Glu Val Val Ser Ala Leu Thr Gln Ala Ser Ile
135 140 145CCT GTT AAT GTA ACT TTA GTC TTT TCG CCT AAA ATT GCC GGT GAA ATC 536Pro Val Asn Val Thr Leu Val Phe Ser Pro Lys Ile Ala Gly Glu Ile
150 155 160GCT CAA ATC TTA GCC AAA GAA GCG CAA AAA AGA GCG GTC ATT AGC GTG 584Ala Gln Ile Leu Ala Lys Glu Ala Gln Lys Arg Ala Val Ile Ser Val
165 170 175TTT GTC TCA CGA TTT GAC AAA GAA ATA GAC CCT TTA GTG CCA AAA AAT 632Phe Val Ser Arg Phe Asp Lys Glu Ile Asp Pro Leu Val Pro Lys Asn
180 185 190TTG CAA GCT CAA AGC GGG ATT ATC AAC GCT ACC GAG TGC TAT TAT CAA 680Leu Gln Ala Gln Ser Gly Ile Ile Asn Ala Thr Glu Cys Tyr Tyr Gln195 200 205 210ATT AAT CAG CAT GCC AAT AAG CTA ACA AGC ACC CTT TTT GCA TCC ACA 728Ile Asn Gln His Ala Asn Lys Leu Thr Ser Thr Leu Phe Ala Ser Thr
215 220 225GGC GTT AAA TCC AAT TCT TTA GCT AAA GAT TAC TAC ATT AAA GCG CTG 776Gly Val Lys Ser Asn Ser Leu Ala Lys Asp Tyr Tyr Ile Lys Ala Leu
230 235 240TGT TTT AAA AAC TCT ATC AAT ACA GCC CCT CTA GAG GCT TTA AAC GCT 824Cys Phe Lys Asn Ser Ile Asn Thr Ala Pro Leu Glu Ala Leu Asn Ala
245 250 255TAT TTG CTT GAC CCA AAC ACC GAG TGT CAA ACC CCT TTA AAG ACT ACA 872Tyr Leu Leu Asp Pro Asn Thr Glu Cys Gln Thr Pro Leu Lys Thr Thr
260 265 270GAA ATT GAA GCG TTT AAA AAA GAA TTA AAA GTG CAC AAC ATT GAT TTA 920Glu Ile Glu Ala Phe Lys Lys Glu Leu Lys Val His Asn Ile Asp Leu275 280 285 290GAA AAC ACC GCT CAA AAA CTC CTT AAA GAA GGC TTG ATA GCG TTC AAA 968Glu Asn Thr Ala Gln Lys Leu Leu Lys Glu Gly Leu Ile Ala Phe Lys
295 300 305CAA TCC TTT GAA AAG CTT TTA AGC AGT TTT TGATTTTTAA GGGTTTTTTG GAT 1021Gln Ser Phe Glu Lys Leu Leu Ser Ser Phe
310 315AGAATAAGCC CTTATTTTAT TTTAAAGGAT 1051
(2) Sequence 584 data:
(i) sequence characteristics:
(A) length: 316 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 584: met Gln Glu Phe Ser Leu Trp Cys Asp Phe Ile Glu Arg Asp Phe Leu 151015 Glu Asn Asp Phe Leu Lys Leu Ile Asn Lys Gly Ala Ile Cys Gly Ala
20 25 30Thr Ser Asn Pro Ser Leu Phe Cys Glu Ala Ile Thr Lys Ser Ala Phe
35 40 45Tyr Lys Asp Glu Ile Ala Lys Leu Lys Gly Lys Lys Ala Lys Glu Ile
50 55 60Tyr Glu Thr Leu Ala Leu Lys Asp Ile Leu Gln Ala Ser Ser Ala Leu65 70 75 80Met Pro Leu Tyr Glu Lys Asp Pro Asn Asn Gly Tyr Ile Ser Leu Glu
85 90 95Ile Asp Pro Phe Leu Glu Asp Asp Ala Ala Lys Ser Ile Asp Glu Ala
100 105 110Lys Arg Leu Phe Lys Thr Leu Asn Arg Pro Asn Val Met Ile Lys Val
115 120 125Pro Ala Ser Glu Ser Gly Ile Glu Val Val Ser Ala Leu Thr Gln Ala
130 135 140Ser Ile Pro Val Asn Val Thr Leu Val Phe Ser Pro Lys Ile Ala Gly145 150 155 160Glu Ile Ala Gln Ile Leu Ala Lys Glu Ala Gln Lys Arg Ala Val Ile
165 170 175Ser Val Phe Val Ser Arg Phe Asp Lys Glu Ile Asp Pro Leu Val Pro
180 185 190Lys Asn Leu Gln Ala Gln Ser Gly Ile Ile Asn Ala Thr Glu Cys Tyr
195 200 205Tyr Gln Ile Asn Gln His Ala Asn Lys Leu Thr Ser Thr Leu Phe Ala
210 215 220Ser Thr Gly Val Lys Ser Asn Ser Leu Ala Lys Asp Tyr Tyr Ile Lys225 230 235 240Ala Leu Cys Phe Lys Asn Ser Ile Asn Thr Ala Pro Leu Glu Ala Leu
245 250 255Asn Ala Tyr Leu Leu Asp Pro Asn Thr Glu Cys Gln Thr Pro Leu Lys
260 265 270Thr Thr Glu Ile Glu Ala Phe Lys Lys Glu Leu Lys Val His Asn Ile
275 280 285Asp Leu Glu Asn Thr Ala Gln Lys Leu Leu Lys Glu Gly Leu Ile Ala
290 295 300Phe Lys Gln Ser Phe Glu Lys Leu Leu Ser Ser Phe305 310 315
(2) Sequence 585 data:
(i) sequence characteristics:
(A) length: 1254bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 55...1215
(D) Other information:
(xi) Description of the sequence: sequence 585: AGCTATAATA AAATAATTAA AAAAGTAACA CTTAAGCGGA GACCCTAGAG AGTG ATG 57
Met
1CTC AAT TTT ATG ACA AAG AAG AAA AAT AGA ATG CAA GAT TGC AAA ATG 105Leu Asn Phe Met Thr Lys Lys Lys Asn Arg Met Gln Asp Cys Lys Met
5 10 15GTG TGT AAA AAT TTT AAT CGT AAG GAA TCT GTT TTG ATA GCT CAA TCT 153VaT Cys Lys Asn Phe Asn Arg Lys Glu Ser Val Leu Ile Ala Gln Ser
20 25 30TTA GAT ATT TCT AAA AAA GGT TCG GTA ATT TTA GGC GCT CTT TTG AGT 201Leu Asp Ile Ser Lys Lys Gly Ser Val Ile Leu Gly Ala Leu Leu Ser
35 40 45TCG TTA TGG CTG ACA AAC CCC TTA AAT GCC CAT GAA AAG AAT GGC GCG 249Ser Leu Trp Leu Thr Asn Pro Leu Asn Ala His Glu Lys Asn Gly Ala50 55 60 65TTT GTG GGG ATT AGC TTG GAA GTG GGT AGG GCC GAT CAA AAG ACA AAC 297Phe Val Gly Ile Ser Leu Glu Val Gly Arg Ala Asp Gln Lys Thr Asn
70 75 80GCT TAT AAA AAC GGC GAG TTG TTT CAA GTG CCT TTT GGC GAT GTT TCG 345Ala Tyr Lys Asn Gly Glu Leu Phe Gln Val Pro Phe Gly Asp Val Ser
85 90 95GCT AAT GAT GAT GGC AAA GTT CCT GAC GGG CAG ACC GGT GGC TGT CAG 393Ala Asn Asp Asp Gly Lys Val Pro Asp Gly Gln Thr Gly Gly Cys Gln
100 105 110CCA GCT TCA GGG ACG CCA GGA ACG CCA GGC TAC ACT AAA GCT AAC TGC 441Pro Ala Ser Gly Thr Pro Gly Thr Pro Gly Tyr Thr Lys Ala Asn Cys
115 120 125GTG GTC AAT TGG ACT TCG CGC ACC ATG CTT AGC ACC AAT AAA AAC ATT 489Val Val Asn Trp Thr Ser Arg Thr Met Leu Ser Thr Asn Lys Asn Ile130 135 140 145CCT GGC CGT AAC CAG CCG ATG TAT GGG CTA GGC GTG ATG ACA GGC TAT 537Pro Gly Arg Asn Gln Pro Met Tyr Gly Leu Gly Val Met Thr Gly Tyr
150 155 160AAG CAT TTT ATC GGT AAA AAA AGA TGG TTT GGG TTG CGC TAT TAC GGC 585Lys His Phe Ile Gly Lys Lys Arg Trp Phe Gly Leu Arg Tyr Tyr Gly
165 170 175TTT TTT GAT TAT GGG CAT ACC AAT TTC TCT AAC TCC AGA GCC GCT AAC 633Phe Phe Asp Tyr Gly His Thr Asn Phe Ser AsnSer Arg Ala Ala Asn
180 185 190GCT ATA TCG CCT TTT TAT TTG AGC GAT CAA AAA GCC GAC ATG TAT ACT 681Ala Ile Ser Pro Phe Tyr Leu Ser Asp Gln Lys Ala Asp Met Tyr Thr
195 200 205TAT GGT TTT GGC ACA GAC ATG CTT TTT AAC ATT ATA GAT AAG CCT AAA 729Tyr Gly Phe Gly Thr Asp Met Leu Phe Asn Ile Ile Asp Lys Pro Lys210 215 220 225GCC ACG GCC GGG TTT TTT TTA GGC GTG AAT TTT GCG GGT AAC ACT TGG 777Ala Thr Ala Gly Phe Phe Leu Gly Val Asn Phe Ala Gly Asn Thr Trp
230 235 240ACT AAT AAT CGT GTG GGG TAT TTT AAG GAC GGG TAT GTT TAT GGC GTC 825Thr Asn Asn Arg Val Gly Tyr Phe Lys Asp Gly Tyr Val Tyr Gly Val
245 250 255AAT ACG GAC GCT GAC GCT TAC ATG ACT AAC GCT GAT GGC ACA ATC ACT 873Asn Thr Asp Ala Asp Ala Tyr Met Thr Asn Ala Asp Gly Thr Ile Thr
260 265 270TGC GGG GAC ACG ACG CCG GCG AGT TGC AAT GTG GGG ATT AAC CCT AAT 921Cys Gly Asp Thr Thr Pro Ala Ser Cys Asn Val Gly Ile Asn Pro Asn
275 280 285AGC GTC TAT ACC ACA GGA AAA TTG AAC GCT AAG GTG AAT CAC ACG ATT 969Ser Val Tyr Thr Thr Gly Lys Leu Asn Ala Lys Val Asn His Thr Ile290 295 300 305TTC CAA TTT TTA GTG AAT GTG GGC ATT AGA ACT AAT ATT TTT GAA CAC 1017Phe Gln Phe Leu Val Asn Val Gly Ile Arg Thr Asn Ile Phe Glu His
310 315 320CAT GGC ATT GAG TTT GGC ATC AAA ATC CCC ACG CTC CCT AAC TAC TTT 1065His Gly Ile Glu Phe Gly Ile Lys Ile Pro Thr Leu Pro Asn Tyr Phe
325330 335TTC AAA GGT TCT ACT ACC ATA AGA GCG AAA AAA CAA GGC CCG CTA GAG 1113Phe Lys Gly Ser Thr Thr Ile Arg Ala Lys Lys Gln Gly Pro Leu Glu
340 345 350AAT GGC CAA CCA ACC ACT ATC ACC GGA GCA GAA ACC AAT TTC AGC TTA 1161Asn Gly Gln Pro Thr Thr Ile Thr Gly Ala Glu Thr Asn Phe Ser Leu
355 360 365ACC CAA ACC TTA CGC CGT CAG TAT TCT ATG TAT TTG CGC TAT GTT TAT 1209Thr Gln Thr Leu Arg Arg Gln Tyr Ser Met Tyr Leu Arg Tyr Val Tyr370 375 380 385ACT TTT TAAGTTTGGT AGGGTTTTTA GGCAAGGCTT AGAGATGAA 1254Thr Phe
(2) Data in sequence 586:
(i) sequence characteristics:
(A) length: 387 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 586: met Leu Asn Phe Met Thr Lys Lys Lys Asn Arg Met Gln Asp Cys Lys 151015 Met Val Cys Lys Asn Phe Asn Arg Lys Glu Ser Val Leu Ile Ala Gln
20 25 30Ser Leu Asp Ile Ser Lys Lys Gly Ser Val Ile Leu Gly Ala Leu Leu
35 40 45 Ser Ser Leu Trp Leu Thr Asn Pro Leu Asn Ala His Glu Lys Asn Gly
50 55 60Ala Phe Val Gly Ile Ser Leu Glu Val Gly Arg Ala Asp Gln Lys Thr65 70 75 80Asn Ala Tyr Lys Asn Gly Glu Leu Phe GlnVal Pro Phe Gly Asp Val
85 90 95Ser Ala Asn Asp Asp Gly Lys Val Pro Asp Gly Gln Thr Gly Gly Cys
100 105 110Gln Pro Ala Ser Gly Thr Pro Gly Thr Pro Gly Tyr Thr Lys Ala Asn
115 120 125Cys Val Val Asn Trp Thr Ser Arg Thr Met Leu Ser Thr Asn Lys Asn
130 135 140Ile Pro Gly Arg Asn Gln Pro Met Tyr Gly Leu Gly Val Met Thr Gly145 150 155 160Tyr Lys His Phe Ile Gly Lys Lys Arg Trp Phe Gly Leu Arg Tyr Tyr
165 170 175Gly Phe Phe Asp Tyr Gly His Thr Asn Phe Ser Asn Ser Arg Ala Ala
180 185 190Asn Ala Ile Ser Pro Phe Tyr Leu Ser Asp Gln Lys Ala Asp Met Tyr
195 200 205Thr Tyr Gly Phe Gly Thr Asp Met Leu Phe Asn Ile Ile Asp Lys Pro
210 215 220Lys Ala Thr Ala Gly Phe Phe Leu Gly Val Asn Phe Ala Gly Asn Thr225 230 235 240Trp Thr Asn Asn Arg Val Gly Tyr Phe Lys Asp Gly Tyr Val Tyr Gly
245 250 255Val Asn Thr Asp Ala Asp Ala Tyr Met Thr Asn Ala Asp Gly Thr Ile
260 265 270Thr Cys Gly Asp Thr Thr Pro Ala Ser Cys Asn Val Gly Ile Asn Pro
275 280 285Asn Ser Val Tyr Thr Thr Gly Lys Leu Asn Ala Lys Val Asn His Thr
290 295 300Ile Phe Gln Phe Leu Val Asn Val Gly Ile Arg Thr Asn Ile Phe Glu305 310 315 320His His Gly Ile Glu Phe Gly Ile Lys Ile Pro Thr Leu Pro Asn Tyr
325 330 335Phe Phe Lys Gly Ser Thr Thr Ile Arg Ala Lys Lys Gln Gly Pro Leu
340 345 350Glu Asn Gly Gln Pro Thr Thr Ile Thr Gly Ala Glu Thr Asn Phe Ser
355 360 365Leu Thr Gln Thr Leu Arg Arg Gln Tyr Ser Met Tyr Leu Arg Tyr Val
370 375 380Tyr Thr Phe385
(2) Sequence 587 data: (i) sequence characteristics: length (A): 534bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 481 (D) other information: (xi) Description of the sequence: sequence 587: AGTAGATTAA AAACTCTTTA ATTTTCCCAT GAATAAAGGA TTTTAA ATG GAT GCG 55
Met Asp Ala
1ATT TAT CCT TAT GTG TTG GTT GTT CAT TTA TTG TGC GCC ATT ATT TTT 103Ile Tyr Pro Tyr Val Leu Val Val His Leu Leu Cys Ala Ile Ile Phe
5 10 15ATT GGC TAC TTG TTT TTT GAT GGG GTA ATT TTC CCT AAT GTG AAG AAA 151Ile Gly Tyr Leu Phe Phe Asp Gly Val Ile Phe Pro Asn Val Lys Lys20 25 30 35ATG TTT GGC GAA GAG TTT GCC AAT AAA GCG AAT ACA GGA ATC ACT CAA 199Met Phe Gly Glu Glu Phe Ala Asn Lys Ala Asn Thr Gly Ile Thr Gln
40 45 50AGA GCG ATC AAA ATC ATG CCC TTA TGC GTT TTA GGG CTT GTT TTA ACA 247Arg Ala Ile Lys Ile Met Pro Leu Cys Val Leu Gly Leu Val Leu Thr
55 60 65GGG GGC ATG ATG CTT AGC CAA TAC ATG GGG GGC GAT AAA GGC TGG TGT 295Gly Gly Met Met Leu Ser Gln Tyr Met Gly Gly Asp Lys Gly Trp Cys
70 75 80GAA ACC CCT TTT CAA AAG ATA CTC ATG CTT AAA GTG ATC TTA GCG TTA 343Glu Thr Pro Phe Gln Lys Ile Leu Met Leu Lys Val Ile Leu Ala Leu
85 90 95AGC ATT TTT CTT TTG GTG CTT TTT TCT TTA TCG TGT AAG TTT TTG GGC 391Ser Ile Phe Leu Leu Val Leu Phe Ser Leu Ser Cys Lys Phe Leu Gly100 105 110 115AAG AAA AAC CCT ATT GGT AAA TAT ATC CAC CCT ATC GCT CTA ACT TTT 439Lys Lys Asn Pro Ile Gly Lys Tyr Ile His Pro Ile Ala Leu Thr Phe
120 125 130GGC TTT TTA ATC GCC ATT TTA GCC AAA ACG ATG TGG TTT GTT TAAGAGCGT 490Gly Phe Leu Ile Ala Ile Leu Ala Lys Thr Met Trp Phe Val
135 140 145TTCAACCTCA AAGAATTTAA GACCACTAAG AGTGAGCTAG CGCT 534
(2) Sequence 588 data: (i) sequence characteristics: length (A): 145 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 588: met Asp Ala Ile Tyr Pro Tyr Val Leu Val Val His Leu Leu Cys Ala 151015 Ile Ile Phe Ile Gly Tyr Leu Phe Phe Asp Gly Val Ile Phe Pro Asn
20 25 30Val Lys Lys Met Phe Gly Glu Glu Phe Ala Asn Lys Ala Asn Thr Gly
35 40 45Ile Thr Gln Arg Ala Ile Lys Ile Met Pro Leu Cys Val Leu Gly Leu
50 55 60Val Leu Thr Gly Gly Met Met Leu Ser Gln Tyr Met Gly Gly Asp Lys65 70 75 80Gly Trp Cys Glu Thr Pro Phe Gln Lys Ile Leu Met Leu Lys Val Ile
85 90 95Leu Ala Leu Ser Ile Phe Leu Leu Val Leu Phe Ser Leu Ser Cys Lys
100 105 110Phe Leu Gly Lys Lys Asn Pro Ile Gly Lys Tyr Ile His Pro Ile Ala
115 120 125Leu Thr Phe Gly Phe Leu Ile Ala Ile Leu Ala Lys Thr Met Trp Phe
130 135 140Val145
(2) Sequence 589 data: (i) sequence characteristics: length (A): 635bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 48...584
(D) Other information: (xi) Description of the sequence: sequence 589: ACCACCTCAC CGATGAAGAA ATTAAGATCA TTGAAGAGGG GCAGTGA ATG GAA AAG 56
Met Glu Lys
1TTA TTT GAA AAG ATA TTG CAT GAA ATG AGA TCA AGA ACT TCT TTT CTG 104Leu Phe Glu Lys Ile Leu His Glu Met Arg Ser Arg Thr Ser Phe Leu
5 10 15CTT GCT TTT GTC GTT TCG CTT ATT GTT TTT ATT TTT AAT CTA AAA GGG 152Leu Ala Phe Val Val Ser Leu Ile Val Phe Ile Phe Asn Leu Lys Gly20 25 30 35GTT TTT CAA TTG ATT TTT GAG TCT ATT TTC CAA TAC ACC CAA AAC AAA 200Val Phe Gln Leu Ile Phe Glu Ser Ile Phe Gln Tyr Thr Gln Asn Lys
40 45 50ATC CTT TCT TTT TCT CTT TCT TTT TTC TTT ATT TTC TTT TTC TTT TAC 248Ile Leu Ser Phe Ser Leu Ser Phe Phe Phe Ile Phe Phe Phe Phe Tyr
55 60 65GCT ATT TTT CTT ATT TTT TAT CAA ATA TTT CTT TGG TAT GGG GCT AAA 296Ala Ile Phe Leu Ile Phe Tyr Gln Ile Phe Leu Trp Tyr Gly Ala Lys
70 75 80AAA TAT AAA CAA AAT CAA AGA GAT AGT GAA ATT GTC TAT AAC ATT CAA 344Lys Tyr Lys Gln Asn Gln Arg Asp Ser Glu Ile Val Tyr Asn Ile Gln
85 90 95AAA TTC CCA AAT GAG ATA AAA GAA GAA CTT TAT CGT TGC TAT TCT AAA 392Lys Phe Pro Asn Glu Ile Lys Glu Glu Leu Tyr Arg Cys Tyr Ser Lys100 105 110 115AAA CAA AAT AAA ATT CTT AGA ACG AAA AAA CTT GAT GAT TTG ATA GAT 440Lys Gln Asn Lys Ile Leu Arg Thr Lys Lys Leu Asp Asp Leu Ile Asp
120 125 130TAT CTT GAT TTA ATA GGT TTT TTT AAG TCG AGA GAT TTT TTT GAA CCG 488Tyr Leu Asp Leu Ile Gly Phe Phe Lys Ser Arg Asp Phe Phe Glu Pro
135 140 145ACA AAA GAC GAT TAT ATT GTC AAA CCG GAT GTC TTA AGG GCT ATA AAA 536Thr Lys Asp Asp Tyr Ile Val Lys Pro Asp Val Leu Arg Ala Ile Lys
150 155 160AAA TAC CAT AAA ATT GCT TTT AAA TCT GTA TAT TGG CAA CAG AAC AAA T 585Lys Tyr His Lys Ile Ala Phe Lys Ser Val Tyr Trp Gln Gln Asn Lys
165 170 175AAAAAGCGCT TGTTCTTTGT CTAAGAAACA CCCCCCTTTA AAAAAGGGGG 635
(2) Sequence 590 data: (i) sequence characteristics: length (A): 179 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 590: met Glu Lys Leu Phe Glu Lys Ile Leu His Glu Met Arg Ser Arg Thr 151015 Ser Phe Leu Leu Ala Phe Val Val Ser Leu Ile Val Phe Ile Phe Asn
20 25 30Leu Lys Gly Val Phe Gln Leu Ile Phe Glu Ser Ile Phe Gln Tyr Thr
35 40 45Gln Asn Lys Ile Leu Ser Phe Ser Leu Ser Phe Phe Phe Ile Phe Phe
50 55 60Phe Phe Tyr Ala Ile Phe Leu Ile Phe Tyr Gln Ile Phe Leu Trp Tyr65 70 75 80Gly Ala Lys Lys Tyr Lys Gln Asn Gln Arg Asp Ser Glu Ile Val Tyr
85 90 95Asn Ile Gln Lys Phe Pro Asn Glu Ile Lys Glu Glu Leu Tyr Arg Cys
100 105 110Tyr Ser Lys Lys Gln Asn Lys Ile Leu Arg Thr Lys Lys Leu Asp Asp
115 120 125Leu Ile Asp Tyr Leu Asp Leu Ile Gly Phe Phe Lys Ser Arg Asp Phe
130 135 140Phe Glu Pro Thr Lys Asp Asp Tyr Ile Val Lys Pro Asp Val Leu Arg145 150 155 160Ala Ile Lys Lys Tyr His Lys Ile Ala Phe Lys Ser Val Tyr Trp Gln
165 170 175Gln Asn Lys
(2) Sequence 591 data:
(i) sequence characteristics:
(A) length: 292bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...239
(D) Other information:
(xi) Description of the sequence: sequence 591: TTGCCCTTTT CAAAAATATA ATAGCTGTAT TTTAAAAGCT CTATCCATAG CCT GAG 56
Pro Glu
1CTT GGT GAT TTC GCA AGA ATT GGG GTT AAT ATC CAC GCC AAA AAG GCA 104Leu Gly Asp Phe Ala Arg Ile Gly Val Asn Ile His Ala Lys Lys Ala
5 10 15GTT TTC AAT AAT GGA TTT TTT AAG ATT AAA AAG TTC TTT TTG GAT GTG 152Val Phe Asn Asn Gly Phe Phe Lys Ile Lys Lys Phe Phe Leu Asp Val
20 25 30GTG GTG GGG GTC GTT TTC GCT ATC TGG TTT TAT GTA GTT AAA GAT TTC 200Val Val Gly Val Val Phe Ala Ile Trp Phe Tyr Val Val Lys Asp Phe35 40 45 50ACC CGT TGG CGT GTG GTG AAT GAT GAT TTC ATC GTT TTC TAATTTAAGA TC 251Thr Arg Trp Arg Val Val Asn Asp Asp Phe Ile Val Phe
55 60GTAGCGATAC AAGGAAGCAA TAAGTCCTAG CTCATAAGCA A 292
(2) Sequence 592 data:
(i) sequence characteristics:
(A) length: 63 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 592: pro Glu Leu Gly Asp Phe Ala Arg Ile Gly Val Asn Ile His Ala Lys 151015 Lys Ala Val Phe Asn Asn Gly Phe Phe Lys Ile Lys Lys Phe Phe Leu
20 25 30Asp Val Val Val Gly Val Val Phe Ala Ile Trp Phe Tyr Val Val Lys
35 40 45Asp Phe Thr Arg Trp Arg Val Val Asn Asp Asp Phe Ile Val Phe
50 55 60
(2) Sequence 593 data:
(i) sequence characteristics:
(A) length: 340bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...287
(D) Other information: (xi) Description of the sequence: sequence 593: TAATTTAATA GTTTAGCTAT CATGGAGCAT TCTAAATTAA AGGCGATCAC ATG TTT 56
Met Phe
1GAA AAA ATA CGC AAG ATT TTA GCG GAT ATT GAA GAT TCG CAA AAT GAA 104Glu Lys Ile Arg Lys Ile Leu Ala Asp Ile Glu Asp Ser Gln Asn Glu
5 10 15ATT GAA ATG CTTTTA AAA TTA GCG AAT TTG AGT TTG GGG GAT TTT ATT 152Ile Glu Met Leu Leu Lys Leu Ala Asn Leu Ser Leu Gly Asp Phe Ile
20 25 30GAG ATT AAA AGA GGG AGC ATG GAC ATG CCA AAG GGC GTG AAT GAA GCG 200Glu Ile Lys Arg Gly Ser Met Asp Met Pro Lys Gly Val Asn Glu Ala35 40 45 50TTT TTT ACG CAA TTA AGC GAA GAA GTG GAG CGA TTG AAG GAG CTT ATT 248Phe Phe Thr Gln Leu Ser Glu Glu Val Glu Arg Leu Lys Glu Leu Ile
55 60 65AAC GCT TTG AAT AAA ATC AAA AAA GGG TTA TTG GTG TTT TAAATGTGTG GG 299Asn Ala Leu Asn Lys Ile Lys Lys Gly Leu Leu Val Phe
70 75ATTGTAGGTT ATATAGGGGA TAGCGAGAAA AAATCCGTTC T 340
(2) Sequence 594 data:
(i) sequence characteristics:
(A) length: 79 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 594: met Phe Glu Lys Ile Arg Lys Ile Leu Ala Asp Ile Glu Asp Ser Gln 151015 Asn Glu Ile Glu Met Leu Leu Lys Leu Ala Asn Leu Ser Leu Gly Asp
20 25 30Phe Ile Glu Ile Lys Arg Gly Ser Met Asp Met Pro Lys Gly Val Asn
35 40 45Glu Ala Phe Phe Thr Gln Leu Ser Glu Glu Val Glu Arg Leu Lys Glu
50 55 60Leu Ile Asn Ala Leu Asn Lys Ile Lys Lys Gly Leu Leu Val Phe65 70 75
(2) Data for sequence 595: (i) sequence characteristics: length (A): 3101bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 3050 (D) other information: (xi) Description of the sequence: sequence 595: GGGGGGCGTT GTTAATCAAT GAGCAAGAAA AGAAAATTGA AAATAAATAG GGA ATG 56
Met
1ATC CAA TCC AGC CTT TAT AGA GCC TTA AAC AAA GGC TTT GAT TAC CAA 104Ile Gln Ser Ser Leu Tyr Arg Ala Leu Asn Lys Gly Phe Asp Tyr Gln
5 10 15ATA CTC GCT TGT AAG GAT TTT AAA GAA TCC GAG CTC GCT AAA GAA GTC 152Ile Leu Ala Cys Lys Asp Phe Lys Glu Ser Glu Leu Ala Lys Glu Val
20 25 30ATA AGC TAT TTT AAG CCA AAT ACC AAA GCC ATT CTT TTC CCG GAG TTT 200Ile Ser Tyr Phe Lys Pro Asn Thr Lys Ala Ile Leu Phe Pro Glu Phe
35 40 45AGG GCT AAA AAA AAC GAC GAT TTG CGT TCG TTT TTT GAA GAA TTT TTA 248Arg Ala Lys Lys Asn Asp Asp Leu Arg Ser Phe Phe Glu Glu Phe Leu50 55 60 65CAG CTT TTA GGG GGT TTA AGG GAG TTT TAT CAA GCC TTA GAA AAC AAG 296Gln Leu Leu Gly Gly Leu Arg Glu Phe Tyr Gln Ala Leu Glu Asn Lys
70 75 80CAA GAA ACT ATC ATC ATT GCC CCG ATT AGC GCG TTA TTG CAC CCT TTA 344Gln Glu Thr Ile Ile Ile Ala Pro Ile Ser Ala Leu Leu His Pro Leu
85 90 95CCT AAA AAA GAA CTT TTAGAA AGC TTT AAA ATC ACT CTT TTA GAA AAA 392Pro Lys Lys Glu Leu Leu Glu Ser Phe Lys Ile Thr Leu Leu Glu Lys
100 105 110TAT AAC CTT AAG GAT TTG AAA GAC AAG CTC TTT TAT TAT GGC TAT GAA 440Tyr Asn Leu Lys Asp Leu Lys Asp Lys Leu Phe Tyr Tyr Gly Tyr Glu
115 120 125ATT TTA GAC TTA GTG GAA GTG GAA GGC GAA GCG AGC TTT AGG GGG GAT 488Ile Leu Asp Leu Val Glu Val Glu Gly Glu Ala Ser Phe Arg Gly Asp130 135 140 145ATT GTG GAT ATT TAT GCG CCA AAT TCT AAA GCG TAT CGC TTG AGT TTT 536Ile Val Asp Ile Tyr Ala Pro Asn Ser Lys Ala Tyr Arg Leu Ser Phe
150 155 160TTT GAC ACC GAG TGT GAG AGC ATT AAG GAA TTT GAT CCC ATT ACT CAA 584Phe Asp Thr Glu Cys Glu Ser Ile Lys Glu Phe Asp Pro Ile Thr Gln
165 170 175ATG AGC CTT AAA GAA GAT TTG TTA GAA ATT GAA ATC CCC CCC ACG CTT 632Met Ser Leu Lys Glu Asp Leu Leu Glu Ile Glu Ile Pro Pro Thr Leu
180 185 190TTT AGT TTG GAC GAA TCA TCT TAT AAG GAT CTA AAA ACA AAA GTG GAA 680Phe Ser Leu Asp Glu Ser Ser Tyr Lys Asp Leu Lys Thr Lys Val Glu
195 200 205CAA AGC CCC TTA AAT AGC TTT TCT AAA GAT TTA ACC AGT TTT GGT TTG 728Gln Ser Pro Leu Asn Ser Phe Ser Lys Asp Leu Thr Ser Phe Gly Leu210 215 220 225TGG TTT TTA GGA GAA AAA GCA CAA GAC TTA CTA ATC GTT TAT AAA AGC 776Trp Phe Leu Gly Glu Lys Ala Gln Asp Leu Leu Ile Val Tyr Lys Ser
230 235 240ATT ATA AGT CCT AGA GCT TTA GAA GAA ATT CAA GAA TTA GCG AGC TTA 824Ile Ile Ser Pro Arg Ala Leu Glu GluIle Gln Glu Leu Ala Ser Leu
245 250 255AAC GAA TTG GAT TGT GAG CGT TTC AAA TTT TTA AAG GTT TTA GAA AAC 872Asn Glu Leu Asp Cys Glu Arg Phe Lys Phe Leu Lys Val Leu Glu Asn
260 265 270GCG CAA GGC TAT GAA GAT TTA GAA ATC CAT GCG CAT GCC CTA GAA GGC 920Ala Gln Gly Tyr Glu Asp Leu Glu Ile His Ala His Ala Leu Glu Gly
275 280 285TTT ATC GCT TTG CAT TCA AAT CAT AAA ATC ACG CTC CTA GCC CCC AAT 968Phe Ile Ala Leu His Ser Asn His Lys Ile Thr Leu Leu Ala Pro Asn290 295 300 305AAA ACG ATT TTA GAC AAC GCG ATA AGC GCG CTT GAT GCA GGC AAC ATG 1016Lys Thr Ile Leu Asp Asn Ala Ile Ser Ala Leu Asp Ala Gly Asn Met
310 315 320GAA TGC GTC ATC GCC CCC TTT GTG TTA AAC TTT AAA ACC CCT GAT GGG 1064Glu Cys Val Ile Ala Pro Phe Val Leu Asn Phe Lys Thr Pro Asp Gly
325 330 335ATT TTT ATT TCG CTC AAT TCT TTT GAA AGG AAG AAA AAA CGC CAA AAA 1112Ile Phe Ile Ser Leu Asn Ser Phe Glu Arg Lys Lys Lys Arg Gln Lys
340 345 350TCC AAG CTC GCT TTG AAT GAG TTG AAT CCG GGC GAA TGG GTG GTG CAT 1160Ser Lys Leu Ala Leu Asn Glu Leu Asn Pro Gly Glu Trp Val Val His
355 360 365GAT GAT TAT GGG GTG GGC GTG TTT TCT CAA TTA GTC CAG CAC AGC GTT 1208Asp Asp Tyr Gly Val Gly Val Phe Ser Gln Leu Val Gln His Ser Val370 375 380 385TTA GGG AGC AAG AGG GAT TTT TTA GAA ATC GCT TAT TTG GGC GAA GAC 1256Leu Gly Ser Lys Arg Asp Phe Leu Glu Ile Ala Tyr Leu Gly Glu Asp
390 395400AAA CTG CTG TTA CCG GTA GAA AAC TTG CAT CTC ATC GCT CGC TAT GTG 1304Lys Leu Leu Leu Pro Val Glu Asn Leu His Leu Ile Ala Arg Tyr Val
405 410 415GCG CAA AGC GAT AGC GTG CCA GCT AAA GAC CGG CTA GGG AAA GGG AGC 1352Ala Gln Ser Asp Ser Val Pro Ala Lys Asp Arg Leu Gly Lys Gly Ser
420 425 430TTT CTT AAA TTA AAA GCT AAA GTC AGG ACT AAG CTT TTA GAG ATT GCT 1400Phe Leu Lys Leu Lys Ala Lys Val Arg Thr Lys Leu Leu Glu Ile Ala
435 440 445AGC AAG ATC ATT GAA TTA GCG GCT GAA CGC AAT TTG ATC TTG GGT AAA 1448Ser Lys Ile Ile Glu Leu Ala Ala Glu Arg Asn Leu Ile Leu Gly Lys450 455 460 465AAG ATG GAT GTG CAT TTA GCG GAG TTG GAA GTC TTT AAA TCG CAT GCG 1496Lys Met Asp Val His Leu Ala Glu Leu Glu Val Phe Lys Ser His Ala
470 475 480GGG TTT GAA TAC ACC AGC GAT CAA GAA AAG GCT ATC GCT GAA ATT TCA 1544Gly Phe Glu Tyr Thr Ser Asp Gln Glu Lys Ala Ile Ala Glu Ile Ser
485 490 495AAG GAT TTA AGC TCT CAC AGG GTG ATG GAT AGA TTA TTG AGT GGG GAT 1592Lys Asp Leu Ser Ser His Arg Val Met Asp Arg Leu Leu Ser Gly Asp
500 505 510GTG GGT TTT GGG AAA ACA GAA GTG GCG ATG CAT GCG ATT TTT TGC GCG 1640Val Gly Phe Gly Lys Thr Glu Val Ala Met His Ala Ile Phe Cys Ala
515 520 525TTT TTG AAC GGC TTT CAA AGC GCT TTA GTT GTG CCT ACC ACT TTA TTA 1688Phe Leu Asn Gly Phe Gln Ser Ala Leu Val Val Pro Thr Thr Leu Leu530 535 540 545GCG CAC CAG CAT TTT GAG ACT TTA AGG GCG CGT TTT GAA AAT TTT GGC 1736Ala HisGln His Phe Glu Thr Leu Arg Ala Arg Phe Glu Asn Phe Gly
550 555 560GTT AAA GTG GCT CGT TTG GAC AGG TAT GCG AGC GAA AAA AAC AAG CTT 1784Val Lys Val Ala Arg Leu Asp Arg Tyr Ala Ser Glu Lys Asn Lys Leu
565 570 575TTA AAG GCG GTG GAA TTA GGG CAA GTT GAT GCG CTA ATA GGC ACG CAT 1832Leu Lys Ala Val Glu Leu Gly Gln Val Asp Ala Leu Ile Gly Thr His
580 585 590GCG ATT TTA GGC GCG AAA TTC AAA AAC CTG GGC TTG GTG GTG GTG GAT 1880Ala Ile Leu Gly Ala Lys Phe Lys Asn Leu Gly Leu Val Val Val Asp
595 600 605GAA GAG CAT AAA TTT GGC GTG AAA CAA AAA GAA GCT TTA AAA GAA TTG 1928Glu Glu His Lys Phe Gly Val Lys Gln Lys Glu Ala Leu Lys Glu Leu610 615 620 625AGT AAG AGC GTG CAT TTT TTA AGC ATG TCC GCT ACG CCT ATC CCG CGC 1976Ser Lys Ser Val His Phe Leu Ser Met Ser Ala Thr Pro Ile Pro Arg
630 635 640ACT CTA AAC ATG GCG CTC TCT CAA ATT AAG GGC ATT AGT TCT TTA AAA 2024Thr Leu Asn Met Ala Leu Ser Gln Ile Lys Gly Ile Ser Ser Leu Lys
645 650 655ACC CCG CCC ACA GAC AGA AAG CCC AGC CGC ACT TTT TTG AAA GAA AAG 2072Thr Pro Pro Thr Asp Arg Lys Pro Ser Arg Thr Phe Leu Lys Glu Lys
660 665 670AAT GAC GAA CTC TTA AAA GAG ATT ATT TAC AGA GAA TTA CGC CGT AAC 2120Asn Asp Glu Leu Leu Lys Glu Ile Ile Tyr Arg Glu Leu Arg Arg Asn
675 680 685GGG CAA ATT TTT TAC ATC CAT AAC CAC ATC GCT AGC ATT TTA AAA GTC 2168Gly Gln Ile Phe Tyr Ile His Asn His Ile Ala Ser Ile Leu Lys Val690 695 700 705AAA ACC AAG CTA GAA GAT TTA ATC CCT AAA CTC AAA ATC GCT ATT TTG 2216Lys Thr Lys Leu Glu Asp Leu Ile Pro Lys Leu Lys Ile Ala Ile Leu
710 715 720CAT TCC CAG ATT AAC GCT AAT GAG AGC GAA GAA ATC ATG CTA GAG TTT 2264His Ser Gln Ile Asn Ala Asn Glu Ser Glu Glu Ile Met Leu Glu Phe
725 730 735GCC AAG GGA AAT TAT CAG GTT TTA TTA TGC ACT TCT ATT GTG GAA TCA 2312Ala Lys Gly Asn Tyr Gln Val Leu Leu Cys Thr Ser Ile Val Glu Ser
740 745 750GGG ATT CAT TTG CCT AAC GCT AAC ACG ATC ATT ATA GAT AAT GCG CAA 2360Gly Ile His Leu Pro Asn Ala Asn Thr Ile Ile Ile Asp Asn Ala Gln
755 760 765AAT TTC GGG CTG GCT GAT TTG CAC CAA TTG AGA GGG CGT GTG GGG AGA 2408Asn Phe Gly Leu Ala Asp Leu His Gln Leu Arg Gly Arg Val Gly Arg770 775 780 785GGT AAA AAA GAA GGC TTT TGT TAT TTC CTC ATA GAA GAT CAA AAA AGT 2456Gly Lys Lys Glu Gly Phe Cys Tyr Phe Leu Ile Glu Asp Gln Lys Ser
790 795 800TTG AAT GAA CAG GCT TTA AAA CGC TTG CTC GCT TTG GAA AAA AAT TCA 2504Leu Asn Glu Gln Ala Leu Lys Arg Leu Leu Ala Leu Glu Lys Asn Ser
805 810 815TAT TTA GGC AGC GGG GAG AGT GTC GCT TAT CAT GAT TTA GAA ATC AGG 2552Tyr Leu Gly Ser Gly Glu Ser Val Ala Tyr His Asp Leu Glu Ile Arg
820 825 830GGG GGC GGG AAT TTG CTC GGG CAA GAT CAG AGC GGG CAT ATT AAA AAC 2600Gly Gly Gly Asn Leu Leu Gly Gln Asp Gln Ser Gly His Ile Lys Asn
835 840845ATT GGT TAT GCA CTC TAT ACG CGC ATG CTT GAA GAC GCG ATT TAT GAA 2648Ile Gly Tyr Ala Leu Tyr Thr Arg Met Leu Glu Asp Ala Ile Tyr Glu850 855 860 865TTG AGT GGG GGG AAG AAA AGG CTT GAA AAG AGC GTA GAA ATC CAA CTT 2696Leu Ser Gly Gly Lys Lys Arg Leu Glu Lys Ser Val Glu Ile Gln Leu
870 875 880GGC GTG AGC GCT TTT TTA AAC CCT GAA CTC ATT GCA AGC GAT AGT TTG 2744Gly Val Ser Ala Phe Leu Asn Pro Glu Leu Ile Ala Ser Asp Ser Leu
885 890 895AGA TTG GAT TTA TAC CGC CGT TTG AGT TTG TGT GAA AAT ACA GAT GAG 2792Arg Leu Asp Leu Tyr Arg Arg Leu Ser Leu Cys Glu Asn Thr Asp Glu
900 905 910GTG GGG CAA ATC CAT GAA GAA ATA GAA GAC AGG TTT GGC AAA ATA GAC 2840Val Gly Gln Ile His Glu Glu Ile Glu Asp Arg Phe Gly Lys Ile Asp
915 920 925GAT TTG AGC GCT CAA TTT TTG CAA ATC ATT ACG CTT AAA ATT CTA GCC 2888Asp Leu Ser Ala Gln Phe Leu Gln Ile Ile Thr Leu Lys Ile Leu Ala930 935 940 945AAC CAG CTT GGC ATC ATC AAA CTT TCT AAT TTC AAT CAA AAC ATC ACC 2936Asn Gln Leu Gly Ile Ile Lys Leu Ser Asn Phe Asn Gln Asn Ile Thr
950 955 960ATC ACT TAT AGC GAT GAA AAG AAA GAA AGC CTG AAA GCC CCA AGC AAA 2984Ile Thr Tyr Ser Asp Glu Lys Lys Glu Ser Leu Lys Ala Pro Ser Lys
965 970 975GAC GAT AAC GAT ATT TTA GAA ACC CTT TTG AAA CAT TTG CGC GCT CAA 3032Asp Asp Asn Asp Ile Leu Glu Thr Leu Leu Lys His Leu Arg Ala Gln
980 985 990ATT TCT TTA AAG CGG CGT TAAAAGCGTT TGATTTTAGC GTTAATTTTG TTATTTTA 3088Ile Ser Leu Lys Arg Arg
995 1AAAAGATTAT TAA 3101
(2) Sequence 596 data: (i) sequence characteristics: length (A): 999 amino acid (B) types: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 596: met Ile Gln Ser Ser Leu Tyr Arg Ala Leu Asn Lys Gly Phe Asp Tyr 151015 Gln Ile Leu Ala Cys Lys Asp Phe Lys Glu Ser Glu Leu Ala Lys Glu
20 25 30Val Ile Ser Tyr Phe Lys Pro Asn Thr Lys Ala Ile Leu Phe Pro Glu
35 40 45Phe Arg Ala Lys Lys Asn Asp Asp Leu Arg Ser Phe Phe Glu Glu Phe
50 55 60Leu Gln Leu Leu Gly Gly Leu Arg Glu Phe Tyr Gln Ala Leu Glu Asn65 70 75 80Lys Gln Glu Thr Ile Ile Ile Ala Pro Ile Ser Ala Leu Leu His Pro
85 90 95Leu Pro Lys Lys Glu Leu Leu Glu Ser Phe Lys Ile Thr Leu Leu Glu
100 105 110Lys Tyr Asn Leu Lys Asp Leu Lys Asp Lys Leu Phe Tyr Tyr Gly Tyr
115 120 125Glu Ile Leu Asp Leu Val Glu Val Glu Gly Glu Ala Ser Phe Arg Gly
130 135 140Asp Ile Val Asp Ile Tyr Ala Pro Asn Ser Lys Ala Tyr Arg Leu Ser145 150 155 160Phe Phe Asp Thr Glu Cys Glu Ser Ile Lys Glu Phe Asp Pro Ile Thr
165 170 175Gln Met Ser Leu Lys Glu Asp Leu Leu Glu Ile Glu Ile Pro Pro Thr
180 185 190Leu Phe Ser Leu Asp Glu Ser Ser Tyr Lys Asp Leu Lys Thr Lys Val
195 200 205Glu Gln Ser Pro Leu Asn Ser Phe Ser Lys Asp Leu Thr Ser Phe Gly
210 215 220Leu Trp Phe Leu Gly Glu Lys Ala Gln Asp Leu Leu Ile Val Tyr Lys225 230 235 240Ser Ile Ile Ser Pro Arg Ala Leu Glu Glu Ile Gln Glu Leu Ala Ser
245 250 255Leu Asn Glu Leu Asp Cys Glu Arg Phe Lys Phe Leu Lys Val Leu Glu
260 265 270Asn Ala Gln Gly Tyr Glu Asp Leu Glu Ile His Ala His Ala Leu Glu
275 280 285Gly Phe Ile Ala Leu His Ser Asn His Lys Ile Thr Leu Leu Ala Pro
290 295 300Asn Lys Thr Ile Leu Asp Asn Ala Ile Ser Ala Leu Asp Ala Gly Asn305 310 315 320Met Glu Cys Val Ile Ala Pro Phe Val Leu Asn Phe Lys Thr Pro Asp
325 330 335Gly Ile Phe Ile Ser Leu Asn Ser Phe Glu Arg Lys Lys Lys Arg Gln
340 345 350Lys Ser Lys Leu Ala Leu Asn Glu Leu Asn Pro Gly Glu Trp Val Val
355 360 365His Asp Asp Tyr Gly Val Gly Val Phe Ser Gln Leu Val Gln His Ser
370 375 380Val Leu Gly Ser Lys Arg Asp Phe Leu Glu Ile Ala Tyr Leu Gly Glu385 390 395 400Asp Lys Leu Leu Leu Pro Val Glu Asn Leu His Leu Ile Ala Arg Tyr
405 410 415Val Ala Gln Ser Asp Ser Val Pro Ala Lys Asp Arg Leu Gly Lys Gly
420 425 430Ser Phe Leu Lys Leu Lys Ala Lys Val Arg Thr Lys Leu Leu Glu Ile
435 440 445Ala Ser Lys Ile Ile Glu Leu Ala Ala Glu Arg Asn Leu Ile Leu Gly
450 455 460Lys Lys Met Asp Val His Leu Ala Glu Leu Glu Val Phe Lys Ser His465 470 475 480Ala Gly Phe Glu Tyr Thr Ser Asp Gln Glu Lys Ala Ile Ala Glu Ile
485 490 495Ser Lys Asp Leu Ser Ser His Arg Val Met Asp Arg Leu Leu Ser Gly
500 505 510Asp Val Gly Phe Gly Lys Thr Glu Val Ala Met His Ala Ile Phe Cys
515 520 525Ala Phe Leu Asn Gly Phe Gln Ser Ala Leu Val Val Pro Thr Thr Leu
530 535 540Leu Ala His Gln His Phe Glu Thr Leu Arg Ala Arg Phe Glu Asn Phe545 550 555 560Gly Val Lys Val Ala Arg Leu Asp Arg Tyr Ala Ser Glu Lys Asn Lys
565 570 575Leu Leu Lys Ala Val Glu Leu Gly Gln Val Asp Ala Leu Ile Gly Thr
580 585 590His Ala Ile Leu Gly Ala Lys Phe Lys Asn Leu Gly Leu Val Val Val
595 600 605Asp Glu Glu His Lys Phe Gly Val Lys Gln Lys Glu Ala Leu Lys Glu
610 615 620Leu Ser Lys Ser Val His Phe Leu Ser Met Ser Ala Thr Pro Ile Pro625 630 635 640Arg Thr Leu Asn Met Ala Leu Ser Gln Ile Lys Gly Ile Ser Ser Leu
645 650 655Lys Thr Pro Pro Thr Asp Arg Lys Pro Ser Arg Thr Phe Leu Lys Glu
660 665 670Lys Asn Asp Glu Leu Leu Lys Glu Ile Ile Tyr Arg Glu Leu Arg Arg
675 680 685Asn Gly Gln Ile Phe Tyr Ile His Asn His Ile Ala Ser Ile Leu Lys
690 695 700Val Lys Thr Lys Leu Glu Asp Leu Ile Pro Lys Leu Lys Ile Ala Ile705 710 715 720Leu His Ser Gln Ile Asn Ala Asn Glu Ser Glu Glu Ile Met Leu Glu
725 730 735Phe Ala Lys Gly Asn Tyr Gln Val Leu Leu Cys Thr Ser Ile Val Glu
740 745 750Ser Gly Ile His Leu Pro Asn Ala Asn Thr Ile Ile Ile Asp Asn Ala
755 760 765Gln Asn Phe Gly Leu Ala Asp Leu His Gln Leu Arg Gly Arg Val Gly
770 775 780Arg Gly Lys Lys Glu Gly Phe Cys Tyr Phe Leu Ile Glu Asp Gln Lys785 790 795 800Ser Leu Asn Glu Gln Ala Leu Lys Arg Leu Leu Ala Leu Glu Lys Asn
805 810 815Ser Tyr Leu Gly Ser Gly Glu Ser Val Ala Tyr His Asp Leu Glu Ile
820 825 830Arg Gly Gly Gly Asn Leu Leu Gly Gln Asp Gln Ser Gly His Ile Lys
835 840 845Asn Ile Gly Tyr Ala Leu Tyr Thr Arg Met Leu Glu Asp Ala Ile Tyr
850 855 860Glu Leu Ser Gly Gly Lys Lys Arg Leu Glu Lys Ser Val Glu Ile Gln865 870 875 880Leu Gly Val Ser Ala Phe Leu Asn Pro Glu Leu Ile Ala Ser Asp Ser
885 890 895Leu Arg Leu Asp Leu Tyr Arg Arg Leu Ser Leu Cys Glu Asn Thr Asp
900 905 910Glu Val Gly Gln Ile His Glu Glu Ile Glu Asp Arg Phe Gly Lys Ile
915 920 925Asp Asp Leu Ser Ala Gln Phe Leu Gln Ile Ile Thr Leu Lys Ile Leu
930 935 940Ala Asn Gln Leu Gly Ile Ile Lys Leu Ser Asn Phe Asn Gln Asn Ile945 950 955 960Thr Ile Thr Tyr Ser Asp Glu Lys Lys Glu Ser Leu Lys Ala Pro Ser
965 970 975Lys Asp Asp Asn Asp Ile Leu Glu Thr Leu Leu Lys His Leu Arg Ala
980 985 990Gln Ile Ser Leu Lys Arg Arg
995 1
(2) Data in sequence 597: (i) sequence characteristics: length (A): 1217bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1161 (D) other information: (xi) Description of the sequence: sequence 597: AGGCTATGAT ATAGTTTATT TTCACAAAAT CTCCAAGGAA AATTG ATG CAA CAT GAA 57
Met Gln His Glu
1ATC CCT ATT GCC TTT GCC TTT GAT AAA AAC TAC CTA AAA ACA GGG GCT 105Ile Pro Ile Ala Phe Ala Phe Asp Lys Asn Tyr Leu Lys Thr Gly Ala 5 10 15 20GTG GCT CTC TAC TCT TTA TTG CAT GCC CAT CGT GCA GTT GAA GGG GTA 153Val Ala Leu Tyr Ser Leu Leu His Ala His Arg Ala Val Glu Gly Val
25 30 35TTT TTC AGT ATC TAT ATA TTC TAT AGC GGT TTG AAT GAA GAT GAT TTA 201Phe Phe Ser Ile Tyr Ile Phe Tyr Ser Gly Leu Asn Glu Asp Asp Leu
40 45 50AAC AGG CTC CAA GAA ACT ATC AAA CCT TTC AAA CAT TTT GCC GCT TTA 249Asn Arg Leu Gln Glu Thr Ile Lys Pro Phe Lys His Phe Ala Ala Leu
55 60 65AAA TGC CAA GAT ATT AGC GCC ACT CTT GAT TCT TTG CCC ACC ATC ACG 297Lys Cys Gln Asp Ile Ser Ala Thr Leu Asp Ser Leu Pro Thr Ile Thr
70 75 80GAT AGT GCA TGG GTT AAT CGC TAT TCT AGA ATG ATT TTG GTC AAA TAC 345Asp Ser Ala Trp Val Asn Arg Tyr Ser Arg Met Ile Leu Val Lys Tyr85 90 95 100CTT CTC CCT AGT TTA TTC CCC CAA TAC AGC AAA ATG ATT TGG TCT GAT 393Leu Leu Pro Ser Leu Phe Pro Gln Tyr Ser Lys Met Ile Trp Ser Asp
105 110 115GTG GAT GTG GTC TTT TGC AGA GCT TTC GCT GAT GAT TTT ATC GCT TTA 441Val Asp Val Val Phe Cys Arg Ala Phe Ala Asp Asp Phe Ile Ala Leu
120 125 130GAC ACA AGC GAA TCT TTT CAT TTG AGT GGT GTG ATA AGT TTA GTA TCA 489Asp Thr Ser Glu Ser Phe His Leu Ser Gly Val Ile Ser Leu Val Ser
135 140 145CAA TCA GTT ACA GAG GGG TTT TGG TTT TGC AAT TTG GAT TAC ATG CGA 537Gln Ser Val Thr Glu Gly Phe Trp Phe Cys Asn Leu Asp Tyr MetArg
150 155 160AAG CAC TCT TTC ACC CAA CAG GTC TTA GAA AAA TTT AAA ATT CAA GTA 585Lys His Ser Phe Thr Gln Gln Val Leu Glu Lys Phe Lys Ile Gln Val165 170 175 180ATG CGT CCA TAT TTT AAA GAA CCT ACA TTA ATA CAC CAT TTG CAT GCT 633Met Arg Pro Tyr Phe Lys Glu Pro Thr Leu Ile His His Leu His Ala
185 190 195TAT ATT AAA GAA CTT CCC TTA CAC TAT TGC GTT CTG CCT TAT TAT TAT 681Tyr Ile Lys Glu Leu Pro Leu His Tyr Cys Val Leu Pro Tyr Tyr Tyr
200 205 210CAA GAA GAA CTT GAT GAT TTG AGA CAT AAA GCT TCC TTA CCC ATT CGG 729Gln Glu Glu Leu Asp Asp Leu Arg His Lys Ala Ser Leu Pro Ile Arg
215 220 225TTT GAA ATC ATC CAC CAA GAC AAA CCC AAT GAA TTT ATC CAT CGC CAG 777Phe Glu Ile Ile His Gln Asp Lys Pro Asn Glu Phe Ile His Arg Gln
230 235 240CAA ATC CCC TAT GAG ATC TCT CAA ATT CAA AAC ATT CTT TCA AAC CCT 825Gln Ile Pro Tyr Glu Ile Ser Gln Ile Gln Asn Ile Leu Ser Asn Pro245 250 255 260ATT ATC ATG CAC TAT GAA TCT GAT AAA GAT GCT CTT GGA ATC TAC AAT 873Ile Ile Met His Tyr Glu Ser Asp Lys Asp Ala Leu Gly Ile Tyr Asn
265 270 275GGC AAA CCT TGG GAG TTC CCT TTG GGG AAT CAA TAC CAC CTG TGG TTA 921Gly Lys Pro Trp Glu Phe Pro Leu Gly Asn Gln Tyr His Leu Trp Leu
280 285 290GAG ATG CTT GCA CAC ACT CCA TTT TGG AAA GAC TTC ACT CTG GAA ATG 969Glu Met Leu Ala His Thr Pro Phe Trp Lys Asp Phe Thr Leu Glu Met
295 300 305CAA AAA AAA CGCATA GAA TAC CGA GAT ATT GCT CAA AAA ATC CAT TAT 1017Gln Lys Lys Arg Ile Glu Tyr Arg Asp Ile Ala Gln Lys Ile His Tyr
310 315 320TTT TCT CAA GAT AAG CGT CTT TAT GAA GTG AGC ATA CGC TCC ATT AAG 1065Phe Ser Gln Asp Lys Arg Leu Tyr Glu Val Ser Ile Arg Ser Ile Lys325 330 335 340GTT TTT GCA TCT CAT TAC TAT AAT TTA GTG GTT AAA GAA CGA TGG TCT 1113Val Phe Ala Ser His Tyr Tyr Asn Leu Val Val Lys Glu Arg Trp Ser
345 350 355AAA CCA ATA AAA ACT TTC TTT CAA AAA AAT TTT TTT CAA AAA AAG TTC T 1162Lys Pro Ile Lys Thr Phe Phe Gln Lys Asn Phe Phe Gln Lys Lys Phe
360 365 370AATTTGTTGG AATCACAAGG CGAAACCAAA TCCCTAATAC TTATGCTTTC TCAGG 1217
(2) Sequence 598 data: (i) sequence characteristics: length (A): 372 amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 598: met Gln His Glu Ile Pro Ile Ala Phe Ala Phe Asp Lys Asn Tyr Leu 151015 Lys Thr Gly Ala Val Ala Leu Tyr Ser Leu Leu His Ala His Arg Ala
20 25 30Val Glu Gly Val Phe Phe Ser Ile Tyr Ile Phe Tyr Ser Gly Leu Asn
35 40 45Glu Asp Asp Leu Asn Arg Leu Gln Glu Thr Ile Lys Pro Phe Lys His
50 55 60Phe Ala Ala Leu Lys Cys Gln Asp Ile Ser Ala Thr Leu Asp Ser Leu65 70 75 80Pro Thr Ile Thr Asp Ser Ala Trp Val Asn Arg Tyr Ser Arg Met Ile
85 90 95Leu Val Lys Tyr Leu Leu Pro Ser LeuPhe Pro Gln Tyr Ser Lys Met
100 105 110Ile Trp Ser Asp Val Asp Val Val Phe Cys Arg Ala Phe Ala Asp Asp
115 120 125Phe Ile Ala Leu Asp Thr Ser Glu Ser Phe His Leu Ser Gly Val Ile
130 135 140Ser Leu Val Ser Gln Ser Val Thr Glu Gly Phe Trp Phe Cys Asn Leu145 150 155 160Asp Tyr Met Arg Lys His Ser Phe Thr Gln Gln Val Leu Glu Lys Phe
165 170 175Lys Ile Gln Val Met Arg Pro Tyr Phe Lys Glu Pro Thr Leu Ile His
180 185 190His Leu His Ala Tyr Ile Lys Glu Leu Pro Leu His Tyr Cys Val Leu
195 200 205Pro Tyr Tyr Tyr Gln Glu Glu Leu Asp Asp Leu Arg His Lys Ala Ser
210 215 220Leu Pro Ile Arg Phe Glu Ile Ile His Gln Asp Lys Pro Asn Glu Phe225 230 235 240Ile His Arg Gln Gln Ile Pro Tyr Glu Ile Ser Gln Ile Gln Asn Ile
245 250 255Leu Ser Asn Pro Ile Ile Met His Tyr Glu Ser Asp Lys Asp Ala Leu
260 265 270Gly Ile Tyr Asn Gly Lys Pro Trp Glu Phe Pro Leu Gly Asn Gln Tyr
275 280 285His Leu Trp Leu Glu Met Leu Ala His Thr Pro Phe Trp Lys Asp Phe
290 295 300Thr Leu Glu Met Gln Lys Lys Arg Ile Glu Tyr Arg Asp Ile Ala Gln305 310 315 320Lys Ile His Tyr Phe Ser Gln Asp LysArg Leu Tyr Glu Val Ser Ile
325 330 335Arg Ser Ile Lys Val Phe Ala Ser His Tyr Tyr Asn Leu Val Val Lys
340 345 350Glu Arg Trp Ser Lys Pro Ile Lys Thr Phe Phe Gln Lys Asn Phe Phe
355 360 365Gln Lys Lys Phe
370
(2) Sequence 599 data: (i) sequence characteristics: length (A): 780bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 729 (D) other information: (xi) Description of the sequence: sequence 599: TTTAGCTATG ATAAGCGTTT TAAAAACAAA CGAATTTTAA TCAAAATGAG ATTTAAGGGT 60TAAAGAGTGA AAGCGTTTTT AGGAGCGTTA GAGTTTCAAG AGAATGAATA TGAAGAGCTT 120AAAGAGCTTT ATGAGAGCTT AAAAACCAAG CAAAAGCCCC ACACTTTGTT CATTTCTTGT 180GTGGATTCAC GAGTCGTGCC TAATTTAATC ACTGGCACCA AACCGGGCGA ATTGTATGTG 240ATTTGCAAC ATG GGC AAT GTG AAC CCC CCT AAA ACA AGC TAT AAA GAG TCC 291
Met Gly Asn Val Asn Pro Pro Lys Thr Ser Tyr Lys Glu Ser
1 5 10CTT TCT ACC ATT GCG AGC ATT GAA TAC GCT ATC GCG CAT GTG GGC GTT 339Leu Ser Thr Ile Ala Ser Ile Glu Tyr Ala Ile Ala His Val Gly Val15 20 25 30CAA AAC TTA ATC ATT TGC GGG CAT AGC GAT TGT GGG GCT TGC GGG AGC 387Gln Asn Leu Ile Ile Cys Gly His Ser Asp Cys Gly Ala Cys Gly Ser
35 40 45GTT CAT TTA ATC CAT GAT GAA ACC ACC AAA GCT AAA ACC CCT TAC ATT 435Val His Leu Ile His Asp Glu Thr Thr Lys Ala Lys Thr Pro Tyr Ile
50 55 60GCA AAC TGG ATACAA TTT TTA GAG CCT GTT AAA GAA GAG TTA AAA AAC 483Ala Asn Trp Ile Gln Phe Leu Glu Pro Val Lys Glu Glu Leu Lys Asn
65 70 75CAC CCG CAA TTC AGC AAC CAT TTC GCC AAG CGT TCA TGG CTT ACA GAG 531His Pro Gln Phe Ser Asn His Phe Ala Lys Arg Ser Trp Leu Thr Glu
80 85 90CGT TTG AAT GCG CGC TTG CAA CTC AAC AAC CTC TTA AGC TAT GAT TTC 579Arg Leu Asn Ala Arg Leu Gln Leu Asn Asn Leu Leu Ser Tyr Asp Phe95 100 105 110ATT CAA GAG AAA GCG AGC AAG AAT GAA TTA AAA ATT TTT GGT TGG CAC 627Ile Gln Glu Lys Ala Ser Lys Asn Glu Leu Lys Ile Phe Gly Trp His
115 120 125TAC ATC ATA GAA ACA GGC AGG ATT TAT AAT TAT AAT TTT GAA AGC CAT 675Tyr Ile Ile Glu Thr Gly Arg Ile Tyr Asn Tyr Asn Phe Glu Ser His
130 135 140TTT TTT GAG CCG ATT GGA GAA ACC ATT AAA CAA AGG AAA AGT CAT GAA 723Phe Phe Glu Pro Ile Gly Glu Thr Ile Lys Gln Arg Lys Ser His Glu
145 150 155AAC TTC TAAAACAAAA ACCCCTAAAT CCGTTTTAAT CGCTGGGCCA TGCGTCATTG A 780Asn Phe
160
(2) Sequence 600 data: (i) sequence characteristics: length (A): 160 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 600: met Gly Asn Val Asn Pro Pro Lys Thr Ser Tyr Lys Glu Ser Leu Ser 151015 Thr Ile Ala Ser Ile Glu Tyr Ala Ile Ala His Val Gly Val Gln Asn
20 25 30Leu Ile Ile Cys Gly His Ser Asp Cys Gly Ala Cys Gly Ser Val His
3540 45Leu Ile His Asp Glu Thr Thr Lys Ala Lys Thr Pro Tyr Ile Ala Asn
50 55 60Trp Ile Gln Phe Leu Glu Pro Val Lys Glu Glu Leu Lys Asn His Pro65 70 75 80Gln Phe Ser Asn His Phe Ala Lys Arg Ser Trp Leu Thr Glu Arg Leu
85 90 95Asn Ala Arg Leu Gln Leu Asn Asn Leu Leu Ser Tyr Asp Phe Ile Gln
100 105 110Glu Lys Ala Ser Lys Asn Glu Leu Lys Ile Phe Gly Trp His Tyr Ile
115 120 125Ile Glu Thr Gly Arg Ile Tyr Asn Tyr Asn Phe Glu Ser His Phe Phe
130 135 140Glu Pro Ile Gly Glu Thr Ile Lys Gln Arg Lys Ser His Glu Asn Phe145 150 155 160
(2) Sequence 601 data:
(i) sequence characteristics:
(A) length: 450bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 107...385
(D) Other information:
(xi) Description of the sequence: sequence 601: TAAAGATAAA AACCACCCCT TTTGACCCCC TTTTAGAGGA TTTTTATGGT TTTTTTGAGA 60TAATAAAGAC TTATAAAGTT AATTAAAATT AAACAGAAGG GTTTTG ATG TCC GCT 115
Met Ser Ala
1CAT TTT TTA AAA ATC GTT TTT TTA GTA GGC ATG TGC GTT TCA AGT TTG 163His Phe Leu Lys Ile Val Phe Leu Val Gly Met Cys Val Ser Ser Leu
5 10 15TTC GCT GAA GGT TTA GAG GGG TTT TTT AAC GCC CTA GAA GCC CAG CTC 211Phe Ala Glu Gly Leu Glu Gly Phe Phe Asn Ala Leu Glu Ala Gln Leu20 25 30 35AAA AGC CCC ATC GCT AAG GGG ATT TTA ATG GTG ATT TTC ATA GGG ATC 259Lys Ser Pro Ile Ala Lys Gly Ile Leu Met Val Ile Phe Ile Gly Ile
40 45 50GCT ATT TAT GTG TGG AGG AAT TTG GAC CGG TGG AAA GAG ATC TTA TTC 307Ala Ile Tyr Val Trp Arg Asn Leu Asp Arg Trp Lys Glu Ile Leu Phe
55 60 65ACG ATC CTT GGC GTG GTG TTT GGG ATT TTT TTA TTC TTT AAA GCT CCG 355Thr Ile Leu Gly Val Val Phe Gly Ile Phe Leu Phe Phe Lys Ala Pro
70 75 80AGT TTA GCG AAT TGG TTT ATG GGA ATT TTT TAATGATTAT CCTGTCAGCG AGC 408Ser Leu Ala Asn Trp Phe Met Gly Ile Phe
85 90GTGAAGAATT TGCGTGAAAT TTCGGTTAAA GAAAAATTTT TA 450
(2) Sequence 602 data: (i) sequence characteristics: length (A): 93 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 602: met Ser Ala His Phe Leu Lys Ile Val Phe Leu Val Gly Met Cys Val 151015 Ser Ser Leu Phe Ala Glu Gly Leu Glu Gly Phe Phe Asn Ala Leu Glu
20 25 30Ala Gln Leu Lys Ser Pro Ile Ala Lys Gly Ile Leu Met Val Ile Phe
35 40 45Ile Gly Ile Ala Ile Tyr Val Trp Arg Asn Leu Asp Arg Trp Lys Glu
50 55 60Ile Leu Phe Thr Ile Leu Gly Val Val Phe Gly Ile Phe Leu Phe Phe65 70 75 80Lys Ala Pro Ser Leu Ala Asn Trp Phe Met Gly Ile Phe
85 90
(2) Sequence 603 data: (i) sequence characteristics: length (A): 1350bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 77...1291 (D) other information: (xi) Description of the sequence: sequence 603: TGAAGGCCGA TGATTTCATT TCCAAGTCTA ACCCCAAAGA CATCCAGCGA GTGGTTAAGC 60AATTTTTGGA ATTAGC ATG AAA AAA TAC AGC ACT ATC CCC ACC CCT TGC TAC 112
Met Lys Lys Tyr Ser Thr Ile Pro Thr Pro Cys Tyr
1 5 10GTG TTA GAG AGC GAA CGC TTA GAA AAA AAC GCC AAG ATT TTA GAA ATC 160Val Leu Glu Ser Glu Arg Leu Glu Lys Asn Ala Lys Ile Leu Glu Ile
15 20 25GTG CGC CAA CAA AGT GGG GCA AAG GTC TTG CTT GCT TTA AAG GGG TAT 208Val Arg Gln Gln Ser Gly Ala Lys Val Leu Leu Ala Leu Lys Gly Tyr
30 35 40GCG TTT TGG CGT GAG TTT GGG ATT TTG AGG CAA AAA TTG AAC GGG TGT 256Ala Phe Trp Arg Glu Phe Gly Ile Leu Arg Gln Lys Leu Asn Gly Cys45 50 55 60TGC GCG AGC GGT CTT TAT GAG GCT AAG CTC GCT TTT GAA GAA TTT GGG 304Cys Ala Ser Gly Leu Tyr Glu Ala Lys Leu Ala Phe Glu Glu Phe Gly
65 70 75GGG CGA GAG AGC CAC AAA GAA ATT TGC GTT TAT AGC CCG GCT TTC AAA 352Gly Arg Glu Ser His Lys Glu Ile Cys Val Tyr Ser Pro Ala Phe Lys
80 85 90GAG GCT GAA ATG AGC GCG ATT TTA CCC CTA GCG ACA AGC ATT ATT TTT 400Glu Ala Glu Met Ser Ala Ile Leu Pro Leu Ala Thr Ser Ile Ile Phe
95 100 105AAC TCT TTT TAC CAA TAC GCT ACC TAT AAA GAC AGG ATT TTA GAT AAA 448Asn Ser Phe Tyr Gln Tyr Ala Thr Tyr Lys Asp Arg Ile Leu Asp Lys
110 115 120AAC AAG CAA TTA GAA AAC TTG GGC TTA AGC CCC ATT AAA ATG GGT TTG 496Asn Lys Gln Leu Glu Asn Leu Gly Leu Ser Pro Ile Lys Met Gly Leu125 130 135 140AGG ATA AAC CCT CTC TAT AGC GAA GTA ACC CCA GCG ATC TAT AAC CCA 544Arg Ile Asn Pro Leu Tyr Ser Glu Val Thr Pro Ala Ile Tyr Asn Pro
145 150 155TGC TCT AAA GTG AGC CGG TTA GGG ATT ACG CCT AGC GGA TTT GAA AAG 592Cys Ser Lys Val Ser Arg Leu Gly Ile Thr Pro Ser Gly Phe Glu Lys
160 165 170GGG GTG AAA GAG CAT GGC TTA GAG GGG GTG AGC GGG TTG CAT TTC CAT 640Gly Val Lys Glu His Gly Leu Glu Gly Val Ser Gly Leu His Phe His
175 180 185ACG CAT TGC GAG CAA AAC GCT GAC GCT TTG TGC CGG ACT TTA GAG CAT 688Thr His Cys Glu Gln Asn Ala Asp Ala Leu Cys Arg Thr Leu Glu His
190 195 200GTA GAA AAG CAT TTC AGG CCC TAT TTA GAA AAC ATG GCG TGG GTG AAT 736Val Glu Lys His Phe Arg Pro Tyr Leu Glu Asn Met Ala Trp Val Asn205 210 215 220TTT GGT GGG GGG CAT CAT ATC ACT AAG AGC GAT TAT GAT GTG AAT TTG 784Phe Gly Gly Gly His His Ile Thr Lys SerAsp Tyr Asp Val Asn Leu
225 230 235CTC ATC CAA ACG ATT AAG GAT TTC AAA GAA CGC TAT CAT AAT ATA GAA 832Leu Ile Gln Thr Ile Lys Asp Phe Lys Glu Arg Tyr His Asn Ile Glu
240 245 250GTG ATT TTA GAG CCT GGG GAA GCC ATA GGG TGG CAA TGC GGG TTT TTA 880Val Ile Leu Glu Pro Gly Glu Ala Ile Gly Trp Gln Cys Gly Phe Leu
255 260 265ATC GCA AGC GTG ATA GAC ATC GTT CAA AAC GAT CAA GAA ATT GCG ATT 928Ile Ala Ser Val Ile Asp Ile Val Gln Asn Asp Gln Glu Ile Ala Ile
270 275 280CTA GAC GCT TCT TTT AGC GCT CAC ATG CCC GAT TGC TTA GAA ATG CCT 976Leu Asp Ala Ser Phe Ser Ala His Met Pro Asp Cys Leu Glu Met Pro285 290 295 300TAT CGC CCT AGC ATT TTT AAA GTC TCC GTA GAA AAT GAT GAA GAG CTT 1024Tyr Arg Pro Ser Ile Phe Lys Val Ser Val Glu Asn Asp Glu Glu Leu
305 310 315ATT GAA GTT GAA AAG GGC GAA AAT CAA GGG GCG TTT TCT TAT TTT TTA 1072Ile Glu Val Glu Lys Gly Glu Asn Gln Gly Ala Phe Ser Tyr Phe Leu
320 325 330GGC GGC CCT ACT TGT TTA GCG GGG GAT TTT ATG GGG AGT TTT AGC TTT 1120Gly Gly Pro Thr Cys Leu Ala Gly Asp Phe Met Gly Ser Phe Ser Phe
335 340 345GAA ACG CCT TTA AAA AGG GGC GAT AAA ATC GTG TTT CAA GAC ATG CTC 1168Glu Thr Pro Leu Lys Arg Gly Asp Lys Ile Val Phe Gln Asp Met Leu
350 355 360CAT TAT ACG ATT GTC AAA AAC AAC TCG TTT AAT GGC GTG CCG CTC CCA 1216His Tyr Thr Ile Val Lys Asn Asn Ser Phe Asn Gly Val Pro Leu Pro365 370375 380AGC CTG GCT AGA TTG GAT CAA CAA GGG TTT AAA ATC CTT AAA AAC TTT 1264Ser Leu Ala Arg Leu Asp Gln Gln Gly Phe Lys Ile Leu Lys Asn Phe
385 390 395TCT TAT GAA GAC TAT AAA AAC AGA AAC TAAAGCTTTT GATTAAGGCT TTTTGGG 1318Ser Tyr Glu Asp Tyr Lys Asn Arg Asn
400 405GCTTGTAAAA AGNTTACGCA CAACATTCCA AC 1350
(2) Sequence 604 data:
(i) sequence characteristics:
(A) length: 405 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 604: met Lys Lys Tyr Ser Thr Ile Pro Thr Pro Cys Tyr Val Leu Glu Ser 151015 Glu Arg Leu Glu Lys Asn Ala Lys Ile Leu Glu Ile Val Arg Gln Gln
20 25 30Ser Gly Ala Lys Val Leu Leu Ala Leu Lys Gly Tyr Ala Phe Trp Arg
35 40 45Glu Phe Gly Ile Leu Arg Gln Lys Leu Asn Gly Cys Cys Ala Ser Gly
50 55 60Leu Tyr Glu Ala Lys Leu Ala Phe Glu Glu Phe Gly Gly Arg Glu Ser65 70 75 80His Lys Glu Ile Cys Val Tyr Ser Pro Ala Phe Lys Glu Ala Glu Met
85 90 95Ser Ala Ile Leu Pro Leu Ala Thr Ser Ile Ile Phe Asn Ser Phe Tyr
100105 110Gln Tyr Ala Thr Tyr Lys Asp Arg Ile Leu Asp Lys Asn Lys Gln Leu
115 120 125Glu Asn Leu Gly Leu Ser Pro Ile Lys Met Gly Leu Arg Ile Asn Pro
130 135 140Leu Tyr Ser Glu Val Thr Pro Ala Ile Tyr Asn Pro Cys Ser Lys Val145 150 155 160Ser Arg Leu Gly Ile Thr Pro Ser Gly Phe Glu Lys Gly Val Lys Glu
165 170 175His Gly Leu Glu Gly Val Ser Gly Leu His Phe His Thr His Cys Glu
180 185 190Gln Asn Ala Asp Ala Leu Cys Arg Thr Leu Glu His Val Glu Lys His
195 200 205Phe Arg Pro Tyr Leu Glu Asn Met Ala Trp Val Asn Phe Gly Gly Gly
210 215 220His His Ile Thr Lys Ser Asp Tyr Asp Val Asn Leu Leu Ile Gln Thr225 230 235 240Ile Lys Asp Phe Lys Glu Arg Tyr His Asn Ile Glu Val Ile Leu Glu
245 250 255Pro Gly Glu Ala Ile Gly Trp Gln Cys Gly Phe Leu Ile Ala Ser Val
260 265 270Ile Asp Ile Val Gln Asn Asp Gln Glu Ile Ala Ile Leu Asp Ala Ser
275 280 285Phe Ser Ala His Met Pro Asp Cys Leu Glu Met Pro Tyr Arg Pro Ser
290 295 300Ile Phe Lys Val Ser Val Glu Asn Asp Glu Glu Leu Ile Glu Val Glu305 310 315 320Lys Gly Glu Asn Gln Gly Ala Phe Ser Tyr Phe Leu Gly Gly Pro Thr
325 330335Cys Leu Ala Gly Asp Phe Met Gly Ser Phe Ser Phe Glu Thr Pro Leu
340 345 350Lys Arg Gly Asp Lys Ile Val Phe Gln Asp Met Leu His Tyr Thr Ile
355 360 365Val Lys Asn Asn Ser Phe Asn Gly Val Pro Leu Pro Ser Leu Ala Arg
370 375 380Leu Asp Gln Gln Gly Phe Lys Ile Leu Lys Asn Phe Ser Tyr Glu Asp385 390 395 400Tyr Lys Asn Arg Asn
405
(2) Sequence 605 data:
(i) sequence characteristics:
(A) length: 609bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 246...548
(D) Other information:
(xi) Description of the sequence: sequence 605: GAATCTTTAC TTTATAATTT GCCTGACCTT TTAAAAGAAC ACTCTAATGA AAATGTCTTG 60CTCATCTTAC ACTTGCAGGC TCGCATGGCC CAAACTACGA CAACAAAGTG CCTTTAAATT 120TTAGGGTGTT TAAGCCTTAT TGCTCAAGCG CTGATCTGTC TTCTTGCTCC AAAGAAAGCC 180TGATTAACGC CTATGACAAC ACCATTTTTT ACAACGACTA TCTGCTAGAT CGAAAGATCA 240TTAGC ATG CTT GAA AAC GCC AAG CAG CCC GCC TTA ATG ATC TAT TTA AGC 290 Met Leu Glu Asn Ala Lys Gln Pro Ala Leu Met Ile Tyr Leu Ser;
1 5 10 15GTA CAT GGC GAA AGT TTG GGC GAA GAA GCG TTC TAT TTG CAT GGC ATT338Asp His Gly Glu Ser Leu Gly Glu Glu Ala Phe Tyr Leu His Gly Ile
20 25 30CCT AAA AGC ATC GCC CCC AAA GAA CAA TAC GAG ATC CCC TTT ATC GTT 386Pro Lys Ser Ile Ala Pro Lys Glu Gln Tyr Glu Ile Pro Phe Ile Val
35 40 45TAT GCT AAT GAG CCT TTC AAA GAA AAG CAT TCC ATC ATT CAA ACC CAA 434Tyr Ala Asn Glu Pro Phe Lys Glu Lys His Ser Ile Ile Gln Thr Gln 50 55 60ACC CCC ATT AAT CAA AAT GTG ATT TTC CAT AGC GTT TTA GGG GTG TTT 482Thr Pro Ile Asn Gln Asn Val Ile Phe His Ser Val Leu Gly Val Phe
65 70 75TTG GAT TTT AAA AAC CCA AGC GTT GTT TAT CGC CCT TCT TTA GAT CTG 530Leu Asp Phe Lys Asn Pro Ser Val Val Tyr Arg Pro Ser Leu Asp Leu80 85 90 95CTT AAA CAC AAA AAA GAG TAAAATAACA CGCATGAAAA AATTCTTATT TAAACAAA 586Leu Lys His Lys Lys Glu
100AATTTTGTGA AAGCCTGCCC AAA 609
(2) sequence 606 data: (i) sequence characteristics: length (A): 101 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 606: met Leu Glu Asn Ala Lys Gln Pro Ala Leu Met Ile Tyr Leu Ser Asp 151015 His Gly Glu Ser Leu Gly Glu Glu Ala Phe Tyr Leu His Gly Ile Pro
20 25 30Lys Ser Ile Ala Pro Lys Glu Gln Tyr Glu Ile Pro Phe Ile Val Tyr
35 40 45Ala Asn Glu Pro Phe Lys Glu Lys His Ser Ile Ile Gln Thr Gln Thr
50 55 60Pro Ile Asn Gln Asn Val Ile Phe His Ser Val Leu Gly Val Phe Leu65 70 75 80Asp Phe Lys Asn Pro Ser Val Val Tyr Arg Pro Ser Leu Asp Leu Leu
85 90 95Lys His Lys Lys Glu
100(2) sequence 607 data: (i) sequence characteristics: length (A): 872bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 123 … 818 (D) other information: (xi) Description of the sequence: sequence 607: AGTTTTAGCG ATAATTATAT CTTTTATGGC AATAAAACGA GCGTTTGTAA GCAAATCGGT 60AACGCTGTGC CTCCTCTTCT AGCCCTAGCC TTAGGCAAAG CGATCTTAAA AAGCTTAAGA 120AA ATG ATA CAA ATT TAT CAC GCT GAC GCT TTT GAA ATC ATC AAA GAC 167Met Ile Gln Ile Tyr His Ala Asp Ala Phe Glu Ile Ile Lys Asp
1 5 10 15TTT TAC CAG CAA AAT TTA AAA GTG GAT GCG ATC ATC ACG GAC CCT CCT 215Phe Tyr Gln Gln Asn Leu Lys Val Asp Ala Ile Ile Thr Asp Pro Pro
20 25 30TAT AAC ATT TCG GTT AAA AAC AAT TTT CCC ACC CTA AAG AGC GCT AAA 263Tyr Asn Ile Ser Val Lys Asn Asn Phe Pro Thr Leu Lys Ser Ala Lys
35 40 45AGG CAA GGC ATA GAT TTT GGG GAA TGG GAT AAA AAT TTC AAG CTT TTA 311Arg Gln Gly Ile Asp Phe Gly Glu Trp Asp Lys Asn Phe Lys Leu Leu
50 55 60GAA TGG ATC GCA CGC TAC GCC CCC TTA GTC AAT CCA AAC GGC TGC ATG 359Glu Trp Ile Ala Arg Tyr Ala Pro Leu Val Asn Pro Asn Gly Cys Met
65 70 75GTT ATT TTT TGC TCT TAC AGG TTT ATA AGC TAT ATC GCT GAT TTT TTA 407Val Ile Phe Cys Ser Tyr Arg Phe Ile Ser Tyr Ile Ala Asp Phe Leu8085 90 95GAA GAA AAC GGC TTT GTG GTC AAA GAC TTT ATC CAA TGG GTT AAA AAT 455Glu Glu Asn Gly Phe Val Val Lys Asp Phe Ile Gln Trp Val Lys Asn
100 105 110AAT CCC ATG CCA AGA AAC ATT CAC CGG CGT TAT GTC CAA GAC ACG GAA 503Asn Pro Met Pro Arg Asn Ile His Arg Arg Tyr Val Gln Asp Thr Glu
115 120 125TTT GCT CTG TGG GCG GTT AAA AAG AAA GCC AAG TGG GTG TTT AAC AAA 551Phe Ala Leu Trp Ala Val Lys Lys Lys Ala Lys Trp Val Phe Asn Lys
130 135 140CCC AAA AAT GAA AAA TAT TTA CGG CCT TTG ATT TTA AAA AGC CCT GTG 599Pro Lys Asn Glu Lys Tyr Leu Arg Pro Leu Ile Leu Lys Ser Pro Val
145 150 155GTA AGC GGG CTT GAA AAA ACC AAA CAC CCC ACG CAA AAA AGC CTG GCC 647Val Ser Gly Leu Glu Lys Thr Lys His Pro Thr Gln Lys Ser Leu Ala160 165 170 175TTA ATG GAA AAA ATC ATT TCC ATC CAC ACA AAC CCT AAT GAC ATC GTG 695Leu Met Glu Lys Ile Ile Ser Ile His Thr Asn Pro Asn Asp Ile Val
180 185 190CTA GAT CCT TTC ATG GGG AGC GGC ACC ACC GGC TTA GCG TGC AAA AAT 743Leu Asp Pro Phe Met Gly Ser Gly Thr Thr Gly Leu Ala Cys Lys Asn
195 200 205TTA GAA CGG AAT TTT ATC GGC ATA GAA TCA GAA AAA GAA TAT TTT CAA 791Leu Glu Arg Asn Phe Ile Gly Ile Glu Ser Glu Lys Glu Tyr Phe Gln
210 215 220ACC GCT AAA AAG CGT TTG AAT CTG TTT TAAAAACGCT ATTTGAATGA GATTGTG 845Thr Ala Lys Lys Arg Leu Asn Leu Phe
225 230TTATAGTTAT TTAAAAGGAT ATTTTGA872
(2) Sequence 608 data: (i) sequence characteristics: length (A): 232 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 608: met Ile Gln Ile Tyr His Ala Asp Ala Phe Glu Ile Ile Lys Asp Phe 151015 Tyr Gln Gln Asn Leu Lys Val Asp Ala Ile Ile Thr Asp Pro Pro Tyr
20 25 30Asn Ile Ser Val Lys Asn Asn Phe Pro Thr Leu Lys Ser Ala Lys Arg
35 40 45Gln Gly Ile Asp Phe Gly Glu Trp Asp Lys Asn Phe Lys Leu Leu Glu
50 55 60Trp Ile Ala Arg Tyr Ala Pro Leu Val Asn Pro Asn Gly Cys Met Val65 70 75 80Ile Phe Cys Ser Tyr Arg Phe Ile Ser Tyr Ile Ala Asp Phe Leu Glu
85 90 95Glu Asn Gly Phe Val Val Lys Asp Phe Ile Gln Trp Val Lys Asn Asn
100 105 110Pro Met Pro Arg Asn Ile His Arg Arg Tyr Val Gln Asp Thr Glu Phe
115 120 125Ala Leu Trp Ala Val Lys Lys Lys Ala Lys Trp Val Phe Asn Lys Pro
130 135 140Lys Asn Glu Lys Tyr Leu Arg Pro Leu Ile Leu Lys Ser Pro Val Val145 150 155 160Ser Gly Leu Glu Lys Thr Lys His Pro Thr Gln Lys Ser Leu Ala Leu
165 170 175Met Glu Lys Ile Ile Ser Ile His Thr Asn Pro Asn Asp Ile Val Leu
180 185 190Asp Pro Phe Met Gly Ser Gly Thr Thr Gly Leu Ala Cys Lys Asn Leu
195 200 205Glu Arg Asn Phe Ile Gly Ile Glu Ser Glu Lys Glu Tyr Phe Gln Thr
210 215 220Ala Lys Lys Arg Leu Asn Leu Phe225 230
(2) Sequence 609 data: (i) sequence characteristics: length (A): 1181bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1124 (D) other information: (xi) Description of the sequence: sequence 609: TTGCGTTTTG AAACCGATGA TTTTTCAACG CTTATTGATC GTATTTGTGA AAGCTTGAA 59ATG AAT TAT AAA ATT TTA GAT TTA TTT TGT GGG GCT GGG GGT TTT AGC 107Met Asn Tyr Lys Ile Leu Asp Leu Phe Cys Gly Ala Gly Gly Phe Ser 151015 GCT GGG TTA GAG TGT TTA GAA GAG TTT GAC GCT TTA ATA GGG CTA GAT 155Ala Gly Leu Glu Cys Leu Glu Glu Phe Asp Ala Leu Ile Gly Leu Asp
20 25 30TGC GAT AAA CAA GCC CTA ATC ACT TTT GAA AAC AAC CAT AAA AAC GCC 203Cys Asp Lys Gln Ala Leu Ile Thr Phe Glu Asn Asn His Lys Asn Ala
35 40 45ATA GGC GTT TGT GGG GAC ATC ACT CAA ACC GAA ATT AAA GAA AAA GTC 251Ile Gly Val Cys Gly Asp Ile Thr Gln Thr Glu Ile Lys Glu Lys Val
50 55 60ATC AAA CTA GCT AAA AAA TTA GAA ATC AAC ATG ATC ATT GGC GGG CCT 299Ile Lys Leu Ala Lys Lys Leu Glu Ile Asn Met Ile Ile Gly Gly Pro 65 70 75 80CCA TGT CAA GGC TTT TCT AAT AAA GGG AAA AAT TTA GGG CTA AAA GAC 347Pro Cys Gln Gly Phe Ser Asn Lys Gly Lys Asn Leu Gly Leu Lys Asp
85 90 95CCT AGG AAT TTT TTA TTC TTA GAA TAT ATA GAA ATA GTC AAA GCC ATA 395Pro Arg Asn Phe Leu Phe Leu Glu Tyr Ile Glu Ile Val Lys Ala Ile
100 105 110AAG CCA GAA ATT TTT ATC ATT GAA AAC GTG AAA AAC CTC ATC TCT TGC 443Lys Pro Glu Ile Phe Ile Ile Glu Asn Val Lys Asn Leu Ile Ser Cys
115 120 125GCT AAA GGC TAT TTT TTA GAA GAA ATT AAA GAA AGG TTG AAC GCT TTA 491Ala Lys Gly Tyr Phe Leu Glu Glu Ile Lys Glu Arg Leu Asn Ala Leu
130 135 140GGG TAT CAA TTG AGC TAT CAA ATC CTA AAC GCT AAA GAT TAT GGC GTG 539Gly Tyr Gln Leu Ser Tyr Gln Ile Leu Asn Ala Lys Asp Tyr Gly Val145 150 155 160CCT CAA AAC AGA GAG AGA GCC TTT ATT GTA GGG GCT AGT CGT TTC AGT 587Pro Gln Asn Arg Glu Arg Ala Phe Ile Val Gly Ala Ser Arg Phe Ser
165 170 175TTT GAT TTC AAT CTT TTA GAG CCT TCT CAA AGC GTG AAT GTT CAA GAT 635Phe Asp Phe Asn Leu Leu Glu Pro Ser Gln Ser Val Asn Val Gln Asp
180 185 190GCC ATA AGC GAT TTA GCC TAT CTT TGT TCT AAT GAG GGG GCG TTT GAG 683Ala Ile Ser Asp Leu Ala Tyr Leu Cys Ser Asn Glu Gly Ala Phe Glu
195 200 205AGC GAT TAT TTA AAC CCT ATC CAA TCA AGC TAT CAA GCT TTA ATG CGA 731Ser Asp Tyr Leu Asn Pro Ile Gln Ser Ser Tyr Gln Ala Leu Met Arg
210 215 220AAA GAT AGC CCT AAA TTA TAC AAC CAT CAA GCC ACC AAC CAC TCG CAA 779Lys Asp Ser Pro Lys Leu Tyr Asn His Gln Ala Thr Asn His Ser Gln225 230 235 240GCC GCT TTA GAG AAA TTA AAA CTC ATT AAC AAA GAA CAA GGC AAA GAA 827Ala Ala Leu Glu Lys Leu Lys Leu Ile Asn Lys Glu Gln Gly Lys Glu
245 250 255TGC TTG CCT AAA AAC TTG CAT GGC AAA CAG CAA TTC AAA AGC ACA TGG 875Cys Leu Pro Lys Asn Leu His Gly Lys Gln Gln Phe Lys Ser Thr Trp
260 265 270GGG CGC CTG AAT TGG AAT AAA ATC AGC CCC ACC ATA GAC ACA CGA TTT 923Gly Arg Leu Asn Trp Asn Lys Ile Ser Pro Thr Ile Asp Thr Arg Phe
275 280 285GAC ACT CCC AGC AAT GGC ACC AAC TCC CAC CCC GAA TTG CAC CGC TCT 971Asp Thr Pro Ser Asn Gly Thr Asn Ser His Pro Glu Leu His Arg Ser
290 295 300ATC ACG CCT AGA GAA GCC GCT AGG ATA CAA AGT TTT AGC GAT AAT TAT 1019Ile Thr Pro Arg Glu Ala Ala Arg Ile Gln Ser Phe Ser Asp Asn Tyr305 310 315 320ATC TTT TAT GGC AAT AAA ACG AGC GTT TGT AAG CAA ATC GGT AAC GCT 1067Ile Phe Tyr Gly Asn Lys Thr Ser Val Cys Lys Gln Ile Gly Asn Ala
325 330 335GTG CCT CCT CTT CTA GCC CTA GCC TTA GGC AAA GCG ATC TTA AAA AGC 1115Val Pro Pro Leu Leu Ala Leu Ala Leu Gly Lys Ala Ile Leu Lys Ser
340 345 350TTA AGA AAA TGATACAAAT TTATCACGCT GACGCTTTTG AAATCATCAA AGACTTTTAC 1174Leu Arg Lys
355CAGCAAA 1181
(2) Sequence 610 data: (i) sequence characteristics: length (A): 355 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 610: met Asn Tyr Lys Ile Leu Asp Leu Phe Cys Gly Ala Gly Gly Phe Ser 151015 Ala Gly Leu Glu Cys Leu Glu Glu Phe Asp Ala Leu Ile Gly Leu Asp
2025 30Cys Asp Lys Gln Ala Leu Ile Thr Phe Glu Asn Asn His Lys Asn Ala
35 40 45Ile Gly Val Cys Gly Asp Ile Thr Gln Thr Glu Ile Lys Glu Lys Val
50 55 60Ile Lys Leu Ala Lys Lys Leu Glu Ile Asn Met Ile Ile Gly Gly Pro65 70 75 80Pro Cys Gln Gly Phe Ser Asn Lys Gly Lys Asn Leu Gly Leu Lys Asp
85 90 95Pro Arg Asn Phe Leu Phe Leu Glu Tyr Ile Glu Ile Val Lys Ala Ile
100 105 110Lys Pro Glu Ile Phe Ile Ile Glu Asn Val Lys Asn Leu Ile Ser Cys
115 120 125Ala Lys Gly Tyr Phe Leu Glu Glu Ile Lys Glu Arg Leu Asn Ala Leu
130 135 140Gly Tyr Gln Leu Ser Tyr Gln Ile Leu Asn Ala Lys Asp Tyr Gly Val145 150 155 160Pro Gln Asn Arg Glu Arg Ala Phe Ile Val Gly Ala Ser Arg Phe Ser
165 170 175Phe Asp Phe Asn Leu Leu Glu Pro Ser Gln Ser Val Asn Val Gln Asp
180 185 190Ala Ile Ser Asp Leu Ala Tyr Leu Cys Ser Asn Glu Gly Ala Phe Glu
195 200 205Ser Asp Tyr Leu Asn Pro Ile Gln Ser Ser Tyr Gln Ala Leu Met Arg
210 215 220Lys Asp Ser Pro Lys Leu Tyr Asn His Gln Ala Thr Asn His Ser Gln225 230 235 240Ala Ala Leu Glu Lys Leu Lys Leu Ile Asn Lys Glu Gln Gly Lys Glu
245250 255Cys Leu Pro Lys Asn Leu His Gly Lys Gln Gln Phe Lys Ser Thr Trp
260 265 270Gly Arg Leu Asn Trp Asn Lys Ile Ser Pro Thr Ile Asp Thr Arg Phe
275 280 285Asp Thr Pro Ser Asn Gly Thr Asn Ser His Pro Glu Leu His Arg Ser
290 295 300Ile Thr Pro Arg Glu Ala Ala Arg Ile Gln Ser Phe Ser Asp Asn Tyr305 310 315 320Ile Phe Tyr Gly Asn Lys Thr Ser Val Cys Lys Gln Ile Gly Asn Ala
325 330 335Val Pro Pro Leu Leu Ala Leu Ala Leu Gly Lys Ala Ile Leu Lys Ser
340 345 350Leu Arg Lys
355
(2) Sequence 611 data: (i) sequence characteristics: length (A): 1361bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1305 (D) other information: (xi) Description of the sequence: sequence 611: TATTGATAGC ATGAGTTGTT TTTGGTTTGG AATTTTAAGG AGTAGCTT ATG AAA GAG 57
Met Lys GluCAA TCA ATG ATT GAT TTT TTA AAA CTT AGA GAT TAT GAC ATT AGA AAA 105Gln Ser Met Ile Asp Phe Leu Lys Leu Arg Asp Tyr Asp Ile Arg Lys
5 10 15ACA CAA AAT GCG CGA TGG ATA GAT CAA AAA TGC ACC CCT GAT GTG TTG 153Thr Gln Asn Ala Arg Trp Ile Asp Gln Lys Cys Thr Pro Asp Val Leu20 25 30 35TCT CTT GTT GCT GAT TGT ATT TTA GAG TTT ACG CAA TGT AAT ATT GGA 201Ser Leu Val Ala Asp Cys Ile Leu Glu Phe ThrGln Cys Asn Ile Gly
40 45 50AAA TCA TTT TCT ATT AGG GAT ATT TGG GAT AGC CCT TAC ACC AAT GAA 249Lys Ser Phe Ser Ile Arg Asp Ile Trp Asp Ser Pro Tyr Thr Asn Glu
55 60 65AAT GTT AAA ATG ATT TTT TCT AAA CCT GAT TTA AAT TCT GAC TTT TCC 297Asn Val Lys Met Ile Phe Ser Lys Pro Asp Leu Asn Ser Asp Phe Ser
70 75 80ATG CAT GAA TAC GAT AAG TTT TTT TCT CAG CCT ATT AAA TTA TTA GCC 345Met His Glu Tyr Asp Lys Phe Phe Ser Gln Pro Ile Lys Leu Leu Ala
85 90 95TAT AGC GGT ATT TTA TTT GAA ACA AAA ACT GGC AAT AGA AAT ATT TAT 393Tyr Ser Gly Ile Leu Phe Glu Thr Lys Thr Gly Asn Arg Asn Ile Tyr100 105 110 115ACC ATA CAA AAC ATA GAG CTA TTA GAA TAT CTC ATG CAA AGA GAA ACA 441Thr Ile Gln Asn Ile Glu Leu Leu Glu Tyr Leu Met Gln Arg Glu Thr
120 125 130AAC GCT TTG AAA TTC CTT ATT TTA TAT ATT CAA AAG GTA TTA ATG GAT 489Asn Ala Leu Lys Phe Leu Ile Leu Tyr Ile Gln Lys Val Leu Met Asp
135 140 145AGT GGG ATT TAT CCT TTA TTT GAC AAC TTT TTA CAA AAA CAA GAC ACA 537Ser Gly Ile Tyr Pro Leu Phe Asp Asn Phe Leu Gln Lys Gln Asp Thr
150 155 160GAA AGT TTT AAG CAA CTA AAA GAT GGT TTC ACT CAT TTT ACT ATC AAT 585Glu Ser Phe Lys Gln Leu Lys Asp Gly Phe Thr His Phe Thr Ile Asn
165 170 175AAC ACA GCA ATC AAT AAC GCT ACG GAA TGT TTT AGG ATT TTT ACT AAA 633Asn Thr Ala Ile Asn Asn Ala Thr Glu Cys Phe Arg Ile Phe Thr Lys180 185 190 195ATT ATC AAT CCT TTA GCT TTT TAT TAT GGT AAA AAA GGC ACA AGA AAA 681Ile Ile Asn Pro Leu Ala Phe Tyr Tyr Gly Lys Lys Gly Thr Arg Lys
200 205 210GGG TAT TTG TCC AAC ACT ATA ATT ACA AAA GAT GAG CTT AAT TAT AAT 729Gly Tyr Leu Ser Asn Thr Ile Ile Thr Lys Asp Glu Leu Asn Tyr Asn
215 220 225CGT ATC AAT TGG CGA GAT ATA GGA AAA GAT AAA AAT ACC ACC AGA CAA 777Arg Ile Asn Trp Arg Asp Ile Gly Lys Asp Lys Asn Thr Thr Arg Gln
230 235 240GAA TAC GAT CTT ATA AAC TCT AAA AGG ATT GCT AAT TCT AAC TAT CTT 825Glu Tyr Asp Leu Ile Asn Ser Lys Arg Ile Ala Asn Ser Asn Tyr Leu
245 250 255ATT TCA AAA GCT AAG AAA GTG GTG AAA CGA TAT AAT GAT AGA TTT AAT 873Ile Ser Lys Ala Lys Lys Val Val Lys Arg Tyr Asn Asp Arg Phe Asn260 265 270 275AAT TCT CTC TCT GAA GTA AAA CAA GAA AAA GAA GAG TCG CAA GCC ACA 921Asn Ser Leu Ser Glu Val Lys Gln Glu Lys Glu Glu Ser Gln Ala Thr
280 285 290CAA ATA CAC CAT ATT TTT CCC ATC CAA GAC TTT CCC ATT ATT GCT AAC 969Gln Ile His His Ile Phe Pro Ile Gln Asp Phe Pro Ile Ile Ala Asn
295 300 305TAT ATA GAG AAT CTT ATC GCA CTC ACT CCT AAT CAA CAT TTT ATT TAC 1017Tyr Ile Glu Asn Leu Ile Ala Leu Thr Pro Asn Gln His Phe Ile Tyr
310 315 320GCC CAC CCT AAT AAT CAA ACC CGC TTG ATT GAT AAA GAT TTT CAA TAT 1065Ala His Pro Asn Asn Gln Thr Arg Leu Ile Asp Lys Asp Phe Gln Tyr
325 330 335ATC TGC TTA TTA GCT AAA ACG ACC ACAATT CTT AAT GAC ACT CAA GGC 1113Ile Cys Leu Leu Ala Lys Thr Thr Thr Ile Leu Asn Asp Thr Gln Gly340 345 350 355GTA TAT GAT TGG AAT GAT TAT ATT GTT GTG TTG AAT ATG GGC CTC AAA 1161Val Tyr Asp Trp Asn Asp Tyr Ile Val Val Leu Asn Met Gly Leu Lys
360 365 370ACA ACT ATC TTT TCT CAA GTC AAG AAC GAA TGG GAA TTA TTA AAA GTA 1209Thr Thr Ile Phe Ser Gln Val Lys Asn Glu Trp Glu Leu Leu Lys Val
375 380 385ATA GAT GCT TTT TAT TTT GAT TTT AAC AAG AGC AAA GAT CCA AGT TGG 1257Ile Asp Ala Phe Tyr Phe Asp Phe Asn Lys Ser Lys Asp Pro Ser Trp
390 395 400TCA TAC TTG CTA GAT AAA AAC GAT TTA AGA GCT TTC AAG CTA AAA TTT T 1306Ser Tyr Leu Leu Asp Lys Asn Asp Leu Arg Ala Phe Lys Leu Lys Phe
405 410 415AATAAGTTTT ATTGAAACTG GGTATAAAAA CCCGCTTGAC TTATCTTATC CTTTT 1361
(2) Sequence 612 data: (i) sequence characteristics: length (A): 419 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 612: met Lys Glu Gln Ser Met Ile Asp Phe Leu Lys Leu Arg Asp Tyr Asp 151015 Ile Arg Lys Thr Gln Asn Ala Arg Trp Ile Asp Gln Lys Cys Thr Pro
20 25 30Asp Val Leu Ser Leu Val Ala Asp Cys Ile Leu Glu Phe Thr Gln Cys
35 40 45Asn Ile Gly Lys Ser Phe Ser Ile Arg Asp Ile Trp Asp Ser Pro Tyr
50 55 60Thr Asn Glu Asn Val Lys Met Ile Phe Ser Lys Pro Asp Leu Asn Ser65 70 7580Asp Phe Ser Met His Glu Tyr Asp Lys Phe Phe Ser Gln Pro Ile Lys
85 90 95Leu Leu Ala Tyr Ser Gly Ile Leu Phe Glu Thr Lys Thr Gly Asn Arg
100 105 110Asn Ile Tyr Thr Ile Gln Asn Ile Glu Leu Leu Glu Tyr Leu Met Gln
115 120 125Arg Glu Thr Asn Ala Leu Lys Phe Leu Ile Leu Tyr Ile Gln Lys Val
130 135 140Leu Met Asp Ser Gly Ile Tyr Pro Leu Phe Asp Asn Phe Leu Gln Lys145 150 155 160Gln Asp Thr Glu Ser Phe Lys Gln Leu Lys Asp Gly Phe Thr His Phe
165 170 175Thr Ile Asn Asn Thr Ala Ile Asn Asn Ala Thr Glu Cys Phe Arg Ile
180 185 190Phe Thr Lys Ile Ile Asn Pro Leu Ala Phe Tyr Tyr Gly Lys Lys Gly
195 200 205Thr Arg Lys Gly Tyr Leu Ser Asn Thr Ile Ile Thr Lys Asp Glu Leu
210 215 220Asn Tyr Asn Arg Ile Asn Trp Arg Asp Ile Gly Lys Asp Lys Asn Thr225 230 235 240Thr Arg Gln Glu Tyr Asp Leu Ile Asn Ser Lys Arg Ile Ala Asn Ser
245 250 255Asn Tyr Leu Ile Ser Lys Ala Lys Lys Val Val Lys Arg Tyr Asn Asp
260 265 270Arg Phe Asn Asn Ser Leu Ser Glu Val Lys Gln Glu Lys Glu Glu Ser
275 280 285Gln Ala Thr Gln Ile His His Ile Phe Pro Ile Gln Asp Phe Pro Ile
290 295300Ile Ala Asn Tyr Ile Glu Asn Leu Ile Ala Leu Thr Pro Asn Gln His305 310 315 320Phe Ile Tyr Ala His Pro Asn Asn Gln Thr Arg Leu Ile Asp Lys Asp
325 330 335Phe Gln Tyr Ile Cys Leu Leu Ala Lys Thr Thr Thr Ile Leu Asn Asp
340 345 350Thr Gln Gly Val Tyr Asp Trp Asn Asp Tyr Ile Val Val Leu Asn Met
355 360 365Gly Leu Lys Thr Thr Ile Phe Ser Gln Val Lys Asn Glu Trp Glu Leu
370 375 380Leu Lys Val Ile Asp Ala Phe Tyr Phe Asp Phe Asn Lys Ser Lys Asp385 390 395 400Pro Ser Trp Ser Tyr Leu Leu Asp Lys Asn Asp Leu Arg Ala Phe Lys
405 410 415Leu Lys Phe
(2) Sequence 613 data: (i) sequence characteristics: length (A): 2610bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 90...2558 (D) other information: (xi) Description of the sequence: sequence 613: TAAAGAGGCT TTTGAAACCA TGCTTAAAGA AATTGAGAGC TTGAAACATT AATGCTTCAA 60ATGAATTTGG TTTAATCCTT AATCCCCTT ATG CTC TTT GAT CAA ACC TTA ACC 113
Met Leu Phe Asp Gln Thr Leu Thr
1 5TAT ATT TCT TTA TTT TCT GGG GCA GGA GTG GGG TGC TAT GGG CTT TTA 161Tyr Ile Ser Leu Phe Ser Gly Ala Gly Val Gly Cys Tyr Gly Leu Leu
10 15 20GAA GAG GGG TTT GAA TGC GTT GCT ACC AAT GAA ATT TTA GAA AAA CGC 209Glu Glu Gly Phe Glu Cys Val Ala Thr Asn Glu Ile Leu Glu Lys Arg25 30 35 40TTG AAT ATC CAA AGG ATT AAT CGC AAA TGC AAA TTA GAT GAA AGC TAC 257Leu Asn Ile Gln Arg Ile Asn Arg Lys Cys Lys Leu Asp Glu Ser Tyr
45 50 55ATT AGT GGG GAC ATT AAA AAG CCA GAA ACA AAA GAA AAA ATT TTA AAG 305Ile Ser Gly Asp Ile Lys Lys Pro Glu Thr Lys Glu Lys Ile Leu Lys
60 65 70CAA ATT GAA TTT TAT TCT AAA AAA TTT GGT AAT GAT AGG GTT GAT TTA 353Gln Ile Glu Phe Tyr Ser Lys Lys Phe Gly Asn Asp Arg Val Asp Leu
75 80 85GTG GTA GCA ACC CCA CCT TGT CAA GGC ATG AGC GTA GCC AAT CAT AAG 401Val Val Ala Thr Pro Pro Cys Gln Gly Met Ser Val Ala Asn His Lys
90 95 100AAG AAA AAC GAT GAG ATC AAA CGG AAT TCT TTG GTG GTT GAA AGC ATT 449Lys Lys Asn Asp Glu Ile Lys Arg Asn Ser Leu Val Val Glu Ser Ile105 110 115 120GAT TTG ATC AAA CAA ATC AAA CCC AGA TTT TTT ATT TTA GAA AAT GTC 497Asp Leu Ile Lys Gln Ile Lys Pro Arg Phe Phe Ile Leu Glu Asn Val
125 130 135CCT AGT TTT TAT AAA ACA GGT TGT ATA GAC AAA AAT GAT AAT TTG CTA 545Pro Ser Phe Tyr Lys Thr Gly Cys Ile Asp Lys Asn Asp Asn Leu Leu
140 145 150GAA ATA GGA TCT ATG ATA GAG CAA AAT TTG AGT GGC GAT TAT ATG CTC 593Glu Ile Gly Ser Met Ile Glu Gln Asn Leu Ser Gly Asp Tyr Met Leu
155 160 165TAT GAT GAG GTA ATC AAT TTT AAA AAT TTT GGA GCT AAT TCA AGC CGA 641Tyr Asp Glu Val Ile Asn Phe Lys Asn Phe Gly Ala Asn Ser Ser Arg
170 175 180ACA AGA ACT TTA GTG ATA GGG GTT TGT AAA GAG TTT AAA GAT TTT ATA 689Thr Arg Thr Leu Val Ile Gly Val Cys Lys Glu Phe Lys Asp Phe Ile185 190 195 200AGC GCG TTA GAA TTT TTT CCT GAT TTC AAA CAA GAA AAA ACC TTA AAA 737Ser Ala Leu Glu Phe Phe Pro Asp Phe Lys Gln Glu Lys Thr Leu Lys
205 210 215GAA GTG ATA GGA TCG TTA AAA CCA CTT GCT TGG GGC GAG TAT GAC AAC 785Glu Val Ile Gly Ser Leu Lys Pro Leu Ala Trp Gly Glu Tyr Asp Asn
220 225 230ACG GAT TTT TAT CAT AGT TTT AGA ACT TAT CCA AAG CAT ATG CAA GAA 833Thr Asp Phe Tyr His Ser Phe Arg Thr Tyr Pro Lys His Met Gln Glu
235 240 245TGG ATT AAG GAT TTA AAA GAA GGA CAA AGC GCG TTT GAG AAT ACA GAA 881Trp Ile Lys Asp Leu Lys Glu Gly Gln Ser Ala Phe Glu Asn Thr Glu
250 255 260TTA AAC AAA AAA CCT CAT AGA ATT GTT GGC AGT AAG ATT GTC TTA AAT 929Leu Asn Lys Lys Pro His Arg Ile Val Gly Ser Lys Ile Val Leu Asn265 270 275 280GTT TCT AAA AAT GGC GAT AAA TAT AAA AGA CAA AAA TAT CAT AGC GTT 977Val Ser Lys Asn Gly Asp Lys Tyr Lys Arg Gln Lys Tyr His Ser Val
285 290 295GCC CCT TGC ATT CAT ACA AGA AAC GAC CAA ATG GCT AGC CAA AAC ACG 1025Ala Pro Cys Ile His Thr Arg Asn Asp Gln Met Ala Ser Gln Asn Thr
300 305 310ATC CAC CCC AAA GAT GAT AGA GTG TTT TCC ATT AGA GAG CTG ATG CTT 1073Ile His Pro Lys Asp Asp Arg Val Phe Ser Ile Arg Glu Leu Met Leu
315 320 325TTA ATG AATATC CCT AGC CGT TTT AAG TGG TTA GAT TTA GAA TTA CAA 1121Leu Met Asn Ile Pro Ser Arg Phe Lys Trp Leu Asp Leu Glu Leu Gln
330 335 340GAA TTA AAC GCC CTT AAC CAA CAA GAA AAA GAA AAA ATC TCC AAA CAA 1169Glu Leu Asn Ala Leu Asn Gln Gln Glu Lys Glu Lys Ile Ser Lys Gln345 350 355 360AAC GAA ATG AAT ATA AGA CAA AGC ATC GGT GAA GCT GTT CCA ACG ATT 1217Asn Glu Met Asn Ile Arg Gln Ser Ile Gly Glu Ala Val Pro Thr Ile
365 370 375ATT TTT AAG CAA ATT GCC ATA AAG ATA AAA AAT TTC ATG TCT CAA ACC 1265Ile Phe Lys Gln Ile Ala Ile Lys Ile Lys Asn Phe Met Ser Gln Thr
380 385 390CAC TTA GAG CCT AAA GAA ATC ATT AGG CTT ATT GAT GTG CAC CAT TTA 1313His Leu Glu Pro Lys Glu Ile Ile Arg Leu Ile Asp Val His His Leu
395 400 405TTA GAG CCA CAA AAT TTG AAG CGA TTT ATT TTA GAA AAT CAA AAC AAG 1361Leu Glu Pro Gln Asn Leu Lys Arg Phe Ile Leu Glu Asn Gln Asn Lys
410 415 420ATT GCA AGA GCG AGT TTA GTG AGT TTG GCA GAA ATG TCT AAT TCT AAA 1409Ile Ala Arg Ala Ser Leu Val Ser Leu Ala Glu Met Ser Asn Ser Lys425 430 435 440CGC ATA GAA AAA AGC GCG TAT TTT ACA AAC CCT TTT ATT ATT AAT GAA 1457Arg Ile Glu Lys Ser Ala Tyr Phe Thr Asn Pro Phe Ile Ile Asn Glu
445 450 455ATA GCG AAG TTA TTG CCA AGC TTT AAA CAA GAG AGT GTT ACT ATT ATA 1505Ile Ala Lys Leu Leu Pro Ser Phe Lys Gln Glu Ser Val Thr Ile Ile
460 465 470GAG CCA AGT GCA GGG TGT GGG AAT TTC TTA AGT GCT CTT TTT AAA AAA 1553Glu Pro SerAla Gly Cys Gly Asn Phe Leu Ser Ala Leu Phe Lys Lys
475 480 485TAC ACT TCT GTT AAA AAA GTT TAT TTA AAG TGT ATA GAT ATT GAT AAA 1601Tyr Thr Ser Val Lys Lys Val Tyr Leu Lys Cys Ile Asp Ile Asp Lys
490 495 500AAT AGT TTA GAA ATT TTA GAG ATT TTA TAT AAA GAT TGC ATT CCT AAC 1649Asn Ser Leu Glu Ile Leu Glu Ile Leu Tyr Lys Asp Cys Ile Pro Asn505 510 515 520AAT TTT GAG ATG GAA TTG ATT TGC AAA GAT TTT CTA GCC TAT GAA TGC 1697Asn Phe Glu Met Glu Leu Ile Cys Lys Asp Phe Leu Ala Tyr Glu Cys
525 530 535GGC AAA GTG GAT TTA ATT GTG GGC AAT CCG CCT TTT GGC AAA ACG CAT 1745Gly Lys Val Asp Leu Ile Val Gly Asn Pro Pro Phe Gly Lys Thr His
540 545 550GAA AGA TTC AAA GAT TAT AGT TTA AGA CTC ACT CAT TTA GCA GGG ATT 1793Glu Arg Phe Lys Asp Tyr Ser Leu Arg Leu Thr His Leu Ala Gly Ile
555 560 565TTT TTA GAA AAG TCT TTA AAA CTA GCC AAC TTT ACA GCG ATG GTT ATG 1841Phe Leu Glu Lys Ser Leu Lys Leu Ala Asn Phe Thr Ala Met Val Met
570 575 580CCT AAA AAC CTT TTA AAC ACT AAA GAG TAT GCA GAA ACT AGA ACT AAG 1889Pro Lys Asn Leu Leu Asn Thr Lys Glu Tyr Ala Glu Thr Arg Thr Lys585 590 595 600CTT GAA AAA AAG GGA GTA GGA GCG ATT TTA GAC TTT GGC GAG CTT GGT 1937Leu Glu Lys Lys Gly Val Gly Ala Ile Leu Asp Phe Gly Glu Leu Gly
605 610 615TTT AAG GGT GTT TTG GTA GAA ACA ATT GCT ATT GTT ACA CAA AAA TCA 1985Phe Lys Gly Val Leu Val Glu Thr Ile Ala Ile Val Thr Gln Lys Ser
620 625 630AAA GAA GTT TTA GCG CGT TCG TTA CCC CTA AAT CTA AGC ATC AAG CAA 2033Lys Glu Val Leu Ala Arg Ser Leu Pro Leu Asn Leu Ser Ile Lys Gln
635 640 645AAG CCA AGC TAT ATT TTT GAC AAA CAA TTG CCC TAT TGG GTT ATC TAT 2081Lys Pro Ser Tyr Ile Phe Asp Lys Gln Leu Pro Tyr Trp Val Ile Tyr
650 655 660CGC AAC GCT TTT TTT GAT AAG GTG TTT CAT TCC ATG CAG TTT GGT CTT 2129Arg Asn Ala Phe Phe Asp Lys ValPhe His Ser Met Gln Phe Gly Leu665 670 675 680TTT GAA GTG TTT AGA GAC AGA CAA ATC ACT AAT TCT GTG TTG GTT AAA 2177Phe Glu Val Phe Arg Asp Arg Gln Ile Thr Asn Ser Val Leu Val Lys
685 690 695AAT GGT ATT CGT GTG ATT AAA TCT CGC AAT ATT GAT GAA AAC GGA AAG 2225Asn Gly Ile Arg Val Ile Lys Ser Arg Asn Ile Asp Glu Asn Gly Lys
700 705 710ATT ATT AGC ATT GAA AAT TAC GAT AGC TAC ATT CAA AAA GAG GTT TTA 2273Ile Ile Ser Ile Glu Asn Tyr Asp Ser Tyr Ile Gln Lys Glu Val Leu
715 720 725AGT CCG TTT AAG ATA GCT TCA TTT TTA GAC AGA GAT GAT GTC TAT TTA 2321Ser Pro Phe Lys Ile Ala Ser Phe Leu Asp Arg Asp Asp Val Tyr Leu
730 735 740ACC CCC AAC ATG ACC TAT AAG CCA AGG ATT TTA AAA AAA GAA AAA GGC 2369Thr Pro Asn Met Thr Tyr Lys Pro Arg Ile Leu Lys Lys Glu Lys Gly745 750 755 760TAT GTG GTT AAT GGC TCT GTG GCT ATT TTA ATC CCT AAA AAC CCC ATA 2417Tyr Val Val Asn Gly Ser Val Ala Ile Leu Ile Pro Lys Asn Pro Ile
765 770 775TCT TTA AGCAAG AAA CAA TGC GAT TAT ATC TCT AGC GTT GAA TTT AGA 2465Ser Leu Ser Lys Lys Gln Cys Asp Tyr Ile Ser Ser Val Glu Phe Arg
780 785 790GAT TTT TAT AAA ATC GCT AGG AAT TAT CAA ACG CGC ACC TTA AAT ATT 2513Asp Phe Tyr Lys Ile Ala Arg Asn Tyr Gln Thr Arg Thr Leu Asn Ile
795 800 805GAT AGC ATG AGT TGT TTT TGG TTT GGA ATT TTA AGG AGT AGC TTA TGAAA 2563Asp Ser Met Ser Cys Phe Trp Phe Gly Ile Leu Arg Ser Ser Leu
810 815 820GAGCAATCAA TGATTGATTT TTTAAAACTT AGAGATTATG ACATTAG 2610
(2) Sequence 614 data: (i) sequence characteristics: length (A): 823 amino acid (B) types: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 614: met Leu Phe Asp Gln Thr Leu Thr Tyr Ile Ser Leu Phe Ser Gly Ala 151015 Gly Val Gly Cys Tyr Gly Leu Leu Glu Glu Gly Phe Glu Cys Val Ala
20 25 30Thr Asn Glu Ile Leu Glu Lys Arg Leu Asn Ile Gln Arg Ile Asn Arg
35 40 45Lys Cys Lys Leu Asp Glu Ser Tyr Ile Ser Gly Asp Ile Lys Lys Pro
50 55 60Glu Thr Lys Glu Lys Ile Leu Lys Gln Ile Glu Phe Tyr Ser Lys Lys65 70 75 80Phe Gly Asn Asp Arg Val Asp Leu Val Val Ala Thr Pro Pro Cys Gln
85 90 95Gly Met Ser Val Ala Asn His Lys Lys Lys Asn Asp Glu Ile Lys Arg
100 105 110Asn Ser Leu Val Val Glu Ser Ile Asp Leu Ile Lys Gln Ile Lys Pro
115 120 125Arg Phe Phe Ile Leu Glu Asn Val Pro Ser Phe Tyr Lys Thr Gly Cys
130 135 140Ile Asp Lys Asn Asp Asn Leu Leu Glu Ile Gly Ser Met Ile Glu Gln145 150 155 160Asn Leu Ser Gly Asp Tyr Met Leu Tyr Asp Glu Val Ile Asn Phe Lys
165 170 175Asn Phe Gly Ala Asn Ser Ser Arg Thr Arg Thr Leu Val Ile Gly Val
180 185 190Cys Lys Glu Phe Lys Asp Phe Ile Ser Ala Leu Glu Phe Phe Pro Asp
195 200 205Phe Lys Gln Glu Lys Thr Leu Lys Glu Val Ile Gly Ser Leu Lys Pro
210 215 220Leu Ala Trp Gly Glu Tyr Asp Asn Thr Asp Phe Tyr His Ser Phe Arg225 230 235 240Thr Tyr Pro Lys His Met Gln Glu Trp Ile Lys Asp Leu Lys Glu Gly
245 250 255Gln Ser Ala Phe Glu Asn Thr Glu Leu Asn Lys Lys Pro His Arg Ile
260 265 270Val Gly Ser Lys Ile Val Leu Asn Val Ser Lys Asn Gly Asp Lys Tyr
275 280 285Lys Arg Gln Lys Tyr His Ser Val Ala Pro Cys Ile His Thr Arg Asn
290 295 300Asp Gln Met Ala Ser Gln Asn Thr Ile His Pro Lys Asp Asp Arg Val305 310 315 320Phe Ser Ile Arg Glu Leu Met Leu Leu Met Asn Ile Pro Ser Arg Phe
325 330 335Lys Trp Leu Asp Leu Glu Leu Gln Glu Leu Asn Ala Leu Asn Gln Gln
340 345 350Glu Lys Glu Lys Ile Ser Lys Gln Asn Glu Met Asn Ile Arg Gln Ser
355 360 365Ile Gly Glu Ala Val Pro Thr Ile Ile Phe Lys Gln Ile Ala Ile Lys
370 375 380Ile Lys Asn Phe Met Ser Gln Thr His Leu Glu Pro Lys Glu Ile Ile385 390 395 400Arg Leu Ile Asp Val His His Leu Leu Glu Pro Gln Asn Leu Lys Arg
405 410 415Phe Ile Leu Glu Asn Gln Asn Lys Ile Ala Arg Ala Ser Leu Val Ser
420 425 430Leu Ala Glu Met Ser Asn Ser Lys Arg Ile Glu Lys Ser Ala Tyr Phe
435 440 445Thr Asn Pro Phe Ile Ile Asn Glu Ile Ala Lys Leu Leu Pro Ser Phe
450 455 460Lys Gln Glu Ser Val Thr Ile Ile Glu Pro Ser Ala Gly Cys Gly Asn465 470 475 480Phe Leu Ser Ala Leu Phe Lys Lys Tyr Thr Ser Val Lys Lys Val Tyr
485 490 495Leu Lys Cys Ile Asp Ile Asp Lys Asn Ser Leu Glu Ile Leu Glu Ile
500 505 510Leu Tyr Lys Asp Cys Ile Pro Asn Asn Phe Glu Met Glu Leu Ile Cys
515 520 525Lys Asp Phe Leu Ala Tyr Glu Cys Gly Lys Val Asp Leu Ile Val Gly
530 535 540Asn Pro Pro Phe Gly Lys Thr His Glu Arg Phe Lys Asp Tyr Ser Leu545 550 555 560Arg Leu Thr His Leu Ala Gly Ile Phe Leu Glu Lys Ser Leu Lys Leu
565 570 575Ala Asn Phe Thr Ala Met Val Met Pro Lys Asn Leu Leu Asn Thr Lys
580 585 590Glu Tyr Ala Glu Thr Arg Thr Lys Leu Glu Lys Lys Gly Val Gly Ala
595 600 605Ile Leu Asp Phe Gly Glu Leu Gly Phe Lys Gly Val Leu Val Glu Thr
610 615 620Ile Ala Ile Val Thr Gln Lys Ser Lys Glu Val Leu Ala Arg Ser Leu625 630 635 640Pro Leu Asn Leu Ser Ile Lys Gln Lys Pro Ser Tyr Ile Phe Asp Lys
645 650 655Gln Leu Pro Tyr Trp Val Ile Tyr Arg Asn Ala Phe Phe Asp Lys Val
660 665 670Phe His Ser Met Gln Phe Gly Leu Phe Glu Val Phe Arg Asp Arg Gln
675 680 685Ile Thr Asn Ser Val Leu Val Lys Asn Gly Ile Arg Val Ile Lys Ser
690 695 700Arg Asn Ile Asp Glu Asn Gly Lys Ile Ile Ser Ile Glu Asn Tyr Asp705 710 715 720Ser Tyr Ile Gln Lys Glu Val Leu Ser Pro Phe Lys Ile Ala Ser Phe
725 730 735Leu Asp Arg Asp Asp Val Tyr Leu Thr Pro Asn Met Thr Tyr Lys Pro
740 745 750Arg Ile Leu Lys Lys Glu Lys Gly Tyr Val Val Asn Gly Ser Val Ala
755 760 765Ile Leu Ile Pro Lys Asn Pro Ile Ser Leu Ser Lys Lys Gln Cys Asp
770 775 780Tyr Ile Ser Ser Val Glu Phe Arg Asp Phe Tyr Lys IleAla Arg Asn785 790 795 800Tyr Gln Thr Arg Thr Leu Asn Ile Asp Ser Met Ser Cys Phe Trp Phe
805 810 815Gly Ile Leu Arg Ser Ser Leu
820
(2) Data of sequence 615:
(i) sequence characteristics:
(A) length: 3666bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 54...3608
(D) Other information:
(xi) Description of the sequence: sequence 615: CCCGCTTAAA ACATGCTACA ATCAAGTCAA ATTCTTAAAT AAAAGGTAAG CTC ATG 56
Met
1CAA AAA ATC ATT GAC GAT TCG CTA GAA TTA GCT AAA AAA CTG CAA GAT 104Gln Lys Ile Ile Asp Asp Ser Leu Glu Leu Ala Lys Lys Leu Gln Asp
5 10 15AGT ATC AGT AAC CAT TTG AGC GAT CAG GAA AAA GCG TTC CAC TCT AAA 152Ser Ile Ser Asn His Leu Ser Asp Gln Glu Lys Ala Phe His Ser Lys
20 25 30ATG CAA AAG CTT TTA AAC AAC CCT GAA AAC AAA GTC ATG CTC ATA GAG 200Met Gln Lys Leu Leu Asn Asn Pro Glu Asn Lys Val Met Leu Ile Glu
35 40 45CTTATG GAT CGG AGT TTC AGG TGC TTG GAC AAT AAA GCC CGC TTT GAA 248Leu Met Asp Arg Ser Phe Arg Cys Leu Asp Asn Lys Ala Arg Phe Glu50 55 60 65ATG ATT GAG CAT GTT TTA GAC AAA TAC AAA AGC CGT GAG ATT TTT TCT 296Met Ile Glu His Val Leu Asp Lys Tyr Lys Ser Arg Glu Ile Phe Ser
70 75 80CCG TTT GAA AAA GTG CTT TTA ATG GGG TTT TTA AGC TTT GGG AAA ATG 344Pro Phe Glu Lys Val Leu Leu Met Gly Phe Leu Ser Phe Gly Lys Met
85 90 95CTC CCT GAT ATG AGC GTG CCT TTC TTT GTC AAT AAA ATC AGA AGC GAC 392Leu Pro Asp Met Ser Val Pro Phe Phe Val Asn Lys Ile Arg Ser Asp
100 105 110ACG AAA GCG ATG GTC TTG GAT CAA GAA GAG AGC CAG TTA AAA GAG CGG 440Thr Lys Ala Met Val Leu Asp Gln Glu Glu Ser Gln Leu Lys Glu Arg
115 120 125ATT TTA AAA AGA AAA AAT GAA AAA ATC ATT TTG AAT GTG AAT TTT ATT 488Ile Leu Lys Arg Lys Asn Glu Lys Ile Ile Leu Asn Val Asn Phe Ile130 135 140 145GGC GAA GAG GTT TTA GGC GAA GAA GAA GCT AAT GCG CGT TTT GAA AAA 536Gly Glu Glu Val Leu Gly Glu Glu Glu Ala Asn Ala Arg Phe Glu Lys
150 155 160TAC TCT CAA GCC CTA AAA TCC AAC TAC ATC CAA TAC ATT TCC ATT AAA 584Tyr Ser Gln Ala Leu Lys Ser Asn Tyr Ile Gln Tyr Ile Ser Ile Lys
165 170 175ATC ACG ACG ATT TTT TCT CAA ATC AAT ATC CTT GAT TTT GAA TAC TCT 632Ile Thr Thr Ile Phe Ser Gln Ile Asn Ile Leu Asp Phe Glu Tyr Ser
180 185 190AAA AAA GAG ATT GTC AAA CGC CTA GAC GCT CTT TAC GCC CTG GCT TTA 680Lys Lys Glu Ile Val Lys Arg Leu Asp Ala Leu Tyr Ala Leu Ala Leu
195 200 205GAA GAA GAA AAA AAA CAA GGC ATG CCT AAA TTC ATC AAT TTG GAT ATG 728Glu Glu Glu Lys Lys Gln Gly Met Pro Lys Phe Ile Asn Leu Asp Met210 215 220 225GAA GAA TTT AGG GAT TTA GAG CTA ACA GTG GAG TCG TTT ATG GAA TCC 776Glu Glu Phe Arg Asp Leu Glu Leu Thr Val Glu Ser Phe Met Glu Ser
230 235 240ATC GCT AAA TTT GAT TTG AAC GCT GGT ATT GTG CTG CAA GCC TAT ATT 824Ile Ala Lys Phe Asp Leu Asn Ala Gly Ile Val Leu Gln Ala Tyr Ile
245 250 255CCG GAT TCT TAT GAA TAT TTG AAA AAA CTG CAC GCT TTT TCT AAA GAA 872Pro Asp Ser Tyr Glu Tyr Leu Lys Lys Leu His Ala Phe Ser Lys Glu
260 265 270AGG GTT TTA AAA GGG TTG AAG CCC ATT AAA ATC CGC TTT GTT AAG GGA 920Arg Val Leu Lys Gly Leu Lys Pro Ile Lys Ile Arg Phe Val Lys Gly
275 280 285GCG AAC ATG GAG AGC GAA GAA ACT ATC GCT TCC GTG AAA GAT TGG GCG 968Ala Asn Met Glu Ser Glu Glu Thr Ile Ala Ser Val Lys Asp Trp Ala290 295 300 305TTA CCC ACA TTT TCC AAT AAG CAA GAC ACC GAT TCT AAT TAC AAT AAA 1016Leu Pro Thr Phe Ser Asn Lys Gln Asp Thr Asp Ser Asn Tyr Asn Lys
310 315 320ATG TTG GAT TTT GTT TTA GAG GGC GAT AAT TAT AAA TAC ATT CAT ATT 1064Met Leu Asp Phe Val Leu Glu Gly Asp Asn Tyr Lys Tyr Ile His Ile
325 330 335GGC GCA GCG AGT CAT AAT ATT TTT GAA ATC GCT TAT GTC TAT ACG CGT 1112Gly Ala Ala Ser His Asn Ile Phe Glu Ile Ala Tyr Val Tyr Thr Arg
340345 350ATC CAT GCC ATT AAT GAT CCT GTT GTG TTA GAG CAT TTC AGC TTT GAA 1160Ile His Ala Ile Asn Asp Pro Val Val Leu Glu His Phe Ser Phe Glu
355 360 365ATG CTA GAG GGC ATG AGT TTG CAA GCG AGC CAG GAA CTA AAA GAG ATG 1208Met Leu Glu Gly Met Ser Leu Gln Ala Ser Gln Glu Leu Lys Glu Met370 375 380 385CAC AAG CTC ATT CTT TAT GCG CCG GTG TGC GAT GAA GCG CAT TTT AAC 1256His Lys Leu Ile Leu Tyr Ala Pro Val Cys Asp Glu Ala His Phe Asn
390 395 400AAT GCG ATC GCT TAC TTG GTG AGG AGG TTA GAC GAA AAC ACC TCA AGC 1304Asn Ala Ile Ala Tyr Leu Val Arg Arg Leu Asp Glu Asn Thr Ser Ser
405 410 415GAT AAT TTC ATG AAG GCT TTC TTT AAC CTC AAA GTA GGC ACG AGC GAA 1352Asp Asn Phe Met Lys Ala Phe Phe Asn Leu Lys Val Gly Thr Ser Glu
420 425 430TGG AAA GAT CAA GAA CAA CGC TTT TTA AAC AGC CTT AAA GGA ATT GCC 1400Trp Lys Asp Gln Glu Gln Arg Phe Leu Asn Ser Leu Lys Gly Ile Ala
435 440 445ACT TTA GAC AAT GCC ACC CAT AGG ACT CAA GAT AGG AAC GCC AAA CAA 1448Thr Leu Asp Asn Ala Thr His Arg Thr Gln Asp Arg Asn Ala Lys Gln450 455 460 465AGC GGG CAT ACC ACT TAC CCA AAC CAC TCC TTT AAA AAC GAA AGC GAT 1496Ser Gly His Thr Thr Tyr Pro Asn His Ser Phe Lys Asn Glu Ser Asp
470 475 480ACC GAT TTT ATT TTA AAA GCC AAC CGA GAA TGG GCT AAA AAA GTG CGC 1544Thr Asp Phe Ile Leu Lys Ala Asn Arg Glu Trp Ala Lys Lys Val Arg
485 490 495GAG AAA ATG CGT AAC GCT CCT ATT TTA GAGCTT TAC CCA GAG ATG GAT 1592Glu Lys Met Arg Asn Ala Pro Ile Leu Glu Leu Tyr Pro Glu Met Asp
500 505 510GGG AGG TTT GAA GAT CCT AAT CTA ACC CCT TTA GAA GTC TTT GAT AGA 1640Gly Arg Phe Glu Asp Pro Asn Leu Thr Pro Leu Glu Val Phe Asp Arg
515 520 525ATC CAT CAT AAA AAA ATC GCT AGC GTG CAT TTA GCG GAT AAG GAA GCG 1688Ile His His Lys Lys Ile Ala Ser Val His Leu Ala Asp Lys Glu Ala530 535 540 545ATT TTA AAA GCC CTA GAA GTG GCT AAA AGC GAT AAG AGC CGT TTC AGT 1736Ile Leu Lys Ala Leu Glu Val Ala Lys Ser Asp Lys Ser Arg Phe Ser
550 555 560CAA AAA AGC TTT ACA GAA ATC CAT GCC TTA ATG AGT CAA ACC GCC CAG 1784Gln Lys Ser Phe Thr Glu Ile His Ala Leu Met Ser Gln Thr Ala Gln
565 570 575CTT TTT AGA GAA AGA AGA GGC GAT TTG ATA GGG ATT TCC GCT TTA GAA 1832Leu Phe Arg Glu Arg Arg Gly Asp Leu Ile Gly Ile Ser Ala Leu Glu
580 585 590GTG GGT AAG ACT TTC GCT GAA ACG GAC GCT GAA GTG AGC GAA GCC ATT 1880Val Gly Lys Thr Phe Ala Glu Thr Asp Ala Glu Val Ser Glu Ala Ile
595 600 605GAC TTT TTA GAG TTT TAC CCT TAC AGC TTA AGG GTG TTG CAA GAG CAA 1928Asp Phe Leu Glu Phe Tyr Pro Tyr Ser Leu Arg Val Leu Gln Glu Gln610 615 620 625AAC ACA AAA ACG CAA TTC ACC CCT AAA GGC GTG GGC GTG GTC ATT GCC 1976Asn Thr Lys Thr Gln Phe Thr Pro Lys Gly Val Gly Val Val Ile Ala
630 635 640CCA TGG AAT TTC CCT GTG GGC ATT TCT GTA GGC ACT ATC GCT GCC CCC 2024Pro Trp Asn Phe Pro Val Gly Ile Ser Val GlyThr Ile Ala Ala Pro
645 650 655CTA GCT ACG GGC AAT CGG GTG ATT TAC AAG CCC TCA AGT TTG TCT AGC 2072Leu Ala Thr Gly Asn Arg Val Ile Tyr Lys Pro Ser Ser Leu Ser Ser
660 665 670GTA ACG GGC TAT AAG CTT TGT GAG TGC TTT TGG GAT GCG GGC GTG CCT 2120Val Thr Gly Tyr Lys Leu Cys Glu Cys Phe Trp Asp Ala Gly Val Pro
675 680 685AGA GAT GCG CTC ATT TAC TTG CCC TCT AAA GGG AGC GAT ATT AGC GAA 2168Arg Asp Ala Leu Ile Tyr Leu Pro Ser Lys Gly Ser Asp Ile Ser Glu690 695 700 705CAT CTT TTA AGA GAT GAA AGC ATC CAG TTT GCC ATT TTA ACC GGG GGC 2216His Leu Leu Arg Asp Glu Ser Ile Gln Phe Ala Ile Leu Thr Gly Gly
710 715 720GAA GAC ACC GCT TAT AAA ATG TTA AAA GCT AAC CCC ACT TTA GCC TTG 2264Glu Asp Thr Ala Tyr Lys Met Leu Lys Ala Asn Pro Thr Leu Ala Leu
725 730 735AGC GCT GAA ACA GGC GGT AAA AAC GCC ACC ATT GTG AGC AAA ATG GCA 2312Ser Ala Glu Thr Gly Gly Lys Asn Ala Thr Ile Val Ser Lys Met Ala
740 745 750GAC AGA GAC CAG GCG ATT AAG AAT GTT ATC CAT TCA GCT TTT AGC AAT 2360Asp Arg Asp Gln Ala Ile Lys Asn Val Ile His Ser Ala Phe Ser Asn
755 760 765TCG GGG CAA AAA TGC TCC GCC ACT TCG CTT TTA GTA TTA GAA AAA GAA 2408Ser Gly Gln Lys Cys Ser Ala Thr Ser Leu Leu Val Leu Glu Lys Glu770 775 780 785GTC TAT GAA GAT GAG AAC TTT AAA AAG ACT CTA ATA GAT GCG ACT CTA 2456Val Tyr Glu Asp Glu Asn Phe Lys Lys Thr Leu Ile Asp Ala Thr Leu
790795 800AGC CTT AGC GTG GGC GAT CCT TTT GAT TTC AAA AAC AAA ATC GGC GCT 2504Ser Leu Ser Val Gly Asp Pro Phe Asp Phe Lys Asn Lys Ile Gly Ala
805 810 815CTA GCG GAC AAG CCT AAT GAA AAG GTC ATC AAA GCC ATA GAT GAA TTA 2552Leu Ala Asp Lys Pro Asn Glu Lys Val Ile Lys Ala Ile Asp Glu Leu
820 825 830AAA AGC TAT GAA AAT TAC GAA ATC CCG GTA AGC TTT GTC AAT GAT AAC 2600Lys Ser Tyr Glu Asn Tyr Glu Ile Pro Val Ser Phe Val Asn Asp Asn
835 840 845CCC TAT TTG ATG AAG CCA AGC ATC AAA TAC GGC ACT AAA AAA GGC GAT 2648Pro Tyr Leu Met Lys Pro Ser Ile Lys Tyr Gly Thr Lys Lys Gly Asp850 855 860 865TTC ACG CAC CAA ACT GAG CTT TTT ACG CCC ATT TTA TCC GTG ATG GAA 2696Phe Thr His Gln Thr Glu Leu Phe Thr Pro Ile Leu Ser Val Met Glu
870 875 880GCA AAA GAT TTA GAC GAA GCG ATA GAA ATA GCC AAT TCT ACC GGT TAC 2744Ala Lys Asp Leu Asp Glu Ala Ile Glu Ile Ala Asn Ser Thr Gly Tyr
885 890 895GGG CTG ACT AGC GCG TTA GAG TCG TTG GAC GAA AGG GAG TGG GAA TAT 2792Gly Leu Thr Ser Ala Leu Glu Ser Leu Asp Glu Arg Glu Trp Glu Tyr
900 905 910TAT TTA GAA CGC ATT GAA GCC GGT AAT ATC TAT ATC AAC AAG CCC ACC 2840Tyr Leu Glu Arg Ile Glu Ala Gly Asn Ile Tyr Ile Asn Lys Pro Thr
915 920 925ACA GGA GCG ATT GTC TTG CGC CAG CCT TTT GGG GGG GTT AAA AAA TCC 2888Thr Gly Ala Ile Val Leu Arg Gln Pro Phe Gly Gly Val Lys Lys Ser930 935 940 945GCT GTG GGG TTT GGG AGG AAA GTA GGC ATT TTC AACTAT ATC ACG CAA 2936Ala Val Gly Phe Gly Arg Lys Val Gly Ile Phe Asn Tyr Ile Thr Gln
950 955 960TTT GTG AAT ATC TGC CAA GAA GAA GAA GAC GAA AAC GCC TTA AAA AAC 2984Phe Val Asn Ile Cys Gln Glu Glu Glu Asp Glu Asn Ala Leu Lys Asn
965 970 975CCC TTA AGC GAA GCC TTA GAA AAC TTA ACT CAA AAA GGC TAT GAT GAG 3032Pro Leu Ser Glu Ala Leu Glu Asn Leu Thr Gln Lys Gly Tyr Asp Glu
980 985 990CAT ACG CAT GAG TTG AAG CGC GCG ATT TTT ATG GCA AAA AGC TAC GCT 3080His Thr His Glu Leu Lys Arg Ala Ile Phe Met Ala Lys Ser Tyr Ala
995 1000 1005TAT CAT TAC AAA CAT GAA TTC AGC CAA ACT AAA GAC TAT GTC AAA ATC 3128Tyr His Tyr Lys His Glu Phe Ser Gln Thr Lys Asp Tyr Val Lys Ile1010 1015 1020 1025AGA GGC GAA GAC AAC CTT TTT TCC TAC ACT AAA GTT AAA AGC GTG GGC 3176Arg Gly Glu Asp Asn Leu Phe Ser Tyr Thr Lys Val Lys Ser Val Gly
1030 1035 1040TAT CGC ATC ACC GAA AAG GAC ACT TTA AGC GAC ATG TTA GGC GTT GCT 3224Tyr Arg Ile Thr Glu Lys Asp Thr Leu Ser Asp Met Leu Gly Val Ala
1045 1050 1055TTA GCA TGT TTA ATT TCT CAA ATC CCT TTA ACG CTC AGC ATA GAA AAC 3272Leu Ala Cys Leu Ile Ser Gln Ile Pro Leu Thr Leu Ser Ile Glu Asn
1060 1065 1070GAA CGA ACG AAC AAA GAT TTA ACC TTT TTC TTA GAA TGC TTA AAA GCG 3320Glu Arg Thr Asn Lys Asp Leu Thr Phe Phe Leu Glu Cys Leu Lys Ala 1075 1080 1085CTC CAA GCA AGC GCC CCT ATT GTT TAT GAA AGC TTG CAA AAA TTT AGC 3368Leu Gln Ala Ser Ala Pro Ile Val Tyr Glu Ser Leu Gln Lys Phe Ser1090 1095 1100 1105GAG AAA TTG AAT ACT TTC AAT CGT GTC CGT TAT CTC AAA AGC GAT TTG 3416Glu Lys Leu Asn Thr Phe Asn Arg Val Arg Tyr Leu Lys Ser Asp Leu
1110 1115 1120GAT TTA TTG CAC GAA CAA GCG AGC GCT TTA GGG ATG GTT TTA GCC ACG 3464Asp Leu Leu His Glu Gln Ala Ser Ala Leu Gly Met Val Leu Ala Thr
1125 1130 1135GCT AAA CCA TGC CTA AAT GGG CGT TTT GAA TTG CTG TAT TAC CAC TTA 3512Ala Lys Pro Cys Leu Asn Gly Arg Phe Glu Leu Leu Tyr Tyr His Leu
1140 1145 1150GAG CGA TCG GTT AGC ATC TCT TAT CAC CGT TAT GGG AAT TTA GGC TCA 3560Glu Arg Ser Val Ser Ile Ser Tyr His Arg Tyr Gly Asn Leu Gly Ser 1155 1160 1165AGG GTT TTA AGG CAA CCC ACT TGC CAC AAA TCA TGC TGT GCT GAA AAA T 3609Arg Val Leu Arg Gln Pro Thr Cys His Lys Ser Cys Cys Ala Glu Lys1170 1175 1180 1185AAATATTGTA TTAAATAAGG AGATCAAAAT GGGACATGTT GTTTTAAGTA CCCCTAT 3666
(2) Sequence 616 data: (i) sequence characteristics: length (A): 1185 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 616: met Gln Lys Ile Ile Asp Asp Ser Leu Glu Leu Ala Lys Lys Leu Gln 151015 Asp Ser Ile Ser Asn His Leu Ser Asp Gln Glu Lys Ala Phe His Ser
20 25 30Lys Met Gln Lys Leu Leu Asn Asn Pro Glu Asn Lys Val Met Leu Ile
35 40 45Glu Leu Met Asp Arg Ser Phe Arg Cys Leu Asp Asn Lys Ala Arg Phe
50 55 60Glu Met Ile Glu His Val Leu Asp Lys Tyr Lys Ser Arg Glu Ile Phe65 70 75 80Ser Pro Phe Glu Lys Val Leu Leu Met Gly Phe Leu Ser Phe Gly Lys
85 90 95Met Leu Pro Asp Met Ser Val Pro Phe Phe Val Asn Lys Ile Arg Ser
100 105 110Asp Thr Lys Ala Met Val Leu Asp Gln Glu Glu Ser Gln Leu Lys Glu
115 120 125Arg Ile Leu Lys Arg Lys Asn Glu Lys Ile Ile Leu Asn Val Asn Phe
130 135 140Ile Gly Glu Glu Val Leu Gly Glu Glu Glu Ala Asn Ala Arg Phe Glu145 150 155 160Lys Tyr Ser Gln Ala Leu Lys Ser Asn Tyr Ile Gln Tyr Ile Ser Ile
165 170 175Lys Ile Thr Thr Ile Phe Ser Gln Ile Asn Ile Leu Asp Phe Glu Tyr
180 185 190Ser Lys Lys Glu Ile Val Lys Arg Leu Asp Ala Leu Tyr Ala Leu Ala
195 200 205Leu Glu Glu Glu Lys Lys Gln Gly Met Pro Lys Phe Ile Asn Leu Asp
210 215 220Met Glu Glu Phe Arg Asp Leu Glu Leu Thr Val Glu Ser Phe Met Glu225 230 235 240Ser Ile Ala Lys Phe Asp Leu Asn Ala Gly Ile Val Leu Gln Ala Tyr
245 250 255Ile Pro Asp Ser Tyr Glu Tyr Leu Lys Lys Leu His Ala Phe Ser Lys
260 265 270Glu Arg Val Leu Lys Gly Leu Lys Pro Ile Lys Ile Arg Phe Val Lys
275 280 285Gly Ala Asn Met Glu Ser Glu Glu Thr Ile Ala Ser Val Lys Asp Trp
290 295 300Ala Leu Pro Thr Phe Ser Asn Lys Gln Asp Thr Asp Ser Asn Tyr Asn305 310 315 320Lys Met Leu Asp Phe Val Leu Glu Gly Asp Asn Tyr Lys Tyr Ile His
325 330 335Ile Gly Ala Ala Ser His Asn Ile Phe Glu Ile Ala Tyr Val Tyr Thr
340 345 350Arg Ile His Ala Ile Asn Asp Pro Val Val Leu Glu His Phe Ser Phe
355 360 365Glu Met Leu Glu Gly Met Ser Leu Gln Ala Ser Gln Glu Leu Lys Glu
370 375 380Met His Lys Leu Ile Leu Tyr Ala Pro Val Cys Asp Glu Ala His Phe385 390 395 400Asn Asn Ala Ile Ala Tyr Leu Val Arg Arg Leu Asp Glu Asn Thr Ser
405 410 415Ser Asp Asn Phe Met Lys Ala Phe Phe Asn Leu Lys Val Gly Thr Ser
420 425 430Glu Trp Lys Asp Gln Glu Gln Arg Phe Leu Asn Ser Leu Lys Gly Ile
435 440 445Ala Thr Leu Asp Asn Ala Thr His Arg Thr Gln Asp Arg Asn Ala Lys
450 455 460Gln Ser Gly His Thr Thr Tyr Pro Asn His Ser Phe Lys Asn Glu Ser465 470 475 480Asp Thr Asp Phe Ile Leu Lys Ala Asn Arg Glu Trp Ala Lys Lys Val
485 490 495Arg Glu Lys Met Arg Asn Ala Pro Ile Leu Glu Leu Tyr Pro Glu Met
500 505 510Asp Gly Arg Phe Glu Asp Pro Asn Leu Thr Pro Leu Glu Val Phe Asp
515 520 525Arg Ile His His Lys Lys Ile Ala Ser Val His Leu Ala Asp Lys Glu
530 535 540Ala Ile Leu Lys Ala Leu Glu Val Ala Lys Ser Asp Lys Ser Arg Phe545 550 555 560Ser Gln Lys Ser Phe Thr Glu Ile His Ala Leu Met Ser Gln Thr Ala
565 570 575Gln Leu Phe Arg Glu Arg Arg Gly Asp Leu Ile Gly Ile Ser Ala Leu
580 585 590Glu Val Gly Lys Thr Phe Ala Glu Thr Asp Ala Glu Val Ser Glu Ala
595 600 605Ile Asp Phe Leu Glu Phe Tyr Pro Tyr Ser Leu Arg Val Leu Gln Glu
610 615 620Gln Asn Thr Lys Thr Gln Phe Thr Pro Lys Gly Val Gly Val Val Ile625 630 635 640Ala Pro Trp Asn Phe Pro Val Gly Ile Ser Val Gly Thr Ile Ala Ala
645 650 655Pro Leu Ala Thr Gly Asn Arg Val Ile Tyr Lys Pro Ser Ser Leu Ser
660 665 670Ser Val Thr Gly Tyr Lys Leu Cys Glu Cys Phe Trp Asp Ala Gly Val
675 680 685Pro Arg Asp Ala Leu Ile Tyr Leu Pro Ser Lys Gly Ser Asp Ile Ser
690 695 700Glu His Leu Leu Arg Asp Glu Ser Ile Gln Phe Ala Ile Leu Thr Gly705 710 715 720Gly Glu Asp Thr Ala Tyr Lys Met Leu Lys Ala Asn Pro Thr Leu Ala
725 730 735Leu Ser Ala Glu Thr Gly Gly Lys Asn Ala Thr Ile Val Ser Lys Met
740 745 750Ala Asp Arg Asp Gln Ala Ile Lys Asn Val Ile His Ser Ala Phe Ser
755 760 765Asn Ser Gly Gln Lys Cys Ser Ala Thr Ser Leu Leu Val Leu Glu Lys
770 775 780Glu Val Tyr Glu Asp Glu Asn Phe Lys Lys Thr Leu Ile Asp Ala Thr785 790 795 800Leu Ser Leu Ser Val Gly Asp Pro Phe Asp Phe Lys Asn Lys Ile Gly
805 810 815Ala Leu Ala Asp Lys Pro Asn Glu Lys Val Ile Lys Ala Ile Asp Glu
820 825 830Leu Lys Ser Tyr Glu Asn Tyr Glu Ile Pro Val Ser Phe Val Asn Asp
835 840 845Asn Pro Tyr Leu Met Lys Pro Ser Ile Lys Tyr Gly Thr Lys Lys Gly
850 855 860Asp Phe Thr His Gln Thr Glu Leu Phe Thr Pro Ile Leu Ser Val Met865 870 875 880Glu Ala Lys Asp Leu Asp Glu Ala Ile Glu Ile Ala Asn Ser Thr Gly
885 890 895Tyr Gly Leu Thr Ser Ala Leu Glu Ser Leu Asp Glu Arg Glu Trp Glu
900 905 910Tyr Tyr Leu Glu Arg Ile Glu Ala Gly Asn Ile Tyr Ile Asn Lys Pro
915 920 925Thr Thr Gly Ala Ile Val Leu Arg Gln Pro Phe Gly Gly Val Lys Lys
930 935 940Ser Ala Val Gly Phe Gly Arg Lys Val Gly Ile Phe Asn Tyr Ile Thr945 950 955 960Gln Phe Val Asn Ile Cys Gln Glu Glu Glu Asp Glu Asn Ala Leu Lys
965 970 975Asn Pro Leu Ser Glu Ala Leu Glu Asn Leu Thr Gln Lys Gly Tyr Asp
980 985 990Glu His Thr His Glu Leu Lys Arg Ala Ile Phe Met Ala Lys Ser Tyr
995 1000 1005Ala Tyr His Tyr Lys His Glu Phe Ser Gln Thr Lys Asp Tyr Val Lys 1010 1015 1020Ile Arg Gly Glu Asp Asn Leu Phe Ser Tyr Thr Lys Val Lys Ser Val025 1030 1035 1040Gly Tyr Arg Ile Thr Glu Lys Asp Thr Leu Ser Asp Met Leu Gly Val
1045 1050 1055Ala Leu Ala Cys Leu Ile Ser Gln Ile Pro Leu Thr Leu Ser Ile Glu
1060 1065 1070Asn Glu Arg Thr Asn Lys Asp Leu Thr Phe Phe Leu Glu Cys Leu Lys
1075 1080 1085Ala Leu Gln Ala Ser Ala Pro Ile Val Tyr Glu Ser Leu Gln Lys Phe 1090 1095 1100Ser Glu Lys Leu Asn Thr Phe Asn Arg Val Arg Tyr Leu Lys Ser Asp105 1110 1115 1120Leu Asp Leu Leu His Glu Gln Ala Ser Ala Leu Gly Met Val Leu Ala
1125 1130 1135Thr Ala Lys Pro Cys Leu Asn Gly Arg Phe Glu Leu Leu Tyr Tyr His
1140 1145 1150Leu Glu Arg Ser Val Ser Ile Ser Tyr His Arg Tyr Gly Asn Leu Gly
1155 1160 1165Ser Arg Val Leu Arg Gln Pro Thr Cys His Lys Ser Cys Cys Ala Glu 1170 1175 1180Lys185
(2) Sequence 617 data: (i) sequence characteristics: length (A): 810bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 673 (D) other information: (xi) Description of the sequence: sequence 617: AGCATGAAGA AGTGGATGTG AAGGTGTGCA GTATAGATTC ACAAAGCATT AAAGTGGGGC 60TGTTTAAAGA TAACCAATTA ATCTATGAAA GCGAGGCAGA AAAATT ATG ATG ACT 115
Met Met Thr
1AAG AAC GCG TAT GCG TTT GTT GTG ATT GAA GAA AGC GTT ATG GTG TTT 163Lys Asn Ala Tyr Ala Phe Val Val Ile Glu Glu Ser Val Met Val Phe
5 10 15AAA CGC ACC AAA GAT GAG GGG TTA ATG CCT ATC TTT GAA GGC TTT GTG 211Lys Arg Thr Lys Asp Glu Gly Leu Met Pro Ile Phe Glu Gly Phe Val20 25 30 35CCT TTA AAA GAG GGC TTT TTG AAA AGT TTT AAA GAG CGT TGC AAT TTG 259Pro Leu Lys Glu Gly Phe Leu Lys Ser Phe Lys Glu Arg Cys Asn Leu
40 45 50GAA TTT TTA GAA AAT TTA GAC CTT TTG TTT TTG TAT GAC AAA CCA TCC 307Glu Phe Leu Glu Asn Leu Asp Leu Leu Phe Leu Tyr Asp Lys Pro Ser
55 60 65GCA CAC GAG ATC TTT TCC TTG TGC AAG GAG CTG AAA AAT TCC ATC TGG 355Ala His Glu Ile Phe Ser Leu Cys Lys Glu Leu Lys Asn Ser Ile Trp
70 75 80GAC AGG AAG CTT GTG GTA GCG CTA GTG GAG GCT TTA GAG GGG TTT AAG 403Asp Arg Lys Leu Val Val Ala Leu Val Glu Ala Leu Glu Gly Phe Lys
85 90 95GAT TGG AAT TTG TCG CTT AAA ATA GAA GAC AAG CGT TCT AAC AGC TTG 451Asp Trp Asn Leu Ser Leu Lys Ile Glu Asp Lys Arg Ser Asn Ser Leu100 105110 115GGT AAT GGC ACC AAA AAA TTG CTC ACC AAC GCT GAT TTA GGG AGC GAC 499Gly Asn Gly Thr Lys Lys Leu Leu Thr Asn Ala Asp Leu Gly Ser Asp
120 125 130TAT AAA ACA ATC GTG ATA GAC AGC ATG AAA ACA TAC CAC CAA AGC CAG 547Tyr Lys Thr Ile Val Ile Asp Ser Met Lys Thr Tyr His Gln Ser Gln
135 140 145CAA GAA AAA TAT AAA AGA GAA AGA GGC GAA ACG CTA GAG GTT CGC CCC 595Gln Glu Lys Tyr Lys Arg Glu Arg Gly Glu Thr Leu Glu Val Arg Pro
150 155 160ACA ACA CCC CCT AGC TAT GGG GGT GGA AGC ATT AGA ATC AGC GGC GAT 643Thr Thr Pro Pro Ser Tyr Gly Gly Gly Ser Ile Arg Ile Ser Gly Asp
165170175 AAA AAG CCT GAT TTT GAT GAA GAA AAT TTT TAAAAGAAAG GACAACCGAT GAG 696Lys Lys Pro Asp Phe Asp Glu Glu Asn Phe 180185 CAGAGTGCAA ATGGATACCG AAGAGGTCAG GGAATTTGTA GGGCATTTAG AACGCTTTAA 756AGAGTTACTA AGAGAGGAAG TGAACAGCTT GAGTAATCAT TTCCATAATT TAGA 810(2) sequence 618 data: (i) sequence characteristics: length (A): 189 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 618: met Met Thr Lys Asn Ala Tyr Ala Phe Val Val Ile Glu Glu Ser Val 151015 Met Val Phe Lys Arg Thr Lys Asp Glu Gly Leu Met Pro Ile Phe Glu
20 25 30Gly Phe Val Pro Leu Lys Glu Gly Phe Leu Lys Ser Phe Lys Glu Arg
35 40 45Cys Asn Leu Glu Phe Leu Glu Asn Leu Asp Leu Leu Phe Leu Tyr Asp
50 55 60Lys Pro Ser Ala His Glu Ile Phe Ser Leu Cys Lys Glu Leu Lys Asn65 70 75 80Ser Ile Trp Asp Arg Lys Leu Val Val Ala Leu Val Glu Ala Leu Glu
85 90 95Gly Phe Lys Asp Trp Asn Leu Ser Leu Lys Ile Glu Asp Lys Arg Ser
100 105 110Asn Ser Leu Gly Asn Gly Thr Lys Lys Leu Leu Thr Asn Ala Asp Leu
115 120 125Gly Ser Asp Tyr Lys Thr Ile Val Ile Asp Ser Met Lys Thr Tyr His
130 135 140Gln Ser Gln Gln Glu Lys Tyr Lys Arg Glu Arg Gly Glu Thr Leu Glu145 150 155 160Val Arg Pro Thr Thr Pro Pro Ser Tyr Gly Gly Gly Ser Ile Arg Ile
165 170 175Ser Gly Asp Lys Lys Pro Asp Phe Asp Glu Glu Asn Phe
180 185
(2) Sequence 619 data: (i) sequence characteristics: length (A): 940bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 58...852 (D) other information: (xi) Description of the sequence: sequence 619: AGAAGGCTTA GACGATGTGA TCGCTTGGAT CAAGCGCAAC GCTTTATTGG AAGATTG ATG 60
Met
1AAC ACT TAC GCT CAA GAA TCC AAG CTC AGG TTA AAA ACC AAA ATA GGG 108Asn Thr Tyr Ala Gln Glu Ser Lys Leu Arg Leu Lys Thr Lys Ile Gly
5 10 15GCT GAT GGG CGG TGC GTG ATT GAA GAC AAT TTT TTC ACG CCC CCC TTT 156Ala Asp Gly Arg Cys Val Ile Glu Asp Asn Phe Phe Thr Pro Pro Phe
2025 30AAG CTC ATG GCG CCC TTT TAC CCT AAA GAC GAT TTA GCG GAA ATC ATG 204Lys Leu Met Ala Pro Phe Tyr Pro Lys Asp Asp Leu Ala Glu Ile Met
35 40 45CTT TTA GCG GTA AGC CCT GGC ATG ATG AGG GGC GAT GCG CAA GAT GTG 252Leu Leu Ala Val Ser Pro Gly Met Met Arg Gly Asp Ala Gln Asp Val50 55 60 65CAA TTA AAC ATC GGT CCA AAT TGC AAG TTA AGG ATC ACT TCG CAA TCC 300Gln Leu Asn Ile Gly Pro Asn Cys Lys Leu Arg Ile Thr Ser Gln Ser
70 75 80TTT GAA AAA ATC CAT AAC ACT GAA GAT GGG TTT GCC AGC AGA GAC ATG 348Phe Glu Lys Ile His Asn Thr Glu Asp Gly Phe Ala Ser Arg Asp Met
85 90 95CAT ATT GTT GTG GGG GAA AAC GCT TTT TTA GAT TTT GCG CCT TTC CCG 396His Ile Val Val Gly Glu Asn Ala Phe Leu Asp Phe Ala Pro Phe Pro
100 105 110TTA ATC CCC TTT GAA AAC GCG CAT TTT AAG GGC AAC ACC ACG ATT TCT 444Leu Ile Pro Phe Glu Asn Ala His Phe Lys Gly Asn Thr Thr Ile Ser
115 120 125TTG CGC TCT AGC TCT CAA TTG CTC TAT AGT GAA ATC ATT GTC GCA GGG 492Leu Arg Ser Ser Ser Gln Leu Leu Tyr Ser Glu Ile Ile Val Ala Gly130 135 140 145CGA GTG GCG CGC AAT GAG TTG TTT AAA TTC AAC CGC TTG CAC ACC AAA 540Arg Val Ala Arg Asn Glu Leu Phe Lys Phe Asn Arg Leu His Thr Lys
150 155 160ATC TCT ATT TTA CAA GAT GAG AAA CCC ATC TAT TAT GAC AAC ACG ATT 588Ile Ser Ile Leu Gln Asp Glu Lys Pro Ile Tyr Tyr Asp Asn Thr Ile
165 170 175TTA GAT CCC AAA ACC ACC GAC TTA AAT AAC ATG TGC ATG TTT GAT GGC 636Leu Asp Pro Lys Thr Thr Asp Leu Asn Asn Met Cys Met Phe Asp Gly
180 185 190TAT ACG CAT TAT TTG AAT TTG GTG CTT GTC AAT TGC CCC ATA GAG CTC 684Tyr Thr His Tyr Leu Asn Leu Val Leu Val Asn Cys Pro Ile Glu Leu
195 200 205TCT GGT GTG CGA GAA TGC ATT GAA GAA AGC GAA GGG GTG GAT GGG GCA 732Ser Gly Val Arg Glu Cys Ile Glu Glu Ser Glu Gly Val Asp Gly Ala210 215 220 225GTG AGT GAA ACC GCT AGT TCT CAT TTA TGC GTG AAA GCT TTA GCG AAA 780Val Ser Glu Thr Ala Ser Ser His Leu Cys Val Lys Ala Leu Ala Lys
230 235 240GGC TCA GAA CCC TTA TTG CAT TTA AGA GAA AAA ATC GCT CGC TTG GTT 828Gly Ser Glu Pro Leu Leu His Leu Arg Glu Lys Ile Ala Arg Leu Val
245 250 255ACG CAA ACC ACC ACG CAA AAG GTT TGAAAGCACT TCAAAAAGAT TAAAGTCCTT 882Thr Gln Thr Thr Thr Gln Lys Val
260265 TAGTCTTTTT ACTCCCCCCT TTTTTTGACC CTATAAGCTG AAAGGCCTGA ATTCAGTA 940 (940) (2) sequence 620 data: (i) sequence characteristics: length (A): 265 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 620: met Asn Thr Tyr Ala Gln Glu Ser Lys Leu Arg Leu Lys Thr Lys Ile 151015 Gly Ala Asp Gly Arg Cys Val Ile Glu Asp Asn Phe Phe Thr Pro Pro
20 25 30Phe Lys Leu Met Ala Pro Phe Tyr Pro Lys Asp Asp Leu Ala Glu Ile
35 40 45Met Leu Leu Ala Val Ser Pro Gly Met Met Arg Gly Asp Ala Gln Asp
50 55 60Val Gln Leu Asn Ile Gly Pro Asn Cys Lys Leu Arg Ile Thr Ser Gln65 70 75 80Ser Phe Glu Lys Ile His Asn Thr Glu Asp Gly Phe Ala Ser Arg Asp
85 90 95Met His Ile Val Val Gly Glu Asn Ala Phe Leu Asp Phe Ala Pro Phe
100 105 110Pro Leu Ile Pro Phe Glu Asn Ala His Phe Lys Gly Asn Thr Thr Ile
115 120 125Ser Leu Arg Ser Ser Ser Gln Leu Leu Tyr Ser Glu Ile Ile Val Ala
130 135 140Gly Arg Val Ala Arg Asn Glu Leu Phe Lys Phe Asn Arg Leu His Thr145 150 155 160Lys Ile Ser Ile Leu Gln Asp Glu Lys Pro Ile Tyr Tyr Asp Asn Thr
165 170 175Ile Leu Asp Pro Lys Thr Thr Asp Leu Asn Asn Met Cys Met Phe Asp
180 185 190Gly Tyr Thr His Tyr Leu Asn Leu Val Leu Val Asn Cys Pro Ile Glu
195 200 205Leu Ser Gly Val Arg Glu Cys Ile Glu Glu Ser Glu Gly Val Asp Gly
210 215 220Ala Val Ser Glu Thr Ala Ser Ser His Leu Cys ValLys Ala Leu Ala225 230 235 240Lys Gly Ser Glu Pro Leu Leu His Leu Arg Glu Lys Ile Ala Arg Leu
245 250 255Val Thr Gln Thr Thr Thr Gln Lys Val
260 265
(2) Data of sequence 621: (i) sequence characteristics: length (A): 1815bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1757 (D) other information: (xi) Description of the sequence: sequence 621: ATGGCGCTAA AAGCGATGAC AACTATGTAA AAACAATTAA GGAGTAAGAA ATG AAA 56
Met Lys
1AAG ATT AGC AGA AAA GAA TAT GTT TCT ATG TAT GGC CCT ACT ACA GGC 104Lys Ile Ser Arg Lys Glu Tyr Val Ser Met Tyr Gly Pro Thr Thr Gly
5 10 15GAT AAA GTG AGA TTG GGC GAT ACA GAC TTG ATC GCT GAA GTA GAA CAT 152Asp Lys Val Arg Leu Gly Asp Thr Asp Leu Ile Ala Glu Val Glu His
20 25 30GAC TAC ACC ATT TAT GGC GAA GAG CTT AAA TTC GGT GGC GGT AAA ACC 200Asp Tyr Thr Ile Tyr Gly Glu Glu Leu Lys Phe Gly Gly Gly Lys Thr35 40 45 50CTG AGA GAA GGC ATG AGC CAA TCC AAC AAC CCT AGC AAA GAA GAA TTG 248Leu Arg Glu Gly Met Ser Gln Ser Asn Asn Pro Ser Lys Glu Glu Leu
55 60 65GAT CTA ATC ATC ACT AAC GCT TTA ATC GTG GAT TAC ACC GGT ATT TAT 296Asp Leu Ile Ile Thr Asn Ala Leu Ile Val Asp Tyr Thr Gly Ile Tyr
70 75 80AAA GCG GAT ATT GGT ATT AAA GAT GGC AAA ATC GCT GGC ATT GGT AAA 344Lys Ala Asp Ile Gly Ile Lys Asp Gly Lys Ile Ala Gly Ile Gly Lys
85 90 95GGC GGT AAC AAA GAC ATG CAA GAT GGC GTT AAA AAC AAT CTT AGC GTA 392Gly Gly Asn Lys Asp Met Gln Asp Gly Val Lys Asn Asn Leu Ser Val
100 105 110GGT CCT GCT ACT GAA GCC TTA GCC GGT GAA GGT TTG ATC GTA ACT GCT 440Gly Pro Ala Thr GluAla Leu Ala Gly Glu Gly Leu Ile Val Thr Ala115 120 125 130GGT GGT ATT GAC ACA CAC ATC CAC TTC ATT TCA CCC CAA CAA ATC CCT 488Gly Gly Ile Asp Thr His Ile His Phe Ile Ser Pro Gln Gln Ile Pro
135 140 145ACA GCT TTT GCA AGC GGT GTA ACA ACC ATG ATT GGT GGC GGA ACT GGT 536Thr Ala Phe Ala Ser Gly Val Thr Thr Met Ile Gly Gly Gly Thr Gly
150 155 160CCT GCT GAT GGC ACT AAT GCG ACT ACT ATC ACT CCA GGC AGA AGA AAT 584Pro Ala Asp Gly Thr Asn Ala Thr Thr Ile Thr Pro Gly Arg Arg Asn
165 170 175TTA AAA TGG ATG CTC AGA GCG GCT GAA GAA TAT TCT ATG AAC TTA GGT 632Leu Lys Trp Met Leu Arg Ala Ala Glu Glu Tyr Ser Met Asn Leu Gly
180 185 190TTC TTG GCT AAA GGT AAC GCT TCT AAC GAC GCG AGC TTA GCC GAT CAA 680Phe Leu Ala Lys Gly Asn Ala Ser Asn Asp Ala Ser Leu Ala Asp Gln195 200 205 210ATT GAA GCT GGT GCG ATT GGC TTT AAA ATC CAC GAA GAC TGG GGC ACC 728Ile Glu Ala Gly Ala Ile Gly Phe Lys Ile His Glu Asp Trp Gly Thr
215 220 225ACT CCT TCT GCA ATC AAT CAT GCG TTA GAT GTT GCA GAC AAA TAC GAT 776Thr Pro Ser Ala Ile Asn His Ala Leu Asp Val Ala Asp Lys Tyr Asp
230 235 240GTG CAA GTC GCT ATC CAC ACA GAC ACT TTG AAT GAA GCC GGT TGC GTG 824Val Gln Val Ala Ile His Thr Asp Thr Leu Asn Glu Ala Gly Cys Val
245 250 255GAA GAC ACT ATG GCA GCT ATT GCC GGA CGC ACT ATG CAC ACT TTC CAC 872Glu Asp Thr Met Ala Ala Ile Ala Gly Arg Thr Met His Thr Phe His
260 265 270ACT GAA GGT GCT GGC GGC GGA CAC GCT CCT GAT ATT ATT AAA GTA GCT 920Thr Glu Gly Ala Gly Gly Gly His Ala Pro Asp Ile Ile Lys Val Ala275 280 285 290GGT GAA CAC AAC ATT CTT CCC GCT TCC ACT AAC CCC ACT ATC CCT TTC 968Gly Glu His Asn Ile Leu Pro Ala Ser Thr Asn Pro Thr Ile Pro Phe
295 300 305ACT GTG AAT ACA GAA GCA GAA CAC ATG GAC ATG CTT ATG GTG TGC CAC 1016Thr Val Asn Thr Glu Ala Glu His Met Asp Met Leu Met Val Cys His
310 315 320CAC TTG GAT AAA AGC ATT AAA GAA GAT GTT CAG TTC GCT GAT TCA AGG 1064His Leu Asp Lys Ser Ile Lys Glu Asp Val Gln Phe Ala Asp Ser Arg
325 330 335ATC CGC CCT CAA ACC ATT GCG GCT GAA GAC ACT TTG CAT GAC ATG GGG 1112Ile Arg Pro Gln Thr Ile Ala Ala Glu Asp Thr Leu His Asp Met Gly
340 345 350ATT TTC TCA ATC ACC AGC TCT GAC TCT CAA GCT ATG GGT CGT GTG GGT 1160Ile Phe Ser Ile Thr Ser Ser Asp Ser Gln Ala Met Gly Arg Val Gly355 360 365 370GAA GTT ATC ACT AGA ACT TGG CAA ACA GCT GAC AAA AAC AAA AAA GAA 1208Glu Val Ile Thr Arg Thr Trp Gln Thr Ala Asp Lys Asn Lys Lys Glu
375 380 385TTT GGC CGC TTG AAA GAA GAA AAA GGC GAT AAC GAC AAC TTC AGG ATC 1256Phe Gly Arg Leu Lys Glu Glu Lys Gly Asp Asn Asp Asn Phe Arg Ile
390 395 400AAA CGC TAC TTG TCT AAA TAC ACC ATT AAC CCA GCG ATC GCT CAT GGG 1304Lys Arg Tyr Leu Ser Lys Tyr Thr Ile Asn Pro Ala Ile Ala His Gly
405 410 415ATT AGC GAG TAT GTA GGT TCT GTA GAA GTG GGC AAA GTG GCT GAC TTG 1352Ile Ser Glu Tyr Val Gly Ser Val Glu Val Gly Lys Val Ala Asp Leu
420 425 430GTA TTG TGG AGT CCC GCA TTC TTT GGC GTA AAA CCC AAC ATG ATC ATC 1400Val Leu Trp Ser Pro Ala Phe Phe Gly Val Lys Pro Asn Met Ile Ile435 440 445 450AAA GGC GGG TTC ATT GCG TTG AGT CAA ATG GGT GAC GCG AAC GCT TCT 1448Lys Gly Gly Phe Ile Ala Leu Ser Gln Met Gly Asp Ala Asn Ala Ser
455 460 465ATC CCT ACC CCA CAA CCA GTT TAT TAC AGA GAA ATG TTC GCT CAT CAT 1496Ile Pro Thr Pro Gln Pro Val Tyr Tyr Arg Glu Met Phe Ala His His
470 475 480GGT AAA GCC AAA TAC GAT GCA AAC ATC ACT TTT GTG TCT CAA GCG GCT 1544Gly Lys Ala Lys Tyr Asp Ala Asn Ile Thr Phe Val Ser Gln Ala Ala
485 490 495TAT GAC AAA GGC ATT AAA GAA GAA TTA GGG CTT GAA AGA CAA GTG TTG 1592Tyr Asp Lys Gly Ile Lys Glu Glu Leu Gly Leu Glu Arg Gln Val Leu
500 505 510CCG GTA AAA AAT TGC AGA AAC ATC ACT AAA AAA GAC ATG CAA TTC AAC 1640Pro Val Lys Asn Cys Arg Asn Ile Thr Lys Lys Asp Met Gln Phe Asn515 520 525 530GAC ACT ACC GCT CAC ATT GAA GTC AAT CCT GAA ACT TAC CAT GTG TTC 1688Asp Thr Thr Ala His Ile Glu Val Asn Pro Glu Thr Tyr His Val Phe
535 540 545GTG GAT GGC AAA GAA GTA ACT TCT AAA CCA GCC AAT AAA GTG AGC TTG 1736Val Asp Gly Lys Glu Val Thr Ser Lys Pro Ala Asn Lys Val Ser Leu
550 555 560GCG CAA CTC TTT AGC ATT TTC TAGGATTTTT TAGGAGCAAC GCTCCTTAAA TCCT 1791Ala Gln Leu Phe Ser Ile Phe
565TAGTTTTTAG CTCTCTGATT TTTT 1815
(2) Sequence 622 data: (i) sequence characteristics: length (A): 569 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 622: met Lys Lys Ile Ser Arg Lys Glu Tyr Val Ser Met Tyr Gly Pro Thr 151015 Thr Gly Asp Lys Val Arg Leu Gly Asp Thr Asp Leu Ile Ala Glu Val
20 25 30Glu His Asp Tyr Thr Ile Tyr Gly Glu Glu Leu Lys Phe Gly Gly Gly
35 40 45Lys Thr Leu Arg Glu Gly Met Ser Gln Ser Asn Asn Pro Ser Lys Glu
50 55 60Glu Leu Asp Leu Ile Ile Thr Asn Ala Leu Ile Val Asp Tyr Thr Gly65 70 75 80Ile Tyr Lys Ala Asp Ile Gly Ile Lys Asp Gly Lys Ile Ala Gly Ile
85 90 95Gly Lys Gly Gly Asn Lys Asp Met Gln Asp Gly Val Lys Asn Asn Leu
100 105 110Ser Val Gly Pro Ala Thr Glu Ala Leu Ala Gly Glu Gly Leu Ile Val
115 120 125Thr Ala Gly Gly Ile Asp Thr His Ile His Phe Ile Ser Pro Gln Gln
130 135 140Ile Pro Thr Ala Phe Ala Ser Gly Val Thr Thr Met Ile Gly Gly Gly145 150 155 160Thr Gly Pro Ala Asp Gly Thr Asn Ala Thr Thr Ile Thr Pro Gly Arg
165 170 175Arg Asn Leu Lys Trp Met Leu Arg Ala Ala Glu Glu Tyr Ser Met Asn
180 185190Leu Gly Phe Leu Ala Lys Gly Asn Ala Ser Asn Asp Ala Ser Leu Ala
195 200 205Asp Gln Ile Glu Ala Gly Ala Ile Gly Phe Lys Ile His Glu Asp Trp
210 215 220Gly Thr Thr Pro Ser Ala Ile Asn His Ala Leu Asp Val Ala Asp Lys225 230 235 240Tyr Asp Val Gln Val Ala Ile His Thr Asp Thr Leu Asn Glu Ala Gly
245 250 255Cys Val Glu Asp Thr Met Ala Ala Ile Ala Gly Arg Thr Met His Thr
260 265 270Phe His Thr Glu Gly Ala Gly Gly Gly His Ala Pro Asp Ile Ile Lys
275 280 285Val Ala Gly Glu His Asn Ile Leu Pro Ala Ser Thr Asn Pro Thr Ile
290 295 300Pro Phe Thr Val Asn Thr Glu Ala Glu His Met Asp Met Leu Met Val305 3l0 315 320Cys His His Leu Asp Lys Ser Ile Lys Glu Asp Val Gln Phe Ala Asp
325 330 335Ser Arg Ile Arg Pro Gln Thr Ile Ala Ala Glu Asp Thr Leu His Asp
340 345 350Met Gly Ile Phe Ser Ile Thr Ser Ser Asp Ser Gln Ala Met Gly Arg
355 360 365Val Gly Glu Val Ile Thr Arg Thr Trp Gln Thr Ala Asp Lys Asn Lys
370 375 380Lys Glu Phe Gly Arg Leu Lys Glu Glu Lys Gly Asp Asn Asp Asn Phe385 390 395 400Arg Ile Lys Arg Tyr Leu Ser Lys Tyr Thr Ile Asn Pro Ala Ile Ala
405 410415His Gly Ile Ser Glu Tyr Val Gly Ser Val Glu Val Gly Lys Val Ala
420 425 430Asp Leu Val Leu Trp Ser Pro Ala Phe Phe Gly Val Lys Pro Asn Met
435 440 445Ile Ile Lys Gly Gly Phe Ile Ala Leu Ser Gln Met Gly Asp Ala Asn
450 455 460Ala Ser Ile Pro Thr Pro Gln Pro Val Tyr Tyr Arg Glu Met Phe Ala465 470 475 480His His Gly Lys Ala Lys Tyr Asp Ala Asn Ile Thr Phe Val Ser Gln
485 490 495Ala Ala Tyr Asp Lys Gly Ile Lys Glu Glu Leu Gly Leu Glu Arg Gln
500 505 510Val Leu Pro Val Lys Asn Cys Arg Asn Ile Thr Lys Lys Asp Met Gln
515 520 525Phe Asn Asp Thr Thr Ala His Ile Glu Val Asn Pro Glu Thr Tyr His
530 535 540Val Phe Val Asp Gly Lys Glu Val Thr Ser Lys Pro Ala Asn Lys Val545 550 555 560Ser Leu Ala Gln Leu Phe Ser Ile Phe
565
(2) Sequence 623 data: (i) sequence characteristics: length (A): 934bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 51 … 881 (D) other information: (xi) Description of the sequence: sequence 623: GAGATCTACA ATTTGAGCAA TGTAAATGAT TTTATATCAA AGGCACAAAA ATG GTA 56
Met Val
1ATCGCG CAT TCT AAT GAA ATC GCA CGC CCC ATT TTT AAA AGC CAA GAC 104Ile Ala His Ser Asn Glu Ile Ala Arg Pro Ile Phe Lys Ser Gln Asp
5 10 15CAG CTT TTC ACT CTT TAT CAA GGG GAT TGT AAT GAG GTT TTG CCC CAA 152Gln Leu Phe Thr Leu Tyr Gln Gly Asp Cys Asn Glu Val Leu Pro Gln
20 25 30TTT GAA AAC CAG TTT GAT TTG ATT TTT GCT GAT CCG CCT TAT TTC CTC 200Phe Glu Asn Gln Phe Asp Leu Ile Phe Ala Asp Pro Pro Tyr Phe Leu35 40 45 50TCT AAT GAC GGC TTA AGC ATA CAG AGC GGT AAA ATC GTG AGC GTC AAT 248Ser Asn Asp Gly Leu Ser Ile Gln Ser Gly Lys Ile Val Ser Val Asn
55 60 65AAA GGC GAT TGG GAT AAA GAA GAT GGG ATT AAT GGT ATT GAT GAG TTT 296Lys Gly Asp Trp Asp Lys Glu Asp Gly Ile Asn Gly Ile Asp Glu Phe
70 75 80AAT TAC CAG TGG ATA AAC AAC GCT AAA AAG GCT TTA AAA GAC ACA GGA 344Asn Tyr Gln Trp Ile Asn Asn Ala Lys Lys Ala Leu Lys Asp Thr Gly
85 90 95AGC CTT TTA ATC AGC GGG ACT TAC CAC AAC ATC TTT TCT TTG GGG TGT 392Ser Leu Leu Ile Ser Gly Thr Tyr His Asn Ile Phe Ser Leu Gly Cys
100 105 110GTT TTA CAA AAA TTG GAT TTT AAG ATT TTA AAC CTC ATC ACC TGG CAA 440Val Leu Gln Lys Leu Asp Phe Lys Ile Leu Asn Leu Ile Thr Trp Gln115 120 125 130AAA ACC AAC CCT CCT CCC AAT TTC AGC TGC CGT TAT TTG ACG CAT TCA 488Lys Thr Asn Pro Pro Pro Asn Phe Ser Cys Arg Tyr Leu Thr His Ser
135 140 145GCT GAG CAA ATC ATT TGG GCG AGA AAA AGC CGC AAA CAC AAG CAT GTT 536Ala Glu Gln Ile Ile TrpAla Arg Lys Ser Arg Lys His Lys His Val
150 155 160TTT AAC TAT GAG GTT TTA AAA AAG ATC AAT AAC GAC AAG CAA ATG CGC 584Phe Asn Tyr Glu Val Leu Lys Lys Ile Asn Asn Asp Lys Gln Met Arg
165 170 175GAT GTG TGG AGC TTC CCA GCG ATC GCT CCT TGG GAA AAA GTT AAT GGC 632Asp Val Trp Ser Phe Pro Ala Ile Ala Pro Trp Glu Lys Val Asn Gly
180 185 190AAG CAC CCC ACT CAA AAA CCC CTC GCT TTA TTA GTG CGC TTG CTT TTA 680Lys His Pro Thr Gln Lys Pro Leu Ala Leu Leu Val Arg Leu Leu Leu195 200 205 210ATG GCG AGC GAT GAA AAT TCT CTC ATT GGC GAT CCT TTT AGC GGG AGC 728Met Ala Ser Asp Glu Asn Ser Leu Ile Gly Asp Pro Phe Ser Gly Ser
215 220 225TCT ACC ACA GGC ATT GCG GCT AAT CTT TTG AAG AGG GAA TTT ATT GGC 776Ser Thr Thr Gly Ile Ala Ala Asn Leu Leu Lys Arg Glu Phe Ile Gly
230 235 240ATA GAA AAA GAA AGC GAG TTT ATC AAA ATA TCC ATG GAT AGA AAA ATA 824Ile Glu Lys Glu Ser Glu Phe Ile Lys Ile Ser Met Asp Arg Lys Ile
245 250 255GAA TTA GAC GCT CGC TAT AAA GAA ATC CGA TCT AAA ATC AAA GAT TTA 872Glu Leu Asp Ala Arg Tyr Lys Glu Ile Arg Ser Lys Ile Lys Asp Leu
260 265 270AAC CAC CAA TAAAGCCTTT TTTTAAGCCA CTTTAAGCGT TATACTTTTG GGATTTTAC 930Asn His Gln275CTCA 934
(2) Data of sequence 624:
(i) sequence characteristics:
(A) length: 277 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 624: met Val Ile Ala His Ser Asn Glu Ile Ala Arg Pro Ile Phe Lys Ser 151015 Gln Asp Gln Leu Phe Thr Leu Tyr Gln Gly Asp Cys Asn Glu Val Leu
20 25 30Pro Gln Phe Glu Asn Gln Phe Asp Leu Ile Phe Ala Asp Pro Pro Tyr
35 40 45Phe Leu Ser Asn Asp Gly Leu Ser Ile Gln Ser Gly Lys Ile Val Ser
50 55 60Val Asn Lys Gly Asp Trp Asp Lys Glu Asp Gly Ile Asn Gly Ile Asp65 70 75 80Glu Phe Asn Tyr Gln Trp Ile Asn Asn Ala Lys Lys Ala Leu Lys Asp
85 90 95Thr Gly Ser Leu Leu Ile Ser Gly Thr Tyr His Asn Ile Phe Ser Leu
100 105 110Gly Cys Val Leu Gln Lys Leu Asp Phe Lys Ile Leu Asn Leu Ile Thr
115 120 125Trp Gln Lys Thr Asn Pro Pro Pro Asn Phe Ser Cys Arg Tyr Leu Thr
130 135 140His Ser Ala Glu Gln Ile Ile Trp Ala Arg Lys Ser Arg Lys His Lys145 150 155 160His Val Phe Asn Tyr Glu Val Leu Lys Lys Ile Asn Asn Asp Lys Gln
165 170 175Met Arg Asp Val Trp Ser Phe Pro Ala Ile Ala Pro Trp Glu Lys Val
180 185 190Asn Gly Lys His Pro Thr Gln Lys Pro Leu Ala Leu Leu Val Arg Leu
195 200 205Leu Leu Met Ala Ser Asp Glu Asn Ser Leu Ile Gly Asp Pro Phe Ser
210 215 220Gly Ser Ser Thr Thr Gly Ile Ala Ala Asn Leu Leu Lys Arg Glu Phe225 230 235 240Ile Gly Ile Glu Lys Glu Ser Glu Phe Ile Lys Ile Ser Met Asp Arg
245 250 255Lys Ile Glu Leu Asp Ala Arg Tyr Lys Glu Ile Arg Ser Lys Ile Lys
260 265 270Asp Leu Asn His Gln
275
(2) Sequence 625 data: (i) sequence characteristics: length (A): 646bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 588 (D) other information: (xi) Description of the sequence: sequence 625: CTTGACTTAT TTTTTTGGCT ATTTCCAAGA TCCACGATAC TTTGATGCTA TATCCCCTTT 60AATCAAGCAA ACCTTCACTC TACCCCCCCC CCCCCCGAAA ATAATAAGAA TAATAATAAA 120AAAGAGGAAG AATATCAGTG CAAGCTTTCT TTGATTTTAG CCGCTAAAAA CAGCGTGTTT 180GTGCATATAA GAAGAGGGGA TTATGTGGGG ATTGGCTGTC AGCTTGGTAT TGACTATCAA 240AAAAAGGCGC TTGAGTAT ATG GCA AAG CGC GTG CCA AAC ATG GAG CTT TTT 291
Met Ala Lys Arg Val Pro Asn Met Glu Leu Phe
1 5 10GTG TTT TGC GAA GAC TTA GAA TTC ACG CAA AAT CTT GAT CTT GGC TAC 339Val Phe Cys Glu Asp Leu Glu Phe Thr Gln Asn Leu Asp Leu Gly Tyr
15 20 25CCT TTT ATG GAC ATG ACC ACT AGG GAT AAA GAA GAA GAG GCG TAT TGG 387Pro Phe Met Asp Met Thr Thr Arg Asp Lys Glu Glu Glu Ala Tyr Trp
30 35 40GAC ATG CTG CTC ATG CAA TCT TGT CAG CAT GGC ATT ATC GCT AAT AGC 435Asp Met Leu Leu Met Gln Ser Cys Gln His Gly Ile Ile Ala Asn Ser
45 50 55ACT TAT AGC TGG TGG GCG GCC TAT TTG ATA GAA AAT CCA GAA AAA ATC 483Thr Tyr Ser Trp Trp Ala Ala Tyr Leu Ile Glu Asn Pro Glu Lys Ile60 65 70 75ATT ATT GGC CCC AAA CAC TGG CTT TTT GGG CAT GAG AAT ATC CTT TGT 531Ile Ile Gly Pro Lys His Trp Leu Phe Gly His Glu Asn Ile Leu Cys
80 85 90AAG GAG TGG GTG AAA ATA GAA TCC CAT TTT GAG GTA AAA TCC CAA AAG 579Lys Glu Trp Val Lys Ile Glu Ser His Phe Glu Val Lys Ser Gln Lys
95 100 105TAT AAC GCT TAAAGTGGCT TAAAAAAAGG CTTTATTGGT GGTTTAAATC TTTGATTTT 637Tyr Asn Ala
110AGATCGGAT 646
(2) Data of sequence 626: (i) sequence characteristics: length (A): 110 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 626: met Ala Lys Arg Val Pro Asn Met Glu Leu Phe Val Phe Cys Glu Asp 151015 Leu Glu Phe Thr Gln Asn Leu Asp Leu Gly Tyr Pro Phe Met Asp Met
20 25 30Thr Thr Arg Asp Lys Glu Glu Glu Ala Tyr Trp Asp Met Leu Leu Met
35 40 45Gln Ser Cys Gln His Gly Ile Ile Ala Asn Ser Thr Tyr Ser Trp Trp
50 55 60Ala Ala Tyr Leu Ile Glu Asn Pro Glu Lys Ile Ile Ile Gly Pro Lys6570 75 80His Trp Leu Phe Gly His Glu Asn Ile Leu Cys Lys Glu Trp Val Lys
85 90 95Ile Glu Ser His Phe Glu Val Lys Ser Gln Lys Tyr Asn Ala
100 105 110
(2) Data for sequence 627:
(i) sequence characteristics:
(A) length: 1027bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...974
(D) Other information: (xi) Description of the sequence: sequence 627: GGCGCATGAA TGCATTAAAT GTAAAGAACG CGTGTTTTTA GAGGAAGATA ATG GCT 56
Met Ala
1AAA GAA AAT CCG CCT ATC GTT TTT GGG CCT GTT TTA TCC AGG CGT TTT 104Lys Glu Asn Pro Pro Ile Val Phe Gly Pro Val Leu Ser Arg Arg Phe
5 10 15GGG AAG TCT TTG GGC GTG GAT CTA TCG CCC TCT AAA AAA CAA TGC AAT 152Gly Lys Ser Leu Gly Val Asp Leu Ser Pro Ser Lys Lys Gln Cys Asn
20 25 30TAC AAT TGC ATT TAT TGC GAG TTG GGT AAA GCC AAG CCC ATT GAA CGC 200Tyr Asn Cys Ile Tyr Cys Glu Leu Gly Lys Ala Lys Pro Ile Glu Arg35 40 45 50ATG GAA GAA GTG ATC AAA GTG GAA ACC TTG ATT AAC GCC ATT CAA AAC 248Met Glu Glu Val Ile Lys Val Glu Thr Leu Ile Asn Ala Ile Gln Asn
55 60 65GCC CTA AAC AAC CTC ACC ACC CCC ATT GAT GTT TTA ACC ATT ACC GCT 296Ala Leu Asn Asn Leu Thr Thr Pro Ile Asp Val Leu Thr Ile Thr Ala
70 75 80AAT GGC GAA CCC ACG CTA TAC CCT CAT TTA TTA GAG CTT ATC CAA AGC 344Asn Gly Glu Pro Thr Leu Tyr Pro His Leu Leu Glu Leu Ile Gln Ser
85 90 95ATC AAG CCT TTT TTA AAG GGC GTT AAA ACT TTG ATT TTA AGC AAT GGC 392Ile Lys Pro Phe Leu Lys Gly Val Lys Thr Leu Ile Leu Ser Asn Gly
100 105 110TCG CTC TTT TAT GAG CCA AAA GTC CAG CAA GCC TTA AAG GAA TTT GAC 440Ser Leu Phe Tyr Glu Pro Lys Val Gln Gln Ala Leu Lys Glu Phe Asp115 120 125 130ATC GTT AAA TTT TCT TTA GAC GCT ATT GAT TTG AAA GCC TTT GAA AGA 488Ile Val Lys Phe Ser Leu Asp Ala Ile Asp Leu Lys Ala Phe Glu Arg
135 140 145GTG GAT AAA CCC TAT TCT AAA GAC ATT AAT AAG ATT TTA GAG GGG ATT 536Val Asp Lys Pro Tyr Ser Lys Asp Ile Asn Lys Ile Leu Glu Gly Ile
150 155 160TTG CGC TTT TCT CAA ATT TAT CAA GGG CAA TTG GTG GCT GAA GTG TTG 584Leu Arg Phe Ser Gln Ile Tyr Gln Gly Gln Leu Val Ala Glu Val Leu
165 170 175TTA ATT AAG GGC GTG AAT GAT AGC GCG AAC AAC TTA AAA CTC ATC GCT 632Leu Ile Lys Gly Val Asn Asp Ser Ala Asn Asn Leu Lys Leu Ile Ala
180 185 190GCC TTT TTA AAA CAA ATC AAT ATA GCC AGA GTG GAT TTA AGC ACC ATA 680AlaPhe Leu Lys Gln Ile Asn Ile Ala Arg Val Asp Leu Ser Thr Ile195 200 205 210GAC AGA CCC TCA AGC TTT AAA GCC CCT AAA TTA AGC GAA GAT GAA TTG 728Asp Arg Pro Ser Ser Phe Lys Ala Pro Lys Leu Ser Glu Asp Glu Leu
215 220 225TTA AAA TGC TCT TTA TTT TTT GAA GGG CTT TGC GTG AGT TTG CCT AAA 776Leu Lys Cys Ser Leu Phe Phe Glu Gly Leu Cys Val Ser Leu Pro Lys
230 235 240CGA TCC ATT ACT CAA GCT AAA AAA TTG ATT TCT TGC GGT ATA GAC GAA 824Arg Ser Ile Thr Gln Ala Lys Lys Leu Ile Ser Cys Gly Ile Asp Glu
245 250 255TTG CTC GCT TTA ATT TCC AGG CGC CCT TTA AGC GCA GAA GAA GCC CCC 872Leu Leu Ala Leu Ile Ser Arg Arg Pro Leu Ser Ala Glu Glu Ala Pro
260 265 270CTA ATT CTA GAT TCT AAC GCT TTT AAG CAT TTA GAA ACT TTG TTA AAC 920Leu Ile Leu Asp Ser Asn Ala Phe Lys His Leu Glu Thr Leu Leu Asn275 280 285 290CAT AAG CAA ATT ACG ATT AAA AAA GTC GGC TCT TTG GAG TTT TAT TGC 968His Lys Gln Ile Thr Ile Lys Lys Val Gly Ser Leu Glu Phe Tyr Cys
295 300 305GCG TTT TAACCTCCAT TTGTAAGTTT TACCTTACTT TAGGGATAGC TTAAGCTTTT AA 1026Ala Phe
1027
(2) Sequence 628 data: (i) sequence characteristics: length (A): 308 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 628: met Ala Lys Glu Asn Pro Pro Ile Val Phe Gly Pro Val Leu Ser Arg 151015 Arg Phe Gly Lys Ser Leu Gly Val Asp Leu Ser Pro Ser LysLys Gln
20 25 30Cys Asn Tyr Asn Cys Ile Tyr Cys Glu Leu Gly Lys Ala Lys Pro Ile
35 40 45Glu Arg Met Glu Glu Val Ile Lys Val Glu Thr Leu Ile Asn Ala Ile
50 55 60Gln Asn Ala Leu Asn Asn Leu Thr Thr Pro Ile Asp Val Leu Thr Ile65 70 75 80Thr Ala Asn Gly Glu Pro Thr Leu Tyr Pro His Leu Leu Glu Leu Ile
85 90 95Gln Ser Ile Lys Pro Phe Leu Lys Gly Val Lys Thr Leu Ile Leu Ser
100 105 110Asn Gly Ser Leu Phe Tyr Glu Pro Lys Val Gln Gln Ala Leu Lys Glu
115 120 125Phe Asp Ile Val Lys Phe Ser Leu Asp Ala Ile Asp Leu Lys Ala Phe
130 135 140Glu Arg Val Asp Lys Pro Tyr Ser Lys Asp Ile Asn Lys Ile Leu Glu145 150 155 160Gly Ile Leu Arg Phe Ser Gln Ile Tyr Gln Gly Gln Leu Val Ala Glu
165 170 175Val Leu Leu Ile Lys Gly Val Asn Asp Ser Ala Asn Asn Leu Lys Leu
180 185 190Ile Ala Ala Phe Leu Lys Gln Ile Asn Ile Ala Arg Val Asp Leu Ser
195 200 205Thr Ile Asp Arg Pro Ser Ser Phe Lys Ala Pro Lys Leu Ser Glu Asp
210 215 220Glu Leu Leu Lys Cys Ser Leu Phe Phe Glu Gly Leu Cys Val Ser Leu225 230 235 240Pro Lys Arg Ser Ile Thr Gln Ala Lys Lys Leu Ile Ser Cys GlyIle
245 250 255Asp Glu Leu Leu Ala Leu Ile Ser Arg Arg Pro Leu Ser Ala Glu Glu
260 265 270Ala Pro Leu Ile Leu Asp Ser Asn Ala Phe Lys His Leu Glu Thr Leu
275 280 285Leu Asn His Lys Gln Ile Thr Ile Lys Lys Val Gly Ser Leu Glu Phe
290 295 300Tyr Cys Ala Phe305
(2) Sequence 629 data: (i) sequence characteristics: length (A): 1350bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1280 (D) other information: (xi) Description of the sequence: sequence 629: ATCAATCTAA CTTGAGTGGA TTTTTCGTAT TAGTTTCCAT GATATAATTT TGAAAAGTAA 60GATTGTTTTT TAAAAAAAGG TTGGTA ATG GAA TCA GTA AAA ACA GGA AAA ACA 113
Met Glu Ser Val Lys Thr Gly Lys Thr
1 5AAT AAG GTT GGC AAG AAT ACA GAG ATG GCT AAT ACA AAG GCA AAT AAA 161Asn Lys Val Gly Lys Asn Thr Glu Met Ala Asn Thr Lys Ala Asn Lys10 15 20 25GAG ACT CAT TTT AAA CAA GTG AGC GCC ATT ACA AAT ATA ATC AGA TCA 209Glu Thr His Phe Lys Gln Val Ser Ala Ile Thr Asn Ile Ile Arg Ser
30 35 40GTT GGT GGG TTT TTT ACA AAA ATT GCA AAG AGA GTT AGA GGA CTT GTA 257Val Gly Gly Phe Phe Thr Lys Ile Ala Lys Arg Val Arg Gly Leu Val
45 50 55AAA AAA CAC CCC AAG AAA AGC AGT GCG GCA TTA GTA GTA TTG ACC CAT 305Lys Lys His Pro Lys Lys Ser Ser Ala Ala Leu Val Val Leu Thr His
60 65 70ATT GCG TGC AAG AAA GCG AAA GAA TTA GAC GAT AAA GTC CAA GAT AAA 353Ile Ala Cys Lys Lys Ala Lys Glu Leu Asp Asp Lys Val Gln Asp Lys
75 80 85TCC AAA CAA GCT GAA AAA GAA AAT CAA ATC AAT TGG TGG AAA TAT TCA 401Ser Lys Gln Ala Glu Lys Glu Asn Gln Ile Asn Trp Trp Lys Tyr Ser90 95 100 105GGA TTA ACA ATA GCG GCA AGT TTA TTA TTA GCC GCT TGT AGC GCT GGT 449Gly Leu Thr Ile Ala Ala Ser Leu Leu Leu Ala Ala Cys Ser Ala Gly
110 115 120GAT ACT GAT AAA CAG ATA GAA CTA GAA CAA GAA AAA AAG GAA GCT GAA 497Asp Thr Asp Lys Gln Ile Glu Leu Glu Gln Glu Lys Lys Glu Ala Glu
125 130 135AAC GCT AGG GAT AGA GCG AAC AAG AGT GGG ATA GAA CTA GAA CAA GAA 545Asn Ala Arg Asp Arg Ala Asn Lys Ser Gly Ile Glu Leu Glu Gln Glu
140 145 150AGA CAG AAA ACA AAC AAG AGT GGG ATA GAA CTC GCT AAT AGT CAA ATA 593Arg Gln Lys Thr Asn Lys Ser Gly Ile Glu Leu Ala Asn Ser Gln Ile
155 160 165AAA GCA GAA CAA GAA AGA CAA AAG ACA GAA CAA GAA AAA CAA AAA GCA 641Lys Ala Glu Gln Glu Arg Gln Lys Thr Glu Gln Glu Lys Gln Lys Ala170 175 180 185AAT AAG AGT GCG ATA GAG TTA GAA CAG CAA AAA CAA AAG ACC ATT AAT 689Asn Lys Ser Ala Ile Glu Leu Glu Gln Gln Lys Gln Lys Thr Ile Asn
190 195 200ACA CAA AGA GAT TTG ATT AAA GAA CAG AAA GAT TTC ATT AAA GAA ACA 737Thr Gln Arg Asp Leu Ile Lys Glu Gln Lys Asp Phe Ile Lys Glu Thr
205 210 215GAA CAAAAT TGC CAA GAA AAT CAT AAT CAA TTC TTT ATT AAA AAA TTA 785Glu Gln Asn Cys Gln Glu Asn His Asn Gln Phe Phe Ile Lys Lys Leu
220 225 230GGA ATT AAG GGT GGC ATT GCT ATA GAA GTA GAA GCT GAA TGC AAA ACC 833Gly Ile Lys Gly Gly Ile Ala Ile Glu Val Glu Ala Glu Cys Lys Thr
235 240 245CCT AAA CCT GCA AAA ACC AAT CAA ACC CCT ATC CAG CCA AAA CAC CTC 881Pro Lys Pro Ala Lys Thr Asn Gln Thr Pro Ile Gln Pro Lys His Leu250 255 260 265CCA AAC TCT AAA CAA CCT CAT TCT CAA AGA GGA TCA AAA GCG CAA GAG 929Pro Asn Ser Lys Gln Pro His Ser Gln Arg Gly Ser Lys Ala Gln Glu
270 275 280TTT ATC GCT TAT TTG CAA AAA GAG CTA GAA TTT CTG CCC TAT TCG CAA 977Phe Ile Ala Tyr Leu Gln Lys Glu Leu Glu Phe Leu Pro Tyr Ser Gln
285 290 295AAA GCT ATC GCT AAA CAA GTG AAT TTC TAT AAA CCA AGT TCT ATC GCT 1025Lys Ala Ile Ala Lys Gln Val Asn Phe Tyr Lys Pro Ser Ser Ile Ala
300 305 310TAT TTA GAA CTA GAT CCT AGA GAT TTT AAG GTT ACA GAA GAA TGG CAA 1073Tyr Leu Glu Leu Asp Pro Arg Asp Phe Lys Val Thr Glu Glu Trp Gln
315 320 325AAA GAA AAT CTA AAA ATA CGC TCT AAA GCT CAA GCT AAA ATG CTT GAA 1121Lys Glu Asn Leu Lys Ile Arg Ser Lys Ala Gln Ala Lys Met Leu Glu330 335 340 345ATG AGG GAT TTA AAA CCA GAC CCA CAA GCC CAC CTT CCA ACC TCT CAA 1169Met Arg Asp Leu Lys Pro Asp Pro Gln Ala His Leu Pro Thr Ser Gln
350 355 360AGC CTT TTG TTC GTT CAA AAA ATA TTT GCT GAT GTT AAT AAA GAA ATA 1217Ser Leu Leu Phe ValGln Lys Ile Phe Ala Asp Val Asn Lys Glu Ile
365 370 375GAA GCA GTT GCT AAT ACT GAA AAG AAA GCA GAA AAA GCG GGT TAT GGT 1265Glu Ala Val Ala Asn Thr Glu Lys Lys Ala Glu Lys Ala Gly Tyr Gly
380 385 390TAT AGT AAA AGG ATG TAGGCATAAG AAAATAAGAA CACCATAAAA TCGTTTTTAG C 1321Tyr Ser Lys Arg Met
395TTCTAGGAGA CATCAGTCAG TTTCTTGCC 1350
(2) Sequence 630 data:
(i) sequence characteristics:
(A) length: 398 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 630: met Glu Ser Val Lys Thr Gly Lys Thr Asn Lys Val Gly Lys Asn Thr 151015 Glu Met Ala Asn Thr Lys Ala Asn Lys Glu Thr His Phe Lys Gln Val
20 25 30Ser Ala Ile Thr Asn Ile Ile Arg Ser Val Gly Gly Phe Phe Thr Lys
35 40 45Ile Ala Lys Arg Val Arg Gly Leu Val Lys Lys His Pro Lys Lys Ser
50 55 60Ser Ala Ala Leu Val Val Leu Thr His Ile Ala Cys Lys Lys Ala Lys65 70 75 80Glu Leu Asp Asp Lys Val Gln Asp Lys Ser Lys Gln Ala Glu Lys Glu
85 90 95Asn Gln Ile Asn Trp Trp Lys Tyr Ser Gly Leu Thr Ile Ala AlaSer
100 105 110Leu Leu Leu Ala Ala Cys Ser Ala Gly Asp Thr Asp Lys Gln Ile Glu
115 120 125Leu Glu Gln Glu Lys Lys Glu Ala Glu Asn Ala Arg Asp Arg Ala Asn
130 135 140Lys Ser Gly Ile Glu Leu Glu Gln Glu Arg Gln Lys Thr Asn Lys Ser145 150 155 160Gly Ile Glu Leu Ala Asn Ser Gln Ile Lys Ala Glu Gln Glu Arg Gln
165 170 175Lys Thr Glu Gln Glu Lys Gln Lys Ala Asn Lys Ser Ala Ile Glu Leu
180 185 190Glu Gln Gln Lys Gln Lys Thr Ile Asn Thr Gln Arg Asp Leu Ile Lys
195 200 205Glu Gln Lys Asp Phe Ile Lys Glu Thr Glu Gln Asn Cys Gln Glu Asn
210 215 220His Asn Gln Phe Phe Ile Lys Lys Leu Gly Ile Lys Gly Gly Ile Ala225 230 235 240Ile Glu Val Glu Ala Glu Cys Lys Thr Pro Lys Pro Ala Lys Thr Asn
245 250 255Gln Thr Pro Ile Gln Pro Lys His Leu Pro Asn Ser Lys Gln Pro His
260 265 270Ser Gln Arg Gly Ser Lys Ala Gln Glu Phe Ile Ala Tyr Leu Gln Lys
275 280 285Glu Leu Glu Phe Leu Pro Tyr Ser Gln Lys Ala Ile Ala Lys Gln Val
290 295 300Asn Phe Tyr Lys Pro Ser Ser Ile Ala Tyr Leu Glu Leu Asp Pro Arg305 310 315 320Asp Phe Lys Val Thr Glu Glu Trp Gln Lys Glu Asn Leu Lys Ile Arg
325 330 335Ser Lys Ala Gln Ala Lys Met Leu Glu Met Arg Asp Leu Lys Pro Asp
340 345 350Pro Gln Ala His Leu Pro Thr Ser Gln Ser Leu Leu Phe Val Gln Lys
355 360 365lle Phe Ala Asp Val Asn Lys Glu Ile Glu Ala Val Ala Asn Thr Glu
370 375 380Lys Lys Ala Glu Lys Ala Gly Tyr Gly Tyr Ser Lys Arg Met385 390 395
(2) Sequence 631 data:
(i) sequence characteristics:
(A) length: 1939bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic RNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1886
(D) Other information:
(xi) Description of the sequence: sequence 631: AAGATTGCTA AATTTTAAGG TTTGAAGAAA GGAAACATAA GTTTTAAAGA ATG AGT 56
Met Ser
1GCG GAA CTG ATT GCT GTT TAT AAA GAC GAG CAA ATA ATA GAT TTA GAG 104Ala Glu Leu Ile Ala Val Tyr Lys Asp Glu Gln Ile Ile Asp Leu Glu
5 10 15AGC GCG AAA GTC TTA GGG CTG AGC GAT GGG ATT AAA GCG TTA AAC GGG 152Ser Ala Lys Val Leu Gly Leu Ser Asp Gly Ile Lys Ala Leu Asn Gly
20 25 30ACA GAG CCG ATA TAT TTT GAT GAT TCG CCT TTG GCT TTA GAG GTG ATT 200Thr Glu Pro Ile Tyr Phe Asp Asp Ser Pro Leu Ala Leu Glu Val Ile35 40 45 50AGG CAT TCA TGC GCG CAT TTG CTT GCG CAA AGC TTG AAA GCC CTT TAT 248Arg His Ser Cys Ala His Leu Leu Ala Gln Ser Leu Lys Ala Leu Tyr
55 60 65CCG GAC GCG AAA TTT TTT GTA GGC CCT GTG GTA GAA GAG GGG TTT TAT 296Pro Asp Ala Lys Phe Phe Val Gly Pro Val Val Glu Glu Gly Phe Tyr
70 75 80TAC GAT TTC AAG ACT TCT TCA AAA ATC AGC GAA GAG GAT TTG CCT AAA 344Tyr Asp Phe Lys Thr Ser Ser Lys Ile Ser Glu Glu Asp Leu Pro Lys
85 90 95ATT GAA GCG AAA ATG AAA GAG TTT GCG AAG TTG AAA CTC GCT ATC ACT 392Ile Glu Ala Lys Met Lys Glu Phe Ala Lys Leu Lys Leu Ala Ile Thr
100 105 110AAA GAG ACT TTA ACC AGA GAG CAA GCT TTG GAG CGT TTT AAG GGC GAT 440Lys Glu Thr Leu Thr Arg Glu Gln Ala Leu Glu Arg Phe Lys Gly Asp115 120 125 130GAA TTA AAG CAT GCG GTG ATG AGT AAA ATC GGT GGC GAT GCC TTT GGC 488Glu Leu Lys His Ala Val Met Ser Lys Ile Gly Gly Asp Ala Phe Gly
135 140 145GTG TAT CAA CAA GGC GAG TTT GAA GAT TTG TGT AAG GGG CCG CAT CTC 536Val Tyr Gln Gln Gly Glu Phe Glu Asp Leu Cys Lys Gly Pro His Leu
150 155 160CCA AAC ACC CGT TTT TTA AAC CAT TTT AAG CTC ACT AAA CTG GCT GGG 584Pro Asn Thr Arg Phe Leu Asn His Phe Lys Leu Thr Lys Leu Ala Gly
165 170 175GCTTAT TTG GGC GGC GAT GAA AAC AAT GAA ATG CTC ATT AGA ATC TAT 632Ala Tyr Leu Gly Gly Asp Glu Asn Asn Glu Met Leu Ile Arg Ile Tyr
180 185 190GGA ATC GCT TTT GCC ACC AAA GAG GGT TTA AAA GAC TAT CTT TTC CAA 680Gly Ile Ala Phe Ala Thr Lys Glu Gly Leu Lys Asp Tyr Leu Phe Gln195 200 205 210ATA GAA GAA GCG AAA AAA CGA GAT CAC AGA AAG CTA GGC GTG GAG CTA 728Ile Glu Glu Ala Lys Lys Arg Asp His Arg Lys Leu Gly Val Glu Leu
215 220 225GGG CTT TTT AGC TTT GAT GAT GAG ATA GGG GCG GGC TTA CCT TTA TGG 776Gly Leu Phe Ser Phe Asp Asp Glu Ile Gly Ala Gly Leu Pro Leu Trp
230 235 240CTG CCT AAA GGG GCA AGG CTT AGG AAG CGC ATT GAA GAT TTA TTG AGT 824Leu Pro Lys Gly Ala Arg Leu Arg Lys Arg Ile Glu Asp Leu Leu Ser
245 250 255CAA GCG TTA CTT TTA AGA GGC TAT GAG CCG GTT AAA GGT CCT GAG ATT 872Gln Ala Leu Leu Leu Arg Gly Tyr Glu Pro Val Lys Gly Pro Glu Ile
260 265 270TTA AAG AGC GAT GTG TGG AAA ATC AGC GGG CAT TAT GAC AAC TAT AAA 920Leu Lys Ser Asp Val Trp Lys Ile Ser Gly His Tyr Asp Asn Tyr Lys275 280 285 290GAA AAC ATG TAT TTC ACC ACG ATT GAT GAG CAA GAA TAT GGC ATA AAG 968Glu Asn Met Tyr Phe Thr Thr Ile Asp Glu Gln Glu Tyr Gly Ile Lys
295 300 305CCT ATG AAC TGC GTG GGG CAT ATT AAA GTC TAT CAA AGC GCT TTG CAC 1016Pro Met Asn Cys Val Gly His Ile Lys Val Tyr Gln Ser Ala Leu His
310 315 320AGC TAC AGA GAT TTG CCC TTA AGG TTT TAT GAA TAC GGC GTG GTG CAT 1064Ser Tyr Arg Asp Leu Pro Leu Arg Phe Tyr Glu Tyr Gly Val Val His
325 330 335CGG CAT GAA AAA AGC GGC GTG TTG CAT GGG CTT TTA AGG GTT AGG GAA 1112Arg His Glu Lys Ser Gly Val Leu His Gly Leu Leu Arg Val Arg Glu
340 345 350TTT ACC CAA GAT GAT GCA CAT ATT TTT TGC TCT TTT GAA CAG ATC CAA 1160Phe Thr Gln Asp Asp Ala His Ile Phe Cys Ser Phe Glu Gln Ile Gln355 360 365 370AGC GAA GTG AGC GCG ATT TTA GAT TTT ACG CAC AAA ATC ATG CAA GCG 1208Ser Glu Val Ser Ala Ile Leu Asp Phe Thr His Lys Ile Met Gln Ala
375 380 385TTT GAT TTT AGC TAT GAA ATG GAA TTA TCC ACA AGG CCG GCT AAA TCC 1256Phe Asp Phe Ser Tyr Glu Met Glu Leu Ser Thr Arg Pro Ala Lys Ser
390 395 400ATA GGC GAT GAT AAA GTT TGG GAA AAG GCC ACT AAC GCT TTA AAA GAA 1304Ile Gly Asp Asp Lys Val Trp Glu Lys Ala Thr Asn Ala Leu Lys Glu
405 410 415GCC TTA AAA GAA CAC CGC ATT GAT TAC AAG ATT GAT GAA GGG GGA GGG 1352Ala Leu Lys Glu His Arg lle Asp Tyr Lys Ile Asp Glu Gly Gly Gly
420 425 430GCT TTC TAT GGG CCT AAG ATT GAC ATT AAA ATC ACT GAC GCT TTA AAG 1400Ala Phe Tyr Gly Pro Lys Ile Asp Ile Lys Ile Thr Asp Ala Leu Lys435 440 445 450CGT AAA TGG CAG TGT GGC ACG ATT CAA GTG GAT ATG AAT TTG CCT GAA 1448Arg Lys Trp Gln Cys Gly Thr Ile Gln Val Asp Met Asn Leu Pro Glu
455 460 465CGC TTC AAG CTC GCT TTC ACT AAT GAG TAT AAT CAC GCT GAG CAG CCG 1496Arg Phe Lys Leu Ala Phe Thr Asn Glu Tyr Asn His Ala Glu Gln Pro
470 475 480GTG ATG ATC CAC AGA GCG ATT TTA GGC TCG TTT GAA AGG TTT ATT GCG 1544Val Met Ile His Arg Ala Ile Leu Gly Ser Phe Glu Arg Phe Ile Ala
485 490 495ATT TTG AGC GAA CAT TTT GGG GGG AAT TTC CCT TTC TTT GTC GCG CCC 1592Ile Leu Ser Glu His Phe Gly Gly Asn Phe Pro Phe Phe Val Ala Pro
500 505 510ACT CAA ATC GCT CTC ATC CCT ATT AAT GAA GAG CAT CAT GTT TTT GCT 1640Thr Gln Ile Ala Leu Ile Pro Ile Asn Glu Glu His His Val Phe Ala515 520 525 530TTG AAA TTA AAA GAG GCG CTA AAA AAG CGC GAT ATT TTT GTA GAA GTG 1688Leu Lys Leu Lys Glu Ala Leu Lys Lys Arg Asp Ile Phe Val Glu Val
535 540 545TTA GAT AAA AAC GAC AGC TTG AAT AAA AAG GTG CGA TTA GCC GAA AAG 1736Leu Asp Lys Asn Asp Ser Leu Asn Lys Lys Val Arg Leu Ala Glu Lys
550 555 560CAA AAA ATC CCT ATG ATT TTA GTG TTA GGG AAT GAA GAA GTG GAG ACC 1784Gln Lys Ile Pro Met Ile Leu Val Leu Gly Asn Glu Glu Val Glu Thr
565 570 575GAA ATT TTA TCC ATT AGA GAC AGA GAA AAA CAA GAT CAA TAT AAA ATG 1832Glu Ile Leu Ser Ile Arg Asp Arg Glu Lys Gln Asp Gln Tyr Lys Met
580 585 590CCC TTA AAG GAG TTT TTA AAC ATG GTT GAA TCT AAG ATG CAA GAG GTT 1880Pro Leu Lys Glu Phe Leu Asn Met Val Glu Ser Lys Met Gln Glu Val595 600 605 610AGT TTT TGAGTAGAAA CGAAGTGTTG TTAAACGGAG ACATTAATTT TAAAGAAGTG CG 1938Ser PheT 1939
(2) Sequence 632 data:
(i) sequence characteristics:
(A) length: 612 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 632: met Ser Ala Glu Leu Ile Ala Val Tyr Lys Asp Glu Gln Ile Ile Asp 151015 Leu Glu Ser Ala Lys Val Leu Gly Leu Ser Asp Gly Ile Lys Ala Leu
20 25 30Asn Gly Thr Glu Pro Ile Tyr Phe Asp Asp Ser Pro Leu Ala Leu Glu
35 40 45Val Ile Arg His Ser Cys Ala His Leu Leu Ala Gln Ser Leu Lys Ala
50 55 60Leu Tyr Pro Asp Ala Lys Phe Phe Val Gly Pro Val Val Glu Glu Gly65 70 75 80Phe Tyr Tyr Asp Phe Lys Thr Ser Ser Lys Ile Ser Glu Glu Asp Leu
85 90 95Pro Lys Ile Glu Ala Lys Met Lys Glu Phe Ala Lys Leu Lys Leu Ala
100 105 110Ile Thr Lys Glu Thr Leu Thr Arg Glu Gln Ala Leu Glu Arg Phe Lys
115 120 125Gly Asp Glu Leu Lys His Ala Val Met Ser Lys Ile Gly Gly Asp Ala
130 135 140Phe Gly Val Tyr Gln Gln Gly Glu Phe Glu Asp Leu Cys Lys Gly Pro145 150 155 160His Leu Pro Asn Thr Arg Phe Leu Asn His Phe Lys Leu Thr Lys Leu
165 170 175Ala Gly Ala Tyr Leu Gly Gly Asp Glu Asn Asn Glu Met Leu Ile Arg
180 185 190Ile Tyr Gly Ile Ala Phe Ala Thr Lys Glu Gly Leu Lys Asp Tyr Leu
195 200 205Phe Gln Ile Glu Glu Ala Lys Lys Arg Asp His Arg Lys Leu Gly Val
210 215 220Glu Leu Gly Leu Phe Ser Phe Asp Asp Glu Ile Gly Ala Gly Leu Pro225 230 235 240Leu Trp Leu Pro Lys Gly Ala Arg Leu Arg Lys Arg Ile Glu Asp Leu
245 250 255Leu Ser Gln Ala Leu Leu Leu Arg Gly Tyr Glu Pro Val Lys Gly Pro
260 265 270Glu Ile Leu Lys Ser Asp Val Trp Lys Ile Ser Gly His Tyr Asp Asn
275 280 285Tyr Lys Glu Asn Met Tyr Phe Thr Thr Ile Asp Glu Gln Glu Tyr Gly
290 295 300Ile Lys Pro Met Asn Cys Val Gly His Ile Lys Val Tyr Gln Ser Ala305 310 315 320Leu His Ser Tyr Arg Asp Leu Pro Leu Arg Phe Tyr Glu Tyr Gly Val
325 330 335Val His Arg His Glu Lys Ser Gly Val Leu His Gly Leu Leu Arg Val
340 345 350Arg Glu Phe Thr Gln Asp Asp Ala His Ile Phe Cys Ser Phe Glu Gln
355 360 365Ile Gln Ser Glu Val Ser Ala Ile Leu Asp Phe Thr His Lys Ile Met
370 375 380Gln Ala Phe Asp Phe Ser Tyr Glu Met Glu Leu Ser Thr Arg Pro Ala385 390 395 400Lys Ser Ile Gly Asp Asp Lys Val Trp Glu Lys Ala Thr Asn Ala Leu
405 410 415Lys Glu Ala Leu Lys Glu His Arg Ile Asp Tyr Lys Ile Asp Glu Gly
420 425 430Gly Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Lys Ile Thr Asp Ala
435 440 445Leu Lys Arg Lys Trp Gln Cys Gly Thr Ile Gln Val Asp Met Asn Leu
450 455 460Pro Glu Arg Phe Lys Leu Ala Phe Thr Asn Glu Tyr Asn His Ala Glu465 470 475 480Gln Pro Val Met Ile His Arg Ala Ile Leu Gly Ser Phe Glu Arg Phe
485 490 495Ile Ala Ile Leu Ser Glu His Phe Gly Gly Asn Phe Pro Phe Phe Val
500 505 510Ala Pro Thr Gln Ile Ala Leu Ile Pro Ile Asn Glu Glu His His Val
515 520 525Phe Ala Leu Lys Leu Lys Glu Ala Leu Lys Lys Arg Asp Ile Phe Val
530 535 540Glu Val Leu Asp Lys Asn Asp Ser Leu Asn Lys Lys Val Arg Leu Ala545 550 555 560Glu Lys Gln Lys Ile Pro Met Ile Leu Val Leu Gly Asn Glu Glu Val
565 570 575Glu Thr Glu Ile Leu Ser Ile Arg Asp Arg Glu Lys Gln Asp Gln Tyr
580 585 590Lys Met Pro Leu Lys Glu Phe Leu Asn Met Val Glu Ser Lys Met Gln
595 600 605Glu Val Ser Phe
610
(2) Sequence 633 data:
(i) sequence characteristics:
(A) length: 1198bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51 … 1145
(D) Other information:
(xi) Description of the sequence: sequence 633: GCGATTGTGC GGAGTCGTTT TCTCAATTTA GCGCCAATCG GATTAGAGAC ATG TTT 56
Met Phe
1AAA GTA ATG ATG CAA ATG GCG ATC GTT CTC ACT TTT GCT GGC TCT ATA 104Lys Val Met Met Gln Met Ala Ile Val Leu Thr Phe Ala Gly Ser Ile
5 10 15CCG ATC GTG AAA GTG GGG CGC ATT GCC GGG CAA TTT GCC AAG CCT CGC 152Pro Ile Val Lys Val Gly Arg Ile Ala Gly Gln Phe Ala Lys Pro Arg
20 25 30TCC AAT GCG ACT GAA ATG CTG GAT AAT GAA GAA GTG TTG AGT TAC AGA 200Ser Asn Ala Thr Glu Met Leu Asp Asn Glu Glu Val Leu Ser Tyr Arg35 40 45 50GGG GAT ATT ATC AAT GGG ATT TCC AAA AAA GAA AGA GAG CCA AAT CCT 248Gly Asp Ile Ile Asn Gly Ile Ser Lys Lys Glu Arg Glu Pro Asn Pro
55 60 65GAA AGA ATG CTT AAG GCC TAC CAT CAA AGC GTA GCG ACT TTA AAC CTT 296Glu Arg Met Leu Lys Ala Tyr His Gln Ser Val Ala Thr Leu Asn Leu
7075 80ATC AGA GCC TTT GCT CAA GGC GGG TTA GCG GAT TTG GAG CAA GTG CAT 344Ile Arg Ala Phe Ala Gln Gly Gly Leu Ala Asp Leu Glu Gln Val His
85 90 95CGT TTC AAT TTG GAT TTT GTC AAA AAC AAC GAC TTT GGG CAA AAA TAC 392Arg Phe Asn Leu Asp Phe Val Lys Asn Asn Asp Phe Gly Gln Lys Tyr
100 105 110CAG CAA ATC GCT GAC CGG ATC ACG CAA GCT TTA GGG TTT ATG CGA GCA 440Gln Gln Ile Ala Asp Arg Ile Thr Gln Ala Leu Gly Phe Met Arg Ala115 120 125 130TGC GGG GTG GAG ATA GAG CGA ACG CCT ATT CTT AGG GAA GTG GAA TTT 488Cys Gly Val Glu Ile Glu Arg Thr Pro Ile Leu Arg Glu Val Glu Phe
135 140 145TAC ACC AGC CAC GAA GCG TTA CTG CTC CAT TAT GAA GAG CCG TTG GTG 536Tyr Thr Ser His Glu Ala Leu Leu Leu His Tyr Glu Glu Pro Leu Val
150 155 160CGT AAG GAT AGT CTG ACT AAC CAG TTT TAT GAT TGC TCC GCG CAC ATG 584Arg Lys Asp Ser Leu Thr Asn Gln Phe Tyr Asp Cys Ser Ala His Met
165 170 175CTA TGG ATT GGC GAA AGG ACA AGA GAC CCT AAG GGT GCG CAT GTG GAG 632Leu Trp Ile Gly Glu Arg Thr Arg Asp Pro Lys Gly Ala His Val Glu
180 185 190TTT TTA AGG GGG GTT TGT AAC CCT ATT GGC GTG AAA ATC GGG CCT AAT 680Phe Leu Arg Gly Val Cys Asn Pro Ile Gly Val Lys Ile Gly Pro Asn195 200 205 210GCG AGC GTG AGC GAA GTG TTA GAA TTG TGC GAT GTT TTA AAC CCG CGC 728Ala Ser Val Ser Glu Val Leu Glu Leu Cys Asp Val Leu Asn Pro Arg
215 220 225AAC ATT AAG GGG CGT TTG AAT TTG ATC GTG CGC ATG GGT TCT AAG ATG 776Asn Ile Lys Gly Arg Leu Asn Leu Ile Val Arg Met Gly Ser Lys Met
230 235 240ATT AAA GAG CGT TTG CCT AAA CTT TTA CAA GGG GTG TTG GAA GAA AAA 824Ile Lys Glu Arg Leu Pro Lys Leu Leu Gln Gly Val Leu Glu Glu Lys
245 250 255CGC CAT ATT TTA TGG AGC ATT GAT CCC ATG CAT GGC AAC ACG GTT AAA 872Arg His Ile Leu Trp Ser Ile Asp Pro Met His Gly Asn Thr Val Lys
260 265 270ACC AGC TTG GGG GTT AAA ACA AGG GCT TTT GAT AGC GTG TTA GAT GAA 920Thr Ser Leu Gly Val Lys Thr Arg Ala Phe Asp Ser Val Leu Asp Glu275 280 285 290GTG AAA AGC TTT TTT GAA ATC CAT AGG GCT GAA GGG AGT TTG GCT TCA 968Val Lys Ser Phe Phe Glu Ile His Arg Ala Glu Gly Ser Leu Ala Ser
295 300 305GGG GTT CAT TTG GAA ATG ACA GGT GAG AAT GTT ACA GAA TGT ATC GGT 1016Gly Val His Leu Glu Met Thr Gly Glu Asn Val Thr Glu Cys Ile Gly
310 315 320GGC TCG CAA GCG ATC ACC GAA GAG GGT TTG AGC TGC CAT TAC TAC ACG 1064Gly Ser Gln Ala Ile Thr Glu Glu Gly Leu Ser Cys His Tyr Tyr Thr
325 330 335CAA TGC GAT CCA AGA TTA AAC GCC ACC CAA GCC CTA GAA CTC GCC TTC 1112Gln Cys Asp Pro Arg Leu Asn Ala Thr Gln Ala Leu Glu Leu Ala Phe
340 345 350TTA ATC GCT GAC ATG CTC AAA AAA CAG CAC GCT TAGTTAAAAA GAGATTAATC 1165Leu Ile Ala Asp Met Leu Lys Lys Gln His Ala355 360 365TTTTTTTAAC TCTTTTACTT TATAATTATC GTT 1198
(2) Sequence 634 data: (i) sequence characteristics: length (A): 365 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 634: met Phe Lys Val Met Met Gln Met Ala Ile Val Leu Thr Phe Ala Gly 151015 Ser Ile Pro Ile Val Lys Val Gly Arg Ile Ala Gly Gln Phe Ala Lys
20 25 30Pro Arg Ser Asn Ala Thr Glu Met Leu Asp Asn Glu Glu Val Leu Ser
35 40 45Tyr Arg Gly Asp Ile Ile Asn Gly Ile Ser Lys Lys Glu Arg Glu Pro
50 55 60Asn Pro Glu Arg Met Leu Lys Ala Tyr His Gln Ser Val Ala Thr Leu65 70 75 80Asn Leu Ile Arg Ala Phe Ala Gln Gly Gly Leu Ala Asp Leu Glu Gln
85 90 95Val His Arg Phe Asn Leu Asp Phe Val Lys Asn Asn Asp Phe Gly Gln
100 105 110Lys Tyr Gln Gln Ile Ala Asp Arg Ile Thr Gln Ala Leu Gly Phe Met
115 120 125Arg Ala Cys Gly Val Glu Ile Glu Arg Thr Pro Ile Leu Arg Glu Val
130 135 140Glu Phe Tyr Thr Ser His Glu Ala Leu Leu Leu His Tyr Glu Glu Pro145 150 155 160Leu Val Arg Lys Asp Ser Leu Thr Asn Gln Phe Tyr Asp Cys Ser Ala
165 170 175His Met Leu Trp Ile Gly Glu Arg Thr Arg Asp Pro Lys Gly Ala His
180 185 190Val Glu Phe Leu Arg Gly Val Cys Asn Pro Ile Gly Val Lys Ile Gly
195 200 205Pro Asn Ala Ser Val Ser Glu Val Leu Glu Leu Cys Asp Val Leu Asn
210 215 220Pro Arg Asn Ile Lys Gly Arg Leu Asn Leu Ile Val Arg Met Gly Ser225 230 235 240Lys Met Ile Lys Glu Arg Leu Pro Lys Leu Leu Gln Gly Val Leu Glu
245 250 255Glu Lys Arg His Ile Leu Trp Ser Ile Asp Pro Met His Gly Asn Thr
260 265 270Val Lys Thr Ser Leu Gly Val Lys Thr Arg Ala Phe Asp Ser Val Leu
275 280 285Asp Glu Val Lys Ser Phe Phe Glu Ile His Arg Ala Glu Gly Ser Leu
290 295 300Ala Ser Gly Val His Leu Glu Met Thr Gly Glu Asn Val Thr Glu Cys305 310 315 320Ile Gly Gly Ser Gln Ala Ile Thr Glu Glu Gly Leu Ser Cys His Tyr
325 330 335Tyr Thr Gln Cys Asp Pro Arg Leu Asn Ala Thr Gln Ala Leu Glu Leu
340 345 350Ala Phe Leu Ile Ala Asp Met Leu Lys Lys Gln His Ala
355 360 365
(2) Sequence 635 data: (i) sequence characteristics: length (A): 388bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 335 (D) other information: (xi) Description of the sequence: sequence 635: TGATAGCGAC TTTTTGAGGC CCATGCACCC CAAAAACGGT TTTTAATTCA ATG TCA 56
Met Ser
1GCT GTC CGG CTA GGCCCG CCA ATA AGG AGC ATG TTT GTG GGT AAT GCA 104Ala Val Arg Leu Gly Pro Pro Ile Arg Ser Met Phe Val Gly Asn Ala
5 10 15CCG TTT TGG CTT TGG TTT TTT AAA GCT TGC ATG CCT TCA CTC AAA TTG 152Pro Phe Trp Leu Trp Phe Phe Lys Ala Cys Met Pro Ser Leu Lys Leu
20 25 30CGC ACA ATG GAT TCT TTT TTC AAT AAG ATG ATG CAA TTA AGG GTG ATG 200Arg Thr Met Asp Ser Phe Phe Asn Lys Met Met Gln Leu Arg Val Met35 40 45 50AGC GAA AGC AAT CGC GGG CTT GCA TGC GAA GAG ACC GCC CCA ATC ATG 248Ser Glu Ser Asn Arg Gly Leu Ala Cys Glu Glu Thr Ala Pro Ile Met
55 60 65CCC AAG CTT GAA ATC CCA CAA ACC CCA TGC AAT AAA GCC GTA TCA ATC 296Pro Lys Leu Glu Ile Pro Gln Thr Pro Cys Asn Lys Ala Val Ser Ile
70 75 80TCA AAC AAC TCT TCA CGC ATC GCT TCA ATT TCT TTA TCA TAAGGCTGTA AA 347Ser Asn Asn Ser Ser Arg Ile Ala Ser Ile Ser Leu Ser
85 90 95GTAAAATCCT TAAACGCTTC AAAATTCAAA TTCAAATCTG T 388
(2) Sequence 636 data: (i) sequence characteristics: length (A): 95 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 636: met Ser Ala Val Arg Leu Gly Pro Pro Ile Arg Ser Met Phe Val Gly 151015 Asn Ala Pro Phe Trp Leu Trp Phe Phe Lys Ala Cys Met Pro Ser Leu
20 25 30Lys Leu Arg Thr Met Asp Ser Phe Phe Asn Lys Met Met Gln Leu Arg
35 40 45Val Met Ser Glu Ser Asn Arg Gly Leu Ala Cys Glu Glu Thr Ala Pro
50 55 60Ile Met Pro Lys Leu Glu Ile Pro Gln Thr Pro Cys Asn Lys Ala Val65 70 75 80Ser Ile Ser Asn Asn Ser Ser Arg Ile Ala Ser Ile Ser Leu Ser
859095 (2) sequence 637 data: (i) sequence characteristics: length (A): 1756bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1703 (D) other information: (xi) Description of the sequence: sequence 637: TTTTAAAGAG AACTAGCACT AAGAGAATAT TTTTAAAAAG GGATTTTTTA GTG CTA 56
Val Leu
1GAA TTT CAT CAA ATT TAT GAT CCT TTG GGT AAT ATT TGG CTG AGC GCT 104Glu Phe His Gln Ile Tyr Asp Pro Leu Gly Asn Ile Trp Leu Ser Ala
5 10 15CTT GTG GCC TTA TTG CCG ATT TTA TTG TTT TTC TTA TCT TTA ATG GTT 152Leu Val Ala Leu Leu Pro Ile Leu Leu Phe Phe Leu Ser Leu Met Val
20 25 30TTT AAA CTC AAA GGT TAT ACA GCG GCC TTT TTG AGC GTG GCC TTA TCA 200Phe Lys Leu Lys Gly Tyr Thr Ala Ala Phe Leu Ser Val Ala Leu Ser35 40 45 50GCC GTT ATT GCG GTT TTA GTG TAT AAA ATG CCT GTT AGC ATG GTG GGT 248Ala Val Ile Ala Val Leu Val Tyr Lys Met Pro Val Ser Met Val Gly
55 60 65TCA AGC TTC CTT TAC GGC TTT CTT TAT GGC TTA TGG CCG ATC GCT TGG 296Ser Ser Phe Leu Tyr Gly Phe Leu Tyr Gly Leu Trp Pro Ile Ala Trp
70 75 80ATC ATT ATT GCG GCG ATT TTT TTA TACAAA CTC AGC GTT AAA TCC GGC 344Ile Ile Ile Ala Ala Ile Phe Leu Tyr Lys Leu Ser Val Lys Ser Gly
85 90 95TAT TTT GAA ATT TTA AAA GAA AGC GTC CAG TCC ATC ACT TTA GAT CAC 392Tyr Phe Glu Ile Leu Lys Glu Ser Val Gln Ser Ile Thr Leu Asp His
100 105 110CGC ATT TTA GTG ATT TTG ATT GGC TTT TGT TTT GGC TCG TTT TTA GAA 440Arg Ile Leu Val Ile Leu Ile Gly Phe Cys Phe Gly Ser Phe Leu Glu115 120 125 130GGG GCG ATC GGC TTT GGA GGG CCT ATT GCC ATT ACC GCA GCG ATT TTA 488Gly Ala Ile Gly Phe Gly Gly Pro Ile Ala Ile Thr Ala Ala Ile Leu
135 140 145GTG GGC TTA GGG TTA AGC CCT TTG TAT TCT GCC GGG TTA TGT TTG ATC 536Val Gly Leu Gly Leu Ser Pro Leu Tyr Ser Ala Gly Leu Cys Leu Ile
150 155 160GCT AAT ACC GCT CCT GTA GCT TTT GGC GCG GTG GGT ATC CCT ATA AGT 584Ala Asn Thr Ala Pro Val Ala Phe Gly Ala Val Gly Ile Pro Ile Ser
165 170 175GCT ATG GCG AGC GCG GTA GGG GTG CCA GCG ATT TTA ATT TCA GCC ATG 632Ala Met Ala Ser Ala Val Gly Val Pro Ala Ile Leu Ile Ser Ala Met
180 185 190ACG GGT AAA ATC CTC TTT TTT GTG AGC TTG TTA GTG CCG TTT TTC ATT 680Thr Gly Lys Ile Leu Phe Phe Val Ser Leu Leu Val Pro Phe Phe Ile195 200 205 210GTG TTT TTA ATG GAT GGC TTT AAA GGG ATT AAA GAA ACT TTT CCG GCC 728Val Phe Leu Met Asp Gly Phe Lys Gly Ile Lys Glu Thr Phe Pro Ala
215 220 225GTT TTT ATC GCG GCT TTT TCT TTC GCT GGT GCG CAA TTT TTA AGC TCT 776Val Phe Ile Ala Ala Phe Ser Phe Ala Gly Ala Gln Phe Leu Ser Ser
230 235 240AAT TAT TTA GGG CCA GAA TTG CCT GGT ATT ATT TCA GCC CTT GTT TCA 824Asn Tyr Leu Gly Pro Glu Leu Pro Gly Ile Ile Ser Ala Leu Val Ser
245 250 255CTC GTT GCA ACA GCG CTC TTT TTG AAA TTT TGG CAG CCT AAA GCG ATT 872Leu Val Ala Thr Ala Leu Phe Leu Lys Phe Trp Gln Pro Lys Ala lle
260 265 270TTT AGA AGC GAC GGC AAA GCG GCT TCG TTC ACT AAG AGT AAC CAT CAT 920Phe Arg Ser Asp Gly Lys Ala Ala Ser Phe Thr Lys Ser Asn His His275 280 285 290ATT TGT AAG ATC TAT GTC GCT TGG TCT CCT TTT GTG ATT TTA GTT TTA 968Ile Cys Lys Ile Tyr Val Ala Trp Ser Pro Phe Val Ile Leu Val Leu
295 300 305GTG ATT GTG CTA TGG ATA CAG CCT TTT TTT AAA GCC TTG TTT GAA AAA 1016Val Ile Val Leu Trp Ile Gln Pro Phe Phe Lys Ala Leu Phe Glu Lys
310 315 320GAC GGC TTG TTA GCT TTT TCT AAT TTT TAT TTT GAA TTC AAT AAC ATC 1064Asp Gly Leu Leu Ala Phe Ser Asn Phe Tyr Phe Glu Phe Asn Asn Ile
325 330 335AGT AAC CAC ATC TTT AAA AGC CCG CCT TTT GTA GAA GCC AAT CAA AGC 1112Ser Asn His Ile Phe Lys Ser Pro Pro Phe Val Glu Ala Asn Gln Ser
340 345 350GTG AGT TTT CCG GTG GTG TTT AAA TTT CTC TTA ATC AAC ACG GTT GGC 1160Val Ser Phe Pro Val Val Phe Lys Phe Leu Leu Ile Asn Thr Val Gly355 360 365 370ACT TCC ATT TTT TTA GCC GCT CTT GTT AGC ATG CTC GTT TTA AGG GTG 1208Thr Ser Ile Phe Leu Ala Ala Leu Val Ser Met Leu Val Leu Arg Val
375380 385CGA GTG AGC GAT GCG CTG AGC GTC TTT GGC GAG ACT TTA AAA GAA ATG 1256Arg Val Ser Asp Ala Leu Ser Val Phe Gly Glu Thr Leu Lys Glu Met
390 395 400CGT TAC CCC ATT CTC ACC ATT GGT TTA GTC TTA AGC TTT GCC TAT GTG 1304Arg Tyr Pro Ile Leu Thr Ile Gly Leu Val Leu Ser Phe Ala Tyr Val
405 410 415TCT AAT TAC AGC GGG ATT TCT TCC ACT CTA GCC TTA GCG CTC ACG CAT 1352Ser Asn Tyr Ser Gly Ile Ser Ser Thr Leu Ala Leu Ala Leu Thr His
420 425 430ACG GGT TTG GCT TTC ACC TTT TTC TCG CCC TTG ATC GGG TGG GTA GGC 1400Thr Gly Leu Ala Phe Thr Phe Phe Ser Pro Leu Ile Gly Trp Val Gly435 440 445 450GTG TTT TTA ACC GGG AGC GAT ACG AGT TCC AAT CTT TTG TTT GGC TCT 1448Val Phe Leu Thr Gly Ser Asp Thr Ser Ser Asn Leu Leu Phe Gly Ser
455 460 465TTA CAG CAA CTC ACC GCC CAA CGA TTG CAC CTC CCT GAG GTT TTA ACC 1496Leu Gln Gln Leu Thr Ala Gln Arg Leu His Leu Pro Glu Val Leu Thr
470 475 480CTA ACG GCT AAT ACC GTG GGT GGC ACT TTA GGC AAG ATG ATA AGC CCT 1544Leu Thr Ala Asn Thr Val Gly Gly Thr Leu Gly Lys Met Ile Ser Pro
485 490 495CAA AGC ATC GCT ATC GCT TGC GCG GCG GTG GGG TTA GCC GGG AAA GAG 1592Gln Ser Ile Ala Ile Ala Cys Ala Ala Val Gly Leu Ala Gly Lys Glu
500 505 510AGC GAT TTG TTC AAA TTC ACG GTT AAA TAC TCC CTT ATT TTT GTA GCG 1640Ser Asp Leu Phe Lys Phe Thr Val Lys Tyr Ser Leu Ile Phe Val Ala515 520 525 530ATC ATG GGA GTT GTG ATC AGC GCG ATT GCG TAT TTG ATC CCT GAA GTG 1688Ile Met Gly Val Val Ile Ser Ala Ile Ala Tyr Leu Ile Pro Glu Val
535 540 545GTG CCT GCG ATA AAG TAGGGCCATT TTAGATTTAG CAGGGTTTAA CCCCCAAATA A 1744Val Pro Ala Ile Lys
550ATTTTTTTGT TT 1756
(2) Sequence 638 data: (i) sequence characteristics: length (A): 551 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 638: val Leu Glu Phe His Gln Ile Tyr Asp Pro Leu Gly Asn Ile Trp Leu 151015 Ser Ala Leu Val Ala Leu Leu Pro Ile Leu Leu Phe Phe Leu Ser Leu
20 25 30Met Val Phe Lys Leu Lys Gly Tyr Thr Ala Ala Phe Leu Ser Val Ala
35 40 45Leu Ser Ala Val Ile Ala Val Leu Val Tyr Lys Met Pro Val Ser Met
50 55 60Val Gly Ser Ser Phe Leu Tyr Gly Phe Leu Tyr Gly Leu Trp Pro Ile65 70 75 80Ala Trp Ile Ile Ile Ala Ala Ile Phe Leu Tyr Lys Leu Ser Val Lys
85 90 95Ser Gly Tyr Phe Glu Ile Leu Lys Glu Ser Val Gln Ser Ile Thr Leu
100 105 110Asp His Arg Ile Leu Val Ile Leu Ile Gly Phe Cys Phe Gly Ser Phe
115 120 125Leu Glu Gly Ala Ile Gly Phe Gly Gly Pro Ile Ala Ile Thr Ala Ala
130 135 140Ile Leu Val Gly Leu Gly Leu Ser Pro Leu Tyr Ser Ala Gly Leu Cys145 150 155160Leu Ile Ala Asn Thr Ala Pro Val Ala Phe Gly Ala Val Gly Ile Pro
165 170 175Ile Ser Ala Met Ala Ser Ala Val Gly Val Pro Ala Ile Leu Ile Ser
180 185 190Ala Met Thr Gly Lys Ile Leu Phe Phe Val Ser Leu Leu Val Pro Phe
195 200 205Phe Ile Val Phe Leu Met Asp Gly Phe Lys Gly Ile Lys Glu Thr Phe
210 215 220Pro Ala Val Phe Ile Ala Ala Phe Ser Phe Ala Gly Ala Gln Phe Leu225 230 235 240Ser Ser Asn Tyr Leu Gly Pro Glu Leu Pro Gly Ile Ile Ser Ala Leu
245 250 255Val Ser Leu Val Ala Thr Ala Leu Phe Leu Lys Phe Trp Gln Pro Lys
260 265 270Ala Ile Phe Arg Ser Asp Gly Lys Ala Ala Ser Phe Thr Lys Ser Asn
275 280 285His His Ile Cys Lys Ile Tyr Val Ala Trp Ser Pro Phe Val Ile Leu
290 295 300Val Leu Val Ile Val Leu Trp Ile Gln Pro Phe Phe Lys Ala Leu Phe305 310 315 320Glu Lys Asp Gly Leu Leu Ala Phe Ser Asn Phe Tyr Phe Glu Phe Asn
325 330 335Asn Ile Ser Asn His Ile Phe Lys Ser Pro Pro Phe Val Glu Ala Asn
340 345 350Gln Ser Val Ser Phe Pro Val Val Phe Lys Phe Leu Leu Ile Asn Thr
355 360 365Val Gly Thr Ser Ile Phe Leu Ala Ala Leu Val Ser Met Leu Val Leu
370 375 380Arg Val Arg Val Ser Asp Ala Leu Ser Val Phe Gly Glu Thr Leu Lys385 390 395 400Glu Met Arg Tyr Pro Ile Leu Thr Ile Gly Leu Val Leu Ser Phe Ala
405 410 415Tyr Val Ser Asn Tyr Ser Gly Ile Ser Ser Thr Leu Ala Leu Ala Leu
420 425 430Thr His Thr Gly Leu Ala Phe Thr Phe Phe Ser Pro Leu Ile Gly Trp
435 440 445Val Gly Val Phe Leu Thr Gly Ser Asp Thr Ser Ser Asn Leu Leu Phe
450 455 460Gly Ser Leu Gln Gln Leu Thr Ala Gln Arg Leu His Leu Pro Glu Val465 470 475 480Leu Thr Leu Thr Ala Asn Thr Val Gly Gly Thr Leu Gly Lys Met Ile
485 490 495Ser Pro Gln Ser Ile Ala Ile Ala Cys Ala Ala Val Gly Leu Ala Gly
500 505 510Lys Glu Ser Asp Leu Phe Lys Phe Thr Val Lys Tyr Ser Leu Ile Phe
515 520 525Val Ala Ile Met Gly Val Val Ile Ser Ala He Ala Tyr Leu Ile Pro
530 535 540Glu Val Val Pro Ala Ile Lys545 550
(2) Sequence 639 data: (i) sequence characteristics: length (A): 961bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 51.. 908 (D) other information: (xi) Description of the sequence: sequence 639: TGAACCACGC CATAAAAAAG TTCATGATAA TGGCATAAAG GAAAGTTGAA ATG GAT 56
Met Asp
1TTT TTA AAC GAC CAT ATA AAT GTT TTT GGC TTG ATT GCA GCG CTT GTG 104Phe Leu Asn Asp His Ile Asn Val Phe Gly Leu Ile Ala Ala Leu Val
5 10 15ATT TTA GTT TTA ACC ATC TAT GAA TCC AGT TCG CTC ATT AAA GAA ATG 152Ile Leu Val Leu Thr Ile Tyr Glu Ser Ser Ser Leu Ile Lys Glu Met
20 25 30CGC GAC AGC AAA TCT CAA GGT GAG CTT GTA GAA AAT GGG CAT TTG ATT 200Arg Asp Ser Lys Ser Gln Gly Glu Leu Val Glu Asn Gly His Leu Ile35 40 45 50GAT GGG ATA GGG GAG TTT GCC AAT AAT GTG CCA GTA GGC TGG ATC GCA 248Asp Gly Ile Gly Glu Phe Ala Asn Asn Val Pro Val Gly Trp Ile Ala
55 60 65AGC TTT ATG TGC ACG ATT GTG TGG GCT TTT TGG TAT TTC TTC TTT GGG 296Ser Phe Met Cys Thr Ile Val Trp Ala Phe Trp Tyr Phe Phe Phe Gly
70 75 80TAT CCG CTG AAT AGC TTT TCT CAA ATC GGG CAA TAC AAT GAA GAG GTT 344Tyr Pro Leu Asn Ser Phe Ser Gln Ile Gly Gln Tyr Asn Glu Glu Val
85 90 95AAA GCG CAC AAC CAA AAA TTT GAG GCC AAG TGG AAG CAT TTG GGT CAA 392Lys Ala His Asn Gln Lys Phe Glu Ala Lys Trp Lys His Leu Gly Gln
100 105 110AAG GAA CTG GTG GAT ATG GGT CAA GGC ATC TTT TTA GTC CAT TGT TCG 440Lys Glu Leu Val Asp Met Gly Gln Gly Ile Phe Leu Val His Cys Ser115 120 125 130CAA TGC CAT GGC ATC ACC GCT GAG GGC TTG CAT GGG AGC GCT CAA AAT 488Gln Cys His Gly Ile Thr Ala Glu Gly Leu His Gly Ser Ala Gln Asn
135140 145CTG GTG CGC TGG GGT AAA GAA GAG GGT ATT ATG GAT ACC ATT AAG CAT 536Leu Val Arg Trp Gly Lys Glu Glu Gly Ile Met Asp Thr Ile Lys His
150 155 160GGC TCT AAG GGC ATG GAT TAT CTC GCT GGG GAA ATG CCC GCT ATG GAA 584Gly Ser Lys Gly Met Asp Tyr Leu Ala Gly Glu Met Pro Ala Met Glu
165 170 175TTG GAC GAA AAA GAC GCT AAA GCG ATC GCA AGC TAT GTG ATG GCA GAA 632Leu Asp Glu Lys Asp Ala Lys Ala Ile Ala Ser Tyr Val Met Ala Glu
180 185 190CTT TCT AGC GTT AAA AAA ACC AAA AAC CCT CAA CTC ATT GAT AAA GGC 680Leu Ser Ser Val Lys Lys Thr Lys Asn Pro Gln Leu Ile Asp Lys Gly195 200 205 210AAG GAA TTG TTT GAA AGC ATG GGT TGC ACA GGC TGT CAT GGC AAT GAT 728Lys Glu Leu Phe Glu Ser Met Gly Cys Thr Gly Cys His Gly Asn Asp
215 220 225GGT AAG GGC TTG CAA GAA AAT CAA GTG TTT GCA GCC GAT TTG ACC GCT 776Gly Lys Gly Leu Gln Glu Asn Gln Val Phe Ala Ala Asp Leu Thr Ala
230 235 240TAC GGC ACA GAG AAT TTT TTG AGA AAT ATC TTA ACG CAT GGC AAA AAG 824Tyr Gly Thr Glu Asn Phe Leu Arg Asn Ile Leu Thr His Gly Lys Lys
245 250 255GGC AAT ATA GGG CAT ATG CCA TCA TTC AAG TAT AAA AAC TTT AGC GAT 872Gly Asn Ile Gly His Met Pro Ser Phe Lys Tyr Lys Asn Phe Ser Asp
260 265 270TTG CAA GTT AAA GCG TTA CTG AAT TTA TCC AAT CGC TAAAACCCTT AGAAGA 924Leu Gln Val Lys Ala Leu Leu Asn Leu Ser Asn Arg275 280 285TTAAAGGAAA AGAGATGAAA TTTTTAAACG GATTAGC 961
(2) Sequence 640 data: (i) sequence characteristics: length (A): 286 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 640: met Asp Phe Leu Asn Asp His Ile Asn Val Phe Gly Leu Ile Ala Ala 151015 Leu Val Ile Leu Val Leu Thr Ile Tyr Glu Ser Ser Ser Leu Ile Lys
20 25 30Glu Met Arg Asp Ser Lys Ser Gln Gly Glu Leu Val Glu Asn Gly His
35 40 45Leu Ile Asp Gly Ile Gly Glu Phe Ala Asn Asn Val Pro Val Gly Trp
50 55 60Ile Ala Ser Phe Met Cys Thr Ile Val Trp Ala Phe Trp Tyr Phe Phe65 70 75 80Phe Gly Tyr Pro Leu Asn Ser Phe Ser Gln Ile Gly Gln Tyr Asn Glu
85 90 95Glu Val Lys Ala His Asn Gln Lys Phe Glu Ala Lys Trp Lys His Leu
100 105 110Gly Gln Lys Glu Leu Val Asp Met Gly Gln Gly Ile Phe Leu Val His
115 120 125Cys Ser Gln Cys His Gly Ile Thr Ala Glu Gly Leu His Gly Ser Ala
130 135 140Gln Asn Leu Val Arg Trp Gly Lys Glu Glu Gly Ile Met Asp Thr Ile145 150 155 160Lys His Gly Ser Lys Gly Met Asp Tyr Leu Ala Gly Glu Met Pro Ala
165 170 175Met Glu Leu Asp Glu Lys Asp Ala Lys Ala Ile Ala Ser Tyr Val Met
180 185 190Ala Glu Leu Ser Ser Val Lys Lys Thr Lys Asn Pro Gln Leu Ile Asp
195 200 205Lys Gly Lys Glu Leu Phe Glu Ser Met Gly Cys Thr Gly Cys His Gly
210 215 220Asn Asp Gly Lys Gly Leu Gln Glu Asn Gln Val Phe Ala Ala Asp Leu225 230 235 240Thr Ala Tyr Gly Thr Glu Asn Phe Leu Arg Asn Ile Leu Thr His Gly
245 250 255Lys Lys Gly Asn Ile Gly His Met Pro Ser Phe Lys Tyr Lys Asn Phe
260 265 270Ser Asp Leu Gln Val Lys Ala Leu Leu Asn Leu Ser Asn Arg
275280285 (2) sequence 641 data: (i) sequence characteristics: length (A): 307bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 254 (D) other information: (xi) Description of the sequence: sequence 641: TACTGAATTT ATCCAATCGC TAAAACCCTT AGAAGATTAA AGGAAAAGAG ATG AAA 56
Met Lys
1TTT TTA AAC GGA TTA GCA GGG AAT TTA CTG ATT GTG GTT ATT TTA TTG 104Phe Leu Asn Gly Leu Ala Gly Asn Leu Leu Ile Val Val Ile Leu Leu
5 10 15TGT GTG GCC GTT TTT TTT ACG CTC AAA GCG ATC CAT ATC CAA AAA GAG 152Cys Val Ala Val Phe Phe Thr Leu Lys Ala Ile His Ile Gln Lys Glu
20 25 30CAA GCC ACC AAT TAT TAC CGC TAT AAG GAT ATT AAC GCT TTA GAG ACA 200Gln Ala Thr Asn Tyr Tyr Arg Tyr Lys Asp Ile Asn Ala Leu Glu Thr35 40 45 50AAA AAC ACC CAA AAC CGG GCT AAC TAT GAA TTA GTC AAT CAA GGG AGT 248Lys Asn Thr Gln Asn Arg Ala Asn Tyr Glu Leu Val Asn Gln Gly Ser
55 60 65AAA AAA TGAAATTCAC GACTTTAGAA AAAATTTTAG CTTTGATGGT AGTAGCGACC AT 306Lys Lys
307
(2) Sequence 642 data:
(i) sequence characteristics:
(A) length: 68 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 642: met Lys Phe Leu Asn Gly Leu Ala Gly Asn Leu Leu Ile Val Val Ile 151015 Leu Leu Cys Val Ala Val Phe Phe Thr Leu Lys Ala Ile His Ile Gln
20 25 30Lys Glu Gln Ala Thr Asn Tyr Tyr Arg Tyr Lys Asp Ile Asn Ala Leu
35 40 45Glu Thr Lys Asn Thr Gln Asn Arg Ala Asn Tyr Glu Leu Val Asn Gln
50 55 60Gly Ser Lys Lys65
(2) Sequence 643 data:
(i) sequence characteristics:
(A) length: 843bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...770
(D) Other information:
(xi) Description of the sequence: sequence 643: TTATTAGCTA TCATGCTAAA GAAGTGGCTA ACTTATTACA AAGGAATTGA ATG GGA 56
Met Gly
1CGA GCG TTT GAA TAC AGA AGA GCG GCT AAA GAA AAA CGA TGG GAT AAG 104Arg Ala Phe Glu Tyr Arg Arg Ala Ala Lys Glu Lys Arg Trp Asp Lys
5 10 15ATG AGT AAG GTT TTC CCA AAG CTC GCT AAA GCG ATC ACT CTA GCG GCA 152Met Ser Lys Val Phe Pro Lys Leu Ala Lys Ala Ile Thr Leu Ala Ala
20 25 30AAA GAT GGC GGG AGC GAA CCG GAC ACG AAC GCC AAA CTA CGA ACA GCG 200Lys Asp Gly Gly Ser Glu Pro Asp Thr Asn Ala Lys Leu Arg Thr Ala35 40 45 50ATT TTA AAC GCT AAA GCG CAA AAC ATG CCT AAA GAC AAT ATT GAC GCA 248Ile Leu Asn Ala Lys Ala Gln Asn Met Pro Lys Asp Asn Ile Asp Ala
55 60 65GCG ATT AAA AGA GCG AGC AGT AAA GAA GGG AAT TTG AGT GAA ATC ACT 296Ala Ile Lys Arg Ala Ser Ser Lys Glu Gly Asn Leu Ser Glu Ile Thr
70 75 80TAT GAA GGT AAG GCG AAT TTT GGC GTG CTA ATC ATC ATG GAA TGC ATG 344Tyr Glu Gly Lys Ala Asn Phe Gly Val Leu Ile Ile Met Glu Cys Met
85 90 95ACT GAT AAC CCC ACC AGA ACC ATT GCC AAC CTT AAA AGC TAT TTC AAT 392Thr Asp Asn Pro Thr Arg Thr Ile Ala Asn Leu Lys Ser Tyr Phe Asn
100 105 110AAA ACG CAAGGG GCA AGC ATC GTG CCT AAT GGC TCT TTA GAG TTT ATG 440Lys Thr Gln Gly Ala Ser Ile Val Pro Asn Gly Ser Leu Glu Phe Met115 120 125 130TTT AAC CGA AAA AGC GTG TTT GAA TGC TTG AAA AAT GAA GTG GAA AAT 488Phe Asn Arg Lys Ser Val Phe Glu Cys Leu Lys Asn Glu Val Glu Asn
135 140 145TTA AAA CTC AGT CTA GAA GAT TTA GAA TTC GCT CTC ATT GAT TAT GGT 536Leu Lys Leu Ser Leu Glu Asp Leu Glu Phe Ala Leu Ile Asp Tyr Gly
150 155 160TTG GAA GAA TTA GAA GAA GTG GAA GAC AAG ATC ATT ATT AGG GGG GAT 584Leu Glu Glu Leu Glu Glu Val Glu Asp Lys Ile Ile Ile Arg Gly Asp
165 170 175TAT AAC AGC TTC AAG CTT TTA AAT GAG GGG TTT GAA AGC TTG AAA TTA 632Tyr Asn Ser Phe Lys Leu Leu Asn Glu Gly Phe Glu Ser Leu Lys Leu
180 185 190CCC ATT TTA AAA GCG AGT TTG CAA CGC ATC GCC ACA ACG CCC ATT GAA 680Pro Ile Leu Lys Ala Ser Leu Gln Arg Ile Ala Thr Thr Pro Ile Glu195 200 205 210TTG AAT GAC GAA CAA ATG GAG CTT ACC GAA AAA TTA CTG GAC AGG ATT 728Leu Asn Asp Glu Gln Met Glu Leu Thr Glu Lys Leu Leu Asp Arg Ile
215 220 225GAA GAC GAT GAT GAT GTG GTC GCG CTT TAT ACC AAT ATT GAG TGAAATGCA 779Glu Asp Asp Asp Asp Val Val Ala Leu Tyr Thr Asn Ile Glu
230 235 240AAAAGACTCA AAGTATTTTT TTAAACCACC CAAGCATTCA TCCCAATAGG GAATGCGTTG 839GAGA 843
(2) Sequence 644 data: (i) sequence characteristics: length (A): 240 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 644: met Gly Arg Ala Phe Glu Tyr Arg Arg Ala Ala Lys Glu Lys Arg Trp 151015 Asp Lys Met Ser Lys Val Phe Pro Lys Leu Ala Lys Ala Ile Thr Leu
20 25 30Ala Ala Lys Asp Gly Gly Ser Glu Pro Asp Thr Asn Ala Lys Leu Arg
35 40 45Thr Ala Ile Leu Asn Ala Lys Ala Gln Asn Met Pro Lys Asp Asn Ile
50 55 60Asp Ala Ala lle Lys Arg Ala Ser Ser Lys Glu Gly Asn Leu Ser Glu65 70 75 80Ile Thr Tyr Glu Gly Lys Ala Asn Phe Gly Val Leu Ile Ile Met Glu
85 90 95Cys Met Thr Asp Asn Pro Thr Arg Thr Ile Ala Asn Leu Lys Ser Tyr
100 105 110Phe Asn Lys Thr Gln Gly Ala Ser Ile Val Pro Asn Gly Ser Leu Glu
115 120 125Phe Met Phe Asn Arg Lys Ser Val Phe Glu Cys Leu Lys Asn Glu Val
130 135 140Glu Asn Leu Lys Leu Ser Leu Glu Asp Leu Glu Phe Ala Leu Ile Asp145 150 155 160Tyr Gly Leu Glu Glu Leu Glu Glu Val Glu Asp Lys Ile Ile Ile Arg
165 170 175Gly Asp Tyr Asn Ser Phe Lys Leu Leu Asn Glu Gly Phe Glu Ser Leu
180 185 190Lys Leu Pro Ile Leu Lys Ala Ser Leu Gln Arg Ile Ala Thr Thr Pro
195 200 205Ile Glu Leu Asn Asp Glu Gln Met Glu Leu Thr Glu Lys Leu Leu Asp
210 215 220Arg Ile Glu Asp Asp Asp Asp Val Val Ala Leu Tyr Thr Asn Ile Glu225 230 235 240
(2) Sequence 645 data:
(i) sequence characteristics:
(A) length: 451bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 108...392
(D) Other information:
(xi) Description of the sequence: sequence 645: ATCAGAGGGA TTACGCCTGG AAGGATAAGA ATTTTAGGGA TCTGTAAGAA GATCTAGAAG 60AAGCGATAGA ATACAACAAA AAGGGTCAGG GGCATTTTAT AGGCACC ATG GTT GTC 116
Met Val ValGCT AAG AAT GAA GAC AAC AAA AAA TTG TAT GAC ATC ATT GAC GGC CAG 164Ala Lys Asn Glu Asp Asn Lys Lys Leu Tyr Asp Ile Ile Asp Gly Gln
5 10 15CAA CGA ACG ACT ACC ATC TTC ATG CTC TTG CAT GTC TTG GCG AAC AAA 212Gln Arg Thr Thr Thr Ile Phe Met Leu Leu His Val Leu Ala Asn Lys20 25 30 35CAA AAC GAG AAA GAC AAG CAA GAA ACA AGA AAA TAT CTA TAC CAA AAG 260Gln Asn Glu Lys Asp Lys Gln Glu Thr Arg Lys Tyr Leu Tyr Gln Lys
40 45 50GGG GAA TTA AAA TTA GAA GTC GCC CCC AAA AAC CAA AGC TTC TTC AAA 308Gly Glu Leu Lys Leu Glu Val Ala Pro Lys Asn Gln Ser Phe Phe Lys
55 60 65ACG CTC TTG GAA GCG GCA GAA AAG GAG AAT ATC AGC CAG AAA AAG ATG 356Thr Leu Leu Glu Ala Ala Glu Lys Glu Asn Ile Ser Gln Lys Lys Met
70 75 80CAG ACA CCG AGG GCA AGC AAA ATC TTT TTG AAG TTT TGAAGGCTAT CTTGGA 408Gln Thr Pro Arg Ala Ser Lys Ile Phe Leu Lys Phe
85 90 95TAAGGTCAGC AAATTGAGTG AAGAAGAAGT GAATGAGCGT TTG 451
(2) Data of sequence 646:
(i) sequence characteristics:
(A) length: 95 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 646: met Val Val Ala Lys Asn Glu Asp Asn Lys Lys Leu Tyr Asp Ile Ile 151015 Asp Gly Gln Gln Arg Thr Thr Thr Ile Phe Met Leu Leu His Val Leu
20 25 30Ala Asn Lys Gln Asn Glu Lys Asp Lys Gln Glu Thr Arg Lys Tyr Leu
35 40 45Tyr Gln Lys Gly Glu Leu Lys Leu Glu Val Ala Pro Lys Asn Gln Ser
50 55 60Phe Phe Lys Thr Leu Leu Glu Ala Ala Glu Lys Glu Asn Ile Ser Gln65 70 75 80Lys Lys Met Gln Thr Pro Arg Ala Ser Lys Ile Phe Leu Lys Phe
85 90 95
(2) Sequence 647 data:
(i) sequence characteristics:
(A) length: 840bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 54...718
(D) Other information:
(xi) Description of the sequence: sequence 647: CAATGTCCAT GAGTTATTGG ACCAACACAA CGCTAACCTA AAAGGAGAAC ACC ATG 56
Met
1AGT GAT AAT GAA CGA ACG ATT GTA GTT AGA GTG CTA AAA TTT GAC CCT 104Ser Asp Asn Glu Arg Thr Ile Val Val Arg Val Leu Lys Phe Asp Pro
5 10 15CAA AGC GCG GTG AGT AAG CCG CAT TTT AAA GAG TAT CAG TTG AAA GAA 152Gln Ser Ala Val Ser Lys Pro His Phe Lys Glu Tyr Gln Leu Lys Glu
20 25 30ACG CCA TCC ATG ACG CTT TTT ATC GCT TTG AAC CTC ATT AGA GAG CAT 200Thr Pro Ser Met Thr Leu Phe Ile Ala Leu Asn Leu Ile Arg Glu His
35 40 45CAA GAT CCG GAT TTG AGT TTT GAT TTT GTG TGC CGC GCT GGG ATT TGC 248Gln Asp Pro Asp Leu Ser Phe Asp Phe Val Cys Arg Ala Gly Ile Cys50 55 60 65GGC TCT TGC GCG ATG ATG GTT AAT GGG AGA CCG AGG CTA GCT TGT AAA 296Gly Ser Cys Ala Met Met Val Asn Gly Arg Pro Arg Leu Ala Cys Lys
70 7580ACC CTA ACT TCT AGC TTT GAA AGC GGG GTG ATC ACG CTC ATG CCC ATG 344Thr Leu Thr Ser Ser Phe Glu Ser Gly Val Ile Thr Leu Met Pro Met
85 90 95CCC AGT TTT ACG CTC ATT AAA GAT TTG AGC GTG AAT ACG GGC GAT TGG 392Pro Ser Phe Thr Leu Ile Lys Asp Leu Ser Val Asn Thr Gly Asp Trp
100 105 110TTT TTG GAT ATG ACT AAA AGG GTG GAG AGT TGG GCG CAT TCT AAA GAA 440Phe Leu Asp Met Thr Lys Arg Val Glu Ser Trp Ala His Ser Lys Glu
115 120 125GAA GTG GAT ATT ACT AGA CCG GAA AAA AGG GTT GAG CCT GAC GAA GCC 488Glu Val Asp Ile Thr Arg Pro Glu Lys Arg Val Glu Pro Asp Glu Ala130 135 140 145CAA GAA GTC TTT GAA CTA GAC AGG TGT ATT GAA TGC GGG TGT TGT ATC 536Gln Glu Val Phe Glu Leu Asp Arg Cys Ile Glu Cys Gly Cys Cys Ile
150 155 160GCT TCT TGC GGG ACT AAA CTC ATG CGC CCT AAT TTC ATT GGA GCT GCT 584Ala Ser Cys Gly Thr Lys Leu Met Arg Pro Asn Phe Ile Gly Ala Ala
165 170 175GGC ATG AAC AGA GCC ATG CGT TTT ATG ATT GAC AGC CAC GAT GAA AGA 632Gly Met Asn Arg Ala Met Arg Phe Met Ile Asp Ser His Asp Glu Arg
180 185 190AAC GAT GAT GAT TTT TAT GAG TTA GTC GGC GAT GAT GAT GGT GTT TTT 680Asn Asp Asp Asp Phe Tyr Glu Leu Val Gly Asp Asp Asp Gly Val Phe
195 200 205GGG TGC ATG AGC CTT ATC GCT TGC CAT GAC ACT TGC CC TAAAGAATTA CCC 731Gly Cys Met Ser Leu Ile Ala Cys His Asp Thr Cys Pro210 215 220TTGCAAAGCA GTATCGCCAC TTTGCGTAAC AGGATGTTGA AAGTGGGTAA AAGCCGCTAA 791TTTCTTTTTA GTGGGTCGTT TTTGAAAATC TTTTTAGTCT TTTTAAGCG 840
(2) Sequence 648 data:
(i) sequence characteristics:
(A) length: 222 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 648: met Ser Asp Asn Glu Arg Thr Ile Val Val Arg Val Leu Lys Phe Asp 151015 Pro Gln Ser Ala Val Ser Lys Pro His Phe Lys Glu Tyr Gln Leu Lys
20 25 30Glu Thr Pro Ser Met Thr Leu Phe Ile Ala Leu Asn Leu Ile Arg Glu
35 40 45His Gln Asp Pro Asp Leu Ser Phe Asp Phe Val Cys Arg Ala Gly Ile
50 55 60Cys Gly Ser Cys Ala Met Met Val Asn Gly Arg Pro Arg Leu Ala Cys65 70 75 80Lys Thr Leu Thr Ser Ser Phe Glu Ser Gly Val Ile Thr Leu Met Pro
85 90 95Met Pro Ser Phe Thr Leu Ile Lys Asp Leu Ser Val Asn Thr Gly Asp
100 105 110Trp Phe Leu Asp Met Thr Lys Arg Val Glu Ser Trp Ala His Ser Lys
115 120 125Glu Glu Val Asp Ile Thr Arg Pro Glu Lys Arg Val Glu Pro Asp Glu
130 135 140Ala Gln Glu Val Phe Glu Leu Asp Arg Cys lle Glu Cys Gly Cys Cys145 150 155 160Ile Ala Ser Cys Gly Thr Lys Leu Met Arg Pro Asn Phe Ile Gly Ala
165 170 175Ala Gly Met Asn Arg Ala Met Arg Phe Met Ile Asp Ser His Asp Glu
180 185 190Arg Asn Asp Asp Asp Phe Tyr Glu Leu Val Gly Asp Asp Asp Gly Val
195 200 205Phe Gly Cys Met Ser Leu Ile Ala Cys His Asp Thr Cys Pro210 215 220
(2) Sequence 649 data: (i) sequence characteristics:
(A) length: 351bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 53...262
(D) Other information: (xi) sequence description: sequence 649: GAAAGCCAAA GTAGCCCCTT GATTGAAACA AGATTGAGCG ATCCCATAAG CG ATG GAT 58
Met Asp
1TTA TTG TTC GCC ACC CCT ACA ATA AGC CCT TTT TTA CCT TTT AAA AAT 106Leu Leu Phe Ala Thr Pro Thr Ile Ser Pro Phe Leu Pro Phe Lys Asn
5 10 15CCC ATG ATT TTC CTT TAT AAA AAT GAA ATG ATT GTT TTA AAA TTT TCT 154Pro Met Ile Phe Leu Tyr Lys Asn Glu Met Ile Val Leu Lys Phe Ser
20 25 30AAT TCC CAA GAC GCG CTC CCG ATC AAC AAG CCA TCC ACG CTA TCA ATC 202Asn Ser Gln Asp Ala Leu Pro Ile Asn Lys Pro Ser Thr Leu Ser Ile35 40 4550CCT AAA ATT TCT TTA GCG TTT TGT GTG TTC ACG CTC CCC CCA TAC AAC 250Pro Lys Ile Ser Leu Ala Phe Cys Val Phe Thr Leu Pro Pro Tyr Asn
55 60 65AAG GGC GTT TTT TGATTTAAGA TTTGCTTTAA AAAACCATGC GTGAGATAAA TATCT 307Lys Gly Val Phe
70TCTAAAGAAG CGCTTTTTTT GGTGCCAATC GCCCAAATAG GCTC 351
(2) Sequence 650 data:
(i) sequence characteristics:
(A) length: 70 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 650: met Asp Leu Leu Phe Ala Thr Pro Thr Ile Ser Pro Phe Leu Pro Phe 151015 Lys Asn Pro Met Ile Phe Leu Tyr Lys Asn Glu Met Ile Val Leu Lys
20 25 30Phe Ser Asn Ser Gln Asp Ala Leu Pro Ile Asn Lys Pro Ser Thr Leu
35 40 45Ser Ile Pro Lys Ile Ser Leu Ala Phe Cys Val Phe Thr Leu Pro Pro
50 55 60Tyr Asn Lys Gly Val Phe65 70
(2) Sequence 651 data:
(i) sequence characteristics:
(A) length: 1271bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 368...1210
(D) Other information: (xi) Description of the sequence: sequence 65 l: TTTAAGGACT ATGCATGCAA GAGATTATCC CTATTGTCGT GGCTTTTGAT AACAACTATT 60GTATCCCTGC TGGCGTGAGC TTATTTTCCA TGCTAGCAAA CGCCAAACGA GAGAGAGAGA 120GAGAGAGAGA GTAAAACTCT TTTATCAAAT CCATTGTTTG GTGGAGAGTT TAACCCCAGA 180GAATATAGCC AAATTAGAAG AAACGATCGC TCCTTTTAGA GCTTTTTCTA GCATAGAGTT 240TTTGGATATT ACCGATAAAG AATTAGAACC ACGCCACAAT TATAATAAGC TTGATCCTTT 300AATAGCGAGT GAAATTAAAA AATTGTATTT AAAACTCAAT GCTTTTTCGC AAAAACGCTT 360TTCTAAA ATG ATC ATG TGC CGT TTC TTT TTT GCC TCC CTT TTC CCC CAA 409
Met Ile Met Cys Arg Phe Phe Phe Ala Ser Leu Phe Pro Gln
1 5 10TAC GAT AAG ATG ATC ATG TTT GAT GTG GAC ACT TTG TTT GTG AAT GAT 457Tyr Asp Lys Met Ile Met Phe Asp Val Asp Thr Leu Phe Val Asn Asp15 20 25 30ATT AGC GAG AGC TTT TTT ATC CCC CTT GAA ACG CAT TAT TTT GGG GCT 505Ile Ser Glu Ser Phe Phe Ile Pro Leu Glu Thr His Tyr Phe Gly Ala
35 40 45GTG AGG GAA AAA GAT TTG ATC GCT ATA AAT AGG AAT TCG GCT AAG GAT 553Val Arg Glu Lys Asp Leu Ile Ala Ile Asn Arg Asn Ser Ala Lys Asp
50 55 60TTA TAC GAA TTG CGC CAA ATG CAT GCA AAA TCT ATC GGC ATC GCC AAC 601Leu Tyr Glu Leu Arg Gln Met His Ala Lys Ser Ile Gly Ile Ala Asn
65 70 75GCT TTC CCT AAT TTA GAA GAA GCT CAA ATC CTT TTT GAC AAC TAC TTT 649Ala Phe Pro Asn Leu Glu Glu Ala Gln Ile Leu Phe Asp Asn Tyr Phe
80 85 90AAC GCC GGG TTT TTA GCC TTA AAT TTA AAA TCA TGG CGT AAA GAA AAT 697Asn Ala Gly Phe Leu Ala Leu Asn Leu Lys Ser Trp Arg Lys Glu Asn95 100 105 110CTT GAA AAC CAA TTG ATT ACC TTT TTC ATT TTG AAA AAT GAA AAA CTT 745Leu Glu Asn Gln Leu Ile Thr Phe Phe Ile Leu Lys Asn Glu Lys Leu
115 120 125TTA TTT AAC GAT CAA GAT GCT TTG TGT TTT GTG TGC CGT GGG AGG ATT 793Leu Phe Asn Asp Gln Asp Ala Leu Cys Phe Val Cys Arg Gly Arg Ile
130 135 140TTA GAA TTG CCT TAT CCA TAC AAT GCC CAC CCT AGT TTC CTT GAT ACG 841Leu Glu Leu Pro Tyr Pro Tyr Asn Ala His Pro Ser Phe Leu Asp Thr
145 150 155CTC TCA TTC CCT AGC ATC AAA GAA GCG CGC ATG CTG CAT TTT TGG GGC 889Leu Ser Phe Pro Ser Ile Lys Glu Ala Arg Met Leu His Phe Trp Gly
160 165 170GAT AAA CCC TGG AAA CTC TTA AGC GTC ATT GGC GCG AAA AAA TGG CAT 937Asp Lys Pro Trp Lys Leu Leu Ser Val Ile Gly Ala Lys Lys Trp His175 180 185 190GAA GCG TTG ATC CAA ACG CCT TTT AAA GAC GCC TAT TTC AAC GCT TCT 985Glu Ala Leu Ile Gln Thr Pro Phe Lys Asp Ala Tyr Phe Asn Ala Ser
195 200 205TTT TTA GAT CAC CTC TTT GAA TCC CTT CAA AAC AAG GAT AAT GAG ATC 1033Phe Leu Asp His Leu Phe Glu Ser Leu Gln Asn Lys Asp Asn Glu Ile
210 215 220AAA AGA AGA GAT GAA AGG ATC ATT GAA GCA CTT CAA GCA AGG GAT AAA 1081Lys Arg Arg Asp Glu Arg Ile Ile Glu Ala Leu Gln Ala Arg Asp Lys
225 230 235ATC CTG TCT TTT TCA GAC AAG CGA CAT TCT TTT GAA TCT CTT CTG CCC 1129Ile Leu Ser Phe Ser Asp Lys Arg His Ser Phe Glu Ser Leu Leu Pro
240 245 250AAG CTT TCT TCT AAA CTC CTT ATA GAA TTT TTG CTT TTT AAA GCC AAA 1177Lys Leu Ser Ser Lys Leu Leu Ile Glu Phe Leu Leu Phe Lys Ala Lys255 260 265 270CAA AAA GTG AAG CGA CTG ATT AAA AGG GTT TTT TAAAACCCTT TTTAAACTAA 1230Gln Lys Val Lys Arg Leu Ile Lys Arg Val Phe
275 280TGCGAGCAAG CATGGGTTTG TGTGGGCTGG ATGTCCTTAT T 1271
(2) Sequence 652 data: (i) sequence characteristics: length (A): 281 amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 652: met Ile Met Cys Arg Phe Phe Phe Ala Ser Leu Phe Pro Gln Tyr Asp 151015 Lys Met Ile Met Phe Asp Val Asp Thr Leu Phe Val Asn Asp Ile Ser
20 25 30Glu Ser Phe Phe Ile Pro Leu Glu Thr His Tyr Phe Gly Ala Val Arg
35 40 45Glu Lys Asp Leu Ile Ala lle Asn Arg Asn Ser Ala Lys Asp Leu Tyr
50 55 60Glu Leu Arg Gln Met His Ala Lys Ser Ile Gly Ile Ala Asn Ala Phe65 70 75 80Pro Asn Leu Glu Glu Ala Gln Ile Leu Phe Asp Asn Tyr Phe Asn Ala
85 90 95Gly Phe Leu Ala Leu Asn Leu Lys Ser Trp Arg Lys Glu Asn Leu Glu
100 105 110Asn Gln Leu Ile Thr Phe Phe Ile Leu Lys Asn Glu Lys Leu Leu Phe
115 120125Asn Asp Gln Asp Ala Leu Cys Phe Val Cys Arg Gly Arg Ile Leu Glu
130 135 140Leu Pro Tyr Pro Tyr Asn Ala His Pro Ser Phe Leu Asp Thr Leu Ser145 150 155 160Phe Pro Ser Ile Lys Glu Ala Arg Met Leu His Phe Trp Gly Asp Lys
165 170 175Pro Trp Lys Leu Leu Ser Val Ile Gly Ala Lys Lys Trp His Glu Ala
180 185 190Leu Ile Gln Thr Pro Phe Lys Asp Ala Tyr Phe Asn Ala Ser Phe Leu
195 200 205Asp His Leu Phe Glu Ser Leu Gln Asn Lys Asp Asn Glu Ile Lys Arg
210 215 220Arg Asp Glu Arg Ile Ile Glu Ala Leu Gln Ala Arg Asp Lys Ile Leu225 230 235 240Ser Phe Ser Asp Lys Arg His Ser Phe Glu Ser Leu Leu Pro Lys Leu
245 250 255Ser Ser Lys Leu Leu Ile Glu Phe Leu Leu Phe Lys Ala Lys Gln Lys
260 265 270Val Lys Arg Leu Ile Lys Arg Val Phe
275 280
(2) Sequence 653 data: (i) sequence characteristics: length (A): 1198bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1145 (D) other information: (xi) Description of the sequence: sequence 653: ATTTAGACAA TAACGCTACA ACTAGGATTG ACCCTAAAGT CAAAGAGATC ATG GAT 56
Met Asp
1CCT TTT TTA AGG GAT CAT TAT GGG AAT CCT AGC TCG TTG CAC CAG TTT 104Pro Phe Leu Arg Asp His Tyr Gly Asn Pro Ser Ser Leu His Gln Phe
5 10 15GGC ACA GAA ACC CAC CCA GCC ATT GCA GAA GCG CTA GAT AAG CTT TAT 152Gly Thr Glu Thr His Pro Ala Ile Ala Glu Ala Leu Asp Lys Leu Tyr
20 25 30AAG GGC ATT AAC GCT AGG GAT ATA GAT GAT GTG ATC ATC ACT TCT TGT 200Lys Gly Ile Asn Ala Arg Asp Ile Asp Asp Val Ile Ile Thr Ser Cys35 40 45 50GCG ACA GAA AGC AAT AAT TGG GTT TTA AAG GGC GTG TAT TTT GAT GAA 248Ala Thr Glu Ser Asn Asn Trp Val Leu Lys Gly Val Tyr Phe Asp Glu
55 60 65TGC TTG AAA AAA GGC AAA AAC CAT ATT GTA ACC ACG GTT GCA GAG CAT 296Cys Leu Lys Lys Gly Lys Asn His Ile Val Thr Thr Val Ala Glu His
70 75 80CCG GCG GTG CGA TCC ACT TGC AAT TTT TTA GAA AGC TTG GGG GTG GAG 344Pro Ala Val Arg Ser Thr Cys Asn Phe Leu Glu Ser Leu Gly Val Glu
85 90 95GTT ACT TAC TTG CCC ATT AAT GAG CAT GGG AGC ATC ACC GCA GAG CAA 392Val Thr Tyr Leu Pro Ile Asn Glu His Gly Ser Ile Thr Ala Glu Gln
100 105 110GTC AAA GAA GCG ATC ACA GAA AAA ACC GCT CTA GTG AGC GTG ATG TGG 440Val Lys Glu Ala Ile Thr Glu Lys Thr Ala Leu Val Ser Val Met Trp115 120 125 130GCG AAT AAT GAA ACC GGT CTC ATT TTC CCT ATT GAA GAA ATT GGG GCT 488Ala Asn Asn Glu Thr Gly Leu Ile Phe Pro Ile Glu Glu Ile Gly Ala
135 140 145ATT TGT AAA GAA AAG GGC GTG TTG TTC CAT ACC GAT GCC GTG CAA GCG 536Ile Cys Lys Glu Lys Gly Val Leu Phe His Thr Asp Ala Val Gln Ala
150 155 160ATT GGT AAA ATC CCT GTA GAT GTG TTA AAA GCG AAT GCA GAT TTC CTT 584Ile Gly Lys Ile Pro Val Asp Val Leu Lys Ala Asn Ala Asp Phe Leu
165 170 175TCT TTT AGC GCG CAC AAG TTT CAT GGG CCT AAA GGC ATT GGG GGG TTG 632Ser Phe Ser Ala His Lys Phe His Gly Pro Lys Gly Ile Gly Gly Leu
180 185 190TAT ATT AGA AGT GGG GTG GGA TTG ACC CCT CTT TTT CAT GGC GGG GAG 680Tyr Ile Arg Ser Gly Val Gly Leu Thr Pro Leu Phe His Gly Gly Glu195 200 205 210CAT ATG AAT GGC AGG CGC AGC GGG ACT TTG AAT GTG CCT TAT ATT GTG 728His Met Asn Gly Arg Arg Ser Gly Thr Leu Asn Val Pro Tyr Ile Val
215 220 225GGA ATG GGC GAA GCG ATG AAA TTA GCC GTA GAG CAT TTA GAC TAT GAA 776Gly Met Gly Glu Ala Met Lys Leu Ala Val Glu His Leu Asp Tyr Glu
230 235 240AAA GAA GTG GTG GGG AAA TTG CGC GAC AAA TTA GAA GAA GCG CTT TTG 824Lys Glu Val Val Gly Lys Leu Arg Asp Lys Leu Glu Glu Ala Leu Leu
245 250 255AAA ATC CCT GAT GTG ATG GTG GTG GGC GAT AGA ATC CAT CGT GTG CCT 872Lys Ile Pro Asp Val Met Val Val Gly Asp Arg Ile His Arg Val Pro
260 265 270AAC ACG ACT TTA GTC AGC GTG AGA GGG ATT GAA GGA GAG GCC ATG CTG 920Asn Thr Thr Leu Val Ser Val Arg Gly Ile Glu Gly Glu Ala Met Leu275 280 285 290TGG GAT TTA AAC CGC TCT AAT ATC GCC GCT TCC ACA GGG AGC GCG TGC 968Trp Asp Leu Asn Arg Ser Asn Ile Ala Ala Ser Thr Gly Ser Ala Cys
295 300 305GCG AGT GAG GAT TTA GAG GCT AAT CCG GTG ATG GTA GCG ATT GGA GCG 1016Ala Ser Glu Asp Leu Glu Ala Asn Pro Val Met Val Ala Ile Gly Ala
310 315 320AGT AAG GAA TTG GCT CAT ACC GCT ATC AGG CTT TCA TTG AGC CGT TTT 1064Ser Lys Glu Leu Ala His Thr Ala Ile Arg Leu Ser Leu Ser Arg Phe
325 330 335AAC ACG GAA GCT GAA ATT GAC AAA ACG ATT GAA GTT TTC TCT CAA GCG 1112Asn Thr Glu Ala Glu Ile Asp Lys Thr Ile Glu Val Phe Ser Gln Ala
340 345 350GCT GTA AGG TTG AGA AAT ATT TCA AGC TCT TAT TAAAAAGAAT ATAAAGGAAT 1165Ala Val Arg Leu Arg Asn Ile Ser Ser Ser Tyr355 360 365CAAAATGGCA AAACATGATT TAGTGGGTTC GGT 1198
(2) Sequence 654 data:
(i) sequence characteristics:
(A) length: 365 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 654: met Asp Pro Phe Leu Arg Asp His Tyr Gly Asn Pro Ser Ser Leu His 151015 Gln Phe Gly Thr Glu Thr His Pro Ala Ile Ala Glu Ala Leu Asp Lys
20 25 30Leu Tyr Lys Gly Ile Asn Ala Arg Asp Ile Asp Asp Val Ile Ile Thr
35 40 45Ser Cys Ala Thr Glu Ser Asn Asn Trp Val Leu Lys Gly Val Tyr Phe
50 55 60Asp Glu Cys Leu Lys Lys Gly Lys Asn His Ile Val Thr Thr Val Ala65 70 75 80Glu His Pro Ala Val Arg Ser Thr Cys Asn Phe Leu Glu Ser Leu Gly
85 90 95Val Glu Val Thr Tyr Leu Pro Ile Asn Glu His Gly Ser Ile Thr Ala
100 105 110Glu Gln Val Lys Glu Ala Ile Thr Glu Lys Thr Ala Leu Val Ser Val
115 120 125Met Trp Ala Asn Asn Glu Thr Gly Leu Ile Phe Pro Ile Glu Glu Ile
130 135 140Gly Ala Ile Cys Lys Glu Lys Gly Val Leu Phe His Thr Asp Ala Val145 150 155 160Gln Ala Ile Gly Lys Ile Pro Val Asp Val Leu Lys Ala Asn Ala Asp
165 170 175Phe Leu Ser Phe Ser Ala His Lys Phe His Gly Pro Lys Gly Ile Gly
180 185 190Gly Leu Tyr Ile Arg Ser Gly Val Gly Leu Thr Pro Leu Phe His Gly
195 200 205Gly Glu His Met Asn Gly Arg Arg Ser Gly Thr Leu Asn Val Pro Tyr
210 215 220Ile Val Gly Met Gly Glu Ala Met Lys Leu Ala Val Glu His Leu Asp225 230 235 240Tyr Glu Lys Glu Val Val Gly Lys Leu Arg Asp Lys Leu Glu Glu Ala
245 250 255Leu Leu Lys Ile Pro Asp Val Met Val Val Gly Asp Arg Ile His Arg
260 265 270Val Pro Asn Thr Thr Leu Val Ser Val Arg Gly Ile Glu Gly Glu Ala
275280 285Met Leu Trp Asp Leu Asn Arg Ser Asn Ile Ala Ala Ser Thr Gly Ser
290 295 300Ala Cys Ala Ser Glu Asp Leu Glu Ala Asn Pro Val Met Val Ala Ile305 310 315 320Gly Ala Ser Lys Glu Leu Ala His Thr Ala Ile Arg Leu Ser Leu Ser
325 330 335Arg Phe Asn Thr Glu Ala Glu Ile Asp Lys Thr Ile Glu Val Phe Ser
340 345 350Gln Ala Ala Val Arg Leu Arg Asn Ile Ser Ser Ser Tyr
355 360 365
(2) Sequence 655 data: (i) sequence characteristics: length (A): 1273bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1220 (D) other information: (xi) Description of the sequence: sequence 655: TCCGGTTTGA AGTTGGTTTT TAAATCTTTG GCTATAATCA AGCCATTCTA ATG AGA 56
Met Arg
1AAG AAA GGC ATG TTT GAA AAG ATA CAA AAA GAA TGG CTG AGC AAC ATT 104Lys Lys Gly Met Phe Glu Lys Ile Gln Lys Glu Trp Leu Ser Asn Ile
5 10 15CAA AAG GAT TTG TTG TCT GGT TTT GTG GTG GGG CTT TCT GTG ATC CCA 152Gln Lys Asp Leu Leu Ser Gly Phe Val Val Gly Leu Ser Val Ile Pro
20 25 30GAG ACG GCC GGC TTT GCG ATC ATG GTG GGT TTA GAT GTG GGC GTG GCG 200Glu Thr Ala Gly Phe Ala Ile Met Val Gly Leu Asp Val Gly Val Ala35 40 45 50TTT TAT ACG ACC TTTTAC ATG GCT TTT GTT TTG TCT CTT TTT GGG GCT 248Phe Tyr Thr Thr Phe Tyr Met Ala Phe Val Leu Ser Leu Phe Gly Ala
55 60 65AGA AAG GCG ATG ATT AGC GCA GCG GCC GGC TCA GTG GCG CTC ATT TTA 296Arg Lys Ala Met Ile Ser Ala Ala Ala Gly Ser Val Ala Leu Ile Leu
70 75 80GTG GGC GTG GTT AAA AAC TAT GGG CTT GAA TAC GCG GGC GTG GCG ACT 344Val Gly Val Val Lys Asn Tyr Gly Leu Glu Tyr Ala Gly Val Ala Thr
85 90 95CTT ATG GCA GGG GTG TTG CAA ATT CTT TTA GGC TAT TTG AAA ATA GGG 392Leu Met Ala Gly Val Leu Gln Ile Leu Leu Gly Tyr Leu Lys Ile Gly
100 105 110AAT CTT TTG AGG TTT ATC CCC CAA TCA GTG ATG TAT GGC TTT GTG AAC 440Asn Leu Leu Arg Phe Ile Pro Gln Ser Val Met Tyr Gly Phe Val Asn115 120 125 130GCG CTA GGC ATT TTG CTT TTA ATG GAG CAA TTC AAA TTC CTT CAA AAC 488Ala Leu Gly Ile Leu Leu Leu Met Glu Gln Phe Lys Phe Leu Gln Asn
135 140 145CAA AAT TTG GGG GTG TTT GTC TTG CTC GCT ATT GGG ATA CTC ATC ATT 536Gln Asn Leu Gly Val Phe Val Leu Leu Ala Ile Gly Ile Leu Ile Ile
150 155 160TAT CTT TTT CCT CTA ATC ACT AAA AAA ATC CCC TCT AAT CTG ATT TGT 584Tyr Leu Phe Pro Leu Ile Thr Lys Lys Ile Pro Ser Asn Leu Ile Cys
165 170 175ATC CTT ATA GTG AGC GCG ATC GCT TTA ATT TTT GAT ATG CAT GCG CCG 632Ile Leu Ile Val Ser Ala Ile Ala Leu Ile Phe Asp Met His Ala Pro
180 185 190AAT TTG GGG AGC ATT GAG CAA GGG GTT TCA GGC TTT CAT TTC ATC ATT 680Asn Leu Gly Ser Ile Glu Gln Gly Val Ser Gly Phe His Phe Ile Ile195 200 205 210ATC CCC AAA AAT TTG GAT TTT AAA ATA ATG ATA GAG TTG TTG CCT TAC 728Ile Pro Lys Asn Leu Asp Phe Lys Ile Met Ile Glu Leu Leu Pro Tyr
215 220 225GCT CTT TCT TTA GCA CTA GTG GGA ACG ATA GAA AGC TTA TTG ACG GCT 776Ala Leu Ser Leu Ala Leu Val Gly Thr Ile Glu Ser Leu Leu Thr Ala
230 235 240AAA ACT TTA GAT GTG ATT TTA AAA GAC GGC GTG AGC GAT AAA AAT AAA 824Lys Thr Leu Asp Val Ile Leu Lys Asp Gly Val Ser Asp Lys Asn Lys
245 250 255GAA ACT AAA GCG CAA GGC TTG GGG AAT ATC ATC TCA GGG CTT TTG GGG 872Glu Thr Lys Ala Gln Gly Leu Gly Asn Ile Ile Ser Gly Leu Leu Gly
260 265 270GGA ATG ACA GGG TGC GCT TTA GTG GGG CAG TCT ATC ATT AAC GCA AAA 920Gly Met Thr Gly Cys Ala Leu Val Gly Gln Ser Ile Ile Asn Ala Lys275 280 285 290TCC GGG GCT AAA ACA AGG CTT TCT ACT TTT TTT GCC GGC TTT TCT TTA 968Ser Gly Ala Lys Thr Arg Leu Ser Thr Phe Phe Ala Gly Phe Ser Leu
295 300 305ATG GTG CTC ATA TTA GTG TTT AAT GAA TAT GTG GTT AAG ATC CCC ATT 1016Met Val Leu Ile Leu Val Phe Asn Glu Tyr Val Val Lys Ile Pro Ile
310 315 320GTG GCG GTT GTG GCG GTA ATG GTG ATG ATT TCT TTC ACC ACT TTT AAT 1064Val Ala Val Val Ala Val Met Val Met Ile Ser Phe Thr Thr Phe Asn
325 330 335TTC CAA TCC ATT ATT AAC ATT AAA AAA ATC AAG CTC TAT GAC ACG CTC 1112Phe Gln Ser Ile Ile Asn Ile Lys Lys Ile Lys Leu Tyr Asp Thr Leu
340 345 350AAC ATG CTC TTA GTC GTG GCG GTG GTT TTA TAC ACG CAT AAT TTA GCG 1160Asn Met Leu Leu Val Val Ala Val Val Leu Tyr Thr His Asn Leu Ala355 360 365 370ATA GGG GTT GTG GTG GGG GTT TTA GTC AAT GCG TTA TGG ATC AAA TCT 1208Ile Gly Val Val Val Gly Val Leu Val Asn Ala Leu Trp Ile Lys Ser
375 380 385AAA GGG ATT GCA TGAAATTTTA TTTTAAAAAG TTGGGTAGCT AGAGATATGG CTCCA 1265Lys Gly Ile Ala
390GATGTAGG 1273
(2) Sequence 656 data: (i) sequence characteristics: length (A): 390 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 656: met Arg Lys Lys Gly Met Phe Glu Lys Ile Gln Lys Glu Trp Leu Ser 151015 Asn Ile Gln Lys Asp Leu Leu Ser Gly Phe Val Val Gly Leu Ser Val
20 25 30Ile Pro Glu Thr Ala Gly Phe Ala Ile Met Val Gly Leu Asp Val Gly
35 40 45Val Ala Phe Tyr Thr Thr Phe Tyr Met Ala Phe Val Leu Ser Leu Phe
50 55 60Gly Ala Arg Lys Ala Met Ile Ser Ala Ala Ala Gly Ser Val Ala Leu65 70 75 80Ile Leu Val Gly Val Val Lys Asn Tyr Gly Leu Glu Tyr Ala Gly Val
85 90 95Ala Thr Leu Met Ala Gly Val Leu Gln Ile Leu Leu Gly Tyr Leu Lys
100 105 110Ile Gly Asn Leu Leu Arg Phe Ile Pro Gln Ser Val Met Tyr Gly Phe
115 120 125Val Asn Ala Leu Gly Ile Leu Leu Leu Met Glu Gln Phe Lys Phe Leu
130 135 140Gln Asn Gln Asn Leu Gly Val Phe Val Leu Leu Ala Ile Gly Ile Leu145 150 155 160Ile Ile Tyr Leu Phe Pro Leu Ile Thr Lys Lys Ile Pro Ser Asn Leu
165 170 175Ile Cys Ile Leu Ile Val Ser Ala Ile Ala Leu Ile Phe Asp Met His
180 185 190Ala Pro Asn Leu Gly Ser Ile Glu Gln Gly Val Ser Gly Phe His Phe
195 200 205Ile Ile Ile Pro Lys Asn Leu Asp Phe Lys Ile Met Ile Glu Leu Leu
210 215 220Pro Tyr Ala Leu Ser Leu Ala Leu Val Gly Thr Ile Glu Ser Leu Leu225 230 235 240Thr Ala Lys Thr Leu Asp Val Ile Leu Lys Asp Gly Val Ser Asp Lys
245 250 255Asn Lys Glu Thr Lys Ala Gln Gly Leu Gly Asn Ile Ile Ser Gly Leu
260 265 270Leu Gly Gly Met Thr Gly Cys Ala Leu Val Gly Gln Ser Ile Ile Asn
275 280 285Ala Lys Ser Gly Ala Lys Thr Arg Leu Ser Thr Phe Phe Ala Gly Phe
290 295 300Ser Leu Met Val Leu Ile Leu Val Phe Asn Glu Tyr Val Val Lys Ile305 310 315 320Pro Ile Val Ala Val Val Ala Val Met Val Met Ile Ser Phe Thr Thr
325 330 335Phe Asn Phe Gln Ser Ile Ile Asn Ile Lys Lys Ile Lys Leu Tyr Asp
340 345 350Thr Leu Asn Met Leu Leu Val Val Ala Val Val Leu Tyr Thr His Asn
355 360 365Leu Ala Ile Gly Val Val Val Gly Val Leu Val Asn Ala Leu Trp Ile
370 375 380Lys Ser Lys Gly Ile Ala385 390
(2) Sequence 657 data: (i) sequence characteristics: length (A): 1020bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 964 (D) other information: (xi) Description of the sequence: sequence 657: GAAGAAAAAA TTTTAGAAAT GTTAGAAAGC GAATAAGGGG GAGTGAGTGG GAAATTTAGT 60GATTGGCTCT AGGGGGAGCG AATTAGCCTT ATGGCAAGCG AATCACATTA AAGAACGCCT 120GAAAAAAGAA TGCTTGATAG AAAGCGAAAT TCAAATCGTT AAGACTAAGG GCGATAAAAT 180CTTAGACACC CCTTTAAATA AGATCGGCGG TAAGGGGCTA TTCACTAAGG AATTAGAAGA 240ATTGCTTTTA AAGGGCGCAA TTGATTTGGC GGTGCATTCT TTAAAAGACG TGCCGGTCGT 300GTTTGAAAAG GGGTTAGACT TGGCATGCAT CACCAAAAGG GCTGATGTGA GGGACACTTT 360TTTAAGCGTG AAATTCCCTG ATTTG ATG AGT TTG CCT AAA GGG GCA AAG GTT 412
Met Ser Leu Pro Lys Gly Ala Lys Val
1 5GGC ACG ACT TCT TTA AGG CGC TCT ATG CAG ATC AAA TTA AAG CGC CAG 460Gly Thr Thr Ser Leu Arg Arg Ser Met Gln Ile Lys Leu Lys Arg Gln10 15 20 25GAT TTG GAC ACA GAA AGC TTG AGA GGG AAT GTC CAA ACC CGT TTG AAA 508Asp Leu Asp Thr Glu Ser Leu Arg Gly Asn Val Gln Thr Arg Leu Lys
30 35 40AAG CTT GAA TGC GGA GAA TTT GAC GCT ATC ATT TTA GCT GAA GCC GGG 556Lys Leu Glu Cys Gly Glu Phe Asp Ala Ile Ile Leu Ala Glu Ala Gly
4550 55TTG TGC CGC CTA GAA ATT CAA GGA GCG AAA TAC CGC AAG GCT TTT AGC 604Leu Cys Arg Leu Glu Ile Gln Gly Ala Lys Tyr Arg Lys Ala Phe Ser
60 65 70GTA GAA GAA ATG ATT CCT AGC ATG GGT CAG GGG GCT TTA GGG GTA GAA 652Val Glu Glu Met Ile Pro Ser Met Gly Gln Gly Ala Leu Gly Val Glu
75 80 85ATG CTC AAA AAC CAC AAG CAT TTT GCC ACG CTT CAA AAA CTC AAC GAC 700Met Leu Lys Asn His Lys His Phe Ala Thr Leu Gln Lys Leu Asn Asp90 95 100 105GAG AAA AGC GCG TTT TGC TGC CGT TTA GAA AGG GAG TTT ATC AAG GGG 748Glu Lys Ser Ala Phe Cys Cys Arg Leu Glu Arg Glu Phe Ile Lys Gly
110 115 120CTT AAT GGA GGG TGT CAG ATC CCT ATA GGC GTG CAT GCG AGT TTA ATG 796Leu Asn Gly Gly Cys Gln Ile Pro Ile Gly Val His Ala Ser Leu Met
125 130 135GGC GAT AGG GTT AAA ATC CAG GCG GTT TTA GGC TTG CCT AAC GGG AAA 844Gly Asp Arg Val Lys Ile Gln Ala Val Leu Gly Leu Pro Asn Gly Lys
140 145 150GAA GTC ATT ACT AAA GAA AAA CAA GGG GAT AAA ACT AAA GCG TTT GAT 892Glu Val Ile Thr Lys Glu Lys Gln Gly Asp Lys Thr Lys Ala Phe Asp
155 160 165TTA GTT CAA GAG CTT TTA GAA GAA TTT TTG CAA AGC GGG GCT AAA GAG 940Leu Val Gln Glu Leu Leu Glu Glu Phe Leu Gln Ser Gly Ala Lys Glu170 175 180 185ATT TTA GAA AAG GCG CAG TTG TTT TAATGCGTTT GTTTATCGCG CTAGTTTTGT 994Ile Leu Glu Lys Ala Gln Leu Phe
190TTTGGTGGTG GTTAAGCTTG AACGCT 1020
(2) Sequence658 data:
(i) sequence characteristics:
(A) length: 193 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 658: met Ser Leu Pro Lys Gly Ala Lys Val Gly Thr Thr Ser Leu Arg Arg 151015 Ser Met Gln Ile Lys Leu Lys Arg Gln Asp Leu Asp Thr Glu Ser Leu
20 25 30Arg Gly Asn Val Gln Thr Arg Leu Lys Lys Leu Glu Cys Gly Glu Phe
35 40 45Asp Ala Ile Ile Leu Ala Glu Ala Gly Leu Cys Arg Leu Glu Ile Gln
50 55 60Gly Ala Lys Tyr Arg Lys Ala Phe Ser Val Glu Glu Met Ile Pro Ser65 70 75 80Met Gly Gln Gly Ala Leu Gly Val Glu Met Leu Lys Asn His Lys His
85 90 95Phe Ala Thr Leu Gln Lys Leu Asn Asp Glu Lys Ser Ala Phe Cys Cys
100 105 110Arg Leu Glu Arg Glu Phe Ile Lys Gly Leu Asn Gly Gly Cys Gln Ile
115 120 125Pro Ile Gly Val His Ala Ser Leu Met Gly Asp Arg Val Lys Ile Gln
130 135 140Ala Val Leu Gly Leu Pro Asn Gly Lys Glu Val Ile Thr Lys Glu Lys145 150 155 160Gln Gly Asp Lys Thr Lys Ala Phe Asp Leu Val Gln Glu Leu Leu Glu
165170 175Glu Phe Leu Gln Ser Gly Ala Lys Glu Ile Leu Glu Lys Ala Gln Leu
180 185 190Phe
(2) Sequence 659 data: (i) sequence characteristics: length (A): 265bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 212 (D) other information: (xi) Description of the sequence: sequence 659: TAAGCGCTTT GCGTGTTTAA AAATTCCTTA TCCAAGCTCT CAGCGTCTTC ATG AAA 56
Met Lys
1GCT GTA ACC ATC TTT CAT GAT AAA TTC CCT CGC TCT CAC CAG CCC AAA 104Ala Val Thr Ile Phe His Asp Lys Phe Pro Arg Ser His Gln Pro Lys
5 10 15TCT TGG GCG GAT TTC ATC ACG GAA TTT CGT GTG GAT TTG ATA GAG ATG 152Ser Trp Ala Asp Phe Ile Thr Glu Phe Arg Val Asp Leu Ile Glu Met
202530 GAC GGG CAA TTG CTT GTA ACT TTT AAT GAA ATT AGC GGC AAT TTC GGT 200Asp Gly Gln Leu Leu Val Thr Phe Asn Glu Ile Ser Gly Asn Phe Gly 35404550 GAT ATT TTC TTC TAAAGTGGGG CTTAAAACAA AATCATTGTC TTTTCGGTCT TTAAA 257Asp Ile Phe PheAACCAATA 265(2) sequence 660 data:
(i) sequence characteristics:
(A) length: 54 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 660: met Lys Ala Val Thr Ile Phe His Asp Lys Phe Pro Arg Ser His Gln 151015 Pro Lys Ser Trp Ala Asp Phe Ile Thr Glu Phe Arg Val Asp Leu Ile
20 25 30Glu Met Asp Gly Gln Leu Leu Val Thr Phe Asn Glu Ile Ser Gly Asn
35 40 45Phe Gly Asp Ile Phe Phe
50
(2) Sequence 661 data:
(i) sequence characteristics:
(A) length: 1350bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 73...1305
(D) Other information:
(xi) Description of the sequence: sequence 661: TTTTACTTTT TTTTTGGTAT TCTAACAAGC TTTTAAATAA TCCAATCTAC TTTGTTTTAA 60GGATAATATT TT ATG GCA GAT GTC GTT GTG GGG ATC CAG TGG GGA GAT GAG 111
Met Ala Asp Val Val Val Gly Ile Gln Trp Gly Asp Glu
1 5 10GGG AAG GGA AAA ATT GTT GAT AGG ATC GCT AAA GAT TAT GAC TTT GTG 159Gly Lys Gly Lys Ile Val Asp Arg Ile Ala Lys Asp Tyr Asp Phe Val
15 20 25GTG CGC TAT CAG GGC GGG CAT AAT GCT GGG CAT ACC ATT GTG CAT AAG 207Val Arg Tyr Gln Gly Gly His Asn Ala Gly His Thr Ile Val His Lys30 35 40 45GGG GTT AAG CAT TCT TTG CAT TTA ATG CCT TCAGGG GTT TTA TAC CCC 255Gly Val Lys His Ser Leu His Leu Met Pro Ser Gly Val Leu Tyr Pro
50 55 60AAA TGC AAG AAC ATC ATT TCT AGC GCG GTG GTC GTG AGC GTT AAG GAT 303Lys Cys Lys Asn Ile Ile Ser Ser Ala Val Val Val Ser Val Lys Asp
65 70 75TTG TGC GAA GAA ATC AGC GCG TTT GAG GAT TTA GAA AAT CGT TTG TTT 351Leu Cys Glu Glu Ile Ser Ala Phe Glu Asp Leu Glu Asn Arg Leu Phe
80 85 90GTC AGC GAC AGA GCC CAT GTG ATC TTG CCC TAT CAT GCC AAA AAA GAC 399Val Ser Asp Arg Ala His Val Ile Leu Pro Tyr His Ala Lys Lys Asp
95 100 105GCT TTT AAA GAA AAA TCT CAA AAC ATC GGC ACG ACT AAA AAA GGC ATA 447Ala Phe Lys Glu Lys Ser Gln Asn Ile Gly Thr Thr Lys Lys Gly Ile110 115 120 125GGC CCT TGC TAT GAG GAT AAA ATG GCC AGG AGC GGG ATA AGA ATG GGG 495Gly Pro Cys Tyr Glu Asp Lys Met Ala Arg Ser Gly Ile Arg Met Gly
130 135 140GAT TTA TTA GAC GAT AAA ATC TTA GAA GAA AAG CTA AAC GCT CAT TTC 543Asp Leu Leu Asp Asp Lys Ile Leu Glu Glu Lys Leu Asn Ala His Phe
145 150 155AAA GCC ATT GAG CCT TTT AAA AAA GCG TAT GAT TTG GGC GAG AAT TAC 591Lys Ala Ile Glu Pro Phe Lys Lys Ala Tyr Asp Leu Gly Glu Asn Tyr
160 165 170GAA AAA GAT TTG ATG GGG TAT TTT AAA ACT TAC GCT CCA AAA ATT TGC 639Glu Lys Asp Leu Met Gly Tyr Phe Lys Thr Tyr Ala Pro Lys Ile Cys
175 180 185CCC TTT ATC AAA GAC ACG ACA AGC ATG CTG ATA GAA GCG AAT CAA AAG 687Pro Phe Ile Lys Asp Thr Thr SerMet Leu Ile Glu Ala Asn Gln Lys190 195 200 205GGT GAA AAA ATC CTA TTA GAA GGG GCA CAA GGC ACG CTT TTA GAC ATT 735Gly Glu Lys Ile Leu Leu Glu Gly Ala Gln Gly Thr Leu Leu Asp Ile
210 215 220GAT TTA GGG ACT TAC CCT TTT GTA ACA AGC TCT AAC ACC ACG AGC GCT 783Asp Leu Gly Thr Tyr Pro Phe Val Thr Ser Ser Asn Thr Thr Ser Ala
225 230 235AGC GCA TGC GTG AGC ACC GGC TTA AAC CCT AAA GCG ATC AAT GAA GTC 831Ser Ala Cys Val Ser Thr Gly Leu Asn Pro Lys Ala Ile Asn Glu Val
240 245 250ATA GGT ATC ACA AAA GCC TAC TCC ACT CGT GTG GGT AAT GGG CCT TTC 879Ile Gly Ile Thr Lys Ala Tyr Ser Thr Arg Val Gly Asn Gly Pro Phe
255 260 265CCT AGC GAA GAC ACT ACA CCC ATG GGC GAT CAT TTA AGG ACT AAG GGT 927Pro Ser Glu Asp Thr Thr Pro Met Gly Asp His Leu Arg Thr Lys Gly270 275 280 285GCG GAG TTT GGC ACG ACA ACC AAG CGC CCA AGG CGT TGC GGG TGG CTG 975Ala Glu Phe Gly Thr Thr Thr Lys Arg Pro Arg Arg Cys Gly Trp Leu
290 295 300GAT TTG GTG GCT TTG AAA TAC GCT TGC GCT TTG AAT GGT TGC ACG CAA 1023Asp Leu Val Ala Leu Lys Tyr Ala Cys Ala Leu Asn Gly Cys Thr Gln
305 310 315TTA GCC TTA ATG AAA TTA GAC GTT TTA GAC GGG ATT GAT GCG ATT AAG 1071Leu Ala Leu Met Lys Leu Asp Val Leu Asp Gly Ile Asp Ala Ile Lys
320 325 330GTG TGC GTG GCT TAT GAA AGA AAG GGC GAA AGA TTG GAG ATT TTC CCT 1119Val Cys Val Ala Tyr Glu Arg Lys Gly Glu Arg Leu Glu Ile Phe Pro
335 340345AGC GAT TTG AAA GAT TGC GTG CCG ATC TAT CAA ACT TTT AAA GGT TGG 1167Ser Asp Leu Lys Asp Cys Cal Pro Ile Tyr Gln Thr Phe Lys Gly Trp350 355 360 365GAA AAA AGC GTG GGC GTG AGA AAA TTA GAC GAT TTA GAG CCA AAC GTT 1215Glu Lys Ser Val Gly Val Arg Lys Leu Asp Asp Leu Glu Pro Asn Val
370 375 380AGA GAG TAT ATC CGT TTT ATT GAA AAA GAA GTG GGG GTA AAA ATC CGC 1263Arg Glu Tyr Ile Arg Phe Ile Glu Lys Glu Val Gly Val Lys Ile Arg
385 390 395CTT ATT TCT ACA AGC CCT GAA AGA GAA GAC ACG ATT TTT CTA TGAAAAAAT 1314Leu Ile Ser Thr Ser Pro Glu Arg Glu Asp Thr Ile Phe Leu
400 405 410TCGCTTCTGT ATTGGTGCAA TTAAAAACCC TTGCGT 1350
(2) Sequence 662 data: (i) sequence characteristics: length (A): 411 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 662: met Ala Asp Val Val Val Gly Ile Gln Trp Gly Asp Glu Gly Lys Gly 151015 Lys Ile Val Asp Arg Ile Ala Lys Asp Tyr Asp Phe Val Val Arg Tyr
20 25 30Gln Gly Gly His Asn Ala Gly His Thr Ile Val His Lys Gly Val Lys
35 40 45His Ser Leu His Leu Met Pro Ser Gly Val Leu Tyr Pro Lys Cys Lys
50 55 60Asn Ile Ile Ser Ser Ala Val Val Val Ser Val Lys Asp Leu Cys Glu65 70 75 80Glu Ile Ser Ala Phe Glu Asp Leu Glu Asn Arg Leu Phe Val Ser Asp
85 90 95Arg AlaHis Val Ile Leu Pro Tyr His Ala Lys Lys Asp Ala Phe Lys
100 105 1l0Glu Lys Ser Gln Asn Ile Gly Thr Thr Lys Lys Gly Ile Gly Pro Cys
115 120 125Tyr Glu Asp Lys Met Ala Arg Ser Gly Ile Arg Met Gly Asp Leu Leu
130 135 140Asp Asp Lys Ile Leu Glu Glu Lys Leu Asn Ala His Phe Lys Ala Ile145 150 155 160Glu Pro Phe Lys Lys Ala Tyr Asp Leu Gly Glu Asn Tyr Glu Lys Asp
165 170 175Leu Met Gly Tyr Phe Lys Thr Tyr Ala Pro Lys Ile Cys Pro Phe Ile
180 185 190Lys Asp Thr Thr Ser Met Leu Ile Glu Ala Asn Gln Lys Gly Glu Lys
195 200 205Ile Leu Leu Glu Gly Ala Gln Gly Thr Leu Leu Asp Ile Asp Leu Gly
210 215 220Thr Tyr Pro Phe Val Thr Ser Ser Asn Thr Thr Ser Ala Ser Ala Cys225 230 235 240Val Ser Thr Gly Leu Asn Pro Lys Ala Ile Asn Glu Val Ile Gly Ile
245 250 255Thr Lys Ala Tyr Ser Thr Arg Val Gly Asn Gly Pro Phe Pro Ser Glu
260 265 270Asp Thr Thr Pro Met Gly Asp His Leu Arg Thr Lys Gly Ala Glu Phe
275 280 285Gly Thr Thr Thr Lys Arg Pro Arg Arg Cys Gly Trp Leu Asp Leu Val
290 295 300Ala Leu Lys Tyr Ala Cys Ala Leu Asn Gly Cys Thr Gln Leu Ala Leu305 310 315 320Met Lys Leu Asp Val Leu Asp Gly Ile Asp Ala Ile Lys Val Cys Val
325 330 335Ala Tyr Glu Arg Lys Gly Glu Arg Leu Glu Ile Phe Pro Ser Asp Leu
340 345 350Lys Asp Cys Val Pro Ile Tyr Gln Thr Phe Lys Gly Trp Glu Lys Ser
355 360 365Val Gly Val Arg Lys Leu Asp Asp Leu Glu Pro Asn Val Arg Glu Tyr
370 375 380Ile Arg Phe Ile Glu Lys Glu Val Gly Val Lys Ile Arg Leu Ile Ser385 390 395 400Thr Ser Pro Glu Arg Glu Asp Thr Ile Phe Leu
405 410
(2) Sequence 663 data: (i) sequence characteristics: length (A): 1363bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1310 (D) other information: (xi) Description of the sequence: sequence 663: TTTTAGGGCT TTTCAATGAT CTCACTCGTT TGCTATAAAA GGGGGAGCTG GTG GAT 56
Val Asp
1GTA TTG AGC GTG AGC GAA ATC AAT GCG CAA ATC AAA GCC CTT TTA GAA 104Val Leu Ser Val Ser Glu Ile Asn Ala Gln Ile Lys Ala Leu Leu Glu
5 10 15GCG ACT TTT TTG CAA GTT AGG GTT CAA GGG GAA GTG AGT AAT TTG ACT 152Ala Thr Phe Leu Gln Val Arg Val Gln Gly Glu Val Ser Asn Leu Thr
20 25 30ATC CAT AAG GTG AGC GGC CAT GCG TAT TTT TCG CTC AAA GAC AGC CAG 200Ile His Lys Val Ser Gly His Ala Tyr Phe Ser Leu Lys Asp Ser Gln3540 45 50TCG GTT ATT AAA TGC GTG CTG TTT AAA GGG AAC GCT AAC AGG CTC AAA 248Ser Val Ile Lys Cys Val Leu Phe Lys Gly Asn Ala Asn Arg Leu Lys
55 60 65TTC GCT TTA AAA GAA GGG CAG GAA GTG GTT GTT TTT GGG GGT ATT AGC 296Phe Ala Leu Lys Glu Gly Gln Glu Val Val Val Phe Gly Gly Ile Ser
70 75 80GTG TAT GTC CCA AGG GGG GAT TAT CAA ATC AAT TGC TTT GAA ATA GAG 344Val Tyr Val Pro Arg Gly Asp Tyr Gln Ile Asn Cys Phe Glu Ile Glu
85 90 95CCT AAG GAT ATA GGT TCA TTA ACT TTA GCT TTA GAG CAA TTG AAA GAA 392Pro Lys Asp Ile Gly Ser Leu Thr Leu Ala Leu Glu Gln Leu Lys Glu
100 105 110AAA TTA CGC CTT AAA GGC TAT TTT GAT GAA GAA AAT AAA TTA CCC AAA 440Lys Leu Arg Leu Lys Gly Tyr Phe Asp Glu Glu Asn Lys Leu Pro Lys115 120 125 130CCG CAT TTT CCT AAA CGA GTG GCA GTC ATC ACT TCT CAA AAT TCA GCC 488Pro His Phe Pro Lys Arg Val Ala Val Ile Thr Ser Gln Asn Ser Ala
135 140 145GCT TGG GCG GAC ATG AAA AAG ATC GCT TCC AAA CGA TGG CCG ATG TGT 536Ala Trp Ala Asp Met Lys Lys Ile Ala Ser Lys Arg Trp Pro Met Cys
150 155 160GAA TTA GTT TGT ATC AAC ACC TTA ATG CAA GGG GAG GGC TGC GTT CAA 584Glu Leu Val Cys Ile Asn Thr Leu Met Gln Gly Glu Gly Cys Val Gln
165 170 175AGC GTG GTG GAA AGC ATC GTT TAT GCG GAT AGT TTT CAT GAC ACA AAA 632Ser Val Val Glu Ser Ile Val Tyr Ala Asp Ser Phe His Asp Thr Lys
180 185 190AAC GCT TTT GAT GCG ATT GTA GTG GCT AGG GGT GGG GGG AGC ATG GAG 680Asn Ala Phe Asp Ala Ile Val Val Ala Arg Gly Gly Gly Ser Met Glu195 200 205 210GAT TTG TAT TCT TTC AAT GAT GAA AAA ATC GCT GAT GCT CTG TAT TTG 728Asp Leu Tyr Ser Phe Asn Asp Glu Lys Ile Ala Asp Ala Leu Tyr Leu
215 220 225GCC AAA ACC TTC AGC ATG TCA GCT ATT GGG CAT GAG AGC GAT TTT TTA 776Ala Lys Thr Phe Ser Met Ser Ala Ile Gly His Glu Ser Asp Phe Leu
230 235 240TTG AGC GAT TTA GTG GCG GAT TTA AGG GCT TCT ACG CCT TCA AAC GCG 824Leu Ser Asp Leu Val Ala Asp Leu Arg Ala Ser Thr Pro Ser Asn Ala
245 250 255ATG GAA ATT TTA CTC CCC AGC AGC GAT GAA TGG TTG CAA AGA CTT GAT 872Met Glu Ile Leu Leu Pro Ser Ser Asp Glu Trp Leu Gln Arg Leu Asp
260 265 270GGG TTT AAT GTG AAA TTG CAC CGC TCG TTT AAA ACT TTG CTC CAC CAA 920Gly Phe Asn Val Lys Leu His Arg Ser Phe Lys Thr Leu Leu His Gln275 280 285 290AAA AAG GCG CAT TTA GAG CAT TTA GTG GCT TCT TTA AAA CGA TTG AGT 968Lys Lys Ala His Leu Glu His Leu Val Ala Ser Leu Lys Arg Leu Ser
295 300 305TTT GAA AAC AAG CAC CAT TTA AAC GCT TTA AAA CTA GAA AAA TTA AAA 1016Phe Glu Asn Lys His His Leu Asn Ala Leu Lys Leu Glu Lys Leu Lys
310 315 320ATC GCC CTA GAA AAT AAA ACT CTA GAA TTT TTA CGC TTT AAA AAA ACG 1064Ile Ala Leu Glu Asn Lys Thr Leu Glu Phe Leu Arg Phe Lys Lys Thr
325 330 335CTT TTA GAA AAA ATC TCT ACT CAA ACA TTA ACA AGC CCT TTT TTA CAA 1112LeuLeu Glu Lys Ile Ser Thr Gln Thr Leu Thr Ser Pro Phe Leu Gln
340 345 350ACT AAA ACA GAG CGA TTG AAC AGG CTA GAA AAC GCC CTT AAA CTC GCT 1160Thr Lys Thr Glu Arg Leu Asn Arg Leu Glu Asn Ala Leu Lys Leu Ala355 360 365 370CAT GCT AAT TTG AAA TTA CCC CAA TTC GGG GCG TTG GTG AGC AAA AAT 1208His Ala Asn Leu Lys Leu Pro Gln Phe Gly Ala Leu Val Ser Lys Asn
375 380 385AAT CAA GCG ATA GAA TTA GAG GCA TTA AAA AGG GGC GAT AAA ATT GAA 1256Asn Gln Ala Ile Glu Leu Glu Ala Leu Lys Arg Gly Asp Lys Ile Glu
390 395 400TTA AGT AAT GAA AAA ACC AGA GCG AGC GCT GAA ATT TTG AGC GTG GAT 1304Leu Ser Asn Glu Lys Thr Arg Ala Ser Ala Glu Ile Leu Ser Val Asp
405 410 415AGG GTG TAGGGGTTTG AAAAATAATA TTTAAAACGC TATTTGTTTT ATCTTAAAAT TT 1362Arg Val
420
1363
(2) Sequence 664 data: (i) sequence characteristics: length (A): 420 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 664: val Asp Val Leu Ser Val Ser Glu Ile Asn Ala Gln Ile Lys Ala Leu 151015 Leu Glu Ala Thr Phe Leu Gln Val Arg Val Gln Gly Glu Val Ser Asn
20 25 30Leu Thr Ile His Lys Val Ser Gly His Ala Tyr Phe Ser Leu Lys Asp
35 40 45Ser Gln Ser Val Ile Lys Cys Val Leu Phe Lys Gly Asn Ala Asn Arg
50 5560Leu Lys Phe Ala Leu Lys Glu Gly Gln Glu Val Val Val Phe Gly Gly65 70 75 80Ile Ser Val Tyr Val Pro Arg Gly Asp Tyr Gln Ile Asn Cys Phe Glu
85 90 95Ile Glu Pro Lys Asp Ile Gly Ser Leu Thr Leu Ala Leu Glu Gln Leu
100 105 110Lys Glu Lys Leu Arg Leu Lys Gly Tyr Phe Asp Glu Glu Asn Lys Leu
115 120 125Pro Lys Pro His Phe Pro Lys Arg Val Ala Val Ile Thr Ser Gln Asn
130 135 140Ser Ala Ala Trp Ala Asp Met Lys Lys Ile Ala Ser Lys Arg Trp Pro145 150 155 160Met Cys Glu Leu Val Cys Ile Asn Thr Leu Met Gln Gly Glu Gly Cys
165 170 175Val Gln Ser Val Val Glu Ser Ile Val Tyr Ala Asp Ser Phe His Asp
180 185 190Thr Lys Asn Ala Phe Asp Ala Ile Val Val Ala Arg Gly Gly Gly Ser
195 200 205Met Glu Asp Leu Tyr Ser Phe Asn Asp Glu Lys Ile Ala Asp Ala Leu
210 215 220Tyr Leu Ala Lys Thr Phe Ser Met Ser Ala Ile Gly His Glu Ser Asp225 230 235 240Phe Leu Leu Ser Asp Leu Val Ala Asp Leu Arg Ala Ser Thr Pro Ser
245 250 255Asn Ala Met Glu Ile Leu Leu Pro Ser Ser Asp Glu Trp Leu Gln Arg
260 265 270Leu Asp Gly Phe Asn Val Lys Leu His Arg Ser Phe Lys Thr Leu Leu
275 280 285His Gln Lys Lys Ala His Leu Glu His Leu Val Ala Ser Leu Lys Arg
290 295 300Leu Ser Phe Glu Asn Lys His His Leu Asn Ala Leu Lys Leu Glu Lys305 310 315 320Leu Lys Ile Ala Leu Glu Asn Lys Thr Leu Glu Phe Leu Arg Phe Lys
325 330 335Lys Thr Leu Leu Glu Lys Ile Ser Thr Gln Thr Leu Thr Ser Pro Phe
340 345 350Leu Gln Thr Lys Thr Glu Arg Leu Asn Arg Leu Glu Asn Ala Leu Lys
355 360 365Leu Ala His Ala Asn Leu Lys Leu Pro Gln Phe Gly Ala Leu Val Ser
370 375 380Lys Asn Asn Gln Ala Ile Glu Leu Glu Ala Leu Lys Arg Gly Asp Lys385 390 395 400Ile Glu Leu Ser Asn Glu Lys Thr Arg Ala Ser Ala Glu Ile Leu Ser
405 410 415Val Asp Arg Val
420
(2) Sequence 665 data: (i) sequence characteristics: length (A): 1083bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1031 (D) other information: (xi) Description of the sequence: sequence 665: AAAGACGCGC ATGGATTCTG TTGGGTTTGA AGAACCTCAA AGGGGTTTGG GTG CTT 56
Val Leu
1AAG GGG TTA AAA AAA GCG TTT AAG GAG AGG TTT TGC TCT CAA GTG TAT 104Lys Gly Leu Lys Lys Ala Phe Lys Glu Arg Phe Cys Ser Gln Val Tyr
5 1015ATC TCT TTT AAT GTG GAT CAC AAT CTT TTA TCC ACT CAA GTC ATA AGG 152Ile Ser Phe Asn Val Asp His Asn Leu Leu Ser Thr Gln Val Ile Arg
20 25 30ATC AAA AAC GAT CGC ATT AAA GAG AAA TTT TTT AAA ACT TTT GAG ACT 200Ile Lys Asn Asp Arg Ile Lys Glu Lys Phe Phe Lys Thr Phe Glu Thr35 40 45 50AAA GTG GAG ACT AAA AAT GGT GAA GTC CCT ATT CAA GCC TTA AAA ATC 248Lys Val Glu Thr Lys Asn Gly Glu Val Pro Ile Gln Ala Leu Lys Ile
55 60 65GCC AGA ACT TAT AGC CAA AAA TAC CCC TAC ACT TAT TTT AGC GCG ATG 296Ala Arg Thr Tyr Ser Gln Lys Tyr Pro Tyr Thr Tyr Phe Ser Ala Met
70 75 80AGT AAA GCT AAA GAG GTT TTA TGC GAA AAG CAG GCG TTT GAA CAA ATC 344Ser Lys Ala Lys Glu Val Leu Cys Glu Lys Gln Ala Phe Glu Gln Ile
85 90 95AAA CAA GAA AAT CAA GAT TAT CAT GCT TGT GAA GTC AAT CAA AAG TAT 392Lys Gln Glu Asn Gln Asp Tyr His Ala Cys Glu Val Asn Gln Lys Tyr
100 105 110TGC GTT TAT GTG GAA TCT AAG GAT TTT TTA AAG GAT TTT AAG CGT TTT 440Cys Val Tyr Val Glu Ser Lys Asp Phe Leu Lys Asp Phe Lys Arg Phe115 120 125 130AAA ATC CAG GAT GTG GAT TTT TTG TTT TCG CCT TTT AGC CTT ATT TAT 488Lys Ile Gln Asp Val Asp Phe Leu Phe Ser Pro Phe Ser Leu Ile Tyr
135 140 145GAT TTT GTG CGC GAT AAT TTA GAA AAT AAG CCG TTG TTG TAT TTG CTT 536Asp Phe Val Arg Asp Asn Leu Glu Asn Lys Pro Leu Leu Tyr Leu Leu
150 155 160TTG GAG CGT TCA AGA TTT TAT TTT TTG ATT GCG GAT AAA AAA GAG ATT 584Leu Glu Arg Ser Arg Phe Tyr Phe Leu Ile Ala Asp Lys Lys Glu Ile
165 170 175TTT TTA GCC AAA TCC GTG TTT TTA GAA GAA CAA CCT GAA GAG TTT ATA 632Phe Leu Ala Lys Ser Val Phe Leu Glu Glu Gln Pro Glu Glu Phe Ile
180 185 190GAG AGC AAA GAA GAA GAT TTT ATG GGA ATG GAT AAT GAG GCT GTG GAT 680Glu Ser Lys Glu Glu Asp Phe Met Gly Met Asp Asn Glu Ala Val Asp195 200 205 210TTG TTT TTG AGT GAA ATC CAA GAA GAT ATT GAC AGC CTT GAA GAA GCG 728Leu Phe Leu Ser Glu Ile Gln Glu Asp Ile Asp Ser Leu Glu Glu Ala
215 220 225ATA GGC CTA GAC AGC AGT AAG GAT AAT AGC GAA AAA ATA ACA GAG GAC 776Ile Gly Leu Asp Ser Ser Lys Asp Asn Ser Glu Lys Ile Thr Glu Asp
230 235 240GCT TAT AGT TTG ATT GAA GGC ATG ACG AAT ATC CCC TTA ATT GCA GAT 824Ala Tyr Ser Leu Ile Glu Gly Met Thr Asn Ile Pro Leu Ile Ala Asp
245 250 255GTT TTG CAA GAG GGA TTG CGT GGC GTC TAT CAT TCT AGA GAG ATA GAC 872Val Leu Gln Glu Gly Leu Arg Gly Val Tyr His Ser Arg Glu Ile Asp
260 265 270TTT GTA GAA AAA GTG GTT GTT TTA GAC AGC TGT CAA ATC CAC CAA AAA 920Phe Val Glu Lys Val Val Val Leu Asp Ser Cys Gln Ile His Gln Lys275 280 285 290GCG TTA ATG CAT TTG CAA GAA ACT TTG ATG ATA GAA GTG GAT AGG CTT 968Ala Leu Met His Leu Gln Glu Thr Leu Met Ile Glu Val Asp Arg Leu
295 300 305GAT TTT TCT TTA GTG GAG CGC TTG AAC ATT TTA GCG CGC ATG GAG AAT 1016Asp Phe Ser Leu Val Glu Arg Leu Asn Ile Leu Ala Arg Met Glu Asn
310 315 320GAA AAG CAT GCG TTT TAGTTACATT GAGCCAAGAG CGAAATACCT TATCAGCAAG C 1072Glu Lys His Ala Phe
325TTTCTAAAAT T 1083
(2) Sequence 666 data: (i) sequence characteristics: length (A): 327 amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (v) fragment type: internal (xi) sequence description: sequence 666: val Leu Lys Gly Leu Lys Lys Ala Phe Lys Glu Arg Phe Cys Ser Gln 151015 Val Tyr Ile Ser Phe Asn Val Asp His Asn Leu Leu Ser Thr Gln Val
20 25 30Ile Arg Ile Lys Asn Asp Arg Ile Lys Glu Lys Phe Phe Lys Thr Phe
35 40 45Glu Thr Lys Val Glu Thr Lys Asn Gly Glu Val Pro Ile Gln Ala Leu
50 55 60Lys Ile Ala Arg Thr Tyr Ser Gln Lys Tyr Pro Tyr Thr Tyr Phe Ser65 70 75 80Ala Met Ser Lys Ala Lys Glu Val Leu Cys Glu Lys Gln Ala Phe Glu
85 90 95Gln Ile Lys Gln Glu Asn Gln Asp Tyr His Ala Cys Glu Val Asn Gln
100 105 110Lys Tyr Cys Val Tyr Val Glu Ser Lys Asp Phe Leu Lys Asp Phe Lys
115 120 125Arg Phe Lys Ile Gln Asp Val Asp Phe Leu Phe Ser Pro Phe Ser Leu
130 135 140Ile Tyr Asp Phe Val Arg Asp Asn Leu Glu Asn Lys Pro Leu Leu Tyr145 150 155 160Leu Leu Leu Glu Arg Ser Arg Phe Tyr Phe Leu Ile Ala Asp Lys Lys
165 170 175Glu Ile Phe Leu Ala Lys Ser Val Phe Leu Glu Glu Gln Pro Glu Glu
180 185 190Phe Ile Glu Ser Lys Glu Glu Asp Phe Met Gly Met Asp Asn Glu Ala
195 200 205Val Asp Leu Phe Leu Ser Glu Ile Gln Glu Asp Ile Asp Ser Leu Glu
210 215 220Glu Ala Ile Gly Leu Asp Ser Ser Lys Asp Asn Ser Glu Lys Ile Thr225 230 235 240Glu Asp Ala Tyr Ser Leu Ile Glu Gly Met Thr Asn Ile Pro Leu Ile
245 250 255Ala Asp Val Leu Gln Glu Gly Leu Arg Gly Val Tyr His Ser Arg Glu
260 265 270Ile Asp Phe Val Glu Lys Val Val Val Leu Asp Ser Cys Gln Ile His
275 280 285Gln Lys Ala Leu Met His Leu Gln Glu Thr Leu Met Ile Glu Val Asp
290 295 300Arg Leu Asp Phe Ser Leu Val Glu Arg Leu Asn Ile Leu Ala Arg Met305 310 315 320Glu Asn Glu Lys His Ala Phe
325
(2) Sequence 667 data:
(i) sequence characteristics:
(A) length: 1233bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 58...1170
(D) Other information:
(xi) Description of the sequence: sequence 667: ATTCCAAACT TCCTAAAAAA TGATTACGCC ATTATATCCA AGATTAAGGC TTAAACG ATG 60
Met
1GAT TTT CAA CTC CAA GCG ACT GAC AAT AAC GCG CGA GCT GGT CTT TTA 108Asp Phe Gln Leu Gln Ala Thr Asp Asn Asn Ala Arg Ala Gly Leu Leu
5 10 15AAT TTA GCC CAT TCT CAA GTG GCA ACG CCT GTT TTT ATG CCC GTA GGC 156Asn Leu Ala His Ser Gln Val Ala Thr Pro Val Phe Met Pro Val Gly
20 25 30ACG CAA GGC TGC ATC AAA TCT TTA GAC GCT ACA GAT GCG CAA GAA ATT 204Thr Gln Gly Cys Ile Lys Ser Leu Asp Ala Thr Asp Ala Gln Glu Ile
35 40 45TTA GGC GCT AAA CTC ATT TTA GCC AAC ACC TAT CAC ATG TAT TTA AGG 252Leu Gly Ala Lys Leu Ile Leu Ala Asn Thr Tyr His Met Tyr Leu Arg50 55 60 65CCG GGT GAA AAG GTC GTT GAG GAG TTA GGG GGC TTG CAT CGT TTC GCT 300Pro Gly Glu Lys Val Val Glu Glu Leu Gly Gly Leu His Arg Phe Ala
70 75 80CAA TTT TAT GGG AGT TTT TTA ACC GAT AGT GGA GGG TTT CAA GCC TTT 348Gln Phe Tyr Gly Ser Phe Leu Thr Asp Ser Gly Gly Phe Gln Ala Phe
85 90 95AGT TTG AGC GAT AAT GTC AAA TTG CAA GAA GAT GGG ATC GTT TTT AAA 396Ser Leu Ser Asp Asn Val Lys Leu Gln Glu Asp Gly Ile Val Phe Lys
100 105 110TCC CAT ATT GAT GGG AGC AAGCAT CTA TTC ACG CCC GCT AAA GTT TTG 444Ser His Ile Asp Gly Ser Lys His Leu Phe Thr Pro Ala Lys Val Leu
115 120 125GAC ATT CAA TAT TCT TTG AAT AGC GAT ATT ATG ATG GTT TTA GAC GAT 492Asp Ile Gln Tyr Ser Leu Asn Ser Asp Ile Met Met Val Leu Asp Asp130 135 140 145TTA GTG GGC TTG CCC GCT CCC TTA AAA CGC CTT GAA GAA TCC ATT AAA 540Leu Val Gly Leu Pro Ala Pro Leu Lys Arg Leu Glu Glu Ser Ile Lys
150 155 160AGA AGT GCT AAA TGG GCG AAT ATG AGC CTA GAA TAC CAC AAA GAA AAA 588Arg Ser Ala Lys Trp Ala Asn Met Ser Leu Glu Tyr His Lys Glu Lys
165 170 175AAC CGC CCG AGC AAC AAC CTT TTT GCC ATT ATC CAG GGC GGG ACG CAT 636Asn Arg Pro Ser Asn Asn Leu Phe Ala Ile Ile Gln Gly Gly Thr His
180 185 190TTG AAA ATG CGC AGC CTT AGC GTG GGA TTA ACG CAT GAG GGT TTT GAT 684Leu Lys Met Arg Ser Leu Ser Val Gly Leu Thr His Glu Gly Phe Asp
195 200 205GGC TAC GCT ATA GGC GGT TTA GCG GTG GGG GAA AGC GCT GAT GAA ATG 732Gly Tyr Ala Ile Gly Gly Leu Ala Val Gly Glu Ser Ala Asp Glu Met210 215 220 225CTA GAA ACC ATC GCG CAC ACC GCC CCC TTG CTC CCC AAA GAC AAG CCT 780Leu Glu Thr Ile Ala His Thr Ala Pro Leu Leu Pro Lys Asp Lys Pro
230 235 240CGC TAC TTA ATG GGC GTA GGC ACG CCT GAA AAT ATC CTA GAC GCT ATC 828Arg Tyr Leu Met Gly Val Gly Thr Pro Glu Asn Ile Leu Asp Ala Ile
245 250 255AGT TTG GGG GTG GAT ATG TTT GAT TGC GTG ATG CCC ACC AGA AAC GCC 876Ser Leu Gly Val Asp Met Phe Asp CysVal Met Pro Thr Arg Asn Ala
260 265 270AGA AAC GCC ACC CTT TTC ACG CAT TCT GGC AAA ATT TCT ATC AAA AAC 924Arg Asn Ala Thr Leu Phe Thr His Ser Gly Lys Ile Ser Ile Lys Asn
275 280 285GCG CCC TAT AAA TTG GAT AAT ACC CCT ATT GAA GAA AAT TGC GCA TGT 972Ala Pro Tyr Lys Leu Asp Asn Thr Pro Ile Glu Glu Asn Cys Ala Cys290 295 300 305TAT GCT TGC AAA CGC TAT TCT AAA GCC TAT TTG CAC CAT TTA TTT AGG 1020Tyr Ala Cys Lys Arg Tyr Ser Lys Ala Tyr Leu His His Leu Phe Arg
310 315 320GCT AAA GAA CTC ACT TAC GCT CGT TTG GCC AGC TTG CAC AAT TTG CAT 1068Ala Lys Glu Leu Thr Tyr Ala Arg Leu Ala Ser Leu His Asn Leu His
325 330 335TTT TAT TTA GAG CTG GTG AAG AAC GCC AGA AAC GCC ATT TTA GAA AAG 1116Phe Tyr Leu Glu Leu Val Lys Asn Ala Arg Asn Ala Ile Leu Glu Lys
340 345 350CGG TTT TTG AGT TTT AAA AAA GAA TTT TTG GAG AAA TAC AAC TCC CGC 1164Arg Phe Leu Ser Phe Lys Lys Glu Phe Leu Glu Lys Tyr Asn Ser Arg
355 360 365TCT CAT TGAATGATGG AATGCAAAAA TACTAAAAAG CGTTTTTTAC CATCAATAAA AG 1222Ser His370TTTTCTTAAA A 1233
(2) Sequence 668 data:
(i) sequence characteristics:
(A) length: 371 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 668: met Asp Phe Gln Leu Gln Ala Thr Asp Asn Asn Ala Arg Ala Gly Leu 151015 Leu Asn Leu Ala His Ser Gln Val Ala Thr Pro Val Phe Met Pro Val
20 25 30Gly Thr Gln Gly Cys Ile Lys Ser Leu Asp Ala Thr Asp Ala Gln Glu
35 40 45Ile Leu Gly Ala Lys Leu Ile Leu Ala Ash Thr Tyr His Met Tyr Leu
50 55 60Arg Pro Gly Glu Lys Val Val Glu Glu Leu Gly Gly Leu His Arg Phe65 70 75 80Ala Gln Phe Tyr Gly Ser Phe Leu Thr Asp Ser Gly Gly Phe Gln Ala
85 90 95Phe Ser Leu Ser Asp Asn Val Lys Leu Gln Glu Asp Gly Ile Val Phe
100 105 110Lys Ser His Ile Asp Gly Ser Lys His Leu Phe Thr Pro Ala Lys Val
115 120 125Leu Asp Ile Gln Tyr Ser Leu Asn Ser Asp Ile Met Met Val Leu Asp
130 135 140Asp Leu Val Gly Leu Pro Ala Pro Leu Lys Arg Leu Glu Glu Ser Ile145 150 155 160Lys Arg Ser Ala Lys Trp Ala Asn Met Ser Leu Glu Tyr His Lys Glu
165 170 175Lys Asn Arg Pro Ser Asn Asn Leu Phe Ala Ile Ile Gln Gly Gly Thr
180 185 190His Leu Lys Met Arg Ser Leu Ser Val Gly Leu Thr His Glu Gly Phe
195 200 205Asp Gly Tyr Ala Ile Gly Gly Leu Ala Val Gly Glu Ser Ala Asp Glu
210 215 220Met Leu Glu Thr Ile Ala His Thr Ala Pro Leu Leu Pro Lys Asp Lys225 230 235 240Pro Arg Tyr Leu Met Gly Val Gly Thr Pro Glu Asn Ile Leu Asp Ala
245 250 255Ile Ser Leu Gly Val Asp Met Phe Asp Cys Val Met Pro Thr Arg Asn
260 265 270Ala Arg Asn Ala Thr Leu Phe Thr His Ser Gly Lys Ile Ser Ile Lys
275 280 285Asn Ala Pro Tyr Lys Leu Asp Asn Thr Pro Ile Glu Glu Asn Cys Ala
290 295 300Cys Tyr Ala Cys Lys Arg Tyr Ser Lys Ala Tyr Leu His His Leu Phe305 310 315 320Arg Ala Lys Glu Leu Thr Tyr Ala Arg Leu Ala Ser Leu His Asn Leu
325 330 335His Phe Tyr Leu Glu Leu Val Lys Asn Ala Arg Asn Ala Ile Leu Glu
340 345 350Lys Arg Phe Leu Ser Phe Lys Lys Glu Phe Leu Glu Lys Tyr Asn Ser
355 360 365Arg Ser His
370
(2) Sequence 669 data:
(i) sequence characteristics:
(A) length: 1357 bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1304
(D) Other information:
(xi) Description of the sequence: sequence 669: GTGGATGCTG ATTTTTTAGG CGATGGTTTT GGGAATAAAA GGGAACAAAA ATG AAA 56
Met Lys
1AAA GTC TAT TTC AAA ACT TTT GGG TGC AGG ACG AAT CTT TTT GAC ACG 104Lys Val Tyr Phe Lys Thr Phe Gly Cys Arg Thr Asn Leu Phe Asp Thr
5 10 15CAA GTG ATG AGC GAG AAT TTG AAG GAC TTT AGC ACG ACC TTA GAA GAA 152Gln Val Met Ser Glu Asn Leu Lys Asp Phe Ser Thr Thr Leu Glu Glu
20 25 30CAA GAA GCC GAT ATT ATT ATC ATC AAT TCT TGC ACC GTG ACC AAT GGG 200Gln Glu Ala Asp Ile Ile Ile Ile Asn Ser Cys Thr Val Thr Asn Gly35 40 45 50GCC GAT AGC GCG GTA AGG AGT TAC GCT AAA AAA ATG GCA CGG TTG GAT 248Ala Asp Ser Ala Val Arg Ser Tyr Ala Lys Lys Met Ala Arg Leu Asp
55 60 65AAG GAA GTG CTA TTT ACT GGT TGC GGG GTG AAA ACC CAA GGC AAA GAG 296Lys Glu Val Leu Phe Thr Gly Cys Gly Val Lys Thr Gln Gly Lys Glu
70 75 80CTT TTT GAA AAA GGG TTT TTA AAG GGC GTT TTT GGG CAT GAC AAT AAA 344Leu Phe Glu Lys Gly Phe Leu Lys Gly Val Phe Gly His Asp Asn Lys
85 90 95GAA AAG ATT AAC GCG CTT TTA CAA GAA AAA AAG CGT TTT TTT ATA GAT 392Glu Lys Ile Asn Ala Leu Leu Gln Glu Lys Lys Arg Phe Phe Ile Asp
100 105 110GAC AAT TTA GAA AAC AAG CAC TTA GAC ACC ACG ATG GTG AGC GAG TTT 440Asp Asn Leu Glu Asn Lys His Leu Asp Thr Thr Met Val Ser Glu Phe115 120 125 130GTG GGA AAA ACT AGG GCG TTT ATT AAG ATC CAA GAA GGC TGT GAT TTT 488Val Gly Lys Thr Arg Ala Phe Ile Lys Ile Gln Glu Gly Cys Asp Phe
135 140 145GAT TGC AAT TAT TGC ATT ATC CCA AGC GTG AGA GGG AGG GCT AGG AGT 536Asp Cys Asn Tyr Cys Ile Ile Pro Ser Val Arg Gly Arg Ala Arg Ser
150 155 160TTT GAA GAG AGA AAA ATT TTA GAG CAA GTG GGC CTT TTA TGC TCT AAA 584Phe Glu Glu Arg Lys Ile Leu Glu Gln Val Gly Leu Leu Cys Ser Lys
165 170 175GGG GTT CAA GAA GTG GTT TTA ACC GGC ACC AAT GTG GGG AGC TAT GGG 632Gly Val Gln Glu Val Val Leu Thr Gly Thr Asn Val Gly Ser Tyr Gly
180 185 190AAA GAT AGA GGA AGC AAT ATC GCG CGA TTG ATT AAA AAA TTA AGC CAG 680Lys Asp Arg Gly Ser Asn Ile Ala Arg Leu Ile Lys Lys Leu Ser Gln195 200 205 210ATC GCT GGA TTA AAA CGC ATA AGG ATT GGG AGC TTA GAA CCT AAT CAA 728Ile Ala Gly Leu Lys Arg Ile Arg Ile Gly Ser Leu Glu Pro Asn Gln
215 220 225ATT AAC GAT GAA TTT TTA GAG CTT TTA GAA GAG GAT TTT TTA GAA AAA 776Ile Asn Asp Glu Phe Leu Glu Leu Leu Glu Glu Asp Phe Leu Glu Lys
230 235 240CAT TTG CAT ATC GCT TTA CAG CAC AGC CAT GAT CTC ATG CTA GAG AGG 824His Leu His Ile Ala Leu Gln His Ser His Asp Leu Met Leu Glu Arg
245 250 255ATG AAT CGA AGA AAC CGC ACT AAA AGC GAT AGG GAA TTA TTA GAA ACA 872Met Asn Arg Arg Asn Arg Thr Lys Ser Asp Arg Glu Leu Leu Glu Thr
260 265 270ATC GCT TCT AAG AAT TTT GCT ATT GGC ACG GAT TTT ATT GTG GGG CAT 920Ile Ala Ser Lys Asn Phe Ala Ile Gly Thr Asp Phe Ile Val Gly His275 280 285 290CCG GGC GAG AGC GGA AGC GTT TTT GAA AAA GCG TTT AAA AAT TTA GAA 968Pro Gly Glu Ser Gly Ser Val Phe Glu Lys Ala Phe Lys Asn Leu Glu
295 300 305AGC TTG CCT TTA ACG CAC ATC CAC CCT TTT ATT TAC AGC AAA CGA AAA 1016Ser Leu Pro Leu Thr His Ile His Pro Phe Ile Tyr Ser Lys Arg Lys
310 315 320GAC ACC CCC TCT AGC TTG ATG ACT GAT AGC GTG AGT TTG GAA GAT TCT 1064Asp Thr Pro Ser Ser Leu Met Thr Asp Ser Val Ser Leu Glu Asp Ser
325 330 335AAA AAG CGT TTG AAT GCG ATT AAA GAT TTG ATT TTT CAT AAA AAT AAG 1112Lys Lys Arg Leu Asn Ala Ile Lys Asp Leu Ile Phe His Lys Asn Lys
340 345 350GCG TTC AGG CAA TTG CAG CTC AAG CTC AAT ACG CCT CTA AAA GCC TTA 1160Ala Phe Arg Gln Leu Gln Leu Lys Leu Asn Thr Pro Leu Lys Ala Leu355 360 365 370GTG GAA GTG CAA AAA GAC GGC GAA TTT AAA GCC TTA GAT CAA TTT TTC 1208Val Glu Val Gln Lys Asp Gly Glu Phe Lys Ala Leu Asp Gln Phe Phe
375 380 385AAC CCC ATT AAA ATC AAA AGC GAT AAG CCT CTA AGG GCT AGT TTT TTA 1256Asn Pro Ile Lys Ile Lys Ser Asp Lys Pro Leu Arg Ala Ser Phe Leu
390 395 400GAA ATC AAA GAG TAT GAA ATT AAG GAG AGG GAA AAT CAT GCC GTT TTC T 1305Glu Ile Lys Glu Tyr Glu Ile Lys Glu Arg Glu Ash His Ala Val Phe
405 410415AAAAATTTAG AAAATCTTAC CGCTCCCTTC AAACGCATTA AAAACCGCTC GC 1357
(2) Sequence 670 data:
(i) sequence characteristics:
(A) length: 418 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 670: met Lys Lys Val Tyr Phe Lys Thr Phe Gly Cys Arg Thr Asn Leu Phe 151015 Asp Thr Gln Val Met Ser Glu Asn Leu Lys Asp Phe Ser Thr Thr Leu
20 25 30Glu Glu Gln Glu Ala Asp Ile Ile Ile Ile Asn Ser Cys Thr Val Thr
35 40 45Asn Gly Ala Asp Ser Ala Val Arg Ser Tyr Ala Lys Lys Met Ala Arg
50 55 60Leu Asp Lys Glu Val Leu Phe Thr Gly Cys Gly Val Lys Thr Gln Gly65 70 75 80Lys Glu Leu Phe Glu Lys Gly Phe Leu Lys Gly Val Phe Gly His Asp
85 90 95Asn Lys Glu Lys He Asn Ala Leu Leu Gln Glu Lys Lys Arg Phe Phe
100 105 110Ile Asp Asp Asn Leu Glu Asn Lys His Leu Asp Thr Thr Met Val Ser
115 120 125Glu Phe Val Gly Lys Thr Arg Ala Phe Ile Lys Ile Gln Glu Gly Cys
130 135 140Asp Phe Asp Cys Asn Tyr Cys Ile Ile Pro Ser Val Arg Gly Arg Ala145 150 155 160Arg Ser Phe Glu Glu Arg Lys Ile Leu Glu Gln Val Gly Leu Leu Cys
165 170 175Ser Lys Gly Val Gln Glu Val Val Leu Thr Gly Thr Asn Val Gly Ser
180 185 190Tyr Gly Lys Asp Arg Gly Ser Asn Ile Ala Arg Leu Ile Lys Lys Leu
195 200 205Ser Gln Ile Ala Gly Leu Lys Arg Ile Arg Ile Gly Ser Leu Glu Pro
210 215 220Asn Gln Ile Asn Asp Glu Phe Leu Glu Leu Leu Glu Glu Asp Phe Leu225 230 235 240Glu Lys His Leu His Ile Ala Leu Gln His Ser His Asp Leu Met Leu
245 250 255Glu Arg Met Asn Arg Arg Asn Arg Thr Lys Ser Asp Arg Glu Leu Leu
260 265 270Glu Thr Ile Ala Ser Lys Asn Phe Ala Ile Gly Thr Asp Phe Ile Val
275 280 285Gly His Pro Gly Glu Ser Gly Ser Val Phe Glu Lys Ala Phe Lys Asn
290 295 300Leu Glu Ser Leu Pro Leu Thr His Ile His Pro Phe Ile Tyr Ser Lys305 310 315 320Arg Lys Asp Thr Pro Ser Ser Leu Met Thr Asp Ser Val Ser Leu Glu
325 330 335Asp Ser Lys Lys Arg Leu Asn Ala Ile Lys Asp Leu Ile Phe His Lys
340 345 350Asn Lys Ala Phe Arg Gln Leu Gln Leu Lys Leu Asn Thr Pro Leu Lys
355 360 365Ala Leu Val Glu Val Gln Lys Asp Gly Glu Phe Lys Ala Leu Asp Gln
370375 380Phe Phe Asn Pro Ile Lys Ile Lys Ser Asp Lys Pro Leu Arg Ala Ser385 390 395 400Phe Leu Glu Ile Lys Glu Tyr Glu Ile Lys Glu Arg Glu Asn His Ala
405 410 415Val Phe
(2) Sequence 671 data:
(i) sequence characteristics:
(A) length: 574 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...521
(D) Other information:
(xi) Description of the sequence: sequence 671: AGTTTAAGGA TTGCAACCAT TTGTTGCAAA AATCTTAAAA AAGGTGGAAG ATG AAA 56
Met Lys
1AAA TTT GGT TTG GGG GTG TAT TTG CTT CTT TTA GGT ATT TTG GGC GGC 104Lys Phe Gly Leu Gly Val Tyr Leu Leu Leu Leu Gly Ile Leu Gly Gly
5 10 15TCT TTG ATC ATT CTA GGA GCG ATA GTC GCG CCC ATT GTT TTC AAA GCT 152Ser Leu Ile Ile Leu Gly Ala Ile Val Ala Pro Ile Val Phe Lys Ala
20 25 30TCA AGC GTT TTA CCT GAA TTG CAT CTG ACT CCC TTT GAG AGC GGG AAA 200Ser Ser Val Leu Pro Glu Leu His Leu Thr Pro Phe Glu Ser Gly Lys35 40 45 50CTC ATG GCG CAAATC TTT GTG CGT TTC AAT TAT GTT TTA GGC GCG ATC 248Leu Met Ala Gln Ile Phe Val Arg Phe Asn Tyr Val Leu Gly Ala Ile
55 60 65GGT TTT GTA GTG TTA CTT TAT GAA ATC ATT TCG TTT ATT TAT TAC AAA 296Gly Phe Val Val Leu Leu Tyr Glu Ile Ile Ser Phe Ile Tyr Tyr Lys
70 75 80AGA TCG TTA GTG TAT TTG ATC CTT GGC GTG GCG ATA GGG GCG TTG TGT 344Arg Ser Leu Val Tyr Leu Ile Leu Gly Val Ala Ile Gly Ala Leu Cys
85 90 95TTG CTC TTT GTT TTT TAT TAC ACG CCT TAT ATT TTA AAC GCT CAA AAA 392Leu Leu Phe Val Phe Tyr Tyr Thr Pro Tyr Ile Leu Asn Ala Gln Lys
100 105 110GCG GGC GAA GCC GCG CTT CAA AGT GCT GAA TTT GCC CGC TCG CAC GCT 440Ala Gly Glu Ala Ala Leu Gln Ser Ala Glu Phe Ala Arg Ser His Ala115 120 125 130CAA AGC GAA TGG TTG TTT AAG GAA TTG TTT GTG CTG GTG TGC GCT TTG 488Gln Ser Glu Trp Leu Phe Lys Glu Leu Phe Val Leu Val Cys Ala Leu
135 140 145TTT TTT TGG CGT TTG CTT GGA AAA AAT GTG CTT TAGTCCCTTT GATTTAATCA 541Phe Phe Trp Arg Leu Leu Gly Lys Asn Val Leu
150 155AATGAGAGAG TTTTTGGCTA CTATCTAGGA AAT 574
(2) Sequence 672 data:
(i) sequence characteristics:
(A) length: 157 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 672: met Lys Lys Phe Gly Leu Gly Val Tyr Leu Leu Leu Leu Gly Ile Leu 151015 Gly Gly Ser Leu Ile Ile Leu Gly Ala Ile Val Ala Pro Ile Val Phe
20 25 30Lys Ala Ser Ser Val Leu Pro Glu Leu His Leu Thr Pro Phe Glu Ser
35 40 45Gly Lys Leu Met Ala Gln Ile Phe Val Arg Phe Asn Tyr Val Leu Gly
50 55 60Ala Ile Gly Phe Val Val Leu Leu Tyr Glu Ile Ile Ser Phe Ile Tyr65 70 75 80Tyr Lys Arg Ser Leu Val Tyr Leu Ile Leu Gly Val Ala Ile Gly Ala
85 90 95Leu Cys Leu Leu Phe Val Phe Tyr Tyr Thr Pro Tyr Ile Leu Asn Ala
100 105 110Gln Lys Ala Gly Glu Ala Ala Leu Gln Ser Ala Glu Phe Ala Arg Ser
115 120 125His Ala Gln Ser Glu Trp Leu Phe Lys Glu Leu Phe Val Leu Val Cys
130 135 140Ala Leu Phe Phe Trp Arg Leu Leu Gly Lys Asn Val Leu145 150 155
(2) Sequence 673 data:
(i) sequence characteristics:
(A) length: 1780bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1727
(D) Other information:
(xi) Description of the sequence: sequence 673: ATAACCCGGT GTTTTTGATA GACAAATACG AAGCCGTTGC TAAAAATTAA ATG ATT 56
Met Ile
1TTT GGG GAT TTT AAA TAT CAA AAA AGC GTT AAA AAA CTC ACA GCC ACC 104Phe Gly Asp Phe Lys Tyr Gln Lys Ser Val Lys Lys Leu Thr Ala Thr
5 10 15AAT CTT AAT GAG CTT AAA AAC GCC CTG GAT TTC ATC TCT CAA AAT AGG 152Asn Leu Asn Glu Leu Lys Asn Ala Leu Asp Phe Ile Ser Gln Asn Arg
20 25 30GGG AAT GGG TAT TTT GTG GGG TAT CTT TTA TAT GAA GCG CGC TTA GCG 200Gly Asn Gly Tyr Phe Val Gly Tyr Leu Leu Tyr Glu Ala Arg Leu Ala35 40 45 50TTT TTA GAT GAA AAT TTT CAA AGC CAA ACC CCT TTT TTG TAT TTT GAA 248Phe Leu Asp Glu Asn Phe Gln Ser Gln Thr Pro Phe Leu Tyr Phe Glu
55 60 65CAA TTT TTA GAA AGA AAA AAA TAT TCT TTA GAG CCT TTA AAA GAG CAT 296Gln Phe Leu Glu Arg Lys Lys Tyr Ser Leu Glu Pro Leu Lys Glu His
70 75 80GCG TTT TAC CCT AAA ATC CAT AGT TCT TTA GAT CAA AAA ACT TAT TTC 344Ala Phe Tyr Pro Lys Ile His Ser Ser Leu Asp Gln Lys Thr Tyr Phe
85 90 95AAG CAG TTT AAA GCC GTT AAA GAG CGT CTC AAA AAC GGC GAC ACC TAT 392Lys Gln Phe Lys Ala Val Lys Glu Arg Leu Lys Asn Gly Asp Thr Tyr
100 105 110CAA GTG AAT CTCACA ATG GAT TTA TTT TTA GAC ACT AAA GCC AAA CCA 440Gln Val Asn Leu Thr Met Asp Leu Phe Leu Asp Thr Lys Ala Lys Pro115 120 125 130AAG CGC GTT TTT AAG GAG GTG GTA CAC AAC CAA AAC ACG CCT TTT AAG 488Lys Arg Val Phe Lys Glu Val Val His Asn Gln Asn Thr Pro Phe Lys
135 140 145GCT TTT ATA GAA AAT GAG TTT GGG AGC GTT TTA AGC TTT TCG CCG GAA 536Ala Phe Ile Glu Asn Glu Phe Gly Ser Val Leu Ser Phe Ser Pro Glu
150 155 160TTG TTT TTT GAA TTA GAG TTT TTA GAT ACA GCG ATT AAG ATT ATT ACA 584Leu Phe Phe Glu Leu Glu Phe Leu Asp Thr Ala Ile Lys Ile Ile Thr
165 170 175AAA CCC ATG AAA GGC ACG ATC GCT CGC TCA AAA AAC CCC TTA ATA GAT 632Lys Pro Met Lys Gly Thr Ile Ala Arg Ser Lys Asn Pro Leu Ile Asp
180 185 190GAA AAA AAC CGA TTG TTT TTG CAA AAT GAT GAC AAA AAC AGA AGC GAA 680Glu Lys Asn Arg Leu Phe Leu Gln Asn Asp Asp Lys Asn Arg Ser Glu195 200 205 210AAT GTG ATG ATT GTG GAT TTA TTG CGT AAC GAT TTG AGC CGC TTG GCC 728Asn Val Met Ile Val Asp Leu Leu Arg Asn Asp Leu Ser Arg Leu Ala
215 220 225TTA AAA AAT AGC GTG AAA GTC AAT CAA TTG TTT GAA ATC ATC AGC TTG 776Leu Lys Asn Ser Val Lys Val Asn Gln Leu Phe Glu Ile Ile Ser Leu
230 235 240CCT AGC GTG TAT CAA ATG ATA AGC GAG ATT GAA GCG AAA TTG CCC CTA 824Pro Ser Val Tyr Gln Met Ile Ser Glu Ile Glu Ala Lys Leu Pro Leu
245 250 255AAA ACC AGC TTG TTT GAG ATT TTT AAG GCG TTG TTC CCT TGC GGC TCT 872Lys Thr Ser Leu PheGlu Ile Phe Lys Ala Leu Phe Pro Cys Gly Ser
260 265 270GTG ACC GGA TGC CCT AAA ATC AAA ACC ATG CAA ATC ATT GAA AGT TTA 920Val Thr Gly Cys Pro Lys Ile Lys Thr Met Gln Ile Ile Glu Ser Leu275 280 285 290GAA AAA CGC CCT AGG GGG GTG TAT TGC GGG GCG ATA GGC ATG GTT GAA 968Glu Lys Arg Pro Arg Gly Val Tyr Cys Gly Ala Ile Gly Met Val Glu
295 300 305GAA AAA AAA GCC CTT TTT AGC GTG CCT ATC CGC ACT TTA GAA AAA AGA 1016Glu Lys Lys Ala Leu Phe Ser Val Pro Ile Arg Thr Leu Glu Lys Arg
310 315 320GTG CAC GAA AAT TTT TTG CAT TTA GGG GTA GGG AGT GGG GTA ACT TAT 1064Val His Glu Asn Phe Leu His Leu Gly Val Gly Ser Gly Val Thr Tyr
325 330 335AAA AGT AAA GCG CCA AAA GAA TAT GAA GAA AGC TTT TTG AAA TCC TTT 1112Lys Ser Lys Ala Pro Lys Glu Tyr Glu Glu Ser Phe Leu Lys Ser Phe
340 345 350TTT GTG ATG CCC AAA ATA GAA TTT GAG ATT GTA GAA ACG ATG AAA ATT 1160Phe Val Met Pro Lys Ile Glu Phe Glu Ile Val Glu Thr Met Lys Ile355 360 365 370ATC AAA AAG GAT CAA AAA TTA GAG ATT AAT AAT AAA AAC GCC CAT AAA 1208Ile Lys Lys Asp Gln Lys Leu Glu Ile Asn Asn Lys Asn Ala His Lys
375 380 385GAA CGC TTA ATG AAT AGC ACT CGA TAT TTT AAC TTT AAA TAC GAT GAA 1256Glu Arg Leu Met Asn Ser Thr Arg Tyr Phe Asn Phe Lys Tyr Asp Glu
390 395 400AAT CTT TTA GAT TTT GAA TTA GAA AAA GAA GGG GTT TTA AGG GTT TTA 1304Asn Leu Leu Asp Phe Glu Leu Glu Lys Glu Gly Val Leu Arg Val Leu
405410 415CTC AAT AAA AAG GGC AAG CTC ATT AAA GAA TAC AAA ACC TTA GAG CCT 1352Leu Asn Lys Lys Gly Lys Leu Ile Lys Glu Tyr Lys Thr Leu Glu Pro
420 425 430TTA AAA AGC CTA GAA ATC CGT TTG AGT GAA GCC CCC ATT GAT AAA CGC 1400Leu Lys Ser Leu Glu Ile Arg Leu Ser Glu Ala Pro Ile Asp Lys Arg435 440 445 450AAT GAT TTT TTA TAC CAT AAG ACC ACT TAT GCC CCT TTT TAT CAA AAG 1448Asn Asp Phe Leu Tyr His Lys Thr Thr Tyr Ala Pro Phe Tyr Gln Lys
455 460 465GCT CGA GCG CTC ATT AAA AAG GGC GTT ATG TTT GAT GAA ATC TTT TAT 1496Ala Arg Ala Leu Ile Lys Lys Gly Val Met Phe Asp Glu Ile Phe Tyr
470 475 480AAC CAG GAT TTG GAA CTC ACT GAG GGC GCT AGG AGC AAT CTT GTT TTA 1544Asn Gln Asp Leu Glu Leu Thr Glu Gly Ala Arg Ser Asn Leu Val Leu
485 490 495GAA ATC CAT AAC AGG CTT TTA ACC CCT TAT TTT AGC GCG GGC GCG TTA 1592Glu Ile His Asn Arg Leu Leu Thr Pro Tyr Phe Ser Ala Gly Ala Leu
500 505 510AAC GGG ACG GGT GTT GTG GGG TTG TTA AAA AAG GGT CTT GTT GGG CAT 1640Asn Gly Thr Gly Val Val Gly Leu Leu Lys Lys Gly Leu Val Gly His515 520 525 530GCA CCT TTG AAA TTG CAA GAT TTG CAA AAA GCG TCT AAA ATC TAT TGT 1688Ala Pro Leu Lys Leu Gln Asp Leu Gln Lys Ala Ser Lys Ile Tyr Cys
535 540 545ATT AAC GCG CTA TAT GGC TTA GTG GAA GTG AAA ATA AAA TAACTATAAA AA 1739Ile Asn Ala Leu Tyr Gly Leu Val Glu Val Lys Ile Lys
550 555CAGAGCGGCT AAAACCTCAT TTTTAGAAAT AGGTTACCCA A 1780
(2) Sequence 674 data:
(i) sequence characteristics:
(A) length: 559 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 674: met Ile Phe Gly Asp Phe Lys Tyr Gln Lys Ser Val Lys Lys Leu Thr 151015 Ala Thr Asn Leu Asn Glu Leu Lys Asn Ala Leu Asp Phe Ile Ser Gln
20 25 30Asn Arg Gly Asn Gly Tyr Phe Val Gly Tyr Leu Leu Tyr Glu Ala Arg
35 40 45Leu Ala Phe Leu Asp Glu Asn Phe Gln Ser Gln Thr Pro Phe Leu Tyr
50 55 60Phe Glu Gln Phe Leu Glu Arg Lys Lys Tyr Ser Leu Glu Pro Leu Lys65 70 75 80Glu His Ala Phe Tyr Pro Lys Ile His Ser Ser Leu Asp Gln Lys Thr
85 90 95Tyr Phe Lys Gln Phe Lys Ala Val Lys Glu Arg Leu Lys Asn Gly Asp
100 105 110Thr Tyr Gln Val Asn Leu Thr Met Asp Leu Phe Leu Asp Thr Lys Ala
115 120 125Lys Pro Lys Arg Val Phe Lys Glu Val Val His Asn Gln Asn Thr Pro
130 135 140Phe Lys Ala Phe Ile Glu Asn Glu Phe Gly Ser Val Leu Ser Phe Ser145 150 155 160Pro Glu Leu Phe Phe Glu Leu Glu Phe Leu Asp Thr Ala Ile Lys Ile
165 170 175Ile Thr Lys Pro Met Lys Gly Thr Ile Ala Arg Ser Lys Asn Pro Leu
180 185 190Ile Asp Glu Lys Asn Arg Leu Phe Leu Gln Asn Asp Asp Lys Asn Arg
195 200 205Ser Glu Asn Val Met Ile Val Asp Leu Leu Arg Asn Asp Leu Ser Arg
210 215 220Leu Ala Leu Lys Asn Ser Val Lys ValAsn Gln Leu Phe Glu Ile Ile225 230 235 240Ser Leu Pro Ser Val Tyr Gln Met Ile Ser Glu Ile Glu Ala Lys Leu
245 250 255Pro Leu Lys Thr Ser Leu Phe Glu Ile Phe Lys Ala Leu Phe Pro Cys
260 265 270Gly Ser Val Thr Gly Cys Pro Lys Ile Lys Thr Met Gln Ile Ile Glu
275 280 285Ser Leu Glu Lys Arg Pro Arg Gly Val Tyr Cys Gly Ala Ile Gly Met
290 295 300Val Glu Glu Lys Lys Ala Leu Phe Ser Val Pro Ile Arg Thr Leu Glu305 310 315 320Lys Arg Val His Glu Asn Phe Leu His Leu Gly Val Gly Ser Gly Val
325 330 335Thr Tyr Lys Ser Lys Ala Pro Lys Glu Tyr Glu Glu Ser Phe Leu Lys
340 345 350Ser Phe Phe Val Met Pro Lys Ile Glu Phe Glu Ile Val Glu Thr Met
355 360 365Lys Ile Ile Lys Lys Asp Gln Lys Leu Glu Ile Asn Asn Lys Asn Ala
370 375 380His Lys Glu Arg Leu Met Asn Ser Thr Arg Tyr Phe Asn Phe Lys Tyr385 390 395 400Asp Glu Asn Leu Leu Asp Phe Glu Leu Glu Lys Glu Gly Val Leu Arg
405 410 415Val Leu Leu Asn Lys Lys Gly Lys Leu Ile Lys Glu Tyr Lys Thr Leu
420 425 430Glu Pro Leu Lys Ser Leu Glu Ile Arg Leu Ser Glu Ala Pro Ile Asp
435 440 445Lys Arg Asn Asp Phe Leu Tyr His Lys Thr Thr Tyr Ala Pro Phe Tyr
450 455 460Gln Lys Ala Arg Ala Leu Ile Lys Lys Gly Val Met Phe Asp Glu Ile465 470 475 480Phe Tyr Asn Gln Asp Leu Glu Leu Thr Glu Gly Ala Arg Ser Asn Leu
485 490 495Val Leu Glu Ile His Asn Arg Leu Leu Thr Pro Tyr Phe Ser Ala Gly
500 505 510Ala Leu Asn Gly Thr Gly Val Val Gly Leu Leu Lys Lys Gly Leu Val
515 520 525Gly His Ala Pro Leu Lys Leu Gln Asp Leu Gln Lys Ala Ser Lys Ile
530 535 540Tyr Cys Ile Asn Ala Leu Tyr Gly Leu Val Glu Val Lys Ile Lys545 550 555
(2) Sequence 675 data:
(i) sequence characteristics:
(A) length: 958 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...905
(D) Other information:
(xi) Description of the sequence: sequence 675: TTAGTGGATA TTTTATACGC TTTTATTGAT CCTAGAATAA GGTTGTCATA ATG GAG 56
Met Glu
1TCT TTT AGA GAG TTT ATC CAA CAA TTC AAA AAA AAT AAG GCA GCG GTC 104Ser Phe Arg Glu Phe Ile Gln Gln Phe Lys Lys Asn Lys Ala Ala Val
5 10 15GTT GGG GCT TGG ATT GTG CTT TTA TTG GTA ATT TGC GCG ATT TTT GCG 152Val Gly Ala Trp Ile Val Leu Leu Leu Val Ile Cys Ala Ile Phe Ala
20 25 30CCC CTT TTA GCC CCG CAT GAT CCT TAT GTC CAA AAC GCG CAA GAT CGC 200Pro Leu Leu Ala Pro His Asp Pro Tyr Val Gln Asn Ala Gln Asp Arg35 40 45 50CTT TTG AAG CCT ATA TGG GAG CAT GGA GGG AAT GCT AAA TAC CTT TTA 248Leu Leu Lys Pro Ile Trp Glu His Gly Gly Asn Ala Lys Tyr Leu Leu
55 60 65GGC ACC GAT GAT TTG GGG CGC GAT ATT TTG AGC CGC TTG ATC TAT GGG 296Gly Thr Asp Asp Leu Gly Arg Asp Ile Leu Ser Arg Leu Ile Tyr Gly
70 75 80GCC AGG ATT TCT TTA ACC ATA GGG ATT GTT TCT ATG GGG ATT GCG GTG 344Ala Arg Ile Ser Leu Thr Ile Gly Ile Val Ser Met Gly Ile Ala Val
85 90 95TTT TTT GGC ACG ATA CTA GGG CTA ATA GCG GGG TAT TTT GGG GGG AAA 392Phe Phe Gly Thr Ile Leu Gly Leu Ile Ala Gly Tyr Phe Gly Gly Lys
100105 110ACA GAT GCA ATT ATC ATG CGT ATC ATG GAC ATC ATG TTC GCT TTG CCC 440Thr Asp Ala Ile Ile Met Arg Ile Met Asp Ile Met Phe Ala Leu Pro115 120 125 130TCT ATT TTA TTG ATC GTG ATT GTG GTC GCG GTG TTA GGG CCT TCA CTC 488Ser Ile Leu Leu Ile Val Ile Val Val Ala Val Leu Gly Pro Ser Leu
135 140 145ACT AAC GCC ATG CTC GCT ATT GGG TTT GTG GGG ATT CCT GGG TTT GCA 536Thr Asn Ala Met Leu Ala Ile Gly Phe Val Gly Ile Pro Gly Phe Ala
150 155 160AGA TTG GTG CGC AGT TCC GTG CTA GGT GAA AAA GAA AAA GAA TAC GTG 584Arg Leu Val Arg Ser Ser Val Leu Gly Glu Lys Glu Lys Glu Tyr Val
165 170 175ATC GCT TCT AAA ATC AAT GGC TCT TCG CAT CTT CGT TTG ATG TGT AAG 632Ile Ala Ser Lys Ile Asn Gly Ser Ser His Leu Arg Leu Met Cys Lys
180 185 190GTG ATT TTC CCT AAT TGC ATT ATC CCT TTA ATC GTT CAA ACG ACA ATG 680Val Ile Phe Pro Asn Cys Ile Ile Pro Leu Ile Val Gln Thr Thr Met195 200 205 210GGT TTT GCT TCC ACG GTT TTA GAA GCG GCT GCA CTG AGC TTC TTA GGT 728Gly Phe Ala Ser Thr Val Leu Glu Ala Ala Ala Leu Ser Phe Leu Gly
215 220 225CTT GGG GCC CAA CCT CCC AAA CCC GAA TGG GGA GCG ATG TTG ATG AAT 776Leu Gly Ala Gln Pro Pro Lys Pro Glu Trp Gly Ala Met Leu Met Asn
230 235 240TCC ATG CAA TAC ATC GCT ACC GCT CCT TGG ATG CTT GTT TTC CCT GGG 824Ser Met Gln Tyr Ile Ala Thr Ala Pro Trp Met Leu Val Phe Pro Gly
245 250 255GTG ATG ATT TTT TTA ACG GTC ATG AGT TTT AAT CTG GTA GGC GAT GGC 872Val Met Ile Phe Leu Thr Val Met Ser Phe Asn Leu Val Gly Asp Gly
260 265 270ATC ATG GAC GCT TTA GAT CCT AAA CGC ACC TCT TAAAAGGAGC TTGCATGATT 925Ile Met Asp Ala Leu Asp Pro Lys Arg Thr Ser275 280 285TTAGAAGTTA AAGATTTAAA AACTTATTTT TTC 958
(2) Sequence 676 data:
(i) sequence characteristics:
(A) length: 285 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 676: met Glu Ser Phe Arg Glu Phe Ile Gln Gln Phe Lys Lys Asn Lys Ala 151015 Ala Val Val Gly Ala Trp Ile Val Leu Leu Leu Val Ile Cys Ala Ile
20 25 30Phe Ala Pro Leu Leu Ala Pro His Asp Pro Tyr Val Gln Asn Ala Gln
35 40 45Asp Arg Leu Leu Lys Pro Ile Trp Glu His Gly Gly Asn Ala Lys Tyr
50 55 60Leu Leu Gly Thr Asp Asp Leu Gly Arg Asp Ile Leu Ser Arg Leu Ile65 70 75 80Tyr Gly Ala Arg Ile Ser Leu Thr Ile Gly Ile Val Ser Met Gly Ile
85 90 95Ala Val Phe Phe Gly Thr Ile Leu Gly Leu Ile Ala Gly Tyr Phe Gly
100 105 110Gly Lys Thr Asp Ala Ile Ile Met Arg Ile Met Asp Ile Met Phe Ala
115 120 125Leu Pro Ser Ile Leu Leu Ile Val Ile Val Val Ala Val Leu Gly Pro
130 135 140Ser Leu Thr Asn Ala Met Leu Ala Ile Gly Phe Val Gly Ile Pro Gly145 150 155 160Phe Ala Arg Leu Val Arg Ser Ser Val Leu Gly Glu Lys Glu Lys Glu
165 170 175Tyr Val Ile Ala Ser Lys Ile Asn Gly Ser Ser His Leu Arg Leu Met
180 185 190Cys Lys Val Ile Phe Pro Asn Cys Ile Ile Pro Leu Ile Val Gln Thr
195 200 205Thr Met Gly Phe Ala Ser Thr Val Leu Glu Ala Ala Ala Leu Ser Phe
210 215 220Leu Gly Leu Gly Ala Gln Pro Pro Lys Pro Glu Trp Gly Ala Met Leu225 230 235 240Met Asn Ser Met Gln Tyr Ile Ala Thr Ala Pro Trp Met Leu Val Phe
245 250 255Pro Gly Val Met Ile Phe Leu Thr Val Met Ser Phe Asn Leu Val Gly
260 265 270Asp Gly Ile Met Asp Ala Leu Asp Pro Lys Arg Thr Ser
275 280 285
(2) Data of sequence 677:
(i) sequence characteristics:
(A) length: 791 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 95...727
(D) Other information:
(xi) Description of the sequence: sequence 677: CCTTGTTAAA AATGTTAGTT GGTGCAAGCT TGCTGACACA CGCCTTAATA GCTAAAGAAG 60AAAGCGCAGC NCTTCTTGGA CAAAAAATTT GTAT ATG GGA GTC AAT TAC CAA ACA 115
Met Gly Val Asn Tyr Gln Thr
1 5GGT TCT ATC AAT TTA ATG ACT AAT ATC CAT GAA GTT AGA GAA GTT ACT 163Gly Ser Ile Asn Leu Met Thr Asn Ile His Glu Val Arg Glu Val Thr
10 15 20AAC TAT CAA ACC GGT TAC ACC AAT ATT ATA ACT AGC GTT AAT AGC GTT 211Asn Tyr Gln Thr Gly Tyr Thr Asn Ile Ile Thr Ser Val Asn Ser Val
25 30 35AAA AAG CTC ACC AAC ATG GGA TCT AAT GGG ATT GGA TTA GTC ATG GGT 259Lys Lys Leu Thr Asn Met Gly Ser Asn Gly Ile Gly Leu Val Met Gly40 45 50 55TAT AAC CAC TTT TTC CAT CCG GAT AAA ATC TTG GGC TTG CGC TAT TTC 307Tyr Asn His Phe Phe His Pro Asp Lys Ile Leu Gly Leu Arg Tyr Phe
60 65 70GCT TTT TTA GAT TGG CAA GGC TAT GGC ATG AGA TAC CCT AAA GGC TAT 355Ala Phe Leu Asp Trp Gln Gly Tyr Gly Met Arg Tyr Pro Lys Gly Tyr
75 80 85TAT GGC GGC AAT AAC ATG ATC ACT TAT GGC GTG GGC GTG GAT GCA GTG 403Tyr Gly Gly Asn Asn Met Ile Thr Tyr Gly Val Gly Val Asp Ala Val
90 95 100TGG AAT TTC TTT CAA GGG AGT TTC TAT CAA GAT GAC ATT AGC GTG GAT 451Trp AsnPhe Phe Gln Gly Ser Phe Tyr Gln Asp Asp Ile Ser Val Asp
105 110 115ATT GGC GTT TTT GGG GGG ATT GCG ATT GCG GGG AAT AGC TGG TAT ATT 499Ile Gly Val Phe Gly Gly Ile Ala Ile Ala Gly Asn Ser Trp Tyr Ile120 125 130 135GGC AGT AAA GGG CAG GAA TTG TTA GGT ATC ACT AAC AGC AGC GCG GTT 547Gly Ser Lys Gly Gln Glu Leu Leu Gly Ile Thr Asn Ser Ser Ala Val
140 145 150GAT AAC ACC TCT TTT CAA TTC CTC TTT AAC TTT GGC CTC AAG GCT TTA 595Asp Asn Thr Ser Phe Gln Phe Leu Phe Asn Phe Gly Leu Lys Ala Leu
155 160 165TTT GTA GAT GAG CAT GAA TTT GAA ATC GGT TTT AAA TTC CCC ACC ATT 643Phe Val Asp Glu His Glu Phe Glu Ile Gly Phe Lys Phe Pro Thr Ile
170 175 180AAT AAC AAA TAC TAC ACC ACT GAC GCG CTC AAG GTT CAA ATG CGT AGG 691Asn Asn Lys Tyr Tyr Thr Thr Asp Ala Leu Lys Val Gln Met Arg Arg
185 190 195GTC TTT GCC TTT TAT GTG GGG TAT AAT TAC CAC TTC TAAAGGGCTT TTAAAA 743Val Phe Ala Phe Tyr Val Gly Tyr Asn Tyr His Phe200 205 210CCCAACGCAA CTCCCTAACA TCTTTTGGTA ATAGCTCTTG GCTTTGAG 791
(2) Sequence 678 data:
(i) sequence characteristics:
(A) length: 211 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi)Description of the sequence: sequence 678: met Gly Val Asn Tyr Gln Thr Gly Ser Ile Asn Leu Met Thr Asn Ile 151015 His Glu Val Arg Glu Val Thr Asn Tyr Gln Thr Gly Tyr Thr Asn Ile
20 25 30Ile Thr Ser Val Asn Ser Val Lys Lys Leu Thr Asn Met Gly Ser Asn
35 40 45Gly Ile Gly Leu Val Met Gly Tyr Asn His Phe Phe His Pro Asp Lys
50 55 60Ile Leu Gly Leu Arg Tyr Phe Ala Phe Leu Asp Trp Gln Gly Tyr Gly65 70 75 80Met Arg Tyr Pro Lys Gly Tyr Tyr Gly Gly Asn Asn Met Ile Thr Tyr
85 90 95Gly Val Gly Val Asp Ala Val Trp Asn Phe Phe Gln Gly Ser Phe Tyr
100 105 110Gln Asp Asp Ile Ser Val Asp Ile Gly Val Phe Gly Gly Ile Ala Ile
115 120 125Ala Gly Asn Ser Trp Tyr Ile Gly Ser Lys Gly Gln Glu Leu Leu Gly
130 135 140Ile Thr Asn Ser Ser Ala Val Asp Asn Thr Ser Phe Gln Phe Leu Phe145 150 155 160Asn Phe Gly Leu Lys Ala Leu Phe Val Asp Glu His Glu Phe Glu Ile
165 170 175Gly Phe Lys Phe Pro Thr Ile Asn Asn Lys Tyr Tyr Thr Thr Asp Ala
180 185 190Leu Lys Val Gln Met Arg Arg Val Phe Ala Phe Tyr Val Gly Tyr Asn
195 200 205Tyr His Phe
210
(2) Sequence 679 data:
(i) sequence characteristics:
(A) length: 517 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...464
(D) Other information:
(xi) Description of the sequence: sequence 679: AGATTTCATT CGAGGTAGAA AATACATTGA AAAAGCGTGT GAATTAAACG ATG GTA 56
Met Val
1GGG GGT GGA ACG GTA AAA AAA GAC TTG AAG AAA GCC ATT CAA TAC TAT 104Gly Gly Gly Thr Val Lys Lys Asp Leu Lys Lys Ala Ile Gln Tyr Tyr
5 10 15GTT AAA GCG TGT GAA TTG AAT GAA ATG TTT GGG TGT CTG TCA TTA GTT 152Val Lys Ala Cys Glu Leu Asn Glu Met Phe Gly Cys Leu Ser Leu Val
20 25 30TCG AAC TCT CAA ATA AAC AAA CAA AAA CTC TTT CAA TAT CTC TCT AAA 200Ser Asn Ser Gln Ile Asn Lys Gln Lys Leu Phe Gln Tyr Leu Ser Lys35 40 45 50GCT TGT GAA TTA AAT AGT GGT AAT GGA TGT AGG TTT TTA GGG GAT TTT 248Ala Cys Glu Leu Asn Ser Gly Asn Gly Cys Arg Phe Leu Gly Asp Phe
55 60 65TAT GAG AAT GGA AAA TAT GTA AAA AAG GAT TTA AGA AAA GCT GCT CAA 296Tyr Glu Asn Gly Lys Tyr Val Lys Lys Asp Leu Arg Lys Ala Ala Gln
70 75 80TAC TAC TCT AAA GCT TGTGGA TTA AAT GAT CAA GAT GGG TGT TTA ATA 344Tyr Tyr Ser Lys Ala Cys Gly Leu Asn Asp Gln Asp Gly Cys Leu Ile
85 90 95CTA GGA TAT AAG CAA TAT GCT GGC AAG GGC GTA GTC AAA AAT GAA AAA 392Leu Gly Tyr Lys Gln Tyr Ala Gly Lys Gly Val Val Lys Asn Glu Lys
100 105 110CAA GCG GTG AAA ACC TTT GAA AAG GCT TGT AGG TTA GGA TCT GAA GAC 440Gln Ala Val Lys Thr Phe Glu Lys Ala Cys Arg Leu Gly Ser Glu Asp115 120 125 130GCA TGT GGT ATT TTA AAC AAC TAC TAGATTTGAA ATAAATGCTG TTTTTTAGCT 494Ala Cys Gly Ile Leu Asn Asn Tyr
135GGCTTTCATG TTTTTGTAAC CCC 517
(2) Sequence 680 data:
(i) sequence characteristics:
(A) length: 138 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 680: met Val Gly Gly Gly Thr Val Lys Lys Asp Leu Lys Lys Ala Ile Gln 151015 Tyr Tyr Val Lys Ala Cys Glu Leu Asn Glu Met Phe Gly Cys Leu Ser
20 25 30Leu Val Ser Asn Ser Gln Ile Asn Lys Gln Lys Leu Phe Gln Tyr Leu
35 40 45Ser Lys Ala Cys Glu Leu Asn Ser Gly Asn Gly Cys Arg Phe Leu Gly
50 55 60Asp Phe Tyr Glu Asn Gly Lys Tyr Val Lys Lys Asp Leu Arg Lys Ala6570 75 80Ala Gln Tyr Tyr Ser Lys Ala Cys Gly Leu Asn Asp Gln Asp Gly Cys
85 90 95Leu Ile Leu Gly Tyr Lys Gln Tyr Ala Gly Lys Gly Val Val Lys Asn
100 105 110Glu Lys Gln Ala Val Lys Thr Phe Glu Lys Ala Cys Arg Leu Gly Ser
115 120 125Glu Asp Ala Cys Gly Ile Leu Asn Asn Tyr
130 135
(2) Sequence 681 data:
(i) sequence characteristics:
(A) length: 451bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...398
(D) Other information:
(xi) Description of the sequence: sequence 681: GTGGAACGCT CTGTCTTAGC AAATTGATCT TAGCGGCGTC GTTTTTGATA GTG GAT 56
Val Asp
1TCA GAG GGG TTT TCG CCT TCT ATT TAT ACC GAC AAG ACA GGG CAT CCC 104Ser Glu Gly Phe Ser Pro Ser Ile Tyr Thr Asp Lys Thr Gly His Pro
5 10 15ACG ATT GGC TAT GGC TAT AAT TTG AGC GTT TAT TCT TAT GAG GGT AAG 152Thr Ile Gly Tyr Gly Tyr Asn Leu Ser Val Tyr Ser Tyr Glu Gly Lys
20 25 30CGT ATC ACC AAA ACA TAT GGG CTT TTA ACT GAC ATA CTC TCT TAT GGG 200Arg Ile Thr Lys Thr Tyr Gly Leu Leu Thr Asp Ile Leu Ser Tyr Gly35 40 45 50TGG TAT AAA AAT TTG GAC GCA ATG AGG AGA ATG GTC ATC TTG GAT TTG 248Trp Tyr Lys Asn Leu Asp Ala Met Arg Arg Met Val Ile Leu Asp Leu
55 60 65AGC TAC AAT TTA GGC TTG AAC GGA CTG CTC AAA TTC AAG CAA TTC ATC 296Ser Tyr Asn Leu Gly Leu Asn Gly Leu Leu Lys Phe Lys Gln Phe Ile
70 75 80AAG GCC ATA GAG GAT AAA AAT TAT GCT TTG GCT GTG GAG AGA CTG CAA 344Lys Ala Ile Glu Asp Lys Asn Tyr Ala Leu Ala Val Glu Arg Leu Gln
85 90 95AAA AGC CCG TAT TTC AAT CAA GTG AAA AAA GAG CGT CAA GGA ATA TGG 392Lys Ser Pro Tyr Phe Asn Gln Val Lys Lys Glu Arg Gln Gly Ile Trp
100 105 110AAA TTT TGAAATTGGA GGGTTGCGAA AAACATTGTA AGAAAAAATA CGCAATAGAA AA 450Lys Phe115G 451
(2) Sequence 682 data:
(i) sequence characteristics:
(A) length: 116 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 682: val Asp Ser Glu Gly Phe Ser Pro Ser Ile Tyr Thr Asp Lys Thr Gly 151015 His Pro Thr Ile Gly Tyr Gly Tyr Asn Leu Ser Val Tyr Ser Tyr Glu
20 25 30Gly Lys Arg Ile Thr Lys Thr Tyr Gly Leu Leu Thr Asp Ile Leu Ser
35 40 45Tyr Gly Trp Tyr Lys Asn Leu Asp Ala Met Arg Arg Met Val Ile Leu
50 55 60Asp Leu Ser Tyr Asn Leu Gly Leu Asn Gly Leu Leu Lys Phe Lys Gln65 70 75 80Phe Ile Lys Ala Ile Glu Asp Lys Asn Tyr Ala Leu Ala Val Glu Arg
85 90 95Leu Gln Lys Ser Pro Tyr Phe Asn Gln Val Lys Lys Glu Arg Gln Gly
100 105 110Ile Trp Lys Phe
115
(2) Sequence 683 data:
(i) sequence characteristics:
(A) length: 399 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...346
(D) Other information:
(xi) Description of the sequence: sequence 683: ACACAACCAT AGCGACCAAA AACCCGACAG ACCCGCCAAG GAGCGATAA AAC CCA CAA 58
Asn Pro Gln
1AGC TTT TTC AGG AAT ACG CCA CAT TTT TTG ATC AGC CGA ATT TTT ATC 106Ser Phe Phe Arg Asn Thr Pro His Phe Leu Ile Ser Arg Ile Phe Ile
5 10 15CAC CAG CAT GAG AAT AAA AAT CAG AAT ATT GAC TAT GAG CAA CCA AAC 154His Gln His Glu Asn Lys Asn Gln Asn Ile Asp Tyr Glu Gln Pro Asn20 25 30 35GAT AGA AGC AAA TTC CAC GCT CAC CCT TTC AAG AGC GTT TTA ACA ACC 202Asp Arg Ser Lys Phe His Ala His Pro Phe Lys Ser Val Leu Thr Thr
40 45 50CAA ACG CTA CCA CTT GGT TTT TTA GAG AGA GAA AGA GAG AGA AAG CAA 250Gln Thr Leu Pro Leu Gly Phe Leu Glu Arg Glu Arg Glu Arg Lys Gln
55 60 65AAT TTT AAG ATT GAT TCT CAA ATC TAT TCC TTT GCA AAA GTT AAG ATT 298Asn Phe Lys Ile Asp Ser Gln Ile Tyr Ser Phe Ala Lys Val Lys Ile
70 75 80GGG TGT TTT AAC ATG ATT TTT GGC CTG CTC GCA TCA AGC CCT TAT TTT T 347Gly Cys Phe Asn Met Ile Phe Gly Leu Leu Ala Ser Ser Pro Tyr Phe
85 90 95AACATTTCCG CTCCCTTGCT TTTTTAAAGC CTCCCTAAAT TACTACACCA CT 399
(2) Sequence 684 materials:
(i) sequence characteristics:
(A) length: 99 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 684: asn Pro Gln Ser Phe Phe Arg Asn Thr Pro His Phe Leu Ile Ser Arg 151015 Ile Phe Ile His Gln His GluAsn Lys Asn Gln Asn Ile Asp Tyr Glu
20 25 30Gln Pro Asn Asp Arg Ser Lys Phe His Ala His Pro Phe Lys Ser Val
35 40 45Leu Thr Thr Gln Thr Leu Pro Leu Gly Phe Leu Glu Arg Glu Arg Glu
50 55 60Arg Lys Gln Asn Phe Lys Ile Asp Ser Gln Ile Tyr Ser Phe Ala Lys65 70 75 80Val Lys Ile Gly Cys Phe Asn Met Ile Phe Gly Leu Leu Ala Ser Ser
85 90 95Pro Tyr Phe
(2) Sequence 685 data:
(i) sequence characteristics:
(A) length: 522 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...470
(D) Other information:
(xi) Description of the sequence: sequence 685: AAAGACAACC CTAACAAACG CTTCAAAAAC AACAAGAGGG ATAAAAAATA ATG TCT 56
Met Ser
1TAT TTT TTT AAA ATC ATT CTG GGC ACA AGC GTG ATC GTG GGG GTG TTG 104Tyr Phe Phe Lys Ile Ile Leu Gly Thr Ser Val Ile Val Gly Val Leu
5 10 15TTG GGC TTG TGG CGT TTG ACT TAC GAT AAG TTCTAT TTC TCG TTG GTC 152Leu Gly Leu Trp Arg Leu Thr Tyr Asp Lys Phe Tyr Phe Ser Leu Val
20 25 30TTT GTG TTG CTG ATA CTA GGG ATT GTC GCT TGT AGC TAT ATT TCT TTA 200Phe Val Leu Leu Ile Leu Gly Ile Val Ala Cys Ser Tyr Ile Ser Leu35 40 45 50AAA ATG CAT CAG AGG AAA TGC TTC GCC AAG TGT TTC GTG AAT AGT GAA 248Lys Met His Gln Arg Lys Cys Phe Ala Lys Cys Phe Val Asn Ser Glu
55 60 65TCT TTT TTA TCC AAG ATG TTA CAC TCC CCA ATA ATG GTA ATT TGC TTT 296Ser Phe Leu Ser Lys Met Leu His Ser Pro Ile Met Val Ile Cys Phe
70 75 80TAT TTT ATT TTT TCA ATT TTC ACA TCC ATA TCC ATC GTC TAT AGC GTG 344Tyr Phe Ile Phe Ser Ile Phe Thr Ser Ile Ser Ile Val Tyr Ser Val
85 90 95CTG GAC TAT GAT CAG ATG ATG TGG GGG TTT GTT TTT TGC ACT ATC GTT 392Leu Asp Tyr Asp Gln Met Met Trp Gly Phe Val Phe Cys Thr Ile Val
100 105 110GTT TGC GCT GTG GTG TTT GGC ACG CTT GAA AAA AAT GCT CAA GAG TAC 440Val Cys Ala Val Val Phe Gly Thr Leu Glu Lys Asn Ala Gln Glu Tyr115 120 125 130CAT CAA AGA AGA TTA TTT GAT GCT GAT GTC TAGAGAAGTG AGTGCTTTTG TGG 493His Gln Arg Arg Leu Phe Asp Ala Asp Val
135 140GGACTCTTTT CTTCATTGGC TTGAGTTGC 522
(2) Data in sequence 686: (i) sequence characteristics:
(A) length: 140 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 686: met Ser Tyr Phe Phe Lys Ile Ile Leu Gly Thr Ser Val Ile Val Gly 151015 Val Leu Leu Gly Leu Trp Arg Leu Thr Tyr Asp Lys Phe Tyr Phe Ser
20 25 30Leu Val Phe Val Leu Leu Ile Leu Gly Ile Val Ala Cys Ser Tyr Ile
35 40 45Ser Leu Lys Met His Gln Arg Lys Cys Phe Ala Lys Cys Phe Val Asn
50 55 60Ser Glu Ser Phe Leu Ser Lys Met Leu His Ser Pro Ile Met Val Ile65 70 75 80Cys Phe Tyr Phe Ile Phe Ser Ile Phe Thr Ser Ile Ser Ile ValTyr
85 90 95Ser Val Leu Asp Tyr Asp Gln Met Met Trp Gly Phe Val Phe Cys Thr
100 105 110Ile Val Val Cys Ala Val Val Phe Gly Thr Leu Glu Lys Asn Ala Gln
115 120 125Glu Tyr His Gln Arg Arg Leu Phe Asp Ala Asp Val
130 135 140
(2) Sequence 687 data:
(i) sequence characteristics:
(A) length: 976 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...923
(D) Other information:
(xi) Description of the sequence: and (2) a sequence 687: CCCACTGAAG CGTATTCTAA CACCCTTTTA GAATTAGCTA AAAAAGATGA AAA AAT 56
Lys Asn
1CGT AGG CGT AAC CGC GGC GAT GCT AGC GGC ACA GGA TTA GAC AAA CTC 104Arg Arg Arg Asn Arg Gly Asp Ala Ser Gly Thr Gly Leu Asp Lys Leu
5 10 15ATT GAC GCT TAN CCT TTG CGC TTT TTT GAT GTC GCT ATC GCT GAG CAA 152Ile Asp Ala Xaa Pro Leu Arg Phe Phe Asp Val Ala Ile Ala Glu Gln
20 25 30CAC GCT TTA ACT TCT AGC AGC GCT ATG GCT AAA GAG GGG TTT AAA CCT 200His Ala Leu Thr Ser Ser Ser Ala Met Ala Lys Glu Gly Phe Lys Pro35 40 45 50TTT GTG AGC ATC TAT TCT ACT TTT TTG CAG AGG GCT TAT GAT TCT ATT 248Phe Val Ser Ile Tyr Ser Thr Phe Leu Gln Arg Ala Tyr Asp Ser Ile
55 60 65GTG CAT GAC GCT TGT ATT TCT AGC TTG CCG ATT AAA TTA GCC ATT GAC 296Val His Asp Ala Cys Ile Ser Ser Leu Pro Ile Lys Leu Ala Ile Asp
70 75 80AGG GCT GGG ATT GTG GGC GAA GAT GGC GAG ACG CAC CAA GGG CTT TTA 344Arg Ala Gly Ile Val Gly Glu Asp Gly Glu Thr His Gln Gly Leu Leu
85 90 95GAC GTG TCG TAT TTG CGC TCT ATC CCT AAC ATG GTC ATT TTT GCC CCA 392Asp Val Ser Tyr Leu Arg Ser Ile Pro Asn Met Val Ile Phe Ala Pro
100 105 110CGA GAC AAT GAGACT TTA AAA AAC GCC GTG CGT TTT GCC AAT GAA CAC 440Arg Asp Asn Glu Thr Leu Lys Asn Ala Val Arg Phe Ala Asn Glu His115 120 125 130GAT TCA AGC CCT TGC GCG TTC CGA TAC CCT AGG GGG TCG TTT GCG TTA 488Asp Ser Ser Pro Cys Ala Phe Arg Tyr Pro Arg Gly Ser Phe Ala Leu
135 140 145AAA GAG GGG GTT TTT GAG CCT AGC GGT TTT GTT TTA GGC CAA AGC GAA 536Lys Glu Gly Val Phe Glu Pro Ser Gly Phe Val Leu Gly Gln Ser Glu
150 155 160TTG TTG AAA AAA GAG GGC GAA ATT TTA CTC ATA GGC TAT GGT AAT GGC 584Leu Leu Lys Lys Glu Gly Glu Ile Leu Leu Ile Gly Tyr Gly Asn Gly
165 170 175GTG GGG CGG GCG CAT TTA GTC CAA CTG GCT TTA AAA GAA AAA AAC ATA 632Val Gly Arg Ala His Leu Val Gln Leu Ala Leu Lys Glu Lys Asn Ile
180 185 190GAA TGC GCT CTC TTG GAT CTC AGG TTT TTA AAG CCT TTA GAT CCA AAT 680Glu Cys Ala Leu Leu Asp Leu Arg Phe Leu Lys Pro Leu Asp Pro Asn195 200 205 210TTA AGC GCG ATC GTT GCC CCT TAT CAA AAG CTC TAT GTT TTT AGC GAT 728Leu Ser Ala Ile Val Ala Pro Tyr Gln Lys Leu Tyr Val Phe Ser Asp
215 220 225AAT TAC AAG CTT GGA GGG GTG GCT AGC GCG ATT TTA GAG TTT TTG AGC 776Asn Tyr Lys Leu Gly Gly Val Ala Ser Ala Ile Leu Glu Phe Leu Ser
230 235 240GAA CAA AAT ATT TTA AAG CCT GTT AAA AGC TTT GAA ATC ATT GAT GAA 824Glu Gln Asn Ile Leu Lys Pro Val Lys Ser Phe Glu Ile Ile Asp Glu
245 250 255TTT ATC ATG CAT GGG AAC ACC GCT TTA GTG GAA AAA TCC TTA GGA TTA 872Phe Ile Met His GlyAsn Thr Ala Leu Val Glu Lys Ser Leu Gly Leu
260 265 270GAC ACA GAG AGT TTG ACT GAC GCT ATT TTA AAA GAT TTA GGA CAA GAG 920Asp Thr Glu Ser Leu Thr Asp Ala Ile Leu Lys Asp Leu Gly Gln Glu275 280 285 290AGA TGAAAACAAA AGCGCCAATG AAAAATATCC GCAATTTTTC CATTATCGCT CAC 976Arg
(2) Sequence 688 data:
(i) sequence characteristics:
(A) length: 291 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 688: lys Asn Arg Arg Arg Asn Arg Gly Asp Ala Ser Gly Thr Gly Leu Asp 151015 Lys Leu Ile Asp Ala Xaa Pro Leu Arg Phe Phe Asp Val Ala Ile Ala
20 25 30Glu Gln His Ala Leu Thr Ser Ser Ser Ala Met Ala Lys Glu Gly Phe
35 40 45Lys Pro Phe Val Ser Ile Tyr Ser Thr Phe Leu Gln Arg Ala Tyr Asp
50 55 60Ser Ile Val His Asp Ala Cys Ile Ser Ser Leu Pro Ile Lys Leu Ala65 70 75 80Ile Asp Arg Ala Gly Ile Val Gly Glu Asp Gly Glu Thr His Gln Gly
85 90 95Leu Leu Asp Val Ser Tyr Leu Arg Ser Ile Pro Asn Met Val Ile Phe
100 105 110Ala Pro Arg Asp Asn Glu Thr Leu Lys Asn Ala Val Arg Phe Ala Asn
115 120 125Glu His Asp Ser Ser Pro Cys Ala Phe Arg Tyr Pro Arg Gly Ser Phe
130 135 140Ala Leu Lys Glu Gly Val Phe Glu Pro Ser Gly Phe Val Leu Gly Gln145 150 155 160Ser Glu Leu Leu Lys Lys Glu Gly Glu Ile Leu Leu Ile Gly Tyr Gly
165 170 175Asn Gly Val Gly Arg Ala His Leu Val Gln Leu Ala Leu Lys Glu Lys
180 185 190Asn Ile Glu Cys Ala Leu Leu Asp Leu Arg Phe Leu Lys Pro Leu Asp
195 200 205Pro Asn Leu Ser Ala Ile Val Ala Pro Tyr Gln Lys Leu Tyr Val Phe
210 215 220Ser Asp Asn Tyr Lys Leu Gly Gly Val Ala Ser Ala Ile Leu Glu Phe225 230 235 240Leu Ser Glu Gln Asn Ile Leu Lys Pro ValLys Ser Phe Glu Ile Ile
245 250 255Asp Glu Phe Ile Met His Gly Asn Thr Ala Leu Val Glu Lys Ser Leu
260 265 270Gly Leu Asp Thr Glu Ser Leu Thr Asp Ala Ile Leu Lys Asp Leu Gly
275 280 285Gln Glu Arg
290
(2) Sequence 689 data:
(i) sequence characteristics:
(A) length: 1135 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1082
(D) Other information:
(xi) Description of the sequence: and (2) a sequence 689: GGATTAAGAT GTTATAATAG TTGTTATTTT TTCATTTTAA AAGGGGTTTT ATG GCA 56
Met Ala
1TTA TTA TTC ACA GGA GCG TGC GGG TAT ATA GGC TCG CAT ACC GCA AGG 104Leu Leu Phe Thr Gly Ala Cys Gly Tyr Ile Gly Ser His Thr Ala Arg
5 10 15GCG TTT TTA GAA AAA ACC AAA GAA AAT ATC ATT ATT GTA GAT GAC TTA 152Ala Phe Leu Glu Lys Thr Lys Glu Asn Ile Ile Ile Val Asp Asp Leu
20 25 30AGC ACC GGT TTT TTA GAG CAC CTC AAA GCG TTA GAG CAT TAT TAC CCT 200Ser Thr Gly Phe Leu Glu His Leu Lys Ala Leu Glu His Tyr Tyr Pro35 40 45 50AAT AGG GTT GTG TTT ATT CAA GCG AAT TTG AAT GAA ACG CAC AAA TTA 248Asn Arg Val Val Phe Ile Gln Ala Asn Leu Asn Glu Thr His Lys Leu
55 60 65GAC GCC TTT TTG AAT AAG CAG CAG CTA AAA GAT CCC ATT GAA GCC ATC 296Asp Ala Phe Leu Asn Lys Gln Gln Leu Lys Asp Pro Ile Glu Ala Ile
70 75 80TTG CAC TTT GGG GCT AAA ATC TCA GTA GAA GAA TCC ACG CAC TTG CCT 344Leu His Phe Gly Ala Lys Ile Ser Val Glu Glu Ser Thr His Leu Pro
85 90 95TTA GAA TAC TAC ACC AAC AAC ACG CTC AAC ACT TTA GAG CTT GTC AAA 392Leu Glu Tyr Tyr Thr AsnAsn Thr Leu Asn Thr Leu Glu Leu Val Lys
100 105 110CTT TGC TTA AAA CAT GCA ATC AAG CGT TTT ATT TTT TCT TCT ACG GCC 440Leu Cys Leu Lys His Ala Ile Lys Arg Phe Ile Phe Ser Ser Thr Ala115 120 125 130GTG GTT TAT GGC GAA TCT AGT TCA AGT TTG AAT GAA GAA AGC CCC TTA 488Val Val Tyr Gly Glu Ser Ser Ser Ser Leu Asn Glu Glu Ser Pro Leu
135 140 145AAC CCC ATT AAT CCT TAT GGA GCG TCT AAA ATG ATG AGC GAA AGA ATC 536Asn Pro Ile Asn Pro Tyr Gly Ala Ser Lys Met Met Ser Glu Arg Ile
150 155 160TTG TTA GAC ACT TCT AAA ATA GCG GAT TTT AAA TGC GTT ATT TTG CGC 584Leu Leu Asp Thr Ser Lys Ile Ala Asp Phe Lys Cys Val Ile Leu Arg
165 170 175TAT TTC AAT GTG GCT GGG GCA TGC ATG CAC AAT GAT TAT ACC ACC CCT 632Tyr Phe Asn Val Ala Gly Ala Cys Met His Asn Asp Tyr Thr Thr Pro
180 185 190TAC ACG CTA GGG CAA CGC ACG CTC AAC GCC ACG CAT TTG ATC AAA ATC 680Tyr Thr Leu Gly Gln Arg Thr Leu Asn Ala Thr His Leu Ile Lys Ile195 200 205 210GCA TGC GAA TGC GCG GTG GGG AAA AGG AAA AAA ATG GGG ATT TTT GGC 728Ala Cys Glu Cys Ala Val Gly Lys Arg Lys Lys Met Gly Ile Phe Gly
215 220 225ACT AAC TAC CCC ACA AGA GAT GGC ACT TGC ATT AGG GAT TAT ATC CAT 776Thr Asn Tyr Pro Thr Arg Asp Gly Thr Cys Ile Arg Asp Tyr Ile His
230 235 240GTA GAT GAT TTG GCT AAC GCA CAT TTA GCG AGC TAT CAA ACC CTT TTA 824Val Asp Asp Leu Ala Asn Ala His Leu Ala Ser Tyr Gln Thr Leu Leu
245 250 255GAA AAA AAT AAG AGC GAG ATC TAT AAT GTC GGC TAC AAT CAA GGC CAT 872Glu Lys Asn Lys Ser Glu Ile Tyr Asn Val Gly Tyr Asn Gln Gly His
260 265 270AGC GTG AAA GAA GTG ATA GAA AAG GTC AAA GAA ATC TCA AAC AAC GAT 920Ser Val Lys Glu Val Ile Glu Lys Val Lys Glu Ile Ser Asn Asn Asp275 280 285 290TTT TTA GTG GAA ATT TTA GAC AAA CGA CAG GGC GAT CCA GCA AGC CTT 968Phe Leu Val Glu Ile Leu Asp Lys Arg Gln Gly Asp Pro Ala Ser Leu
295 300 305ATT GCC AAT AAC GCT AAA ATC TTA CAA AAC ACC TCT TTC AAA CCC CTT 1016Ile Ala Asn Asn Ala Lys Ile Leu Gln Asn Thr Ser Phe Lys Pro Leu
310 315 320TAT AAC AAC CTA GAC ACC ATT ATC AAA AGC GCT CTA GAT TGG GAA GAA 1064Tyr Asn Asn Leu Asp Thr Ile Ile Lys Ser Ala Leu Asp Trp Glu Glu
325 330 335CAC CTT TTG AGG TTT CAA TAATACACCC TGTGCAAATA CAAGCCATTA GCCATTAT 1120His Leu Leu Arg Phe Gln
340GGGCGTTCTT ATAGT 1135
(2) Sequence 690 data:
(i) sequence characteristics:
(A) length: 344 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 690: met Ala Leu Leu Phe Thr Gly Ala Cys Gly Tyr Ile Gly Ser His Thr 151015 AlaArg Ala Phe Leu Glu Lys Thr Lys Glu Asn Ile Ile Ile Val Asp
20 25 30Asp Leu Ser Thr Gly Phe Leu Glu His Leu Lys Ala Leu Glu His Tyr
35 40 45Tyr Pro Asn Arg Val Val Phe Ile Gln Ala Asn Leu Asn Glu Thr His
50 55 60Lys Leu Asp Ala Phe Leu Asn Lys Gln Gln Leu Lys Asp Pro Ile Glu65 70 75 80Ala Ile Leu His Phe Gly Ala Lys Ile Ser Val Glu Glu Ser Thr His
85 90 95Leu Pro Leu Glu Tyr Tyr Thr Asn Asn Thr Leu Asn Thr Leu Glu Leu
100 105 110Val Lys Leu Cys Leu Lys His Ala Ile Lys Arg Phe Ile Phe Ser Ser
115 120 125Thr Ala Val Val Tyr Gly Glu Ser Ser Ser Ser Leu Asn Glu Glu Ser
130 135 140Pro Leu Asn Pro Ile Asn Pro Tyr Gly Ala Ser Lys Met Met Ser Glu145 150 155 160Arg Ile Leu Leu Asp Thr Ser Lys Ile Ala Asp Phe Lys Cys Val Ile
165 170 175Leu Arg Tyr Phe Asn Val Ala Gly Ala Cys Met His Asn Asp Tyr Thr
180 185 190Thr Pro Tyr Thr Leu Gly Gln Arg Thr Leu Asn Ala Thr His Leu Ile
195 200 205Lys Ile Ala Cys Glu Cys Ala Val Gly Lys Arg Lys Lys Met Gly Ile
210 215 220Phe Gly Thr Asn Tyr Pro Thr Arg Asp Gly Thr Cys Ile Arg Asp Tyr225 230 235 240Ile His Val Asp Asp Leu Ala Asn Ala His Leu Ala Ser Tyr Gln Thr
245 250 255Leu Leu Glu Lys Asn Lys Ser Glu Ile Tyr Asn Val Gly Tyr Asn Gln
260 265 270Gly His Ser Val Lys Glu Val Ile Glu Lys Val Lys Glu Ile Ser Asn
275 280 285Asn Asp Phe Leu Val Glu Ile Leu Asp Lys Arg Gln Gly Asp Pro Ala
290 295 300Ser Leu Ile Ala Asn Asn Ala Lys Ile Leu Gln Asn Thr Ser Phe Lys305 310 315 320Pro Leu Tyr Asn Asn Leu Asp Thr Ile Ile Lys Ser Ala Leu Asp Trp
325 330 335Glu Glu His Leu Leu Arg Phe Gln
340
(2) Data of sequence 691:
(i) sequence characteristics:
(A) length: 1170bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 97...1119
(D) Other information:
(xi) Description of the sequence: sequence 691: GGAGTTTTTT CTGGCTTTTA GGGGGTTTTA AATTCTTTTA AGGTATTCTA ACAAGACTAT 60ATCATTGAGA TAGTTTTAAG GAAATTAAGG AACAAA ATG GAA GTT TCA CGC AAG 114
Met Glu Val Ser Arg Lys
1 5AAA ATT TAC AAC CCC AAT TCT ACA GAA AGT GTG AAT GAA AGA AAG ATT 162Lys Ile Tyr Asn Pro Asn Ser Thr Glu Ser Val Asn Glu Arg Lys Ile
10 15 20TTT GGG GGC AAT CCT ACA AGC ATG TTT GAT TTG AAT AAG ATC AAG TAT 210Phe Gly Gly Asn Pro Thr Ser Met Phe Asp Leu Asn Lys Ile Lys Tyr
25 30 35CAA TGG GCG GAT CAT TTG TGG AAA ACG ATG CTC GCT AAC ACC TGG TTT 258Gln Trp Ala Asp His Leu Trp Lys Thr Met Leu Ala Asn Thr Trp Phe
40 45 50GCT GAA GAA GTG AGC ATG AAT GAT GAC AAA AGG GAT TAT TTG AAA TTA 306Ala Glu Glu Val Ser Met Asn Asp Asp Lys Arg Asp Tyr Leu Lys Leu55 60 65 70AGC GCA GAG GAA AAG ATC GGT TAT GAC AGA GCT TTA GCG CAA CTC ATT 354Ser Ala Glu Glu Lys Ile Gly Tyr Asp Arg Ala Leu Ala Gln Leu Ile
75 80 85TTT ATG GAC AGC TTG CAA GCG AAT AAT TTA ATT GAC AAT ATC AAT CCC 402Phe Met Asp Ser Leu Gln Ala Asn Asn Leu Ile Asp Asn Ile Asn Pro
90 95 100TTC ATC ACC AGC CCC GAA ATC AAT TTG TGT TTG GTG CGT CAA GCT TAT 450Phe Ile Thr Ser Pro Glu Ile Asn Leu Cys Leu Val Arg Gln Ala Tyr
105 110 115GAA GAA GCC CTA CAC AGC CAT GCG TAT GCG GTG ATG GTA GAA AGC ATA 498Glu Glu Ala Leu His Ser His Ala Tyr Ala Val Met Val Glu Ser Ile
120 125 130AGT GCG AAT ACT GAA GAG ATT TAT GAC ATG TGG CGT AAC GAT ATG CAA 546Ser Ala Asn Thr Glu Glu Ile Tyr Asp Met Trp Arg Asn Asp Met Gln135 140 145 150TTA AAA AGC AAG AAC GAC TAT ATC GCG CAA GTG TAT ATG GAA TTA GCC 594Leu Lys Ser Lys Asn Asp Tyr Ile Ala Gln Val Tyr Met Glu Leu Ala
155 160 165AAA AAC CCC ACA GAA GAA AAC ATT CTC AAA GCG CTT TTT GCT AAC CAG 642Lys Asn Pro Thr Glu Glu Asn Ile Leu Lys Ala Leu Phe Ala Asn Gln
170 175 180ATT TTA GAG GGG ATT TAT TTT TAT AGC GGG TTT AGC TAT TTT TAC ACT 690Ile Leu Glu Gly Ile Tyr Phe Tyr Ser Gly Phe Ser Tyr Phe Tyr Thr
185 190 195TTG GCT AGG AGC GGT AAA ATG CTA GGA TCG GCA CAA ATG ATT CGT TTT 738Leu Ala Arg Ser Gly Lys Met Leu Gly Ser Ala Gln Met Ile Arg Phe
200 205 210ATC CAA AGA GAT GAG GTA ACG CAT TTG ATT TTG TTC CAA AAC ATG ATC 786Ile Gln Arg Asp Glu Val Thr His Leu Ile Leu Phe Gln Asn Met Ile215 220 225 230AAC GCT TTA AGG AAT GAA AGA GCG GAT CTC TTC ACG CCG CAA TTG ATT 834Asn Ala Leu Arg Asn Glu Arg Ala Asp Leu Phe Thr Pro Gln Leu Ile
235 240 245AAT GAA GTC ATA GGA ATG TTT AAA AAA GCG GTA GAA ATT GAA GCT TTG 882Asn Glu Val Ile Gly Met Phe Lys Lys Ala Val Glu Ile Glu Ala Leu
250 255 260TGG GGG GAT TAT ATC ACG CAA GGC AAG ATT TTA GGG CTC ACT TCA AGC 930Trp Gly Asp Tyr Ile Thr Gln Gly Lys Ile Leu Gly Leu Thr Ser Ser
265 270 275TTG ATT GAG CAA TAC ATC CAG TTT TTA GCG GAT AGC CGT TTG AGT AAG 978Leu Ile Glu Gln Tyr Ile Gln Phe Leu Ala Asp Ser Arg Leu Ser Lys
280 285 290GTG GGC ATC GCT AAA GTT TAT GGC GTC CAA CAC CCC ATT AAA TGG GTA 1026Val Gly Ile Ala Lys Val Tyr Gly Val Gln His ProIle Lys Trp Val295 300 305 310GAG AGC TTT TCA AGT TTC AAT GAG CAG CGC TCT AAT TTC TTT GAG GCT 1074Glu Ser Phe Ser Ser Phe Asn Glu Gln Arg Ser Asn Phe Phe Glu Ala
315 320 325AGG GTG AGC AAT TAC GCT AAA GGG AGC GTG AGT TTT GAT GAT TTT TAAGG 1124Arg Val Ser Asn Tyr Ala Lys Gly Ser Val Ser Phe Asp Asp Phe
330 335 340GGCTTGTTTG AATAGTATTA AAAACCATTT AATGTGTGAA GAAATC 1170
(2) Sequence 692 data:
(i) sequence characteristics:
(A) length: 341 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 692: met Glu Val Ser Arg Lys Lys Ile Tyr Asn Pro Asn Ser Thr Glu Ser 151015 Val Asn Glu Arg Lys Ile Phe Gly Gly Asn Pro Thr Ser Met Phe Asp
20 25 30Leu Asn Lys Ile Lys Tyr Gln Trp Ala Asp His Leu Trp Lys Thr Met
35 40 45Leu Ala Asn Thr Trp Phe Ala Glu Glu Val Ser Met Asn Asp Asp Lys
50 55 60Arg Asp Tyr Leu Lys Leu Ser Ala Glu Glu Lys Ile Gly Tyr Asp Arg65 70 75 80Ala Leu Ala Gln Leu Ile Phe Met Asp Ser Leu Gln Ala Asn Asn Leu
85 90 95Ile Asp Asn Ile Asn Pro Phe Ile Thr Ser Pro Glu Ile Asn Leu Cys
100 105 110Leu Val Arg Gln Ala Tyr Glu Glu Ala Leu His Ser His Ala Tyr Ala
115 120 125Val Met Val Glu Ser Ile Ser Ala Asn Thr Glu Glu Ile Tyr Asp Met
130 135 140Trp Arg Asn Asp Met Gln Leu Lys Ser Lys Asn Asp Tyr Ile Ala Gln145 150 155 160Val Tyr Met Glu Leu Ala Lys Asn Pro Thr Glu Glu Asn Ile Leu Lys
165 170 175Ala Leu Phe Ala Asn Gln Ile Leu Glu Gly Ile Tyr Phe Tyr Ser Gly
180 185 190Phe Ser Tyr Phe Tyr Thr Leu Ala Arg Ser Gly Lys Met Leu Gly Ser
195 200 205Ala Gln Met Ile Arg Phe Ile Gln Arg Asp Glu Val Thr His Leu Ile
210 215 220Leu Phe Gln Asn Met Ile Asn Ala Leu Arg Asn Glu Arg Ala Asp Leu225 230 235 240Phe Thr Pro Gln Leu Ile Asn Glu Val Ile Gly Met Phe Lys Lys Ala
245 250 255Val Glu Ile Glu Ala Leu Trp Gly Asp Tyr Ile Thr Gln Gly Lys Ile
260 265 270Leu Gly Leu Thr Ser Ser Leu Ile Glu Gln Tyr Ile Gln Phe Leu Ala
275 280 285Asp Ser Arg Leu Ser Lys Val Gly Ile Ala Lys Val Tyr Gly Val Gln
290 295 300His Pro Ile Lys Trp Val Glu Ser Phe Ser Ser Phe Asn Glu Gln Arg305 310 315 320Ser Asn Phe Phe Glu Ala Arg Val Ser Asn Tyr Ala Lys Gly Ser Val
325 330 335Ser Phe Asp Asp Phe
340
(2) Sequence 693 data:
(i) sequence characteristics:
(A) length: 689 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 139...627
(D) Other information:
(xi) Description of the sequence: sequence 693: CAAAAGCTCA TTGAAGAAAC CCCGGCAGTG GTTTTAGAAG AGGGCGTGCG TGACGTTTGC 60TAGAAACAGC GATCAAGGCC GCTAAATATA TCGGCTRRTG TGGGGGCGGG GACTTTTGAA 120TTTTTGTTGG ATTCTAAC ATG AAA GAT TTT TAT TTC ATG GAG ATG AAC ACT 171
Met Lys Asp Phe Tyr Phe Met Glu Met Asn Thr
1 5 10CGT TTG CAA GTG GAA CAC ACC ATT AGC GAA ATG GTG AGC GGG TTA AAC 219Arg Leu Gln Val Glu His Thr Ile Ser Glu Met Val Ser Gly Leu Asn
15 20 25CTC ATT GAG TGG ATG ATT AAA ATC GCT CAA GGC GAA AAA TTG CCC AAG 267Leu Ile Glu Trp Met Ile Lys Ile Ala Gln Gly Glu Lys Leu Pro Lys
30 35 40CAA GAA AGC TTT TCT CTC AAA GGG CAT GCG ATA GAA TGC CGA ATC ACG 315Gln Glu Ser Phe Ser Leu Lys Gly His Ala Ile Glu Cys Arg Ile Thr
45 5055GCA GAA GAT CCT AAA AAA TTC TAC CCA AGC CCG GGC AAA ATT ACC GAA 363Ala Glu Asp Pro Lys Lys Phe Tyr Pro Ser Pro Gly Lys Ile Thr Glu60 65 70 75TGG ATC GCT CCT GGT GGG GTG AAT GTG CGC CTT GAT TCG CAC GCG CAT 411Trp Ile Ala Pro Gly Gly Val Asn Val Arg Leu Asp Ser His Ala His
80 85 90GCC AAT TAT GTC GTG CCT ACG CAC TAT GAT TCG ATG ATT GGC AAG CTC 459Ala Asn Tyr Val Val Pro Thr His Tyr Asp Ser Met Ile Gly Lys Leu
95 100 105ATT GTG TGG GGT GAA AAC AGA GAA AGA GCG ATC GCT AAG ATG AAA AGG 507Ile Val Trp Gly Glu Asn Arg Glu Arg Ala Ile Ala Lys Met Lys Arg
110 115 120GCT TTA AAG GAA TTT AAA GTA GAA GGC ATT AAA ACG ACC ATT CCT TTC 555Ala Leu Lys Glu Phe Lys Val Glu Gly Ile Lys Thr Thr Ile Pro Phe
125 130 135CAC CTT GAA ATG CTT GAA AAT GCG GAT TTC AGG CAA GCA AAA ATC CAC 603His Leu Glu Met Leu Glu Asn Ala Asp Phe Arg Gln Ala Lys Ile His140 145 150 155ACG AAG TAT TTA GAA GAA AAT TTT TAAGTTTTAA GGATTCTTTT AAGCATAGTT 657Thr Lys Tyr Leu Glu Glu Asn Phe
160TAAGGGTTTT AAGCGATCAG AAAAAGTCAG CA 689
(2) Sequence 694 data:
(i) sequence characteristics:
(A) length: 163 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 694: met Lys Asp Phe Tyr Phe Met Glu Met Asn Thr Arg Leu Gln Val Glu 151015 His Thr Ile Ser Glu Met Val Ser Gly Leu Asn Leu Ile Glu Trp Met
20 25 30Ile Lys Ile Ala Gln Gly Glu Lys Leu Pro Lys Gln Glu Ser Phe Ser
35 40 45Leu Lys Gly His Ala Ile Glu Cys Arg Ile Thr Ala Glu Asp Pro Lys
50 55 60Lys Phe Tyr Pro Ser Pro Gly Lys Ile Thr Glu Trp Ile Ala Pro Gly65 70 75 80Gly Val Asn Val Arg Leu Asp Ser His Ala His Ala Asn Tyr Val Val
85 90 95Pro Thr His Tyr Asp Ser Met Ile Gly Lys Leu Ile Val Trp Gly Glu
100 105 110Asn Arg Glu Arg Ala Ile Ala Lys Met Lys Arg Ala Leu Lys Glu Phe
115 120 125Lys Val Glu Gly Ile Lys Thr Thr Ile Pro Phe His Leu Glu Met Leu
130 135 140Glu Asn Ala Asp Phe Arg Gln Ala Lys Ile His Thr Lys Tyr Leu Glu145 150 155 160Glu Asn Phe
(2) Sequence 695 data:
(i) sequence characteristics:
(A) length: 1960 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1907
(D) Other information:
(xi) Description of the sequence: sequence 695: AACGAGTATT TGCACAATGA ACTCCAAAAG CTTTTAGAAA AAATCTCATC ATG TTC 56
Met Phe
1TAT CAC TTA ATC GCT CCT TTA AAA AAT AAA ACC CCC CCT TTA ACC TAT 104Tyr His Leu Ile Ala Pro Leu Lys Asn Lys Thr Pro Pro Leu Thr Tyr
5 10 15TTT TCT AAA GAG CAA CAC CAA AAA GGA GCG TTA GTC AAT ATC CCT TTA 152Phe Ser Lys Glu Gln His Gln Lys Gly Ala Leu Val Asn Ile Pro Leu
20 25 30AGG AAT AAA ACG CTT TTA GGC GTC GTC CTT GAA GAA GTT TCA AAA CCC 200Arg Asn Lys Thr Leu Leu Gly Val Val Leu Glu Glu Val Ser Lys Pro35 40 45 50TCT TTT GAA TGC CTA GAG CTA GAA AAA ACC CCT TAT TTT TTA CTC CCC 248Ser Phe Glu Cys Leu Glu Leu Glu Lys Thr Pro Tyr Phe Leu Leu Pro
55 60 65TTT CAA ATG GAG CTC GCT ATT TTT ATC GCT CAA TAT TAC TCA GCT AAT 296Phe Gln Met Glu Leu Ala Ile Phe Ile Ala Gln Tyr Tyr Ser Ala Asn
70 75 80CTT TCT TCA GTT TTA AGC CTT TTT GCC CCT TTT AAA GAA TGC GAT TTA 344Leu Ser Ser Val Leu Ser Leu Phe Ala Pro Phe Lys Glu Cys Asp Leu
85 90 95GTG GGG TTA GAA AAA ATT GAG CCT ATT CTT AAT ATA TTA AGC CAA ACG 392Val Gly Leu Glu Lys Ile Glu Pro Ile Leu Asn Ile Leu Ser Gln Thr
100 105 110CAA ACAAAC GCT TTA AAA GAA TTG CAA AAA CAT TCA GCA AGC TTG CTC 440Gln Thr Asn Ala Leu Lys Glu Leu Gln Lys His Ser Ala Ser Leu Leu115 120 125 130TTT GGC GAT ACG GGT AGC GGG AAA ACC GAG ATT TAT ATG CAT GCA ATC 488Phe Gly Asp Thr Gly Ser Gly Lys Thr Glu Ile Tyr Met His Ala Ile
135 140 145GCC CAA ACT TTA GAG CAA AAA AAA AGC GCT TTA TTG TTG GTG CCA GAA 536Ala Gln Thr Leu Glu Gln Lys Lys Ser Ala Leu Leu Leu Val Pro Glu
150 155 160ATC GCT CTC ACC CCT CAA ATG CAA CAA CGC CTT AAA AGG GTT TTT AAA 584Ile Ala Leu Thr Pro Gln Met Gln Gln Arg Leu Lys Arg Val Phe Lys
165 170 175GAA AAT TTA GGC TTG TGG CAT AGC AAA CTC TCT CAA AAT CAA AAA AAA 632Glu Asn Leu Gly Leu Trp His Ser Lys Leu Ser Gln Asn Gln Lys Lys
180 185 190CAA TTT TTA GAA AAG CTT TAT TCG CAA GAA ATC AAA TTA GTG GTA GGC 680Gln Phe Leu Glu Lys Leu Tyr Ser Gln Glu Ile Lys Leu Val Val Gly195 200 205 210ACA CGA AGC GCG TTG TTT TTA CCC CTT AAA GAG CTG GGT TTA ATC ATT 728Thr Arg Ser Ala Leu Phe Leu Pro Leu Lys Glu Leu Gly Leu Ile Ile
215 220 225GTA GAT GAA GAG CAT GAC TTT TCT TAT AAA TCC CAT CAA AGC CCT ATG 776Val Asp Glu Glu His Asp Phe Ser Tyr Lys Ser His Gln Ser Pro Met
230 235 240TAT AAC GCT AGG GAT TTA TGC TTG TAT TTA TCT CAT AAA TTC CCT ATT 824Tyr Asn Ala Arg Asp Leu Cys Leu Tyr Leu Ser His Lys Phe Pro Ile
245 250 255CAA GTG ATC TTA GGC TCT GCT ACG CCA AGT TTG AAT AGT TAT AAA CGC 872GlnVal Ile Leu Gly Ser Ala Thr Pro Ser Leu Asn Ser Tyr Lys Arg
260 265 270TTT AAA GAT AAG GCT TTA GTG CGC TTA AAG GGG CGC TAC ACC CCC ACG 920Phe Lys Asp Lys Ala Leu Val Arg Leu Lys Gly Arg Tyr Thr Pro Thr275 280 285 290CAA AAA AAC ATT ATT TTT GAA AAA ACC GAG CGT TTT ATC ACG CCC AAA 968Gln Lys Asn Ile Ile Phe Glu Lys Thr Glu Arg Phe Ile Thr Pro Lys
295 300 305CTC CTA GAA GCG CTA CAA CAA GTC CTA GAC AAA AAC GAG CAA GCC ATT 1016Leu Leu Glu Ala Leu Gln Gln Val Leu Asp Lys Asn Glu Gln Ala Ile
310 315 320ATT TTT GTG CCT ACA AGG GCT AAT TTC AAA ACC TTG CTG TGC CAA AGT 1064Ile Phe Val Pro Thr Arg Ala Asn Phe Lys Thr Leu Leu Cys Gln Ser
325 330 335TGT TAC AAA AGC GTT CAA TGC CCC TTT TGC AGC GTG AAT ATG AGC TTG 1112Cys Tyr Lys Ser Val Gln Cys Pro Phe Cys Ser Val Asn Met Ser Leu
340 345 350CAT TTA AAG ACC AAC AAA CTC ATG TGC CAT TAT TGC CAT TTT TCA AGC 1160His Leu Lys Thr Asn Lys Leu Met Cys His Tyr Cys His Phe Ser Ser355 360 365 370CCT ATC CCT AAA ATT TGC AGC GCG TGT CAA AGC GAA GTC TTA GTG GGT 1208Pro Ile Pro Lys Ile Cys Ser Ala Cys Gln Ser Glu Val Leu Val Gly
375 380 385AAA AGG ATA GGC ACT ATG CAA GTG CTA AAG GAA TTA GAG AGC CTT TTA 1256Lys Arg Ile Gly Thr Met Gln Val Leu Lys Glu Leu Glu Ser Leu Leu
390 395 400GAG GGG GCT AAA ATA GCG ATT TTA GAT AAA GAT CAC ACT AGC ACG CAA 1304Glu Gly Ala Lys Ile Ala Ile Leu Asp Lys Asp His Thr Ser Thr Gln
405 410 415AAA AAA CTC CAC AAT ATT TTA AAC GAT TTC AAC GCT CAA AAA ACG AAT 1352Lys Lys Leu His Asn Ile Leu Asn Asp Phe Asn Ala Gln Lys Thr Asn
420 425 430ATC TTA ATC GGC ACT CAA ATG ATA AGC AAA GGG CAT GAT TAC GCT AAA 1400Ile Leu Ile Gly Thr Gln Met Ile Ser Lys Gly His Asp Tyr Ala Lys435 440 445 450GTG AGT TTG GCG GTT GTT TTA GGC ATA GAC AAT ATC ATC AAA TCT AAT 1448Val Ser Leu Ala Val Val Leu Gly Ile Asp Asn Ile Ile Lys Ser Asn
455 460 465AGT TAT AGG GCT TTA GAA GAA GGC GTG TCG TTA CTT TAT CAA ATC GCT 1496Ser Tyr Arg Ala Leu Glu Glu Gly Val Ser Leu Leu Tyr Gln Ile Ala
470 475 480GGG AGG AGC GCT AGG CAA ATT TCT GGC CAA GTG TTC ATT CAA AGC ACC 1544Gly Arg Ser Ala Arg Gln Ile Ser Gly Gln Val Phe Ile Gln Ser Thr
485 490 495GAA ACC GAT CTG TTA GAA AAT TTC TTA GAA GAT TAT GAA GAT TTT TTA 1592Glu Thr Asp Leu Leu Glu Asn Phe Leu Glu Asp Tyr Glu Asp Phe Leu
500 505 510CAA TAC GAA TTG CAA GAA AGG TGC GAA CTC TAC CCG CCT TTT TCT AGG 1640Gln Tyr Glu Leu Gln Glu Arg Cys Glu Leu Tyr Pro Pro Phe Ser Arg515 520 525 530CTG TGT TTG TTG GAG TTT AAG CAT AAA AAC GAA GAA AAA GCC CAA CAA 1688Leu Cys Leu Leu Glu Phe Lys His Lys Asn Glu Glu Lys Ala Gln Gln
535 540 545TTG AGC CTA AAA GCC TCT CAA ACC CTT TCT TCG TGT TTA GAA AAG GGC 1736Leu Ser Leu Lys Ala Ser Gln Thr Leu Ser Ser Cys Leu Glu Lys Gly
550 555 560GTA ACG CTC TCT AAT TTC AAA GCCCCC ATT GAA AAA ATC GCT TCT TCT 1784Val Thr Leu Ser Asn Phe Lys Ala Pro Ile Glu Lys Ile Ala Ser Ser
565 570 575TAT CGC TAC CTT ATT TTA TTG CGT TCC AAA AAC CCT TTA AGC CTA ATC 1832Tyr Arg Tyr Leu Ile Leu Leu Arg Ser Lys Asn Pro Leu Ser Leu Ile
580 585 590AAA AGC GTG CAT GCG TTT TTA AAA TCC GCC CCT AGT ATC CCT TGC AGC 1880Lys Ser Val His Ala Phe Leu Lys Ser Ala Pro Ser Ile Pro Cys Ser595 600 605 610GTG AAC ATG GAT CCT GTG GAT ATT TTT TAAAAAACTC ATGTTTTATA TATTATT 1934Val Asn Met Asp Pro Val Asp Ile Phe
615TCAAAAAACT TAAGTTTTTC TGGCGA 1960
(2) Sequence 696:
(i) sequence characteristics:
(A) length: 619 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 696 data: met Phe Tyr His Leu Ile Ala Pro Leu Lys Asn Lys Thr Pro Pro Leu 151015 Thr Tyr Phe Ser Lys Glu Gln His Gln Lys Gly Ala Leu Val Asn Ile
20 25 30Pro Leu Arg Asn Lys Thr Leu Leu Gly Val Val Leu Glu Glu Val Ser
35 40 45Lys Pro Ser Phe Glu Cys Leu Glu Leu Glu Lys Thr Pro Tyr Phe Leu
50 55 60Leu Pro Phe Gln Met Glu Leu Ala Ile Phe Ile Ala Gln Tyr Tyr Ser65 70 75 80Ala Asn Leu Ser Ser Val Leu Ser Leu Phe Ala Pro Phe Lys Glu Cys
85 90 95Asp Leu Val Gly Leu alu Lys Ile Glu Pro Ile Leu Asn Ile Leu Ser
100 105 110Gln Thr Gln Thr Asn Ala Leu Lys Glu Leu Gln Lys His Ser Ala Ser
115 120 125Leu Leu Phe Gly Asp Thr Gly Ser Gly Lys Thr Glu Ile Tyr Met His
130 135 140Ala Ile Ala Gln Thr Leu Glu Gln Lys Lys Ser Ala Leu Leu Leu Val145 150 155 160Pro Glu Ile Ala Leu Thr Pro Gln Met Gln Gln Arg Leu Lys Arg Val
165 170 175Phe Lys Glu Asn Leu Gly Leu Trp His Ser Lys Leu Ser Gln Asn Gln
180 185 190Lys Lys Gln Phe Leu Glu Lys Leu Tyr Ser Gln Glu Ile Lys Leu Val
195 200 205Val Gly Thr Arg Ser Ala Leu Phe Leu Pro Leu Lys Glu Leu Gly Leu
210 215 220Ile Ile Val Asp Glu Glu His Asp Phe Ser Tyr Lys Ser His Gln Ser225 230 235 240Pro Met Tyr Asn Ala Arg Asp Leu Cys Leu Tyr Leu Ser His Lys Phe
245 250 255Pro Ile Gln Val Ile Leu Gly Ser Ala Thr Pro Ser Leu Asn Ser Tyr
260 265 270Lys Arg Phe Lys Asp Lys Ala Leu Val Arg Leu Lys Gly Arg Tyr Thr
275 280 285Pro Thr Gln Lys Asn Ile Ile Phe Glu Lys Thr Glu Arg Phe Ile Thr
290 295 300Pro Lys Leu Leu Glu Ala Leu Gln Gln Val Leu Asp Lys Asn Glu Gln305 310 315 320Ala Ile Ile Phe Val Pro Thr Arg Ala Asn Phe Lys Thr Leu Leu Cys
325 330 335Gln Ser Cys Tyr Lys Ser Val Gln Cys Pro Phe Cys Ser Val Asn Met
340 345 350Ser Leu His Leu Lys Thr Asn Lys Leu Met Cys His Tyr Cys His Phe
355 360 365Ser Ser Pro Ile Pro Lys Ile Cys Ser Ala Cys Gln Ser Glu Val Leu
370 375 380Val Gly Lys Arg Ile Gly Thr Met Gln Val Leu Lys Glu Leu Glu Ser385 390 395 400Leu Leu Glu Gly Ala Lys Ile Ala Ile Leu Asp Lys Asp His Thr Ser
405 410 415Thr Gln Lys Lys Leu His Asn Ile Leu Asn Asp Phe Asn Ala Gln Lys
420 425 430Thr Asn Ile Leu Ile Gly Thr Gln Met Ile Ser Lys Gly His Asp Tyr
435 440 445Ala Lys Val Ser Leu Ala Val Val Leu Gly Ile Asp Asn Ile Ile Lys
450 455 460Ser Asn Ser Tyr Arg Ala Leu Glu Glu Gly Val Ser Leu Leu Tyr Gln465 470 475 480Ile Ala Gly Arg Ser Ala Arg Gln Ile Ser Gly Gln Val Phe Ile Gln
485 490 495Ser Thr Glu Thr Asp Leu Leu Glu Asn Phe Leu Glu Asp Tyr Glu Asp
500 505 510Phe Leu Gln Tyr Glu Leu Gln Glu Arg Cys Glu Leu Tyr Pro Pro Phe
515 520 525Ser Arg Leu Cys Leu Leu Glu Phe Lys His Lys Asn Glu Glu Lys Ala
530 535 540Gln Gln Leu Ser Leu Lys Ala Ser Gln Thr Leu Ser Ser Cys Leu Glu545 550 555 560Lys Gly Val Thr Leu Ser Asn Phe Lys Ala Pro Ile Glu Lys Ile Ala
565 570 575Ser Ser Tyr Arg Tyr Leu Ile Leu Leu Arg Ser Lys Asn Pro Leu Ser
580 585 590Leu Ile Lys Ser Val His Ala Phe Leu Lys Ser Ala Pro Ser Ile Pro
595 600 605Cys Ser Val Asn Met Asp Pro Val Asp Ile Phe
610 615
(2) Sequence 697 data:
(i) sequence characteristics:
(A) length: 2438 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 82...2373
(D) Other information:
(xi) Description of the sequence: sequence 697: AAGATTAGCC ATGCTGACTT GCCAGATCAA TGATTTGCGC AGTTTCTTTG AAACTGATTT 60GAGAGTGTTG GAGAGCTTTT A ATG AAA CTG AGC ATT AAT GAT TTG AAT GTT 111
Met Lys Leu Ser Ile Asn Asp Leu Asn Val
1 510TTT GTC AAT ACG CCT AAA GAT ATA GCC AAA CTC TGT GAG GAT TTG AGT 159Phe Val Asn Thr Pro Lys Asp Ile Ala Lys Leu Cys Glu Asp Leu Ser
15 20 25CGC TTA GGT TTA GAA GTG GAA AGC TGT ATC CCT TGT ATC GCT CCT AAA 207Arg Leu Gly Leu Glu Val Glu Ser Cys Ile Pro Cys Ile Ala Pro Lys
30 35 40AAT GTG GTT GTG GGT AAA ATT TTA GAA AAA GCC CCC CAT AAA AAC GCT 255Asn Val Val Val Gly Lys Ile Leu Glu Lys Ala Pro His Lys Asn Ala
45 50 55GAA AAA CTC AGC GTG TGT CAA GTG GAT GTG GGT AAA GAA GTG TTG CAA 303Glu Lys Leu Ser Val Cys Gln Val Asp Val Gly Lys Glu Val Leu Gln
60 65 70ATC GTG TGT GGG GCT AAA AAT GTC GCG CCA AAC CAA TTC GTG CCA GTC 351Ile Val Cys Gly Ala Lys Asn Val Ala Pro Asn Gln Phe Val Pro Val75 80 85 90GCT TTA AAC GGG GCG CTA ATC GGC TCA ACC ACC ATC GCT AAA ACG GAG 399Ala Leu Asn Gly Ala Leu Ile Gly Ser Thr Thr Ile Ala Lys Thr Glu
95 100 105CTT AGG GGG GTT GAA AGC CAT GGC ATG ATT TGC TCT AGC ATT GAA TTA 447Leu Arg Gly Val Glu Ser His Gly Met Ile Cys Ser Ser Ile Glu Leu
110 115 120GGC TTC CCT AAA ATC AAT GAT GGC ATC TTG GAA TTA GAT GAG AGC GTT 495Gly Phe Pro Lys Ile Asn Asp Gly Ile Leu Glu Leu Asp Glu Ser Val
125 130 135GGG GAG TTG GTT TTA GGG AAA GAA TTA AAC GAA TAC GCC CCT TTC AAC 543Gly Glu Leu Val Leu Gly Lys Glu Leu Asn Glu Tyr Ala Pro Phe Asn
140 145 150ACG CAT GTT TTA GAA ATT TCA TTG ACT CCC AATCGT GGG GAT TGC TTG 591Thr His Val Leu Glu Ile Ser Leu Thr Pro Asn Arg Gly Asp Cys Leu155 160 165 170AGC GTT TTA GGT ATT GCC AGA GAA ATT AGC GCC TTT TAT CAC ACG CCC 639Ser Val Leu Gly Ile Ala Arg Glu Ile Ser Ala Phe Tyr His Thr Pro
175 180 185CTA AAG CCT ATT AAG GCT TTA AAT TTT ACG CCC AAA AGC GGT TTG ATC 687Leu Lys Pro Ile Lys Ala Leu Asn Phe Thr Pro Lys Ser Gly Leu Ile
190 195 200ACG CTT AGT GCG GGT GAA AAT ATT GAA TCG CAT CTG GCT TAT TAT TTG 735Thr Leu Ser Ala Gly Glu Asn Ile Glu Ser His Leu Ala Tyr Tyr Leu
205 210 215ATT TGC AAC CAT TCA TTA AAA ACC CCT TTA AAT ATC AAA CTT TCG CTC 783Ile Cys Asn His Ser Leu Lys Thr Pro Leu Asn Ile Lys Leu Ser Leu
220 225 230GCT CAT AAT AAT GCC TTG AGT GAG AAC GAT CTG AAC AAT TTC ATA GAA 831Ala His Asn Asn Ala Leu Ser Glu Asn Asp Leu Asn Asn Phe Ile Glu235 240 245 250TTT AGC ACG CAT TTT AGT GGG GTA ATA ATG AAC GCT TAT AGC CTA AAT 879Phe Ser Thr His Phe Ser Gly Val Ile Met Asn Ala Tyr Ser Leu Asn
255 260 265ACA ACC CCT ATG GAT TTG AGC GTG AAA AAC GAT GAA AAC AAC CTT GAA 927Thr Thr Pro Met Asp Leu Ser Val Lys Asn Asp Glu Asn Asn Leu Glu
270 275 280AGC GTT TAT ATC AAC CAT CAA AAA CGC TCC ACG ATC GCT ATC AAG CAT 975Ser Val Tyr Ile Asn His Gln Lys Arg Ser Thr Ile Ala Ile Lys His
285 290 295CAA GTT CAA AAA GAT TTG AGC GAG TGT TTG CTT TTA GAG GCA AGT TAC 1023Gln Val Gln Lys Asp Leu Ser Glu Cys Leu Leu LeuGlu Ala Ser Tyr
300 305 310ACC GAT CCG ATA AGC CTG TCT TTA AAA TTA CAC GCC CTA AAA GAT AAA 1071Thr Asp Pro Ile Ser Leu Ser Leu Lys Leu His Ala Leu Lys Asp Lys315 320 325 330ACG CTT CAA AAA GAC AAC GCC CTT ATT TAT AGA AGC GCT AGG GGG AGT 1119Thr Leu Gln Lys Asp Asn Ala Leu Ile Tyr Arg Ser Ala Arg Gly Ser
335 340 345AAC CCT AAT TTA TCA GAC GGC TTG AAT TTT TTA AGC GCT CAT TTG AAA 1167Asn Pro Asn Leu Ser Asp Gly Leu Asn Phe Leu Ser Ala His Leu Lys
350 355 360GCC ACG ATT TTA GAA AGC AAA CAA ACT GAG CAT TCT TTA AAA GAT CGC 1215Ala Thr Ile Leu Glu Ser Lys Gln Thr Glu His Ser Leu Lys Asp Arg
365 370 375ACC CTT ACA TTC CAG CTT GAA GAC ATT ACT GAA ATT TTG GGG CTT GCT 1263Thr Leu Thr Phe Gln Leu Glu Asp Ile Thr Glu Ile Leu Gly Leu Ala
380 385 390GTA GAG AAA GAA AAA ATT CAA GGC ATT TTA AAA AAT TTA GGC TTT AAA 1311Val Glu Lys Glu Lys Ile Gln Gly Ile Leu Lys Asn Leu Gly Phe Lys395 400 405 410GTC AGC GTA AAA GAG CCA AAC TCA AAA CCC CAA ATT TTA GAG GTT ATT 1359Val Ser Val Lys Glu Pro Asn Ser Lys Pro Gln Ile Leu Glu Val Ile
415 420 425GCG CCA AAT TTC AGG CAT GAC ATT AAA ACG ATC CAA GAT ATT GCT GAA 1407Ala Pro Asn Phe Arg His Asp Ile Lys Thr Ile Gln Asp Ile Ala Glu
430 435 440GAA ATT TTG CGC TTT GTA GGG ATT GAT AAT CTA GTC TCA AAG CCC CTT 1455Glu Ile Leu Arg Phe Val Gly Ile Asp Asn Leu Val Ser Lys Pro Leu
445 450 455CAT TGT GTC AGT AGC AAA AAT TCA AAC CCC AAT TAC GAC ACG CAC CGC 1503His Cys Val Ser Ser Lys Asn Ser Asn Pro Asn Tyr Asp Thr His Arg
460 465 470TTT TTT GAA AAC CTT AAA CAC AAG GCT CTC GCT TGC GGT TTT AAA GAA 1551Phe Phe Glu Asn Leu Lys His Lys Ala Leu Ala Cys Gly Phe Lys Glu475 480 485 490GTC ATT CAT TAC GTG TTT TAC TCT AAA GAA AAA CAG CAA AAA TTA GGC 1599Val Ile His Tyr Val Phe Tyr Ser Lys Glu Lys Gln Gln Lys Leu Gly
495 500 505TTT GAA GTT TTA GAA GAT CCC CTA GAA TTG CAA AAC CCT ATC ACA ACG 1647Phe Glu Val Leu Glu Asp Pro Leu Glu Leu Gln Asn Pro Ile Thr Thr
510 515 520GAG TTA AAC ACC CTA AGG ACG AGT CTT GTT TGC GGG CTT TTA GAC GCC 1695Glu Leu Asn Thr Leu Arg Thr Ser Leu Val Cys Gly Leu Leu Asp Ala
525 530 535AGT TTA AGG AAT AAA AAT TTA GGG TTT AAA AGC ATA GCC CTT TAT GAA 1743Ser Leu Arg Asn Lys Asn Leu Gly Phe Lys Ser Ile Ala Leu Tyr Glu
540 545 550AAG GGG AGC GTG TAT AAC TCT AAA AGA GAA GAA ATC CAA AAA CTA GGC 1791Lys Gly Ser Val Tyr Asn Ser Lys Arg Glu Glu Ile Gln Lys Leu Gly555 560 565 570TTT TTA ATA AGC GGC TTG CAA AAA AAA GAA AGC TAC CCT GAT ACT AAG 1839Phe Leu Ile Ser Gly Leu Gln Lys Lys Glu Ser Tyr Pro Asp Thr Lys
575 580 585GGC AAG GCT TGG GAT TTT TAC TCT TTT GCC GAA TGC GTT TCA AAA GTT 1887Gly Lys Ala Trp Asp Phe Tyr Ser Phe Ala Glu Cys Val Ser Lys Val
590 595 600ATA GGG GAT TTC AGC TTG GAA AAA CTA ACC ACT CAA ACC CCC ATT AAC 1935Ile Gly Asp Phe Ser Leu Glu Lys Leu Thr Thr Gln Thr Pro Ile Asn
605 610 615CAC CCC TAC CAG AGC GCT AAA ATC ATT CAA AAT CAT GAA ATC ATA GGC 1983His Pro Tyr Gln Ser Ala Lys Ile Ile Gln Asn His Glu Ile Ile Gly
620 625 630GTG ATC GCT AAA ATC CAC CCT AAA GTG ATC CAG GAA TTG GAT TTG TTT 2031Val Ile Ala Lys Ile His Pro Lys Val Ile Gln Glu Leu Asp Leu Phe635 640 645 650GAA AGC TAT TAC GCT GAG ATA GAC GCT TTT AAA CTC AAA CGC CCT GCT 2079Glu Ser Tyr Tyr Ala Glu Ile Asp Ala Phe Lys Leu Lys Arg Pro Ala
655 660 665ATG CTA TTA AAA CCC TTT AGC ATT TAT CCT AGC AGT GTT AGG GAT TTG 2127Met Leu Leu Lys Pro Phe Ser Ile Tyr Pro Ser Ser Val Arg Asp Leu
670 675 680ACT CTC ATC ATT GAT GAG AAT ACC GCT TTT AGT GGG ATT AAA AAA GCC 2175Thr Leu Ile Ile Asp Glu Asn Thr Ala Phe Ser Gly Ile Lys Lys Ala
685 690 695CTA AAG GAC GCT CAA ATC CCT AAT TTA AGC GAG ATT CTA CCC CTT GAT 2223Leu Lys Asp Ala Gln Ile Pro Asn Leu Ser Glu Ile Leu Pro Leu Asp
700 705 710ATT TTT AAA GAA AGT AAT AAT TCC ATA GCC TTA AGC GTG CGT TGC GTG 2271Ile Phe Lys Glu Ser Asn Asn Ser Ile Ala Leu Ser Val Arg Cys Val715 720 725 730ATC CAT TCT TTA GAA AAA ACC CTG AAT GAT GAA GAG GTC AAT TCA GCC 2319Ile His Ser Leu Glu Lys Thr Leu Asn Asp Glu Glu Val Asn Ser Ala
735 740 745GTG CAA AAA GCA CTT GAA ATT TTA GAA AAA GAA TTT AAC GCC CGC CTT 2367Val Gln Lys Ala Leu Glu Ile Leu Glu Lys Glu Phe Asn Ala Arg Leu
750 755 760AAA GGA TAATATAAAG GATAATATGT GATAGAGCTT GACATTAACG CTAGCGATAA AT 2425Lys GlyCGCTCTCACA CAG 2438
(2) Sequence 698:
(i) sequence characteristics:
(A) length: 764 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 698 data: met Lys Leu Ser Ile Asn Asp Leu Asn Val Phe Val Asn Thr Pro Lys 151015 Asp Ile Ala Lys Leu Cys Glu Asp Leu Ser Arg Leu Gly Leu Glu Val
20 25 30Glu Ser Cys Ile Pro Cys Ile Ala Pro Lys Asn Val Val ValGly Lys
35 40 45Ile Leu Glu Lys Ala Pro His Lys Asn Ala Glu Lys Leu Ser Val Cys
50 55 60Gln Val Asp Val Gly Lys Glu Val Leu Gln Ile Val Cys Gly Ala Lys65 70 75 80Asn Val Ala Pro Asn Gln Phe Val Pro Val Ala Leu Asn Gly Ala Leu
85 90 95Ile Gly Ser Thr Thr Ile Ala Lys Thr Glu Leu Arg Gly Val Glu Ser
100 105 110His Gly Met Ile Cys Ser Ser Ile Glu Leu Gly Phe Pro Lys Ile Asn
115 120 125Asp Gly Ile Leu Glu Leu Asp Glu Ser Val Gly Glu Leu Val Leu Gly
130 135 140Lys Glu Leu Asn Glu Tyr Ala Pro Phe Asn Thr His Val Leu Glu Ile145 150 155 160Ser Leu Thr Pro Asn Arg Gly Asp Cys Leu Ser Val Leu Gly Ile Ala
165 170 175Arg Glu Ile Ser Ala Phe Tyr His Thr Pro Leu Lys Pro Ile Lys Ala
180 185 190Leu Asn Phe Thr Pro Lys Ser Gly Leu Ile Thr Leu Ser Ala Gly Glu
195 200 205Asn Ile Glu Ser His Leu Ala Tyr Tyr Leu Ile Cys Asn His Ser Leu
210 215 220Lys Thr Pro Leu Asn Ile Lys Leu Ser Leu Ala His Asn Asn Ala Leu225 230 235 240Ser Glu Asn Asp Leu Asn Asn Phe Ile Glu Phe Ser Thr His Phe Ser
245 250 255Gly Val Ile Met Asn Ala Tyr Ser Leu Asn Thr Thr Pro Met Asp Leu
260 265 270Ser Val Lys Asn Asp Glu Asn Asn Leu Glu Ser Val Tyr Ile Asn His
275 280 285Gln Lys Arg Ser Thr Ile Ala Ile Lys His Gln Val Gln Lys Asp Leu
290 295 300Ser Glu Cys Leu Leu Leu Glu Ala Ser Tyr Thr Asp Pro Ile Ser Leu305 310 315 320Ser Leu Lys Leu His Ala Leu Lys Asp Lys Thr Leu Gln Lys Asp Asn
325 330 335Ala Leu Ile Tyr Arg Ser Ala Arg Gly Ser Asn Pro Asn Leu Ser Asp
340 345 350Gly Leu Asn Phe Leu Ser Ala His Leu Lys Ala Thr Ile Leu Glu Ser
355 360 365Lys Gln Thr Glu His Ser Leu Lys Asp Arg Thr Leu Thr Phe Gln Leu
370 375 380Glu Asp Ile Thr Glu Ile Leu Gly Leu Ala Val Glu Lys Glu Lys Ile385 390 395 400Gln Gly Ile Leu Lys Asn Leu Gly Phe Lys Val Ser Val Lys Glu Pro
405 410 415Asn Ser Lys Pro Gln Ile Leu Glu Val Ile Ala Pro Asn Phe Arg His
420 425 430Asp Ile Lys Thr Ile Gln Asp Ile Ala Glu Glu Ile Leu Arg Phe Val
435 440 445Gly Ile Asp Asn Leu Val Ser Lys Pro Leu His Cys Val Ser Ser Lys
450 455 460Asn Ser Asn Pro Asn Tyr Asp Thr His Arg Phe Phe Glu Asn Leu Lys465 470 475 480His Lys Ala Leu Ala Cys Gly Phe Lys Glu Val Ile His Tyr Val Phe
485 490 495Tyr Ser Lys Glu Lys Gln Gln Lys Leu Gly Phe Glu Val Leu Glu Asp
500 505 510Pro Leu Glu Leu Gln Asn Pro Ile Thr Thr Glu Leu Asn Thr Leu Arg
515 520 525Thr Ser Leu Val Cys Gly Leu Leu Asp Ala Ser Leu Arg Asn Lys Asn
530 535 540Leu Gly Phe Lys Ser Ile Ala Leu Tyr Glu Lys Gly Ser Val Tyr Asn545 550 555 560Ser Lys Arg Glu Glu Ile Gln Lys Leu Gly Phe Leu Ile Ser Gly Leu
565 570 575Gln Lys Lys Glu Ser Tyr Pro Asp Thr Lys Gly Lys Ala Trp Asp Phe
580 585 590Tyr Ser Phe Ala Glu Cys Val Ser Lys Val Ile Gly Asp Phe Ser Leu
595 600 605Glu Lys Leu Thr Thr Gln Thr Pro Ile Asn His Pro Tyr Gln Ser Ala
610 615 620Lys Ile Ile Gln Asn His Glu Ile Ile Gly Val Ile Ala Lys Ile His625 630 635 640Pro Lys Val Ile Gln Glu Leu Asp Leu Phe Glu Ser Tyr Tyr Ala Glu
645 650 655Ile Asp Ala Phe Lys Leu Lys Arg Pro Ala Met Leu Leu Lys Pro Phe
660 665 670Ser Ile Tyr Pro Ser Ser Val Arg Asp Leu Thr Leu Ile Ile Asp Glu
675 680 685Asn Thr Ala Phe Ser Gly Ile Lys Lys Ala Leu Lys Asp Ala Gln Ile
690 695 700Pro Asn Leu Ser Glu Ile Leu Pro Leu Asp Ile Phe Lys Glu Ser Asn705 710 715 720Asn Ser Ile Ala Leu Ser Val Arg Cys Val Ile His Ser Leu Glu Lys
725 730 735Thr Leu Asn Asp Glu Glu Val Asn Ser Ala Val Gln Lys Ala Leu Glu
740 745 750Ile Leu Glu Lys Glu Phe Asn Ala Arg Leu Lys Gly
755 760
(2) Sequence 699 data:
(i) sequence characteristics:
(A) length: 1097 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 492...1040
(D) Other information:
(xi) Description of the sequence: sequence 699: TTTCTTTTAT TAAAGTTGTA TTATAGCTTT TTAAAAATAA AATATAAGGA TCGTTATTGC 60ACACCTTAAT AGAGCGATTA GAAAAGGTTA CTAATAGCAA AGAGTTAGAA GAAGCGCGCT 120TGAATGCTTT GGGTAAAAAA GGGGTTTTTG CGGATAAATT CAACCAGCTC AAACATCTGA 180ACGGCGAAGA AAAAAACGCC TTTGCTAAAG AAATCCACCA TTATAAACAA GCGTTTGAAA 240AAGCCTTTGA ATGGAAAAAA AAGGCTATTA TAGAGCTTGA ATTAGAAGAA CGCTTGAAAA 300AAGAAAAAAT TGATGTGAGC TTGTTTAACG CTATCAAAAC AAGCTCTTCT CACCCTTTAA 360ACTACACTAA AAATAAAATC ATTGAATTTT TCACCCCATT AGGATACAAG CTTGAAATCG 420GCTCTTTAGT GGAAGATGAT TTCCATAATT TCAGCGCTTT AAACTTGCCC CCTTACCATC 480CTGCAAGAGA C ATG CAA GAC ACT TTT TAT TTT AAA GAT CAC AAG CTT TTA 530
Met Gln Asp Thr Phe Tyr Phe Lys Asp His Lys Leu Leu
1 5 10AGG ACC CAC ACT TCG CCC GTG CAA ATC CAC ACC ATG CAA GAA CAA ACC 578Arg Thr His Thr Ser Pro Val Gln Ile His Thr Met Gln Glu Gln Thr
15 20 25CCA CCC ATT AAG ATG ATT TGT TTA GGC GAA ACC TTT AGG CGC GAT TAT 626Pro Pro Ile Lys Met Ile Cys Leu Gly Glu Thr Phe Arg Arg Asp Tyr30 35 40 45GAT TTG ACC CAC ACG CCC ATG TTC CAC CAA ATT GAA GGG CTT GTC GTG 674Asp Leu Thr His Thr Pro Met Phe His Gln Ile Glu Gly Leu Val Val
50 55 60GAT CAA AAA GGG AAT ATC CGT TTC ACA CAT TTA AAA GGT GTG ATC GAA 722Asp Gln Lys Gly Asn Ile Arg Phe Thr His Leu Lys Gly Val Ile Glu
6570 75GAC TTT TTG CAT TAT TTC TTT GGG GGC GTG AAG TTA AGG TGG CGC TCT 770Asp Phe Leu His Tyr Phe Phe Gly Gly Val Lys Leu Arg Trp Arg Ser
80 85 90AGC TTT TTC CCT TTC ACA GAG CCA AGC GCT GAA GTG GAT ATT AGT TGC 818Ser Phe Phe Pro Phe Thr Glu Pro Ser Ala Glu Val Asp Ile Ser Cys
95 100 105GTG TTT TGC AAG CAA GAA GGC TGT AGG GTT TGC TCG CAC ACA GGC TGG 866Val Phe Cys Lys Gln Glu Gly Cys Arg Val Cys Ser His Thr Gly Trp110 115 120 125TTA GAA GTG TTG GGC TGT GGC ATG GTC AAT AAT GCG GTG TTT GAA GCC 914Leu Glu Val Leu Gly Cys Gly Met Val Asn Asn Ala Val Phe Glu Ala
130 135 140ATA GGG TAT GAG AAT GTG AGC GGG TTT GCT TTT GGC ATG GGG ATT GAA 962Ile Gly Tyr Glu Asn Val Ser Gly Phe Ala Phe Gly Met Gly Ile Glu
145 150 155AGA TTA GCC ATG CTG ACT TGC CAG ATC AAT GAT TTG CGC AGT TTC TTT 1010Arg Leu Ala Met Leu Thr Cys Gln Ile Asn Asp Leu Arg Ser Phe Phe
160 165 170GAA ACT GAT TTG AGA GTG TTG GAG AGC TTT TAATGAAACT GAGCATTAAT GAT 1063Glu Thr Asp Leu Arg Val Leu Glu Ser Phe
175 180TTGAATGTTT TTGTCAATAC GCCTAAAGAT ATAG 1097
(2) Sequence 700 data:
(i) sequence characteristics:
(A) length: 183 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 700: met Gln Asp Thr Phe Tyr Phe Lys Asp His Lys Leu Leu Arg Thr His 151015 Thr Ser Pro Val Gln Ile His Thr Met Gln Glu Gln Thr Pro Pro Ile
20 25 30Lys Met Ile Cys Leu Gly Glu Thr Phe Arg Arg Asp Tyr Asp Leu Thr
35 40 45His Thr Pro Met Phe His Gln Ile Glu Gly Leu Val Val Asp Gln Lys
50 55 60Gly Asn Ile Arg Phe Thr His Leu Lys Gly Val Ile Glu Asp Phe Leu65 70 75 80His Tyr Phe Phe Gly Gly Val Lys Leu Arg Trp Arg Ser Ser Phe Phe
85 90 95Pro Phe Thr Glu Pro Ser Ala Glu Val Asp Ile Ser Cys Val Phe Cys
100 105 110Lys Gln Glu Gly Cys Arg Val Cys Ser His Thr Gly Trp Leu Glu Val
115 120 125Leu Gly Cys Gly Met Val Asn Asn Ala Val Phe Glu Ala Ile Gly Tyr
130 135 140Glu Asn Val Ser Gly Phe Ala Phe Gly Met Gly Ile Glu Arg Leu Ala145 150 155 160Met Leu Thr Cys Gln Ile Asn Asp Leu Arg Ser Phe Phe Glu Thr Asp
165 170 175Leu Arg Val Leu Glu Ser Phe
180
(2) Sequence 701 data:
(i) sequence characteristics:
(A) length: 517 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...464
(D) Other information:
(xi) Description of the sequence: sequence 701: TATTGACTTT CATAGAAAGT ATTTTAACCT CTTTTTGTTA AAATAGGTCT ATG AAA 56
Met Lys
1AAA ATT GAT GAT ATG AGA CAC GGA AGA CAT TGT GTT TTT TTA ATG CAT 104Lys Ile Asp Asp Met Arg His Gly Arg His Cys Val Phe Leu Met His
5 10 15GTG CAT TTT GTA TTT GTT ACT AAA TAC AGG CGT TCA GCA TTC AAT AAG 152Val His Phe Val Phe Val Thr Lys Tyr Arg Arg Ser Ala Phe Asn Lys
20 25 30GAA GTG ATA GAT TTT TTA GGA TCG GTG TTT GCC AAA GTG TGT AAG GAC 200Glu Val Ile Asp Phe Leu Gly Ser Val Phe Ala Lys Val Cys Lys Asp35 40 45 50TTT GAG AGC GAA TTG GTA GAA TTT GAT GGG GAG AGC GAT CAT GTG CAT 248Phe Glu Ser Glu Leu Val Glu Phe Asp Gly Glu Ser Asp His Val His
55 60 65TTG CTT ATC AAC TAC CCT CCA AAA GTG AGC GTG AGT AAG TTA GTT AAT 296Leu Leu Ile Asn Tyr Pro Pro Lys Val Ser Val Ser Lys Leu Val Asn
70 75 80TCT TTA AAA GGC GTT AGC AGT CGT TTG ACT AGA CAA CAC CAT TTC AAA 344Ser Leu Lys Gly Val Ser Ser Arg Leu Thr Arg Gln His His Phe Lys
85 90 95AGC GTT GAA GCT AGT TTG TGG GGG AAG CAT TTA TGG TCG CCT AGT TAT 392Ser Val Glu Ala Ser Leu Trp Gly Lys His Leu Trp Ser Pro Ser Tyr
100 105 110TTC GCT GGG AGT TGT GGG GAC GCG CCT TTA GAG ATG ATT AAG CAA TAC 440Phe Ala Gly Ser Cys Gly Asp Ala Pro Leu Glu Met Ile Lys Gln Tyr115 120 125 130ATA CAA GAT CAA GAA ACA CCG CAT TAAATTAGCT AACTTTGATT TTTAAGTAGA 494Ile Gln Asp Gln Glu Thr Pro His
135ACGCGCTAAA AAGCGAATGG ATC 517
(2) Sequence 702 data:
(i) sequence characteristics:
(A) length: degree: 138 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 702: met Lys Lys Ile Asp Asp Met Arg His Gly Arg His Cys Val Phe Leu 151015 Met His Val His Phe Val Phe Val Thr Lys Tyr Arg Arg Ser Ala Phe
20 25 30Asn Lys Glu Val Ile Asp Phe Leu Gly Ser Val Phe Ala Lys Val Cys
35 40 45Lys Asp Phe Glu Ser Glu Leu Val Glu Phe Asp Gly Glu Ser Asp His
50 55 60Val His Leu Leu Ile Asn Tyr Pro Pro Lys Val Ser Val Ser Lys Leu65 70 75 80Val Asn Ser Leu Lys Gly Val Ser Ser Arg Leu Thr Arg Gln His His
85 90 95Phe Lys Ser Val Glu Ala Ser Leu Trp Gly Lys His Leu Trp Ser Pro
100 105 110Ser Tyr Phe Ala Gly Ser Cys Gly Asp Ala Pro Leu Glu Met Ile Lys
115 120 125Gln Tyr Ile Gln Asp Gln Glu Thr Pro His
130 135
(2) Sequence 703 data:
(i) sequence characteristics:
(A) length: 1786 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...1733
(D) Other information:
(xi) Description of the sequence: sequence 703: AAAAATAACC CCCATCTCTT TAAAACCTTA TCATAATGAA AGGATAAAAA ATG CAA 56
Met Gln
1GAA GTC CAT GAT TAT GGG ATT AAA TTT TGG AGC AAT AAC GAA TTT AAG 104Glu Val His Asp Tyr Gly Ile Lys Phe Trp Ser Asn Asn Glu Phe Lys
5 10 15ATA GAA AAA GGC TTG GTT AAA GTC TGT CAT GGT AAA AAC CCC TCG CTT 152Ile Glu Lys Gly Leu Val Lys Val Cys His Gly Lys Asn Pro Ser Leu
20 25 30TTA GAA ATC GTT CAA AGC GTG CGC GAT AAG GGC TAT AGA GGA CCT TTG 200Leu Glu Ile Val Gln Ser Val Arg Asp Lys Gly Tyr Arg Gly Pro Leu35 40 45 50TTG GTG CGA TTC CCC CAT TTG GTG CAA AAA CAA ATC AAA AGC CTG TTT 248Leu Val Arg Phe Pro His Leu Val Gln Lys Gln Ile Lys Ser Leu Phe
55 60 65GAT GCG TTT TCT TCA GCG ATT AAA GAG TAT CAA TAC AGC GGG GCT TTT 296Asp Ala Phe Ser Ser Ala Ile Lys Glu Tyr Gln Tyr Ser Gly Ala Phe
70 75 80AAG GCG GTT TTC CCT TTA AAA GTC AAT CAA ATG CCC TCG TTT GTT TTC 344Lys Ala Val Phe Pro Leu Lys Val Asn Gln Met Pro Ser Phe Val Phe
85 90 95CCT TTA GTG CAG GGG GCT AAG GGT TTG AAT TAC GGA TTA GAG GCT GGG 392Pro Leu Val Gln Gly Ala Lys Gly Leu Asn Tyr Gly Leu Glu Ala Gly
100 105 110AGC AAG TCT GAA CTC ATC ATC GCA ATG AGT TAC ACT AAC CCT AAA GCC 440Ser Lys Ser Glu Leu Ile Ile Ala Met Ser Tyr Thr Asn Pro Lys Ala115 120 125 130CCT ATC ACC GTG AAT GGC TTT AAA GAC AAA GAA ATG ATT GAG CTT GGC 488Pro Ile Thr Val Asn Gly Phe Lys Asp Lys Glu Met Ile Glu Leu Gly
135 140 145TTT ATC GCT AAA AGC ATG CAG CAT GAG ATC ACT TTA ACG ATT GAG GGT 536Phe Ile Ala Lys Ser Met Gln His Glu Ile Thr Leu Thr Ile Glu Gly
150 155 160TTG AAT GAA TTG AAA ACC ATT ATC GCC GTG GCT AAA CAA AAC GAG TTT 584Leu Asn Glu Leu Lys Thr Ile Ile Ala Val Ala Lys Gln Asn Glu Phe
165 170 175TTA GCC TGC CCT AAA ATT GGC ATC CGC ATC CGT TTG CAC AGC ACT GGC 632Leu Ala Cys Pro Lys Ile Gly Ile Arg Ile Arg Leu His Ser Thr Gly
180 185 190ACT GGC GTT TGG GCA AAG AGT GGG GGG ATC AAT TCT AAA TTT GGT CTT 680Thr Gly Val Trp Ala Lys Ser Gly Gly Ile Asn Ser Lys Phe Gly Leu195 200 205 210AGC AGC ACT GAA GTT TTA GAG GCG ATG CGC CTT TTA GAA GAA AAC GAC 728Ser Ser Thr Glu Val Leu Glu Ala Met Arg Leu Leu Glu Glu Asn Asp
215 220 225TTG TTA GAG CAT TTC CAC ATG ATA CAT TTC CAT ATA GGC TCT CAA ATC 776Leu Leu Glu His Phe His Met Ile His Phe His Ile Gly Ser Gln Ile
230 235 240AGC GAT ATT TCG CCC TTA AAA AAG GCT TTA AGA GAA GCG GGT AAC TTG 824Ser Asp Ile Ser Pro Leu Lys Lys Ala Leu Arg Glu Ala Gly Asn Leu
245 250 255TAT GCA GAA TTG CGT AAA ATG GGC GCT AAA AAT CTT AAT AGC GTG AAT 872Tyr Ala Glu Leu Arg Lys Met Gly Ala Lys Asn Leu Asn Ser Val Asn
260 265 270ATT GGA GGG GGG TTA GCC GTA GAA TAC ACC CAA CAC AAG CAC CAC CAA 920Ile Gly Gly Gly Leu Ala Val Glu Tyr Thr Gln His Lys His His Gln275 280 285 290GAC AAA AAC TAC ACT TTA GAG GAA TTC AGC GCT GAT GTG GTG TTT TTA 968Asp Lys Asn Tyr Thr Leu Glu Glu Phe Ser Ala Asp Val Val Phe Leu
295 300 305TTG AGA GAA ATT GTG AAA AAT AAG CAG GAA ATC GAG CCG GAC ATT TTC 1016Leu Arg Glu Ile Val Lys Asn Lys Gln Glu Ile Glu Pro Asp Ile Phe
310 315 320ATT GAA TCA GGC CGT TAT ATT TCC GCT AAC CAT GCC GTT TTA GTG GCC 1064Ile Glu Ser Gly Arg Tyr Ile Ser Ala Asn His Ala Val Leu Val Ala
325 330335CCG GTG TTA GAA TTG TTT TCG CAT GAA TAC AAT GAA AAA TCC CTA AAA 1112Pro Val Leu Glu Leu Phe Ser His Glu Tyr Asn Glu Lys Ser Leu Lys
340 345 350ATC AAA GAA AAT AAT AAC CCC CCT TTG ATT GAT GAA ATG CTA GAC TTG 1160Ile Lys Glu Asn Asn Asn Pro Pro Leu Ile Asp Glu Met Leu Asp Leu355 360 365 370CTC GCT AAT ATC AAT GAA AAA AAC GCC ATT GAA TAC TTG CAT GAT AGT 1208Leu Ala Asn Ile Asn Glu Lys Asn Ala Ile Glu Tyr Leu His Asp Ser
375 380 385TTT GAT CAC ACC GAG TCG CTA TTC ACG CTT TTT GAT CTG GGC TAT ATT 1256Phe Asp His Thr Glu Ser Leu Phe Thr Leu Phe Asp Leu Gly Tyr Ile
390 395 400GAT TTG ATT GAC AGG AGC AAC ACT GAA GTT TTA GCC CAT TTG ATC GTC 1304Asp Leu Ile Asp Arg Ser Asn Thr Glu Val Leu Ala His Leu Ile Val
405 410 415AAA AAA GCG GTG CAA TTG CTT TAT GTT AAG GAT CAT AAC GAT ATT TTA 1352Lys Lys Ala Val Gln Leu Leu Tyr Val Lys Asp His Asn Asp Ile Leu
420 425 430CGC ATT CAA GAG CAG GTC CAA GAG CGC TAT TTA TTG AAT TGC TCG TTT 1400Arg Ile Gln Glu Gln Val Gln Glu Arg Tyr Leu Leu Asn Cys Ser Phe435 440 445 450TTC CAA AGC TTG CCG GAT TAT TGG GGC TTG AGA CAG AAT TTC CCG GTC 1448Phe Gln Ser Leu Pro Asp Tyr Trp Gly Leu Arg Gln Asn Phe Pro Val
455 460 465ATG CCC TTG AAT AAA TTA GAT GAA AAG CCC ACC AGG AGT GCG AGC TTG 1496Met Pro Leu Asn Lys Leu Asp Glu Lys Pro Thr Arg Ser Ala Ser Leu
470 475 480TGG GAT ATT ACT TGC GAT AGC GAT GGG GAA ATC GCT TTT GAT TCC ACG 1544Trp Asp Ile Thr Cys Asp Ser Asp Gly Glu Ile Ala Phe Asp Ser Thr
485 490 495AAG CCC TTG TTT TTG CAC GAT ATA GAT ATA GAT GAA GAA GAA TAC TTT 1592Lys Pro Leu Phe Leu His Asp Ile Asp Ile Asp Glu Glu Glu Tyr Phe
500 505 510TTA GCG TTC TTT TTA GTG GGA GCG TAT CAA GAA GTT TTA GGC ATG AAA 1640Leu Ala Phe Phe Leu Val Gly Ala Tyr Gln Glu Val Leu Gly Met Lys515 520 525 530CAC AAT TTA TTC ACG CAC CTA CGG AAT TTA GCG TGG TTT TTG ATG AAA 1688His Asn Leu Phe Thr His Leu Arg Asn Leu Ala Trp Phe Leu Met Lys
535 540 545AAG GCG ATT ATG AAG TGG AAG ATA TTT GTG AAG CCC AAA CGA TTT TAGAT 1738Lys Ala Ile Met Lys Trp Lys Ile Phe Val Lys Pro Lys Arg Phe
550 555 560GTGCTAGACG ATTTAGACTA TGACACTAAA GAGATCGAGC GCCTTTTA 1786
(2) Sequence 704 data:
(i) sequence characteristics:
(A) length: 561 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 704: met Gln Glu Val His Asp Tyr Gly Ile Lys Phe Trp Ser Asn Asn Glu 151015 Phe Lys Ile Glu Lys Gly Leu Val Lys Val Cys His Gly Lys Asn Pro
20 25 30Ser Leu Leu Glu Ile Val Gln Ser Val Arg Asp Lys Gly Tyr Arg Gly
35 4045Pro Leu Leu Val Arg Phe Pro His Leu Val Gln Lys Gln Ile Lys Ser
50 55 60Leu Phe Asp Ala Phe Ser Ser Ala Ile Lys Glu Tyr Gln Tyr Ser Gly65 70 75 80Ala Phe Lys Ala Val Phe Pro Leu Lys Val Asn Gln Met Pro Ser Phe
85 90 95Val Phe Pro Leu Val Gln Gly Ala Lys Gly Leu Asn Tyr Gly Leu Glu
100 105 110Ala Gly Ser Lys Ser Glu Leu Ile Ile Ala Met Ser Tyr Thr Asn Pro
115 120 125Lys Ala Pro Ile Thr Val Asn Gly Phe Lys Asp Lys Glu Met Ile Glu
130 135 140Leu Gly Phe Ile Ala Lys Ser Met Gln His Glu Ile Thr Leu Thr Ile145 150 155 160Glu Gly Leu Asn Glu Leu Lys Thr Ile Ile Ala Val Ala Lys Gln Asn
165 170 175Glu Phe Leu Ala Cys Pro Lys Ile Gly Ile Arg Ile Arg Leu His Ser
180 185 190Thr Gly Thr Gly Val Trp Ala Lys Ser Gly Gly Ile Asn Ser Lys Phe
195 200 205Gly Leu Ser Ser Thr Glu Val Leu Glu Ala Met Arg Leu Leu Glu Glu
210 215 220Asn Asp Leu Leu Glu His Phe His Met Ile His Phe His Ile Gly Ser225 230 235 240Gln Ile Ser Asp Ile Ser Pro Leu Lys Lys Ala Leu Arg Glu Ala Gly
245 250 255Asn Leu Tyr Ala Glu Leu Arg Lys Met Gly Ala Lys Asn Leu Asn Ser
260265 270Val Asn Ile Gly Gly Gly Leu Ala Val Glu Tyr Thr Gln His Lys His
275 280 285His Gln Asp Lys Asn Tyr Thr Leu Glu Glu Phe Ser Ala Asp Val Val
290 295 300Phe Leu Leu Arg Glu Ile Val Lys Asn Lys Gln Glu Ile Glu Pro Asp305 310 315 320Ile Phe Ile Glu Ser Gly Arg Tyr Ile Ser Ala Asn His Ala Val Leu
325 330 335Val Ala Pro Val Leu Glu Leu Phe Ser His Glu Tyr Asn Glu Lys Ser
340 345 350Leu Lys Ile Lys Glu Asn Asn Asn Pro Pro Leu Ile Asp Glu Met Leu
355 360 365Asp Leu Leu Ala Asn Ile Asn Glu Lys Asn Ala Ile Glu Tyr Leu His
370 375 380Asp Ser Phe Asp His Thr Glu Ser Leu Phe Thr Leu Phe Asp Leu Gly385 390 395 400Tyr Ile Asp Leu Ile Asp Arg Ser Ash Thr Glu Val Leu Ala His Leu
405 410 415Ile Val Lys Lys Ala Val Gln Leu Leu Tyr Val Lys Asp His Asn Asp
420 425 430Ile Leu Arg Ile Gln Glu Gln Val Gln Glu Arg Tyr Leu Leu Asn Cys
435 440 445Ser Phe Phe Gln Ser Leu Pro Asp Tyr Trp Gly Leu Arg Gln Asn Phe
450 455 460Pro Val Met Pro Leu Asn Lys Leu Asp Glu Lys Pro Thr Arg Ser Ala465 470 475 480Ser Leu Trp Asp Ile Thr Cys Asp Ser Asp Gly Glu Ile Ala Phe Asp
485490 495Ser Thr Lys Pro Leu Phe Leu His Asp Ile Asp Ile Asp Glu Glu Glu
500 505 510Tyr Phe Leu Ala Phe Phe Leu Val Gly Ala Tyr Gln Glu Val Leu Gly
515 520 525Met Lys His Asn Leu Phe Thr His Leu Arg Asn Leu Ala Trp Phe Leu
530 535 540Met Lys Lys Ala Ile Met Lys Trp Lys Ile Phe Val Lys Pro Lys Arg545 550 555 560Phe
(2) Sequence 705 data:
(i) sequence characteristics:
(A) length: 676 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...623
(D) Other information:
(xi) Description of the sequence: sequence 705: TTAAAGAGGA TAAAGAGAAT AGTGATAGCG ATAATGATAC TGCAGACACG ATG GAT 56
Met Asp
1GAA GTC TTA AAA GAG ATT TTA TCA AGT TAT CAA AAA AGA GCT TTA AAA 104Glu Val Leu Lys Glu Ile Leu Ser Ser Tyr Gln Lys Arg Ala Leu Lys
5 10 15TTA ACC AAA AGA GTT AGA AAG AAG ATT TTT AAG AAT GAT CCC ACA GAA 152Leu Thr Lys Arg Val Arg Lys Lys Ile Phe Lys Asn Asp Pro Thr Glu
20 25 30AAT CAA AAA AAA GCC ATA AAG ATC GCT CTA AAT ACC CCT GAT ATT GCT 200Asn Gln Lys Lys Ala Ile Lys Ile Ala Leu Asn Thr Pro Asp Ile Ala35 40 45 50ATT ATC CAA GGG CCT CCT GGA ACG GGC AAA ACC ACT GTG ATC AAT GCC 248Ile Ile Gln Gly Pro Pro Gly Thr Gly Lys Thr Thr Val Ile Asn Ala
55 60 65ATT TGT GAG AGA TTG TTT GAA GAA TAC CCT AAG GAT AAA AAT ATC AAG 296Ile Cys Glu Arg Leu Phe Glu Glu Tyr Pro Lys Asp Lys Asn Ile Lys
70 75 80GGG CAA ATT TTA CTG TGC GCT CAA GGG CAT GAT GCG ACT AAC AAT GCG 344Gly Gln Ile Leu Leu Cys Ala Gln Gly His Asp Ala Thr Asn Asn Ala
85 90 95CGT GAG CGC ATC AAA GTA GGG GGA TTG CCC ACT TTT AAA TTT GGT GCT 392Arg Glu Arg Ile Lys Val Gly Gly Leu Pro Thr Phe Lys Phe Gly Ala
100 105 110AAA AAA AAT GCT AAA GAA GAA CAA TAC AAG CAA GAT GAA AGA TTG AAT 440Lys Lys Asn Ala Lys Glu Glu Gln Tyr Lys Gln Asp Glu Arg Leu Asn115 120 125 130GAG CGA TTG AGA GAG TTT GCT GAA ACG CTC ATA GAA AGC GTG AGA AAA 488Glu Arg Leu Arg Glu Phe Ala Glu Thr Leu Ile Glu Ser Val Arg Lys
135 140 145AAA CTG CAA AAA TTA GGG GAT TAT GAA AAT ATA GAA AAA ATT TTG GAT 536Lys Leu Gln Lys Leu Gly Asp Tyr Glu Asn Ile Glu Lys Ile Leu Asp
150 155 160TTA GAA GAA GCC CTT AGA CGC TAC TAT AGT TCG CCT ATC AGT GAA TTG 584Leu Glu Glu Ala Leu Arg Arg Tyr Tyr Ser Ser Pro Ile Ser Glu Leu
165 170 175GAA TTT TTA AAA GAA ATA GAA AAA AATGAG AGC TTT TTT TAATTCTTCT AT 635Glu Phe Leu Lys Glu Ile Glu Lys Asn Glu Ser Phe Phe
180 185 190GCGTGAAAAG CTAAGCCAAT TAAAAGCAAG GCAGCAAAAA C 676
(2) Sequence 706 data:
(i) sequence characteristics:
(A) length: 191 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 706: met Asp Glu Val Leu Lys Glu Ile Leu Ser Ser Tyr Gln Lys Arg Ala 151015 Leu Lys Leu Thr Lys Arg Val Arg Lys Lys Ile Phe Lys Asn Asp Pro
20 25 30Thr Glu Asn Gln Lys Lys Ala Ile Lys Ile Ala Leu Asn Thr Pro Asp
35 40 45Ile Ala Ile Ile Gln Gly Pro Pro Gly Thr Gly Lys Thr Thr Val Ile
50 55 60Asn Ala Ile Cys Glu Arg Leu Phe Glu Glu Tyr Pro Lys Asp Lys Asn65 70 75 80Ile Lys Gly Gln Ile Leu Leu Cys Ala Gln Gly His Asp Ala Thr Asn
85 90 95Asn Ala Arg Glu Arg Ile Lys Val Gly Gly Leu Pro Thr Phe Lys Phe
100 105 110Gly Ala Lys Lys Asn Ala Lys Glu Glu Gln Tyr Lys Gln Asp Glu Arg
115 120 125Leu Asn Glu Arg Leu Arg Glu Phe Ala Glu Thr Leu Ile Glu Ser Val
130 135 140Arg Lys Lys Leu Gln Lys Leu Gly Asp Tyr Glu Asn Ile Glu Lys Ile145 150 155 160Leu Asp Leu Glu Glu Ala Leu Arg Arg Tyr Tyr Ser Ser Pro Ile Ser
165 170 175Glu Leu Glu Phe Leu Lys Glu Ile Glu Lys Asn Glu Ser Phe Phe
180 185 190
(2) Sequence 707 data:
(i) sequence characteristics:
(A) length: 913 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 86...862
(D) Other information:
(xi) Description of the sequence: sequence 707: ATTTCATATT TTCTTTTAGG GGCATTCITT AGAGAATGCA ATTATTTTCT AATCTCTAAG 60AAATCAATAT CTAGGAATTA GGACC ATG CAA GAA AGA GTT TTT AAA AGA AAA 112
Met Gln Glu Arg Val Phe Lys Arg Lys
1 5GTT TTA GAT GCG AAT ATC TTA AAA GAA ATG CAT GCG AAC AAT GTC TGT 160Val Leu Asp Ala Asn Ile Leu Lys Glu Met His Ala Asn Asn Val Cys10 15 20 25TAT TCC AAG CAT TCA AAA GAT AGG TTT ATT CCT TTC AAA TTT GAT AAA 208Tyr Ser Lys His Ser Lys Asp Arg Phe Ile Pro Phe Lys Phe Asp Lys
30 3540TTT GGT TAT GTT GGA TGT AAA CTT TTT AAA AAG ATA TTA AAC TTT CCT 256Phe Gly Tyr Val Gly Cys Lys Leu Phe Lys Lys Ile Leu Asn Phe Pro
45 50 55AGC AAT ACA ACT TTC TTT GGT GGC ACA GGT TGT AAG AAA CTC ATG GAA 304Ser Asn Thr Thr Phe Phe Gly Gly Thr Gly Cys Lys Lys Leu Met Glu
60 65 70CTT TTA AGT GAA ATC GTT ATA GAT TCT AGA AGT TCT AAA ATT GCG TTA 352Leu Leu Ser Glu Ile Val Ile Asp Ser Arg Ser Ser Lys Ile Ala Leu
75 80 85AAC CGC CAT TAT GCC TTA ACT CGC TTG CAA TGG TGC GAT AGA ACC TTA 400Asn Arg His Tyr Ala Leu Thr Arg Leu Gln Trp Cys Asp Arg Thr Leu90 95 100 105AGA CAT AAT CTC CAA ATT TTA GAG AGA ATA GGA TTT CTA ACT GCT TTT 448Arg His Asn Leu Gln Ile Leu Glu Arg Ile Gly Phe Leu Thr Ala Phe
110 115 120AAG AAC AAA AAA GGT TAT ATT TTT TTG TCT ATG CAT GAC TTC ACT AAA 496Lys Asn Lys Lys Gly Tyr Ile Phe Leu Ser Met His Asp Phe Thr Lys
125 130 135ATA GAA AAC TAC GAA CAT TCA GGT TTG AAT GGG GAG AGC AAT TTA CCT 544Ile Glu Asn Tyr Glu His Ser Gly Leu Asn Gly Glu Ser Asn Leu Pro
140 145 150AAT AGC TTC TTT TTA GGA ATT TGT GGG TAT TTG AAA AAA CTC TTC AAG 592Asn Ser Phe Phe Leu Gly Ile Cys Gly Tyr Leu Lys Lys Leu Phe Lys
155 160 165AAA TTA AAA GAT AGA GCA TTC AGG CTC GCA AAC AAG CAC GGT GTA TTC 640Lys Leu Lys Asp Arg Ala Phe Arg Leu Ala Asn Lys His Gly Val Phe170 175 180 185TTT TTG AAA ATT CCT AAG CAT TTT CAA ATG CAA AAC TTT AAC AAT ATT688Phe Leu Lys Ile Pro Lys His Phe Gln Met Gln Asn Phe Asn Asn Ile
190 195 200TTT TTG GAG TTT GTG TCG GTT AAT AAT CCT TGT TTT TCT TAT AGA TTG 736Phe Leu Glu Phe Val Ser Val Asn Asn Pro Cys Phe Ser Tyr Arg Leu
205 210 215ACT TAT GAT CAA CTT GTT GGT AAA AAA ATT CCA AAT ATC AAG TGC TCT 784Thr Tyr Asp Gln Leu Val Gly Lys Lys Ile Pro Asn Ile Lys Cys Ser
220 225 230TAC CAA CAA GCA ATT GTA AAA AAG AAT ATC CAT AGA GCA TTA GAT GAA 832Tyr Gln Gln Ala Ile Val Lys Lys Asn Ile His Arg Ala Leu Asp Glu
235 240 245CTA TCT ATA GAT AAG GAA ATT TTA GCA TCA TAAAGAAGAC AAAGGATAAA AAT 885Leu Ser Ile Asp Lys Glu Ile Leu Ala Ser250 255GCAATTCCCA CTCAAAAAAG ATTTAAGA 913
(2) Sequence 708 data:
(i) sequence characteristics:
(A) length: 259 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 708: met Gln Glu Arg Val Phe Lys Arg Lys Val Leu Asp Ala Asn Ile Leu 151015 Lys Glu Met His Ala Asn Asn Val Cys Tyr Ser Lys His Ser Lys Asp
20 25 30Arg Phe Ile Pro Phe Lys Phe Asp Lys Phe Gly Tyr Val Gly Cys Lys
35 40 45Leu Phe Lys LysIle Leu Asn Phe Pro Ser Asn Thr Thr Phe Phe Gly
50 55 60Gly Thr Gly Cys Lys Lys Leu Met Glu Leu Leu Ser Glu Ile Val Ile65 70 75 80Asp Ser Arg Ser Ser Lys Ile Ala Leu Asn Arg His Tyr Ala Leu Thr
85 90 95Arg Leu Gln Trp Cys Asp Arg Thr Leu Arg His Asn Leu Gln Ile Leu
100 105 110Glu Arg Ile Gly Phe Leu Thr Ala Phe Lys Asn Lys Lys Gly Tyr Ile
115 120 125Phe Leu Ser Met His Asp Phe Thr Lys Ile Glu Asn Tyr G1u His Ser
130 135 140Gly Leu Asn Gly Glu Ser Asn Leu Pro Asn Ser Phe Phe Leu Gly Ile145 150 155 160Cys Gly Tyr Leu Lys Lys Leu Phe Lys Lys Leu Lys Asp Arg Ala Phe
165 170 175Arg Leu Ala Asn Lys His Gly Val Phe Phe Leu Lys Ile Pro Lys His
180 185 190Phe Gln Met Gln Asn Phe Asn Asn Ile Phe Leu Glu Phe Val Ser Val
195 200 205Asn Asn Pro Cys Phe Ser Tyr Arg Leu Thr Tyr Asp Gln Leu Val Gly
210 215 220Lys Lys Ile Pro Asn Ile Lys Cys Ser Tyr Gln Gln Ala Ile Val Lys225 230 235 240Lys Asn Ile His Arg Ala Leu Asp Glu Leu Ser Ile Asp Lys Glu Ile
245 250 255Leu Ala Ser
(2) Sequence 709 data:
(i) sequence characteristics:
(A) length: 3166 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...3113
(D) Other information:
(xi) Description of the sequence: sequence 709: ACTATTTGAA TAATGTCGAA TATGAAAAAC TTCTTAAAAA GTAGCATGCA ATG GAT 56
Met Asp
1CTA GAA GAA CTC TAT GCG CCT AAT CAC ATA GAG CGT TTG AAA GCG CGG 104Leu Glu Glu Leu Tyr Ala Pro Asn His Ile Glu Arg Leu Lys Ala Arg
5 10 15AGT TTT TTA AGA TCG ATT GCT TTT TTT GAT GAT TTT AGC GCT TCT TTT 152Ser Phe Leu Arg Ser Ile Ala Phe Phe Asp Asp Phe Ser Ala Ser Phe
20 25 30GAA TAC AGA GAT CTA TTT AGC GTT TTG GAA AAT ATC GTG CAA TTT GAT 200Glu Tyr Arg Asp Leu Phe Ser Val Leu Glu Asn Ile Val Gln Phe Asp35 40 45 50TAT GAA AAA AAG CCG TAT AAA GAT GAT TTG TAT TTT TTG TGC AAA TTT 248Tyr Glu Lys Lys Pro Tyr Lys Asp Asp Leu Tyr Phe Leu Cys Lys Phe
55 60 65GTG GAG CCA GCC CTA AAG GCT ATC TTT AGC AAT CTA AAT ACC AAT ATC 296Val Glu Pro Ala Leu Lys Ala Ile Phe Ser Asn Leu Asn Thr Asn Ile
70 75 80TAC CGA AAA CAT TTA AAA ATG CCT TTA GAA AAG GCT AGG GAA TTTGAC 344Tyr Arg Lys His Leu Lys Met Pro Leu Glu Lys Ala Arg Glu Phe Asp
85 90 95GCT AAA TGC GCG TTG GAT TTA GCC AAG CGA CCA GGT CGT AGT TTG AAA 392Ala Lys Cys Ala Leu Asp Leu Ala Lys Arg Pro Gly Arg Ser Leu Lys
100 105 110GAA AAG TTG TGC GAC AAT AAA GTA TTG AGC GTC AAG CGT TAT GTG AAT 440Glu Lys Leu Cys Asp Asn Lys Val Leu Ser Val Lys Arg Tyr Val Asn115 120 125 130GCC AAT ACG CAT GAA AAC AGG TTT CTC AAG CGT TTC ATT AAA GAA CTT 488Ala Asn Thr His Glu Asn Arg Phe Leu Lys Arg Phe Ile Lys Glu Leu
135 140 145TTA AGA ATA ATT CAT TGG CGC GAG ATA GAA TTC CAA CAG GTT TTT GAA 536Leu Arg Ile Ile His Trp Arg Glu Ile Glu Phe Gln Gln Val Phe Glu
150 155 160GAG TTA ATT TTC AGC ATA ACA AGT TTT TTA AAG AAT GGA GTA GCC CAA 584Glu Leu Ile Phe Ser Ile Thr Ser Phe Leu Lys Asn Gly Val Ala Gln
165 170 175CAA ATT GAT GAA AAA CAA GCC ATC ATT CCT AAT AAC TTG TTG CAT TTT 632Gln Ile Asp Glu Lys Gln Ala Ile Ile Pro Asn Asn Leu Leu His Phe
180 185 190GAT AAG CAC TAC AAA CGC ATT TTT AAA GCC CAT GAT TGG CTT TAT GAT 680Asp Lys His Tyr Lys Arg Ile Phe Lys Ala His Asp Trp Leu Tyr Asp195 200 205 210GGT GTG GGG TCA TTG ATG AAT TTG GAT CAA ATT TTC TAT TTG GAG TGT 728Gly Val Gly Ser Leu Met Asn Leu Asp Gln Ile Phe Tyr Leu Glu Cys
215 220 225TTA TAC CAA GCC CAA TTT TAT ACT TCT AAA AAC ATT GAA CCC ACG CTA 776Leu Tyr Gln Ala Gln Phe Tyr Thr Ser Lys Asn Ile Glu Pro Thr Leu
230 235 240ATT AGA AAT GAA CAA GAT TTA TAC GCG CTA ATT AAA AAT AGT TTT CCA 824Ile Arg Asn Glu Gln Asp Leu Tyr Ala Leu Ile Lys Asn Ser Phe Pro
245 250 255ATA AAA GAT TTA TCG TTT GAA AAG ATG CGT TTA AAA GCG AAA GAG TTT 872Ile Lys Asp Leu Ser Phe Glu Lys Met Arg Leu Lys Ala Lys Glu Phe
260 265 270TTT GAA AAT GAA TTA AGA CAG CCT ATA AAT TTA GAT CAA GAA ATT CCG 920Phe Glu Asn Glu Leu Arg Gln Pro Ile Asn Leu Asp Gln Glu Ile Pro275 280 285 290CAA TTG GAA TTG TGT AAG GGA GTT TAT AAA GAA ATG TAT ATT GAT ATG 968Gln Leu Glu Leu Cys Lys Gly Val Tyr Lys Glu Met Tyr Ile Asp Met
295 300 305TTT AGC CCT GAA CCT TTC GCT TTG TTA GTG GGT AAT GGC AAT GAA GAA 1016Phe Ser Pro Glu Pro Phe Ala Leu Leu Val Gly Asn Gly Asn Glu Glu
310 315 320AAG ATT TTA AAG CTC CCC CTT TTA GTC AAA AAG CAG GAG AAT AAT ACT 1064Lys Ile Leu Lys Leu Pro Leu Leu Val Lys Lys Gln Glu Asn Asn Thr
325 330 335TAT ATC AAC GCT AAT GGC GCT AAG GGT AAG ATA GAT GAA AAA GGT TAT 1112Tyr Ile Asn Ala Asn Gly Ala Lys Gly Lys Ile Asp Glu Lys Gly Tyr
340 345 350TTG GCC AAC GCT CTC AAA AAC TAT GAT GAG ACT CTT GTG GAA GCT TTT 1160Leu Ala Asn Ala Leu Lys Asn Tyr Asp Glu Thr Leu Val Glu Ala Phe355 360 365 370ATG AGA GAT TTC AAG GAA CGC TAT AAG ATA GAA AAA CTA TAT TAT TTA 1208Met Arg Asp Phe Lys Glu Arg Tyr Lys Ile Glu Lys Leu Tyr Tyr Leu
375 380 385TTAGAT GAT AAT ATT AAA AAT TTT GAA TTT GCT AAG ATC AAG CAT AAA 1256Leu Asp Asp Asn Ile Lys Asn Phe Glu Phe Ala Lys Ile Lys His Lys
390 395 400ATA AGC TTG TAT TTT AAA GAC GCA AAA TTC TAT CCT AAA AGC GTT GCT 1304Ile Ser Leu Tyr Phe Lys Asp Ala Lys Phe Tyr Pro Lys Ser Val Ala
405 410 415TTA GGA TTT AGT TCT TTG TTT GAA AAT AAA TTA AAG AAA AAT GAG CGT 1352Leu Gly Phe Ser Ser Leu Phe Glu Asn Lys Leu Lys Lys Asn Glu Arg
420 425 430TTG CGT TAT AAC AGC GTG GAT TTG GTC GTT AAA GAA AAC CAT AAA AGT 1400Leu Arg Tyr Asn Ser Val Asp Leu Val Val Lys Glu Asn His Lys Ser435 440 445 450AAG ACC TTT AAT GAT TGT GGC TTG GTT TTG GAG AGG CAA AAA AGC GAT 1448Lys Thr Phe Asn Asp Cys Gly Leu Val Leu Glu Arg Gln Lys Ser Asp
455 460 465GAT TCA AAA GAG TTC CTT ATT CTA CAA GAT TCT TTT ATC AAA AAA GCT 1496Asp Ser Lys Glu Phe Leu Ile Leu Gln Asp Ser Phe Ile Lys Lys Ala
470 475 480TTA AAA AAT TTT AAA AGA GCC TTA GGA TTA GAA AAA GAA GGC TTT ATT 1544Leu Lys Asn Phe Lys Arg Ala Leu Gly Leu Glu Lys Glu Gly Phe Ile
485 490 495CTG TAT AAA GAA TGC TTG CCT AAG CTC TCT ATG GAA GTG GTT AAA GAC 1592Leu Tyr Lys Glu Cys Leu Pro Lys Leu Ser Met Glu Val Val Lys Asp
500 505 510GGG CGG TTT AAA AAT TTT GAG ATC ATT AAA GAT AAA ACC ATT TTA GGA 1640Gly Arg Phe Lys Asn Phe Glu Ile Ile Lys Asp Lys Thr Ile Leu Gly515 520 525 530GAT AAA GAA ACC CTA GAG ATT GAA ACG CCT TTT ATT ATC CCT AAA GGG 1688Asp Lys Glu Thr LeuGlu Ile Glu Thr Pro Phe Ile Ile Pro Lys Gly
535 540 545CGA GAA AGT TTT GCT TTG CCC TTG ATC CTA AAT GAA GAA AAA ATC GCC 1736Arg Glu Ser Phe Ala Leu Pro Leu Ile Leu Asn Glu Glu Lys Ile Ala
550 555 560TAT CAA GGT AAA ATC ACC TCT AAA GAT TTT CCC CTA GAA AAT GAC GAA 1784Tyr Gln Gly Lys Ile Thr Ser Lys Asp Phe Pro Leu Glu Asn Asp Glu
565 570 575GAA TAC AAA CTC ACG CTC ACT TAT GAC ATT GGC ACC GAG TTT AAC TAT 1832Glu Tyr Lys Leu Thr Leu Thr Tyr Asp Ile Gly Thr Glu Phe Asn Tyr
580 585 590GTG TTA GAG TTT AAA CCT GTC AAT AAT GAT TTA AAG CCC ATT GTC ATG 1880Val Leu Glu Phe Lys Pro Val Asn Asn Asp Leu Lys Pro Ile Val Met595 600 605 610GAA TGG CAG CGT ATT GAT AGG GTT GAA CTC CCT ACG CCC GAT TCC ATC 1928Glu Trp Gln Arg Ile Asp Arg Val Glu Leu Pro Thr Pro Asp Ser Ile
615 620 625AAA AAA CCA AGT ATT GAT GAA CTA AAA AAT GAC TTT AAT CCT AAA AGG 1976Lys Lys Pro Ser Ile Asp Glu Leu Lys Asn Asp Phe Asn Pro Lys Arg
630 635 640GGC AAA AGT TCT GAT TTG TTT GAG TGG GCG CTA GAG CAA TTA GAG ACA 2024Gly Lys Ser Ser Asp Leu Phe Glu Trp Ala Leu Glu Gln Leu Glu Thr
645 650 655TTG AAA GAT TTA AAT AGT CCA CCC AGA TTT GTT TTA GAG AAA AAA CTA 2072Leu Lys Asp Leu Asn Ser Pro Pro Arg Phe Val Leu Glu Lys Lys Leu
660 665 670GAA TGC GGT GGA ATC TCA ATA ATA GGG GAA GAT AGA AAC AAT GAA CTT 2120Glu Cys Gly Gly Ile Ser Ile Ile Gly Glu Asp Arg Asn Asn Glu Leu675680 685 690TTT TAC ATA ATG GAA ACA AAT GGT AAA AAA GTT TTT TGT CAT AGC CGT 2168Phe Tyr Ile Met Glu Thr Asn Gly Lys Lys Val Phe Cys His Ser Arg
695 700 705CAA TGC AAA GGG AGC GTG AAC AAA GAT GAG CTT TCA TTA GGC GCG CGA 2216Gln Cys Lys Gly Ser Val Asn Lys Asp Glu Leu Ser Leu Gly Ala Arg
710 715 720GTG TGT TTG GAA GTG GGG CCA GAT AAG AAC GAC CAT GGT AAA TAT CGA 2264Val Cys Leu Glu Val Gly Pro Asp Lys Asn Asp His Gly Lys Tyr Arg
725 730 735GGT AAA ATT TAT GGT TTG GAA AAA AAT AGA GAA ATT GTT TTA TTA AAT 2312Gly Lys Ile Tyr Gly Leu Glu Lys Asn Arg Glu Ile Val Leu Leu Asn
740 745 750ACA GCT AAA AAT TCT TAT CAA AGA AAA CCT CTA GAT GAG AAA ATT AAA 2360Thr Ala Lys Asn Ser Tyr Gln Arg Lys Pro Leu Asp Glu Lys Ile Lys755 760 765 770CAC AGA ATA GAA GCG CTC AAA AGA ATC AAG TAT CCT TGT TTA AAA ATT 2408His Arg Ile Glu Ala Leu Lys Arg Ile Lys Tyr Pro Cys Leu Lys Ile
775 780 785TTT TCA CAT TAC ATG CTT GAA GAG TTA GAA ACC TTA AAT CCT GAA TTT 2456Phe Ser His Tyr Met Leu Glu Glu Leu Glu Thr Leu Asn Pro Glu Phe
790 795 800GCT ACT CCC TTT AAA GAA TAT TTG AAG CGG TTA GAA GAA TAT TAT TTT 2504Ala Thr Pro Phe Lys Glu Tyr Leu Lys Arg Leu Glu Glu Tyr Tyr Phe
805 810 815GAC CCA CAA ACA GAC AGA GAT TTT AAA AAA GGA CTC TTG GAT TTC TTT 2552Asp Pro Gln Thr Asp Arg Asp Phe Lys Lys Gly Leu Leu Asp Phe Phe
820 825 830AGC CGCTTG AAT GAT AGT ATT CCC GCA AAA TTA CAA CAA GAA TTT ATT 2600Ser Arg Leu Asn Asp Ser Ile Pro Ala Lys Leu Gln Gln Glu Phe Ile835 840 845 850AAT TTA CCT TCT ACG GAT TTT TTA ACC AGA TGT TTA GGC TCT CTT GAA 2648Asn Leu Pro Ser Thr Asp Phe Leu Ser Arg Cys Leu Gly Ser Leu Glu
855 860 865AAA GAC TTT CAA AAA ACG ATT TTT AAG AAG CTT AAA GTT ACT AAC CTA 2696Lys Asp Phe Gln Lys Thr Ile Phe Lys Lys Leu Lys Val Thr Asn Leu
870 875 880AAG ACT TTA AGT ATT GTG GCT AGG GCT AGT TGG AAT AAT GAG AAA TTT 2744Lys Thr Leu Ser Ile Val Ala Arg Ala Ser Trp Asn Asn Glu Lys Phe
885 890 895TTA GAG AAC TTG ATG GCT CAA ACC AGC TTG GAG CAG CAA AAA GAC TTT 2792Leu Glu Asn Leu Met Ala Gln Thr Ser Leu Glu Gln Gln Lys Asp Phe
900 905 910TTG AAG CGT ATA GAA GAG TGT TTG AAA AAT CCT GAG TCA TTT TAT TTC 2840Leu Lys Arg Ile Glu Glu Cys Leu Lys Asn Pro Glu Ser Phe Tyr Phe915 920 925 930AGT AGC GCA TGC GAA TTG CTG TTA GCG TTT TTG TCT TAT CGC AAC GCT 2888Ser Ser Ala Cys Glu Leu Leu Leu Ala Phe Leu Ser Tyr Arg Asn Ala
935 940 945AAA AGA GAG TTG GAA TTG ATC CCT GAA AGC GAA AAA ACC ATG CGT TTA 2936Lys Arg Glu Leu Glu Leu Ile Pro Glu Ser Glu Lys Thr Met Arg Leu
950 955 960TTG GAC AGC ATA GAT AAA GCG ATA GAA AAA GAG ACT GAA ATT AAA AGC 2984Leu Asp Ser Ile Asp Lys Ala Ile Glu Lys Glu Thr Glu Ile Lys Ser
965 970 975TTT GTA AAA TTA GAG CTA AAA AAT CAA AGC TTC AAC AAT ATC CCA CCT 3032Phe Val LysLeu Glu Leu Lys Asn Gln Ser Phe Asn Asn Ile Pro Pro
980 985 990TTG TTG TCG GCG TTA CGC TTG TAT TTA AGG GGG GAT TTG GAA GGT GTT 3080Leu Leu Ser Ala Leu Arg Leu Tyr Leu Arg Gly Asp Leu Glu Gly Val995 1000 1005 1010GGA ATT GAA ATT AAT GGG ACA GAA GAG GAT GAA TAAATCAAAC AAATTAGTCA 3133Gly Ile Glu Ile Asn Gly Thr Glu Glu Asp Glu
1015 1020TTATCAATCG CGCCATTCCA GGTGGGGGCA AGA 3166
(2) Sequence 710 data:
(i) sequence characteristics:
(A) length: 1021 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 710: met Asp Leu Glu Glu Leu Tyr Ala Pro Asn His Ile Glu Arg Leu Lys 151015 Ala Arg Ser Phe Leu Arg Ser Ile Ala Phe Phe Asp Asp Phe Ser Ala
20 25 30Ser Phe Glu Tyr Arg Asp Leu Phe Ser Val Leu Glu Asn Ile Val Gln
35 40 45Phe Asp Tyr Glu Lys Lys Pro Tyr Lys Asp Asp Leu Tyr Phe Leu Cys
50 55 60Lys Phe Val Glu Pro Ala Leu Lys Ala Ile Phe Ser Asn Leu Asn Thr65 70 75 80Asn Ile Tyr Arg Lys His Leu Lys Met Pro Leu Glu Lys Ala Arg Glu
85 90 95Phe Asp Ala Lys Cys Ala Leu Asp Leu Ala Lys Arg Pro Gly ArgSer
100 105 110Leu Lys Glu Lys Leu Cys Asp Asn Lys Val Leu Ser Val Lys Arg Tyr
115 120 125Val Asn Ala Asn Thr His Glu Asn Arg Phe Leu Lys Arg Phe Ile Lys
130 135 140Glu Leu Leu Arg Ile Ile His Trp Arg Glu Ile Glu Phe Gln Gln Val145 150 155 160Phe Glu Glu Leu Ile Phe Ser Ile Thr Ser Phe Leu Lys Asn Gly Val
165 170 175Ala Gln Gln Ile Asp Glu Lys Gln Ala Ile Ile Pro Asn Asn Leu Leu
180 185 190His Phe Asp Lys His Tyr Lys Arg Ile Phe Lys Ala His Asp Trp Leu
195 200 205Tyr Asp Gly Val Gly Ser Leu Met Asn Leu Asp Gln Ile Phe Tyr Leu
210 215 220Glu Cys Leu Tyr Gln Ala Gln Phe Tyr Thr Ser Lys Asn Ile Glu Pro225 230 235 240Thr Leu Ile Arg Asn Glu Gln Asp Leu Tyr Ala Leu Ile Lys Asn Ser
245 250 255Phe Pro Ile Lys Asp Leu Ser Phe Glu Lys Met Arg Leu Lys Ala Lys
260 265 270Glu Phe Phe Glu Asn Glu Leu Arg Gln Pro Ile Asn Leu Asp Gln Glu
275 280 285Ile Pro Gln Leu Glu Leu Cys Lys Gly Val Tyr Lys Glu Met Tyr Ile
290 295 300Asp Met Phe Ser Pro Glu Pro Phe Ala Leu Leu Val Gly Asn Gly Asn305 310 315 320Glu Glu Lys Ile Leu Lys Leu Pro Leu Leu Val Lys Lys Gln GluAsn
325 330 335Asn Thr Tyr Ile Asn Ala Asn Gly Ala Lys Gly Lys Ile Asp Glu Lys
340 345 350Gly Tyr Leu Ala Asn Ala Leu Lys Asn Tyr Asp Glu Thr Leu Val Glu
355 360 365Ala Phe Met Arg Asp Phe Lys Glu Arg Tyr Lys Ile Glu Lys Leu Tyr
370 375 380Tyr Leu Leu Asp Asp Asn Ile Lys Asn Phe Glu Phe Ala Lys Ile Lys385 390 395 400His Lys Ile Ser Leu Tyr Phe Lys Asp Ala Lys Phe Tyr Pro Lys Ser
405 410 415Val Ala Leu Gly Phe Ser Ser Leu Phe Glu Asn Lys Leu Lys Lys Asn
420 425 430Glu Arg Leu Arg Tyr Asn Ser Val Asp Leu Val Val Lys Glu Asn His
435 440 445Lys Ser Lys Thr Phe Asn Asp Cys Gly Leu Val Leu Glu Arg Gln Lys
450 455 460Ser Asp Asp Ser Lys Glu Phe Leu Ile Leu Gln Asp Ser Phe Ile Lys465 470 475 480Lys Ala Leu Lys Asn Phe Lys Arg Ala Leu Gly Leu Glu Lys Glu Gly
485 490 495Phe Ile Leu Tyr Lys Glu Cys Leu Pro Lys Leu Ser Met Glu Val Val
500 505 510Lys Asp Gly Arg Phe Lys Asn Phe Glu Ile Ile Lys Asp Lys Thr Ile
515 520 525Leu Gly Asp Lys Glu Thr Leu Glu Ile Glu Thr Pro Phe Ile Ile Pro
530 535 540Lys Gly Arg Glu Ser Phe Ala Leu Pro Leu Ile Leu Asn Glu Glu Lys545 550 555 560Ile Ala Tyr Gln Gly Lys Ile Thr Ser Lys Asp Phe Pro Leu Glu Asn
565 570 575Asp Glu Glu Tyr Lys Leu Thr Leu Thr Tyr Asp Ile Gly Thr Glu Phe
580 585 590Asn Tyr Val Leu Glu Phe Lys Pro Val Asn Asn Asp Leu Lys Pro Ile
595 600 605Val Met Glu Trp Gln Arg Ile Asp Arg Val Glu Leu Pro Thr Pro Asp
610 615 620Ser Ile Lys Lys Pro Ser Ile Asp Glu Leu Lys Asn Asp Phe Asn Pro625 630 635 640Lys Arg Gly Lys Ser Ser Asp Leu Phe Glu Trp Ala Leu Glu Gln Leu
645 650 655Glu Thr Leu Lys Asp Leu Asn Ser Pro Pro Arg Phe Val Leu Glu Lys
660 665 670Lys Leu Glu Cys Gly Gly Ile Ser Ile Ile Gly Glu Asp Arg Asn Asn
675 680 685Glu Leu Phe Tyr Ile Met Glu Thr Asn Gly Lys Lys Val Phe Cys His
690 695 700Ser Arg Gln Cys Lys Gly Ser Val Asn Lys Asp Glu Leu Ser Leu Gly705 710 715 720Ala Arg Val Cys Leu Glu Val Gly Pro Asp Lys Asn Asp His Gly Lys
725 730 735Tyr Arg Gly Lys Ile Tyr Gly Leu Glu Lys Asn Arg Glu Ile Val Leu
740 745 750Leu Asn Thr Ala Lys Asn Ser Tyr Gln Arg Lys Pro Leu Asp Glu Lys
755 760 765Ile Lys His Arg Ile Glu Ala Leu Lys Arg IleLys Tyr Pro Cys Leu
770 775 780Lys Ile Phe Ser His Tyr Met Leu Glu Glu Leu Glu Thr Leu Asn Pro785 790 795 800Glu Phe Ala Thr Pro Phe Lys Glu Tyr Leu Lys Arg Leu Glu Glu Tyr
805 810 815Tyr Phe Asp Pro Gln Thr Asp Arg Asp Phe Lys Lys Gly Leu Leu Asp
820 825 830Phe Phe Ser Arg Leu Asn Asp Ser Ile Pro Ala Lys Leu Gln Gln Glu
835 840 845Phe Ile Asn Leu Pro Ser Thr Asp Phe Leu Ser Arg Cys Leu Gly Ser
850 855 860Leu Glu Lys Asp Phe Gln Lys Thr Ile Phe Lys Lys Leu Lys Val Thr865 870 875 880Asn Leu Lys Thr Leu Ser Ile Val Ala Arg Ala Ser Trp Asn Asn Glu
885 890 895Lys Phe Leu Glu Asn Leu Met Ala Gln Thr Ser Leu Glu Gln Gln Lys
900 905 910Asp Phe Leu Lys Arg Ile Glu Glu Cys Leu Lys Asn Pro Glu Ser Phe
915 920 925Tyr Phe Ser Ser Ala Cys Glu Leu Leu Leu Ala Phe Leu Ser Tyr Arg
930 935 940Asn Ala Lys Arg Glu Leu Glu Leu Ile Pro Glu Ser Glu Lys Thr Met945 950 955 960Arg Leu Leu Asp Ser Ile Asp Lys Ala Ile Glu Lys Glu Thr Glu Ile
965 970 975Lys Ser Phe Val Lys Leu Glu Leu Lys Asn Gln Ser Phe Asn Asn Ile
980 985 990Pro Pro Leu Leu Ser Ala Leu Arg LeuTyr Leu Arg Gly Asp Leu Glu
995 1000 1005Gly Val Gly Ile Glu Ile Asn Gly Thr Glu Glu Asp Glu 1010 1015 1020
(2) Sequence 711 data:
(i) sequence characteristics:
(A) length: 281 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...180
(D) Other information:
(xi) Description of the sequence: sequence 711: AAC AAA ACT TTT TTA AGG GGT AAA AAC CCT TTA GTT ACA AGA AAG AGA 48Asn Lys Thr Phe Leu Arg Gly Lys Asn Pro Leu Val Thr Arg Lys Arg 151015 AGT TTT GTC ATC AAA ATG AAG TTT TTT AAA GAA AAA GAA AAA GAA GTT 96Ser Phe Val Ile Lys Met Lys Phe Phe Lys Glu Lys Glu Lys Glu Val
20 25 30TCA AAA ATT AAA AGT TTG AGA AAG TTT GAG TCA AAT CCG CTA GTA AGA 144Ser Lys Ile Lys Ser Leu Arg Lys Phe Glu Ser Asn Pro Leu Val Arg
35 40 45TTT GAC CCT AGC GCT CTT GCG CTA GAG CCA AAA TTT TAGTATAATG GCGTTG 196Phe Asp Pro Ser Ala Leu Ala Leu Glu Pro Lys Phe
50 55 60CGGATACCAT TAAAACTATG ATTACTAATC TCATGTTAGG TTATCTCCTT TTCTGAGGTA 256ACCACCCACT ATTACCCCCA ACCCT 281
(2) Sequence 712 data:
(i) sequence characteristics:
(A) length: 60 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 712: asn Lys Thr Phe Leu Arg Gly Lys Asn Pro Leu Val Thr Arg Lys Arg 151015 Ser Phe Val Ile Lys Met Lys Phe Phe Lys Glu Lys Glu Lys Glu Val
20 25 30Ser Lys Ile Lys Ser Leu Arg Lys Phe Glu Ser Asn Pro Leu Val Arg
35 40 45Phe Asp Pro Ser Ala Leu Ala Leu Glu Pro Lys Phe
50 55 60
(2) Sequence 713 data:
(i) sequence characteristics:
(A) length: 745 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 692 l. 5l
(D) Other information:
(xi) Description of the sequence: sequence 713: GCGCGAATTC TTCTTGGACA TTGATTTTAT AGCGCGATTT AGAAATGGCC ATG CCC 56
Met Pro
1ACA ATG AAC GCT CCT AAA GAC ATA GAA AAC CCA AAA AAA TGG CTC AAC 104Thr Met Asn Ala Pro Lys Asp Ile Glu Asn Pro Lys Lys Trp Leu Asn
5 10 15CCT GCT GCG CTG CAA ACA ATC ACT AAA ATC GTG CCT ATA AAA ATT TCA 152Pro Ala Ala Leu Gln Thr Ile Thr Lys Ile Val Pro Ile Lys Ile Ser
20 25 30GGC AGG CGC GTG TCT TTT GCT TGC TCT AAG ATG AGA TTA GCC CCT TTT 200Gly Arg Arg Val Ser Phe Ala Cys Ser Lys Met Arg Leu Ala Pro Phe35 40 45 50TTT CCA GGC AAT AAT AAA AGA ACT AAA ATA ATC CCT GCT GAA ATA AAG 248Phe Pro Gly Asn Asn Lys Arg Thr Lys Ile Ile Pro Ala Glu Ile Lys
55 60 65GTT TTA AGA ATG AGT AAA TTA ACA TTA GAA TCT TTA CTA CCT AGA ATA 296Val Leu Arg Met Ser Lys Leu Thr Leu Glu Ser Leu Leu Pro Arg Ile
70 75 80GTG AGG ATT AAA AGC ATG GGA ATG GCT GCA ATA TCT TGG AAA ATC AAA 344Val Arg Ile Lys Ser Met Gly Met Ala Ala Ile Ser Trp Lys Ile Lys
85 90 95ATC CCC ACC GCG CTC TTT CCC ATG GGC GTG CTA AGC TGT TTG GAA TCT 392Ile Pro Thr Ala Leu Phe Pro Met Gly Val Leu Ser Cys Leu Glu Ser
100 105 110TCA AAG AAT TTC AGC ACA ATA GCG GTT GAA GAG AGC GAA AGC CCC ATG 440Ser Lys Asn Phe Ser Thr Ile Ala Val Glu Glu Ser Glu Ser Pro Met115 120 125 130CCT AAA ACA AGG GAA AAA ATG GGT GAA AGA CCC AAA ACA AAA TAC CCC 488Pro Lys Thr Arg Glu Lys Met Gly Glu Arg Pro Lys Thr Lys Tyr Pro
135 140 145AAT AAA AAA GCG ATT AAA GCG CAT AAA ACC ACT TGT AAA AGC CCA AAA 536Asn Lys Lys Ala Ile Lys Ala His Lys Thr Thr Cys Lys Ser Pro Lys
150 155 160ACC AGC ACT TCT TGT TTG ATG GAT TTG AGC TTG TCA AAA TTA AAC TCA 584Thr Ser Thr Ser Cys Leu Met Asp Leu Ser Leu Ser Lys Leu Asn Ser
165 170 175ATG CCT ATC ATA AAC ATT AAA AAG ACG ATA CCA AAT TCG CCA ATA TCA 632Met Pro Ile Ile Asn Ile Lys Lys Thr Ile Pro Asn Ser Pro Ile Ser
180 185 190GAC AAC AAA TCA AAA TCA TTA ATT TTA AAA AAA GCC GCT AAG ACC GTT 680Asp Asn Lys Ser Lys Ser Leu Ile Leu Lys Lys Ala Ala Lys Thr Val195 200 205 210CCT GTG CAA ATG TAACCAATGA TAACAGGCAT GTCTAATTTC TTTAAAAAGA TTCCA 737Pro Val Gln MetAAGCCCAC 745
(2) Sequence 714 data:
(i) sequence characteristics:
(A) length: 214 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 714: met Pro Thr Met Asn Ala Pro Lys Asp Ile Glu Asn Pro Lys Lys Trp 151015 Leu Asn Pro Ala Ala Leu Gln Thr Ile Thr Lys Ile Val Pro Ile Lys
20 25 30Ile Ser Gly Arg Arg Val Ser Phe Ala Cys Ser Lys Met Arg Leu Ala
35 40 45Pro Phe Phe Pro Gly Asn Asn Lys Arg Thr Lys Ile Ile Pro Ala Glu
50 55 60Ile Lys Val Leu Arg Met Ser Lys Leu Thr Leu Glu Ser Leu Leu Pro65 70 75 80Arg Ile Val Arg Ile Lys Ser Met Gly Met Ala Ala Ile Ser Trp Lys
85 90 95Ile Lys Ile Pro Thr Ala Leu Phe Pro Met Gly Val Leu Ser Cys Leu
100 105 110Glu Ser Ser Lys Asn Phe Ser Thr Ile Ala Val Glu Glu Ser Glu Ser
115 120 125Pro Met Pro Lys Thr Arg Glu Lys Met Gly Glu Arg Pro Lys Thr Lys
130 135 140Tyr Pro Asn Lys Lys Ala Ile Lys Ala His Lys Thr Thr Cys Lys Ser145 150 155 160Pro Lys Thr Ser Thr Ser Cys Leu Met Asp Leu Ser Leu Ser Lys Leu
165 170 175Asn Ser Met Pro Ile Ile Asn Ile Lys Lys Thr Ile Pro Asn Ser Pro
180 185 190Ile Ser Asp Asn Lys Ser Lys Ser Leu Ile Leu Lys Lys Ala Ala Lys
195 200 205Thr Val Pro Val Gln Met
210
(2) Sequence 715 data:
(i) sequence characteristics:
(A) length: 601 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...491
(D) Other information:
(xi) Description of the sequence: sequence 715: GCCTTTGCTC ACCCTAAAGA TAAAAATAAA ATTCACGAAG GTTACGCTTA ATG CGT 56
Met Arg
1TTA GAA AAT CTA AGC CAG CAA AAA ATT CTT CAA CTC TCT GGC GGG CAA 104Leu Glu Asn Leu Ser Gln Gln Lys Ile Leu Gln Leu Ser Gly Gly Gln
5 10 15GCC CAA CGA GTC GCT TTA GCA AGA GCT TTA ATC GCA GCC AAG AAT CTA 152Ala Gln Arg Val Ala Leu Ala Arg Ala Leu Ile Ala Ala Lys Asn Leu
20 25 30TTG CTT TTA GAT GAG CCT TTA AAC GCC TTA GAT AAC GCC TTA AAA AAC 200Leu Leu Leu Asp Glu Pro Leu Asn Ala Leu Asp Asn Ala Leu Lys Asn35 40 45 50GAA GTG CAA CAA GGT TTG CTT GAT TTT ATC AAG CGT GAA AAT TTA AGC 248Glu Val Gln Gln Gly Leu Leu Asp Phe Ile Lys Arg Glu Asn Leu Ser
55 60 65GTG TTA TTG GTA AGC CAT AAC CCC AAT GAA ATC ACC AAG CTC GCG CAA 296Val Leu Leu Val Ser His Asn Pro Asn Glu Ile Thr Lys Leu Ala Gln
70 75 80ACT TTC CTC TTT TTA AAC AAT GGC GTT ATT GAT CCT AAT CAA GAA AAT 344Thr Phe Leu Phe Leu Asn Asn Gly Val Ile Asp Pro Asn Gln Glu Asn
85 90 95CGG CTT TTT TCA AAC CGC TTA TTA ATA AAA CCT CTC TTT GAA GAT GAA 392Arg Leu Phe Ser Asn Arg Leu Leu Ile Lys Pro Leu Phe Glu Asp Glu
100 105 110AAT TAT TGC CAT TAT GAG GTC ATT TCT CAA ACG ATT AGT TTG CCC AAA 440Asn Tyr Cys His Tyr Glu Val Ile Ser Gln Thr Ile Ser Leu Pro Lys115 120 125 130GAT TGT CTG AAC CCA ACT TTT AAG CTT GAT TTC AAT CAA AAC AAA AAA 488Asp Cys Leu Asn Pro Thr Phe Lys Leu Asp Phe Asn Gln Asn Lys Lys
135 140 145TTT TAGAAATATT TTTTCATTTT CCTCTTAAAA CCCTCTTATT TTTCAAAAGG AGTTGC 547PheTTAACAACCG CTAAAATCAA ACTCTTTTAT TTTAATACCC AATGAAAACA GAGC 601
(2) Sequence 716 data:
(i) sequence characteristics:
(A) length: 147 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 716: met Arg Leu Glu Asn Leu Ser Gln Gln Lys Ile Leu Gln Leu Ser Gly 151015 Gly Gln Ala Gln Arg Val Ala Leu Ala Arg Ala Leu Ile Ala Ala Lys
20 25 30Asn Leu Leu Leu Leu Asp Glu Pro Leu Asn Ala Leu Asp Asn Ala Leu
35 40 45Lys Asn Glu Val Gln Gln Gly Leu Leu Asp Phe Ile Lys Arg Glu Asn
50 55 60Leu Ser Val Leu Leu Val Ser His Asn Pro Asn Glu Ile Thr Lys Leu65 70 75 80Ala Gln Thr Phe Leu Phe Leu Asn Asn Gly Val Ile Asp Pro Asn Gln
85 90 95Glu Asn Arg Leu Phe Ser Asn Arg Leu Leu Ile Lys Pro Leu Phe Glu
100 105 110Asp Glu Asn Tyr Cys His Tyr Glu Val Ile Ser Gln Thr Ile Ser Leu
115 120 125Pro Lys Asp Cys Leu Asn Pro Thr Phe Lys Leu Asp Phe Asn Gln Asn
130 135 140Lys Lys Phe145
(2) Sequence 717 data:
(i) sequence characteristics:
(A) length: 1530 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...1440
(D) Other information:
(xi) Description of the sequence: sequence 717: TTAAGCCATT TTTGAATACA ATAAGAGTAT TTTATTTTTA AGGTTAGAAC A ATG AGT 57
Met Ser
1TTG ATC GTT ACG CGC TTC GCT CCA TCG CCC ACT GGC TAC CTC CAC ATA 105Leu Ile Val Thr Arg Phe Ala Pro Ser Pro Thr Gly Tyr Leu His Ile
5 10 15GGA GGC TTA AGA ACA GCC ATT TTC AAT TAT CTT TTT GCA CGA GCC AAT 153Gly Gly Leu Arg Thr Ala Ile Phe Asn Tyr Leu Phe Ala Arg Ala Asn
20 25 30CAA GGA AAA TTT TTT TTA CGC ATT GAA GAC ACG GAT TTG AGC CGT AAC 201Gln Gly Lys Phe Phe Leu Arg Ile Glu Asp Thr Asp Leu Ser Arg Asn35 4045 50TCT ATA GAA GCG GCT AAC GCC ATT ATA GAA GCT TTC AAA TGG GTA GGG 249Ser Ile Glu Ala Ala Asn Ala Ile Ile Glu Ala Phe Lys Trp Val Gly
55 60 65CTA GAA TAC GAT GGC GAA ATC CTC TAC CAA TCC AAA CGC TTT GAG ATT 297Leu Glu Tyr Asp Gly Glu Ile Leu Tyr Gln Ser Lys Arg Phe Glu Ile
70 75 80TAT AAA GAA TAC ATT CAA AAA CTC TTA GAT GAA GAC AAA GCC TAT TAT 345Tyr Lys Glu Tyr Ile Gln Lys Leu Leu Asp Glu Asp Lys Ala Tyr Tyr
85 90 95TGT TAC ATG AGC AAA GAA GAG TTG GAC GCT TTG AGA GAA GAG CAA AAA 393Cys Tyr Met Ser Lys Glu Glu Leu Asp Ala Leu Arg Glu Glu Gln Lys
100 105 110GCC AGG AAA GAA ACC CCA CGC TAT GAC AAT CGC TAT CGT GAT TTT AAA 441Ala Arg Lys Glu Thr Pro Arg Tyr Asp Asn Arg Tyr Arg Asp Phe Lys115 120 125 130GGC ACG CCT CCT AAA GGC ATA GAG CCT GTG GTA AGG ATT AAA GTC CCC 489Gly Thr Pro Pro Lys Gly Ile Glu Pro Val Val Arg Ile Lys Val Pro
135 140 145CAA AAT GAG GTG ATT GGT TTT AAT GAC GGG GTT AAA GGC GAA GTG AAA 537Gln Asn Glu Val Ile Gly Phe Asn Asp Gly Val Lys Gly Glu Val Lys
150 155 160GTG AAT ACT AAC GAA TTA GAC GAT TTT ATT ATC GCC AGG AGC GAT GGG 585Val Asn Thr Asn Glu Leu Asp Asp Phe Ile Ile Ala Arg Ser Asp Gly
165 170 175ACA CCC ACT TAT AAC TTT GTG GTT ACT ATT GAT GAC GCT TTA ATG GGG 633Thr Pro Thr Tyr Asn Phe Val Val Thr Ile Asp Asp Ala Leu Met Gly
180 185 190ATT ACT GAT GTG ATT AGA GGC GAT GAT CAC CTT TCT AAC ACC CCT AAA 681Ile Thr Asp Val Ile Arg Gly Asp Asp His Leu Ser Asn Thr Pro Lys195 200 205 210CAA ATC GTT CTT TAT AAG GCT TTG AAT TTT AAA ATC CCT AAT TTT TTC 729Gln Ile Val Leu Tyr Lys Ala Leu Asn Phe Lys Ile Pro Asn Phe Phe
215 220 225CAT GTG CCG ATG ATT TTG AAT GAA GAA GGG CAA AAA TTA AGC AAA CGC 777His Val Pro Met Ile Leu Asn Glu Glu Gly Gln Lys Leu Ser Lys Arg
230 235 240CAT GGG GCC ACT AAT GTG ATG GAC TAT CAA GAA ATG GGC TAT CTT AAG 825His Gly Ala Thr Asn Val Met Asp Tyr Gln Glu Met Gly Tyr Leu Lys
245 250 255GAA GCT TTA GTG AAT TTT TTA GCG CGT TTG GGG TGG AGC TAT CAG GAT 873Glu Ala Leu Val Asn Phe Leu Ala Arg Leu Gly Trp Ser Tyr Gln Asp
260 265 270AAA GAG GTT TTT AGC ATG CAA GAA TTG CTA GAA TTA TTT GAT CCT AAA 921Lys Glu Val Phe Ser Met Gln Glu Leu Leu Glu Leu Phe Asp Pro Lys275 280 285 290GAT TTG AAT TCT TCG CCC AGT TGC TTC AGC TGG CAC AAG CTT AAT TGG 969Asp Leu Asn Ser Ser Pro Ser Cys Phe Ser Trp His Lys Leu Asn Trp
295 300 305CTC AAC GCT CAT TAT TTA AAA AAC CAA AGT GTG CAA GAA TTG TTA AAA 1017Leu Asn Ala His Tyr Leu Lys Asn Gln Ser Val Gln Glu Leu Leu Lys
310 315 320CTT TTA AAG CCT TTT AGT TTT AGC GAT CTC TCG CAT TTA AAC CCC ACT 1065Leu Leu Lys Pro Phe Ser Phe Ser Asp Leu Ser His Leu Asn Pro Thr
325 330 335CAA TTG GAT CGC TTG TTA GAC GCT CTC AAA GAA AGA TCT CAA ACA CTA 1113Gln Leu Asp Arg Leu Leu Asp Ala Leu Lys Glu Arg Ser Gln Thr Leu
340 345 350AAA GAA TTA GCC CTT AAA ATA GAT GAG GTT TTA ATC GCC CCT GTG GAG 1161Lys Glu Leu Ala Leu Lys Ile Asp Glu Val Leu Ile Ala Pro Val Glu355 360 365 370TAT GAA GAA AAG GTT TTT AAA AAA CTC AAT CAA GCG CTC GTT ATG CCC 1209Tyr Glu Glu Lys Val Phe Lys Lys Leu Asn Gln Ala Leu Val Met Pro
375 380 385TTG TTA GAA AAG TTT AAG CTA GAA TTA AAC AAA GCC AAT TTC AAC GAT 1257Leu Leu Glu Lys Phe Lys Leu Glu Leu Asn Lys Ala Asn Phe Asn Asp
390 395 400GAA AGC GCG CTA GAA AAC GCC ATG CGC CAA ATC ATT GAA GAA GAA AAG 1305Glu Ser Ala Leu Glu Asn Ala Met Arg Gln Ile Ile Glu Glu Glu Lys
405 410 415ATT AAA GCG GGT AGT TTT ATG CAG CCT TTA AGA TTG GCC CTT TTG GGT 1353Ile Lys Ala Gly Ser Phe Met Gln Pro Leu Arg Leu Ala Leu Leu Gly
420 425 430AAG GGA GGC GGG ATA GGC CTT AAA GAA GCG CTT TTT ATT TTA GGC AAA 1401Lys Gly Gly Gly Ile Gly Leu Lys Glu Ala Leu Phe Ile Leu Gly Lys435 440 445 450ACA GAG AGC GTC AAA AGA ATA GAG GAT TTT TTG AAA AAC TAAAAAATTG GC 1452Thr Glu Ser Val Lys Arg Ile Glu Asp Phe Leu Lys Asn
455 460TCTGTTTTCA TTGGGTATTA AAATAAAAGA GTTTGATTTT AGCGGTTGTT AAGCAACTCC 1512TTTTGAAAAA TAAGAGGG 1530
(2) Sequence 718 data:
(i) sequence characteristics:
(A) length: 463 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 718: met Ser Leu Ile Val Thr Arg Phe Ala Pro Ser Pro Thr Gly Tyr Leu 151015 His Ile Gly Gly Leu Arg Thr Ala Ile Phe Asn Tyr Leu Phe Ala Arg
20 25 30Ala Asn Gln Gly Lys Phe Phe Leu Arg Ile Glu Asp Thr Asp Leu Ser
35 40 45Arg Asn Ser Ile Glu Ala Ala Asn Ala Ile Ile Glu Ala Phe Lys Trp
50 55 60Val Gly Leu Glu Tyr Asp Gly Glu Ile Leu Tyr Gln Ser Lys Arg Phe65 70 75 80Glu Ile Tyr Lys Glu Tyr Ile Gln Lys Leu Leu Asp Glu Asp Lys Ala
85 90 95Tyr Tyr Cys Tyr Met Ser Lys Glu Glu Leu Asp Ala Leu Arg Glu Glu
100 105 110Gln Lys Ala Arg Lys Glu Thr Pro Arg Tyr Asp Asn Arg Tyr Arg Asp
115 120 125Phe Lys Gly Thr Pro Pro Lys Gly Ile Glu Pro Val Val Arg Ile Lys
130 135 140Val Pro Gln Asn Glu Val Ile Gly Phe Asn Asp Gly Val Lys Gly Glu145 150 155 160Val Lys Val Asn Thr Asn Glu Leu Asp Asp Phe Ile Ile Ala Arg Ser
165 170 175Asp Gly Thr Pro Thr Tyr Asn Phe Val Val Thr Ile Asp Asp Ala Leu
180 185 190Met Gly Ile Thr Asp Val Ile Arg Gly Asp Asp His Leu Ser Asn Thr
195 200 205Pro Lys Gln Ile Val Leu Tyr Lys Ala Leu Asn Phe Lys Ile Pro Asn
210 215 220Phe Phe His Val Pro Met Ile Leu Asn Glu Glu Gly Gln Lys Leu Ser225 230 235 240Lys Arg His Gly Ala Thr Asn Val Met Asp Tyr Gln Glu Met Gly Tyr
245 250 255Leu Lys Glu Ala Leu Val Asn Phe Leu Ala Arg Leu Gly Trp Ser Tyr
260 265 270Gln Asp Lys Glu Val Phe Ser Met Gln Glu Leu Leu Glu Leu Phe Asp
275 280 285Pro Lys Asp Leu Asn Ser Ser Pro Ser Cys Phe Ser Trp His Lys Leu
290 295 300Asn Trp Leu Asn Ala His Tyr Leu Lys Asn Gln Ser Val Gln Glu Leu305 310 315 320Leu Lys Leu Leu Lys Pro Phe Ser Phe Ser Asp Leu Ser His Leu Asn
325 330 335Pro Thr Gln Leu Asp Arg Leu Leu Asp Ala Leu Lys Glu Arg Ser Gln
340 345 350Thr Leu Lys Glu Leu Ala Leu Lys Ile Asp Glu Val Leu Ile Ala Pro
355 360 365Val Glu Tyr Glu Glu Lys Val Phe Lys Lys Leu Asn Gln Ala Leu Val
370 375 380Met Pro Leu Leu Glu Lys Phe Lys Leu Glu Leu Asn Lys Ala Asn Phe385 390 395 400Asn Asp Glu Ser Ala Leu Glu Asn Ala Met Arg Gln Ile Ile Glu Glu
405 410 415Glu Lys Ile Lys Ala Gly Ser Phe Met Gln Pro Leu Arg Leu Ala Leu
420 425 430Leu Gly Lys Gly Gly Gly Ile Gly Leu Lys Glu Ala Leu Phe Ile Leu
435 440 445Gly Lys Thr Glu Ser Val Lys Arg Ile Glu Asp Phe Leu Lys Asn
450 455 460
(2) Sequence 719 data:
(i) sequence characteristics:
(A) length: 382 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...329
(D) Other information:
(xi) Description of the sequence: sequence 719: CCTAATGATT TTTTCTATCT TGCCCCCCTT ATGTGTTAGA AAATTCTAAA ATG TTT 56
Met Phe
1AAG GGG ATT TAT CCT ATG CGT AAT TTT CCT ATC CAC CAT AAT GGT TTT 104Lys Gly Ile Tyr Pro Met Arg Asn Phe Pro Ile His His Asn Gly Phe
5 10 15AAA CAT GAA GTG TTA GCT CAC ATG CTA AAA AGG CAT AAA GAG CCA TTT 152Lys His Glu Val Leu Ala His Met Leu Lys Arg His Lys Glu Pro Phe
20 25 30ATT TTA AGC TAT AAT GAC TGC GAA TTT GTA AGG AAT GCT TAT AAA GAT 200Ile Leu Ser Tyr Asn Asp Cys Glu Phe Val Arg Asn Ala Tyr Lys Asp35 4045 50TTT AAA ATT TTA GAA CCA TCT TGG CAA TAC ACT ATG GGA CAA GGC GAG 248Phe Lys Ile Leu Glu Pro Ser Trp Gln Tyr Thr Met Gly Gln Gly Glu
55 60 65ATC AGA ATG GGT AAA AAT CGC TTA GAA AGA GGC GAT AAT AAC CAT GTC 296Ile Arg Met Gly Lys Asn Arg Leu Glu Arg Gly Asp Asn Asn His Val
70 75 80AAA CAA TCT CAT GAG TTA TTG ATT ATC AAG GAG TAAAAATGCA TATTAGCGAA 349Lys Gln Ser His Glu Leu Leu Ile Ile Lys Glu
85 90GTCAAAACTG CCTTTAAAAT CGCTGATGTA GAA 382
(2) Sequence 720 data:
(i) sequence characteristics:
(A) length: 93 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 720: met Phe Lys Gly Ile Tyr Pro Met Arg Asn Phe Pro Ile His His Asn 151015 Gly Phe Lys His Glu Val Leu Ala His Met Leu Lys Arg His Lys Glu
20 25 30Pro Phe Ile Leu Ser Tyr Asn Asp Cys Glu Phe Val Arg Asn Ala Tyr
35 40 45Lys Asp Phe Lys Ile Leu Glu Pro Ser Trp Gln Tyr Thr Met Gly Gln
50 55 60Gly Glu Ile Arg Met Gly Lys Asn Arg Leu Glu Arg Gly Asp Asn Asn65 70 75 80His Val Lys Gln Ser His Glu Leu Leu IleIle Lys Glu
85 90
(2) Sequence 721 data:
(i) sequence characteristics:
(A) length: 376 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 183...323
(D) Other information:
(xi) Description of the sequence: sequence 721: ATCCACAAAT TCCACTTCAT TTTCTTTGCA AAATTCAAAA AATTCTTTGA TCTTGCTTTC 60ACTATTTTGA GTTCTTACTA TCATTAACCA CCTTTAATTG TTATGAATTG AGTTTGATTG 120ATAGGGGTGA TTATAGCATT TATGGGGCAA AAAAAGTAGA ATCTGTATCA AGTTTTATTA 180AG ATG CAT GCG GTA AAA TCC GCT AAA TCA AGG AGT GTT ATT ATG GAA 227 Met His Ala Val Lys Ser Ala Lys Ser Arg Ser Val Ile Met Glu
1 5 10 15GCA GAC GCA ACC ACA CTA TTA GGA TTT TTT GAA GAA AAT CAA AAC AAT 275Ala Asp Ala Thr Thr Leu Leu Gly Phe Phe Glu Glu Asn Gln Asn Asn
20 25 30CAA TTT GTC ATT CCT ATC TAT CAG AGG TTG TAT AGT TGG AAA AAG GAA T 324Gln Phe Val Ile Pro Ile Tyr Gln Arg Leu Tyr Ser Trp Lys Lys Glu
35 40 45AATGCGAACA ATTATGGGAT GATATTATAA AAATTGGTGG GAATGATAAG AT 376
(2) Sequence 722 data:
(i) sequence characteristics:
(A) length: 47 aminoacids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 722: met His Ala Val Lys Ser Ala Lys Ser Arg Ser Val Ile Met Glu Ala 151015 Asp Ala Thr Thr Leu Leu Gly Phe Phe Glu Glu Asn Gln Asn Asn Gln
20 25 30Phe Val Ile Pro Ile Tyr Gln Arg Leu Tyr Ser Trp Lys Lys Glu
35 40 45
(2) Sequence 723 data:
(i) sequence characteristics:
(A) length: 1021 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...968
(D) Other information:
(xi) Description of the sequence: sequence 723: TATTAATGGG GTTTGTGGGA TTGAATGCTA GTGATCGTTT GTTAGAAATC ATG CGC 56
Met Arg
1CTT TAT CAA AAA CAA GGC TTG GAA ATG GTG GGT CAA AAG TTG GAT TCT 104Leu Tyr Gln Lys Gln Gly Leu Glu Met Val Gly Gln Lys Leu Asp Ser
510 15TAT TTA GCG GAT AAA TCT TTT TGG GCA GAA GAA CTT CAA AAC AAG GAC 152Tyr Leu Ala Asp Lys Ser Phe Trp Ala Glu Glu Leu Gln Asn Lys Asp
20 25 30ACG GAT TTT GGC TAT TAT CAA AAC AAG CAG TTT TTA TTT GTG GCT AAT 200Thr Asp Phe Gly Tyr Tyr Gln Asn Lys Gln Phe Leu Phe Val Ala Asn35 40 45 50AAA TCC AAG CCC AGT TTG GAG TTT TAT GAG ATA GAA AAT AAC ATG CTT 248Lys Ser Lys Pro Ser Leu Glu Phe Tyr Glu Ile Glu Asn Asn Met Leu
55 60 65AAA AAA ATC AAC AGC TCT AAA GCT CTT GTA GGC TCT AAA AAG GGC GAT 296Lys Lys Ile Asn Ser Ser Lys Ala Leu Val Gly Ser Lys Lys Gly Asp
70 75 80AAG ACT TTA GAG GGC GAT TTG GCC ACG CCT ATT GGA GTG TAT CGT ATC 344Lys Thr Leu Glu Gly Asp Leu Ala Thr Pro Ile Gly Val Tyr Arg Ile
85 90 95ACG CAG AAA TTA GAG CGC TTG GAT CAA TAT TAT GGC GTT TTG GCT TTT 392Thr Gln Lys Leu Glu Arg Leu Asp Gln Tyr Tyr Gly Val Leu Ala Phe
100 105 110GTA ACG AAT TAC CCT AAT TTG TAT GAT ACC TTG AAA AAA CGC ACC GGG 440Val Thr Asn Tyr Pro Asn Leu Tyr Asp Thr Leu Lys Lys Arg Thr Gly115 120 125 130CAT GGC ATT TGG GTG CAT GGA ATG CCT TTA AAT GGC GAT CGG AAT GAA 488His Gly Ile Trp Val His Gly Met Pro Leu Asn Gly Asp Arg Asn Glu
135 140 145TTG AAC ACC AAG GGC TGT ATT GCG ATT GAA AAC CCG CTT TTA AGC TCT 536Leu Asn Thr Lys Gly Cys Ile Ala Ile Glu Asn Pro Leu Leu Ser Ser
150 155 160TAT GAC AAA GTG TTA AAA GGC GAA AAAGCG TTC CTC ATC ACC TAT GAA 584Tyr Asp Lys Val Leu Lys Gly Glu Lys Ala Phe Leu Ile Thr Tyr Glu
165 170 175GAC AAG TTT TTC CCA AGC ACC AAA GAA GAA TTG AGC ATG ATT TTA AGC 632Asp Lys Phe Phe Pro Ser Thr Lys Glu Glu Leu Ser Met Ile Leu Ser
180 185 190TCC CTT TTT CAA TGG AAA GAA GCC TGG GCT AGG GGC GAT TTT GAA CGC 680Ser Leu Phe Gln Trp Lys Glu Ala Trp Ala Arg Gly Asp Phe Glu Arg195 200 205 210TAC ATG CGT TTT TAT AAC CCC AAT TTC ACT CGC TAT GAC GGC ATG AAA 728Tyr Met Arg Phe Tyr Asn Pro Asn Phe Thr Arg Tyr Asp Gly Met Lys
215 220 225TTT AAC GCT TTT AAA GAG TAT AAA AAA AGG GTG TTT GCA AAA AAC GAA 776Phe Asn Ala Phe Lys Glu Tyr Lys Lys Arg Val Phe Ala Lys Asn Glu
230 235 240AAA AAG AAT ATC GCT TTT TCC TCT ATC AAT GTG ATC CCT TAC CCC AAC 824Lys Lys Asn Ile Ala Phe Ser Ser Ile Asn Val Ile Pro Tyr Pro Asn
245 250 255TCT CAG AAC AAA CGC TTG TTT TAT GTG GTG TTT GAC CAA GAT TAT AAA 872Ser Gln Asn Lys Arg Leu Phe Tyr Val Val Phe Asp Gln Asp Tyr Lys
260 265 270GCC TAC CAG CAT AAC AAG CTC TCT TAT AGC TCC AAT TCT CAA AAA GAA 920Ala Tyr Gln His Asn Lys Leu Ser Tyr Ser Ser Asn Ser Gln Lys Glu275 280 285 290CTC TAT ATA GAG ATT GAA AAC AAT CAA GTG TCT ATT ATA ATG GAA AAA T 969Leu Tyr Ile Glu Ile Glu Asn Asn Gln Val Ser Ile Ile Met Glu Lys
295 300 305AAGAAAAATA GGGCTTTGTT TTAATTAGGA TAATCTAAGC GGATTTTTCT AA 1021
(2) Sequence 724 data:
(i) sequence characteristics:
(A) length: 306 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 724: met Arg Leu Tyr Gln Lys Gln Gly Leu Glu Met Val Gly Gln Lys Leu 151015 Asp Ser Tyr Leu Ala Asp Lys Ser Phe Trp Ala Glu Glu Leu Gln Asn
20 25 30Lys Asp Thr Asp Phe Gly Tyr Tyr Gln Asn Lys Gln Phe Leu Phe Val
35 40 45Ala Asn Lys Ser Lys Pro Ser Leu Glu Phe Tyr Glu Ile Glu Asn Asn
50 55 60Met Leu Lys Lys Ile Asn Ser Ser Lys Ala Leu Val Gly Ser Lys Lys65 70 75 80Gly Asp Lys Thr Leu Glu Gly Asp Leu Ala Thr Pro Ile Gly Val Tyr
85 90 95Arg Ile Thr Gln Lys Leu Glu Arg Leu Asp Gln Tyr Tyr Gly Val Leu
100 105 110Ala Phe Val Thr Asn Tyr Pro Asn Leu Tyr Asp Thr Leu Lys Lys Arg
115 120 125Thr Gly His Gly Ile Trp Val His Gly Met Pro Leu Asn Gly Asp Arg
130 135 140Asn Glu Leu Asn Thr Lys Gly Cys Ile Ala Ile Glu Asn Pro Leu Leu145 150 155 160Ser Ser Tyr Asp Lys Val Leu Lys Gly Glu Lys Ala Phe Leu Ile Thr
165170 175Tyr Glu Asp Lys Phe Phe Pro Ser Thr Lys Glu Glu Leu Ser Met Ile
180 185 190Leu Ser Ser Leu Phe Gln Trp Lys Glu Ala Trp Ala Arg Gly Asp Phe
195 200 205Glu Arg Tyr Met Arg Phe Tyr Asn Pro Asn Phe Thr Arg Tyr Asp Gly
210 215 220Met Lys Phe Asn Ala Phe Lys Glu Tyr Lys Lys Arg Val Phe Ala Lys225 230 235 240Asn Glu Lys Lys Asn Ile Ala Phe Ser Ser Ile Asn Val Ile Pro Tyr
245 250 255Pro Asn Ser Gln Asn Lys Arg Leu Phe Tyr Val Val Phe Asp Gln Asp
260 265 270Tyr Lys Ala Tyr Gln His Asn Lys Leu Ser Tyr Ser Ser Asn Ser Gln
275 280 285Lys Glu Leu Tyr Ile Glu Ile Glu Asn Asn Gln Val Ser Ile Ile Met
290 295 300Glu Lys305
(2) Sequence 725 data:
(i) sequence characteristics:
(A) length: 990bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 43...870
(D) Other information:
(xi) Description of the sequence: sequence 725: AAAACAAGCT AAAGAATGGC TCAAATTGTA AAAGGATCTG AC ATG TTT AAA GAT 54
Met Phe Lys Asp
1TTT TAT CGC ACC ACC CTC TCT TTT TTA AAG CCT TTA TTG CTT TTA CTA 102Phe Tyr Arg Thr Thr Leu Ser Phe Leu Lys Pro Leu Leu Leu Leu Leu 5 10 15 20GTT TTA TTA TTG CCG TTT TCA CTT TGT ATA GCT GAT GAA TAT ATT AGC 150Val Leu Leu Leu Pro Phe Ser Leu Cys Ile Ala Asp Glu Tyr Ile Ser
25 30 35ATA AGT GAT GAT TGG GAT GAA ATT GTG CGA AAT CAT AAG ACA TAT TAT 198Ile Ser Asp Asp Trp Asp Glu Ile Val Arg Asn His Lys Thr Tyr Tyr
40 45 50TTT GAA AAT GGT TTA GAC CAT TTT AAT CAA GGC CAA TAC CAG CAA GCC 246Phe Glu Asn Gly Leu Asp His Phe Asn Gln Gly Gln Tyr Gln Gln Ala
55 60 65TTT AAA GAT TTT AGA TTG GCG CAA GAA TAC AGC ATC GGG CTT GGC AGT 294Phe Lys Asp Phe Arg Leu Ala Gln Glu Tyr Ser Ile Gly Leu Gly Ser
70 75 80GTT TAT TTA GCC AAA ATG TAT TTG GAG GGA AAG GGC GTG AAA GTG GAT 342Val Tyr Leu Ala Lys Met Tyr Leu Glu Gly Lys Gly Val Lys Val Asp85 90 95 100TAC AAA AAA GCA CAA TTT TAT GCA GAA AAC GCT ATC AAA GGG TAT GGG 390Tyr Lys Lys Ala Gln Phe Tyr Ala Glu Asn Ala Ile Lys Gly Tyr Gly
105 110 115AGC GGA TTG TTA GGG GGT GCT CTT ATT TTA GGA CGC ATG CAA GCA GAA 438Ser Gly Leu Leu Gly Gly Ala Leu Ile Leu Gly Arg Met Gln Ala Glu
120 125 130GGC TTA GGG ATG AAA AAG GAT TTG AAA CAA GCG CTC AAG ACT TAT AGG486Gly Leu Gly Met Lys Lys Asp Leu Lys Gln Ala Leu Lys Thr Tyr Arg
135 140 145CAT GTG GTT CGC ATG TTT TCT AAT AAA AGC ACA AAT TTT GCT AAC AAT 534His Val Val Arg Met Phe Ser Asn Lys Ser Thr Asn Phe Ala Asn Asn
150 155 160TTT AGA TTA CCA AAC CTT GCG GAA TTT ACT AGT ATG CTT ATT GGA TCG 582Phe Arg Leu Pro Asn Leu Ala Glu Phe Thr Ser Met Leu Ile Gly Ser165 170 175 180CGA TTC ATT GAT CTT TCA GGT TTG AGC GCG AAT CCT ATA AAA TTT GGA 630Arg Phe Ile Asp Leu Ser Gly Leu Ser Ala Asn Pro Ile Lys Phe Gly
185 190 195AAG AAA TTT GGA ATA CTT GTT AAG AAA TCC ACT CAA ATC AAA GAT AAG 678Lys Lys Phe Gly Ile Leu Val Lys Lys Ser Thr Gln Ile Lys Asp Lys
200 205 210ACA CTT CTT TGG GAA GAT ATT GCT GAA ATT TCA AGC AAT ATT ACT TTA 726Thr Leu Leu Trp Glu Asp Ile Ala Glu Ile Ser Ser Asn Ile Thr Leu
215 220 225CTC AAA CAA CAA ATG GGG GAG ATC CTT TAT AGG ATT GGG ATC GCT TAT 774Leu Lys Gln Gln Met Gly Glu Ile Leu Tyr Arg Ile Gly Ile Ala Tyr
230 235 240AAA GAA GGG CTT GGC ACT AGA AAG AAA AAG GAC AGG GCT AAA AAA TTC 822Lys Glu Gly Leu Gly Thr Arg Lys Lys Lys Asp Arg Ala Lys Lys Phe245 250 255 260CTG CAA AAA TCC GCA GAA TTT GGC TAT GAA AAA GCC ATG GAA GCT CTG T 871Leu Gln Lys Ser Ala Glu Phe Gly Tyr Glu Lys Ala Met Glu Ala Leu
265 270 275AGTTTTTTAA TCAAACTTGT ATCAAGCTTG ACTGAATGGG TTAGAAAAAT CCGCTTAGAT 931TATCCTAATT AAAACAAAGC CCTATTTTTC TTATTTTTCC ATTATAATAG ACACTTGAT 990
(2) Sequence 726 data:
(i) sequence characteristics:
(A) length: 276 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 726: met Phe Lys Asp Phe Tyr Arg Thr Thr Leu Ser Phe Leu Lys Pro Leu 151015 Leu Leu Leu Leu Val Leu Leu Leu Pro Phe Ser Leu Cys Ile Ala Asp
20 25 30Glu Tyr Ile Ser Ile Ser Asp Asp Trp Asp Glu Ile Val Arg Asn His
35 40 45Lys Thr Tyr Tyr Phe Glu Asn Gly Leu Asp His Phe Asn Gln Gly Gln
50 55 60Tyr Gln Gln Ala Phe Lys Asp Phe Arg Leu Ala Gln Glu Tyr Ser Ile65 70 75 80Gly Leu Gly Ser Val Tyr Leu Ala Lys Met Tyr Leu Glu Gly Lys Gly
85 90 95Val Lys Val Asp Tyr Lys Lys Ala Gln Phe Tyr Ala Glu Asn Ala Ile
100 105 110Lys Gly Tyr Gly Ser Gly Leu Leu Gly Gly Ala Leu Ile Leu Gly Arg
115 120 125Met Gln Ala Glu Gly Leu Gly Met Lys Lys Asp Leu Lys Gln Ala Leu
130 135 140Lys Thr Tyr Arg His Val Val Arg Met Phe Ser Asn Lys Ser Thr Asn145 150 155 160Phe Ala Asn Asn Phe Arg Leu Pro Asn Leu Ala GluPhe Thr Ser Met
165 170 175Leu Ile Gly Ser Arg Phe Ile Asp Leu Ser Gly Leu Ser Ala Asn Pro
180 185 190Ile Lys Phe Gly Lys Lys Phe Gly Ile Leu Val Lys Lys Ser Thr Gln
195 200 205Ile Lys Asp Lys Thr Leu Leu Trp Glu Asp Ile Ala Glu Ile Ser Ser
210 215 220Asn Ile Thr Leu Leu Lys Gln Gln Met Gly Glu Ile Leu Tyr Arg Ile225 230 235 240Gly Ile Ala Tyr Lys Glu Gly Leu Gly Thr Arg Lys Lys Lys Asp Arg
245 250 255Ala Lys Lys Phe Leu Gln Lys Ser Ala Glu Phe Gly Tyr Glu Lys Ala
260 265 270Met Glu Ala Leu
275
(2) Sequence 727 data:
(i) sequence characteristics:
(A) length: 2685 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...2601
(D) Other information:
(xi) Description of the sequence: sequence 727: TTG GAT TGC GTA TCT CAA GCC AAA ACT GAA GCT GAG AAA AAA GAA TGC 48Leu Asp Cys Val Ser Gln Ala Lys Thr Glu Ala Glu Lys Lys Glu Cys 151015 GAG AAA TTA CTC ACC CCT GAA GCG AGA AAA CTC TTA GAA GAA GCT AAA 96Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu Glu Ala Lys
20 25 30GAG AGC GTT AAA GCT TAT AAA GAC TGC GTA TCA AAA GCT AGG AAT GAA 144Glu Ser Val Lys Ala Tyr Lys Asp Cys Val Ser Lys Ala Arg Asn Glu
35 40 45AAA GAG AAA AAA GAA TGC GAG AAA TTA CTC ACG CCT GAA GCG AAA AAA 192Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Lys Lys
50 55 60CTT TTA GAG CAA CAA GTG CTA GAT TGT TTG AAA AAC GCT AAA ACC GAA 240Leu Leu Glu Gln Gln Val Leu Asp Cys Leu Lys Asn Ala Lys Thr Glu65 70 75 80GCT GAT AAA AAA AGG TGT GTC AAA GAT CTC CCT AAA GAC TTG CAG AAA 288Ala Asp Lys Lys Arg Cys Val Lys Asp Leu Pro Lys Asp Leu Gln Lys
85 90 95AAG GTT TTA GCT AAA GAG AGC GTT AAG GCT TAT TTG GAC TGC GTA TCA 336Lys Val Leu Ala Lys Glu Ser Val Lys Ala Tyr Leu Asp Cys Val Ser
100 105 110AGA GCT AGG AAT GAA AAA GAG AAA AAA GAA TGC GAG AAA TTG CTC ACC 384Arg Ala Arg Asn Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr
115 120 125CCT GAA GCG AAA AAA CTT TTA GAA GAA GCC AAA GAG AGT CTT AAA GCT 432Pro Glu Ala Lys Lys Leu Leu Glu Glu Ala Lys Glu Ser Leu Lys Ala
130 135 140TAT AAA GAC TGC CTC TCT CAA GCT AGA AAT GAA GAA GAA AGG AGA GCT 480Tyr Lys Asp Cys Leu Ser Gln Ala Arg Asn Glu Glu Glu Arg Arg Ala145 150 155 160TGC GAG AAA CTA CTC ACG CCT GAA GCG AGA AAA CTC TTA GAG CAA GAA 528Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu GlnGlu
165 170 175GTT AAG AAA AGC ATT AAG GCT TAT TTG GAC TGC GTA TCA AGA GCT AGG 576Val Lys Lys Ser Ile Lys Ala Tyr Leu Asp Cys Val Ser Arg Ala Arg
180 185 190AAT GAA AAA GAG AAA AAA GAA TGC GAG AAA TTA CTC ACG CCT GAA GCG 624Asn Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala
195 200 205AGA AAA TTT TTA GCG AAG CAA GTG CTA AAT TGT TTG GAA AAA GCT GGA 672Arg Lys Phe Leu Ala Lys Gln Val Leu Asn Cys Leu Glu Lys Ala Gly
210 215 220AAT GAA GAA GAA AGA AAA GCA TGT CTT AAA AAT CTC CCT AAA GAC TTA 720Asn Glu Glu Glu Arg Lys Ala Cys Leu Lys Asn Leu Pro Lys Asp Leu225 230 235 240CAG GAA AAT ATT TTA GCT AAA GAG AGT CTT AAA GCT TAT AAA GAC TGC 768Gln Glu Asn Ile Leu Ala Lys Glu Ser Leu Lys Ala Tyr Lys Asp Cys
245 250 255CTC TCT CAA GCT AGA AAT GAA GAA GAA AGG AGA GCT TGC GAG AAA CTA 816Leu Ser Gln Ala Arg Asn Glu Glu Glu Arg Arg Ala Cys Glu Lys Leu
260 265 270CTC ACG CCT GAA GCG AGA AAA CTC TTA GAG CAA GAA GTT AAG AAA AGC 864Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu Gln Glu Val Lys Lys Ser
275 280 285GTT AAG GCT TAT TTG GAC TGC GTA TCA AGA GCT AGG AAT GAA AAA GAG 912Val Lys Ala Tyr Leu Asp Cys Val Ser Arg Ala Arg Asn Glu Lys Glu
290 295 300AAA AAA GAA TGC GAG AAA TTA CTC ACG CCT GAA GCG AGA AAA TTT TTA 960Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Phe Leu305 310 315 320GCG AAA GAA CTCCAA CAA AAA GAT AAA GCG ATC AAA GAT TGC TTG AAA 1008Ala Lys Glu Leu Gln Gln Lys Asp Lys Ala Ile Lys Asp Cys Leu Lys
325 330 335AAC GCC GAT CCT AAC GAC AGA GCG GCT ATC ATG AAG TGT TTG GAT GGT 1056Asn Ala Asp Pro Asn Asp Arg Ala Ala Ile Met Lys Cys Leu Asp Gly
340 345 350TTG AGC GAT GAA GAG AAG CTC AAA TAC CTG CAA GAA GCT AGA GAA AAG 1104Leu Ser Asp Glu Glu Lys Leu Lys Tyr Leu Gln Glu Ala Arg Glu Lys
355 360 365GCT GTT GCG GAT TGT TTG GCT ATG GCT AAA ACC GAT GAA GAA AAA AGG 1152Ala Val Ala Asp Cys Leu Ala Met Ala Lys Thr Asp Glu Glu Lys Arg
370 375 380AAA TGC CAA AAC CTT TAT AGC GAT TTG ATC CAA GAA ATC CAA AAT AAA 1200Lys Cys Gln Asn Leu Tyr Ser Asp Leu Ile Gln Glu Ile Gln Asn Lys385 390 395 400AGG ACA CAA AAC AAA CAA AAT CAA TTG AGT AAA ACA GAA AGG TTG CAT 1248Arg Thr Gln Asn Lys Gln Asn Gln Leu Ser Lys Thr Glu Arg Leu His
405 410 415CAA GCA AGC GAG TGC TTG GAT AAC TTA GAT GAC CCT ACT GAT CAA GAG 1296Gln Ala Ser Glu Cys Leu Asp Asn Leu Asp Asp Pro Thr Asp Gln Glu
420 425 430GCC ATA GAG CAA TGT TTA GAG GGC TTG AGC GAT AGT GAA AGG GCG CTA 1344Ala Ile Glu Gln Cys Leu Glu Gly Leu Ser Asp Ser Glu Arg Ala Leu
435 440 445ATT CTA GGA ATT AAA CGA CAA GCT GAT GAA GTG GAT CTG ATT TAT AGC 1392Ile Leu Gly Ile Lys Arg Gln Ala Asp Glu Val Asp Leu Ile Tyr Ser
450 455 460GAT CTA AGA AAC CGT AAA ACC TTT GAT AAC ATG GCG GCT AAA GGT TAT 1440Asp Leu Arg Asn Arg Lys Thr Phe Asp Ash Met Ala Ala Lys Gly Tyr465 470 475 480CCA TTG TTA CCA ATG GAT TTC AAA AAT GGC GGC GAT ATT GCC ACT ATT 1488Pro Leu Leu Pro Met Asp Phe Lys Asn Gly Gly Asp Ile Ala Thr Ile
485 490 495AAC GCC ACT AAT GTT GAT GCG GAC AAA ATA GCT AGC GAT AAT CCT ATT 1536Asn Ala Thr Asn Val Asp Ala Asp Lys Ile Ala Ser Asp Asn Pro Ile
500 505 510TAT GCT TCC ATA GAG CCT GAT ATT GCC AAG CAA TAC GAA ACA GAA AAA 1584Tyr Ala Ser Ile Glu Pro Asp Ile Ala Lys Gln Tyr Glu Thr Glu Lys
515 520 525ACC ATT AAG GAT AAG AAT TTA GAA GCT AAA TTA GCT AAG GCT TTA GGT 1632Thr Ile Lys Asp Lys Asn Leu Glu Ala Lys Leu Ala Lys Ala Leu Gly
530 535 540GGC AAT AAA AAA GAT GAC GAT AAA GAA AAA AGT AAA AAA TCC ACA GCA 1680Gly Asn Lys Lys Asp Asp Asp Lys Glu Lys Ser Lys Lys Ser Thr Ala545 550 555 560GAA GCT AAA GCA GAA AAC AAT AAG ATA GAC AAA GAT GTC GCA GAA ACT 1728Glu Ala Lys Ala Glu Asn Asn Lys Ile Asp Lys Asp Val Ala Glu Thr
565 570 575GCC AAG AAT ATC AGT GAA ATC GCT CTT AAG AAC AAA AAA GAA AAG AGT 1776Ala Lys Asn Ile Ser Glu Ile Ala Leu Lys Asn Lys Lys Glu Lys Ser
580 585 590GGG GAA TTT GTA GAT GAA AAT GGT AAT CCC ATT GAT GAC AAA AAG AAA 1824Gly Glu Phe Val Asp Glu Asn Gly Asn Pro Ile Asp Asp Lys Lys Lys
595 600 605GCA GAA AAA CAA GAT GAA ACA AGC CCT GTC AAA CAG GCC TTT ATA GGC 1872Ala Glu Lys Gln Asp Glu Thr Ser Pro Val Lys Gln Ala Phe Ile Gly
610 615 620AAG AGT GAT CCC ACA TTT GTT TTA GCG CAA TAC ACC CCC ATT GAA ATC 1920Lys Ser Asp Pro Thr Phe Val Leu Ala Gln Tyr Thr Pro Ile Glu Ile625 630 635 640ACT CTG ACT TCT AAA GTA GAT GCC ACT CTC ACA GGT ATA GTG AGT GGG 1968Thr Leu Thr Ser Lys Val Asp Ala Thr Leu Thr Gly Ile Val Ser Gly
645 650 655GTT GTA GCC AAA GAT GTA TGG AAC ATG AAC GGC ACT ATG ATC TTA TTA 2016Val Val Ala Lys Asp Val Trp Asn Met Asn Gly Thr Met Ile Leu Leu
660 665 670GAC AAA GGC ACT AAG GTG TAT GGG AAT TAT CAA AGC GTG AAA GGT GGC 2064Asp Lys Gly Thr Lys Val Tyr Gly Asn Tyr Gln Ser Val Lys Gly Gly
675 680 685ACA CCC ATT ATG ACA CGC TTA ATG ATA GTC TTT ACT AAA GCC ATT ACG 2112Thr Pro Ile Met Thr Arg Leu Met Ile Val Phe Thr Lys Ala Ile Thr
690 695 700CCT GAT GGT GTG ATA ATA CCT CTA GCA AAC GCT CAA GCA GCA GGC ATG 2160Pro Asp Gly Val Ile Ile Pro Leu Ala Asn Ala Gln Ala Ala Gly Met705 710 715 720TTG GGT GAA GCA GGG GTA GAT GGC TAT GTG AAT AAT CAC TTT ATG AAG 2208Leu Gly Glu Ala Gly Val Asp Gly Tyr Val Asn Asn His Phe Met Lys
725 730 735CGC ATA GGC TTT GCT GTG ATA GCA AGC GTG GTT AAT AGC TTC TTG CAA 2256Arg Ile Gly Phe Ala Val Ile Ala Ser Val Val Asn Ser Phe Leu Gln
740 745 750ACT GCG CCT ATC ATA GCT CTA GAT AAA CTC ATA GGC CTT GGC AAA GGT 2304Thr Ala Pro Ile Ile Ala Leu Asp Lys Leu Ile Gly Leu Gly Lys Gly
755 760 765AGA AGTGAA AGG ACA CCT GAA TTT AAT TAC GCT TTG GGT CAA GCT ATC 2352Arg Ser Glu Arg Thr Pro Glu Phe Asn Tyr Ala Leu Gly Gln Ala Ile
770 775 780AAT GGT AGC ATG CAA AGT TCA GCT CAG ATG TCT AAT CAA ATT CTA GGG 2400Asn Gly Ser Met Gln Ser Ser Ala Gln Met Ser Asn Gln Ile Leu Gly785 790 795 800CAA CTG ATG AAT ATC CCC CCA ACT TTT TAC AAA AAC GAG GGC GAT AGT 2448Gln Leu Met Asn Ile Pro Pro Ser Phe Tyr Lys Asn Glu Gly Asp Ser
805 810 815ATT AAG ATT CTC ACA ATG GAC GAT ATT GAT TTT AGC GGT GTG TAT GAT 2496Ile Lys Ile Leu Thr Met Asp Asp Ile Asp Phe Ser Gly Val Tyr Asp
820 825 830GTT AAA ATT ACT AAC AAA TCT GTG GTA GAT GAA ATT ATC AAA CAA AGC 2544Val Lys Ile Thr Asn Lys Ser Val Val Asp Glu Ile Ile Lys Gln Ser
835 840 845ACC AAA ACT TTG TCT AGA GAA CAT GAA GAA ATC ACC ACA AGC CCC AAA 2592Thr Lys Thr Leu Ser Arg Glu His Glu Glu Ile Thr Thr Ser Pro Lys
850 855 860GGT GGC AAT TAATTCAAGA GAAAGGATAA AATATATTCA TGTTACTAAA CTCGGTTCT 2650Gly Gly Asn865TTACAAAATA AAAGACAAAAA CCAACAACAG GCTCT 2685
(2) Sequence 728 data:
(i) sequence characteristics:
(A) length: 867 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 728: leu Asp Cys Val Ser Gln Ala Lys Thr Glu Ala Glu Lys Lys Glu Cys 151015 Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu Glu Ala Lys
20 25 30Glu Ser Val Lys Ala Tyr Lys Asp Cys Val Ser Lys Ala Arg Asn Glu
35 40 45Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Lys Lys
50 55 60Leu Leu Glu Gln Gln Val Leu Asp Cys Leu Lys Asn Ala Lys Thr Glu65 70 75 80Ala Asp Lys Lys Arg Cys Val Lys Asp Leu Pro Lys Asp Leu Gln Lys
85 90 95Lys Val Leu Ala Lys Glu Ser Val Lys Ala Tyr Leu Asp Cys Val Ser
100 105 110Arg Ala Arg Asn Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr
115 120 125Pro Glu Ala Lys Lys Leu Leu Glu Glu Ala Lys Glu Ser Leu Lys Ala
130 135 140Tyr Lys Asp Cys Leu Ser Gln Ala Arg Asn Glu Glu Glu Arg Arg Ala145 150 155 160Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu Gln Glu
165 170 175Val Lys Lys Ser Ile Lys Ala Tyr Leu Asp Cys Val Ser Arg Ala Arg
180 185 190Asn Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala
195 200 205Arg Lys Phe Leu Ala Lys Gln Val Leu Asn Cys Leu Glu Lys Ala Gly
210 215 220Asn Glu Glu Glu Arg Lys Ala Cys Leu Lys Asn Leu Pro Lys Asp Leu225 230 235 240Gln Glu Asn Ile Leu Ala Lys Glu Ser Leu Lys Ala Tyr Lys Asp Cys
245 250 255Leu Ser Gln Ala Arg Asn Glu Glu Glu Arg Arg Ala Cys Glu Lys Leu
260 265 270Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu Gln Glu Val Lys Lys Ser
275 280 285Val Lys Ala Tyr Leu Asp Cys Val Ser Arg Ala Arg Asn Glu Lys Glu
290 295 300Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Phe Leu305 310 315 320Ala Lys Glu Leu Gln Gln Lys Asp Lys Ala Ile Lys Asp Cys Leu Lys
325 330 335Asn Ala Asp Pro Asn Asp Arg Ala Ala Ile Met Lys Cys Leu Asp Gly
340 345 350Leu Ser Asp Glu Glu Lys Leu Lys Tyr Leu Gln Glu Ala Arg Glu Lys
355 360 365Ala Val Ala Asp Cys Leu Ala Met Ala Lys Thr Asp Glu Glu Lys Arg
370 375 380Lys Cys Gln Asn Leu Tyr Ser Asp Leu Ile Gln Glu Ile Gln Asn Lys385 390 395 400Arg Thr Gln Asn Lys Gln Asn Gln Leu Ser Lys Thr Glu Arg Leu His
405 410 415Gln Ala Ser Glu Cys Leu Asp Asn Leu Asp Asp Pro Thr Asp Gln Glu
420 425 430Ala Ile Glu Gln Cys Leu Glu Gly Leu Ser Asp Ser Glu Arg Ala Leu
435 440 445Ile Leu Gly Ile Lys Arg Gln Ala Asp Glu ValAsp Leu Ile Tyr Ser
450 455 460Asp Leu Arg Asn Arg Lys Thr Phe Asp Asn Met Ala Ala Lys Gly Tyr465 470 475 480Pro Leu Leu Pro Met Asp Phe Lys Asn Gly Gly Asp Ile Ala Thr Ile
485 490 495Asn Ala Thr Asn Val Asp Ala Asp Lys Ile Ala Ser Asp Asn Pro Ile
500 505 510Tyr Ala Ser Ile Glu Pro Asp Ile Ala Lys Gln Tyr Glu Thr Glu Lys
515 520 525Thr Ile Lys Asp Lys Asn Leu Glu Ala Lys Leu Ala Lys Ala Leu Gly
530 535 540Gly Asn Lys Lys Asp Asp Asp Lys Glu Lys Ser Lys Lys Ser Thr Ala545 550 555 560Glu Ala Lys Ala Glu Asn Asn Lys Ile Asp Lys Asp Val Ala Glu Thr
565 570 575Ala Lys Asn Ile Ser Glu Ile Ala Leu Lys Asn Lys Lys Glu Lys Ser
580 585 590Gly Glu Phe Val Asp Glu Asn Gly Asn Pro Ile Asp Asp Lys Lys Lys
595 600 605Ala Glu Lys Gln Asp Glu Thr Ser Pro Val Lys Gln Ala Phe Ile Gly
610 615 620Lys Ser Asp Pro Thr Phe Val Leu Ala Gln Tyr Thr Pro Ile Glu Ile625 630 635 640Thr Leu Thr Ser Lys Val Asp Ala Thr Leu Thr Gly lle Val Ser Gly
645 650 655Val Val Ala Lys Asp Val Trp Asn Met Asn Gly Thr Met lle Leu Leu
660 665 670Asp Lys Gly Thr Lys Val Tyr Gly AsnTyr Gln Ser Val Lys Gly Gly
675 680 685Thr Pro Ile Met Thr Arg Leu Met Ile Val Phe Thr Lys Ala Ile Thr
690 695 700Pro Asp Gly Val Ile Ile Pro Leu Ala Asn Ala Gln Ala Ala Gly Met705 710 715 720Leu Gly Glu Ala Gly Val Asp Gly Tyr Val Asn Asn His Phe Met Lys
725 730 735Arg Ile Gly Phe Ala Val Ile Ala Ser Val Val Asn Ser Phe Leu Gln
740 745 750Thr Ala Pro Ile Ile Ala Leu Asp Lys Leu Ile Gly Leu Gly Lys Gly
755 760 765Arg Ser Glu Arg Thr Pro Glu Phe Asn Tyr Ala Leu Gly Gln Ala lle
770 775 780Asn Gly Ser Met Gln Ser Ser Ala Gln Met Ser Asn Gln Ile Leu Gly785 790 795 800Gln Leu Met Asn Ile Pro Pro Ser Phe Tyr Lys Asn Glu Gly Asp Ser
805 810 815Ile Lys Ile Leu Thr Met Asp Asp Ile Asp Phe Ser Gly Val Tyr Asp
820 825 830Val Lys Ile Thr Asn Lys Ser Val Val Asp Glu Ile Ile Lys Gln Ser
835 840 845Thr Lys Thr Leu Ser Arg Glu His Glu Glu Ile Thr Thr Ser Pro Lys
850 855 860Gly Gly Asn865
(2) Sequence 729 data:
(i) sequence characteristics:
(A) length: 877 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 65...688
(D) Other information:
(xi) Description of the sequence: sequence 729: TTTGGTGGCA CTAATGGTGT TGTGATTTTC AAAAAAGCCT AGTTTTACAA AGTTAGGATT 60TTGA ATG GCC GTT TAT TTA GAT TTT GAA AAT CAT ATT AAA GAG ATT CAA 109
Met Ala Val Tyr Leu Asp Phe Glu Asn His Ile Lys Glu Ile Gln
1 5 10 15AAT GAA ATT GAA TTA GCC CTT ATT AGA GGC GAT GAG GAC GCT AAA GAA 157Asn Glu Ile Glu Leu Ala Leu Ile Arg Gly Asp Glu Asp Ala Lys Glu
20 25 30ATC TTA GAA AAA AGA TTG GAT AAG GAG GTT AAA AGC ATT TAT TCC AAT 205Ile Leu Glu Lys Arg Leu Asp Lys Glu Val Lys Ser Ile Tyr Ser Asn
35 40 45CTC ACT GAT TTT CAA AAA CTC CAA TTA GCA AGA CAC CCT GAC AGA CCC 253Leu Thr Asp Phe Gln Lys Leu Gln Leu Ala Arg His Pro Asp Arg Pro
50 55 60TAC GCT ATG GAT TAC ATT GAT CTC ATC TTA AAA GAT AAA TAT GAA GTC 301Tyr Ala Met Asp Tyr Ile Asp Leu Ile Leu Lys Asp Lys Tyr Glu Val
65 70 75TTT GGG GAT AGG CAT TAT AAC GAT GAT AAA GCG ATC GTG TGC TTT GTA 349Phe Gly Asp Arg His Tyr Asn Asp Asp Lys Ala Ile Val Cys Phe Val80 85 90 95GGG AAA ATT GAT AAT GTC CCA GTT GTG GTG ATC GGA GAA GAA AAG GGC 397Gly Lys Ile Asp Asn Val Pro Val Val ValIle Gly Glu Glu Lys Gly
100 105 110AGA GGG ACT AAA AAC AAA CTC TTA AGA AAT TTT GGC ATG CCT AAC CCT 445Arg Gly Thr Lys Asn Lys Leu Leu Arg Asn Phe Gly Met Pro Asn Pro
115 120 125TGT GGC TAT CGT AAG GCT TTG AAA ATG GCA AAG TTT GCT GAA AAG TTT 493Cys Gly Tyr Arg Lys Ala Leu Lys Met Ala Lys Phe Ala Glu Lys Phe
130 135 140AAT TTG CCT ATT TTA ATG CTT GTG GAT ACA GCC GGG GCG TAT CCG GGG 541Asn Leu Pro Ile Leu Met Leu Val Asp Thr Ala Gly Ala Tyr Pro Gly
145 150 155ATT GGT GCA GAA GAA AGG GGG CAA AGT GAA GCG ATC GCT AAA AAT CTC 589Ile Gly Ala Glu Glu Arg Gly Gln Ser Glu Ala Ile Ala Lys Asn Leu160 165 170 175CAA GAG TTC GCC TCT TTA AAA GTC CCT ACT ATT TCT GTA ATT ATC GGT 637Gln Glu Phe Ala Ser Leu Lys Val Pro Thr Ile Ser Val Ile Ile Gly
180 185 190GAG GGG GGC AGT GGT GGT GCG CTA CGA TTG CAG TGG CTG ACA AAT TGG 685Glu Gly Gly Ser Gly Gly Ala Leu Arg Leu Gln Trp Leu Thr Asn Trp
195 200 205CTA TGATGGAATA TTCCATTTTT AGCGTTATAT CCCCAGAAGG TTGTGCGGCG ATTCTT 744LeuTGGGATGACC CTAGCAAGAC TGAAGTGGCT ATTAAAGCGA TGAAAATCAC GCCTAGAGAC 804TTAAAGGAGG CGGGGCTTAT TGATGATATT ATCTTAGAGC CTAGCAAAGG GGCTCATAGA 864GACAAATTTT CAG 877
(2) Sequence 730 data:
(i) sequence characteristics:
(A) length: 208 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 730: met Ala Val Tyr Leu Asp Phe Glu Asn His Ile Lys Glu Ile Gln Asn 151015 Glu Ile Glu Leu Ala Leu Ile Arg Gly Asp Glu Asp Ala Lys Glu Ile
20 25 30Leu Glu Lys Arg Leu Asp Lys Glu Val Lys Ser Ile Tyr Ser Asn Leu
35 40 45Thr Asp Phe Gln Lys Leu Gln Leu Ala Arg His Pro Asp Arg Pro Tyr
50 55 60Ala Met Asp Tyr Ile Asp Leu Ile Leu Lys Asp Lys Tyr Glu Val Phe65 70 75 80Gly Asp Arg His Tyr Asn Asp Asp Lys Ala Ile Val Cys Phe Val Gly
85 90 95Lys Ile Asp Asn Val Pro Val Val Val Ile Gly Glu Glu Lys Gly Arg
100 105 110Gly Thr Lys Asn Lys Leu Leu Arg Asn Phe Gly Met Pro Asn Pro Cys
115 120 125Gly Tyr Arg Lys Ala Leu Lys Met Ala Lys Phe Ala Glu Lys Phe Asn
130 135 140Leu Pro Ile Leu Met Leu Val Asp Thr Ala Gly Ala Tyr Pro Gly Ile145 150 155 160Gly Ala Glu Glu Arg Gly Gln Ser Glu Ala Ile Ala Lys Asn Leu Gln
165 170 175Glu Phe Ala Ser Leu Lys Val Pro Thr Ile Ser Val Ile Ile Gly Glu
180 185 190Gly Gly Ser Gly Gly Ala Leu Arg Leu Gln Trp Leu Thr Asn Trp Leu
195 200 205
(2) Sequence 731 data:
(i) sequence characteristics:
(A) length: 804 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 67...744
(D) Other information:
(xi) Description of the sequence: sequence 731: AAGGCGTTAT GAGTCAAGAC TATAATAGAC TTTAAGAAAA ATTTAAAAAT TAAGGATTAT 60TGAATA ATG CAA TTC ACA GGG AAA AAT GTT CTC ATT ACT GGG GCT TCT 108
Met Gln Phe Thr Gly Lys Asn Val Leu Ile Thr Gly Ala Ser
1 5 10AAA GGC ATT GGG GCT GAA ATC GCC AAA ACT CTC GCT TCT ATG GGG CTG 156Lys Gly Ile Gly Ala Glu Ile Ala Lys Thr Leu Ala Ser Met Gly Leu15 20 25 30AAA GTT TGG ATC AAT TAC CGC AGT AAT GCT GAA GTG GCT GAC GCT TTG 204Lys Val Trp Ile Asn Tyr Arg Ser Asn Ala Glu Val Ala Asp Ala Leu
35 40 45AAA AAT GAG CTT GAA GAA AAA GGC TAT AAG GCA GCT GTC ATT AAA TTT 252Lys Asn Glu Leu Glu Glu Lys Gly Tyr Lys Ala Ala Val Ile Lys Phe
50 55 60GAT GCG GCT TCT GAA AGC GAT TTT ATT GAA GCG ATA CAA ACC ATC GTC 300Asp Ala Ala Ser Glu Ser Asp Phe Ile Glu Ala Ile Gln Thr Ile Val
6570 75CAA AGC GAT GGG GGG TTG TCT TAC TTG GTG AAT AAC GCC GGT GTG GTG 348Gln Ser Asp Gly Gly Leu Ser Tyr Leu Val Asn Asn Ala Gly Val Val
80 85 90CGC GAT AAA TTA GCG ATC AAA ATG AAA ACA GAA GAC TTT CAC CAT GTC 396Arg Asp Lys Leu Ala Ile Lys Met Lys Thr Glu Asp Phe His His Val95 100 105 110ATA GAC AAT AAC CTC ACT TCA GCC TTT ATA GGT TGC CGA GAG GCT TTA 444Ile Asp Asn Asn Leu Thr Ser Ala Phe Ile Gly Cys Arg Glu Ala Leu
115 120 125AAG GTG ATG AGC AAG AGT CGT TTT GGG AGC GTG GTC AAT GTC GCT TCT 492Lys Val Met Ser Lys Ser Arg Phe Gly Ser Val Val Asn Val Ala Ser
130 135 140ATC ATT GGT GAA AGA GGC AAT ATG GGG CAG ACA AAC TAC TCA GCG AGT 540Ile Ile Gly Glu Arg Gly Asn Met Gly Gln Thr Asn Tyr Ser Ala Ser
145 150 155AAG GGG GGA ATG ATT GCA ATG AGC AAG TCC TTT GCT TAT GAG GGA GCT 588Lys Gly Gly Met Ile Ala Met Ser Lys Ser Phe Ala Tyr Glu Gly Ala
160 165 170TTA AGG AAT ATT CGT TTC AAC TCT GTA ACG CCC GGT TTT ATA GAA ACC 636Leu Arg Asn Ile Arg Phe Asn Ser Val Thr Pro Gly Phe Ile Glu Thr175 180 185 190GAC ATG AAC GCC AAT TTG AAA GAC GAA CTC AAA GCG GAT TAT GTT AAA 684Asp Met Asn Ala Asn Leu Lys Asp Glu Leu Lys Ala Asp Tyr Val Lys
195 200 205AAC ATT CCT TTA AAC AGG CTA GGG TCT GCT AAG GAA GTG GCA GAA GCG 732Asn Ile Pro Leu Asn Arg Leu Gly Ser Ala Lys Glu Val Ala Glu Ala
210 215 220GTA GGN TTC TTT TGAGTGATCA CTCTAGTTAC ATCACTGGAG AGACTCTCAA AGTCA 789Val Xaa Phe Phe
225ATGGCGGGCT TTATA 804
(2) Sequence 732 data:
(i) sequence characteristics:
(A) length: 226 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 732: met Gln Phe Thr Gly Lys Asn Val Leu Ile Thr Gly Ala Ser Lys Gly 151015 Ile Gly Ala Glu Ile Ala Lys Thr Leu Ala Ser Met Gly Leu Lys Val
20 25 30Trp Ile Asn Tyr Arg Ser Asn Ala Glu Val Ala Asp Ala Leu Lys Asn
35 40 45Glu Leu Glu Glu Lys Gly Tyr Lys Ala Ala Val Ile Lys Phe Asp Ala
50 55 60Ala Ser Glu Ser Asp Phe Ile Glu Ala Ile Gln Thr Ile Val Gln Ser65 70 75 80Asp Gly Gly Leu Ser Tyr Leu Val Asn Asn Ala Gly Val Val Arg Asp
85 90 95Lys Leu Ala Ile Lys Met Lys Thr Glu Asp Phe His His Val Ile Asp
100 105 110Asn Asn Leu Thr Ser Ala Phe Ile Gly Cys Arg Glu Ala Leu Lys Val
115 120 125Met Ser Lys Ser Arg Phe Gly Ser Val Val Asn Val Ala Ser Ile Ile
130 135 140Gly Glu Arg Gly Asn Met GlyGln Thr Asn Tyr Ser Ala Ser Lys Gly145 150 155 160Gly Met Ile Ala Met Ser Lys Ser Phe Ala Tyr Glu Gly Ala Leu Arg
165 170 175Asn Ile Arg Phe Asn Ser Val Thr Pro Gly Phe Ile Glu Thr Asp Met
180 185 190Asn Ala Asn Leu Lys Asp Glu Leu Lys Ala Asp Tyr Val Lys Asn Ile
195 200 205Pro Leu Asn Arg Leu Gly Ser Ala Lys Glu Val Ala Glu Ala Val Xaa
210 215 220Phe Phe225
(2) Sequence 733 data:
(i) sequence characteristics:
(A) length: 373 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 103...312
(D) Other information:
(xi) Description of the sequence: sequence 733: GAAAATTCTT GACACCCAGT TAATTCGTCT TATATAATAC TATTTCATTT GTAGCCATTG 60TTAAGCAATG ATTTTAAGCT ATGGAAAAGA GGTGATAGCA GT ATG CCA GGG ATT 114
Met Pro Gly Ile
1AAG GTT AGA GAA GGC GAT GCG TTT GAT GAA GCT TAT AGG AGA TTC AAA 162Lys Val Arg Glu Gly Asp Ala Phe Asp Glu Ala Tyr Arg Arg Phe Lys 5 10 15 20AAG CAAACC GAT CGC AAT TTA GTG GTA ACA GAA TGC CGT GCT AGA AGG 210Lys Gln Thr Asp Arg Asn Leu Val Val Thr Glu Cys Arg Ala Arg Arg
25 30 35TTC TTT GAG TCT AAG ACT GAA AAA CGC AAA AAA CAA AAA ATC AGC GCT 258Phe Phe Glu Ser Lys Thr Glu Lys Arg Lys Lys Gln Lys Ile Ser Ala
40 45 50AAA AAG AAG GTT TTG AAG CGT CTT TAT ATG TTA AGG CGT TAT GAG TCA 306Lys Lys Lys Val Leu Lys Arg Leu Tyr Met Leu Arg Arg Tyr Glu Ser
55 60 65AGA CTA TAATAGACTT TAAGAAAAAT TTAAAAATTA AGGATTATTG AATAATGCAA TT 364Arg Leu
70CACAGGGAA 373
(2) Sequence 734 data:
(i) sequence characteristics:
(A) length: 70 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(v) Fragment type: inner part
(xi) Description of the sequence: sequence 734: met Pro Gly Ile Lys Val Arg Glu Gly Asp Ala Phe Asp Glu Ala Tyr 151015 Arg Arg Phe Lys Lys Gln Thr Asp Arg Asn Leu Val Val Thr Glu Cys
20 25 30Arg Ala Arg Arg Phe Phe Glu Ser Lys Thr Glu Lys Arg Lys Lys Gln
35 40 45Lys Ile Ser Ala Lys Lys Lys Val Leu Lys Arg Leu Tyr Met Leu Arg
50 55 60Arg Tyr Glu Ser Arg Leu65 70
(2) Sequence 735 data:
(i) sequence characteristics:
(A) length: 1613 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 64...1551
(D) Other information:
(xi) Description of the sequence: sequence 735: TAAGAAAAAC CGCTAGAGTG CAATACAATT CTTGAAAGAT ATGAAATTAA AAAAGGAGAC 60TTT ATG TTA AAA ATC AAA TTA GAA AAA ACC ACT TTT GAA AAC GCA AAA 108
Met Leu Lys Ile Lys Leu Glu Lys Thr Thr Phe Glu Asn Ala Lys
1 5 10 15GCT GAA TGC AGT TTA GTT TTT ATT ATC AAT AAG GAT TTT AGC CAC GCT 156Ala Glu Cys Ser Leu Val Phe Ile Ile Asn Lys Asp Phe Ser His Ala
20 25 30TGG GTC AAA AAT AAA GAG TTG CTA GAA ACC TTT AAA TAC GAA GGC GAA 204Trp Val Lys Asn Lys Glu Leu Leu Glu Thr Phe Lys Tyr Glu Gly Glu
35 40 45GGC GTA TTT TTA GAC CAA GAA AAT AAA ATC CTG TAT GCG GGC GTT AAA 252Gly Val Phe Leu Asp Gln Glu Asn Lys Ile Leu Tyr Ala Gly Val Lys
50 55 60GAA GAT GAT GTG CAT TTA TTG AGA GAG AGC GCG TGT TTA GCC GTT CGC 300Glu Asp Asp Val His Leu Leu Arg Glu Ser Ala Cys Leu Ala Val Arg
65 70 75ACC CTT AAA AAA CTC GCT TTT AAA AGC GTT AAA GTG GGC GTT TAT ACT 348Thr Leu Lys Lys Leu Ala Phe Lys Ser Val Lys Val Gly Val Tyr Thr80 85 90 95TGT GGT GCA CAT TCT AAA GAT AAC GCG CTT TTA GAA AAC TTG AAA GCG 396Cys Gly Ala His Ser Lys Asp Asn Ala Leu Leu Glu Asn Leu Lys Ala
100 105 110CTG TTT TTG GGC TTG AAA TTA GGT TTG TAT GAA TAC GAC ACT TTT AAA 444Leu Phe Leu Gly Leu Lys Leu Gly Leu Tyr Glu Tyr Asp Thr Phe Lys
115 120 125TCC AAC AAA AAA GAA AGC GTT TTA AAA GAA GCC ATT GTC GCT TTA GAA 492Ser Asn Lys Lys Glu Ser Val Leu Lys Glu Ala Ile Val Ala Leu Glu
130 135 140TTG CAC AAA CCT TGC GAA AAA ACT TGC GCA AAT TCT TTA GAA AAG AGT 540Leu His Lys Pro Cys Glu Lys Thr Cys Ala Asn Ser Leu Glu Lys Ser
145 150 155GCT AAA GAA GCG TTA AAA TAC GCT GAA ATC ATG ACA GAA AGC TTG AAT 588Ala Lys Glu Ala Leu Lys Tyr Ala Glu Ile Met Thr Glu Ser Leu Asn160 165 170 175ATC GTT AAA GAT CTA GTC AAT ACC CCC CCT ATG ATT GGC ACT CCG GTT 636Ile Val Lys Asp Leu Val Asn Thr Pro Pro Met Ile Gly Thr Pro Val
180 185 190TAT ATG GCT GAA GTG GCG CAA AAA GTG GCT AAA GAA AAC CAT TTA GAA 684Tyr Met Ala Glu Val Ala Gln Lys Val Ala Lys Glu Asn His Leu Glu
195 200 205ATC CAT GTT CAT GAT GAA AAA TTT TTA GAA GAA AAG AAA ATG AAC GCC 732Ile His Val His Asp Glu Lys Phe Leu Glu Glu Lys Lys Met Asn Ala
210 215 220TTT TTA GCG GTC AAT AAA GCC TCT CTT AGC GTC AAT CCT CCT CGC TTG 780Phe Leu Ala Val Asn Lys Ala Ser Leu Ser Val Asn Pro ProArg Leu
225 230 235ATC CAT TTA GTC TAT AAG CCT AAA AAA GCG AAG AAA AAA ATC GCT TTA 828Ile His Leu Val Tyr Lys Pro Lys Lys Ala Lys Lys Lys Ile Ala Leu240 245 250 255GTG GGT AAG GGC TTG ACT TAT GAT TGT GGG GGT TTG AGC TTG AAA CCG 876Val Gly Lys Gly Leu Thr Tyr Asp Cys Gly Gly Leu Ser Leu Lys Pro
260 265 270GCC GAT TAC ATG GTT ACT ATG AAA GCG GAT AAA GGC GGT GGC TCT GCG 924Ala Asp Tyr Met Val Thr Met Lys Ala Asp Lys Gly Gly Gly Ser Ala
275 280 285GTG ATT GGG CTT TTA AAC GCA TTA GCC AAA CTA GGC GTG GAG GCT GAA 972Val Ile Gly Leu Leu Asn Ala Leu Ala Lys Leu Gly Val Glu Ala Glu
290 295 300GTG CAT GGC ATT ATT GGG GCT ACA GAA AAC ATG ATA GGC CCA GCC GCT 1020Val His Gly Ile Ile Gly Ala Thr Glu Asn Met Ile Gly Pro Ala Ala
305 310 315TAT AAA CCA GAT GAT ATT TTG ATC TCC AAA GAA GGC AAG AGC ATA GAG 1068Tyr Lys Pro Asp Asp Ile Leu Ile Ser Lys Glu Gly Lys Ser Ile Glu320 325 330 335GTC CGT AAT ACC GAC GCT GAG GGG CGT TTG GTT TTA GCG GAT TGT TTG 1116Val Arg Asn Thr Asp Ala Glu Gly Arg Leu Val Leu Ala Asp Cys Leu
340 345 350AGC TAC GCT CAA GAT TTA AAC CCT GAT GTG ATC GTG GAT TTT GCG ACC 1164Ser Tyr Ala Gln Asp Leu Asn Pro Asp Val Ile Val Asp Phe Ala Thr
355 360 365CTT ACT GGG GCA TGC GTT GTA GGC TTA GGC GAA TTC ACT TCA GCG ATC 1212Leu Thr Gly Ala Cys Val Val Gly Leu Gly Glu Phe Thr Ser Ala Ile
370 375380ATG GGG CAT AAT GAA GAG TTA AAA AAC CTC TTT GAA ACT TCA GGG TTA 1260Met Gly His Asn Glu Glu Leu Lys Asn Leu Phe Glu Thr Ser Gly Leu
385 390 395GAA TCC GGC GAA TTA TTA GCC AAA CTC CCC TTT AAC CGC CAT TTA AAG 1308Glu Ser Gly Glu Leu Leu Ala Lys Leu Pro Phe Asn Arg His Leu Lys400 405 410 415AAA TTG ATT GAA TCT AAA ATC GCT GAT GTG TGC AAT ATT TCT TCT TCA 1356Lys Leu Ile Glu Ser Lys Ile Ala Asp Val Cys Asn Ile Ser Ser Ser
420 425 430CGC TAT GGC GGT GCG ATC ACA GCG GGC TTG TTT TTA AAT GAA TTT ATT 1404Arg Tyr Gly Gly Ala Ile Thr Ala Gly Leu Phe Leu Asn Glu Phe Ile
435 440 445AGA GAT GAG TTT AAG GAT AAG TGG CTA CAC ATT GAC ATT GCA GGC CCT 1452Arg Asp Glu Phe Lys Asp Lys Trp Leu His Ile Asp Ile Ala Gly Pro
450 455 460GCT TAT GTG GAA AAA GAA TGG GAT GTG AAT AGC TTT GGA GCG AGT GGG 1500Ala Tyr Val Glu Lys Glu Trp Asp Val Asn Ser Phe Gly Ala Ser Gly
465 470 475GCT GGC GTG AGA GCT TGC ACA GCT TTT GTG GAA GAG CTT TTG AAA AAG 1548Ala Gly Val Arg Ala Cys Thr Ala Phe Val Glu Glu Leu Leu Lys Lys480 485 490 495GCT TGAAATGGGC TTGTCTGTAG GCATTGTGGG TTTGCCTAAT GTGGGCAAAT CCAGCA 1607AlaCCTTTA 1613
(2) Sequence 736 data:
(i) sequence characteristics:
(A) length: 496 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 736: met Leu Lys Ile Lys Leu Glu Lys Thr Thr Phe Glu Asn Ala Lys Ala 151015 Glu Cys Ser Leu Val Phe Ile Ile Asn Lys Asp Phe Ser His Ala Trp
20 25 30Val Lys Asn Lys Glu Leu Leu Glu Thr Phe Lys Tyr Glu Gly Glu Gly
35 40 45Val Phe Leu Asp Gln Glu Asn Lys Ile Leu Tyr Ala Gly Val Lys Glu
50 55 60Asp Asp Val His Leu Leu Arg Glu Ser Ala Cys Leu Ala Val Arg Thr65 70 75 80Leu Lys Lys Leu Ala Phe Lys Ser Val Lys Val Gly Val Tyr Thr Cys
85 90 95Gly Ala His Ser Lys Asp Asn Ala Leu Leu Glu Asn Leu Lys Ala Leu
100 105 110Phe Leu Gly Leu Lys Leu Gly Leu Tyr Glu Tyr Asp Thr Phe Lys Ser
115 120 125Asn Lys Lys Glu Ser Val Leu Lys Glu Ala Ile Val Ala Leu Glu Leu
130 135 140His Lys Pro Cys Glu Lys Thr Cys Ala Asn Ser Leu Glu Lys Ser Ala145 150 155 160Lys Glu Ala Leu Lys Tyr Ala Glu Ile Met Thr Glu Ser Leu Asn Ile
165 170 175Val Lys Asp Leu Val Asn Thr Pro Pro Met Ile Gly Thr Pro Val Tyr
180 185 190Met Ala Glu Val Ala Gln Lys Val Ala Lys Glu Asn His Leu Glu Ile
195 200 205His Val His Asp Glu Lys Phe Leu Glu Glu Lys Lys Met Asn Ala Phe
210 215 220Leu Ala Val Asn Lys Ala Ser Leu Ser Val Asn Pro Pro Arg Leu Ile225 230 235 240His Leu Val Tyr Lys Pro Lys Lys Ala Lys Lys Lys Ile Ala Leu Val
245 250 255Gly Lys Gly Leu Thr Tyr Asp Cys Gly Gly Leu Ser Leu Lys Pro Ala
260 265 270Asp Tyr Met Val Thr Met Lys Ala Asp Lys Gly Gly Gly Ser Ala Val
275 280 285Ile Gly Leu Leu Asn Ala Leu Ala Lys Leu Gly Val Glu Ala Glu Val
290 295 300His Gly Ile Ile Gly Ala Thr Glu Asn Met Ile Gly Pro Ala Ala Tyr305 310 315 320Lys Pro Asp Asp Ile Leu Ile Ser Lys Glu Gly Lys Ser Ile Glu Val
325 330 335Arg Asn Thr Asp Ala Glu Gly Arg Leu Val Leu Ala Asp Cys Leu Ser
340 345 350Tyr Ala Gln Asp Leu Asn Pro Asp Val Ile Val Asp Phe Ala Thr Leu
355 360 365Thr Gly Ala Cys Val Val Gly Leu Gly Glu Phe Thr Ser Ala Ile Met
370 375 380Gly His Asn Glu Glu Leu Lys Asn Leu Phe Glu Thr Ser Gly Leu Glu385 390 395 400Ser Gly Glu Leu Leu Ala Lys Leu Pro Phe Asn Arg His Leu Lys Lys
405 410 415Leu Ile Glu Ser Lys Ile Ala Asp Val Cys Asn Ile Ser Ser Ser Arg
420 425 430Tyr Gly Gly Ala Ile Thr Ala Gly Leu Phe Leu Asn Glu Phe Ile Arg
435 440 445Asp Glu Phe Lys Asp Lys Trp Leu His Ile Asp Ile Ala Gly Pro Ala
450 455 460Tyr Val Glu Lys Glu Trp Asp Val Asn Ser Phe Gly Ala Ser Gly Ala465 470 475 480Gly Val Arg Ala Cys Thr Ala Phe Val Glu Glu Leu Leu Lys Lys Ala
485 490 495
(2) Data in sequence 737:
(i) sequence characteristics:
(A) length: 560 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...492
(D) Other information:
(xi) Description of the sequence: sequence 737: GGCGAAATCG GGTTAATTTT AGCAGGGATT GCCAGCTATA CCGGTCAT ATG CAT TTA 57
Met His Leu
1GGG TTA GCC ATT TTA GTC GCA GGG ATT GGG GGC TTT GTG GGG GAT CAG 105Gly Leu Ala Ile Leu Val Ala Gly Ile Gly Gly Phe Val Gly Asp Gln
5 10 15ATC TAT TTT TAC ATC GGC CGC ACC AAT AAA GCT TAC ATC CAA AAA AAG 153Ile Tyr Phe Tyr Ile Gly Arg Thr Asn Lys Ala Tyr Ile Gln Lys Lys20 25 30 35CTA GAA AAA CAA CGCCGA AAA CTA GCC CTA GCC CAT TTA TTG TTG CAA 201Leu Glu Lys Gln Arg Arg Lys Leu Ala Leu Ala His Leu Leu Leu Gln
40 45 50AAA CAC GGC TGG TTT ATC ATT TTT ATC CAA CGC TAT ATG TAT GGC ATG 249Lys His Gly Trp Phe Ile Ile Phe Ile Gln Arg Tyr Met Tyr Gly Met
55 60 65CGC ACC ATC ATT CCC ATT AGC ATA GGT CTC ACG CGT TAT AGC GCT TTA 297Arg Thr Ile Ile Pro Ile Ser Ile Gly Leu Thr Arg Tyr Ser Ala Leu
70 75 80AAA TTC GCT ATC ATC AAT CTC ATT AGC GCG ATG GTG TGG GCG AGC ATT 345Lys Phe Ala Ile Ile Asn Leu Ile Ser Ala Met Val Trp Ala Ser Ile
85 90 95ACC ATT ATT CTA GCG TGG TAT TTA GGA GAA GAG TTA TTG CAT GCG TTA 393Thr Ile Ile Leu Ala Trp Tyr Leu Gly Glu Glu Leu Leu His Ala Leu100 105 110 115GGG TGG CTT AAA AAA CAC CCT TAT GCG CTA ATA TTA CTA TTA GTA TCT 441Gly Trp Leu Lys Lys His Pro Tyr Ala Leu Ile Leu Leu Leu Val Ser
120 125 130TTC TTG GCG TTA GTG CTG TGG TAT TTC CAA TAC TAT AGT AAG AAA AAC 489Phe Leu Ala Leu Val Leu Trp Tyr Phe Gln Tyr Tyr Ser Lys Lys Asn
135 140 145CGC TAGAGTGCAA TACAATTCTT GAAAGATATG AAATTAAAAA AGGAGACTTT ATGTTA 548ArgAAAATCAAAT TA 560
(2) Sequence 738 data:
(i) sequence characteristics:
(A) length: 148 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 738: met His Leu Gly Leu Ala Ile Leu Val Ala Gly Ile Gly Gly Phe Val 151015 Gly Asp Gln Ile Tyr Phe Tyr Ile Gly Arg Thr Asn Lys Ala Tyr Ile
20 25 30Gln Lys Lys Leu Glu Lys Gln Arg Arg Lys Leu Ala Leu Ala His Leu
35 40 45Leu Leu Gln Lys His Gly Trp Phe Ile Ile Phe Ile Gln Arg Tyr Met
50 55 60Tyr Gly Met Arg Thr Ile Ile Pro Ile Ser Ile Gly Leu Thr Arg Tyr65 70 75 80Ser Ala Leu Lys Phe Ala Ile Ile Asn Leu Ile Ser Ala Met Val Trp
85 90 95Ala Ser Ile Thr Ile Ile Leu Ala Trp Tyr Leu Gly Glu Glu Leu Leu
100 105 110His Ala Leu Gly Trp Leu Lys Lys His Pro Tyr Ala Leu Ile Leu Leu
115 120 125Leu Val Ser Phe Leu Ala Leu Val Leu Trp Tyr Phe Gln Tyr Tyr Ser
130 135 140Lys Lys Asn Arg145
(2) Sequence 739 data:
(i) sequence characteristics:
(A) length: 609bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 61...600
(D) Other information:
(xi) Description of the sequence: sequence 739: TAAAAACGCT ATAATAAATC AAAATTCTAC AACCAATCCG TTATATTAAA GGAAATCAAA 60ATG AAT GAA ACG CTC AAA GAA GAA CTT TTA CAA AGC ATC AGA GAA GTG 108Met Asn Glu Thr Leu Lys Glu Glu Leu Leu Gln Ser Ile Arg Glu Val 151015 AAA GAC TAC CCT AAA AAA GGG ATT TTA TTC AAA GAC ATT ACC ACG CTA 156Lys Asp Tyr Pro Lys Lys Gly Ile Leu Phe Lys Asp Ile Thr Thr Leu
20 25 30CTC AAC TAC CCT AAA CTC TTT AAC AAA CTC ATT GAC ACG CTC AAA AAA 204Leu Asn Tyr Pro Lys Leu Phe Asn Lys Leu Ile Asp Thr Leu Lys Lys
35 40 45CGC TAT CTC GCT CTC AAT ATA GAC TTT ATC GTG GGC ATT GAA GCG AGA 252Arg Tyr Leu Ala Leu Asn Ile Asp Phe Ile Val Gly Ile Glu Ala Arg
50 55 60GGG TTT ATT TTA GGC TCT GCT CTC GCT TAT GCG CTT GGG GTG GGT TTT 300Gly Phe Ile Leu Gly Ser Ala Leu Ala Tyr Ala Leu Gly Val Gly Phe65 70 75 80GTG CCT GTG AGG AAA AAG GGC AAA CTC CCC GCA CAC ACC CTA TCT CAA 348Val Pro Val Arg Lys Lys Gly Lys Leu Pro Ala His Thr Leu Ser Gln
85 90 95AGC TAC AGC CTA GAA TAC GGG AGC GAC AGC ATA GAA ATC CAC TCC GAC 396Ser Tyr Ser Leu Glu Tyr Gly Ser Asp Ser Ile Glu Ile His Ser Asp
100 105 110GCT TTT AGG GGA ATT AAG GGG GTA AGG GTG GTG TTG ATT GAT GAT TTA 444Ala Phe Arg Gly Ile Lys Gly Val Arg Val Val Leu Ile Asp Asp Leu
115 120 125TTA GCC ACT GGA GGC ACA GCT TTA GCG AGC CTT GAG CTT ATC AAA GCC 492Leu Ala Thr Gly Gly ThrAla Leu Ala Ser Leu Glu Leu Ile Lys Ala
130 135 140CTA CAA GCC GAA TGC ATA GAA GCA TGC TTT TTG ATA GGG TTA AAA GAA 540Leu Gln Ala Glu Cys Ile Glu Ala Cys Phe Leu Ile Gly Leu Lys Glu145 150 155 160TTA CCG GGT ATC CAA CTT TTA GAA GAA CGC GTG AAA ACC TTT TGT TTG 588Leu Pro Gly Ile Gln Leu Leu Glu Glu Arg Val Lys Thr Phe Cys Leu
165 170 175TTA GAG TTA GAA TAAGGGTGA 609Leu Glu Leu Glu
180
(2) Sequence 740 data:
(i) sequence characteristics:
(A) length: 180 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 740: met Asn Glu Thr Leu Lys Glu Glu Leu Leu Gln Ser Ile Arg Glu Val 151015 Lys Asp Tyr Pro Lys Lys Gly Ile Leu Phe Lys Asp Ile Thr Thr Leu
20 25 30Leu Asn Tyr Pro Lys Leu Phe Asn Lys Leu Ile Asp Thr Leu Lys Lys
35 40 45Arg Tyr Leu Ala Leu Asn Ile Asp Phe Ile Val Gly Ile Glu Ala Arg
50 55 60Gly Phe Ile Leu Gly Ser Ala Leu Ala Tyr Ala Leu Gly Val Gly Phe65 70 75 80Val Pro Val Arg Lys Lys Gly Lys Leu Pro Ala His Thr Leu Ser Gln
85 90 95Ser Tyr Ser Leu Glu Tyr Gly Ser Asp Ser Ile Glu Ile His Ser Asp
100 105 110Ala Phe Arg Gly Ile Lys Gly Val Arg Val Val Leu Ile Asp Asp Leu
115 120 125Leu Ala Thr Gly Gly Thr Ala Leu Ala Ser Leu Glu Leu Ile Lys Ala
130 135 140Leu Gln Ala Glu Cys Ile Glu Ala Cys Phe Leu Ile Gly Leu Lys Glu145 150 155 160Leu Pro Gly Ile Gln Leu Leu Glu Glu Arg Val Lys Thr Phe Cys Leu
165 170 175Leu Glu Leu Glu
180
(2) Sequence 741 data:
(i) sequence characteristics:
(A) length: 374 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 28...357
(D) Other information:
(xi) Description of the sequence: sequence 741: TTTCGCTAAA AAGGATATTT TAACAGA ATG TTT ACC CAA TGG TTT ATT CTC ACT 54
Met Phe Thr Gln Trp Phe Ile Leu Thr
1 5ATC GCT ATT GTT TTT ATC CTT TAT ATG GGT GTG CGC ACT TTC TTT TTT 102Ile Ala Ile Val Phe Ile Leu Tyr Met Gly Val Arg Thr Phe Phe Phe10 15 2025AAA ACC GTG GCT AAA CGG CAA GAA CGC ACC AAC GCA TCC ATG AAG CTC 150Lys Thr Val Ala Lys Arg Gln Glu Arg Thr Asn Ala Ser Met Lys Leu
30 35 40ACC TTA CAA GAA GCT GAA ATT TTG ATC CAA AAA CAC CAG TTG CAA CTC 198Thr Leu Gln Glu Ala Glu Ile Leu Ile Gln Lys His Gln Leu Gln Leu
45 50 55CAA AGG GCT TTG GGC AAT ATT GAT ATT CTC ACC CAA GAA ATG AGC TCG 246Gln Arg Ala Leu Gly Asn Ile Asp Ile Leu Thr Gln Glu Met Ser Ser
60 65 70TTA AAA ACA GAA CTA AAA GCC CTT AAA CAG CGC AAC TCT GAA TAC AAA 294Leu Lys Thr Glu Leu Lys Ala Leu Lys Gln Arg Asn Ser Glu Tyr Lys
75 80 85GGC GAA TCG GAT AAA TAT AAA AAT CGT ATT AAA GAA TTG GAG CAA AAA 342Gly Glu Ser Asp Lys Tyr Lys Asn Arg Ile Lys Glu Leu Glu Gln Lys90 95 100 105ATA GAA GCT CTC CTT TAAAAACGCT ATAATAA 374Ile Glu Ala Leu Leu
110
(2) Data of sequence 742:
(i) sequence characteristics:
(A) length: 110 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 742: met Phe Thr Gln Trp Phe Ile Leu Thr Ile Ala Ile Val Phe Ile Leu 151015 Tyr Met Gly Val Arg Thr Phe Phe Phe Lys Thr Val Ala Lys Arg Gln
20 25 30Glu Arg ThrAsn Ala Ser Met Lys Leu Thr Leu Gln Glu Ala Glu Ile
35 40 45Leu Ile Gln Lys His Gln Leu Gln Leu Gln Arg Ala Leu Gly Asn Ile
50 55 60Asp Ile Leu Thr Gln Glu Met Ser Ser Leu Lys Thr Glu Leu Lys Ala65 70 75 80Leu Lys Gln Arg Asn Ser Glu Tyr Lys Gly Glu Ser Asp Lys Tyr Lys
85 90 95Asn Arg Ile Lys Glu Leu Glu Gln Lys Ile Glu Ala Leu Leu
100 105 110
(2) Sequence 743 data:
(i) sequence characteristics:
(A) length: 778 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 78...728
(D) Other information:
(xi) Description of the sequence: sequence 743: AAAAAAGAAA ACGCAACGCA TTAAGGTTTT TTGTGCAATT TTTTGATTTC TCTTTAGAAA 60GTTTTATTAC CACCTTA ATG AAA ATC CTA GCC CTT TTA ATC GCT ATC ATA 110
Met Lys Ile Leu Ala Leu Leu Ile Ala Ile Ile
1 5 10GGG CAT GAG ATC ATG CAT GGC TTG AGC GCG TTT TTA TTT GGG GAT AGG 158Gly His Glu Ile Met His Gly Leu Ser Ala Phe Leu Phe Gly Asp Arg
1520 25AGC ACT AAA GAC GCT AGG CGT TTG AGT TTA AAC CCT ATC AGG CAT TTA 206Ser Thr Lys Asp Ala Arg Arg Leu Ser Leu Asn Pro Ile Arg His Leu
30 35 40GAC ATG ATG GGT TCG GTG CTT TTA CCG GCT TTA TTA CTC ATT TTT CAA 254Asp Met Met Gly Ser Val Leu Leu Pro Ala Leu Leu Leu Ile Phe Gln
45 50 55GCC CCT TTT TTG TTT GGG TGG GCC AAA CCC GTG CCT GTT GAT ATG CGC 302Ala Pro Phe Leu Phe Gly Trp Ala Lys Pro Val Pro Val Asp Met Arg60 65 70 75TAC ATT GTC TCT CAA AAA GGC TCT CTA GCA TGC GTA GTG GTG AGT TTA 350Tyr Ile Val Ser Gln Lys Gly Ser Leu Ala Cys Val Val Val Ser Leu
80 85 90GCC GGG GTG GCT TAT AAT TTC ACT CTG GCC GTT CTG CTC GCT TTC ATC 398Ala Gly Val Ala Tyr Asn Phe Thr Leu Ala Val Leu Leu Ala Phe Ile
95 100 105ACG CAT TGG AGC TTC CAA CAA CTA GGG ATC AAC GCT TTA AGC ATT GAT 446Thr His Trp Ser Phe Gln Gln Leu Gly Ile Asn Ala Leu Ser Ile Asp
110 115 120GAA TTG AAT CTT TAT CAG CTC GCT TTA GTA ACC TTT CTC ATT CAA GGC 494Glu Leu Asn Leu Tyr Gln Leu Ala Leu Val Thr Phe Leu Ile Gln Gly
125 130 135ATT CTT TAT AAT CTT GTC TTA GGC GTT TTC AAT AGC CTC CCT ATC CCG 542Ile Leu Tyr Asn Leu Val Leu Gly Val Phe Asn Ser Leu Pro Ile Pro140 145 150 155CCC TTA GAC GGC TCC AAA GCG TTA GGC TTT TTA GCG TTG CAT TTT AAA 590Pro Leu Asp Gly Ser Lys Ala Leu Gly Phe Leu Ala Leu His Phe Lys
160 165 170AGT GCG TTT TTA TTG GAA TGG TTT TCT AAA ATG GAA CGC TAC GGCTTG 638Ser Ala Phe Leu Leu Glu Trp Phe Ser Lys Met Glu Arg Tyr Gly Leu
175 180 185TTG GTA GTG TTT ATT TTT TTG TTT ATC CCC CCT TTA TCG GAG TTT TTT 686Leu Val Val Phe Ile Phe Leu Phe Ile Pro Pro Leu Ser Glu Phe Phe
190 195 200ATC CAT GCG CCC ACA AGA TTT TTA TTT TCT TTA CTC CTC TCT TAATCTTTT 737Ile His Ala Pro Thr Arg Phe Leu Phe Ser Leu Leu Leu Ser
205 210 215ATCAAGGAGA GTTTATGAAT AAGCTCTTAA AGTTTTCTCA A 778
(2) Sequential 744 data:
(i) sequence characteristics:
(A) length: 217 amino acid
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 744: met Lys Ile Leu Ala Leu Leu Ile Ala Ile Ile Gly His Glu Ile Met 151015 His Gly Leu Ser Ala Phe Leu Phe Gly Asp Arg Ser Thr Lys Asp Ala
20 25 30Arg Arg Leu Ser Leu Asn Pro Ile Arg His Leu Asp Met Met Gly Ser
35 40 45Val Leu Leu Pro Ala Leu Leu Leu Ile Phe Gln Ala Pro Phe Leu Phe
50 55 60Gly Trp Ala Lys Pro Val Pro Val Asp Met Arg Tyr Ile Val Ser Gln65 70 75 80Lys Gly Ser Leu Ala Cys Val Val Val Ser Leu Ala Gly Val Ala Tyr
85 90 95Asn Phe Thr Leu Ala Val LeuLeu Ala Phe Ile Thr His Trp Ser Phe
100 105 110Gln Gln Leu Gly Ile Asn Ala Leu Ser Ile Asp Glu Leu Asn Leu Tyr
115 120 125Gln Leu Ala Leu Val Thr Phe Leu Ile Gln Gly Ile Leu Tyr Asn Leu
130 135 140Val Leu Gly Val Phe Asn Ser Leu Pro Ile Pro Pro Leu Asp Gly Ser145 150 155 160Lys Ala Leu Gly Phe Leu Ala Leu His Phe Lys Ser Ala Phe Leu Leu
165 170 175Glu Trp Phe Ser Lys Met Glu Arg Tyr Gly Leu Leu Val Val Phe Ile
180 185 190Phe Leu Phe Ile Pro Pro Leu Ser Glu Phe Phe Ile His Ala Pro Thr
195 200 205Arg Phe Leu Phe Ser Leu Leu Leu Ser
210 215
(2) Sequence 745 data:
(i) sequence characteristics:
(A) length: 373 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...336
(D) Other information:
(xi) Description of the sequence: sequence 745: CATCAGATAT TATCCAAGCG CCTTTTAAAA TCTTGCGCCG TATTTTCACA CCTATTGACA 60TCATCGTGG ATG AAG TCA AAA AAA ACA TTG ATT CAA AAA GGA AGT AAA ATG 111
Met Lys Ser Lys Lys Thr Leu Ile Gln Lys Gly Ser Lys Met
1 5 10ACG CTC AAT GAA GCC ATT AAA GAC AAA GTT TAT GAA ATC GTA GAA ATC 159Thr Leu Asn Glu Ala Ile Lys Asp Lys Val Tyr Glu Ile Val Glu Ile15 20 25 30GCT AAC TGC GAT GAA GCC CTT AAA AAA CGC TTT CTC TCT TTT GGT ATC 207Ala Asn Cys Asp Glu Ala Leu Lys Lys Arg Phe Leu Ser Phe Gly Ile
35 40 45CAT GAA GGG GTT CAA TGC ATT CTT TTG CAT TAT TCC ATG AAA AAA GCC 255His Glu Gly Val Gln Cys Ile Leu Leu His Tyr Ser Met Lys Lys Ala
50 55 60ACG CTT TCG GTT AAA ATC AAC CGC ATT CAA GTG GCT TTA AGA TCC CAT 303Thr Leu Ser Val Lys Ile Asn Arg Ile Gln Val Ala Leu Arg Ser His
65 70 75GAA GCA CAA TAC CTT GTC ATC AAA GAA AGC GTG TGAAAATGGG TTTAAAACGC 356Glu Ala Gln Tyr Leu Val Ile Lys Glu Ser Val
80 85GCTAAACGCT ATAATAA 373
(2) Sequence 746 data:
(i) sequence characteristics:
(A) length: 89 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 746: met Lys Ser Lys Lys Thr Leu Ile Gln Lys Gly Ser Lys Met Thr Leu 151015 Asn Glu Ala Ile Lys Asp Lys Val Tyr Glu Ile Val Glu Ile Ala Asn
20 2530Cys Asp Glu Ala Leu Lys Lys Arg Phe Leu Ser Phe Gly Ile His Glu
35 40 45Gly Val Gln Cys Ile Leu Leu His Tyr Ser Met Lys Lys Ala Thr Leu
50 55 60Ser Val Lys Ile Asn Arg Ile Gln Val Ala Leu Arg Ser His Glu Ala65 70 75 80Gln Tyr Leu Val Ile Lys Glu Ser Val
85
(2) Sequence 747 data:
(i) sequence characteristics:
(A) length: 450bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 46...375
(D) Other information:
(xi) Description of the sequence: sequence 747: GAGCCAGTTA ATTCCATGGT TTCATAAGTG ATTTTTTGGG GCTGT ATG AGG AGC TGT 57
Met Arg Ser Cys
1TTG TTT TTG AAA ACT AAT TCG GTT TTA TCC ATT TTA ATG GGC GAT AAG 105Leu Phe Leu Lys Thr Asn Ser Val Leu Ser Ile Leu Met Gly Asp Lys 5 10 15 20CCA TCA TTA AAA ACG ACT GAA GGC TTC ATC AAA GTG GCT TTA ATT ACA 153Pro Ser Leu Lys Thr Thr Glu Gly Phe Ile Lys Val Ala Leu Ile Thr
25 30 35GAA TTT TTT AAA AGC GAT GGG ACAAAC TCG CTA GGA GTG AAA TTG GCT 201Glu Phe Phe Lys Ser Asp Gly Thr Asn Ser Leu Gly Val Lys Leu Ala
40 45 50TTG ATT GAA GCG TTA TCA ATC TTA AAG CTA GCG AAT TGG ATC TTA TCA 249Leu Ile Glu Ala Leu Ser Ile Leu Lys Leu Ala Asn Trp Ile Leu Ser
55 60 65AAA ATC CAT GTT TTT AAA TTT TTT TGC GAT TGG CGT TGG AAA AGA GGC 297Lys Ile His Val Phe Lys Phe Phe Cys Asp Trp Arg Trp Lys Arg Gly
70 75 80TTT AAA AAC GCC AGG CTT TTC ATT ACA GAA GTG TTA ATT TTT AAT TCT 345Phe Lys Asn Ala Arg Leu Phe Ile Thr Glu Val Leu Ile Phe Asn Ser85 90 95 100ATG GTT TTT AAA TCG GTT AGC CCT TGC AAA TAAATTGCAG CGCTGGGTTC GAT 398Met Val Phe Lys Ser Val Ser Pro Cys Lys
105 110TAAGGGCTTG ACAATCAAAT TAAACGCCAT TTTCCTAGCT TTGGGTGAAT AG 450
(2) Sequence 748 data:
(i) sequence characteristics:
(A) length: 110 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 748: met Arg Ser Cys Leu Phe Leu Lys Thr Asn Ser Val Leu Ser Ile Leu 151015 Met Gly Asp Lys Pro Ser Leu Lys Thr Thr Glu Gly Phe Ile Lys Val
20 25 30Ala Leu Ile Thr Glu Phe Phe Lys Ser Asp Gly Thr Asn Ser Leu Gly
35 40 45Val Lys Leu Ala Leu Ile Glu Ala Leu Ser Ile Leu Lys Leu Ala Asn
50 55 60Trp Ile Leu Ser Lys Ile His Val Phe Lys Phe Phe Cys Asp Trp Arg65 70 75 80Trp Lys Arg Gly Phe Lys Asn Ala Arg Leu Phe Ile Thr Glu Val Leu
85 90 95Ile Phe Asn Ser Met Val Phe Lys Ser Val Ser Pro Cys Lys
100 105 110
(2) Sequence 749 data:
(i) sequence characteristics:
(A) length: 450bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 56...394
(D) Other information:
(xi) Description of the sequence: sequence 749: GGCAAATTTT GATTGCTAGG GCTTTAAATG CAGCTTTTAG CACAAAGGAG AATGA ATG 58
Met
1GCT AAA ATG AGC GCT CCA GAT GGG GTT GCC GTT TGG GTG AAT GAA GAC 106Ala Lys Met Ser Ala Pro Asp Gly Val Ala Val Trp Val Asn Glu Asp
5 10 15AGG TGT AAG GGT TGT GAT ATT TGC GTA TCG GTA TGC CCT GCT GGG GTT 154Arg Cys Lys Gly Cys Asp Ile Cys Val Ser Val Cys Pro Ala Gly Val
20 2530CTT GGC ATG GGG ATT GAA AAA GAA AGG GTG CTT GGA AAA GTG GCC AAA 202Leu Gly Met Gly Ile Glu Lys Glu Arg Val Leu Gly Lys Val Ala Lys
35 40 45GTA GCC TAC CCA GAG AGC TGT ATC GGT TGC GTG CAA TGC GAG TTG CAC 250Val Ala Tyr Pro Glu Ser Cys Ile Gly Cys Val Gln Cys Glu Leu His50 55 60 65TGC CCG GAT TTT GCG ATT TAT GTG GCT GAC AGG AAG GAT TTC AAA TTC 298Cys Pro Asp Phe Ala Ile Tyr Val Ala Asp Arg Lys Asp Phe Lys Phe
70 75 80GCT AAA GTT TCT AAA GAA GCC CAA GAA AGA AGC GAA AAG GTT AAG GCC 346Ala Lys Val Ser Lys Glu Ala Gln Glu Arg Ser Glu Lys Val Lys Ala
85 90 95AAT AAA TAC ATG CTC TTA GAA GAG ACT ATT TTA GAA GGG AGA GAC AAA T 395Asn Lys Tyr Met Leu Leu Glu Glu Thr Ile Leu Glu Gly Arg Asp Lys
100 105 110AATGCGTGAG ATTATTTCTG ATGGGAATGA ATTAGTCGCT AAAGCGGCGA TTGAA 450
(2) Sequence 750 data:
(i) sequence characteristics:
(A) length: 113 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 750: met Ala Lys Met Ser Ala Pro Asp Gly Val Ala Val Trp Val Asn Glu 151015 Asp Arg Cys Lys Gly Cys Asp Ile Cys Val Ser Val Cys Pro Ala Gly
20 25 30Val Leu Gly Met Gly Ile Glu Lys Glu Arg Val Leu Gly Lys Val Ala
35 40 45Lys Val Ala Tyr Pro Glu Ser Cys Ile Gly Cys Val Gln Cys Glu Leu
50 55 60His Cys Pro Asp Phe Ala Ile Tyr Val Ala Asp Arg Lys Asp Phe Lys65 70 75 80Phe Ala Lys Val Ser Lys Glu Ala Gln Glu Arg Ser Glu Lys Val Lys
85 90 95Ala Asn Lys Tyr Met Leu Leu Glu Glu Thr Ile Leu Glu Gly Arg Asp
100 105 110Lys
(2) Sequence 751 data:
(i) sequence characteristics:
(A) length: 1350bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 127...1251
(D) Other information:
(xi) Description of the sequence: sequence 751: TGTGGCTGAC AGGAAGGATT TCAAATTCGC TAAAGTTTCT AAAGAAGCCC AAGAAAGAAG 60CGAAAAGGTT AAGGCCAATA AATACATGCT CTTAGAAGAG ACTATTTTAG AAGGGAGAGA 120CAAATA ATG CGT GAG ATT ATT TCT GAT GGG AAT GAA TTA GTC GCT AAA 168
Met Arg Glu Ile Ile Ser Asp Gly Asn Glu Leu Val Ala Lys
1 5 10GCG GCG ATT GAA GTG GGG TGT CGG TTT TTT GGG GGC TAT CCT ATC ACG 216Ala Ala Ile Glu Val Gly Cys Arg Phe Phe Gly Gly Tyr Pro Ile Thr15 20 25 30CCA AGT TCG GAT ATT ATG CAT GCG ATG AGC GTG GCT TTA CCC AAA TGC 264Pro Ser Ser Asp Ile Met His Ala Met Ser Val Ala Leu Pro Lys Cys
35 40 45GGC GGT CAT TTT ATC CAA ATG GAA GAT GAA ATC AGC GGG ATT AGC GTG 312Gly Gly His Phe Ile Gln Met Glu Asp Glu Ile Ser Gly Ile Ser Val
50 55 60TCT TTA GGA GCG AGC ATG AGC GGG ACG AAG TCT ATG ACA GCA AGC TCT 360Ser Leu Gly Ala Ser Met Ser Gly Thr Lys Ser Met Thr Ala Ser Ser
65 70 75GGG CCT GGT ATT TCA TTG AAA GTG GAG CAA ATC GGT TAT TCT TTC ATG 408Gly Pro Gly Ile Ser Leu Lys Val Glu Gln Ile Gly Tyr Ser Phe Met
80 85 90GCG GAA ATC CCT TTA GTG ATC GCT GAT GTG ATG CGT TCA GGC CCA TCA 456Ala Glu Ile Pro Leu Val Ile Ala Asp Val Met Arg Ser Gly Pro Ser95 100 105 110ACC GGA ATG CCC ACT CGT GTG GCT CAA GGC GAT GTG AAT TTC TTA AGA 504Thr Gly Met Pro Thr Arg Val Ala Gln Gly Asp Val Asn Phe Leu Arg
115 120 125CAC CCC ATA CAT GGG GAT TTT AAA GCC GTC GCG CTC GCT CCT GCG AAT 552His Pro Ile His Gly Asp Phe Lys Ala Val Ala Leu Ala Pro Ala Asn
130 135 140TTA GAA GAA GCT TAC ACC GAA ACC GTT CGC GCG TTC AAT TTG GCT GAA 600Leu Glu Glu Ala Tyr Thr Glu Thr Val Arg Ala Phe Asn Leu Ala Glu
145 150 155ATG CTC ATG ACT CCT GTA TTC TTG CTC ATG GAT GAA ACC GTG GGG CAT 648Met Leu Met Thr Pro Val Phe Leu Leu Met Asp Glu Thr Val Gly His
160 165 170ATG TAT GGC AAG GTG CAA ATC CCA GAT TTA GAA GAA GTG CAA AAG ATG 696MetTyr Gly Lys Val Gln Ile Pro Asp Leu Glu Glu Val Gln Lys Met175 180 185 190ACT ATT AAT CGT AAG GAA TTT CTG GGC GAT AAA AAA GAC TAC AAG CCT 744Thr Ile Asn Arg Lys Glu Phe Leu Gly Asp Lys Lys Asp Tyr Lys Pro
195 200 205TAT GGG GTC GCA CAA GAC GAG CCG GCT GTT TTG AAC CCT TTC TTT AAA 792Tyr Gly Val Ala Gln Asp Glu Pro Ala Val Leu Asn Pro Phe Phe Lys
210 215 220GGT TAT CGC TAC CAT GTT TCA GGC TTG CAC CAT GGG CCT ATT GGC TTT 840Gly Tyr Arg Tyr His Val Ser Gly Leu His His Gly Pro Ile Gly Phe
225 230 235CCT ACT GAA GAC GCT AAA ATT GGT GGG GAT TTG ATT GAC AGA TTA TTT 888Pro Thr Glu Asp Ala Lys Ile Gly Gly Asp Leu Ile Asp Arg Leu Phe
240 245 250AAT AAG ATT GAA TCC AAG CAA GAC ATT ATC AAC GAA AAT GAG GAA ATG 936Asn Lys Ile Glu Ser Lys Gln Asp Ile Ile Asn Glu Asn Glu Glu Met255 260 265 270GAT TTA GAG GGT GCT GAA ATC GTT GTT ATC GCT TAC GGT TCG GTT TCT 984Asp Leu Glu Gly Ala Glu Ile Val Val Ile Ala Tyr Gly Ser Val Ser
275 280 285TTG GCG GTT AAA GAG GCC TTG AAA GAT TAC CAT AAA GAA AGC AAG CAA 1032Leu Ala Val Lys Glu Ala Leu Lys Asp Tyr His Lys Glu Ser Lys Gln
290 295 300AAA GTC GGC TTT TTC AGG CCT AAA ACC TTA TGG CCA AGC CCG GCT AAA 1080Lys Val Gly Phe Phe Arg Pro Lys Thr Leu Trp Pro Ser Pro Ala Lys
305 310 315CGC TTG AAA GAA ATA GGG GAT AAA TAC GAA AAA ATC CTT GTG ATT GAA 1128Arg Leu Lys Glu Ile Gly Asp Lys Tyr Glu Lys Ile Leu Val Ile Glu
320325 330TTG AAT AAA GGG CAG TAT TTA GAA GAA ATT GAA AGG GCT ATG CAA AGA 1176Leu Asn Lys Gly Gln Tyr Leu Glu Glu Ile Glu Arg Ala Met Gln Arg335 340 345 350AAG GTG CAT TTC TTG GGG CAA GCC AAT GGG CGC ACG ATT TCG CCT AAA 1224Lys Val His Phe Leu Gly Gln Ala Asn Gly Arg Thr Ile Ser Pro Lys
355 360 365CAA ATC ATC GCA AAA TTG AAG GAG CTT TAAAATGGCG TTTAATTATG ATGAATA 1278Gln Ile Ile Ala Lys Leu Lys Glu Leu
370 375TTTGCGTGTG GATAAAATAC CCACTTTGTG GTGTTGGGGC TGTGGCGATG GCGTGATTTT 1338GAAATCCATT AT 1350
(2) Data of sequence 752:
(i) sequence characteristics:
(A) length: 375 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 752: met Arg Glu Ile Ile Ser Asp Gly Asn Glu Leu Val Ala Lys Ala Ala 151015 Ile Glu Val Gly Cys Arg Phe Phe Gly Gly Tyr Pro Ile Thr Pro Ser
20 25 30Ser Asp Ile Met His Ala Met Ser Val Ala Leu Pro Lys Cys Gly Gly
35 40 45His Phe Ile Gln Met Glu Asp Glu Ile Ser Gly Ile Ser Val Ser Leu
50 55 60Gly Ala Ser Met Ser Gly Thr Lys Ser Met Thr Ala Ser Ser Gly Pro65 70 75 80Gly Ile Ser Leu Lys Val Glu Gln Ile Gly Tyr Ser Phe Met AlaGlu
85 90 95Ile Pro Leu Val Ile Ala Asp Val Met Arg Ser Gly Pro Ser Thr Gly
100 105 110Met Pro Thr Arg Val Ala Gln Gly Asp Val Asn Phe Leu Arg His Pro
115 120 125Ile His Gly Asp Phe Lys Ala Val Ala Leu Ala Pro Ala Asn Leu Glu
130 135 140Glu Ala Tyr Thr Glu Thr Val Arg Ala Phe Asn Leu Ala Glu Met Leu145 150 155 160Met Thr Pro Val Phe Leu Leu Met Asp Glu Thr Val Gly His Met Tyr
165 170 175Gly Lys Val Gln Ile Pro Asp Leu Glu Glu Val Gln Lys Met Thr Ile
180 185 190Asn Arg Lys Glu Phe Leu Gly Asp Lys Lys Asp Tyr Lys Pro Tyr Gly
195 200 205Val Ala Gln Asp Glu Pro Ala Val Leu Asn Pro Phe Phe Lys Gly Tyr
210 215 220Arg Tyr His Val Ser Gly Leu His His Gly Pro Ile Gly Phe Pro Thr225 230 235 240Glu Asp Ala Lys Ile Gly Gly Asp Leu Ile Asp Arg Leu Phe Asn Lys
245 250 255Ile Glu Ser Lys Gln Asp Ile Ile Asn Glu Asn Glu Glu Met Asp Leu
260 265 270Glu Gly Ala Glu Ile Val Val Ile Ala Tyr Gly Ser Val Ser Leu Ala
275 280 285Val Lys Glu Ala Leu Lys Asp Tyr His Lys Glu Ser Lys Gln Lys Val
290 295 300Gly Phe Phe Arg Pro Lys Thr LeuTrp Pro Ser Pro Ala Lys Arg Leu305 310 315 320Lys Glu Ile Gly Asp Lys Tyr Glu Lys Ile Leu Val Ile Glu Leu Asn
325 330 335Lys Gly Gln Tyr Leu Glu Glu Ile Glu Arg Ala Met Gln Arg Lys Val
340 345 350His Phe Leu Gly Gln Ala Asn Gly Arg Thr Ile Ser Pro Lys Gln Ile
355 360 365Ile Ala Lys Leu Lys Glu Leu
370 375
(2) Sequence 753 data:
(i) sequence characteristics:
(A) length: 192 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 54...164
(D) Other information:
(xi) Description of the sequence: sequence 753: TATGATAAAA GCTCTCATAT AACCCGCTAC TAGCCATAAG CAACAGCAAG GCA ATG 56
Met
1TAT TTA GGC TTA AAC CCA AAA CGC ACC ACC AAA AGC GCC ACA GCC CCT 104Tyr Leu Gly Leu Asn Pro Lys Arg Thr Thr Lys Ser Ala Thr Ala Pro
5 10 15ATT AAA ATC ATG TTG ATG CGT TGC GCC CAG CAA AAA ATA CAA GGC GAA 152Ile Lys Ile Met Leu Met Arg Cys Ala Gln Gln Lys Ile Gln Gly Glu
20 25 30TCT TTC AAA ACA TAGCCAAAAT AACCTTAAAA AACGCTTT 192Ser Phe Lys Thr
35
(2) Sequence 754 data:
(i) sequence characteristics:
(A) length: 37 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 754: met Tyr Leu Gly Leu Asn Pro Lys Arg Thr Thr Lys Ser Ala Thr Ala 151015 Pro Ile Lys Ile Met Leu Met Arg Cys Ala Gln Gln Lys Ile Gln Gly
20 25 30Glu Ser Phe Lys Thr
35
(2) Sequence 755 data:
(i) sequence characteristics:
(A) length: 1080bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 30...1049
(D) Other information:
(xi) Description of the sequence: sequence 755: ACCATAATTA GACAAACCTT TAAGGATTT ATG ATG ATT TTC ATT GAT GCA TGT 53
Met Met Ile Phe Ile Asp Ala Cys
1 5TTT AGA AAG GAA ACG CCT TAC ACG CCC ATT TGG ATG ATG AGG CAA GCG 101Phe Arg Lys Glu Thr Pro Tyr Thr Pro Ile Trp Met Met Arg Gln Ala
10 15 20GGG CGT TAC CTT AGC GAA TAC CAA GAG AGC CGT AAA AAA GCG GGG AGT 149Gly Arg Tyr Leu Ser Glu Tyr Gln Glu Ser Arg Lys Lys Ala Gly Ser25 30 35 40TTC TTG GAA TTG TGT AAA AAT AGC GAT CTA GCC ACA GAA GTT ACC TTA 197Phe Leu Glu Leu Cys Lys Asn Ser Asp Leu Ala Thr Glu Val Thr Leu
45 50 55CAG CCG GTA GAG ATT TTA GGC GTG GAT GCG GCT ATT TTG TTT AGC GAT 245Gln Pro Val Glu Ile Leu Gly Val Asp Ala Ala Ile Leu Phe Ser Asp
60 65 70ATT TTA GTA GTG CCT TTG GAA ATG GGC TTG AAT TTG GAG TTT ATC CCC 293Ile Leu Val Val Pro Leu Glu Met Gly Leu Asn Leu Glu Phe Ile Pro
75 80 85AAA AAG GGG CCG CAT TTT TTA GAG ACG ATT ACG GAT TTA AAA AGC GTG 341Lys Lys Gly Pro His Phe Leu Glu Thr Ile Thr Asp Leu Lys Ser Val
90 95 100GAA AGC CTA AAA GTA GGG GCT TAT AAA CAA CTA AAC TAT GTC TAT GAT 389Glu Ser Leu Lys Val Gly Ala Tyr Lys Gln Leu Asn Tyr Val Tyr Asp105 110 115 120ACG ATT TCT CAA ACG CGC CAA AAG CTT TCT AGA GAG AAA GCG TTA ATC 437Thr Ile Ser Gln Thr Arg Gln Lys Leu Ser Arg Glu Lys Ala Leu Ile
125 130 135GGT TTT TGC GGA TCG CCT TGG ACT TTA GCG ACT TAC ATG ATA GAA GGC 485Gly Phe Cys Gly Ser Pro Trp Thr Leu Ala Thr Tyr Met Ile Glu Gly
140 145150GAG GGG AGC AAA TCG TAT GCC AAA AGC AAG AAA ATG CTT TAT AGC GAG 533Glu Gly Ser Lys Ser Tyr Ala Lys Ser Lys Lys Met Leu Tyr Ser Glu
155 160 165CCT GAA GTT TTA AAA GCG CTT TTA GAA AAA TTA AGC CTT GAA TTG ATA 581Pro Glu Val Leu Lys Ala Leu Leu Glu Lys Leu Ser Leu Glu Leu Ile
170 175 180GAG TAT TTG AGC CTT CAA ATC CAA GCA GGG GTC AAT GCA GTG ATG ATC 629Glu Tyr Leu Ser Leu Gln Ile Gln Ala Gly Val Asn Ala Val Met Ile185 190 195 200TTT GAC TCA TGG GCT AGC GCT TTA GAA AAA GAA GCG TAT TTG AAA TTC 677Phe Asp Ser Trp Ala Ser Ala Leu Glu Lys Glu Ala Tyr Leu Lys Phe
205 210 215AGT TGG GAT TAT TTG AAA AAA ATC TCT AAA GAG CTT AAA AAA CGC TAT 725Ser Trp Asp Tyr Leu Lys Lys Ile Ser Lys Glu Leu Lys Lys Arg Tyr
220 225 230GCG CAT ATC CCA GTT ATC CTT TTC CCT AAA GGG ATT GGC GCT TAT TTG 773Ala His Ile Pro Val Ile Leu Phe Pro Lys Gly Ile Gly Ala Tyr Leu
235 240 245GAT AGC ATA GAT GGG GAA TTT GAT GTG TTT GGC GTG GAT TGG GGC ACG 821Asp Ser Ile Asp Gly Glu Phe Asp Val Phe Gly Val Asp Trp Gly Thr
250 255 260CCT TTA ACT GCG GCA AAA AAG ATT TTA GGC GGT AAG TAT GTT TTG CAA 869Pro Leu Thr Ala Ala Lys Lys Ile Leu Gly Gly Lys Tyr Val Leu Gln265 270 275 280GGG AAT TTA GAA CCC ACC CGC CTT TAT GAT AAA AAC GCT TTA GAA GAA 917Gly Asn Leu Glu Pro Thr Arg Leu Tyr Asp Lys Asn Ala Leu Glu Glu
285 290 295GGG GTT GAA ACG ATT CTA AAA GTC ATG GGC AAT CAA GGG CAT ATT TTT965Gly Val Glu Thr Ile Leu Lys Val Met Gly Asn Gln Gly His Ile Phe
300 305 310AAT TTA GGG CAT GGG ATG TTG CCG GAT TTA CCC AGA GAA AAC GCC AAA 1013Asn Leu Gly His Gly Met Leu Pro Asp Leu Pro Arg Glu Asn Ala Lys
315 320 325TAT TTA GTG CAA TTA GTG CAT GCT AAA ACC AGA CGA TAGGGGGATT GATGAA 1065Tyr Leu Val Gln Leu Val His Ala Lys Thr Arg Arg
330 335 340TACTATCATA AGATA 1080
(2) Sequence 756 data:
(i) sequence characteristics:
(A) length: 340 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 756: met Met Ile Phe Ile Asp Ala Cys Phe Arg Lys Glu Thr Pro Tyr Thr 151015 Pro Ile Trp Met Met Arg Gln Ala Gly Arg Tyr Leu Ser Glu Tyr Gln
20 25 30Glu Ser Arg Lys Lys Ala Gly Ser Phe Leu Glu Leu Cys Lys Asn Ser
35 40 45Asp Leu Ala Thr Glu Val Thr Leu Gln Pro Val Glu Ile Leu Gly Val
50 55 60Asp Ala Ala Ile Leu Phe Ser Asp Ile Leu Val Val Pro Leu Glu Met65 70 75 80Gly Leu Asn Leu Glu Phe Ile Pro Lys Lys Gly Pro His Phe Leu Glu
85 90 95Thr Ile Thr Asp Leu Lys Ser Val Glu Ser Leu Lys Val Gly Ala Tyr
100 105 110Lys Gln Leu Asn Tyr Val Tyr Asp Thr Ile Ser Gln Thr Arg Gln Lys
115 120 125Leu Ser Arg Glu Lys Ala Leu Ile Gly Phe Cys Gly Ser Pro Trp Thr
130 135 140Leu Ala Thr Tyr Met Ile Glu Gly Glu Gly Ser Lys Ser Tyr Ala Lys145 150 155 160Ser Lys Lys Met Leu Tyr Ser Glu Pro Glu Val Leu Lys Ala Leu Leu
165 170 175Glu Lys Leu Ser Leu Glu Leu Ile Glu Tyr Leu Ser Leu Gln Ile Gln
180 185 190Ala Gly Val Asn Ala Val Met Ile Phe Asp Ser Trp Ala Ser Ala Leu
195 200 205Glu Lys Glu Ala Tyr Leu Lys Phe Ser Trp Asp Tyr Leu Lys Lys Ile
210 215 220Ser Lys Glu Leu Lys Lys Arg Tyr Ala His Ile Pro Val Ile Leu Phe225 230 235 240Pro Lys Gly Ile Gly Ala Tyr Leu Asp Ser Ile Asp Gly Glu Phe Asp
245 250 255Val Phe Gly Val Asp Trp Gly Thr Pro Leu Thr Ala Ala Lys Lys Ile
260 265 270Leu Gly Gly Lys Tyr Val Leu Gln Gly Asn Leu Glu Pro Thr Arg Leu
275 280 285Tyr Asp Lys Asn Ala Leu Glu Glu Gly Val Glu Thr Ile Leu Lys Val
290 295 300Met Gly Asn Gln Gly His Ile Phe Asn Leu Gly His Gly Met Leu Pro305 310 315 320Asp Leu Pro Arg Glu Asn Ala Lys Tyr Leu Val Gln Leu Val HisAla
325 330 335Lys Thr Arg Arg
340
(2) Sequence 757 data:
(i) sequence characteristics:
(A) length: 766 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...732
(D) Other information:
(xi) Description of the sequence: sequence 757: TAGACGACTA TGTGCATTAA GGGAATGAAA ATG ATA CGA AAA ATT TTA ATA GGA 54
Met Ile Arg Lys Ile Leu Ile Gly
1 5CTT TTT TTG AGT TTT TTG AGC ATG GAA GCT GGC GAA AAA GTG TAT GCG 102Leu Phe Leu Ser Phe Leu Ser Met Glu Ala Gly Glu Lys Val Tyr Ala
10 15 20ATT TTC AAT GTG AAA GCG ACA CAA GAT TCC AAA CTC ACC TTA GAC AGC 150Ile Phe Asn Val Lys Ala Thr Gln Asp Ser Lys Leu Thr Leu Asp Ser25 30 35 40ACA GGA ATT GTG GAT AGC ATT AAG GTT ACT GAG GGG AGC GTG GTC AAA 198Thr Gly Ile Val Asp Ser Ile Lys Val Thr Glu Gly Ser Val Val Lys
45 50 55AAG GGC GAT GTT TTG TTG CTT TTA TAT AAT CAA GAC AAA CAG GCT CAA 246Lys Gly Asp Val Leu Leu Leu Leu Tyr Asn Gln Asp Lys Gln Ala Gln
60 65 70AGC GAT TCC ACC GAA CAA CAA CTC ATT TTC GCT AAA AAG CAA TAC CAA 294Ser Asp Ser Thr Glu Gln Gln Leu Ile Phe Ala Lys Lys Gln Tyr Gln
75 80 85CGA TAC AGC AAA ATT GGG GGC GCT GTG GAT AAA AAC ACT CTA GAG GGT 342Arg Tyr Ser Lys Ile Gly Gly Ala Val Asp Lys Asn Thr Leu Glu Gly
90 95 100TAT GAG TTC ACT TAC AGG CGC TTG GAG TCT GAT TAC GCT TAT TCT ATT 390Tyr Glu Phe Thr Tyr Arg Arg Leu Glu Ser Asp Tyr Ala Tyr Ser Ile105 110 115 120GCG GTA TTG AAT AAA ACC ATT TTA AGA GCC CCT TTT GAT GGC GTG ATA 438Ala Val Leu Asn Lys Thr Ile Leu Arg Ala Pro Phe Asp Gly Val Ile
125 130 135GCG AGT AAA AAC ATT CAA GTG GGC GAA GGG GTG AGC GCG AAT AAC ACG 486Ala Ser Lys Asn Ile Gln Val Gly Glu Gly Val Ser Ala Asn Asn Thr
140 145 150GTG TTA TTG AGA TTA GTC AGC CAT GCT AGG AAA TTA GTT ATT GAA TTT 534Val Leu Leu Arg Leu Val Ser His Ala Arg Lys Leu Val Ile Glu Phe
155 160 165GAT TCT AAA TAT ATT AAT GCG GTC AAA GTA GGG GAC ACT TAC ACC TAT 582Asp Ser Lys Tyr Ile Asn Ala Val Lys Val Gly Asp Thr Tyr Thr Tyr
170 175 180TCT ATA GAC GGG GAT TCT AAT CAG CAT GAA GCT AAA ATC ACT AAG ATT 630Ser Ile Asp Gly Asp Ser Asn Gln His Glu Ala Lys Ile Thr Lys Ile185 190 195 200TAC CCC ACG GTT GAT GAA AAC ACC AGG AAA GTG AGC GCT GAA GCC CTT 678Tyr Pro Thr Val Asp Glu Asn Thr Arg Lys Val Ser Ala Glu Ala Leu
205 210 215TTA TCT AAG CCT ATG GCA GTG GGGCTT TTT GGC GAT GGG TTT ATC CAA 726Leu Ser Lys Pro Met Ala Val Gly Leu Phe Gly Asp Gly Phe Ile Gln
220 225 230ACG AAA TAATAGGATA TTTTGATGTA TAAAACAGCG ATTA 766Thr Lys
(2) Sequence 758 data:
(i) sequence characteristics:
(A) length: 234 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 758: met Ile Arg Lys Ile Leu Ile Gly Leu Phe Leu Ser Phe Leu Ser Met 151015 Glu Ala Gly Glu Lys Val Tyr Ala Ile Phe Asn Val Lys Ala Thr Gln
20 25 30Asp Ser Lys Leu Thr Leu Asp Ser Thr Gly Ile Val Asp Ser Ile Lys
35 40 45Val Thr Glu Gly Ser Val Val Lys Lys Gly Asp Val Leu Leu Leu Leu
50 55 60Tyr Asn Gln Asp Lys Gln Ala Gln Ser Asp Ser Thr Glu Gln Gln Leu65 70 75 80Ile Phe Ala Lys Lys Gln Tyr Gln Arg Tyr Ser Lys Ile Gly Gly Ala
85 90 95Val Asp Lys Asn Thr Leu Glu Gly Tyr Glu Phe Thr Tyr Arg Arg Leu
100 105 110Glu Ser Asp Tyr Ala Tyr Ser Ile Ala Val Leu Ash Lys Thr Ile Leu
115 120 125Arg Ala Pro Phe Asp Gly Val Ile Ala Ser Lys Asn Ile Gln Val Gly
130135 140Glu Gly Val Ser Ala Asn Asn Thr Val Leu Leu Arg Leu Val Ser His145 150 155 160Ala Arg Lys Leu Val Ile Glu Phe Asp Ser Lys Tyr Ile Asn Ala Val
165 170 175Lys Val Gly Asp Thr Tyr Thr Tyr Ser Ile Asp Gly Asp Ser Asn Gln
180 185 190His Glu Ala Lys Ile Thr Lys Ile Tyr Pro Thr Val Asp Glu Asn Thr
195 200 205Arg Lys Val Ser Ala Glu Ala Leu Leu Ser Lys Pro Met Ala Val Gly
210 215 220Leu Phe Gly Asp Gly Phe Ile Gln Thr Lys225 230
(2) Sequence 759 data:
(i) sequence characteristics:
(A) length: 630bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 62...544
(D) Other information:
(xi) Description of the sequence: sequence 759: ACGCCAAAGA GAGCAACGGG GAGTTTTTAG TCGCTTTAGC GNAGCGNTTG TGCTGATTTA 60T ATG ATT TTA GCG GCG TTG TAT GAG TCC ATT TTA GAG CCT TTT ATC ATC 109Met Ile Leu Ala Ala Leu Tyr Glu Ser Ile Leu Glu Pro Phe Ile Ile 151015 ATG GTT ACC ATG CCT TTA AGT TTT TCA GGG GCG TTT TTT GCT CTA GGT 157Met Val Thr Met Pro Leu Ser Phe Ser Gly Ala Phe Phe Ala Leu Gly
20 25 30TTA GTC CAT CAG CCT TTG AGC ATG TTC TCT ATG ATA GGC TTG ATT TTG 205Leu Val His Gln Pro Leu Ser Met Phe Ser Met Ile Gly Leu Ile Leu
35 40 45CTC ATT GGT ATG GTG GGT AAA AAC GCC ACG CTT TTA ATT GAT GTG GCG 253Leu Ile Gly Met Val Gly Lys Asn Ala Thr Leu Leu Ile Asp Val Ala
50 55 60AAT GAA GAG CGT AAA AAA GGT TTG AAT ATC CAA GAG GCC ATT TTA TTT 301Asn Glu Glu Arg Lys Lys Gly Leu Asn Ile Gln Glu Ala Ile Leu Phe65 70 75 80GCC GGC AAA ACC CGT CTA AGA CCG ATT TTA ATG ACG ACC ATT GCG ATG 349Ala Gly Lys Thr Arg Leu Arg Pro Ile Leu Met Thr Thr Ile Ala Met
85 90 95GTT TGC GGG ATG CTG CCT TTA GCG TTG GCG AGT GGG GAT GGA GCG GCG 397Val Cys Gly Met Leu Pro Leu Ala Leu Ala Ser Gly Asp Gly Ala Ala
100 105 110ATG AAA TCC CCT ATA GGG ATT GCG ATG AGT GGG GGC TTG ATG ATT TCT 445Met Lys Ser Pro Ile Gly Ile Ala Met Ser Gly Gly Leu Met Ile Ser
115 120 125ATG GTG TTA AGC TTA CTC ATT GTG CCG GTG TTT TAT CGT TTG CTC GCT 493Met Val Leu Ser Leu Leu Ile Val Pro Val Phe Tyr Arg Leu Leu Ala
130 135 140CCC ATA GAC GAC AAA ATC AAG CGG TTT TAT CAA AAC CAA AAA ACT TTA 541Pro Ile Asp Asp Lys Ile Lys Arg Phe Tyr Gln Asn Gln Lys Thr Leu145 150 155 160GAA TGAAAAAAAT TGCTTTCATT TTGGCTTTAT GGGTGGGCTT GTTAGGGGCG TTTGAG 600GluCCTAAAAAAA GTCATATTTA TTTTGGGGCT 630
(2) Sequence 760 data:
(i) sequence characteristics:
(A) length: 161 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 760: met Ile Leu Ala Ala Leu Tyr Glu Ser Ile Leu Glu Pro Phe Ile Ile 151015 Met Val Thr Met Pro Leu Ser Phe Ser Gly Ala Phe Phe Ala Leu Gly
20 25 30Leu Val His Gln Pro Leu Ser Met Phe Ser Met Ile Gly Leu Ile Leu
35 40 45Leu Ile Gly Met Val Gly Lys Asn Ala Thr Leu Leu Ile Asp Val Ala
50 55 60Asn Glu Gln Arg Lys Lys Gly Leu Asn Ile Gln Glu Ala Ile Leu Phe65 70 75 80Ala Gly Lys Thr Arg Leu Arg Pro Ile Leu Met Thr Thr Ile Ala Met
85 90 95Val Cys Gly Met Leu Pro Leu Ala Leu Ala Ser Gly Asp Gly Ala Ala
100 105 110Met Lys Ser Pro Ile Gly Ile Ala Met Ser Gly Gly Leu Met Ile Ser
115 120 125Met Val Leu Ser Leu Leu Ile Val Pro Val Phe Tyr Arg Leu Leu Ala
130 135 140Pro Ile Asp Asp Lys Ile Lys Arg Phe Tyr Gln Asn Gln Lys Thr Leu145 150 155 160Glu
(2) Sequence 761 data:
(i) sequence characteristics:
(A) length: 1007 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...945
(D) Other information:
(xi) Description of the sequence: sequence 761: TAAAAGGTTT TTACAAAC ATG ATA AAA AGC CAA AAA GAA TAT TTA GAA AGA 51
Met Ile Lys Ser Gln Lys Glu Tyr Leu Glu Arg
1 5 10ATT GCA TAT TTA AAC ACC CTA TCG CAC CAT TAT TAC AAC CTT GAT GAA 99Ile Ala Tyr Leu Asn Thr Leu Ser His His Tyr Tyr Asn Leu Asp Glu
15 20 25CCC ATC GTA AGC GAT GCG ATC TAT GAT GAA CTT TAC CAA GAA TTG AAA 147Pro Ile Val Ser Asp Ala Ile Tyr Asp Glu Leu Tyr Gln Glu Leu Lys
30 35 40GCT TAT GAA GAA AAA AAC CCT AAT GGC ATT CAA GCT AAT TCC CCT ACC 195Ala Tyr Glu Glu Lys Asn Pro Asn Gly Ile Gln Ala Asn Ser Pro Thr
45 50 55CAA AAA GTG GGG GCT ACT ACC ACC AAT TCG TTC AAT AAA AAC CCC CAT 243Gln Lys Val Gly Ala Thr Thr Thr Asn Ser Phe Asn Lys Asn Pro His60 65 70 75TTA ATG CGG ATG TGG AGC TTA GAT GAT GTG TTC AAT CAA AGC GAA TTG 291Leu Met Arg Met Trp Ser Leu Asp Asp Val Phe Asn Gln Ser Glu Leu
80 85 90CAA GCG TGG TTG CAA CGC ATT TTA AAA GCC TAT CCT AGT GCT TCG TTC 339Gln Ala Trp Leu Gln Arg Ile Leu Lys Ala Tyr Pro Ser Ala Ser Phe
95 100 105GTG TGT TCG CCC AAA CTT GAT GGG GTT TCG CTC AAT CTT TTG TAT CAA 387Val Cys Ser Pro Lys Leu Asp Gly Val Ser Leu Asn Leu Leu Tyr Gln
110 115 120CAT GGC AAG CTA GTG AAG GCG ACC ACT AGG GGC AAC GGC TTA GAA GGA 435His Gly Lys Leu Val Lys Ala Thr Thr Arg Gly Asn Gly Leu Glu Gly
125 130 135GAA TTA GTT AGC GCA AAC GCT AAA CAC ATC GCT AAT ATC CCC CAC GCT 483Glu Leu Val Ser Ala Asn Ala Lys His Ile Ala Asn Ile Pro His Ala140 145 150 155ATC GCT TAT AAT GGA GAA ATA GAA ATC AGG GGC GAA GTG ATC ATT TCT 531Ile Ala Tyr Asn Gly Glu Ile Glu Ile Arg Gly Glu Val Ile Ile Ser
160 165 170AAA AAG GAT TTT GAC GCT TTG AAT CAA GAG CGC TTA AAC GCT AAT GAA 579Lys Lys Asp Phe Asp Ala Leu Asn Gln Glu Arg Leu Asn Ala Asn Glu
175 180 185CCC CTA TTC GCT AAC CCC AGA AAC GCC GCA TCA GGG AGT TTG AGG CAA 627Pro Leu Phe Ala Asn Pro Arg Asn Ala Ala Ser Gly Ser Leu Arg Gln
190 195 200CTT GAT AGC GAA ATC ACT AAA AAG CGT AAA TTG CAA TTC ATT CCT TGG 675Leu Asp Ser Glu Ile Thr Lys Lys Arg Lys Leu Gln Phe Ile Pro Trp
205 210 215GGC GTG GGC AAG CAT TCT TTA AAT TTT TTA AGC TTT AAG GAG TGT TTG 723Gly Val Gly Lys His Ser Leu Asn Phe Leu Ser Phe Lys Glu Cys Leu220 225 230 235GAT TTT ATC GTC TCG TTA GGT TTT AGC GCC ATT CAA TAC TTA AGC CTA 771Asp Phe Ile Val Ser Leu Gly Phe Ser Ala Ile Gln Tyr Leu Ser Leu
240 245 250AAC AAA AAC CAC CAA GAA ATA GAA GAC AAT TAC CAC ACC CTA ATT AGA 819Asn Lys Asn His Gln Glu Ile Glu Asp Asn Tyr His Thr Leu Ile Arg
255 260 265GAA AGG GAG GGC TTT TTT GCC CTT TTA GAC GGC ATG GTG ATC GTT GTG 867Glu Arg Glu Gly Phe Phe Ala Leu Leu Asp Gly Met Val Ile Val Val
270 275 280AAT GAA TTA AAT ATT CAA AAG GAG CTA GGC TAC ACG CAA AAA TCC CCT 915Asn Glu Leu Asn Ile Gln Lys Glu Leu Gly Tyr Thr Gln Lys Ser Pro
285 290 295AAA TNG CTT GCG CTT ATA AAT TCC CGG CTT TAGAAAAACA CACCAAAATT GTA 968Lys Xaa Leu Ala Leu Ile Asn Ser Arg Leu300 305GGAGTCATTA ACCAAGTGGG GCGCASSGGG CGATCACAC 1007
(2) Sequence 762 data:
(i) sequence characteristics:
(A) length: 309 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 762: met Ile Lys Ser Gln Lys Glu Tyr Leu Glu Arg Ile Ala Tyr Leu Asn 151015 Thr Leu Ser His His Tyr Tyr Asn Leu Asp Glu Pro Ile Val Ser Asp
20 25 30Ala Ile Tyr Asp Glu Leu Tyr Gln Glu Leu Lys Ala Tyr Glu Glu Lys
35 40 45Asn Pro Asn Gly Ile Gln Ala Asn Ser Pro Thr Gln Lys Val Gly Ala
50 55 60Thr Thr Thr Asn Ser Phe Asn Lys Asn Pro His Leu Met Arg Met Trp65 70 75 80Ser Leu Asp Asp Val Phe Asn Gln Ser Glu Leu Gln Ala Trp Leu Gln
85 90 95Arg Ile Leu Lys Ala Tyr Pro Ser Ala Ser Phe Val Cys Ser Pro Lys
100 105 110Leu Asp Gly Val Ser Leu Asn Leu Leu Tyr Gln His Gly Lys Leu Val
115 120 125Lys Ala Thr Thr Arg Gly Asn Gly Leu Glu Gly Glu Leu Val Ser Ala
130 135 140Asn Ala Lys His Ile Ala Asn Ile Pro His Ala Ile Ala Tyr Asn Gly145 150 155 160Glu Ile Glu Ile Arg Gly Glu Val Ile Ile Ser Lys Lys Asp Phe Asp
165 170 175Ala Leu Asn Gln Glu Arg Leu Asn Ala Asn Glu Pro Leu Phe Ala Asn
180 185 190Pro Arg Asn Ala Ala Ser Gly Ser Leu Arg Gln Leu Asp Ser Glu Ile
195 200 205Thr Lys Lys Arg Lys Leu Gln Phe Ile Pro Trp Gly Val Gly Lys His
210 215 220Ser Leu Asn Phe Leu Ser Phe Lys Glu Cys Leu Asp Phe Ile Val Ser225 230 235 240Leu Gly Phe Ser Ala Ile Gln Tyr Leu Ser Leu Asn Lys Asn His Gln
245 250 255Glu Ile Glu Asp Asn Tyr His Thr Leu Ile Arg Glu Arg Glu Gly Phe
260 265 270Phe Ala Leu Leu Asp Gly Met Val Ile Val Val Asn Glu Leu Asn Ile
275 280 285Gln Lys Glu Leu Gly Tyr Thr Gln Lys Ser Pro Lys Xaa Leu Ala Leu
290295 300Ile Asn Ser Arg Leu305
(2) Sequence 763 data:
(i) sequence characteristics:
(A) length: 937 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 44...880
(D) Other information:
(xi) Description of the sequence: sequence 763: GTGCTTTAGA TTAGATGCAG AAAAAGACGC CCAACTTTAT GGC ATG AAT ATT TTT 55
Met Asn Ile Phe
1AAG ATC CGA GAA ATT ATC CAT TAT GAC GGG GAG GTT ACA GAG ATT CTT 103Lys Ile Arg Glu Ile Ile His Tyr Asp Gly Glu Val Thr Glu Ile Leu 5 10 15 20GGG GGG AGC GAT GGC GTG ATG CTC GGG TTT CTT AGC GTT AGG GGC GAG 151Gly Gly Ser Asp Gly Val Met Leu Gly Phe Leu Ser Val Arg Gly Glu
25 30 35TCT ATC CCT TTA GTG GAT GTG AAA AGG TGG TTG CAT TAT AAC GCT AAT 199Ser Ile Pro Leu Val Asp Val Lys Arg Trp Leu His Tyr Asn Ala Asn
40 45 50GAT CCG AGC CGT GAT CTA AAA GAA TGC AGC GTT AAA GAT GAC CAT AAT 247Asp Pro Ser Arg Asp Leu Lys Glu Cys Ser Val Lys Asp Asp His Asn
55 60 65TTG GTG ATT GTG TGC CAT TTT TCT AAC CAT TCC ATC GCT CTA AAG GTT295Leu Val Ile Val Cys His Phe Ser Asn His Ser Ile Ala Leu Lys Val
70 75 80TTA AAA ATT GAA AGG ATC ATC CAT AAA AAT TGG ACT GAG ATT AGC GCT 343Leu Lys Ile Glu Arg Ile Ile His Lys Asn Trp Thr Glu Ile Ser Ala85 90 95 100GGG GAC AAA CAA GGC ATT AAT GAA GAG GGT AAG CTT AGC GCT ATC ACT 391Gly Asp Lys Gln Gly Ile Asn Glu Glu Gly Lys Leu Ser Ala Ile Thr
105 110 115CGT TTT GAT GAA GAA CGA GTG GTG CAG ATC TTA GAT GTG GAA AAA ATG 439Arg Phe Asp Glu Glu Arg Val Val Gln Ile Leu Asp Val Glu Lys Met
120 125 130ATT AGC GAT GTT TTC CCT AGC TTG AAA GAT TTA GAC GAT TTG ACT TTG 487Ile Ser Asp Val Phe Pro Ser Leu Lys Asp Leu Asp Asp Leu Thr Leu
135 140 145CGT TGC ATA GAA GCC ATT CAA AGC CAA AAA CTC ATT TTA ATC GCT GAA 535Arg Cys Ile Glu Ala Ile Gln Ser Gln Lys Leu Ile Leu Ile Ala Glu
150 155 160GAC TCC CTA AGC GCT CTT AAA ACC TTA GAA AAG ATC GTT CAA ACT TTA 583Asp Ser Leu Ser Ala Leu Lys Thr Leu Glu Lys Ile Val Gln Thr Leu165 170 175 180GAA TTG CGT TAT TTA GCT TTT CCA AAC GGG AGG GAA TTG TTG GAT TAT 631Glu Leu Arg Tyr Leu Ala Phe Pro Asn Gly Arg Glu Leu Leu Asp Tyr
185 190 195TTG TAT GAA AAA GAA CAT TAC CAA CAA GTT GGC GTG GTC ATT ACG GAT 679Leu Tyr Glu Lys Glu His Tyr Gln Gln Val Gly Val Val Ile Thr Asp
200 205 210TTA GAA ATG CCT AAC ATT TCA GGG TTT GAA GTG TTA AAA ACC ATT AAA 727Leu Glu Met Pro Asn Ile Ser Gly Phe Glu Val Leu Lys Thr Ile Lys
215 220 225GCT GAT CAT AGA ACT GAG CAT CTT CCT GTG ATT ATC AAT TCG TCC ATG 775Ala Asp His Arg Thr Glu His Leu Pro Val Ile Ile Asn Ser Ser Met
230 235 240AGC AGC GAT TCT AAC CGC CAG TTA GCC CAA TCT TTA GAA GCG GAT GGT 823Ser Ser Asp Ser Asn Arg Gln Leu Ala Gln Ser Leu Glu Ala Asp Gly245 250 255 260TTT GTG GTA AAA TCT AAC ATT CTT GAA ATC CAT GAA ATG CTT AAA AAA 871Phe Val Val Lys Ser Asn Ile Leu Glu Ile His Glu Met Leu Lys Lys
265 270 275ACG CTT TCA TAAATTTAAT TTTTGTTTTA ATTTAAAGGG ATAAAACATG CGAAGTCAT 929Thr Leu SerTTTTGCAC 937
(2) Sequence 764 data:
(i) sequence characteristics:
(A) length: 279 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 764: met Asn Ile Phe Lys Ile Arg Glu Ile Ile His Tyr Asp Gly Glu Val 151015 Thr Glu Ile Leu Gly Gly Ser Asp Gly Val Met Leu Gly Phe Leu Ser
20 25 30Val Arg Gly Glu Ser Ile Pro Leu Val Asp Val Lys Arg Trp Leu His
35 40 45Tyr Asn Ala Asn Asp Pro Ser Arg Asp Leu Lys Glu Cys Ser Val Lys
50 55 60Asp Asp His Asn Leu Val Ile Val Cys His Phe Ser Asn His Ser Ile65 70 75 80AlaLeu Lys Val Leu Lys Ile Glu Arg Ile Ile His Lys Asn Trp Thr
85 90 95Glu Ile Ser Ala Gly Asp Lys Gln Gly Ile Asn Glu Glu Gly Lys Leu
100 105 110Ser Ala Ile Thr Arg Phe Asp Glu Glu Arg ValVal Gln Ile Leu Asp
115 120 125Val Glu Lys Met Ile Ser Asp Val Phe Pro Ser Leu Lys Asp Leu Asp
130 135 140Asp Leu Thr Leu Arg Cys Ile Glu Ala Ile Gln Ser Gln Lys Leu Ile145 150 155 160Leu Ile Ala Glu Asp Ser Leu Ser Ala Leu Lys Thr Leu Glu Lys Ile
165 170 175Val Gln Thr Leu Glu Leu Arg Tyr Leu Ala Phe Pro Asn Gly Arg Glu
180 185 190Leu Leu Asp Tyr Leu Tyr Glu Lys Glu His Tyr Gln Gln ValGly Val
195 200 205Val Ile Thr Asp Leu Glu Met Pro Asn Ile Ser Gly Phe Glu Val Leu
210 215 220Lys Thr Ile Lys Ala Asp His Arg Thr Glu His Leu Pro Val Ile Ile225 230 235 240Asn Ser Ser Met Ser Ser Asp Ser Asn Arg Gln Leu Ala Gln Ser Leu
245 250 255Glu Ala Asp Gly Phe Val Val Lys Ser Asn Ile Leu Glu Ile His Glu
260 265 270Met Leu Lys Lys Thr Leu Ser
275
(2) Data of sequence 765:
(i) sequence characteristics:
(A) length: 630bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 21...593
(D) Other information:
(xi) Description of the sequence: sequence 765: ATAATTTAAA AGGATACGAT ATG AAA CAA CTA TTT TTG ATC ATT GGA GCC 50
Met Lys Gln Leu Phe Leu Ile Ile Gly Ala
1 5 10CCA GGG AGT GGT AAA ACC ACT GAT GCA GAG CTT ATC GCT AAA AAT AAC 98Pro Gly Ser Gly Lys Thr Thr Asp Ala Glu Leu Ile Ala Lys Asn Asn
15 20 25AGC GAA ACA ATC GCT CAT TTT TCT ACC GGG GAT TTA CTC AGG GCT GAG 146Ser Glu Thr Ile Ala His Phe Ser Thr Gly Asp Leu Leu Arg Ala Glu
30 35 40AGC GCT AAA AAG ACC GAG CGA GGC TTA TTG ATT GAA AAA TTC ACT TCT 194Ser Ala Lys Lys Thr Glu Arg Gly Leu Leu Ile Glu Lys Phe Thr Ser
45 50 55CAA GGC GAA TTA GTG CCT TTA GAA ATT GTG GTA GAA ACG ATC CTT TCA 242Gln Gly Glu Leu Val Pro Leu Glu Ile Val Val Glu Thr Ile Leu Ser
60 65 70GCG ATT AAA AGC TCT GGT AAA GGG ATC ATT TTA ATT GAT GGT TAT CCT 290Ala Ile Lys Ser Ser Gly Lys Gly Ile Ile Leu Ile Asp Gly Tyr Pro75 80 85 90AGG AGC GTG GAA CAA ATG CAG GCT TTG GAT AAG GAA TTG AAC GCT CAA 338Arg Ser ValGlu Gln Met Gln Ala Leu Asp Lys Glu Leu Asn Ala Gln
95 100 105AAC GAA GTG ATC TTA AAA AGC GTG ATT GAA GTA GAA GTG AGT GAA AAC 386Asn Glu Val Ile Leu Lys Ser Val Ile Glu Val Glu Val Ser Glu Asn
110 115 120ACT GCT AAA GAA AGG GTT TTA GGG CGC TCT AGG GGG GCT GAT GAT AAT 434Thr Ala Lys Glu Arg Val Leu Gly Arg Ser Arg Gly Ala Asp Asp Asn
125 130 135GAA AAG GTG TTT CAT AAC CGC ATG CGG GTG TTT TTG GAT CCG TTG GGC 482Glu Lys Val Phe His Asn Arg Met Arg Val Phe Leu Asp Pro Leu Gly
140 145 150GAG ATC CAA AAT TTT TAC AAG AAT AAG AAG GTG TAT AAA GCG ATC GAT 530Glu Ile Gln Asn Phe Tyr Lys Asn Lys Lys Val Tyr Lys Ala Ile Asp155 160 165 170GGG GAG AGG AGC ATT GAA GAG ATT GTG GGC GAA ATG CAA GAG TAT ATC 578Gly Glu Arg Ser Ile Glu Glu Ile Val Gly Glu Met Gln Glu Tyr Ile
175 180 185TTG TCT TTC GGT AAT TAAAATGCAC TCTCAAGGAG AATAGCTGTG ATTTCTG 630Leu Ser Phe Gly Asn
190
(2) Data in sequence 766:
(i) sequence characteristics:
(A) length: 191 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 766: met Lys Gln Leu Phe Leu Ile Ile Gly Ala Pro Gly Ser Gly Lys Thr 151015 Thr Asp Ala Glu Leu Ile Ala Lys Asn Asn SerGlu Thr Ile Ala His
20 25 30Phe Ser Thr Gly Asp Leu Leu Arg Ala Glu Ser Ala Lys Lys Thr Glu
35 40 45Arg Gly Leu Leu Ile Glu Lys Phe Thr Ser Gln Gly Glu Leu Val Pro
50 55 60Leu Glu Ile Val Val Glu Thr Ile Leu Ser Ala Ile Lys Ser Ser Gly65 70 75 80Lys Gly Ile Ile Leu Ile Asp Gly Tyr Pro Arg Ser Val Glu Gln Met
85 90 95Gln Ala Leu Asp Lys Glu Leu Asn Ala Gln Asn Glu Val Ile Leu Lys
100 105 110Ser Val Ile Glu Val Glu Val Ser Glu Asn Thr Ala Lys Glu Arg Val
115 120 125Leu Gly Arg Ser Arg Gly Ala Asp Asp Asn Glu Lys Val Phe His Asn
130 135 140Arg Met Arg Val Phe Leu Asp Pro Leu Gly Glu Ile Gln Asn Phe Tyr145 150 155 160Lys Asn Lys Lys Val Tyr Lys Ala Ile Asp Gly Glu Arg Ser Ile Glu
165 170 175Glu Ile Val Gly Glu Met Gln Glu Tyr Ile Leu Ser Phe Gly Asn
180 185 190
(2) Sequence 767 data:
(i) sequence characteristics:
(A) length: 777 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...717
(D) Other information:
(xi) Description of the sequence: sequence 767: AGT TAC CCC CCC CCC CCC AAT CCC ACA CAA GAA ACG CAA CAA GAT TTT 48Ser Tyr Pro Pro Pro Pro Asn Pro Thr Gln Glu Thr Gln Gln Asp Phe 151015 ATT ATT GAA GCA CAA CAA GAT TTG ATT ATT GAA ACG CAA CAA GAC CCC 96Ile Ile Glu Ala Gln Gln Asp Leu Ile Ile Glu Thr Gln Gln Asp Pro
20 25 30AAA GAA CTA CCT GAG TCT TGC AAA ATA ACG CCC CAA AAA ATC TCT TTT 144Lys Glu Leu Pro Glu Ser Cys Lys Ile Thr Pro Gln Lys Ile Ser Phe
35 40 45AAC CAA GTG GTT TTT AAA AAA ATT AAA AGA AAA CTC AAC CGC TTC ATT 192Asn Gln Val Val Phe Lys Lys Ile Lys Arg Lys Leu Asn Arg Phe Ile
50 55 60GGA AGC ATT TTA GCT CGG ACA GAA GTG TAT AAG AAT CTC GTG GCA AAA 240Gly Ser Ile Leu Ala Arg Thr Glu Val Tyr Lys Asn Leu Val Ala Lys65 70 75 80TAC GAT GAA CTC ACA GGA AAA TAC GAA TCA TTA TTG GCA AAA GAG GCA 288Tyr Asp Glu Leu Thr Gly Lys Tyr Glu Ser Leu Leu Ala Lys Glu Ala
85 90 95AAC ATC AAA GAG ACC TTT TGG GAA AGG CGT GCT GAT AGC GAA AAA GAA 336Asn Ile Lys Glu Thr Phe Trp Glu Arg Arg Ala Asp Ser Glu Lys Glu
100 105 110GCC TTT TTT TTA GAG CAT TTT TAC CTC ACT AGC GTG TAT GTG GCT TCT 384Ala Phe Phe Leu Glu His Phe Tyr Leu Thr Ser Val Tyr Val Ala Ser
115 120 125ACA GCA GGA TAC TAT ATC ACG CCT AAG GGC GCT AAA ACC TTT ATA GAA 432Thr Ala Gly Tyr Tyr Ile Thr Pro Lys Gly Ala Lys Thr Phe Ile Glu
130 135 140GCC ACG GAG CGT TTT AAA ATC ATA GAG CCG GTG GAT ATG TTC ATA AAC 480Ala Thr Glu Arg Phe Lys Ile Ile Glu Pro Val Asp Met Phe Ile Asn145 150 155 160AAC CCC ACT TAC CAT GAT GTG GCT AAT TTT ACC TAT TTG CCT TGC CCT 528Asn Pro Thr Tyr His Asp Val Ala Asn Phe Thr Tyr Leu Pro Cys Pro
165 170 175GTT TCT TTA AAC AAG CAT GCT TTC AAT AGC ACC ATT CAA AAT GCA AAA 576Val Ser Leu Asn Lys His Ala Phe Asn Ser Thr Ile Gln Asn Ala Lys
180 185 190AAG CCT GAC ATT TCA TTA AAA CCC CCT AGA AAA TCC TAT TTT GAT AAT 624Lys Pro Asp Ile Ser Leu Lys Pro Pro Arg Lys Ser Tyr Phe Asp Asn
195 200 205CTT TTT TAT GAT CAA TTA AAC ACT AGA AAG TGC TTA AAA GCC TTT CAC 672Leu Phe Tyr Asp Gln Leu Asn Thr Arg Lys Cys Leu Lys Ala Phe His
210 215 220AAA TAC AGC AGA CGA TAC GCT CCT TTA AAA ACC CCT AAA GAG GTT TAAAA 722Lys Tyr Ser Arg Arg Tyr Ala Pro Leu Lys Thr Pro Lys Glu Val225 230 235AGAGCGGGCT TTATGTTAGA ATAAGTCTTT TTATTCAAAG GAGATTGCAA TGAAT 777
(2) Sequence 768 data:
(i) sequence characteristics:
(A) length: 239 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description ofthe sequence: sequence 768: ser Tyr Pro Pro Pro Pro Asn Pro Thr Gln Glu Thr Gln Gln Asp Phe 151015 Ile Ile Glu Ala Gln Gln Asp Leu Ile Ile Glu Thr Gln Gln Asp Pro
20 25 30Lys Glu Leu Pro Glu Ser Cys Lys Ile Thr Pro Gln Lys Ile Ser Phe
35 40 45Asn Gln Val Val Phe Lys Lys Ile Lys Arg Lys Leu Asn Arg Phe Ile
50 55 60Gly Ser Ile Leu Ala Arg Thr Glu Val Tyr Lys Asn Leu Val Ala Lys65 70 75 80Tyr Asp Glu Leu Thr Gly Lys Tyr Glu Ser Leu Leu Ala Lys Glu Ala
85 90 95Asn Ile Lys Glu Thr Phe Trp Glu Arg Arg Ala Asp Ser Glu Lys Glu
100 105 110Ala Phe Phe Leu Glu His Phe Tyr Leu Thr Ser Val Tyr Val Ala Ser
115 120 125Thr Ala Gly Tyr Tyr Ile Thr Pro Lys Gly Ala Lys Thr Phe Ile Glu
130 135 140Ala Thr Glu Arg Phe Lys Ile Ile Glu Pro Val Asp Met Phe Ile Asn145 150 155 160Asn Pro Thr Tyr His Asp Val Ala Asn Phe Thr Tyr Leu Pro Cys Pro
165 170 175Val Ser Leu Asn Lys His Ala Phe Asn Ser Thr Ile Gln Asn Ala Lys
180 185 190Lys Pro Asp Ile Ser Leu Lys Pro Pro Arg Lys Ser Tyr Phe Asp Asn
195 200 205Leu Phe Tyr Asp Gln Leu Asn Thr Arg Lys Cys Leu Lys Ala Phe His
210 215 220Lys Tyr Ser Arg Arg Tyr Ala Pro Leu Lys Thr Pro Lys Glu Val225 230 235
(2) Sequence 769 data:
(i) sequence characteristics:
(A) length: 1350bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...1252
(D) Other information:
(xi) Description of the sequence: sequence 769: AAGTGGAAAA TTTAGCTAAA GAAAGAGAAA AAAGTTTAAA GGATTAGGC ATG ATC AAT 58
Met Ile Asn
1AAG TTT AAA AAT TTT GTG AGC AAC TAC CAG CAA TCT AAC CAC TAT AAA 106Lys Phe Lys Asn Phe Val Ser Asn Tyr Gln Gln Ser Asn His Tyr Lys
5 10 15GAG CCT TTA GGT TTT GGC ATT GCC AGA GTG GAT ATT GCC CCT ATT TCC 154Glu Pro Leu Gly Phe Gly Ile Ala Arg Val Asp Ile Ala Pro Ile Ser20 25 30 35AAA AAG ATT TTA TGC GCC ACT TAC CCT GTT TTG AAT TGG AAA GAT GAA 202Lys Lys Ile Leu Cys Ala Thr Tyr Pro Val Leu Asn Trp Lys Asp Glu
40 45 50AAT TTA GGC TCT TAT GCG GTG TTT TGC AAC TCG CTT TCA AAA GAA AAA 250Asn Leu Gly Ser Tyr Ala Val Phe Cys Asn Ser Leu Ser Lys Glu Lys
55 60 65ATC CTA AAA GAG AGC GCG AGC GAG CGC GTT ATT GAG ATT GATGAA AGT 298Ile Leu Lys Glu Ser Ala Ser Glu Arg Val Ile Glu Ile Asp Glu Ser
70 75 80TTT GTG TTA AAA GCG TTG GAT TTT TAT ACG CCC TTT TTG AAT GAA GCC 346Phe Val Leu Lys Ala Leu Asp Phe Tyr Thr Pro Phe Leu Asn Glu Ala
85 90 95TAT TCT AAT AAA ATG GCT CAT AAA AAC ATC CAA GTG GTT TTA GAG CTT 394Tyr Ser Asn Lys Met Ala His Lys Asn Ile Gln Val Val Leu Glu Leu100 105 110 115TTA AAG GCT TTA GAA GAA AAT CGT TTG AAA AAT AGC GAT GGG GAG TCT 442Leu Lys Ala Leu Glu Glu Asn Arg Leu Lys Asn Ser Asp Gly Glu Ser
120 125 130CTT TAT CGC TTG GTG ATC TTG TAT GAA GAT AAG CCT TGC GAG AGC GTG 490Leu Tyr Arg Leu Val Ile Leu Tyr Glu Asp Lys Pro Cys Glu Ser Val
135 140 145GAG AGC GCG TAT ATG AAA CTT TTA GCG CTC TCT TTA GGT AAA GCC CCT 538Glu Ser Ala Tyr Met Lys Leu Leu Ala Leu Ser Leu Gly Lys Ala Pro
150 155 160TTG AGG AGT TTG AAT TTA GAG GGT ATT TTT AAC CAG CTT TCT AAT GCG 586Leu Arg Ser Leu Asn Leu Glu Gly Ile Phe Asn Gln Leu Ser Asn Ala
165 170 175GCC TGG AGC GGT AAC AAG CCC TAT GAA TTA GAA TGG CTT AGA ATG AAC 634Ala Trp Ser Gly Asn Lys Pro Tyr Glu Leu Glu Trp Leu Arg Met Asn180 185 190 195GAA GTG GCT TTA AAA ATG CGA GAC CAT TTC CCT AGC ATT GAT TTC ATA 682Glu Val Ala Leu Lys Met Arg Asp His Phe Pro Ser Ile Asp Phe Ile
200 205 210GAT AAA TTC CCA CGC TAT TTG ATG CAA TTA ATC CCT GAG TTT GAT AAT 730Asp Lys Phe Pro Arg Tyr Leu Met Gln Leu Ile Pro Glu Phe Asp Asn
215 220 225ATC CGC TTA TTG GAT AGC TCA AAA ACG CGC TTT GGG GCG TAT TTA GGG 778Ile Arg Leu Leu Asp Ser Ser Lys Thr Arg Phe Gly Ala Tyr Leu Gly
230 235 240ACT GGA GGT TAT ACC CAA ATG CCT GGG GCT AGT TAT GTG AAT TTT AAC 826Thr Gly Gly Tyr Thr Gln Met Pro Gly Ala Ser Tyr Val Asn Phe Asn
245 250 255GCA GGG GCT ATG GGA GTG TGC ATG AAT GAG GGG CGT ATT TCT TCA TCG 874Ala Gly Ala Met Gly Val Cys Met Asn Glu Gly Arg Ile Ser Ser Ser260 265 270 275GTG GTG GTT GGA GCA GGC ACT GAT ATT GGT GGG GGA GCG AGC GTG TTA 922Val Val Val Gly Ala Gly Thr Asp Ile Gly Gly Gly Ala Ser Val Leu
280 285 290GGC GTT TTA AGT GGA GGG AAT AAC AAC CCC ATT AGC ATC GGG AAA AAT 970Gly Val Leu Ser Gly Gly Asn Asn Asn Pro Ile Ser Ile Gly Lys Asn
295 300 305TGT TTG CTA GGG GCT AAT AGC GTT ACT GGA ATT AGT CTA GGC GAT GGC 1018Cys Leu Leu Gly Ala Asn Ser Val Thr Gly Ile Ser Leu Gly Asp Gly
310 315 320TGT ATC GTG GAT GCA GGC GTT GCG ATA CTA GCC GGG AGC GTG ATA GAA 1066Cys Ile Val Asp Ala Gly Val Ala Ile Leu Ala Gly Ser Val Ile Glu
325 330 335ATT GAA GAA AAT GAG TTT AAA AAG CTT TTA GAA GTG AAT AGC GCT TTA 1114Ile Glu Glu Asn Glu Phe Lys Lys Leu Leu Glu Val Asn Ser Ala Leu340 345 350 355GAA AAA CAT GCC AAC AAC CTT TAC AAA GGC AAA GAA CTT TCC GGA AAA 1162Glu Lys His Ala Asn Asn Leu Tyr Lys Gly Lys Glu Leu Ser Gly Lys
360 365 370AAT GGC GTG CAT TTT CGT TCC AAT AGT CAG AAT GGC AAG CTG ATT GCT 1210Asn Gly Val His Phe Arg Ser Asn Ser Gln Asn Gly Lys Leu Ile Ala
375 380 385TTT AGG AGC GTG AAA AAA ATT GAG TTG AAT CAA AAC CTG CAT TAAGGATTA 1261Phe Arg Ser Val Lys Lys Ile Glu Leu Asn Gln Asn Leu His
390 395 400AAAGAATGCT CAAAAAAAGT TTGTTATTGC TTGTTTTTTT AGTCTTACAG CTTAGCGGCG 1321CTGAAGAAAA CAATCAAGCC CCAAAAAAC 1350
(2) Sequence 770 data:
(i) sequence characteristics:
(A) length: 401 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 770: met Ile Asn Lys Phe Lys Asn Phe Val Ser Asn Tyr Gln Gln Ser Asn 151015 His Tyr Lys Glu Pro Leu Gly Phe Gly Ile Ala Arg Val Asp Ile Ala
20 25 30Pro Ile Ser Lys Lys Ile Leu Cys Ala Thr Tyr Pro Val Leu Asn Trp
35 40 45Lys Asp Glu Asn Leu Gly Ser Tyr Ala Val Phe Cys Asn Ser Leu Ser
50 55 60Lys Glu Lys Ile Leu Lys Glu Ser Ala Ser Glu Arg Val Ile Glu Ile65 70 75 80Asp Glu Ser Phe Val Leu Lys Ala Leu Asp Phe Tyr Thr Pro Phe Leu
85 90 95Asn Glu Ala Tyr Ser Asn Lys Met Ala His Lys Asn Ile Gln Val Val
100105 110Leu Glu Leu Leu Lys Ala Leu Glu Glu Asn Arg Leu Lys Asn Ser Asp
115 120 125Gly Glu Ser Leu Tyr Arg Leu Val Ile Leu Tyr Glu Asp Lys Pro Cys
130 135 140Glu Ser Val Glu Ser Ala Tyr Met Lys Leu Leu Ala Leu Ser Leu Gly145 150 155 160Lys Ala Pro Leu Arg Ser Leu Asn Leu Glu Gly Ile Phe Asn Gln Leu
165 170 175Ser Asn Ala Ala Trp Ser Gly Asn Lys Pro Tyr Glu Leu Glu Trp Leu
180 185 190Arg Met Asn Glu Val Ala Leu Lys Met Arg Asp His Phe Pro Ser Ile
195 200 205Asp Phe Ile Asp Lys Phe Pro Arg Tyr Leu Met Gln Leu Ile Pro Glu
210 215 220Phe Asp Asn Ile Arg Leu Leu Asp Ser Ser Lys Thr Arg Phe Gly Ala225 230 235 240Tyr Leu Gly Thr Gly Gly Tyr Thr Gln Met Pro Gly Ala Ser Tyr Val
245 250 255Asn Phe Asn Ala Gly Ala Met Gly Val Cys Met Asn Glu Gly Arg Ile
260 265 270Ser Ser Ser Val Val Val Gly Ala Gly Thr Asp Ile Gly Gly Gly Ala
275 280 285Ser Val Leu Gly Val Leu Ser Gly Gly Asn Asn Asn Pro Ile Ser Ile
290 295 300Gly Lys Asn Cys Leu Leu Gly Ala Asn Ser Val Thr Gly Ile Ser Leu305 310 315 320Gly Asp Gly Cys Ile Val Asp Ala Gly Val Ala Ile Leu Ala Gly Ser
325 330335Val Ile Glu Ile Glu Glu Asn Glu Phe Lys Lys Leu Leu Glu Val Asn
340 345 350Ser Ala Leu Glu Lys His Ala Asn Asn Leu Tyr Lys Gly Lys Glu Leu
355 360 365Ser Gly Lys Asn Gly Val His Phe Arg Ser Asn Ser Gln Asn Gly Lys
370 375 380Leu Ile Ala Phe Arg Ser Val Lys Lys Ile Glu Leu Asn Gln Asn Leu385 390 395 400His
(2) Sequence 771 data:
(i) sequence characteristics:
(A) length: 1304 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...1201
(D) Other information:
(xi) Description of the sequence: sequence 771: TTATTTTTAT TATGTTAAGA TAATGAAAAT TTCTAATTAA GGAGTGGTC ATG TTC TAC 58
Met Phe Tyr
1GAT GAA AAA AAG ACC TAT CAA AAG ATT GAA GAA CGC CTT GAT ATA GTC 106Asp Glu Lys Lys Thr Tyr Gln Lys Ile Glu Glu Arg Leu Asp Ile Val
5 10 15CGT TCG TTT AAC GCT CAC AAC GAG CAT AAA AAC TTG CAA GAC GAG TTT 154Arg Ser Phe Asn Ala His Asn Glu His Lys Asn Leu Gln Asp Glu Phe20 2530 35AAA GGG GCG GGC ATT TCT AGG CGC GAT TTA TTG AAG TGG GCG GGC ATG 202Lys Gly Ala Gly Ile Ser Arg Arg Asp Leu Leu Lys Trp Ala Gly Met
40 45 50ATG AGC ACA GCG TTA GCC TTG CCG GCT AGT TTT GCT CCC TTG ACT TTG 250Met Ser Thr Ala Leu Ala Leu Pro Ala Ser Phe Ala Pro Leu Thr Leu
55 60 65AAG GCG GTG GAA GTG GCT AAC AGA TTG CCC GTG ATT TGG TTG CAC ATG 298Lys Ala Val Glu Val Ala Asn Arg Leu Pro Val Ile Trp Leu His Met
70 75 80GCA GAA TGC ACC GGT TGT AGC GAA AGT TTG TTA AGG AGC GCA GAC CCC 346Ala Glu Cys Thr Gly Cys Ser Glu Ser Leu Leu Arg Ser Ala Asp Pro
85 90 95ACC ATT GAT AGC ATT ATC TTT GAT TAC ATC AAC CTA GAA TAC CAT GAG 394Thr Ile Asp Ser Ile Ile Phe Asp Tyr Ile Asn Leu Glu Tyr His Glu100 105 110 115ACC ATC ATG GTA GCG AGC GGT TTT CAA GCT GAA AAA AGC TTG CAT GAC 442Thr Ile Met Val Ala Ser Gly Phe Gln Ala Glu Lys Ser Leu His Asp
120 125 130GCC ATA GAA AAG CAT AAA AAC AAT TAC ATT TTA ATG GTA GAA GGG GGT 490Ala Ile Glu Lys His Lys Asn Asn Tyr Ile Leu Met Val Glu Gly Gly
135 140 145ATC CCC CAA GGC ACG GAA TAC TTC CTC ACT CAA GGC CCA AAC GCT GAA 538Ile Pro Gln Gly Thr Glu Tyr Phe Leu Thr Gln Gly Pro Asn Ala Glu
150 155 160ACG GGA GCT GAA GAG TGT AGG AAA GCC GCT CAA TAC GCA GCC GCT ATT 586Thr Gly Ala Glu Glu Cys Arg Lys Ala Ala Gln Tyr Ala Ala Ala Ile
165 170 175TTT GCC ATA GGC ACA TGC TCAAGT TTT GGG GGC GTT CAA GCG GCT TAC 634Phe Ala Ile Gly Thr Cys Ser Ser Phe Gly Gly Val Gln Ala Ala Tyr180 185 190 195CCT AAC CCC TCT AAC GCG CAA CCC TTG CAT AAA ATC ATT GAT AAA CCC 682Pro Asn Pro Ser Asn Ala Gln Pro Leu His Lys Ile Ile Asp Lys Pro
200 205 210GTG ATC AAT GTT CCT GGT TGC CCG CCT AGT GAA AAA AAT ATC GTG GGT 730Val Ile Asn Val Pro Gly Cys Pro Pro Ser Glu Lys Asn Ile Val Gly
215 220 225AAT GTG CTT TAT TAC TTG ATG TTT GGG GCT CTC CCT AAA TTG GAT GCG 778Asn Val Leu Tyr Tyr Leu Met Phe Gly Ala Leu Pro Lys Leu Asp Ala
230 235 240TAT AAC CGC CCC TCT TGG GCT TAT GGG AAC AGG ATC CAT GAT TTG TGC 826Tyr Asn Arg Pro Ser Trp Ala Tyr Gly Asn Arg Ile His Asp Leu Cys
245 250 255GAA AGG AGA GGG CAT TTT GAT GCG GGC GAA TTT GTG GAG CAT TTT GGC 874Glu Arg Arg Gly His Phe Asp Ala Gly Glu Phe Val Glu His Phe Gly260 265 270 275GAT GAA AAC GCT AAA AGG GGC TTT TGT TTG TAT AAA ATG GGC TGT AAA 922Asp Glu Asn Ala Lys Arg Gly Phe Cys Leu Tyr Lys Met Gly Cys Lys
280 285 290GGG CCT TAC ACT TTC AAC AAT TGC TCC AAA CTC CGC TTC AAT TCA CAC 970Gly Pro Tyr Thr Phe Asn Asn Cys Ser Lys Leu Arg Phe Asn Ser His
295 300 305ACC TCT TGG CCC ATA GGT GCA GGG CAT GGG TGT ATA GGG TGT TCT GAG 1018Thr Ser Trp Pro Ile Gly Ala Gly His Gly Cys Ile Gly Cys Ser Glu
310 315 320CCT AAT TTT TGG GAT ACG ATG AGT CCT TTT GAA GAG CCT TTA GCG AAT 1066Pro Asn Phe Trp Asp Thr Met Ser Pro Phe Glu Glu Pro Leu Ala Asn
325 330 335CGT TCC ATT AAA ACC GCT TTT GAC GGA TTA GGG GCT GAT AAA GTA GCG 1114Arg Ser Ile Lys Thr Ala Phe Asp Gly Leu Gly Ala Asp Lys Val Ala340 345 350 355GAT AAA GTA GGC ACG ACT TTG CTG AGC GCA ACC GCT ATT GGC ATT GTT 1162Asp Lys Val Gly Thr Thr Leu Leu Ser Ala Thr Ala Ile Gly Ile Val
360 365 370GCG CAT GCG CTC CTT TCT AAA GCG ATC AAA AAC AAA GAG TAAGGGATTA AC 1213Ala His Ala Leu Leu Ser Lys Ala Ile Lys Asn Lys Glu
375 380ATGTCAAAAA AAATCGTAGT CGATCCTATC ACTAGGATTG AGGGGCATTT AAGGATTGAA 1273GTGATCGTAG ATGATGATAA CGTGATCACT G 1304
(2) Sequence 772 data:
(i) sequence characteristics:
(A) length: 384 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 772: met Phe Tyr Asp Glu Lys Lys Thr Tyr Gln Lys Ile Glu Glu Arg Leu 151015 Asp Ile Val Arg Ser Phe Asn Ala His Asn Glu His Lys Asn Leu Gln
20 25 30Asp Glu Phe Lys Gly Ala Gly Ile Ser Arg Arg Asp Leu Leu Lys Trp
35 40 45Ala Gly Met Met Ser Thr Ala Leu Ala Leu Pro Ala Ser Phe Ala Pro
50 55 60Leu Thr Leu Lys Ala Val Glu Val Ala Asn Arg Leu Pro Val Ile Trp65 7075 80Leu His Met Ala Glu Cys Thr Gly Cys Ser Glu Ser Leu Leu Arg Ser
85 90 95Ala Asp Pro Thr Ile Asp Ser Ile Ile Phe Asp Tyr Ile Asn Leu Glu
100 105 110Tyr His Glu Thr Ile Met Val Ala Ser Gly Phe Gln Ala Glu Lys Ser
115 120 125Leu His Asp Ala Ile Glu Lys His Lys Asn Asn Tyr Ile Leu Met Val
130 135 140Glu Gly Gly Ile Pro Gln Gly Thr Glu Tyr Phe Leu Thr Gln Gly Pro145 150 155 160Asn Ala Glu Thr Gly Ala Glu Glu Cys Arg Lys Ala Ala Gln Tyr Ala
165 170 175Ala Ala Ile Phe Ala Ile Gly Thr Cys Ser Ser Phe Gly Gly Val Gln
180 185 190Ala Ala Tyr Pro Asn Pro Ser Asn Ala Gln Pro Leu His Lys Ile Ile
195 200 205Asp Lys Pro Val Ile Asn Val Pro Gly Cys Pro Pro Ser Glu Lys Asn
210 215 220Ile Val Gly Asn Val Leu Tyr Tyr Leu Met Phe Gly Ala Leu Pro Lys225 230 235 240Leu Asp Ala Tyr Asn Arg Pro Ser Trp Ala Tyr Gly Asn Arg Ile His
245 250 255Asp Leu Cys Glu Arg Arg Gly His Phe Asp Ala Gly Glu Phe Val Glu
260 265 270His Phe Gly Asp Glu Asn Ala Lys Arg Gly Phe Cys Leu Tyr Lys Met
275 280 285Gly Cys Lys Gly Pro Tyr Thr Phe Asn Asn Cys Ser Lys Leu Arg Phe
290 295 300Asn Ser His Thr Ser Trp Pro Ile Gly Ala Gly His Gly Cys Ile Gly305 310 315 320Cys Ser Glu Pro Asn Phe Trp Asp Thr Met Ser Pro Phe Glu Glu Pro
325 330 335Leu Ala Asn Arg Ser Ile Lys Thr Ala Phe Asp Gly Leu Gly Ala Asp
340 345 350Lys Val Ala Asp Lys Val Gly Thr Thr Leu Leu Ser Ala Thr Ala Ile
355 360 365Gly Ile Val Ala His Ala Leu Leu Ser Lys Ala Ile Lys Asn Lys Glu
370 375 380
(2) Sequence 773 data:
(i) sequence characteristics:
(A) length: 810bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 39...710
(D) Other information:
(xi) Description of the sequence: sequence 773: TAGAGCCTAA TTTCGCTAAA TTCTAAAAAG GGTTACGC ATG GAT AAA ATG AAT AAG 56
Met Asp Lys Met Asn Lys
1 5GTC GTT TTA CAC AAA GAA TAT TCC GGT TTT GTG CGC TTT TTC CAT TGG 104Val Val Leu His Lys Glu Tyr Ser Gly Phe Val Arg Phe Phe His Trp
10 1520GTT AGG GCT TTG AGT ATT TTC GCT TTA ATC GCT ACA GGG TTT TAC ATC 152Val Arg Ala Leu Ser Ile Phe Ala Leu Ile Ala Thr Gly Phe Tyr Ile
25 30 35GCT TAC CCT TTT TTG CAG CCT AAT TCC AGC TTT TAT AAA GGG GTG TAT 200Ala Tyr Pro Phe Leu Gln Pro Asn Ser Ser Phe Tyr Lys Gly Val Tyr
40 45 50CTT TTA CAA GCT TAT GTG CGT TCT TTT CAT GTC ATG TTT GGG TTT TTG 248Leu Leu Gln Ala Tyr Val Arg Ser Phe His Val Met Phe Gly Phe Leu55 60 65 70CTC ATT AGC GCA TTA ATC TTT AGA ACC TAT CTT TTT TTC ACT AAA GAA 296Leu Ile Ser Ala Leu Ile Phe Arg Thr Tyr Leu Phe Phe Thr Lys Glu
75 80 85AGC TTG ATG GAA CGC AAG AGT TTT AGC CAA CTT TTA AGC CCA AAA GCC 344Ser Leu Met Glu Arg Lys Ser Phe Ser Gln Leu Leu Ser Pro Lys Ala
90 95 100TGG ATT GAT CAG ATG AAA GCG TAT TTT CTT ATC AGC GGC AAA CCC CAC 392Trp Ile Asp Gln Met Lys Ala Tyr Phe Leu Ile Ser Gly Lys Pro His
105 110 115ACT AAA GGA GCG TAT AAC CCT ATC CAA CTC GTG GCT TAT TCC ACT TTG 440Thr Lys Gly Ala Tyr Asn Pro Ile Gln Leu Val Ala Tyr Ser Thr Leu
120 125 130ATT GTT TTG ATC GTG TTG ATG AGT TTG AGC GGG ATG GTG CTG TAT TAT 488Ile Val Leu Ile Val Leu Met Ser Leu Ser Gly Met Val Leu Tyr Tyr135 140 145 150AAT GTC TAT CAT GCG GGG CTT GGA GCG TTT TTA GGA AGC GCT TTT AAG 536Asn Val Tyr His Ala Gly Leu Gly Ala Phe Leu Gly Ser Ala Phe Lys
155 160 165TGG TTT GAA ACG CTT TGT GGA GGG TTA GCG AAT GTT CGT TTC ATC CAC 584Trp Phe Glu Thr Leu Cys Gly Gly Leu Ala Asn Val Arg Phe Ile His
170 175 180CAC TTA GCG ACT TGG GGG TTT ATT TTG TTT GTC CCT GTG CAT GTT TAT 632His Leu Ala Thr Trp Gly Phe Ile Leu Phe Val Pro Val His Val Tyr
185 190 195ATG GTG TTT TTC CAT TCT ATC AGG TAT GAA AGT TCG GGG GCG GAT TCT 680Met Val Phe Phe His Ser Ile Arg Tyr Glu Ser Ser Gly Ala Asp Ser
200 205 210ATG ATT AAT GGC TAT GGT TAT ACC AAA GAA TGAGTCAAAA AATCCTAATT CTA 733Met Ile Asn Gly Tyr Gly Tyr Thr Lys Glu215 220GGTATTGGCA ATATCCTTTT TGGCGATGAA GGGATTGGGG TGCATTTAGC CCACTACCTC 793AAAAAAAATT TTTCTTT 810
(2) Sequence 774 data:
(i) sequence characteristics:
(A) length: 224 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 774: met Asp Lys Met Asn Lys Val Val Leu His Lys Glu Tyr Ser Gly Phe 151015 Val Arg Phe Phe His Trp Val Arg Ala Leu Ser Ile Phe Ala Leu Ile
20 25 30Ala Thr Gly Phe Tyr Ile Ala Tyr Pro Phe Leu Gln Pro Asn Ser Ser
35 40 45Phe Tyr Lys Gly Val Tyr Leu Leu Gln Ala Tyr Val Arg Ser Phe His
50 55 60Val Met Phe Gly Phe Leu Leu Ile Ser Ala Leu Ile Phe Arg Thr Tyr65 7075 80Leu Phe Phe Thr Lys Glu Ser Leu Met Glu Arg Lys Ser Phe Ser Gln
85 90 95Leu Leu Ser Pro Lys Ala Trp Ile Asp Gln Met Lys Ala Tyr Phe Leu
100 105 110Ile Ser Gly Lys Pro His Thr Lys Gly Ala Tyr Asn Pro Ile Gln Leu
115 120 125Val Ala Tyr Ser Thr Leu Ile Val Leu Ile Val Leu Met Ser Leu Ser
130 135 140Gly Met Val Leu Tyr Tyr Asn Val Tyr His Ala Gly Leu Gly Ala Phe145 150 155 160Leu Gly Ser Ala Phe Lys Trp Phe Glu Thr Leu Cys Gly Gly Leu Ala
165 170 175Asn Val Arg Phe Ile His His Leu Ala Thr Trp Gly Phe Ile Leu Phe
180 185 190Val Pro Val His Val Tyr Met Val Phe Phe His Ser Ile Arg Tyr Glu
195 200 205Ser Ser Gly Ala Asp Ser Met Ile Asn Gly Tyr Gly Tyr Thr Lys Glu
210 215 220
(2) Sequence 775 data:
(i) sequence characteristics:
(A) length: 1543 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 32...1495
(D) Other information:
(xi) Description of the sequence: sequence 775: AAGCCTGAAT TTTACGCCCC TTTTAGAGCG A ATG GCA TGC AAT TTG CAA GCG 52
Met Ala Cys Asn Leu Gln Ala
1 5CGT TTT TAT AGC GTT TAT AAG GAT AAT ACC ACT TCT TTC TAC CTC CAA 100Arg Phe Tyr Ser Val Tyr Lys Asp Asn Thr Thr Ser Phe Tyr Leu Gln
10 15 20GCG AGC GCT GAA ACC ACT TTA GAG TTC GCG CAA AAA CTC AGC GAA ATT 148Ala Ser Ala Glu Thr Thr Leu Glu Phe Ala Gln Lys Leu Ser Glu Ile
25 30 35CTG CCC TTT TCT TTA GAT TTT AGC TTT TTG TCT TTA AAG GAA ATC ACA 196Leu Pro Phe Ser Leu Asp Phe Ser Phe Leu Ser Leu Lys Glu Ile Thr40 45 50 55GAG CCT TTA GAT GAA AAT CTT TTC CAA ACA GCA AGC CTT TCA AAG CCC 244Glu Pro Leu Asp Glu Asn Leu Phe Gln Thr Ala Ser Leu Ser Lys Pro
60 65 70CTT TTT ATG AAC GCT AAA GAG CAT CAA GAT TTT TTA GAC AAA AAT TCA 292Leu Phe Met Asn Ala Lys Glu His Gln Asp Phe Leu Asp Lys Asn Ser
75 80 85TCT TTG TAT GCC GAT ACT CTG GGC TTG ATT AAA AAC ACC GCT TTT AAG 340Ser Leu Tyr Ala Asp Thr Leu Gly Leu Ile Lys Asn Thr Ala Phe Lys
90 95 100GGG GAT ATA ATC CAT AGC CCT AAA GAG CTT ATA GAT TGC TTA ACC CAA 388Gly Asp Ile Ile His Ser Pro Lys Glu Leu Ile Asp Cys Leu Thr Gln
105 110 115TTA AAA GGC ATG CTC AAA ACG CAA GAT TTT ATC CCT ATT TTC ACT TCT 436Leu Lys Gly Met Leu Lys Thr Gln Asp Phe Ile Pro Ile Phe Thr Ser120125 130 135AGA GAG GCG TTA TCC CTT TCT TTA AAA AAT CCC TCT CCA AGC GTT ATT 484Arg Glu Ala Leu Ser Leu Ser Leu Lys Asn Pro Ser Pro Ser Val Ile
140 145 150TTT AGC GAT CTT TCT AGC GTT TTG AGC TGC ACT AAA TTG CCT TTA GAG 532Phe Ser Asp Leu Ser Ser Val Leu Ser Cys Thr Lys Leu Pro Leu Glu
155 160 165GAC GCT AAA TAT TTG GCC AGT TTG GAA AAA CCC TCC ATC AAA GCC CCA 580Asp Ala Lys Tyr Leu Ala Ser Leu Glu Lys Pro Ser Ile Lys Ala Pro
170 175 180TTA AAA AGC GTG TTT AAA GAC ACT TTC AAA AAC GAT GAA ATC ATC GCC 628Leu Lys Ser Val Phe Lys Asp Thr Phe Lys Asn Asp Glu Ile Ile Ala
185 190 195CAG CTA CCC TAT GAC CCC ATA TTG AAT TTA TTG TGC CAT ATT TTA CAA 676Gln Leu Pro Tyr Asp Pro Ile Leu Asn Leu Leu Cys His Ile Leu Gln200 205 210 215GAT GAG GGG ATA GAA TTT GTT TTT ATG CAT GAA AGC CGT TCT TGT GAA 724Asp Glu Gly Ile Glu Phe Val Phe Met His Glu Ser Arg Ser Cys Glu
220 225 230GCG CTT TTG TAT TAT GAA GCG CTT TTT AAA ACC CCT AAA CGC TTG ATC 772Ala Leu Leu Tyr Tyr Glu Ala Leu Phe Lys Thr Pro Lys Arg Leu Ile
235 240 245ACA CCC ACT AAA AAA TTC GTG CTA GAA AAT AAT TTT TCT ACC TTT CCC 820Thr Pro Thr Lys Lys Phe Val Leu Glu Asn Asn Phe Ser Thr Phe Pro
250 255 260TTT AAA GAT GAA TTA GAG TTT TTA AGC GCA ACC CCC AAT TCT ATC GTT 868Phe Lys Asp Glu Leu Glu Phe Leu Ser Ala Thr Pro Asn Ser Ile Val
265 270 275TTG TAT CTC AGT TTC AAG CGC CCT ACA AGG TTG TTA TTG CAT GCT AAT 916Leu Tyr Leu Ser Phe Lys Arg Pro Thr Arg Leu Leu Leu His Ala Asn280 285 290 295GGT TCT TTA AAA ACG CTT TTA AGC GTC AGT TTT GAT TTT AAC AAA ATG 964Gly Ser Leu Lys Thr Leu Leu Ser Val Ser Phe Asp Phe Asn Lys Met
300 305 310TTT AAC GCG CTC AAA CAA GAT GAA AAA GCC TCC AGA ATG CTA CAA AAC 1012Phe Asn Ala Leu Lys Gln Asp Glu Lys Ala Ser Arg Met Leu Gln Asn
315 320 325TAC GCC ACT AAA TTC CCT GAT TTT TAC GCG CGC ATT GTA GAG CTT TCT 1060Tyr Ala Thr Lys Phe Pro Asp Phe Tyr Ala Arg Ile Val Glu Leu Ser
330 335 340AAA TAC GAT CTA GGG GGC GCG AAT TTA TTG GAT TTT TTT TGC ATT TTA 1108Lys Tyr Asp Leu Gly Gly Ala Asn Leu Leu Asp Phe Phe Cys Ile Leu
345 350 355GGG TTT GTT TTG GGC TAT AGC GAG GAT TTT TGC ACA CAG AGC GTT ATT 1156Gly Phe Val Leu Gly Tyr Ser Glu Asp Phe Cys Thr Gln Ser Val Ile360 365 370 375CCT TTG GCT AAA GAA TGC TTA CGC CCT AAA GGC CCT AGG ATT GAT TAT 1204Pro Leu Ala Lys Glu Cys Leu Arg Pro Lys Gly Pro Arg Ile Asp Tyr
380 385 390AAA ATC CTT AAA GAC AAT TCT TTG AAA ATG GCT TTA AAC TTT TCA AAG 1252Lys Ile Leu Lys Asp Asn Ser Leu Lys Met Ala Leu Asn Phe Ser Lys
395 400 405ATC ATG CAC AGT GCG ATG AGT TTC AGG CTC GCA GGC GTG GAA AAT GAA 1300Ile Met His Ser Ala Met Ser Phe Arg Leu Ala Gly Val Glu Asn Glu
410 415 420ATT TTG AGT TTG GGG ATT TTG GAT TCT TTA GCG GAG TTT TTA GGG AAT 1348Ile Leu Ser Leu Gly Ile Leu Asp Ser Leu Ala Glu Phe Leu Gly Asn
425 430 435TTC ATT TGG GAT AAC GCG CAA AAT TTT AGC GTT CAA GAA GTA ACG ATC 1396Phe Ile Trp Asp Asn Ala Gln Asn Phe Ser Val Gln Glu Val Thr Ile440 445 450 455GCT GGG GAT TTC TTT GGC GAA AAA GTG TTT TTG GAT TTG TTT GTG CGG 1444Ala Gly Asp Phe Phe Gly Glu Lys Val Phe Leu Asp Leu Phe Val Arg
460 465 470TAT TTC CCT AAA ACC CTA GCC CTT AAA ACG CAT GCA TTT TTG GAT TAT 1492Tyr Phe Pro Lys Thr Leu Ala Leu Lys Thr His Ala Phe Leu Asp Tyr
475 480 485GAA TAAGGGCTTA AAAGCGGATG TGCATCATCA GCCCGCCGTC CATGTATT 1543Glu
(2) Sequence 776 data:
(i) sequence characteristics:
(A) length: 488 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 776: met Ala Cys Asn Leu Gln Ala Arg Phe Tyr Ser Val Tyr Lys Asp Asn 151015 Thr Thr Ser Phe Tyr Leu Gln Ala Ser Ala Glu Thr Thr Leu Glu Phe
20 25 30Ala Gln Lys Leu Ser Glu Ile Leu Pro Phe Ser Leu Asp Phe Ser Phe
35 40 45Leu Ser Leu Lys Glu Ile Thr Glu Pro Leu Asp Glu Asn Leu Phe Gln
50 55 60Thr Ala Ser Leu Ser Lys Pro Leu Phe Met Asn Ala Lys Glu His Gln65 70 75 80Asp Phe Leu Asp Lys Asn Ser Ser Leu Tyr Ala Asp Thr Leu Gly Leu
85 90 95Ile Lys Asn Thr Ala Phe Lys Gly Asp Ile Ile His Ser Pro Lys Glu
100 105 110Leu Ile Asp Cys Leu Thr Gln Leu Lys Gly Met Leu Lys Thr Gln Asp
115 120 125Phe Ile Pro Ile Phe Thr Ser Arg Glu Ala Leu Ser Leu Ser Leu Lys
130 135 140Asn Pro Ser Pro Ser Val Ile Phe Ser Asp Leu Ser Ser Val Leu Ser145 150 155 160Cys Thr Lys Leu Pro Leu Glu Asp Ala Lys Tyr Leu Ala Ser Leu Glu
165 170 175Lys Pro Ser Ile Lys Ala Pro Leu Lys Ser Val Phe Lys Asp Thr Phe
180 185 190Lys Asn Asp Glu Ile Ile Ala Gln Leu Pro Tyr Asp Pro Ile Leu Asn
195 200 205Leu Leu Cys His Ile Leu Gln Asp Glu Gly Ile Glu Phe Val Phe Met
210 215 220His Glu Ser Arg Ser Cys Glu Ala Leu Leu Tyr Tyr Glu Ala Leu Phe225 230 235 240Lys Thr Pro Lys Arg Leu Ile Thr Pro Thr Lys Lys Phe Val Leu Glu
245 250 255Asn Asn Phe Ser Thr Phe Pro Phe Lys Asp Glu Leu Glu Phe Leu Ser
260 265 270Ala Thr Pro Asn Ser Ile Val Leu Tyr Leu Ser Phe Lys Arg Pro Thr
275 280 285Arg Leu Leu Leu His Ala Asn Gly Ser Leu Lys Thr Leu Leu Ser Val
290 295300Ser Phe Asp Phe Asn Lys Met Phe Asn Ala Leu Lys Gln Asp Glu Lys305 310 315 320Ala Ser Arg Met Leu Gln Asn Tyr Ala Thr Lys Phe Pro Asp Phe Tyr
325 330 335Ala Arg Ile Val Glu Leu Ser Lys Tyr Asp Leu Gly Gly Ala Asn Leu
340 345 350Leu Asp Phe Phe Cys Ile Leu Gly Phe Val Leu Gly Tyr Ser Glu Asp
355 360 365Phe Cys Thr Gln Ser Val Ile Pro Leu Ala Lys Glu Cys Leu Arg Pro
370 375 380Lys Gly Pro Arg Ile Asp Tyr Lys Ile Leu Lys Asp Asn Ser Leu Lys385 390 395 400Met Ala Leu Asn Phe Ser Lys Ile Met His Ser Ala Met Ser Phe Arg
405 410 415Leu Ala Gly Val Glu Asn Glu Ile Leu Ser Leu Gly Ile Leu Asp Ser
420 425 430Leu Ala Glu Phe Leu Gly Asn Phe Ile Trp Asp Asn Ala Gln Asn Phe
435 440 445Ser Val Gln Glu Val Thr Ile Ala Gly Asp Phe Phe Gly Glu Lys Val
450 455 460
Phe Leu Asp Leu Phe Val Arg Tyr Phe Pro Lys Thr Leu Ala Leu Lys465 470 475 480Thr His Ala Phe Leu Asp Tyr Glu
485
(2) Sequence 777 data:
(i) sequence characteristics:
(A) length: 715bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 17...694
(D) Other information:
(xi) Description of the sequence: sequence 777: TTTTTAAGGA ATTTTG ATG GAA CAA AAA ATT TGC GTG ATC GGT TTT AGC GGC 52
Met Glu Gln Lys Ile Cys Val Ile Gly Phe Ser Gly
1 5 10GGG CAA GAC AGC ACC ACT TTA GCC GTG TGG GCG AAA AAG CGT TTT AAA 100Gly Gln Asp Ser Thr Thr Leu Ala Val Trp Ala Lys Lys Arg Phe Lys
15 20 25AAA GTC TGT TTA GTG GGG TTT GAT TAT GCG CAA AAA CAC TCT GTG GAA 148Lys Val Cys Leu Val Gly Phe Asp Tyr Ala Gln Lys His Ser Val Glu
30 35 40TTA GAA TGC GCT CAA AAA ATC GCT TCT CTT TTA CAA CTC CCT TAT GAA 196Leu Glu Cys Ala Gln Lys Ile Ala Ser Leu Leu Gln Leu Pro Tyr Glu45 50 55 60ATC ATC CCA TTA GAT TTT TTA GAA AAT ATC ACC CGC TCT GCG CTT TTT 244Ile Ile Pro Leu Asp Phe Leu Glu Asn Ile Thr Arg Ser Ala Leu Phe
65 70 75AAA AAC TCT AAC GAT TTA ATA GGG CAT TCG CAT GCG CAA AAT AAA GAT 292Lys Asn Ser Asn Asp Leu lle Gly His Ser His Ala Gln Asn Lys Asp
80 85 90TTA CCC AAT TCT TTT GTG CCT AAT CGT AAC GCT ATT TTT ATC ACC CTT 340Leu Pro Asn Ser Phe Val Pro Asn Arg Asn Ala Ile Phe Ile Thr Leu
95100 105TTG CAT TCT TAC GCG CAA AAA CTA GGG GCT AGC AAT ATC GCT TTA GGA 388Leu His Ser Tyr Ala Gln Lys Leu Gly Ala Ser Asn Ile Ala Leu Gly
110 115 120GTT TCG CAA GCG GAT TTT AGC GGC TAT CCG GAT TGT AAA GAA GAT TTT 436Val Ser Gln Ala Asp Phe Ser Gly Tyr Pro Asp Cys Lys Glu Asp Phe125 130 135 140ATT AAA AGC ATC GAG CAT GCC TTA AAT TTA GGA TCA AAC ACG GCG ATT 484Ile Lys Ser Ile Glu His Ala Leu Asn Leu Gly Ser Asn Thr Ala Ile
145 150 155AAA ATC CTA ACG CCT TTA ATG TTT TTG AAT AAA GCG CAA GAA TTT CAA 532Lys Ile Leu Thr Pro Leu Met Phe Leu Asn Lys Ala Gln Glu Phe Gln
160 165 170ATG GCT AAA GAT TTG GGC GTC TTG GAT TTA GTC ATC AAA GAA ACG CAG 580Met Ala Lys Asp Leu Gly Val Leu Asp Leu Val Ile Lys Glu Thr His
175 180 185ACC TGC TAT CAA GGA GAG CGA AAG ATT TTG CAT GCT TAT GGT TAT GGT 628Thr Cys Tyr Gln Gly Glu Arg Lys Ile Leu His Ala Tyr Gly Tyr Gly
190 195 200TGC GAT AAA TGC CCG GCA TGC CAA TTG AGA AAA AAA GGC TTT GAA GAG 676Cys Asp Lys Cys Pro A1a Cys Gln Leu Arg Lys Lys Gly Phe Glu Glu205 210 215 220TTT CAA GCT AAT AAA AAA TAAGGTTTTT TAAAAAACCA A 715Phe Gln Ala Asn Lys Lys
225
(2) Sequence 778 data:
(i) sequence characteristics:
(A) length: 226 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 778: met Glu Gln Lys Ile Cys Val Ile Gly Phe Ser Gly Gly Gln Asp Ser 151015 Thr Thr Leu Ala Val Trp Ala Lys Lys Arg Phe Lys Lys Val Cys Leu
20 25 30Val Gly Phe Asp Tyr Ala Gln Lys His Ser Val Glu Leu Glu Cys Ala
35 40 45Gln Lys Ile Ala Ser Leu Leu Gln Leu Pro Tyr Glu Ile Ile Pro Leu
50 55 60Asp Phe Leu Glu Asn Ile Thr Arg Ser Ala Leu Phe Lys Asn Ser Asn65 70 75 80Asp Leu Ile Gly His Ser His Ala Gln Asn Lys Asp Leu Pro Asn Ser
85 90 95Phe Val Pro Asn Arg Asn Ala Ile Phe Ile Thr Leu Leu His Ser Tyr
100 105 110Ala Gln Lys Leu Gly Ala Ser Asn Ile Ala Leu Gly Val Ser Gln Ala
115 120 125Asp Phe Ser Gly Tyr Pro Asp Cys Lys Gln Asp Phe Ile Lys Ser Ile
130 135 140Glu His Ala Leu Asn Leu Gly Ser Asn Thr Ala Ile Lys Ile Leu Thr145 150 155 160Pro Leu Met Phe Leu Asn Lys Ala Gln Glu Phe Gln Met Ala Lys Asp
165 170 175Leu Gly Val Leu Asp Leu Val Ile Lys Glu Thr His Thr Cys Tyr Gln
180 185 190Gly Glu Arg Lys Ile Leu His Ala Tyr Gly Tyr Gly Cys Asp Lys Cys
195 200 205Pro Ala Cys Gln Leu Arg LysLys Gly Phe Glu Glu Phe Gln Ala Asn
210 215 220Lys Lys225
(2) Sequence 779 data:
(i) sequence characteristics:
(A) length: 1201bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...1155
(D) Other information:
(xi) Description of the sequence: sequence 779: TCCTCTCATG AGCTTTACTT GGTAGGGGGG TGCGTGCGCG ATTATTTA ATG GGC ATT 57
Met Gly Ile
1ACC CCA AAA GAT TAC GAT TTA ACC TCA AAC GCT TTA GTC AAT GAA AGC 105Thr Pro Lys Asp Tyr Asp Leu Thr Ser Asn Ala Leu Val Asn Glu Ser
5 10 15AAA GAG CTT CTT TTA AAG CGC CAT TTT AGG GTG CTA GAA ACC GGT ATC 153Lys Glu Leu Leu Leu Lys Arg His Phe Arg Val Leu Glu Thr Gly Ile20 25 30 35AAA CAT GGT ACG ATC ACG GCT CTT AAA AAC CAT CAA AGC TAT GAA ATC 201Lys His Gly Thr Ile Thr Ala Leu Lys Asn His Gln Ser Tyr Glu Ile
40 45 50ACA ACT TTT AGA ATT GAA AAG GGG CAT ATC AAA CAC CGA AAG CCT AAA 249Thr Thr Phe Arg Ile Glu Lys Gly His Ile Lys His Arg Lys Pro Lys
5560 65GAA TTG GTT TTT AGC GTT CAT TTA ACA GAC GAT TTA AAG CGG CGC GAT 297Glu Leu Val Phe Ser Val His Leu Thr Asp Asp Leu Lys Arg Arg Asp
70 75 80TTT AGC ATG AAT GCG ATC GCT TAT AGC CCT ACA AAA GGG CTG ATT GAT 345Phe Ser Met Asn Ala Ile Ala Tyr Ser Pro Thr Lys Gly Leu Ile Asp
85 90 95CCT TTT AAA GGG CAG AAT GCG ATT GAA AAT CAA ATG ATT GAA TGC GTG 393Pro Phe Lys Gly Gln Asn Ala Ile Glu Asn Gln Met Ile Glu Cys Val100 105 110 115GGG GAA GCG CGA TTA AGG TTT TTT GAA GAC GCT TTA AGG ATT TTA AGA 441Gly Glu Ala Arg Leu Arg Phe Phe Glu Asp Ala Leu Arg Ile Leu Arg
120 125 130TCG CTG CGA TTC AGT GCA ACT TTA GGC TTT AAG ATA GCG CCA AAC ACC 489Ser Leu Arg Phe Ser Ala Thr Leu Gly Phe Lys Ile Ala Pro Asn Thr
135 140 145AAA GAA GCG GTT TTT GCG TGT AAG GAT TTG TTA AAA CAC CTT TCT AAA 537Lys Glu Ala Val Phe Ala Cys Lys Asp Leu Leu Lys His Leu Ser Lys
150 155 160GAA CGC TTA CAA AGT GAA TTG AAT AAG CTT CTT ATG GGG AAA AAC GCC 585Glu Arg Leu Gln Ser Glu Leu Asn Lys Leu Leu Met Gly Lys Asn Ala
165 170 175TAT GAA GTG GCT AAA GAA TAT CAA GAA ATT TTA GAG TTG GTT ATT CAA 633Tyr Glu Val Ala Lys Glu Tyr Gln Glu Ile Leu Glu Leu Val Ile Gln180 185 190 195GAA AAA ATA GAA AAT TTA GGG TTT TTA AAA AAC GCG CCT TTC AAT CTG 681Glu Lys Ile Glu Asn Leu Gly Phe Leu Lys Asn Ala Pro Phe Asn Leu
200 205 210GAA TTA AGA TTG TTA GGG TTT TTT AAG CAT CAA AAA AGT TTA GAA AGT729Glu Leu Arg Leu Leu Gly Phe Phe Lys His Gln Lys Ser Leu Glu Ser
215 220 225TTA CGC TAC CCT AAA AAA ACG ATC GTT TTA TTT TCC AAA GCT AAA GAA 777Leu Arg Tyr Pro Lys Lys Thr Ile Val Leu Phe Ser Lys Ala Lys Glu
230 235 240TGC CAT AAA TCT TTT TTA AAT ATT CAT AAC AAA ACA GAG TTA AAA TTT 825Cys His Lys Ser Phe Leu Asn Ile His Asn Lys Thr Glu Leu Lys Phe
245 250 255TTA TTG AAA AAC TAC GAT TTA GAG CCT TTT AAT TTG GCT TTA GAT TTT 873Leu Leu Lys Ash Tyr Asp Leu Glu Pro Phe Asn Leu Ala Leu Asp Phe260 265 270 275TAT GCG CTC AAA AAC CCC AAA CAT GCT TTA AAA ATT AAA GGC TTG TTA 921Tyr Ala Leu Lys Asn Pro Lys His Ala Leu Lys Ile Lys Gly Leu Leu
280 285 290AAA GAA ATC TTT GAT TCT AAC GAG CCT TTT AAA AAA GAA CAC TTG GCC 969Lys Glu Ile Phe Asp Ser Asn Glu Pro Phe Lys Lys Glu His Leu Ala
295 300 305CTT AAG GGC GGT GCG CTT CAA AGC TTG GGT TAC CAG CAC CAA AAA ATC 1017Leu Lys Gly Gly Ala Leu Gln Ser Leu Gly Tyr Gln His Gln Lys Ile
310 315 320GGC GAA ATT TTA AAC GCA TGC TTA GAT TTA GTC ATC GCT AAC CCT AAA 1065Gly Glu Ile Leu Asn Ala Cys Leu Asp Leu Val Ile Ala Asn Pro Lys
325 330 335AAT AAC GCT TTA GAA TGG CTG ATT GAA TGG GTT AAG GGT CAT TAT TTA 1113Asn Asn Ala Leu Glu Trp Leu Ile Glu Trp Val Lys Gly His Tyr Leu340 345 350 355CCT AAT GAT ACT ATA AAT CTT TCG CCA ATA GGC AGA AGA AAT TAAAAACAG 1164Pro Asn Asp Thr Ile Asn Leu Ser Pro Ile Gly Arg Arg Asn
360 365AGAAAACATG ATAACGATGA ATGCGATTCA ATGGCCT 1201
(2) Sequence 780 data:
(i) sequence characteristics:
(A) length: 369 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 780: met Gly Ile Thr Pro Lys Asp Tyr Asp Leu Thr Ser Asn Ala Leu Val 151015 Asn Glu Ser Lys Glu Leu Leu Leu Lys Arg His Phe Arg Val Leu Glu
20 25 30Thr Gly Ile Lys His Gly Thr Ile Thr Ala Leu Lys Asn His Gln Ser
35 40 45Tyr Glu Ile Thr Thr Phe Arg Ile Glu Lys Gly His Ile Lys His Arg
50 55 60Lys Pro Lys Glu Leu Val Phe Ser Val His Leu Thr Asp Asp Leu Lys65 70 75 80Arg Arg Asp Phe Ser Met Asn Ala Ile Ala Tyr Ser Pro Thr Lys Gly
85 90 95Leu Ile Asp Pro Phe Lys Gly Gln Asn Ala Ile Glu Asn Gln Met Ile
100 105 110Glu Cys Val Gly Glu Ala Arg Leu Arg Phe Phe Glu Asp Ala Leu Arg
115 120 125Ile Leu Arg Ser Leu Arg Phe Ser Ala Thr Leu Gly Phe Lys Ile Ala
130 135 140Pro Asn Thr Lys Glu Ala Val Phe Ala Cys Lys Asp Leu Leu Lys His145 150 155160Leu Ser Lys Glu Arg Leu Gln Ser Glu Leu Asn Lys Leu Leu Met Gly
165 170 175Lys Asn Ala Tyr Glu Val Ala Lys Glu Tyr Gln Glu Ile Leu Glu Leu
180 185 190Val Ile Gln Gln Lys Ile Glu Asn Leu Gly Phe Leu Lys Asn Ala Pro
195 200 205Phe Asn Leu Glu Leu Arg Leu Leu Gly Phe Phe Lys His Gln Lys Ser
210 215 220Leu Glu Ser Leu Arg Tyr Pro Lys Lys Thr Ile Val Leu Phe Ser Lys225 230 235 240Ala Lys Glu Cys His Lys Ser Phe Leu Asn Ile His Asn Lys Thr Glu
245 250 255Leu Lys Phe Leu Leu Lys Asn Tyr Asp Leu Glu Pro Phe Asn Leu Ala
260 265 270Leu Asp Phe Tyr Ala Leu Lys Asn Pro Lys His Ala Leu Lys Ile Lys
275 280 285Gly Leu Leu Lys Glu Ile Phe Asp Ser Asn Glu Pro Phe Lys Lys Glu
290 295 300His Leu Ala Leu Lys Gly Gly Ala Leu Gln Ser Leu Gly Tyr Gln His305 310 315 320Gln Lys Ile Gly Glu Ile Leu Asn Ala Cys Leu Asp Leu Val Ile Ala
325 330 335Asn Pro Lys Asn Asn Ala Leu Glu Trp Leu Ile Glu Trp Val Lys Gly
340 345 350His Tyr Leu Pro Asn Asp Thr Ile Asn Leu Ser Pro Ile Gly Arg Arg
355 360 365Asn
(2) Sequence 781 data:
(i) sequence characteristics:
(A) length: 360bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...340
(D) Other information:
(xi) Description of the sequence: and a sequence 781: TTTTCCCCTA TATCCAAAGC CATCATCAAG AAGTTTTAAG GCTCAAAGC ATG ATT TTT 58
Met Ile Phe
1TCC ACT CTT ATT AAT GCG ATA GCG GTG ATT TTA AGC TCG CTC ATT ACG 106Ser Thr Leu Ile Asn Ala Ile Ala Val Ile Leu Ser Ser Leu Ile Thr
5 10 15ATT TAT ATG TGG ATA GTA ATC ATT TAT TCG CTT ATC AGT TTC GTG CAG 154Ile Tyr Met Trp Ile Val Ile Ile Tyr Ser Leu Ile Ser Phe Val Gln20 25 30 35CCT AAC CCC AAT AAC CCC ATC ATG CAA ATT CTC GCT CGC TTG TGT GAG 202Pro Asn Pro Asn Asn Pro Ile Met Gln Ile Leu Ala Arg Leu Cys Glu
40 45 50CCG GTG TTT TAT TTT TTA CGC TCT AGA TTC AAG CTG GTG TTT AAC GGG 250Pro Val Phe Tyr Phe Leu Arg Ser Arg Phe Lys Leu Val Phe Asn Gly
55 60 65TTG GAT TTC TCT CCT TTA GTG GTG GTC ATT GTT TTG AAA TTC TTG GAT 298Leu Asp Phe Ser Pro Leu Val Val Val Ile Val Leu Lys Phe Leu Asp
70 75 80CTC ACG CTC ATT CAG TGG CTT TTC ATG CTC GCT AAA AAC CTT TAAAGAAAA 349Leu Thr Leu Ile Gln Trp Leu Phe Met Leu Ala Lys Asn Leu
85 90 95TCATGCGTTT T 360
(2) Sequence 782 material:
(i) sequence characteristics:
(A) length: 97 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 782: met Ile Phe Ser Thr Leu Ile Asn Ala Ile Ala Val Ile Leu Ser Ser 151015 Leu Ile Thr Ile Tyr Met Trp Ile Val Ile Ile Tyr Ser Leu Ile Ser
20 25 30Phe Val Gln Pro Asn Pro Asn Asn Pro Ile Met Gln Ile Leu Ala Arg
35 40 45Leu Cys Glu Pro Val Phe Tyr Phe Leu Arg Ser Arg Phe Lys Leu Val
50 55 60Phe Asn Gly Leu Asp Phe Ser Pro Leu Val Val Val Ile Val Leu Lys65 70 75 80Phe Leu Asp Leu Thr Leu Ile Gln Trp Leu Phe Met Leu Ala Lys Asn
85 90 95Leu
(2) Sequence 783 data:
(i) sequence characteristics:
(A) length: 1740bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 22...1701
(D) Other information:
(xi) Description of the sequence: sequence 783: TAAAAACCTT TAAAGAAAAT C ATG CGT TIT TTT ACC TTG TTT TIT ATC GGT 51
Met Arg Phe Phe Thr Leu Phe Phe Ile Gly
1 5 10ATG CTT GGC GTT GGT TTT TCT CAA ACC GAG TTA AAT TTA AAA GAT TTA 99Met Leu Gly Val Gly Phe Ser Gln Thr Glu Leu Asn Leu Lys Asp Leu
15 20 25GAA AAA AAG CCC GCC GGG ATC GTT AGG GAT TAT TAT TTG TGG CGT TAT 147Glu Lys Lys Pro Ala Gly Ile Val Arg Asp Tyr Tyr Leu Trp Arg Tyr
30 35 40ATT AGC GAT AAA AAA ACC AGT TTA GAA AAC GCT AAA AAA GCC TAT GAA 195Ile Ser Asp Lys Lys Thr Ser Leu Glu Asn Ala Lys Lys Ala Tyr Glu
45 50 55TTG ACT CAA AAT AAA AAC AAC GCC CTA CAA AAG GCC ATG CAA GAA AAA 243Leu Thr Gln Asn Lys Asn Asn Ala Leu Gln Lys Ala Met Gln Glu Lys
60 65 70GGC TCA GAC AAT GCA GAA AAA AAC CCT GAT GTT AAA TTG CCT GAA GAT 291Gly Ser Asp Asn Ala Glu Lys Asn Pro Asp Val Lys Leu Pro Glu Asp75 80 85 90ATT TAT TGC AAG CAA ACG GCT TTA GAA AGC ATG CTA GAA ACA ACA GAC 339Ile Tyr Cys Lys Gln Thr Ala Leu Glu Ser Met Leu Glu Thr Thr Asp
95 100 105ACT TTC CAA GCA AGC TGC ATC GCT ATC GCT TTA AAA TCA AAG ATC AGA 387Thr Phe Gln Ala Ser Cys Ile Ala Ile Ala Leu Lys Ser Lys Ile Arg
110 115 120GAT TTT GAT AAA ATC CCT ATT GAA ACC CTT AAG CCC TTA CAA ATT AAA 435Asp Phe Asp Lys Ile Pro Ile Glu Thr Leu Lys Pro Leu Gln Ile Lys
125 130 135ATC AAA GAG GCT TAC CCC GTT CTT TAT GAA GAA TTA GAA ATT TTG CAA 483Ile Lys Glu Ala Tyr Pro Val Leu Tyr Glu Glu Leu Glu Ile Leu Gln
140 145 150AGT AAG CAT GTG AGC GCT TCT TTG TTT AAG GCT AAC GCG CAA GTG TTT 531Ser Lys His Val Ser Ala Ser Leu Phe Lys Ala Asn Ala Gln Val Phe155 160 165 170AGC GCG CTT TTC AAT CAT TTG AGT TAT GAA AAA AAG CTC CAA ATT TTT 579Ser Ala Leu Phe Asn His Leu Ser Tyr Glu Lys Lys Leu Gln Ile Phe
175 180 185GAA AAG CAT ATC CCC ATT AAA GAG TTA AAC CGT CTT TTA GAC GAA AAT 627Glu Lys His Ile Pro Ile Lys Glu Leu Asn Arg Leu Leu Asp Glu Asn
190 195 200TAT CCG GCG TTT AAC CGC TTG ATC TAT CAG GTT ATT TTA GAT CCT AAA 675Tyr Pro Ala Phe Asn Arg Leu Ile Tyr Gln Val Ile Leu Asp Pro Lys
205 210 215TTG GAT CAT TTT AAA GAC GCT CTC ACT AAA AGT AAC GCT ACC CAC AGC 723Leu Asp His Phe Lys Asp Ala Leu Thr Lys Ser Asn Ala Thr His Ser
220 225 230AAC GCG CAA ACC TTT TTT ATT CTA GGG ATT AAT GAA ATC TTG CGC AAA 771Asn Ala Gln Thr Phe Phe Ile Leu Gly Ile Asn Glu Ile Leu Arg Lys235 240 245 250AAA CCC TCT AAA GCG CTC AAG TAT TTT GAA CGA TCA GAA GCG GTT GTC 819Lys Pro Ser Lys Ala Leu Lys Tyr Phe Glu Arg Ser Glu Ala Val Val
255 260 265AAA GAC GAT GAT TTT TCA AAA GAC AGA GCG ATT TTT TGG CAG TAT TTA 867Lys Asp Asp Asp Phe Ser Lys Asp Arg Ala Ile Phe Trp Gln Tyr Leu
270 275 280GTT TCT AAA AAG AAA AAA ACT TTA GAA CGC CTT TCA CAA AGC CCA GCT 915Val Ser Lys Lys Lys Lys Thr Leu Glu Arg Leu Ser Gln Ser Pro Ala
285 290 295TTA AAT CTC TAT AGT CTT TAT GCG AGC CGC AAA CTC AAA ACC ACG CCC 963Leu Asn Leu Tyr Ser Leu Tyr Ala Ser Arg Lys Leu Lys Thr Thr Pro
300 305 310AGT TAC CGC ATC ATT TCA CGC ATC CAG AAT TTA AGC CAA GAA GAT CCT 1011Ser Tyr Arg Ile Ile Ser Arg Ile Gln Asn Leu Ser Gln Glu Asp Pro315 320 325 330CCT TTT AAC ACT TAT GAC CCT TTT TCG TGG CAA ATT TTT AAG GAA AAA 1059Pro Phe Asn Thr Tyr Asp Pro Phe Ser Trp Gln Ile Phe Lys Glu Lys
335 340 345ACC TTG AGT TTG AAA GAT GAG GGC GCG TTT AAT GCG ATG CTA AAA AGC 1107Thr Leu Ser Leu Lys Asp Glu Gly Ala Phe Asn Ala Met Leu Lys Ser
350 355 360CTG TAT TAT GAA AAA AGC GCT CCT GAA TTG ACC TAT CTT TTA AGC CAA 1155Leu Tyr Tyr Glu Lys Ser Ala Pro Glu Leu Thr Tyr Leu Leu Ser Gln
365 370 375CGC AAT AAA GAC AAG ATT TAT TAT TAT TTA TCC CCT TAT GAG GGC ATT 1203Arg Asn Lys Asp Lys Ile Tyr Tyr Tyr Leu Ser Pro Tyr Glu Gly Ile
380 385 390ATT GAA TGG CAA AAT ACT GAT GAA AAG GCT ATG GCG TAT GCG ATC GCT 1251Ile Glu Trp Gln Asn Thr Asp Glu Lys Ala Met Ala Tyr Ala Ile Ala395 400 405410AGG CAA GAA AGC TTT TTG CTC CCG GCA GTC ATT TCG CGC TCG TTC GCT 1299Arg Gln Glu Ser Phe Leu Leu Pro Ala Val Ile Ser Arg Ser Phe Ala
415 420 425CTG GGG CTT ATG CAA ATC ATG CCC TTT AAT GTA GGG CCT TTC GCT AAA 1347Leu Gly Leu Met Gln Ile Met Pro Phe Asn Val Gly Pro Phe Ala Lys
430 435 440AGC CTT GGC ATG GAT AAC ATT GAT CTA AAC GAC ATG TTT AAC CCC AAC 1395Ser Leu Gly Met Asp Asn Ile Asp Leu Asn Asp Met Phe Asn Pro Asn
445 450 455ATC GCT CTC AAA TTT GGC AAT TAT TAC TTG AAC CAT TTG AAA AAA GAA 1443Ile Ala Leu Lys Phe Gly Asn Tyr Tyr Leu Asn His Leu Lys Lys Glu
460 465 470TTC AAC CAC CCC CTT TTT GTC GCC TAC GCT TAT AAC GCT GGG CCT GGG 1491Phe Asn His Pro Leu Phe Val Ala Tyr Ala Tyr Asn Ala Gly Pro Gly475 480 485 490TTT TTA AGG AGG TGG TTA GAA AGT TCC AAA CGA TTT AAA GAA AAA AAT 1539Phe Leu Arg Arg Trp Leu Glu Ser Ser Lys Arg Phe Lys Glu Lys Asn
495 500 505CAT TTT GAG CCA TGG CTT AGC ATG GAG CTT ATG CCT TAT AGC GAG ACT 1587His Phe Glu Pro Trp Leu Ser Met Glu Leu Met Pro Tyr Ser Glu Thr
510 515 520CGC ATG TAT GGC TTT AGG GTC ATG CTC AAT TAC TTG ATT TAT CAA GAA 1635Arg Met Tyr Gly Phe Arg Val Met Leu Asn Tyr Leu Ile Tyr Gln Glu
525 530 535ATT TTT GGG AAT TTC ATC CCT ATT GAT GGA TTT TTA GAA CAA ACT CTT 1683Ile Phe Gly Asn Phe Ile Pro Ile Asp Gly Phe Leu Glu Gln Thr Leu
540 545 550AAC TCA AAG GAC AAA CCA TGATTAAAAA ATGCCTTTTTCCTGCTGCGG GCTATGGC 1739Asn Ser Lys Asp Lys Pro555 560A 1740
(2) Sequence 784 data:
(i) sequence characteristics:
(A) length: 560 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 784: met Arg Phe Phe Thr Leu Phe Phe Ile Gly Met Leu Gly Val Gly Phe 151015 Ser Gln Thr Glu Leu Asn Leu Lys Asp Leu Glu Lys Lys Pro Ala Gly
20 25 30Ile Val Arg Asp Tyr Tyr Leu Trp Arg Tyr Ile Ser Asp Lys Lys Thr
35 40 45Ser Leu Glu Asn Ala Lys Lys Ala Tyr Glu Leu Thr Gln Asn Lys Asn
50 55 60Asn Ala Leu Gln Lys Ala Met Gln Glu Lys Gly Ser Asp Asn Ala Glu65 70 75 80Lys Asn Pro Asp Val Lys Leu Pro Glu Asp Ile Tyr Cys Lys Gln Thr
85 90 95Ala Leu Glu Ser Met Leu Glu Thr Thr Asp Thr Phe Gln Ala Ser Cys
100 105 110Ile Ala Ile Ala Leu Lys Ser Lys Ile Arg Asp Phe Asp Lys Ile Pro
115 120 125Ile Glu Thr Leu Lys Pro Leu Gln Ile Lys Ile Lys Glu Ala Tyr Pro
130 135 140Val Leu Tyr Glu Glu Leu Glu Ile Leu Gln Ser Lys His Val Ser Ala145 150155 160Ser Leu Phe Lys Ala Asn Ala Gln Val Phe Ser Ala Leu Phe Asn His
165 170 175Leu Ser Tyr Glu Lys Lys Leu Gln Ile Phe Glu Lys His Ile Pro Ile
180 185 190Lys Glu Leu Asn Arg Leu Leu Asp Glu Asn Tyr Pro Ala Phe Asn Arg
195 200 205Leu Ile Tyr Gln Val Ile Leu Asp Pro Lys Leu Asp His Phe Lys Asp
210 215 220Ala Leu Thr Lys Ser Asn Ala Thr His Ser Asn Ala Gln Thr Phe Phe225 230 235 240Ile Leu Gly Ile Asn Glu Ile Leu Arg Lys Lys Pro Ser Lys Ala Leu
245 250 255Lys Tyr Phe Glu Arg Ser Glu Ala Val Val Lys Asp Asp Asp Phe Ser
260 265 270Lys Asp Arg Ala Ile Phe Trp Gln Tyr Leu Val Ser Lys Lys Lys Lys
275 280 285Thr Leu Glu Arg Leu Ser Gln Ser Pro Ala Leu Asn Leu Tyr Ser Leu
290 295 300Tyr Ala Ser Arg Lys Leu Lys Thr Thr Pro Ser Tyr Arg Ile Ile Ser305 310 315 320Arg Ile Gln Asn Leu Ser Gln Glu Asp Pro Pro Phe Asn Thr Tyr Asp
325 330 335Pro Phe Ser Trp Gln Ile Phe Lys Glu Lys Thr Leu Ser Leu Lys Asp
340 345 350Glu Gly Ala Phe Asn Ala Met Leu Lys Ser Leu Tyr Tyr Glu Lys Ser
355 360 365Ala Pro Glu Leu Thr Tyr Leu Leu Ser Gln Arg Asn Lys Asp Lys Ile
370375 380Tyr Tyr Tyr Leu Ser Pro Tyr Glu Gly Ile Ile Glu Trp Gln Asn Thr385 390 395 400Asp Glu Lys Ala Met Ala Tyr Ala Ile Ala Arg Gln Glu Ser Phe Leu
405 410 415Leu Pro Ala Val Ile Ser Arg Ser Phe Ala Leu Gly Leu Met Gln Ile
420 425 430Met Pro Phe Asn Val Gly Pro Phe Ala Lys Ser Leu Gly Met Asp Asn
435 440 445Ile Asp Leu Asn Asp Met Phe Asn Pro Asn Ile Ala Leu Lys Phe Gly
450 455 460Asn Tyr Tyr Leu Asn His Leu Lys Lys Glu Phe Asn His Pro Leu Phe465 470 475 480Val Ala Tyr Ala Tyr Asn Ala Gly Pro Gly Phe Leu Arg Arg Trp Leu
485 490 495Glu Ser Ser Lys Arg Phe Lys Glu Lys Asn His Phe Glu Pro Trp Leu
500 505 510Ser Met Glu Leu Met Pro Tyr Ser Glu Thr Arg Met Tyr Gly Phe Arg
515 520 525Val Met Leu Asn Tyr Leu Ile Tyr Gln Glu Ile Phe Gly Asn Phe Ile
530 535 540Pro Ile Asp Gly Phe Leu Glu Gln Thr Leu Asn Ser Lys Asp Lys Pro545 550 555 560
(2) Sequence 785 data:
(i) sequence characteristics:
(A) length: 770bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...738
(D) Other information:
(xi) Description of the sequence: sequence 785: TAAAAAGAAG GACAA ATG ATG CCA TTT GAA GCT GTA ATC GGG CTA GAA GTC 51
Met Met Pro Phe Glu Ala Val Ile Gly Leu Glu Val
1 5 10CAT GTC CAA CTC AAC ACC AAA ACC AAA ATC TTT TGC TCT TGC TCT ACA 99His Val Gln Leu Asn Thr Lys Thr Lys Ile Phe Cys Ser Cys Ser Thr
15 20 25AGC TTT GGA GAA TCC CCT AAT TCT AAC ACC TGC CCT GTG TGT TTG GGT 147Ser Phe Gly Glu Ser Pro Asn Ser Asn Thr Cys Pro Val Cys Leu Gly
30 35 40TTA CCG GGA GCT TTG CCG GTA TTG AAT AAA GAA GTG GTT AAA AAA GCC 195Leu Pro Gly Ala Leu Pro Val Leu Asn Lys Glu Val Val Lys Lys Ala45 50 55 60ATC CAA TTA GGC ACA GCC ATT GAA GCC AAT ATC AAC CAA TAT TCT ATT 243Ile Gln Leu Gly Thr Ala Ile Glu Ala Asn Ile Asn Gln Tyr Ser Ile
65 70 75TTT GCG AGG AAA AAT TAT TTT TAC CCT GAT TTG CCT AAG GCT TAT CAA 291Phe Ala Arg Lys Asn Tyr Phe Tyr Pro Asp Leu Pro Lys Ala Tyr Gln
80 85 90ATT TCG CAG TTT GAA GTC CCT ATT GTG AGC GAT GGG AAA TTA GAG ATT 339Ile Ser Gln Phe Glu Val Pro Ile Val Ser Asp Gly Lys Leu Glu Ile
95 100 105GAC ACT AAA GAG GGT GCA AAA ATC GTG CGT ATT GAA AGG GCC CAC ATG 387Asp Thr Lys Glu Gly Ala Lys Ile Val Arg Ile Glu Arg Ala His Met
110 115 120GAA GAA GAC GCC GGT AAA AAT ATC CAT GAG GGC AGT TAT TCT TTA GTG 435Glu Glu Asp Ala Gly Lys Asn Ile His Glu Gly Ser Tyr Ser Leu Val125 130 135 140GAT TTG AAC CGC GCT TGC ACC CCT TTA TTA GAA ATT GTC AGT AAG CCG 483Asp Leu Asn Arg Ala Cys Thr Pro Leu Leu Glu Ile Val Ser Lys Pro
145 150 155GAC ATG CGA AAT AGT GAA GAA GCT ATA GCG TAT TTG AAA AAG CTC CAT 531Asp Met Arg Asn Ser Glu Glu Ala Ile Ala Tyr Leu Lys Lys Leu His
160 165 170GCT ATC GTG CGT TTT ATA GGG ATT TCT GAT GCG AAC ATG CAA GAG GGG 579Ala Ile Val Arg Phe Ile Gly Ile Ser Asp Ala Asn Met Gln Glu Gly
175 180 185AAT TTC AGG TGC GAT GCG AAC GTG TCC ATT AGA CCC AAA GGC GAT GAA 627Asn Phe Arg Cys Asp Ala Asn Val Ser Ile Arg Pro Lys Gly Asp Glu
190 195 200AAG CTT TAT ACG AGA GTA GAG ATT AAA AAT CTA AAT AGC TTT AGA TTC 675Lys Leu Tyr Thr Arg Val Glu Ile Lys Asn Leu Asn Ser Phe Arg Phe205 210 215 220ATT GCT AAA GCG ATT GAA TAC GAG ATA GAG CGC CAA AGC GCG GAC GTG 723Ile Ala Lys Ala Ile Glu Tyr Glu Ile Glu Arg Gln Ser Ala Asp Val
225 230 235GGA GAA CGG GCG CTA TAATGAAGAG GTGGTTCAAG AAACGCGCCT TT 770Gly Glu Arg Ala Leu
240
(2) Sequence 786 data:
(i) sequence characteristics:
(A) length: 241 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 786: met Met Pro Phe Glu Ala Val Ile Gly Leu Glu Val His Val Gln Leu 151015 Asn Thr Lys Thr Lys Ile Phe Cys Ser Cys Ser Thr Ser Phe Gly Glu
20 25 30Ser Pro Asn Ser Asn Thr Cys Pro Val Cys Leu Gly Leu Pro Gly Ala
35 40 45Leu Pro Val Leu Asn Lys Glu Val Val Lys Lys Ala Ile Gln Leu Gly
50 55 60Thr Ala Ile Glu Ala Asn Ile Asn Gln Tyr Ser Ile Phe Ala Arg Lys65 70 75 80Asn Tyr Phe Tyr Pro Asp Leu Pro Lys Ala Tyr Gln Ile Ser Gln Phe
85 90 95Glu Val Pro Ile Val Ser Asp Gly Lys Leu Glu Ile Asp Thr Lys Glu
100 105 110Gly Ala Lys Ile Val Arg Ile Gln Arg Ala His Met Glu Glu Asp Ala
115 120 125Gly Lys Asn Ile His Glu Gly Ser Tyr Ser Leu Val Asp Leu Asn Arg
130 135 140Ala Cys Thr Pro Leu Leu Glu Tle Val Ser Lys Pro Asp Met Arg Asn145 150 155 160Ser Glu Glu Ala Ile Ala Tyr Leu Lys Lys Leu His Ala Ile Val Arg
165 170 175Phe Ile Gly Ile Ser Asp Ala Asn Met Gln Glu Gly Asn Phe Arg Cys
180 185 190Asp Ala Asn Val Ser Ile Arg Pro Lys Gly Asp Gln Lys Leu Tyr Thr
195 200 205Arg Val Glu Ile Lys Asn Leu Asn Ser Phe Arg Phe Ile Ala Lys Ala
210 215 220Ile Glu Tyr Glu Ile Glu Arg Gln Ser Ala Asp Val Gly Glu Arg Ala225 230 235 240Leu
(2) Sequence 787 data:
(i) sequence characteristics:
(A) length: 487bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...444
(D) Other information:
(xi) Description of the sequence: sequence 787: ATGGGAGTGG ATTGA ATG CAA GAA ATT GAA ATT TTT TGC GAT GGC TCT TCT 51
Met Gln Glu Ile Glu Ile Phe Cys Asp Gly Ser Ser
1 5 10TTA GGC AAT CCC GGG CCA GGC GGT TAT GCG GCG ATT TTA CGC TAT AAA 99Leu Gly Asn Pro Gly Pro Gly Gly Tyr Ala Ala Ile Leu Arg Tyr Lys
15 20 25GAT AAA GAA AAA ACC ATC AGT GGG GGC GAA GAA TTC ACC ACG AAT AAC 147Asp Lys Glu Lys Thr Ile Ser Gly Gly Glu Glu Phe Thr Thr Asn Asn
30 35 40CGC ATG GAA TTA AGA GCG CTC AAT GAA GCG TTA AAA ATT TTG AAA CGC 195Arg Met Glu Leu Arg Ala Leu Asn Glu Ala Leu Lys Ile Leu Lys Arg45 50 55 60CCA TGC CGTATC ACG CTT TAT AGC GAT TCG CAA TAC GTG TGC CAA GCG 243Pro Cys Arg Ile Thr Leu Tyr Ser Asp Ser Gln Tyr Val Cys Gln Ala
65 70 75ATC AAT GTG TGG CTA GCT AAC TGG CAA AAA AAG AAT TTT TCT AAA GTT 291Ile Asn Val Trp Leu Ala Asn Trp Gln Lys Lys Asn Phe Ser Lys Val
80 85 90AAA AAT GTG GAT TTA TGG AAA GAA TTT TTA GAA GTC TCT AAA GGG CAT 339Lys Asn Val Asp Leu Trp Lys Glu Phe Leu Glu Val Ser Lys Gly His
95 100 105TCT ATT GTG GCT GTT TGG ATC AAG GGG CAT AAC GGG CAT GCC GAG AAT 387Ser Ile Val Ala Val Trp Ile Lys Gly His Asn Gly His Ala Glu Asn
110 115 120GAA CGA TGC GAT AGC CTC GCT AAA TTA GAG GCG CAA AAA CGG GTC AAA 435Glu Arg Cys Asp Ser Leu Ala Lys Leu Glu Ala Gln Lys Arg Val Lys125 130 135 140ACG ACC ACT TAAAGGGAAA AATGATGAAA AACAAACGCT CTCAAAACAG CCC 487Thr Thr Thr
(2) Sequence 788 data:
(i) sequence characteristics:
(A) length: 143 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 788: met Gln Glu Ile Glu Ile Phe Cys Asp Gly Ser Ser Leu Gly Asn Pro 151015 Gly Pro Gly Gly Tyr Ala Ala Ile Leu Arg Tyr Lys Asp Lys Glu Lys
20 25 30Thr Ile Ser Gly Gly Glu Glu Phe Thr Thr Asn Asn Arg Met Glu Leu
3540 45Arg Ala Leu Asn Glu Ala Leu Lys Ile Leu Lys Arg Pro Cys Arg Ile
50 55 60Thr Leu Tyr Ser Asp Ser Gln Tyr Val Cys Gln Ala Ile Asn Val Trp65 70 75 80Leu Ala Asn Trp Gln Lys Lys Asn Phe Ser Lys Val Lys Asn Val Asp
85 90 95Leu Trp Lys Glu Phe Leu Glu Val Ser Lys Gly His Ser Ile Val Ala
100 105 110Val Trp Ile Lys Gly His Asn Gly His Ala Glu Asn Glu Arg Cys Asp
115 120 125Ser Leu Ala Lys Leu Glu Ala Gln Lys Arg Val Lys Thr Thr Thr
130 135 140
(2) Sequence 789 data:
(i) sequence characteristics:
(A) length: 1217bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 48...1181
(D) Other information:
(xi) Description of the sequence: sequence 789: ATGTATGCGA CCGCTAAAGG CAAAAGCAAA AAAGAAGCCG AACAGCA ATG CGC TTA 56
Met Arg Leu
1TCA AGC GCT TCA AAA ACT GAA GGA AGC CAA ATG AAC ACT TTG GGG CGT 104Ser Ser Ala Ser Lys Thr Glu Gly Ser Gln Met Asn Thr Leu Gly Arg
5 10 15TTT TTA AGG CTC ACG ACT TTT GGG GAA TCG CAT GGG GAT GTG ATA GGG 152Phe Leu Arg Leu Thr Thr Phe Gly Glu Ser His Gly Asp Val Ile Gly20 25 30 35GGG GTA TTA GAC GGC ATG CCT AGC GGG ATT AAA ATA GAC TAT GCG CTA 200Gly Val Leu Asp Gly Met Pro Ser Gly Ile Lys Ile Asp Tyr Ala Leu
40 45 50TTA GAA AAT GAA ATG AAG CGC CGC CAA GGG GGG AGG AAC GTT TTC ATT 248Leu Glu Asn Glu Met Lys Arg Arg Gln Gly Gly Arg Asn Val Phe Ile
55 60 65ACG CCA CGA AAA GAA GAC GAT AAA GTG GAA ATA ACA AGC GGG GTT TTT 296Thr Pro Arg Lys Glu Asp Asp Lys Val Glu Ile Thr Ser Gly Val Phe
70 75 80GAA GAT TTT AGC ACA GGG ACT CCT ATA GGG TTT TTA ATC CAC AAC CAA 344Glu Asp Phe Ser Thr Gly Thr Pro Ile Gly Phe Leu Ile His Asn Gln
85 90 95AGG GCT AGG AGC AAG GAT TAC GAT AAC ATT AAA AAC CTT TTT AGG CCT 392Arg Ala Arg Ser Lys Asp Tyr Asp Asn Ile Lys Asn Leu Phe Arg Pro100 105 110 115AGC CAT GCG GAT TTC ACT TAT TTT CAT AAA TAC GGC ATT AGG GAT TTT 440Ser His Ala Asp Phe Thr Tyr Phe His Lys Tyr Gly Ile Arg Asp Phe
120 125 130AGG GGT GGG GGG AGG AGT TCG GCC AGA GAG AGT GCT ATA AGA GTG GCT 488Arg Gly Gly Gly Arg Ser Ser Ala Arg Glu Ser Ala Ile Arg Val Ala
135 140 145GCT GGG GCG TTT GCT AAA ATG CTT TTA AGA GAA ATC GGT ATT GTT TGT 536Ala Gly Ala Phe Ala Lys Met Leu Leu Arg Glu Ile Gly Ile Val Cys
150 155 160GAA AGC GGG ATT ATA GAA ATT GGG GGT ATT AAA GCC AAA AAT TAT GAT 584Glu Ser Gly Ile Ile Glu Ile Gly Gly Ile Lys Ala Lys Asn Tyr Asp
165 170 175TTT AAT CAC GCC TTA AAA AGC GAG ATT TTT GCC CTA GAT GAA GAA CAA 632Phe Asn His Ala Leu Lys Ser Glu Ile Phe Ala Leu Asp Glu Glu Gln180 185 190 195GAA GAA GCG CAA AAA ACA GCC ATT CAA AAC GCT ATC AAA AAC CAC GAT 680Glu Glu Ala Gln Lys Thr Ala Ile Gln Asn Ala Ile Lys Asn His Asp
200 205 210AGC ATA GGG GGT GTG GCT TTG ATT AGA GCG AGG AGC ATA AAA ACC AAT 728Ser Ile Gly Gly Val Ala Leu Ile Arg Ala Arg Ser Ile Lys Thr Asn
215 220 225CAA AAG CTC CCC ATT GGC TTA GGT CAA GGG CTA TAC GCT AAA TTA GAC 776Gln Lys Leu Pro Ile Gly Leu Gly Gln Gly Leu Tyr Ala Lys Leu Asp
230 235 240GCT AAA ATC GCT GAA GCG ATG ATG GGG CTT AAT GGG GTG AAA GCG GTT 824Ala Lys Ile Ala Glu Ala Met Met Gly Leu Asn Gly Val Lys Ala Val
245 250 255GAA ATA GGC AAG GGG GTA GAA AGC TCT TTA TTA AAA GGC TCA GAG TAT 872Glu Ile Gly Lys Gly Val Glu Ser Ser Leu Leu Lys Gly Ser Glu Tyr260 265 270 275AAT GAT TTA ATG GAT CAA AAG GGG TTT TTG AGC AAT CGT AGC GGA GGG 920Asn Asp Leu Met Asp Gln Lys Gly Phe Leu Ser Asn Arg Ser Gly Gly
280 285 290GTT TTA GGG GGC ATG AGC AAT GGG GAA GAA ATC ATT GTT AGA GTG CAT 968Val Leu Gly Gly Met Ser Asn Gly Glu Glu Ile Ile Val Arg Val His
295 300 305TTC AAA CCC ACG CCA AGC ATT TTC CAA CCT CAA CGA ACC ATA GAC ATT 1016Phe Lys Pro Thr Pro Ser Ile Phe Gln Pro Gln Arg Thr Ile Asp Ile
310 315 320AAT GGC AAT GAG TGC GAA TGC TTG TTA AAG GGC AGG CAT GAT CCT TGC 1064Asn Gly Asn Glu Cys Glu Cys Leu Leu Lys Gly Arg His Asp Pro Cys
325 330 335ATT GCG ATT AGA GGG AGC GTG GTG TGC GAG AGT TTG TTA GCG TTG GTG 1112Ile Ala Ile Arg Gly Ser Val Val Cys Glu Ser Leu Leu Ala Leu Val340 345 350 355TTG GCT GAT ATG GTA TTA CTC AAT TTG ACT TCA AAA ATA GAG TAT TTA 1160Leu Ala Asp Met Val Leu Leu Asn Leu Thr Ser Lys Ile Glu Tyr Leu
360 365 370AAA ACG ATT TAT AAT GAG AAT TAAACGAAAT TGGATACAAT CAGCTTAAAA AGGA 1215Lys Thr Ile Tyr Asn Glu Asn
375TA 1217
(2) Sequence 790 data:
(i) sequence characteristics:
(A) length: 378 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 790: met Arg Leu Ser Ser Ala Ser Lys Thr Glu Gly Ser Gln Met Asn Thr 151015 Leu Gly Arg Phe Leu Arg Leu Thr Thr Phe Gly Glu Ser His Gly Asp
20 25 30Val Ile Gly Gly Val Leu Asp Gly Met Pro Ser Gly Ile Lys Ile Asp
35 40 45Tyr Ala Leu Leu Glu Asn Glu Met Lys Arg Arg Gln Gly Gly Arg Asn
50 55 60Val Phe Ile Thr Pro Arg Lys Glu Asp Asp Lys Val Glu Ile Thr Ser65 70 75 80Gly Val Phe Glu Asp Phe Ser Thr Gly Thr Pro Ile Gly Phe Leu Ile
85 90 95His Asn Gln Arg Ala Arg Ser Lys Asp Tyr Asp Asn Ile Lys Asn Leu
100 105 110Phe Arg Pro Ser His Ala Asp Phe Thr Tyr Phe His Lys Tyr Gly Ile
115 120 125Arg Asp Phe Arg Gly Gly Gly Arg Ser Ser Ala Arg Glu Ser Ala Ile
130 135 140Arg Val Ala Ala Gly Ala Phe Ala Lys Met Leu Leu Arg Glu Ile Gly145 150 155 160Ile Val Cys Glu Ser Gly Ile Ile Glu Ile Gly Gly Ile Lys Ala Lys
165 170 175Asn Tyr Asp Phe Asn His Ala Leu Lys Ser Glu Ile Phe Ala Leu Asp
180 185 190Glu Glu Gln Glu Glu Ala Gln Lys Thr Ala Ile Gln Asn Ala Ile Lys
195 200 205Asn His Asp Ser Ile Gly Gly Val Ala Leu Ile Arg Ala Arg Ser Ile
210 215 220Lys Thr Asn Gln Lys Leu Pro Ile Gly Leu Gly Gln Gly Leu Tyr Ala225 230 235 240Lys Leu Asp Ala Lys Ile Ala Glu Ala Met Met Gly Leu Asn Gly Val
245 250 255Lys Ala Val Glu Ile Gly Lys Gly Val Glu Ser Ser Leu Leu Lys Gly
260 265 270Ser Glu Tyr Asn Asp Leu Met Asp Gln Lys Gly Phe Leu Ser Asn Arg
275 280 285Ser Gly Gly Val Leu Gly Gly Met Ser Asn Gly Glu Glu Ile Ile Val
290 295 300Arg Val His Phe Lys Pro Thr Pro Ser Ile Phe Gln Pro Gln Arg Thr305 310 315 320Ile Asp Ile Asn Gly Asn Glu Cys Glu Cys Leu Leu Lys Gly Arg His
325 330 335Asp Pro Cys Ile Ala Ile Arg Gly Ser Val Val Cys Glu Ser Leu Leu
340 345 350Ala Leu Val Leu Ala Asp Met Val Leu Leu Asn Leu Thr Ser Lys Ile
355 360 365Glu Tyr Leu Lys Thr Ile Tyr Asn Glu Asn
370 375
(2) Sequence 791 data:
(i) sequence characteristics:
(A) length: 588bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 20...535
(D) Other information:
(xi) Description of the sequence: sequence 791: TCATTGTGCC TGAAGCCAC ATG CGC TAC ATG CTC ATC AAC GAT TAT TAC AAG 52
Met Arg Tyr Met Leu Ile Asn Asp Tyr Tyr Lys
1 5 10GTG TTT TTG GGC GAA AAA GAT AAG GAT TTG TAT GTG AAG CGC TTG GAA 100Val Phe Leu Gly Glu Lys Asp Lys Asp Leu Tyr Val Lys Arg Leu Glu
15 20 25AAA ATC ACG CCT AAA ATC TAT CTG GCG AGC GTG TTT TTA GAG AAA CAC 148Lys Ile Thr Pro Lys Ile Tyr Leu Ala Ser Val Phe Leu Glu Lys His
30 35 40ACC CCT TTA AAA AGT CTT TTA GAA AAA ATC CCT AAG GGA AAA AAA GAG 196Thr Pro Leu Lys Ser Leu Leu Glu Lys Ile Pro Lys Gly Lys Lys Glu
45 50 55ACT ATC ACC TAT CAT AAC CCT TGT CAT GCC AAA AAA ACC CTA AAC GCT 244Thr Ile Thr Tyr His Asn Pro Cys His Ala Lys Lys Thr Leu Asn Ala60 65 70 75CAC AAA GAA GTG CGC AAC TTG CTC AAT TTG CAT TAT GAA ATT AAA GAA 292His Lys Glu Val Arg Asn Leu Leu Asn Leu His Tyr Glu Ile Lys Glu
80 85 90ATG CCG GAC AAT TGT TGC GGT TTT GGG GGG ATT ACG ATG CAA ACA CAA 340Met Pro Asp Asn Cys Cys Gly Phe Gly Gly Ile Thr Met Gln Thr Gln
95 100 105AAG GCG GGA TTT TCT TTA AAA GTG GGG CTT CTT AGG GCT AAA GAA ATC 388Lys Ala Gly Phe Ser Leu Lys Val Gly Leu Leu Arg Ala Lys Glu Ile
110 115 120ATA GAC ACC AAA GCT GCA ATT TTG AGC GCT GAA TGC GGG GCA TGC CAT 436Ile Asp Thr Lys Ala Ala Ile Leu Ser Ala Glu Cys Gly Ala Cys His
125 130 135ATG CAA TTA AAC AAC GCT TTA AAG TCT TTA GAC GAC CCT AAC ACT CCG 484Met Gln Leu Asn Asn Ala Leu Lys Ser Leu Asp Asp Pro Asn Thr Pro140 145 150 155CCA TTT TTG CAC CCT TTA GAA CTC ATC GCT AAA GCC TTA AAA AGC GCT 532Pro Phe Leu His Pro Leu Glu Leu Ile Ala Lys Ala Leu Lys Ser Ala
160 165 170GAA TAAAAAGCCT TTTTAACCCC ATTCTCCAAC ATCTTTTTAT ATAATACAGA GCT 588Glu
(2) Sequence 792 data:
(i) sequence characteristics:
(A) length: 172 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 792: met Arg Tyr Met Leu Ile Asn Asp Tyr Tyr Lys Val Phe Leu Gly Glu 151015 Lys Asp Lys Asp Leu Tyr Val Lys Arg Leu Glu Lys Ile Thr Pro Lys
20 25 30Ile Tyr Leu Ala Ser Val Phe Leu Glu Lys His Thr Pro Leu Lys Ser
35 40 45Leu Leu Glu Lys Ile Pro Lys Gly Lys Lys Glu Thr Ile Thr Tyr His
50 55 60Asn Pro Cys His Ala Lys Lys Thr Leu Asn Ala His Lys Glu Val Arg65 70 75 80Asn Leu Leu Asn Leu His Tyr Glu Ile Lys Glu Met Pro Asp Asn Cys
85 90 95Cys Gly Phe Gly Gly Ile Thr Met Gln Thr Gln Lys Ala Gly Phe Ser
100 105 110Leu Lys Val Gly Leu Leu Arg Ala Lys Glu Ile Ile Asp Thr Lys Ala
115 120 125Ala Ile Leu Ser Ala Glu Cys Gly Ala Cys His Met Gln Leu Asn Asn
130 135 140Ala Leu Lys Ser Leu Asp Asp Pro Asn Thr Pro Pro Phe Leu His Pro145150 155 160Leu Glu Leu Ile Ala Lys Ala Leu Lys Ser Ala Glu
165 170
(2) Sequence 793 data:
(i) sequence characteristics:
(A) length: 350bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 30...317
(D) Other information:
(xi) Description of the sequence: sequence 793: GGCGTTAAAG CTCTGTATTA TATAAAAAG ATG TTG GAG AAT GGG GTT AAA AAG 53
Met Leu Glu Asn Gly Val Lys Lys
1 5GCT TTT TAT TCA GCG CTT TTT AAG GCT TTA GCG ATG AGT TCT AAA GGG 101Ala Phe Tyr Ser Ala Leu Phe Lys Ala Leu Ala Met Ser Ser Lys Gly
10 15 20TGC AAA AAT GGC GGA GTG TTA GGG TCG TCT AAA GAC TTT AAA GCG TTG 149Cys Lys Asn Gly Gly Val Leu Gly Ser Ser Lys Asp Phe Lys Ala Leu25 30 35 40TTT AAT TGC ATA TGG CAT GCC CCG CAT TCA GCG CTC AAA ATT GCA GCT 197Phe Asn Cys Ile Trp His Ala Pro His Ser Ala Leu Lys Ile Ala Ala
45 50 55TTG GTG TCT ATG ATT TCT TTA GCC CTA AGA AGC CCC ACT TTT AAA GAA 245Leu Val Ser Met Ile Ser Leu Ala Leu Arg Ser Pro Thr Phe Lys Glu
60 65 70AAT CCC GCC TTT TGT GTT TGC ATC GTA ATC CCC CCA AAA CCG CAA CAA 293Asn Pro Ala Phe Cys Val Cys Ile Val Ile Pro Pro Lys Pro Gln Gln
75 80 85TTG TCC GGC ATT TCT TTA ATT TCA TAATGCAAAT TGAGCAACCT TTTGCATTCT 347Leu Ser Gly Ile Ser Leu Ile Ser
90 95TAC 350
(2) Sequence 794 data:
(i) sequence characteristics:
(A) Length: 96 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 794: met Leu Glu Asn Gly Val Lys Lys Ala Phe Tyr Ser Ala Leu Phe Lys 151015 Ala Leu Ala Met Ser Ser Lys Gly Cys Lys Asn Gly Gly Val Leu Gly
20 25 30Ser Ser Lys Asp Phe Lys Ala Leu Phe Asn Cys Ile Trp His Ala Pro
35 40 45His Ser Ala Leu Lys Ile Ala Ala Leu Val Ser Met Ile Ser Leu Ala
50 55 60Leu Arg Ser Pro Thr Phe Lys Glu Asn Pro Ala Phe Cys Val Cys Ile65 70 75 80Val Ile Pro Pro Lys Pro Gln Gln Leu Ser Gly Ile Ser Leu Ile Ser
85 90 95
(2) Sequence 795 data:
(i) sequence characteristics:
(A) length: 1800bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 69...1718
(D) Other information:
(xi) Description of the sequence: sequence 795: TCATCATCTC CACTTCTAAT TTAACCTCTA ACGCCCTTAA CGCAATTGAG CAAATCAGAA 60GCACAGGA ATG GGG ATT GAC ATT GAT GAA ATC ACT GAA GAG GAT TTT ATC 110
Met Gly Ile Asp Ile Asp Glu Ile Thr Glu Glu Asp Phe Ile
1 5 10TAT TCT CGC ATT GAT TGG GAA AAG TTT GAT CCC ACA AAA ACG CAA GAC 158Tyr Ser Arg Ile Asp Trp Glu Lys Phe Asp Pro Thr Lys Thr Gln Asp15 20 25 30GAA ATC CCC TTA TGC GAT AAG AAA AAG CCG CGC TCG CAT CAA ACA GAA 206Glu Ile Pro Leu Cys Asp Lys Lys Lys Pro Arg Ser His Gln Thr Glu
35 40 45GCC ATA AAC GCC ACT AAA GAG TAT TTT TCT GAC CCT AAA AAC GCT AGA 254Ala Ile Asn Ala Thr Lys Glu Tyr Phe Ser Asp Pro Lys Asn Ala Arg
50 55 60GGC AAG CTC ATT ATG GCA TGC GGG ACA GGC AAA ACC TAC ACT TCT TTA 302Gly Lys Leu Ile Met Ala Cys Gly Thr Gly Lys Thr Tyr Thr Ser Leu
65 70 75AAA ATC ATG GAA GCT TTA GAC TCT AAG ATC ACG CTT TTT CTA GCA CCC 350Lys Ile Met Glu Ala Leu Asp Ser Lys Ile Thr Leu Phe Leu Ala Pro
80 85 90AGC ATC GCT TTG CTTTCT CAA ACT TTT AGA GAA TAC GCG CAA GAA AAA 398Ser Ile Ala Leu Leu Ser Gln Thr Phe Arg Glu Tyr Ala Gln Glu Lys95 100 105 110AGT GAG CCG TTT TAC GCT TCT ATC GTG TGC AGC GAT GAT AAA GTC GGG 446Ser Glu Pro Phe Tyr Ala Ser Ile Val Cys Ser Asp Asp Lys Val Gly
115 120 125AAA AGT AAA GAC GAA GAC AAT GAT GAT ATT AAA TTT TCT GAG CTC CCT 494Lys Ser Lys Asp Glu Asp Asn Asp Asp Ile Lys Phe Ser Glu Leu Pro
130 135 140TTA AAG CCC TCC ACT CGC CTT GAA GAC ATT TTA AGC GTT CGA AAA AAA 542Leu Lys Pro Ser Thr Arg Leu Glu Asp Ile Leu Ser Val Arg Lys Lys
145 150 155GCG CAA AAA GAA AAC AAG CGC TTC ATT ATT TTT TCA ACC TAT CAA AGC 590Ala Gln Lys Glu Asn Lys Arg Phe Ile Ile Phe Ser Thr Tyr Gln Ser
160 165 170GCG TTG CGT ATT AAA GAA GCG CAA GAA GCG GGT TTG GGC GGA ATC GAT 638Ala Leu Arg Ile Lys Glu Ala Gln Glu Ala Gly Leu Gly Gly Ile Asp175 180 185 190CTT ATT ATT TGC GAT GAA GCC CAC AGA ACG GTA GGG GCT ATG TAT TCT 686Leu Ile Ile Cys Asp Glu Ala His Arg Thr Val Gly Ala Met Tyr Ser
195 200 205AGT AAT GAA AGG GAC GAT AAA AAC GCT TTC ACG CTT TGC CAT AGC GAT 734Ser Asn Glu Arg Asp Asp Lys Asn Ala Phe Thr Leu Cys His Ser Asp
210 215 220AAA AAT ATC AAA GCG AAA AAA CGC CTG TAT ATG ACC GCC ACG CCT AAA 782Lys Asn Ile Lys Ala Lys Lys Arg Leu Tyr Met Thr Ala Thr Pro Lys
225 230 235GTT TAT AGC GAA AGC TCC AAA GCT AAA GCC AAA GAG AGC GAT AAT GTT 830Val Tyr Ser Glu Ser SerLys Ala Lys Ala Lys Glu Ser Asp Asn Val
240 245 250ATC TAT TCT ATG GAC GAT GCA GAG ATT TTT GGC GAA GAA ATC TAT ACG 878Ile Tyr Ser Met Asp Asp Ala Glu Ile Phe Gly Glu Glu Ile Tyr Thr255 260 265 270CTC AAT TTT TCA AAA GCG ATC GCT TTG GAT CTC TTA ACC GAT TAT AAA 926Leu Asn Phe Ser Lys Ala Ile Ala Leu Asp Leu Leu Thr Asp Tyr Lys
275 280 285GTC ATC ATT TTA GCG GTG CGA AAA GAA AAT TTA AGC GGC GTT ACT AAC 974Val Ile Ile Leu Ala Val Arg Lys Glu Asn Leu Ser Gly Val Thr Asn
290 295 300AGC GTG AAT AAA AAG ATC AGC CAG CTC AAA GCC GAA GGC ACT AAA TTA 1022Ser Val Asn Lys Lys Ile Ser Gln Leu Lys Ala Glu Gly Thr Lys Leu
305 310 315GAT AAA AAG CTC ATC AAT AAC GAA TTT GTT TGT AAG ATC ATC GGC ACT 1070Asp Lys Lys Leu Ile Asn Asn Glu Phe Val Cys Lys Ile Ile Gly Thr
320 325 330CAT AAA GGG TTA GCC AAG CAG GAT TTA ATC GTT TTA AAC GAG AAA AAC 1118His Lys Gly Leu Ala Lys Gln Asp Leu Ile Val Leu Asn Glu Lys Asn335 340 345 350AAA GAA GAT CAC AAC TTG CAA AAC CAA TAC GAC ACC GCT CCC TCT CAA 1166Lys Glu Asp His Asn Leu Gln Asn Gln Tyr Asp Thr Ala Pro Ser Gln
355 360 365AGA GCC ATA AAC TTT TGT AAA AGC ATT AAC ACG AGC AAG AAC ATT AAA 1214Arg Ala Ile Asn Phe Cys Lys Ser Ile Asn Thr Ser Lys Asn Ile Lys
370 375 380GAC TCC TTT GAA ACG ATT ATG GAA TGC TAT GAT GAA GAG TTG AAG AAA 1262Asp Ser Phe Glu Thr Ile Met Glu Cys Tyr Asp Glu Glu Leu Lys Lys
385 390395AAG AGT TTT AAA AAC CTA AAA ATC AGC ATC GAT CAC ATT GAT GGC ACC 1310Lys Ser Phe Lys Asn Leu Lys Ile Ser Ile Asp His Ile Asp Gly Thr
400 405 410ATG AAT TGT AAG GAT AGG CTT GAA AAA TTA GAA GAG CTC AAT CAA TTT 1358Met Asn Cys Lys Asp Arg Leu Glu Lys Leu Glu Glu Leu Asn Gln Phe415 420 425 430GAG CCC AAC ACT TGC AAG GTT TTA AGC AAC GCC AGG TGT TTG AGC GAA 1406Glu Pro Asn Thr Cys Lys Val Leu Ser Asn Ala Arg Cys Leu Ser Glu
435 440 445GGG GTG GAT GTC CCA GCG TTA GAT AGC ATC GTC TTT TTT GAT GGC AAA 1454Gly Val Asp Val Pro Ala Leu Asp Ser Ile Val Phe Phe Asp Gly Lys
450 455 460AGC GCT ATG GTG GAT ATT ATC CAA GCG GTG GGT AGG GTG ATG CGA AAA 1502Ser Ala Met Val Asp Ile Ile Gln Ala Val Gly Arg Val Met Arg Lys
465 470 475GCC AAA CGC AAG AAA AGA GGC TAT ATC ATT TTG CCT ATC GCT TTA GAA 1550Ala Lys Arg Lys Lys Arg Gly Tyr Ile Ile Leu Pro Ile Ala Leu Glu
480 485 490GAG AGT GAA ATC CAA AAC CTG GAT GAA GCC GTC AAT AAC ACC AAT TTC 1598Glu Ser Glu Ile Gln Asn Leu Asp Glu Ala Val Asn Asn Thr Asn Phe495 500 505 510AAA AAC ATT TGG AAA GTG ATA AAA GCC TTA AGA AGC CAT GAC CCA AGC 1646Lys Asn Ile Trp Lys Val Ile Lys Ala Leu Arg Ser His Asp Pro Ser
515 520 525CTG GTT GAT GAA GCC ACT TTT AAA GAA AAA ATC AAA ATC TTT GGA AGC 1694Leu Val Asp Glu Ala Thr Phe Lys Glu Lys Ile Lys Ile Phe Gly Ser
530 535 540GAT GAT GGC AAC CAA TCA CAA CGA TGAAAAAACC CTTTTTGACG CTATCTTACT 1748Asp Asp Gly Asn Gln Ser Gln Arg
545 550GCAAGATCTA GCGGACGCTA TGTATAATGT CATGCCCACT AAATTAGGGG AC 1800
(2) Sequence 796 data:
(i) sequence characteristics:
(A) length: 550 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 796: met Gly Ile Asp Ile Asp Glu Ile Thr Glu Glu Asp Phe Ile Tyr Ser 151015 Arg Ile Asp Trp Glu Lys Phe Asp Pro Thr Lys Thr Gln Asp Glu Ile
20 25 30Pro Leu Cys Asp Lys Lys Lys Pro Arg Ser His Gln Thr Glu Ala Ile
35 40 45Asn Ala Thr Lys Glu Tyr Phe Ser Asp Pro Lys Asn Ala Arg Gly Lys
50 55 60Leu Ile Met Ala Cys Gly Thr Gly Lys Thr Tyr Thr Ser Leu Lys Ile65 70 75 80Met Glu Ala Leu Asp Ser Lys Ile Thr Leu Phe Leu Ala Pro Ser Ile
85 90 95Ala Leu Leu Ser Gln Thr Phe Arg Glu Tyr Ala Gln Glu Lys Ser Glu
100 105 110Pro Phe Tyr Ala Ser Ile Val Cys Ser Asp Asp Lys Val Gly Lys Ser
115 120 125Lys Asp Glu Asp Asn Asp Asp Ile Lys Phe Ser Glu Leu Pro Leu Lys
130 135 140Pro Ser Thr Arg Leu Glu Asp Ile Leu Ser Val Arg Lys Lys Ala Gln145 150 155 160Lys Glu Asn Lys Arg Phe Ile Ile Phe Ser Thr Tyr Gln Ser Ala Leu
165 170 175Arg Ile Lys Glu Ala Gln Glu Ala Gly Leu Gly Gly Ile Asp Leu Ile
180 185 190Ile Cys Asp Glu Ala His Arg Thr Val Gly Ala Met Tyr Ser Ser Asn
195 200 205Glu Arg Asp Asp Lys Asn Ala Phe Thr Leu Cys His Ser Asp Lys Asn
210 215 220Ile Lys Ala Lys Lys Arg Leu Tyr Met Thr Ala Thr Pro Lys Val Tyr225 230 235 240Ser Glu Ser Ser Lys Ala Lys Ala Lys Glu Ser Asp Asn Val Ile Tyr
245 250 255Ser Met Asp Asp Ala Glu Ile Phe Gly Glu Glu Ile Tyr Thr Leu Asn
260 265 270Phe Ser Lys Ala Ile Ala Leu Asp Leu Leu Thr Asp Tyr Lys Val Ile
275 280 285Ile Leu Ala Val Arg Lys Glu Asn Leu Ser Gly Val Thr Asn Ser Val
290 295 300Asn Lys Lys Ile Ser Gln Leu Lys Ala Glu Gly Thr Lys Leu Asp Lys305 310 315 320Lys Leu Ile Asn Asn Glu Phe Val Cys Lys Ile Ile Gly Thr His Lys
325 330 335Gly Leu Ala Lys Gln Asp Leu Ile Val Leu Asn Glu Lys Asn Lys Glu
340 345 350Asp His Asn Leu Gln Asn Gln Tyr Asp Thr Ala Pro Ser Gln Arg Ala
355 360 365Ile Asn Phe Cys Lys Ser Ile Asn Thr Ser Lys AsnIle Lys Asp Ser
370 375 380Phe Glu Thr Ile Met Glu Cys Tyr Asp Glu GIu Leu Lys Lys Lys Ser385 390 395 400Phe Lys Asn Leu Lys Ile Ser Ile Asp His Ile Asp Gly Thr Met Asn
405 410 415Cys Lys Asp Arg Leu Glu Lys Leu Glu Glu Leu Asn Gln Phe Glu Pro
420 425 430Asn Thr Cys Lys Val Leu Ser Asn Ala Arg Cys Leu Ser Glu Gly Val
435 440 445Asp Val Pro Ala Leu Asp Ser Ile Val Phe Phe Asp Gly Lys Ser Ala
450 455 460Met Val Asp Ile Ile Gln Ala Val Gly Arg Val Met Arg Lys Ala Lys465 470 475 480Arg Lys Lys Arg Gly Tyr Ile Ile Leu Pro Ile Ala Leu Glu Glu Ser
485 490 495Glu Ile Gln Asn Leu Asp Glu Ala Val Asn Asn Thr Asn Phe Lys Asn
500 505 510Ile Trp Lys Val Ile Lys Ala Leu Arg Ser His Asp Pro Ser Leu Val
515 520 525Asp Glu Ala Thr Phe Lys Glu Lys Ile Lys Ile Phe Gly Ser Asp Asp
530 535 540Gly Asn Gln Ser Gln Arg545 550
(2) Sequence 797 data:
(i) sequence characteristics:
(A) length: 2880bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...2814
(D) Other information:
(xi) Description of the sequence: sequence 797: AAGCCTTAAG AAGCC ATG ACC CAA GCC TGG TTG ATG AAG CCA CTT TTA AAG 51
Met Thr Gln Ala Trp Leu Met Lys Pro Leu Leu Lys
1 5 10AAA AAA TCA AAA TCT TTG GAA GCG ATG ATG GCA ACC AAT CAC AAC GAT 99Lys Lys Ser Lys Ser Leu Glu Ala Met Met Ala Thr Asn His Asn Asp
15 20 25GAA AAA ACC CTT TTT GAC GCT ATC TTA CTG CAA GAT CTA GCG GAC GCT 147Glu Lys Thr Leu Phe Asp Ala Ile Leu Leu Gln Asp Leu Ala Asp Ala
30 35 40ATG TAT AAT GTC ATG CCC ACT AAA TTA GGG GAC AGG AAT TAT TGG GAA 195Met Tyr Asn Val Met Pro Thr Lys Leu Gly Asp Arg Asn Tyr Trp Glu45 50 55 60AAT TTC ACT AAA AAA ACG GGC AAC ATC GCA AGG ACC TTG AAC AAC CGC 243Asn Phe Thr Lys Lys Thr Gly Asn Ile Ala Arg Thr Leu Asn Asn Arg
65 70 75CTA AAA ATT ATT TTT GAC AAA AAC CCT GAA TTT TTC CAC GGC TTT TTG 291Leu Lys Ile Ile Phe Asp Lys Asn Pro Glu Phe Phe His Gly Phe Leu
80 85 90GAT TCC TTA AGG GAA AAT ATC CAT CAA AAC ATT AAA GAA GAT GAA GCC 339Asp Ser Leu Arg Glu Asn Ile His Gln Asn Ile Lys Glu Asp Glu Ala
95 100 105TTA GAC ATG ATC ACT TCT CAC ATC ATC ACT AAG CCC ATT TTT GAT GCA 387Leu Asp Met Ile Thr Ser His Ile Ile Thr Lys Pro Ile Phe Asp Ala
110 115 120CTT TTT GGG GAC AAC ATC AAA AAC CCT ATC GCT AAA GCC TTG GAT AAA 435Leu Phe Gly Asp Asn Ile Lys Asn Pro Ile Ala Lys Ala Leu Asp Lys125 130 135 140ATG GTA GAA AAA CTC TCC ACT TTA GGA TTA GAA GGA GAA ACT AAA GAT 483Met Val Glu Lys Leu Ser Thr Leu Gly Leu Glu Gly Glu Thr Lys Asp
145 150 155CTG AAA AAC CTC TAT GAA AGC GTG AAA ACC GAA GCC TTG CAC GCC AAA 531Leu Lys Asn Leu Tyr Glu Ser Val Lys Thr Glu Ala Leu His Ala Lys
160 165 170AGC CAA AAA AGC CAA CAA GAA CTC ATT AAA AAC CTC TAC AAC ACT TTC 579Ser Gln Lys Ser Gln Gln Glu Leu Ile Lys Asn Leu Tyr Asn Thr Phe
175 180 185TTT AAA GAA GCC TTT AAA AAG CAA AGC GAA AAA CTA GGG ATC GTT TAT 627Phe Lys Glu Ala Phe Lys Lys Gln Ser Glu Lys Leu Gly Ile Val Tyr
190 195 200ACG CCC ATA GAG GTG GTG GAT TTC ATT TTA AGA GCC ACT AAC GGC ATT 675Thr Pro Ile Glu Val Val Asp Phe Ile Leu Arg Ala Thr Asn Gly Ile205 210 215 220TTG AAA AAG CAT TTC AAC ACG GAT TTT AAC GAT CAA AGC ATC ACG ATT 723Leu Lys Lys His Phe Asn Thr Asp Phe Asn Asp Gln Ser Ile Thr Ile
225 230 235TTT GAC CCA TTC ACC GGC ACC GGG AGT TTT ATC GCT CGT TTG CTT TCT 771Phe Asp Pro Phe Thr Gly Thr Gly Ser Phe Ile Ala Arg Leu Leu Ser
240 245 250AAA GAA AAC GCG CTC ATT AGC GAT GAA GCC TTA AAA GAG AAG TTT CAA 819Lys Glu Asn Ala Leu Ile Ser Asp Glu Ala Leu Lys Glu Lys Phe Gln
255 260265AAA AAT TTG TTC GCT TTT GAC ATC GTG CTT TTG TCT TAT TAT ATC GCT 867Lys Asn Leu Phe Ala Phe Asp Ile Val Leu Leu Ser Tyr Tyr Ile Ala
270 275 280TTA ATC AAT ATC ACC CAA GCC GCG CAA AAT AGG GAT GGC TCG TTA AAC 915Leu Ile Asn Ile Thr Gln Ala Ala Gln Asn Arg Asp Gly Ser Leu Asn285 290 295 300AAT TTC AAA AAC ATC GCG CTC ACG GAC AGC CTG GAT TAT TTA GAA GAA 963Asn Phe Lys Asn Ile Ala Leu Thr Asp Ser Leu Asp Tyr Leu Glu Glu
305 310 315AAA ACC AAT AAA GGG GTG CTC CCT TTA TAT GAG GAT TTG AAA GAA AAC 1011Lys Thr Asn Lys Gly Val Leu Pro Leu Tyr Glu Asp Leu Lys Glu Asn
320 325 330AAA GGC ATC AAA GAC ACT CTA GCC AAC CAA AAT ATT AGA GTC ATC ATC 1059Lys Gly Ile Lys Asp Thr Leu Ala Asn Gln Asn Ile Arg Val Ile Ile
335 340 345GGC AAC CCG CCT TAT TCA GCC GGC GCA AAG AGC CAA AAC GAT AAC AAC 1107Gly Asn Pro Pro Tyr Ser Ala Gly Ala Lys Ser Gln Asn Asp Asn Asn
350 355 360CAA AAC CTC TCA CAC CCA AAG CTT GAA AAA TTA GTT TAT GAA AAA TAC 1155Gln Asn Leu Ser His Pro Lys Leu Glu Lys Leu Val Tyr Glu Lys Tyr365 370 375 380GGA AAA AAT TCC ACA TCT AGA AGT GTG GGA AAA ACC ACA CGA GAC ACG 1203Gly Lys Asn Ser Thr Ser Arg Ser Val Gly Lys Thr Thr Arg Asp Thr
385 390 395CTC ATT CAA AGC ATC CGC ATG GCG AGC GAT GTT GTT AAA GAT AGG GGG 1251Leu Ile Gln Ser Ile Arg Met Ala Ser Asp Val Val Lys Asp Arg Gly
400 405 410GTG ATA GGC TTT GTG GTG AAC GGG GGT TTT ATT GAC TCT AAA AGC GCG 1299Val Ile Gly Phe Val Val Asn Gly Gly Phe Ile Asp Ser Lys Ser Ala
415 420 425GAT GGG TTC AGA AAA TGC GTG GCC AAA GAA TTT TCG CAT CTT TAT GTA 1347Asp Gly Phe Arg Lys Cys Val Ala Lys Glu Phe Ser His Leu Tyr Val
430 435 440TTG AAT TTG AGA GGC AAT CAG CGC ACT TCT GGG GAA GTG TCA AAA AAA 1395Leu Asn Leu Arg Gly Asn Gln Arg Thr Ser Gly Glu Val Ser Lys Lys445 450 455 460GAG GGA GGG AAA ATC TTT GAT AGC GGA TCG AGG GCG ACG GTA GCG ATT 1443Glu Gly Gly Lys Ile Phe Asp Ser Gly Ser Arg Ala Thr Val Ala Ile
465 470 475ATC TTT TTT GTG AAA GAT AAG AGC ACT CCT GAT AAT ACG ATT TTT TAT 1491Ile Phe Phe Val Lys Asp Lys Ser Thr Pro Asp Asn Thr Ile Phe Tyr
480 485 490TAT GAA GTG GAA GAT TAC TTG AAA AGA GAA GCC AAA CTC AAC TGG CTC 1539Tyr Glu Val Glu Asp Tyr Leu Lys Arg Glu Ala Lys Leu Asn Trp Leu
495 500 505GCC AAT TTT GAA AAT TTG GAT TTT GTG CCT TTT GAG AAA ATC ACC CCG 1587Ala Asn Phe Glu Asn Leu Asp Phe Val Pro Phe Glu Lys Ile Thr Pro
510 515 520AAT GAT AAA GGC GAT TGG ATC AAC CAA AGG AAT GAC GCT TTT GAA AAA 1635Asn Asp Lys Gly Asp Trp Ile Asn Gln Arg Asn Asp Ala Phe Glu Lys525 530 535 540CTC ATC CCT TTA AAA AGA GAC AAA ACA CTC CAA AAC GAC AGC GTT TTT 1683Leu Ile Pro Leu Lys Arg Asp Lys Thr Leu Gln Asn Asp Ser Val Phe
545 550 555GAC ATC AAT TCT CTT GGC GTG GTG AGC GGT CGT GAT CCT TGG GTG TAT 1731Asp Ile Asn Ser Leu Gly Val Val Ser Gly Arg Asp Pro Trp ValTyr
560 565 570AAC TTT TCT CCA AAC ATT TTA ACC CAA TCG GTG CAA AAA TGC ATT GAC 1779Asn Phe Ser Pro Asn Ile Leu Thr Gln Ser Val Gln Lys Cys Ile Asp
575 580 585ACT TAT AAC GCT GAT TTG AAG CGC TTC AAT GCG CGT TTT AGG GAA GCT 1827Thr Tyr Asn Ala Asp Leu Lys Arg Phe Asn Ala Arg Phe Arg Glu Ala
590 595 600TTC AAA CAA CGC GCT CAA AGC GTC AAA GCA GGC GAT CTT TAC AAA CAA 1875Phe Lys Gln Arg Ala Gln Ser Val Lys Ala Gly Asp Leu Tyr Lys Gln605 610 615 620CTT AAT GAT AAA GAA ATC ACC ACC GAT AAA ACG AAA ATC GCT TGG ACT 1923Leu Asn Asp Lys Glu Ile Thr Thr Asp Lys Thr Lys Ile Ala Trp Thr
625 630 635GAT GGT TTG AAA AAC AAA CTC ATT AAA AAT AAA TCT GCA AGA GAA AGC 1971Asp Gly Leu Lys Asn Lys Leu Ile Lys Asn Lys Ser Ala Arg Glu Ser
640 645 650AGT GAG GAG CGT GTA AGG TTG GCC TTG TAT CGC CCT TTT AAC AAA CAA 2019Ser Glu Glu Arg Val Arg Leu Ala Leu Tyr Arg Pro Phe Asn Lys Gln
655 660 665TGG CTT TAT TGG GAT AAG GAT TGG ATA AAC AGG CAA AGA GAA TTT TCA 2067Trp Leu Tyr Trp Asp Lys Asp Trp Ile Asn Arg Gln Arg Glu Phe Ser
670 675 680AAA ATT TTC CCG GAT AAA GAC GCT CAG AAT GTG GTG ATT AAT ACC GGT 2115Lys Ile Phe Pro Asp Lys Asp Ala Gln Asn Val Val Ile Asn Thr Gly685 690 695 700GTG GGA AAT GGT AAA GAT TTT AGC GCT TTG GTA AGC GAT TTT ATT TCT 2163Val Gly Asn Gly Lys Asp Phe Ser Ala Leu Val Ser Asp Phe Ile Ser
705 710715GAT TAT AGT TTG ATC TCA CCC AAT CAA GCT TAC CCC TTG TAT TAT TAC 2211Asp Tyr Ser Leu Ile Ser Pro Asn Gln Ala Tyr Pro Leu Tyr Tyr Tyr
720 725 730GAT GAT TTG GGG AAT CGC CAT TAC GCC ATC AGC GGC TAT TGC TTA AAC 2259Asp Asp Leu Gly Asn Arg His Tyr Ala Ile Ser Gly Tyr Cys Leu Asn
735 740 745CTC TTC AGG AGG CAT TAT GGG GAT AAT CTG ATC GCT GAA GAA GAG ATT 2307Leu Phe Arg Arg His Tyr Gly Asp Asn Leu Ile Ala Glu Glu Glu Ile
750 755 760TTT TAT TAC ATT TAT GCG ATT TTC CAC CAT AAA GGC TAT TTA GAA AAA 2355Phe Tyr Tyr Ile Tyr Ala Ile Phe His His Lys Gly Tyr Leu Glu Lys765 770 775 780TAC AAA AAT TCC CTC GCC AAA GAA GCG CCG CGC ATC GCT TTG AGC GAA 2403Tyr Lys Asn Ser Leu Ala Lys Glu Ala Pro Arg Ile Ala Leu Ser Glu
785 790 795GAT TTT AAA GAA CTC TCT GTG CTT GGC AAA GAA TTG GCC GAA TTG CAC 2451Asp Phe Lys Glu Leu Ser Val Leu Gly Lys Glu Leu Ala Glu Leu His
800 805 810CTG AAC TAT GAG AGT GGG GAA ATG CAT GAT AAT ATT AAA TAC ACC ACA 2499Leu Asn Tyr Glu Ser Gly Glu Met His Asp Asn Ile Lys Tyr Thr Thr
815 820 825CTG ATG AAC GCC GAA ATA GAG GGT TAT TAT GAT GTG GAT AAA ATG ACC 2547Leu Met Asn Ala Glu Ile Glu Gly Tyr Tyr Asp Val Asp Lys Met Thr
830 835 840AAA AAA GGG GAT TGC ATC ATC TAT AAC CAA AAC ATC GCT ATC ACT AAG 2595Lys Lys Gly Asp Cys Ile Ile Tyr Asn Gln Asn Ile Ala Ile Thr Lys845 850 855 860ATC CCT AAA AAA GCC TTT GAC TAT GTC ATT AAT GGC AAG AGC GCG ATT 2643Ile ProLys Lys Ala Phe Asp Tyr Val Ile Asn Gly Lys Ser Ala Ile
865 870 875GAC TGG GTG ATC GAA CGC TAT CAA AAA ACT ATG GAT AAA GAA AGC CTG 2691Asp Trp Val Ile Glu Arg Tyr Gln Lys Thr Met Asp Lys Glu Ser Leu
880 885 890ATT GAA AAC AAC CCG AAC GAT TAC GCC GGC GGA AAA TAC GTT TTT GAA 2739Ile Glu Asn Asn Pro Asn Asp Tyr Ala Gly Gly Lys Tyr Val Phe Glu
895 900 905CTC CTT TGT AGG GTC ATC ACA CTT TCG GTA AAA AGC GTG GAT TTG ATA 2787Leu Leu Cys Arg Val Ile Thr Leu Ser Val Lys Ser Val Asp Leu Ile
910 915 920GAA AAG ATC AGC GAA AAG AGG TTT GAG TGATTACATC GCTTGGGGGT GTGGAAT 2841Glu Lys Ile Ser Glu Lys Arg Phe Glu925 930ATTTTGAAAG GCAATGTCTT GCTTTCTTAA AAAATCCAC 2880
(2) Sequence 798 data:
(i) sequence characteristics:
(A) length: 933 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 798: met Thr Gln Ala Trp Leu Met Lys Pro Leu Leu Lys Lys Lys Ser Lys 151015 Ser Leu Glu Ala Met Met Ala Thr Asn His Asn Asp Glu Lys Thr Leu
20 25 30Phe Asp Ala Ile Leu Leu Gln Asp Leu Ala Asp Ala Met Tyr Asn Val
35 40 45Met Pro Thr Lys Leu Gly Asp Arg Asn Tyr Trp Glu Asn Phe Thr Lys
50 55 60Lys Thr Gly Asn Ile Ala Arg Thr Leu Asn Asn Arg Leu Lys Ile Ile65 70 75 80Phe Asp Lys Asn Pro Glu Phe Phe His Gly Phe Leu Asp Ser Leu Arg
85 90 95Glu Asn Ile His Gln Asn Ile Lys Glu Asp Glu Ala Leu Asp Met Ile
100 105 110Thr Ser His Ile Ile Thr Lys Pro Ile Phe Asp Ala Leu Phe Gly Asp
115 120 125Asn Ile Lys Asn Pro Ile Ala Lys Ala Leu Asp Lys Met Val Glu Lys
130 135 140Leu Ser Thr Leu Gly Leu Glu Gly Glu Thr Lys Asp Leu Lys Asn Leu145 150 155 160Tyr Glu Ser Val Lys Thr Glu Ala Leu His Ala Lys Ser Gln Lys Ser
165 170 175Gln Gln Glu Leu Ile Lys Asn Leu Tyr Asn Thr Phe Phe Lys Glu Ala
180 185 190Phe Lys Lys Gln Ser Glu Lys Leu Gly Ile Val Tyr Thr Pro Ile Glu
195 200 205Val Val Asp Phe Ile Leu Arg Ala Thr Asn Gly Ile Leu Lys Lys His
210 215 220Phe Asn Thr Asp Phe Asn Asp Gln Ser Ile Thr Ile Phe Asp Pro Phe225 230 235 240Thr Gly Thr Gly Ser Phe Ile Ala Arg Leu Leu Ser Lys Glu Asn Ala
245 250 255Leu Ile Ser Asp Glu Ala Leu Lys Glu Lys Phe Gln Lys Asn Leu Phe
260 265 270Ala Phe Asp Ile Val Leu Leu Ser Tyr Tyr Ile Ala Leu Ile Asn Ile
275280 285Thr Gln Ala Ala Gln Asn Arg Asp Gly Ser Leu Asn Asn Phe Lys Asn
290 295 300Ile Ala Leu Thr Asp Ser Leu Asp Tyr Leu Glu Glu Lys Thr Asn Lys305 310 315 320Gly Val Leu Pro Leu Tyr Glu Asp Leu Lys Glu Asn Lys Gly Ile Lys
325 330 335Asp Thr Leu Ala Asn Gln Asn Ile Arg Val Ile Ile Gly Asn Pro Pro
340 345 350Tyr Ser Ala Gly Ala Lys Ser Gln Asn Asp Asn Asn Gln Asn Leu Ser
355 360 365His Pro Lys Leu Glu Lys Leu Val Tyr Glu Lys Tyr Gly Lys Asn Ser
370 375 380Thr Ser Arg Ser Val Gly Lys Thr Thr Arg Asp Thr Leu Ile Gln Ser385 390 395 400Ile Arg Met Ala Ser Asp Val Val Lys Asp Arg Gly Val Ile Gly Phe
405 410 415Val Val Asn Gly Gly Phe Ile Asp Ser Lys Ser Ala Asp Gly Phe Arg
420 425 430Lys Cys Val Ala Lys Glu Phe Ser His Leu Tyr Val Leu Asn Leu Arg
435 440 445Gly Asn Gln Arg Thr Ser Gly Glu Val Ser Lys Lys Glu Gly Gly Lys
450 455 460Ile Phe Asp Ser Gly Ser Arg Ala Thr Val Ala Ile Ile Phe Phe Val465 470 475 480Lys Asp Lys Ser Thr Pro Asp Asn Thr Ile Phe Tyr Tyr Glu Val Glu
485 490 495Asp Tyr Leu Lys Arg Glu Ala Lys Leu Asn Trp Leu Ala Asn Phe Glu
500 505 510Asn Leu Asp Phe Val Pro Phe Glu Lys Ile Thr Pro Asn Asp Lys Gly
515 520 525Asp Trp Ile Asn Gln Arg Asn Asp Ala Phe Glu Lys Leu Ile Pro Leu
530 535 540Lys Arg Asp Lys Thr Leu Gln Asn Asp Ser Val Phe Asp Ile Asn Ser545 550 555 560Leu Gly Val Val Ser Gly Arg Asp Pro Trp Val Tyr Asn Phe Ser Pro
565 570 575Asn Ile Leu Thr Gln Ser Val Gln Lys Cys Ile Asp Thr Tyr Asn Ala
580 585 590Asp Leu Lys Arg Phe Asn Ala Arg Phe Arg Glu Ala Phe Lys Gln Arg
595 600 605Ala Gln Ser Val Lys Ala Gly Asp Leu Tyr Lys Gln Leu Asn Asp Lys
610 615 620Glu Ile Thr Thr Asp Lys Thr Lys Ile Ala Trp Thr Asp Gly Leu Lys625 630 635 640Asn Lys Leu Ile Lys Asn Lys Ser Ala Arg Glu Ser Ser Glu Glu Arg
645 650 655Val Arg Leu Ala Leu Tyr Arg Pro Phe Asn Lys Gln Trp Leu Tyr Trp
660 665 670Asp Lys Asp Trp Ile Asn Arg Gln Arg Glu Phe Ser Lys Ile Phe Pro
675 680 685Asp Lys Asp Ala Gln Asn Val Val Ile Asn Thr Gly Val Gly Asn Gly
690 695 700Lys Asp Phe Ser Ala Leu Val Ser Asp Phe Ile Ser Asp Tyr Ser Leu705 710 715 720Ile Ser Pro Asn Gln Ala Tyr Pro Leu Tyr Tyr Tyr Asp Asp Leu Gly
725 730 735Asn Arg His Tyr Ala Ile Ser Gly Tyr Cys Leu Asn Leu Phe Arg Arg
740 745 750His Tyr Gly Asp Asn Leu Ile Ala Glu Glu Glu Ile Phe Tyr Tyr Ile
755 760 765Tyr Ala Ile Phe His His Lys Gly Tyr Leu Glu Lys Tyr Lys Asn Ser
770 775 780Leu Ala Lys Glu Ala Pro Arg Ile Ala Leu Ser Glu Asp Phe Lys Glu785 790 795 800Leu Ser Val Leu Gly Lys Glu Leu Ala Glu Leu His Leu Asn Tyr Glu
805 810 815Ser Gly Glu Met His Asp Asn Ile Lys Tyr Thr Thr Leu Met Asn Ala
820 825 830Glu Ile Glu Gly Tyr Tyr Asp Val Asp Lys Met Thr Lys Lys Gly Asp
835 840 845Cys Ile Ile Tyr Asn Gln Asn Ile Ala Ile Thr Lys Ile Pro Lys Lys
850 855 860Ala Phe Asp Tyr Val Ile Asn Gly Lys Ser Ala Ile Asp Trp Val Ile865 870 875 880Glu Arg Tyr Gln Lys Thr Met Asp Lys Glu Ser Leu Ile Glu Asn Asn
885 890 895Pro Asn Asp Tyr Ala Gly Gly Lys Tyr Val Phe Glu Leu Leu Cys Arg
900 905 910Val Ile Thr Leu Ser Val Lys Ser Val Asp Leu Ile Glu Lys Ile Ser
915 920 925Glu Lys Arg Phe Glu
930
(2) Sequence 799 data:
(i) sequence characteristics:
(A) length: 1440bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 24...1370
(D) Other information:
(xi) Description of the sequence: sequence 799: AAGATCAGCG AAAAGAGGTT TGA GTG ATT ACA TCG CTT GGG GGT GTG GAA TAT 53
Val Ile Thr Ser Leu Gly Gly Val Glu Tyr
1 5 10TTT GAA AGG CAA TGT CTT GCT TTC TTA AAA AAT CCA CAA ACT AAT CCA 101Phe Glu Arg Gln Cys Leu Ala Phe Leu Lys Asn Pro Gln Thr Asn Pro
15 20 25CAA AAT GAG CAA TAC ATT CCA GGA GTG TTT TCG TAT CAA GAA AAC AAA 149Gln Asn Glu Gln Tyr Ile Pro Gly Val Phe Ser Tyr Gln Glu Asn Lys
30 35 40ATT TCT TTT TCT TTT TTG GTT TTA GGA GAA ATT GAA GAG ATC CAC TCT 197Ile Ser Phe Ser Phe Leu Val Leu Gly Glu Ile Glu Glu Ile His Ser
45 50 55TTG CAA TAC CAA ACG CTC TAT ATT GTG GAT AAC AAA AAA AGA TAC ACT 245Leu Gln Tyr Gln Thr Leu Tyr Ile Val Asp Asn Lys Lys Arg Tyr Thr
60 65 70CTT TAG AAG CTT TAT GAT CGC ATT ATT TTG GGT CAT ACT TTA GGG TAT 293Leu Tyr Lys Leu Tyr Asp Arg Ile Ile Leu Gly His Thr Leu Gly Tyr75 80 85 90TCT GCA CCA ATC ACG CTC TAT TAT GAA TGG CTG TTT GAT GAT TGG ATC 341Ser Ala Pro Ile Thr Leu Tyr Tyr Glu Trp Leu Phe Asp Asp Trp Ile
95 100 105GAT CCA GAA AAA ATT ATG GGC GAT CGT TTT GTT TGT AGG ACA AAT TAT 389Asp Pro Glu Lys Ile Met Gly Asp Arg Phe Val Cys Arg Thr Asn Tyr
110 115 120TTA GAA AGT TTT TTT ACG ACC AAG AAG CAT TTG CTA CCT GAT ACA TTA 437Leu Glu Ser Phe Phe Thr Thr Lys Lys His Leu Leu Pro Asp Thr Leu
125 130 135TTT AAA GTA GAT GAA AGT GGG TGT GAA AGT TAT CAT GAG AAT AAC GAT 485Phe Lys Val Asp Glu Ser Gly Cys Glu Ser Tyr His Glu Asn Asn Asp
140 145 150AAG GAC TTT ATC CTA CAA TCA TTT TAT ATT CAA AAT GAT TTT TTA TCC 533Lys Asp Phe Ile Leu Gln Ser Phe Tyr Ile Gln Asn Asp Phe Leu Ser155 160 165 170CAA AGA TAT GAA AAA GAC AAG ATA AAA GCA AAA TCT AAT TTG ATT CCT 581Gln Arg Tyr Glu Lys Asp Lys Ile Lys Ala Lys Ser Asn Leu Ile Pro
175 180 185AAA AGA CAG AAT CGT TTA TTA ACT TAT CAA TTT GAT TTG TCT TTG GAA 629Lys Arg Gln Asn Arg Leu Leu Thr Tyr Gln Phe Asp Leu Ser Leu Glu
190 195 200TGC AAT ATA ATT TTT GAA ACC CTT GAA AAA TTA GCA CTT ATT GCT GGA 677Cys Asn Ile Ile Phe Glu Thr Leu Glu Lys Leu Ala Leu Ile Ala Gly
205 210 215GCG ATT AAA AAC TTT TTT ATT TTG ATT TAT GCT CAT TCT AAT TTT GAC 725Ala Ile Lys Asn Phe Phe Ile Leu Ile Tyr Ala His Ser Asn Phe Asp
220 225 230ATC CAA ATT GAC TAT ATC CAA TTC AAG CTT TCT AAT AAA GAC ATT ACA 773Ile Gln Ile Asp Tyr Ile Gln Phe Lys LeuSer Asn Lys Asp Ile Thr235 240 245 250GCA ATA AGA AAC ACT TAC AAA AAA GAT AAA AAG TCT ATG GAG ATA GAT 821Ala Ile Arg Asn Thr Tyr Lys Lys Asp Lys Lys Ser Met Glu Ile Asp
255 260 265CTT TAT GGG ATT GCT ATA AAT TTC CAA CGG ATA GAC AAT TTT TCT GTA 869Leu Tyr Gly Ile Ala Ile Asn Phe Gln Arg Ile Asp Asn Phe Ser Val
270 275 280ATA CTT GAA AAA TGG ATT GTT TTT TAT ATC AAA GAC AAT AGA GAT TTC 917Ile Leu Glu Lys Trp Ile Val Phe Tyr Ile Lys Asp Asn Arg Asp Phe
285 290 295CAA CTT GCA AGT ATT TTA GAC ATT ATT AAT AAA AAA GAT CCA ATT ATT 965Gln Leu Ala Ser Ile Leu Asp Ile Ile Asn Lys Lys Asp Pro Ile Ile
300 305 310CAC TTG TAT TTG GAC ATG TTT GTA TTG ATT AGC ATG ATT GAA AGT TTT 1013His Leu Tyr Leu Asp Met Phe Val Leu Ile Ser Met Ile Glu Ser Phe315 320 325 330TTA AAG AAA CCA CAA CAA ACA AAA CTC CAT GAA AAA CTC TCT GAA TTT 1061Leu Lys Lys Pro Gln Gln Thr Lys Leu His Glu Lys Leu Ser Glu Phe
335 340 345TTT AAA ATT TCA TTA TCT AGG ACA AAA TGC GAT CAA ACG AAA AAT TAT 1109Phe Lys Ile Ser Leu Ser Arg Thr Lys Cys Asp Gln Thr Lys Asn Tyr
350 355 360TTT AAT GAT AAA TGT CAA GAA GAT CTA ATC CAA CAG ATT GTT GAC TGC 1157Phe Asn Asp Lys Cys Gln Glu Asp Leu Ile Gln Gln Ile Val Asp Cys
365 370 375CGT AAC TCT CTA GCG CAC GGA AGA AGT TTA AAG CTT GAT ACA AAC AAA 1205Arg Asn Ser Leu Ala His Gly Arg Ser Leu Lys Leu Asp Thr Asn Lys
380385 390GCT ACA GAC ATT AGC CAT GCT TTT ATA GAT TTC AAG CAA ATT GTC ATT 1253Ala Thr Asp Ile Ser His Ala Phe Ile Asp Phe Lys Gln Ile Val Ile395 400 405 410GAA TTT TTC TTT GGC GAG ATA GGA TTG AGC GAT TTT ATT ACA AAC AAT 1301Glu Phe Phe Phe Gly Glu Ile Gly Leu Ser Asp Phe Ile Thr Asn Asn
415 420 425TTT GGT TTT CTT AAC AAA GTT AAA TTA AGA AAC CCC CCA AAA ACA GAA 1349Phe Gly Phe Leu Asn Lys Val Lys Leu Arg Asn Pro Pro Lys Thr Glu
430 435 440AAA ATC ACC GAG CCA AAC CGC TAAAACCCCT TAGAAAATTT AAAATTTTAA GTTT 1404Lys Ile Thr Glu Pro Asn Arg
445TAGGGGTGTT TTTCTTAAGA ATTTAGGTTT TTTATA 1440
(2) Sequence 800 data:
(i) sequence characteristics:
(A) length: 449 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 800: val Ile Thr Ser Leu Gly Gly Val Glu Tyr Phe Glu Arg Gln Cys Leu 151015 Ala Phe Leu Lys Asn Pro Gln Thr Asn Pro Gln Asn Glu Gln Tyr Ile
20 25 30Pro Gly Val Phe Ser Tyr Gln Glu Asn Lys Ile Ser Phe Ser Phe Leu
35 40 45Val Leu Gly Glu Ile Glu Glu Ile His Ser Leu Gln Tyr Gln Thr Leu
50 55 60Tyr Ile Val Asp Asn Lys Lys Arg Tyr Thr Leu Tyr Lys Leu Tyr Asp6570 75 80Arg Ile Ile Leu Gly His Thr Leu Gly Tyr Ser Ala Pro Ile Thr Leu
85 90 95Tyr Tyr Glu Trp Leu Phe Asp Asp Trp Ile Asp Pro Glu Lys Ile Met
100 105 110Gly Asp Arg Phe Val Cys Arg Thr Asn Tyr Leu Glu Ser Phe Phe Thr
115 120 125Thr Lys Lys His Leu Leu Pro Asp Thr Leu Phe Lys Val Asp Glu Ser
130 135 140Gly Cys Glu Ser Tyr His Glu Asn Asn Asp Lys Asp Phe Ile Leu Gln145 150 155 160Ser Phe Tyr Ile Gln Asn Asp Phe Leu Ser Gln Arg Tyr Glu Lys Asp
165 170 175Lys Ile Lys Ala Lys Ser Asn Leu Ile Pro Lys Arg Gln Asn Arg Leu
180 185 190Leu Thr Tyr Gln Phe Asp Leu Ser Leu Glu Cys Asn Ile Ile Phe Glu
195 200 205Thr Leu Glu Lys Leu Ala Leu Ile Ala Gly Ala Ile Lys Asn Phe Phe
210 215 220Ile Leu Ile Tyr Ala His Ser Asn Phe Asp Ile Gln Ile Asp Tyr Ile225 230 235 240Gln Phe Lys Leu Ser Asn Lys Asp Ile Thr Ala Ile Arg Asn Thr Tyr
245 250 255Lys Lys Asp Lys Lys Ser Met Glu Ile Asp Leu Tyr Gly Ile Ala Ile
260 265 270Asn Phe Gln Arg Ile Asp Asn Phe Ser Val Ile Leu Glu Lys Trp Ile
275 280 285Val Phe Tyr Ile Lys Asp Asn Arg Asp Phe Gln Leu Ala Ser Ile Leu
290 295 300Asp Ile Ile Asn Lys Lys Asp Pro Ile Ile His Leu Tyr Leu Asp Met305 310 315 320Phe Val Leu Ile Ser Met Ile Glu Ser Phe Leu Lys Lys Pro Gln Gln
325 330 335Thr Lys Leu His Glu Lys Leu Ser Glu Phe Phe Lys Ile Ser Leu Ser
340 345 350Arg Thr Lys Cys Asp Gln Thr Lys Asn Tyr Phe Asn Asp Lys Cys Gln
355 360 365Glu Asp Leu Ile Gln Gln Ile Val Asp Cys Arg Asn Ser Leu Ala His
370 375 380Gly Arg Ser Leu Lys Leu Asp Thr Asn Lys Ala Thr Asp Ile Ser His385 390 395 400Ala Phe Ile Asp Phe Lys Gln Ile Val Ile Glu Phe Phe Phe Gly Glu
405 410 415Ile Gly Leu Ser Asp Phe Ile Thr Asn Asn Phe Gly Phe Leu Asn Lys
420 425 430Val Lys Leu Arg Asn Pro Pro Lys Thr Glu Lys Ile Thr Glu Pro Asn
435 440 445Arg
(2) Sequence 801 data:
(i) sequence characteristics:
(A) length: 1345bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...1302
(D) Other information:
(xi) Description of the sequence: sequence 801: CTAAATGAAT TTAAAAGGAA AAAT ATG GCA GTA AGA TTT GGG ATT ATC TTT 51
Met Ala Val Arg Phe Gly Ile Ile Phe
1 5ATA TCT GAC TCT ATT GAT GAT TAT AAA GCC AAA CAA TTA AGA TCA ATT 99Ile Ser Asp Ser Ile Asp Asp Tyr Lys Ala Lys Gln Leu Arg Ser Ile10 15 20 25TTA GAA CGC AAG AAA GAG TGT AAT TTT ATA TGG TTT AAT GAA TCA AGT 147Leu Glu Arg Lys Lys Glu Cys Asn Phe Ile Trp Phe Asn Glu Ser Ser
30 35 40GCT ATA ATT CAC AAT ACT CCT AAA GTT TTT GAA GGA GAG AGT TTT TTT 195Ala Ile Ile His Asn Thr Pro Lys Val Phe Glu Gly Glu Ser Phe Phe
45 50 55GAT CAT CTT TTC GTT AGT GCA AAA ATT ACT GCT TTT GTG GTA TCC ACA 243Asp His Leu Phe Val Ser Ala Lys Ile Thr Ala Phe Val Val Ser Thr
60 65 70AAC GAA TCA GAT ACA ATA TTC AAT TTA AAA AAC TAC TTG CTA GTA TTA 291Asn Glu Ser Asp Thr Ile Phe Asn Leu Lys Asn Tyr Leu Leu Val Leu
75 80 85GCC AAA AAT CTC AAT AAT AGA GAT ATT TGG TAT TGT GAA AAC ACT ATT 339Ala Lys Asn Leu Asn Asn Arg Asp Ile Trp Tyr Cys Glu Asn Thr Ile90 95 100 105TGC GAT AAA AAA GGC ACT TAT AAT ATA GAA ATA GAA TTA GTG AGC AAT 387Cys Asp Lys Lys Gly Thr Tyr Asn Ile Glu Ile Glu Leu Val Ser Asn
110 115 120GCT AAT GAT TTT AGA GGA GTG TTT GGA GAA GTG TTA GGT ATA GTC AAA 435Ala Asn Asp Phe Arg Gly Val Phe Gly Glu Val Leu Gly Ile Val Lys
125 130 135GAC ACT TTC GGT GAT TTA CTG CAA CTT CTT ACA AAT TTA AAG AAC AAG 483Asp Thr Phe Gly Asp Leu Leu Gln Leu Leu Thr Asn Leu Lys Asn Lys
140 145 150GAA ATT GAA TTT AAT TTT CAT AAA AAA ATT AAT TAC GGA TTG CCT TTT 531Glu Ile Glu Phe Asn Phe His Lys Lys Ile Asn Tyr Gly Leu Pro Phe
155 160 165GGG ATT ATC TTT ATC GCT AGC AAC TCT GAC AAC CCT ATT GAT ATT GAC 579Gly Ile Ile Phe Ile Ala Ser Asn Ser Asp Asn Pro Ile Asp Ile Asp170 175 180 185AAT AAA ACC AAA AAG TTA AAA TCA TGC TTT CGT GAT GAT GAG AGT AAC 627Asn Lys Thr Lys Lys Leu Lys Ser Cys Phe Arg Asp Asp Glu Ser Asn
190 195 200TGT TTT ATT GAC TGC CCA ATT ACA ATT GAG GAT TAT TTA ATT TTA GAT 675Cys Phe Ile Asp Cys Pro Ile Thr Ile Glu Asp Tyr Leu Ile Leu Asp
205 210 215AAT CTA AAA AGC TGT TTT GTA ATC CAA AAT AAG CCA AAT GTA ACA TTA 723Asn Leu Lys Ser Cys Phe Val Ile Gln Asn Lys Pro Asn Val Thr Leu
220 225 230TTT GAT AAC GAC GAG AAC GAT AGA CCA TTC AAT TTA AAG CGA TAC TTG 771Phe Asp Asn Asp Glu Asn Asp Arg Pro Phe Asn Leu Lys Arg Tyr Leu
235 240 245TTA GGA TTG AAA GAA AAG TTA GGG TTT GAG CCA ACG GGT ATT TTC TAT 819Leu Gly Leu Lys Glu Lys Leu Gly Phe Glu Pro Thr Gly Ile Phe Tyr250 255 260 265TGC GAA AAC GCA AAC ACA CAC AAA ATT GAA TTG ATT GGT AAT GAT TCT 867Cys Glu Asn Ala Asn Thr His Lys Ile Glu Leu Ile Gly Asn Asp Ser
270 275 280GAT TTC AGA GAG GTA TTA CTT GAA TTT TCA GAG AAT ATA CCA AAA GCC 915Asp Phe Arg Glu Val Leu Leu Glu Phe Ser Glu Asn Ile Pro Lys Ala
285 290 295CCT AAT GAA CTA CCA CAA TTT CTT ACA AAC TTT AAA AAT TCA AAA ATC 963Pro Asn Glu Leu Pro Gln Phe Leu Thr Asn Phe Lys Asn Ser Lys Ile
300 305 310CCC AAT GGA AAC ATT TCA TTT TCG CCA CCA AAA AAT TCT CCA TCA ATT 1011Pro Asn Gly Asn Ile Ser Phe Ser Pro Pro Lys Asn Ser Pro Ser Ile
315 320 325TCT TCA TAT GCT TTA TCT GAT AAG ATT AAA AGA GAA GTA AGA GAT ACC 1059Ser Ser Tyr Ala Leu Ser Asp Lys Ile Lys Arg Glu Val Arg Asp Thr330 335 340 345TTT GAT CGC TAT TTG TGG CAT GGT TAT TCT AAA ATT CCA CAG GAG AAA 1107Phe Asp Arg Tyr Leu Trp His Gly Tyr Ser Lys Ile Pro Gln Glu Lys
350 355 360AGG ATA GCC AAA ATA AAA GAG CAA GTG AAG GAA GAA ATT AAA CTA AAT 1155Arg Ile Ala Lys Ile Lys Glu Gln Val Lys Glu Glu Ile Lys Leu Asn
365 370 375CCT TCT TTT CGT AAT TAT AGA GTA GAC TCT GAA CAA AAC CGC AAG ATC 1203Pro Ser Phe Arg Asn Tyr Arg Val Asp Ser Glu Gln Asn Arg Lys Ile
380 385 390AAT GAA ATT GCT GAG GGT TTA AAA AGT GGT AAG ATA ATT GGT AAA AAG 1251Asn Glu Ile Ala Glu Gly Leu Lys Ser Gly Lys Ile Ile Gly Lys Lys
395 400 405GTT ATT GCT AAT GCG TTC GAT CTA AAT GCT AGC TTA TTG TTT TAT TAC 1299Val Ile Ala Asn Ala Phe Asp Leu Asn Ala Ser Leu Leu Phe Tyr Tyr410 415 420 425TCC TGATGATTTA AAGAATTTAA AGGAACGATT ATTTATAGAT ATT 1345Ser
(2) Sequence 802 data:
(i) sequence characteristics:
(A) length: 426 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 802: met Ala Val Arg Phe Gly Ile Ile Phe Ile Ser Asp Ser Ile Asp Asp 151015 Tyr Lys Ala Lys Gln Leu Arg Ser Ile Leu Glu Arg Lys Lys Glu Cys
20 25 30Asn Phe Ile Trp Phe Asn Glu Ser Ser Ala Ile Ile His Asn Thr Pro
35 40 45Lys Val Phe Glu Gly Glu Ser Phe Phe Asp His Leu Phe Val Ser Ala
50 55 60Lys Ile Thr Ala Phe Val Val Ser Thr Asn Glu Ser Asp Thr Ile Phe65 70 75 80Asn Leu Lys Asn Tyr Leu Leu Val Leu Ala Lys Asn Leu Asn Asn Arg
85 90 95Asp Ile Trp Tyr Cys Glu Asn Thr Ile Cys Asp Lys Lys Gly Thr Tyr
100 105 110Asn Ile Glu Ile Glu Leu Val Ser Asn Ala Asn Asp Phe Arg Gly Val
115 120 125Phe Gly Glu Val Leu Gly Ile Val Lys Asp Thr Phe Gly Asp Leu Leu
130 135 140Gln Leu Leu Thr Asn Leu Lys Asn Lys Glu Ile Glu Phe Asn Phe His145 150 155 160Lys Lys Ile Asn Tyr Gly Leu Pro Phe Gly Ile Ile Phe Ile Ala Ser
165170 175Asn Ser Asp Asn Pro Ile Asp Ile Asp Asn Lys Thr Lys Lys Leu Lys
180 185 190Ser Cys Phe Arg Asp Asp Glu Ser Asn Cys Phe Ile Asp Cys Pro Ile
195 200 205Thr Ile Glu Asp Tyr Leu Ile Leu Asp Asn Leu Lys Ser Cys Phe Val
210 215 220Ile Gln Asn Lys Pro Asn Val Thr Leu Phe Asp Asn Asp Glu Asn Asp225 230 235 240Arg Pro Phe Asn Leu Lys Arg Tyr Leu Leu Gly Leu Lys Glu Lys Leu
245 250 255Gly Phe Glu Pro Thr Gly Ile Phe Tyr Cys Glu Asn Ala Asn Thr His
260 265 270Lys Ile Glu Leu Ile Gly Asn Asp Ser Asp Phe Arg Glu Val Leu Leu
275 280 285Glu Phe Ser Glu Asn Ile Pro Lys Ala Pro Asn Glu Leu Pro Gln Phe
290 295 300Leu Thr Asn Phe Lys Asn Ser Lys Ile Pro Asn Gly Asn Ile Ser Phe305 310 315 320Ser Pro Pro Lys Asn Ser Pro Ser Ile Ser Ser Tyr Ala Leu Ser Asp
325 330 335Lys Ile Lys Arg Glu Val Arg Asp Thr Phe Asp Arg Tyr Leu Trp His
340 345 350Gly Tyr Ser Lys Ile Pro Gln Glu Lys Arg Ile Ala Lys Ile Lys Glu
355 360 365Gln Val Lys Glu Glu Ile Lys Leu Asn Pro Ser Phe Arg Asn Tyr Arg
370 375 380Val Asp Ser Glu Gln Asn Arg Lys Ile Asn Glu Ile Ala Glu Gly Leu385 390 395 400Lys Ser Gly Lys Ile Ile Gly Lys Lys Val Ile Ala Asn Ala Phe Asp
405 410 415Leu Asn Ala Ser Leu Leu Phe Tyr Tyr Ser
420 425
(2) Sequence 803 data:
(i) sequence characteristics:
(A) length: 720bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 22...705
(D) Other information:
(xi) Description of the sequence: sequence 803: TTGCTAATGC GTTCGATCTA A ATG CTA GCT TAT TGT TTT ATT ACT CCT GAT 51
Met Leu Ala Tyr Cys Phe Ile Thr Pro Asp
1 5 10GAT TTA AAG AAT TTA AAG GAA CGA TTA TTT ATA GAT ATT ATC AAT GCT 99Asp Leu Lys Asn Leu Lys Glu Arg Leu Phe Ile Asp Ile Ile Asn Ala
15 20 25ATC AAC CAA AAA AAG AGA GTC GCG CTC GAT CAT GCT CAA ATA GAT GAC 147Ile Asn Gln Lys Lys Arg Val Ala Leu Asp His Ala Gln Ile Asp Asp
30 35 40ATC CAG TAT AAT GTG CTT GAT AAT GCG TTT TAT TTT ATC TTT GAT GTT 195Ile Gln Tyr Asn Val Leu Asp Asn Ala Phe Tyr Phe Ile Phe Asp Val
45 50 55GGT AAC CCT TCT CAA TTA GCT ATT AAA GTG CCT AGA AAA TCT TTA GAA 243Gly Asn Pro Ser Gln Leu Ala Ile Lys Val Pro Arg Lys Ser Leu Glu
60 65 70AAT GAT GAG TTG CCC AAC ACT AAA AAA AAC ATA TTC AAT GGA TTA ATA 291Asn Asp Glu Leu Pro Asn Thr Lys Lys Asn Ile Phe Asn Gly Leu Ile75 80 85 90AGA ACT ATC TAT GGG TGT ATT GAT GAT GAA AAT TCA TTT TTA TTA GAA 339Arg Thr Ile Tyr Gly Cys Ile Asp Asp Glu Asn Ser Phe Leu Leu Glu
95 100 105AAC GAT AAA ACC ATC AAG GAT TTA AAT ATT CAG GAT TTA TTG GGG CCA 387Asn Asp Lys Thr Ile Lys Asp Leu Asn Ile Gln Asp Leu Leu Gly Pro
110 115 120TTA AAA ACT CAA GCA TTT CCA TTA TCA TAC ATT ATT ACT GAC GCT ATC 435Leu Lys Thr Gln Ala Phe Pro Leu Ser Tyr Ile Ile Thr Asp Ala Ile
125 130 135AAT CAA AAA GAA GGG GTG GCT CTC GAT TAC GCT CTA ATA AAC GAT ATT 483Asn Gln Lys Glu Gly Val Ala Leu Asp Tyr Ala Leu Ile Asn Asp Ile
140 145 150AAG TAT AAT TTG CTT GAT AAC ACA TTC CAT TTT ATC TTT GAT GTT GGT 531Lys Tyr Asn Leu Leu Asp Asn Thr Phe His Phe Ile Phe Asp Val Gly155 160 165 170AAT CCT TTG TTG AAA GAG TCA AGT CAA TTT ATT ATT GAA GTG CCT AGA 579Asn Pro Leu Leu Lys Glu Ser Ser Gln Phe Ile Ile Glu Val Pro Arg
175 180 185GAG GCG TTG GAT CTA GAG AAT GTT GAT CGG CTT GTT GAA TAT ACG CTG 627Glu Ala Leu Asp Leu Glu Asn Val Asp Arg Leu Val Glu Tyr Thr Leu
190 195 200TCT CCT AAT AAT CAT AGT CAA AGT TCT TTA GTG TAT CAT ATT TCT GAA 675Ser Pro Asn Asn His Ser Gln Ser Ser LeuVal Tyr His Ile Ser Glu
205 210 215GGC TCT TAT ATC ATT CAC TTA ATA GAT GAC TAAACTTAAA TGAAA 720Gly Ser Tyr Ile Ile His Leu Ile Asp Asp
220 225
(2) Sequence 804 data:
(i) sequence characteristics:
(A) length: 228 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 804: met Leu Ala Tyr Cys Phe Ile Thr Pro Asp Asp Leu Lys Asn Leu Lys 151015 Glu Arg Leu Phe Ile Asp Ile Ile Asn Ala Ile Asn Gln Lys Lys Arg
20 25 30Val Ala Leu Asp His Ala Gln Ile Asp Asp Ile Gln Tyr Asn Val Leu
35 40 45Asp Asn Ala Phe Tyr Phe Ile Phe Asp Val Gly Asn Pro Ser Gln Leu
50 55 60Ala Ile Lys Val Pro Arg Lys Ser Leu Glu Asn Asp Glu Leu Pro Asn65 70 75 80Thr Lys Lys Asn Ile Phe Asn Gly Leu Ile Arg Thr Ile Tyr Gly Cys
85 90 95Ile Asp Asp Glu Asn Ser Phe Leu Leu Glu Asn Asp Lys Thr Ile Lys
100 105 110Asp Leu Asn Ile Gln Asp Leu Leu Gly Pro Leu Lys Thr Gln Ala Phe
115 120 125Pro Leu Ser Tyr Ile Ile Thr Asp Ala Ile Asn Gln Lys Glu Gly Val
130135 140Ala Leu Asp Tyr Ala Leu Ile Asn Asp Ile Lys Tyr Asn Leu Leu Asp145 150 155 160Asn Thr Phe His Phe Ile Phe Asp Val Gly Asn Pro Leu Leu Lys Glu
165 170 175Ser Ser Gln Phe Ile Ile Glu Val Pro Arg Glu Ala Leu Asp Leu Glu
180 185 190Asn Val Asp Arg Leu Val Glu Tyr Thr Leu Ser Pro Asn Asn His Ser
195 200 205Gln Ser Ser Leu Val Tyr His Ile Ser Glu Gly Ser Tyr Ile Ile His
210 215 220Leu Ile Asp Asp225
(2) Sequence 805 data:
(i) sequence characteristics:
(A) length: 611bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...561
(D) Other information:
(xi) Description of the sequence: sequence 805: TTTGGGCATG CTTGGTGATC TTAA ATG AGT CAA GGT GAT GGG GTG GAA GGA 51
Met Ser Gln Gly Asp Gly Val Glu Gly
1 5AAT AAT ATG GAT ACT ACG AAA GAG AAC TTG AAT GGC TCA AAA GAG CGT 99Asn Asn Met Asp Thr Thr Lys Glu Asn Leu Asn Gly Ser Lys Glu Arg10 15 20 25TTG AGC GATTGG GAA TAT CGA TGG GCA ATG GCT CTA GTC TAT GGA GGA 147Leu Ser Asp Trp Glu Tyr Arg Trp Ala Met Ala Leu Val Tyr Gly Gly
30 35 40TGT ATC TCC ATA ACC ACT AGG ATT TTT TAT GAC ATA AAT GGT TCA GCT 195Cys Ile Ser Ile Thr Thr Arg Ile Phe Tyr Asp Ile Asn Gly Ser Ala
45 50 55AGC GAT CCG CTT TTT GAC CCT AAA TAC AGC TAT TAT GTG TGG TTA GTG 243Ser Asp Pro Leu Phe Asp Pro Lys Tyr Ser Tyr Tyr Val Trp Leu Val
60 65 70GCT CTA ATA GCG GCT TTG TTG TCT AAT CTC TTG TTT AAT CCT AAA GGC 291Ala Leu Ile Ala Ala Leu Leu Ser Asn Leu Leu Phe Asn Pro Lys Gly
75 80 85AGG TCG GTA GGT TAT TTA ATG ATT GAA ACT TGG CAA GGG TTC CCC AAG 339Arg Ser Val Gly Tyr Leu Met Ile Glu Thr Trp Gln Gly Phe Pro Lys90 95 100 105TTT TTT AAA GCC ATT TTT AAG GCT AGG TTT TTT GGT GCG TTT TAT GAC 387Phe Phe Lys Ala Ile Phe Lys Ala Arg Phe Phe Gly Ala Phe Tyr Asp
110 115 120GCT GTG TTA GGA TCA AGG CTA AGG GAT TTT TAT GTG ATG CTT TTA ACG 435Ala Val Leu Gly Ser Arg Leu Arg Asp Phe Tyr Val Met Leu Leu Thr
125 130 135ATG CCC TTT ATT GCC GCT ATC CAT GAG GTT TCG GCG TAT TGT GGG CAT 483Met Pro Phe Ile Ala Ala Ile His Glu Val Ser Ala Tyr Cys Gly His
140 145 150CCT AGC AAT CTC CTT GTA GAG GGT TTG GTC ATT TTG GGG TTT CAA GGT 531Pro Ser Asn Leu Leu Val Glu Gly Leu Val Ile Leu Gly Phe Gln Gly
155 160 165TTT CTT AAG CTT TGC GCT AAA TGG GGG TGG TGATTTAACC CAAATGTCAT TAA 584Phe Leu Lys Leu Cys Ala Lys Trp Gly Trp170 175ATGGAGGGGG TATAAAAAAA TTAAAAA 611
(2) Sequence 806 data:
(i) sequence characteristics:
(A) length: 179 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 806: met Ser Gln Gly Asp Gly Val Glu Gly Asn Asn Met Asp Thr Thr Lys 151015 Glu Asn Leu Asn Gly Ser Lys Glu Arg Leu Ser Asp Trp Glu Tyr Arg
20 25 30Trp Ala Met Ala Leu Val Tyr Gly Gly Cys Ile Ser Ile Thr Thr Arg
35 40 45Ile Phe Tyr Asp Ile Asn Gly Ser Ala Ser Asp Pro Leu Phe Asp Pro
50 55 60Lys Tyr Ser Tyr Tyr Val Trp Leu Val Ala Leu Ile Ala Ala Leu Leu65 70 75 80Ser Asn Leu Leu Phe Asn Pro Lys Gly Arg Ser Val Gly Tyr Leu Met
85 90 95Ile Glu Thr Trp Gln Gly Phe Pro Lys Phe Phe Lys Ala Ile Phe Lys
100 105 110Ala Arg Phe Phe Gly Ala Phe Tyr Asp Ala Val Leu Gly Ser Arg Leu
115 120 125Arg Asp Phe Tyr Val Met Leu Leu Thr Met Pro Phe Ile Ala Ala Ile
130 135 140His Glu Val Ser Ala Tyr Cys Gly His Pro Ser Asn Leu Leu Val Glu145 150 155 160Gly Leu Val Ile Leu Gly Phe Gln Gly Phe Leu Lys Leu Cys Ala Lys
165 170 175Trp Gly Trp
(2) Data in sequence 807:
(i) sequence characteristics:
(A) length: 424bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 72...404
(D) Other information:
(xi) Description of the sequence: sequence 807: GTTGTGGTAT AAATATTCTT ATCAAGGTGT GCCAAACATG CCTTGAATCT CAATTTTTGA 60ATCTCAATTT T ATG AAA GGA TTT GTT ATG AGT GGA TTA AGA ACA TTT AGT 110
Met Lys Gly Phe Val Met Ser Gly Leu Arg Thr Phe Ser
1 5 10TGT GTA GTG GTT TTA TGC GGT GCA ATG GCT AAT GTG GCT ATA GCT AGT 158Cys Val Val Val Leu Cys Gly Ala Met Ala Asn Val Ala Ile Ala Ser
15 20 25CCT AAA ATA GAG GCA AGG GGT GAA TTA GGC AAA TTT ATA GGG GGT GGT 206Pro Lys Ile Glu Ala Arg Gly Glu Leu Gly Lys Phe Ile Gly Gly Gly30 35 40 45GTT GGG GGT TTT GTT GGT GAT AAA ATG GGC GGA TTT GTT GGT GGT GCA 254Val Gly Gly Phe Val Gly Asp Lys Met Gly Gly Phe Val Gly Gly Ala
50 55 60ATA GGA GGA TAT ATT GGG TCT GAA ATA GGC GAT AGG GTA GAA GAT TAT 302Ile Gly Gly Tyr Ile Gly Ser Glu IleGly Asp Arg Val Glu Asp Tyr
65 70 75ATC CGT GGT GTT GAT AGA GAG CCA CAA AAC AAA GAA CCA CAA GCC CCA 350Ile Arg Gly Val Asp Arg Glu Pro Gln Asn Lys Glu Pro Gln Ala Pro
80 85 90AGA GAA CCT ATC CGT GAT CTT TAT GAT TAC GGC TAT AGT TTT GGG CAT 398Arg Glu Pro Ile Arg Asp Leu Tyr Asp Tyr Gly Tyr Ser Phe Gly His
95 100 105GCT TGG TGATCTTAAA TGAGTCAAGA 424Ala Trp110
(2) Sequence 808 data:
(i) sequence characteristics:
(A) length: 111 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 808: met Lys Gly Phe Val Met Ser Gly Leu Arg Thr Phe Ser Cys Val Val 151015 Val Leu Cys Gly Ala Met Ala Asn Val Ala Ile Ala Ser Pro Lys Ile
20 25 30Glu Ala Arg Gly Glu Leu Gly Lys Phe Ile Gly Gly Gly Val Gly Gly
35 40 45Phe Val Gly Asp Lys Met Gly Gly Phe Val Gly Gly Ala Ile Gly Gly
50 55 60Tyr Ile Gly Ser Glu Ile Gly Asp Arg Val Glu Asp Tyr Ile Arg Gly65 70 75 80Val Asp Arg Glu Pro Gln Asn Lys Glu Pro Gln Ala Pro Arg Glu Pro
85 90 95Ile Arg Asp Leu Tyr Asp Tyr Gly Tyr Ser Phe Gly His Ala Trp
100 105 110
(2) Sequence 809 data:
(i) sequence characteristics:
(A) length: 630bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 132...569
(D) Other information:
(xi) Description of the sequence: sequence 809: GATTTTAGTG ATGACGAGTT TCACCCGTTT GATCGTGGTG TTTTCTTTTT TAAGGACCGC 60TTTGGGCACG CAACAAACCC CCCCCCACTC AAATTTTAGT CTCGCTCTCT TTGATATTGA 120CTTTTTTCAT C ATG GAA CCT AGC CTA AAA AAG GCC TAT GAT ACA GGG ATT 170
Met Glu Pro Ser Leu Lys Lys Ala Tyr Asp Thr Gly Ile
1 5 10AAG CCT TAT ATG GAT AAA AAG ATT TCT TAC ACC GAA GCG TTT GAA AAA 218Lys Pro Tyr Met Asp Lys Lys Ile Ser Tyr Thr Glu Ala Phe Glu Lys
15 20 25AGC GCT CTG CCC TTC AAG GAA TTC ATG CTT AAA AAC ACA CGA GAA AAG 266Ser Ala Leu Pro Phe Lys Glu Phe Met Leu Lys Asn Thr Arg Glu Lys30 35 40 45GAT CTA GCC CTT TTT TTT AGG ATT AGA AAC CTC CCT AAC CCT AAA ACC 314Asp Leu Ala Leu Phe Phe Arg Ile Arg Asn Leu Pro Asn Pro Lys Thr
50 55 60CCT GAT GAG GTG AGT TTG AGC GTT TTG ATC CCG GCA TTT ATG ATA AGC 362Pro Asp Glu Val Ser Leu Ser ValLeu Ile Pro Ala Phe Met Ile Ser
65 70 75GAG TTG AAA ACA GCG TTT CAA ATC GGC TTT TTA CTC TAC TTG CCT TTT 410Glu Leu Lys Thr Ala Phe Gln Ile Gly Phe Leu Leu Tyr Leu Pro Phe
80 85 90TTG GTG ATT GAT ATG GTG ATC AGC TCT ATT TTA ATG GCG ATG GGC ATG 458Leu Val Ile Asp Met Val Ile Ser Ser Ile Leu Met Ala Met Gly Met
95 100 105ATG ATG CTC CCG CCT GTA ATG ATT TCT CTG CCT TTT AAA ATT TTA GTG 506Met Met Leu Pro Pro Val Met Ile Ser Leu Pro Phe Lys Ile Leu Val110 115 120 125TTT ATT CTG GTA GAT GGG TTT AAT TTA TTG ACC GAA AAT TTA GTG GCG 554Phe Ile Leu Val Asp Gly Phe Asn Leu Leu Thr Glu Asn Leu Val Ala
130 135 140AGT TTT AAA ATG GTT TGATATTAAC AAGCATTCAA GCGATAAAAG CTTGAAGCTA G 610Ser Phe Lys Met Val
145TTTAAAACTC ATAATTCAAA 630
(2) Data of sequence 810:
(i) sequence characteristics:
(A) length: 146 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 810: met Glu Pro Ser Leu Lys Lys Ala Tyr Asp Thr Gly Ile Lys Pro Tyr 151015 Met Asp Lys Lys Ile Ser Tyr Thr Glu Ala Phe Glu Lys Ser Ala Leu
20 25 30Pro Phe Lys Glu Phe Met Leu Lys Asn Thr Arg Glu Lys Asp Leu Ala
35 40 45Leu Phe Phe Arg Ile Arg Asn Leu Pro Asn Pro Lys Thr Pro Asp Glu
50 55 60Val Ser Leu Ser Val Leu Ile Pro Ala Phe Met Ile Ser Glu Leu Lys65 70 75 80Thr Ala Phe Gln Ile Gly Phe Leu Leu Tyr Leu Pro Phe Leu Val Ile
85 90 95Asp Met Val Ile Ser Ser Ile Leu Met Ala Met Gly Met Met Met Leu
100 105 110Pro Pro Val Met Ile Ser Leu Pro Phe Lys Ile Leu Val Phe Ile Leu
115 120 125Val Asp Gly Phe Asn Leu Leu Thr Glu Asn Leu Val Ala Ser Phe Lys
130 135 140Met Val145
(2) Sequence 811 data:
(i) sequence characteristics:
(A) length: 2352bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 13...2313
(D) Other information:
(xi) Description of the sequence: sequence 811: AAAAGGTGGT AA ATG AAA AGA ATT TTA GTC TCT TTG GCT GTT TTG AGT CAT 51
Met Lys Arg Ile Leu Val Ser Leu Ala Val Leu Ser His
1 5 10AGC GCG CAT GCT GTC AAA ACT CAT AAT TTG GAA AGG GTG GAA GCT TCA 99Ser Ala His Ala Val Lys Thr His Asn Leu Glu Arg Val Glu Ala Ser
15 20 25GGG GTG GCT AAC GAT AAG GAA GCG CCT TTA AGC TGG AGG AGC AAG GAA 147Gly Val Ala Asn Asp Lys Glu Ala Pro Leu Ser Trp Arg Ser Lys Glu30 35 40 45GTG AGA AAC TAT ATG GGA TCT CGC ACG GTG ATT TCT AAC AAG CAA CTC 195Val Arg Asn Tyr Met Gly Ser Arg Thr Val Ile Ser Asn Lys Gln Leu
50 55 60ACT AAA AGC GCC AAT CAG AGC ATT GAA GAA GCT TTG CAA AAT GTG CCA 243Thr Lys Ser Ala Asn Gln Ser Ile Glu Glu Ala Leu Gln Asn Val Pro
65 70 75GGC GTG CAT ATT AGA AAC GCT ACG GGT ATT GGA GCT GTG CCT AGC TTT 291Gly Val His Ile Arg Asn Ala Thr Gly Ile Gly Ala Val Pro Ser Phe
80 85 90TCT GTT AGG GGC TTT GGT GGG GGA AGT TCA GGG CAT TCC AAT ACG GCT 339Ser Val Arg Gly Phe Gly Gly Gly Ser Ser Gly His Ser Asn Thr Ala
95 100 105ATG GTT TTA GTC AAT GGG ATC CCT ATT TAT GTT GCG CCC TAT GTT GAT 387Met Val Leu Val Asn Gly Ile Pro Ile Tyr Val Ala Pro Tyr Val Asp110 115 120 125ATT AGC ATT CCT ATT TTC CCT GTA ACC TTT CAA TCT GTA GAT AGA ATC 435Ile Ser Ile Pro Ile Phe Pro Val Thr Phe Gln Ser Val Asp Arg Ile
130 135 140AGC GTA ACC AAG GGT GGG GAG AGC GTG CGT TAT GGC CCT AAT GTT TTT 483Ser Val Thr Lys Gly Gly Glu Ser Val Arg Tyr Gly Pro Asn Val Phe
145 150 155GGC GGT GTG ATT AAT GTG ATC ACT AAG GGC ATT CCT ACC AAG TGG GAG 531Gly Gly Val Ile Asn Val Ile Thr Lys Gly Ile Pro Thr Lys Trp Glu
160 165 170AGT CAG GTG AGC GAG AGG GCC ACT TTT TGG GGC AAA TCT GAA AAT GGG 579Ser Gln Val Ser Glu Arg Ala Thr Phe Trp Gly Lys Ser Glu Asn Gly
175 180 185GGC TTT TTC AAT CAA AAT TCT AAA AAC CTT GAC AAA AGC TTA GCC AAT 627Gly Phe Phe Asn Gln Asn Ser Lys Asn Leu Asp Lys Ser Leu Ala Asn190 195 200 205AAC ATG CTT TTT GAC ACT TAC TTA AGA ACA GGG GGC ATG ATG AAT AAG 675Asn Met Leu Phe Asp Thr Tyr Leu Arg Thr Gly Gly Met Met Asn Lys
210 215 220CAT TTT GGA ATC CAA GCT CAA GCC AAC TGG CTT AAA GGG CAA GGG TTT 723His Phe Gly Ile Gln Ala Gln Ala Asn Trp Leu Lys Gly Gln Gly Phe
225 230 235AGA TAC AAC AGC CCT ACG AAC ATT CAA AAC TAC ATG CTA GAT TCC TTG 771Arg Tyr Asn Ser Pro Thr Asn Ile Gln Asn Tyr Met Leu Asp Ser Leu
240 245 250TAT CAA ATT AAT GAT AGT AAT AAG ATC ACT GCT TTT TTC CAA TAC TAT 819Tyr Gln Ile Asn Asp Ser Asn Lys Ile Thr Ala Phe Phe Gln Tyr Tyr
255 260 265AAT TAT TTT ATG GCA GAC CCC GGA TCT TTA GGC ATA GAA GCG TAT AAT 867Asn Tyr Phe Met Ala Asp Pro Gly Ser Leu Gly Ile Glu Ala Tyr Asn270 275 280 285CAA AAT CGT TTT CAA AAC AAC CGC CCT AAT AAC AAT AAA AGC GGG AGA 915Gln Asn Arg Phe Gln Asn Asn Arg Pro Asn Asn Asn Lys Ser Gly Arg
290 295 300GCG AAG CGR TGG GGA GCT GTG TAT CAA AAC TTT TTT GGG GAT ACG GAC 963Ala Lys Xaa Trp Gly Ala Val Tyr Gln Asn Phe Phe Gly Asp Thr Asp
305 310 315AAA ATA GGT GGG GAT TTC ACT TTT AGT TAC TAT GGG CAT GAC ATG TCA 1011Lys Ile Gly Gly Asp Phe Thr Phe Ser Tyr Tyr Gly His Asp Met Ser
320 325 330AGG GAT TTT CAA TTT GAT TCT AAT TTT TTG AAT GTC AAT ACC AAT CCT 1059Arg Asp Phe Gln Phe Asp Ser Asn Phe Leu Asn Val Asn Thr Asn Pro
335 340 345AAA TTA GGC CCT GTT TAT ACC GAT CAA AAT TAT CCA GGA TTT TTT ATT 1107Lys Leu Gly Pro Val Tyr Thr Asp Gln Asn Tyr Pro Gly Phe Phe Ile350 355 360 365TTT GAT CAT TTA AGG CGT TAC ATA ATG AAC GCT TTT GAG CCT AAT TTG 1155Phe Asp His Leu Arg Arg Tyr Ile Met Asn Ala Phe Glu Pro Asn Leu
370 375 380AAC TTA GTT GTC AAT ACC AAT AAA GTT AAG CAA ACT TTT AAT GTG GGC 1203Asn Leu Val Val Asn Thr Asn Lys Val Lys Gln Thr Phe Asn Val Gly
385 390 395ATG CGT TTT ATG ACA ATG GAT ATG TAT TTC AGA TTG GAT CAA AGC ACA 1251Met Arg Phe Met Thr Met Asp Met Tyr Phe Arg Leu Asp Gln Ser Thr
400 405 410TGC GAA AAA ACC GAT ATT TTT AAT GGG GTG TGC CGC ATG CCT CCT TTT 1299Cys Glu Lys Thr Asp Ile Phe Asn Gly Val Cys Arg Met Pro Pro Phe
415 420 425GTT CTT TCT AAA AAA CCC AGC AAC AAT CAA AAC CTG TTT AAC AAC TAT 1347Val Leu Ser Lys Lys Pro Ser Asn Asn Gln Asn Leu Phe Asn Asn Tyr430 435 440 445ACA GCG GTA TGG TTG AGC GAT AAA ATA GAG CTT TTT GAT TCT AAA TTG 1395Thr Ala Val Trp Leu Ser Asp Lys Ile Glu Leu Phe Asp Ser Lys Leu
450 455 460GTG ATA ACT CCA GGG CTT AGA TAC ACTTTT TTG AAC TAT AAC AAC AAA 1443Val Ile Thr Pro Gly Leu Arg Tyr Thr Phe Leu Asn Tyr Asn Asn Lys
465 470 475GAG CCA GAA AAG CAT GAT TTT TCT GTG TGG AAT ATT ACA AAA AAG CGT 1491Glu Pro Glu Lys His Asp Phe Ser Val Trp Asn Ile Thr Lys Lys Arg
480 485 490CAA AAC GAA TGG AGT CCC GCC CTT AAC ATT GGC TAT AAA CCT ATG GAA 1539Gln Asn Glu Trp Ser Pro Ala Leu Asn Ile Gly Tyr Lys Pro Met Glu
495 500 505AAT TGG ATA TGG TAT GCG AAC TAC CGC CGC AGT TTT ATC CCC CCA CAA 1587Asn Trp Ile Trp Tyr Ala Asn Tyr Arg Arg Ser Phe Ile Pro Pro Gln510 515 520 525CAT ACA ATG CTA GGC ATT ACT AGG ACT AAT TAC AAC CAA ATT TTT AAT 1635His Thr Met Leu Gly Ile Thr Arg Thr Asn Tyr Asn Gln Ile Phe Asn
530 535 540GAA ATT GAA GTG GGG CAA CGC TAT AGT TAT AAA AAT CTA TTG AGC TTT 1683Glu Ile Glu Val Gly Gln Arg Tyr Ser Tyr Lys Asn Leu Leu Ser Phe
545 550 555AAC ACG AAT TAT TTT GTG ATT TTT GCC AAG CGT TAC TAT GCG GGA GGC 1731Asn Thr Asn Tyr Phe Val Ile Phe Ala Lys Arg Tyr Tyr Ala Gly Gly
560 565 570TAT AGC CCA CAG CCT ATT AAC GCT AGG AGT CAA GGG GTA GAA TTG GAA 1779Tyr Ser Pro Gln Pro Ile Asn Ala Arg Ser Gln Gly Val Glu Leu Glu
575 580 585TTG TAT TAC GCG CCG ATT AGG GGT TTG CAA TTC CAT GTG GCT TAC ACC 1827Leu Tyr Tyr Ala Pro Ile Arg Gly Leu Gln Phe His Val Ala Tyr Thr590 595 600 605TAT ATT GAT GCA CGC ATC ACT TCT AAC GCT GAT GAT ATT GCT TAT TAT 1875Tyr Ile Asp Ala Arg Ile Thr Ser Asn Ala Asp Asp Ile Ala Tyr Tyr
610 615 620TTT ACA GGC ATT GTC AAT AAA CCC TTT GAC ATT AAA GGG AAG CGT TTG 1923Phe Thr Gly Ile Val Asn Lys Pro Phe Asp Ile Lys Gly Lys Arg Leu
625 630 635CCT TAT GTG AGT CCT AAC CAA TTC ATA TTT GAC ATG ATG TAT ACT TAC 1971Pro Tyr Val Ser Pro Asn Gln Phe Ile Phe Asp Met Met Tyr Thr Tyr
640 645 650AAG CAC ACG ACT TTT GGT ATT AGC AGC TAT TTT TAT AGC CGT GCT TAT 2019Lys His Thr Thr Phe Gly Ile Ser Ser Tyr Phe Tyr Ser Arg Ala Tyr
655 660 665AGT TCT ATG CTC AAT CAG GCC AAA AGC CAA ACC GTG TGC CTG CCC TTA 2067Ser Ser Met Leu Asn Gln Ala Lys Ser Gln Thr Val Cys Leu Pro Leu670 675 680 685AAC CCA GAA TAC ACA GGG GGG CTA GAG TAT GGT TGT AAT TCA GTA GGG 2115Asn Pro Glu Tyr Thr Gly Gly Leu Glu Tyr Gly Cys Asn Ser Val Gly
690 695 700TTA TTG CCC TTG TAT TTT GTG TTG AAC GTT CAA GTA AGC TCG GTT TTA 2163Leu Leu Pro Leu Tyr Phe Val Leu Asn Val Gln Val Ser Ser Val Leu
705 710 715TGG CAA AGC GGT AGG CAT AAA ATC ACA GGG AGT TTG CAA ATC AAT AAT 2211Trp Gln Ser Gly Arg His Lys Ile Thr Gly Ser Leu Gln Ile Asn Asn
720 725 730CTT TTT AAC ATG AAG TAT TAT TTT AGG GGA ATT GGC ACA AGC CCT ACA 2259Leu Phe Asn Met Lys Tyr Tyr Phe Arg Gly Ile Gly Thr Ser Pro Thr
735 740 745GGA AGA GAG CCC GCA CCA GGG CGA TCC ATT ACA GCG TAT TTG AAT TAT 2307Gly Arg Glu Pro Ala Pro Gly Arg Ser Ile Thr Ala Tyr Leu Asn Tyr750 755 760 765GAG TTTTAAACTAGCT TCAAGCTTTT ATCGCTTGAA TGCTTGTTA 2352Glu Phe
(2) Sequence 812 data:
(i) sequence characteristics:
(A) length: 767 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 812: met Lys Arg Ile Leu Val Ser Leu Ala Val Leu Ser His Ser Ala His 151015 Ala Val Lys Thr His Asn Leu Glu Arg Val Glu Ala Ser Gly Val Ala
20 25 30Asn Asp Lys Glu Ala Pro Leu Ser Trp Arg Ser Lys Glu Val Arg Asn
35 40 45Tyr Met Gly Ser Arg Thr Val Ile Ser Asn Lys Gln Leu Thr Lys Ser
50 55 60Ala Asn Gln Ser Ile Glu Glu Ala Leu Gln Asn Val Pro Gly Val His65 70 75 80Ile Arg Asn Ala Thr Gly Ile Gly Ala Val Pro Ser Phe Ser Val Arg
85 90 95Gly Phe Gly Gly Gly Ser Ser Gly His Ser Asn Thr Ala Met Val Leu
100 105 110Val Asn Gly Ile Pro Ile Tyr Val Ala Pro Tyr Val Asp Ile Ser Ile
115 120 125Pro Ile Phe Pro Val Thr Phe Gln Ser Val Asp Arg Ile Ser Val Thr
130 135 140Lys Gly Gly Glu Ser Val Arg Tyr Gly Pro Asn Val Phe Gly Gly Val145 150 155 160Ile Asn Val Ile Thr Lys Gly Ile Pro Thr Lys Trp Glu Ser Gln Val
165 170 175Ser Glu Arg Ala Thr Phe Trp Gly Lys Ser Glu Asn Gly Gly Phe Phe
180 185 190Asn Gln Asn Ser Lys Asn Leu Asp Lys Ser Leu Ala Asn Asn Met Leu
195 200 205Phe Asp Thr Tyr Leu Arg Thr Gly Gly Met Met Asn Lys His Phe Gly
210 215 220Ile Gln Ala Gln Ala Asn Trp Leu Lys Gly Gln Gly Phe Arg Tyr Asn225 230 235 240Ser Pro Thr Asn Ile Gln Asn Tyr Met Leu Asp Ser Leu Tyr Gln Ile
245 250 255Asn Asp Ser Asn Lys Ile Thr Ala Phe Phe Gln Tyr Tyr Asn Tyr Phe
260 265 270Met Ala Asp Pro Gly Ser Leu Gly Ile Glu Ala Tyr Asn Gln Asn Arg
275 280 285Phe Gln Asn Asn Arg Pro Asn Asn Asn Lys Ser Gly Arg Ala Lys Xaa
290 295 300Trp Gly Ala Val Tyr Gln Asn Phe Phe Gly Asp Thr Asp Lys Ile Gly305 310 315 320Gly Asp Phe Thr Phe Ser Tyr Tyr Gly His Asp Met Ser Arg Asp Phe
325 330 335Gln Phe Asp Ser Asn Phe Leu Asn Val Asn Thr Asn Pro Lys Leu Gly
340 345 350Pro Val Tyr Thr Asp Gln Asn Tyr Pro Gly Phe Phe Ile Phe Asp His
355 360 365Leu Arg Arg Tyr Ile Met Asn Ala Phe Glu Pro Asn Leu Asn Leu Val
370 375 380Val Asn ThrAsn Lys Val Lys Gln Thr Phe Asn Val Gly Met Arg Phe385 390 395 400Met Thr Met Asp Met Tyr Phe Arg Leu Asp Gln Ser Thr Cys Glu Lys
405 410 415Thr Asp Ile Phe Asn Gly Val Cys Arg Met Pro Pro Phe Val Leu Ser
420 425 430Lys Lys Pro Ser Asn Asn Gln Asn Leu Phe Asn Asn Tyr Thr Ala Val
435 440 445Trp Leu Ser Asp Lys Ile Glu Leu Phe Asp Ser Lys Leu Val Ile Thr
450 455 460Pro Gly Leu Arg Tyr Thr Phe Leu Asn Tyr Asn Asn Lys Glu Pro Glu465 470 475 480Lys His Asp Phe Ser Val Trp Asn Ile Thr Lys Lys Arg Gln Asn Glu
485 490 495Trp Ser Pro Ala Leu Asn Ile Gly Tyr Lys Pro Met Glu Asn Trp Ile
500 505 510Trp Tyr Ala Asn Tyr Arg Arg Ser Phe Ile Pro Pro Gln His Thr Met
515 520 525Leu Gly Ile Thr Arg Thr Asn Tyr Asn Gln Ile Phe Asn Glu Ile Glu
530 535 540Val Gly Gln Arg Tyr Ser Tyr Lys Asn Leu Leu Ser Phe Asn Thr Asn545 550 555 560Tyr Phe Val Ile Phe Ala Lys Arg Tyr Tyr Ala Gly Gly Tyr Ser Pro
565 570 575Gln Pro Ile Asn Ala Arg Ser Gln Gly Val Glu Leu Glu Leu Tyr Tyr
580 585 590Ala Pro Ile Arg Gly Leu Gln Phe His Val Ala Tyr Thr Tyr Ile Asp
595 600 605Ala Arg Ile Thr Ser Asn Ala Asp Asp Ile Ala Tyr Tyr Phe Thr Gly
610 615 620Ile Val Asn Lys Pro Phe Asp Ile Lys Gly Lys Arg Leu Pro Tyr Val625 630 635 640Ser Pro Asn Gln Phe Ile Phe Asp Met Met Tyr Thr Tyr Lys His Thr
645 650 655Thr Phe Gly Ile Ser Sar Tyr Phe Tyr Ser Arg Ala Tyr Ser Ser Met
660 665 670Leu Asn Gln Ala Lys Ser Gln Thr Val Cys Leu Pro Leu Asn Pro Glu
675 680 685Tyr Thr Gly Gly Leu Glu Tyr Gly Cys Asn Ser Val Gly Leu Leu Pro
690 695 700Leu Tyr Phe Val Leu Asn Val Gln Val Ser Ser Val Leu Trp Gln Ser705 710 715 720Gly Arg His Lys Ile Thr Gly Ser Leu Gln Ile Asn Asn Leu Phe Asn
725 730 735Met Lys Tyr Tyr Phe Arg Gly Ile Gly Thr Ser Pro Thr Gly Arg Glu
740 745 750Pro Ala Pro Gly Arg Ser Ile Thr Ala Tyr Leu Asn Tyr Glu Phe
755 760 765
(2) Data in sequence 813:
(i) sequence characteristics:
(A) length: 888bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...837
(D) Other information:
(xi) Description of the sequence: sequence 813: AGATAGGAAT GTAAAGGA ATG GAA TTT ATG AAA AAG TTT GTA GCT TTA GGG 51
Met Glu Phe Met Lys Lys Phe Val Ala Leu Gly
1 5 10CTT CTA TCC GCA GTT TTA AGC TCT TCG TTG TTA GCC GAA GGT GAT GGT 99Leu Leu Ser Ala Val Leu Ser Ser Ser Leu Leu Ala Glu Gly Asp Gly
15 20 25GTT TAT ATA GGG ACT AAT TAT CAG CTT GGA CAA GCC CGT TTG AAT AGT 147Val Tyr Ile Gly Thr Asn Tyr Gln Leu Gly Gln Ala Arg Leu Asn Ser
30 35 40AAT ATT TAT AAT ACA GGG GAT TGC ACA GGG AGT GTT GTA GGT TGC CCC 195Asn Ile Tyr Asn Thr Gly Asp Cys Thr Gly Ser Val Val Gly Cys Pro
45 50 55CCA GGT CTT ACC GCT AAT AAG CAT AAT CCA GGA GGC ACC AAT ATC AAT 243Pro Gly Leu Thr Ala Asn Lys His Asn Pro Gly Gly Thr Asn Ile Asn60 65 70 75TGG CAT GCT AAA TAC GCT AAT GGG GCT TTG AAT GGT CTT GGG TTG AAT 291Trp His Ala Lys Tyr Ala Asn Gly Ala Leu Asn Gly Leu Gly Leu Asn
80 85 90GTG GGT TAT AAG AAG TTC TTC CAG TTC AAG TCT TTT GAT ATG ACA AGC 339Val Gly Tyr Lys Lys Phe Phe Gln Phe Lys Ser Phe Asp Met Thr Ser
95 100 105AAG TGG TTT GGT TTT AGA GTG TAT GGG CTT TTT GAT TAT GGG CAT GCC 387Lys Trp Phe Gly Phe Arg Val Tyr Gly Leu Phe Asp Tyr Gly His Ala
110 115 120ACT TTA GGC AAG CAA GTT TAT GCA CCT AAT AAA ATC CAG TTG GAT ATG 435Thr Leu Gly Lys Gln Val Tyr Ala Pro Asn Lys Ile Gln Leu Asp Met
125 130 135GTC TCT TGG GGT GTG GGG AGC GAT TTG TTA GCT GAT ATT ATT GAT AAC 483Val Ser Trp Gly Val Gly Ser Asp Leu Leu Ala Asp Ile Ile Asp Asn140 145 150 155GAT AAC GCT TCT TTT GGT ATT TTT GGT GGG GTC GCT ATC GGC GGT AAC 531Asp Asn Ala Ser Phe Gly Ile Phe Gly Gly Val Ala Ile Gly Gly Asn
160 165 170ACT TGG AAA AGC TCA GCG GCA AAC TAT TGG AAA GAG CAA ATC ATT GAA 579Thr Trp Lys Ser Ser Ala Ala Asn Tyr Trp Lys Glu Gln Ile Ile Glu
175 180 185GCT AAG GGT CCT GAT GTT TGT ACC CCT ACT TAT TGT AAC CCT AAC GCT 627Ala Lys Gly Pro Asp Val Cys Thr Pro Thr Tyr Cys Asn Pro Asn Ala
190 195 200CCT TAT AGC ACC AAA ACT TCA ACC GTC GCT TTT CAG GTA TGG TTG AAT 675Pro Tyr Ser Thr Lys Thr Ser Thr Val Ala Phe Gln Val Trp Leu Asn
205 210 215TTT GGG GTG AGA GCC AAT ATT TAC AAG CAT AAT GGC GTA GAG TTT GGC 723Phe Gly Val Arg Ala Asn Ile Tyr Lys His Asn Gly Val Glu Phe Gly220 225 230 235GTG AGA GTG CCG CTA CTC ATC AAC AAG TTT TTG AGT GCG GGT CCT AAC 771Val Arg Val Pro Leu Leu Ile Asn Lys Phe Leu Ser Ala Gly Pro Asn
240 245 250GCT ACT AAT CTT TAT TAC CAT TTG AAA CGG GAT TAT TCG CTT TAT TTA 819Ala Thr Asn Leu Tyr Tyr His Leu Lys Arg Asp Tyr Ser Leu Tyr Leu
255 260 265GGG TAT AAC TAC ACT TTT TAAACCCTTT AAAAGGGTGT CTTTAAGCCC TTTTTAGT 875Gly Tyr Asn Tyr Thr Phe
270CCTTATAAAA AGG 888
(2) Sequence 814 data:
(i) sequence characteristics:
(A) length: 273 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 814: met Glu Phe Met Lys Lys Phe Val Ala Leu Gly Leu Leu Ser Ala Val 151015 Leu Ser Ser Ser Leu Leu Ala Glu Gly Asp Gly Val Tyr Ile Gly Thr
20 25 30Asn Tyr Gln Leu Gly Gln Ala Arg Leu Asn Ser Asn Ile Tyr Asn Thr
35 40 45Gly Asp Cys Thr Gly Ser Val Val Gly Cys Pro Pro Gly Leu Thr Ala
50 55 60Asn Lys His Asn Pro Gly Gly Thr Asn Ile Asn Trp His Ala Lys Tyr65 70 75 80Ala Asn Gly Ala Leu Asn Gly Leu Gly Leu Asn Val Gly Tyr Lys Lys
85 90 95Phe Phe Gln Phe Lys Ser Phe Asp Met Thr Ser Lys Trp Phe Gly Phe
100 105 110Arg Val Tyr Gly Leu Phe Asp Tyr Gly His Ala Thr Leu Gly Lys Gln
115 120 125Val Tyr Ala Pro Asn Lys Ile Gln Leu Asp Met Val Ser Trp Gly Val
130 135 140Gly Ser Asp Leu Leu Ala Asp Ile Ile Asp Asn Asp Asn Ala Ser Phe145 150 155 160Gly Ile Phe Gly Gly Val Ala Ile Gly Gly Asn Thr Trp Lys Ser Ser
165 170 175Ala Ala Asn Tyr Trp Lys Glu Gln Ile Ile Glu Ala Lys Gly Pro Asp
180 185 190Val Cys Thr Pro Thr Tyr Cys Asn Pro Asn Ala Pro Tyr Ser Thr Lys
195 200 205Thr Ser Thr Val Ala Phe Gln Val Trp Leu Asn Phe Gly Val Arg Ala
210 215 220Asn Ile Tyr Lys His Asn Gly Val Glu Phe Gly Val Arg Val Pro Leu225 230 235 240Leu Ile Asn Lys Phe Leu Ser Ala Gly Pro Asn Ala Thr Asn Leu Tyr
245 250 255Tyr His Leu Lys Arg Asp Tyr Ser Leu Tyr Leu Gly Tyr Asn Tyr Thr
260 265 270Phe
(2) Sequence 815 data:
(i) sequence characteristics:
(A) length: 560bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 37...522
(D) Other information:
(xi) Description of the sequence: sequence 815: CACGGTCATT TTGTCTGTGT TTTTAGTCGC GTATTC ATG CAA CTG CTT ATG GAA 54
Met Gln Leu Leu Met Glu
15CGC CTT TCT CTT GTC TTC AGG CAT CTT TTC CAT GCG CTT TTT CAA CTC 102Arg Leu Ser Leu Val Phe Arg His Leu Phe His Ala Leu Phe Gln Leu
10 15 20TTT TGT GTA ATC CAC AAT ATC CTG CGG AGK ACA ACG CCA GCC ATT TTA 150Phe Cys Val Ile His Asn Ile Leu Arg Xaa Thr Thr Pro Ala Ile Leu
25 30 35GCC AAA TCT TCA TCG CTT GTT TTG CTG AAA TCT TTG GCG TTC AAA GCC 198Ala Lys Ser Ser Ser Leu Val Leu Leu Lys Ser Leu Ala Phe Lys Ala
40 45 50ACA AAT AGC AAC GCG CTA ACA GAA AGT ATT TTC AAC GCT TTT TTC ATT 246Thr Asn Ser Asn Ala Leu Thr Glu Ser Ile Phe Asn Ala Phe Phe Ile55 60 65 70TTT TAT CCT TTT AAA TTA AAT TTA TCT CAC TTA GGA GAG CAA TGC TCG 294Phe Tyr Pro Phe Lys Leu Asn Leu Ser His Leu Gly Glu Gln Cys Ser
75 80 85TCT TTT TTC TTA ACA GCC CTA CAC CAA ACT TTT CTC GTA TCG CCG CTG 342Ser Phe Phe Leu Thr Ala Leu His Gln Thr Phe Leu Val Ser Pro Leu
90 95 100CAA ACG CTC ACA TTA AGT CCT TTT GCC TTG ATT TCT TCA TCG CTC AAA 390Gln Thr Leu Thr Leu Ser Pro Phe Ala Leu Ile Ser Ser Ser Leu Lys
105 110 115CCT TTG GTT TTT TCT TCT AAT TCT TTA CGC ACT TCT TCA CGC ATT TTT 438Pro Leu Val Phe Ser Ser Asn Ser Leu Arg Thr Ser Ser Arg Ile Phe
120 125 130TTG AAA TCC TTC GCT CAT TTT GGA AAG ATT CTT CCT AGC GAT CCG GCT 486Leu Lys Ser Phe Ala His Phe Gly Lys Ile Leu Pro Ser Asp Pro Ala135 140 145 150GAA ATT CGC GCG GAA TTT CTT AGC GTC CTC AGC GTT TAAAGTTTTA AGGCGT 538Glu Ile Arg Ala Glu Phe Leu Ser Val Leu Ser Val
155 160TTAGACACTT CCATGCGATA AT 560
(2) Sequence 816 data:
(i) sequence characteristics:
(A) length: 162 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 816: met Gln Leu Leu Met Glu Arg Leu Ser Leu Val Phe Arg His Leu Phe 151015 His Ala Leu Phe Gln Leu Phe Cys Val Ile His Asn Ile Leu Arg Xaa
20 25 30Thr Thr Pro Ala Ile Leu Ala Lys Ser Ser Ser Leu Val Leu Leu Lys
35 40 45Ser Leu Ala Phe Lys Ala Thr Asn Ser Asn Ala Leu Thr Glu Ser Ile
50 55 60Phe Asn Ala Phe Phe Ile Phe Tyr Pro Phe Lys Leu Asn Leu Ser His65 70 75 80Leu Gly Glu Gln Cys Ser Ser Phe Phe Leu Thr Ala Leu His Gln Thr
85 90 95Phe Leu Val Ser Pro Leu Gln Thr Leu Thr Leu Ser Pro Phe Ala Leu
100 105 110Ile Ser Ser Ser Leu Lys Pro Leu Val Phe Ser Ser Asn Ser Leu Arg
115 120 125Thr Ser Ser Arg Ile Phe Leu Lys Ser Phe Ala His Phe Gly Lys Ile
130 135 140Leu Pro Ser Asp Pro Ala Glu Ile Arg Ala Glu Phe Leu SerVal Leu145 150 155 160Ser Val
(2) Sequence 817 materials:
(i) sequence characteristics:
(A) length: 1196bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 41...1132
(D) Other information:
(xi) Description of the sequence: sequence 817: AAGGCATCCA CCATTAACCC TTTTTAAATT TATTTTAACG ATG TTT TAC TAT ACT 55
Met Phe Tyr Tyr Thr
1 5ATA AAA TCT TTT AAT TTC AAA AGG TGG TCC ATA ATG AGA ATA TTT TTG 103Ile Lys Ser Phe Asn Phe Lys Arg Trp Ser Ile Met Arg Ile Phe Leu
10 15 20AAA TTG TTG ATT CTT TTA TTT TGT TTG AAG GGG CAG GTT ATG GCT CAA 151Lys Leu Leu Ile Leu Leu Phe Cys Leu Lys Gly Gln Val Met Ala Gln
25 30 35AAT TTA CCC ACC ATT GCT TTA CTG GCG ACA GGG GGG ACG ATT GCA GGG 199Asn Leu Pro Thr Ile Ala Leu Leu Ala Thr Gly Gly Thr Ile Ala Gly
40 45 50AGT GGT GCG AGC GCG AGT TTG GGT AGT TAT AAG AGT GGT GAG TTG GGC 247Ser Gly Ala Ser Ala Ser Leu Gly Ser Tyr Lys Ser Gly Glu Leu Gly
55 6065ATC AAA GAG CTT TTG AAG GCT ATC CCT AGT CTT AAC AGA CTC GCT CGC 295Ile Lys Glu Leu Leu Lys Ala Ile Pro Ser Leu Asn Arg Leu Ala Arg70 75 80 85ATT CAA GGG GAG CAG ATT TCT AAC ATC GGC TCA CAA GAC ATG AAT GAA 343Ile Gln Gly Glu Gln Ile Ser Asn Ile Gly Ser Gln Asp Met Asn Glu
90 95 100GAG GTA TGG TTC AAG CTC GCC AAA CGT GCC CAA GAA TTG CTA GAT GAT 391Glu Val Trp Phe Lys Leu Ala Lys Arg Ala Gln Glu Leu Leu Asp Asp
105 110 115AGC CGT ATT CAA GGC GTG GTC ATC ACG CAT GGC ACG GAC ACT TTA GAA 439Ser Arg Ile Gln Gly Val Val Ile Thr His Gly Thr Asp Thr Leu Glu
120 125 130GAG AGC GCG TAT TTT TTA AAC TTA GTT TTA CGC TCC ACA AAA CCG GTC 487Glu Ser Ala Tyr Phe Leu Asn Leu Val Leu Arg Ser Thr Lys Pro Val
135 140 145GTG CTG GTG GGA GCG ATG CGT AAT GCT GCT TCT TTG AGC GCG GAT GGG 535Val Leu Val Gly Ala Met Arg Asn Ala Ala Ser Leu Ser Ala Asp Gly150 155 160 165GCT TTG AAT TTA TAT AAT GCT GTG AGC GTA GCG CTC AAT GAA AAA AGT 583Ala Leu Asn Leu Tyr Asn Ala Val Ser Val Ala Leu Asn Glu Lys Ser
170 175 180GCG AAT AAA GGC GTG TTA GTG GTG ATG GAC GAT AAT ATT TTT AGC GCT 631Ala Asn Lys Gly Val Leu Val Val Met Asp Asp Asn Ile Phe Ser Ala
185 190 195AGA GAA GTG ATT AAA ACG CAC ACC ACC CAC ACT TCC ACC TTT AAA GCC 679Arg Glu Val Ile Lys Thr His Thr Thr His Thr Ser Thr Phe Lys Ala
200 205 210TTA AAT AGC GGC GCG ATA GGG AGC GTG TAT TAT GGC AAA ACG CGC TAT 727Leu Asn Ser Gly Ala Ile Gly Ser Val Tyr Tyr Gly Lys Thr Arg Tyr
215 220 225TAC ATG CAG CCT TTG AGA AAA CAC ACC ACA GAG AGC GAA TTT TCC CTT 775Tyr Met Gln Pro Leu Arg Lys His Thr Thr Glu Ser Glu Phe Ser Leu230 235 240 245TCA CAA CTC AAA ACC CCC CTG CCT AAA GTG GAT ATT ATT TAC ACG CAT 823Ser Gln Leu Lys Thr Pro Leu Pro Lys Val Asp Ile Ile Tyr Thr His
250 255 260GCT GGC ATG ACC CCT GAT TTA TTC CAA GCG AGC CTA AAC TCG CAT GCA 871Ala Gly Met Thr Pro Asp Leu Phe Gln Ala Ser Leu Asn Ser His Ala
265 270 275AAA GGC GTT GTG ATA GCC GGG GTG GGT AAT GGG AAT GTG AGC GCT GGG 919Lys Gly Val Val Ile Ala Gly Val Gly Asn Gly Asn Val Ser Ala Gly
280 285 290TTT TTA AAA GCG ATG CAA GAA GCG AGC CAA ATG GGG GTG GTT ATT GTT 967Phe Leu Lys Ala Met Gln Glu Ala Ser Gln Met Gly Val Val Ile Val
295 300 305CGT TCT AGC AGG GTA AAT AGC GGT GAG ATT ACT TCA GGC GAG ATT GAT 1015Arg Ser Ser Arg Val Asn Ser Gly Glu Ile Thr Ser Gly Glu Ile Asp310 315 320 325GAC AAG GCC TTC ATC ACA AGC GAC AAT TTA AAC CCC CAA AAA GCT AGG 1063Asp Lys Ala Phe Ile Thr Ser Asp Asn Leu Asn Pro Gln Lys Ala Arg
330 335 340GTG CTT TTA CAA CTC GCT TTA ACT AAA ACA AAT AAT AAA GAA AAA ATC 1111Val Leu Leu Gln Leu Ala Leu Thr Lys Thr Asn Asn Lys Glu Lys Ile
345 350 355CAA GAA ATG TTT GAA GAG TAT TGAAAGATTC TCTTAAATCA CCCAATTATC AAAG 1166Gln Glu Met Phe Glu Glu Tyr
360ATAATTGGGT GATTTGGTTT ATTTTGTTTT 1196
(2) Sequence 818 data:
(i) sequence characteristics:
(A) length: 364 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 818: met Phe Tyr Tyr Thr Ile Lys Ser Phe Asn Phe Lys Arg Trp Ser Ile 151015 Met Arg Ile Phe Leu Lys Leu Leu Ile Leu Leu Phe Cys Leu Lys Gly
20 25 30Gln Val Met Ala Gln Asn Leu Pro Thr Ile Ala Leu Leu Ala Thr Gly
35 40 45Gly Thr Ile Ala Gly Ser Gly Ala Ser Ala Ser Leu Gly Ser Tyr Lys
50 55 60Ser Gly Glu Leu Gly Ile Lys Glu Leu Leu Lys Ala Ile Pro Ser Leu65 70 75 80Asn Arg Leu Ala Arg Ile Gln Gly Glu Gln Ile Ser Asn Ile Gly Ser
85 90 95Gln Asp Met Asn Glu Glu Val Trp Phe Lys Leu Ala Lys Arg Ala Gln
100 105 110Glu Leu Leu Asp Asp Ser Arg Ile Gln Gly Val Val Ile Thr His Gly
115 120 125Thr Asp Thr Leu Glu Glu Ser Ala Tyr Phe Leu Asn Leu Val Leu Arg
130 135 140Ser Thr Lys Pro Val Val Leu Val Gly Ala Met Arg Asn Ala Ala Ser145 150 155 160Leu Ser Ala Asp Gly Ala Leu Asn Leu Tyr Asn Ala Val SerVal Ala
165 170 175Leu Asn Glu Lys Ser Ala Asn Lys Gly Val Leu Val Val Met Asp Asp
180 185 190Asn Ile Phe Ser Ala Arg Glu Val Ile Lys Thr His Thr Thr His Thr
195 200 205Ser Thr Phe Lys Ala Leu Asn Ser Gly Ala Ile Gly Ser Val Tyr Tyr
210 215 220Gly Lys Thr Arg Tyr Tyr Met Gln Pro Leu Arg Lys His Thr Thr Glu225 230 235 240Ser Glu Phe Ser Leu Ser Gln Leu Lys Thr Pro Leu Pro Lys Val Asp
245 250 255Ile Ile Tyr Thr His Ala Gly Met Thr Pro Asp Leu Phe Gln Ala Ser
260 265 270Leu Asn Ser His Ala Lys Gly Val Val Ile Ala Gly Val Gly Asn Gly
275 280 285Asn Val Ser Ala Gly Phe Leu Lys Ala Met Gln Glu Ala Ser Gln Met
290 295 300Gly Val Val Ile Val Arg Ser Ser Arg Val Asn Ser Gly Glu Ile Thr305 310 315 320Ser Gly Glu Ile Asp Asp Lys Ala Phe Ile Thr Ser Asp Asn Leu Asn
325 330 335Pro Gln Lys Ala Arg Val Leu Leu Gln Leu Ala Leu Thr Lys Thr Asn
340 345 350Asn Lys Glu Lys Ile Gln Glu Met Phe Glu Glu Tyr
355 360
(2) Sequence 819 data:
(i) sequence characteristics:
(A) length: 678bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 37...612
(D) Other information:
(xi) Description of the sequence: sequence 819: AGTAAAACAT CGTTAAAATA AATTTAAAAA GGGTTA ATG GTG GAT GCC TTT TTC 54
Met Val Asp Ala Phe Phe
1 5CAA ATT GCA GTG TTA CTT TTT TCG CTT TTT TTA GGG GCA AGG CTA GGG 102Gln Ile Ala Val Leu Leu Phe Ser Leu Phe Leu Gly Ala Arg Leu Gly
10 15 20GGC TTG GGA GTG GGC TAT GCG GGG GGC TTG GGC GTG CTT ATT TTA TGC 150Gly Leu Gly Val Gly Tyr Ala Gly Gly Leu Gly Val Leu Ile Leu Cys
25 30 35TTA TTT TTG GGG CTA AAT CCG GGC AAA ATC CCT TTT GAT GTG ATT TTA 198Leu Phe Leu Gly Leu Asn Pro Gly Lys Ile Pro Phe Asp Val Ile Leu
40 45 50ATC ATC ATG GCA GTC ATT AGC GCT ATT AGC GCG ATG CAA AAA GCG GGG 246Ile Ile Met Ala Val Ile Ser Ala Ile Ser Ala Met Gln Lys Ala Gly55 60 65 70GGC TTG GAT TAC TTA GTC AAA ATC GCT GAA AAA ATT TTA AGG AAA CAC 294Gly Leu Asp Tyr Leu Val Lys Ile Ala Glu Lys Ile Leu Arg Lys His
75 80 85CCC AAG CAA ATC AAT TAC CTT GCG CCA AGC GTG GCG TAT TGT TTA ACG 342Pro Lys Gln Ile Asn Tyr Leu Ala Pro Ser Val AlaTyr Cys Leu Thr
90 95 100ATA CTA GCC GGC ACC GGG CAT ACG GTT TTT TCC TTG ATC CCG GTG ATT 390Ile Leu Ala Gly Thr Gly His Thr Val Phe Ser Leu Ile Pro Val Ile
105 110 115GTG GAA GTG AGC CAG AGC CAA AAC ATC AAG CCT AAA GCG CCT TTA AGC 438Val Glu Val Ser Gln Ser Gln Asn Ile Lys Pro Lys Ala Pro Leu Ser
120 125 130TTA GCG GTA GTC TCT AGT CAA GTC GCT ATT ACT GCA AGC CCG GTG AGC 486Leu Ala Val Val Ser Ser Gln Val Ala Ile Thr Ala Ser Pro Val Ser135 140 145 150GCA GCG GTN GGT GTT TAT GAG CGG CAT TTT AGA GCC TTT AGG AGC AAA 534Ala Ala Xaa Gly Val Tyr Glu Arg His Phe Arg Ala Phe Arg Ser Lys
155 160 165TTA CTT GAC CCT TTT AAT GGT TTG GAT CCC TAC GAC TTT TTT AGC ATG 582Leu Leu Asp Pro Phe Asn Gly Leu Asp Pro Tyr Asp Phe Phe Ser Met
170 175 180CAT GCT CAC GGC ATT TAT TAT GGG TTT TAC TGATTTGAAA TTAGACAGCG ATC 635His Ala His Gly Ile Tyr Tyr Gly Phe Tyr
185 190CGCATTATTT AGAGCGCTTG AAAGCGGGCA AAATCTCGCC CCC 678
(2) Sequence 820 data:
(i) sequence characteristics:
(A) length: 192 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 820: met Val Asp Ala Phe Phe Gln Ile Ala Val Leu Leu Phe Ser Leu Phe 151015 Leu Gly Ala Arg Leu Gly Gly Leu Gly Val Gly Tyr Ala Gly Gly Leu
20 25 30Gly Val Leu Ile Leu Cys Leu Phe Leu Gly Leu Asn Pro Gly Lys Ile
35 40 45Pro Phe Asp Val Ile Leu Ile Ile Met Ala Val Ile Ser Ala Ile Ser
50 55 60Ala Met Gln Lys Ala Gly Gly Leu Asp Tyr Leu Val Lys Ile Ala Glu65 70 75 80Lys Ile Leu Arg Lys His Pro Lys Gln Ile Asn Tyr Leu Ala Pro Ser
85 90 95Val Ala Tyr Cys Leu Thr Ile Leu Ala Gly Thr Gly His Thr Val Phe
100 105 110Ser Leu Ile Pro Val lle Val Glu Val Ser Gln Ser Gln Asn Ile Lys
115 120 125Pro Lys Ala Pro Leu Ser Leu Ala Val Val Ser Ser Gln Val Ala Ile
130 135 140Thr Ala Ser Pro Val Ser Ala Ala Xaa Gly Val Tyr Glu Arg His Phe145 150 155 160Arg Ala Phe Arg Ser Lys Leu Leu Asp Pro Phe Asn Gly Leu Asp Pro
165 170 175Tyr Asp Phe Phe Ser Met His Ala His Gly Ile Tyr Tyr Gly Phe Tyr
180 185 190
(2) Sequence 821 data:
(i) sequence characteristics:
(A) length: 1038bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 22...1005
(D) Other information:
(xi) Description of the sequence: sequence 821: AAAACTTTGA TATGAGAATA A ATG GAC TTT AAA AAT AAA AAA TGG CTT TTT 51
Met Asp Phe Lys Asn Lys Lys Trp Leu Phe
1 5 10CTA GCC CCT TTA GCA GGC TAT ACG GAT TTG CCT TTC AGG AGC GTG GTG 99Leu Ala Pro Leu Ala Gly Tyr Thr Asp Leu Pro Phe Arg Ser Val Val
15 20 25AAA AAA TTT GGC GTG GAT GTT ACC ACG AGC GAA ATG GTG AGC TCG CAT 147Lys Lys Phe Gly Val Asp Val Thr Thr Ser Glu Met Val Ser Ser His
30 35 40TCG TTG GTG TAT GCG TTT GAT AAA ACT TCT AAA ATG TTG GAA AAA TCC 195Ser Leu Val Tyr Ala Phe Asp Lys Thr Ser Lys Met Leu Glu Lys Ser
45 50 55CCT TTA GAA GAT CAT TTC ATG GCG CAA ATT TCA GGC TCT AAA GAA AGC 243Pro Leu Glu Asp His Phe Met Ala Gln Ile Ser Gly Ser Lys Glu Ser
60 65 70GTA GTC AAA GAA GCG GTG GAG AAA ATC AAC GCT TTA GAG CAT GTG AAT 291Val Val Lys Glu Ala Val Glu Lys Ile Asn Ala Leu Glu His Val Asn75 80 85 90GGG ATT GAT TTT AAT TGC GGT TGT CCC GCT CCT AAA GTG GCT AAT CAT 339Gly Ile Asp Phe Asn Cys Gly Cys Pro Ala Pro Lys Val Ala Asn His
95 100 105GGT AAT GGT AGT GGG TTA TTG AAG GAT TTA AAC CAC TTA GTGAAG CTT 387Gly Asn Gly Ser Gly Leu Leu Lys Asp Leu Asn His Leu Val Lys Leu
110 115 120TTA AAA ACC ATC AGA GAA AAC ACT AGT AAA AAA ATC ACA AGC GTG AAA 435Leu Lys Thr Ile Arg Glu Asn Thr Ser Lys Lys Ile Thr Ser Val Lys
125 130 135GTG CGT TTA GGC TTT GAA AAG AAA ATC CCT AAA GAA ATC GCT CAT GCC 483Val Arg Leu Gly Phe Glu Lys Lys Ile Pro Lys Glu Ile Ala His Ala
140 145 150CTA AAT GAC GCA CCG GTG GAT TAT GTG GTG GTG CAT GGG AGG ACA CGA 531Leu Asn Asp Ala Pro Val Asp Tyr Val Val Val His Gly Arg Thr Arg155 160 165 170AGC GAT AAA TAC CAA AAA GAC AAA ATA GAT TAC GAA AGC ATC GCT TTA 579Ser Asp Lys Tyr Gln Lys Asp Lys Ile Asp Tyr Glu Ser Ile Ala Leu
175 180 185ATG AAA AAG ATT TTA AAA AAG CCG GTG ATA GCC AAT GGC GAA ATT GAC 627Met Lys Lys Ile Leu Lys Lys Pro Val Ile Ala Asn Gly Glu Ile Asp
190 195 200AGC GTG AAA AAG GCT TTT GAA GTT TTA CAA ATC ACT CAA GCG GAT GGG 675Ser Val Lys Lys Ala Phe Glu Val Leu Gln Ile Thr Gln Ala Asp Gly
205 210 215CTA ATG ATA GGG CGA GCG GCC TTA AGA GCC CCA TGG ATA TTT TGG CAA 723Leu Met Ile Gly Arg Ala Ala Leu Arg Ala Pro Trp Ile Phe Trp Gln
220 225 230ATC AGA AAC AAC ACC ACA AAA TTA CCC GCA GTC GTG AAA AAA GAC CTG 771Ile Arg Asn Asn Thr Thr Lys Leu Pro Ala Val Val Lys Lys Asp Leu235 240 245 250GTT TTA GAA CAT TTT GAT AAA ATG GTG GAG TTT TAT GGG GAT ATG GGG 819Val Leu Glu His Phe Asp Lys Met Val Glu Phe Tyr Gly Asp Met Gly
255 260 265GTA ATC ATG TTT AGG AAA AAT TTG CAT GCT TAC GCT AAG GGC GAA ATG 867Val Ile Met Phe Arg Lys Asn Leu His Ala Tyr Ala Lys Gly Glu Met
270 275 280CAA GCG AGC GCG TTT CGT AAC TGC GTC AAT ACC CTT ACA GAA ATA AAG 915Gln Ala Ser Ala Phe Arg Asn Cys Val Asn Thr Leu Thr Glu Ile Lys
285 290 295AGC ATG CGA GAG AGC ATA GAG GAA TTT TTT AAT CAA GAA ATG TTG CAA 963Ser Met Arg Glu Ser Ile Glu Glu Phe Phe Asn Gln Glu Met Leu Gln
300 305 310AGT GAA GTG CCG TTA TGG GTA GAA TTG AAT CAA AAA AGC GTT TGAAAGCGC 1014Ser Glu Val Pro Leu Trp Val Glu Leu Asn Gln Lys Ser Val315 320 325TTGTTTTTTT AGCCAGCTTG GGGG 1038
(2) Sequence 822 data:
(i) sequence characteristics:
(A) length: 328 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 822: met Asp Phe Lys Asn Lys Lys Trp Leu Phe Leu Ala Pro Leu Ala Gly 151015 Tyr Thr Asp Leu Pro Phe Arg Ser Val Val Lys Lys Phe Gly Val Asp
20 25 30Val Thr Thr Ser Glu Met Val Ser Ser His Ser Leu Val Tyr Ala Phe
35 40 45Asp Lys Thr Ser Lys Met Leu Glu Lys Ser Pro Leu Glu Asp His Phe
50 5560Met Ala Gln Ile Ser Gly Ser Lys Glu Ser Val Val Lys Glu Ala Val65 70 75 80Glu Lys Ile Asn Ala Leu Glu His Val Asn Gly Ile Asp Phe Asn Cys
85 90 95Gly Cys Pro Ala Pro Lys Val Ala Asn His Gly Asn Gly Ser Gly Leu
100 105 110Leu Lys Asp Leu Asn His Leu Val Lys Leu Leu Lys Thr Ile Arg Glu
115 120 125Asn Thr Ser Lys Lys Ile Thr Ser Val Lys Val Arg Leu Gly Phe Glu
130 135 140Lys Lys Ile Pro Lys Glu Ile Ala His Ala Leu Asn Asp Ala Pro Val145 150 155 160Asp Tyr Val Val Val His Gly Arg Thr Arg Ser Asp Lys Tyr Gln Lys
165 170 175Asp Lys Ile Asp Tyr Glu Ser Ile Ala Leu Met Lys Lys Ile Leu Lys
180 185 190Lys Pro Val Ile Ala Asn Gly Glu Ile Asp Ser Val Lys Lys Ala Phe
195 200 205Glu Val Leu Gln Ile Thr Gln Ala Asp Gly Leu Met Ile Gly Arg Ala
210 215 220Ala Leu Arg Ala Pro Trp Ile Phe Trp Gln Ile Arg Asn Asn Thr Thr225 230 235 240Lys Leu Pro Ala Val Val Lys Lys Asp Leu Val Leu Glu His Phe Asp
245 250 255Lys Met Val Glu Phe Tyr Gly Asp Met Gly Val Ile Met Phe Arg Lys
260 265 270Asn Leu His Ala Tyr Ala Lys Gly Glu Met Gln Ala Ser Ala Phe Arg
275 280 285AsnCys Val Asn Thr Leu Thr Glu Ile Lys Ser Met Arg Glu Ser Ile
290 295 300Glu Glu Phe Phe Asn Gln Glu Met Leu Gln Ser Glu Val Pro Leu Trp305 310 315 320Val Glu Leu Asn Gln Lys Ser Val
325
(2) Sequence 823 data:
(i) sequence characteristics:
(A) length: 1170bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 24...1130
(D) Other information:
(xi) Description of the sequence: sequence 823: TCAAAAATTA AAGGTTAATT TTA ATG TTG CTT TTC ACT CCA GGC CCT GTA GCC 53
Met Leu Leu Phe Thr Pro Gly Pro Val Ala
1 5 10ATT AAT GAA GAG ATG CGC ACA AGC TTT TCT CAG CCA ATG CCC CAC CAC 101Ile Asn Glu Glu Met Arg Thr Ser Phe Ser Gln Pro Met Pro His His
15 20 25CGC ACT AAA GAT TTT GAA AAG ATT TTC CAA AGC GTG CGA GAA AAT TTG 149Arg Thr Lys Asp Phe Glu Lys Ile Phe Gln Ser Val Arg Glu Asn Leu
30 35 40AAA AAA ATG ACC GGT TTA GAA GAG GTT TTG CTT CTA AGC AGC AGC GGG 197Lys Lys Met Thr Gly Leu Glu Glu Val Leu Leu Leu Ser Ser Ser Gly
45 50 55ACA GGG GCT ATG GAA GCG AGC GTG ATT TCC TTG TGT CAA AAA GAG TTG 245Thr Gly Ala Met Glu Ala Ser Val Ile Ser Leu Cys Gln Lys Glu Leu
60 65 70CTT TTT GTT AAT GCG GGC AAG TTT GGC GAA AGG TTT GGC AAG ATC GCT 293Leu Phe Val Asn Ala Gly Lys Phe Gly Glu Arg Phe Gly Lys Ile Ala75 80 85 90AAA GCC CAT TCT ATC AAA GCC CAT GAA TTA GTC TAT GAA TGG GAC ACA 341Lys Ala His Ser Ile Lys Ala His Glu Leu Val Tyr Glu Trp Asp Thr
95 100 105CCA GCT CAA GTA GAT GAA ATA TTA AGC GTT CTT AAA GCC AAC CCT AAC 389Pro Ala Gln Val Asp Glu Ile Leu Ser Val Leu Lys Ala Asn Pro Asn
110 115 120ATT GAT GCG TTT TGC ATT CAA GCA TGC GAG TCT AGT GGG GGG TTA CGA 437Ile Asp Ala Phe Cys Ile Gln Ala Cys Glu Ser Ser Gly Gly Leu Arg
125 130 135CAC CCT GTG GAA AAA ATC GCT CAA GCG ATC AAA GAA ACT AAC CCG AAT 485His Pro Val Glu Lys Ile Ala Gln Ala Ile Lys Glu Thr Asn Pro Asn
140 145 150GTT TTT GTA ATT GTA GAT GCT ATC ACC GCT TTA GGG GTT GAG CCT TTA 533Val Phe Val Ile Val Asp Ala Ile Thr Ala Leu Gly Val Glu Pro Leu155 160 165 170GAA ATA ACG CAT GTT GAT GCG CTC ATT GGA GGG AGT CAA AAA GCG TTC 581Glu Ile Thr His Val Asp Ala Leu Ile Gly Gly Ser Gln Lys Ala Phe
175 180 185ATG CTG CCT CCT GCG ATG AGC CTA GTC GCA TTG AGC CAG AAT GCA ATT 629Met Leu Pro Pro Ala Met Ser Leu Val Ala Leu Ser Gln Asn Ala Ile
190 195 200GAG CGT ATA GAAGAA CGC AAT GTG GGG TTT TAT TTC AAT TTA AAG AGC 677Glu Arg Ile Glu Glu Arg Asn Val Gly Phe Tyr Phe Asn Leu Lys Ser
205 210 215GAA TTG AAA AAC CAA AGG AAT AAC ACC ACA AGC TAC ACC GCT CCT ATT 725Glu Leu Lys Asn Gln Arg Asn Asn Thr Thr Ser Tyr Thr Ala Pro Ile
220 225 230TTA CAC ACT TTA GGG TTG CAA CGC TAT TTT GAA TTG GTG CAA AAT TTA 773Leu His Thr Leu Gly Leu Gln Arg Tyr Phe Glu Leu Val Gln Asn Leu235 240 245 250GGG GGC TTT GAA GCG CTC TAT AGA GAG ACT AAA AAA GCC GCT TTG GCC 821Gly Gly Phe Glu Ala Leu Tyr Arg Glu Thr Lys Lys Ala Ala Leu Ala
255 260 265ACT CAA AAA GCC GTT TTA GCT TTA GGT TTA AAG ATT TTC CCT AAA AGC 869Thr Gln Lys Ala Val Leu Ala Leu Gly Leu Lys Ile Phe Pro Lys Ser
270 275 280CCA AGC TTG AGC ATG ACA ACG ATT GTT AAT GAG CAT GCC AAA GAA TTG 917Pro Ser Leu Ser Met Thr Thr Ile Val Asn Glu His Ala Lys Glu Leu
285 290 295AGA AAC CTT TTA AAA GAA AAA TAC CAG GTG CAA TTT GCG GGC GGT CAA 965Arg Asn Leu Leu Lys Glu Lys Tyr Gln Val Gln Phe Ala Gly Gly Gln
300 305 310GAG CCT TAT AAA GAT GCG CTC ATT CGT ATC AAC CAC ATG GGG ATC ATT 1013Glu Pro Tyr Lys Asp Ala Leu Ile Arg Ile Asn His Met Gly Ile Ile315 320 325 330CCT GTT TAT AAA AGC GCT TAC GCT TTA AAC GCC CTA GAG TTA GCC CTA 1061Pro Val Tyr Lys Ser Ala Tyr Ala Leu Asn Ala Leu Glu Leu Ala Leu
335 340 345AAC GAC TTG GAT TTA AGG GAA TTT GAT GGC GTG GCG AAC GCA ACT TTT 1109Asn Asp Leu Asp Leu Arg GluPhe Asp Gly Val Ala Asn Ala Thr Phe
350 355 360TTA AAG CAA TAT TAT GGA ATT TAAGGATCAC AATGCATTAT TCTTATGAAA CCTT 1164Leu Lys Gln Tyr Tyr Gly Ile
365TTTAAA 1170
(2) Sequence 824 data:
(i) sequence characteristics:
(A) length: 369 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 824: met Leu Leu Phe Thr Pro Gly Pro Val Ala Ile Asn Glu Glu Met Arg 151015 Thr Ser Phe Ser Gln Pro Met Pro His His Arg Thr Lys Asp Phe Glu
20 25 30Lys Ile Phe Gln Ser Val Arg Glu Asn Leu Lys Lys Met Thr Gly Leu
35 40 45Glu Glu Val Leu Leu Leu Ser Ser Ser Gly Thr Gly Ala Met Glu Ala
50 55 60Ser Val Ile Ser Leu Cys Gln Lys Glu Leu Leu Phe Val Asn Ala Gly65 70 75 80Lys Phe Gly Glu Arg Phe Gly Lys Ile Ala Lys Ala His Ser Ile Lys
85 90 95Ala His Glu Leu Val Tyr Glu Trp Asp Thr Pro Ala Gln Val Asp Glu
100 105 110Ile Leu Ser Val Leu Lys Ala Asn Pro Asn Ile Asp Ala Phe Cys Ile
115 120 125Gln Ala Cys Glu Ser Ser Gly Gly Leu Arg HisPro Val Glu Lys Ile
130 135 140Ala Gln Ala Ile Lys Glu Thr Asn Pro Asn Val Phe Val Ile Val Asp145 150 155 160Ala Ile Thr Ala Leu Gly Val Glu Pro Leu Glu Ile Thr His Val Asp
165 170 175Ala Leu Ile Gly Gly Ser Gln Lys Ala Phe Met Leu Pro Pro Ala Met
180 185 190Ser Leu Val Ala Leu Ser Gln Asn Ala Ile Glu Arg Ile Glu Glu Arg
195 200 205Ash Val Gly Phe Tyr Phe Asn Leu Lys Ser Glu Leu Lys Asn Gln Arg
210 215 220Asn Asn Thr Thr Ser Tyr Thr Ala Pro Ile Leu His Thr Leu Gly Leu225 230 235 240Gln Arg Tyr Phe Glu Leu Val Gln Asn Leu Gly Gly Phe Glu Ala Leu
245 250 255Tyr Arg Glu Thr Lys Lys Ala Ala Leu Ala Thr Gln Lys Ala Val Leu
260 265 270Ala Leu Gly Leu Lys Ile Phe Pro Lys Ser Pro Ser Leu Ser Met Thr
275 280 285Thr Ile Val Asn Glu His Ala Lys Glu Leu Arg Asn Leu Leu Lys Glu
290 295 300Lys Tyr Gln Val Gln Phe Ala Gly Gly Gln Glu Pro Tyr Lys Asp Ala305 310 315 320Leu Ile Arg Ile Asn His Met Gly Ile Ile Pro Val Tyr Lys Ser Ala
325 330 335Tyr Ala Leu Asn Ala Leu Glu Leu Ala Leu Asn Asp Leu Asp Leu Arg
340 345 350Glu Phe Asp Gly Val Ala Asn Ala Thr Phe Leu Lys Gln Tyr Tyr Gly
355 360 365Ile
(2) Sequence 825 data:
(i) sequence characteristics:
(A) length: 285bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 46...270
(D) Other information:
(xi) Description of the sequence: sequence 825: AAGAGGCATG ACAGCTCTTA CATTGTGATA GACGAATTAG TGGGC ATG TGG TTG GCG 57
Met Trp Leu Ala
1ATG GCG ATT AGC GGG TTA TCG TTA GCG GGT GTG ATC TTG AGT TTT ATC 105Met Ala Ile Ser Gly Leu Ser Leu Ala Gly Val Ile Leu Ser Phe Ile 5 10 15 20TTT TTT AGG ATC TAT GAT ATT ACT AAA CCC TCA CTC ATT GGC AAG ATA 153Phe Phe Arg Ile Tyr Asp Ile Thr Lys Pro Ser Leu Ile Gly Lys Ile
25 30 35GAT AAA GAA GTT AAA GGG GGC TTA GGG GTT GTG GCT GAT GAC GCT TTA 201Asp Lys Glu Val Lys Gly Gly Leu Gly Val Val Ala Asp Asp Ala Leu
40 45 50GCG GGT GTT TTA GCC GGA TTG AGC GCG TTA TTA GTC ATC CAT ATT TTA 249Ala Gly Val Leu Ala Gly Leu Ser Ala Leu Leu Val Ile His Ile Leu
55 60 65GGA TTT TTT AAC ATT AAA CTT TAATTTTAAG AAAAT 285Gly Phe Phe Asn Ile Lys Leu
70 75
(2) Sequence 826 data:
(i) sequence characteristics:
(A) length: 75 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 826: met Trp Leu Ala Met Ala Ile Ser Gly Leu Ser Leu Ala Gly Val Ile 151015 Leu Ser Phe Ile Phe Phe Arg Ile Tyr Asp Ile Thr Lys Pro Ser Leu
20 25 30Ile Gly Lys Ile Asp Lys Glu Val Lys Gly Gly Leu Gly Val Val Ala
35 40 45Asp Asp Ala Leu Ala Gly Val Leu Ala Gly Leu Ser Ala Leu Leu Val
50 55 60Ile His Ile Leu Gly Phe Phe Asn Ile Lys Leu65 70 75
(2) Sequence 827 data:
(i) sequence characteristics:
(A) length: 1021bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...957
(D) Other information:
(xi) Description of the sequence: sequence 827: AAAGATAGGA TTAAATATTT TATTTTTTTA GATGAAAACC ATCATTTTTA TTTGATTGAA 60GAATCCAAC ATG CAT TCA AAA TAC TTC GCT CAA ATC AAA GAA AAA AAA TTA 111
Met His Ser Lys Tyr Phe Ala Gln Ile Lys Glu Lys Lys Leu
1 5 10CCT CCC CTA ATC CTC ACA CAC AAT GGC TTG CTT AAA AAC TCA TTT TTA 159Pro Pro Leu Ile Leu Thr His Asn Gly Leu Leu Lys Asn Ser Phe Leu15 20 25 30GGT GCT AAG ATT ATA GAA TTG CCT TTA GTG ATC AAT CTC GTG CAT GGG 207Gly Ala Lys Ile Ile Glu Leu Pro Leu Val Ile Asn Leu Val His Gly
35 40 45GGC GAT GGC GAA GAT GGG AAA TTA GCG AGC TTG TTA GAA TTT TAT CGT 255Gly Asp Gly Glu Asp Gly Lys Leu Ala Ser Leu Leu Glu Phe Tyr Arg
50 55 60ATC GCT TTT ATA GGC CCT AGG ATT GAA GCG AGC GTG CTG AGT TAT AAC 303Ile Ala Phe Ile Gly Pro Arg Ile Glu Ala Ser Val Leu Ser Tyr Asn
65 70 75AAA TAT TTA ACC AAG CTT TAC GCC AAA GAC TTA GGG GTA AAG ACT TTA 351Lys Tyr Leu Thr Lys Leu Tyr Ala Lys Asp Leu Gly Val Lys Thr Leu
80 85 90GAT CAT GTT CTT TTG AAT GAA AAA AAC CGC GCT AAC GCC TTG GAT TTG 399Asp His Val Leu Leu Asn Glu Lys Asn Arg Ala Asn Ala Leu Asp Leu95 100 105 110ATG AAC TTT AAT TTC CCT TTC ATA ATC AAG CCT AAT AAC GCC GGA AGC 447Met Asn Phe Asn Phe Pro Phe Ile Ile Lys Pro Asn Asn Ala Gly Ser
115 120 125TCT TTA GGG GTG AAT GTT GTG AAA GAA GAA AAA GAA TTG GTT TAC GCT 495Ser Leu Gly Val Asn Val Val Lys Glu Glu Lys Glu Leu Val Tyr Ala
130 135 140TTA GAC GGT GCG TTT GAA TAT TCT AAA GAG GTC TTG ATA GAG CCT TTC 543Leu Asp Gly Ala Phe Glu Tyr Ser Lys Glu Val Leu Ile Glu Pro Phe
145 150 155ATT CAG GGA GTG AAA GAA TAC AAT TTG GCC GGT TGC AAG ATC AAA AAG 591Ile Gln Gly Val Lys Glu Tyr Asn Leu Ala Gly Cys Lys Ile Lys Lys
160 165 170GAT TTT TGT TTT TCC TAT GTG GAA GAG CCT AAC AAA CAG GAA TTT TTA 639Asp Phe Cys Phe Ser Tyr Val Glu Glu Pro Asn Lys Gln Glu Phe Leu175 180 185 190GAT TTC AAA CAA AAA TAT TTG GAT TTT TCA CGC AAT AAA GCC CCT AAA 687Asp Phe Lys Gln Lys Tyr Leu Asp Phe Ser Arg Asn Lys Ala Pro Lys
195 200 205GCG AAT CTT TCT AAC GCC CTA GAA GAG CAA TTA AAA GAA AAT TTT AAA 735Ala Asn Leu Ser Asn Ala Leu Glu Glu Gln Leu Lys Glu Asn Phe Lys
210 215 220AAA CTC TAT AAC GAT TTG TTT GAT GGC GCG ATC ATT CGT TGC GAT TTT 783Lys Leu Tyr Asn Asp Leu Phe Asp Gly Ala Ile Ile Arg Cys Asp Phe
225 230 235TTT GTC ATA AAA AAT GAA GTG TAT CTT AAT GAG ATC AAC CCC ATT CCT 831Phe Val Ile Lys Asn Glu Val Tyr Leu Asn Glu Ile Asn Pro Ile Pro
240 245 250GGC AGT TTG GCC AAT TAT TTG TTT GAT GAT TTT AAA ACA ACG CTA GAA 879Gly Ser Leu Ala Asn Tyr Leu Phe Asp Asp Phe Lys Thr Thr Leu Glu255 260 265 270AAT TTA GCG CAA TCA TTA CCC AAA ACC CCT AAG ATC CAA ATC AAA AAC 927Asn Leu Ala Gln Ser Leu Pro Lys Thr Pro Lys Ile Gln Ile Lys Asn
275 280 285TCT TAT TTG TTG CAA ATC CAA AAG AAT AAG TAATGGCCAA ACGCAGTATC GCT 980Ser Tyr Leu Leu Gln Ile Gln Lys Asn Lys
290 295TATTTGGATA GCGTTTTTGA CATTTCCTAC ACTTTTATAG A 1021
(2) Sequence 828 data:
(i) sequence characteristics:
(A) length: 296 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 828: met His Ser Lys Tyr Phe Ala Gln Ile Lys Glu Lys Lys Leu Pro Pro 151015 Leu Ile Leu Thr His Asn Gly Leu Leu Lys Asn Ser Phe Leu Gly Ala
20 25 30Lys Ile Ile Glu Leu Pro Leu Val Ile Asn Leu Val His Gly Gly Asp
35 40 45Gly Glu Asp Gly Lys Leu Ala Ser Leu Leu Glu Phe Tyr Arg Ile Ala
50 55 60Phe Ile Gly Pro Arg Ile Glu Ala Ser Val Leu Ser Tyr Asn Lys Tyr65 70 75 80Leu Thr Lys Leu Tyr Ala Lys Asp Leu Gly Val Lys Thr Leu Asp His
85 90 95Val Leu Leu Asn Glu Lys Asn Arg Ala Asn Ala Leu Asp Leu Met Asn
100 105 110Phe Asn Phe Pro Phe Ile Ile Lys Pro Asn Asn Ala Gly Ser Ser Leu
115 120 125Gly Val Asn Val Val Lys Glu Glu Lys Glu Leu Val Tyr Ala Leu Asp
130 135140Gly Ala Phe Glu Tyr Ser Lys Glu Val Leu Ile Glu Pro Phe Ile Gln145 150 155 160Gly Val Lys Glu Tyr Asn Leu Ala Gly Cys Lys Ile Lys Lys Asp Phe
165 170 175Cys Phe Ser Tyr Val Glu Glu Pro Asn Lys Gln Glu Phe Leu Asp Phe
180 185 190Lys Gln Lys Tyr Leu Asp Phe Ser Arg Asn Lys Ala Pro Lys Ala Asn
195 200 205Leu Ser Asn Ala Leu Glu Glu Gln Leu Lys Glu Asn Phe Lys Lys Leu
210 215 220Tyr Asn Asp Leu Phe Asp Gly Ala Ile Ile Arg Cys Asp Phe Phe Val225 230 235 240Ile Lys Asn Glu Val Tyr Leu Asn Glu Ile Asn Pro Ile Pro Gly Ser
245 250 255Leu Ala Asn Tyr Leu Phe Asp Asp Phe Lys Thr Thr Leu Glu Asn Leu
260 265 270Ala Gln Ser Leu Pro Lys Thr Pro Lys Ile Gln Ile Lys Asn Ser Tyr
275 280 285Leu Leu Gln Ile Gln Lys Asn Lys
290 295
(2) Sequence 829 data:
(i) sequence characteristics:
(A) length: 686bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 47...628
(D) Other information:
(xi) Description of the sequence: sequence 829: CAAAGCCTAT GCGAGAGTCA ATTCCGTTGC ATTTTCATTT AGAGGC ATG GAA GTC 55
Met Glu Val
1CCC ATT GAA GGT TTA GAA GAA TTG GTA GAT GAA ACG AAA AAA TGC TTG 103Pro Ile Glu Gly Leu Glu Glu Leu Val Asp Glu Thr Lys Lys Cys Leu
5 10 15ATA GAA GCT AAG AAA AAC AAA CAA AAC CAT TTC TTG CTG ATT CAA AAA 151Ile Glu Ala Lys Lys Asn Lys Gln Asn His Phe Leu Leu Ile Gln Lys20 25 30 35GCT AAC ATC CAA GCA AGA AAA CAA GCC ATG ATA GAT GAA AGT AAA ACC 199Ala Asn Ile Gln Ala Arg Lys Gln Ala Met Ile Asp Glu Ser Lys Thr
40 45 50ATT ATC CAT GTT GCA TCA GGA GCG GCT GGA GCG GCC GGG CTT ATC CCC 247Ile Ile His Val Ala Ser Gly Ala Ala Gly Ala Ala Gly Leu Ile Pro
55 60 65ATA CCC TTT AGC GAT GCA CTC GCT ATC GCG CCC ATT CAA GCA GGA ATG 295Ile Pro Phe Ser Asp Ala Leu Ala Ile Ala Pro Ile Gln Ala Gly Met
70 75 80ATC TAC AAA ATG AAT GAC GCT TTT GGA ATG GAT TTG GAT AAA TCT GTA 343Ile Tyr Lys Met Asn Asp Ala Phe Gly Met Asp Leu Asp Lys Ser Val
85 90 95GCC GCA TCA TTA ATC ACC GGA TTG TTA GGC GTA ACC GCT GTC GCG CAA 391Ala Ala Ser Leu Ile Thr Gly Leu Leu Gly Val Thr Ala Val Ala Gln100 105 110 115GTG GGG AGA ACG CTT GTT AAT GGT TTC CTT AAA TTC ATT CCT GTT GTG 439Val Gly Arg Thr Leu Val Asn Gly Phe Leu Lys Phe Ile Pro Val Val
120 125 130GGG AGT GTT GCA GGG GGC ACA ACC GCT GTA ATT ATC ACA GAA GGC ATT 487Gly Ser Val Ala Gly Gly Thr Thr Ala Val Ile Ile Thr Glu Gly Ile
135 140 145GGG TTT GCG TAT TTG AAA GTG CTA GAA AAG TGC TTT AAT GAT GAG ACG 535Gly Phe Ala Tyr Leu Lys Val Leu Glu Lys Cys Phe Asn Asp Glu Thr
150 155 160GGC GAA GTC AAT TTG CCT GAT GAA GTT GGC ATG ATA ACT TCT CTC TTT 583Gly Glu Val Asn Leu Pro Asp Glu Val Gly Met Ile Thr Ser Leu Phe
165 170 175AAG GAG AAT TAT CTC AAC TTG GAT ACA ATC AAG AAA TTA ACA CAA TAAGA 633Lys Glu Asn Tyr Leu Asn Leu Asp Thr Ile Lys Lys Leu Thr Gln180 185 190TTAGGGGTTA TGAAAAACGC ATGGCATTAG ACAAAAGGAT TTGGATGCAT TTT 686
(2) Sequence 830 data:
(i) sequence characteristics:
(A) length: 194 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 830: met Glu Val Pro Ile Glu Gly Leu Glu Glu Leu Val Asp Glu Thr Lys 151015 Lys Cys Leu Ile Glu Ala Lys Lys Asn Lys Gln Asn His Phe Leu Leu
20 25 30Ile Gln Lys Ala Asn Ile Gln Ala Arg Lys Gln Ala Met Ile Asp Glu
35 40 45Ser Lys Thr Ile Ile His Val Ala Ser Gly Ala Ala Gly Ala Ala Gly
50 55 60Leu Ile Pro Ile Pro Phe Ser Asp Ala Leu Ala Ile Ala Pro Ile Gln65 70 75 80Ala Gly Met Ile Tyr Lys Met Asn Asp Ala Phe Gly Met Asp Leu Asp
85 90 95Lys Ser Val Ala Ala Ser Leu Ile Thr Gly Leu Leu Gly Val Thr Ala
100 105 110Val Ala Gln Val Gly Arg Thr Leu Val Asn Gly Phe Leu Lys Phe Ile
115 120 125Pro Val Val Gly Ser Val Ala Gly Gly Thr Thr Ala Val Ile Ile Thr
130 135 140Glu Gly Ile Gly Phe Ala Tyr Leu Lys Val Leu Glu Lys Cys Phe Asn145 150 155 160Asp Glu Thr Gly Glu Val Asn Leu Pro Asp Glu Val Gly Met Ile Thr
165 170 175Ser Leu Phe Lys Glu Asn Tyr Leu Asn Leu Asp Thr Ile Lys Lys Leu
180 185 190Thr Gln
(2) Sequence 831 data:
(i) sequence characteristics:
(A) length: 900bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 6...821
(D) Other information:
(xi) Description of the sequence: sequence 831: AGAAG ATG GGG AAG TTT ATG AAT ACT CTT AAA AAG CAT TTA GCC TTT ATC 50
Met Gly Lys Phe Met Asn Thr Leu Lys Lys His Leu Ala Phe Ile
1 5 10 15ATT CCC CTA GTA GCG TTA TTG TTT AGC TTG GAG TGC GTG TTA TTT ATC 98Ile Pro Leu Val Ala Leu Leu Phe Ser Leu Glu Cys Val Leu Phe Ile
20 25 30AAT CAA GCG ATC GAA CAG AAA GAA AAA AAA TTG ATT GAA GAT TAT TCG 146Asn Gln Ala Ile Glu Gln Lys Glu Lys Lys Leu Ile Glu Asp Tyr Ser
35 40 45GTC GTG TTG GCC AGC ACG CAA AAA TTA AAC TTG GAA TTGTTG CGT CAA 194Val Val Leu Ala Ser Thr Gln Lys Leu Asn Leu Glu Leu Leu Arg Gln
50 55 60AAT TTT AGC GAA ATC ATA GCG TTA AAA GAA ATT GAT CCT AAT TAT TCT 242Asn Phe Ser Glu Ile Ile Ala Leu Lys Glu Ile Asp Pro Asn Tyr Ser
65 70 75TTA GAA CCT CTT CAA AAA ACC TTA GGC ATA GAT GGG CTT AAG GAA TTA 290Leu Glu Pro Leu Gln Lys Thr Leu Gly Ile Asp Gly Leu Lys Glu Leu80 85 90 95AGA AAA AAT TTG CCC TTT TTT TAT TCT TTA CAA CTT TCC ACA TTC CCC 338Arg Lys Asn Leu Pro Phe Phe Tyr Ser Leu Gln Leu Ser Thr Phe Pro
100 105 110ACT CAA GAG CGT TTA GAA AAC ATT AAA GAA AAA TTG CTC AAA ATC CCT 386Thr Gln Glu Arg Leu Glu Asn Ile Lys Glu Lys Leu Leu Lys Ile Pro
115 120 125GGC GTT CAA AAA GTT GAA GTC TTT GCC AAA ACT TAC ATG CAA GTG TAT 434Gly Val Gln Lys Val Glu Val Phe Ala Lys Thr Tyr Met Gln Val Tyr
130 135 140GAT CTC TTG AGT TTTATT AAA ACA GCG GTC TAT ATC TTT GCG TTA GTG 482Asp Leu Leu Ser Phe Ile Lys Thr Ala Val Tyr Ile Phe Ala Leu Val
145 150 155GTC TTT GTT TTA TCG GTT TTA TTG ATG TTT AAA CAA GTC CGC ATC TGG 530Val Phe Val Leu Ser Val Leu Leu Met Phe Lys Gln Val Arg Ile Trp160 165 170 175ATC TAT CAA TAC CAT GAG AGA TTA GAG ATC ATG GAT TTA TTA GGG GCT 578Ile Tyr Gln Tyr His Glu Arg Leu Glu Ile Met Asp Leu Leu Gly Ala
180 185 190TCG GTG TCT TTT AAA AAC GGG TTT TTG TAT AAA ATA GCT TTA ATG GAT 626Ser Val Ser Phe Lys Asn Gly Phe Leu Tyr Lys Ile Ala Leu Met Asp
195 200 205TCT GTA ATC GCT AGT TTT TTA GCC CCC ATG CTC ATG CTC TAT ACC ACT 674Ser Val Ile Ala Ser Phe Leu Ala Pro Met Leu Met Leu Tyr Thr Thr
210 215 220TCG CAA AAA GGT TTT GAA AAA ACG ATG GAT ACT TTG GGT ATT ATA GGA 722Ser Gln Lys Gly Phe Glu Lys Thr Met Asp Thr Leu Gly Ile Ile Gly
225 230 235GGC GCG TTT GTT TTA AAC CAT TTT TTA TGG GGA CTG CTT TTT AGC CTT 770Gly Ala Phe Val Leu Asn His Phe Leu Trp Gly Leu Leu Phe Ser Leu240 245 250 255GTG GTC TCA TTT GTT TCT GTT TTA CTT GTA GCT TGG AGG ACT AGG CAT 818Val Val Ser Phe Val Ser Val Leu Leu Val Ala Trp Arg Thr Arg His
260 265 270GTA TAAATTAGGG GTGTTTTTGT TAGCCACCTT ACTATCAGCT AACACGCAAA AAGTGA 877ValGCGATATTGC TAAAGATATC CAA 900
(2) Sequence 832 data:
(i) sequence characteristics:
(A) length:272 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 832: met Gly Lys Phe Met Asn Thr Leu Lys Lys His Leu Ala Phe Ile Ile 151015 Pro Leu Val Ala Leu Leu Phe Ser Leu Glu Cys Val Leu Phe Ile Asn
20 25 30Gln Ala Ile Glu Gln Lys Glu Lys Lys Leu Ile Glu Asp Tyr Ser Val
35 40 45Val Leu Ala Ser Thr Gln Lys Leu Asn Leu Glu Leu Leu Arg Gln Asn
50 55 60Phe Ser Glu Ile Ile Ala Leu Lys Glu Ile Asp Pro Asn Tyr Ser Leu65 70 75 80Glu Pro Leu Gln Lys Thr Leu Gly Ile Asp Gly Leu Lys Glu Leu Arg
85 90 95Lys Asn Leu Pro Phe Phe Tyr Ser Leu Gln Leu Ser Thr Phe Pro Thr
100 105 110Gln Glu Arg Leu Glu Asn Ile Lys Glu Lys Leu Leu Lys Ile Pro Gly
115 120 125Val Gln Lys Val Glu Val Phe Ala Lys Thr Tyr Met Gln Val Tyr Asp
130 135 140Leu Leu Ser Phe Ile Lys Thr Ala Val Tyr Ile Phe Ala Leu Val Val145 150 155 160Phe Val Leu Ser Val Leu Leu Met Phe Lys Gln Val Arg Ile Trp Ile
165 170 175Tyr Gln Tyr His Glu Arg Leu Glu Ile Met Asp Leu Leu Gly Ala Ser
180 185190Val Ser Phe Lys Asn Gly Phe Leu Tyr Lys Ile Ala Leu Met Asp Ser
195 200 205Val Ile Ala Ser Phe Leu Ala Pro Met Leu Met Leu Tyr Thr Thr Ser
210 215 220Gln Lys Gly Phe Glu Lys Thr Met Asp Thr Leu Gly Ile Ile Gly Gly225 230 235 240Ala Phe Val Leu Asn His Phe Leu Trp Gly Leu Leu Phe Ser Leu Val
245 250 255Val Ser Phe Val Ser Val Leu Leu Val Ala Trp Arg Thr Arg His Val
260 265 270
(2) Data for sequence 833:
(i) sequence characteristics:
(A) length: 701bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...672
(D) Other information:
(xi) Description of the sequence: sequence 833: AGG TTG TCT GAA CCC ATA GAT AGA TTC ACG CGC ATA AGG TGG TTG TTT 48Arg Leu Ser Glu Pro Ile Asp Arg Phe Thr Arg Ile Arg Trp Leu Phe 151015 AAA AAC GAT TTT GAA AAA ATC CGC CAA CAA AGG GTT TTA ATC TGT GGC 96Lys Asn Asp Phe Glu Lys Ile Arg Gln Gln Arg Val Leu Ile Cys Gly
20 25 30GTG GGG GGC GTT GGG GGC TTT GCG CTA GAC GCT TTG TAT CGT GTG GGG 144Val Gly Gly Val Gly Gly Phe Ala Leu Asp Ala Leu TyrArg Val Gly
35 40 45ATA GGG CAA ATC ACT ATC ATT GAT AAA GAC GTG TTT GAT GTT ACC AAT 192Ile Gly Gln Ile Thr Ile Ile Asp Lys Asp Val Phe Asp Val Thr Asn
50 55 60CAA AAC CGC CAG ATT GGC TCA GAA AGG ATA GGA GAA TCT AAA GTG TTG 240Gln Asn Arg Gln Ile Gly Ser Glu Arg Ile Gly Glu Ser Lys Val Leu65 70 75 80GTG TTG CAA GAT CTC TAT AAG GGC ATT CAA GCT TTG AAC TTG CAT ATA 288Val Leu Gln Asp Leu Tyr Lys Gly Ile Gln Ala Leu Asn Leu His Ile
85 90 95GAT GAA GCG TTT TTA AAT TCA TTT AAT TTT AGA GAT TAT GAT TAC ATT 336Asp Glu Ala Phe Leu Asn Ser Phe Asn Phe Arg Asp Tyr Asp Tyr Ile
100 105 110TTA GAT TGC ATG GAC GAT TTG CCT ATT AAA ACA AGC TTA GCG ATA AAA 384Leu Asp Cys Met Asp Asp Leu Pro Ile Lys Thr Ser Leu Ala Ile Lys
115 120 125TGC CAG AAT TTC GCT TAC GGA AAA TTT ATC AGC TCT ATG GGG AGT GCG 432Cys Gln Asn Phe Ala Tyr Gly Lys Phe Ile Ser Ser Met Gly Ser Ala
130 135 140AAA CGC TTG AAC CCT AAA CAC ATC CAA GTG GGG AGC GTG TGG GAA AGC 480Lys Arg Leu Asn Pro Lys His Ile Gln Val Gly Ser Val Trp Glu Ser145 150 155 160TAT GGC GAT AAA TTC GGG CGT AAA TTT AGG GAT TTT TTA AAA AAA CGC 528Tyr Gly Asp Lys Phe Gly Arg Lys Phe Arg Asp Phe Leu Lys Lys Arg
165 170 175CGT TTT AAA GGG GAT TTT AAA GTG GTT TTT AGC CCT GAA ATT CCG CAT 576Arg Phe Lys Gly Asp Phe Lys Val Val Phe Ser Pro Glu Ile Pro His
180 185 190TGC ATA GAG CTT GGG AGT TTT AAT GCG GTT ACG GCG AGT TTT GGT TTG 624Cys Ile Glu Leu Gly Ser Phe Asn Ala Val Thr Ala Ser Phe Gly Leu
195 200 205CAA ATA GCG AGT GAA GTC GTG CAA GAC ATT ATC AAC GAT AAA AGG AAG T 673Gln Ile Ala Ser Glu Val Val Gln Asp Ile Ile Asn Asp Lys Arg Lys
210 215 220GAGATGAAAG ATTACGAAGA CGAATTGG 701
(2) Data for sequence 834:
(i) sequence characteristics:
(A) length: 224 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 834: arg Leu Ser Glu Pro Ile Asp Arg Phe Thr Arg Ile Arg Trp Leu Phe 151015 Lys Asn Asp Phe Glu Lys Ile Arg Gln Gln Arg Val Leu Ile Cys Gly
20 25 30Val Gly Gly Val Gly Gly Phe Ala Leu Asp Ala Leu Tyr Arg Val Gly
35 40 45Ile Gly Gln Ile Thr Ile Ile Asp Lys Asp Val Phe Asp Val Thr Asn
50 55 60Gln Asn Arg Gln Tle Gly Ser Glu Arg Ile Gly Glu Ser Lys Val Leu65 70 75 80Val Leu Gln Asp Leu Tyr Lys Gly Ile Gln Ala Leu Asn Leu His Ile
85 90 95Asp Glu Ala Phe Leu Asn Ser Phe Asn Phe Arg Asp Tyr Asp Tyr Ile
100 105 110Leu Asp Cys Met Asp Asp Leu Pro Ile Lys Thr Ser Leu Ala Ile Lys
115 120 125Cys Gln Asn Phe Ala Tyr Gly Lys Phe Ile Ser Ser Met Gly Ser Ala
130 135 140Lys Arg Leu Asn Pro Lys His Ile Gln Val Gly Ser Val Trp Glu Ser145 150 155 160Tyr Gly Asp Lys Phe Gly Arg Lys Phe Arg Asp Phe Leu Lys Lys Arg
165 170 175Arg Phe Lys Gly Asp Phe Lys Val Val Phe Ser Pro Glu Ile Pro His
180 185 190Cys Ile Glu Leu Gly Ser Phe Asn Ala Val Thr Ala Ser Phe Gly Leu
195 200 205Gln Ile Ala Ser Glu Val Val Gln Asp Ile Ile Asn Asp Lys Arg Lys
210 215 220
(2) Sequence 835 data:
(i) sequence characteristics:
(A) length: 1260bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 73...1236
(D) Other information:
(xi) Description of the sequence: sequence 835: CTCTCGGTTT TTTTTGTGGG TAAGATTTCG CACCATCACA TTGTGGCTTT AGGGGTGGGC 60TTGCAATTTT TG ATG CTT TTT TAT GGC ATC AAC ACG ATT TTA TAC ACC GGC 111
Met Leu Phe Tyr Gly Ile Asn Thr Ile Leu Tyr Thr Gly
1 5 10ACT AAC GCC ATT CTT TCT AGG CTT GTG GGG GCT AGG GAT TTT ACT CAA 159Thr Asn Ala Ile Leu Ser Arg Leu Val Gly Ala Arg Asp Phe Thr Gln
15 20 25ATC AAC CAC GCT TTT TCC AGT ATT TTC ATA GGG GCT TTT ATG ATC TGT 207Ile Asn His Ala Phe Ser Ser Ile Phe Ile Gly Ala Phe Met Ile Cys30 35 40 45TTG GGC GTG CTG TTT GTT TCT TAT TTT TTG ATT GAG CCT TTT TTA AAT 255Leu Gly Val Leu Phe Val Ser Tyr Phe Leu Ile Glu Pro Phe Leu Asn
50 55 60TGG ATG CAA TTA CAA GAT CCT TCG CGC CAA TTG ACG CAA GAT TAT TTA 303Trp Met Gln Leu Gln Asp Pro Ser Arg Gln Leu Thr Gln Asp Tyr Leu
65 70 75GAA GTC TTA GTT GTA GCG CTA CCG AGT ATT TTT TTA AAA AAT ATT TTA 351Glu Val Leu Val Val Ala Leu Pro Ser Ile Phe Leu Lys Asn Ile Leu
80 85 90GTT TCA GCG CTC GCT AGT TTT TCA GAC ACC CTA ACC CCC TTT ATT GTC 399Val Ser Ala Leu Ala Ser Phe Ser Asp Thr Leu Thr Pro Phe Ile Val
95 100 105AAA ATC ATC ATG GTC ATT GCA TGC ATT TTT TTG AAT CAA GCC TTG ATT 447Lys Ile Ile Met Val Ile Ala Cys Ile Phe Leu Asn Gln Ala Leu Ile110 115 120 125TTT GGG GAT TTT GGT TTT AAA GAA ATG GGG ATT GTA GGC TCT GCT TTA 495Phe Gly Asp Phe Gly Phe Lys Glu Met Gly Ile Val Gly Ser Ala Leu
130 135 140GCG AAT GTG GTT GTC TCT TAT TTG GAA TTA CTC GCA CTT GGC GTT TGG 543Ala Asn Val Val Val Ser Tyr Leu Glu Leu Leu Ala Leu Gly Val Trp
145 150 155ATA CAA ATC AAA AAA ATC CCT TTA AAA TTC AAA ATA ACC TTT CAT TTT 591Ile Gln Ile Lys Lys Ile Pro Leu Lys Phe Lys Ile Thr Phe His Phe
160 165 170TCT TTT TTA AAA ACC ATG TTT AGA GTG GGT TGG CCA GCC GGG TTT GAG 639Ser Phe Leu Lys Thr Met Phe Arg Val Gly Trp Pro Ala Gly Phe Glu
175 180 185CGC TTA TTG AGT TTA TTT TCT TTA ATC CTC TTA TCC AAA TTT GTA GCG 687Arg Leu Leu Ser Leu Phe Ser Leu Ile Leu Leu Ser Lys Phe Val Ala190 195 200 205AGC TAT GGG GAT AAA GTG TTA GCG GGC ATG CAA ATA GGC ATT AGG GTT 735Ser Tyr Gly Asp Lys Val Leu Ala Gly Met Gln Ile Gly Ile Arg Val
210 215 220GAA ACC TTT TCG TTC ATG CCC GGA TTT GGG TTT ATG ATC GCA GCG ATG 783Glu Thr Phe Ser Phe Met Pro Gly Phe Gly Phe Met Ile Ala Ala Met
225 230 235GTT TTA ACA GGG CAA AAT TTA GGG GCA AAC AAG CCA AAG ATC GCC ACA 831Val Leu Thr Gly Gln Asn Leu Gly Ala Asn Lys Pro Lys Ile Ala Thr
240 245 250GAA TAC GCG CAT TTG ATT TTA AAA ATC TCT ATG GGT TTA ATG GGG GTT 879Glu Tyr Ala His Leu Ile Leu Lys Ile Ser Met Gly Leu Met Gly Val
255 260 265TTA GGG ATT GTT TTA GTC TTA TTC GCT AAA GAA TTT GCG AGC CTT TTT 927Leu Gly Ile Val Leu Val Leu Phe Ala Lys Glu Phe Ala Ser Leu Phe270 275 280 285TCT CAA GAT GAA GAA GTC TTG GAA GTG GCG CGA TCT TAT TTG ATC GCT 975Ser Gln Asp Glu Glu Val Leu Glu Val Ala Arg Ser Tyr Leu Ile Ala
290 295 300GTG GGC CTC TCT CAA GCC CCC TTA ATT GGG TAT TTT GTG CTA GAT GGA 1023Val Gly Leu Ser Gln Ala Pro Leu Ile Gly Tyr Phe Val Leu Asp Gly
305 310 315GTT TTT AGA GGG GCT GGC ATT TCT AAA GTC TCA CTG TAT ATT AAC ACC 1071Val Phe Arg Gly Ala Gly Ile Ser Lys Val Ser Leu Tyr Ile Asn Thr
320 325 330CTA AGC TTA TGG GGG TTA AGG ATC ATG CCC ATT TAC TTG CTT TTA ATT 1119Leu Ser Leu Trp Gly Leu Arg Ile Met Pro Ile Tyr Leu Leu Leu Ile
335 340 345CAT CAT TTT AAG GTG GAA TTT ATT TTT GTA GTG ATC GCA TCA GAA ACT 1167His His Phe Lys Val Glu Phe Ile Phe Val Val Ile Ala Ser Glu Thr350 355 360 365TTT TTG CGC TCA TTC ATC TAT TAT AAA GTT TTT TCT AAA GGC ATT TGG 1215Phe Leu Arg Ser Phe Ile Tyr Tyr Lys Val Phe Ser Lys Gly Ile Trp
370 375 380AAA AGG TGC GGG AAA AAG GCT TGATTATTGC TTGAGCGTAG CGGT 1260Lys Arg Cys Gly Lys Lys Ala
385
(2) Sequence 836 data:
(i) sequence characteristics:
(A) length: 388 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 836: met Leu Phe Tyr Gly Ile Asn Thr Ile Leu Tyr Thr Gly Thr Asn Ala 151015 Ile Leu Ser Arg Leu Val Gly Ala Arg Asp Phe Thr Gln Ile Asn His
20 25 30Ala Phe Ser Ser Ile Phe Ile Gly Ala Phe Met Ile Cys Leu Gly Val
35 40 45Leu Phe Val Ser Tyr Phe Leu Ile Glu Pro Phe Leu Asn Trp Met Gln
50 55 60Leu Gln Asp Pro Ser Arg Gln Leu Thr Gln Asp Tyr Leu Glu Val Leu65 70 75 80Val Val Ala Leu Pro Ser Ile Phe Leu Lys Asn Ile Leu Val Ser Ala
85 90 95Leu Ala Ser Phe Ser Asp Thr Leu Thr Pro Phe Ile Val Lys Ile Ile
100 105 110Met Val Ile Ala Cys Ile Phe Leu Asn Gln Ala Leu Ile Phe Gly Asp
115 120 125Phe Gly Phe Lys Glu Met Gly Ile Val Gly Ser Ala Leu Ala Asn Val
130 135 140Val Val Ser Tyr Leu Glu Leu Leu Ala Leu Gly Val Trp Ile Gln Ile145 150 155 160Lys Lys Ile Pro Leu Lys Phe Lys Ile Thr Phe His Phe Ser Phe Leu
165 170 175Lys Thr Met Phe Arg Val Gly Trp Pro Ala Gly Phe Glu Arg Leu Leu
180 185 190Ser Leu Phe Ser Leu Ile Leu Leu Ser Lys Phe Val Ala Ser Tyr Gly
195 200 205Asp Lys Val Leu Ala Gly Met Gln Ile Gly Ile Arg Val Glu Thr Phe
210 215 220Ser Phe Met Pro Gly Phe Gly Phe Met Ile Ala Ala Met Val Leu Thr225 230 235 240Gly Gln Asn Leu Gly Ala Asn Lys Pro Lys Ile Ala Thr Glu Tyr Ala
245 250 255His Leu Ile Leu Lys Ile Ser Met Gly Leu Met Gly Val Leu Gly Ile
260265 270Val Leu Val Leu Phe Ala Lys Glu Phe Ala Ser Leu Phe Ser Gln Asp
275 280 285Glu Glu Val Leu Glu Val Ala Arg Ser Tyr Leu Ile Ala Val Gly Leu
290 295 300Ser Gln Ala Pro Leu Ile Gly Tyr Phe Val Leu Asp Gly Val Phe Arg305 310 315 320Gly Ala Gly Ile Ser Lys Val Ser Leu Tyr Ile Asn Thr Leu Ser Leu
325 330 335Trp Gly Leu Arg Ile Met Pro Ile Tyr Leu Leu Leu Ile His His Phe
340 345 350Lys Val Glu Phe Ile Phe Val Val Ile Ala Ser Glu Thr Phe Leu Arg
355 360 365Ser Phe Ile Tyr Tyr Lys Val Phe Ser Lys Gly Ile Trp Lys Arg Cys
370 375 380Gly Lys Lys Ala385
(2) Sequence 837 data:
(i) sequence characteristics:
(A) length: 1327bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 22...1305
(D) Other information:
(xi) Description of the sequence: sequence 837: TAAACATCTA AAGGATAAAA C ATG CCA TTG CCA TTT ATT ATA GCA GCT GGA 51
Met Pro Leu Pro Phe Ile Ile Ala Ala Gly
1 5 10GTG GCC TTA GTG GCC GCA GNA TAC GGA GTT AAA AAA AAA GTT GAT GCA 99Val Ala Leu Val Ala Ala Xaa Tyr Gly Val Lys Lys Lys Val Asp Ala
15 20 25GAC ATT CTC AGT GAA GAG ACC AAT GAA TAT ATT AAG TAT ATC AAT GAA 147Asp Ile Leu Ser Glu Glu Thr Asn Glu Tyr Ile Lys Tyr Ile Asn Glu
30 35 40GGC AAT GAC TTG CTA GAG GAA GCA GAA GAA GTT ATT AAA GCT GTG GCT 195Gly Asn Asp Leu Leu Glu Glu Ala Glu Glu Val Ile Lys Ala Val Ala
45 50 55TCT GAT TGT GAG TTT GCT CTT GCG AGA TTT GAA GAG AAA AGG TGC TAT 243Ser Asp Cys Glu Phe Ala Leu Ala Arg Phe Glu Glu Lys Arg Cys Tyr
60 65 70ATT AGA AAT CAT GTA ATT TCA GAA TTT TTG CAC CAT TTT AAT CAA TTA 291Ile Arg Asn His Val Ile Ser Glu Phe Leu His His Phe Asn Gln Leu75 80 85 90GAA GGA TTC GAG CTT ACC AAC AAA AAA GAT AGC ATG GAA AAT ATC CAA 339Glu Gly Phe Glu Leu Thr Asn Lys Lys Asp Ser Met Glu Asn Ile Gln
95 100 105CTC GAT GTA TCA AAT ACA CTA AAA ATT ATT GAT AAA AAT CTC AAG ATG 387Leu Asp Val Ser Asn Thr Leu Lys Ile Ile Asp Lys Asn Leu Lys Met
110 115 120AGC TCT TTT GAC ACC CTT GGT GCC GTT GGA AAT GTT GTG GGA GGT TTT 435Ser Ser Phe Asp Thr Leu Gly Ala Val Gly Asn Val Val Gly Gly Phe
125 130 135TCT ATG GGA TTT GGT TTG GCT GCT GGA GGT ATA GTT GGA AGT GTA GGG 483Ser Met Gly Phe Gly Leu Ala Ala Gly Gly Ile Val Gly Ser Val Gly
140 145 150CTT TTA GCC GGA CCC ACA CTC GCT ATT TTT GGA GCT TTG AGA GCT GCT 531Leu Leu Ala Gly Pro Thr Leu Ala Ile Phe Gly Ala Leu Arg Ala Ala155 160 165 170GAA ATG GAA AAA AAA TTA GAA GAT GCT AAG GCT TAT TGC TCT CAA GTT 579Glu Met Glu Lys Lys Leu Glu Asp Ala Lys Ala Tyr Cys Ser Gln Val
175 180 185GAA GCA GCC GTC AAA AAA GCC GAT GCG ATG ATT GAT AAT CTT CAA GCC 627Glu Ala Ala Val Lys Lys Ala Asp Ala Met Ile Asp Asn Leu Gln Ala
190 195 200GTT AGG AAA ATG GCA GAT CTT TTC ACT AGG CAG ATC ACA AAA TTT GAC 675Val Arg Lys Met Ala Asp Leu Phe Thr Arg Gln Ile Thr Lys Phe Asp
205 210 215GCA CTG TTT TTC TCG CTT GCT CAA GAG GCA ATC GCC ACG ATG AAA AAG 723Ala Leu Phe Phe Ser Leu Ala Gln Glu Ala Ile Ala Thr Met Lys Lys
220 225 230CAC AAC TAC GAT TTT TCG CAT TAC AAT CAA AAA GAA CAA GAT CAG CTA 771His Asn Tyr Asp Phe Ser His Tyr Asn Gln Lys Glu Gln Asp Gln Leu235 240 245 250GCT ACT GCT TCT TCA ACC CTT AAA ACT TTG GGT GCT TTT TTG AAA GTG 819Ala Thr Ala Ser Ser Thr Leu Lys Thr Leu Gly Ala Phe Leu Lys Val
255 260 265CCT ATC ATG GAC AAA CAC CAA AAG CTC AAT GAA GCT ACA CAA AGT AAG 867Pro Ile Met Asp Lys His Gln Lys Leu Asn Glu Ala Thr Gln Ser Lys
270 275 280CTA GAG TTT ATG CAA AGG GAG ATG AGT AGC CTA GAA GCT AAG CAT TAT 915Leu Glu Phe Met Gln Arg Glu Met Ser Ser Leu Glu Ala Lys His Tyr
285 290 295GAT TCA GTT AAA ATC AAA TTT GGA TTG GTA CGC AGA TTA TTT GAA TTT 963Asp Ser Val Lys Ile Lys Phe Gly Leu Val Arg Arg Leu Phe Glu Phe
300 305 310TTT AGA TCG CTT TGG GGA AAA AAT GGA AGA ATC CAA AGA GCG AAA ACA 1011Phe Arg Ser Leu Trp Gly Lys Asn Gly Arg Ile Gln Arg Ala Lys Thr315 320 325 330ACT CCT GAT CGC TTC CCT TGC ACC TCT TGC GGG CTT TGC TGC AAG AAT 1059Thr Pro Asp Arg Phe Pro Cys Thr Ser Cys Gly Leu Cys Cys Lys Asn
335 340 345ATC GCC GGG ATT ATT GAG CTT ATT GGG TTT GAT GCT GGC AAT GGG GTG 1107Ile Ala Gly Ile Ile Glu Leu Ile Gly Phe Asp Ala Gly Asn Gly Val
350 355 360TGC AAA TTT TTG GAT TTA GAA ACC AAT CTG TGC AAG ATT TAT GAA TCG 1155Cys Lys Phe Leu Asp Leu Glu Thr Asn Leu Cys Lys Ile Tyr Glu Ser
365 370 375CGC CCG TTA ATT TGC AGG ATT GAT GAA GCG CAC AAA AAG CTT TAT CCC 1203Arg Pro Leu Ile Cys Arg Ile Asp Glu Ala His Lys Lys Leu Tyr Pro
380 385 390CAC ATC CCG CTT AAG GAG TTT TAT GCC AAA AAC GCA GAG GTT TGT AAC 1251His Ile Pro Leu Lys Glu Phe Tyr Ala Lys Asn Ala Glu Val Cys Asn395 400 405 410GCT TTG CAA GAA GCA AAC CAT ATG GAT AAG AGC TTT AGG GTT ATT CTT 1299Ala Leu Gln Glu Ala Asn His Met Asp Lys Ser Phe Arg Val Ile Leu
415 420 425AAG AAA TAATTTAGAA TTTATTGTCC CA 1327Lys Lys
(2) Sequence 838 data:
(i) sequence characteristics:
(A) length: 428 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 838: met Pro Leu Pro Phe Ile Ile Ala Ala Gly Val Ala Leu Val Ala Ala 151015 Xaa Tyr Gly Val Lys Lys Lys Val Asp Ala Asp Ile Leu Ser Glu Glu
20 25 30Thr Asn Glu Tyr Ile Lys Tyr Ile Asn Glu Gly Asn Asp Leu Leu Glu
35 40 45Glu Ala Glu Glu Val Ile Lys Ala Val Ala Ser Asp Cys Glu Phe Ala
50 55 60Leu Ala Arg Phe Glu Glu Lys Arg Cys Tyr Ile Arg Asn His Val Ile65 70 75 80Ser Glu Phe Leu His His Phe Asn Gln Leu Glu Gly Phe Glu Leu Thr
85 90 95Asn Lys Lys Asp Ser Met Glu Asn Ile Gln Leu Asp Val Ser Asn Thr
100 105 110Leu Lys Ile Ile Asp Lys Asn Leu Lys Met Ser Ser Phe Asp Thr Leu
115 120 125Gly Ala Val Gly Asn Val Val Gly Gly Phe Ser Met Gly Phe Gly Leu
130 135 140Ala Ala Gly Gly Ile Val Gly Ser Val Gly Leu Leu Ala Gly Pro Thr145 150 155 160Leu Ala Ile Phe Gly Ala Leu Arg Ala Ala Glu Met Glu Lys Lys Leu
165 170 175Glu Asp Ala Lys Ala Tyr Cys Ser Gln Val Glu Ala Ala Val Lys Lys
180 185 190Ala Asp Ala Met Ile Asp Asn Leu Gln Ala Val Arg Lys Met Ala Asp
195 200 205Leu Phe Thr Arg Gln Ile Thr Lys Phe Asp Ala Leu Phe Phe Ser Leu
210 215 220Ala Gln Glu Ala Ile Ala Thr Met Lys Lys His Asn Tyr Asp Phe Ser225 230 235 240His Tyr Asn Gln Lys Glu Gln Asp Gln Leu Ala Thr Ala Ser Ser Thr
245 250 255Leu Lys Thr Leu Gly Ala Phe Leu Lys Val Pro Ile Met Asp Lys His
260 265 270Gln Lys Leu Asn Glu Ala Thr Gln Ser Lys Leu Glu Phe Met Gln Arg
275 280 285Glu Met Ser Ser Leu Glu Ala Lys His Tyr Asp Ser Val Lys Ile Lys
290 295 300Phe Gly Leu Val Arg Arg Leu Phe Glu Phe Phe Arg Ser Leu Trp Gly305 310 315 320Lys Asn Gly Arg Ile Gln Arg Ala Lys Thr Thr Pro Asp Arg Phe Pro
325 330 335Cys Thr Ser Cys Gly Leu Cys Cys Lys Asn Ile Ala Gly Ile Ile Glu
340 345 350Leu Ile Gly Phe Asp Ala Gly Asn Gly Val Cys Lys Phe Leu Asp Leu
355 360 365Glu Thr Asn Leu Cys Lys Ile Tyr Glu Ser Arg Pro Leu Ile Cys Arg
370 375 380Ile Asp Glu Ala His Lys Lys Leu Tyr Pro His Ile Pro Leu Lys Glu385 390 395 400Phe Tyr Ala Lys Asn Ala Glu Val Cys Asn Ala Leu Gln Glu Ala Asn
405 410 415His Met Asp Lys Ser Phe Arg Val Ile Leu Lys Lys
420 425
(2) Sequence 839 data:
(i) sequence characteristics:
(A) length: 894bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 30...851
(D) Other information:
(xi) Description of the sequence: sequence 839: TATTAACACC GTTAAAGAGG GGGTAATTC ATG TTA GAA AAC ATG CAA GAT ATT 53
Met Leu Glu Asn Met Gln Asp Ile
1 5TCA TTG CAA AGC TCT CAT GAA GTA GGA GTG GAT ATT ACA GAG AGC AAA 101Ser Leu Gln Ser Ser His Glu Val Gly Val Asp Ile Thr Glu Ser Lys
10 15 20ATG CTT ACA AAA TTT GCA TCC TCG TTA TTA ATG AAT TTA TAT GAA TAT 149Met Leu Thr Lys Phe Ala Ser Ser Leu Leu Met Asn Leu Tyr Glu Tyr25 30 35 40ATT GGA AAT GGC AAG GAT CCC AAA GAA GCG TCC GAT CAT GCC ATG AGG 197Ile Gly Asn Gly Lys Asp Pro Lys Glu Ala Ser Asp His Ala Met Arg
45 50 55GAT GCA AAG GAT GTG GTG CTT AGT TGT GGT AGA GTA GCC TTT CTT AAA 245Asp Ala Lys Asp Val Val Leu Ser Cys Gly Arg Val Ala Phe Leu Lys
60 65 70GAC ATA GTT TCA AAT AGT CCA AAC GAA ACA ATC CAA AGT TTT GAT GGA 293AspIle Val Ser Asn Ser Pro Asn Glu Thr Ile Gln Ser Phe Asp Gly
75 80 85GAC TTA GAA GTT GCG ATG CAT TTA GAA AAA ATT GGC ATA GAA TGT TAT 341Asp Leu Glu Val Ala Met His Leu Glu Lys Ile Gly Ile Glu Cys Tyr
90 95 100AAG ATA TTT ATT GAC TAT GGT TCT CAA AAG ATC GAT GAT AAT GAG CTT 389Lys Ile Phe Ile Asp Tyr Gly Ser Gln Lys Ile Asp Asp Asn Glu Leu105 110 115 120TCT TGT CGT TTG TTA CAC ACT GGC ACG AAA ATT TTA GGC ACA AAA GCT 437Ser Cys Arg Leu Leu His Thr Gly Thr Lys Ile Leu Gly Thr Lys Ala
125 130 135ATG GCA GTT GTT GGT CAA ACA TTC ATC CCC ATT CCT GGA GGT GGA GCG 485Met Ala Val Val Gly Gln Thr Phe Ile Pro Ile Pro Gly Val Gly Ala
140 145 150ATA ATT GGA AAT TTT GTG GGT GCA TTA CTG AGC AAA ACT CTC TGT GAA 533Ile Ile Gly Asn Phe Val Gly Ala Leu Leu Ser Lys Thr Leu Cys Glu
155 160 165AAT TTG CGA GAT GTT TTA AAA GAG GCT AAA TTG GCG CGC CAA AGG CGT 581Asn Leu Arg Asp Val Leu Lys Glu Ala Lys Leu Ala Arg Gln Arg Arg
170 175 180ATA GAG ATT GAA AAA GAA TGC CGT GAA AGT ATT AGG CTG TTA GAG ATC 629Ile Glu Ile Glu Lys Glu Cys Arg Glu Ser Ile Arg Leu Leu Glu Ile185 190 195 200TAT CGC AAT CAA TTT AAG GAA GTG TTT GAG CGG TAT TTT CAT GGG AAT 677Tyr Arg Asn Gln Phe Lys Glu Val Phe Glu Arg Tyr Phe His Gly Asn
205 210 215GTA AAA TTC TTT AAT GAG AAT TTT AAT AAT CTT GAG AGG GCG CTT TAT 725Val Lys Phe Phe Asn Glu Asn Phe Asn Asn Leu Glu Arg Ala Leu Tyr
220 225 230GCA GGA GAT GCG GAT TTG GCC ATA GGA GTC AAT AAT GAG ATT CAA GAA 773Ala Gly Asp Ala Asp Leu Ala Ile Gly Val Asn Asn Glu Ile Gln Glu
235 240 245AGA CTA GGT CAA AAA CCC TTG TTT AAT AAT ACC CAA GAA TTT TTG GAA 821Arg Leu Gly Gln Lys Pro Leu Phe Asn Asn Thr Gln Glu Phe Leu Glu
250 255 260CTC ATG AAT AAT GGT GGA AAA ATA GAA ATT TAAAGGAGAA ATCATGGAAG AAC 874Leu Met Asn Asn Gly Gly Lys Ile Glu Ile265 270AAAAGGATAT GGGTCAAAGT 894
(2) Sequence 840 data:
(i) sequence characteristics:
(A) length: 274 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 840: met Leu Glu Asn Met Gln Asp Ile Ser Leu Gln Ser Ser His Glu Val 151015 Gly Val Asp Ile Thr Glu Ser Lys Met Leu Thr Lys Phe Ala Ser Ser
20 25 30Leu Leu Met Asn Leu Tyr Glu Tyr Ils Gly Asn Gly Lys Asp Pro Lys
35 40 45Glu Ala Ser Asp His Ala Met Arg Asp Ala Lys Asp Val Val Leu Ser
50 55 60Cys Gly Arg Val Ala Phe Leu Lys Asp Ile Val Ser Asn Ser Pro Asn65 70 75 80Glu Thr Ile Gln Ser Phe Asp Gly Asp Leu Glu Val Ala Met His Leu
8590 95Glu Lys Ile Gly Ile Glu Cys Tyr Lys Ile Phe Ile Asp Tyr Gly Ser
100 105 110Gln Lys Ile Asp Asp Asn Glu Leu Ser Cys Arg Leu Leu His Thr Gly
115 120 125Thr Lys Ile Leu Gly Thr Lys Ala Met Ala Val Val Gly Gln Thr Phe
130 135 140Ile Pro Ile Pro Gly Val Gly Ala Ile Ile Gly Asn Phe Val Gly Ala145 150 155 160Leu Leu Ser Lys Thr Leu Cys Glu Asn Leu Arg Asp Val Leu Lys Glu
165 170 175Ala Lys Leu Ala Arg Gln Arg Arg Ile Glu Ile Glu Lys Glu Cys Arg
180 185 190Glu Ser Ile Arg Leu Leu Glu Ile Tyr Arg Asn Gln Phe Lys Glu Val
195 200 205Phe Glu Arg Tyr Phe His Gly Asn Val Lys Phe Phe Asn Glu Asn Phe
210 215 220Asn Asn Leu Glu Arg Ala Leu Tyr Ala Gly Asp Ala Asp Leu Ala Ile225 230 235 240Gly Val Asn Asn Glu Ile Gln Glu Arg Leu Gly Gln Lys Pro Leu Phe
245 250 255Asn Asn Thr Gln Glu Phe Leu Glu Leu Met Asn Asn Gly Gly Lys Ile
260 265 270Glu Ile
(2) Sequence 841 data:
(i) sequence characteristics:
(A) length: 1338bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...1281
(D) Other information:
(xi) Description of the sequence: sequence 841: CTTCATTACG CTTACGCTAC AACCCTTAAG ATCACCAATG TTGTGCCTTT TGGCTCTAGC 60AGCGTTAAA ATG GTG TTC AAT CAA GAG GTT AAA AAA TTC AAA GAA GTT TCG 111
Met Val Phe Asn Gln Glu Val Lys Lys Phe Lys Glu Val Ser
1 5 10CTC AAA AAT TTC AAG AGT TAT TTG GAA TTA GAA GCC ATT TTA ACC ATT 159Leu Lys Asn Phe Lys Ser Tyr Leu Glu Leu Glu Ala Ile Leu Thr Ile15 20 25 30CCT AAA AAG CAT TAC CAA TTC TCC AAG CAA TCG TTC ATC ACG ATC GCG 207Pro Lys Lys His Tyr Gln Phe Ser Lys Gln Ser Phe Ile Thr Ile Ala
35 40 45CAA TTC AGC CCT AAG TTA GTG CGA GTG GTT ATC GGC TAT GCT CCT AAG 255Gln Phe Ser Pro Lys Leu Val Arg Val Val Ile Gly Tyr Ala Pro Lys
50 55 60ATG ACT TAT GAA GTT AAA ATC CTT AAA GAC AAG CTT TAT GTT TCT ATC 303Met Thr Tyr Glu Val Lys Ile Leu Lys Asp Lys Leu Tyr Val Ser Ile
65 70 75GTG GAG AAA AAG CCC TTA ATT AGG CAT CAA ATG GCG TTA AAA CCA CCC 351Val Glu Lys Lys Pro Leu Ile Arg His Gln Met Ala Leu Lys Pro Pro
80 85 90AAA CAC CAT GCA CTC AAA CAC ACA ACG CCA AAA CCC GCC CAT AAG CCC 399Lys His His Ala Leu Lys His Thr Thr Pro Lys Pro Ala His Lys Pro95 100 105 110ATT AAAAAA GAG GCT AAA AAG GTT AAA GAA AAA ACG CCA ACT AAA CAT 447Ile Lys Lys Glu Ala Lys Lys Val Lys Glu Lys Thr Pro Thr Lys His
115 120 125GCG CAT TCA AAA CAC ACG CAT TCC CCA TTG AAC GAA AGG AGC ACT AAA 495Ala His Ser Lys His Thr His Ser Pro Leu Asn Glu Arg Ser Thr Lys
130 135 140AAA GAA ATT CCT AAA AAA GAA ATT CCT AAA AAA GAA GCG GAA AAT GAG 543Lys Glu Ile Pro Lys Lys Glu Ile Pro Lys Lys Glu Ala Glu Asn Glu
145 150 155AGC AAG AAC CAA GTC TTT ATA GCA GAA AAA AAT GAT ACT TTC ATC AAA 591Ser Lys Asn Gln Val Phe Ile Ala Glu Lys Asn Asp Thr Phe Ile Lys
160 165 170ACC AAA CGC AAA AAA CAC AAA AAG ATC GTT TTA GAC GCT GGG CAT GGG 639Thr Lys Arg Lys Lys His Lys Lys Ile Val Leu Asp Ala Gly His Gly175 180 185 190GGG AAA GAT TGC GGG GCG ATG AGC GCG AAT TTG GTG TGT GAA AAA GAC 687Gly Lys Asp Cys Gly Ala Met Ser Ala Asn Leu Val Cys Glu Lys Asp
195 200 205ATT GTT TTA GAA GTG GTG AAG TTT TTA CAC AAA GAG CTT AAA AAA AGA 735Ile Val Leu Glu Val Val Lys Phe Leu His Lys Glu Leu Lys Lys Arg
210 215 220GAT TAT AGC GTT TTA TTG ACA AGG GAT AAG GAT ATT TAT ATT GAT TTA 783Asp Tyr Ser Val Leu Leu Thr Arg Asp Lys Asp Ile Tyr Ile Asp Leu
225 230 235GTG GCT CGC ACG GAA TTA GCC AAT AAA AAA AGC GCG GAT TTA TTC ATC 831Val Ala Arg Thr Glu Leu Ala Asn Lys Lys Ser Ala Asp Leu Phe Ile
240 245 250TCA GTG CAT GCC AAT TCC ATC CCC AAA CAT TCC ACT TCT AAC GCT CAT 879Ser Val His Ala AsnSer Ile Pro Lys His Ser Thr Ser Asn Ala His255 260 265 270GGT ATA GAG ACT TAT TTT TTA TCC ACC GCA AGG AGC GAA AGG GCT AGG 927Gly Ile Glu Thr Tyr Phe Leu Ser Thr Ala Arg Ser Glu Arg Ala Arg
275 280 285AAA GTG GCT GAG CAA GAA AAT AAA GAC GAT GTG AAT TTA ATG GAT TAT 975Lys Val Ala Glu Gln Glu Asn Lys Asp Asp Val Asn Leu Met Asp Tyr
290 295 300TTT TCT AAA AGT TTG TTT TTA AAT TCA TTG AAC ACG CAG CGA TTG ATC 1023Phe Ser Lys Ser Leu Phe Leu Asn Ser Leu Asn Thr Gln Arg Leu Ile
305 310 315GTC TCT AAC AAA TTA GCG ATT GAT GTG CAA TAG GGC ATG CTC CAA AGC 1071Val Ser Asn Lys Leu Ala Ile Asp Val Gln Tyr Gly Met Leu Gln Ser
320 325 330GTC CGC AAA AAT TAC CCT GAT GTG GTG GAT GGA GGC GTG AGA GAG GGG 1119Val Arg Lys Asn Tyr Pro Asp Val Val Asp Gly Gly Val Arg Glu Gly335 340 345 350CCT TTT TGG GTG TTG GCC GGG GCT TTA ATG CCT TCA ATC TTA ATA GAA 1167Pro Phe Trp Val Leu Ala Gly Ala Leu Met Pro Ser Ile Leu Ile Glu
355 360 365ATT GGT TAT AAT TCC CAT GCG ATA GAA TCT AAA CGC ATC CAA AGC AAA 1215Ile Gly Tyr Asn Ser His Ala Ile Glu Ser Lys Arg Ile Gln Ser Lys
370 375 380CCG TAT CAA AAG ATC TTG GCT AAG GGC ATT GCT GAT GGC ATT GAT AGT 1263Pro Tyr Gln Lys Ile Leu Ala Lys Gly Ile Ala Asp Gly Ile Asp Ser
385 390 395TTC TTC AGC AAG AAT GAT TAGGCAATGA TTAGGTTGTA GATGAATTTT TATCAAAA 1319Phe Phe Ser Lys Asn Asp
400AATATACACT CATAAAGTC1338
(2) Sequence 842 data:
(i) sequence characteristics:
(A) length: 404 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 842: met Val Phe Asn Gln Glu Val Lys Lys Phe Lys Glu Val Ser Leu Lys 151015 Asn Phe Lys Ser Tyr Leu Glu Leu Glu Ala Ile Leu Thr Ile Pro Lys
20 25 30Lys His Tyr Gln Phe Ser Lys Gln Ser Phe Ile Thr Ile Ala Gln Phe
35 40 45Ser Pro Lys Leu Val Arg Val Val Ile Gly Tyr Ala Pro Lys Met Thr
50 55 60Tyr Glu Val Lys Ile Leu Lys Asp Lys Leu Tyr Val Ser Ile Val Glu65 70 75 80Lys Lys Pro Leu Ile Arg His Gln Met Ala Leu Lys Pro Pro Lys His
85 90 95His Ala Leu Lys His Thr Thr Pro Lys Pro Ala His Lys Pro Ile Lys
100 105 110Lys Glu Ala Lys Lys Val Lys Glu Lys Thr Pro Thr Lys His Ala His
115 120 125Ser Lys His Thr His Ser Pro Leu Asn Glu Arg Ser Thr Lys Lys Glu
130 135 140Ile Pro Lys Lys Glu Ile Pro Lys Lys Glu Ala Glu Asn Glu Ser Lys145 150 155 160Asn Gln Val Phe Ile Ala Glu Lys Asn Asp Thr Phe Ile Lys Thr Lys
165 170 175Arg Lys Lys His Lys Lys Ile Val Leu Asp Ala Gly His Gly Gly Lys
180 185 190Asp Cys Gly Ala Met Ser Ala Asn Leu Val Cys Glu Lys Asp Ile Val
195 200 205Leu Glu Val Val Lys Phe Leu His Lys Glu Leu Lys Lys Arg Asp Tyr
210 215 220Ser Val Leu Leu Thr Arg Asp Lys Asp Ile Tyr Ile Asp Leu Val Ala225 230 235 240Arg Thr Glu Leu Ala Asn Lys Lys Ser Ala Asp Leu Phe Ile Ser Val
245 250 255His Ala Asn Ser Ile Pro Lys His Ser Thr Ser Asn Ala His Gly Ile
260 265 270Glu Thr Tyr Phe Leu Ser Thr Ala Arg Ser Glu Arg Ala Arg Lys Val
275 280 285Ala Glu Gln Glu Asn Lys Asp Asp Val Asn Leu Met Asp Tyr Phe Ser
290 295 300Lys Ser Leu Phe Leu Asn Ser Leu Asn Thr Gln Arg Leu Ile Mal Ser305 310 315 320Asn Lys Leu Ala Ile Asp Val Gln Tyr Gly Met Leu Gln Ser Val Arg
325 330 335Lys Asn Tyr Pro Asp Val Val Asp Gly Gly Val Arg Glu Gly Pro Phe
340 345 350Trp Val Leu Ala Gly Ala Leu Met Pro Ser Ile Leu Ile Glu Ile Gly
355 360 365Tyr Asn Ser His Ala Ile Glu Ser Lys Arg Ile Gln Ser Lys Pro Tyr
370 375 380Gln Lys Ile Leu Ala Lys Gly Ile Ala AspGly Ile Asp Ser Phe Phe385 390 395 400Ser Lys Asn Asp
(2) Data of sequence 843:
(i) sequence characteristics:
(A) length: 1161bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 37...1125
(D) Other information:
(xi) Description of the sequence: sequence 843: TGAAATTAAA TATTAACTAA TATTAAGGAA AGAGCT ATG GTA TCA ACA CTC AAA 54
Met Val Ser Thr Leu Lys
1 5CCG CTA AAA ATC GGT AAG CAC ACC ATA AAA TTC CCT ATC TTT CAA GGG 102Pro Leu Lys Ile Gly Lys His Thr Ile Lys Phe Pro Ile Phe Gln Gly
10 15 20GGA ATG GGT GTG GGG ATT AGC TGG GAT GAA CTA GCT GGA AAT GTT GCC 150Gly Met Gly Val Gly Ile Ser Trp Asp Glu Leu Ala Gly Asn Val Ala
25 30 35AAA GAA GGG GCT TTA GGA GTG ATT TCA GCC GTA GGG ACT GGT TAT TAT 198Lys Glu Gly Ala Leu Gly Val Ile Ser Ala Val Gly Thr Gly Tyr Tyr
40 45 50AAA AAC ATG CGT TTT GTA GAA AGG ATT GTG GCT AAA AAA CCC TTT GAA 246Lys Asn Met Arg Phe Val Glu Arg Ile Val Ala Lys Lys Pro Phe Glu55 60 65 70GCC TTG AAT TTTTAC TCC AAA AAA GCG TTG AAT GAG ATT TTT GCA AAC 294Ala Leu Asn Phe Tyr Ser Lys Lys Ala Leu Asn Glu Ile Phe Ala Asn
75 80 85GCT AGG AAG ATT TGC GGG AAC AAC CCT TTA GGA GCG AAT ATT TTA TAC 342Ala Arg Lys Ile Cys Gly Asn Asn Pro Leu Gly Ala Asn Ile Leu Tyr
90 95 100GCT ATC AAT GAC TAT GGC CGT GTT TTA AGG GAC TCT TGT GAA GCG GGA 390Ala Ile Asn Asp Tyr Gly Arg Val Leu Arg Asp Ser Cys Glu Ala Gly
105 110 115GCG AAT ATC ATT ATT ACA GGG GCT GGT TTG CCC ACC AAC ATG CCT GAA 438Ala Asn Ile Ile Ile Thr Gly Ala Gly Leu Pro Thr Asn Met Pro Glu
120 125 130TTC GCT AAG GAT TTT AGC GAT GTG GCG CTC ATC CCT ATT ATT TCT TCA 486Phe Ala Lys Asp Phe Ser Asp Val Ala Leu Ile Pro Ile Ile Ser Ser135 140 145 150GCG AAG GCT TTA AAA ATC CTT TGT AAA AGA TGG AGC GAT CGC TAT AAA 534Ala Lys Ala Leu Lys Ile Leu Cys Lys Arg Trp Ser Asp Arg Tyr Lys
155 160 165AGA ATC CCG GAC GCG TTC ATT GTG GAA GGG CCT TTG AGT GGG GGG CAT 582Arg Ile Pro Asp Ala Phe Ile Val Glu Gly Pro Leu Ser Gly Gly His
170 175 180CAG GGC TTT AAA TAG GAA GAT TGT TTC AAA GAA GAA TTC CGA TTA GAA 630Gln Gly Phe Lys Tyr Glu Asp Cys Phe Lys Glu Glu Phe Arg Leu Glu
185 190 195AAC TTA GTG CCT AAA GTC GTG GAA GCT TCT AAA GAA TGG GGG AAT ATC 678Asn Leu Val Pro Lys Val Val Glu Ala Ser Lys Glu Trp Gly Asn Ile
200 205 210CCT ATC ATC GCC GCT GGG GGG ATT TGG GAT AGG AAG GAT ATA GAC ACC 726Pro Ile Ile Ala Ala Gly GlyIle Trp Asp Arg Lys Asp Ile Asp Thr215 220 225 230ATG TTA AGT CTT GGA GCG AGT GGG GTG CAG ATG GCG ACT CGT TTT TTA 774Met Leu Ser Leu Gly Ala Ser Gly Val Gln Met Ala Thr Arg Phe Leu
235 240 245GGC ACG AAA GAA TGC GAC GCT AAA GTG TAT GCC GAT CTT TTG CCC ACG 822Gly Thr Lys Glu Cys Asp Ala Lys Val Tyr Ala Asp Leu Leu Pro Thr
250 255 260CTC AAA AAA GAA GAT ATT TTA CTC ATT AAA TCG CCT GTA GGT TAT CCG 870Leu Lys Lys Glu Asp Ile Leu Leu Ile Lys Ser Pro Val Gly Tyr Pro
265 270 275GCT AGG GCT ATT AAT ACG GGA GTG ATC AAG CGC ATT GAA GAG GGT AAC 918Ala Arg Ala Ile Asn Thr Gly Val Ile Lys Arg Ile Glu Glu Gly Asn
280 285 290GCG CCC AAA ATC GCA TGC GTG AGC AAT TGT GTA GCG CCT TGC AAC AGG 966Ala Pro Lys Ile Ala Cys Val Ser Asn Cys Val Ala Pro Cys Asn Arg295 300 305 310GGT GAA GAG GCT AAA AAG GTG GGC TAT TGT ATC GCT GAT GGT TTG GGG 1014Gly Glu Glu Ala Lys Lys Val Gly Tyr Cys Ile Ala Asp Gly Leu Gly
315 320 325CGC AGT TAT TTA GGG AAC AGA GAA GAG GGG CTT TAT TTT ACC GGG GCT 1062Arg Ser Tyr Leu Gly Asn Arg Glu Glu Gly Leu Tyr Phe Thr Gly Ala
330 335 340AAT GGC TAT AGA GTG GAT AAG ATT ATC AGC GTG CAT GAA TTG ATT AAA 1110Asn Gly Tyr Arg Val Asp Lys Ile Ile Ser Val His Glu Leu Ile Lys
345 350 355GAG CTT ACA GAG GGT TAATTTGTAG TGCTTGTGAG GTTAGGGGTT GTTGCA 1161Glu Leu Thr Glu Gly
360
(2) Sequence 844 data:
(i) sequence characteristics:
(A) length: 363 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 844: met Val Ser Thr Leu Lys Pro Leu Lys Ile Gly Lys His Thr Ile Lys 151015 Phe Pro Ile Phe Gln Gly Gly Met Gly Val Gly Ile Ser Trp Asp Glu
20 25 30Leu Ala Gly Asn Val Ala Lys Glu Gly Ala Leu Gly Val Ile Ser Ala
35 40 45Val Gly Thr Gly Tyr Tyr Lys Asn Met Arg Phe Val Glu Arg Ile Val
50 55 60Ala Lys Lys Pro Phe Glu Ala Leu Asn Phe Tyr Ser Lys Lys Ala Leu65 70 75 80Asn Glu Ile Phe Ala Asn Ala Arg Lys Ile Cys Gly Asn Asn Pro Leu
85 90 95Gly Ala Asn Ile Leu Tyr Ala Ile Asn Asp Tyr Gly Arg Val Leu Arg
100 105 110Asp Ser Cys Glu Ala Gly Ala Asn Ile IleIle Thr Gly Ala Gly Leu
115 120 125Pro Thr Asn Met Pro Glu Phe Ala Lys Asp Phe Ser Asp Val Ala Leu
130 135 140Ile Pro Ile Ile Ser Ser Ala Lys Ala Leu Lys Ile Leu Cys Lys Arg145 150 155 160Trp Ser Asp Arg Tyr Lys Arg Ile Pro Asp Ala Phe Ile Val Glu Gly
165 170 175Pro Leu Ser Gly Gly His Gln Gly Phe Lys Tyr Glu Asp Cys Phe Lys
180 185 190Glu Glu Phe Arg Leu Glu Asn Leu Val Pro Lys Val Val Glu Ala Ser
195 200 205Lys Glu Trp Gly Asn Ile Pro Ile Ile Ala Ala Gly Gly Ile Trp Asp
210 215 220Arg Lys Asp Ile Asp Thr Met Leu Ser Leu Gly Ala Ser Gly Val Gln225 230 235 240Met Ala Thr Arg Phe Leu Gly Thr Lys Glu Cys Asp Ala Lys Val Tyr
245 250 255Ala Asp Leu Leu Pro Thr Leu Lys Lys Glu Asp Ile Leu Leu Ile Lys
260 265 270Ser Pro Val Gly Tyr Pro Ala Arg Ala Ile Asn Thr Gly Val Ile Lys
275 280 285Arg Ile Glu Glu Gly Asn Ala Pro Lys Ile Ala Cys Val Ser Asn Cys
290 295 300Val Ala Pro Cys Asn Arg Gly Glu Glu Ala Lys Lys Val Gly Tyr Cys305 310 315 320Ile Ala Asp Gly Leu Gly Arg Ser Tyr Leu Gly Asn Arg Glu Glu Gly
325 330 335Leu Tyr Phe Thr Gly Ala Asn Gly Tyr Arg Val Asp Lys Ile Ile Ser
340 345 350Val His Glu Leu Ile Lys Glu Leu Thr Glu Gly
355 360
(2) Sequence 845 data:
(i) sequence characteristics:
(A) length: 2373bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 13...2337
(D) Other information:
(xi) Description of the sequence: sequence 845: TAGACAGGAT AG ATG AAC GAA ATT GAT AAA TCC GTT GAT ATC GGA TTC TTA 51
Met Asn Glu Ile Asp Lys Ser Val Asp Ile Gly Phe Leu
1 5 10CGG ATT CTT GAT GTT ATT AAA AAA GTT ACG ACC CCA AAG GGT GGC ATT 99Arg Ile Leu Asp Val Ile Lys Lys Val Thr Thr Pro Lys Gly Gly Ile
15 20 25GAA ATC TTA AGG ACT TTA ATT GAT TTT ACG CCC AAA ATT GAA AAC GCC 147Glu Ile Leu Arg Thr Leu Ile Asp Phe Thr Pro Lys Ile Glu Asn Ala30 35 40 45CTG AAT TTA GCG GCC AAA AGC CAT AAG GGG CAA TAC AGA AAA AGC GGC 195Leu Asn Leu Ala Ala Lys Ser His Lys Gly Gln Tyr Arg Lys Ser Gly
50 55 60GAG CCT TAT ATT GTC CAT CCT ATT TGC GTG GCA AGC TTG GTA GCG TTT 243Glu Pro Tyr Ile Val His Pro Ile Cys Val Ala Ser Leu Val Ala Phe
65 70 75TGT GGG GGC GAT GAG GCG ATG GTG TGT GCT GCG CTT TTG CAT GAT GTG 291Cys Gly Gly Asp Glu Ala Met Val Cys Ala Ala Leu Leu His Asp Val
80 85 90GTG GAA GAC ACG CCT TGT AAG ATT GAA ACG ATT GAG CAA GAA TTT GGG 339Val Glu Asp Thr Pro Cys Lys Ile Glu Thr Ile Glu Gln Glu Phe Gly
95 100105CAA GAT GTG GCT AAT TTA GTG GAT GCG CTC ACT AAA ATC ACT GAA ATC 387Gln Asp Val Ala Asn Leu Val Asp Ala Leu Thr Lys Ile Thr Glu Ile110 115 120 125AGG AAA GAA GAA TTA GGC GTG AGC TCT CAA GAT CCC AGA ATG GTG GTT 435Arg Lys Glu Glu Leu Gly Val Ser Ser Gln Asp Pro Arg Met Val Val
130 135 140TCA GCG CTC ACT TTC AGA AAG ATT TTA ATT AGC GCG ATA CAA GAT CCA 483Ser Ala Leu Thr Phe Arg Lys Ile Leu Ile Ser Ala Ile Gln Asp Pro
145 150 155AGA GCC TTA GTG GTA AAG ATT AGC GAC AGG TTG CAC AAC ATG CTC ACC 531Arg Ala Leu Val Val Lys Ile Ser Asp Arg Leu His Asn Met Leu Thr
160 165 170TTA GAC GCC TTG CCT CAT GAC AAG CAA GTG CGT ATT TCT AAA GAG ACT 579Leu Asp Ala Leu Pro His Asp Lys Gln Val Arg Ile Ser Lys Glu Thr
175 180 185CTA GCG GTG TAT GCC CCT ATA GCG AGC CGA TTG GGC ATG TCT TCA ATC 627Leu Ala Val Tyr Ala Pro Ile Ala Ser Arg Leu Gly Met Ser Ser Ile190 195 200 205AAA AAT GAA TTA GAA GAC AAG AGC TTT TAT TAT ATT TAT CCA GAA GAG 675Lys Asn Glu Leu Glu Asp Lys Ser Phe Tyr Tyr Ile Tyr Pro Glu Glu
210 215 220TAT AAA AAT ATC AAG GAA TAT TTG CAC AAA AAC AAG CAG TCT TTA CTC 723Tyr Lys Asn Ile Lys Glu Tyr Leu His Lys Asn Lys Gln Ser Leu Leu
225 230 235TTA AAG CTC AAC GCT TTT GCG AGC AAG TTA GAA AAA AAA CTT TTT GAT 771Leu Lys Leu Asn Ala Phe Ala Ser Lys Leu Glu Lys Lys Leu Phe Asp
240 245 250AGT GGG TTT AGC CAT TCG GAT TTT AAA CTC GTT ACA AGG GTG AAA CGC819Ser Gly Phe Ser His Ser Asp Phe Lys Leu Val Thr Arg Val Lys Arg
255 260 265CCT TAT TCT ATC TAT CTT AAG ATG CAA CGA AAG GGC GCG GTT AAT ATT 867Pro Tyr Ser Ile Tyr Leu Lys Met Gln Arg Lys Gly Ala Val Asn Ile270 275 280 285GAT GAA ATT TTG GAC TTG TTA GCC ATT AGG ATT TTA TTG AAA AAC CCG 915Asp Glu Ile Leu Asp Leu Leu Ala Ile Arg Ile Leu Leu Lys Asn Pro
290 295 300ATT GAT TGC TAT AAA GTT TTA GGG ATT ATC CAT TTG AAT TTC AAA CCC 963Ile Asp Cys Tyr Lys Val Leu Gly Ile Ile His Leu Asn Phe Lys Pro
305 310 315ATT GTC TCT CGT TTT AAA GAT TAC ATC GCT TTG CCC AAA GAA AAT GGC 1011Ile Val Ser Arg Phe Lys Asp Tyr Ile Ala Leu Pro Lys Glu Asn Gly
320 325 330TAT AAG ACG ATA CAC ACG ACC ATT TTT GAT GAA TCT TCT GTT TAT GAA 1059Tyr Lys Thr Ile His Thr Thr Ile Phe Asp Glu Ser Ser Val Tyr Glu
335 340 345GTG CAG ATC CGC ACC TTT GAT ATG CAT ATG GGG GCG GAG TAT GGT AAT 1107Val Gln Ile Arg Thr Phe Asp Met His Met Gly Ala Glu Tyr Gly Asn350 355 360 365TCA GCC CAC TGG AAG TAT AAA GCC GGG GGC GTG GAT CAT GAA GAT CAT 1155Ser Ala His Trp Lys Tyr Lys Ala Gly Gly Val Asp His Glu Asp His
370 375 380CAT GAG GGC ATG AGA TGG TTG CAA AAT TTT AAA TAC CAT GAC AGC GAT 1203His Glu Gly Met Arg Trp Leu Gln Asn Phe Lys Tyr His Asp Ser Asp
385 390 395TTG AAA AAC GAC CCT AAG GAA TTT TAC GAA CTC GCT AAG AAC GAT TTG 1251Leu Lys Asn Asp Pro Lys Glu Phe Tyr Glu Leu Ala Lys Asn Asp Leu
400 405 410TAT CGT GAA GAT ATT GTC GTT TTT TCG CCT CAT GGG GAC ACT TAC ACT 1299Tyr Arg Glu Asp Ile Val Val Phe Ser Pro His Gly Asp Thr Tyr Thr
415 420 425TTA CCG GTG GGT GCG ATC GCT TTA GAT TTT GCT TAC ATG GTG CAT AGC 1347Leu Pro Val Gly Ala Ile Ala Leu Asp Phe Ala Tyr Met Val His Ser430 435 440 445GAT TTG GGC GAT AAA GCC ACG GAC GCT TAT ATC AAT AGT AAA AAA GCC 1395Asp Leu Gly Asp Lys Ala Thr Asp Ala Tyr Ile Asn Ser Lys Lys Ala
450 455 460TTA CTC AAT CAG GAA TTA AGA AGT GGG GAT GTG GTT AAA ATC ATT AAA 1443Leu Leu Asn Gln Glu Leu Arg Ser Gly Asp Val Val Lys Ile Ile Lys
465 470 475GGC GAT AAA ATA ATA CCT CGT TTC ATT TGG ATG GAT CAG CTT AAA ACT 1491Gly Asp Lys Ile Ile Pro Arg Phe Ile Trp Met Asp Gln Leu Lys Thr
480 485 490TCT AAG GCT AAA AAC CAT TTG CGC ATC CAA AGA AGA AAC CGC TTG AAA 1539Ser Lys Ala Lys Asn His Leu Arg Ile Gln Arg Arg Asn Arg Leu Lys
495 500 505GAG GTT GAC ACT AAG AGC ATG ATC AAT ATC TTA GCG ACT TTT TTT GGG 1587Glu Val Asp Thr Lys Ser Met Ile Asn Ile Leu Ala Thr Phe Phe Gly510 515 520 525CGC TCT GTT TTT GAA GAC ATG GAT TTA AAG GAT TAT AAA AAC TTT GAA 1635Arg Ser Val Phe Glu Asp Met Asp Leu Lys Asp Tyr Lys Asn Phe Glu
530 535 540GAA AGA TTA ACA GAT TGC GGG GTG GAG ACC ACC TTA ACA GAA GCG ATG 1683Glu Arg Leu Thr Asp Cys Gly Val Glu Thr Thr Leu Thr Glu Ala Met
545 550 555AAA AGT TTT GAA AAT TTA GCC AAA CTC ACT GAA GAA ATT GAA AAT AAG 1731Lys Ser Phe Glu Asn Leu Ala Lys Leu Thr Glu Glu Ile Glu Asn Lys
560 565 570GTG TTT TCT TTA AAA GAA GAT GCG ATT TTA GAA TAC CAA GAG ATG AGT 1779Val Phe Ser Leu Lys Glu Asp Ala Ile Leu Glu Tyr Gln Glu Met Ser
575 580 585TTA TGG ACT CGA GGT TTA AGG TAT TTG GGC TTT AAA ACC AAT GTC TTG 1827Leu Trp Thr Arg Gly Leu Arg Tyr Leu Gly Phe Lys Thr Asn Val Leu590 595 600 605AAT TTT TTA GCC CCC AAT CGG CAG TGG CAG TGT AAG GAA TTA GAA CAT 1875Asn Phe Leu Ala Pro Asn Arg Gln Trp Gln Cys Lys Glu Leu Glu His
610 615 620TTT AGC GTT TGT TCA AGC AAC GCT TTA GAA ATC AAA CAG GTG TTG TTG 1923Phe Ser Val Cys Ser Ser Asn Ala Leu Glu Ile Lys Gln Val Leu Leu
625 630 635AAT GAT TGT TGT TAC CCT AAA TAT GGC GAT GAA ATC ATT GCG ATT GTA 1971Asn Asp Cys Cys Tyr Pro Lys Tyr Gly Asp Glu Ile Ile Ala Ile Val
640 645 650ACG GAT TTA AAA GAT CCA AAA GCG ATT GCG CAC CAT AAA TTT TGC AAA 2019Thr Asp Leu Lys Asp Pro Lys Ala Ile Ala His His Lys Phe Cys Lys
655 660 665AAA GCG ATG GCG GAA GTA GAT GCT AAA GTG CCT ATG GTT TAT ATA GAA 2067Lys Ala Met Ala Glu Val Asp Ala Lys Val Pro Met Val Tyr Ile Glu670 675 680 685TGG CAC AAG CGG GAT CGA ACG ATT TAT AAA ATG ATG TTT TAT TTG GGC 2115Trp His Lys Arg Asp Arg Thr Ile Tyr Lys Met Met Phe Tyr Leu Gly
690 695 700GAA AAA AAG TCG GTT TTA GCG GGT TTA TTA ACT TTT TTA AAC AGG AAT 2163Glu Lys Lys Ser Val Leu Ala Gly Leu Leu Thr Phe Leu Asn Arg Asn
705 710 715GAA TGC AAC ATT GTG GGC GTG TCT TAT TTG GGC TAT AAA GAC AAG TAT 2211Glu Cys Asn Ile Val Gly Val Ser Tyr Leu Gly Tyr Lys Asp Lys Tyr
720 725 730TCT AGC CAT TGT GAA GTG AGT TTT GAA ATA GCC ACA GAT AAG GCG GAT 2259Ser Ser His Cys Glu Val Ser Phe Glu Ile Ala Thr Asp Lys Ala Asp
735 740 745TGG ATC AGA GCC TTA ATC AAT CGC AAA TAT CAG GAT AGG ATT GTA GAA 2307Trp Ile Arg Ala Leu Ile Asn Arg Lys Tyr Gln Asp Arg Ile Val Glu750 755 760 765TTA TCC AGT CTG GAT GAC GCT TAT GAA TCA TAATAAGCCC TAATTAAGGA ATG 2360Leu Ser Ser Leu Asp Asp Ala Tyr Glu Ser
770 775AACATGGAAC AAA 2373
(2) Sequence 846 data:
(i) sequence characteristics:
(A) length: 775 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 846: met Asn Glu Ile Asp Lys Ser Val Asp Ile Gly Phe Leu Arg Ile Leu 151015 Asp Val Ile Lys Lys Val Thr Thr Pro Lys Gly Gly Ile Glu Ile Leu
20 25 30Arg Thr Leu Ile Asp Phe Thr Pro Lys Ile Glu Asn Ala Leu Asn Leu
35 40 45Ala Ala Lys Ser His Lys Gly Gln Tyr Arg Lys Ser Gly Glu Pro Tyr
5055 60Ile Val His Pro Ile Cys Val Ala Ser Leu Val Ala Phe Cys Gly Gly65 70 75 80Asp Glu Ala Met Val Cys Ala Ala Leu Leu His Asp Val Val Glu Asp
85 90 95Thr Pro Cys Lys Ile Glu Thr Ile Glu Gln Glu Phe Gly Gln Asp Val
100 105 110Ala Asn Leu Val Asp Ala Leu Thr Lys Ile Thr Glu Ile Arg Lys Glu
115 120 125Glu Leu Gly Val Ser Ser Gln Asp Pro Arg Met Val Val Ser Ala Leu
130 135 140Thr Phe Arg Lys Ile Leu Ile Ser Ala Ile Gln Asp Pro Arg Ala Leu145 150 155 160Val Val Lys Ile Ser Asp Arg Leu His Asn Met Leu Thr Leu Asp Ala
165 170 175Leu Pro His Asp Lys Gln Val Arg Ile Ser Lys Glu Thr Leu Ala Val
180 185 190Tyr Ala Pro Ile Ala Ser Arg Leu Gly Met Ser Ser Ile Lys Asn Glu
195 200 205Leu Glu Asp Lys Ser Phe Tyr Tyr Ile Tyr Pro Glu Glu Tyr Lys Asn
210 215 220Ile Lys Glu Tyr Leu His Lys Asn Lys Gln Ser Leu Leu Leu Lys Leu225 230 235 240Asn Ala Phe Ala Ser Lys Leu Glu Lys Lys Leu Phe Asp Ser Gly Phe
245 250 255Ser His Ser Asp Phe Lys Leu Val Thr Arg Val Lys Arg Pro Tyr Ser
260 265 270Ile Tyr Leu Lys Met Gln Arg Lys Gly Ala Val Asn Ile Asp Glu Ile
275 280 285Leu Asp Leu Leu Ala Ile Arg Ile Leu Leu Lys Asn Pro Ile Asp Cys
290 295 300Tyr Lys Val Leu Gly Ile Ile His Leu Asn Phe Lys Pro Ile Val Ser305 310 315 320Arg Phe Lys Asp Tyr Ile Ala Leu Pro Lys Glu Asn Gly Tyr Lys Thr
325 330 335Ile His Thr Thr Ile Phe Asp Glu Ser Ser Val Tyr Glu Val Gln Ile
340 345 350Arg Thr Phe Asp Met His Met Gly Ala Glu Tyr Gly Asn Ser Ala His
355 360 365Trp Lys Tyr Lys Ala Gly Gly Val Asp His Glu Asp His His Glu Gly
370 375 380Met Arg Trp Leu Gln Asn Phe Lys Tyr His Asp Ser Asp Leu Lys Asn385 390 395 400Asp Pro Lys Glu Phe Tyr Glu Leu Ala Lys Asn Asp Leu Tyr Arg Glu
405 410 415Asp Ile Val Val Phe Ser Pro His Gly Asp Thr Tyr Thr Leu Pro Val
420 425 430Gly Ala Ile Ala Leu Asp Phe Ala Tyr Met Val His Ser Asp Leu Gly
435 440 445Asp Lys Ala Thr Asp Ala Tyr Ile Asn Ser Lys Lys Ala Leu Leu Asn
450 455 460Gln Glu Leu Arg Ser Gly Asp Val Val Lys Ile Ile Lys Gly Asp Lys465 470 475 480Ile Ile Pro Arg Phe Ile Trp Met Asp Gln Leu Lys Thr Ser Lys Ala
485 490 495Lys Asn His Leu Arg Ile Gln Arg Arg Asn Arg Leu Lys Glu Val Asp
500505 510Thr Lys Ser Met Ile Asn Ile Leu Ala Thr Phe Phe Gly Arg Ser Val
515 520 525Phe Glu Asp Met Asp Leu Lys Asp Tyr Lys Asn Phe Glu Glu Arg Leu
530 535 540Thr Asp Cys Gly Val Glu Thr Thr Leu Thr Glu Ala Met Lys Ser Phe545 550 555 560Glu Asn Leu Ala Lys Leu Thr Glu Glu Ile Glu Asn Lys Val Phe Ser
565 570 575Leu Lys Glu Asp Ala Ile Leu Glu Tyr Gln Glu Met Ser Leu Trp Thr
580 585 590Arg Gly Leu Arg Tyr Leu Gly Phe Lys Thr Asn Val Leu Asn Phe Leu
595 600 605Ala Pro Asn Arg Gln Trp Gln Cys Lys Glu Leu Glu His Phe Ser Val
610 615 620Cys Ser Ser Asn Ala Leu Glu Ile Lys Gln Val Leu Leu Asn Asp Cys625 630 635 640Cys Tyr Pro Lys Tyr Gly Asp Glu Ile Ile Ala Ile Val Thr Asp Leu
645 650 655Lys Asp Pro Lys Ala Ile Ala His His Lys Phe Cys Lys Lys Ala Met
660 665 670Ala Glu Val Asp Ala Lys Val Pro Met Val Tyr Ile Glu Trp His Lys
675 680 685Arg Asp Arg Thr Ile Tyr Lys Met Met Phe Tyr Leu Gly Glu Lys Lys
690 695 700Ser Val Leu Ala Gly Leu Leu Thr Phe Leu Asn Arg Asn Glu Cys Asn705 710 715 720Ile Val Gly Val Ser Tyr Leu Gly Tyr Lys Asp Lys Tyr Ser Ser His
725730 735Cys Glu Val Ser Phe Glu Ile Ala Thr Asp Lys Ala Asp Trp Ile Arg
740 745 750Ala Leu Ile Asn Arg Lys Tyr Gln Asp Arg Ile Val Glu Leu Ser Ser
755 760 765Leu Asp Asp Ala Tyr Glu Ser
770 775
(2) Data of sequence 847:
(i) sequence characteristics:
(A) length: 310bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 10...279
(D) Other information:
(xi) Description of the sequence: sequence 847: AAAAGGAGA GTG GCG GTG AAA AAA ATC GTT GTG AGT TGG TGT GTG GCG TTG 51
Val Ala Val Lys Lys Ile Val Val Ser Trp Cys Val Ala Leu
1 5 10GCT TTT TTA AGC GCG GAT TCA GCA CAA GCC AAT AAA GCG ATC AGT AAT 99Ala Phe Leu Ser Ala Asp Ser Ala Gln Ala Asn Lys Ala Ile Ser Asn15 20 25 30GCG GAT TTG ATT AAA GAG ATA AGG GAT TTA AAA AAA ATC ATC AGC GCG 147Ala Asp Leu Ile Lys Glu Ile Arg Asp Leu Lys Lys Ile Ile Ser Ala
35 40 45CAA AAC ACT GAG ATT AAC AAC TTA AGA AAA GTG CAA GAA GTG TTG TCT 195Gln Asn Thr Glu Ile Asn Asn Leu Arg Lys Val GlnGlu Val Leu Ser
50 55 60GGG CAA TTA GGG GAC ATG CGT AAG GAT ATA TTA AGC ACT AGA GAT TAT 243Gly Gln Leu Gly Asp Met Arg Lys Asp Ile Leu Ser Thr Arg Asp Tyr
65 70 75TGC ATT AGC TTA AGG CCT TAT ATC TAT AAT TGG CGC TAGGGGATAA TCCAAA 295Cys Ile Ser Leu Arg Pro Tyr Ile Tyr Asn Trp Arg
80 85 90AAATGAAAGC ATGCG 310
(2) Sequence 848 data:
(i) sequence characteristics:
(A) length: 90 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 848: val Ala Val Lys Lys Ile Val Val Ser Trp Cys Val Ala Leu Ala Phe 151015 Leu Ser Ala Asp Ser Ala Gln Ala Asn Lys Ala Ile Ser Asn Ala Asp
20 25 30Leu Ile Lys Glu Ile Arg Asp Leu Lys Lys Ile Ile Ser Ala Gln Asn
35 40 45Thr Glu Ile Asn Asn Leu Arg Lys Val Gln Glu Val Leu Ser Gly Gln
50 55 60Leu Gly Asp Met Arg Lys Asp Ile Leu Ser Thr Arg Asp Tyr Cys Ile65 70 75 80Ser Leu Arg Pro Tyr Ile Tyr Asn Trp Arg
85 90
(2) Data of sequence 849:
(i) sequence characteristics:
(A) length: 1631bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...1569
(D) Other information:
(xi) Description of the sequence: sequence 849: TGAAAAAGAA CTCAAAGAGC TGCAAAAAAA ACAAAAACAC GAGTAACAAC C ATG ATT 57
Met Ile
1AAC ACG ATG TTT TGC GCG ACC ATG CAA AGG GGA GTG GCG GAA ATC GTG 105Asn Thr Met Phe Cys Ala Thr Met Gln Arg Gly Val Ala Glu Ile Val
5 10 15GCT GTG GAA GCG ACT TTC ACA AGG GCT TTG CCG GCG TTT GTG ATT TCA 153Ala Val Glu Ala Thr Phe Thr Arg Ala Leu Pro Ala Phe Val Ile Ser
20 25 30GGG TTA GCT AAT AGC TCT ATC CAA GAA GCC AAA CAG CGG GTT CAA TCG 201Gly Leu Ala Asn Ser Ser Ile Gln Glu Ala Lys Gln Arg Val Gln Ser35 40 45 50GCT TTA CAA AAT AAC GAT TTC ACT TTC CCG CCT TTA AAA ATC ACC ATC 249Ala Leu Gln Asn Asn Asp Phe Thr Phe Pro Pro Leu Lys Ile Thr Ile
55 60 65AAC CTT TCC CCC TCA GAT TTG CCT AAA TCC GGG AGT CAT TTT GAT TTG 297Asn Leu Ser Pro Ser Asp Leu Pro Lys Ser Gly Ser His Phe Asp Leu
70 75 80CCT ATC GCT CTT TTA ATC GCT TTG CAA AAA CAA GAG TTG GCT TTT AAA 345Pro Ile Ala Leu Leu Ile Ala Leu Gln Lys Gln Glu Leu Ala Phe Lys
85 90 95GAG TGG TTT GCT TTT GGG GAG TTA GGG CTT GAT GGC AAG ATC AAA CCC 393Glu Trp Phe Ala Phe Gly Glu Leu Gly Leu Asp Gly Lys Ile Lys Pro
100 105 110AAT CCT AAC ATT TTC CCC ATG CTT TTA GAC ATT GCC ATT AAA CAC CCC 441Asn Pro Asn Ile Phe Pro Met Leu Leu Asp Ile Ala Ile Lys His Pro115 120 125 130CAT GCT AAG ATC ATT GCG CCT AAG GCC AAT GAA GAG CTT TTT TCG CTT 489His Ala Lys Ile Ile Ala Pro Lys Ala Asn Glu Glu Leu Phe Ser Leu
135 140 145ATC CCT AAT TTG CAA TGC TTT TTT GTG GGG CAT TTT AAA GAA GCG TTA 537Ile Pro Asn Leu Gln Cys Phe Phe Val Gly His Phe Lys Glu Ala Leu
150 155 160GAA ATC TTG CAA AAC CCT GAA ACC AAA GCA GAC ACC CAC ACG AAA AAA 585Glu Ile Leu Gln Asn Pro Glu Thr Lys Ala Asp Thr His Thr Lys Lys
165 170 175CTA CCC TTT AAA ACG ATA GAA TTG AAC GAT AAA GAG TAT TAT TTT TCA 633Leu Pro Phe Lys Thr Ile Glu Leu Asn Asp Lys Glu Tyr Tyr Phe Ser
180 185 190GAC GCC TAT GCC TTA GAT TTT AAA GAA GTT AAG GGG CAA GCT GTC GCT 681Asp Ala Tyr Ala Leu Asp Phe Lys Glu Val Lys Gly Gln Ala Val Ala195 200 205 210AAA GAG GCC GCT TTG ATC GCT AGC GCT GGG TTT CAT AAC TTG ATT TTA 729Lys Glu Ala Ala Leu Ile Ala Ser Ala Gly Phe His Asn Leu Ile Leu
215 220 225GAG GGA AGT CCA GGG TGT GGG AAA AGC ATG ATC ATT AAT CGC ATG CGT 777Glu Gly Ser Pro Gly Cys Gly Lys Ser Met Ile Ile Asn Arg Met Arg
230 235 240TAT ATC TTG CCT CCA TTA AGC CTG AAT GAA ATC CTA GAA GCG ACA AAA 825Tyr Ile Leu Pro Pro Leu Ser Leu Asn Glu Ile Leu Glu Ala Thr Lys
245 250 255TTA CGC ATT TTA AGC GAG CAA GAC AGT GCC TAT TAC CCC TTA AGG AGT 873Leu Arg Ile Leu Ser Glu Gln Asp Ser Ala Tyr Tyr Pro Leu Arg Ser
260 265 270TTT AGA AAC CCT CAC CAA AGC GCT TCA AAA TCC AGT ATT TTA GGC TCA 921Phe Arg Asn Pro His Gln Ser Ala Ser Lys Ser Ser Ile Leu Gly Ser275 280 285 290AGC TCT CTA AGA GAG CCA AAA CCT GGC GAA ATC GCG CTA GCG CAT AAC 969Ser Ser Leu Arg Glu Pro Lys Pro Gly Glu Ile Ala Leu Ala His Asn
295 300 305GGC ATG CTT TTT TTT GAT GAA TTG CCT CAT TTT AAA AAG GAT ATT TTG 1017Gly Met Leu Phe Phe Asp Glu Leu Pro His Phe Lys Lys Asp Ile Leu
310 315 320GAA GCT TTA AGA GAG CCT TTA GAA AAC AAT AAA TTG GTG GTT TCA AGA 1065Glu Ala Leu Arg Glu Pro Leu Glu Asn Asn Lys Leu Val Val Ser Arg
325 330 335GTG CAT AGC AAA ATT GAA TAC GAA ACC TCT TTT TTA TTT GTA GGG GCT 1113Val His Ser Lys Ile Glu Tyr Glu Thr Ser Phe Leu Phe Val Gly Ala
340 345 350CAA AAC CCT TGC TTG TGC GGG AAT TTA CTC AGC GCG ACC AAA GCA TGC 1161Gln Asn Pro Cys Leu Cys Gly Asn Leu Leu Ser Ala Thr Lys Ala Cys355 360 365 370CGT TGC CAA GAC AGA GAA ATC ACG CAG TAT AAA AAC CGC TTG AGC GAG 1209Arg Cys Gln Asp Arg Glu Ile Thr Gln Tyr Lys Asn Arg Leu Ser Glu
375 380 385CCT TTT TTG GAT AGG ATT GAT TTG TTT GTG CAA ATG GAA GAG GGG AAT 1257Pro Phe Leu Asp Arg Ile Asp Leu Phe Val Gln Met Glu Glu Gly Asn
390 395 400TAT AAA GAC ACG CCG TCG CAT TCT TGG ACT TCA AAA GAG ATG CAT GAA 1305Tyr Lys Asp Thr Pro Ser His Ser Trp Thr Ser Lys Glu Met His Glu
405 410 415TTG GTG TTA TTA GCT TTC AAG CAG CAA AAG TTA AGG AAA CAG AGC GTT 1353Leu Val Leu Leu Ala Phe Lys Gln Gln Lys Leu Arg Lys Gln Ser Val
420 425 430TTT AAT GGT AAG CTT AAT GAA GAG CAG ATA GAA CGA TTT TGC CCC TTA 1401Phe Asn Gly Lys Leu Asn Glu Glu Gln Ile Glu Arg Phe Cys Pro Leu435 440 445 450AAC GCT GAA GCA AAA AAG TTG TTG GAG CAG GCG GTT GAA AGG TTT AAT 1449Asn Ala Glu Ala Lys Lys Leu Leu Glu Gln Ala Val Glu Arg Phe Asn
455 460 465CTC TCC ATG CGC TCT ATT AAT AAG GTC AAA AAA GTC GCT AGG ACG ATT 1497Leu Ser Met Arg Ser Ile Asn Lys Val Lys Lys Val Ala Arg Thr Ile
470 475 480GCG GAT TTA AAC GCT TGC GAG GAT ATA GAA AAA TCT CAC ATG CTT AAA 1545Ala Asp Leu Asn Ala Cys Glu Asp Ile Glu Lys Ser His Met Leu Lys
485 490 495GCG CTG AGT TTT AGA AAG ATT TCT TAAAAGGATT TTTATAAGGG AGAAAAAATG 1599Ala Leu Ser Phe Arg Lys Ile Ser
500 505CAAGAATACC ACATTCATAA TTTGGATTGC CC 1631
(2) Sequence 850 data:
(i) sequence characteristics:
(A) length: 506 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 850: met Ile Asn Thr Met Phe Cys Ala Thr Met Gln Arg Gly Val Ala Glu 151015 Ile Val Ala Val Glu Ala Thr Phe Thr Arg Ala Leu Pro Ala Phe Val
20 25 30Ile Ser Gly Leu Ala Asn Ser Ser Ile Gln Glu Ala Lys Gln Arg Val
35 40 45Gln Ser Ala Leu Gln Asn Asn Asp Phe Thr Phe Pro Pro Leu Lys Ile
50 55 60Thr Ile Asn Leu Ser Pro Ser Asp Leu Pro Lys Ser Gly Ser His Phe65 70 75 80Asp Leu Pro Ile Ala Leu Leu Ile Ala Leu Gln Lys Gln Glu Leu Ala
85 90 95Phe Lys Glu Trp Phe Ala Phe Gly Glu Leu Gly Leu Asp Gly Lys Ile
100 105 110Lys Pro Asn Pro Asn Ile Phe Pro Met Leu Leu Asp Ile Ala Ile Lys
115 120 125His Pro His Ala Lys Ile Ile Ala Pro Lys Ala Asn Glu Glu Leu Phe
130 135 140Ser Leu Ile Pro Asn Leu Gln Cys Phe Phe Val Gly His Phe Lys Glu145 150 155 160Ala Leu Glu Ile Leu Gln Asn Pro Glu Thr Lys Ala Asp Thr His Thr
165 170 175Lys Lys Leu Pro Phe Lys Thr Ile Glu Leu Asn Asp Lys Glu Tyr Tyr
180 185 190Phe Ser Asp Ala Tyr Ala Leu Asp Phe Lys Glu Val Lys Gly Gln Ala
195 200 205Val Ala Lys Glu Ala Ala Leu Ile Ala Ser Ala Gly Phe His Asn Leu
210 215 220Ile Leu Glu Gly Ser Pro Gly Cys Gly Lys Ser Met Ile Ile Asn Arg225 230 235 240Met Arg Tyr Ile Leu Pro Pro Leu Ser Leu Asn Glu Ile Leu Glu Ala
245 250 255Thr Lys Leu Arg Ile Leu Ser Glu Gln Asp Ser Ala Tyr Tyr Pro Leu
260 265 270Arg Ser Phe Arg Asn Pro His Gln Ser Ala Ser Lys Ser Ser Ile Leu
275 280 285Gly Ser Ser Ser Leu Arg Glu Pro Lys Pro Gly Glu Ile Ala Leu Ala
290 295 300His Asn Gly Met Leu Phe Phe Asp Glu Leu Pro His Phe Lys Lys Asp305 310 315 320Ile Leu Glu Ala Leu Arg Glu Pro Leu Glu Asn Asn Lys Leu Val Val
325 330 335Ser Arg Val His Ser Lys Ile Glu Tyr Glu Thr Ser Phe Leu Phe Val
340 345 350Gly Ala Gln Asn Pro Cys Leu Cys Gly Asn Leu Leu Ser Ala Thr Lys
355 360 365Ala Cys Arg Cys Gln Asp Arg Glu Ile Thr Gln Tyr Lys Asn Arg Leu
370 375 380Ser Glu Pro Phe Leu Asp Arg Ile Asp Leu Phe Val Gln Met Glu Glu385 390 395 400Gly Asn Tyr Lys Asp Thr Pro Ser His Ser Trp Thr Ser Lys Glu Met
405 410 415His Glu Leu Val Leu Leu Ala Phe Lys Gln Gln Lys Leu ArgLys Gln
420 425 430Ser Val Phe Asn Gly Lys Leu Asn Glu Glu Gln Ile Glu Arg Phe Cys
435 440 445Pro Leu Asn Ala Glu Ala Lys Lys Leu Leu Glu Gln Ala Val Glu Arg
450 455 460Phe Asn Leu Ser Met Arg Ser Ile Asn Lys Val Lys Lys Val Ala Arg465 470 475 480Thr Ile Ala Asp Leu Asn Ala Cys Glu Asp Ile Glu Lys Ser His Met
485 490 495Leu Lys Ala Leu Ser Phe Arg Lys Ile Ser
500 505
(2) Sequence 851 data:
(i) sequence characteristics:
(A) length: 605bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 26...547
(D) Other information:
(xi) Description of the sequence: sequence 851: TTACAGAAAA ACGTGAAGTG ATTGC ATG GCG TTA TTA GAG ATT ATC CAT TAC 52
Met Ala Leu Leu Glu Ile Ile His Tyr
1 5CCT TCT AAA ATC TTA AGA ACG ATT TCT AAA GAG GTC GTT TCT TTT GAT 100Pro Ser Lys Ile Leu Arg Thr Ile Ser Lys Glu Val Val Ser Phe Asp10 15 20 25TCA AAA CTC CAC CAA CAG CTA GAT GAC ATG CAT GAG ACT ATG ATC GCT 148Ser Lys Leu His Gln Gln Leu Asp Asp Met His Glu Thr Met Ile Ala
30 35 40AGT GAG GGG ATA GGG TTA GCC GCT ATT CAA GTG GGT TTG CCT TTA AGA 196Ser Glu Gly Ile Gly Leu Ala Ala Ile Gln Val Gly Leu Pro Leu Arg
45 50 55ATG CTC ATC ATC AAC CTC CCG CAA GAA GAC GGC GTG CAA CAC AAA GAA 244Met Leu Ile Ile Asn Leu Pro Gln Glu Asp Gly Val Gln His Lys Glu
60 65 70GAC TGC TTG GAA ATC ATT AAC CCT AAG TTT ATA GAA ACT GGG GGA TCA 292Asp Cys Leu Glu Ile Ile Asn Pro Lys Phe Ile Glu Thr Gly Gly Ser
75 80 85ATG ATG TAT AGA GAA GGG TGC TTG TCT GTG CCG GGA TTT TAC GAA GAA 340Met Met Tyr Arg Glu Gly Cys Leu Ser Val Pro Gly Phe Tyr Glu Glu90 95 100 105GTG GAG CGT TTT GAA AAG GTT AAG ATA GAG TAT CAA AAC CGC TTC GCT 388Val Glu Arg Phe Glu Lys Val Lys Ile Glu Tyr Gln Asn Arg Phe Ala
110 115 120GAA GTG AAA GTT TTA GAA GCG AGC GAG CTT TTA GCG GTA GCC ATT CAG 436Glu Val Lys Val Leu Glu Ala Ser Glu Leu Leu Ala Val Ala Ile Gln
125 130 135CAT GAG ATC GAT CAC CTC AAT GGC GTG TTA TTC GTG GAT AAA TTA TCC 484His Glu Ile Asp His Leu Asn Gly Val Leu Phe Val Asp Lys Leu Ser
140 145 150ATT TTG AAG CGT AAG AAA TTT GAA AAA GAA CTC AAA GAG CTG CAA AAA 532Ile Leu Lys Arg Lys Lys Phe Glu Lys Glu Leu Lys Glu Leu Gln Lys
155 160 165AAA CAA AAA CAC GAG TAACAACCAT GATTAACACG ATGTTTTGCG CGACCATGCA A 588Lys Gln Lys His Glu170AGGGGAGTGG CGGAAAT 605
(2) Sequence 852 data:
(i) sequence characteristics:
(A) length: 174 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 852: met Ala Leu Leu Glu Ile Ile His Tyr Pro Ser Lys Ile Leu Arg Thr 151015 Ile Ser Lys Glu Val Val Ser Phe Asp Ser Lys Leu His Gln Gln Leu
20 25 30Asp Asp Met His Glu Thr Met Ile Ala Ser Glu Gly Ile Gly Leu Ala
35 40 45Ala Ile Gln Val Gly Leu Pro Leu Arg Met Leu Ile Ile Asn Leu Pro
50 55 60Gln Glu Asp Gly Val Gln His Lys Glu Asp Cys Leu Glu Ile Ile Asn65 70 75 80Pro Lys Phe Ile Glu Thr Gly Gly Ser Met Met Tyr Arg Glu Gly Cys
85 90 95Leu Ser Val Pro Gly Phe Tyr Glu Glu Val Glu Arg Phe Glu Lys Val
100 105 110Lys Ile Glu Tyr Gln Asn Arg Phe Ala Glu Val Lys Val Leu Glu Ala
115 120 125Ser Glu Leu Leu Ala Val Ala Ile Gln His Glu Ile Asp His Leu Asn
130 135 140Gly Val Leu Phe Val Asp Lys Leu Ser Ile Leu Lys Arg Lys Lys Phe145 150 155 160Glu Lys Glu Leu Lys Glu Leu Gln Lys LysGln Lys His Glu
165 170
(2) Sequence 853 data:
(i) sequence characteristics:
(A) length: 564bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 22...495
(D) Other information:
(xi) Description of the sequence: sequence 853: CCCCAAACAA TAGGATAAAA A ATG CCG CTC ACT CAT TTG AAT GAA GAA AAT 51
Met Pro Leu Thr His Leu Asn Glu Glu Asn
1 5 10CAG CCT AAA ATG GTG GAT ATA GGG GAT AAA GAA ACC ACT GAA AGA ATC 99Gln Pro Lys Met Val Asp Ile Gly Asp Lys Glu Thr Thr Glu Arg Ile
15 20 25GCT TTA GCA AGC GGT CGT ATC AGC ATG AAT AAA GAG GCT TAT GAC GCT 147Ala Leu Ala Ser Gly Arg Ile Ser Met Asn Lys Glu Ala Tyr Asp Ala
30 35 40ATT ATC AAT CAT TGC GTC AAA AAG GGT CCG GTG TTA CAG ACT GCT ATT 195Ile Ile Asn His Cys Val Lys Lys Gly Pro Val Leu Gln Thr Ala Ile
45 50 55ATT GCT GGA ATT ATG GGG GCT AAA AAG ACA AGC GAG GTC ATT CCC ATG 243Ile Ala Gly Ile Met Gly Ala Lys Lys Thr Ser Glu Leu Ile Pro Met
60 6570TGC CAT CCA ATC ATG CTC AAT GGG GTG GAT ATT GAT ATT TTA GAA GAA 291Cys His Pro Ile Met Leu Asn Gly Val Asp Ile Asp Ile Leu Glu Glu75 80 85 90AAA GAG ACT TGT AGT TTT AAA CTC TAT GCG AGA GTC AAA ACT CAA GCT 339Lys Glu Thr Cys Ser Phe Lys Leu Tyr Ala Arg Val Lys Thr Gln Ala
95 100 105AAA ACG GGC GTA GAA ATG GAA GCG CTA ATG AGT GTG AGC ATA GGG CTT 387Lys Thr Gly Val Glu Met Glu Ala Leu Met Ser Val Ser Ile Gly Leu
110 115 120TTA ACC ATT TAT GAC ATG GTG AAA GCC ATT GAC AAG AGC ATG ACA ATT 435Leu Thr Ile Tyr Asp Met Val Lys Ala Ile Asp Lys Ser Met Thr Ile
125 130 135AGC GGT GTG ATG TTG GAG CAT AAA AGT GGA GGC AAA AGT GGG GAT TAT 483Ser Gly Val Met Leu Glu His Lys Ser Gly Gly Lys Ser Gly Asp Tyr
140 145 150AAC GCT AAA AAA TAGAAAAAGA CCAATAATCT AAAGATGTTA GGGTAAAATA ACATT 540Asn Ala Lys Lys155TTGACAACAA AAGCGTGTTG GTTG 564
(2) Sequence 854 data:
(i) sequence characteristics:
(A) length: 158 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 854: met Pro Leu Thr His Leu Asn Glu Glu Asn Gln Pro Lys Met Val Asp 151015 Ile Gly Asp Lys Glu Thr Thr Glu Arg Ile Ala Leu Ala Ser Gly Arg
20 25 30Ile Ser Met Asn Lys Glu Ala Tyr Asp Ala Ile Ile Asn His Cys Val
35 40 45Lys Lys Gly Pro Val Leu Gln Thr Ala Ile Ile Ala Gly Ile Met Gly
50 55 60Ala Lys Lys Thr Ser Glu Leu Ile Pro Met Cys His Pro Ile Met Leu65 70 75 80Asn Gly Val Asp Ile Asp Ile Leu Glu Glu Lys Glu Thr Cys Ser Phe
85 90 95Lys Leu Tyr Ala Arg Val Lys Thr Gln Ala Lys Thr Gly Val Glu Met
100 105 110Glu Ala Leu Met Ser Val Ser Ile Gly Leu Leu Thr Ile Tyr Asp Met
115 120 125Val Lys Ala Ile Asp Lys Ser Met Thr Ile Ser Gly Val Met Leu Glu
130 135 140His Lys Ser Gly Gly Lys Ser Gly Asp Tyr Asn Ala Lys Lys145 150 155
(2) Sequence 855 data:
(i) sequence characteristics:
(A) length: 605bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...552
(D) Other information:
(xi) Description of the sequence: sequence 855: CTTTTAGCTT AAAAAGGAGT TCAA ATG CAA ACG ATT CAT ATA GGC GTT TTG 51
Met Gln Thr Ile His Ile Gly Val Leu
1 5AGC GCG AGC GAT AGA GCG TCA AAA GGG ATT TAT GAA GAT TTA AGC GGT 99Ser Ala Ser Asp Arg Ala Ser Lys Gly Ile Tyr Glu Asp Leu Ser Gly10 15 20 25AAG GCG ATA CAA GAA GTG TTG AGC GAA TAC TTG CTC AAT CCT TTA GAA 147Lys Ala Ile Gln Glu Val Leu Ser Glu Tyr Leu Leu Asn Pro Leu Glu
30 35 40TTT TAT TAC GAA ATT GTC GCT GAT GAA AGG GAT TTA ATT GAA AAA TCA 195Phe Tyr Tyr Glu Ile Val Ala Asp Glu Arg Asp Leu Ile Glu Lys Ser
45 50 55CTG ATT AAA ATG TGC GAT GAA TAC CAA TGC GAT CTA GTC GTT ACT ACA 243Leu Ile Lys Met Cys Asp Glu Tyr Gln Cys Asp Leu Val Val Thr Thr
60 65 70GGA GGC ACA GGC CCT GCT TTA AGA GAT ATA ACC CCA GAA GCC ACA GAA 291Gly Gly Thr Gly Pro Ala Leu Arg Asp Ile Thr Pro Glu Ala Thr Glu
75 80 85AAA GTG TGC CAA AAA ATG CTT CCT GGT TTT GGA GAG CTT ATG CGA ATG 339Lys Val Cys Gln Lys Met Leu Pro Gly Phe Gly Glu Leu Met Arg Met90 95 100 105ACT AGT TTA AAA TAT GTG CCT ACA GCG ATC CTG TCG CGC CAG AGC GCT 387Thr Ser Leu Lys Tyr Val Pro Thr Ala Ile Leu Ser Arg Gln Ser Ala
110 115 120GGT ATT AGG AAT AAG AGT TTG ATT ATT AAT CTC CCT GGT AAG CCA AAA 435Gly Ile Arg Asn Lys Ser Leu Ile Ile Asn Leu Pro Gly Lys Pro Lys
125 130 135AGT ATT AGA GAA TGC TTA GAG GCG GTT TTT CCA GCG ATT CCT TAT TGC 483Ser Ile Arg Glu Cys Leu Glu Ala Val Phe Pro Ala Ile Pro Tyr Cys
140 145 150GTG GAT TTG ATT TTA GGG AAT TAT ATG CAA GTG AAT GAA AAA AAC ATT 531Val Asp Leu Ile Leu Gly Asn Tyr Met Gln Val Asn Glu Lys Asn Ile
155 160 165CAA GCG TTT CGC CCC AAA CAA TAGGATAAAA AATGCCGCTC ACTCATTTGA ATGA 586Gln Ala Phe Arg Pro Lys Gln170 175AGAAAATCAG CCTAAAATG 605
(2) Sequence 856 data:
(i) sequence characteristics:
(A) length: 176 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 856: met Gln Thr Ile His Ile Gly Val Leu Ser Ala Ser Asp Arg Ala Ser 151015 Lys Gly Ile Tyr Glu Asp Leu Ser Gly Lys Ala Ile Gln Glu Val Leu
20 25 30Ser Glu Tyr Leu Leu Asn Pro Leu Glu Phe Tyr Tyr Glu Ile Val Ala
35 40 45Asp Glu Arg Asp Leu Ile Glu Lys Ser Leu Ile Lys Met Cys Asp Glu
50 55 60Tyr Gln Cys Asp Leu Val Val Thr Thr Gly Gly Thr Gly Pro Ala Leu65 70 75 80Arg Asp Ile Thr Pro Glu Ala Thr Glu Lys Val Cys Gln Lys Met Leu
85 90 95Pro Gly Phe Gly Glu Leu Met Arg Met Thr Ser Leu Lys Tyr Val Pro
100 105 110Thr Ala Ile Leu Ser Arg Gln Ser Ala Gly Ile Arg Asn Lys Ser Leu
115 120 125Ile Ile Asn Leu Pro Gly Lys Pro Lys Ser Ile Arg Glu Cys Leu Glu
130 135 140Ala Val Phe Pro Ala Ile Pro Tyr Cys Val Asp Leu Ile Leu Gly Asn145 150 155 160Tyr Met Gln Val Asn Glu Lys Asn Ile Gln Ala Phe Arg Pro Lys Gln
165 170 175
(2) Sequence 857 data:
(i) sequence characteristics:
(A) length: 659bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...630
(D) Other information:
(xi) Description of the sequence: sequence 857: GCAATTACTA GAAGAATACA CCCACAAATT ATG CCA AAT CAT CAG CCA GTA AAA 54
Met Pro Asn His Gln Pro Val Lys
1 5AAA TTT AAG ATT ATT GGG GGG GCT TGT AAG GGA TTA GGC TTG AAT TTG 102Lys Phe Lys Ile Ile Gly Gly Ala Cys Lys Gly Leu Gly Leu Asn Leu
10 15 20CCT AAC ATT TCT AGC ACG CGC CCC ACC AAA GCG ATC GTA AGA GAG TCG 150Pro Asn Ile Ser Ser Thr Arg Pro Thr Lys Ala Ile Val Arg Glu Ser25 30 35 40TTT TTT AAC ACC TTG CAA GCA GAA ATT AAT GGA GCG CAT TTT ATA GAA 198Phe Phe Asn Thr Leu Gln Ala Glu Ile Asn Gly Ala His Phe Ile Glu
45 50 55GTG TTT TCA GGC AGC GCT TCT ATG GGT TTA GAG GCT TTG AGT AGG GGG 246Val Phe Ser Gly Ser Ala Ser Met Gly Leu Glu Ala Leu Ser Arg Gly
60 65 70GCT AAA AGT GCG GTG TTT TTT GAA CAA AAC AAA AGC GCT TAT AAG ACG 294Ala Lys Ser Ala Val Phe Phe Glu Gln Asn Lys Ser Ala Tyr Lys Thr
75 80 85CTT TTA GAA AAT ATT TCC CTT TTT AAA AAC CGC TTG AAA AAA GAA ATG 342Leu Leu Glu Asn Ile Ser Leu Phe Lys Asn Arg Leu Lys Lys Glu Met
90 95 100GAA ATT CAA ACC TTT TTA GAT GAC GCT TTC AAG CTT TTG CCC ACG CTG 390Glu Ile Gln Thr Phe Leu Asp Asp Ala Phe Lys Leu Leu Pro Thr Leu105 110 115 120TGT TTA AAA AAT GGC GTT TTG AAT ATT ATT TAT TTG GAT CCT CCT TTT 438Cys Leu Lys Asn Gly Val Leu Asn Ile Ile Tyr Leu Asp Pro Pro Phe
125 130 135GAA ACA AGT GGG TTT TTA GGG ATT TAT GAA AAG TGT TTT CAA GCT TTA 486Glu Thr Ser Gly Phe Leu Gly Ile Tyr Glu Lys Cys Phe Gln Ala Leu
140 145 150GAA AGG TTA TTG AAA CGC TTT AAT CCA AAA AAT CTT TTA GTG GTT TTT 534Glu Arg Leu Leu Lys Arg Phe Asn Pro Lys Asn Leu Leu Val Val Phe
155 160 165GAG CAT GAA AGC ATG CAT GAA ATG CCT AAA AGT CTT GTA ACT TTA GCT 582Glu His Glu Ser Met His Glu Met Pro Lys Ser Leu Val Thr Leu Ala
170 175 180ATA ATC AAA CAA AAA AAA TTT GGA AAA ACC ACT TTA ACT TAT TTT CAA T 631Ile Ile Lys Gln Lys Lys Phe Gly Lys Thr Thr Leu Thr Tyr Phe Gln185 190195 200AGGAATAGGC ATGGCAGAAG AACAAGAA 659
(2) Sequence 858 data:
(i) sequence characteristics:
(A) length: 200 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 858: met Pro Asn His Gln Pro Val Lys Lys Phe Lys Ile Ile Gly Gly Ala 151015 Cys Lys Gly Leu Gly Leu Asn Leu Pro Asn Ile Ser Ser Thr Arg Pro
20 25 30Thr Lys Ala Ile Val Arg Glu Ser Phe Phe Asn Thr Leu Gln Ala Glu
35 40 45Ile Asn Gly Ala His Phe Ile Glu Val Phe Ser Gly Ser Ala Ser Met
50 55 60Gly Leu Glu Ala Leu Ser Arg Gly Ala Lys Ser Ala Val Phe Phe Glu65 70 75 80Gln Asn Lys Ser Ala Tyr Lys Thr Leu Leu Glu Asn Ile Ser Leu Phe
85 90 95Lys Asn Arg Leu Lys Lys Glu Met Glu Ile Gln Thr Phe Leu Asp Asp
100 105 110Ala Phe Lys Leu Leu Pro Thr Leu Cys Leu Lys Asn Gly Val Leu Asn
115 120 125Ile Ile Tyr Leu Asp Pro Pro Phe Glu Thr Ser Gly Phe Leu Gly Ile
130 135 140Tyr Glu Lys Cys Phe Gln Ala Leu Glu Arg Leu Leu Lys Arg Phe Asn145 150 155 160Pro Lys Asn Leu Leu Val Val Phe Glu His Glu Ser Met His Glu Met
165 170 175Pro Lys Ser Leu Val Thr Leu Ala Ile Ile Lys Gln Lys Lys Phe Gly
180 185 190Lys Thr Thr Leu Thr Tyr Phe Gln
195 200
(2) Sequence 859 data:
(i) sequence characteristics:
(A) length: 695bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 26...655
(D) Other information:
(xi) Description of the sequence: sequence 859: CGTGCCTACT TCGCTTTTTG CCGCC ATG ACA GGC ACA CAT GCG CGT TAC GTG 52
Met Thr Gly Thr His Ala Arg Tyr Val
1 5AAA GCC GCT TAC AAA GAG ATA AAA ATT GTT TTT TTA AAC CCT AAA ATC 100Lys Ala Ala Tyr Lys Glu Ile Lys Ile Val Phe Leu Asn Pro Lys Ile10 15 20 25AAT TTA AAC GAA ACC ATC AAA AAT TTA GTG GAA TTA GCC ACT CTG GCT 148Asn Leu Asn Glu Thr Ile Lys Asn Leu Val Glu Leu Ala Thr Leu Ala
30 35 40AGA AAA GAT GGG GTG TTG AGT TTA GAG GGG CGA GTG GCG CAA ATT GAA 196Arg Lys Asp Gly Val Leu Ser Leu Glu Gly Arg Val Ala Gln Ile Glu
45 50 55GAC GAT TTC ACC CGT AAT GGC TTG TCT ATG ATC ATA GAT GGC AAG GAT 244Asp Asp Phe Thr Arg Asn Gly Leu Ser Met Ile Ile Asp Gly Lys Asp
60 65 70TTA AAA TCC GTT AAG GAA AGC TTA GAA ATC AGC ATT GAA GAA ATG GAA 292Leu Lys Ser Val Lys Glu Ser Leu Glu Ile Ser Ile Glu Glu Met Glu
75 80 85GAG TAT TAC CAC GGC GCC GCT CAT TAT TGG GAG ACG GCC GGT GAG ACC 340Glu Tyr Tyr His Gly Ala Ala His Tyr Trp Glu Thr Ala Gly Glu Thr90 95 100 105GCT CCT ACT ATG GGG TTA GTG GGG GCG GTT ATG GGG CTT ATG TTA GCC 388Ala Pro Thr Met Gly Leu Val Gly Ala Val Met Gly Leu Met Leu Ala
110 115 120TTG CAA AAA CTA GAC AAC CCG GCT GAA ATG GCA GCA GGG ATC GCT GGG 436Leu Gln Lys Leu Asp Asn Pro Ala Glu Met Ala Ala Gly Ile Ala Gly
125 130 135GCT TTT ACG GCT ACT GTT ACA GGG ATT ATG TGT TCT TAT GCG ATT TTT 484Ala Phe Thr Ala Thr Val Thr Gly Ile Met Cys Ser Tyr Ala Ile Phe
140 145 150GGC CCT TTT GGG CAT AAG CTC AAA GCT AAG TCT AAA GAC ATT ATC AAA 532Gly Pro Phe Gly His Lys Leu Lys Ala Lys Ser Lys Asp Ile Ile Lys
155 160 165GAA AAA ACC GTT CTT TTA GAG GGG ATT TTA GGC ATC GCT AAT GGG GAA 580Glu Lys Thr Val Leu Leu Glu Gly Ile Leu Gly Ile Ala Asn Gly Glu170 175 180 185AAC CCA AGG GAT TTA GAA AAC AAA CTC TTA AAC TAC ATC GCT CCC GGT 628Asn Pro Arg Asp Leu Glu Asn Lys Leu Leu Asn Tyr Ile Ala Pro Gly
190 195 200GAA CCT AAA AAA TCT CAA TTT GAG GGC TAAAGATGGC TAAGAAAAAC AMACCCA 682Glu Pro Lys Lys Ser Gln Phe Glu Gly
205 210CCGAATGCCC CGC 695
(2) Sequence 860 data:
(i) sequence characteristics:
(A) length: 210 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 860: met Thr Gly Thr His Ala Arg Tyr Val Lys Ala Ala Tyr Lys Glu Ile 151015 Lys Ile Val Phe Leu Asn Pro Lys Ile Asn Leu Asn Glu Thr Ile Lys
20 25 30Asn Leu Val Glu Leu Ala Thr Leu Ala Arg Lys Asp Gly Val Leu Ser
35 40 45Leu Glu Gly Arg Val Ala Gln Ile Glu Asp Asp Phe Thr Arg Asn Gly
50 55 60Leu Ser Met Ile Ile Asp Gly Lys Asp Leu Lys Ser Val Lys Glu Ser65 70 75 80Leu Glu Ile Ser Ile Glu Glu Met Glu Glu Tyr Tyr His Gly Ala Ala
85 90 95His Tyr Trp Glu Thr Ala Gly Glu Thr Ala Pro Thr Met Gly Leu Val
100 105 110Gly Ala Val Met Gly Leu Met Leu Ala Leu Gln Lys Leu Asp Asn Pro
115 120 125Ala Glu Met Ala Ala Gly Ile Ala Gly Ala Phe Thr Ala Thr Val Thr
130 135 140Gly Ile Met Cys Ser Tyr Ala Ile Phe Gly Pro Phe Gly His Lys Leu145 150 155 160Lys Ala Lys Ser Lys Asp Ile Ile Lys Glu Lys Thr Val Leu Leu Glu
165 170 175Gly Ile Leu Gly Ile Ala Asn Gly Glu Asn Pro Arg Asp Leu Glu Asn
180 185 190Lys Leu Leu Asn Tyr Ile Ala Pro Gly Glu Pro Lys Lys Ser Gln Phe
195 200 205Glu Gly
210
(2) Sequence 861 data:
(i) sequence characteristics:
(A) length: 810bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 13...783
(D) Other information:
(xi) Description of the sequence: sequence 861: TGAGGGCTAA AG ATG GCT AAG AAA AAC AMA CCC ACC GAA TGC CCC GCC GGT 51
Met Ala Lys Lys Asn Xaa Pro Thr Glu Cys Pro Ala Gly
1 5 10GAA AAA TGG GCG GTT CCT TAT GCG GAC TTT TTG TCG TTG TTG CTC GCG 99Glu Lys Trp Ala Val Pro Tyr Ala Asp Phe Leu Ser Leu Leu Leu Ala
15 20 25CTT TTT ATC GCT CTT TAT GCC ATT TCA GCG GTC AAC AAA TCC AAA GTG 147Leu Phe Ile Ala Leu Tyr Ala Ile Ser Ala Val Asn Lys Ser Lys Val30 35 40 45GAA GCC TTA AAA ACC GAA TTT ATT AAG ATT TTT AAT TAC GCT CCC AAG 195Glu Ala Leu Lys Thr Glu Phe Ile Lys Ile Phe Asn Tyr Ala Pro Lys
50 55 60CCA GAG GCG ATG CAG CCG GTT GTA GTG ATC CCG CCT GAT TCA GGG AAA 243Pro Glu Ala Met Gln Pro Val Val Val Ile Pro Pro Asp Ser Gly Lys
65 70 75GAA GAA GAA CAA ATG GCG AGC GAA AGC TCC AAA CCG GCT TCG CAA AAT 291Glu Glu Glu Gln Met Ala Ser Glu Ser Ser Lys Pro Ala Ser Gln Asn
80 85 90ACC GAA ACA AAA GCC ACT ATC GCT CGC AAA GGC GAA GGC AGT GTT TTA 339Thr Glu Thr Lys Ala Thr Ile Ala Arg Lys Gly Glu Gly Ser Val Leu
95 100 105GAG CAA ATT GAT CAA GGC TCT ATC TTA AAG CTC CCC TCT AAT TTG CTG 387Glu Gln Ile Asp Gln Gly Ser Ile Leu Lys Leu Pro Ser Asn Leu Leu110 115 120 125TTT GAA AAC GCT ACT TCA GAC GCT ATC AAT CAA GAC ATG ATG CTT TAT 435Phe Glu Asn Ala Thr Ser Asp Ala Ile Asn Gln Asp Met Met Leu Tyr
130 135 140ATT GAA CGG ATC GCT AAA ATC ATT CAA AAA CTC CCT AAA AGG GTG CAT 483Ile Glu Arg Ile Ala Lys Ile Ile Gln Lys Leu Pro Lys Arg Val His
145 150 155ATT AAT GTG AGA GGC TTT ACG GAT GAT ACG CCT TTA GTT AAA ACC CGT 531Ile Asn Val Arg Gly Phe Thr Asp Asp Thr Pro Leu Val Lys Thr Arg
160 165 170TTT AAA AGC CAT TAT GAA TTA GCC GCC AAT CGC GCT TAT AGG GTG ATG 579Phe Lys Ser His Tyr Glu Leu Ala Ala Asn Arg Ala Tyr Arg Val Met
175 180 185AAA GTC CTT ATA CAATAC GGC GTA AAT CCT AAC CAA TTG TCT TTT TCT 627Lys Val Leu Ile Gln Tyr Gly Val Asn Pro Asn Gln Leu Ser Phe Ser190 195 200 205TCT TAC GGC TCT ACC AAC CCT ATC GCG CCT AAC GAC TCC CTA GAG AAC 675Ser Tyr Gly Ser Thr Asn Pro Ile Ala Pro Asn Asp Ser Leu Glu Asn
210 215 220AGA ATG AAA AAC AAT CGT GTG GAA ATC TTT TTT TCA ACC GAT GCG AAC 723Arg Met Lys Asn Asn Arg Val Glu Ile Phe Phe Ser Thr Asp Ala Asn
225 230 235GAT TTG AGT AAA ATT CAT TCT ATT TTA GAT AAT GAG TTC AAT CCC CAC 771Asp Leu Ser Lys Ile His Ser Ile Leu Asp Asn Glu Phe Asn Pro His
240 245 250AAA CAG CAA GAA TGAATCGCAT GAATAAAAAT TATCTTT 810Lys Gln Gln Glu
255
(2) Sequence 862 data:
(i) sequence characteristics:
(A) length: 257 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 862: met Ala Lys Lys Asn Xaa Pro Thr Glu Cys Pro Ala Gly Glu Lys Trp 151015 Ala Val Pro Tyr Ala Asp Phe Leu Ser Leu Leu Leu Ala Leu Phe Ile
20 25 30Ala Leu Tyr Ala Ile Ser Ala Val Asn Lys Ser Lys Val Glu Ala Leu
35 40 45Lys Thr Glu Phe Ile Lys Ile Phe Asn Tyr Ala Pro Lys Pro Glu Ala
50 5560Met Gln Pro Val Val Val Ile Pro Pro Asp Ser Gly Lys Glu Glu Glu65 70 75 80Gln Met Ala Ser Glu Ser Ser Lys Pro Ala Ser Gln Asn Thr Glu Thr
85 90 95Lys Ala Thr Ile Ala Arg Lys Gly Glu Gly Ser Val Leu Glu Gln Ile
100 105 110Asp Gln Gly Ser Ile Leu Lys Leu Pro Ser Asn Leu Leu Phe Glu Asn
115 120 125Ala Thr Ser Asp Ala Ile Asn Gln Asp Met Met Leu Tyr Ile Glu Arg
130 135 140Ile Ala Lys Ile Ile Gln Lys Leu Pro Lys Arg Val His Ile Asn Val145 150 155 160Arg Gly Phe Thr Asp Asp Thr Pro Leu Val Lys Thr Arg Phe Lys Ser
165 170 175His Tyr Glu Leu Ala Ala Asn Arg Ala Tyr Arg Val Met Lys Val Leu
180 185 190Ile Gln Tyr Gly Val Asn Pro Asn Gln Leu Ser Phe Ser Ser Tyr Gly
195 200 205Ser Thr Asn Pro Ile Ala Pro Asn Asp Ser Leu Glu Asn Arg Met Lys
210 215 220Asn Asn Arg Val Glu Ile Phe Phe Ser Thr Asp Ala Asn Asp Leu Ser225 230 235 240Lys Ile His Ser Ile Leu Asp Asn Glu Phe Asn Pro His Lys Gln Gln
245 250 255Glu
(2) Sequence 863 data:
(i) sequence characteristics:
(A) length: 549bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...474
(D) Other information:
(xi) Description of the sequence: sequence 863: TGTTAAGATC AGTTT ATG GAA CAA AAT ATT TTC TCC TTA CTC ATT CAA AAA 51
Met Glu Gln Asn Ile Phe Ser Leu Leu Ile Gln Lys
1 5 10AAG TCT TAT AAA AAG CTT GAA ACC CTT TTG AAA CTC AAA AAG CTT AAG 99Lys Ser Tyr Lys Lys Leu Glu Thr Leu Leu Lys Leu Lys Lys Leu Lys
15 20 25GTT TTT ATG CCT TTA AGT TTA CAA GAA AAT TTG CTT TTT ATC TTC ATA 147Val Phe Met Pro Leu Ser Leu Gln Glu Asn Leu Leu Phe Ile Phe Ile
30 35 40AAA GAC TCT AAA TTG CTT TTT GCG TTT AAA GAC ATT TGG GCT TCT AAA 195Lys Asp Ser Lys Leu Leu Phe Ala Phe Lys Asp Ile Trp Ala Ser Lys45 50 55 60GAA TTT AAC CAA CGA TTC GCT AAA GAA ATC AGC CAT TTT TTA AAC ACG 243Glu Phe Asn Gln Arg Phe Ala Lys Glu Ile Ser His Phe Leu Asn Thr
65 70 75CAA GGG CAT GCT TAT GGG TTT GAC GGG TTG AAT GGG TTA GAA ATT TTA 291Gln Gly His Ala Tyr Gly Phe Asp Gly Leu Asn Gly Leu Glu Ile Leu
80 85 90GGT TAT GTG CCT AAA GAC GCG CTA AAA AAA TCC AAT TTT TAT GCC CCC 339Gly Tyr Val Pro Lys Asp Ala Leu Lys Lys Ser Asn Phe Tyr Ala Pro
95100 105ATT AAA AAA CAA GCC CGT TTT TTT CGC CCT AGT GCT TTA GGG TTG TTC 387Ile Lys Lys Gln Ala Arg Phe Phe Arg Pro Ser Ala Leu Gly Leu Phe
110 115 120CAT AAC CCC ATT AAA GAC GCT CGT TTG CAT GAA TGT TTT GAA AAA GCG 435His Asn Pro Ile Lys Asp Ala Arg Leu His Glu Cys Phe Glu Lys Ala125 130 135 140CGC GCT TTG ATC CAC TAC CAA CGA AGT TTT TTT GAG GAA TGAATGGCTG AT 486Arg Ala Leu Ile His Tyr Gln Arg Ser Phe Phe Glu Glu
145 150TTATTGTCCA GTTTAAAAAA CCTTCCTAAC AGCAGTGGCG TGTATCAATA TTTTGATAAA 546AAC 549
(2) Sequence 864:
(i) sequence characteristics:
(A) length: 153 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 864 data: met Glu Gln Asn Ile Phe Ser Leu Leu Ile Gln Lys Lys Ser Tyr Lys 151015 Lys Leu Glu Thr Leu Leu Lys Leu Lys Lys Leu Lys Val Phe Met Pro
20 25 30Leu Ser Leu Gln Glu Asn Leu Leu Phe Ile Phe Ile Lys Asp Ser Lys
35 40 45Leu Leu Phe Ala Phe Lys Asp Ile Trp Ala Ser Lys Glu Phe Asn Gln
50 55 60Arg Phe Ala Lys Glu Ile Ser His Phe Leu Asn Thr Gln Gly His Ala65 70 75 80Tyr Gly Phe Asp Gly Leu Asn Gly Leu Glu Ile LeuGly Tyr Val Pro
85 90 95Lys Asp Ala Leu Lys Lys Ser Asn Phe Tyr Ala Pro Ile Lys Lys Gln
100 105 110Ala Arg Phe Phe Arg Pro Ser Ala Leu Gly Leu Phe His Asn Pro Ile
115 120 125Lys Asp Ala Arg Leu His Glu Cys Phe Glu Lys Ala Arg Ala Leu Ile
130 135 140His Tyr Gln Arg Ser Phe Phe Glu Glu145 150
(2) Sequence 865 data:
(i) sequence characteristics:
(A) length: 352bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...318
(D) Other information:
(xi) Description of the sequence: sequence 865: AAG TGT TAC TTT TTT ATA ACT TTT TCA TAT TCT TAT GGG TAT GTT GTC 48Lys Cys Tyr Phe Phe Ile Thr Phe Ser Tyr Ser Tyr Gly Tyr Val Val 151015 ATT TTT TTA CCG GAG AAT TTT ATC TTG AGA AAC ATT TAT GTA GGG AAT 96Ile Phe Leu Pro Glu Asn Phe Ile Leu Arg Asn Ile Tyr Val Gly Asn
20 25 30TTG GTT TAT AGC GCT ACC AGT GAG CAA GTC AAG GAG CTT TTC AGT CAA 144Leu Val Tyr Ser Ala Thr Ser Glu Gln Val Lys Glu Leu Phe Ser Gln
35 40 45TTT GGC AAA GTT TTT AAT GTC AAG CTG ATT TAT GAC AGA GAA ACG AAG 192Phe Gly Lys Val Phe Asn Val Lys Leu Ile Tyr Asp Arg Glu Thr Lys
50 55 60AAA CCT AAA GGT TTT GGC TTT GTA GAA ATG CAA GAA GAG AGC GTT AGT 240Lys Pro Lys Gly Phe Gly Phe Val Glu Met Gln Glu Glu Ser Val Ser65 70 75 80GAA GCG ATC GCT AAA TTA GAC AAT ACG GAT TTT ATG GGC AGA ACG ATT 288Glu Ala Ile Ala Lys Leu Asp Asn Thr Asp Phe Met Gly Arg Thr Ile
85 90 95AGG GTA ACC GAA GCT AAT CCT AAA AAG TCT TAGTAACATT AGAAAATAAT TTT 341Arg Val Thr Glu Ala Asn Pro Lys Lys Ser
100 105CTAATGCGCT T 352
(2) Sequence 866 data:
(i) sequence characteristics:
(A) length: 106 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 866: lys Cys Tyr Phe Phe Ile Thr Phe Ser Tyr Ser Tyr Gly Tyr Val Val 151015 Ile Phe Leu Pro Glu Asn Phe Ile Leu Arg Asn Ile Tyr Val Gly Asn
20 25 30Leu Val Tyr Ser Ala Thr Ser Glu Gln Val Lys Glu Leu Phe Ser Gln
35 40 45Phe Gly Lys Val Phe Asn Val Lys Leu Ile Tyr Asp Arg Glu Thr Lys
50 55 60Lys Pro Lys Gly Phe Gly Phe Val Glu Met Gln Glu Glu Ser Val Ser65 70 7580Glu Ala Ile Ala Lys Leu Asp Asn Thr Asp Phe Met Gly Arg Thr Ile
85 90 95Arg Val Thr Glu Ala Asn Pro Lys Lys Ser
100 105
(2) Sequence 867 data:
(i) sequence characteristics:
(A) length: 1558bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...1473
(D) Other information:
(xi) Description of the sequence: sequence 867: TTAGATTTAA AATTAGATTA AGGATAGAAA ATG AGA ATT TTA CAA AGG GCT TTG 54
Met Arg Ile Leu Gln Arg Ala Leu
1 5ACT TTT GAA GAT GTG TTG ATG GTG CCT AGA AAG TCT AGC GTT TTA CCT 102Thr Phe Glu Asp Val Leu Met Val Pro Arg Lys Ser Ser Val Leu Pro
10 15 20AAA GAT GTG AGC TTA AAG TCT CGC TTA ACT AAA AAC ATT CGT TTG AAT 150Lys Asp Val Ser Leu Lys Ser Arg Leu Thr Lys Asn Ile Arg Leu Asn25 30 35 40ATC CCC TTT ATC AGT GCG GCT ATG GAT ACG GTT ACA GAG CAT AAA ACC 198Ile Pro Phe Ile Ser Ala Ala Met Asp Thr Val Thr Glu His Lys Thr
45 50 55GCT ATC GCT ATG GCG CGC CTT GGG GGT ATT GGC ATC GTG CAT AAA AAC 246Ala Ile Ala Met Ala Arg Leu Gly Gly Ile Gly Ile Val His Lys Asn
60 65 70ATG GAT ATT CAA ACG CAA GTT AAA GAA ATC ACT AAG GTT AAA AAA AGC 294Met Asp Ile Gln Thr Gln Val Lys Glu Ile Thr Lys Val Lys Lys Ser
75 80 85GAG AGC GGG GTG ATT AAT GAT CCT ATT TTT ATC CAT GCG CAC AGG ACG 342Glu Ser Gly Val Ile Asn Asp Pro Ile Phe Ile His Ala His Arg Thr
90 95 100CTA GCG GAC GCT AAA GTC ATA ACG GAT AAT TAC AAG ATT TCA GGC GTG 390Leu Ala Asp Ala Lys Val Ile Thr Asp Asn Tyr Lys Ile Ser Gly Val105 110 115 120CCT GTG GTA GAT GAT AAG GGG TTG TTG ATT GGG ATT TTA ACC AAC AGA 438Pro Val Val Asp Asp Lys Gly Leu Leu Ile Gly Ile Leu Thr Asn Arg
125 130 135GAT GTG CGC TTT GAA ACC GAT TTG AGT AAA AAA GTG GGC GAT GTG ATG 486Asp Val Arg Phe Glu Thr Asp Leu Ser Lys Lys Val Gly Asp Val Met
140 145 150ACT AAA ATG CCT TTA GTT ACC GCT CAT GTG GGT ATC AGT TTG GAT GAA 534Thr Lys Met Pro Leu Val Thr Ala His Val Gly Ile Ser Leu Asp Glu
155 160 165GCG AGC GAT TTG ATG CAC AAG CAT AAG ATT GAA AAA TTG CCC ATT GTG 582Ala Ser Asp Leu Met His Lys His Lys Ile Glu Lys Leu Pro Ile Val
170 175 180GAT AAA GAT AAT GTC TTA AAA GGC TTG ATC ACG ATC AAA GAT ATT CAA 630Asp Lys Asp Asn Val Leu Lys Gly Leu Ile Thr Ile Lys Asp Ile Gln185 190 195 200AAA CGC ATT GAA TAC CCT GAG GCC AAT AAA GAT GAT TTT GGG AGG TTG 678Lys Arg Ile Glu Tyr Pro Glu Ala Asn Lys Asp Asp Phe Gly Arg Leu
205 210 215AGA GTG GGG GCG GCT ATT GGA GTG GGG CAG TTG GAT AGG GCT GAG ATG 726Arg Val Gly Ala Ala Ile Gly Val Gly Gln Leu Asp Arg Ala Glu Met
220 225 230TTA GTT AAA GCG GGG GTG GAT GCA CTG GTG CTA GAC AGC GCA CAT GGG 774Leu Val Lys Ala Gly Val Asp Ala Leu Val Leu Asp Ser Ala His Gly
235 240 245CAT TCA GCC AAT ATC TTA CAC ACT TTA GAA GAG ATT AAA AAA AGC TTG 822His Ser Ala Asn Ile Leu His Thr Leu Glu Glu Ile Lys Lys Ser Leu
250 255 260GTA GTG GAT GTG ATT GTG GGG AAT GTG GTT ACT AAA GAA GCC ACA AGC 870Val Val Asp Val Ile Val Gly Asn Val Val Thr Lys Glu Ala Thr Ser265 270 275 280GAT TTG ATT AGC GCG GGA GCA GAC GCT ATT AAA GTG GGT ATT GGG CCA 918Asp Leu Ile Ser Ala Gly Ala Asp Ala Ile Lys Val Gly Ile Gly Pro
285 290 295GGA AGC ATT TGC ACC ACT AGG ATT GTG GCT GGG GTG GGA ATG CCC CAA 966Gly Ser Ile Cys Thr Thr Arg Ile Val Ala Gly Val Gly Met Pro Gln
300 305 310GTG AGC GCG ATT GAT AAT TGC GTA GAA GTG GCG TCT AAA TTT GAT ATT 1014Val Ser Ala Ile Asp Asn Cys Val Glu Val Ala Ser Lys Phe Asp Ile
315 320 325CCT GTG ATT GCA GAT GGA GGG ATC CGC TAT TCA GGC GAT GTG GCT AAG 1062Pro Val Ile Ala Asp Gly Gly Ile Arg Tyr Ser Gly Asp Val Ala Lys
330 335 340GCT TTG GCT TTG GGG GCA TCA AGC GTG ATG ATA GGC TCT TTA CTC GCT 1110Ala Leu Ala Leu Gly Ala Ser Ser Val Met Ile Gly Ser Leu Leu Ala345 350 355 360GGC ACA GAA GAA TCT CCT GGG GAT TTT ATG ATC TAT CAA GGG AGG CAA 1158Gly Thr Glu Glu Ser Pro Gly Asp Phe Met Ile Tyr Gln Gly Arg Gln
365 370 375TAT AAA AGC TAT AGG GGC ATG GGC AGC ATT GGG GCT ATG ACT AAA GGG 1206Tyr Lys Ser Tyr Arg Gly Met Gly Ser Ile Gly Ala Met Thr Lys Gly
380 385 390AGC TCT GAT AGG TAT TTT CAA GAG GGC GTA GCG AGT GAA AAG TTA GTC 1254Ser Ser Asp Arg Tyr Phe Gln Glu Gly Val Ala Ser Glu Lys Leu Val
395 400 405CCA GAA GGC ATT GAA GGG CGT GTG CCT TAT CGT GGT AAG GTT TCG GAT 1302Pro Glu Gly Ile Glu Gly Arg Val Pro Tyr Arg Gly Lys Val Ser Asp
410 415 420ATG ATT TTC CAA TTA GTA GGG GGC GTG CGC TCT TCT ATG GGG TAT CAG 1350Met Ile Phe Gln Leu Val Gly Gly Val Arg Ser Ser Met Gly Tyr Gln425 430 435 440GGG GCG AAA AAT ATT TTG GAA TTG TAT CAA AAC GCT GAA TTT GTA GAA 1398Gly Ala Lys Asn Ile Leu Glu Leu Tyr Gln Asn Ala Glu Phe Val Glu
445 450 455ATC ACT AGC GCG GGG TTA AAA GAA AGC CAT GTG CAT GGC GTG GAT ATT 1446Ile Thr Ser Ala Gly Leu Lys Glu Ser His Val His Gly Val Asp Ile
460 465 470ACT AAA GAA GCC CCT AAT TAT TAT GGG TGAATTGTAA AAGAAAACAA GACAAAT 1500Thr Lys Glu Ala Pro Asn Tyr Tyr Gly
475 480CGTTAAAAAA CTCGTTAAAA AGCTTGGTTT AATGAGTTTT TAAAACTTAA TTGCTACA 1558
(2) Sequence 868 data:
(i) sequence characteristics:
(A) length: 481 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 868: met Arg Ile Leu Gln Arg Ala Leu Thr Phe Glu Asp Val Leu Met Val 151015 Pro Arg Lys Ser Ser Val Leu Pro Lys Asp Val Ser Leu Lys Ser Arg
20 25 30Leu Thr Lys Asn Ile Arg Leu Asn Ile Pro Phe Ile Ser Ala Ala Met
35 40 45Asp Thr Val Thr Glu His Lys Thr Ala Ile Ala Met Ala Arg Leu Gly
50 55 60Gly Ile Gly Ile Val His Lys Asn Met Asp Ile Gln Thr Gln Val Lys65 70 75 80Glu Ile Thr Lys Val Lys Lys Ser Glu Ser Gly Val Ile Asn Asp Pro
85 90 95Ile Phe Ile His Ala His Arg Thr Leu Ala Asp Ala Lys Val Ile Thr
100 105 110Asp Asn Tyr Lys Ile Ser Gly Val Pro Val Val Asp Asp Lys Gly Leu
115 120 125Leu Ile Gly Ile Leu Thr Asn Arg Asp Val Arg Phe Glu Thr Asp Leu
130 135 140Ser Lys Lys Val Gly Asp Val Met Thr Lys Met Pro Leu Val Thr Ala145 150 155 160His Val Gly Ile Ser Leu Asp Glu Ala Ser Asp Leu Met His Lys His
165 170 175Lys Ile Glu Lys Leu Pro Ile Val Asp Lys Asp Asn Val Leu Lys Gly
180 185 190Leu Ile Thr Ile Lys Asp Ile Gln Lys Arg Ile Glu Tyr Pro Glu Ala
195 200 205Asn Lys Asp Asp Phe Gly Arg Leu Arg Val Gly Ala Ala Ile Gly Val
210 215 220Gly Gln Leu Asp Arg Ala Glu Met Leu Val Lys Ala Gly Val Asp Ala225 230 235 240Leu Val Leu Asp Ser Ala His Gly His Ser Ala Asn Ile Leu His Thr
245 250 255Leu Glu Glu Ile Lys Lys Ser Leu Val Val Asp Val Ile Val Gly Asn
260 265 270Val Val Thr Lys Glu Ala Thr Ser Asp Leu Ile Ser Ala Gly Ala Asp
275 280 285Ala Ile Lys Val Gly Ile Gly Pro Gly Ser Ile Cys Thr Thr Arg Ile
290 295 300Val Ala Gly Val Gly Met Pro Gln Val Ser Ala Ile Asp Asn Cys Val305 310 315 320Glu Val Ala Ser Lys Phe Asp Ile Pro Val Ile Ala Asp Gly Gly Ile
325 330 335Arg Tyr Ser Gly Asp Val Ala Lys Ala Leu Ala Leu Gly Ala Ser Ser
340 345 350Val Met Ile Gly Ser Leu Leu Ala Gly Thr Glu Glu Ser Pro Gly Asp
355 360 365Phe Met Ile Tyr Gln Gly Arg Gln Tyr Lys Ser Tyr Arg Gly Met Gly
370 375 380Ser Ile Gly Ala Met Thr Lys Gly Ser Ser Asp Arg Tyr Phe Gln Glu385 390 395 400Gly Val Ala Ser Glu Lys Leu Val Pro Glu Gly Ile Glu Gly Arg Val
405 410 415Pro Tyr Arg Gly Lys Val Ser Asp Met Ile Phe Gln Leu Val Gly Gly
420 425 430Val Arg Ser Ser Met Gly Tyr Gln Gly Ala Lys Asn Ile Leu Glu Leu
435 440 445Tyr Gln Asn Ala Glu Phe Val Glu Ile Thr Ser Ala Gly Leu Lys Glu
450 455 460Ser His Val His Gly Val Asp Ile Thr Lys Glu Ala Pro Asn Tyr Tyr465 470 475 480Gly
(2) Sequence 869 data:
(i) sequence characteristics:
(A) length: 919bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 58...876
(D) Other information:
(xi) Description of the sequence: sequence 869: TAATGAAAAA TAGTTCATGA ACGCTTTTGC ATTAAGGCTC AAAAAAAGCG CCGTTTA ATG 60
Met
1GAT TTT TGT AAA ATA AAA GAA ATT TTA AGG AGG CTT GTG GTG TTG AAA 108Asp Phe Cys Lys Ile Lys Glu Ile Leu Arg Arg Leu Val Val Leu Lys
5 10 15GAA TTA CGC CAA AAA CGC CCT TTA GTG CAT AAT ATC ACC AAT TAT GTG 156Glu Leu Arg Gln Lys Arg Pro Leu Val His Asn Ile Thr Asn Tyr Val
20 25 30GCG GCG CAA TTT GTG GCTAAT GGT TTG TTA GCT TTA GGG GCA TCG CCT 204Ala Ala Gln Phe Val Ala Asn Gly Leu Leu Ala Leu Gly Ala Ser Pro
35 40 45TTA ATG AGC GAT GCG ATT GAT GAA ATG CGA GAT TTA GCG AAA ATT TCT 252Leu Met Ser Asp Ala Ile Asp Glu Met Arg Asp Leu Ala Lys Ile Ser50 55 60 65GAC GCG CTC GCT ATC AAT ATT GGC ACC CTT AAT GAT CGC GCT ATT TTA 300Asp Ala Leu Ala Ile Asn Ile Gly Thr Leu Asn Asp Arg Ala Ile Leu
70 75 80TGC GCT AAA GAG GCT ATC AAG CAT TAC AAG GCT TTG AAC AAA CCC ATT 348Cys Ala Lys Glu Ala Ile Lys His Tyr Lys Ala Leu Asn Lys Pro Ile
85 90 95GTG TTA GAT CCT GTG GGG TGT TCA GCG AGC GCT TTG CGT CAT GAC ACC 396Val Leu Asp Pro Val Gly Cys Ser Ala Ser Ala Leu Arg His Asp Thr
100 105 110AGT TTA GAG CTT TTG AAA AGT GGT GGG ATT AGC GCG CTT AGG GGT AAT 444Ser Leu Glu Leu Leu Lys Ser Gly Gly Ile Ser Ala Leu Arg Gly Asn
115 120 125GCT GCA GAA TTA GGC TCT TTA GTG GGG ATT TCT TGC GAA AGT AAG GGG 492Ala Ala Glu Leu Gly Ser Leu Val Gly Ile Ser Cys Glu Ser Lys Gly130 135 140 145CTA GAC TCT AAT GAT GCC GCC ACG CCT GTA GAA ATA ATC AAA TTA GCG 540Leu Asp Ser Asn Asp Ala Ala Thr Pro Val Glu Ile Ile Lys Leu Ala
150 155 160GCT CAA AAA TAT TCT GTG ATA GCG GTA ATG ACG GGT AAA ACA GAT TAC 588Ala Gln Lys Tyr Ser Val Ile Ala Val Met Thr Gly Lys Thr Asp Tyr
165 170 175GTG AGC GAT GGG AAA AAG GTT TTG AGT ATT ACT GGG GGG AGC GAG TAT 636Val Ser Asp Gly Lys Lys Val Leu Ser Ile Thr Gly Gly Ser Glu Tyr
180 185 190TTA GCG CTC ATT ACT GGG GCT GGG TGT TTG CAT GCC GCA GCA TGC GCG 684Leu Ala Leu Ile Thr Gly Ala Gly Cys Leu His Ala Ala Ala Cys Ala
195 200 205AGC TTT TTA AGT TTG AAA AAA GAC CCC TTA GAT TCT ATG GCG CAA CTT 732Ser Phe Leu Ser Leu Lys Lys Asp Pro Leu Asp Ser Met Ala Gln Leu210 215 220 225TGC GCG CTC TAT AAA CAA GCC GCT TTT AAC GCG CAA AAA AAG GTG TTG 780Cys Ala Leu Tyr Lys Gln Ala Ala Phe Asn Ala Gln Lys Lys Val Leu
230 235 240GAA AAT AAC GGC TCT AAT GGT TCG TTC TTG TTT TAT TTT TTA GAT GCT 828Glu Asn Asn Gly Ser Asn Gly Ser Phe Leu Phe Tyr Phe Leu Asp Ala
245 250 255CTA AGC TTG CCC ATA GAG TTA GAA AAC AGC CTT ATT AAG GAA GAG TGG T 877Leu Ser Leu Pro Ile Glu Leu Glu Asn Ser Leu Ile Lys Glu Glu Trp
260 265 270GAAAATTTAC CCGCAAGTTT TAAGCATTGC TGGCAGCGAT AG 919
(2) Sequence 870 data:
(i) sequence characteristics:
(A) length: 273 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 870: met Asp Phe Cys Lys Ile Lys Glu Ile Leu Arg Arg Leu Val Val Leu 151015 Lys Glu Leu Arg Gln Lys Arg Pro Leu Val His Asn Ile Thr Asn Tyr
20 25 30Val Ala AlaGln Phe Val Ala Asn Gly Leu Leu Ala Leu Gly Ala Ser
35 40 45Pro Leu Met Ser Asp Ala Ile Asp Glu Met Arg Asp Leu Ala Lys Ile
50 55 60Ser Asp Ala Leu Ala Ile Asn Ile Gly Thr Leu Asn Asp Arg Ala Ile65 70 75 80Leu Cys Ala Lys Glu Ala Ile Lys His Tyr Lys Ala Leu Asn Lys Pro
85 90 95Ile Val Leu Asp Pro Val Gly Cys Ser Ala Ser Ala Leu Arg His Asp
100 105 110Thr Ser Leu Glu Leu Leu Lys Ser Gly Gly Ile Ser Ala Leu Arg Gly
115 120 125Asn Ala Ala Glu Leu Gly Ser Leu Val Gly Ile Ser Cys Glu Ser Lys
130 135 140Gly Leu Asp Ser Asn Asp Ala Ala Thr Pro Val Glu Ile Ile Lys Leu145 150 155 160Ala Ala Gln Lys Tyr Ser Val Ile Ala Val Met Thr Gly Lys Thr Asp
165 170 175Tyr Val Ser Asp Gly Lys Lys Val Leu Ser Ile Thr Gly Gly Ser Glu
180 185 190Tyr Leu Ala Leu Ile Thr Gly Ala Gly Cys Leu His Ala Ala Ala Cys
195 200 205Ala Ser Phe Leu Ser Leu Lys Lys Asp Pro Leu Asp Ser Met Ala Gln
210 215 220Leu Cys Ala Leu Tyr Lys Gln Ala Ala Phe Asn Ala Gln Lys Lys Val225 230 235 240Leu Glu Asn Asn Gly Ser Asn Gly Ser Phe Leu Phe Tyr Phe Leu Asp
245 250 255Ala Leu SerLeu Pro Ile Glu Leu Glu Asn Ser Leu Ile Lys Glu Glu
260 265 270Trp
(2) Sequence 871 data:
(i) sequence characteristics:
(A) length: 1010bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 78...971
(D) Other information:
(xi) Description of the sequence: sequence 871: ATCCAAATAA TTGGGCGATT AAAGAGGGAA TTTATTCAAT CAAACCAAAT AAAAAAATAG 60TATTTCCAAG ATTTTTA ATG TTT TGC TTT GAA AAT TTG AAT ATT CAA AAT 110
Met Phe Cys Phe Glu Asn Leu Asn Ile Gln Asn
1 5 10GMT ATA AAA AGT AAA AGT TTT GGA GGA ATA GTT AAA AGT ATA TCA ATG 158Xaa Ile Lys Ser Lys Ser Phe Gly Gly Ile Val Lys Ser Ile Ser Met
15 20 25AAC GAT TTA CAA CAA ATA ACC ATC CCC ATC CCA CCC CTA GAG ATC CAA 206Asn Asp Leu Gln Gln Ile Thr Ile Pro Ile Pro Pro Leu Glu Ile Gln
30 35 40CAA GAG ATC GTT AAG ATT TTG GAC GCT TTC ACA GAA TTA AAC ACA GAA 254Gln Glu Ile Val Lys Ile Leu Asp Ala Phe Thr Glu Leu Asn Thr Glu
45 50 55TTA AAC ACA GAA TTA AAA GCG CGC AAA AAG CAA TAT GAG TAT TAC CAA 302Leu Asn Thr Glu Leu Lys Ala Arg LysLys Gln Tyr Glu Tyr Tyr Gln60 65 70 75AAC ATG CTT TTA GAC TTT AAC GAT ATT AAT CAA AAC CAC AAA GAC GCC 350Asn Met Leu Leu Asp Phe Asn Asp Ile Asn Gln Asn His Lys Asp Ala
80 85 90AAA ATA AAA ACC TAC CCT AAA CGC TTG AAA ACC TTA CTC CAC ACT TTA 398Lys Ile Lys Thr Tyr Pro Lys Arg Leu Lys Thr Leu Leu His Thr Leu
95 100 105GCG CCT AAG GGG GTG GAG TTT AGG AAA TTG GGG GAG GTG TGT GAA AGC 446Ala Pro Lys Gly Val Glu Phe Arg Lys Leu Gly Glu Val Cys Glu Ser
110 115 120ACA AAT AAA AAA ACA CTC AAA ATA AGC GAA GTA AGT GAA GTA AAA AAT 494Thr Asn Lys Lys Thr Leu Lys Ile Ser Glu Val Ser Glu Val Lys Asn
125 130 135AAG GGA ATG TAT CCA GTG ATA AAT TCA GGG AGG GAT TTG TAT GGT TAT 542Lys Gly Met Tyr Pro Val Ile Asn Ser Gly Arg Asp Leu Tyr Gly Tyr140 145 150 155TAC CAT GAT TTT AAC AAT GAr GGA GAA AAT ATA ACT ATT GCA TCT AGG 590Tyr His Asp Phe Asn Asn Asp Gly Glu Asn Ile Thr Ile Ala Ser Arg
160 165 170GGA GAA TAT GCA GGA TTT ATA AAC TAT TTC AAT GAA AAA TTT TTT GCA 638Gly Glu Tyr Ala Gly Phe Ile Asn Tyr Phe Asn Glu Lys Phe Phe Ala
175 180 185GGG GGT CTA TGT TAT CCC TAT AAA GTT AAA GAC ACT AAC GAG CTT TTA 686Gly Gly Leu Cys Tyr Pro Tyr Lys Val Lys Asp Thr Asn Glu Leu Leu
190 195 200ACA AAA TTT TTA TAC TTT TAT CTC AAA ACT AAT GAA ATC CAA ATT ATG 734Thr Lys Phe Leu Tyr Phe Tyr Leu Lys Thr Asn Glu Ile Gln Ile Met
205210 215GAG AAC CTT GTT TTT CGT GGC AGT ATC CCC GCA CTC AAT AAA GCA GAT 782Glu Asn Leu Val Phe Arg Gly Ser Ile Pro Ala Leu Asn Lys Ala Asp220 225 230 235ATT GAA ACT TTA ACA ATC CCC ATC CCA CCT CTA GAG ATC CAA CAA GAG 830Ile Glu Thr Leu Thr Ile Pro Ile Pro Pro Leu Glu Ile Gln Gln Glu
240 245 250ATC GTT AAG ATT TTG GAT CAA TTT TCA GCC CTA ACC ACC GAT TTA TTA 878Ile Val Lys Ile Leu Asp Gln Phe Ser Ala Leu Thr Thr Asp Leu Leu
255 260 265GCC GGT ATC CCC GCT GAA ATA AAA GCC CGA AAA AAG CAA TAC GAA TAT 926Ala Gly Ile Pro Ala Glu Ile Lys Ala Arg Lys Lys Gln Tyr Glu Tyr
270 275 280TAC CGA GAA AAA CTA CTG ACC TTC AAA CCT CTC CAA AAC AAG GAA TAACA 976Tyr Arg Glu Lys Leu Leu Thr Phe Lys Pro Leu Gln Asn Lys Glu
285 290 295TGAGTTACGA AACGATCGCA GAAAGCAATG AAAG 1010
(2) Sequence 872 data:
(i) sequence characteristics:
(A) length: 298 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 872: met Phe Cys Phe Glu Asn Leu Asn Ile Gln Asn Xaa Ile Lys Ser Lys 151015 Ser Phe Gly Gly Ile Val Lys Ser Ile Ser Met Asn Asp Leu Gln Gln
20 25 30Ile Thr Ile Pro Ile Pro Pro Leu Glu Ile Gln Gln Glu Ile Val Lys
35 40 45Ile Leu Asp Ala Phe Thr Glu Leu Asn Thr Glu Leu Asn Thr Glu Leu
50 55 60Lys Ala Arg Lys Lys Gln Tyr Glu Tyr Tyr Gln Asn Met Leu Leu Asp65 70 75 80Phe Asn Asp Ile Asn Gln Asn His Lys Asp Ala Lys Ile Lys Thr Tyr
85 90 95Pro Lys Arg Leu Lys Thr Leu Leu His Thr Leu Ala Pro Lys Gly Val
100 105 110Glu Phe Arg Lys Leu Gly Glu Val Cys Glu Ser Thr Asn Lys Lys Thr
115 120 125Leu Lys Ile Ser Glu Val Ser Glu Val Lys Asn Lys Gly Met Tyr Pro
130 135 140Val Ile Asn Ser Gly Arg Asp Leu Tyr Gly Tyr Tyr His Asp Phe Asn145 150 155 160Asn Asp Gly Glu Asn Ile Thr Ile Ala Ser Arg Gly Glu Tyr Ala Gly
165 170 175Phe Ile Asn Tyr Phe Asn Glu Lys Phe Phe Ala Gly Gly Leu Cys Tyr
180 185 190Pro Tyr Lys Val Lys Asp Thr Asn Glu Leu Leu Thr Lys Phe Leu Tyr
195 200 205Phe Tyr Leu Lys Thr Asn Glu Ile Gln Ile Met Glu Asn Leu Val Phe
210 215 220Arg Gly Ser Ile Pro Ala Leu Asn Lys Ala Asp Ile Glu Thr Leu Thr225 230 235 240Ile Pro Ile Pro Pro Leu Glu Ile Gln Gln Glu Ile Val Lys Ile Leu
245 250 255Asp Gln Phe Ser Ala Leu Thr Thr Asp Leu Leu Ala Gly Ile Pro Ala
260 265 270Glu Ile Lys Ala Arg Lys Lys Gln Tyr Glu Tyr Tyr Arg Glu Lys Leu
275 280 285Leu Thr Phe Lys Pro Leu Gln Asn Lys Glu
290 295
(2) Sequence 873 data:
(i) sequence characteristics:
(A) length: 1305bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 42...1253
(D) Other information:
(xi) Description of the sequence: sequence 873: GATTAGGGGA GTTAGAAACC ATTTGCGTGG AAGAAGATCC C ATG TAT GAA TGC GAA 56
Met Tyr Glu Cys Glu
1 5GTG GCG ATT GAA AAA ATC CTA GAA GAT TTA GGC ATT CCT AGC TCT AAA 104Val Ala Ile Glu Lys Ile Leu Glu Asp Leu Gly Ile Pro Ser Ser Lys
10 15 20CAC AAC GAT TTG ATG AAA ACC CTG CCA AGC AGC GAT AAA TTT AAA ATC 152His Asn Asp Leu Met Lys Thr Leu Pro Ser Ser Asp Lys Phe Lys Ile
25 30 35CTT CTC GCT CAA GTC TTG TTC CCT AAA CCG GAT ATT TTG CTT TTA GAT 200Leu Leu Ala Gln Val Leu Phe Pro Lys Pro Asp Ile Leu Leu Leu Asp
40 4550GAG CCG ACC AAC AAC CTG GAT TTA AAC GCC ATT GAA TGG CTA GAA AAC 248Glu Pro Thr Asn Asn Leu Asp Leu Asn Ala Ile Glu Trp Leu Glu Asn
55 60 65AAC CTC AAA CGC CAT GAA GGC ACG ATG GTC GTC ATT AGC CAT GAC AGG 296Asn Leu Lys Arg His Glu Gly Thr Met Val Val Ile Ser His Asp Arg70 75 80 85CAT TTT TTA AAT GCG GTA TGC ACG CAT ATT TTG GAT TTG GAT TTC CAC 344His Phe Leu Asn Ala Val Cys Thr His Ile Leu Asp Leu Asp Phe His
90 95 100AGC GTG CGC GAA TTT AGC GGG AAT TAT GAC GAT TGG TAT ATC GCT TCC 392Ser Val Arg Glu Phe Ser Gly Asn Tyr Asp Asp Trp Tyr Ile Ala Ser
105 110 115ACT CTG ATC GCT AAA CAG CAA GAG GCC GAA CGC AAT AAA AAA CTC AAA 440Thr Leu Ile Ala Lys Gln Gln Glu Ala Glu Arg Asn Lys Lys Leu Lys
120 125 130GAA AAA GAA GAG CTA GAA AAA TTC ATC GCG CGC TTT ARN NNN NAC GCT 488Glu Lys Glu Glu Leu Glu Lys Phe Ile Ala Arg Phe Xaa Xaa Xaa Ala
135 140 145TCT AAA GCC AAG CAA GCC ACC AGC CGC CAA AAA CAA CTG GAT AAA TTA 536Ser Lys Ala Lys Gln Ala Thr Ser Arg Gln Lys Gln Leu Asp Lys Leu150 155 160 165GAC ATT CAA AGT TTA GCG GTA TCT AGC AGG AGG GAT CCT AGC ATT ATT 584Asp Ile Gln Ser Leu Ala Val Ser Ser Arg Arg Asp Pro Ser Ile Ile
170 175 180TTT AAA CCC AAA CGC ACC ATT GGT AAT GAA GCC TTA GAG TGC GAA AAC 632Phe Lys Pro Lys Arg Thr Ile Gly Asn Glu Ala Leu Glu Cys Glu Asn
185 190 195ATC TCT AAA AGT TAT GAC GAC CAA ATC GTT TTA AAT CAA GTG AGC TTG680Ile Ser Lys Ser Tyr Asp Asp Gln Ile Val Leu Asn Gln Val Ser Leu
200 205 210AAA GTG ATG CCT AAA GAC AAG ATC GCC CTC ATA GGG CCA AAC GGC GTG 728Lys Val Met Pro Lys Asp Lys Ile Ala Leu Ile Gly Pro Asn Gly Val
215 220 225GGT AAA TCC ACG CTT TGT AAA ATT CTA GTA GAA GAA TTA AAG CCG GAT 776Gly Lys Ser Thr Leu Cys Lys Ile Leu Val Glu Glu Leu Lys Pro Asp230 235 240 245AAG GGC GTG GTG AAA TGG GGG GCG ACG GTT TCA AAA GGC TAT TTC CCT 824Lys Gly Val Val Lys Trp Gly Ala Thr Val Ser Lys Gly Tyr Phe Pro
250 255 260CAA AAC GTG AGC GAA GAA ATT AGC GGG GAA GAG ACC TTG TAT CAA TGG 872Gln Asn Val Ser Glu Glu Ile Ser Gly Glu Glu Thr Leu Tyr Gln Trp
265 270 275CTC TTT AAC TTC AAT AAA AAG ATT GAA AGC GCT GAG GTT AGG AAC GCT 920Leu Phe Asn Phe Asn Lys Lys Ile Glu Ser Ala Glu Val Arg Asn Ala
280 285 290TTA GGG AGG ATG CTG TTT AAT GGC GAA GAG CAA GAA AAA TGC GTG AAC 968Leu Gly Arg Met Leu Phe Asn Gly Glu Glu Gln Glu Lys Cys Val Asn
295 300 305GCT TTA AGT GGG GGC GAA AAA CAC CGA ATG GTT TTA TCC AAG CTC ATG 1016Ala Leu Ser Gly Gly Glu Lys His Arg Met Val Leu Ser Lys Leu Met310 315 320 325CTA GAG GGG GGG AAT TTT TTA GTC TTA GAT GAG CCA ACC AAC CAT TTG 1064Leu Glu Gly Gly Asn Phe Leu Val Leu Asp Glu Pro Thr Asn His Leu
330 335 340GAT TTA GAA GCG ATT ATC GCT TTA GGC GAA GCG CTC TTT AAA TTT GAT 1112Asp Leu Glu Ala Ile Ile Ala Leu Gly Glu Ala Leu Phe Lys Phe Asp
345 350 355GGG GCG CTG ATT TGC GTA AGC CAT GAC AGA GAG CTC ATT GAT GCG TAT 1160Gly Ala Leu Ile Cys Val Ser His Asp Arg Glu Leu Ile Asp Ala Tyr
360 365 370GCT AAT AGG ATC ATT GAA TTA GTC CCA AGC CCT AAA GGC GCT TCA ATC 1208Ala Asn Arg Ile Ile Glu Leu Val Pro Ser Pro Lys Gly Ala Ser Ile
375 380 385ATT GAT TTT AAA GGC AGT TAT GAA GAG TAT TTG GCG AGC AAA AAA TGAAA 1258Ile Asp Phe Lys Gly Ser Tyr Glu Glu Tyr Leu Ala Ser Lys Lys390 395 400CCGCAAGACA TTGAAATCGT TCAAAGCGTT TTAGAGATTA CAGGACC 1305
(2) Sequence 874 data:
(i) sequence characteristics:
(A) length: 404 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 874: met Tyr Glu Cys Glu Val Ala Ile Glu Lys Ile Leu Glu Asp Leu Gly 151015 Ile Pro Ser Ser Lys His Asn Asp Leu Met Lys Thr Leu Pro Ser Ser
20 25 30Asp Lys Phe Lys Ile Leu Leu Ala Gln Val Leu Phe Pro Lys Pro Asp
35 40 45Ile Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Leu Asn Ala Ile
50 55 60Glu Trp Leu Glu Asn Asn Leu Lys Arg His Glu Gly Thr Met Val Val65 70 75 80Ile Ser His Asp Arg His Phe Leu Asn Ala Val Cys Thr His Ile Leu
85 90 95Asp Leu Asp Phe His Ser Val Arg Glu Phe Ser Gly Asn Tyr Asp Asp
100 105 110Trp Tyr Ile Ala Ser Thr Leu Ile Ala Lys Gln Gln Glu Ala Glu Arg
115 120 125Asn Lys Lys Leu Lys Glu Lys Glu Glu Leu Glu Lys Phe Ile Ala Arg
130 135 140Phe Xaa Xaa Xaa Ala Ser Lys Ala Lys Gln Ala Thr Ser Arg Gln Lys145 150 155 160Gln Leu Asp Lys Leu Asp Ile Gln Ser Leu Ala Val Ser Ser Arg Arg
165 170 175Asp Pro Ser Ile Ile Phe Lys Pro Lys Arg Thr Ile Gly Asn Glu Ala
180 185 190Leu Glu Cys Glu Asn Ile Ser Lys Ser Tyr Asp Asp Gln Ile Val Leu
195 200 205Asn Gln Val Ser Leu Lys Val Met Pro Lys Asp Lys Ile Ala Leu Ile
210 215 220Gly Pro Asn Gly Val Gly Lys Ser Thr Leu Cys Lys Ile Leu Val Glu225 230 235 240Glu Leu Lys Pro Asp Lys Gly Val Val Lys Trp Gly Ala Thr Val Ser
245 250 255Lys Gly Tyr Phe Pro Gln Asn Val Ser Glu Glu Ile Ser Gly Glu Glu
260 265 270Thr Leu Tyr Gln Trp Leu Phe Asn Phe Asn Lys Lys Ile Glu Ser Ala
275 280 285Glu Val Arg Asn Ala Leu Gly Arg Met Leu Phe Asn Gly Glu Glu Gln
290 295 300Glu Lys Cys Val Asn Ala Leu Ser Gly Gly Glu Lys His Arg Met Val305 310 315 320Leu Ser Lys Leu Met Leu Glu Gly Gly Asn Phe Leu Val Leu Asp Glu
325 330 335Pro Thr Asn His Leu Asp Leu Glu Ala Ile Ile Ala Leu Gly Glu Ala
340 345 350Leu Phe Lys Phe Asp Gly Ala Leu Ile Cys Val Ser His Asp Arg Glu
355 360 365Leu Ile Asp Ala Tyr Ala Asn Arg Ile Ile Glu Leu Val Pro Ser Pro
370 375 380Lys Gly Ala Ser Ile Ile Asp Phe Lys Gly Ser Tyr Glu Glu Tyr Leu385 390 395 400Ala Ser Lys Lys
(2) Sequence 875 data:
(i) sequence characteristics:
(A) length: 801bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...756
(D) Other information:
(xi) Description of the sequence: sequence 875: AAAAGCAGGG ATACTAGA ATG CAA ATG ATG CAC AAT TTG AGT TTT TTG GGC 51
Met Gln Met Met His Asn Leu Ser Phe Leu Gly
1 5 10ATG TTT TTA GCC GCT TTG AGC ATG TCT TTA GGG CAT TGT GTG GGC ATG 99Met Phe Leu Ala Ala Leu Ser Met Ser Leu Gly His Cys Val Gly Met
15 20 25TGT GGG GGG ATT GTG AGC GCG TTC AGT CAA ATA AGA TTT TCT AAA GTT 147Cys Gly Gly Ile Val Ser Ala Phe Ser Gln Ile Arg Phe Ser Lys Val
30 35 40ACA AGC TTT TCT TAC CAG CTC ACT TGC CAT GCC CTT TAT AAT GTA GGG 195Thr Ser Phe Ser Tyr Gln Leu Thr Cys His Ala Leu Tyr Asn Val Gly
45 50 55AGG ATC AGC ACT TAC ATG CTT TTA GGG GCT ATA GCG GCA AGT TTG GGG 243Arg Ile Ser Thr Tyr Met Leu Leu Gly Ala Ile Ala Ala Ser Leu Gly60 65 70 75CAT AGT CTT AGC GTG AGC ATG GGT TTT AGG GGT GTT TTA TTC ATT AGC 291His Ser Leu Ser Val Ser Met Gly Phe Arg Gly Val Leu Phe Ile Ser
80 85 90ATG GGG ATT ATT TTG ATC TGT TTA GCG TTG CTA GGG GCA AGA ATG GAA 339Met Gly Ile Ile Leu Ile Cys Leu Ala Leu Leu Gly Ala Arg Met Glu
95 100 105AAA TTA AGC TTT CAA ATC CCT TTT ATT TCT TTT TTG ATG AAA AAA ACC 387Lys Leu Ser Phe Gln Ile Pro Phe Ile Ser Phe Leu Met Lys Lys Thr
110 115 120TTG CAA TCT CAA AAC ATT CTA GGG CTG TAT TTC TTA GGC GTG TTG AAC 435Leu Gln Ser Gln Asn Ile Leu Gly Leu Tyr Phe Leu Gly Val Leu Asn
125 130 135GGG TTT TTA CCT TGC ATG ATG GTG TAT TCG TTT TTA GCG AGC GTG ATT 483Gly Phe Leu Pro Cys Met Met Val Tyr Ser Phe Leu Ala Ser Val Ile140 145 150 155CTC AGT CAT AGC GCG TTT ATG GGA GCG ATG CTA GGC CTT TCT TTT GGG 531Leu Ser His Ser Ala Phe Met Gly Ala Met Leu Gly Leu Ser Phe Gly
160 165 170CTT GGC ACC AGC ATG CCG TTG TTT TTA ATG GGG ATT TTT TTA AGC AAA 579Leu Gly Thr Ser Met Pro Leu Phe Leu Met Gly Ile Phe Leu Ser Lys
175 180 185ATT TCC GTT TCT TAC AGG AAA TTT TTC AAT CTT TTG TCT AAA ATT TTA 627Ile Ser Val Ser Tyr Arg Lys Phe Phe Asn Leu Leu Ser Lys Ile Leu
190 195 200ATG GGG GTT TTT GGG CTT TAT ATC CTT TAT ATG GGG ATC ATG CTC ATT 675Met Gly Val Phe Gly Leu Tyr Ile Leu Tyr Met Gly Ile Met Leu Ile
205 210 215AAC CAC AAA ATG CCT CAT GCC ATG CAT CAT CAA AAC AAC ACC ACT CAG 723Asn His Lys Met Pro His Ala Met His His Gln Asn Asn Thr Thr Gln220 225 230 235CAT GAT CAT AAA GGA GTG CAT TCG CAT GAA CAC TAACAAAGCC CTTTTTTTGG 776His Asp His Lys Gly Val His Ser His Glu His
240 245ACAGAGACGG CATTATCAAT ATTGA 801
(2) Sequence 876 data:
(i) sequence characteristics:
(A) length: 246 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 876: met Gln Met Met His Asn Leu Ser Phe Leu Gly Met Phe Leu Ala Ala 151015 Leu Ser Met Ser Leu Gly His Cys Val Gly Met Cys Gly Gly Ile Val
20 25 30Ser Ala Phe Ser Gln Ile Arg Phe Ser Lys Val Thr Ser Phe Ser Tyr
35 40 45Gln Leu Thr Cys His Ala Leu Tyr Asn Val GlyArg Ile Ser Thr Tyr
50 55 60Met Leu Leu Gly Ala Ile Ala Ala Ser Leu Gly His Ser Leu Ser Val65 70 75 80Ser Met Gly Phe Arg Gly Val Leu Phe Ile Ser Met Gly Ile Ile Leu
85 90 95Ile Cys Leu Ala Leu Leu Gly Ala Arg Met Glu Lys Leu Ser Phe Gln
100 105 110Ile Pro Phe Ile Ser Phe Leu Met Lys Lys Thr Leu Gln Ser Gln Asn
115 120 125lle Leu Gly Leu Tyr Phe Leu Gly Val Leu Asn Gly Phe Leu Pro Cys
130 135 140Met Met Val Tyr Ser Phe Leu Ala Ser Val Ile Leu Ser His Ser Ala145 150 155 160Phe Met Gly Ala Met Leu Gly Leu Ser Phe Gly Leu Gly Thr Ser Met
165 170 175Pro Leu Phe Leu Met Gly Ile Phe Leu Ser Lys Ile Ser Val Ser Tyr
180 185 190Arg Lys Phe Phe Asn Leu Leu Ser Lys Ile Leu Met Gly Val Phe Gly
195 200 205Leu Tyr Ile Leu Tyr Met Gly Ile Met Leu Ile Asn His Lys Met Pro
210 215 220His Ala Met His His Gln Asn Asn Thr Thr Gln His Asp His Lys Gly225 230 235 240Val His Ser His Glu His
245
(2) Sequence 877 data:
(i) sequence characteristics:
(A) length: 735bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...693
(D) Other information:
(xi) Description of the sequence: sequence 877: AAC TGC CTN TCN TCG CTC AAC ACG ATT GTA TTA AAC CAT AAT AAA TTG 48Asn Cys Xaa Xaa Ser Leu Ash Thr Ile Val Leu Asn His Asn Lys Leu 151015 TAT TCT TTA GAA AAA CGA GGG TAT GTG ATA GAG GTG GAT TTA AAT GAT 96Tyr Ser Leu Glu Lys Arg Gly Tyr Val Ile Glu Val Asp Leu Asn Asp
20 25 30TTT GAT TCG TAT AAT GTC TAT AAA ACG CCA ACT ATA GGC AGT TTT AAG 144Phe Asp Ser Tyr Asn Val Tyr Lys Thr Pro Thr Ile Gly Ser Phe Lys
35 40 45TTT TTT TCA TCT AAT CGT TTG GAT AAA GGG GTG TTT TAT GAT AAA AAT 192Phe Phe Ser Ser Asn Arg Leu Asp Lys Gly Val Phe Tyr Asp Lys Asn
50 55 60CGG GTG TAT TAC GAT CGC TAC TAT TTA GAT TAT AAC GAT TTT AAA CCA 240Arg Val Tyr Tyr Asp Arg Tyr Tyr Leu Asp Tyr Asn Asp Phe Lys Pro65 70 75 80AAA CTT TAT CCC GTT GTG GAA AAA TCG GCA TCT AAA AAA TCT CAA AAA 288Lys Leu Tyr Pro Val Val Glu Lys Ser Ala Ser Lys Lys Ser Gln Lys
85 90 95GGC GAA AAA GGG AAC GCT CCT ATT TAT TTG CAA GAA AGG CAT AAA GCT 336Gly Glu Lys Gly Asn Ala Pro Ile Tyr Leu Gln Glu Arg His Lys Ala
100 105 110AAA GAA AAT AAA CAG CCT TTA GAA GAA AAC AAA GTT AAA CCA AGA AAT384Lys Glu Asn Lys Gln Pro Leu Glu Glu Asn Lys Val Lys Pro Arg Asn
115 120 125AGC GGG TTT GAA GAA GAA GAG GTT AAA ACC AGA AGG CCT GAG CCT ATT 432Ser Gly Phe Glu Glu Glu Glu Val Lys Thr Arg Arg Pro Glu Pro Ile
130 135 140AGG GAT CAA AAT AAC GCC ACC CAA CAA GGC GAA ACA AAA AAC AAT GAA 480Arg Asp Gln Asn Asn Ala Thr Gln Gln Gly Glu Thr Lys Asn Asn Glu145 150 155 160AGT AAA AAC GCT CCT GTC TTA AAA GAA AAC GCC GCT AAA AAA GAA GTG 528Ser Lys Asn Ala Pro Val Leu Lys Glu Asn Ala Ala Lys Lys Glu Val
165 170 175CCA AAA CCA AAT TCT AAA GAA GAA AAA CGC CGC TTG AAA GAA GAA AAG 576Pro Lys Pro Asn Ser Lys Glu Glu Lys Arg Arg Leu Lys Glu Glu Lys
180 185 190AAA AAA GCC AAA GCC GAA CAA AGA GCG AGA GAA TTT GAA CAA AGA GCG 624Lys Lys Ala Lys Ala Glu Gln Arg Ala Arg Glu Phe Glu Gln Arg Ala
195 200 205AGA GAG CAT CAA GAA AGA GAT GAA AAA GAG CTT GAA GAA AGA AGA AAA 672Arg Glu His Gln Glu Arg Asp Glu Lys Glu Leu Glu Glu Arg Arg Lys
210 215 220GCT TTA GAA ATG AAT AAG AAG TAGGCCTATG CCAGCTAGGC AATCTTTTAC AGAT 727Ala Leu Glu Met Asn Lys Lys225 230TTGAAAAA 735
(2) Sequence 878 data:
(i) sequence characteristics:
(A) length: 231 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 878: asn Cys Xaa Xaa Ser Leu Asn Thr Ile Val Leu Asn His Asn Lys Leu 151015 Tyr Ser Leu Glu Lys Arg Gly Tyr Val Ile Glu Val Asp Leu Asn Asp
20 25 30Phe Asp Ser Tyr Asn Val Tyr Lys Thr Pro Thr Ile Gly Ser Phe Lys
35 40 45Phe Phe Ser Ser Asn Arg Leu Asp Lys Gly Val Phe Tyr Asp Lys Asn
50 55 60Arg Val Tyr Tyr Asp Arg Tyr Tyr Leu Asp Tyr Asn Asp Phe Lys Pro65 70 75 80Lys Leu Tyr Pro Val Val Glu Lys Ser Ala Ser Lys Lys Ser Gln Lys
85 90 95Gly Glu Lys Gly Asn Ala Pro Ile Tyr Leu Gln Glu Arg His Lys Ala
100 105 110Lys Glu Asn Lys Gln Pro Leu Glu Glu Asn Lys Val Lys Pro Arg Asn
115 120 125Ser Gly Phe Glu Glu Glu Glu Val Lys Thr Arg Arg Pro Glu Pro Ile
130 135 140Arg Asp Gln Asn Asn Ala Thr Gln Gln Gly Glu Thr Lys Asn Asn Glu145 150 155 160Ser Lys Asn Ala Pro Val Leu Lys Glu Asn Ala Ala Lys Lys Glu Val
165 170 175Pro Lys Pro Asn Ser Lys Glu Glu Lys Arg Arg Leu Lys Glu Glu Lys
180 185 190Lys Lys Ala Lys Ala Glu Gln Arg Ala Arg Glu Phe Glu Gln Arg Ala
195 200 205Arg Glu His Gln Glu Arg Asp Glu Lys Glu Leu Glu Glu Arg Arg Lys
210 215 220Ala Leu Glu Met Asn Lys Lys225 230
(2) Sequence 879 data:
(i) sequence characteristics:
(A) length: 1047bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 34...1005
(D) Other information:
(xi) Description of the sequence: sequence 879: AGAAAGAAAC CATTCAAGGA ACGCATTGAT TTG ATG AAT AAA CCA TTT TTA ATC 54
Met Asn Lys Pro Phe Leu Ile
1 5TTA CTC ATA GCC CTA ATT GTC TTT AGC GGC TGT AAC ATG AGA AAA TAT 102Leu Leu Ile Ala Leu Ile Val Phe Ser Gly Cys Asn Met Arg Lys Tyr
10 15 20TTC AAA CCC GCT AAA CAC CAA ATT AAA GGC GAA GCG TAT TTC CCT AAC 150Phe Lys Pro Ala Lys His Gln Ile Lys Gly Glu Ala Tyr Phe Pro Asn
25 30 35CAT TTG CAA GAA AGT ATC GTT TCG TCT AAT CGT TAT GGA GCC ATT TTG 198His Leu Gln Glu Ser Ile Val Ser Ser Asn Arg Tyr Gly Ala Ile Leu40 45 50 55AAA AAT GGA GCG GTT ATA GGC GAT AAA GGT TTA ACG CAG CTA AGA ATC 246Lys Asn Gly Ala Val Ile Gly Asp Lys Gly Leu Thr Gln Leu Arg Ile
6065 70GGT AAG AAC TTC AAT TAC GAA AGC AGT TTT TTA AAT GAG AGT CAA GGG 294Gly Lys Asn Phe Asn Tyr Glu Ser Ser Phe Leu Asn Glu Ser Gln Gly
75 80 85TTT TTT ATT CTT GCG CAA GAT TGT TTG AAC AAG ATT GAT AAA AAA ACA 342Phe Phe Ile Leu Ala Gln Asp Cys Leu Asn Lys Ile Asp Lys Lys Thr
90 95 100AAC AAA AGC AAG GTG GCT AAG ACT GAA GAA ACG GAA TTG AAA TTA AAG 390Asn Lys Ser Lys Val Ala Lys Thr Glu Glu Thr Glu Leu Lys Leu Lys
105 110 115GGC GTT GAA GCG GAA GTC CAA GAT AAA GTC TGT CAT CAA GTG GAA TTG 438Gly Val Glu Ala Glu Val Gln Asp Lys Val Cys His Gln Val Glu Leu120 125 130 135ATT AGC AAT AAC CCT AAC GCC AGC CAA CAA TCT ATC GTT ATT CCT TTG 486Ile Ser Asn Asn Pro Asn Ala Ser Gln Gln Ser Ile Val Ile Pro Leu
140 145 150GAG ACT TTT GCC TTG AGC GCA AGC GTT AAA GGG AAT CTT TTA GCG GTG 534Glu Thr Phe Ala Leu Ser Ala Ser Val Lys Gly Asn Leu Leu Ala Val
155 160 165GTG TTA GCG GAC AAT TCA GCG AAC TTA TAC GAC ATC ACT TCT CAA AAA 582Val Leu Ala Asp Asn Ser Ala Asn Leu Tyr Asp Ile Thr Ser Gln Lys
170 175 180TTG CTT TTT AGT GAG AAA GGT TCC CCA AGC ACC ACG ATC AAT TCT TTA 630Leu Leu Phe Ser Glu Lys Gly Ser Pro Ser Thr Thr Ile Asn Ser Leu
185 190 195ATG GCG ATG CCT ATT TTT ATG GAT ACG GTC GTG GTG TTC CCC ATG CTA 678Met Ala Met Pro Ile Phe Met Asp Thr Val Val Val Phe Pro Met Leu200 205 210 215GAT GGG CGC TTG TTG GTC GTG GAT TAT GTG CAC GGA AAC CCT ACG CCT726Asp Gly Arg Leu Leu Val Val Asp Tyr Val His Gly Asn Pro Thr Pro
220 225 230ATT AGA AAC ATT GTT ATC AGC AGC GAT AAG TTT TTT AAC AAT ATC ACC 774Ile Arg Asn Ile Val Ile Ser Ser Asp Lys Phe Phe Asn Asn Ile Thr
235 240 245TAC CTT ATC GTA GAT GGC AAT AAC ATG ATC GCT TCT ACA GGG AAA AGG 822Tyr Leu Ile Val Asp Gly Asn Asn Met Ile Ala Ser Thr Gly Lys Arg
250 255 260ATA CTC TCA GTA GTG AGC GGT CAA GAG TTC AAC TAT GAT GGG GAT ATT 870Ile Leu Ser Val Val Ser Gly Gln Glu Phe Asn Tyr Asp Gly Asp Ile
265 270 275GTG GAT TTG CTT TAT GAT AAG GGG ACT TTA TAT GTG CTC ACG CTA GAC 918Val Asp Leu Leu Tyr Asp Lys Gly Thr Leu Tyr Val Leu Thr Leu Asp280 285 290 295GGG CAG ATT TTG CAA ATG GAT AAG AGT TTG AGG GAA TTA AAC AGC GTG 966Gly Gln Ile Leu Gln Met Asp Lys Ser Leu Arg Glu Leu Asn Ser Val
300 305 310AAA CTG CCT NTC NTC GCT CAA CAC GAT TGT ATT AAA CCA TAATAAATTG TA 1017Lys Leu Pro Xaa Xaa Ala Gln His Asp Cys Ile Lys Pro
315 320TTCTTTAGAA AAACGAGGGT ATGTGATAGA 1047
(2) Sequence 880 data:
(i) sequence characteristics:
(A) length: 324 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of thesequence: sequence 880: met Asn Lys Pro Phe Leu Ile Leu Leu Ile Ala Leu Ile Val Phe Ser 151015 Gly Cys Asn Met Arg Lys Tyr Phe Lys Pro Ala Lys His Gln Ile Lys
20 25 30Gly Glu Ala Tyr Phe Pro Asn His Leu Gln Glu Ser Ile Val Ser Ser
35 40 45Asn Arg Tyr Gly Ala Ile Leu Lys Asn Gly Ala Val Ile Gly Asp Lys
50 55 60Gly Leu Thr Gln Leu Arg Ile Gly Lys Asn Phe Asn Tyr Glu Ser Ser65 70 75 80Phe Leu Asn Glu Ser Gln Gly Phe Phe Ile Leu Ala Gln Asp Cys Leu
85 90 95Asn Lys Ile Asp Lys Lys Thr Asn Lys Ser Lys Val Ala Lys Thr Glu
100 105 110Glu Thr Glu Leu Lys Leu Lys Gly Val Glu Ala Glu Val Gln Asp Lys
115 120 125Val Cys His Gln Val Glu Leu Ile Ser Asn Asn Pro Asn Ala Ser Gln
130 135 140Gln Ser Ile Val Ile Pro Leu Glu Thr Phe Ala Leu Ser Ala Ser Val145 150 155 160Lys Gly Asn Leu Leu Ala Val Val Leu Ala Asp Asn Ser Ala Asn Leu
165 170 175Tyr Asp Ile Thr Ser Gln Lys Leu Leu Phe Ser Glu Lys Gly Ser Pro
180 185 190Ser Thr Thr Ile Asn Ser Leu Met Ala Met Pro Ile Phe Met Asp Thr
195 200 205Val Val Val Phe Pro Met Leu Asp Gly Arg Leu Leu Val Val Asp Tyr
210 215 220Val His Gly Asn Pro Thr Pro Ile ArgAsn Ile Val Ile Ser Ser Asp225 230 235 240Lys Phe Phe Asn Asn Ile Thr Tyr Leu Ile Val Asp Gly Asn Asn Met
245 250 255Ile Ala Ser Thr Gly Lys Arg Ile Leu Ser Val Val Ser Gly Gln Glu
260 265 270Phe Asn Tyr Asp Gly Asp Ile Val Asp Leu Leu Tyr Asp Lys Gly Thr
275 280 285Leu Tyr Val Leu Thr Leu Asp Gly Gln Ile Leu Gln Met Asp Lys Ser
290 295 300Leu Arg Glu Leu Asn Ser Val Lys Leu Pro Xaa Xaa Ala Gln His Asp305 310 315 320Cys Ile Lys Pro
(2) Sequence 881 data:
(i) sequence characteristics:
(A) length: 410bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...366
(D) Other information:
(xi) Description of the sequence: sequence 881: AGATTAAGGT TTAGT ATG CAT GAA TAC TCG GTC GTT TCT TCT TTA ATC GCT 51
Met His Glu Tyr Ser Val Val Ser Ser Leu Ile Ala
1 5 10CTT TGC GAA GAG CAT GCG AAG AAA AAT CAA GCC CAT AAG ATT GAA AGA 99Leu Cys Glu Glu His Ala Lys Lys Asn Gln Ala His Lys Ile Glu Arg
15 20 25GTC GTG GTC GGT ATT GGT GAA AGA AGT GCT ATG GAT AAG AGC TTG TTT 147Val Val Val Gly Ile Gly Glu Arg Ser Ala Met Asp Lys Ser Leu Phe
30 35 40GTG AGT GCG TTT GAG ACT TTT AGA GAA GAA TCT TTG GTG TGT AAA GAC 195Val Ser Ala Phe Glu Thr Phe Arg Glu Glu Ser Leu Val Cys Lys Asp45 50 55 60GCT ATT TTA GAC ATT GTA GAT GAA AAG GTT GAA TTA GAA TGC AAG GAT 243Ala Ile Leu Asp Ile Val Asp Glu Lys Val Glu Leu Glu Cys Lys Asp
65 70 75TGT TCG CAT GTT TTT AAG CCT AAC GCG CTA GAT TAT GGG GTG TGT GAG 291Cys Ser His Val Phe Lys Pro Asn Ala Leu Asp Tyr Gly Val Cys Glu
80 85 90AAA TGC CAC AGC AAG AAT GTT ATT ATC ACT CAA GGC AAT GAA ATG CGT 339Lys Cys His Ser Lys Asn Val Ile Ile Thr Gln Gly Asn Glu Met Arg
95 100 105TTG TTG TCT TTA GAA ATG TTA GCG GAA TAACCGATGC AAGAAGAATT GAACGCT 393Leu Leu Ser Leu Glu Met Leu Ala Glu
110 115TACCAGCAAG AAATTGA 410
(2) Data of sequence 882:
(i) sequence characteristics:
(A) length: 117 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 882:
Met His Glu Tyr Ser Val Val Ser Ser Leu Ile Ala Leu Cys Glu Glu1 5 10 15His Ala Lys Lys Asn Gln Ala His Lys Ile Glu Arg Val Val Val Gly
20 25 30Ile Gly Glu Arg Ser Ala Met Asp Lys Ser Leu Phe Val Ser Ala Phe
35 40 45Glu Thr Phe Arg Glu Glu Ser Leu Val Cys Lys Asp Ala Ile Leu Asp
50 55 60Ile Val Asp Glu Lys Val Glu Leu Glu Cys Lys Asp Cys Ser His Val65 70 75 80Phe Lys Pro Asn Ala Leu Asp Tyr Gly Val Cys Glu Lys Cys His Ser
85 90 95Lys Asn Val Ile Ile Thr Gln Gly Asn Glu Met Arg Leu Leu Ser Leu
100 105 110Glu Met Leu Ala Glu
115 (2) sequence 883 data: (i) sequence characteristics: length (A): 840 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 769 (D) other information: (xi) Description of the sequence: sequence 883: TTGCAAAAAC TCTCATTAAA AACAAGGAGC AAAAAAG ATG AAA AAG GCG GGC TTT 55
Met Lys Lys Ala Gly Phe
1 5CTT TTT TTA GCG GTA ATG GCT ATC GTT GTT ATG AGT TTA AAC GCT AAA 103Leu Phe Leu Ala Val Met Ala Ile Val Val Met Ser Leu Asn Ala Lys
10 15 20GAT CCG AAT GTG TTG CGT AAG ATT GTT TTT GAG AAA TGT CTG CCT AAT 151Asp Pro Asn Val Leu Arg Lys Ile Val Phe Glu Lys Cys Leu Pro Asn
25 3035TAT GAG AAA AAT CAG AAT CCT TCG CCA TGC ATA GAA GTC AAA CCC GAT 199Tyr Glu Lys Asn Gln Asn Pro Ser Pro Cys Ile Glu Val Lys Pro Asp
40 45 50GCC GGC TAT GTG GTT TTA AAA GAT ATT AAC GGC CCG TTG CAA TAT TTG 247Ala Gly Tyr Val Val Leu Lys Asp Ile Asn Gly Pro Leu Gln Tyr Leu55 60 65 70TTG ATG CCA ACA ACT CAC ATT AGC GGT ATT GAA AGC CCT TTG TTA CTT 295Leu Met Pro Thr Thr His Ile Ser Gly Ile Glu Ser Pro Leu Leu Leu
75 80 85GAT CCT TCT ACG CCT AAC TTT TTT TAT TTA TCC TGG CAA GCG CGT GAT 343Asp Pro Ser Thr Pro Asn Phe Phe Tyr Leu Ser Trp Gln Ala Arg Asp
90 95 100TTT ATG AGT AAA AAA TAC GGC CAA CCC ATT CCT GAT TAT GCG ATT TCT 391Phe Met Ser Lys Lys Tyr Gly Gln Pro Ile Pro Asp Tyr Ala Ile Ser
105 110 115TTG ACG ATT AAC TCT AGC AAA GGG CGA TCG CAA AAC CAT TTT CAT ATC 439Leu Thr Ile Asn Ser Ser Lys Gly Arg Ser Gln Asn His Phe His Ile
120 125 130CAT ATC TCT TGC ATT AGT CTT GAA GCA CGC AAA CAG CTG GAT AAT AAC 487His Ile Ser Cys Ile Ser Leu Glu Ala Arg Lys Gln Leu Asp Asn Asn135 140 145 150CTA AAA AAA ATC AAC AGC CGT TGG TCG CCA TTA CCG GGC GGT TTG AAT 535Leu Lys Lys Ile Asn Ser Arg Trp Ser Pro Leu Pro Gly Gly Leu Asn
155 160 165GGG CAT AAA TAC TTG GCG CGT CGG GTA ACA GAG AGC GAG TTA GTG CAA 583Gly His Lys Tyr Leu Ala Arg Arg Val Thr Glu Ser Glu Leu Val Gln
170 175 180AAA AGC CCG TTT GTC ATG CTT AAT AAA GAA GTG CCT AAT GCG TAC AAA 631Lys Ser Pro Phe Val Met Leu Asn Lys Glu Val Pro Asn Ala Tyr Lys
185 190 195CGC ATG GGG GAC TAT GGC TTA GCG GTG GTG CAA CAA AGC GAT AAC TCC 679Arg Met Gly Asp Tyr Gly Leu Ala Val Val Gln Gln Ser Asp Asn Ser
200 205 210TTT GTC TTA TTA GCG ACA CAA TTT AAC CCA TTG ACT TTA AAT CGC GCT 727Phe Val Leu Leu Ala Thr Gln Phe Asn Pro Leu Thr Leu Asn Arg Ala215 220 225 230TCA GCC GAA GAG ATT CAA GAT CAT GAA TGC GCG ATT TTG CAC TAAAGCGAG 778Ser Ala Glu Glu Ile Gln Asp His Glu Cys Ala Ile Leu His
235240 TTAGATTCTT AAGCTTGAGC GATAACCTTT AAAAAGCGTT ATGGGGTGGT GTTGCAAAAC 838CC 840 (2) data of sequence 884: (i) sequence characteristics: length (A): 244 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 884: met Lys Lys Ala Gly Phe Leu Phe Leu Ala Val Met Ala Ile Val Val 151015 Met Ser Leu Asn Ala Lys Asp Pro Asn Val Leu Arg Lys Ile Val Phe
20 25 30Glu Lys Cys Leu Pro Asn Tyr Glu Lys Asn Gln Asn Pro Ser Pro Cys
35 40 45Ile Glu Val Lys Pro Asp Ala Gly Tyr Val Val Leu Lys Asp Ile Asn
50 55 60Gly Pro Leu Gln Tyr Leu Leu Met Pro Thr Thr His Ile Ser Gly Ile65 70 75 80Glu Ser Pro Leu Leu Leu Asp Pro Ser Thr Pro Asn Phe Phe Tyr Leu
85 90 95Ser Trp Gln Ala Arg Asp Phe Met Ser Lys Lys Tyr Gly Gln Pro Ile
100 105 110Pro Asp Tyr Ala Ile Ser Leu Thr Ile Asn Ser Ser Lys Gly Arg Ser
115 120 125Gln Asn His Phe His Ile His Ile Ser Cys Ile Ser Leu Glu Ala Arg
130 135 140Lys Gln Leu Asp Asn Asn Leu Lys Lys Ile Asn Ser Arg Trp Ser Pro145 150 155 160Leu Pro Gly Gly Leu Asn Gly His Lys Tyr Leu Ala Arg Arg Val Thr
165 170 175Glu Ser Glu Leu Val Gln Lys Ser Pro Phe Val Met Leu Asn Lys Glu
180 185 190Val Pro Asn Ala Tyr Lys Arg Met Gly Asp Tyr Gly Leu Ala Val Val
195 200 205Gln Gln Ser Asp Asn Ser Phe Val Leu Leu Ala Thr Gln Phe Asn Pro
210215220 Leu Thr Leu Asn Arg Ala Ser Ala Glu Glu Ile Gln Asp His Glu Cys 225230235240 Ala Ile Leu His (2) sequence 885 data: (i) sequence characteristics: length (A): 481 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 441 (D) other information: (xi) Description of the sequence: sequence 885: ATATTGAAAG ATAATCAAAA A ATG AAG ACA AGC GCT AAA GTA TTA TTG ACT 51
Met Lys Thr Ser Ala Lys Val Leu Leu Thr
1 5 10TTA TTG ATT GTA ATA TCA TTA GGT AAG GGA TTA AAT AGT CTC ATA TCA 99Leu Leu Ile Val Ile Ser Leu Gly Lys Gly Leu Asn Ser Leu Ile Ser
15 20 25GCT TGG CGT GGC AAA GAT GAT GCG ATC CCC ATT GAA ACA AGA CTC CAT 147Ala Trp Arg Gly Lys Asp Asp Ala Ile Pro Ile Glu Thr Arg Leu His
30 35 40AAA AAC AAA CTG ACA ATC ATT TCT AAA ACA GAC AGC ATA GAA ATC CAA 195Lys Asn Lys Leu Thr Ile Ile Ser Lys Thr Asp Ser Ile Glu Ile Gln
45 50 55GAC ATT CAG TTT AAT AGA GAG AAT TGT TCT CAC ACT TAT ACT AGT AAG 243Asp Ile Gln Phe Asn Arg Glu Asn Cys Ser His Thr Tyr Thr Ser Lys
60 65 70GAT TTG GAA AAA ATT CAA AAA GAT TTA GAA GAG CTT GAA GAA GGA GTG 291Asp Leu Glu Lys Ile Gln Lys Asp Leu Glu Glu Leu Glu Glu Gly Val75 80 85 90CCT GAA TTG TTC GAG GAG CTT GAG CGT GAT GAA GAG TCC ATC GCT AAA 339Pro Glu Leu Phe Glu Glu Leu Glu Arg Asp Glu Glu Ser Ile Ala Lys
95 100 105AAT AAA AAA ACG ATC CAA GAG TAT CAA AAT AAA ATT GCT AAT TTT CAA 387Asn Lys Lys Thr Ile Gln Glu Tyr Gln Asn Lys Ile Ala Asn Phe Gln
110 115 120AAA TAC TAT AAA GAT ATA AAA GAT ATT GAC GAT TAT TCG GCG TTA ATG 435Lys Tyr Tyr Lys Asp Ile Lys Asp Ile Asp Asp Tyr Ser Ala Leu Met
125 130 135GCT CAA TGAACATAAA GATTCTTATA CTTGGGATAA TGATCTTGAT 481Ala Gln
140
(2) Data in sequence 886: (i) sequence characteristics:
(A) length: 140 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (xi) sequence description: sequence 886: met Lys Thr Ser Ala Lys Val Leu Leu Thr Leu Leu Ile Val Ile Ser 151015 Leu Gly Lys Gly Leu Asn Ser Leu Ile Ser Ala Trp Arg GlyLys Asp
20 25 30Asp Ala Ile Pro Ile Glu Thr Arg Leu His Lys Asn Lys Leu Thr Ile
35 40 45Ile Ser Lys Thr Asp Ser Ile Glu Ile Gln Asp Ile Gln Phe Asn Arg
50 55 60Glu Asn Cys Ser His Thr Tyr Thr Ser Lys Asp Leu Glu Lys Ile Gln65 70 75 80Lys Asp Leu Glu Glu Leu Glu Glu Gly Val Pro Glu Leu Phe Glu Glu
85 90 95Leu Glu Arg Asp Glu Glu Ser Ile Ala Lys Asn Lys Lys Thr Ile Gln
100 105 110Glu Tyr Gln Asn Lys Ile Ala Asn Phe Gln Lys Tyr Tyr Lys Asp Ile
115 120 125Lys Asp Ile Asp Asp Tyr Ser Ala Leu Met Ala Gln
130 135 140
(2) Data in sequence 887:
(i) sequence characteristics:
(A) length: 540bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 28...486
(D) Other information:
(xi) Description of the sequence: sequence 887: GAAAATTAGG TAATAAATAC AACCAGT ATG CTA AAA AAA ATA TTT TTA ACC AAC 54
Met Leu Lys Lys Ile PheLeu Thr Asn
1 5AGC TTA GGG ATT TTA TGC TCT AGG ATT TTT GGC TTT TTA CGG GAT TTG 102Ser Leu Gly Ile Leu Cys Ser Arg Ile Phe Gly Phe Leu Arg Asp Leu10 15 20 25ATG ATG GCT AAT ATT CTA GGG GCT GGG GTG TAT AGC GAT ATT TTC TTT 150Met Met Ala Asn Ile Leu Gly Ala Gly Val Tyr Ser Asp Ile Phe Phe
30 35 40GTG GCT TTC AAA TTG CCT AAT TTA TTC AGG CGT ATT TTT GCG GAG GGC 198Val Ala Phe Lys Leu Pro Asn Leu Phe Arg Arg Ile Phe Ala Glu Gly
45 50 55TCT TTT TCA CAA AGC TTT TTA CCG AGC TTC ATA CGA AGT TCT ATT AAA 246Ser Phe Ser Gln Ser Phe Leu Pro Ser Phe Ile Arg Ser Ser Ile Lys
60 65 70GGG AGC TTT GCG AGT TTG GTA GGG CTT ATT TTT TGT ATC GTT TTA TTC 294Gly Ser Phe Ala Ser Leu Val Gly Leu Ile Phe Cys Ile Val Leu Phe
75 80 85ATG TGG TGC TTA TTG GTG GCG TTA AAT CCC TTA TGG CTA GCT AAA CTC 342Met Trp Cys Leu Leu Val Ala Leu Asn Pro Leu Trp Leu Ala Lys Leu90 95 100 105CTA GCT TAC GGC TTT GAT GAA GAA ACG CTC AAA TTA TGC GCC CCT ATT 390Leu Ala Tyr Gly Phe Asp Glu Glu Thr Leu Lys Leu Cys Ala Pro Ile
110 115 120GTA GCG ATC AAT TTT TGG NAT CTT TTA TTG GTG TTT ATC ACC ACC TTT 438Val Ala Ile Asn Phe Trp Xaa Leu Leu Leu Val Phe Ile Thr Thr Phe
125 130 135TTA GGC GCG CTT TTA CAA NTA CAA ACA CAG CTT TTT TGC CAG CGC TTA T 487Leu Gly Ala Leu Leu Gln Xaa Gln Thr Gln Leu Phe Cys Gln Arg Leu
140145150 AGCGCAAGCT TACTCAATGT ATGCATGATT TTAGCCCTTT TGATTTCTAA AGA 540 (2) sequence 888 data: (i) sequence characteristics: length (A): 153 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 888: met Leu Lys Lys Ile Phe Leu Thr Asn Ser Leu Gly Ile Leu Cys Ser 151015 Arg Ile Phe Gly Phe Leu Arg Asp Leu Met Met Ala Asn Ile Leu Gly
20 25 30Ala Gly Val Tyr Ser Asp Ile Phe Phe Val Ala Phe Lys Leu Pro Asn
35 40 45Leu Phe Arg Arg Ile Phe Ala Glu Gly Ser Phe Ser Gln Ser Phe Leu
50 55 60Pro Ser Phe Ile Arg Ser Ser Ile Lys Gly Ser Phe Ala Ser Leu Val65 70 75 80Gly Leu Ile Phe Cys Ile Val Leu Phe Met Trp Cys Leu Leu Val Ala
85 90 95Leu Asn Pro Leu Trp Leu Ala Lys Leu Leu Ala Tyr Gly Phe Asp Glu
100 105 110Glu Thr Leu Lys Leu Cys Ala Pro Ile Val Ala Ile Asn Phe Trp Xaa
115 120 125Leu Leu Leu Val Phe Ile Thr Thr Phe Leu Gly Ala Leu Leu Gln Xaa
130135140 Gln Thr Gln Leu Phe Cys Gln Arg Leu 145150 (2) sequence 889 data: (i) sequence characteristics: length (A): 1080 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1016 (D) other information: (xi) Description of the sequence: sequence 889: TTCTTTGTTC AGATTAATCGTTCTTAAAAG GAAGCGTG ATG CTT AAA ACC TAT CAT 56
Met Leu Lys Thr Tyr His
1 5ATC GCC TTA GCT TGC GTG ATT TTA GCG GTG GTG GTG CTG TTG TTT GGA 104Ile Ala Leu Ala Cys Val Ile Leu Ala Val Val Val Leu Leu Phe Gly
10 15 20GGG GAG TCC TTG AGC TTG GAA GAA TGG CAA GAA GTG TGC CTT AAT GTG 152Gly Glu Ser Leu Ser Leu Glu Glu Trp Gln Glu Val Cys Leu Asn Val
25 30 35AAA AAC CAC TTT TTG CAC AAT GAA GAA CTG AGC TCT TTA AGT ATT ATT 200Lys Asn His Phe Leu His Ash Glu Glu Leu Ser Ser Leu Ser Ile Ile
40 45 50ATT TTA GAA ATA CGA CTA CCA CGA GTG ATT TTA GCG CTC CTG GTG GGA 248Ile Leu Glu Ile Arg Leu Pro Arg Val Ile Leu Ala Leu Leu Val Gly55 60 65 70GCG AGT TTG TCT GGG AGT GGG GTG GTG ATG CAA ACG ATT TTT AGA AAC 296Ala Ser Leu Ser Gly Ser Gly Val Val Met Gln Thr Ile Phe Arg Asn
75 80 85CCC TTA GTG GAT CCC TTT TTA CTA GGG ATT TCT AGC GGG GCG ATG CTA 344Pro Leu Val Asp Pro Phe Leu Leu Gly Ile Ser Ser Gly Ala Met Leu
90 95 100GGC GTG GCG ATG GCG ATA GCG GTA GTG GAG TCT AAC ATT GCG ATT TTG 392Gly Val Ala Met Ala Ile Ala Val Val Glu Ser Asn Ile Ala Ile Leu
105 110 115GCG TTT TTT GGG GCG ATT TTA GCT AGC CTT GCT GTT TTG GCG ATG AAT 440Ala Phe Phe Gly Ala Ile Leu Ala Ser Leu Ala Val Leu Ala Met Asn
120 125 130AGG GTT TTG GGT AAT TCC GTC CTT TCG TTG GTG CTT TCA GGG GTG GTG 488Arg Val Leu Gly Asn Ser Val Leu Ser Leu Val Leu Ser Gly Val Val135 140 145 150TTG AGC GCG TTT TTA AGC GCC TTAGCC GGA GCG ATA AAA TTC TTT GTG 536Leu Ser Ala Phe Leu Ser Ala Leu Ala Gly Ala Ile Lys Phe Phe Val
155 160 165ATC CCC CAA AAA GCG CAA GCG ATT GTC GTG TGG CTT TTA GGG AGC TTG 584Ile Pro Gln Lys Ala Gln Ala Ile Val Val Trp Leu Leu Gly Ser Leu
170 175 180TCG TTG AGC AGT TAT AAG GAT TGC TTG ATC GCT TTC ATA GGG CTA TCT 632Ser Leu Ser Ser Tyr Lys Asp Cys Leu Ile Ala Phe Ile Gly Leu Ser
185 190 195TTA GGC TTT ATC CCG CTT TTT TTG TTA AGG TGG CGC ATC AAT TTA TTG 680Leu Gly Phe Ile Pro Leu Phe Leu Leu Arg Trp Arg Ile Asn Leu Leu
200 205 210AGC TTG AGC GAT GCG CAA AGT TTG AGC TTG GGG ATT AAC CCG GTG CTG 728Ser Leu Ser Asp Ala Gln Ser Leu Ser Leu Gly Ile Asn Pro Val Leu215 220 225 230TTG CGA TCG CTT TGT TTG GTG TGC GTG AGC GTT GCG AGC GCT TTA GCG 776Leu Arg Ser Leu Cys Leu Val Cys Val Ser Val Ala Ser Ala Leu Ala
235 240 245GTG AGC GTG TCC GGC ACG ATT GGC TGG ATT GGG TTA GTC ATT CCG CAT 824Val Ser Val Ser Gly Thr Ile Gly Trp Ile Gly Leu Val Ile Pro His
250 255 260GTG GCT AGG TTG TTT TTT GGG GCG AAT TTG CAA AAA CTG CTT TTA AGT 872Val Ala Arg Leu Phe Phe Gly Ala Asn Leu Gln Lys Leu Leu Leu Ser
265 270 275TCT TTG TTA ATG GGA GCG TTT TTC TTG CTT CTA GCG GAT GTG GTG GCT 920Ser Leu Leu Met Gly Ala Phe Phe Leu Leu Leu Ala Asp Val Val Ala
280 285 290AAA ACC ATT ACC CCC TAT GAT TTA CCG GTA GGC ATT GCG ACA AGC GTT 968Lys Thr Ile ThrPro Tyr Asp Leu Pro Val Gly Ile Ala Thr Ser Val295 300 305 310TTA GGA GCG CCT TTC TTC TTG TGG CTT TTG TTT AGA ACT AGG GGG GTG T 1017Leu Gly Ala Pro Phe Phe Leu Trp Leu Leu Phe Arg Thr Arg Gly Val
315320325 GATGGTTTTA GAAGTTAAAA ACCTGTCCTT TAAATATTCT CAAAAACTCA TTTTGGATAA 1077ATT 1080 (2) sequence 890 data: (i) sequence characteristics: length (A): 326 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 890: met Leu Lys Thr Tyr His Ile Ala Leu Ala Cys Val Ile Leu Ala Val 151015 Val Val Leu Leu Phe Gly Gly Glu Ser Leu Ser Leu Glu Glu Trp Gln
20 25 30Glu Val Cys Leu Asn Val Lys Asn His Phe Leu His Asn Glu Glu Leu
35 40 45Ser Ser Leu Ser Ile Ile Ile Leu Glu Ile Arg Leu Pro Arg Val Ile
50 55 60Leu Ala Leu Leu Val Gly Ala Ser Leu Ser Gly Ser Gly Val Val Met65 70 75 80Gln Thr Ile Phe Arg Asn Pro Leu Val Asp Pro Phe Leu Leu Gly Ile
85 90 95Ser Ser Gly Ala Met Leu Gly Val Ala Met Ala Ile Ala Val Val Glu
100 105 110Ser Asn Ile Ala Ile Leu Ala Phe Phe Gly Ala Ile Leu Ala Ser Leu
115 120 125Ala Val Leu Ala Met Asn Arg Val Leu Gly Asn Ser Val Leu Ser Leu
130 135 140Val Leu Ser Gly Val Val Leu Ser Ala Phe Leu Ser Ala Leu Ala Gly145 150 155 160Ala Ile Lys Phe Phe Val Ile Pro Gln Lys Ala Gln Ala Ile Val Val
165 170 175Trp Leu Leu Gly Ser Leu Ser Leu Ser Ser Tyr Lys Asp Cys Leu Ile
180 185 190Ala Phe Ile Gly Leu Ser Leu Gly Phe Ile Pro Leu Phe Leu Leu Arg
195 200 205Trp Arg Ile Asn Leu Leu Ser Leu Ser Asp Ala Gln Ser Leu Ser Leu
210 215 220Gly Ile Asn Pro Val Leu Leu Arg Ser Leu Cys Leu Val Cys Val Ser225 230 235 240Val Ala Ser Ala Leu Ala Val Ser Val Ser Gly Thr Ile Gly Trp Ile
245 250 255Gly Leu Val Ile Pro His Val Ala Arg Leu Phe Phe Gly Ala Asn Leu
260 265 270Gln Lys Leu Leu Leu Ser Ser Leu Leu Met Gly Ala Phe Phe Leu Leu
275 280 285Leu Ala Asp Val Val Ala Lys Thr Ile Thr Pro Tyr Asp Leu Pro Val
290 295 300Gly Ile Ala Thr Ser Val Leu Gly Ala Pro Phe Phe Leu Trp Leu Leu305 310 315 320Phe Arg Thr Arg Gly Val
325 (2) sequence 891 data: (i) sequence characteristics: length (A): 410bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 363 (D) other information: (xi) Description of the sequence: sequence 891: CTAGCTAAAA TCGCCCCAAA AAACGCCAAA ATCGCA ATG TTA GAC TCC ACT ACC 54
Met Leu Asp Ser Thr Thr
1 5GCTATC GCC ATC GCC ACG CCT AGC ATC GCC CCG CTA GAA ATC CCT AGT 102Ala Ile Ala Ile Ala Thr Pro Ser Ile Ala Pro Leu Glu Ile Pro Ser
10 15 20AAA AAG GGA TCC ACT AAG GGG TTT CTA AAA ATC GTT TGC ATC ACC ACC 150Lys Lys Gly Ser Thr Lys Gly Phe Leu Lys Ile Val Cys Ile Thr Thr
25 30 35CCA CTC CCA GAC AAA CTC GCT CCC ACC AGG AGC GCT AAA ATC ACT CGT 198Pro Leu Pro Asp Lys Leu Ala Pro Thr Arg Ser Ala Lys Ile Thr Arg
40 45 50GGT AGT CGT ATT TCT AAA ATAATA ATA CTT AAA GAG CTC AGT TCT TCA 246Gly Ser Arg Ile Ser Lys Ile Ile Ile Leu Lys Glu Leu Ser Ser Ser55 60 65 70TTG TGC AAA AAG TGG TTT TTC ACA TTA AGG CAC ACT TCT TGC CAT TCT 294Leu Cys Lys Lys Trp Phe Phe Thr Leu Arg His Thr Ser Cys His Ser
75 80 85TCC AAG CTC AAG GAC TCC CCT CCA AAC AAC AGC ACC ACC ACC GCT AAA 342Ser Lys Leu Lys Asp Ser Pro Pro Asn Asn Ser Thr Thr Thr Ala Lys
90 95 100ATC ACG CAA GCT AAG GCG ATA TGATAGGTTT TAAGCATCAC GCTTCCTTTT AAGA 397Ile Thr Gln Ala Lys Ala Ile
105ACGATTAATC TGA 410 (2) sequence 892 data: (i) sequence characteristics: length (A): 109 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 892: met Leu Asp Ser Thr Thr Ala Ile Ala Ile Ala Thr Pro Ser Ile Ala 151015 Pro Leu Glu Ile Pro Ser Lys Lys Gly Ser Thr Lys Gly Phe Leu Lys
20 25 30Ile Val Cys Ile Thr Thr Pro Leu Pro Asp Lys Leu Ala Pro Thr Arg
35 40 45Ser Ala Lys Ile Thr Arg Gly Ser Arg Ile Ser Lys Ile Ile Ile Leu
50 55 60Lys Glu Leu Ser Ser Ser Leu Cys Lys Lys Trp Phe Phe Thr Leu Arg65 70 75 80His Thr Ser Cys His Ser Ser Lys Leu Lys Asp Ser Pro Pro Asn Asn
85 90 95Ser Thr Thr Thr Ala Lys Ile Thr Gln Ala Lys Ala Ile
100105 (2) sequence 893 data: (i) sequence characteristics: length (A): 711 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 662 (D) other information: (xi) Description of the sequence: sequence 893: AGGAAAAATG GCTGGGGTGC AAGGATTCGA ACCTCGGA ATG CCA GGA CCA AAA CCT 56
Met Pro Gly Pro Lys Pro
1 5GGT GCC TTA CCG CTT GGC GAC ACC CCA AAA ACT AAA GAA AGC ATT ATA 104Gly Ala Leu Pro Leu Gly Asp Thr Pro Lys Thr Lys Glu Ser Ile Ile
10 15 20CAA AAG CTT TTT AAA AAA GTC AAG CTA AAA CGC TAT AAT TTT ATC ATG 152Gln Lys Leu Phe Lys Lys Val Lys Leu Lys Arg Tyr Asn Phe Ile Met
25 30 35GAA AAT GGA TTT GAC CCC ATC ATT TAT AAA CGC TAT TTG AAA AAG AAA 200Glu Asn Gly Phe Asp Pro Ile Ile Tyr Lys Arg Tyr Leu Lys Lys Lys
40 45 50GAA ACC TTT TTG CTG TTT AAA AAA ATC GCT CAA GCG TCT GCG TTT AAA 248Glu Thr Phe Leu Leu Phe Lys Lys Ile Ala Gln Ala Ser Ala Phe Lys55 60 65 70AAT TTA AAA CTC CAA CTC AAA CGA AGA GAA ATA ATC AACCGC TAT GTT 296Asn Leu Lys Leu Gln Leu Lys Arg Arg Glu Ile Ile Asn Arg Tyr Val
75 80 85TCT CAA GCT TTG GGG GAT TTA AAA AAA GGG TTT AGA TAC GCT AAA GTA 344Ser Gln Ala Leu Gly Asp Leu Lys Lys Gly Phe Arg Tyr Ala Lys Val
90 95 100GAA CAC CAA ATC CrA AAA ATC TAT TTC ACG CAC CCT AGC TAT TTG AAA 392Glu His Gln Ile Leu Lys Ile Tyr Phe Thr His Pro Ser Tyr Leu Lys
105 110 115GCC TTT AAA ATA GAA GAA GCC TAT TAC ACC AAC CAC CTG AAA GCC CAT 440Ala Phe Lys Ile Glu Glu Ala Tyr Tyr Thr Asn His Leu Lys Ala His
120 125 130TTA AAA GAA ACG CAA AAA ACC CTA AAA GCC CTA GAT TAC CCC TTT GAT 488Leu Lys Glu Thr Gln Lys Thr Leu Lys Ala Leu Asp Tyr Pro Phe Asp135 140 145 150TTT AAG ACT ATC CAA GCG AGC GTG AAA AAA AGG GCT TAT CAA AAA CCA 536Phe Lys Thr Ile Gln Ala Ser Val Lys Lys Arg Ala Tyr Gln Lys Pro
155 160 165GTT GTT AAA AAA GAA AAA CCC CCT AAA AGC GTG AAT GTC AAT TGC GAA 584Val Val Lys Lys Glu Lys Pro Pro Lys Ser Val Asn Val Asn Cys Glu
170 175 180GGT TTG AGC GAT TTC ACT AAA AAG CAA TTT TTA AAG CTC AAA CGC GCT 632Gly Leu Ser Asp Phe Thr Lys Lys Gln Phe Leu Lys Leu Lys Arg Ala
185 190 195TGT AAC GAT AAT ACG CTG CGC ACG CCC CCT TGAGAGCTGA CCATGCAACT GCC 685Cys Asn Asp Asn Thr Leu Arg Thr Pro Pro
200 205GATCGGGTTT TGCGGGGTGC AAGTTT 711
(2) Sequence 894 data: (i) sequence characteristics:
(A) length: 208 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 894: met Pro Gly Pro Lys Pro Gly Ala Leu Pro Leu Gly Asp Thr Pro Lys 151015 Thr Lys Glu Ser Ile Ile Gln Lys Leu Phe Lys Lys Val Lys Leu Lys
20 25 30Arg Tyr Asn Phe Ile Met Glu Asn Gly Phe Asp Pro Ile Ile Tyr Lys
35 40 45Arg Tyr Leu Lys Lys Lys Glu Thr Phe Leu Leu Phe Lys Lys Ile Ala
50 55 60Gln Ala Ser Ala Phe Lys Asn Leu Lys Leu Gln Leu Lys Arg Arg Glu65 70 75 80Ile Ile Asn Arg Tyr Val Ser Gln Ala Leu Gly Asp Leu Lys Lys Gly
85 90 95Phe Arg Tyr Ala Lys Val Glu His Gln Ile Leu Lys Ile Tyr Phe Thr
100 105 110His Pro Ser Tyr Leu Lys Ala Phe Lys Ile Glu Glu Ala Tyr Tyr Thr
115 120 125Asn His Leu Lys Ala His Leu Lys Glu Thr Gln Lys Thr Leu Lys Ala
130 135 140Leu Asp Tyr Pro Phe Asp Phe Lys Thr Ile Gln Ala Ser Val Lys Lys145 150 155 160Arg Ala Tyr Gln Lys Pro Val Val Lys Lys Glu Lys Pro Pro Lys Ser
165 170 175Val Asn Val Asn Cys Glu Gly Leu Ser Asp Phe Thr Lys Lys Gln Phe
180 185 190Leu Lys Leu Lys Arg Ala Cys Asn Asp Asn Thr Leu Arg Thr Pro Pro
195 200 205
(2) Sequence 895 data: (i) sequence characteristics:
(A) length: 486 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 85...426
(D) Other information: (xi) sequence description: sequence 895: TGAATCACAG CTGAGACCAT TAGACCCGCT TTACAAATCA TCAAAACTAA ACCCGGCGTG 60AGCCTGGTTT CAAGCGTGTT TTTA ATG TGT TTA GAC ACT CAA GTG CTA GTC 111
Met Cys Leu Asp Thr Gln Val Leu Val
1 5TTT GGG GAT TGC GCG ATT ATC CCT AAC CCT AGC CCT AAA GAA TTA GCC 159Phe Gly Asp Cys Ala Ile Ile Pro Asn Pro Ser Pro Lys Glu Leu Ala10 15 20 25GAG ATC GCT ACC ACT TCC GCA CAA ACC GCC AAG CAA TTC AAT ATT GCG 207Glu Ile Ala Thr Thr Ser Ala Gln Thr Ala Lys Gln Phe Asn Ile Ala
30 35 40CCT AAA GTG GCC TTG CTT TCT TAT GCG ACA GGC GAT TCC GCT CAA GGC 255Pro Lys Val Ala Leu Leu Ser Tyr Ala Thr Gly Asp Ser Ala Gln Gly
45 50 55GAA ATG ATA GAC AAA ATC AAC GAA GCT TTA ACA ATC GCT CAA AAG TTG 303Glu Met Ile Asp Lys Ile Asn Glu Ala Leu Thr Ile Ala Gln Lys Leu
60 65 70GAT CCC CAA TTA GAA ATT GAT GGC CCC TTA CAA TTT GAC GCT TCC ATT 351Asp Pro Gln Leu Glu Ile Asp Gly Pro Leu Gln Phe Asp Ala Ser Ile
75 80 85GAT AAA AGC GTA GCC AAG AAA AAA TGC CTA ACA GCC AAG TGG CTG GGC 399Asp Lys Ser Val Ala Lys Lys Lys Cys Leu Thr Ala Lys Trp Leu Gly90 95 100 105AAG CTA GCG TTT TTA TTT TCC CGG ATT TAAACGCTGG GAACATCGCT TATAAAG 453Lys Leu Ala Phe Leu Phe Ser Arg Ile
110CGGTGCAACG GAGCGCTAAA GCCGTGGCGA TAG 486 (2) sequence 896 data: (i) sequence characteristics: length (A): 114 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 896: mer Cys Leu Asp Thr Gln Val Leu Val Phe Gly Asp Cys Ala Ile Ile 151015 Pro Asn Pro Ser Pro Lys Glu Leu Ala Glu Ile Ala Thr Thr Ser Ala
20 25 30Gln Thr Ala Lys Gln Phe Asn Ile Ala Pro Lys Val Ala Leu Leu Ser
35 40 45Tyr Ala Thr Gly Asp Ser Ala Gln Gly Glu Met Ile Asp Lys Ile Asn
50 55 60Glu Ala Leu Thr Ile Ala Gln Lys Leu Asp Pro Gln Leu Glu Ile Asp65 70 75 80Gly Pro Leu Gln Phe Asp Ala Ser Ile Asp Lys Ser Val Ala Lys Lys
85 90 95Lys Cys Leu Thr Ala Lys Trp Leu Gly Lys Leu Ala Phe Leu Phe Ser
100 105 110Arg Ile
(2) Data of sequence 897: (i) sequence characteristics:
(A) length: 1151 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 38...1111
(D) Other information: (xi) sequence description: sequence 897: AGGGCAGGTT TTCACCCCTA AAAAGATAGT GGATTTC ATG CTC ACT CTC AAA CAC 55
Met Leu Thr Leu Lys His
1 5AAT CAT GGG AGT GTT TTA GAA CCG AGT GCT GGC GAT GGG AGT TTT TTA 103Asn His Gly Ser Val Leu Glu Pro Ser Ala Gly Asp Gly Ser Phe Leu
10 15 20AAG CGC TTA AAA AAG GCC GTA AGG ATT GAA ATC GAT CCT AAA ATC TGC 151Lys Arg Leu Lys Lys Ala Val Arg Ile Glu Ile Asp Pro Lys Ile Cys
25 30 35CCT AAA AAT GCC CTT TGC ATG GAC TTT TTT GAC TAC CCT TTA GAA AAT 199Pro Lys Asn Ala Leu Cys Met Asp Phe Phe Asp Tyr Pro Leu Glu Asn
40 45 50CAA TTT GAC ACC ATT ATT GGT AAC CCG CCC TAT GTC AAG CAC AAG GAT 247Gln Phe Asp Thr Ile Ile Gly Asn Pro Pro Tyr Val Lys His Lys Asp55 60 65 70ATT GCG CCA AGC ACC AAA GAA AAA CTC CAT TAC AGC CTT TTT GAT GAA 295Ile Ala Pro Ser Thr Lys Glu Lys Leu His Tyr Ser Leu Phe Asp Glu
75 80 85AGG AGT AAT CTC TAC TTG TTT TTC ATA GAA AAA GCG ATC AAG CAT TTA 343Arg Ser Asn Leu Tyr Leu Phe Phe Ile Glu Lys Ala Ile Lys His Leu
90 95 l00AAA CCT AAA GGC GAA TTG ATT TTC ATC ACC CCA AGG GAT TTT TTA AAA 391Lys Pro Lys Gly Glu Leu Ile Phe Ile Thr Pro Arg Asp Phe Leu Lys
105 110 115TCC ACT TCT AGC GTG AAA TTA AAC GAA TGG ATT TAT AAA GAA GGC ACG 439Ser Thr Ser Ser Val Lys Leu Asn Glu Trp Ile Tyr Lys Glu Gly Thr
120 125 130ATA ACG CAT TTT TTT GAA CTG GGC GAT CAA AAG GTT TTC CCA AAC GCC 487Ile Thr His Phe Phe Glu Leu Gly Asp Gln Lys Val Phe Pro Asn Ala135 140 145 150ATG CCT AAT TGC GTG ATT TTT CGT TTT TGT AAG GGT AAT TTC AGT AGA 535Met Pro Asn Cys Val Ile Phe Arg Phe Cys Lys Gly Asn Phe Ser Arg
155 160 165ATC ACC AAC GAT GGT TTG CAA TTT TTG TGC AAA AAA GGC ATT TTG TAT 583Ile Thr Asn Asp Gly Leu Gln Phe Leu Cys Lys Lys Gly Ile Leu Tyr
170 175 180TTC CTC AAC CAA TCT TAC ACG CAA AAA TTA AGC GAG GTT TTT AAG GTT 631Phe Leu Asn Gln Ser Tyr Thr Gln Lys Leu Ser Glu Val Phe Lys Val
185 190 195AAA GTG GGG GCA GTG AGC GGG TGC GAT AAG ATT TTT AAA AAT GAA AAA 679Lys Val Gly Ala Val Ser Gly Cys Asp Lys Ile Phe Lys Asn Glu Lys
200 205 210TAC GGG AAT TTA GAA TTT GTC ACC TCA ATC ACG AAA AGA ACC AAT GCT 727Tyr Gly Asn Leu Glu Phe Val Thr Ser Ile Thr Lys Arg Thr Asn Ala215 220 225 230TTA GAA AAA ATG GTT TTT GTC AAT GAG CCT AAT GAT TAT TTA CTC GAG 775Leu Glu Lys Met Val Phe Val Asn Glu Pro Asn Asp Tyr Leu Leu Gln
235 240 245CAT AAA GAC AGC TTA ATG CAA AGA AAG ATT AAA AAA TTC AAT GAA AAT 823His Lys Asp Ser Leu Met Gln Arg Lys Ile Lys Lys Phe Asn Glu Asn
250 255 260AAC TGG TTT GAG TGG GGG AGA ATG CAT CAC ATA TCC CCT AAA AAA CGC 871Asn Trp Phe Glu Trp Gly Arg Met His His Ile Ser Pro Lys Lys Arg
265 270 275ATT TAT GTC AAC GCC AAA ACG CAC CAA AAA AAC CCC TTT TTT ATC CAC 919Ile Tyr Val Asn Ala Lys Thr His Gln Lys Asn Pro Phe Phe Ile His
280 285 290CAA TGC CCT AAT TAT GAC GGC TCT ATT TTA GCG CTA TTC CCT TAT AAC 967Gln Cys Pro Asn Tyr Asp Gly Ser Ile Leu Ala Leu Phe Pro Tyr Asn295 300 305 310CAA AAC CTG GAC TTA CAA AAT CTC TGC GAC AAA CTC AAC GGT ATC AAC 1015Gln Asn Leu Asp Leu Gln Asn Leu Cys Asp Lys Leu Asn Ala Ile Asn
315 320 325TGG CAA GAA TTA GGC TTT GTG TGC GGC GGG CGT TTT TTG TTT TCG CAG 1063Trp Gln Glu Leu Gly Phe Val Cys Gly Gly Arg Phe Leu Phe Ser Gln
330 335 340CGC TCT TTA GAA AAC GCG CTT TTG CCT AAA GAC TTT TTA AAT CTA GGA T 1112Arg Ser Leu Glu Asn Ala Leu Leu Pro Lys Asp Phe Leu Asn Leu Gly
345350355 AAAACTTGTT AGAAACTTTG CAATTAAACC CTGAGCAGC 1151(2) sequence 898 data: (i) sequence characteristics: length (A): 358 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 898: met Leu Thr Leu Lys His Asn His Gly Ser Val Leu Glu Pro Ser Ala 151015 Gly Asp Gly Ser Phe Leu Lys Arg Leu Lys Lys Ala Val Arg Ile Glu
20 25 30Ile Asp Pro Lys Ile Cys Pro Lys Ash Ala Leu Cys Met Asp Phe Phe
35 40 45Asp Tyr Pro Leu Glu Asn Gln Phe Asp Thr Ile Ile Gly Asn Pro Pro
50 55 60Tyr Val Lys His Lys Asp Ile Ala Pro Ser Thr Lys Glu Lys Leu His65 70 75 80Tyr Ser Leu Phe Asp Glu Arg Ser Asn Leu Tyr Leu Phe Phe Ile Glu
85 90 95Lys Ala Ile Lys His Leu Lys Pro Lys Gly Glu Leu Ile Phe Ile Thr
100 105 110Pro Arg Asp Phe Leu Lys Ser Thr Ser Ser Val Lys Leu Asn Glu Trp
115 120 125Ile Tyr Lys Glu Gly Thr Ile Thr His Phe Phe Glu Leu Gly Asp Gln
130 135 140Lys Val Phe Pro Asn Ala Met Pro Asn Cys Val Ile Phe Arg Phe Cys145 150 155 160Lys Gly Asn Phe Ser Arg Ile Thr Asn Asp Gly Leu Gln Phe Leu Cys
165 170 175Lys Lys Gly Ile Leu Tyr Phe Leu Asn Gln Ser Tyr Thr Gln Lys Leu
180 185 190Ser Glu Val Phe Lys Val Lys Val Gly Ala Val Ser Gly Cys Asp Lys
195 200 205Ile Phe Lys Asn Glu Lys Tyr Gly Asn Leu Glu Phe Val Thr Ser Ile
210 215 220Thr Lys Arg Thr Asn Ala Leu Glu Lys Met Val Phe Val Asn Glu Pro225 230 235 240Asn Asp Tyr Leu Leu Gln His Lys Asp Ser Leu Met Gln Arg Lys Ile
245 250 255Lys Lys Phe Asn Glu Asn Asn Trp Phe Glu Trp Gly Arg Met His His
260 265 270Ile Ser Pro Lys Lys Arg Ile Tyr Val Asn Ala Lys Thr His Gln Lys
275 280 285Asn Pro Phe Phe Ile His Gln Cys Pro Asn Tyr Asp Gly Ser Ile Leu
290 295 300Ala Leu Phe Pro Tyr Asn Gln Asn Leu Asp Leu Gln Asn Leu Cys Asp305 310 315 320Lys Leu Asn Ala Ile Asn Trp Gln Glu Leu Gly Phe Val Cys Gly Gly
325 330 335Arg Phe Leu Phe Ser Gln Arg Ser Leu Glu Asn Ala Leu Leu Pro Lys
340 345 350Asp Phe Leu Asn Leu Gly
355 (2) sequence 899 data: (i) sequence characteristics: length (A): 1183 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1130 (D) other information: (xi) Description of the sequence: sequence 899: CCTAAAGCGG AGAATAAAGT TACAGAAGTC CTAGCGAGCA AAACAATGTG ATG GCT 56
Met Ala
1AAG ATC AAT GGT TAT TTG AGC GAA AGG GAT ATT TTA ACG CTC AGT TAT 104Lys Ile Asn Gly Tyr Leu Ser Glu Arg Asp Ile Leu Thr Leu Ser Tyr
5 10 15AAC ATG ACC AGA GAC AAC GCT AAC CGC CCT TTA AGA GCG AAT TTT ACA 152Asn Met Thr Arg Asp Asn Ala Asn Arg Pro Leu Arg Ala Asn Phe Thr
20 25 30GGC ACT TTT TTA CCC TAT TCT TGC GGT GAT TTT AAC GCT TTC CCT AAC 200Gly Thr Phe Leu Pro Tyr Ser Cys Gly Asp Phe Asn Ala Phe Pro Asn35 40 45 50GAG AAA AAC CCT AGC GAT TGT TTG TTT GAA AAC GAC GCT AGT TTG TTT 248Glu Lys Asn Pro SerAsp Cys Leu Phe Glu Asn Asp Ala Ser Leu Phe
55 60 65AAA ACT TAT AGC GTC AAT TTA GTG CAT AAT GTG AGT TTG AAT TAT GAA 296Lys Thr Tyr Ser Val Asn Leu Val His Asn Val Ser Leu Asn Tyr Glu
70 75 80AGA GAA GGG GGG AGC CGT TTT GGT GAT CCT AAA TTA AAA ATC AAT GGC 344Arg Glu Gly Gly Ser Arg Phe Gly Asp Pro Lys Leu Lys Ile Asn Gly
85 90 95TAT ACA AGC ATT AGG AAT GTC CAA ATT GAT CCG CTT TTT AAG CCT AAC 392Tyr Thr Ser Ile Arg Asn Val Gln Ile Asp Pro Leu Phe Lys Pro Asn
100 105 110GAC ATA GCG GCT AGT ATT CCT TTC ACC CCA AAC CCA AAA CTT GGC GAA 440Asp Ile Ala Ala Ser Ile Pro Phe Thr Pro Asn Pro Lys Leu Gly Glu115 120 125 130GAG AAT GAA TGC GTG GCG CAA GGG GGC ATT TAT GAC GCT CTT AAA CAA 488Glu Asn Glu Cys Val Ala Gln Gly Gly Ile Tyr Asp Ala Leu Lys Gln
135 140 145ACT TGC TCC ATC ACT TTT AAA AGC CTT GGA GGG GGT TCT GTG GTG GCT 536Thr Cys Ser Ile Thr Phe Lys Ser Leu Gly Gly Gly Ser Val Val Ala
150 155 160AAT AAA AAT TTA TTC ATC ATC AAT TCT GGG TTT AAT GCG AAC GTG ATC 584Asn Lys Asn Leu Phe Ile Ile Asn Ser Gly Phe Asn Ala Asn Val Ile
165 170 175CAC ACC ATA GAC CAT AAG AAT GAC AAC CTT TTG GAA TAC GGG TTG AAT 632His Thr Ile Asp His Lys Asn Asp Asn Leu Leu Glu Tyr Gly Leu Asn
180 185 190TAC CAA AAC TTA ACC ACT TTT GAT AAA GCG ATC CCT AAT AGC GAA TTA 680Tyr Gln Asn Leu Thr Thr Phe Asp Lys Ala Ile Pro Asn Ser Glu Leu195 200 205210GTC AAA CCC GGC GAT GCC CCT GAC GCA TGC TTA AGG GTT ACA AGC CCC 728Val Lys Pro Gly Asp Ala Pro Asp Ala Cys Leu Arg Val Thr Ser Pro
215 220 225AAT GAT CCC AAC ATG AAC GGG CGT TGC CAA CGA AAT GGC GCT ACG GCG 776Asn Asp Pro Asn Met Asn Gly Arg Cys Gln Arg Asn Gly Ala Thr Ala
230 235 240AAT GTG ATT GGG GTG TAT GCG CAA GCG AAT TAC ACC TTG CAT CCT ATG 824Asn Val Ile Gly Val Tyr Ala Gln Ala Asn Tyr Thr Leu His Pro Met
245 250 255GTA ACT TTA GGG GCA GGG ACT CGT TAT GAT GTC TAT ACT TTA GTG GAT 872Val Thr Leu Gly Ala Gly Thr Arg Tyr Asp Val Tyr Thr Leu Val Asp
260 265 270AAA GAC TGG CAA TTG CAC ATA ACC CAA GGG TTT AGC CCT AGC GCG GCT 920Lys Asp Trp Gln Leu His Ile Thr Gln Gly Phe Ser Pro Ser Ala Ala275 280 285 290TTA AAT GTC TCG CCT TTA GAA AAT TTG AAT TTC AGG CTT TCT TAT GCG 968Leu Asn Val Ser Pro Leu Glu Asn Leu Asn Phe Arg Leu Ser Tyr Ala
295 300 305TAT GTA ACC AGA GGC CCT ATG CCT GGA GGT TTG GTG TGG ATG CGT CAA 1016Tyr Val Thr Arg Gly Pro Met Pro Gly Gly Leu Val Trp Met Arg Gln
310 315 320GAT AAT TTG CGN CTA CAA CCG CAA TTT AAA GCC AGA AAT TGG GCA AAA 1064Asp Asn Leu Xaa Leu Gln Pro Gln Phe Lys Ala Arg Asn Trp Ala Lys
325 330 335TGT GGA ATT TTA ACA CCG AAT ACA GCA GTC AGT ATT TTG ATT TTA GAG 1112Cys Gly Ile Leu Thr Pro Asn Thr Ala Val Ser Ile Leu Ile Leu Glu
340345350 CCG CCG GTT TTG TCC AAT TGATTTCTAA TTACATCAAT CAATTTTCTT CAACGCTT 1168Pro Pro Val Leu Ser Asn 355360 TTTGTAACCA ACTTG 1183(2) sequence 900 data: (i) sequence characteristics: length (A): 360 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 900: met Ala Lys Ile Asn Gly Tyr Leu Ser Glu Arg Asp Ile Leu Thr Leu 151015 Ser Tyr Asn Met Thr Arg Asp Asn Ala Asn Arg Pro Leu Arg Ala Asn
20 25 30Phe Thr Gly Thr Phe Leu Pro Tyr Ser Cys Gly Asp Phe Asn Ala Phe
35 40 45Pro Asn Glu Lys Asn Pro Ser Asp Cys Leu Phe Glu Asn Asp Ala Ser
50 55 60Leu Phe Lys Thr Tyr Ser Val Asn Leu Val His Asn Val Ser Leu Asn65 70 75 80Tyr Glu Arg Glu Gly Gly Ser Arg Phe Gly Asp Pro Lys Leu Lys Ile
85 90 95Asn Gly Tyr Thr Ser Ile Arg Asn Val Gln Ile Asp Pro Leu Phe Lys
100 105 110Pro Asn Asp Ile Ala Ala Ser Ile Pro Phe Thr Pro Asn Pro Lys Leu
115 120 125Gly Glu Glu Asn Glu Cys Val Ala Gln Gly Gly Ile Tyr Asp Ala Leu
130 135 140Lys Gln Thr Cys Ser Ile Thr Phe Lys Ser Leu Gly Gly Gly Ser Val145 150 155 160Val Ala Asn Lys Asn Leu Phe Ile Ile Asn Ser Gly Phe Asn Ala Asn
165 170 175Val Ile His Thr Ile Asp His Lys Asn Asp Asn Leu Leu Glu Tyr Gly
180 185 190Leu Asn Tyr Gln Asn Leu Thr Thr Phe Asp Lys Ala Ile Pro Asn Ser
195 200 205Glu Leu Val Lys Pro Gly Asp Ala Pro Asp Ala Cys Leu Arg Val Thr
210 215 220Ser Pro Asn Asp Pro Asn Met Asn Gly Arg Cys Gln Arg Asn Gly Ala225 230 235 240Thr Ala Asn Val Ile Gly Val Tyr Ala Gln Ala Asn Tyr Thr Leu His
245 250 255Pro Met Val Thr Leu Gly Ala Gly Thr Arg Tyr Asp Val Tyr Thr Leu
260 265 270Val Asp Lys Asp Trp Gln Leu His Ile Thr Gln Gly Phe Ser Pro Ser
275 280 285Ala Ala Leu Asn Val Ser Pro Leu Glu Asn Leu Asn Phe Arg Leu Ser
290 295 300Tyr Ala Tyr Val Thr Arg Gly Pro Met Pro Gly Gly Leu Val Trp Met305 310 315 320Arg Gln Asp Asn Leu Xaa Leu Gln Pro Gln Phe Lys Ala Arg Asn Trp
325 330 335Ala Lys Cys Gly Ile Leu Thr Pro Asn Thr Ala Val Ser Ile Leu Ile
340 345 350Leu Glu Pro Pro Val Leu Ser Asn
355360 (2) sequence 901 data: (i) sequence characteristics: length (A): 431 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 387 (D) other information: (xi) Description of the sequence: sequence 901: AGACTGAATA AAATCGCACT CGCTCCCGCA ATG ACA ACC TGG AAC ATG GGG CTG 54
Met Thr Thr Trp Asn Met Gly Leu
1 5CCC AAA AACAAG TTA ATG AGC GAA CAC ACC ACC ACC ACA ATC AAA GCG 102Pro Lys Asn Lys Leu Met Ser Glu His Thr Thr Thr Thr Ile Lys Ala
10 15 20ATG AAG AGC ATT TTA CCC ATA TTC GCT AGA TCG TTT TTA GTC TTA AGG 150Met Lys Ser Ile Leu Pro Ile Phe Ala Arg Ser Phe Leu Val Leu Arg25 30 35 40GCA TAC ACG CTC ATC AAA CCA AAG ACA ATA GTT GTC ATG CCC AAA GCC 198Ala Tyr Thr Leu Ile Lys Pro Lys Thr Ile Val Val Met Pro Lys Ala
45 50 55TGC CAA ATC GCT CCT AAA CCA GCT TTT GCA ATC ACC ATA CCC AAC AAA 246Cys Gln Ile Ala Pro Lys Pro Ala Phe Ala Ile Thr Ile Pro Asn Lys
60 65 70GGC ACT AGC GTA ACC CCT GAT AAT GAA GTG AAA GCA AAC AGC ATG AAC 294Gly Thr Ser Val Thr Pro Asp Asn Glu Val Lys Ala Asn Ser Met Asn
75 80 85AGA TTC AAT CCG GGT TTA GAT TTA GAA AAC ATC AAA CCA AAA AAC GCC 342Arg Phe Asn Pro Gly Leu Asp Leu Glu Asn Ile Lys Pro Lys Asn Ala
9095100 GCA ATT TCA GCG ATA AAA AAC ACC CAT TTA TAC TGC ACT ACG GCT TGAAA 392Ala Ile Ser Ala Ile Lys Asn Thr His Leu Tyr Cys Thr Thr Ala 105110115 ATTCATTAAA CCTAGTAACG CCCCAATAGT CGCTAATAA 431 (2) sequence 902 data: (i) sequence characteristics: length (A): 119 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 902: met Thr Thr Trp Asn Met Gly Leu Pro Lys Asn Lys Leu Met Ser Glu 151015 His Thr Thr Thr Thr Ile Lys Ala Met Lys Ser Ile Leu Pro Ile Phe
20 25 30Ala Arg Ser Phe Leu Val Leu Arg Ala Tyr Thr Leu Ile Lys Pro Lys
35 40 45Thr Ile Val Val Met Pro Lys Ala Cys Gln Ile Ala Pro Lys Pro Ala
50 55 60Phe Ala Ile Thr Ile Pro Asn Lys Gly Thr Ser Val Thr Pro Asp Asn65 70 75 80Glu Val Lys Ala Asn Ser Met Asn Arg Phe Asn Pro Gly Leu Asp Leu
85 90 95Glu Asn Ile Lys Pro Lys Asn Ala Ala Ile Ser Ala Ile Lys Asn Thr
100 105 110His Leu Tyr Cys Thr Thr Ala
115
(2) Sequence 903 data: (i) sequence characteristics:
(A) length: 671 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 21...599
(D) Other information:
(xi) Description of the sequence: sequence 903: AAGTTTGATA TACTAACAGA ATG AAT ACT TAT AAA AAC AGC TTG AAT CAC 50
Met Asn Thr Tyr Lys Asn Ser Leu Asn His
1 5 10TTT TTA AAT TTA GTG GAT TGT TTA GAA AAA ATC CCC AAT GTG GGT AAA 98Phe Leu Asn Leu Val Asp Cys Leu Glu Lys Ile Pro Asn Val Gly Lys
15 20 25AAG TCC GCC TTT AAA ATG GCG TAT CAT TTG GGT TTA GAA AAC CCC TAT 146Lys Ser Ala Phe Lys Met Ala Tyr His Leu Gly Leu Glu Asn Pro Tyr
30 35 40CTG GCG CTA AAA ATC ACG CAC GCT TTA GAG AAC GCC CTA GAA AAC CTT 194Leu Ala Leu Lys Ile Thr His Ala Leu Glu Asn Ala Leu Glu Asn Leu
45 50 55AAA ACA TGT TCA TCT TGT AAC GCG CTC AGC GAG AGT GAG GTT TGT GAG 242Lys Thr Cys Ser Ser Cys Asn Ala Leu Ser Glu Ser Glu Val Cys Glu
60 65 70ATT TGC TCT GAT GAA AGC CGA CAA AAT TCT CAG CTT TGC ATG GTT TTA 290Ile Cys Ser Asp Glu Ser Arg Gln Asn Ser Gln Leu Cys Met Val Leu75 80 85 90CAC CCA AGA GAT GTG TIT ATT TTA GAA GAT TTA AAG GAT TTT TTA GGG 338His Pro Arg Asp Val Phe Ile Leu Glu Asp Leu Lys Asp Phe Leu Gly
95 100 105CGC TAT TAT GTG TTA AAC TCC ATA GAA GAA GTG GAT TTT AAC GCC CTA 386Arg Tyr Tyr Val Leu Asn Ser Ile Glu Glu Val Asp Phe Asn Ala Leu
110 115 120GAA AAA CGC CTG ATT GAA GAA AAC ATT AAA GAA ATC ATT TTT GCT TTC 434Glu Lys Arg Leu Ile Glu Glu Asn Ile Lys Glu Ile Ile Phe Ala Phe
125 130 135CCT CCC ACT TTA GCT AAT GAT TCT CTA ATG CTT TAT ATT GAA GAC AAA 482Pro Pro Thr Leu Ala Asn Asp Ser Leu Met Leu Tyr Ile Glu Asp Lys
140 145 150TTA CAG CAT TTC CAC CTC ACT TTC ACT AAA ATC GCT CAA GGC GTG CCT 530Leu Gln His Phe His Leu Thr Phe Thr Lys Ile Ala Gln Gly Val Pro155 160 165 170ACT GGA GTG AAT TTT GAA AAC ATT GAC TCA GTT TCG CTC TCA AGG GCG 578Thr Gly Val Asn Phe Glu Asn Ile Asp Ser Val Ser Leu Ser Arg Ala
175 180 185TTT AAT TCA AGG ATC AAA GCA TGAATTTAAA TTTTATGCCC CTATTGCATG CTTA 633Phe Asn Ser Arg Ile Lys Ala
190TAACCATGCG AGCATTGATT TTCATTTCAA TTCTAGTG 671 (2) sequence 904 data: (i) sequence characteristics: length (A): 193 amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 904: met Asn Thr Tyr Lys Asn Ser Leu Asn His Phe Leu Asn Leu Val Asp 151015 Cys Leu Glu Lys Ile Pro Asn Val Gly Lys Lys Ser Ala Phe Lys Met
20 25 30Ala Tyr His Leu Gly Leu Glu Asn Pro Tyr Leu Ala Leu Lys Ile Thr
35 40 45His Ala Leu Glu Asn Ala Leu Glu Asn Leu Lys Thr Cys Ser Ser Cys
50 55 60Asn Ala Leu Ser Glu Ser Glu Val Cys Glu Ile Cys Ser Asp Glu Ser65 70 75 80Arg Gln Asn Ser Gln Leu Cys Met Val Leu His Pro Arg Asp Val Phe
85 90 95Ile Leu Glu Asp Leu Lys Asp Phe Leu Gly Arg Tyr Tyr Val Leu Asn
100 105 110Ser Ile Glu Glu Val Asp Phe Asn Ala Leu Glu Lys Arg Leu Ile Glu
115 120 125Glu Asn Ile Lys Glu Ile Ile Phe Ala Phe Pro Pro Thr Leu Ala Asn
130 135 140Asp Ser Leu Met Leu Tyr Ile Glu Asp Lys Leu Gln His Phe His Leu145 150 155 160Thr Phe Thr Lys Ile Ala Gln Gly Val Pro Thr Gly Val Asn Phe Glu
165 170 175Asn Ile Asp Ser Val Ser Leu Ser Arg Ala Phe Asn Ser Arg Ile Lys
180185190 Ala (2) sequence 905 data: (i) sequence characteristics: length (A): 846 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 793 (D) other information: (xi) Description of the sequence: sequence 905: AAAAAATTCA GGATTAAAAT ATAAA ATG AAA AAA GTT TTA TTT TTG TNG GTA 52
Met Lys Lys Val Leu Phe Leu Xaa Val
1 5ATA AGC TTT TTT GGG GGT TTT TTG AAC GCT TCT AGC TTG TAT GAA AAA 100Ile Ser Phe Phe Gly Gly Phe Leu Asn Ala Ser Ser Leu Tyr Glu Lys10 15 20 25CTG ATT AAT AAA GAA ACG ATC AGC GTT GGC ACA GAA GGC ATT TAC CCC 148Leu Ile Asn Lys Glu Thr Ile Ser Val Gly Thr Glu Gly Ile Tyr Pro
30 35 40CCT TTC ACT TAC CAC AAT AAA GAA GGC AAG CTC ACC GGC TAT GAT GTG 196Pro Phe Thr Tyr His Asn Lys Glu Gly Lys Leu Thr Gly Tyr Asp Val
45 50 55GAA GTG GCT AGG GAG TTG GCC AAA GAG CTT GGC GTG AAG ATC AAA TTC 244Glu Val Ala Arg Glu Leu Ala Lys Glu Leu Gly Val Lys Ile Lys Phe
60 65 70CAC GAA ACT TCA TGG GAT ATC ATG CTG ACA GGT TTG AAA TCG GGG CGT 292His Glu Thr Ser Trp Asp Ile Met Leu Thr Gly Leu Lys Ser Gly Arg
75 80 85TTT GAT ATG GTC GCT AAC CAA GTG AGT TTG GCG ACT AAA AAA CGC CAA 340Phe Asp Met Val Ala Asn Gln Val Ser Leu Ala Thr Lys Lys Arg Gln90 95 100 105GCG GCT TTT GAT AAA AGC TTG CCT TAT AGC TAT TCA GGC ACG ATC ATG 388Ala Ala Phe Asp Lys Ser Leu Pro Tyr Ser Tyr Ser Gly Thr Ile Met
110 115 120CTG GTC AGG AAA GAT GAA AAC CGC ATT AAA GAT ATT AAA GAC ATC AAG 436Leu Val Arg Lys Asp Glu Asn Arg Ile Lys Asp Ile Lys Asp Ile Lys
125 130 135GGT TTG AGA GCG GCT AAC ACT TTA AGC TCC ACT TAT GGG GAA ATC GCT 484Gly Leu Arg Ala Ala Asn Thr Leu Ser Ser Thr Tyr Gly Glu Ile Ala
140 145 150TTT AAA TAC GAC GCT CAA ATC GTT TCG GTG GAT TCT ATG GCG CAA GCT 532Phe Lys Tyr Asp Ala Gln Ile Val Ser Val Asp Ser Met Ala Gln Ala
155 160 165TTG TTG CTG GTG GCG CAA AAA CGA GCC GAT TTG ACC TTA AAT AGT TCT 580Leu Leu Leu Val Ala Gln Lys Arg Ala Asp Leu Thr Leu Asn Ser Ser170 175 180 185TTA GCG ATC TTA AAC TAC CTT AAC ACC CAC AAA GAT AAC CCC TTT AAA 628Leu Ala Ile Leu Asn Tyr Leu Asn Thr His Lys Asp Asn Pro Phe Lys
190 195 200ATC GCA TGG GAG TCC AAA GAA AAA GAT GGG GGC GCT TCC TTT GTT ATT 676Ile Ala Trp Glu Ser Lys Glu Lys Asp Gly Gly Ala Ser Phe Val Ile
205 210 215AAC AAG CAC CAA GAA AAA GCC TTA GAG CTT ATC AAC CAA GCG ATG CAA 724Asn Lys His Gln Glu Lys Ala Leu Glu Leu Ile Asn Gln Ala Met Gln
220 225 230AGA TTG ATC AAC AAA GGG GTT TTA AAA CGC TTA GGC GAA CAA TTT TTT 772Arg Leu Ile Asn Lys Gly Val Leu Lys Arg Leu Gly Glu Gln Phe Phe
235240245 GGA AAA GAT GTC AGC CAG CCC TAATCTGTCT TTGTTTTTTG AATCTTTAGA TTTG 827Gly Lys Asp Val Ser Gln Pro 250255 AGCAAGGAGC GTTTGGAAT 846 (2) sequence 906 data: (i) sequence characteristics: length (A): 256 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 906: met Lys Lys Val Leu Phe Leu Xaa Val Ile Ser Phe Phe Gly Gly Phe 151015 Leu Asn Ala Ser Ser Leu Tyr Glu Lys Leu Ile Asn Lys Glu Thr Ile
20 25 30Ser Val Gly Thr Glu Gly Ile Tyr Pro Pro Phe Thr Tyr His Asn Lys
35 40 45Glu Gly Lys Leu Thr Gly Tyr Asp Val Glu Val Ala Arg Glu Leu Ala
50 55 60Lys Glu Leu G1y Val Lys Ile Lys Phe His Glu Thr Ser Trp Asp Ile65 70 75 80Met Leu Thr Gly Leu Lys Ser Gly Arg Phe Asp Met Val Ala Ash Gln
85 90 95Val Ser Leu Ala Thr Lys Lys Arg Gln Ala Ala Phe Asp Lys Ser Leu
100 105 110Pro Tyr Ser Tyr Ser Gly Thr Ile Met Leu Val Arg Lys Asp Glu Asn
115 120 125Arg Ile Lys Asp Ile Lys Asp Ile Lys Gly Leu Arg Ala Ala Asn Thr
130 135 140Leu Ser Ser Thr Tyr Gly Glu Ile Ala Phe Lys Tyr Asp Ala Gln Ile145 150 155 160Val Ser Val Asp Ser Met Ala Gln Ala Leu Leu Leu Val Ala Gln Lys
165 170 175Arg Ala Asp Leu Thr Leu Asn Ser Ser Leu Ala Ile Leu Asn Tyr Leu
180 185 190Asn Thr His Lys Asp Asn Pro Phe Lys Ile Ala Trp Glu Ser Lys Glu
195 200 205Lys Asp Gly Gly Ala Ser Phe Val Ile Asn Lys His Gln Glu Lys Ala
210 215 220Leu Glu Leu Ile Asn Gln Ala Met Gln Arg Leu Ile Asn Lys Gly Val225 230 235 240Leu Lys Arg Leu Gly Glu Gln Phe Phe Gly Lys Asp Val Ser Gln Pro
2456250255 (2) sequence 907 data: (i) sequence characteristics: length (A): 1423 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1372 (D) other information: (xi) Description of the sequence: sequence 907: CCTAGTTTAT TAAGGAGTTT TT ATG GAA ACG ATT GAT TCG GTG GTG CGT TTG 52
Met Glu Thr Ile Asp Ser Val Val Arg Leu
1 5 10TTA TCT AAT TTG GTG TGG GGG ATT CCC ATG CAA ATT TTA TTA GTA GGC 100Leu Ser Asn Leu Val Trp Gly Ile Pro Met Gln Ile Leu Leu Val Gly
15 20 25ACC GGC TTG TTT TTA ACC TTT TAT CTT AGG GGT TTG CAA TTC AGT AAG 148Thr Gly Leu Phe Leu Thr Phe Tyr Leu Arg Gly Leu Gln Phe Ser Lys
30 35 40ATT TTT TAT GCG ATC AAA ATC CTT TTT GAC AAA GAG TCC CAA TCT AAG 196Ile Phe Tyr Ala Ile Lys Ile Leu Phe Asp Lys Glu Ser Gln Ser Lys
45 50 55GGC GAC ATT TCA CAA TTT TCC GCT CTC ATG CTC TCT TTG GGG GCG ACT 244Gly Asp Ile Ser Gln Phe Ser Ala Leu Met Leu Ser Leu Gly Ala Thr
60 65 70GTA GGC ATT GGG AGT ATC GTA GGC GTA GCG ACC GCT ATT AGC ATC GCA 292Val Gly Ile Gly Ser Ile Val Gly Val Ala Thr Ala Ile Ser Ile Ala75 80 85 90GGG CCA GGA GCG GTG TTT TGG ATG TGG GTT ACT GGG CTT GTT GGC ATG 340Gly Pro Gly Ala Val Phe Trp Met Trp Val Thr Gly Leu Val Gly Met
95 100 105GCG ACT AAG TAT TCT GAG GGG ATT TTA GCG GTG AAA TAC CGG GAA AAA 388Ala Thr Lys Tyr Ser Glu Gly Ile Leu Ala Val Lys Tyr Arg Glu Lys
110 115 120GGG GCG TTT GGA TAC AAC GGA GGG CCC ATG TAT TAC ATC AAA AAC GGT 436Gly Ala Phe Gly Tyr Asn Gly Gly Pro Met Tyr Tyr Ile Lys Asn Gly
125 130 135CTT AAC ATG CCC AAA CTC GCC ATG GCG TTT GCG ATT TTT ACG ATT ATT 484Leu Asn Met Pro Lys Leu Ala Met Ala Phe Ala Ile Phe Thr Ile Ile
140 145 150GCA AGC ATT GGC ACC GGT AAC ATG ACG CAA TCT AAT GCG GTT TCT TCC 532Ala Ser Ile Gly Thr Gly Asn Met Thr Gln Ser Asn Ala Val Ser Ser155 160 165 170ATT TTA AGC GAA CAA GCG AAC CTG CCT AAT TGG GTT TCA GGT TTA TTG 580Ile Leu Ser Glu Gln Ala Asn Leu Pro Asn Trp Val Ser Gly Leu Leu
175 180 185CTC ACT CTT TTA ACC GCT TTC ATT GTC ATA GGG GGG ATC AAA TCC ATT 628Leu Thr Leu Leu Thr Ala Phe Ile Val Ile Gly Gly Ile Lys Ser Ile
190 195 200GGT AAA TTC ACT TCT TAC TTA GCT CCT GTT ATG GTG CTT TTA TAT TTG 676Gly Lys Phe Thr Ser Tyr Leu Ala Pro Val Met Val Leu Leu Tyr Leu
205 210 215ATC GCT ATT ATT TAT ATT ATT GTT AGC CAT TTT GAT TTA GCC CTT CAA 724Ile Ala Ile Ile Tyr Ile Ile Val Ser His Phe Asp Leu Ala Leu Gln
220 225 230GCG ATC AAA CTC ATT TTT GAA GAA GCC TTT AAC CCT AAA CCC GTT GTG 772Ala Ile Lys Leu Ile Phe Glu Glu Ala Phe Asn Pro Lys Pro Val Val235 240 245 250GGC GGA GCG AGC GGC GCG TTG ATA GCG ACGATG ATA AAA ACG GGC GTG 820Gly Gly Ala Ser Gly Ala Leu Ile Ala Thr Met Ile Lys Thr Gly Val
255 260 265GCT AGG GGG TTG TAT TCT AAT GAA GCG GGG TTA GGG AGC TCA GCC ATT 868Ala Arg Gly Leu Tyr Ser Asn Glu Ala Gly Leu Gly Ser Ser Ala Ile
270 275 280ATT GCC GCG AGC GCT CAA ACA CGC CAC CCG GTG CGC CAA GCC TTA GTG 916Ile Ala Ala Ser Ala Gln Thr Arg His Pro Val Arg Gln Ala Leu Val
285 290 295TCC ATG CTC CAA ACT TTT ATT GTA ACC TTA ATA GTG TGT TCG GCA ACA 964Ser Met Leu Gln Thr Phe Ile Val Thr Leu Ile Val Cys Ser Ala Thr
300 305 310GCG AGC GTG ATT TTA ATG GCT CCA GAA TAC AAC ACC TTG CTC CCT AAT 1012Ala Ser Val Ile Leu Met Ala Pro Glu Tyr Asn Thr Leu Leu Pro Asn315 320 325 330GGG GAA AAA TTA AGC GCT AAT TTG CTC ACT CTA AAA AGC ACG GAG TAT 1060Gly Glu Lys Leu Ser Ala Asn Leu Leu Thr Leu Lys Ser Thr Glu Tyr
335 340 345TTT CTA GGC TCA TTA GGG ACG GTG GTG ATT TTT ACA ACC ATG ATC TTT 1108Phe Leu Gly Ser Leu Gly Thr Val Val Ile Phe Thr Thr Met Ile Phe
350 355 360TTT GCC TAC TCT ACG ATC ATT GGT TGG GCT TAT TAT GGG GAA AAA TGC 1156Phe Ala Tyr Ser Thr Ile Ile Gly Trp Ala Tyr Tyr Gly Glu Lys Cys
365 370 375ACT GAA TAC GCC TTT GGT GAA AAA AAA GTG AAA TAT TAC CGC TTG ATC 1204Thr Glu Tyr Ala Phe Gly Glu Lys Lys Val Lys Tyr Tyr Arg Leu Ile
380 385 390TTT TTA GCG AGT GTG ATG GTG GGG GCT ATG GCC AAA ATT GAT TTT GTG 1252Phe Leu Ala Ser Val Met Val Gly Ala Met Ala Lys Ile Asp Phe Val395 400 405 410TGG AAT TTA GCG GAT CTT TCT AAC GGG CTT ATG GCT ATC CCT AAT TTA 1300Trp Asn Leu Ala Asp Leu Ser Asn Gly Leu Met Ala Ile Pro Asn Leu
415 420 425ATC GCT TTG ATT TTA TTG CAT AAA GTG GTT TAT TCT GAA ACT CGT TGG 1348Ile Ala Leu Ile Leu Leu His Lys Val Val Tyr Ser Glu Thr Arg Trp
430 435 440TAT TTT AGC AAG CAT TCT AAC AAG TAAAATGGCA TGTTAAAAAG GGCGAGTTTT 1402Tyr Phe Ser Lys His Ser Asn Lys
445450 GTAGAAGTGG ATACCGCTTC T1423 (2) sequence 908 data: (i) sequence characteristics: length (A): 450 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 908: met Glu Thr Ile Asp Ser Val Val Arg Leu Leu Ser Asn Leu Val Trp 151015 Gly Ile Pro Met Gln Ile Leu Leu Val Gly Thr Gly Leu Phe Leu Thr
20 25 30Phe Tyr Leu Arg Gly Leu Gln Phe Ser Lys Ile Phe Tyr Ala Ile Lys
35 40 45Ile Leu Phe Asp Lys Glu Ser Gln Ser Lys Gly Asp Ile Ser Gln Phe
50 55 60Ser Ala Leu Met Leu Ser Leu Gly Ala Thr Val Gly Ile Gly Ser Ile65 70 75 80Val Gly Val Ala Thr Ala Ile Ser Ile Ala Gly Pro Gly Ala Val Phe
85 90 95Trp Met Trp Val Thr Gly Leu Val Gly Met Ala Thr Lys Tyr Ser Glu
100 105 110Gly Ile Leu Ala Val Lys Tyr Arg Glu Lys Gly Ala Phe Gly Tyr Asn
115 120125Gly Gly Pro Met Tyr Tyr Ile Lys Asn Gly Leu Asn Met Pro Lys Leu
130 135 140Ala Met Ala Phe Ala Ile Phe Thr Ile Ile Ala Ser Ile Gly Thr Gly145 150 155 160Asn Met Thr Gln Ser Asn Ala Val Ser Ser Ile Leu Ser Glu Gln Ala
165 170 175Asn Leu Pro Asn Trp Val Ser Gly Leu Leu Leu Thr Leu Leu Thr Ala
180 185 190Phe Ile Val Ile Gly Gly Ile Lys Ser Ile Gly Lys Phe Thr Ser Tyr
195 200 205Leu Ala Pro Val Met Val Leu Leu Tyr Leu Ile Ala Ile Ile Tyr Ile
210 215 220Ile Val Ser His Phe Asp Leu Ala Leu Gln Ala Ile Lys Leu Ile Phe225 230 235 240Glu Glu Ala Phe Asn Pro Lys Pro Val Val Gly Gly Ala Ser Gly Ala
245 250 255Leu Ile Ala Thr Met Ile Lys Thr Gly Val Ala Arg Gly Leu Tyr Ser
260 265 270Asn Glu Ala Gly Leu Gly Ser Ser Ala Ile Ile Ala Ala Ser Ala Gln
275 280 285Thr Arg His Pro Val Arg Gln Ala Leu Val Ser Met Leu Gln Thr Phe
290 295 300Ile Val Thr Leu Ile Val Cys Ser Ala Thr Ala Ser Val Ile Leu Met305 310 315 320Ala Pro Glu Tyr Asn Thr Leu Leu Pro Asn Gly Glu Lys Leu Ser Ala
325 330 335Asn Leu Leu Thr Leu Lys Ser Thr Glu Tyr Phe Leu Gly Ser Leu Gly
340 345350Thr Val Val Ile Phe Thr Thr Met Ile Phe Phe Ala Tyr Ser Thr Ile
355 360 365Ile Gly Trp Ala Tyr Tyr Gly Glu Lys Cys Thr Glu Tyr Ala Phe Gly
370 375 380Glu Lys Lys Val Lys Tyr Tyr Arg Leu Ile Phe Leu Ala Ser Val Met385 390 395 400Val Gly Ala Met Ala Lys Ile Asp Phe Val Trp Asn Leu Ala Asp Leu
405 410 415Ser Asn Gly Leu Met Ala Ile Pro Asn Leu Ile Ala Leu Ile Leu Leu
420 425 430His Lys Val Val Tyr Ser Glu Thr Arg Trp Tyr Phe Ser Lys His Ser
435 440 445Asn Lys
450 (2) sequence 909 data: (i) sequence characteristics: length (A): 367 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 333 (D) other information: (xi) Description of the sequence: sequence 909: TTTAAATTAA GCCCGAAATG GAATTTTAAA GGGGCTTGGT TTTTGAGC ATG AGC TTC 57
Met Ser Phe
1AGG GTG TCT AAC ACC ACA CCA GGG CAT GAG AGT GGG GCT TTT TTA AAC 105Arg Val Ser Asn Thr Thr Pro Gly His Glu Ser Gly Ala Phe Leu Asn
5 10 15GCA GAA ATA AGC CCA GCA TTC CCA AAA GAA GTG CCG TTT GCG CCA TCG 153Ala Glu Ile Ser Pro Ala Phe Pro Lys Glu Val Pro Phe Ala Pro Ser20 25 30 35TTT TTT TCT ATC ACG CAG ACC TTA TGC CCT AAC TTG TGC ATA GAA TAC 201Phe Phe Ser Ile Thr GlnThr Leu Cys Pro Asn Leu Cys Ile Glu Tyr
40 45 50GCA CAA GAA AGC CCT ACA ATC CCA CCG CCT ATG ACC ACG ACC TCT TTT 249Ala Gln Glu Ser Pro Thr Ile Pro Pro Pro Met Thr Thr Thr Ser Phe
55 60 65TTC ATG CTG ATA GTC CCT TTA ATA AAT TAC TTA ATG GCT ATC GCT TCA 297Phe Met Leu Ile Val Pro Leu Ile Asn Tyr Leu Met Ala Ile Ala Ser
70 75 80ATT TCT ACT AAA GCG TCT TTA GGC AGT TTA GCC ACT TGAAAGGTCG CTCTGG 349Ile Ser Thr Lys Ala Ser Leu Gly Ser Leu Ala Thr
859095 CCGGATAAGG CTCTGTAA 367 (367) (2) sequence 910 data: (i) sequence characteristics: length (A): 95 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 910: met Ser Phe Arg Val Ser Asn Thr Thr Pro Gly His Glu Ser Gly Ala 151015 Phe Leu Asn Ala Glu Ile Ser Pro Ala Phe Pro Lys Glu Val Pro Phe
20 25 30Ala Pro Ser Phe Phe Ser Ile Thr Gln Thr Leu Cys Pro Asn Leu Cys
35 40 45Ile Glu Tyr Ala Gln Glu Ser Pro Thr Ile Pro Pro Pro Met Thr Thr
50 55 60Thr Ser Phe Phe Met Leu Ile Val Pro Leu Ile Asn Tyr Leu Met Ala65 70 75 80Ile Ala Ser Ile Ser Thr Lys Ala Ser Leu Gly Ser Leu Ala Thr
859095 (2) sequence 911 data: (i) sequence characteristics: length (A): 756 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 689 (D) other information: (xi) Description of the sequence: sequence 911: GCGCACGCTG AATTTAGGGT TTTGAAAGGT TAAAA ATG AAA TTT AAA TTT TTG 53
Met Lys Phe Lys Phe Leu
1 5AAT ATG GAT AAT GAA AGC GGT TTT ATT TTG ATT GAA AAA GAA TTG AAA 101Asn Met Asp Asn Glu Ser Gly Phe Ile Leu Ile Glu Lys Glu Leu Lys
10 15 20CGA TTA AAC ATT CTC GCT CAA GTC AAA GAA GAT TGC ATT GAA TTA AAA 149Arg Leu Asn Ile Leu Ala Gln Val Lys Glu Asp Cys Ile Glu Leu Lys
25 30 35GGC GAA AAC ACA GAA CAA GCG AGA ATT TAT CTT AAA ACG CTT TTT AAC 197Gly Glu Asn Thr Glu Gln Ala Arg Ile Tyr Leu Lys Thr Leu Phe Asn
40 45 50TCC AAT ATT GTA GAA TTA GAC GAT CAT CAA AAA AGT GCA AAC GCT TTA 245Ser Asn Ile Val Glu Leu Asp Asp His Gln Lys Ser Ala Asn Ala Leu55 60 65 70ATA GAG CGC TTG AAA TCT TTA GAT TTA AAA ATT GCG GTG GCT GAA AGC 293Ile Glu Arg Leu Lys Ser Leu Asp Leu Lys Ile Ala Val Ala Glu Ser
75 80 85TGC TCT GGG GGG CTA TTA TCG CAT GCA TTC ACT TCC ATT AGC GGG GCT 341Cys Ser Gly Gly Leu Leu Ser His Ala Phe Thr Ser Ile Ser Gly Ala
90 95 100TCA GCG GTT TTT ATG GGG GGT ATT GTG TGC TAC AAT GAA GAG GTT AAG 389Ser Ala Val Phe Met Gly Gly Ile Val Cys Tyr Asn Glu Glu Val Lys
105 110 115CGC GAA TTA TTG AAG GTC AAT GCC ACG ACT TTA AAA GTC TTT GGG GTT 437Arg Glu Leu Leu Lys Val Asn Ala Thr Thr Leu Lys Val Phe Gly Val
120 125 130TAT AGC GAAGAA TGC GTG AAA GAA ATG CTA CTA GGC GTG TTT TTG AAT 485Tyr Ser Glu Glu Cys Val Lys Glu Met Leu Leu Gly Val Phe Leu Asn135 140 145 150TTT AAA GTG GAT TTA GCG CTT GCG ATG AGT GGG GTG GCT GGC CCT AAT 533Phe Lys Val Asp Leu Ala Leu Ala Met Ser Gly Val Ala Gly Pro Asn
155 160 165GGG GGG AAC AAG GCT AAT CCT GTA GGC ACG ATT TAC ATT GGC GCG CAA 581Gly Gly Asn Lys Ala Asn Pro Val Gly Thr Ile Tyr Ile Gly Ala Gln
170 175 180AAG TTA GGA TCT CAA GCT TTA ATC GAT CGC TGT TTT TTT GAA GGG AAC 629Lys Leu Gly Ser Gln Ala Leu Ile Asp Arg Cys Phe Phe Glu Gly Asn
185 190 195AGA GAA AGC ATT CAA AAT AAA AGC GTA GAG CAT GCC TTA AAC ATG CTC 677Arg Glu Ser Ile Gln Asn Lys Ser Val Glu His Ala Leu Asn Met Leu
200205210 GCT AGA ATG CTA TAAAACTACC TTAACGCACA AACGCTACCA AATTCTTTTT GAGCG 734Ala Arg Met Leu215 ACCTTAGCGGA TGTAAGCGAT TT 756 (2) sequence 912 data: (i) sequence characteristics: length (A): 218 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 912: met Lys Phe Lys Phe Leu Asn Met Asp Asn Glu Ser Gly Phe Ile Leu 151015 Ile Glu Lys Glu Leu Lys Arg Leu Asn Ile Leu Ala Gln Val Lys Glu
20 25 30Asp Cys Ile Glu Leu Lys Gly Glu Asn Thr Glu Gln Ala Arg Ile Tyr
35 40 45Leu Lys Thr Leu Phe Asn Ser Asn Ile Val Glu Leu Asp Asp His Gln
50 55 60Lys Ser Ala Asn Ala Leu Ile Glu Arg Leu Lys Ser Leu Asp Leu Lys65 70 75 80Ile Ala Val Ala Glu Ser Cys Ser Gly Gly Leu Leu Ser His Ala Phe
85 90 95Thr Ser Ile Ser Gly Ala Ser Ala Val Phe Met Gly Gly Ile Val Cys
100 105 110Tyr Asn Glu Glu Val Lys Arg Glu Leu Leu Lys Val Asn Ala Thr Thr
115 120 125Leu Lys Val Phe Gly Val Tyr Ser Glu Glu Cys Val Lys Glu Met Leu
130 135 140Leu Gly Val Phe Leu Asn Phe Lys Val Asp Leu Ala Leu Ala Met Ser145 150 155 160Gly Val Ala Gly Pro Asn Gly Gly Asn Lys Ala Asn Pro Val Gly Thr
165 170 175Ile Tyr Ile Gly Ala Gln Lys Leu Gly Ser Gln Ala Leu Ile Asp Arg
180 185 190Cys Phe Phe Glu Gly Asn Arg Glu Ser Ile Gln Asn Lys Ser Val Glu
195 200 205His Ala Leu Asn Met Leu Ala Arg Met Leu
210215 (2) sequence 913 data: (i) sequence characteristics: length (A): 681 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 657 (D) other information: (xi) Description of the sequence: sequence 913: AAATTCTAAA AAAATAAAGG AAAATCA ATG AAA TTT TTG GAT CAA GAA AAA AGA 54
Met Lys Phe Leu Asp Gln Glu Lys Arg
1 5AGA CAA TTA TTA AAC GAG CGC CAT TCT TGC AAG ATG TTT GAT AGC CAT 102Arg Gln Leu Leu Asn Glu Arg His Ser Cys Lys Met Phe Asp Ser His10 15 20 25TAT GAG TTT TCT AGC ACA GAA TTA GAA GAA ATC GCT GAA ATC GCC AGG 150Tyr Glu Phe Ser Ser Thr Glu Leu Glu Glu Ile Ala Glu Ile Ala Arg
30 35 40CTA TCG CCA AGC TCT TAC AAC ACG CAG CCA TGG CAT TTT GTG ATG GTT 198Leu Ser Pro Ser Ser Tyr Asn Thr Gln Pro Trp His Phe Val Met Val
45 50 55ACT GAT AAG GAT TTA AAA AAA CAA ATT GCA GCG CAC AGC TAT TTC AAT 246Thr Asp Lys Asp Leu Lys Lys Gln Ile Ala Ala His Ser Tyr Phe Asn
60 65 70GAA GAG ATG ATT AAA AGC GCT TCA GCG TTA ATG GTG GTA TGC TCT TTA 294Glu Glu Met Ile Lys Ser Ala Ser Ala Leu Met Val Val Cys Ser Leu
75 80 85AGA CCC AGC GAG TTG TTA CCA CAC GGC CAC TAC ATG CAA AAT CTC TAT 342Arg Pro Ser Glu Leu Leu Pro His Gly His Tyr Met Gln Asn Leu Tyr90 95 100 105CCG GAG TCT TAT AAA GTT AGA GTG ATC CCC TCT TTT GCT CAA ATG CTT 390Pro Glu Ser Tyr Lys Val Arg Val Ile Pro Ser Phe Ala Gln Met Leu
110 115 120GGC GTG AGA TTC AAC CAC AGC ATG CAA AGA TTA GAA AGC TAT ATT TTA 438Gly Val Arg Phe Asn His Ser Met Gln Arg Leu Glu Ser Tyr Ile Leu
125 130 135Glu Gln Cys Tyr Ile Ala Val Gly Gln Ile Cys Met Gly Val Ser Leu
140 145 150ATG GGA TTG GAT AGT TGC ATT ATT GGA GGC TTT GAT CCT TTA AAG GTG 534Met Gly Leu Asp Ser Cys Ile Ile Gly Gly Phe Asp Pro Leu Lys Val
155 160 165GGC GAA GTT TTA GAA GAG CGT ATC AAT AAG CCT AAA ATC GCA TGC TTG 582Gly Glu Val Leu Glu Glu Arg Ile Asn Lys Pro Lys Ile Ala Cys Leu170175 180 185ATC GCT TTG GGC AAG AGG GTG GCA GAA GCG AGT CAA AAA TCA AGA AAA 630Ile Ala Leu Gly Lys Arg Val Ala Glu Ala Ser Gln Lys Ser Arg Lys
190 195 200TCA AAA GTT GAT GCG ATT ACT TGG TTG TGATTAAACA AAATCAAAAA CTTT 681Ser Lys Val Asp Ala Ile Thr Trp Leu
205210 (2) sequence 914 data: (i) sequence characteristics: length (A): 210 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 914: met Lys Phe Leu Asp Gln Glu Lys Arg Arg Gln Leu Leu Asn Glu Arg 151015 His Ser Cys Lys Met Phe Asp Ser His Tyr Glu Phe Ser Ser Thr Glu
20 25 30Leu Glu Glu Ile Ala Glu Ile Ala Arg Leu Ser Pro Ser Ser Tyr Asn
35 40 45Thr Gln Pro Trp His Phe Val Met Val Thr Asp Lys Asp Leu Lys Lys
50 55 60Gln Ile Ala Ala His Ser Tyr Phe Asn Glu Glu Met Ile Lys Ser Ala65 70 75 80Ser Ala Leu Met Val Val Cys Ser Leu Arg Pro Ser Glu Leu Leu Pro
85 90 95His Gly His Tyr Met Gln Asn Leu Tyr Pro Glu Ser Tyr Lys Val Arg
100 105 110Val Ile Pro Ser Phe Ala Gln Met Leu Gly Val Arg Phe Asn His Ser
115 120 125Met Gln Arg Leu Glu Ser Tyr Ile Leu Glu Gln Cys Tyr Ile Ala Val
130 135 140Gly Gln Ile Cys Met Gly Val Ser Leu Met Gly Leu Asp Ser Cys Ile145 150 155 160Ile GlyGly Phe Asp Pro Leu Lys Val Gly Glu Val Leu Glu Glu Arg
165 170 175Ile Asn Lys Pro Lys Ile Ala Cys Leu Ile Ala Leu Gly Lys Arg Val
180 185 190Ala Glu Ala Ser Gln Lys Ser Arg Lys Ser Lys Val Asp Ala Ile Thr
195 200 205Trp Leu
210 (2) sequence 915 data: (i) sequence characteristics: length (A): 1490 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 99...1439 (D) other information: (xi) Description of the sequence: sequence 915: CTTAAAGAAA ACATGCAAAA TTTGCAAAAT CAAGTTCAAA ACAAAGAGCA ATCCATCGCT 60CAATTAGATG CACAAATCCA AGCTTTAAAG GGGATTCA ATG AGC GTT AAT TTT TTT 116
Met Ser Val Asn Phe Phe
1 5AAG GGC ATT TTT AAT GAC AAT AGC AGG GCT GAA AAC CAC CAA GAC AAC 164Lys Gly Ile Phe Asn Asp Asn Ser Arg Ala Glu Asn His Gln Asp Asn
10 15 20CAC CAA AAC AAC CAT CAA GTG GGC TTA AAA GAG CGT TAC GAT TTG ATC 212His Gln Asn Asn His Gln Val Gly Leu Lys Glu Arg Tyr Asp Leu Ile
25 30 35GCT CGT ATT TTA AAC GCC AGA ATT GAA AAT GAA GGG CTA GAA GAA TAT 260Ala Arg Ile Leu Asn Ala Arg Ile Glu Asn Glu Gly Leu Glu Glu Tyr
40 45 50CAG AGC GTC TTG GAT AAC GAG TTT TTA GAG TTC GCT AGC GGC GTG GAT 308Gln Ser Val Leu Asp Asn Glu Phe Leu Glu Phe Ala Ser Gly Val Asp55 60 65 70TCG CTC AAAGAA AAG GAA ATA GCG TTA CTG ACG CTC CAA GAA ATC CAA 356Ser Leu Lys Glu Lys Glu Ile Ala Leu Leu Thr Leu Gln Glu Ile Gln
75 80 85AAA GAA TTG CAA TTG GTA GCG AGC TAC CCT AGT TTG TTC CAA AAA ACC 404Lys Glu Leu Gln Leu Val Ala Ser Tyr Pro Ser Leu Phe Gln Lys Thr
90 95 100ATC GTT GCG GTG GGG GGA GGG TTT AGC GCG GGC AAA TCC ACT TTT TTA 452Ile Val Ala Val Gly Gly Gly Phe Ser Ala Gly Lys Ser Thr Phe Leu
105 110 115AAC AAC TTG TTG GGC TTG AAA TTA AAA CTC CCT GAA GAC ATG AAT CCC 500Asn Asn Leu Leu Gly Leu Lys Leu Lys Leu Pro Glu Asp Met Asn Pro
120 125 130ACC ACA GCT ATC CCC ACT TAT TGC TTA AAG GGT AAA AGA GAA GTT TTA 548Thr Thr Ala Ile Pro Thr Tyr Cys Leu Lys Gly Lys Arg Glu Val Leu135 140 145 150ATG GGG TTT TCT CAA AAT GGG GGC ATG GTG GAA TTG CCA CAT CTC GCT 596Met Gly Phe Ser Gln Asn Gly Gly Met Val Glu Leu Pro His Leu Ala
155 160 165TTT GAC CAT CAG TTT TTA AAC TCC CTT GGC TTT AAT TTG AAA GAG ATC 644Phe Asp His Gln Phe Leu Asn Ser Leu Gly Phe Asn Leu Lys Glu Ile
170 175 180ATG CCT TTC ATG CTT TTA AGC GCT CCT AGC GTG CCT TTT GAA TTT TTA 692Met Pro Phe Met Leu Leu Ser Ala Pro Ser Val Pro Phe Glu Phe Leu
185 190 195TGC TTC ATA GAC ACG CCT GGT TTT AAC TCC GCC AAG CAA GGC TAT ACG 740Cys Phe Ile Asp Thr Pro Gly Phe Asn Ser Ala Lys Gln Gly Tyr Thr
200 205 210GGT GGG GAT AAA GAA GCC TCT AAA GAA TCC CTA AAA CAC GCC AAA CAC 788Gly Gly Asp Lys Glu Ala Ser Lys Glu Ser Leu Lys His Ala Lys His215 220 225 230ATT CTG TGG CTC ATT AGT TGC GAG AGT GGG GAG ATT CAC GAA GAT GAT 836Ile Leu Trp Leu Ile Ser Cys Glu Ser Gly Glu Ile His Glu Asp Asp
235 240 245TTA GAA TAT TTG CAA GAA TTA TAC GAA GAA GGC AAG CAG GTT TTT ATC 884Leu Glu Tyr Leu Gln Glu Leu Tyr Glu Glu Gly Lys Gln Val Phe Ile
250 255 260GTA TTG AGT AGG GCT GAT AGG CGC ACA AAA AGG CAA TTA GAA GAA GTC 932Val Leu Ser Arg Ala Asp Arg Arg Thr Lys Arg Gln Leu Glu Glu Val
265 270 275GTT ATT AAA ATT AAA GAG ACT TTA AAA GAT AAT GGC ATT GAA TTT TTA 980Val Ile Lys Ile Lys Glu Thr Leu Lys Asp Asn Gly Ile Glu Phe Leu
280 285 290GGG ATT GGT GCT TAT AGT TCT ACA AGG TAT CAA GAA TAT AAA GAA TTC 1028Gly Ile Gly Ala Tyr Ser Ser Thr Arg Tyr Gln Glu Tyr Lys Glu Phe295 300 305 310AGC GAA AAA AGC AAA GTT TTT AAC TCG CTT GAG GAA TTT CTA ATG AAG 1076Ser Glu Lys Ser Lys Val Phe Asn Ser Leu Glu Glu Phe Leu Met Lys
315 320 325TTA AAT CAA AGG AGC GAG AAA CAA AAC GAA ATT TTA GGA TAT TTA TAC 1124Leu Asn Gln Arg Ser Glu Lys Gln Asn Glu Ile Leu Gly Tyr Leu Tyr
330 335 340GAG GTG CAT TCC ATG TAT GAA AAG GCT ATT GAG CAA GAC GCT AAC CAA 1172Glu Val His Ser Met Tyr Glu Lys Ala Ile Glu Gln Asp Ala Asn Gln
345 350 355TTC AAA CGC TAC CAA AGC GAA TTG CAT TCT GTT AGA TTG GAT TTG ATG 1220Phe Lys Arg Tyr Gln Ser Glu Leu His Ser Val Arg Leu Asp Leu Met
360 365 370CAA AAA GGC TTT GAT GAT TTT AGC GAT AAA ATT TTT AGA AGA ATT GAG 1268Gln Lys Gly Phe Asp Asp Phe Ser Asp Lys Ile Phe Arg Arg Ile Glu375 380 385 390AAT TTA GAA AAA GAA TTT TCC GAG CAA GAG CGA TCC AAA AGA GAG AGT 1316Asn Leu Glu Lys Glu Phe Ser Glu Gln Glu Arg Ser Lys Arg Glu Ser
395 400 405TTA GCG CGA TTG AAT GAA GTG ATT GAC TTG TTT AAA GAA GGT ATT GAT 1364Leu Ala Arg Leu Asn Glu Val Ile Asp Leu Phe Lys Glu Gly Ile Asp
410 415 420AAG GTT TTT GAT CGC GTG AGC GCT TTC ACT TGG GAA AAA TAC AAA GAA 1412Lys Val Phe Asp Arg Val Ser Ala Phe Thr Trp Glu Lys Tyr Lys Glu
425 430 435CAA AAT GAC GAT GAA GAG GAC GAT GAT TGAAGAAAAC TACAAAGAAG AGCGTTA 1466Gln Asn Asp Asp Glu Glu Asp Asp Asp
440445 CACCGAAAGG GTGAATCAAG GCGG 1490 (2) sequence 916 data: (i) sequence characteristics: length (A): 447 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 916: met Ser Val Asn Phe Phe Lys Gly Ile Phe Asn Asp Asn Ser Arg Ala 151015 Glu Asn His Gln Asp Asn His Gln Asn Asn His Gln Val Gly Leu Lys
20 25 30Glu Arg Tyr Asp Leu Ile Ala Arg Ile Leu Asn Ala Arg Ile Glu Asn
35 40 45Glu Gly Leu Glu Glu Tyr Gln Ser Val Leu Asp Asn Glu Phe Leu Glu
50 55 60Phe Ala Ser Gly Val Asp Ser Leu Lys Glu Lys Glu Ile Ala Leu Leu65 70 75 80Thr Leu Gln Glu Ile Gln Lys Glu Leu Gln Leu Val Ala Ser Tyr Pro
85 90 95Ser Leu Phe Gln Lys Thr Ile Val Ala Val Gly Gly Gly Phe Ser Ala
100 105 110Gly Lys Ser Thr Phe Leu Asn Asn Leu Leu Gly Leu Lys Leu Lys Leu
115 120 125Pro Glu Asp Met Asn Pro Thr Thr Ala Ile Pro Thr Tyr Cys Leu Lys
130 135 140Gly Lys Arg Glu Val Leu Met Gly Phe Ser Gln Asn Gly Gly Met Val145 150 155 160Glu Leu Pro His Leu Ala Phe Asp His Gln Phe Leu Asn Ser Leu Gly
165 170 175Phe Asn Leu Lys Glu Ile Met Pro Phe Met Leu Leu Ser Ala Pro Ser
180 185 190Val Pro Phe Glu Phe Leu Cys Phe Ile Asp Thr Pro Gly Phe Asn Ser
195 200 205Ala Lys Gln Gly Tyr Thr Gly Gly Asp Lys Glu Ala Ser Lys Glu Ser
210 215 220Leu Lys His Ala Lys His Ile Leu Trp Leu Ile Ser Cys Glu Ser Gly225 230 235 240Glu Ile His Glu Asp Asp Leu Glu Tyr Leu Gln Glu Leu Tyr Glu Glu
245 250 255Gly Lys Gln Val Phe Ile Val Leu Ser Arg Ala Asp Arg Arg Thr Lys
260 265 270Arg Gln Leu Glu Glu Val Val Ile Lys Ile Lys Glu Thr Leu Lys Asp
275 280 285Asn Gly Ile Glu Phe Leu Gly Ile Gly Ala Tyr Ser Ser Thr Arg Tyr
290 295 300Gln Glu Tyr Lys Glu Phe Ser Glu Lys Ser Lys Val Phe Asn Ser Leu305 310 315 320Glu Glu Phe Leu Met Lys Leu Asn Gln Arg Ser Glu Lys Gln Asn Glu
325 330 335Ile Leu Gly Tyr Leu Tyr Glu Val His Ser Met Tyr Glu Lys Ala Ile
340 345 350Glu Gln Asp Ala Asn Gln Phe Lys Arg Tyr Gln Ser Glu Leu His Ser
355 360 365Val Arg Leu Asp Leu Met Gln Lys Gly Phe Asp Asp Phe Ser Asp Lys
370 375 380Ile Phe Arg Arg Ile Glu Asn Leu Glu Lys Glu Phe Ser Glu Gln Glu385 390 395 400Arg Ser Lys Arg Glu Sar Leu Ala Arg Leu Asn Glu Val Ile Asp Leu
405 410 415Phe Lys Glu Gly Ile Asp Lys Val Phe Asp Arg Val Ser Ala Phe Thr
420 425 430Trp Glu Lys Tyr Lys Glu Gln Asn Asp Asp Glu Glu Asp Asp Asp
435440445 (2) data of sequence 917: (i) sequence characteristics: length (A): 1718 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1674 (D) other information: (xi) Description of the sequence: sequence 917: ATTTTAGTTT TTAATTTTAA AGGATTG ATG ATG GTT TTA CGC ACA CAG ACA AAT 54
Met Met Val Leu Arg Thr Gln Thr Asn
1 5TTT GTG GAG TTT TTA GAA CAG GTT TTA GAA GTT TTA AAA GAA GTG GAG 102Phe Val Glu Phe Leu Glu Gln Val Leu Glu Val Leu Lys Glu Val Glu10 15 20 25ATC GAT AAA ACA GAATGC TCC ACG CTT TTA GCA AGC GTT CAA AAA CAA 150Ile Asp Lys Thr Glu Cys Ser Thr Leu Leu Ala Ser Val Gln Lys Gln
30 35 40CAG CTA GTG ATA CCC GTT GTG GGG AAT TTT AGC GCA GGG AAA AGC ACG 198Gln Leu Val Ile Pro Val Val Gly Asn Phe Ser Ala Gly Lys Ser Thr
45 50 55CTA TTA AAC CGC TTT TTA GGC AGC AGC GTT TTG CCT ACC GGT ATC ACG 246Leu Leu Asn Arg Phe Leu Gly Ser Ser Val Leu Pro Thr Gly Ile Thr
60 65 70CCA GAG ACT TCT TTA GCC ACT GAG TTG CAC TAT AGC GCT AAG GAA CGC 294Pro Glu Thr Ser Leu Ala Thr Glu Leu His Tyr Ser Ala Lys Glu Arg
75 80 85ATA GAG GCT TTT TCA AAC AAT GAT GAA AAA ACA GAG AGT TTT GAA CTG 342Ile Glu Ala Phe Ser Asn Asn Asp Glu Lys Thr Glu Ser Phe Glu Leu90 95 100 105AAT GAG CAA AGT TTT GAA GCG ATT AAA GAG AAT GCC ACG AAG TAT TCC 390Asn Glu Gln Ser Phe Glu Ala Ile Lys Glu Asn Ala Thr Lys Tyr Ser
110 115 120TAC CTT AAG GTT TAT TTG AAT AAT GAA GCT TTG AAA AAC AGC GCT CCT 438Tyr Leu Lys Val Tyr Leu Asn Asn Glu Ala Leu Lys Asn Ser Ala Pro
125 130 135TTA GTG TTT GTG GAT ATG CCA GGC TTT GAT AGC CCC ATT TCA AGC CAC 486Leu Val Phe Val Asp Met Pro Gly Phe Asp Ser Pro Ile Ser Ser His
140 145 150ACC CAT GCC ATT TTG GAA TAT TTA GAA AGG GGC GTG CAT TTT GTC ATT 534Thr His Ala Ile Leu Glu Tyr Leu Glu Arg Gly Val His Phe Val Ile
155 160 165CTC ACA AGC GTA GAA GAG GGC AAT CTC ACT AAA CGC ATG GTT AGG GAG 582Leu Thr Ser Val Glu Glu Gly Asn Leu Thr Lys Arg Met Val Arg Glu170 175 180 185TTA AAA AAC CTT TTA GAG TTT GAC AAA GGC CTT AGC TTT ATT TTG AGT 630Leu Lys Asn Leu Leu Glu Phe Asp Lys Gly Leu Ser Phe Ile Leu Ser
190 195 200AAA ACG AAT TTA AGA ACG CCT TCG CAA GTG GGA GAA ATC TCT CAC TAC 678Lys Thr Asn Leu Arg Thr Pro Ser Gln Val Gly Glu Ile Ser His Tyr
205 210 215ATT CAA GAT CAA ATC CAG GAT CAC CTT GAT TTG ACA ACG CAC CTC ATC 726Ile Gln Asp Gln Ile Gln Asp His Leu Asp Leu Thr Thr His Leu Ile
220 225 230CAT TCC AAT AAA GAC AAT AAC GCC CTT TTA GAG GTA GCG GAT AAA ATA 774His Ser Asn Lys Asp Asn Asn Ala Leu Leu Glu Val Ala Asp Lys Ile
235 240 245GAC GCT GAA AAG CTT TTT AGC GCT TTG TAT TTG AAA CGA TTG AAG TTT 822Asp Ala Glu Lys Leu Phe Ser Ala Leu Tyr Leu Lys Arg Leu Lys Phe250 255 260 265TTA AAT TCT AAG TTA CAA AAT AGC CTA AAA AGC GTG ATG GAA AGC TTT 870Leu Asn Ser Lys Leu Gln Asn Ser Leu Lys Ser Val Met Glu Ser Phe
270 275 280GAT TAT TCT AAA GAA AAG GCT TTA GAA GAA ATA CAA GCT TTG GAT TTG 918Asp Tyr Ser Lys Glu Lys Ala Leu Glu Glu Ile Gln Ala Leu Asp Leu
285 290 295GGC GTT AAA GAC ATT GAA AAA ACC TAT GAA AAA TTA AGG GCT AAT TTA 966Gly Val Lys Asp Ile Glu Lys Thr Tyr Glu Lys Leu Arg Ala Asn Leu
300 305 310GAA GAA GAA TAT TCT AGC GTG GCT GTG GGA TCG GTG GTT AAA AAA GTA 1014Glu Glu Glu Tyr Ser Ser Val Ala Val Gly Ser Val Val Lys Lys Val
315 320 325GTA GAA GAG GTT AGG GAT CAA AAA TCC TAT TTA GCC TCT TTA ATC AAC 1062Val Glu Glu Val Arg Asp Gln Lys Ser Tyr Leu Ala Ser Leu Ile Asn330 335 340 345AAG CCT AAC GAG TTC AAT AGC GAA ATA GAA AGC ATC ATG CAA CAA AGC 1110Lys Pro Asn Glu Phe Asn Ser Glu Ile Glu Ser Ile Met Gln Gln Ser
350 355 360TTG ATC AAA AAC GCT AAA TTA GAG ATT GAA AAG ATC AAC CTT TCT TTT 1158Leu Ile Lys Asn Ala Lys Leu Glu Ile Glu Lys Ile Asn Leu Ser Phe
365 370 375TCA AAA GAT TTC CAT GCG GAA TTT GAA AGC CTG AAC AAG CTT TCT AGC 1206Ser Lys Asp Phe His Ala Glu Phe Glu Ser Leu Asn Lys Leu Ser Ser
380 385 390GAT CTG TCT GTG AAT TTA GAG CAT GGG ATT GAA TTA GGG ATC AAC GCT 1254Asp Leu Ser Val Asn Leu Glu His Gly Ile Glu Leu Gly Ile Asn Ala
395 400 405TTA AGC GTG ATT TTT TCC AAG AAT CCG GTT ACA AGG CCA TTC GCG CTG 1302Leu Ser Val Ile Phe Ser Lys Asn Pro Val Thr Arg Pro Phe Ala Leu410 415 420 425ATT TTG CAA GGG TTA AAA TCT CTT TTA AAA GAT TTA CTG ACA TTG TTG 1350Ile Leu Gln Gly Leu Lys Ser Leu Leu Lys Asp Leu Leu Thr Leu Leu
430 435 440CCT AAT ATC ATC GCT TCA TTC TTT AGG AAT GAA GAA AAA GAG CGG GCG 1398Pro Asn Ile Ile Ala Ser Phe Phe Arg Asn Glu Glu Lys Glu Arg Ala
445 450 455AAA TTA GAA AAT CTG ATT GAA GTC AGA GTG ATT CCA GAA ATC CAA TAC 1446Lys Leu Glu Asn Leu Ile Glu Val Arg Val Ile Pro Glu Ile Gln Tyr
460 465 470AAG CTTAAA AAA GTT TTA CCG GGA TTG TTT AAT GAA GCT TTG CAA AAT 1494Lys Leu Lys Lys Val Leu Pro Gly Leu Phe Asn Glu Ala Leu Gln Asn
475 480 485TCC CTA AAA TCT CTA AAA GAT CGG TGC GAG CTA GAA ATC ACG CAT AAA 1542Ser Leu Lys Ser Leu Lys Asp Arg Cys Glu Leu Glu Ile Thr His Lys490 495 500 505AAA CAA GAA ATC GCG CTC GCT CAA AAG GAA AAA GAA AAA CAC CTA AAC 1590Lys Gln Glu Ile Ala Leu Ala Gln Lys Glu Lys Glu Lys His Leu Asn
510 515 520GAT TTA GAA GAT CAA AAA CAA ATC TTA GAA AAT AAG ATC AAC GCT TTA 1638Asp Leu Glu Asp Gln Lys Gln Ile Leu Glu Asn Lys Ile Asn Ala Leu
525 530 535AGC GAT TTA GAA CAA CAA TAT TTA AAG GAT CAA CAA TGAACGAGCA AGAACT 1690Ser Asp Leu Glu Gln Gln Tyr Leu Lys Asp Gln Gln
540545 CATTCAAAAA AGCGCTTTAA TTGAAAAA 1718 (2) sequence 918 data: (i) sequence characteristics: length (A): 549 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 918: met Met Val Leu Arg Thr Gln Thr Asn Phe Val Glu Phe Leu Glu Gln 151015 Val Leu Glu Val Leu Lys Glu Val Glu Ile Asp Lys Thr Glu Cys Ser
20 25 30Thr Leu Leu Ala Ser Val Gln Lys Gln Gln Leu Val Ile Pro Val Val
35 40 45Gly Asn Phe Ser Ala Gly Lys Ser Thr Leu Leu Asn Arg Phe Leu Gly
50 55 60Ser Ser Val Leu Pro Thr Gly Ile Thr Pro Glu Thr Ser Leu Ala Thr65 70 75 80Glu Leu His Tyr Ser Ala Lys Glu Arg Ile Glu Ala Phe Ser Asn Asn
8590 95Asp Glu Lys Thr Glu Ser Phe Glu Leu Asn Glu Gln Ser Phe Glu Ala
100 105 110Ile Lys Glu Asn Ala Thr Lys Tyr Ser Tyr Leu Lys Val Tyr Leu Asn
115 120 125Asn Glu Ala Leu Lys Asn Ser Ala Pro Leu Val Phe Val Asp Met Pro
130 135 140Gly Phe Asp Ser Pro Ile Ser Ser His Thr His Ala Ile Leu Glu Tyr145 150 155 160Leu Glu Arg Gly Val His Phe Val Ile Leu Thr Ser Val Glu Glu Gly
165 170 175Asn Leu Thr Lys Arg Met Val Arg Glu Leu Lys Asn Leu Leu Glu Phe
180 185 190Asp Lys Gly Leu Ser Phe Ile Leu Ser Lys Thr Asn Leu Arg Thr Pro
195 200 205Ser Gln Val Gly Glu Ile Ser His Tyr Ile Gln Asp Gln Ile Gln Asp
210 215 220His Leu Asp Leu Thr Thr His Leu Ile His Ser Asn Lys Asp Asn Asn225 230 235 240Ala Leu Leu Glu Val Ala Asp Lys Ile Asp Ala Glu Lys Leu Phe Ser
245 250 255Ala Leu Tyr Leu Lys Arg Leu Lys Phe Leu Asn Ser Lys Leu Gln Asn
260 265 270Ser Leu Lys Ser Val Met Glu Ser Phe Asp Tyr Ser Lys Glu Lys Ala
275 280 285Leu Glu Glu Ile Gln Ala Leu Asp Leu Gly Val Lys Asp Ile Glu Lys
290 295 300Thr Tyr Glu Lys Leu Arg Ala Asn Leu Glu Glu Glu Tyr Ser Ser Val305 310 315320Ala Val Gly Ser Val Val Lys Lys Val Val Glu Glu Val Arg Asp Gln
325 330 335Lys Ser Tyr Leu Ala Ser Leu Ile Asn Lys Pro Asn Glu Phe Asn Ser
340 345 350Glu Ile Glu Ser Ile Met Gln Gln Ser Leu Ile Lys Asn Ala Lys Leu
355 360 365Glu Ile Glu Lys Ile Asn Leu Ser Phe Ser Lys Asp Phe His Ala Glu
370 375 380Phe Glu Ser Leu Asn Lys Leu Ser Ser Asp Leu Ser Val Asn Leu Glu385 390 395 400His Gly Ile Glu Leu Gly Ile Asn Ala Leu Ser Val Ile Phe Ser Lys
405 410 415Asn Pro Val Thr Arg Pro Phe Ala Leu Ile Leu Gln Gly Leu Lys Ser
420 425 430Leu Leu Lys Asp Leu Leu Thr Leu Leu Pro Asn Ile Ile Ala Ser Phe
435 440 445Phe Arg Asn Glu Glu Lys Glu Arg Ala Lys Leu Glu Asn Leu Ile Glu
450 455 460Val Arg Val Ile Pro Glu Ile Gln Tyr Lys Leu Lys Lys Val Leu Pro465 470 475 480Gly Leu Phe Asn Glu Ala Leu Gln Asn Ser Leu Lys Ser Leu Lys Asp
485 490 495Arg Cys Glu Leu Glu Ile Thr His Lys Lys Gln Glu Ile Ala Leu Ala
500 505 510Gln Lys Glu Lys Glu Lys His Leu Asn Asp Leu Glu Asp Gln Lys Gln
515 520 525Ile Leu Glu Asn Lys Ile Asn Ala Leu Ser Asp Leu Glu Gln Gln Tyr
530535540 Leu Lys Asp Gln Gln545 (2) sequence 919 data: (i) sequence characteristics: length (A): 360 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 348 (D) other information: (xi) Description of the sequence: sequence 919: TCTTTTTCTT CATTCCTAAA GAATGAAGCG ATG ATA TTA GGC AAC AAT GTC AGT 54
Met Ile Leu Gly Asn Asn Val Ser
1 5AAA TCT TTT AAA AGA GAT TTT AAC CCT TGC AAA ATC AGC GCG AAT GGC 102Lys Ser Phe Lys Arg Asp Phe Asn Pro Cys Lys Ile Ser Ala Asn Gly
10 15 20CTT GTA ACC GGA TTC TTG GAA AAA ATC ACG CTT AAA GCG TTG ATC CCT 150Leu Val Thr Gly Phe Leu Glu Lys Ile Thr Leu Lys Ala Leu Ile Pro25 30 35 40AAT TCA ATC CCA TGC TCT AAA TTC ACA GAC AGA TCG CTA GAA AGC TTG 198Asn Ser Ile Pro Cys Ser Lys Phe Thr Asp Arg Ser Leu Glu Ser Leu
45 50 55TTC AGG CTT TCA AAT TCC GCA TGG AAA TCT TTT GAA AAA GAA AGG TTG 246Phe Arg Leu Ser Asn Ser Ala Trp Lys Ser Phe Glu Lys Glu Arg Leu
60 65 70ATC TTT TCA ATC TCT AAT TTA GCG TTT TTG ATC AAG CTT TGT TGC ATG 294Ile Phe Ser Ile Ser Asn Leu Ala Phe Leu Ile Lys Leu Cys Cys Met
75 80 85ATG CTT TCT ATT TCG CTA TTG AAC TCG TTA GGC TTG TTG ATT AAA GAG 342Met Leu Ser Ile Ser Leu Leu Asn Ser Leu Gly Leu Leu Ile Lys Glu
9095100 GCT AAA TAGGATTTTT GA 360Ala Lys105 (2) sequence 920 data: (i) sequence characteristics: length (A): 106 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 920: met Ile Leu Gly Asn Asn Val Ser Lys Ser Phe Lys Arg Asp Phe Asn 151015 Pro Cys Lys Ile Ser Ala Asn Gly Leu Val Thr Gly Phe Leu Glu Lys
20 25 30Ile Thr Leu Lys Ala Leu Ile Pro Asn Ser Ile Pro Cys Ser Lys Phe
35 40 45Thr Asp Arg Ser Leu Glu Ser Leu Phe Arg Leu Ser Asn Ser Ala Trp
50 55 60Lys Ser Phe Glu Lys Glu Arg Leu Ile Phe Ser Ile Ser Asn Leu Ala65 70 75 80Phe Leu Ile Lys Leu Cys Cys Met Met Leu Ser Ile Ser Leu Leu Asn
85 90 95Ser Leu Gly Leu Leu Ile Lys Glu Ala Lys
100105 (2) sequence 921 data: (i) sequence characteristics: length (A): 3179 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 61...3120 (D) other information: (xi) Description of the sequence: sequence 921: CAGCGTGGCA GTGGGGTCAT TGATAGGGTT AAAAGGCATG ATCAACAATT TAGGGGAGGA 60ATG ATG CTC GCT TCC ATT ATT GAA TTT TCC TTA CGC CAA AGA GTG ATC 108Met Met Leu Ala Ser Ile Ile Glu Phe Ser Leu Arg Gln Arg Val Ile 151015 GTG ATT GTT GGT GCG ATT CTT ATT TTA TTT TTT GGG ACT TAT AGT TTT 156Val Ile Val Gly Ala Ile Leu Ile Leu Phe Phe Gly Thr Tyr Ser Phe
20 25 30ATC AAC ACT CCA GTG GAC GCT TTC CCG GAT ATT TCG CCC ACT CAA GTT 204Ile Asn Thr Pro Val Asp Ala Phe Pro Asp Ile Ser Pro Thr Gln Val
35 40 45AAA ATC ATT TTA AAA CTC CCC GGC TCT AGC CCT GAA GAA ATG GAA AAC 252Lys Ile Ile Leu Lys Leu Pro Gly Ser Ser Pro Glu Glu Met Glu Asn
50 55 60AAC ATC GTG CGC CCT TTA GAA TTG GAG CTT TTA GGC TTG AAA GGG CAA 300Asn Ile Val Arg Pro Leu Glu Leu Glu Leu Leu Gly Leu Lys Gly Gln65 70 75 80AAA TCT TTA AGG AGT GTT TCA AAA TAT TCT ATT TCA GAT ATT ACG ATA 348Lys Ser Leu Arg Ser Val Ser Lys Tyr Ser Ile Ser Asp Ile Thr Ile
85 90 95GAT TTT GAT GAC AGC GTG GAT ATT TAT TTA GCG AGG AAT ATT GTC AAT 396Asp Phe Asp Asp Ser Val Asp Ile Tyr Leu Ala Arg Asn Ile Val Asn
100 105 110GAG CGC TTG AGC AGC GTG ATG AAA GAT TTA CCC GTG GGG GTT GAG GGG 444Glu Arg Leu Ser Ser Val Met Lys Asp Leu Pro Val Gly Val Glu Gly
115 120 125GGC ATG GCG CCC ATT GTT ACG CCG CTA TCA GAT ATC TTT ATG TTC ACT 492Gly Met Ala Pro Ile Val Thr Pro Leu Ser Asp Ile Phe Met Phe Thr
130 135 140ATT GAT GGC AAT ATC ACT GAG ATA GAA AAA CGA CAG CTT TTA GAT TTT 540Ile Asp Gly Asn Ile Thr Glu Ile Glu Lys Arg Gln Leu Leu Asp Phe145 150 155 160GTG ATC CGC CCA CAA TTA AGA ATG ATT AGC GGC GTA GCA GAT GTC AAT 588Val Ile Arg Pro Gln Leu Arg Met Ile Ser Gly Val Ala Asp Val Asn
165 170 175TCC ATT GGA GGC TTT AGC AGA GCG TTT GTG ATC GTG CCG GAT TTT AAT 636Ser Ile Gly Gly Phe Ser Arg Ala Phe Val Ile Val Pro Asp Phe Asn
180 185 190GAC ATG GCA AGG CTT GGG GTG AGT ATT TCT GAT TTA GAA TCG GCT GTG 684Asp Met Ala Arg Leu Gly Val Ser Ile Ser Asp Leu Glu Ser Ala Val
195 200 205AGA GTG AAT TTA AGA AAC AGC GGA GCG GGG CGC GTG GAT AGA GAT GGC 732Arg Val Asn Leu Arg Asn Ser Gly Ala Gly Arg Val Asp Arg Asp Gly
210 215 220GAA ACC TTT TTA GTC AAA ATC CAA ACC GCT TCT TTG AGT TTA GAA GAC 780Glu Thr Phe Leu Val Lys Ile Gln Thr Ala Ser Leu Ser Leu Glu Asp225 230 235 240ATT GGC AAA ATC ACC GTT TCC ACT AAT TTA GGG CAT TTG CAC ATT AAG 828Ile Gly Lys Ile Thr Val Ser Thr Asn Leu Gly His Leu His Ile Lys
245 250 255GAT TTT GCG AAA GTC ATC AGC CAG TCT CGC ACC CGT TTG GGG TTT GTT 876Asp Phe Ala Lys Val Ile Ser Gln Ser Arg Thr Arg Leu Gly Phe Val
260 265 270ACT AAA GAT GGC GTG GGC GAG ACC ACA GAA GGC TTG GTG CTT TCT TTA 924Thr Lys Asp Gly Val Gly Glu Thr Thr Glu Gly Leu Val Leu Ser Leu
275 280 285AAA GAC GCT AAC ACC AAA GAA ATC ATC ACT CAA GTG TAT CAA AAA CTA 972Lys Asp Ala Asn Thr Lys Glu Ile Ile Thr Gln Val Tyr Gln Lys Leu
290 295 300GAA GAA TTA AAA CCC TTT TTA CCG AAT GGC GTG TCC ATT AAT GTT TTT 1020Glu Glu Leu Lys Pro Phe Leu Pro Asn Gly Val Ser Ile Asn Val Phe305 310 315 320TAT GAT CGC TCA GAA TTT ACG CAA AAA GCC ATT GCC ACC GTT TCT AAA 1068Tyr Asp Arg Ser Glu Phe Thr Gln Lys Ala Ile Ala Thr Val Ser Lys
325 330 335ACC CTC ATT GAA GCC GTT GTT TTA ATC ATC ATC ACG CTC TTT TTA TTT 1116Thr Leu Ile Glu Ala Val Val Leu Ile Ile Ile Thr Leu Phe Leu Phe
340 345 350TTA GGG AAT TTG AGG GCG AGC GTG GCT GTG GGG GTG ATT TTA CCT TTA 1164Leu Gly Asn Leu Arg Ala Ser Val Ala Val Gly Val Ile Leu Pro Leu
355 360 365AGC TTG TCC GTG GCG TTT ATT TTT ATC AAG TTT AGC GAT CTG ACT TTA 1212Ser Leu Ser Val Ala Phe Ile Phe Ile Lys Phe Ser Asp Leu Thr Leu
370 375 380AAT TTG ATG AGT TTA GGG GGA TTG GTT ATC GCT ATA GGC ATG CTC ATT 1260Asn Leu Met Ser Leu Gly Gly Leu Val Ile Ala Ile Gly Met Leu Ile385 390 395 400GAC TCA GCC GTG GTG GTG GTG GAA AAC GCT TTT GAA AAA TTA AGC GCT 1308Asp Ser Ala Val Val Val Val Glu Asn Ala Phe Glu Lys Leu Ser Ala
405 410 415AAC ACT AAA ACC ACT AAA CTC CAT GCA ATC TAT CGT TCG TGT AAA GAA 1356Asn Thr Lys Thr Thr Lys Leu His Ala Ile Tyr Arg Ser Cys Lys Glu
420 425 430ATC GCT GTT TCA GTG GTG AGC GGG GTG GTG ATC ATC ATT GTG TTT TTT 1404Ile Ala Val Ser Val Val Ser Gly Val Val Ile Ile Ile Val Phe Phe
435 440 445GTG CCG ATT TTA ACC TTA CAG GGG TTA GAG GGT AAG ATG TTT AGG CCT 1452Val Pro Ile Leu Thr Leu Gln Gly Leu Glu Gly Lys Met Phe Arg Pro
450 455 460TTA GCG CAA AGC ATT GTG TAT GCG CTT TTA GGC ACT TTA GTT CTA TCT 1500Leu Ala Gln Ser Ile Val Tyr Ala Leu Leu Gly Thr Leu Val Leu Ser465 470 475 480ATT ACA ATC ATT CCT GTA GTC AGC TCT CTT GTC TTA AAA GCC ACG CCC 1548Ile Thr Ile Ile Pro Val Val Ser Ser Leu Val Leu Lys Ala Thr Pro
485 490 495CAT AGC GAA ACC TTT TTA ACG AGG TTT TTA AAC AGA ATC TAC GCC CCT 1596His Ser Glu Thr Phe Leu ThrArg Phe Leu Asn Arg Ile Tyr Ala Pro
500 505 510TTA TTG GAA TTT TTT GTG CAT AAC CCT AAA AAA GTG ATT TTA GGA GCG 1644Leu Leu Glu Phe Phe Val His Asn Pro Lys Lys Val Ile Leu Gly Ala
515 520 525TTT GTT TTT TTA ATC GCA AGC CTT TCT TTA TTC CCT TTT GTG GGG AAG 1692Phe Val Phe Leu Ile Ala Ser Leu Ser Leu Phe Pro Phe Val Gly Lys
530 535 540AAT TTC ATG CCC GTT TTA GAT GAG GGC GAT GTG GTT TTG AGC GTG GAA 1740Asn Phe Met Pro Val Leu Asp Glu Gly Asp Val Val Leu Ser Val Glu545 550 555 560ACC ACC CCT TCT ATT TCT TTA GAT CAA TCT AGG GAT CTC ATG CTA AAC 1788Thr Thr Pro Ser Ile Ser Leu Asp Gln Ser Arg Asp Leu Met Leu Asn
565 570 575ATT GAG AGC GCG ATT AAA AAG CAT GTC AAG GAA GTT AAA AGC ATT GTC 1836Ile Glu Ser Ala Ile Lys Lys His Val Lys Glu Val Lys Ser Ile Val
580 585 590GCG CGC ACA GGG AGC GAT GAA TTG GGG CTG GAT TTA GGA GGT TTG AAT 1884Ala Arg Thr Gly Ser Asp Glu Leu Gly Leu Asp Leu Gly Gly Leu Asn
595 600 605CAA ACC GAT ACT TTT ATT TCT TTT ATT CCT AAA AAA GAA TGG AGC GTT 1932Gln Thr Asp Thr Phe Ile Ser Phe Ile Pro Lys Lys Glu Trp Ser Val
610 615 620AAA ACC AAA GAT GAA TTA TTA GAA AAA ATC ATG GAT TCT TTA AAA GAC 1980Lys Thr Lys Asp Glu Leu Leu Glu Lys Ile Met Asp Ser Leu Lys Asp625 630 635 640TTT AAG GGG ATT AAC TTT TCT TTC ACC CAA CCC ATT GAA ATG AGA ATT 2028Phe Lys Gly Ile Asn Phe Ser Phe Thr Gln Pro Ile Glu Met Arg Ile
645 650 655TCT GAA ATG CTG ACA GGG GTT AGG GGG GAT TTA GCG GTT AAG ATT TTT 2076Ser Glu Met Leu Thr Gly Val Arg Gly Asp Leu Ala Val Lys Ile Phe
660 665 670GGA GAT GGT ATT AGC GAA TTG AAT GAA TTG AGT TTT CAA ATC GCG CAA 2124Gly Asp Gly Ile Ser Glu Leu Asn Glu Leu Ser Phe Gln Ile Ala Gln
675 680 685GCT CTA AAA GGG ATT AAA GGA TCT AGT GAA GTT TTA ACC ACG CTT AAT 2172Ala Leu Lys Gly Ile Lys Gly Ser Ser Glu Val Leu Thr Thr Leu Asn
690 695 700GAG GGC GTG AAT TAT TTG TAT GTA ACC CCT AAT AAA GAA TCG ATG GCG 2220Glu Gly Val Asn Tyr Leu Tyr Val Thr Pro Asn Lys Glu Ser Met Ala705 710 715 720GAT GTG GGG ATC ACT AGC GAT GAA TTT TCC AAG TTT TTA AAA TCC GCT 2268Asp Val Gly Ile Thr Ser Asp Glu Phe Ser Lys Phe Leu Lys Ser Ala
725 730 735TTA GAG GGC TTG GTT GTA GAT GTG ATC CCT ACA GGG ATT TCA CGC ACG 2316Leu Glu Gly Leu Val Val Asp Val Ile Pro Thr Gly Ile Ser Arg Thr
740 745 750CCA GTG ATG ATC CGC CAA GAG AGC GAT TTT GCA AGC TCT ATC ACT AAA 2364Pro Val Met Ile Arg Gln Glu Ser Asp Phe Ala Ser Ser Ile Thr Lys
755 760 765ATC AAA AGT TTA GCC TTG ACT TCA AAA TAT GGC GTT TTA GTG CCT ATC 2412Ile Lys Ser Leu Ala Leu Thr Ser Lys Tyr Gly Val Leu Val Pro Ile
770 775 780ACT TCT ATC GCC AAA ATT GAA GAA GTG GAT GGC CCT GTT TCT GTT GTG 2460Thr Ser Ile Ala Lys Ile Glu Glu Val Asp Gly Pro Val Ser Val Val785 790 795 800CGT GAA AAT TCA ATG CGC ATG AGC GTG GTT CGC AGT AAT GTG GTG GGG 2508Arg Glu Asn Ser Met Arg Met Ser Val Val Arg Ser Asn Val Val Gly
805 810 815CGC GAT TTG AAA TCT TTT GTA GAA GAG GCT AAA AAA GTG ATC GCT CAA 2556Arg Asp Leu Lys Ser Phe Val Glu Glu Ala Lys Lys Val Ile Ala Gln
820 825 830AAC ATC AAA CTC CCT CCC AGC TAC TAT ATC ACT TAT GGG GGG CAG TTT 2604Asn Ile Lys Leu Pro Pro Ser Tyr Tyr Ile Thr Tyr Gly Gly Gln Phe
835 840 845GAA AAC CAG CAA CGG GCC AAT AAA AGG CTC TCC ACC GTT ATC CCT TTA 2652Glu Asn Gln Gln Arg Ala Asn Lys Arg Leu Ser Thr Val Ile Pro Leu
850 855 860AGC ATC TTA GCG ATT TTT TTC ATT CTT TTT TTC ACT TTT AAA AGC ATT 2700Ser Ile Leu Ala Ile Phe Phe Ile Leu Phe Phe Thr Phe Lys Ser Ile865 870 875 880CCT TTA GCC TTG CTC ATT CTT TTG AAT ATC CCT TTT GCG GTT ACC GGA 2748Pro Leu Ala Leu Leu Ile Leu Leu Asn Ile Pro Phe Ala Val Thr Gly
885 890 895GGC CTT ATT GCG TTG TTT GCG GTC GGG GAG TAT ATT TCA GTG CCA GCG 2796Gly Leu Ile Ala Leu Phe Ala Val Gly Glu Tyr Ile Ser Val Pro Ala
900 905 910AGC GTG GGC TTT ATC GCT CTT TTT GGG ATT GCG GTT TTA AAT GGC GTG 2844Ser Val Gly Phe Ile Ala Leu Phe Gly Ile Ala Val Leu Asn Gly Val
915 920 925GTG ATG ATA GGC TAT TTT AAA GAG CTT CTC TTG CAA GGG AAA AGC GTA 2892Val Met Ile Gly Tyr Phe Lys Glu Leu Leu Leu Gln Gly Lys Ser Val
930 935 940GAA GAA TGC GTT TTA TTG GGC GCT AAA AGG CGT TTG AGA CCG GTT TTA 2940Glu Glu Cys Val Leu Leu Gly Ala Lys Arg Arg Leu Arg Pro Val Leu945 950 955 960ATG ACC GCT TGC ATT GCC GGT TTG GGT TTG CTC CCT TTA TTA TTT TCT 2988Met Thr Ala Cys Ile Ala Gly Leu Gly Leu Leu Pro Leu Leu Phe Ser
965 970 975CAT AGC GTG GGA TCA GAA GTC CAA AAA CCT TTA GCG ATC GTG GTG CTT 3036His Ser Val Gly Ser Glu Val Gln Lys Pro Leu Ala Ile Val Val Leu
980 985 990GGA GGC TTG GTT ACC TCA AGC GCT CTA ACC TTA CTC CTA CTG CCG CCA 3084Gly Gly Leu Val Thr Ser Ser Ala Leu Thr Leu Leu Leu Leu Pro Pro
995 1000 1005ATG TTT ATG CTC ATC GCT AAA AAG ATT AAA ATC GTT TGAGTTAAAG GATTTC 3136Met Phe Met Leu Ile Ala Lys Lys Ile Lys Ile Val
101010151020 ACATGCTCGC TTTAGAAATT TATATTGATA TTTGTTTGAA AGA 3179 (2) sequence 922 data: (i) sequence characteristics: length (A): 1020 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 922: met Met Leu Ala Ser Ile Ile Glu Phe Ser Leu Arg Gln Arg Val Ile 151015 Val Ile Val Gly Ala Ile Leu Ile Leu Phe Phe Gly Thr Tyr Ser Phe
20 25 30Ile Asn Thr Pro Val Asp Ala Phe Pro Asp Ile Ser Pro Thr Gln Val
35 40 45Lys Ile Ile Leu Lys Leu Pro Gly Ser Ser Pro Glu Glu Met Glu Asn
50 55 60Asn Ile Val Arg Pro Leu Glu Leu Glu Leu Leu Gly Leu Lys Gly Gln65 70 75 80Lys Ser Leu Arg Ser Val Ser Lys Tyr Ser Ile Ser Asp Ile Thr Ile
85 90 95Asp Phe Asp Asp Ser Val AspIle Tyr Leu Ala Arg Asn Ile Val Asn
100 105 110Glu Arg Leu Ser Ser Val Met Lys Asp Leu Pro Val Gly Val Glu Gly
115 120 125Gly Met Ala Pro Ile Val Thr Pro Leu Ser Asp Ile Phe Met Phe Thr
130 135 140Ile Asp Gly Asn Ile Thr Glu Ile Glu Lys Arg Gln Leu Leu Asp Phe145 150 155 160Mal Ile Arg Pro Gln Leu Arg Met Ile Ser Gly Val Ala Asp Val Asn
165 170 175Ser Ile Gly Gly Phe Ser Arg Ala Phe Val Ile Val Pro Asp Phe Asn
180 185 190Asp Met Ala Arg Leu Gly Val Ser Ile Ser Asp Leu Glu Ser Ala Val
195 200 205Arg Val Asn Leu Arg Asn Ser Gly Ala Gly Arg Val Asp Arg Asp Gly
210 215 220Glu Thr Phe Leu Val Lys Ile Gln Thr Ala Ser Leu Ser Leu Glu Asp225 230 235 240Ile Gly Lys Ile Thr Val Ser Thr Asn Leu Gly His Leu His Ile Lys
245 250 255Asp Phe Ala Lys Val Ile Ser Gln Ser Arg Thr Arg Leu Gly Phe Val
260 265 270Thr Lys Asp Gly Val Gly Glu Thr Thr Glu Gly Leu Val Leu Ser Leu
275 280 285Lys Asp Ala Asn Thr Lys Glu Ile Ile Thr Gln Val Tyr Gln Lys Leu
290 295 300Glu Glu Leu Lys Pro Phe Leu Pro Asn Gly Val Ser Ile Asn Val Phe305 310 315 320Tyr Asp Arg Ser Glu Phe Thr Gln Lys Ala Ile Ala Thr ValSer Lys
325 330 335Thr Leu Ile Glu Ala Val Val Leu Ile Ile Ile Thr Leu Phe Leu Phe
340 345 350Leu Gly Asn Leu Arg Ala Ser Val Ala Val Gly Val Ile Leu Pro Leu
355 360 365Ser Leu Ser Val Ala Phe Ile Phe Ile Lys Phe Ser Asp Leu Thr Leu
370 375 380Asn Leu Met Ser Leu Gly Gly Leu Val Ile Ala Ile Gly Met Leu Ile385 390 395 400Asp Ser Ala Val Val Val Val Glu Asn Ala Phe Glu Lys Leu Ser Ala
405 410 415Asn Thr Lys Thr Thr Lys Leu His Ala Ile Tyr Arg Ser Cys Lys Glu
420 425 430Ile Ala Val Ser Val Val Ser Gly Val Val Ile Ile Ile Val Phe Phe
435 440 445Val Pro Ile Leu Thr Leu Gln Gly Leu Glu Gly Lys Met Phe Arg Pro
450 455 460Leu Ala Gln Ser Ile Val Tyr Ala Leu Leu Gly Thr Leu Val Leu Ser465 470 475 480Ile Thr Ile Ile Pro Val Val Ser Ser Leu Val Leu Lys Ala Thr Pro
485 490 495His Ser Glu Thr Phe Leu Thr Arg Phe Leu Asn Arg Ile Tyr Ala Pro
500 505 510Leu Leu Glu Phe Phe Val His Asn Pro Lys Lys Val Ile Leu Gly Ala
515 520 525Phe Val Phe Leu Ile Ala Ser Leu Ser Leu Phe Pro Phe Val Gly Lys
530 535 540Asn Phe Met Pro Val Leu Asp Glu Gly Asp Val Val Leu Ser Val Glu545 550 555 560Thr Thr Pro Ser Ile Ser Leu Asp Gln Ser Arg Asp Leu Met Leu Asn
565 570 575Ile Glu Ser Ala Ile Lys Lys His Val Lys Glu Val Lys Ser Ile Val
580 585 590Ala Arg Thr Gly Ser Asp Glu Leu Gly Leu Asp Leu Gly Gly Leu Asn
595 600 605Gln Thr Asp Thr Phe Ile Ser Phe Ile Pro Lys Lys Glu Trp Ser Val
610 615 620Lys Thr Lys Asp Glu Leu Leu Glu Lys Ile Met Asp Ser Leu Lys Asp625 630 635 640Phe Lys Gly Ile Asn Phe Ser Phe Thr Gln Pro Ile Glu Met Arg Ile
645 650 655Ser Glu Met Leu Thr Gly Val Arg Gly Asp Leu Ala Val Lys Ile Phe
660 665 670Gly Asp Gly Ile Ser Glu Leu Asn Glu Leu Ser Phe Gln Ile Ala Gln
675 680 685Ala Leu Lys Gly Ile Lys Gly Ser Ser Glu Val Leu Thr Thr Leu Asn
690 695 700Glu Gly Val Asn Tyr Leu Tyr Val Thr Pro Asn Lys Glu Ser Met Ala705 710 715 720Asp Val Gly Ile Thr Ser Asp Glu Phe Ser Lys Phe Leu Lys Ser Ala
725 730 735Leu Glu Gly Leu Val Val Asp Val Ile Pro Thr Gly Ile Ser Arg Thr
740 745 750Pro Val Met Ile Arg Gln Glu Ser Asp Phe Ala Ser Ser Ile Thr Lys
755 760 765Ile Lys Ser Leu Ala Leu Thr Ser Lys Tyr Gly Val Leu Val Pro Ile
770 775 780Thr Ser Ile Ala Lys Ile Glu Glu Val Asp Gly Pro Val Ser Val Val785 790 795 800Arg Glu Asn Ser Met Arg Met Ser Val Val Arg Ser Asn Val Val Gly
805 810 815Arg Asp Leu Lys Ser Phe Val Glu Glu Ala Lys Lys Val Ile Ala Gln
820 825 830Asn Ile Lys Leu Pro Pro Ser Tyr Tyr Ile Thr Tyr Gly Gly Gln Phe
835 840 845Glu Asn Gln Gln Arg Ala Asn Lys Arg Leu Ser Thr Val Ile Pro Leu
850 855 860Ser Ile Leu Ala Ile Phe Phe Ile Leu Phe Phe Thr Phe Lys Ser Ile865 870 875 880Pro Leu Ala Leu Leu Ile Leu Leu Asn Ile Pro Phe Ala Val Thr Gly
885 890 895Gly Leu Ile Ala Leu Phe Ala Val Gly Glu Tyr Ile Ser Val Pro Ala
900 905 910Ser Val Gly Phe Ile Ala Leu Phe Gly Ile Ala Val Leu Asn Gly Val
915 920 925Val Met Ile Gly Tyr Phe Lys Glu Leu Leu Leu Gln Gly Lys Ser Val
930 935 940Glu Glu Cys Val Leu Leu Gly Ala Lys Arg Arg Leu Arg Pro Val Leu945 950 955 960Met Thr Ala Cys Ile Ala Gly Leu Gly Leu Leu Pro Leu Leu Phe Ser
965 970 975His Ser Val Gly Ser Glu Val Gln Lys Pro Leu Ala Ile Val Val Leu
980 985 990Gly Gly Leu Val Thr SerSer Ala Leu Thr Leu Leu Leu Leu Pro Pro
995 1000 1005Met Phe Met Leu Ile Ala Lys Lys Ile Lys Ile Val
101010151020 (2) sequence 923 data: (i) sequence characteristics: length (A): 720bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 638 (D) other information: (xi) Description of the sequence: sequence 923: AAGCTTATAA AATCATCAAA AAGAGTGCTG AA ATG AAT GTT TTA ATC AGA TTG 53
Met Asn Val Leu Ile Arg Leu
1 5TGC TTT ATT TTT TTG ATT GGG TTT TTT GGC GCG AAT AAA ACC CTA AAC 101Cys Phe Ile Phe Leu Ile Gly Phe Phe Gly Ala Asn Lys Thr Leu Asn
10 15 20GCA ACA GCC ATT CTT TCT CTT GAC TTT GGC TCT TTT TCC ATG CCA ATC 149Ala Thr Ala Ile Leu Ser Leu Asp Phe Gly Ser Phe Ser Met Pro Ile
25 30 35ACT GCC AAT TTC TCA GAT GGT GCG TTA AAT GTA TTC AAA TGG TTT GAA 197Thr Ala Asn Phe Ser Asp Gly Ala Leu Asn Val Phe Lys Trp Phe Glu40 45 50 55AAA CAC CCA TCA GTG GGT GTT AAA GTT GGT CGG CTT GCA AAT CAA GAC 245Lys His Pro Ser Val Gly Val Lys Val Gly Arg Leu Ala Asn Gln Asp
60 65 70GAC ACT ATC TTT ACT CTA GTT TTC ATT GTG ATA GTT GTC GCA ATA ATT 293Asp Thr Ile Phe Thr Leu Val Phe Ile Val Ile Val Val Ala Ile Ile
75 80 85GCC CTT ATC GCT ATT TTT ATA AGG AGT ATA TTA CTA AAC ACA ATT TTT 341Ala Leu Ile Ala Ile Phe Ile Arg Ser Ile Leu Leu Asn Thr Ile Phe
90 95 100GTA GGA TCG CTC ATA GGA TCC TTA TGG TTG TAT ATG GTA GGG TTT TAT 389Val Gly Ser Leu Ile Gly Ser Leu Trp Leu Tyr Met Val Gly Phe Tyr
105 110 115TAT TTT TAT GGT GTT CCC TTT TTG AGT TAT TTG AGC GGT TGT TAT GAA 437Tyr Phe Tyr Gly Val Pro Phe Leu Ser Tyr Leu Ser Gly Cys Tyr Glu120 125 130 135TCG TTT TCT TTC TCC GCA TGC TAT CCT CAT AGT TTG CAG CTA CTC CCC 485Ser Phe Ser Phe Ser Ala Cys Tyr Pro His Ser Leu Gln Leu Leu Pro
140 145 150ACC CTT ATG CAG TAT TCG CCC ATT TAC TCC ATA ATC AAA CTT CTT GCT 533Thr Leu Met Gln Tyr Ser Pro Ile Tyr Ser Ile Ile Lys Leu Leu Ala
155 160 165CAT TTT AAT ATA GAG ATC ACT TCT AAG ATT ATC ATT TCT CTT GTT TGG 581His Phe Asn Ile Glu Ile Thr Ser Lys Ile Ile Ile Ser Leu Val Trp
170 175 180GTG TGT ATA GGG CTG TAT TTT TTG TTA TTG CAA GCG TTT TTT AGT CTT 629Val Cys Ile Gly Leu Tyr Phe Leu Leu Leu Gln Ala Phe Phe Ser Leu
185190195 ACA AAT TAT TAGTTGCAGA AAATTCAAGA AGGCAAAAAA TTATCTTTTT TCCTCGAAT 687Thr Asn Tyr200CAATCATTAG GTTATTTTTT GGTTTTATGA TAG 720 (2) sequence 924 data: (i) sequence characteristics: length (A): 202 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 924: met Asn Val Leu Ile Arg Leu Cys Phe Ile Phe Leu Ile Gly Phe Phe 151015 Gly Ala Asn Lys Thr Leu Asn Ala Thr Ala Ile Leu Ser Leu Asp Phe
20 25 30Gly Ser Phe Ser Met Pro Ile Thr Ala Asn Phe Ser Asp Gly Ala Leu
35 40 45Asn Val Phe Lys Trp Phe Glu Lys His Pro Ser Val Gly Val Lys Val
50 55 60Gly Arg Leu Ala Asn Gln Asp Asp Thr Ile Phe Thr Leu Val Phe Ile65 70 75 80Val Ile Val Val Ala Ile Ile Ala Leu Ile Ala Ile Phe Ile Arg Ser
85 90 95Ile Leu Leu Asn Thr Ile Phe Val Gly Ser Leu Ile Gly Ser Leu Trp
100 105 110Leu Tyr Met Val Gly Phe Tyr Tyr Phe Tyr Gly Val Pro Phe Leu Ser
115 120 125Tyr Leu Ser Gly Cys Tyr Glu Ser Phe Ser Phe Ser Ala Cys Tyr Pro
130 135 140His Ser Leu Gln Leu Leu Pro Thr Leu Met Gln Tyr Ser Pro Ile Tyr145 150 155 160Ser Ile Ile Lys Leu Leu Ala His Phe Asn Ile Glu Ile Thr Ser Lys
165 170 175Ile Ile Ile Ser Leu Val Trp Val Cys Ile Gly Leu Tyr Phe Leu Leu
180 185 190Leu Gln Ala Phe Phe Ser Leu Thr Asn Tyr
195200 (2) data of sequence 925: (i) sequence characteristics: length (A): 310bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 65...280 (D) other information: (xi) Description of the sequence: sequence 925: AATTCAAGAA GGCAAAAAAT TATCTTTTTT CCTCGAATCA ATCATTAGGT TATTTTTTGG 60TTTT ATG ATA GTT TCT TTT ATT GCC GTT CCA TGC TAC TAT GTT TTA TTG 109
Met Ile Val Ser Phe Ile Ala Val Pro Cys Tyr Tyr Val Leu Leu
1 5 10 15GCG ATG GAA TAC CAA ATA GCC TAT GAA CAC CCA GGA GAA TTA ATA AGC 157Ala Met Glu Tyr Gln Ile Ala Tyr Glu His Pro Gly Glu Leu Ile Ser
20 25 30ACG ATT GGT TTT GTT GCG TTA GCA GTG CTT GTG TAT TAC TTA TGG GGT 205Thr Ile Gly Phe Val Ala Leu Ala Val Leu Val Tyr Tyr Leu Trp Gly
35 40 45AAA TGG GAG AAG TTG CTA TGG GGC GCA CCT TCC AAT CAA GAG CAA CAA 253Lys Trp Glu Lys Leu Leu Trp Gly Ala Pro Ser Asn Gln Glu Gln Gln
50 55 60CTC TCC AAT CAA GGC AAC CAA AAT CAA TGATTGTGAT TGATCGCTAG GTCAATC 307Leu Ser Asn Gln Gly Asn Gln Asn Gln
6570 TGA 310(2) sequence 926 data: (i) sequence characteristics: length (A): 72 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 926: met Ile Val Ser Phe Ile Ala Val Pro Cys Tyr Tyr Val Leu Leu Ala 151015 Met Glu Tyr Gln Ile Ala Tyr Glu His Pro Gly Glu Leu Ile Ser Thr
20 25 30Ile Gly Phe Val Ala Leu Ala Val Leu Val Tyr Tyr Leu Trp Gly Lys
35 40 45Trp Glu Lys Leu Leu Trp Gly Ala Pro Ser Asn Gln Glu Gln Gln Leu
50 55 60Ser Asn Gln Gly Asn Gln Asn Gln65 70
(2) Data of sequence 927: (i) sequence characteristics: length (A): 311 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 287 (D) other information: (xi) Description of the sequence: sequence 927: TAGGAAAAAG ACTATCATGC GAGCTATCCA AATTAGATCC GATCAAAAAC TACCCTTTA A60
MeTGG TTG TAT CAA TGA ACT GCA TCG GCT CTA AAT ACA AAC TCA TTG CCT 108t Val Val Ser Met Asn Cys Ile Gly Ser Lys Tyr Lys Leu Ile Ala Ph1 5 10 15TTA TTC AAG AAA ATA TCC ATG CGG TTG TGG GGC AAC CTT TTG GGT GTG 156e Ile Gln Glu Asn Ile His Ala Val Val Gly Gln Pro Phe Gly Cys As
20 25 30ATT TTT TGC GAT CTG TTC GCT GGG ACG GGT ATC GTG GGG TGT GCG TAA 204p Phe Leu Arg Ser Val Arg Trp Asp Gly Tyr Arg Gly Val Cys Val Ly
354045 AGT GGT CTC TAG GTT CAA CAC TAA AAA ACA TTT TTT CAT TAG ACA GCG 252s Trp Ser Leu Gly Ser Thr Leu Lys Asn Ile Phe Ser Leu Asp Ser Va 5055606 TGT TAA AAG CCA ATC AAG TTA TCC CTA AAG ATG CT TAACATGTTA AAATAAT 304l Leu Lys Ala Asn Gln Val Ile Pro Lys Asp Ala 57075 CTCATAC 311(2) data of sequence 928: (i) sequence characteristics: length (A): 76 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 928: met Val Val Ser Met Asn Cys Ile Gly Ser Lys Tyr Lys Leu Ile Ala 151015 Phe Ile Gln Glu Asn Ile His Ala Val Val Gly Gln Pro Phe Gly Cys
20 25 30Asp Phe Leu Arg Ser Val Arg Trp Asp Gly Tyr Arg Gly Val Cys Val
35 40 45Lys Trp Ser Leu Gly Ser Thr Leu Lys Asn Ile Phe Ser Leu Asp Ser
505560 Val Leu Lys Ala Asn Gln Val Ile Pro Lys Asp Ala 657075 (2) sequence 929 data: (i) sequence characteristics: length (A): 900bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 872 (D) other information: (xi) Description of the sequence: sequence 929: AAAATTAAGT TGTTTGATCG CTTTTAAACG ATTTTTAAAA GGAAAAATTT ATG GAT 56
Met Asp
1GAA ATT AAA ACG CTG TTA GTG GAT TTT TTT CCG CAG GCA AAG CAT TTT 104Glu Ile Lys Thr Leu Leu Val Asp Phe Phe Pro Gln Ala Lys His Phe
5 10 15GGG ATA ATC TTA ATC AAG GCT ATT GTT GTC TTT TGT ATA GGT TTT TAT 152Gly Ile Ile Leu Ile Lys Ala Ile Val Val Phe Cys Ile Gly Phe Tyr
20 25 30TTT TCA TTT TTC TTA CAA AAA AAA ACC ATG AAA TTT TTA TCC AAA AAG 200Phe Ser Phe Phe Leu Gln Lys Lys Thr Met Lys Phe Leu Ser Lys Lys35 40 45 50GAT GAG ATT TTA GCG AAT TTT GTC GCA CAG GTT ACT TTT ATC TTA ATC 248Asp Glu Ile Leu Ala Asn Phe Val Ala Gln Val Thr Phe Ile Leu Ile
55 60 65CTT ATC ATC ACC ACA ATC ATT GCG CTC AGC ACG CTA GGC GTG CAA ACC 296Leu Ile Ile Thr Thr Ile Ile Ala Leu Ser Thr Leu Gly Val Gln Thr
70 75 80ACC TCT ATT ATC ACT GTT TTA GGA ACG GTA GGG ATT GCT GTG GCG TTG 344Thr Ser Ile Ile Thr Val Leu Gly Thr Val Gly Ile Ala Val Ala Leu
85 90 95GCT TTA AAA GAT TAT CTT TCA AGC ATT GCT GGA GGG ATA ATC CTT ATT 392Ala Leu Lys Asp Tyr Leu Ser Ser Ile Ala Gly Gly Ile Ile Leu Ile
100 105 110ATC TTG CAC CCT TTC AAA AAA GGA GAC ATC ATT GAA ATC TCT GGC CTA 440Ile Leu His Pro Phe Lys Lys Gly Asp Ile Ile Glu Ile Ser Gly Leu115120 125 130GAG GGC AAA GTA GAA GCG CTT AAT TTT TTT AAC ACT TCT TTA CGC TTG 488Glu Gly Lys Val Glu Ala Leu Asn Phe Phe Asn Thr Ser Leu Arg Leu
135 140 145CAT GAC GGA CGC TTG GCG GTT TTA CCC AAT AGA AGT GTC GCT AAT TCT 536His Asp Gly Arg Leu Ala Val Leu Pro Asn Arg Ser Val Ala Asn Ser
150 155 160AAT ATT ATC AAT AGC AAT AAC ACG GCG TGT CGG CGC ATT GAA TGG GTT 584Asn Ile Ile Asn Ser Asn Asn Thr Ala Cys Arg Arg Ile Glu Trp Val
165 170 175TGT GGG GTA GGG TAT GGG AGC GAT ATT GAA CTG GTG CAT AAG ACT ATA 632Cys Gly Val Gly Tyr Gly Ser Asp Ile Glu Leu Val His Lys Thr Ile
180 185 190AAA GAT GTT ATT GAT GCA ATG GAA AAA ATT GAT AAA AAC ATG CCC ACT 680Lys Asp Val Ile Asp Ala Met Glu Lys Ile Asp Lys Asn Met Pro Thr195 200 205 210TTT ATT GGG ATC ACG GAT TTT GGA CAA AGT TCG CTG AAT TTC ACC ATT 728Phe Ile Gly Ile Thr Asp Phe Gly Gln Ser Ser Leu Asn Phe Thr Ile
215 220 225AGG GTT TGG GCA AAG ATT GAA GAC GGA ATC TTT AAT GTG CGC AGC GAA 776Arg Val Trp Ala Lys Ile Glu Asp Gly Ile Phe Asn Val Arg Ser Glu
230 235 240CTC ATT GAA CGC ATC AAA AAC GCC CTA GAC GCT AAC CAC ATT GAA ATC 824Leu Ile Glu Arg Ile Lys Asn Ala Leu Asp Ala Asn His Ile Glu Ile
245 250 255CCT TTC AAC AAG CTA GAT ATT GCT ATT AAA AAT CAA GAC TCT CCT AAA T 873Pro Phe Asn Lys Leu Asp Ile Ala Ile Lys Asn Gln Asp Ser Pro Lys
260 265 270GATTGGTGTG AGATGTATTG ATTGTAG 900
(2) Sequence 930 data: (i) sequence characteristics:
(A) length: 274 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (xi) sequence description: sequence 930: met Asp Glu Ile Lys Thr Leu Leu Val Asp Phe Phe Pro Gln Ala Lys 151015 His Phe Gly Ile Ile Leu Ile Lys Ala Ile Val Val Phe Cys Ile Gly
20 25 30Phe Tyr Phe Ser Phe Phe Leu Gln Lys Lys Thr Met Lys Phe Leu Ser
35 40 45Lys Lys Asp Glu Ile Leu Ala Asn Phe Val Ala Gln Val Thr Phe Ile
50 55 60Leu Ile Leu Ile Ile Thr Thr Ile Ile Ala Leu Ser Thr Leu Gly Val65 70 75 80Gln Thr Thr Ser Ile Ile Thr Val Leu Gly Thr Val Gly Ile Ala Val
85 90 95Ala Leu Ala Leu Lys Asp Tyr Leu Ser Ser Ile Ala Gly Gly Ile Ile
100 105 110Leu Ile Ile Leu His Pro Phe Lys Lys Gly Asp Ile Ile Glu Ile Ser
115 120 125Gly Leu Glu Gly Lys Val Glu Ala Leu Asn Phe Phe Asn Thr Ser Leu
130 135 140Arg Leu His Asp Gly Arg Leu Ala Val Leu Pro Asn Arg Ser Val Ala145 150 155 160Asn Ser Asn Ile Ile Asn Ser Asn Asn Thr Ala Cys Arg Arg Ile Glu
165 170 175Trp Val Cys Gly Val Gly TyrGly Ser Asp Ile Glu Leu Val His Lys
180 185 190Thr Ile Lys Asp Val Ile Asp Ala Met Glu Lys Ile Asp Lys Asn Met
195 200 205Pro Thr Phe Ile Gly Ile Thr Asp Phe Gly Gln Ser Ser Leu Asn Phe
210 215 220Thr Ile Arg Val Trp Ala Lys Ile Glu Asp Gly Ile Phe Asn Val Arg225 230 235 240Ser Glu Leu Ile Glu Arg Ile Lys Asn Ala Leu Asp Ala Asn His Ile
245 250 255Glu Ile Pro Phe Asn Lys Leu Asp Ile Ala lle Lys Asn Gln Asp Ser
260265270 Pro Lys (2) sequence 931 data: (i) sequence characteristics: length (A): 833 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 762 (D) other information: (xi) Description of the sequence: sequence 931: TAGCGGTTGG GTAATTCACT CCAATCTCTA AGTGGCAGTG GCTATGAAAA C ATG CAA 57
Met Gln
1TCA CTT GCT GGG GGA TTG AGT GGT AGA GCG TGG GGA GAA ATG TTG TGT 105Ser Leu Ala Gly Gly Leu Ser Gly Arg Ala Trp Gly Glu Met Leu Cys
5 10 15AAA ATG GTA AAC GAT AGT AAT TAT GAA AGC GAG CAA GCT CTT TTA GCA 153Lys Met Val Asn Asp Ser Asn Tyr Glu Ser Glu Gln Ala Leu Leu Ala
20 25 30ACA GGC AAT AGC TCA GAA GAG CAA AAA CGA AGA TTT TTG CTT AGA GTA 201Thr Gly Asn Ser Ser Glu Glu Gln Lys Arg Arg Phe Leu Leu Arg Val35 40 45 50AAG AAA AAG GTT AAT GAT AAT AGG CAG TTA AAA AAG AAA CTT GAC CCA 249Lys Lys Lys Val Asn Asp Asn Arg Gln Leu Lys Lys Lys Leu Asp Pro
55 60 65TTT CTA AAA AGA CTT GAT GTC CTA CAA ACT GAG TTT GGT GTA ACT GAC 297Phe Leu Lys Arg Leu Asp Val Leu Gln Thr Glu Phe Gly Val Thr Asp
70 75 80CCT ACA GCT AAC CAT AAT AAG CAA GGG ATA CAT TAT TGC ACA GAA AAT 345Pro Thr Ala Asn His Asn Lys Gln Gly Ile His Tyr Cys Thr Glu Asn
85 90 95AAA AAG ACA GGT AAA TGC GAC CCT ATT GAT AAT GTA TTT AGG ACA ACT 393Lys Lys Thr Gly Lys Cys Asp Pro Ile Asp Asn Val Phe Arg Thr Thr
100 105 110CGC TTA GAT AAC GAA TTA GAA CAA GAA ATC CAA ACG CTC ACA CTT GAT 441Arg Leu Asp Asn Glu Leu Glu Gln Glu Ile Gln Thr Leu Thr Leu Asp115 120 125 130TTA ACC AAA GCC CCC AAT AAA GAC GCT CAA AGC CAA GCC TAC GCA AAT 489Leu Thr Lys Ala Pro Asn Lys Asp Ala Gln Ser Gln Ala Tyr Ala Asn
135 140 145TTC AAT CAA AGG ATT AAA TTA CTT ACT CTA AAA TAT TTA AAA GAA ATT 537Phe Asn Gln Arg Ile Lys Leu Leu Thr Leu Lys Tyr Leu Lys Glu Ile
150 155 160ACC AAT CAA ATG CTC TTT TTA AAT CAA ACA ATG GCA ATG CAA AGC GAG 585Thr Asn Gln Met Leu Phe Leu Asn Gln Thr Met Ala Met Gln Ser Glu
165 170 175ATT ATG GCA GAT GAT TAT TTT AGG CAA AAT AAT GAT GGC TTT GGG AAA 633Ile Met Ala Asp Asp Tyr Phe Arg Gln Asn Asn Asp Gly Phe Gly Lys
180 185 190GAA GAA AAC CAT ATA GAC AAA CAA TTA ACG CAA AAA AGA ATA AACGAA 681Glu Glu Asn His Ile Asp Lys Gln Leu Thr Gln Lys Arg Ile Asn Glu195 200 205 210AGA GAA AGA GCC AGA ATA TAC TTT CAA AAC CCT AAT GTT AAA TTT GAC 729Arg Glu Arg Ala Arg Ile Tyr Phe Gln Asn Pro Asn Val Lys Phe Asp
215 220 225CAA TTT GGT TTT CCC ATT TTT AGT ATA TGG GAT TAAGGGTTTA GTGATGAGAG 782Gln Phe Gly Phe Pro Ile Phe Ser Ile Trp Asp
230 235ATAGAATAAG TATTTTTTTT CCAAACTATT CCTATTTTAG TGGTAGTGTT G 833
(2) Sequence 932 data: (i) sequence characteristics: length (A): 237 amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 932: met Gln Ser Leu Ala Gly Gly Leu Ser Gly Arg Ala Trp Gly Glu Met 151015 Leu Cys Lys Met Val Asn Asp Ser Asn Tyr Glu Ser Glu Gln Ala Leu
20 25 30Leu Ala Thr Gly Asn Ser Ser Glu Glu Gln Lys Arg Arg Phe Leu Leu
35 40 45Arg Val Lys Lys Lys Vla Asn Asp Asn Arg Gln Leu Lys Lys Lys Leu
50 55 60Asp Pro Phe Leu Lys Arg Leu Asp Val Leu Gln Thr Glu Phe Gly Val65 70 75 80Thr Asp Pro Thr Ala Asn His Asn Lys Gln Gly Ile His Tyr Cys Thr
85 90 95Glu Asn Lys Lys Thr Gly Lys Cys Asp Pro Ile Asp Asn Val Phe Arg
100 105 110Thr Thr Arg Leu Asp Asn Glu Leu Glu Gln Glu Ile Gln Thr Leu Thr
115 120 125Leu Asp Leu Thr Lys Ala Pro Asn Lys Asp Ala Gln Ser Gln Ala Tyr
130 135 140Ala Asn Phe Asn Gln Arg Ile Lys Leu Leu Thr Leu Lys Tyr Leu Lys145 150 155 160Glu Ile Thr Asn Gln Met Leu Phe Leu Asn Gln Thr Met Ala Met Gln
165 170 175Ser Glu Ile Met Ala Asp Asp Tyr Phe Arg Gln Asn Asn Asp Gly Phe
180 185 190Gly Lys Glu Glu Asn His Ile Asp Lys Gln Leu Thr Gln Lys Arg Ile
195 200 205Asn Glu Arg Glu Arg Ala Arg Ile Tyr Phe Gln Asn Pro Asn Val Lys
210215220 Phe Asp Gln Phe Gly Phe Pro Ile Phe Ser Ile Trp Asp 225230235 (2) sequence 933 data: (i) sequence characteristics: length (A): 351 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 63...311 (D) other information: (xi) Description of the sequence: sequence 933: TCAAACCAAA ACCAACACAA AATTTGCTAA ACTACAATCA AATCAATTTA GGGAGGATAA 60AA ATG TCA TTT GCC CCT ATG TTA TTA GCT ACA ATC AAT AAC TCT ATT 107Met Ser Phe Ala Pro Met Leu Leu Ala Thr Ile Asn Asn Ser Ile 151015 GGC AAT AAA GAT AAG CAT GTG AGT TTA GAG TAT CTT ATA GGG CTT TTT 155Gly Asn Lys Asp Lys His Val Ser Leu Glu Tyr Leu Ile Gly Leu Phe
20 25 30ATG GAT AAA AAA ACA ACT AAT CTA AGC AAT ACT GAC AAG TAT ATT ATA 203Met Asp Lys Lys Thr Thr Asn Leu Ser Asn Thr Asp Lys Tyr Ile Ile
35 40 45GGC ACA ATT CAA ACA GAG GCA CTA GAG CAA GAA ATA GAA TGG TTT TCA 251Gly Thr Ile Gln Thr Glu Ala Leu Glu Gln Glu Ile Glu Trp Phe Ser
50 5560CAA GAC TAT CAC ATT CCT ATG GAG AAT ATT TTA CAT GTC CTT TCT ATC 299Gln Asp Tyr His Ile Pro Met Glu Asn Ile Leu His Val Leu Ser Ile
657075 AAT CCC TAT CAA TGAAAAGAGC CTTAGTTTTA TCAAAAACAA CTTTCAAGCT 351Asn Pro Tyr Gln80 (2) sequence 934 data: (i) sequence characteristics: length (A): 83 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 934: met Ser Phe Ala Pro Met Leu Leu Ala Thr Ile Asn Asn Ser Ile Gly 151015 Asn Lys Asp Lys His Val Ser Leu Glu Tyr Leu Ile Gly Leu Phe Met
20 25 30Asp Lys Lys Thr Thr Asn Leu Ser Asn Thr Asp Lys Tyr Ile Ile Gly
35 40 45Thr Ile Gln Thr Glu Ala Leu Glu Gln Glu Ile Glu Trp Phe Ser Gln
50 55 60Asp Tyr His Ile Pro Met Glu Asn Ile Leu His Val Leu Ser Ile Asn65 70 75 80Pro Tyr Gln
(2) Sequence 935 data: (i) sequence characteristics: length (A): 1934 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 67...1866
(D) Other information: (xi) Description of the sequence: sequence 935: AAACATAGGG CAAATCTAGT TGGCACAAAA ACAGCTAGTC CTGTGCTTAT TAAAAACATA 60GGGCAA ATG AAA CGC TCC CAC TTA GAA AAT GCC CTA AAT TAT GCT TTA 108
Met Lys Arg Ser His Leu Glu Asn Ala Leu Asn Tyr Ala Leu
1 5 10GAA AAT AGC GAA ACA GCT TAC AAT GAA ATG TTT TTA GAA TGC GAT AAG 156Glu Asn Ser Glu Thr Ala Tyr Asn Glu Met Phe Leu Glu Cys Asp Lys15 20 25 30CAA TTC ATC TTA GAG AGT TGG CTC AAT GAC TTT GAT TTG ACT AAA GAT 204Gln Phe Ile Leu Glu Ser Trp Leu Asn Asp Phe Asp Leu Thr Lys Asp
35 40 45TAT AAC GAG ACT ATG CAC TTA GTT TTT TCT ATC AAA GAT AAG CCA GAT 252Tyr Asn Glu Thr Met His Leu Val Phe Ser Ile Lys Asp Lys Pro Asp
50 55 60GAA GAG ACA ATG CAA GGG CTT TTA CAT TCT ACT TGG GAG AGC TTA AAA 300Glu Glu Thr Met Gln Gly Leu Leu His Ser Thr Trp Glu Ser Leu Lys
65 70 75ATA AGA TTG CCT GAA TAC AAG TTT GCC CTT GTG CCA CAC GCT CAT CAA 348Ile Arg Leu Pro Glu Tyr Lys Phe Ala Leu Val Pro His Ala His Gln
80 85 90GAC CAT GCC CAT ATC CAT TGT TTT ATC AAT AAG ACT AAT CAG CTC ACA 396Asp His Ala His Ile His Cys Phe Ile Asn Lys Thr Asn Gln Leu Thr95 100 105 110CGA AGA AGA CTG CGT TTT AAG GGG CAT GAA GAT TGT AAA GAA TTT TTT 444Arg Arg Arg Leu Arg Phe Lys Gly His Glu Asp Cys Lys Glu Phe Phe
115 120 125AAT GAA TTA AGA AGT GAG TTT GCT TAT AGG TTG AAT GAC CAC TTA TTG 492Asn Glu Leu Arg Ser Glu Phe Ala Tyr Arg Leu Asn Asp His Leu Leu
130 135 140AGC GAA GAA TAG TTG TAT GTC AAT GAG CCA AAA CTT AAA GAG CTA GAC 540Ser Glu Glu Tyr Leu Tyr Val Asn Glu Pro Lys Leu Lys Glu Leu Asp
145 150 155AAT ATC AAA CAA CAA TTA CAA GAC TTG GAA AAA GAA GAA AAA GCC TTA 588Asn Ile Lys Gln Gln Leu Gln Asp Leu Glu Lys Glu Glu Lys Ala Leu
160 165 170GAA CAA ATC AAA TCC CCA CAA GAT GAG TGG GAC TTA AAC AAG GCT TTA 636Glu Gln Ile Lys Ser Pro Gln Asp Glu Trp Asp Leu Asn Lys Ala Leu175 180 185 190CAA AGC GAG TAT TTA CAA GAA CTC AAA TAT AAA AAC AAA GCA AAA GCC 684Gln Ser Glu Tyr Leu Gln Glu Leu Lys Tyr Lys Asn Lys Ala Lys Ala
195 200 205CTA GAC ATT CAA AAT AAC CAC AGC ACC CCT TTA AAA CAA AAG ATT TCT 732Leu Asp Ile Gln Asn Asn His Ser Thr Pro Leu Lys Gln Lys Ile Ser
210 215 220GAA TTT AAA ATC GCT CTG TTT AAT CAC AAA GAC ACA AGC GAT GAT GAA 780Glu Phe Lys Ile Ala Leu Phe Asn His Lys Asp Thr Ser Asp Asp Glu
225 230 235AAA GAA CAG CTA GAT ATT GAC AGG ATA GAT AAG AGA AAA CCA GTA AGC 828Lys Glu Gln Leu Asp Ile Asp Arg Ile Asp Lys Arg Lys Pro Val Ser
240 245 250GAA CAC TTA AAA AAC ACT AAC AAA CAC GAG CTA TAC GAA CTC TTA GGC 876Glu His Leu Lys Asn Thr Asn Lys His Glu Leu Tyr Glu Leu Leu Gly255 260 265 270TTT TAT CAA AAA GAA TTA GAT AAA AAA CAA AAC CAT TCA GCC TTT AAG 924Phe Tyr Gln Lys Glu Leu Asp Lys Lys Gln Asn His Ser Ala Phe Lys
275 280 285AAT TTT GCT ATT CTC AAT GGT TTA GAC AGA GAC TTT GAA AGA GAG ACT 972Asn Phe Ala Ile Leu Asn Gly Leu Asp Arg Asp Phe Glu Arg Glu Thr
290 295 300AAT GGC TAT TCT GTT TTA AAG AAA AAA GAA ATG CTT TTA AAT AAG CTT 1020Asn Gly Tyr Ser Val Leu Lys Lys Lys Glu Met Leu Leu Asn Lys Leu
305 310 315GAA CAC CTA GAC AAA CGC CTT TTA GAT AAA AAC TCA CAC TTA CTA TTA 1068Glu His Leu Asp Lys Arg Leu Leu Asp Lys Asn Ser His Leu Leu Leu
320 325 330GCC CAG CTA AGA AAT GAA GTT AAA ACG AAG CAA AAC ATC CAA TAC AAC 1116Ala Gln Leu Arg Asn Glu Val Lys Thr Lys Gln Asn Ile Gln Tyr Asn335 340 345 350ACT CTA ACT AAT CCT ATT CTT TTA GCC AAA GCC TTA GAA CTT TCT AAA 1164Thr Leu Thr Asn Pro Ile Leu Leu Ala Lys Ala Leu Glu Leu Ser Lys
355 360 365GAT AAA CGC CCC ACT CTC AAA ACT TTT AAA AAC GCT TAT TTT AGT GCT 1212Asp Lys Arg Pro Thr Leu Lys Thr Phe Lys Asn Ala Tyr Phe Ser Ala
370 375 380AGA AAA TAT CAA TTC ATG CTA GAG AGC TTT AAA ACT AAG CAA AAT GAC 1260Arg Lys Tyr Gln Phe Met Leu Glu Ser Phe Lys Thr Lys Gln Asn Asp
385 390 395CCC ACT TAC AAG CTT AAT GAT AAC ACT TAT GAG CTA GTG AGT AAG CAA 1308Pro Thr Tyr Lys Leu Asn Asp Asn Thr Tyr Glu Leu Val Ser Lys Gln
400 405 410CTA CAA GAC TAT CAA AAC ACC ATG CTT TTA TTA GCC AAA GAG AGA TTA 1356Leu Gln Asp Tyr Gln Asn Thr Met Leu Leu Leu Ala Lys Glu Arg Leu415 420 425 430CTT TTT TTA GAA CAA GAT TTA AAA CAA AAA GAA GAA GAG TTT GAA AGA 1404Leu Phe Leu Glu Gln Asp Leu Lys Gln Lys Glu Glu Glu Phe Glu Arg
435 440 445GCC AAA GAA CAT TAT GTG AAA TCT TCA AAA CAT TAT AGA GAA ACT TCA 1452Ala Lys Glu His Tyr Val Lys Ser Ser Lys His Tyr Arg Glu Thr Ser
450 455 460TTG TCT CCA AAA GAA AAA CAA GGC TTT CTC AAA CAA ATT AAA CAA TTT 1500Leu Ser Pro Lys Glu Lys Gln Gly Phe Leu Lys Gln Ile Lys Gln Phe
465 470 475TCT AAA ATT TCT AAG GAT ATT CTC TAT ACT TGT AAT GAG ATC ATA GGA 1548Ser Lys Ile Ser Lys Asp Ile Leu Tyr Thr Cys Asn Glu Ile Ile Gly
480 485 490GCT AAT AGG TTT TTA ACC CAC TAT GAC AAC CTA AAC CTT GAA AAA GTC 1596Ala Asn Arg Phe Leu Thr His Tyr Asp Asn Leu Asn Leu Glu Lys Val495 500 505 510CTA GAA CAC GCT AAA GAT ACT AAG CTA GAG CAA AAA GAA ATT CAA GCT 1644Leu Glu His Ala Lys Asp Thr Lys Leu Glu Gln Lys Glu Ile Gln Ala
515 520 525ATC ACA AAA GAG CCT AAT AAC GAT GAG CCT TGG ATT GAG TTT GGT AAA 1692Ile Thr Lys Glu Pro Asn Asn Asp Glu Pro Trp Ile Glu Phe Gly Lys
530 535 540AAA GAA CAA GCT AGA GCT AAA GCA CAC TAT CAA GCT ATG CTA GAA AAA 1740Lys Glu Gln Ala Arg Ala Lys Ala His Tyr Gln Ala Met Leu Glu Lys
545 550 555GAA AAA GCT AAA GAA TTA GCT AAA CAA CAA GCT AAC ACC TTG CAC TCT 1788Glu Lys Ala Lys Glu Leu Ala Lys Gln Gln Ala Asn Thr Leu His Ser
560 565 570AAT GAG CTT GAT GAT GAC CCT AAA GCT CAT GCT GGA TTA AAA CAA AAT 1836Asn Glu Leu Asp Asp Asp Pro Lys Ala His Ala Gly Leu Lys Gln Asn575 580 585 590GAC AAC ACA AAC TTT AAA GGG CGT AAT AGA TAATGCTCTC AAGCGATGAT TGC 1889Asp Asn Thr Asn Phe Lys Gly Arg Asn Arg
595600 CTTTAATGTT CTTAATAAAG AATATACCCT TTGAAAGGGG TTTAT 1934 (2) sequence 936 data: (i) sequence characteristics: length (A): 600 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequencedescription: sequence 936: met Lys Arg Ser His Leu Glu Asn Ala Leu Asn Tyr Ala Leu Glu Asn 151015 Ser Glu Thr Ala Tyr Asn Glu Met Phe Leu Glu Cys Asp Lys Gln Phe
20 25 30Ile Leu Glu Ser Trp Leu Asn Asp Phe Asp Leu Thr Lys Asp Tyr Asn
35 40 45Glu Thr Met His Leu Val Phe Ser Ile Lys Asp Lys Pro Asp Glu Glu
50 55 60Thr Met Gln Gly Leu Leu His Ser Thr Trp Glu Ser Leu Lys Ile Arg65 70 75 80Leu Pro Glu Tyr Lys Phe Ala Leu Val Pro His Ala His Gln Asp His
85 90 95Ala His Ile His Cys Phe Ile Asn Lys Thr Asn Gln Leu Thr Arg Arg
100 105 110Arg Leu Arg Phe Lys Gly His Glu Asp Cys Lys Glu Phe Phe Asn Glu
115 120 125Leu Arg Ser Glu Phe Ala Tyr Arg Leu Asn Asp His Leu Leu Ser Glu
130 135 140Glu Tyr Leu Tyr Val Asn Glu Pro Lys Leu Lys Glu Leu Asp Asn Ile145 150 155 160Lys Gln Gln Leu Gln Asp Leu Glu Lys Glu Glu Lys Ala Leu Glu Gln
165 170 175Ile Lys Ser Pro Gln Asp Glu Trp Asp Leu Asn Lys Ala Leu Gln Ser
180 185 190Glu Tyr Leu Gln Glu Leu Lys Tyr Lys Asn Lys Ala Lys Ala Leu Asp
195 200 205Ile Gln Asn Asn His Ser Thr Pro Leu Lys Gln Lys Ile Ser Glu Phe
210 215 220Lys Ile Ala Leu Phe Asn His Lys Asp Thr Ser Asp Asp Glu Lys Glu225 230 235 240Gln Leu Asp Ile Asp Arg Ile Asp Lys Arg Lys Pro Val Ser Glu His
245 250 255Leu Lys Asn Thr Asn Lys His Glu Leu Tyr Glu Leu Leu Gly Phe Tyr
260 265 270Gln Lys Glu Leu Asp Lys Lys Gln Asn His Ser Ala Phe Lys Asn Phe
275 280 285Ala Ile Leu Asn Gly Leu Asp Arg Asp Phe Glu Arg Glu Thr Asn Gly
290 295 300Tyr Ser Val Leu Lys Lys Lys Glu Met Leu Leu Asn Lys Leu Glu His305 310 315 320Leu Asp Lys Arg Leu Leu Asp Lys Asn Ser His Leu Leu Leu Ala Gln
325 330 335Leu Arg Asn Glu Val Lys Thr Lys Gln Asn Ile Gln Tyr Asn Thr Leu
340 345 350Thr Asn Pro Ile Leu Leu Ala Lys Ala Leu Glu Leu Ser Lys Asp Lys
355 360 365Arg Pro Thr Leu Lys Thr Phe Lys Asn Ala Tyr Phe Ser Ala Arg Lys
370 375 380Tyr Gln Phe Met Leu Glu Ser Phe Lys Thr Lys Gln Asn Asp Pro Thr385 390 395 400Tyr Lys Leu Asn Asp Asn Thr Tyr Glu Leu Val Ser Lys Gln Leu Gln
405 410 415Asp Tyr Gln Asn Thr Met Leu Leu Leu Ala Lys Glu Arg Leu Leu Phe
420 425 430Leu Glu Gln Asp Leu Lys Gln Lys Glu Glu Glu Phe Glu Arg Ala Lys
435 440 445Glu His Tyr Val Lys Ser Ser Lys His Tyr Arg GluThr Ser Leu Ser
450 455 460Pro Lys Glu Lys Gln Gly Phe Leu Lys Gln Ile Lys Gln Phe Ser Lys465 470 475 480Ile Ser Lys Asp Ile Leu Tyr Thr Cys Asn Glu Ile Ile Gly Ala Asn
485 490 495Arg Phe Leu Thr His Tyr Asp Asn Leu Asn Leu Glu Lys Val Leu Glu
500 505 510His Ala Lys Asp Thr Lys Leu Glu Gln Lys Glu Ile Gln Ala Ile Thr
515 520 525Lys Glu Pro Asn Asn Asp Glu Pro Trp Ile Glu Phe Gly Lys Lys Glu
530 535 540Gln Ala Arg Ala Lys Ala His Tyr Gln Ala Met Leu Glu Lys Glu Lys545 550 555 560Ala Lys Glu Leu Ala Lys Gln Gln Ala Asn Thr Leu His Ser Asn Glu
565 570 575Leu Asp Asp Asp Pro Lys Ala His Ala Gly Leu Lys Gln Asn Asp Asn
580 585 590Thr Asn Phe Lys Gly Arg Asn Arg
595600 (2) sequence 937 data: (i) sequence characteristics: length (A): 884 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 840 (D) other information: (xi) Description of the sequence: sequence 937: GGAGAATAAA ATTACAATAA A ATG GCG TTA GAA AAA AGT TAT AGT AAA AAC 51
Met Ala Leu Glu Lys Ser Tyr Ser Lys Asn
1 5 10TTT GAA AGC GAT GAG CTT TTT GAT TAT GAG ATC ATC AAG CCC AAA AAG 99Phe Glu Ser Asp Glu Leu Phe Asp Tyr Glu Ile Ile Lys Pro Lys Lys
15 20 25ACG CTT AAG ATA CAA TAC ACT TAT GCT AAA CGC TAC TAT AAA GAA GTA 147Thr Leu Lys Ile Gln Tyr Thr Tyr Ala Lys Arg Tyr Tyr Lys Glu Val
30 35 40GAA AAG TTT GCT AAA AAT TTA ACC CAA CTG ACA CAA GAA GAA TTC ATG 195Glu Lys Phe Ala Lys Asn Leu Thr Gln Leu Thr Gln Glu Glu Phe Met
45 50 55CGT TTA AGA GAG CCA CAA AAA CAA GTG GTC ATC AAA AAC ATA GGC AAT 243Arg Leu Arg Glu Pro Gln Lys Gln Val Val Ile Lys Asn Ile Gly Asn
60 65 70ATG ACA CGC CTG CAT TCA AAA AGA GCG ATG GAT TAT ATC GCT AAA CAT 291Met Thr Arg Leu His Ser Lys Arg Ala Met Asp Tyr Ile Ala Lys His75 80 85 90GGT GAG CTA GTG AGA GAT GAA TTT TTT AAT GAA GTT AAT TAT AAT GAC 339Gly Glu Leu Val Arg Asp Glu Phe Phe Asn Glu Val Asn Tyr Asn Asp
95 100 105ATA GCA GAG CAA TGG AAT GAG CAA TTT GAA AAA TTA TTA GAA AAT AAG 387Ile Ala Glu Gln Trp Asn Glu Gln Phe Glu Lys Leu Leu Glu Asn Lys
110 115 120AGC CGT GTT AAA AAT TGC GCT TTA CAT CTA GTG TTT AGC ATT GAT GAA 435Ser Arg Val Lys Asn Cys Ala Leu His Leu Val Phe Ser Ile Asp Glu
125 130 135AAT TGT AAT GAA AAA AAT TTA AAA GCT TTG GAA TTA AGC GTG TAT CAA 483Asn Cys Asn Glu Lys Asn Leu Lys Ala Leu Glu Leu Ser Val Tyr Gln
140 145 150ACA CTC ACT AAC ACG CTA GGT TAT GAT TAT CCT TTT ATA ATG AAA CTC 531Thr Leu Thr Asn Thr Leu Gly Tyr Asp Tyr Pro Phe Ile Met Lys Leu155 160165 170CAT ACA CAC CAA AAC AAT CCG CAT GCG CAT GTG ATT ATC AAC AAA ACT 579His Thr His Gln Asn Asn Pro His Ala His Val Ile Ile Asn Lys Thr
175 180 185AAC AAA ATT ACC AAT AAG CAA CTA TGC TTT AAT TCT AAA GAC AGC TGT 627Asn Lys Ile Thr Asn Lys Gln Leu Cys Phe Asn Ser Lys Asp Ser Cys
190 195 200AAA GAG TTT TAC CAC ACA CTA AGA GAA ACA TTT AAA GAT TAT TTA TTT 675Lys Glu Phe Tyr His Thr Leu Arg Glu Thr Phe Lys Asp Tyr Leu Phe
205 210 215GCT AAC TCA AAA GGC GAA TTG CAA TAT TCT AAC ACG CCT AAT ATT TAT 723Ala Asn Ser Lys Gly Glu Leu Gln Tyr Ser Asn Thr Pro Asn Ile Tyr
220 225 230AAG GCG ATT AAA GAC ATA GAA ACA GAG CTA GAT GCA CTA GAA AAC AGG 771Lys Ala Ile Lys Asp Ile Glu Thr Glu Leu Asp Ala Leu Glu Asn Arg235 240 245 250CTA GAA ACA ATA AGA GTT TTA GGC ATG AAA ACT ATT TTT ATA AAG TTT 819Leu Glu Thr Ile Arg Val Leu Gly Met Lys Thr Ile Phe Ile Lys Phe
255 260 265TGG GTA GTG CAA CTT CTC AAA TAGAAAGTTT GAAAAAAAGA GAAAATGCCC TATT 874Trp Val Val Gln Leu Leu Lys
270TGATCATTTA 884 (2) sequence 938 data: (i) sequence characteristics: length (A): 273 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein
(xi) Description of the sequence: sequence 938: met Ala Leu Glu Lys Ser Tyr Ser Lys Asn Phe Glu Ser Asp Glu Leu 151015 Phe Asp Tyr Glu Ile Ile Lys Pro Lys Lys Thr Leu Lys Ile Gln Tyr
20 25 30Thr Tyr Ala Lys Arg Tyr Tyr Lys Glu Val Glu LysPhe Ala Lys Asn
35 40 45Leu Thr Gln Leu Thr Gln Glu Glu Phe Met Arg Leu Arg Glu Pro Gln
50 55 60Lys Gln Val Val Ile Lys Asn Ile Gly Asn Met Thr Arg Leu His Ser65 70 75 80Lys Arg Ala Met Asp Tyr Ile Ala Lys His Gly Glu Leu Val Arg Asp
85 90 95Glu Phe Phe Asn Glu Val Asn Tyr Asn Asp Ile Ala Glu Gln Trp Asn
100 105 110Glu Gln Phe Glu Lys Leu Leu Glu Asn Lys Ser Arg Val Lys Asn Cys
115 120 125Ala Leu His Leu Val Phe Ser Ile Asp Glu Asn Cys Asn Glu Lys Asn
130 135 140Leu Lys Ala Leu Glu Leu Ser Val Tyr Gln Thr Leu Thr Asn Thr Leu145 150 155 160Gly Tyr Asp Tyr Pro Phe Ile Met Lys Leu His Thr His Gln Asn Asn
165 170 175Pro His Ala His Val Ile Ile Asn Lys Thr Asn Lys Ile Thr Asn Lys
180 185 190Gln Leu Cys Phe Asn Ser Lys Asp Ser Cys Lys Glu Phe Tyr His Thr
195 200 205Leu Arg Glu Thr Phe Lys Asp Tyr Leu Phe Ala Asn Ser Lys Gly Glu
210 215 220Leu Gln Tyr Ser Asn Thr Pro Asn Ile Tyr Lys Ala Ile Lys Asp Ile225 230 235 240Glu Thr Glu Leu Asp Ala Leu Glu Asn Arg Leu Glu Thr Ile Arg Val
245 250 255Leu Gly Met Lys Thr Ile Phe Ile Lys PheTrp Val Val Gln Leu Leu
260265270 Lys (2) sequence 939 data: (i) sequence characteristics: length (A): 557 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 519 (D) other information:
(xi) Description of the sequence: sequence 939: ATAAACAACC ATGACAAACT AACGGACTTT AAGCAATACC AAACAGAC ATG AAA GAA 57
Met Lys Glu
1TTA CTA GGG ATA GAA ATA GAT GAA GAG CTG GAT ACT AAA CGA CTT ATC 105Leu Leu Gly Ile Glu Ile Asp Glu Glu Leu Asp Thr Lys Arg Leu Ile
5 10 15CCT ACT TAT TCC AAA TTG TAT TCT TTA AAA AAA TAC TCT AAA AAA TTT 153Pro Thr Tyr Ser Lys Leu Tyr Ser Leu Lys Lys Tyr Ser Lys Lys Phe20 25 30 35AAA AGA TTA CAA AGA AAA CAA AGC CGT AGG GTG TTA AAG TCT AAA CAA 201Lys Arg Leu Gln Arg Lys Gln Ser Arg Arg Val Leu Lys Ser Lys Gln
40 45 50AAC AAA ACC AAA TTA GGA GGT AAT TTT TAC AAA ACC CAA AAG AAA TTA 249Asn Lys Thr Lys Leu Gly Gly Asn Phe Tyr Lys Thr Gln Lys Lys Leu
55 60 65AAC CAA GCC TTT GAC AAG TCT AGT CAT CAA AAA ACA GAC AGA TAC CAT 297Asn Gln Ala Phe Asp Lys Ser Ser His Gln Lys Thr Asp Arg Tyr His
70 75 80AAA ATC ACA AGC GAA CTT TCA AAG CAA TTT GAA TTG ATA GTA GTT GAA 345Lys Ile Thr Ser Glu Leu Ser Lys Gln Phe Glu Leu Ile Val Val Glu
85 90 95GAT TTG CAA GTA AAA AAC ATG ACT AAA AGA GCT AAA CTC AAA AAT GTT 393Asp Leu Gln Val Lys Asn Met Thr Lys Arg Ala Lys Leu Lys Asn Val100 105 110 115AAA CAA AAG AGT GGG CTT AAT CAA TCT ATT TTA AAC GCT TCA TTC TAT 441Lys Gln Lys Ser Gly Leu Asn Gln Ser Ile Leu Asn Ala Ser Phe Tyr
120 125 130CAA ATC ATC TCT TTT TTA GAC TAC AAA CAA CAG CAT AAT GGC AAA TTG 489Gln Ile Ile Ser Phe Leu Asp Tyr Lys Gln Gln His Asn Gly Lys Leu
135 140 145TTA GTG AAA GTT TCC CCC ACA ATA TAC GAG TAAAACTTGC CATTGTTGTG GGA 542Leu Val Lys Val Ser Pro Thr Ile Tyr Glu
150155 ATATCAACCA CAAGC 557 (2) sequence 940 data: (i) sequence characteristics: length (A): 157 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 940: met Lys Glu Leu Leu Gly Ile Glu Ile Asp Glu Glu Leu Asp Thr Lys 151015 Arg Leu Ile Pro Thr Tyr Ser Lys Leu Tyr Ser Leu Lys Lys Tyr Ser
20 25 30Lys Lys Phe Lys Arg Leu Gln Arg Lys Gln Ser Arg Arg Val Leu Lys
35 40 45Ser Lys Gln Asn Lys Thr Lys Leu Gly Gly Asn Phe Tyr Lys Thr Gln
50 55 60Lys Lys Leu Asn Gln Ala Phe Asp Lys Ser Ser His Gln Lys Thr Asp65 70 75 80Arg Tyr His Lys Ile Thr Ser Glu Leu Ser Lys Gln Phe Glu Leu Ile
85 90 95Val Val Glu Asp Leu Gln Val Lys Asn Met Thr Lys Arg Ala Lys Leu
100 105 110Lys Asn Val Lys Gln Lys Ser Gly Leu Asn Gln Ser Ile Leu Asn Ala
115 120 125Ser Phe Tyr Gln Ile Ile Ser Phe Leu Asp Tyr Lys Gln Gln His Asn
130 135 140Gly Lys Leu Leu Val Lys Val Ser Pro Thr Ile Tyr Glu145 150 155
(2) Data of sequence 941: (i) sequence characteristics:
(A) length: 889 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 52...843
(D) Other information: (xi) sequence description: sequence 941: ATTACATTCT TTTTGATTTC TATTGAAAAA TTTAATATTA AGAGGACTTT T ATG AAA 57
Met Lys
1AAA TCA AAT GAC AAT AAC GCA CTC GCC AGA AGT CAA AGG GAG TTG TTT 105Lys Ser Asn Asp Asn Asn Ala Leu Ala Arg Ser Gln Arg Glu Leu Phe
5 10 15GTA GGG ATT AGG GAT TTT ATT GTT TTT AAA TTT AAG CGT ATG GTT GTT 153Val Gly Ile Arg Asp Phe Ile Val Phe Lys Phe Lys Arg Met Val Val
20 25 30TTT AAC GGA GTA AGG GAT TTT ACA AAA ATG AGA TTT TTG TCC ATA GAA 201Phe Asn Gly Val Arg Asp Phe Thr Lys Met Arg Phe Leu Ser Ile Glu35 40 45 50TTA GAA AAA TGC GAA AAT ATT AAA GAT TTG GAA AAA TTA TGT CAT ACA 249Leu Glu Lys Cys Glu Asn Ile Lys Asp Leu Glu Lys Leu Cys His Thr
5560 65ATT TAT AAT CAA GGC ACA AAG CAT ATT TTG ATG ATG CGT GTA TTG TTT 297Ile Tyr Asn Gln Gly Thr Lys His Ile Leu Met Met Arg Val Leu Phe
70 75 80TTA TTC TTT GAC TAT TTC TGC AAG CAT TTG AAA GTT AAG CGA TTG AGA 345Leu Phe Phe Asp Tyr Phe Cys Lys His Leu Lys Val Lys Arg Leu Arg
85 90 95CTA CTC AAT GAA GAA ATG CTT GTG AAT TTT TTA TTT GAG TTA GCT AAA 393Leu Leu Asn Glu Glu Met Leu Val Asn Phe Leu Phe Glu Leu Ala Lys
100 105 110CAA AGA AAA ATT AAT TCA ATG GCA AAA TAT GTG ATG TAT ATT AGG CAA 441Gln Arg Lys Ile Asn Ser Met Ala Lys Tyr Val Met Tyr Ile Arg Gln115 120 125 130TTT TTT GAT TAC TTG GAT AGG ACT AAA CAT TAT GAA TTT TAT TTT AGT 489Phe Phe Asp Tyr Leu Asp Arg Thr Lys His Tyr Glu Phe Tyr Phe Ser
135 140 145CTT AAA AAT ATA GCC TTT GCT AAA CAC AAG GAT AAT TTG CCT AAG CAT 537Leu Lys Asn Ile Ala Phe Ala Lys His Lys Asp Asn Leu Pro Lys His
150 155 160CTA AAT TCA AAA GAT TTA AAA TCT TTT ATA TAT ACT CTT ATA AAC TAT 585Leu Asn Ser Lys Asp Leu Lys Ser Phe Ile Tyr Thr Leu Ile Asn Tyr
165 170 175AGA ACT AGA AGC AGT TAT GAA AAG AGA AAT AAG TGT ATT TTG CTC TTG 633Arg Thr Arg Ser Ser Tyr Glu Lys Arg Asn Lys Cys Ile Leu Leu Leu
180 185 190ATT ATT TTG GGT GGT TTG AGA AAA TCT GAG GTT TTT AAT TTA GAA TTG 681Ile Ile Leu Gly Gly Leu Arg Lys Ser Glu Val Phe Asn Leu Glu Leu195 200 205 210AGA AAT ATT GTT TTA GAG AAA GAG CAT TAT ATC TTG CTT ATA AAA GGC729Arg Asn Ile Val Leu Glu Lys Glu His Tyr Ile Leu Leu Ile Lys Gly
215 220 225AAA AAC AAT AAA GAG CGA AAA GCG TTC ATT AAA ATC GCT CAA ACA GAT 777Lys Asn Asn Lys Glu Arg Lys Ala Phe Ile Lys Ile Ala Gln Thr Asp
230 235 240ATT GAC ACA CTC GCA CCG CTT ATC CGT ATC CTT TTG GAA AGT ATT GCT 825Ile Asp Thr Leu Ala Pro Leu Ile Arg Ile Leu Leu Glu Ser Ile Ala
245 250 255AAA AAT CTT TTA TCC CAC TAGCGCGAAA AACTCCGTCC TTTAGGGCGG AGATGTAA 881Lys Asn Leu Leu Ser His
260GCGTTTAG 889 (2) sequence 942 data: (i) sequence characteristics: length (A): 264 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 942: met Lys Lys Ser Asn Asp Asn Asn Ala Leu Ala Arg Ser Gln Arg Glu 151015 Leu Phe Val Gly Ile Arg Asp Phe Ile Val Phe Lys Phe Lys Arg Met
20 25 30Val Val Phe Asn Gly Val Arg Asp Phe Thr Lys Met Arg Phe Leu Ser
35 40 45Ile Glu Leu Glu Lys Cys Glu Asn Ile Lys Asp Leu Glu Lys Leu Cys
50 55 60His Thr Ile Tyr Asn Gln Gly Thr Lys His Ile Leu Met Met Arg Val65 70 75 80Leu Phe Leu Phe Phe Asp Tyr Phe Cys Lys His Leu Lys Val Lys Arg
85 90 95Leu Arg Leu Leu Asn Glu Glu Met Leu Val Asn Phe Leu Phe Glu Leu
100 105 110Ala Lys Gln Arg Lys Ile Asn Ser Met Ala Lys Tyr Val Met Tyr Ile
115 120 125Arg Gln Phe Phe Asp Tyr Leu Asp Arg Thr Lys His Tyr Glu Phe Tyr
130 135 140Phe Ser Leu Lys Asn Ile Ala Phe Ala Lys His Lys Asp Asn Leu Pro145 150 155 160Lys His Leu Asn Ser Lys Asp Leu Lys Ser Phe Ile Tyr Thr Leu Ile
165 170 175Asn Tyr Arg Thr Arg Ser Ser Tyr Glu Lys Arg Asn Lys Cys Ile Leu
180 185 190Leu Leu Ile Ile Leu Gly Gly Leu Arg Lys Ser Glu Val Phe Asn Leu
195 200 205Glu Leu Arg Asn Ile Val Leu Glu Lys Glu His Tyr Ile Leu Leu Ile
210 215 220Lys Gly Lys Asn Asn Lys Glu Arg Lys Ala Phe Ile Lys Ile Ala Gln225 230 235 240Thr Asp Ile Asp Thr Leu Ala Pro Leu Ile Arg Ile Leu Leu Glu Ser
245 250 255Ile Ala Lys Asn Leu Leu Ser His
260 (2) sequence 943 data: (i) sequence characteristics: length (A): 546 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 530 (D) other information:
(xi) Description of the sequence: sequence 943: TTGACAGAGT GGATTTTTTT ATTTCTAACG CTATTATTTA TGGGCGTTCT GTCGTGGGGG 60GATTTGCACC GTTT ATG CGA TTA AAA CCT AAG GGG TTA AAC AAC ATT TAC 110
Met Arg Leu Lys Pro Lys Gly Leu Asn Asn Ile Tyr
1 5 10ACA GCC ACC GTG TTA GCG TTC GTC GTA GGG GCT CAA GAA GCG GCA AAA158Thr Ala Thr Val Leu Ala Phe Val Val Gly Ala Gln Glu Ala Ala Lys
15 20 25CGC ATG CAA AAA ATA GGC GGT GGG GCG ATC GTG AGC TTA AGT TCT ACC 206Arg Met Gln Lys Ile Gly Gly Gly Ala Ile Val Ser Leu Ser Ser Thr
30 35 40GGG AAT CTA GTT TAT ATG CCT AAT TAC GCC GGG CAT GGC AAT TCC AAA 254Gly Asn Leu Val Tyr Met Pro Asn Tyr Ala Gly His Gly Asn Ser Lys45 50 55 60AAC GCC GTA GAA ACC ATG GTC AAA TAC GCT GCC GTG GAT TTA GGC GAA 302Asn Ala Val Glu Thr Met Val Lys Tyr Ala Ala Val Asp Leu Gly Glu
65 70 75TTT AAC ATT AGA GTG AAT GCG GTT AGT GGC GGG CCT ATT GAT ACG GAC 350Phe Asn Ile Arg Val Asn Ala Val Ser Gly Gly Pro Ile Asp Thr Asp
80 85 90GCT TTG AAA GCC TTC CCT GAT TAT GTG GAG ATT AAA GAA AAA GTA GAA 398Ala Leu Lys Ala Phe Pro Asp Tyr Val Glu Ile Lys Glu Lys Val Glu
95 100 105GAG CAA TCG CCC CTA AAA CGC ATG GGC AAT CCT AAC GAT CTA GCC GGA 446Glu Gln Ser Pro Leu Lys Arg Met Gly Asn Pro Asn Asp Leu Ala Gly
110 115 120GCG GCT TAT TTT TTA TGC GAT GAG ACC CAA AGC GGT TGG CTT ACA GGG 494Ala Ala Tyr Phe Leu Cys Asp Glu Thr Gln Ser Gly Trp Leu Thr Gly125 130 135 140CAA ACG ATC GTT GTA GAT GGC GGG ACT ACT TTT AAA TAAAGATATT TCTTGC 546Gln Thr Ile Val Val Asp Gly Gly Thr Thr Phe Lys
145150 (2) sequence 944 data: (i) sequence characteristics: length (A): 152 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 944: met Arg Leu Lys Pro Lys Gly Leu Asn Asn Ile Tyr Thr Ala Thr Val 151015 Leu Ala Phe Val Val Gly Ala Gln Glu Ala Ala Lys Arg Met Gln Lys
20 25 30Ile Gly Gly Gly Ala Ile Val Ser Leu Ser Ser Thr Gly Asn Leu Val
35 40 45Tyr Met Pro Asn Tyr Ala Gly His Gly Asn Ser Lys Asn Ala Val Glu
50 55 60Thr Met Val Lys Tyr Ala Ala Val Asp Leu Gly Glu Phe Asn Ile Arg65 70 75 80Val Asn Ala Val Ser Gly Gly Pro Ile Asp Thr Asp Ala Leu Lys Ala
85 90 95Phe Pro Asp Tyr Val Glu Ile Lys Glu Lys Val Glu Glu Gln Ser Pro
100 105 110Leu Lys Arg Met Gly Asn Pro Asn Asp Leu Ala Gly Ala Ala Tyr Phe
115 120 125Leu Cys Asp Glu Thr Gln Ser Gly Trp Leu Thr Gly Gln Thr Ile Val
130135140 Val Asp Gly Gly Thr Thr Phe Lys 145150 (2) sequence 945 data: (i) sequence characteristics: length (A): 644 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 616 (D) other information: (xi) Description of the sequence: sequence 945: a AGA TAT TTC TTG CAA AAC ATT ATC CAC ATC CAC CAA AAC AAA GAG TTG 49 Arg Tyr Phe Leu Gln Asn Ile Ile His Ile His Gln Asn Lys Glu Leu 151015 CAA TTC ATT AAA AAA TGC TTG TTG GGC TAT TTT TTC GCC CCT TTG TGT 97Gln Phe Ile Lys Lys Cys Leu Leu Gly Tyr Phe Phe Ala Pro Leu Cys
20 25 30GGG GCT ATT CTG TTA GTG CTT TTT ATT GTT TCA AGC GGG GCA AAA TCG 145Gly Ala Ile Leu Leu Val Leu Phe Ile Val Ser Ser Gly Ala Lys Ser
35 40 45TTT CAA ATT TCT AAT CTC TTT AAC AAT CAA CTA GCC TAT ATC GTT TTG 193Phe Gln Ile Ser Asn Leu Phe Asn Asn Gln Leu Ala Tyr Ile Val Leu
50 55 60TTG TCT CTT TTT TTG TGC GCG CTT GGG TTT ATT GCC GGA GCG ATT GGT 241Leu Ser Leu Phe Leu Cys Ala Leu Gly Phe Ile Ala Gly Ala Ile Gly65 70 75 80TTT TAT AGG CTT TCT AAA ATC ACA CGC CAT CTG AGTTTT TTT GAA AAT 289Phe Tyr Arg Leu Ser Lys Ile Thr Arg His Leu Ser Phe Phe Glu Asn
85 90 95TTC GCT TTC AGT TTT TTA GCG GTG ATT TTA TGC GCT ATT TTA AGC TAT 337Phe Ala Phe Sar Phe Leu Ala Val Ile Leu Cys Ala Ile Leu Ser Tyr
100 105 110CTT GTC CCT AAC GCC AGT AAC GCT CTT TCG CTA ATC GGT AAT GGC GTT 385Leu Val Pro Asn Ala Ser Asn Ala Leu Ser Leu Ile Gly Asn Gly Val
115 120 125TCT ATT TTT TAT TTG CAC AAA CTC TAT AGA GAA TTG AGC CTT TAC ACG 433Ser Ile Phe Tyr Leu His Lys Leu Tyr Arg Glu Leu Ser Leu Tyr Thr
130 135 140CAA GAA AGG TTT TTT TTA AGC GGG TTT AGG TTG TTG CTT TTT AGT TTC 481Gln Glu Arg Phe Phe Leu Ser Gly Phe Arg Leu Leu Leu Phe Ser Phe145 150 155 160ATG CTG GCT CTT TTA GGG ATT TTA GTG CAA GCG TTA GTT ATC ATT TTT 529Met Leu Ala Leu Leu Gly Ile Leu Val Gln Ala Leu Val Ile Ile Phe
165 170 175TTA ACG ACC GCT GTG GTT TTA ATG TGT GTG GCG CTT GGT TTT TTG GCG 577Leu Thr Thr Ala Val Val Leu Met Cys Val Ala Leu Gly Phe Leu Ala
180185 190CGC GCG TTT TTG AAT TTT TCA CAA GTC TTT TTG AAA GCA TGAAAGTTTT AA 628Arg Ala Phe Leu Asn Phe Ser Gln Val Phe Leu Lys Ala
195200205 AACTCCTGCC TAATTT 644 (644) (2) sequence 946 data: (i) sequence characteristics: length (A): 205 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 946: arg Tyr Phe Leu Gln Asn Ile Ile His Ile His Gln Asn Lys Glu Leu 151015 Gln Phe Ile Lys Lys Cys Leu Leu Gly Tyr Phe Phe Ala Pro Leu Cys
20 25 30Gly Ala Ile Leu Leu Val Leu Phe Ile Val Ser Ser Gly Ala Lys Ser
35 40 45Phe Gln Ile Ser Asn Leu Phe Asn Asn Gln Leu Ala Tyr Ile Val Leu
50 55 60Leu Ser Leu Phe Leu Cys Ala Leu Gly Phe Ile Ala Gly Ala Ile Gly65 70 75 80Phe Tyr Arg Leu Ser Lys Ile Thr Arg His Leu Ser Phe Phe Glu Asn
85 90 95Phe Ala Phe Ser Phe Leu Ala Val Ile Leu Cys Ala Ile Leu Ser Tyr
100 105 110Leu Val Pro Asn Ala Ser Asn Ala Leu Ser Leu Ile Gly Asn Gly Val
115 120 125Ser Ile Phe Tyr Leu His Lys Leu Tyr Arg Glu Leu Ser Leu Tyr Thr
130 135 140Gln Glu Arg Phe Phe Leu Ser Gly Phe Arg Leu Leu Leu Phe Ser Phe145 150 155 160Met Leu Ala Leu Leu Gly Ile Leu Val Gln Ala Leu Val Ile Ile Phe
165 170 175Leu Thr Thr Ala Val Val Leu Met Cys Val Ala LeuGly Phe Leu Ala
180 185 190Arg Ala Phe Leu Asn Phe Ser Gln Val Phe Leu Lys Ala
195200205 (2) sequence 947 data: (i) sequence characteristics: length (A): 630bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 598 (D) other information: (xi) Description of the sequence: sequence 947: GTGTGGCGCT TGGTTTTTTG GCGCGCGCGT TTTTGAATTT TTCACAAGTC TTTTTGAAAG 60C ATG AAA GTT TTA AAA CTC CTG CCT AAT TTT TTA ACA ATT TTA CGC ATT 109 Met Lys Val Leu Lys Leu Leu Pro Asn Phe Leu Thr Ile Leu Arg Ile 151015 GTC TTA TCC TTA TTT TTA TTA TTT TTA TTG TTA AAC ACG CGC ACT TAT 157Val Leu Ser Leu Phe Leu Leu Phe Leu Leu Leu Asn Thr Arg Thr Tyr
20 25 30TTT AGT TTT TTA ACC CCC TTT CAA ACC AAT ATG ATC TCT TCA TTG GTT 205Phe Ser Phe Leu Thr Pro Phe Gln Thr Asn Met Ile Ser Ser Leu Val
35 40 45TTT TTG TTT GCC GCG CTC ACG GAT TTA TTG GAC GGC TAC ATC GCT AGA 253Phe Leu Phe Ala Ala Leu Thr Asp Leu Leu Asp Gly Tyr Ile Ala Arg
50 55 60AGC TAT AAA GCC AAA TCG CGC TTT GGG GAA ATC TTT GAT CCT TTA GCG 301Ser Tyr Lys Ala Lys Ser Arg Phe Gly Glu Ile Phe Asp Pro Leu Ala65 70 75 80GAT AAA ATC CTT ATT TTG AGC GCG TTT TTA GGG TTA GTT TAT TTG GAT 349Asp Lys Ile Leu Ile Leu Ser Ala Phe Leu Gly Leu Val Tyr Leu Asp
85 90 95CGT GTG AAT GCG TGG ATC CCG TTT GTG ATT TTA GGG CGT GAA TTT TTT 397Arg Val Asn Ala Trp Ile Pro Phe Val Ile Leu Gly Arg Glu Phe Phe
100 105110ATT TCA GGG CTT AGA GTC TTA GCC GCT AAT GAG AAA AAG GAT ATT CCT 445Ile Ser Gly Leu Arg Val Leu Ala Ala Asn Glu Lys Lys Asp Ile Pro
115 120 125GTC AAT GCG TTA GGC AAG TAT AAA ACC GTT TCT CAA GTC GTG GCG ATT 493Val Asn Ala Leu Gly Lys Tyr Lys Thr Val Ser Gln Val Val Ala Ile
130 135 140GGT GCT TTA TTG GCT GAT GTA ACT TAC TCT TAT GCG CTT GTG GCT ATA 541Gly Ala Leu Leu Ala Asp Val Thr Tyr Ser Tyr Ala Leu Val Ala Ile145 150 155 160GCG GTT TTT TTA ACC CTT TAT TCG GGG ATA GAT TAC ACC ATT AAA TAT 589Ala Val Phe Leu Thr Leu Tyr Ser Gly Ile Asp Tyr Thr Ile Lys Tyr
165170175 TAT AAA TCT TAATATTTTA AAAGAAGTTT TTAGCGTTCT TT 630Tyr Lys Ser (2) sequence 948 data: (i) sequence characteristics: length (A): 179 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 948: met Lys Val Leu Lys Leu Leu Pro Asn Phe Leu Thr Ile Leu Arg Ile 151015 Val Leu Ser Leu Phe Leu Leu Phe Leu Leu Leu Asn Thr Arg Thr Tyr
20 25 30Phe Ser Phe Leu Thr Pro Phe Gln Thr Asn Met Ile Ser Ser Leu Val
35 40 45Phe Leu Phe Ala Ala Leu Thr Asp Leu Leu Asp Gly Tyr Ile Ala Arg
50 55 60Ser Tyr Lys Ala Lys Ser Arg Phe Gly Glu Ile Phe Asp Pro Leu Ala65 70 75 80Asp Lys Ile Leu Ile Leu Ser Ala Phe Leu Gly Leu Val Tyr Leu Asp
85 90 95Arg Val Asn Ala Trp Ile Pro Phe Val Ile Leu Gly Arg Glu Phe Phe
100 105110Ile Ser Gly Leu Arg Val Leu Ala Ala Asn Glu Lys Lys Asp Ile Pro
115 120 125Val Asn Ala Leu Gly Lys Tyr Lys Thr Val Ser Gln Val Val Ala Ile
130 135 140Gly Ala Leu Leu Ala Asp Val Thr Tyr Ser Tyr Ala Leu Val Ala Ile145 150 155 160Ala Val Phe Leu Thr Leu Tyr Ser Gly Ile Asp Tyr Thr Ile Lys Tyr
165170175 Tyr Lys Ser (2) sequence 949 data: (i) sequence characteristics: length (A): 913 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 879 (D) other information: (xi) Description of the sequence: sequence 949: ATAGAAGAAG AGTGAGAA ATG CAA GAT TTT ATT AAG ATT TTT ATT CAA GAG 51
Met Gln Asp Phe Ile Lys Ile Phe Ile Gln Glu
1 5 10GTT GTC TCT ACT TTA GAA GGG TTA GTG GGT AAG GCT CCA AGC GTG GGA 99Val Val Ser Thr Leu Glu Gly Leu Val Gly Lys Ala Pro Ser Val Gly
15 20 25TTA GAA AAA GAA ATT TCT AGT AGC GAC GAA TCT TTT TTG AAA TTA ATC 147Leu Glu Lys Glu Ile Ser Ser Ser Asp Glu Ser Phe Leu Lys Leu Ile
30 35 40AGC ACG CCT TAT GCA AGA GTT GTG ATA AGC GCG ATT GAA AAA GAA GAG 195Ser Thr Pro Tyr Ala Arg Val Val Ile Ser Ala Ile Glu Lys Glu Glu
45 50 55AGC TCT ATT GAA TTA CTG GCT CCG GTA GTT TTA GTT ACC TCT TTA AGC 243Ser Ser Ile Glu Leu Leu Ala Pro Val Val Leu Val Thr Ser Leu Ser60 65 70 75GAT TTG ATG CTA GGA GGT GAG GGA GCGAGT AAG GAA GAA ATG GAT AAT 291Asp Leu Met Leu Gly Gly Glu Gly Ala Ser Lys Glu Glu Met Asp Asn
80 85 90GAC GAT TTA GAC GCT TTT AAA GAA ATG GCT TCT AAT ATT TTT GGC GCG 339Asp Asp Leu Asp Ala Phe Lys Glu Met Ala Ser Asn Ile Phe Gly Ala
95 100 105ATC GCT ACA AGC TTG AAG TCT CAA GAA TTG CTC CCT AAA CTC AAT TTC 387Ile Ala Thr Ser Leu Lys Ser Gln Glu Leu Leu Pro Lys Leu Asn Phe
110 115 120ACC ACT ATA AAC GCT GAA ATC GCT AAA GAG CTT CCT AAA AAA GAA GAT 435Thr Thr Ile Asn Ala Glu Ile Ala Lys Glu Leu Pro Lys Lys Glu Asp
125 130 135TAC GCT AAA GCG ATG GTG TTT TCT TTT AAA ATG GAA GCC ATC AAA GAA 483Tyr Ala Lys Ala Met Val Phe Ser Phe Lys Met Glu Ala Ile Lys Glu140 145 150 155AGC CAA ATC ATT TTA TTG ACT ACG GCG GCT TTT GAG GGC CAA TTT GAA 531Ser Gln Ile Ile Leu Leu Thr Thr Ala Ala Phe Glu Gly Gln Phe Glu
160 165 170AAA ACG CAT AAA GAA GAA AAA GAA GAA ACG ACA GAG GGC GTT GCT GAA 579Lys Thr His Lys Glu Glu Lys Glu Glu Thr Thr Glu Gly Val Ala Glu
175 180 185GAG GTT AAA ACC CAT GAT GCG TCT TTA GAA AAC ATA GAA ATC CGC AAT 627Glu Val Lys Thr His Asp Ala Ser Leu Glu Asn Ile Glu Ile Arg Asn
190 195 200ATC AGC ATG CTT TTA GAC GTG AAA TTG AAC GTT AAG GTG CGC ATC GGG 675Ile Ser Met Leu Leu Asp Val Lys Leu Asn Val Lys Val Arg Ile Gly
205 210 215CAA AAA AAA ATG ATT TTA AAA GAC GTG GTC TCT ATG GAT ATA GGG AGC 723Gln Lys Lys Met Ile LeuLys Asp Val Val Ser Met Asp Ile Gly Ser220 225 230 235GTG GTA GAG CTG GAT CAA TTG GTG AAT GAC CCT TTG GAA ATT CTT GTA 771Val Val Glu Leu Asp Gln Leu Val Asn Asp Pro Leu Glu Ile Leu Val
240 245 250GAT GAC AAG GTG ATC GCT AAG GGC GAA GTG GTG ATT GTG GAT GGG AAT 819Asp Asp Lys Val Ile Ala Lys Gly Glu Val Val Ile Val Asp Gly Asn
255 260 265TTT GGC ATT CAA ATC ACG GAT ATT GGC ACT AAA AAA GAA CGC TTA GAA 867Phe Gly Ile Gln Ile Thr Asp Ile Gly Thr Lys Lys Glu Arg Leu Glu
270 275 280CAA TTG AAA CAT TAAATCTTTT TATCATAAAA AGGAAAGGGA TATG 913Gln Leu Lys His
285 (2) sequence 950 data: (i) sequence characteristics: length (A): 287 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 950: met Gln Asp Phe Ile Lys Ile Phe Ile Gln Glu Val Val Ser Thr Leu 151015 Glu Gly Leu Val Gly Lys Ala Pro Ser Val Gly Leu Glu Lys Glu Ile
20 25 30Ser Ser Ser Asp Glu Ser Phe Leu Lys Leu Ile Ser Thr Pro Tyr Ala
35 40 45Arg Val Val Ile Ser Ala Ile Glu Lys Glu Glu Ser Ser Ile Glu Leu
50 55 60Leu Ala Pro Val Val Leu Val Thr Ser Leu Ser Asp Leu Met Leu Gly65 70 75 80Gly Glu Gly Ala Ser Lys Glu Glu Met Asp Asn Asp Asp Leu Asp Ala
85 90 95Phe Lys Glu Met Ala Ser Asn Ile Phe Gly Ala Ile Ala Thr Ser Leu
100105 110Lys Ser Gln Glu Leu Leu Pro Lys Leu Asn Phe Thr Thr Ile Asn Ala
115 120 125Glu Ile Ala Lys Glu Leu Pro Lys Lys Glu Asp Tyr Ala Lys Ala Met
130 135 140Val Phe Ser Phe Lys Met Glu Ala Ile Lys Glu Ser Gln Ile Ile Leu145 150 155 160Leu Thr Thr Ala Ala Phe Glu Gly Gln Phe Glu Lys Thr His Lys Glu
165 170 175Glu Lys Glu Glu Thr Thr Glu Gly Val Ala Glu Glu Val Lys Thr His
180 185 190Asp Ala Ser Leu Glu Asn Ile Glu Ile Arg Asn Ile Ser Met Leu Leu
195 200 205Asp Val Lys Leu Asn Val Lys Val Arg Ile Gly Gln Lys Lys Met Ile
210 215 220Leu Lys Asp Val Val Ser Met Asp Ile Gly Ser Val Val Glu Leu Asp225 230 235 240Gln Leu Val Asn Asp Pro Leu Glu Ile Leu Val Asp Asp Lys Val Ile
245 250 255Ala Lys Gly Glu Val Val Ile Val Asp Gly Asn Phe Gly Ile Gln Ile
260 265 270Thr Asp Ile Gly Thr Lys Lys Glu Arg Leu Glu Gln Leu Lys His
275280285 (2) sequence 951 materials: (i) sequence characteristics: length (A): 1111 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1056 (D) other information: (xi) Description of the sequence: sequence 951: TAAAAAAGGA GA ATG ATG CAA GTT TAC CAC CTT TCA CAC ATT GAT TTA GAC 51
Met Met Gln Val Tyr His Leu Ser His Ile Asp Leu Asp
1 5 10GGC TAT GCA TGC CAG CTT GTT TCA AAA CAA TTT TTT AAA AAT ATC CAA 99Gly Tyr Ala Cys Gln Leu Val Ser Lys Gln Phe Phe Lys Asn Ile Gln
15 20 25TGC TAT AAC GCT AAT TAC GGG CGT GAA GTC TCA GCG AGA ATT TAT GAG 147Cys Tyr Asn Ala Asn Tyr Gly Arg Glu Val Ser Ala Arg Ile Tyr Glu30 35 40 45ATT TTA AAC GCA ATC GCT CAG TCT AAA GAG AGT GAA TTC CTT ATT TTG 195Ile Leu Asn Ala Ile Ala Gln Ser Lys Glu Ser Glu Phe Leu Ile Leu
50 55 60GTT AGC GAT TTG AAT CTG AAT TTG AAT GAA GCA GAG TAT TTG CAG GAT 243Val Ser Asp Leu Asn Leu Asn Leu Asn Glu Ala Glu Tyr Leu Gln Asp
65 70 75AAG ATC CAA GAA CAC CGC TTG CAA AAT AAA AAC ATT CAA ATC CAG CTT 291Lys Ile Gln Glu His Arg Leu Gln Asn Lys Asn Ile Gln Ile Gln Leu
80 85 90TTA GAT CAC CAT ATC AGC GGT AAG GAA GTG GCT GAG AGT TTC CAT TGG 339Leu Asp His His Ile Ser Gly Lys Glu Val Ala Glu Ser Phe His Trp
95 100 105TAT TTT TTA GAC ATT AAC CGT TGC GCG ACT AAA ATC GTG TAT GAA TTT 387Tyr Phe Leu Asp Ile Asn Arg Cys Ala Thr Lys Ile Val Tyr Glu Phe110 115 120 125TTG AAA AAG CAT TAC GCT ATT TTA GAG CCA AAA AAC ACA ACA TGG CTA 435Leu Lys Lys His Tyr Ala Ile Leu Glu Pro Lys Asn Thr Thr Trp Leu
130 135 140GAG CCT TTA GTG GAA ATG GTC AAT TCT GTG GAT ATT TGG GAC ACG CAA 483Glu Pro Leu Val Glu Met Val Asn Ser Val Asp Ile Trp Asp Thr Gln
145 150 155GGT TAT GGC TTT GAA TTA GGC AAG GTG TGC ATG CGC ATG ATT AAC CAA 531Gly Tyr Gly Phe Glu Leu Gly Lys Val Cys Met Arg Met Ile Asn Gln
160 165 170AGC TCT GAA TTG AAT CGT TTC ATG TTT GAT GAT GAA AAC CGC AAC TAT 579Ser Ser Glu Leu Asn Arg Phe Met Phe Asp Asp Glu Asn Arg Asn Tyr
175 180 185AAA TTA AAG CTT TTA GAA GAA GTT AAA AAC TAT TTG TTT TTA GAA AAT 627Lys Leu Lys Leu Leu Glu Glu Val Lys Asn Tyr Leu Phe Leu Glu Asn190 195 200 205GCC CCT GTA GCC TAT GAT AAC GAT TTG TTC AAA CTC AAA AAA ATC GCT 675Ala Pro Val Ala Tyr Asp Asn Asp Leu Phe Lys Leu Lys Lys Ile Ala
210 215 220TTA GGG GGC GAC CCT GAT GCA GAA ACG ATG GAC AAT ATC TCT TCA AAC 723Leu Gly Gly Asp Pro Asp Ala Glu Thr Met Asp Asn Ile Ser Ser Asn
225 230 235GCG CAA ACG CAT TTG CTC TCT TTA AAA AAG CAT GAT TGC AGC GTT TAT 771Ala Gln Thr His Leu Leu Ser Leu Lys Lys His Asp Cys Ser Val Tyr
240 245 250TAC CAG GAT AAA AAA GGG TTT TTA AGT TAT TCT ATG GGG GGC ATT AGC 819Tyr Gln Asp Lys Lys Gly Phe Leu Ser Tyr Ser Met Gly Gly Ile Ser
255 260 265GTG TTG GCT AAC CTT TTT TTA ACG CAA AAT CCG GAT TTT GAT TTT TAT 867Val Leu Ala Asn Leu Phe Leu Thr Gln Asn Pro Asp Phe Asp Phe Tyr270 275 280 285ATG GAT GTG AAC GCT AAA GGG AAT GTG AGC TTA AGG GCG AAT GGG AAT 915Met Asp Val Asn Ala Lys Gly Asn Val Ser Leu Arg Ala Asn Gly Asn
290 295 300TGC GATGTG TGC GAA CTC AGT CAA ATG TGT TTT AAT GGG GGT GGG CAT 963Cys Asp Val Cys Glu Leu Ser Gln Met Cys Phe Asn Gly Gly Gly His
305 310 315AGG AAT GCG AGC GGA GGC AAG ATT GAT GGT TTT AGG GAG AGT TTC AAT 1011Arg Asn Ala Ser Gly Gly Lys Ile Asp Gly Phe Arg Glu Ser Phe Asn
320 325 330TAT AGG GAT ATT AAA GAA CAA ATT GAA GAA ATC TTC AAC AAC GCT TAAAA 1061Tyr Arg Asp Ile Lys Glu Gln Ile Glu Glu Ile Phe Asn Asn Ala
335340345 CTAAGCTGTT TAGAAAAAAC TAACAAAAAC TGAAAAGAGT TTAAAAGCTC 1111 (1111) (2) sequence 952 data: (i) sequence characteristics: length (A): 348 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 952: met Met Gln Val Tyr His Leu Ser His Ile Asp Leu Asp Gly Tyr Ala 151015 Cys Gln Leu Val Ser Lys Gln Phe Phe Lys Asn Ile Gln Cys Tyr Asn
20 25 30Ala Asn Tyr Gly Arg Glu Val Ser Ala Arg Ile Tyr Glu Ile Leu Asn
35 40 45Ala Ile Ala Gln Ser Lys Glu Ser Glu Phe Leu Ile Leu Val Ser Asp
50 55 60Leu Asn Leu Asn Leu Asn Glu Ala Glu Tyr Leu Gln Asp Lys Ile Gln65 70 75 80Glu His Arg Leu Gln Asn Lys Asn Ile Gln Ile Gln Leu Leu Asp His
85 90 95His Ile Ser Gly Lys Glu Val Ala Glu Ser Phe His Trp Tyr Phe Leu
100 105 110Asp Ile Asn Arg Cys Ala Thr Lys Ile Val Tyr Glu Phe Leu Lys Lys
115 120 125His Tyr Ala Ile Leu Glu Pro Lys Asn Thr Thr Trp Leu Glu Pro Leu
130 135 140Val Glu Met Val Asn Ser Val Asp Ile Trp Asp Thr Gln Gly Tyr Gly145 150 155 160Phe Glu Leu Gly Lys Val Cys Met Arg Met Ile Asn Gln Ser Ser Glu
165 170 175Leu Asn Arg Phe Met Phe Asp Asp Glu Asn Arg Asn Tyr Lys Leu Lys
180 185 190Leu Leu Glu Glu Val Lys Asn Tyr Leu Phe Leu Glu Asn Ala Pro Val
195 200 205Ala Tyr Asp Asn Asp Leu Phe Lys Leu Lys Lys Ile Ala Leu Gly Gly
210 215 220Asp Pro Asp Ala Glu Thr Met Asp Asn Ile Ser Ser Asn Ala Gln Thr225 230 235 240His Leu Leu Ser Leu Lys Lys His Asp Cys Ser Val Tyr Tyr Gln Asp
245 250 255Lys Lys Gly Phe Leu Ser Tyr Ser Met Gly Gly Ile Ser Val Leu Ala
260 265 270Asn Leu Phe Leu Thr Gln Asn Pro Asp Phe Asp Phe Tyr Met Asp Val
275 280 285Asn Ala Lys Gly Asn Val Ser Leu Arg Ala Asn Gly Asn Cys Asp Val
290 295 300Cys Glu Leu Ser Gln Met Cys Phe Asn Gly Gly Gly His Arg Asn Ala305 310 315 320Ser Gly Gly Lys Ile Asp Gly Phe Arg Glu Ser Phe Asn Tyr Arg Asp
325 330 335Ile Lys Glu Gln Ile Glu Glu Ile Phe Asn Asn Ala
340345 (2) sequence 953 data: (i) sequence characteristics: length (A): 2070 bp (B)type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 2024 (D) other information: (xi) Description of the sequence: sequence 953: ATAAAAAATG CGCTTAAAAC CATGAAAAAG GAGATGCG ATG CAA TTA GAC GAA GAT 56
Met Gln Leu Asp Glu Asp
1 5TTA GAA TTC GCT AAA AAA ATC TTT AAC CCT AAC AGA GCG TTT GCC AAG 104Leu Glu Phe Ala Lys Lys Ile Phe Asn Pro Asn Arg Ala Phe Ala Lys
10 15 20CAA GCC AGG ATT AAA AAC ATG TGC GAA TAT AAA GAT TTA GTG CAT GAA 152Gln Ala Arg Ile Lys Asn Met Cys Glu Tyr Lys Asp Leu Val His Glu
25 30 35GCC AAT GAA GAT TAT GAA CAT TTT TGG GGC GAT TTA GCC AAG CAG AAA 200Ala Asn Glu Asp Tyr Glu His Phe Trp Gly Asp Leu Ala Lys Gln Lys
40 45 50CTC ACA TGG TTT AAA CCT TTT GAT AAG GTT TTA AAC AGC GAT AAC GCC 248Leu Thr Trp Phe Lys Pro Phe Asp Lys Val Leu Asn Ser Asp Asn Ala55 60 65 70CCT TTT TTC AAA TGG TTT GAA AAC GGC AAA ATC AAT GTT TCT TAC AAT 296Pro Phe Phe Lys Trp Phe Glu Asn Gly Lys Ile Asn Val Ser Tyr Asn
75 80 85TGC ATA GAC AGG CAT TTA AAA GAC AAA AAA AAT AAA GTG GCG ATC ATT 344Cys Ile Asp Arg His Leu Lys Asp Lys Lys Asn Lys Val Ala Ile Ile
90 95 100TTT GAA GGG GAA ATG GGG GAT TAT AAT GTC ATC ACT TAC AGA AAA CTC 392Phe Glu Gly Glu Met Gly Asp Tyr Asn Val Ile Thr Tyr Arg Lys Leu
105 110 115CAC TCT GAA GTC AAT AAAACA GCC AAC CTT TTA AAA AAC GAA TTC AAT 440His Ser Glu Val Asn Lys Thr Ala Asn Leu Leu Lys Asn Glu Phe Asn
120 125 130GTC AAA AAA GGC GAT AGG GTC ATT ATC TAT ATG CCC ATG ATT GTA GAA 488Val Lys Lys Gly Asp Arg Val Ile Ile Tyr Met Pro Met Ile Val Glu135 140 145 150AGC GTT TAT ATG ATG CTC GCA TGC ACT AGG ATT GGA GCG ATC CAT AGC 536Ser Val Tyr Met Met Leu Ala Cys Thr Arg Ile Gly Ala Ile His Ser
155 160 165ATC GTT TTT GCT GGG TTT AGC CCT GAA GCC TTA AGG GAT AGG ATC AAC 584Ile Val Phe Ala Gly Phe Ser Pro Glu Ala Leu Arg Asp Arg Ile Asn
170 175 180GAC GCT CAA GCT AAA TTA GTT ATC ACA GCG GAT GGG ACT TTT AGA AAA 632Asp Ala Gln Ala Lys Leu Val Ile Thr Ala Asp Gly Thr Phe Arg Lys
185 190 195GGC AAA CCT TAC ATG CTC AAG CCA GCC CTT GAC AAG GCT CTA GAA AAT 680Gly Lys Pro Tyr Met Leu Lys Pro Ala Leu Asp Lys Ala Leu Glu Asn
200 205 210AAC GCC TGC CCT AGC GTG GAA AAA GCG CTC ATT GTG ATA CGA AAC GCC 728Asn Ala Cys Pro Ser Val Glu Lys Ala Leu Ile Val Ile Arg Asn Ala215 220 225 230AAA GAG ATT GAC TAT GTG AGA GGG CGC GAT TTT GTC TAT AAT GAA ATG 776Lys Glu Ile Asp Tyr Val Arg Gly Arg Asp Phe Val Tyr Asn Glu Met
235 240 245GTC AAT TAC CAA TCC GAC AAA TGC GAA CCT GAA ATG ATG GAC TCT GAA 824Val Asn Tyr Gln Ser Asp Lys Cys Glu Pro Glu Met Met Asp Ser Glu
250 255 260GAT CCT TTA TTC TTG CTC TAT ACA AGC GGA TCA ACC GGA AAG CCT AAA 872Asp Pro Leu Phe Leu Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys
265 270 275GGC GTT CAA CAC AGC AGT GCG GGG TAT TTG TTA TGG GCG CAA ATG ACG 920Gly Val Gln His Ser Ser Ala Gly Tyr Leu Leu Trp Ala Gln Met Thr
280 285 290ATG GAG TGG GTT TTT GAT ATT AGA GAT AAC GAT AAT TTT TGG TGC ACC 968Met Glu Trp Val Phe Asp Ile Arg Asp Asn Asp Asn Phe Trp Cys Thr295 300 305 310GCC GAT ATT GGC TGG ATC ACA GGG CAC ACT TAT GTG GTT TAT GGA CCT 1016Ala Asp Ile Gly Trp Ile Thr Gly His Thr Tyr Val Val Tyr Gly Pro
315 320 325TTA GCT TGT GGG GCG ACG ACT TTG ATA CTA GAA GGC ACG ATG TCT TAT 1064Leu Ala Cys Gly Ala Thr Thr Leu Ile Leu Glu Gly Thr Met Ser Tyr
330 335 340CCG GAT TAT GGG AGA TGG TGG AGG ATG ATA GAA GAA TAC CGT GTG GAT 1112Pro Asp Tyr Gly Arg Trp Trp Arg Met Ile Glu Glu Tyr Arg Val Asp
345 350 355AAA TTC TAC ACT TCC CCT ACC GCT ATA AGA ATG TTG CAT GCC AAA GGT 1160Lys Phe Tyr Thr Ser Pro Thr Ala Ile Arg Met Leu His Ala Lys Gly
360 365 370GAA AAC GAA CCC TCA AAG TAT AAT TTA GAG TCG CTC AAA GTT TTA GGA 1208Glu Asn Glu Pro Ser Lys Tyr Asn Leu Glu Ser Leu Lys Val Leu Gly375 380 385 390ACG GTG GGA GAG CCC ATT AAC CCT ACA GCA TGG AAA TGG TTT TAT GAA 1256Thr Val Gly Glu Pro Ile Asn Pro Thr Ala Trp Lys Trp Phe Tyr Glu
395 400 405AAA ATC GGC AAC TCA AAA TGC AGC ATC GTG GAT ACT TGG TGG CAG ACA 1304Lys Ile Gly Asn Ser Lys Cys Ser Ile Val Asp Thr Trp Trp Gln Thr
410415 420GAA ACA GGC GGG CAC ATC ATC AGC CCT TTA CCG GGA GCT ACG CCT ATA 1352Glu Thr Gly Gly His Ile Ile Ser Pro Leu Pro Gly Ala Thr Pro Ile
425 430 435AGG GCC AGT TGC GCG ACT TTA CCT TTG CCT GGA ATC CAT GCG GAA GTT 1400Arg Ala Ser Cys Ala Thr Leu Pro Leu Pro Gly Ile His Ala Glu Val
440 445 450TTA AAC GAA GAC GGC ACT AAA ACA AAG CCT GGA GAG CAA GGG TTT TTA 1448Leu Asn Glu Asp Gly Thr Lys Thr Lys Pro Gly Glu Gln Gly Phe Leu455 460 465 470TGC ATC ACT AAG CCA TGG CCT TCT ATG ATA AGA AAC ATT TGG GGC GAT 1496Cys Ile Thr Lys Pro Trp Pro Ser Met Ile Arg Asn Ile Trp Gly Asp
475 480 485GAA AAA CGA TAC ATT GAT AGC TAT TTT TCT CAG ATC AAG TTG AAT GGG 1544Glu Lys Arg Tyr Ile Asp Ser Tyr Phe Ser Gln Ile Lys Leu Asn Gly
490 495 500GAA TAT GTC TAC CTC TCT GGA GAT GGC GCT ATC GTG GAT GAA AAC GGA 1592Glu Tyr Val Tyr Leu Ser Gly Asp Gly Ala Ile Va1 Asp Glu Asn Gly
505 510 515TAC ATT ACT ATT ATT GGG CGC ACA GAT GAT ATT GTG AAT GTG AGT GGG 1640Tyr Ile Thr Ile Ile Gly Arg Thr Asp Asp Ile Val Asn Val Ser Gly
520 525 530CAT AGG ATT GGC ACG GCT GAA GTG GAG ACC GCT ATT TCC AAG CAT GAA 1688His Arg Ile Gly Thr Ala Glu Val Glu Ser Ala Ile Ser Lys His Glu535 540 545 550ATG GTG GCT GAA TGC GCG GTG GTG GGT ATC CCT GAT GCG ATT AAA GGA 1736Met Val Ala Glu Cys Ala Val Val Gly Ile Pro Asp Ala Ile Lys Gly
555 560 565GAG GGC TTG TTT GCG TTT GTG GTG CTG TGC GAT GGG GCT AAA TGC AAT 1784Glu Gly Leu Phe Ala Phe Val Val Leu Cys Asp Gly Ala Lys Cys Asn
570 575 580CTT GGC GAG AGT TTA GAA TTG CTA AAA GAA ATG AAC CAT ATC TTA TCC 1832Leu Gly Glu Ser Leu Glu Leu Leu Lys Glu Met Asn His Ile Leu Ser
585 590 595ATT GAG ATT GGA AAG ATC GCG AAA TTA GAC AAT GTC ATG TAT GTG CCA 1880Ile Glu Ile Gly Lys Ile Ala Lys Leu Asp Asn Val Met Tyr Val Pro
600 605 610GGT TTG CCT AAA ACC AGG AGC GGG AAA ATC ATG AGA AGG CTT TTG AAA 1928Gly Leu Pro Lys Thr Arg Ser Gly Lys Ile Met Arg Arg Leu Leu Lys615 620 625 630TCC ATC GCC AAA AAA GAG CCT ATC ACT CAA GAT TTA AGC ACG CTA GAA 1976Ser Ile Ala Lys Lys Glu Pro Ile Thr Gln Asp Leu Ser Thr Leu Glu
635 640 645GAT GTG AAT GTG GTT AAA GAA ATA ATG AGC ATC GCT CAA ATG GAG GAG T 2025Asp Val Asn Val Val Lys Glu Ile Met Ser Ile Ala Gln Met Glu Glu
650655660 AAAATCTAAA AAATGCTTTT TAGCGTTTTT TAGCCAAATA ATAAG 2070 (2) sequence 954 data: (i) sequence characteristics: length (A): 662 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 954: met Gln Leu Asp Glu Asp Leu Glu Phe Ala Lys Lys Ile Phe Asn Pro 151015 Asn Arg Ala Phe Ala Lys Gln Ala Arg Ile Lys Asn Met Cys Glu Tyr
20 25 30Lys Asp Leu Val His Glu Ala Asn Glu Asp Tyr Glu His Phe Trp Gly
35 40 45Asp Leu Ala Lys Gln Lys Leu Thr Trp Phe Lys Pro Phe Asp Lys Val
50 55 60Leu Asn Ser Asp Asn Ala Pro Phe Phe Lys Trp Phe Glu Asn Gly Lys65 70 75 80Ile Asn Val Ser Tyr Asn Cys Ile Asp Arg His Leu Lys Asp Lys Lys
85 90 95Asn Lys Val Ala Ile Ile Phe Glu Gly Glu Met Gly Asp Tyr Asn Val
100 105 110Ile Thr Tyr Arg Lys Leu His Ser Glu Val Asn Lys Thr Ala Asn Leu
115 120 125Leu Lys Asn Glu Phe Asn Val Lys Lys Gly Asp Arg Val Ile Ile Tyr
130 135 140Met Pro Met Ile Val Glu Ser Val Tyr Met Met Leu Ala Cys Thr Arg145 150 155 160Ile Gly Ala Ile His Ser Ile Val Phe Ala Gly Phe Ser Pro Glu Ala
165 170 175Leu Arg Asp Arg Ile Asn Asp Ala Gln Ala Lys Leu Val Ile Thr Ala
180 185 190Asp Gly Thr Phe Arg Lys Gly Lys Pro Tyr Met Leu Lys Pro Ala Leu
195 200 205Asp Lys Ala Leu Glu Asn Asn Ala Cys Pro Ser Val Glu Lys Ala Leu
210 215 220Ile Val Ile Arg Asn Ala Lys Glu Ile Asp Tyr Val Arg Gly Arg Asp225 230 235 240Phe Val Tyr Asn Glu Met Val Asn Tyr Gln Ser Asp Lys Cys Glu Pro
245 250 255Glu Met Met Asp Ser Glu Asp Pro Leu Phe Leu Leu Tyr Thr Ser Gly
260 265 270Ser Thr Gly Lys Pro Lys Gly Val Gln His Ser Ser Ala Gly Tyr Leu
275 280 285Leu Trp Ala Gln Met ThrMet Glu Trp Val Phe Asp Ile Arg Asp Asn
290 295 300Asp Asn Phe Trp Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Thr305 310 315 320Tyr Val Val Tyr Gly Pro Leu Ala Cys Gly Ala Thr Thr Leu Ile Leu
325 330 335Glu Gly Thr Met Ser Tyr Pro Asp Tyr Gly Arg Trp Trp Arg Met Ile
340 345 350Glu Glu Tyr Arg Val Asp Lys Phe Tyr Thr Ser Pro Thr Ala Ile Arg
355 360 365Met Leu His Ala Lys Gly Glu Asn Glu Pro Ser Lys Tyr Asn Leu Glu
370 375 380Ser Leu Lys Val Leu Gly Thr Val Gly Glu Pro Ile Asn Pro Thr Ala385 390 395 400Trp Lys Trp Phe Tyr Glu Lys Ile Gly Asn Ser Lys Cys Ser Ile Val
405 410 415Asp Thr Trp Trp Gln Thr Glu Thr Gly Gly His Ile Ile Ser Pro Leu
420 425 430Pro Gly Ala Thr Pro Ile Arg Ala Ser Cys Ala Thr Leu Pro Leu Pro
435 440 445Gly Ile His Ala Glu Val Leu Asn Glu Asp Gly Thr Lys Thr Lys Pro
450 455 460Gly Glu Gln Gly Phe Leu Cys Ile Thr Lys Pro Trp Pro Ser Met Ile465 470 475 480Arg Asn Ile Trp Gly Asp Glu Lys Arg Tyr Ile Asp Ser Tyr Phe Ser
485 490 495Gln Ile Lys Leu Asn Gly Glu Tyr Val Tyr Leu Ser Gly Asp Gly Ala
500 505 510Ile Val Asp Glu Asn Gly Tyr Ile Thr Ile Ile Gly Arg Thr Asp Asp
515 520 525Ile Val Asn Val Ser Gly His Arg Ile Gly Thr Ala Glu Val Glu Ser
530 535 540Ala Ile Ser Lys His Glu Met Val Ala Glu Cys Ala Val Val Gly Ile545 550 555 560Pro Asp Ala Ile Lys Gly Glu Gly Leu Phe Ala Phe Val Val Leu Cys
565 570 575Asp Gly Ala Lys Cys Asn Leu Gly Glu Ser Leu Glu Leu Leu Lys Glu
580 585 590Met Asn His Ile Leu Ser Ile Glu Ile Gly Lys Ile Ala Lys Leu Asp
595 600 605Asn Val Met Tyr Val Pro Gly Leu Pro Lys Thr Arg Ser Gly Lys Ile
610 615 620Met Arg Arg Leu Leu Lys Ser Ile Ala Lys Lys Glu Pro Ile Thr Gln625 630 635 640Asp Leu Ser Thr Leu Glu Asp Val Asn Val Val Lys Glu Ile Met Ser
645 650 655Ile Ala Gln Met Glu Glu
660 (2) sequence 955 data: (i) sequence characteristics: length (A): 725 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 669 (D) other information: (xi) Description of the sequence: sequence 955: TGAATGGCTT AATGAGCA ATG GAT AAA AAC CAA TAT CAC CGC CCC CAT AGA 51
Met Asp Lys Asn Gln Tyr His Arg Pro His Arg
1 5 10GCA AGC CAA ACG GCT TTT AAT GAA AGG ATA GTC ATG TTA AAA ACG AAT 99Ala Ser Gln Thr Ala Phe Asn Glu Arg Ile Val Met LeuLys Thr Asn
15 20 25CAA AAA AAT GTG CAT GCG TTT GAA ATT GAA AAG CAA GAG CCT GAA GCG 147Gln Lys Asn Val His Ala Phe Glu Ile Glu Lys Gln Glu Pro Glu Ala
30 35 40GTC ATA GGG TTT TTA GAA AAA AAC CAT GCC CTT TTG CAA TAT TTT CTT 195Val Ile Gly Phe Leu Glu Lys Asn His Ala Leu Leu Gln Tyr Phe Leu
45 50 55ATT ATT TTT AAA TAC GAT ATT GAA TCA GAA GTC AAA GCC GTT TTG CGC 243Ile Ile Phe Lys Tyr Asp Ile Glu Ser Glu Val Lys Ala Val Leu Arg60 65 70 75AAA CAC CAG CTT TTG TTT TTA GAA ACG AAT CGC GTT TTA AAC GGA CGC 291Lys His Gln Leu Leu Phe Leu Glu Thr Asn Arg Val Leu Asn Gly Arg
80 85 90CAT ATC AAA ACC ATG CCT TTA AAA GAC GAA ACC GAT CAT CCA AAA CCC 339His Ile Lys Thr Met Pro Leu Lys Asp Glu Thr Asp His Pro Lys Pro
95 100 105AAT CAT TCT AAA ACA GAA CCT AAA ACA ACG ATT TAT GAG CGC CAT ATC 387Asn His Ser Lys Thr Glu Pro Lys Thr Thr Ile Tyr Glu Arg His Ile
110 115 120AGG AGT GGG GAA GAG ATT TAT AGC ACT AAT CAC CTT ATT TTT TTG GGT 435Arg Ser Gly Glu Glu Ile Tyr Ser Thr Asn His Leu Ile Phe Leu Gly
125 130 135AAT ATC CAT AAT GGA GCC AAG ATT ATT TCA GAG GGC TGT GTG TCT GTT 483Asn Ile His Asn Gly Ala Lys Ile Ile Ser Glu Gly Cys Val Ser Val140 145 150 155TAT GGG GTT TGC GAA GGG GCG ATT GTG TGC TTT GGA GAG TGT TTG ATC 531Tyr Gly Val Cys Glu Gly Ala Ile Val Cys Phe Gly Glu Cys Leu Ile
160 165170TTA AAA GAA GTC AAG AGC GCT CAA ATC GTT TTT CAA AAC AAA ATT TTG 579Leu Lys Glu Val Lys Ser Ala Gln Ile Val Phe Gln Asn Lys Ile Leu
175 180 185TCT CTA AAA GAG GTT GAA CCG CTT TTG GTA AAT AAA AAT ATT AAA ATA 627Ser Leu Lys Glu Val Glu Pro Leu Leu Val Asn Lys Asn Ile Lys Ile
190 195 200ATC ACT AAA AAT GAC GAT ATA CTA GAC ATA AAG GAA GTA TTA TGAAACAAA 678Ile Thr Lys Asn Asp Asp Ile Leu Asp Ile Lys Glu Val Leu
205 210 215CAACCATTAA CCACTCTGTG GAATTAGTAG GGATAGGCTT GCACAAG 725
(2) Sequence 956 data: (i) sequence characteristics: length (A): 217 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 956: met Asp Lys Asn Gln Tyr His Arg Pro His Arg Ala Ser Gln Thr Ala 151015 Phe Asn Glu Arg Ile Val Met Leu Lys Thr Asn Gln Lys Asn Val His
20 25 30Ala Phe Glu Ile Glu Lys Gln Glu Pro Glu Ala Val Ile Gly Phe Leu
35 40 45Glu Lys Asn His Ala Leu Leu Gln Tyr Phe Leu Ile Ile Phe Lys Tyr
50 55 60Asp Ile Glu Ser Glu Val Lys Ala Val Leu Arg Lys His Gln Leu Leu65 70 75 80Phe Leu Glu Thr Asn Arg Val Leu Asn Gly Arg His Ile Lys Thr Met
85 90 95Pro Leu Lys Asp Glu Thr Asp His Pro Lys Pro Asn His Ser Lys Thr
100 105 110Glu Pro Lys Thr Thr Ile Tyr Glu Arg His Ile Arg Ser Gly Glu Glu
115 120 125Ile Tyr Ser Thr Asn His Leu Ile Phe Leu Gly Asn Ile His Asn Gly
130 135 140Ala Lys Ile Ile Ser Glu Gly Cys Val Ser Val Tyr Gly Val Cys Glu145 150 155 160Gly Ala Ile Val Cys Phe Gly Glu Cys Leu Ile Leu Lys Glu Val Lys
165 170 175Ser Ala Gln Ile Val Phe Gln Asn Lys Ile Leu Ser Leu Lys Glu Val
180 185 190Glu Pro Leu Leu Val Asn Lys Asn Ile Lys Ile Ile Thr Lys Asn Asp
195 200 205Asp Ile Leu Asp Ile Lys Glu Val Leu
210215 (2) sequence 957 data: (i) sequence characteristics: length (A): 1121 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1068 (D) other information: (xi) Description of the sequence: sequence 957: AAAGAAAATC TGGTATTGGA TAAACCCAAG TCTTTAGAAG TGCCTTTGAC TAGGCCCGAA 60ATC ATG GGG CTA GAA GAC AAG TGC CTT TTA TAT GAA ATT AAA GCT AAT 108
Met Gly Leu Glu Asp Lys Cys Leu Leu Tyr Glu Ile Lys Ala Asn
1 5 10 15GAT TGG AGT TAT GCT AAT TTT TTC AAT GGC AAT AAA GCG TCT TTC AAA 156Asp Trp Ser Tyr Ala Asn Phe Phe Asn Gly Asn Lys Ala Ser Phe Lys
20 25 30CAA GAA GTG TGT GTT GAT ACG ATA AAA CCC TCA ATC ACT ATT TTA TCT 204Gln Glu Val Cys Val Asp Thr Ile Lys Pro Ser Ile Thr Ile Leu Ser
35 40 45CGA TCC CCA AGC ATC GCT TAT GGG GGG AGC GCG ATA GTC GTT TTT GAA 252Arg Ser Pro Ser Ile Ala Tyr Gly Gly Ser Ala Ile Val Val Phe Glu
50 55 60GCT TTG GAT AAG AAT TTG TCT CAA GCG TTT GTG CGC GTC AAA AAA AAG 300Ala Leu Asp Lys Asn Leu Ser Gln Ala Phe Val Arg Val Lys Lys Lys
65 70 75GAT TTT GAA GCT TTC AGG CTT TTA GAA TTC AAA CAG CGT AAT GTT TTT 348Asp Phe Glu Ala Phe Arg Leu Leu Glu Phe Lys Gln Arg Asn Val Phe80 85 90 95ATC GCT CTA GTG CCT TGG TCT TAT AAA AAT AAG GAT TTT AAG GCG TTC 396Ile Ala Leu Val Pro Trp Ser Tyr Lys Asn Lys Asp Phe Lys Ala Phe
100 105 110ATT GTC GCT AAA GAT AAA GCC TAT AAC TTT AAT ACC GCC CCT TTA TTG 444Ile Val Ala Lys Asp Lys Ala Tyr Asn Phe Asn Thr Ala Pro Leu Leu
115 120 125TTC AAG CGA AAA ATC CAT CGT TTG AGG GAA AAA GAT ATA GAC TTA AGC 492Phe Lys Arg Lys Ile His Arg Leu Arg Glu Lys Asp Ile Asp Leu Ser
130 135 140GCC TTA AAA GAT AAG ATT GCA AAG CAA GAA AAA TTT CAA AAC GAC ACT 540Ala Leu Lys Asp Lys Ile Ala Lys Gln Glu Lys Phe Gln Asn Asp Thr
145 150 155GAA CAA GCT TTA TTA GAA AGA TTT TCC AAT GCG CGC CCA AAA GAT TTA 588Glu Gln Ala Leu Leu Glu Arg Phe Ser Asn Ala Arg Pro Lys Asp Leu160 165 170 175GAA AAA ATC CAA AAG ATC GCT TTA GAG CAA GGG GAT TTT TAT AAG GAT 636Glu Lys Ile Gln Lys Ile Ala Leu Glu Gln Gly Asp Phe Tyr Lys Asp
180 185 190TTT TCT CAT TTT CAA GCG CTA AAA CCC TTG AAC GGG CCT TTT AAA ATG 684Phe Ser His Phe Gln Ala Leu Lys Pro Leu Asn Gly Pro Phe Lys Met
195 200 205GCA AGC AAT TTT TTA GAA AAT CGG CGT ATC TTA AAG AAT AAT CAG GTG 732Ala Ser Asn Phe Leu Glu Asn Arg Arg Ile Leu Lys Asn Asn Gln Val
210 215 220TTG TTT AAA TTC TTG CAT TTA GGG GTG GAT TTG ATA CCT GGC AAG GAT 780Leu Phe Lys Phe Leu His Leu Gly Val Asp Leu Ile Pro Gly Lys Asp
225 230 235TTA TCT TTA GCG TTT GAT TTG TCT GTG AAG AGG GTT TTT AAG GGG GAG 828Leu Ser Leu Ala Phe Asp Leu Ser Val Lys Arg Val Phe Lys Gly Glu240 245 250 255TTC GAT TTT TAT GGT AAT AGT TTA ATC CAT TGC TAT GGG TTA GGT TTG 876Phe Asp Phe Tyr Gly Asn Ser Leu Ile His Cys Tyr Gly Leu Gly Leu
260 265 270TGC GTT TTT TTA GCC CAT TTA AAA GAT GAT AAA AGC GTG GGG AGT AGT 924Cys Val Phe Leu Ala His Leu Lys Asp Asp Lys Ser Val Gly Ser Ser
275 280 285GGT TTG AAA TTA GGG AGC GGG TTG CAT TTA GGG ATG CTT TTG CAA GGG 972Gly Leu Lys Leu Gly Ser Gly Leu His Leu Gly Met Leu Leu Gln Gly
290 295 300GTT TTT GTC CGG CCC AAT GAA TGG CTT AAT GAG CAA TGG ATA AAA ACC 1020Val Phe Val Arg Pro Asn Glu Trp Leu Asn Glu Gln Trp Ile Lys Thr
305310315 AAT ATC ACC GCC CCC ATA GAG CAA GCC AAA CGG CTT TTA ATG AAA GGA T1069 Asn Ile Thr Ala Pro Ile Glu Gln Ala Lys Arg Leu Leu Met Lys Gly 320325330335 AGTCATGTTA AAAACGAATC AAAAAAATGT GCATGCGTTT GAAATTGAAA AG 1121 (2) sequence 958 data: (i) sequence characteristics: length (A): 335 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 958: met Gly Leu Glu Asp Lys Cys Leu LeuTyr Glu Ile Lys Ala Asn Asp 151015 Trp Ser Tyr Ala Asn Phe Phe Asn Gly Asn Lys Ala Ser Phe Lys Gln
20 25 30Glu Val Cys Val Asp Thr Ile Lys Pro Ser Ile Thr Ile Leu Ser Arg
35 40 45Ser Pro Ser Ile Ala Tyr Gly Gly Ser Ala Ile Val Val Phe Glu Ala
50 55 60Leu Asp Lys Asn Leu Ser Gln Ala Phe Val Arg Val Lys Lys Lys Asp65 70 75 80Phe Glu Ala Phe Arg Leu Leu Glu Phe Lys Gln Arg Asn Val Phe Ile
85 90 95Ala Leu Val Pro Trp Ser Tyr Lys Asn Lys Asp Phe Lys Ala Phe Ile
100 105 110Val Ala Lys Asp Lys Ala Tyr Asn Phe Asn Thr Ala Pro Leu Leu Phe
115 120 125Lys Arg Lys Ile His Arg Leu Arg Glu Lys Asp Ile Asp Leu Ser Ala
130 135 140Leu Lys Asp Lys Ile Ala Lys Gln Glu Lys Phe Gln Asn Asp Thr Glu145 150 155 160Gln Ala Leu Leu Glu Arg Phe Ser Asn Ala Arg Pro Lys Asp Leu Glu
165 170 175Lys Ile Gln Lys Ile Ala Leu Glu Gln Gly Asp Phe Tyr Lys Asp Phe
180 185 190Ser His Phe Gln Ala Leu Lys Pro Leu Asn Gly Pro Phe Lys Met Ala
195 200 205Ser Asn Phe Leu Glu Asn Arg Arg Ile Leu Lys Asn Asn Gln Val Leu
210 215 220Phe Lys Phe Leu His Leu Gly Val Asp Leu Ile Pro Gly Lys Asp Leu225 230235 240Ser Leu Ala Phe Asp Leu Ser Val Lys Arg Val Phe Lys Gly Glu Phe
245 250 255Asp Phe Tyr Gly Asn Ser Leu Ile His Cys Tyr Gly Leu Gly Leu Cys
260 265 270Val Phe Leu Ala His Leu Lys Asp Asp Lys Ser Val Gly Ser Ser Gly
275 280 285Leu Lys Leu Gly Ser Gly Leu His Leu Gly Met Leu Leu Gln Gly Val
290 295 300Phe Val Arg Pro Asn Glu Trp Leu Asn Glu Gln Trp Ile Lys Thr Asn305 310 315 320Ile Thr Ala Pro Ile Glu Gln Ala Lys Arg Leu Leu Met Lys Gly
325330335 (2) sequence 959 data: (i) sequence characteristics: length (A): 1004 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 969 (D) other information: (xi) Description of the sequence: sequence 959: TTACAACTAT TTATTGTAAA GGCTAAA ATG TTG AAA TTT AAA TAT GGT TTG ATT 54
Met Leu Lys Phe Lys Tyr Gly Leu Ile
1 5TAT ATC GCG CTC ATA CTA GGA CTT CAA GCG ACA GAT TAT GAC AAT TTA 102Tyr Ile Ala Leu Tle Leu Gly Leu Gln Ala Thr Asp Tyr Asp Asn Leu10 15 20 25GAA GAA GAA AAC CAA CAA TTA GAT GAA AAA ATA AAC CAT TTA AAG CAA 150Glu Glu Glu Asn Gln Gln Leu Asp Glu Lys Ile Asn His Leu Lys Gln
30 35 40CAG CTC ACC GAA AAA GGG GTT TCG CCC AAA GAG ATG GAT AAG GAT AAG 198Gln Leu Thr Glu Lys Gly Val Ser Pro Lys Glu Met Asp Lys Asp Lys
45 50 55TTT GAA GAA GAA TAC ATC AAT CGA TCT TAT CCT AAA ATT TCT TCC AAG 246Phe Glu Glu Glu Tyr Ile Asn Arg Ser Tyr Pro Lys Ile Ser Ser Lys
60 65 70AAA AAA GAG AAA TTG CTC AAA TCT TTT TCC ATA GCC GAT GAT AAG AGT 294Lys Lys Glu Lys Leu Leu Lys Ser Phe Ser Ile Ala Asp Asp Lys Ser
75 80 85GGG GTT TTT TTA GGG GGT GGG TAT GCT TAT GGG GAA CTT AAC TTG TCT 342Gly Val Phe Leu Gly Gly Gly Tyr Ala Tyr Gly Glu Leu Asn Leu Ser90 95 100 105TAT CAA GGG GAA ATG TTA GAC AGA TAC GGC GCG AAT GCC CCT AGC GCG 390Tyr Gln Gly Glu Met Leu Asp Arg Tyr Gly Ala Asn Ala Pro Ser Ala
110 115 120TTT AAA AAC AAT ATC AAT ATT AAC GCT CCT GTT TCT ATG ATT AGC GCT 438Phe Lys Asn Asn Ile Asn Ile Asn Ala Pro Val Ser Met Ile Ser Ala
125 130 135AAA TTT GGG TAT CAA AAA TAC TTT GTG TCT TAT TTT GGG ACA CGA TTT 486Lys Phe Gly Tyr Gln Lys Tyr Phe Val Ser Tyr Phe Gly Thr Arg Phe
140 145 150TAT GGG GAT TTA TTG CTT GGG GGT GGG GCA TTA AAA GAG GAT GCA ATC 534Tyr Gly Asp Leu Leu Leu Gly Gly Gly Ala Leu Lys Glu Asp Ala Ile
155 160 165AAG CAG CCT GTA GGC TCG TTT ATT TAT GTT TTA GGG GCT GTC AAT ACC 582Lys Gln Pro Val Gly Ser Phe Ile Tyr Val Leu Gly Ala Val Asn Thr170 175 180 185GAT TTA TTG TTT GAT ATG CCT TTA GAT TTT AAA ACT AAA AAG CAT TTT 630Asp Leu Leu Phe Asp Met Pro Leu Asp Phe Lys Thr Lys Lys His Phe
190 195 200TTA GGC GTT TAT GCGGGT TTT GGG ATA GGG CTT ATG CTC TAT CAA GAC 678Leu Gly Val Tyr Ala Gly Phe Gly Ile Gly Leu Met Leu Tyr Gln Asp
205 210 215AGG CCT AAT CAA AAC GGG AGG AAT TTA GTA GTG GGG GGC TAT TCA AGC 726Arg Pro Asn Gln Asn Gly Arg Asn Leu Val Val Gly Gly Tyr Ser Ser
220 225 230CCT AAT TTT TTA TGG AAA TCT TTG ATT GAA GTG GAT TAC ACT TTT AAT 774Pro Asn Phe Leu Trp Lys Ser Leu Ile Glu Val Asp Tyr Thr Phe Asn
235 240 245GTG GGC GTG AGT TTA ACG CTT TAT AGG AAA CAC CGT TTA GAG ATT GGC 822Val Gly Val Ser Leu Thr Leu Tyr Arg Lys His Arg Leu Glu Ile Gly250 255 260 265ACA AAA TTG CCG ATT AGC TAT TTG AGA ATG GGA GTG GAA GAG GGA GCG 870Thr Lys Leu Pro Ile Ser Tyr Leu Arg Met Gly Val Glu Glu Gly Ala
270 275 280ATT TAT CAA AAT AAA GAA GAT GAT GAG CGT TTG TTG GTT TCG GCT AAC 918Ile Tyr Gln Asn Lys Glu Asp Asp Glu Arg Leu Leu Val Ser Ala Asn
285 290 295AAC CAG TTC AAG CGA TCC AGT TTT TTA TTA GTG AAT TAT GCG TTT ATT 966Asn Gln Phe Lys Arg Ser Ser Phe Leu Leu Val Asn Tyr Ala Phe Ile
300305310 TTT TAAGGCTTGA TCTTGGAGTT AAGGTTTAAA ATTTT 1004Phe (2) sequence 960 data: (i) sequence characteristics: length (A): 314 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 960: met Leu Lys Phe Lys Tyr Gly Leu Ile Tyr Ile Ala Leu Ile Leu Gly 151015 Leu Gln Ala Thr Asp Tyr Asp Asn Leu Glu Glu Glu Asn Gln Gln Leu
20 25 30Asp Glu Lys Ile Asn His Leu Lys Gln Gln Leu Thr Glu Lys Gly Val
35 40 45Ser Pro Lys Glu Met Asp Lys Asp Lys Phe Glu Glu Glu Tyr Ile Asn
50 55 60Arg Ser Tyr Pro Lys Ile Ser Ser Lys Lys Lys Glu Lys Leu Leu Lys65 70 75 80Ser Phe Ser Ile Ala Asp Asp Lys Ser Gly Val Phe Leu Gly Gly Gly
85 90 95Tyr Ala Tyr Gly Glu Leu Asn Leu Ser Tyr Gln Gly Glu Met Leu Asp
100 105 110Arg Tyr Gly Ala Asn Ala Pro Ser Ala Phe Lys Asn Asn Ile Asn Ile
115 120 125Asn Ala Pro Val Ser Met Ile Ser Ala Lys Phe Gly Tyr Gln Lys Tyr
130 135 140Phe Val Ser Tyr Phe Gly Thr Arg Phe Tyr Gly Asp Leu Leu Leu Gly145 150 155 160Gly Gly Ala Leu Lys Glu Asp Ala Ile Lys Gln Pro Val Gly Ser Phe
165 170 175Ile Tyr Val Leu Gly Ala Val Asn Thr Asp Leu Leu Phe Asp Met Pro
180 185 190Leu Asp Phe Lys Thr Lys Lys His Phe Leu Gly Val Tyr Ala Gly Phe
195 200 205Gly Ile Gly Leu Met Leu Tyr Gln Asp Arg Pro Asn Gln Asn Gly Arg
210 215 220Asn Leu Val Val Gly Gly Tyr Ser Ser Pro Asn Phe Leu Trp Lys Ser225 230 235 240Leu Ile Glu Val Asp Tyr Thr Phe Asn Val Gly Val Ser Leu Thr Leu
245 250 255Tyr Arg Lys His Arg Leu Glu Ile Gly Thr Lys Leu Pro Ile Ser Tyr
260 265 270Leu Arg Met Gly Val Glu Glu Gly Ala Ile Tyr Gln Asn Lys Glu Asp
275 280 285Asp Glu Arg Leu Leu Val Ser Ala Asn Asn Gln Phe Lys Arg Ser Ser
290 295 300Phe Leu Leu Val Asn Tyr Ala Phe Ile Phe305 310
(2) Sequence 961 data: (i) sequence characteristics:
(A) length: 874 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 18...827
(D) Other information: (xi) sequence description: sequence 961: AACACTTAGG ATTTTTA ATG AGC ATG CAA ACC GCC CCA ATT AAA AAG ATC 50
Met Ser Met Gln Thr Ala Pro Ile Lys Lys Ile
1 5 10ACT CTC AAC CAC CTC CAA GCT AAA AAA AAT CAA GAA AAA ATC ATC GCT 98Thr Leu Asn His Leu Gln Ala Lys Lys Asn Gln Glu Lys Ile Ile Ala
15 20 25ATT ACC GCT TAT GAT GCG CTG TTC GCT CAA ATA TTT GAT CCG CTA GTG 146Ile Thr Ala Tyr Asp Ala Leu Phe Ala Gln Ile Phe Asp Pro Leu Val
30 35 40GAT GTG ATT TTA GTG GGC GAT AGT TTG AAT ATG AGT TTT TTC AAT CAA 194Asp Val Ile Leu Val Gly Asp Ser Leu Asn Met Ser Phe Phe Asn Gln
45 50 55AAC GAC ACT TTA AGC GCG AGT GTG GAA ATG ATG CTC TAT CAC ACC AAA 242Asn Asp Thr Leu Ser Ala Ser Val Glu Met Met Leu Tyr His Thr Lys60 65 70 75GCC GTG TGC GCG GGC GCT AAG ACT CCT TTT ATC ATC ACA GAC ATG CCT 290Ala Val Cys Ala Gly Ala Lys Thr Pro Phe Ile Ile Thr Asp Met Pro
80 85 90TTT GGA AGC TAT AAA GAT GAA AAA ACA GCC CTA AAA AAC GCC ATT AGG 338Phe Gly Ser Tyr Lys Asp Glu Lys Thr Ala Leu Lys Asn Ala Ile Arg
95 100 105GTT TAT AAA GAA ACC CAA GCG AGC GCA ATC AAA TTA GAG GGG GGG AAA 386Val Tyr Lys Glu Thr Gln Ala Ser Ala Ile Lys Leu Glu Gly Gly Lys
110 115 120GAA AAA GCG AAA CTG GTT AAA ACG CTC ACT AAT GAG GGC GTT ATT GTG 434Glu Lys Ala Lys Leu Val Lys Thr Leu Thr Asn Glu Gly Val Ile Val
125 130 135GTA GGG CAT ATT GGC TTG ATG CCC CAA TTC GTG CGC CTT GAT GGA GGT 482Val Gly His Ile Gly Leu Met Pro Gln Phe Val Arg Leu Asp Gly Gly140 145 150 155TAT AAG ATT AAG GGC AAA AAT GAA GAA CAA CAA AAA AAG CTT TTA GAA 530Tyr Lys Ile Lys Gly Lys Asn Glu Glu Gln Gln Lys Lys Leu Leu Glu
160 165 170GAC GCC TTG AGT TTA GAA GAA GCT GGG GTG GGT TTG TTG GTT TTA GAG 578Asp Ala Leu Ser Leu Glu Glu Ala Gly Val Gly Leu Leu Val Leu Glu
175 180 185GGT ATA ACC ACC CCT ATC GCT CAA AAA ATC ACG CAA AAA ATC AAA ATC 626Gly Ile Thr Thr Pro Ile Ala Gln Lys Ile Thr Gln Lys Ile Lys Ile
190 195 200CCC ACG ATC GGC ATA GGG AGC GGT AAA GAT TGC GAT GGG CAG ATT TTA 674Pro Thr Ile Gly Ile Gly Ser Gly Lys Asp Cys Asp Gly GlnIle Leu
205 210 215GTG TGG AGC GAT ATG TTA GGC TTT TTT GAT AGC TTT AAG CCT AAA TTC 722Val Trp Ser Asp Met Leu Gly Phe Phe Asp Ser Phe Lys Pro Lys Phe220 225 230 235GTG CGA GAA TAC CTT AAG GGG AAA GAA TTG ATT CAA AAC GCT ATC AAA 770Val Arg Glu Tyr Leu Lys Gly Lys Glu Leu Ile Gln Asn Ala Ile Lys
240 245 250CAA TAC GCT GAT GAT GTG AAA AAG GGA AAC TTC CCT AAC GAA TTA GAA 818Gln Tyr Ala Asp Asp Val Lys Lys Gly Asn Phe Pro Asn Glu Leu Glu
255 260 265AGT TAT CAT TAATGAAAGA ACGGATAGTC AATTTAGAAA CTTTGGATTT TGAAATT 874Ser Tyr His
270 (2) sequence 962 data: (i) sequence characteristics: length (A): 270 amino acids (B) type: amino acid (C) chain type: single (D) topology: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 962: met Ser Met Gln Thr Ala Pro Ile Lys Lys Ile Thr Leu Asn His Leu 151015 Gln Ala Lys Lys Asn Gln Glu Lys Ile Ile Ala Ile Thr Ala Tyr Asp
20 25 30Ala Leu Phe Ala Gln Ile Phe Asp Pro Leu Val Asp Val Ile Leu Val
35 40 45Gly Asp Ser Leu Asn Met Ser Phe Phe Asn Gln Asn Asp Thr Leu Ser
50 55 60Ala Ser Val Glu Met Met Leu Tyr His Thr Lys Ala Val Cys Ala Gly65 70 75 80Ala Lys Thr Pro Phe Ile Ile Thr Asp Met Pro Phe Gly Ser Tyr Lys
85 90 95Asp Glu Lys Thr Ala Leu Lys Asn Ala Ile Arg Val Tyr Lys Glu Thr
100 105 110Gln Ala Ser Ala Ile Lys Leu Glu Gly Gly Lys Glu Lys Ala Lys Leu
115 120 125Val Lys Thr Leu Thr Asn Glu Gly Val Ile Val Val Gly His Ile Gly
130 135 140Leu Met Pro Gln Phe Val Arg Leu Asp Gly Gly Tyr Lys Ile Lys Gly145 150 155 160Lys Asn Glu Glu Gln Gln Lys Lys Leu Leu Glu Asp Ala Leu Ser Leu
165 170 175Glu Glu Ala Gly Val Gly Leu Leu Val Leu Glu Gly Ile Thr Thr Pro
180 185 190Ile Ala Gln Lys Ile Thr Gln Lys Ile Lys Ile Pro Thr Ile Gly Ile
195 200 205Gly Ser Gly Lys Asp Cys Asp Gly Gln Ile Leu Val Trp Ser Asp Met
210 215 220Leu Gly Phe Phe Asp Ser Phe Lys Pro Lys Phe Val Arg Glu Tyr Leu225 230 235 240Lys Gly Lys Glu Leu Ile Gln Asn Ala Ile Lys Gln Tyr Ala Asp Asp
245 250 255Val Lys Lys Gly Asn Phe Pro Asn Glu Leu Glu Ser Tyr His
260265270 (2) sequence 963 data: (i) sequence characteristics: length (A): 568 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 520 (D) other information: (xi) Description of the sequence: sequence 963: AATAACGATA AAATTTTAAA GGGTGTAAAA GTAGATTGTT ATG TTT GGC ATG GGC 55
Met Phe Gly Met Gly
1 5TTT TTT GAA ATC CTT GTG GTG TTG GTT GTA GCG ATT ATT TTT TTA GGG 103Phe Phe Glu Ile Leu Val Val Leu Val Val Ala Ile Ile Phe Leu Gly
10 15 20CCA GAA AAA TTC CCC CAG GCT GTC GTG GAT GTG GTG AAG TTT TTT CGC 151Pro Glu Lys Phe Pro Gln Ala Val Val Asp Val Val Lys Phe Phe Arg
25 30 35GCG GTT AAA AAA ACG CTC AAT GAC GCT AAG GAC ACT TTA GAT AAA GAA 199Ala Val Lys Lys Thr Leu Asn Asp Ala Lys Asp Thr Leu Asp Lys Glu
40 45 50ATC AAT ATT GAA GAA ATC AAA AAA GAA ACC CTA GAG TAT CAA AAG CTC 247Ile Asn Ile Glu Glu Ile Lys Lys Glu Thr Leu Glu Tyr Gln Lys Leu
55 60 65TTT GAA AAC AAA GTG GAG AGT CTT AAG GGC GTT AAG ATT GAA GAA TTA 295Phe Glu Asn Lys Val Glu Ser Leu Lys Gly Val Lys Ile Glu Glu Leu70 75 80 85GAA GAC GCT AAA GTG ACT GCA GAA AAT GAG ATT AAA AGC ATT CAG GAT 343Glu Asp Ala Lys Val Thr Ala Glu Asn Glu Ile Lys Ser Ile Gln Asp
90 95 100TTG ATG CAA GAT TAC CAA AAA AGC TTA GAA ACC AAC ACA ATC CCT AAC 391Leu Met Gln Asp Tyr Gln Lys Ser Leu Glu Thr Asn Thr Ile Pro Asn
105 110 115CAT TTA AAC GAA GAA GTT TCC AAT GAA GAA GCC TTA AAC AAA GAA GTT 439His Leu Asn Glu Glu Val Ser Asn Glu Glu Ala Leu Asn Lys Glu Val
120 125 130TCA AGC GAT GAA TCC CCT AAA GAA GTC CAA TTA GCA ACC GAT AAC AAC 487Ser Ser Asp Glu Ser Pro Lys Glu Val Gln Leu Ala Thr Asp Asn Asn
135 140 145ACC AAA GAA CAC GAC AAA GAA AAA GAG AAT GTT TGAAGATTTA AAACCGCATT 540Thr Lys Glu His Asp Lys Glu Lys Glu Asn Val150 155 160TACAGGAATT AAGAAAGCGT TTGATGGT 568
(2) Sequence 964 data: (i) sequence characteristics:
(A) length: 160 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein
(xi) Description of the sequence: sequence 964: met Phe Gly Met Gly Phe Phe Glu Ile Leu Val Val Leu Val Val Ala 151015 Ile Ile Phe Leu Gly Pro Glu Lys Phe Pro Gln Ala Val Val Asp Val
20 25 30Val Lys Phe Phe Arg Ala Val Lys Lys Thr Leu Asn Asp Ala Lys Asp
35 40 45Thr Leu Asp Lys Glu Ile Asn Ile Glu Glu Ile Lys Lys Glu Thr Leu
50 55 60Glu Tyr Gln Lys Leu Phe Glu Asn Lys Val Glu Ser Leu Lys Gly Val65 70 75 80Lys Ile Glu Glu Leu Glu Asp Ala Lys Val Thr Ala Glu Asn Glu Ile
85 90 95Lys Ser Ile Gln Asp Leu Met Gln Asp Tyr Gln Lys Ser Leu Glu Thr
100 105 110Asn Thr Ile Pro Asn His Leu Asn Glu Glu Val Ser Asn Glu Glu Ala
115 120 125Leu Asn Lys Glu Val Ser Ser Asp Glu Ser Pro Lys Glu Val Gln Leu
130135140 Ala Thr Asp Asn Asn Thr Lys Glu His Asp Lys Glu Lys Glu Asn Val 145150155160 (2) sequence 965 data: (i) sequence characteristics: length(A): 359 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 46.. 324 (D) other information: (xi) Description of the sequence: sequence 965: TAAAGGCGAG CAGTTAAAAG ATGAAATCGC TTGTAAAGAC ACTGA ATG CTT TAT GCA 57
Met Leu Tyr Ala
1TCA AAA ACG AGT TTA TTT TTA CAA ATC AAA GGA AAG TTT ATG TTA AGA 105Ser Lys Thr Ser Leu Phe Leu Gln Ile Lys Gly Lys Phe Met Leu Arg5 10 15 20ATT TTA ATC CCC TTG CTC ATT ATT GTG TGG GTT TTA TGG CGT TTG TTT 153Ile Leu Ile Pro Leu Leu Ile Ile Val Trp Val Leu Trp Arg Leu Phe
25 30 35TTG AGG CAA AAA CCC CCT AAA GAC AAC CAC TCT TAC ACG CAA CAA ACC 201Leu Arg Gln Lys Pro Pro Lys Asp Asn His Ser Tyr Thr Gln Gln Thr
40 45 50CCT AAA GAA TTA GAA GAT CAC ATG ATT GTA TGC TCT AAA TGC CAA ACC 249Pro Lys Glu Leu Glu Asp His Met Ile Val Cys Ser Lys Cys Gln Thr
55 60 65TAT GTC TCT AGC AAA GAC GCT ATT TAT AGC GGG GCG GTG GCG TAT TGC 297Tyr Val Ser Ser Lys Asp Ala Ile Tyr Ser Gly Ala Val Ala Tyr Cys
707580 AGT GAA ACC TGT TTG AAG GAT AAG AGG TAAATATGCT TATTTTAGGA CACCCTT 351Ser Glu Thr Cys Leu Lys Asp Lys Arg 8590 TAATCCT 359 (2) sequence 966 data: (i) sequence characteristics: length (A): 93 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 966: met Leu Tyr Ala Ser Lys Thr Ser Leu Phe Leu Gln Ile Lys Gly Lys 151015 Phe Met Leu Arg Ile Leu Ile Pro Leu Leu Ile Ile Val TrpVal Leu
20 25 30Trp Arg Leu Phe Leu Arg Gln Lys Pro Pro Lys Asp Asn His Ser Tyr
35 40 45Thr Gln Gln Thr Pro Lys Glu Leu Glu Asp His Met Ile Val Cys Ser
50 55 60Lys Cys Gln Thr Tyr Val Ser Ser Lys Asp Ala Ile Tyr Ser Gly Ala65 70 75 80Val Ala Tyr Cys Ser Glu Thr Cys Leu Lys Asp Lys Arg
85 90
(2) Sequence 967 data: (i) sequence characteristics:
(A) length: 814 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 31...765
(D) Other information: (xi) sequence description: sequence 967: TAAAAAACAA CCAATAAATT AAGGATTATA ATG AAA CCA ACG AAC GAA CCT AAA 54
Met Lys Pro Thr Asn Glu Pro Lys
1 5AAA CCT TTT TTT CAA AGT CCC ATT ATC CTT GCG GTT CTT GGA GGG ATT 102Lys Pro Phe Phe Gln Ser Pro Ile Ile Leu Ala Val Leu Gly Gly Ile
10 15 20TTA CTC ATC TTT TTT CTA CGC TCT TTC AAT TCT GAT GGC AGT TTT TCG 150Leu Leu Ile Phe Phe Leu Arg Ser Phe Asn Ser Asp Gly Ser Phe Ser25 30 35 40GAC AAT TTC TTA GCT TCT AGC ACT AAA AAT GTG AGC TAC CAT GAA ATC 198Asp Asn Phe Leu Ala Ser Ser Thr Lys Asn Val Ser Tyr His Glu Ile
45 50 55AAA CAG CTC ATC AGC AAT AAT GAA GTG GAA AAT GTG AGT ATC GGT CAA 246Lys Gln Leu Ile Ser Asn Asn Glu Val Glu Asn Val Ser Ile Gly Gln
60 65 70ACT TTG ATC AAA GCC AGC CAT AAA GAG GGC AAC AAT CGT GTG ATC TAT 294Thr Leu Ile Lys Ala Ser His Lys Glu Gly Asn Asn Arg Val Ile Tyr
75 80 85ATC GCT AAA CGG GTG CCT GAT TTG ACC TTA GTG CCT TTG TTA GAC GAG 342Ile Ala Lys Arg Val Pro Asp Leu Thr Leu Val Pro Leu Leu Asp Glu
90 95 100AAA AAA ATC AAT TAT TCT GGT TTT AGC GAG TCT AAC TTT TTT ACG GAC 390Lys Lys Ile Asn Tyr Ser Gly Phe Ser Glu Ser Asn Phe Phe Thr Asp105 110 115 120ATG CTA GGG TGG CTC ATG CCT ATT TTA GTG ATT TTA GGG CTA TGG ATG 438Met Leu Gly Trp Leu Met Pro Ile Leu Val Ile Leu Gly Leu Trp Met
125 130 135TTT ATG GCG AAC CGC ATG CAA AAA AAT ATG GGT GGG GGT ATT TTT GGC 486Phe Met Ala Asn Arg Met Gln Lys Asn Met Gly Gly Gly Ile Phe Gly
140 145 150ATG GGG AGC GCG AAA AAA CTC ATT AAC GCT GAA AAA CCC AAT GTG CGT 534Met Gly Ser Ala Lys Lys Leu Ile Asn Ala Glu Lys Pro Asn Val Arg
155 160 165TTT AAT GAC ATG GCA GGC AAT GAA GAA GCC AAA GAA GAA GTG GTA GAA 582Phe Asn Asp Met Ala Gly Asn Glu Glu Ala Lys Glu Glu Val Val Glu
170 175 180ATC GTA GAT TTC TTA AAA TAC CCT GAA CGA TAC GCC AAT TTA GGG GCT 630Ile Val Asp Phe Leu Lys Tyr Pro Glu Arg Tyr Ala Asn Leu Gly Ala185190 195 200AAA ATC CCT AAA GGC GTG TTA TTA GTA GGG CCT CCA GGA ACC GGT AAA 678Lys Ile Pro Lys Gly Val Leu Leu Val Gly Pro Pro Gly Thr Gly Lys
205 210 215ACC CTT TTA GCC AAA GCG GTA GCC GGC GAA CGC ATG TGC CGT TTT TCT 726Thr Leu Leu Ala Lys Ala Val Ala Gly Glu Arg Met Cys Arg Phe Ser
220 225 230CTA TGG GAG GGA GCA GTT TCA TTG AAA TGT TTG TGG GCT TAGGGGCAAG CA 777Leu Trp Glu Gly Ala Val Ser Leu Lys Cys Leu Trp Ala
235240245 GGGTTAGGGA TTTATTTGAA ACCGCTAAAA AACAAGC 814 (814) (2) sequence 968 data: (i) sequence characteristics: length (A): 245 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 968: met Lys Pro Thr Asn Glu Pro Lys Lys Pro Phe Phe Gln Ser Pro Ile 151015 Ile Leu Ala Val Leu Gly Gly Ile Leu Leu Ile Phe Phe Leu Arg Ser
20 25 30Phe Asn Ser Asp Gly Ser Phe Ser Asp Asn Phe Leu Ala Ser Ser Thr
35 40 45Lys Asn Val Ser Tyr His Glu Ile Lys Gln Leu Ile Ser Asn Asn Glu
50 55 60Val Glu Asn Val Ser Ile Gly Gln Thr Leu Ile Lys Ala Ser His Lys65 70 75 80Glu Gly Asn Asn Arg Val Ile Tyr Ile Ala Lys Arg Val Pro Asp Leu
85 90 95Thr Leu Val Pro Leu Leu Asp Glu Lys Lys Ile Asn Tyr Ser Gly Phe
100 105 110Ser Glu Ser Asn Phe Phe Thr Asp Met Leu Gly Trp Leu Met Pro Ile
115 120 125Leu Val Ile Leu Gly Leu Trp Met Phe Met Ala Asn Arg Met Gln Lys
130 135 140Asn Met Gly Gly Gly Ile Phe Gly Met Gly Ser Ala Lys Lys Leu Ile145 150 155 160Asn Ala Glu Lys Pro Asn Val Arg Phe Asn Asp Met Ala Gly Asn Glu
165 170 175Glu Ala Lys Glu Glu Val Val Glu Ile Val Asp Phe Leu Lys Tyr Pro
180 185 190Glu Arg Tyr Ala Asn Leu Gly Ala Lys Ile Pro Lys Gly Val Leu Leu
195 200 205Val Gly Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala Lys Ala Val Ala
210 215 220Gly Glu Arg Met Cys Arg Phe Ser Leu Trp Glu Gly Ala Val Ser Leu225 230 235 240Lys Cys Leu Trp Ala
245 (2) sequence 969 data: (i) sequence characteristics: length (A): 1137 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1093 (D) other information: (xi) Description of the sequence: sequence 969: AAGTGTTTGT ATCGGTTTTA GTGATTTCTT GCCCTTGCGC TTTAGGATTG CTACGCCT 58ATG AGC ATT TTA GTA GCG AAC CAG AAA GCG AGT TCT TTA GGG TTA TTT 106Met Ser Ile Leu Val Ala Asn Gln Lys Ala Ser Ser Leu Gly Leu Phe 151015 TTT AAA GAC GCT AAA AGT TTA GAA AAA GCA AGG CTA GTC AAT ACG ATC 154Phe Lys Asp Ala Lys Ser Leu Glu Lys Ala Arg Leu Val Asn Thr Ile
20 25 30GTT TTT GAT AAA ACC GGC ACG CTC ACT AAC GGC AAG CCT GTC GTT AAA 202Val Phe Asp Lys Thr Gly Thr Leu Thr Asn Gly Lys Pro Val Val Lys
35 40 45AGC GTT CAT TCT AAG ATA GAA TTA TTA GAG TTA TTG AGT TTA GCG CTC 250Ser Val His Ser Lys Ile Glu Leu Leu Glu Leu Leu Ser Leu Ala Leu
50 55 60AGT ATT GAA AAG AGT AGC GAA CAT GTC ATC GCT AAA GGG ATT GTA GAA 298Ser Ile Glu Lys Ser Ser Glu His Val Ile Ala Lys Gly Ile Val Glu65 70 75 80TAC GCA AAA GAG CAT AAC GCT CCC TTA AAA GAA ATG AGC GGG GTT AAA 346Tyr Ala Lys Glu His Asn Ala Pro Leu Lys Glu Mer Ser Gly Val Lys
85 90 95GTG AAA ACG GGT TTT GGC ATT AGT GCT AAA ACA GAT TAT CAA GGC ACT 394Val Lys Thr Gly Phe Gly Ile Ser Ala Lys Thr Asp Tyr Gln Gly Thr
100 105 110AAA GAG ATT ATT AAA GTA GGC AAC AGC GAG TTT TTT AAC CCT ATT AAC 442Lys Glu Ile Ile Lys Val Gly Asn Ser Glu Phe Phe Asn Pro Ile Asn
115 120 125ACG CTA GAA ATT AAA GAA AAC GGG ATT TTA GTG TTT GTT GGT AGA GCG 490Thr Leu Glu Ile Lys Glu Asn Gly Ile Leu Val Phe Val Gly Arg Ala
130 135 140ATC AGT GAA AAA GAA GAC GAG CTT TTA GGG GCG TTT GTT TTA GAA GAT 538Ile Ser Glu Lys Glu Asp Glu Leu Leu Gly Ala Phe Val Leu Glu Asp145 150 155 160TTG CCC AAA AAA GGC GTG AAA GAG CAT ATC GCT CAA ATC AAA AAT TTA 586Leu Pro Lys Lys Gly Val Lys Glu His Ile Ala Gln Ile Lys Asn Leu
165 170 175GGC ATT AAC ACC TTT CTT TTA AGC GGA GAC AAT AGG GAG AAT GTC CAA 634Gly Ile Asn Thr Phe Leu Leu Ser Gly Asp Asn Arg Glu Asn Val Gln
180 185 190AAA TGC GCG TTT GAA TTA GGG ATT GAT GGT TAT ATC AGC AAC GCT AAA682Lys Cys Ala Phe Glu Leu Gly Ile Asp Gly Tyr Ile Ser Asn Ala Lys
195 200 205CCA CAA GAC AAG CTC AAT AAG ATC AAA GAG CTT AAG GAA AAA GGG CAG 730Pro Gln Asp Lys Leu Asn Lys Ile Lys Glu Leu Lys Glu Lys Gly Gln
210 215 220ATC GTT ATG ATG GTG GGC GAT GGC TTG AAT GAC GCT CCT AGT CTT GCT 778Ile Val Met Met Val Gly Asp Gly Leu Asn Asp Ala Pro Ser Leu Ala225 230 235 240ATG AGC GAT GTG GCG GTG GTG ATG GCT AAA GGG AGC GAT GTG AGC GTG 826Met Ser Asp Val Ala Val Val Met Ala Lys Gly Ser Asp Val Ser Val
245 250 255CAA GCA GCG GAC ATT GTG AGT TTT AAT AAC GAT ATT AAA TCG GTT TAT 874Gln Ala Ala Asp Ile Val Ser Phe Asn Asn Asp Ile Lys Ser Val Tyr
260 265 270AGC GCG ATT AAA TTA AGC CAG GCG ACA ATT AAA AAT ATC AAA GAA AAT 922Ser Ala Ile Lys Leu Ser Gln Ala Thr Ile Lys Asn Ile Lys Glu Asn
275 280 285TTG TTT TGG GCT TTT TGT TAT AAT AGC GTG TTC ATC CCT TTA GCT TGT 970Leu Phe Trp Ala Phe Cys Tyr Asn Ser Val Phe Ile Pro Leu Ala Cys
290 295 300GGG GTT CTT TAT AAG GCT AAT CTC ATG TTA AGC CCG GCG ATA GCG GGT 1018Gly Val Leu Tyr Lys Ala Asn Leu Met Leu Ser Pro Ala Ile Ala Gly305 310 315 320TTA GCG ATG AGT TTA AGC TCT GTG AGT GTG GTC TTA AAC TCC CAA AGG 1066Leu Ala Met Ser Leu Ser Ser Val Ser Val Val Leu Asn Ser Gln Arg
325 330 335CTA AGG AAT TTT AAA ATT AAG GAT CAT TGAATGAAAG CAACTTTTCA AGTGCCAAG 1122Leu Arg Asn Phe Lys Ile Lys Asp His
340345 CATTACTTGC AACCA 1137 (2) sequence 970 data: (i) sequence characteristics: length (A): 345 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 970: met Ser Ile Leu Val Ala Asn Gln Lys Ala Ser Ser Leu Gly Leu Phe 151015 Phe Lys Asp Ala Lys Ser Leu Glu Lys Ala Arg Leu Val Asn Thr Ile
20 25 30Val Phe Asp Lys Thr Gly Thr Leu Thr Asn Gly Lys Pro Val Val Lys
35 40 45Ser Val His Ser Lys Ile Glu Leu Leu Glu Leu Leu Ser Leu Ala Leu
50 55 60Ser Ile Glu Lys Ser Ser Glu His Val Ile Ala Lys Gly Ile Val Glu65 70 75 80Tyr Ala Lys Glu His Asn Ala Pro Leu Lys Glu Met Ser Gly Val Lys
85 90 95Val Lys Thr Gly Phe Gly Ile Ser Ala Lys Thr Asp Tyr Gln Gly Thr
100 105 110Lys Glu Ile Ile Lys Val Gly Asn Ser Glu Phe Phe Asn Pro Ile Asn
115 120 125Thr Leu Glu Ile Lys Glu Asn Gly Ile Leu Val Phe Val Gly Arg Ala
130 135 140Ile Ser Glu Lys Glu Asp Glu Leu Leu Gly Ala Phe Val Leu Glu Asp145 150 155 160Leu Pro Lys Lys Gly Val Lys Glu His Ile Ala Gln Ile Lys Asn Leu
165 170 175Gly Ile Asn Thr Phe Leu Leu Ser Gly Asp Asn Arg Glu Asn Val Gln
180 185 190Lys Cys Ala Phe Glu Leu Gly Ile Asp Gly Tyr Ile Ser Asn Ala Lys
195 200 205Pro Gln Asp Lys Leu Asn Lys Ile Lys Glu Leu Lys Glu Lys Gly Gln
210 215 220Ile Val Met Met Val Gly Asp Gly Leu Asn Asp Ala Pro Ser Leu Ala225 230 235 240Met Ser Asp Val Ala Val Val Met Ala Lys Gly Ser Asp Val Ser Val
245 250 255Gln Ala Ala Asp Ile Val Ser Phe Asn Asn Asp Ile Lys Ser Val Tyr
260 265 270Ser Ala Ile Lys Leu Ser Gln Ala Thr Ile Lys Asn Ile Lys Glu Asn
275 280 285Leu Phe Trp Ala Phe Cys Tyr Asn Ser Val Phe Ile Pro Leu Ala Cys
290 295 300Gly Val Leu Tyr Lys Ala Asn Leu Met Leu Ser Pro Ala Ile Ala Gly305 310 315 320Leu Ala Met Ser Leu Ser Ser Val Ser Val Val Leu Asn Ser Gln Arg
325 330 335Leu Arg Asn Phe Lys Ile Lys Asp His
340345 (2) sequence 971 data: (i) sequence characteristics: length (A): 575 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 537 (D) other information: (xi) Description of the sequence: sequence 971: TCAATTCTAT TTAAAAGGTT TTTT ATG GAT ATT TTA AAA ACT CTT CAA AAA 51
Met Asp Ile Leu Lys Thr Leu Gln Lys
1 5CAT TTG GGC GAT GTT GAA ACA AGC GAT TTT ACA ACC AAT GCG ATA GAA 99His Leu Gly Asp Val Glu Thr Ser Asp Phe Thr Thr Asn Ala Ile Glu10 1520 25AAA TCC CAA CAA ATC GCT AAA TTC AGT AGG GAC ATG AAA AAT ATA AAC 147Lys Ser Gln Gln Ile Ala Lys Phe Ser Arg Asp Met Lys Asn Ile Asn
30 35 40GAG AGC GTT GGA GCG TTA CAA GTC TTG CAA ATC GCT TGC AAA AAG CTT 195Glu Ser Val Gly Ala Leu Gln Val Leu Gln Ile Ala Cys Lys Lys Leu
45 50 55TTC AAT AAG AGC ATG GGT TTA GAA GAT AAA GAC GCT TTG CAA GCT TCT 243Phe Asn Lys Ser Met Gly Leu Glu Asp Lys Asp Ala Leu Gln Ala Ser
60 65 70ATC ATC AAA CAG GAA TTG CGA GAA ATT GTA GAA AAT TGC CAG TTT TTA 291Ile Ile Lys Gln Glu Leu Arg Glu Ile Val Glu Asn Cys Gln Phe Leu
75 80 85GCC TCC CCT TTG TTT GAC ACT CAG CTC AAC ATT GCA ATC AAT GAT GAA 339Ala Ser Pro Leu Phe Asp Thr Gln Leu Asn Ile Ala Ile Asn Asp Glu90 95 100 105ATT TTT TCC ATG ATT GTG GTT AAT CCG TTG GAT TTA TTG GAA AAT GTG 387Ile Phe Ser Met Ile Val Val Asn Pro Leu Asp Leu Leu Glu Asn Val
110 115 120GGC GAG TTT CAA GCT TAT TTG GAA GAA AAA TTA AAC GAA ATT AAG GAA 435Gly Glu Phe Gln Ala Tyr Leu Glu Glu Lys Leu Asn Glu Ile Lys Glu
125 130 135TTA TTA GGT TAT TTG AGT GAA AGC CTT TCA AAC CCT AAA GCC TTC ATG 483Leu Leu Gly Tyr Leu Ser Glu Ser Leu Ser Asn Pro Lys Ala Phe Met
140 145 150CCA AGT TTT TCA AAT CAA AGC CTT AAA GAT TTA TTA AGC GAT AAT TTG 531Pro Ser Phe Ser Asn Gln Ser Leu Lys Asp Leu Leu Ser Asp Asn Leu
155160165 AGG GCT TAGAATTCAG CTCTCTAGTT TAGAAAATTT GATTTTCC 575Arg Ala170 (2) sequence 972 data: (i) sequence characteristics: length (A): 171 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 972: met Asp Ile Leu Lys Thr Leu Gln Lys His Leu Gly Asp Val Glu Thr 151015 Ser Asp Phe Thr Thr Asn Ala Ile Glu Lys Ser Gln Gln Ile Ala Lys
20 25 30Phe Ser Arg Asp Met Lys Asn Ile Asn Glu Ser Val Gly Ala Leu Gln
35 40 45Val Leu Gln Ile Ala Cys Lys Lys Leu Phe Asn Lys Ser Met Gly Leu
50 55 60Glu Asp Lys Asp Ala Leu Gln Ala Ser Ile Ile Lys Gln Glu Leu Arg65 70 75 80Glu Ile Val Glu Asn Cys Gln Phe Leu Ala Ser Pro Leu Phe Asp Thr
85 90 95Gln Leu Asn Ile Ala Ile Asn Asp Glu Ile Phe Ser Met Ile Val Val
100 105 110Asn Pro Leu Asp Leu Leu Glu Asn Val Gly Glu Phe Gln Ala Tyr Leu
115 120 125Glu Glu Lys Leu Asn Glu Ile Lys Glu Leu Leu Gly Tyr Leu Ser Glu
130 135 140Ser Leu Ser Asn Pro Lys Ala Phe Met Pro Ser Phe Ser Asn Gln Ser145 150 155 160Leu Lys Asp Leu Leu Ser Asp Asn Leu Arg Ala
165170 (2) sequence 973 data: (i) sequence characteristics: length (A): 1025 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 972 (D) other information: (xi) Description of the sequence: sequence 973: TTTTTAGCGA TTGTGTTCTT GCATGCATTGGGTTTAGCGT TGCTCTTT ATG GCC AAT 57
Met Ala Asn
1AAC GCT TCG TTT TAT GCG GCG GCG TCT ATG GCC TAC ATG CTA GGG GCA 105Asn Ala Ser Phe Tyr Ala Ala Ala Ser Met Ala Tyr Met Leu Gly Ala
5 10 15AAG CAT GCG TTT GAT GCG GAT CAC ATC GCT TGC ATA GAT AAC ACC ATT 153Lys His Ala Phe Asp Ala Asp His Ile Ala Cys Ile Asp Asn Thr Ile20 25 30 35AGA AAG CTC ACC CAA CAA GGC AAA AAC GCC TAT GGT GTG GGG TTT TAC 201Arg Lys Leu Thr Gln Gln Gly Lys Asn Ala Tyr Gly Val Gly Phe Tyr
40 45 50TTT TCT ATG GGG CAT TCA AGC GTG GTG ATT TTA ATG ACC ATC ATC AGC 249Phe Ser Met Gly His Ser Ser Val Val Ile Leu Met Thr Ile Ile Ser
55 60 65GCG TTT GCG ATC GCT TGG GCT AAA GAA CAC ACG CCG ATG CTA GAA GAA 297Ala Phe Ala Ile Ala Trp Ala Lys Glu His Thr Pro Met Leu Glu Glu
70 75 80ATA GGG GGG GTA GTG GGG ACT TTA GTT TCT GGG CTT TTT TTG CTC ATT 345Ile Gly Gly Val Val Gly Thr Leu Val Ser Gly Leu Phe Leu Leu Ile
85 90 95ATA GGG CTA TTG AAT GCG ATT ATT CTC TTG GAT TTA TTA AAA ATA TTC 393Ile Gly Leu Leu Asn Ala Ile Ile Leu Leu Asp Leu Leu Lys Ile Phe100 105 110 115AAA AAA TCG CAC TCT AAT GAA AGC CTA AGC CAG CAA CAA AAT GAA GAG 441Lys Lys Ser His Ser Asn Glu Ser Leu Ser Gln Gln Gln Asn Glu Glu
120 125 130ATC GAG CGG CTC TTA ACG AGT AGG GGC TTG CTC AAC CGC TTT TTT AAA 489Ile Glu Arg LeuLeu Thr Ser Arg Gly Leu Leu Asn Arg Phe Phe Lys
135 140 145CCC TTG TTT AAT TTT GTC TCC AAG TCG TGG CAT ATT TAT CCT ATC GGT 537Pro Leu Phe Asn Phe Val Ser Lys Ser Trp His Ile Tyr Pro Ile Gly
150 155 160TTT CTT TTT GGG CTG GGT TTT GAT ACC GCT AGT GAA ATC GCG CTT TTG 585Phe Leu Phe Gly Leu Gly Phe Asp Thr Ala Ser Glu Ile Ala Leu Leu
165 170 175GCC CTC TCT AGC AGC GCG ATT AAA GTG AGT ATG GTG GGC ATG CTC TCT 633Ala Leu Ser Ser Ser Ala Ile Lys Val Ser Met Val Gly Met Leu Ser180 185 190 195TTA CCC ATT CTT TTT GCC GCT GGC ATG AGT TTG TTT GAC ACT TTA GAT 681Leu Pro Ile Leu Phe Ala Ala Gly Met Ser Leu Phe Asp Thr Leu Asp
200 205 210GGG GCG TTC ATG CTC AAG GCG TAT GAC TGG GCG TTC AAA ACC CCT TTA 729Gly Ala Phe Met Leu Lys Ala Tyr Asp Trp Ala Phe Lys Thr Pro Leu
215 220 225AGA AAA ATC TAT TAC AAT ATC TCT ATC ACG GCC TTA AGC GTG TTT ATC 777Arg Lys Ile Tyr Tyr Asn Ile Ser Ile Thr Ala Leu Ser Val Phe Ile
230 235 240GCG CTC TTT ATT GGC TTG ATT GAG CTT TTT CAA GTC GTT AGC GAG AAA 825Ala Leu Phe Ile Gly Leu Ile Glu Leu Phe Gln Val Val Ser Glu Lys
245 250 255CTC CAT TTA AAA TTT GAA AAC CGC CTT TTA AGA GCC TTA CAA AGC CTG 873Leu His Leu Lys Phe Glu Asn Arg Leu Leu Arg Ala Leu Gln Ser Leu260 265 270 275GAA TTT ACA GAC TTG GGC TAT TAC TTG GTG GGC TTA TTT GTA ATA GCG 921Glu Phe Thr Asp Leu Gly Tyr Tyr Leu Val Gly Leu Phe Val Ile Ala
280 285 290TTT CTA GGA TCG TTC TTT TTA TGG AAA ATC AAA TTT TCT AAA CTA GAG 969Phe Leu Gly Ser Phe Phe Leu Trp Lys Ile Lys Phe Ser Lys Leu Glu
295300305 AGC TGAATTCTAA GCCCTCAAAT TATCGCTTAA TAAATCTTTA AGGCTTTGAT TTG 1025Ser (2) sequence 974 data: (i) sequence characteristics: length (A): 308 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 974: met Ala Asn Asn Ala Ser Phe Tyr Ala Ala Ala Ser Met Ala Tyr Met 151015 Leu Gly Ala Lys His Ala Phe Asp Ala Asp His Ile Ala Cys Ile Asp
20 25 30Asn Thr Ile Arg Lys Leu Thr Gln Gln Gly Lys Asn Ala Tyr Gly Val
35 40 45Gly Phe Tyr Phe Ser Met Gly His Ser Ser Val Val Ile Leu Met Thr
50 55 60Ile Ile Ser Ala Phe Ala Ile Ala Trp Ala Lys Glu His Thr Pro Met65 70 75 80Leu Glu Glu Ile Gly Gly Val Val Gly Thr Leu Val Ser Gly Leu Phe
85 90 95Leu Leu Ile Ile Gly Leu Leu Asn Ala Ile Ile Leu Leu Asp Leu Leu
100 105 110Lys Ile Phe Lys Lys Ser His Ser Asn Glu Ser Leu Ser Gln Gln Gln
115 120 125Asn Glu Glu Ile Glu Arg Leu Leu Thr Ser Arg Gly Leu Leu Asn Arg
130 135 140Phe Phe Lys Pro Leu Phe Asn Phe Val Ser Lys Ser Trp His Ile Tyr145 150 155 160Pro Ile Gly Phe Leu Phe Gly Leu Gly Phe Asp Thr Ala Ser Glu Ile
165 170175Ala Leu Leu Ala Leu Ser Ser Ser Ala Ile Lys Val Ser Met Val Gly
180 185 190Met Leu Ser Leu Pro Ile Leu Phe Ala Ala Gly Met Ser Leu Phe Asp
195 200 205Thr Leu Asp Gly Ala Phe Met Leu Lys Ala Tyr Asp Trp Ala Phe Lys
210 215 220Thr Pro Leu Arg Lys Ile Tyr Tyr Asn Ile Ser Ile Thr Ala Leu Ser225 230 235 240Val Phe Ile Ala Leu Phe Ile Gly Leu Ile Glu Leu Phe Gln Val Val
245 250 255Ser Glu Lys Leu His Leu Lys Phe Glu Asn Arg Leu Leu Arg Ala Leu
260 265 270Gln Ser Leu Glu Phe Thr Asp Leu Gly Tyr Tyr Leu Val Gly Leu Phe
275 280 285Val Ile Ala Phe Leu Gly Ser Phe Phe Leu Trp Lys Ile Lys Phe Ser
290295300 Lys Leu Glu Ser305 (2) sequence 975 data: (i) sequence characteristics: length (A): 1034 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 989(D) other information: (xi) Description of the sequence: sequence 975: TTGTGAAAGA AAATGAAGCG TTTTTTAAAA TCGGTATCAA AAACATCGCC GTGGCTGAAA 60TTTCTTCGCC TTTA ATG GAG TTT TTA GGT TCA ATC GCT ATA GCG CTA GTG 110
Met Glu Phe Leu Gly Ser Ile Ala Ile Ala Leu Val
1 5 10ATT TAT TTA GGG GGG AAT GAA GTG ATT AGA GGC CAT ATT AGC GTG GGG 158Ile Tyr Leu Gly Gly Asn Glu Val Ile Arg Gly His Ile Ser Val Gly
15 2025GCG TTT TTT TCT TTC ATT ACG GCC CTT TTT ATG CTC TAT ACG CCG ATT 206Ala Phe Phe Ser Phe Ile Thr Ala Leu Phe Met Leu Tyr Thr Pro Ile
30 35 40AAA CGC TTA ACT AGG ATT GTT TCT AAT TTT CAA GAA GCC TTA GTC GCT 254Lys Arg Leu Thr Arg Ile Val Ser Asn Phe Gln Glu Ala Leu Val Ala45 50 55 60AGC GAC AGG ATC CAT GAG ATT TTA GAA AGA GAG CCG GCT ATT GTT GAT 302Ser Asp Arg Ile His Glu Ile Leu Glu Arg Glu Pro Ala Ile Val Asp
65 70 75GGG GAA TTG ACG CTA AAT AAC GCC ATA CAC ACC ATA GAA TTT AAA AAG 350Gly Glu Leu Thr Leu Asn Asn Ala Ile His Thr Ile Glu Phe Lys Lys
80 85 90GTA TGG CTG GCT TAT ACG CTA GAC AAT CAA GAG CGT TAT GTT TTA AAC 398Val Trp Leu Ala Tyr Thr Leu Asp Asn Gln Glu Arg Tyr Val Leu Asn
95 100 105GAT ATT AGT TTG AAG TTC CAA CAA AAT GAA ATC ATC GCT TTA AAG GGC 446Asp Ile Ser Leu Lys Phe Gln Gln Asn Glu Ile Ile Ala Leu Lys Gly
110 115 120GAA AGC GGG AGC GGT AAA AGC TCA TTA GTG AAT CTG ATC TTA CGC CTT 494Glu Ser Gly Ser Gly Lys Ser Ser Leu Val Asn Leu Ile Leu Arg Leu125 130 135 140TAT GAG CCA AGC AAA GGC GAA ATT TTC ATC AAC GAT CAA AAA ATA GAG 542Tyr Glu Pro Ser Lys Gly Glu Ile Phe Ile Asn Asp Gln Lys Ile Glu
145 150 155AGC ATC ACT CAA AAA TCC TTA AGA GAA AAG ATT AGC GTT GTC ACT CAA 590Ser Ile Thr Gln Lys Ser Leu Arg Glu Lys Ile Ser Val Val Thr Gln
160 165 170AGG GTG TTT ATT TTT AAC GGG AGC GTG GCT GAA AAT GTG GCG TAT GGT638Arg Val Phe Ile Phe Asn Gly Ser Val Ala Glu Asn Val Ala Tyr Gly
175 180 185TTA GAA ATT GAT GAG GTA AAA ATC AAA GAA TGC CTA AAA AAA GCT CAA 686Leu Glu Ile Asp Glu Val Lys Ile Lys Glu Cys Leu Lys Lys Ala Gln
190 195 200GCC TTA GAT TTT GTT GAA AAA ATG CCT CAT GGG ATA GAG AGC GTT TTA 734Ala Leu Asp Phe Val Glu Lys Met Pro His Gly Ile Glu Ser Val Leu205 210 215 220GAT GAA TTT GGC GCT AAT CTT AGC GGC GGC CAA CGC CAA AGA ATC GCC 782Asp Glu Phe Gly Ala Asn Leu Ser Gly Gly Gln Arg Gln Arg Ile Ala
225 230 235ATT GCA AGA GCT TTG TAT AAA GAC GTT CAA GTT TTA ATC TTT GAT GAA 830Ile Ala Arg Ala Leu Tyr Lys Asp Val Gln Val Leu Ile Phe Asp Glu
240 245 250GCC ACT TCC GCT TTA GAC AAT AAC ACA GAA GAG AGC GTT AAA CAA AGC 878Ala Thr Ser Ala Leu Asp Asn Asn Thr Glu Glu Ser Val Lys Gln Ser
255 260 265ATT TTA GAA TTG AAA CAA AAC CGC TTG ATC ATT CTT ATT TCG CAC AAC 926Ile Leu Glu Leu Lys Gln Asn Arg Leu Ile Ile Leu Ile Ser His Asn
270 275 280CCA AGC ACG CTA AAA TTA GCC ACT AAG CAT GTG AAA TTA GAG CAT GGG 974Pro Ser Thr Leu Lys Leu Ala Thr Lys His Val Lys Leu Glu His Gly285 290 295 300CGT TTG ACA GAA TGC TAAGGGTTTT AAGCGTTGGT GTTGCTTTTA TTTTACTAGG G 1030Arg Leu Thr Glu Cys
305TGTC 1034 (2) sequence 976 data: (i) sequence characteristics: length (A): 305 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 976: met Glu Phe LeuGly Ser Ile Ala Ile Ala Leu Val Ile Tyr Leu Gly 151015 Gly Asn Glu Val Ile Arg Gly His Ile Ser Val Gly Ala Phe Phe Ser
20 25 30Phe Ile Thr Ala Leu Phe Met Leu Tyr Thr Pro Ile Lys Arg Leu Thr
35 40 45Arg Ile Val Ser Asn Phe Gln Glu Ala Leu Val Ala Ser Asp Arg Ile
50 55 60His Glu Ile Leu Glu Arg Glu Pro Ala Ile Val Asp Gly Glu Leu Thr65 70 75 80Leu Asn Asn Ala Ile His Thr Ile Glu Phe Lys Lys Val Trp Leu Ala
85 90 95Tyr Thr Leu Asp Asn Gln Glu Arg Tyr Val Leu Asn Asp Ile Ser Leu
100 105 110Lys Phe Gln Gln Asn Glu Ile Ile Ala Leu Lys Gly Glu Ser Gly Ser
115 120 125Gly Lys Ser Ser Leu Val Asn Leu Ile Leu Arg Leu Tyr Glu Pro Ser
130 135 140Lys Gly Glu Ile Phe Ile Asn Asp Gln Lys Ile Glu Ser Ile Thr Gln145 150 155 160Lys Ser Leu Arg Glu Lys Ile Ser Val Val Thr Gln Arg Val Phe Ile
165 170 175Phe Asn Gly Ser Val Ala Glu Asn Val Ala Tyr Gly Leu Glu Ile Asp
180 185 190Glu Val Lys Ile Lys Glu Cys Leu Lys Lys Ala Gln Ala Leu Asp Phe
195 200 205Val Glu Lys Met Pro His Gly Ile Glu Ser Val Leu Asp Glu Phe Gly
210 215 220Ala Asn Leu Ser Gly Gly Gln Arg Gln Arg Ile Ala Ile Ala Arg Ala225 230235 240Leu Tyr Lys Asp Val Gln Val Leu Ile Phe Asp Glu Ala Thr Ser Ala
245 250 255Leu Asp Asn Asn Thr Glu Glu Ser Val Lys Gln Ser Ile Leu Glu Leu
260 265 270Lys Gln Asn Arg Leu Ile Ile Leu Ile Ser His Asn Pro Ser Thr Leu
275 280 285Lys Leu Ala Thr Lys His Val Lys Leu Glu His Gly Arg Leu Thr Glu
290295300 Cys305 (2) sequence 977 data: (i) sequence characteristics: length (A): 604 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 99...563 (D) other information: (xi) Description of the sequence: sequence 977: TTTTATTTTC TTCTTTAGTG GTGGCTTTAA GCACGGCTTG GGGGACTTAT TTAGTCAAGC 60CCACTTTAGA TGAAATTTTT ATCAATAAAG ACACTCAC ATG CTC AAA ATC CTG CCT 116
Met Leu Lys Ile Leu Pro
1 5TTT TTA GTG ATT TTG GCG TAT TTG GGT AAG AGT GGG GGC ATG TAT TTA 164Phe Leu Val Ile Leu Ala Tyr Leu Gly Lys Ser Gly Gly Met Tyr Leu
10 15 20GGC ACT TAT TTC ACC AAC TTC ATT GGG CTT GAT ATT GTC AAA AAA ATA 212Gly Thr Tyr Phe Thr Asn Phe Ile Gly Leu Asp Ile Val Lys Lys Ile
25 30 35CGC AAC ACT ATG CTA GAA AGC CTT CTT AAA ATG GAA ATG GAT TTT TTT 260Arg Asn Thr Met Leu Glu Ser Leu Leu Lys Met Glu Met Asp Phe Phe
40 45 50AAC AGG ACG AAA AAG GGC GAA TTG ATC GCA AGG ATC ACC AAT GAT ATA 308Asn Arg Thr Lys Lys Gly Glu Leu Ile Ala Arg Ile Thr Asn Asp Ile55 60 65 70GGT TTG ATT AGA GCG AGT TTG TCC AAT TAC CTT TCA GAG AGC ATA AGA 356Gly Leu Ile Arg Ala Ser Leu Ser Asn Tyr Leu Ser Glu Ser Ile Arg
75 80 85GAG GGG CTA ACG ATT GTT GGG TTA GTG GGG GTG GTG ATC TAT CAA AGC 404Glu Gly Leu Thr Ile Val Gly Leu Val Gly Val Val Ile Tyr Gln Ser
90 95 100CCT AAA TTA GCG TTA GTG GGG TTA GTC ATC ATG CCG TTA GCT GCT ATT 452Pro Lys Leu Ala Leu Val Gly Leu Val Ile Met Pro Leu Ala Ala Ile
105 110 115CCT ATC AGT AAA ATC ATT CGT AAG GTT AAA AAA CTC GCT AAA TCC CAT 500Pro Ile Ser Lys Ile Ile Arg Lys Val Lys Lys Leu Ala Lys Ser His
120 125 130CAA GAG AGT AAC GCC AAA ATC ACC GCT CGT TTG AGT GAA GTT TTT AAC 548Gln Glu Ser Asn Ala Lys Ile Thr Ala Arg Leu Ser Glu Val Phe Asn135 140 145 150AAC GTG GGA AGC GAT TAAAATCTCT AATGGCGAAA AATTAGAGCA TAAGGCTTTT G 604Asn Val Gly Ser Asp
155
604
(2) Sequence 978 data: (i) sequence characteristics:
(A) length: 155 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (xi) sequence description: sequence 978:
Met Leu Lys Ile Leu Pro Phe Leu Val Ile Leu Ala Tyr Leu Gly Lys
1 5 10 15Ser Gly Gly Met Tyr Leu Gly Thr Tyr Phe Thr Asn Phe Ile Gly Leu
20 25 30Asp Ile Val Lys Lys Ile Arg Asn Thr Met Leu Glu Ser Leu Leu Lys
35 40 45Met Glu Met Asp Phe Phe Asn Arg Thr Lys Lys Gly Glu Leu Ile Ala
50 55 60Arg Ile Thr Asn Asp Ile Gly Leu Ile Arg Ala Ser Leu Ser Asn Tyr65 70 75 80Leu Ser Glu Ser Ile Arg Glu Gly Leu Thr Ile Val Gly Leu Val Gly
85 90 95Val Val Ile Tyr Gln Ser Pro Lys Leu Ala Leu Val Gly Leu Val Ile
100 105 110Met Pro Leu Ala Ala Ile Pro Ile Ser Lys Ile Ile Arg Lys Val Lys
115 120 125Lys Leu Ala Lys Ser His Gln Glu Ser Asn Ala Lys Ile Thr Ala Arg
130135140 Leu Ser Glu Val Phe Asn Asn Val Gly Ser Asp 145150155 (2) sequence 979 data: (i) sequence characteristics: length (A): 789 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 738 (D) other information: (xi) Description of the sequence: sequence 979: TTTCGCTTAT CAAGTCCCCC TACCTCAATT TTA ATG CGC TTA GAT TAC GCC TTA 54
Met Arg Leu Asp Tyr Ala Leu
1 5TTC AGT CAG CAT TTA GTA AAT AGC AGA GAA AAA GCT AAA GCG TTG GTT 102Phe Ser Gln His Leu Val Asn Ser Arg Glu Lys Ala Lys Ala Leu Val
10 15 20TTA AAA AAT CAG GTTTTA GTC AAT AAA ATG GTG GTT TCC AAA CCC TCT 150Leu Lys Asn Gln Val Leu Val Asn Lys Met Val Val Ser Lys Pro Ser
25 30 35TTT ATA GTG AAA GAG AAC GAT AAA ATT GAA CTC ATC GCT GAA AAA CTT 198Phe Ile Val Lys Glu Asn Asp Lys Ile Glu Leu Ile Ala Glu Lys Leu40 45 50 55TTC GTT AGC AGG GCT GGG GAA AAA TTA GGG GCT TTT TTA GAA ACC CAT 246Phe Val Ser Arg Ala Gly Glu Lys Leu Gly Ala Phe Leu Glu Thr His
60 65 70TTC GTG GAT TTT AAG GGA AAG GTG GTT TTA GAT GTG GGA GCG AGC AAA 294Phe Val Asp Phe Lys Gly Lys Val Val Leu Asp Val Gly Ala Ser Lys
75 80 85GGG GGC TTT AGT CAA GTG GCT CTT TTA AAA GGG GCT AAA AGA GTG CTT 342Gly Gly Phe Ser Gln Val Ala Leu Leu Lys Gly Ala Lys Arg Val Leu
90 95 l00TGC GTG GAT GTG GGG AAA ATG CAA TTA GAT GAA AGT TTG AAA CAA GAC 390Cys Val Asp Val Gly Lys Met Gln Leu Asp Glu Ser Leu Lys Gln Asp
105 110 115AAG CGC ATA GAA TGT TAC GAA GAA TGC GAT ATT AGA GGG TTT AAA ACG 438Lys Arg Ile Glu Cys Tyr Glu Glu Cys Asp Ile Arg Gly Phe Lys Thr120 125 130 135CCA GAA ACA ATT GAT TTA GCG CTT TGC GAT GTG AGC TTT ATT TCT TTA 486Pro Glu Thr Ile Asp Leu Ala Leu Cys Asp Val Ser Phe Ile Ser Leu
140 145 150TAT TAT ATT TTA GAA GCG ATT TTG CCT TTA AGC GAT GAA TTT TTA ACA 534Tyr Tyr Ile Leu Glu Ala Ile Leu Pro Leu Ser Asp Glu Phe Leu Thr
155 160 165CTT TTC AAA CCG CAA TTT GAA GTG GGC AGA GGA ATA AAA CGC AAT AAA 582Leu Phe Lys Pro Gln Phe Glu Val Gly Arg Gly Ile Lys Arg Asn Lys
170 175 180AAA GGG GTG GTG GTG GAT AAA GAA GCC ATT TTG AAC GCT TTA GAA AAC 630Lys Gly Val Val Val Asp Lys Glu Ala Ile Leu Asn Ala Leu Glu Asn
185 190 195TTT AAA AAC CAT TTA AAA ACA AAG GAT TTT CAA ATC TTA AAG ATC CAA 678Phe Lys Asn His Leu Lys Thr Lys Asp Phe Gln Ile Leu Lys Ile Gln200 205 210 215GAA AGC TTA GTG AAA GGG AAA AAC GGG AAT GTT GAA TTT TTT ATC CAT 726Glu Ser Leu Val Lys Gly Lys Asn Gly Asn Val Glu Phe Phe Ile His
220 225 230TTC AAG CGA GCC TAAAATTAAA AGCCTAGCTA TCGGTAAATT TGACGGCTTG CATTT 783Phe Lys Arg Ala
235AGGGCA 789 (2) sequence 980 data: (i) sequence characteristics: length (A): 235 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 980: met Arg Leu Asp Tyr Ala Leu Phe Ser Gln His Leu Val Asn Ser Arg 151015 Glu Lys Ala Lys Ala Leu Val Leu Lys Asn Gln Val Leu Val Asn Lys
20 25 30Met Val Val Ser Lys Pro Ser Phe Ile Val Lys Glu Asn Asp Lys Ile
35 40 45Glu Leu Ile Ala Glu Lys Leu Phe Val Ser Arg Ala Gly Glu Lys Leu
50 55 60Gly Ala Phe Leu Glu Thr His Phe Val Asp Phe Lys Gly Lys Val Val65 70 75 80Leu Asp Val Gly Ala Ser Lys Gly Gly Phe Ser Gln Val Ala Leu Leu
85 90 95Lys Gly Ala Lys Arg Val Leu Cys Val Asp Val Gly Lys Met Gln Leu
100 105110Asp Glu Ser Leu Lys Gln Asp Lys Arg Ile Glu Cys Tyr Glu Glu Cys
115 120 125Asp Ile Arg Gly Phe Lys Thr Pro Glu Thr Ile Asp Leu Ala Leu Cys
130 135 140Asp Val Ser Phe Ile Ser Leu Tyr Tyr Ile Leu Glu Ala Ile Leu Pro145 150 155 160Leu Ser Asp Glu Phe Leu Thr Leu Phe Lys Pro Gln Phe Glu Val Gly
165 170 175Arg Gly Ile Lys Arg Asn Lys Lys Gly Val Val Val Asp Lys Glu Ala
180 185 190Ile Leu Asn Ala Leu Glu Asn Phe Lys Asn His Leu Lys Thr Lys Asp
195 200 205Phe Gln Ile Leu Lys Ile Gln Glu Ser Leu Val Lys Gly Lys Asn Gly
210215220 Asn Val Glu Phe Phe Ile His Phe Lys Arg Ala 225230235 (2) sequence 981 data: (i) sequence characteristics: length (A): 906 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 858 (D) other information: (xi) Description of the sequence: sequence 981: TGAAAGGGAA AAACGGGA ATG TTG AAT TTT TTA TCC ATT TCA AGC GAG CCT 51
Met Leu Asn Phe Leu Ser Ile Ser Ser Glu Pro
1 5 10AAA ATT AAA AGC CTA GCT ATC GGT AAA TTT GAC GGC TTG CAT TTA GGG 99Lys Ile Lys Ser Leu Ala Ile Gly Lys Phe Asp Gly Leu His Leu Gly
15 20 25CAT CAA GCC CTT TTT AAA GAG TTA AAA GAT CCC AAA GCC CTT TTA ATC 147His Gln Ala Leu Phe Lys Glu Leu Lys Asp Pro Lys Ala Leu Leu Ile
30 35 40ATA GAA AAA AAA CAT TAC ACT AAA GGC TAT TTA ACC CCC CTA AAA TAC 195Ile Glu Lys Lys His Tyr Thr Lys Gly Tyr Leu Thr Pro Leu Lys Tyr
45 50 55CGC GCT AAA CTC GTG GGC ATG CCT TTA TTT TTT GTG TAT TTA GAA GAG 243Arg Ala Lys Leu Val Gly Met Pro Leu Phe Phe Val Tyr Leu Glu Glu60 65 70 75ATT TCA CAA TTA AAC GCC CTA GAT TTT TTA GAT CTT TTA AAA AAG AAA 291Ile Ser Gln Leu Asn Ala Leu Asp Phe Leu Asp Leu Leu Lys Lys Lys
80 85 90TTT CCC CAT TTA GAA CGC CTG GTC GTG GGC TAT GAT TTC AGG TTT GGG 339Phe Pro His Leu Glu Arg Leu Val Val Gly Tyr Asp Phe Arg Phe Gly
95 100 105CAT GAG AGG CAA AAT GAC GCT TTA TTT TTA AAA GAG CGT TTT GAA AAA 387His Glu Arg Gln Asn Asp Ala Leu Phe Leu Lys Glu Arg Phe Glu Lys
110 115 120ACC ATT ATT GTG CCT GAA GTG AAA GTC CAA GAG ATT AGC GTG CAT TCT 435Thr Ile Ile Val Pro Glu Val Lys Val Gln Glu Ile Ser Val His Ser
125 130 135AAG ATG ATC AAA CTA GCC CTA AGT CAT GGC GAC TTA TCT TTA GCT AAC 483Lys Met Ile Lys Leu Ala Leu Ser His Gly Asp Leu Ser Leu Ala Asn140 145 150 155AAG CTC TTA GGC AGA CCT TAT GAA GTG TGT GGG GAA GTC ATT AGT GAT 531Lys Leu Leu Gly Arg Pro Tyr Glu Val Cys Gly Glu Val Ile Ser Asp
160 165 170CAA GGT TTG GGG CAT AAA GAA TTA GCA CCC ACT TTA AAT ATA AAA ACT 579Gln Gly Leu Gly His Lys Glu Leu Ala Pro Thr Leu Asn Ile Lys Thr
175 180 185AAA GAT TTT ATC CTC CCT AGT TTTGGG GTG TAT GCG AGT TTA GTG AAA 627Lys Asp Phe Ile Leu Pro Ser Phe Gly Val Tyr Ala Ser Leu Val Lys
190 195 200ATA AAA GAT CCA ATT TAT CAA AAA AGC GTG AGT TTT ATA GGC AAT CGC 675Ile Lys Asp Pro Ile Tyr Gln Lys Ser Val Ser Phe Ile Gly Asn Arg
205 210 215TTA AGC ACG GAT CAA AAT TTC GCC ATA GAA TGC CAT GTC CTT GAT ACC 723Leu Ser Thr Asp Gln Asn Phe Ala Ile Glu Cys His Val Leu Asp Thr220 225 230 235ATC ATA GAA AAC CCG CCC CAA GAA ATC GCT TTG CGT TGG GTT CAA AAA 771Ile Ile Glu Asn Pro Pro Gln Glu Ile Ala Leu Arg Trp Val Gln Lys
240 245 250ATA CGA GAC AAC ATG CGT TTT TCT TCT TTA AAA GAG CTT AAA AAT CAG 819Ile Arg Asp Asn Met Arg Phe Ser Ser Leu Lys Glu Leu Lys Asn Gln
255 260 265ATC CAA CAA GAC ATC TTA AGA GCC AAA GAG ATT TTG AGA TAATTTGTGT TA 870Ile Gln Gln Asp Ile Leu Arg Ala Lys Glu Ile Leu Arg
270275280 AAATGACTCT CAAAAACCTT AAAAATGGAA AAATTT 906 (2) sequence 982 data: (i) sequence characteristics: length (A): 280 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 982: met Leu Asn Phe Leu Ser Ile Ser Ser Glu Pro Lys Ile Lys Ser Leu 151015 Ala Ile Gly Lys Phe Asp Gly Leu His Leu Gly His Gln Ala Leu Phe
20 25 30Lys Glu Leu Lys Asp Pro Lys Ala Leu Leu Ile Ile Glu Lys Lys His
35 40 45Tyr Thr Lys Gly Tyr Leu Thr Pro Leu Lys Tyr Arg Ala Lys Leu Val
50 55 60Gly Met Pro Leu Phe Phe Val Tyr Leu Glu Glu Ile Ser Gln Leu Asn65 70 75 80Ala Leu Asp Phe Leu Asp Leu Leu Lys Lys Lys Phe Pro His Leu Glu
85 90 95Arg Leu Val Val Gly Tyr Asp Phe Arg Phe Gly His Glu Arg Gln Asn
100 105 110Asp Ala Leu Phe Leu Lys Glu Arg Phe Glu Lys Thr Ile Ile Val Pro
115 120 125Glu Val Lys Val Gln Glu Ile Ser Val His Ser Lys Met Ile Lys Leu
130 135 140Ala Leu Ser His Gly Asp Leu Ser Leu Ala Asn Lys Leu Leu Gly Arg145 150 155 160Pro Tyr Glu Val Cys Gly Glu Val Ile Ser Asp Gln Gly Leu Gly His
165 170 175Lys Glu Leu Ala Pro Thr Leu Asn Ile Lys Thr Lys Asp Phe Ile Leu
180 185 190Pro Ser Phe Gly Val Tyr Ala Ser Leu Val Lys Ile Lys Asp Pro Ile
195 200 205Tyr Gln Lys Ser Val Ser Phe Ile Gly Asn Arg Leu Ser Thr Asp Gln
210 215 220Asn Phe Ala Ile Glu Cys His Val Leu Asp Thr Ile Ile Glu Asn Pro225 230 235 240Pro Gln Glu Ile Ala Leu Arg Trp Val Gln Lys Ile Arg Asp Asn Met
245 250 255Arg Phe Ser Ser Leu Lys Glu Leu Lys Asn Gln Ile Gln Gln Asp Ile
260 265 270Leu Arg Ala Lys Glu Ile Leu Arg
275 280
(2) Sequence 983 data: (i) sequencecharacteristics:
(A) length: 2627 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: genomic DNA (ix) characteristics:
(A) name/keyword: coding sequence
(B) Position: 18...2582
(D) Other information: (xi) sequence description: sequence 983: AAAGACATGT GCAACCG ATG AAA TCT AAA AAA CTT TAT TTG GCT TTA ATC 50
Met Lys Ser Lys Lys Leu Tyr Leu Ala Leu Ile
1 5 10ATA GGG GTT TTA TTA GCG TTT TTA ACC CTA TCT TCA TGG CTG GGT AAT 98Ile Gly Val Leu Leu Ala Phe Leu Thr Leu Ser Ser Trp Leu Gly Asn
15 20 25AGC GGT TTA GTG GGG CGT TTT GGG GTG TGG TTT GCC GCA CTC AAT AAA 146Ser Gly Leu Val Gly Arg Phe Gly Val Trp Phe Ala Ala Leu Asn Lys
30 35 40AAA TAT TTT GGG CAT CTT TCA TTC ATT AAT TTA CCC TAT TTA GCA TGG 194Lys Tyr Phe Gly His Leu Ser Phe Ile Asn Leu Pro Tyr Leu Ala Trp
45 50 55GTT TTA TTC CTT TTA TAC AAG ACT AAA AAC CCT TTT ACA GAA ATC GTT 242Val Leu Phe Leu Leu Tyr Lys Thr Lys Asn Pro Phe Thr Glu Ile Val60 65 70 75TTA GAA AAA ACT TTA GGG CAT CTA TTA GGC ATT TTA TCT TTG CTC TTT 290Leu Glu Lys Thr Leu Gly His Leu Leu Gly Ile Leu Ser Leu Leu Phe
80 85 90TTA CAA TCT AGC CTA TTA AAT CAA GGG GAA ATC GGC AAC AGC GCG CGT 338Leu Gln Ser Ser Leu Leu Asn Gln Gly Glu Ile Gly Asn Ser Ala Arg
95 100 105TTG TTT TTA CGC CCT TTT ATA GGG GAT TTT GGG CTT TAT GCG CTG ATA 386Leu Phe Leu Arg Pro Phe Ile Gly Asp Phe Gly Leu Tyr Ala Leu Ile
110 115 120ACG CTT ATG GTA GTT ATT TCT TAT TTG ATT CTA TTC AAA CTA CCC CCT 434Thr Leu Met Val Val Ile Ser Tyr Leu Ile Leu Phe Lys Leu Pro Pro
125 130 135AAA AGC GTT TTT TAT CCT TAT ATG AAC AAA ACA CAA AAC CTT TTA AAA 482Lys Ser Val Phe Tyr Pro Tyr Met Asn Lys Thr Gln Asn Leu Leu Lys140 145 150 155GAG ATT TAC AAA CAA TGC TTA CAA GCC TTT AGC CCT AAT TTT AGC CCA 530Glu Ile Tyr Lys Gln Cys Leu Gln Ala Phe Ser Pro Asn Phe Ser Pro
160 165 170AAA AAA GAG GGT TTT GAA AAC ACC CCA TCA GAT ATT CAA AAA AAA GAA 578Lys Lys Glu Gly Phe Glu Asn Thr Pro Ser Asp Ile Gln Lys Lys Glu
175 180 185ACC AAA AAC GAC AAA GAA AAA GAA AAC CGC AAA GAA AAC CCT ATT AAT 626Thr Lys Asn Asp Lys Glu Lys Glu Asn Arg Lys Glu Asn Pro Ile Asn
190 195 200GAA AAC CAC AAA ACC CCT AAC GAA GAA CCG TTT TTA GCG ATC CCT ACC 674Glu Asn His Lys Thr Pro Asn Glu Glu Pro Phe Leu Ala Ile Pro Thr
205 210 215CCC TAT AAC ACG ACT TTA AAT GAT TCA GAG CCG CAA GAA GGC TTA GTC 722Pro Tyr Asn Thr Thr Leu Asn Asp Ser Glu Pro Gln Glu Gly Leu Val220 225 230 235CAA ATT TCC TCC CAC CCC CCT ACC CAT TAC ACC ATT TAC CCT AAA AGA 770Gln Ile Ser Ser His Pro Pro Thr His Tyr Thr Ile Tyr Pro Lys Arg
240 245250AAC CGA TTT GAT GAT TTG ACT AAC CCC ACT AAC CCC CCT TTA AAA GAA 818Asn Arg Phe Asp Asp Leu Thr Asn Pro Thr Asn Pro Pro Leu Lys Glu
255 260 265ATT AAA CAA GAA ACT AAA GAA AGA GAA CCC ACG CCT ACA AAA GAA ACT 866Ile Lys Gln Glu Thr Lys Glu Arg Glu Pro Thr Pro Thr Lys Glu Thr
270 275 280CTT ACG CCC ACC ACG CCC AAA CCT ATC ATG CCC ACA CTT GCA CCC ATA 914Leu Thr Pro Thr Thr Pro Lys Pro Ile Met Pro Thr Leu Ala Pro Ile
285 290 295ATA GAA AAT GAC AAC AAA ACA GAA AAC CAA AAA ACC CCC AAC CAC CCT 962Ile Glu Asn Asp Asn Lys Thr Glu Asn Gln Lys Thr Pro Asn His Pro300 305 310 315AAA AAA GAA GAA AAC CCA CAA GAA AAC ACG CAA GAA GAA ATG ATA GAA 1010Lys Lys Glu Glu Asn Pro Gln Glu Asn Thr Gln Glu Glu Met Ile Glu
320 325 330GGA AGG ATA GAA GAA ATG ATA AAG GAA AAT CTA AAA AAA GAA GAA AAA 1058Gly Arg Ile Glu Glu Met Ile Lys Glu Asn Leu Lys Lys Glu Glu Lys
335 340 345GAA GTG CAA AAC GCT CCA AAC TTT AGC CCA GTA ACC CCC ACA AGC GCT 1106Glu Val Gln Asn Ala Pro Asn Phe Ser Pro Val Thr Pro Thr Ser Ala
350 355 360AAA AAA CCC GTT ATG GTT AAA GAA TTG AGC GAA AAT AAA GAG ATA TTA 1154Lys Lys Pro Val Met Val Lys Glu Leu Ser Glu Asn Lys Glu Ile Leu
365 370 375GAC GGA TTG GAT TAT GGC GAA GTG CAA AAA CCC AAA GAT TAT GAG CTT 1202Asp Gly Leu Asp Tyr Gly Glu Val Gln Lys Pro Lys Asp Tyr Glu Leu380 385 390 395CCC ACC ACG CAA TTA TTG AAT GCG GTT TGT TTG AAA GAC ACT TCT TTA 1250Pro Thr Thr Gln Leu Leu Asn Ala Val Cys Leu Lys Asp Thr Ser Leu
400 405 410GAC GAA AAC GAG ATT GAC CAA AAA ATC CAG GAT CTA TTG AGC AAA CTG 1298Asp Glu Asn Glu Ile Asp Gln Lys Ile Gln Asp Leu Leu Ser Lys Leu
415 420 425CGC ACC TTT AAA ATT GAT GGC GAT ATT ATC CGC ACT TAT TCA GGC CCT 1346Arg Thr Phe Lys Ile Asp Gly Asp Ile Ile Arg Thr Tyr Ser Gly Pro
430 435 440ATT GTA ACC ACT TTT GAA TTC CGC CCA GCC CCT AAC GTT AAG GTG AGT 1394Ile Val Thr Thr Phe Glu Phe Arg Pro Ala Pro Asn Val Lys Val Ser
445 450 455CGT ATT TTA GGC TTG AGC GAT GAT TTA GCG ATG ACT TTA TGC GCT GAA 1442Arg Ile Leu Gly Leu Ser Asp Asp Leu Ala Met Thr Leu Cys Ala Glu460 465 470 475TCC ATC CGC ATT CAA GCC CCT ATT AAG GGT AAA GAT GTC GTT GGC ATT 1490Ser Ile Arg Ile Gln Ala Pro Ile Lys Gly Lys Asp Val Val Gly Ile
480 485 490GAA ATC CCT AAC AGC CAA AGC CAA ATT ATT TAT TTA AGA GAA ATT CTA 1538Glu Ile Pro Asn Ser Gln Ser Gln Ile Ile Tyr Leu Arg Glu Ile Leu
495 500 505GAG AGC GAA TTG TTT CAA AAA TCC AGC TCG CCC TTA ACT CTA GCT TTA 1586Glu Ser Glu Leu Phe Gln Lys Ser Ser Ser Pro Leu Thr Leu Ala Leu
510 515 520GGC AAA GAC ATT GTG GGT AAC CCT TTC ATC ACG GAT TTA AAA AAG CTC 1634Gly Lys Asp Ile Val Gly Asn Pro Phe Ile Thr Asp Leu Lys Lys Leu
525 530 535CCC CAT TTG CTC ATC GCT GGC ACG ACA GGA AGC GGT AAG AGC GTG GGC 1682Pro His Leu Leu Ile Ala Gly Thr Thr Gly Ser Gly Lys Ser Val Gly540545 550 555GTG AAT GCG ATG ATT TTA TCC TTA CTT TAT AAA AAC CCT CCC GAT CAA 1730Val Asn Ala Met Ile Leu Ser Leu Leu Tyr Lys Asn Pro Pro Asp Gln
560 565 570CTC AAA TTA GTG ATG ATC GAT CCC AAA ATG GTA GAA TTT AGT ATT TAT 1778Leu Lys Leu Val Met Ile Asp Pro Lys Met Val Glu Phe Ser Ile Tyr
575 580 585GCG GAT ATC CCT CAT TTG CTC ACG CCC ATT ATC ACC GAC CCT AAA AAA 1826Ala Asp Ile Pro His Leu Leu Thr Pro Ile Ile Thr Asp Pro Lys Lys
590 595 600GCT ATT GGG GCT TTG CAA AGC GTG GCT AAA GAA ATG GAA CGC CGG TAT 1874Ala Ile Gly Ala Leu Gln Ser Val Ala Lys Glu Met Glu Arg Arg Tyr
605 610 615TCT TTA ATG AGC GAA TAC AAG GTT AAA ACC ATT GAT TCT TAT AAT GAA 1922Ser Leu Met Ser Glu Tyr Lys Val Lys Thr Ile Asp Ser Tyr Asn Glu620 625 630 635CAA GCC CCA AGT AAC GGC GTT GAA GCG TTC CCC TAT TTG ATT GTG GTG 1970Gln Ala Pro Ser Asn Gly Val Glu Ala Phe Pro Tyr Leu Ile Val Val
640 645 650ATT GAT GAA TTA GCG GAT TTA ATG ATG ACA GGG GGC AAA GAA GCG GAG 2018Ile Asp Glu Leu Ala Asp Leu Met Met Thr Gly Gly Lys Glu Ala Glu
655 660 665TTT CCT ATC GCT AGA ATC GCT CAA ATG GGG CGC GCG AGC GGC TTA CAC 2066Phe Pro Ile Ala Arg Ile Ala Gln Met Gly Arg Ala Ser Gly Leu His
670 675 680CTC ATT GTA GCG ACC CAA CGC CCA AGC GTG GAT GTC GTA ACC GGC TTG 2114Leu Ile Val Ala Thr Gln Arg Pro Ser Val Asp Val Val Thr Gly Leu
685 690 695ATT AAA ACC AAC TTG CCTTCA AGG GTG AGT TTT AGG GTA GGC ACT AAG 2162Ile Lys Thr Asn Leu Pro Ser Arg Val Ser Phe Arg Val Gly Thr Lys700 705 710 715ATT GAT TCT AAA GTG ATT TTA GAC ACT GAT GGG GCG CAA AGC TTG TTA 2210Ile Asp Ser Lys Val Ile Leu Asp Thr Asp Gly Ala Gln Ser Leu Leu
720 725 730GGA AGA GGC GAT ATG CTC TTT ACC CCC CCA GGA GCG AAC GGG TTA GTG 2258Gly Arg Gly Asp Met Leu Phe Thr Pro Pro Gly Ala Asn Gly Leu Val
735 740 745CGC TTG CAT GCC CCC TTT GCC ACT GAA GAT GAA ATC AAA AAA ATC GTG 2306Arg Leu His Ala Pro Phe Ala Thr Glu Asp Glu Ile Lys Lys Ile Val
750 755 760GAT TTT ATT AAA GCC CAA AAA GAA GTA CAA TAC GAT AAA GAT TTC TTG 2354Asp Phe Ile Lys Ala Gln Lys Glu Val Gln Tyr Asp Lys Asp Phe Leu
765 770 775CTA GAA GAA TCA CGC ATG CCT TTA GAC ACC CCT AAT TAT CAA GGC GAT 2402Leu Glu Glu Ser Arg Met Pro Leu Asp Thr Pro Asn Tyr Gln Gly Asp780 785 790 795GAC ATT TTA GAA AGG GCT AAA GCG GTG ATT TTA GAA AAA AAG ATC ACT 2450Asp Ile Leu Glu Arg Ala Lys Ala Val Ile Leu Glu Lys Lys Ile Thr
800 805 810TCT ACG AGT TTT TTA CAA CGC CAA TTA AAA ATC GGC TAC AAC CAA GCC 2498Ser Thr Ser Phe Leu Gln Arg Gln Leu Lys Ile Gly Tyr Asn Gln Ala
815 820 825GCT ACC ATT ACT GAC GAA TTA GAA GCT CAA GGC TTT TTA TCC CCA AGA 2546Ala Thr Ile Thr Asp Glu Leu Glu Ala Gln Gly Phe Leu Ser Pro Arg
830 835 840AAC GCT AAA GGC AAC AGA GAG ATT TTG CAA AAC TTT TAGGCTTTGT TTTCAT 2598Asn Ala Lys Gly Asn Arg GluIle Leu Gln Asn Phe
845850855 TGGATATTGG CAAACATTAT TTTTGATTT 2627 (2) sequence 984 data: (i) sequence characteristics: length (A): 855 amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 984: met Lys Ser Lys Lys Leu Tyr Leu Ala Leu Ile Ile Gly Val Leu Leu 151015 Ala Phe Leu Thr Leu Ser Ser Trp Leu Gly Asn Ser Gly Leu Val Gly
20 25 30Arg Phe Gly Val Trp Phe Ala Ala Leu Asn Lys Lys Tyr Phe Gly His
35 40 45Leu Ser Phe Ile Asn Leu Pro Tyr Leu Ala Trp Val Leu Phe Leu Leu
50 55 60Tyr Lys Thr Lys Asn Pro Phe Thr Glu Ile Val Leu Glu Lys Thr Leu65 70 75 80Gly His Leu Leu Gly Ile Leu Ser Leu Leu Phe Leu Gln Ser Ser Leu
85 90 95Leu Asn Gln Gly Glu Ile Gly Asn Ser Ala Arg Leu Phe Leu Arg Pro
100 105 110Phe Ile Gly Asp Phe Gly Leu Tyr Ala Leu Ile Thr Leu Met Val Val
115 120 125Ile Ser Tyr Leu Ile Leu Phe Lys Leu Pro Pro Lys Ser Val Phe Tyr
130 135 140Pro Tyr Met Asn Lys Thr Gln Asn Leu Leu Lys Glu Ile Tyr Lys Gln145 150 155 160Cys Leu Gln Ala Phe Ser Pro Asn Phe Ser Pro Lys Lys Glu Gly Phe
165 170 175Glu Asn Thy Pro Ser Asp Ile Gln Lys Lys Glu Thr Lys Asn Asp Lys
180 185 190Glu Lys Glu Asn Arg Lys Glu AsnPro Ile Asn Glu Asn His Lys Thr
195 200 205Pro Asn Glu Glu Pro Phe Leu Ala Ile Pro Thr Pro Tyr Asn Thr Thr
210 215 220Leu Asn Asp Ser Glu Pro Gln Glu Gly Leu Val Gln Ile Ser Ser His225 230 235 240Pro Pro Thr His Tyr Thr Ile Tyr Pro Lys Arg Asn Arg Phe Asp Asp
245 250 255Leu Thr Asn Pro Thr Asn Pro Pro Leu Lys Glu Ile Lys Gln Glu Thr
260 265 270Lys Glu Arg Glu Pro Thr Pro Thr Lys Glu Thr Leu Thr Pro Thr Thr
275 280 285Pro Lys Pro Ile Met Pro Thr Leu Ala Pro Ile Ile Glu Asn Asp Asn
290 295 300Lys Thr Glu Ash Gln Lys Thr Pro Asn His Pro Lys Lys Glu Glu Asn305 310 315 320Pro Gln Glu Asn Thr Gln Glu Glu Met Ile Glu Gly Arg Ile Glu Glu
325 330 335Met Ile Lys Glu Asn Leu Lys Lys Glu Glu Lys Glu Val Gln Asn Ala
340 345 350Pro Asn Phe Ser Pro Val Thr Pro Thr Ser Ala Lys Lys Pro Val Met
355 360 365Val Lys Glu Leu Ser Glu Asn Lys Glu Ile Leu Asp Gly Leu Asp Tyr
370 375 380Gly Glu Val Gln Lys Pro Lys Asp Tyr Glu Leu Pro Thr Thr Gln Leu385 390 395 400Leu Asn Ala Val Cys Leu Lys Asp Thr Ser Leu Asp Glu Asn Glu Ile
405 410 415Asp Gln Lys Ile GlnAsp Leu Leu Ser Lys Leu Arg Thr Phe Lys Ile
420 425 430Asp Gly Asp Ile Ile Arg Thr Tyr Ser Gly Pro Ile Val Thr Thr Phe
435 440 445Glu Phe Arg Pro Ala Pro Asn Val Lys Val Ser Arg Ile Leu Gly Leu
450 455 460Ser Asp Asp Leu Ala Met Thr Leu Cys Ala Glu Ser Ile Arg Ile Gln465 470 475 480Ala Pro Ile Lys Gly Lys Asp Val Val Gly Ile Glu Ile Pro Asn Ser
485 490 495Gln Ser Gln Ile Ile Tyr Leu Arg Glu Ile Leu Glu Ser Glu Leu Phe
500 505 510Gln Lys Ser Ser Ser Pro Leu Thr Leu Ala Leu Gly Lys Asp Ile Val
515 520 525Gly Asn Pro Phe Ile Thr Asp Leu Lys Lys Leu Pro His Leu Leu Ile
530 535 540Ala Gly Thr Thr Gly Ser Gly Lys Ser Val Gly Val Asn Ala Met Ile545 550 555 560Leu Ser Leu Leu Tyr Lys Asn Pro Pro Asp Gln Leu Lys Leu Val Met
565 570 575Ile Asp Pro Lys Met Val Glu Phe Ser Ile Tyr Ala Asp Ile Pro His
580 585 590Leu Leu Thr Pro Ile Ile Thr Asp Pro Lys Lys Ala Ile Gly Ala Leu
595 600 605Gln Ser Val Ala Lys Glu Met Glu Arg Arg Tyr Ser Leu Met Ser Glu
610 615 620Tyr Lys Val Lys Thr Ile Asp Ser Tyr Asn Glu Gln Ala Pro Ser Asn625 630 635 640Gly Val Glu Ala Phe Pro Tyr Leu Ile Val Val Ile Asp Glu Leu Ala
645 650 655Asp Leu Met Met Thr Gly Gly Lys Glu Ala Glu Phe Pro Ile Ala Arg
660 665 670Ile Ala Gln Met Gly Arg Ala Ser Gly Leu His Leu Ile Val Ala Thr
675 680 685Gln Arg Pro Ser Val Asp Val Val Thr Gly Leu Ile Lys Thr Asn Leu
690 695 700Pro Ser Arg Val Ser Phe Arg Val Gly Thr Lys Ile Asp Ser Lys Val705 710 715 720Ile Leu Asp Thr Asp Gly Ala Gln Ser Leu Leu Gly Arg Gly Asp Met
725 730 735Leu Phe Thr Pro Pro Gly Ala Asn Gly Leu Val Arg Leu His Ala Pro
740 745 750Phe Ala Thr Glu Asp Glu Ile Lys Lys Ile Val Asp Phe Ile Lys Ala
755 760 765Gln Lys Glu Val Gln Tyr Asp Lys Asp Phe Leu Leu Glu Glu Ser Arg
770 775 780Met Pro Leu Asp Thr Pro Asn Tyr Gln Gly Asp Asp Ile Leu Glu Arg785 790 795 800Ala Lys Ala Val Ile Leu Glu Lys Lys Ile Thr Ser Thr Ser Phe Leu
805 810 815Gln Arg Gln Leu Lys Ile Gly Tyr Asn Gln Ala Ala Thr Ile Thr Asp
820 825 830Glu Leu Glu Ala Gln Gly Phe Leu Ser Pro Arg Asn Ala Lys Gly Asn
835 840 845Arg Glu Ile Leu Gln Asn Phe
850855 (2) sequence 985 data: (i) sequence characteristics:length (A): 1136 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1094 (D) other information: (xi) Description of the sequence: sequence 985: AACCATAAAA ACGATACAAT AGCGGTATTT TAATAAAACA AGGAGTTTTA ATG AGA 56
Met Arg
1GTT CAA TCT AAA GGT TTT GCT ATT TTT TCT AAA GAC GGG CAT TTC AAA 104Val Gln Ser Lys Gly Phe Ala Ile Phe Ser Lys Asp Gly His Phe Lys
5 10 15CCC CAT GAT TTT AGC CGC CAT GCT GTA GGC CCT AAA GAT GTG TTG ATT 152Pro His Asp Phe Ser Arg His Ala Val Gly Pro Lys Asp Val Leu Ile
20 25 30GAC ATT CTT TAT GCA GGG ATT TGT CAT AGC GAT ATT CAT AGC GCT TAT 200Asp Ile Leu Tyr Ala Gly Ile Cys His Ser Asp Ile His Ser Ala Tyr35 40 45 50AGC GAA TGG AAA GAA GGC ATT TAC CCT ATG GTT CCT GGG CAT GAA ATT 248Ser Glu Trp Lys Glu Gly Ile Tyr Pro Met Val Pro Gly His Glu Ile
55 60 65GCT GGG GCC ATC AAA GAA GTG GGT AAG GAA GTT AAG AAA TTT AAG GTT 296Ala Gly Ala Ile Lys Glu Val Gly Lys Glu Val Lys Lys Phe Lys Val
70 75 80GGC GAT GTG GTG GGC GTG GGC TGT TTT GTC AAT TCA TGC AAA GCG TGT 344Gly Asp Val Val Gly Val Gly Cys Phe Val Asn Ser Cys Lys Ala Cys
85 90 95AAG CCC TGT AAA GAA CAC CAA GAG CAA TTT TGC GCC AAA GTG GTA TTC 392Lys Pro Cys Lys Glu His Gln Glu Gln Phe Cys Ala Lys Val Val Phe
100 105 110ACT TAC GAT TGTTTG GAT TAT TTC CAT GAC AAC GAA CCC CAC ATG GGC 440Thr Tyr Asp Cys Leu Asp Tyr Phe His Asp Asn Glu Pro His Met Gly115 120 125 130GGA TAC TCT AAT AAT ATT GTA GTG GAT GAA AAC TAT GTG ATT AGC GTG 488Gly Tyr Ser Asn Asn Ile Val Val Asp Glu Asn Tyr Val Ile Ser Val
135 140 145GAT AAA AAC GCT CCT TTA GAA AAA GTA GCC CCC TTG CTT TGT GCG GGC 536Asp Lys Asn Ala Pro Leu Glu Lys Val Ala Pro Leu Leu Cys Ala Gly
150 155 160ATC ACC ACT TAT TCG CCC TTA AAA TTT TCT AAG GTT ACT AAA GGC ACA 584Ile Thr Thr Tyr Ser Pro Leu Lys Phe Ser Lys Val Thr Lys Gly Thr
165 170 175AAA GTT GGC GTC GCT GGG TTT GGC GGG CTA GGA AGC ATG GCG GTT AAA 632Lys Val Gly Val Ala Gly Phe Gly Gly Leu Gly Ser Met Ala Val Lys
180 185 190TAC GCT GTG GCT ATG GGG GCT GAA GTG AGC GTT TTT GCA AGA AAC GAA 680Tyr Ala Val Ala Met Gly Ala Glu Val Ser Val Phe Ala Arg Asn Glu195 200 205 210CAC AAA AAG CAA GAC GCT TTG AGC ATG GGG GTT AAA CAT TTC TAC ACT 728His Lys Lys Gln Asp Ala Leu Ser Met Gly Val Lys His Phe Tyr Thr
215 220 225GAC CCC AAA CAA TGC AAA GAG GAA TTG GAC TTT ATC ATT TCA ACC ATT 776Asp Pro Lys Gln Cys Lys Glu Glu Leu Asp Phe Ile Ile Ser Thr Ile
230 235 240CCT ACC CAT TAT GAT TTA AAA GAC TAC CTC AAG CTC TTA ACT TAT AAT 824Pro Thr His Tyr Asp Leu Lys Asp Tyr Leu Lys Leu Leu Thr Tyr Asn
245 250 255GGC GAT CTA GCC CTT GTG GGA CTC CCC CCT GTA GAA ATC GCT CCA GCG 872Gly Asp LeuAla Leu Val Gly Leu Pro Pro Val Glu Ile Ala Pro Ala
260 265 270CTT AGC GTT TTT GAT TTT ATC CAT TTA GGC AAT CGC AAG GTT TAT GGC 920Leu Ser Val Phe Asp Phe Ile His Leu Gly Asn Arg Lys Val Tyr Gly275 280 285 290TCA TTG ATT GGG GGC ATT AAA GAA ACC CAA GAA ATG ATG GAT TTT TCT 968Ser Leu Ile Gly Gly Ile Lys Glu Thr Gln Glu Met Met Asp Phe Ser
295 300 305ATC AAA CAC AAT ATT TAC CCT GAA ATA GAT TTG ATC TTA GGC AAG GAT 1016Ile Lys His Asn Ile Tyr Pro Glu Ile Asp Leu Ile Leu Gly Lys Asp
310 315 320ATT GAC ACC GCT TAT CAT AAT CTA ACC CAT GGG AAA GCG AAA TTC CGC 1064Ile Asp Thr Ala Tyr His Asn Leu Thr His Gly Lys Ala Lys Phe Arg
325 330 335TAT GTG ATT GAT ATG AAA AAA TCG TTT GAT TAAAAGTTTT GGCTCTAGCT CTT 1117Tyr Val Ile Asp Met Lys Lys Ser Phe Asp
340345 TTTTAAGAGC TTGAGTTGG 1136 (2) sequence 986 data: (i) sequence characteristics: length (A): 348 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 986: met Arg Val Gln Ser Lys Gly Phe Ala Ile Phe Ser Lys Asp Gly His 151015 Phe Lys Pro His Asp Phe Ser Arg His Ala Val Gly Pro Lys Asp Val
20 25 30Leu Ile Asp Ile Leu Tyr Ala Gly Ile Cys His Ser Asp Ile His Ser
35 40 45Ala Tyr Ser Glu Trp Lys Glu Gly Ile Tyr Pro Met Val Pro Gly His
50 55 60Glu Ile Ala Gly Ala Ile Lys Glu Val Gly Lys Glu Val Lys Lys Phe65 70 7580Lys Val Gly Asp Val Val Gly Val Gly Cys Phe Val Asn Ser Cys Lys
85 90 95Ala Cys Lys Pro Cys Lys Glu His Gln Glu Gln Phe Cys Ala Lys Val
100 105 110Val Phe Thr Tyr Asp Cys Leu Asp Tyr Phe His Asp Asn Glu Pro His
115 120 125Met Gly Gly Tyr Ser Asn Asn Ile Val Val Asp Glu Asn Tyr Val Ile
130 135 140Ser Val Asp Lys Asn Ala Pro Leu Glu Lys Val Ala Pro Leu Leu Cys145 150 155 160Ala Gly Ile Thr Thr Tyr Ser Pro Leu Lys Phe Ser Lys Val Thr Lys
165 170 175Gly Thr Lys Val Gly Val Ala Gly Phe Gly Gly Leu Gly Ser Met Ala
180 185 190Val Lys Tyr Ala Val Ala Met Gly Ala Glu Val Ser Val Phe Ala Arg
195 200 205Asn Glu His Lys Lys Gln Asp Ala Leu Ser Met Gly Val Lys His Phe
210 215 220Tyr Thr Asp Pro Lys Gln Cys Lys Glu Glu Leu Asp Phe Ile Ile Ser225 230 235 240Thr Ile Pro Thr His Tyr Asp Leu Lys Asp Tyr Leu Lys Leu Leu Thr
245 250 255Tyr Asn Gly Asp Leu Ala Leu Val Gly Leu Pro Pro Val Glu Ile Ala
260 265 270Pro Ala Leu Ser Val Phe Asp Phe Ile His Leu Gly Asn Arg Lys Val
275 280 285Tyr Gly Ser Leu Ile Gly Gly Ile Lys Glu Thr Gln Glu Met Met Asp
290 295 300Phe Ser Ile Lys His Asn Ile Tyr Pro Glu Ile Asp Leu Ile Leu Gly305 310 315 320Lys Asp Ile Asp Thr Ala Tyr His Asn Leu Thr His Gly Lys Ala Lys
325 330 335Phe Arg Tyr Val Ile Asp Met Lys Lys Ser Phe Asp
340345 (2) sequence 987 data: (i) sequence characteristics: length (A): 1378 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1317 (D) other information: (xi) Description of the sequence: sequence 987: TTAAAAAAGG GTGTTTAATT TTTT ATG ACT TCA GCT TCA AGC CAT TCT TTT 51
Met Thr Ser Ala Ser Ser His Ser Phe
1 5AAA GAA CAA GAT TTT CAT ATT CCT ATC GCTTTT GCT TTT GAT AAG AAT 99Lys Glu Gln Asp Phe His Ile Pro Ile Ala Phe Ala Phe Asp Lys Asn10 15 20 25TAC CTC ATT CCT GCG GGC GCG TGT CTT TAT TCC TTG CTA GAA AGC ATC 147Tyr Leu Ile Pro Ala Gly Ala Cys Leu Tyr Ser Leu Leu Glu Ser Ile
30 35 40GCT AAA GCC AAT AAA AAA ATC CGT TAC ACC CTA CAC GCT TTA GTG GTA 195Ala Lys Ala Asn Lys Lys Ile Arg Tyr Thr Leu His Ala Leu Val Val
45 50 55GGC TTG AAT GAA GAA GAT AAA GCA AAG CTT AAT CAA ATC ACA GAG CCT 243Gly Leu Asn Glu Glu Asp Lys Ala Lys Leu Asn Gln Ile Thr Glu Pro
60 65 70TTT AAA GAA TTT GCC GCT TTG GAA GTG AGA GAT ATT GAG TCT TTT TTA 291Phe Lys Glu Phe Ala Ala Leu Glu Val Arg Asp Ile Glu Ser Phe Leu
7580 85GAC ACT ATC CCT AAC CCT TTT GAT GAG GAT TTC ACT AAG CGT TTT TCT 339Asp Thr Ile Pro Asn Pro Phe Asp Glu Asp Phe Thr Lys Arg Phe Ser90 95 100 105AAA ATG GTG TTA GTG AAG TAT TTT TTG GCG GAT TTG TTC CCC AAA TAT 387Lys Met Val Leu Val Lys Tyr Phe Leu Ala Asp Leu Phe Pro Lys Tyr
110 115 120TCC AAA ATG GTG TGG AGC GAT GTG GAT GTC ATC TTT TGC AAT GAA TTT 435Ser Lys Met Val Trp Ser Asp Val Asp Val Ile Phe Cys Asn Glu Phe
125 130 135AGC GCT GAT TTC TTA AAC CTT GAA GAA AAT GAT GAG AAT TAT TTT TAT 483Ser Ala Asp Phe Leu Asn Leu Glu Glu Asn Asp Glu Asn Tyr Phe Tyr
140 145 150GGA GTT TTA GAA GTT GAA AAG CAC CAC ATG ATG GAA GGG TTT TTG TTT 531Gly Val Leu Glu Val Glu Lys His His Met Met Glu Gly Phe Leu Phe
155 160 165TGC AAT TTA GAT TAC CAG CGC AAG AAA AAT TTC ACC TTA AGA ATG CAT 579Cys Asn Leu Asp Tyr Gln Arg Lys Lys Asn Phe Thr Leu Arg Met His170 175 180 185GAG CTT TTA AGG GGG AAT GAG GCT AAA GGG GAG TTG GAT TTC ACG AAA 627Glu Leu Leu Arg Gly Asn Glu Ala Lys Gly Glu Leu Asp Phe Thr Lys
190 195 200TGG TGT TGG CCT AAC ATG AAA GCT TTA GGG ATT GAA TAT TGC GTT TTC 675Trp Cys Trp Pro Asn Met Lys Ala Leu Gly Ile Glu Tyr Cys Val Phe
205 210 215CCT TAT TAT TAC ACC ATT AAA GAT TTT TCT AAC GCG TAT TTA AAC GAG 723Pro Tyr Tyr Tyr Thr Ile Lys Asp Phe Ser Asn Ala Tyr Leu Asn Glu
220 225 230AAT TAC AAG AAA ACC ATT TTA GAG GCA CGA GAA AAC CCT ACC ATT ATC 771Asn Tyr Lys Lys Thr Ile Leu Glu Ala Arg Glu Asn Pro Thr Ile Ile
235 240 245CAC TAT GAC GCT TGG TGG GGA GCG GTG AAG CCT TGG GAC TAT CCT TTT 819His Tyr Asp Ala Trp Trp Gly Ala Val Lys Pro Trp Asp Tyr Pro Phe250 255 260 265GGT TTA AAA GCG GAT TTA TGG CTG AAC GCT TTG GCT AAA ACC CCT TTT 867Gly Leu Lys Ala Asp Leu Trp Leu Asn Ala Leu Ala Lys Thr Pro Phe
270 275 280ATG AGC GAT TGG ATT GAT TCG ATC GCT AGG GTG GAA ATA GGC AGC GAA 915Met Ser Asp Trp Ile Asp Ser Ile Ala Arg Val Glu Ile Gly Ser Glu
285 290 295AAA TGG CAT CGT TAC CAC AGC ATC GTT GCC TAT CAC TAC TAC TTT CCC 963Lys Trp His Arg Tyr His Ser Ile Val Ala Tyr His Tyr Tyr Phe Pro
300 305 310CTA TGG AAG ACT GAA GAG CAG ATC GCC CAT GAC GCA CTC AAG ACC TTT 1011Leu Trp Lys Thr Glu Glu Gln Ile Ala His Asp Ala Leu Lys Thr Phe
315 320 325TTA GAC CAT TAT TTT TCG TGC ATC CAT GCC GCA ATC AAG CAA GAA AAT 1059Leu Asp His Tyr Phe Ser Cys Ile His Ala Ala Ile Lys Gln Glu Asn330 335 340 345CTC GGA ATG TTC TTG AAC CAC TAC TTC TCG CAT GCC CAT GCA GAG ATC 1107Leu Gly Met Phe Leu Asn His Tyr Phe Ser His Ala His Ala Glu Ile
350 355 360AAA GAA AAC TCC CTT GAA ATG TTC TTG AAC CAC TAC TTC TCG CAT GTT 1155Lys Glu Asn Ser Leu Glu Met Phe Leu Asn His Tyr Phe Ser His Val
365 370 375TAT AGG CTC CCT AAA AAA GCA CGG AAG AGA CTC TTT AGG GTG TTT GTC 1203Tyr Arg Leu Pro Lys Lys Ala Arg Lys Arg Leu Phe Arg Val Phe Val
380 385 390AAA CAC TGC ATC CTC ATA CCA CTC AAG AGC CTT GTG GGT AAG ACT CTA 1251Lys His Cys Ile Leu Ile Pro Leu Lys Ser Leu Val Gly Lys Thr Leu
395 400 405CGA CTC TTA AAA CTC CAT GCG CTA GCT AAA AAA ATC CTA ATC CAA CTC 1299Arg Leu Leu Lys Leu His Ala Leu Ala Lys Lys Ile Leu Ile Gln Leu410 415 420 425AAG CTC TTA AAA AAG AGC TAGAGCCAAA ACTTTTAATC AAACGATTTT TTCATATC 1355Lys Leu Leu Lys Lys Ser
430AATCACATAG CGGAATTTCG CTT 1378 (2) sequence 988 data: (i) sequence characteristics: length (A): 431 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 988: met Thr Ser Ala Ser Ser His Ser Phe Lys Glu Gln Asp Phe His Ile 151015 Pro Ile Ala Phe Ala Phe Asp Lys Asn Tyr Leu Ile Pro Ala Gly Ala
20 25 30Cys Leu Tyr Ser Leu Leu Glu Ser Ile Ala Lys Ala Asn Lys Lys Ile
35 40 45Arg Tyr Thr Leu His Ala Leu Val Val Gly Leu Asn Glu Glu Asp Lys
50 55 60Ala Lys Leu Asn Gln Ile Thr Glu Pro Phe Lys Glu Phe Ala Ala Leu65 70 75 80Glu Val Arg Asp Ile Glu Ser Phe Leu Asp Thr Ile Pro Asn Pro Phe
85 90 95Asp Glu Asp Phe Thr Lys Arg Phe Ser Lys Met Val Leu Val Lys Tyr
100 105 110Phe Leu Ala Asp Leu Phe Pro Lys Tyr Ser Lys Met Val Trp Ser Asp
115 120 125Val Asp Val Ile Phe Cys AsnGlu Phe Ser Ala Asp Phe Leu Asn Leu
130 135 140Glu Glu Asn Asp Glu Asn Tyr Phe Tyr Gly Val Leu Glu Val Glu Lys145 150 155 160His His Met Met Glu Gly Phe Leu Phe Cys Asn Leu Asp Tyr Gln Arg
165 170 175Lys Lys Asn Phe Thr Leu Arg Met His Glu Leu Leu Arg Gly Asn Glu
180 185 190Ala Lys Gly Glu Leu Asp Phe Thr Lys Trp Cys Trp Pro Asn Met Lys
195 200 205Ala Leu Gly Ile Glu Tyr Cys Val Phe Pro Tyr Tyr Tyr Thr Ile Lys
210 215 220Asp Phe Ser Asn Ala Tyr Leu Asn Glu Asn Tyr Lys Lys Thr Ile Leu225 230 235 240Glu Ala Arg Glu Asn Pro Thr Ile Ile His Tyr Asp Ala Trp Trp Gly
245 250 255Ala Val Lys Pro Trp Asp Tyr Pro Phe Gly Leu Lys Ala Asp Leu Trp
260 265 270Leu Asn Ala Leu Ala Lys Thr Pro Phe Met Ser Asp Trp Ile Asp Ser
275 280 285Ile Ala Arg Val Glu Ile Gly Ser Glu Lys Trp His Arg Tyr His Ser
290 295 300Ile Val Ala Tyr His Tyr Tyr Phe Pro Leu Trp Lys Thr Glu Glu Gln305 310 315 320Ile Ala His Asp Ala Leu Lys Thr Phe Leu Asp His Tyr Phe Ser Cys
325 330 335Ile His Ala Ala Ile Lys Gln Glu Asn Leu Gly Met Phe Leu Asn His
340 345 350Tyr Phe Ser His Ala His Ala Glu Ile Lys Glu Asn Ser Leu Glu Met
355 360 365Phe Leu Asn His Tyr Phe Ser His Val Tyr Arg Leu Pro Lys Lys Ala
370 375 380Arg Lys Arg Leu Phe Arg Val Phe Val Lys His Cys Ile Leu Ile Pro385 390 395 400Leu Lys Ser Leu Val Gly Lys Thr Leu Arg Leu Leu Lys Leu His Ala
405 410 415Leu Ala Lys Lys Ile Leu Ile Gln Leu Lys Leu Leu Lys Lys Ser
420425430 (2) data of sequence 989: (i) sequence characteristics: length (A): 650 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 603 (D) other information: (xi) Description of the sequence: sequence 989: GCTGAATTCA ATTTATTTTA TACGATATTA AGGAGACATA TTACC ATG TTT CAA ATT 57
Met Phe Gln Ile
1AGA TGG CAT GCA CGA GCG GGT CAA GGT GCA ATC ACT GGC GCT AAA GGG 105Arg Trp His Ala Arg Ala Gly Gln Gly Ala Ile Thr Gly Ala Lys Gly5 10 15 20TTG GCT GAT GTG ATT TCA AAA ACA GGC AAA GAA GTG CAA GCG TTC GCT 153Leu Ala Asp Val Ile Ser Lys Thr Gly Lys Glu Val Gln Ala Phe Ala
25 30 35TCT TAT GGT TCA GCT AAA AGG GGG GCT GCT ATG ATG GCT TAT AAC CGC 201Ser Tyr Gly Ser Ala Lys Arg Gly Ala Ala Met Met Ala Tyr Asn Arg
40 45 50GTT GAT GAT GAA CCT ATC TTA AAC CAT GAA CGC TTC ATG CAG CCT GAT 249Val Asp Asp Glu Pro Ile Leu Asn His Glu Arg Phe Met Gln Pro Asp
55 60 65TAT GTG CTG GTG ATT GAC CCT GGT TTG GTT TTC ATT GAA AAC ATC TTC 297Tyr Val Leu Val Ile Asp Pro Gly Leu Val Phe Ile Glu Asn Ile Phe
70 75 80GCC AAT GAA AAA GAA GAC ACG ACT TAT ATT ATC ACT AGC TAC CTT AAC 345Ala Asn Glu Lys Glu Asp Thr Thr Tyr Ile Ile Thr Ser Tyr Leu Asn85 90 95 100AAA GAA GAA TTG TTT GAA AAA AAA CCT GAA TTA AAA ACC CGT AAG GTG 393Lys Glu Glu Leu Phe Glu Lys Lys Pro Glu Leu Lys Thr Arg Lys Val
105 110 115TTT TTA GTG GAT TGT TTA AAA ATC TCT ATG GAA ACC TTA AAA CGC CCC 441Phe Leu Val Asp Cys Leu Lys Ile Ser Met Glu Thr Leu Lys Arg Pro
120 125 130ATC CCT AAC ACG CCC ATG TTA GGG GCG TTA ATG AAA GTG TCT GGC ATG 489Ile Pro Asn Thr Pro Met Leu Gly Ala Leu Met Lys Val Ser Gly Met
135 140 145CTT GAA ATT GGG GCT TTT AAA GAA GCT TTT AAG AAA GTT TTA GGC AAA 537Leu Glu Ile Gly Ala Phe Lys Glu Ala Phe Lys Lys Val Leu Gly Lys
150 155 160AAA CTC ACG CAA GAA GTC ATT GAC GCT AAC ATG CTC GCT ATC CAA AGA 585Lys Leu Thr Gln Glu Val Ile Asp Ala Asn Met Leu Ala Ile Gln Arg165 170 175 180GCT TAT GAA GAA GTT CAA TAACATTAAG GAACAAAGAT GAAAGATTGG AACGAATT 641Ala Tyr Glu Glu Val Gln
185TGAAATGGG 650 (2) sequence 990 data: (i) sequence characteristics: length (A): 186 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 990: met Phe Gln Ile Arg Trp His Ala Arg Ala Gly Gln Gly Ala Ile Thr 151015 Gly Ala Lys Gly Leu Ala Asp Val Ile Ser LysThr Gly Lys Glu Val
20 25 30Gln Ala Phe Ala Ser Tyr Gly Ser Ala Lys Arg Gly Ala Ala Met Met
35 40 45Ala Tyr Asn Arg Val Asp Asp Glu Pro Ile Leu Asn His Glu Arg Phe
50 55 60Met Gln Pro Asp Tyr Val Leu Val Ile Asp Pro Gly Leu Val Phe Ile65 70 75 80Glu Asn Ile Phe Ala Asn Glu Lys Glu Asp Thr Thr Tyr Ile Ile Thr
85 90 95Ser Tyr Leu Asn Lys Glu Glu Leu Phe Glu Lys Lys Pro Glu Leu Lys
100 105 110Thr Arg Lys Val Phe Leu Val Asp Cys Leu Lys Ile Ser Met Glu Thr
115 120 125Leu Lys Arg Pro Ile Pro Asn Thr Pro Met Leu Gly Ala Leu Met Lys
130 135 140Val Ser Gly Met Leu Glu Ile Gly Ala Phe Lys Glu Ala Phe Lys Lys145 150 155 160Val Leu Gly Lys Lys Leu Thr Gln Glu Val Ile Asp Ala Asn Met Leu
165 170 175Ala Ile Gln Arg Ala Tyr Glu Glu Val Gln
180185 (2) sequence 991 data: (i) sequence characteristics: length (A): 1008 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 954 (D) other information: (xi) Description of the sequence: sequence 991: TTGGGGATTT TAACTTTT ATG GAT TTT TGC TCT GGC ATT GGT GGA GGC CGT 51
Met Asp Phe Cys Ser Gly Ile Gly Gly Gly Arg
1 5 10TTG GGC TTG GAG CAA TGC CAT TTA AAA TGC GTA GGG CAT GCA GAA ATC 99Leu Gly Leu Glu Gln Cys His Leu Lys Cys Val Gly His Ala Glu Ile
15 20 25AAT CAT GAA GCC CTT AGG ACT TAT GAA TTA TTT TTT AAA GAT ACC CAT 147Asn His Glu Ala Leu Arg Thr Tyr Glu Leu Phe Phe Lys Asp Thr His
30 35 40AAT TTT GGG GAT TTG ATG CGA ATC AAC CCT AAT GAT TTA CCC GAT TTT 195Asn Phe Gly Asp Leu Met Arg Ile Asn Pro Asn Asp Leu Pro Asp Phe
45 50 55GAT GCA CTC ATT AGC GGG TTT CCT TGT CAA GCT TTT TCT ATC AAT GGC 243Asp Ala Leu Ile Ser Gly Phe Pro Cys Gln Ala Phe Ser Ile Asn Gly60 65 70 75AAA AGG AAG GGG CTT GAA GAT GAA AGA GGG ACG ATT ATT TAC GGG CTT 291Lys Arg Lys Gly Leu Glu Asp Glu Arg Gly Thr Ile Ile Tyr Gly Leu
80 85 90ATT CGC ATT TTA AAA GTT AAA CAG CCT GAA TGT TTC TTG CTT GAA AAT 339Ile Arg Ile Leu Lys Val Lys Gln Pro Glu Cys Phe Leu Leu Glu Asn
95 100 105GTT AAG GGC TTG ATC AAT CAT AAT AAA AAG GCA ACT TTT AAT ATT ATT 387Val Lys Gly Leu Ile Asn His Asn Lys Lys Ala Thr Phe Asn Ile Ile
110 115 120ATC AAA GCC CTA CAA GAA GTG GGT TAT ACA ACT TAT TAT AAA ATT TTA 435Ile Lys Ala Leu Gln Glu Val Gly Tyr Thr Thr Tyr Tyr Lys Ile Leu
125 130 135AAC AGC GCT GAT TTT CAA TTA GCC CAA AAT AGA GAA CGC CTT TAT ATC 483Asn Ser Ala Asp Phe Gln Leu Ala Gln Asn Arg Glu Arg Leu Tyr Ile140 145 150 155GTA GGG TTT AGG AAG GAT TTA AAA CAC CCA TTT AAT TTC CCT TTA GGT 531Val Gly Phe Arg Lys Asp Leu Lys His Pro Phe Asn Phe Pro Leu Gly
160 165 170TTA GCC AAT GAT TAT TAT TTC AAG GAT TTT TTA GAC GCT GAT AAT GAA 579Leu Ala Asn Asp Tyr Tyr Phe Lys Asp Phe Leu Asp Ala Asp Asn Glu
175 180 185TGT TAT TTG GAT GTG AGT AAC GCT GCA TTT CAA AGA TAC TTG CAC AAC 627Cys Tyr Leu Asp Val Ser Asn Ala Ala Phe Gln Arg Tyr Leu His Asn
190 195 200CGA TAC AAC CAT AAC CGG GTT TCT TTA GAG GAT CTC TTA ACT TTA GAA 675Arg Tyr Asn His Asn Arg Val Ser Leu Glu Asp Leu Leu Thr Leu Glu
205 210 215AAC GCT GTT TTA GAC ACA AGA CAA TCT GAT TTA AGG TTG TAT TCT AAT 723Asn Ala Val Leu Asp Thr Arg Gln Ser Asp Leu Arg Leu Tyr Ser Asn220 225 230 235GTT TTT CCT ACT TTA AGG ACT TCT CGG CAT GGC CTG TTT TAT ACC CAA 771Val Phe Pro Thr Leu Arg Thr Ser Arg His Gly Leu Phe Tyr Thr Gln
240 245 250AAA GGC AAA ATC AAA AGA TTA AAC GCT ATT GAA AGC TTG CTT TTG CAA 819Lys Gly Lys Ile Lys Arg Leu Asn Ala Ile Glu Ser Leu Leu Leu Gln
255 260 265GGA TTT CCT AGG GAT TTG ATC GCT AAG ATT AAA GAT AAT CCT AAC TTT 867Gly Phe Pro Arg Asp Leu Ile Ala Lys Ile Lys Asp Asn Pro Asn Phe
270 275 280AAA GCA AGC CAT TTG CTA TCC CAA GCG GGG AAT GCG ATG AGC GTG AAT 915Lys Ala Ser His Leu Leu Ser Gln Ala Gly Asn Ala Met Ser Val Asn
285290295 GTG ATT GCT GCA ATC GCT AAA CAA ATG TTA AAG GCG ATT TAATAAGGGA GC 966Val Ile Ala Ala Ile Ala Lys Gln Met Leu Lys Ala Ile 300305310 TTTAAGGGGA GAATGATTTC AAAATACCCC CTATCCCCTT AA 1008 (2) sequence 992 data: (i) sequence characteristics: length (A): 312 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 992: met Asp Phe Cys Ser Gly Ile Gly Gly Gly Arg Leu Gly Leu Glu Gln 151015 Cys His Leu Lys Cys Val Gly His Ala Glu Ile Asn His Glu Ala Leu
20 25 30Arg Thr Tyr Glu Leu Phe Phe Lys Asp Thr His Asn Phe Gly Asp Leu
35 40 45Met Arg Ile Asn Pro Asn Asp Leu Pro Asp Phe Asp Ala Leu Ile Ser
50 55 60Gly Phe Pro Cys Gln Ala Phe Ser Ile Asn Gly Lys Arg Lys Gly Leu65 70 75 80Glu Asp Glu Arg Gly Thr Ile Ile Tyr Gly Leu Ile Arg Ile Leu Lys
85 90 95Val Lys Gln Pro Glu Cys Phe Leu Leu Glu Asn Val Lys Gly Leu Ile
100 105 110Asn His Asn Lys Lys Ala Thr Phe Asn Ile Ile Ile Lys Ala Leu Gln
115 120 125Glu Val Gly Tyr Thr Thr Tyr Tyr Lys Ile Leu Asn Ser Ala Asp Phe
130 135 140Gln Leu Ala Gln Asn Arg Glu Arg Leu Tyr Ile Val Gly Phe Arg Lys145 150 155 160Asp Leu Lys His Pro Phe Asn Phe Pro Leu Gly Leu Ala Asn Asp Tyr
165 170 175Tyr Phe Lys Asp Phe Leu Asp Ala Asp Asn Glu Cys Tyr Leu Asp Val
180 185 190Ser Asn Ala Ala Phe Gln Arg Tyr Leu His Asn Arg Tyr Asn His Asn
195 200 205Arg Val Ser Leu Glu Asp Leu Leu Thr Leu Glu Asn Ala Val Leu Asp
210 215 220Thr Arg Gln Ser Asp Leu Arg Leu Tyr Ser Asn Val Phe Pro Thr Leu225 230 235 240Arg Thr Ser Arg His Gly Leu Phe Tyr Thr Gln Lys Gly Lys Ile Lys
245 250 255Arg Leu Asn Ala Ile Glu Ser Leu Leu Leu Gln Gly Phe Pro Arg Asp
260 265 270Leu Ile Ala Lys Ile Lys Asp Asn Pro Asn Phe Lys Ala Ser His Leu
275 280 285Leu Ser Gln Ala Gly Asn Ala Met Ser Val Asn Val Ile Ala Ala Ile
290295300 Ala Lys Gln Met Leu Lys Ala Ile 305310 (2) sequence 993 data: (i) sequence characteristics: length (A): 1468 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1436 (D) other information: (xi) Description of the sequence: sequence 993: AAAATAAAAA TTATATTAAT CAAGGAGCG ATG AAA GCG ATG GAA GGT AAA ATC 53
Met Lys Ala Met Glu Gly Lys Ile
1 5ATT CAG GTT TTA GGC CCT GTG GTA GAT GTG GAG TTT GAA TCC TAT CTG 101Ile Gln Val Leu Gly Pro Val Val Asp Val Glu Phe Glu Ser Tyr Leu
10 15 20CCG GCG ATT TTT GAA GCG TTA GAC ATT AAT TTT GAA GTC AAT GGT GTT 149Pro Ala Ile Phe Glu Ala Leu Asp Ile Asn Phe Glu Val Asn Gly Val25 30 35 40CAA AAG TCT TTA GTT TTA GAG GTG GCA GCC CAT TTG GGC GGT AAT CGG 197Gln Lys Ser Leu Val Leu Glu Val Ala Ala His Leu Gly Gly Asn Arg
45 50 55GTG CGA GCG ATT GCT ATG GAT ATG ACA GAA GGC TTA GTG CGT AAC CAA 245Val Arg Ala Ile Ala Met Asp Met Thr Glu Gly Leu Val Arg Asn Gln
60 65 70GTG ATC AAG GCT CGC GGC AAA ATG ATT GAA GTG CCT GTG GGC GAA GAA 293Val Ile Lys Ala Arg Gly Lys Met Ile Glu Val Pro Val Gly Glu Glu
75 80 85GTA TTA GGG CGT ATT TTT AAT GTT GTG GGC GAG AGC ATT GAC AAT TTA 341Val Leu Gly Arg Ile Phe Asn Val Val Gly Glu Ser Ile Asp Asn Leu
90 95 100GAG CCG CTT AAG CCG TCC TTA ACT TGG CCC ATT CAC AGA AAA GCC CCT 389Glu Pro Leu Lys Pro Ser Leu Thr Trp Pro Ile His Arg Lys Ala Pro105 110 115 120AGT TTT GAG CAG CAA AGC ACT AAA ACA GAA ATG TTT GAA ACT GGT ATT 437Ser Phe Glu Gln Gln Ser Thr Lys Thr Glu Met Phe Glu Thr Gly Ile
125 130 135AAA GTC ATT GAC TTA CTC GCG CCT TAT TCT AAG GGC GGT AAA GTA GGC 485Lys Val Ile Asp Leu Leu Ala Pro Tyr Ser Lys Gly Gly Lys Val Gly
140 145 150TTG TTT GGT GGG GCT GGC GTA GGC AAA ACG GTG ATC ATT ATG GAG CTT 533Leu Phe Gly Gly Ala Gly Val Gly Lys Thr Val Ile Ile Met Glu Leu
155 160 165ATC CAT AAT GTG GCT TAT AAG CAT AAC GGG TAT TCG GTG TTT GCA GGT 581Ile His Asn Val Ala Tyr Lys His Asn Gly Tyr Ser Val Phe Ala Gly
170 175 180GTG GGG GAG CGC ACC AGA GAG GGG AAT GAT CTG TAT TTT GAA ATG AAA 629Val Gly Glu Arg Thr Arg Glu Gly Asn Asp Leu Tyr Phe Glu Met Lys185 190195 200GAA GGG GGC GTT TTA GAC AAA GTC GCA CTG TGT TAT GGG CAA ATG AAT 677Glu Gly Gly Val Leu Asp Lys Val Ala Leu Cys Tyr Gly Gln Met Asn
205 210 215GAG CCA CCA GGC GCG AGG AAC CGC ATC GCA TTC ACC GGC TTG ACG ATG 725Glu Pro Pro Gly Ala Arg Asn Arg Ile Ala Phe Thr Gly Leu Thr Met
220 225 230GCG GAG TAT TTT CGT GAT GAA AAG GGC TTA GAT GTG TTG ATG TTT ATT 773Ala Glu Tyr Phe Arg Asp Glu Lys Gly Leu Asp Val Leu Met Phe Ile
235 240 245GAC AAC ATC TTT AGA TAC GCT CAA AGC GGT GCG GAA ATG AGC GCG CTA 821Asp Asn Ile Phe Arg Tyr Ala Gln Ser Gly Ala Glu Met Ser Ala Leu
250 255 260TTA GGC CGT ATC CCT TCA GCG GTG GGG TAT CAG CCC ACG CTA GCC GGG 869Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala Gly265 270 275 280
GAA ATG GGG AAA CTT CAA GAG CGT ATC GCT TCC ACT AAA AAT GGC TCT 917Glu Met Gly Lys Leu Gln Glu Arg Ile Ala Ser Thr Lys Asn Gly Ser
285 290 295ATC ACT TCC GTT CAA GCG GTG TAT GTG CCA GCA GAT GAC TTG ACT GAC 965Ile Thr Ser Val Gln Ala Val Tyr Val Pro Ala Asp Asp Leu Thr Asp
300 305 310CCA GCC CCT GCT TCG GTG TTT GCG CAT TTG GAT GCG ACT ACG GTG TTG 1013Pro Ala Pro Ala Ser Val Phe Ala His Leu Asp Ala Thr Thr Val Leu
315 320 325AAT AGA AAG ATC GCT GAA AAA GGG ATT TAT CCG GCG GTG GAT CCT TTG 1061Asn Arg Lys Ile Ala Glu Lys Gly Ile Tyr Pro Ala Val Asp Pro Leu
330 335340GAT TCC ACT TCA AGG ATT TTA AGC CCT CAA ATG ATC GGT GAG AAA CAC 1109Asp Ser Thr Ser Arg Ile Leu Ser Pro Gln Met Ile Gly Glu Lys His345 350 355 360TAT GAA GTC GCT ACC GGT ATC CAG CAG GTT TTA CAA AAA TAC AAG GAT 1157Tyr Glu Val Ala Thr Gly Ile Gln Gln Val Leu Gln Lys Tyr Lys Asp
365 370 375TTG CAA GAC ATT ATT GCG ATT TTG GGA TTA GAC GAA TTG AGC GAA GAG 1205Leu Gln Asp Ile Ile Ala Ile Leu Gly Leu Asp Glu Leu Ser Glu Glu
380 385 390GAT AAA AAA ACG GTT GAA AGG GCC AGA AAA ATT GAG AAG TTT TTA TCC 1253Asp Lys Lys Thr Val Glu Arg Ala Arg Lys Ile Glu Lys Phe Leu Ser
395 400 405CAG CCG TTC TTT GTG GCT GAA GTG TTT ACA GGA AGT CCT GGT AAA TAT 1301Gln Pro Phe Phe Val Ala Glu Val Phe Thr Gly Ser Pro Gly Lys Tyr
410 415 420GTA ACC CTT CAA GAG ACT TTA GAG GGC TTT GGA GGG ATT TTA GAG GGC 1349Val Thr Leu Gln Glu Thr Leu Glu Gly Phe Gly Gly Ile Leu Glu Gly425 430 435 440AAA TAC GAT CAT ATT CCC GAG AAC GCG TTT TAT ATG GTG GGT AGC ATT 1397Lys Tyr Asp His Ile Pro Glu Asn Ala Phe Tyr Met Val Gly Ser Ile
445 450 455CAA GAG GTT TTA GAA AAA GCT AAA AAC ATG AAA AAT TCC TAAGGGTTTT GT 1448Gln Glu Val Leu Glu Lys Ala Lys Asn Met Lys Asn Ser
460 465GATGGCTTTG TTGAAAATTA 1468
(2) Sequence 994 data: (i) sequence characteristics: length (A): 469 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 994: met Lys Ala Met Glu Gly Lys Ile Ile Gln Val Leu Gly Pro Val Val 151015 Asp Val Glu Phe Glu Ser Tyr Leu Pro Ala Ile Phe Glu Ala Leu Asp
20 25 30Ile Asn Phe Glu Val Asn Gly Val Gln Lys Ser Leu Val Leu Glu Val
35 40 45Ala Ala His Leu Gly Gly Asn Arg Val Arg Ala Ile Ala Met Asp Met
50 55 60Thr Glu Gly Leu Val Arg Asn Gln Val Ile Lys Ala Arg Gly Lys Met65 70 75 80Ile Glu Val Pro Val Gly Glu Glu Val Leu Gly Arg Ile Phe Asn Val
85 90 95Val Gly Glu Ser Ile Asp Asn Leu Glu Pro Leu Lys Pro Ser Leu Thr
100 105 110Trp Pro Ile His Arg Lys Ala Pro Ser Phe Glu Gln Gln Ser Thr Lys
115 120 125Thr Glu Met Phe Glu Thr Gly Ile Lys Val Ile Asp Leu Leu Ala Pro
130 135 140Tyr Ser Lys Gly Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly145 150 155 160Lys Thr Val Ile Ile Met Glu Leu Ile His Asn Val Ala Tyr Lys His
165 170 175Asn Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly
180 185 190Asn Asp Leu Tyr Phe Glu Met Lys Glu Gly Gly Val Leu Asp Lys Val
195 200 205Ala Leu Cys Tyr Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Asn Arg
210 215 220Ile Ala Phe Thr Gly Leu Thr Met Ala Glu Tyr Phe Arg Asp Glu Lys225 230 235 240Gly Leu Asp Val Leu Met Phe Ile Asp Asn Ile Phe Arg Tyr Ala Gln
245 250 255Ser Gly Ala Glu Met Ser Ala Leu Leu Gly Arg Ile Pro Ser Ala Val
260 265 270Gly Tyr Gln Pro Thr Leu Ala Gly Glu Met Gly Lys Leu Gln Glu Arg
275 280 285Ile Ala Ser Thr Lys Asn Gly Ser Ile Thr Ser Val Gln Ala Val Tyr
290 295 300Val Pro Ala Asp Asp Leu Thr Asp Pro Ala Pro Ala Ser Val Phe Ala305 310 315 320His Leu Asp Ala Thr Thr Val Leu Asn Arg Lys Ile Ala Glu Lys Gly
325 330 335Ile Tyr Pro Ala Val Asp Pro Leu Asp Ser Thr Ser Arg Ile Leu Ser
340 345 350Pro Gln Met Ile Gly Glu Lys His Tyr Glu Val Ala Thr Gly Ile Gln
355 360 365Gln Val Leu Gln Lys Tyr Lys Asp Leu Gln Asp Ile Ile Ala Ile Leu
370 375 380Gly Leu Asp Glu Leu Ser Glu Glu Asp Lys Lys Thr Val Glu Arg Ala385 390 395 400Arg Lys Ile Glu Lys Phe Leu Ser Gln Pro Phe Phe Val Ala Glu Val
405 410 415Phe Thr Gly Ser Pro Gly Lys Tyr Val Thr Leu Gln Glu Thr Leu Glu
420 425 430Gly Phe Gly Gly Ile Leu Glu Gly Lys Tyr Asp His Ile Pro Glu Asn
435 440 445Ala Phe Tyr Met Val Gly Ser Ile Gln Glu Val Leu Glu Lys AlaLys
450455460 Asn Met Lys Asn Ser465 (2) sequence 995 data: (i) sequence characteristics: length (A): 2716bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 2649 (D) other information: (xi) Description of the sequence: sequence 995: TAAGGAACGC TCTATTTTAG GATAATA ATG ATA ATG AAA CAA GAA CCC ACC ACC 54
Met Ile Met Lys Gln Glu Pro Thr Thr
1 5TAC CAA CCA GAA GAG ATA GAA AAA AAG ATT TAT GAA ATT TGC TCT CAT 102Tyr Gln Pro Glu Glu Ile Glu Lys Lys Ile Tyr Glu Ile Cys Ser His10 15 20 25AGG GGG TAT TTT GAA ATT GAT GGC AAT GAA GCG ATC CAA GAA AAA AAC 150Arg Gly Tyr Phe Glu Ile Asp Gly Asn Glu Ala Ile Gln Glu Lys Asn
30 35 40AAA CGA TTT TGC TTG ATG ATG CCC CCT CCT AAT GTG ACC GGT GTG TTG 198Lys Arg Phe Cys Leu Met Met Pro Pro Pro Asn Val Thr Gly Val Leu
45 50 55CAC ATA GGG CAT GCC CTG ACT TTA AGC TTG CAA GAT ATT TTA GCG CGT 246His Ile Gly His Ala Leu Thr Leu Ser Leu Gln Asp Ile Leu Ala Arg
60 65 70TAC AAA CGC ATG GAT GGG TAT AAG ACT TTG TAT CAG CCC GGG TTG GAT 294Tyr Lys Arg Met Asp Gly Tyr Lys Thr Leu Tyr Gln Pro Gly Leu Asp
75 80 85CAC GCT GGC ATT GCA ACG CAA AAT GTC GTG GAA AAG CAG CTT TTA AGT 342His Ala Gly Ile Ala Thr Gln Asn Val Val Glu Lys Gln Leu Leu Ser90 95 100 105CAA GGG ATT AAA AAA GAA GAT TTA GGG CGT GAA GAG TTC ATT AAA AAA 390Gln Gly Ile Lys Lys Glu Asp Leu Gly Arg Glu Glu Phe Ile Lys Lys
110 115 120GTG TGG GAA TGG AAA GAA AAG AGC GGG GGA GCG ATT TTA GAG CAA ATG 438Val Trp Glu Trp Lys Glu Lys Ser Gly Gly Ala Ile Leu Glu Gln Met
125 130 135AAG CGT TTA GGC GTG AGC GCG GCC TTT TCT AGG ACT CGT TTC ACG ATG 486Lys Arg Leu Gly Val Ser Ala Ala Phe Ser Arg Thr Arg Phe Thr Met
140 145 150GAT AAG GGC TTG CAA AGA GCG GTC AAA TTG GCG TTT TTG AAA TGG TAT 534Asp Lys Gly Leu Gln Arg Ala Val Lys Leu Ala Phe Leu Lys Trp Tyr
155 160 165GAA AAA GGT CTC ATT ATT CAA GAT AAT TAC ATG GTG AAT TGG TGC ACT 582Glu Lys Gly Leu Ile Ile Gln Asp Asn Tyr Met Val Asn Trp Cys Thr170 175 180 185AAA GAT GGG GCG TTG AGC GAT ATT GAA GTG GAG TAT GAA GAG CGT AAG 630Lys Asp Gly Ala Leu Ser Asp Ile Glu Val Glu Tyr Glu Glu Arg Lys
190 195 200GGG GCG TTG TAT TAT ATT AGA TAT TAT TTA GAA AAT CAA AAA GAT TAT 678Gly Ala Leu Tyr Tyr Ile Arg Tyr Tyr Leu Glu Asn Gln Lys Asp Tyr
205 210 215TTA GTG GTG GCT ACC ACA CGC CCT GAA ACC TTG TTT GGC GAT AGC GCG 726Leu Val Val Ala Thr Thr Arg Pro Glu Thr Leu Phe Gly Asp Ser Ala
220 225 230CTT ATG GTC AAT CCT AAC GAT GAG AGA TAC AAG CAT TTG GTG GGG CAA 774Leu Met Val Asn Pro Asn Asp Glu Arg Tyr Lys His Leu Val Gly Gln
235 240 245AAA GCG ATC TTG CCT TTA ATC CAT CGC ACA ATC CCT ATT ATC GCT GAT 822Lys Ala Ile Leu Pro Leu Ile His Arg Thr Ile Pro Ile Ile Ala Asp250 255260 265GAA CAT GTT GAA ATG GAG TTT GGC ACA GGG TGT GTG AAA GTA ACC CCT 870Glu His Val Glu Met Glu Phe Gly Thr Gly Cys Val Lys Val Thr Pro
270 275 280GGG CAT GAT TTT AAC GAT TAT GAA GTG GGC AAA CGC CAC CAT TTG GAA 918Gly His Asp Phe Asn Asp Tyr Glu Val Gly Lys Arg His His Leu Glu
285 290 295ACG ATT AAA ATC TTT GAT GAA AAG GGG ATT TTA AAC GCG CAT TGC GGG 966Thr Ile Lys Ile Phe Asp Glu Lys Gly Ile Leu Asn Ala His Cys Gly
300 305 310GAG TTT GAA AAT TTA GAA CGA TTA GAA GCT AGA GAT AAG GTC GTA GAA 1014Glu Phe Glu Asn Leu Glu Arg Leu Glu Ala Arg Asp Lys Val Val Glu
315 320 325AGA TTA AAA GAA AAC GCC CTA TTG GAA AAA ATA GAA GAA CAC ACG CAT 1062Arg Leu Lys Glu Asn Ala Leu Leu Glu Lys Ile Glu Glu His Thr His330 335 340 345CAA GTG GGG CAT TGC TAT CGT TGT CAT AAT GTG GTA GAA CCT TAT GTG 1110Gln Val Gly His Cys Tyr Arg Cys His Asn Val Val Glu Pro Tyr Val
350 355 360TCT AAG CAA TGG TTT GTC AAG CCT GAA ATC GCT CAA AGT TCT ATT GAA 1158Ser Lys Gln Trp Phe Val Lys Pro Glu Ile Ala Gln Ser Ser Ile Glu
365 370 375AAA ATC CAA CAA GGT TTG GCG CGA TTC TAC CCT TCT AAT TGG ATC AAT 1206Lys Ile Gln Gln Gly Leu Ala Arg Phe Tyr Pro Ser Asn Trp Ile Asn
380 385 390AAT TAC AAC GCT TGG ATG AGG GAA TTA CGC CCT TGG TGT ATC AGC AGG 1254Asn Tyr Asn Ala Trp Met Arg Glu Leu Arg Pro Trp Cys Ile Ser Arg
395 400 405CAA TTG TTT TGG GGG CAT CAA ATA CCG GTA TTC ACT TGC GAG AAT AAC 1302Gln Leu Phe Trp Gly His Gln Ile Pro Val Phe Thr Cys Glu Asn Asn410 415 420 425CAC CAG TTC GTA AGC TTA GAC ACC CCC TTA AGT TGC CCT ACT TGT AAG 1350His Gln Phe Val Ser Leu Asp Thr Pro Leu Ser Cys Pro Thr Cys Lys
430 435 440AGC GAA ACA CTA GAG CAA GAT AAG GAT GTG CTA GAC ACA TGG TTT AGT 1398Ser Glu Thr Leu Glu Gln Asp Lys Asp Val Leu Asp Thr Trp Phe Ser
445 450 455TCA GGG CTA TGG GCG TTT TCC ACT CTA GGG TGG GGG CAA GAA AAA AGC 1446Ser Gly Leu Trp Ala Phe Ser Thr Leu Gly Trp Gly Gln Glu Lys Ser
460 465 470GGT TTG TTT AAT GAA AGC GAT TTG AAA GAT TTC TAC CCT AAC ACA ACG 1494Gly Leu Phe Asn Glu Ser Asp Leu Lys Asp Phe Tyr Pro Asn Thr Thr
475 480 485CTC ATT ACT GGG TTT GAC ATC CTC TTT TTT TGG GTG GCT AGG ATG CTT 1542Leu Ile Thr Gly Phe Asp Ile Leu Phe Phe Trp Val Ala Arg Met Leu490 495 500 505TTT TGC AGC GAA TCG CTT TTA GGC GAA TTG CCC TTT AAA GAT ATT TAC 1590Phe Cys Ser Glu Ser Leu Leu Gly Glu Leu Pro Phe Lys Asp Ile Tyr
510 515 520TTG CAC GCC TTA GTG AGA GAT GAA AAG GGT GAA AAA ATG AGC AAA TCT 1638Leu His Ala Leu ValArg Asp Glu Lys Gly Glu Lys Met Ser Lys Ser
525 530 535AAG GGT AAT GTG ATC GAT CCT TTA GAG ATG ATA GAA AAA TAC GGC GCG 1686Lys Gly Asn Val Ile Asp Pro Leu Glu Met Ile Glu Lys Tyr Gly Ala
540 545 550GAT AGC TTG CGT TTC ACT TTA GCC AAT TTG TGC GCT ACG GGT AGG GAC 1734Asp Ser Leu Arg Phe Thr Leu AlaAsn Leu Cys Ala Thr Gly Arg Asp
555 560 565ATT AAG CTT TCC ACT ACG CAT TTA GAA AAT AAC AAG AAT TTC GCC AAC 1782Ile Lys Leu Ser Thr Thr His Leu Glu Asn Asn Lys Asn Phe Ala Asn570 575 580 585AAG CTT TTT AAT GCG GCG AGT TAC TTG AAG CTC AAA CAA GAA TCT TTC 1830Lys Leu Phe Asn Ala Ala Ser Tyr Leu Lys Leu Lys Gln Glu Ser Phe
590 595 600AAA GAT AAA GAG CGT TTG AAT GAA TAC CAA ACG CCT TTG GGG CGT TAT 1878Lys Asp Lys Glu Arg Leu Asn Glu Tyr Gln Thr Pro Leu Gly Arg Tyr
605 610 615GCG AAA TCG CGC TTG AAT TCA GCG ACT AAA GAG GCG CGT AAC GCT TTA 1926Ala Lys Ser Arg Leu Asn Ser Ala Thr Lys Glu Ala Arg Asn Ala Leu
620 625 630GAT AAT TAT CGT TTT AAT GAC GCC ACG ACT TTG TTA TAC CGC TTT TTG 1974Asp Asn Tyr Arg Phe Asn Asp Ala Thr Thr Leu Leu Tyr Arg Phe Leu
635 640 645TGG GGG GAA TTT TGC GAC TGG TTC ATT GAA TTT TCT AAA GTG GAA AAT 2022Trp Gly Glu Phe Cys Asp Trp Phe Ile Glu Phe Ser Lys Val Glu Asn650 655 660 665GAA GCG ATA GAC GAA TTA GGG AGC GTG TTA AAA GAG GCT TTA AAA CTC 2070Glu Ala Ile Asp Glu Leu Gly Ser Val Leu Lys Glu Ala Leu Lys Leu
670 675 680TTG CAC CCT TTC ATG CCC TTT ATC AGC GAG TCT TTA TAC CAC AAG CTC 2118Leu His Pro Phe Met Pro Phe Ile Ser Glu Ser Leu Tyr His Lys Leu
685 690 695AGC AAT ACG GAA CTA GAA AAC ACT GAA TCT ATC ATG GTC ATG CCT TAC 2166Ser Asn Thr Glu Leu Glu Asn Thr Glu Ser Ile Met Val Met Pro Tyr
700705 710CCT AAA GAT TTG GCG CAA GAT GAA AAA TTA GAG CAT GAA TTT GAA GTG 2214Pro Lys Asp Leu Ala Gln Asp Glu Lys Leu Glu His Glu Phe Glu Val
715 720 725ATT AAA GAT TGC ATT GTG TCT TTA AGG CGT TTA AAA ATC ATG CTA GAA 2262Ile Lys Asp Cys Ile Val Ser Leu Arg Arg Leu Lys Ile Met Leu Glu730 735 740 745ACC CCA CCG ATT GTT CTA AAA GAA GCG AGC GTG GGA TTA AGA GAA GCC 2310Thr Pro Pro Ile Val Leu Lys Glu Ala Ser Val Gly Leu Arg Glu Ala
750 755 760ATA GAA AAC ACA GAG CGT TTG CAA ACT TAC GCC CAA AAA TTA GCG AGG 2358Ile Glu Asn Thr Glu Arg Leu Gln Thr Tyr Ala Gln Lys Leu Ala Arg
765 770 775TTG GAA AAA GTC AGC GTG ATT AGT TCT AAG CCT TTA AAA AGC GTG AGC 2406Leu Glu Lys Val Ser Val Ile Ser Ser Lys Pro Leu Lys Ser Val Ser
780 785 790GAT GTG GGG GAA TTT TGC CAG ACT TAT GCG AAT TTA GAA AAT CTT GAT 2454Asp Val Gly Glu Phe Cys Gln Thr Tyr Ala Asn Leu Glu Asn Leu Asp
795 800 805TTA AGC CCG CTT GTT GCG CGT TTG AAA AAG CAG TTG GAA AAA TTG GAA 2502Leu Ser Pro Leu Val Ala Arg Leu Lys Lys Gln Leu Glu Lys Leu Glu810 815 820 825AAA GAA AAA TTA AAA CTC AAT TTG CAC AAT GAA AAT TTT GTC AAA AAC 2550Lys Glu Lys Leu Lys Leu Asn Leu His Asn Glu Asn Phe Val Lys Asn
830 835 840GCG CCT AAA AGC GTG CTA GAA AAA GCT AAA GAG AGT TTA AAA ACG CTT 2598Ala Pro Lys Ser Val Leu Glu Lys Ala Lys Glu Ser Leu Lys Thr Leu
845 850 855TTA GAA AAA GAA AGT AAA ATT AAG CAA GAA TTGGAC TTG TTA GAA CAA 2646Leu Glu Lys Glu Ser Lys Ile Lys Gln Glu Leu Asp Leu Leu Glu Gln
860865870 CCA TAATAAAAGG ATAGAAAATG TTTCAAGCGT TAAGCGATGG GTTTAAAAAC GCGCTC 2705ProAATAAAATCC G2716 (2) sequence 996 data: (i) sequence characteristics: length (A): 874 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 996: met Ile Met Lys Gln Glu Pro Thr Thr Tyr Gln Pro Glu Glu Ile Glu 151015 Lys Lys Ile Tyr Glu Ile Cys Ser His Arg Gly Tyr Phe Glu Ile Asp
20 25 30Gly Asn Glu Ala Ile Gln Glu Lys Asn Lys Arg Phe Cys Leu Met Met
35 40 45Pro Pro Pro Asn Val Thr Gly Val Leu His Ile Gly His Ala Leu Thr
50 55 60Leu Ser Leu Gln Asp Ile Leu Ala Arg Tyr Lys Arg Met Asp Gly Tyr65 70 75 80Lys Thr Leu Tyr Gln Pro Gly Leu Asp His Ala Gly Ile Ala Thr Gln
85 90 95Asn Val Val Glu Lys Gln Leu Leu Ser Gln Gly Ile Lys Lys Glu Asp
100 105 110Leu Gly Arg Glu Glu Phe Ile Lys Lys Val Trp Glu Trp Lys Glu Lys
115 120 125Ser Gly Gly Ala Ile Leu Glu Gln Met Lys Arg Leu Gly Val Ser Ala
130 135 140Ala Phe Ser Arg Thr Arg Phe Thr Met Asp Lys Gly Leu Gln Arg Ala145 150 155 160Val Lys Leu Ala Phe Leu Lys Trp Tyr Glu Lys Gly Leu Ile Ile Gln
165 170 175Asp Asn Tyr Met Val Asn Trp Cys Thr Lys Asp Gly AlaLeu Ser Asp
180 185 190Ile Glu Val Glu Tyr Glu Glu Arg Lys Gly Ala Leu Tyr Tyr Ile Arg
195 200 205Tyr Tyr Leu Glu Asn Gln Lys Asp Tyr Leu Val Val Ala Thr Thr Arg
210 215 220Pro Glu Thr Leu Phe Gly Asp Ser Ala Leu Met Val Asn Pro Asn Asp225 230 235 240Glu Arg Tyr Lys His Leu Val Gly Gln Lys Ala Ile Leu Pro Leu Ile
245 250 255His Arg Thr Ile Pro Ile Ile Ala Asp Glu His Val Glu Met Glu Phe
260 265 270Gly Thr Gly Cys Val Lys Val Thr Pro Gly His Asp Phe Asn Asp Tyr
275 280 285Glu Val Gly Lys Arg His His Leu Glu Thr Ile Lys Ile Phe Asp Glu
290 295 300Lys Gly Ile Leu Asn Ala His Cys Gly Glu Phe Glu Asn Leu Glu Arg305 310 315 320Leu Glu Ala Arg Asp Lys Val Val Glu Arg Leu Lys Glu Asn Ala Leu
325 330 335Leu Glu Lys Ile Glu Glu His Thr His Gln Val Gly His Cys Tyr Arg
340 345 350Cys His Asn Val Val Glu Pro Tyr Val Ser Lys Gln Trp Phe Val Lys
355 360 365Pro Glu Ile Ala Gln Ser Ser Ile Glu Lys Ile Gln Gln Gly Leu Ala
370 375 380Arg Phe Tyr Pro Sar Asn Trp Ile Asn Asn Tyr Asn Ala Trp Met Arg385 390 395 400Glu Leu Arg Pro Trp Cys Ile Ser Arg Gln Leu Phe Trp Gly His Gln
405 410 415Ile Pro Val Phe Thr Cys Glu Asn Asn His Gln Phe Val Ser Leu Asp
420 425 430Thr Pro Leu Ser Cys Pro Thr Cys Lys Ser Glu Thr Leu Glu Gln Asp
435 440 445Lys Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Trp Ala Phe Ser
450 455 460Thr Leu Gly Trp Gly Gln Glu Lys Ser Gly Leu Phe Asn Glu Ser Asp465 470 475 480Leu Lys Asp Phe Tyr Pro Asn Thr Thr Leu Ile Thr Gly Phe Asp Ile
485 490 495Leu Phe Phe Trp Val Ala Arg Met Leu Phe Cys Ser Glu Ser Leu Leu
500 505 510Gly Glu Leu Pro Phe Lys Asp Ile Tyr Leu His Ala Leu Val Arg Asp
515 520 525Glu Lys Gly Glu Lys Met Ser Lys Ser Lys Gly Asn Val Ile Asp Pro
530 535 540Leu Glu Met Ile Glu Lys Tyr Gly Ala Asp Ser Leu Arg Phe Thr Leu545 550 555 560Ala Asn Leu Cys Ala Thr Gly Arg Asp Ile Lys Leu Ser Thr Thr His
565 570 575Leu Glu Asn Asn Lys Asn Phe Ala Asn Lys Leu Phe Asn Ala Ala Ser
580 585 590Tyr Leu Lys Leu Lys Gln Glu Ser Phe Lys Asp Lys Glu Arg Leu Asn
595 600 605Glu Tyr Gln Thr Pro Leu Gly Arg Tyr Ala Lys Ser Arg Leu Asn Ser
610 615 620Ala Thr Lys Glu Ala Arg Asn Ala Leu AspAsn Tyr Arg Phe Asn Asp625 630 635 640Ala Thr Thr Leu Leu Tyr Arg Phe Leu Trp Gly Glu Phe Cys Asp Trp
645 650 655Phe Ile Glu Phe Ser Lys Val Glu Asn Glu Ala Ile Asp Glu Leu Gly
660 665 670Ser Val Leu Lys Glu Ala Leu Lys Leu Leu His Pro Phe Met Pro Phe
675 680 685Ile Ser Glu Ser Leu Tyr His Lys Leu Ser Asn Thr Glu Leu Glu Asn
690 695 700Thr Glu Ser Ile Met Val Met Pro Tyr Pro Lys Asp Leu Ala Gln Asp705 710 715 720Glu Lys Leu Glu His Glu Phe Glu Val Ile Lys Asp Cys Ile Val Ser
725 730 735Leu Arg Arg Leu Lys Ile Met Leu Glu Thr Pro Pro Ile Val Leu Lys
740 745 750Glu Ala Ser Val Gly Leu Arg Glu Ala Ile Glu Asn Thr Glu Arg Leu
755 760 765Gln Thr Tyr Ala Gln Lys Leu Ala Arg Leu Glu Lys Val Ser Val Ile
770 775 780Ser Ser Lys Pro Leu Lys Ser Val Ser Asp Val Gly Glu Phe Cys Gln785 790 795 800Thr Tyr Ala Asn Leu Glu Asn Leu Asp Leu Ser Pro Leu Val Ala Arg
805 810 815Leu Lys Lys Gln Leu Glu Lys Leu Glu Lys Glu Lys Leu Lys Leu Asn
820 825 830Leu His Asn Glu Asn Phe Val Lys Asn Ala Pro Lys Ser Val Leu Glu
835 840 845Lys Ala Lys Glu SerLeu Lys Thr Leu Leu Glu Lys Glu Ser Lys Ile
850855860 Lys Gln Glu Leu Asp Leu Leu Glu Gln Pro 865870 (2) sequence 997 data: (i) sequence characteristics: length (A): 509bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 451 (D) other information: (xi) Description of the sequence: sequence 997: GGGCTTTTTT AAACTTCTTC TTATATCTTT A ATG CTA GAA ATA GAC AAC CAA 52
Met Leu Glu Ile Asp Asn Gln
1 5 ACC CCG CTA GAA TCA GAC TTT TTA TTA TTA GAA AAA ATC GCA AAT GTT 100Thr Pro Leu Glu Ser Asp Phe Leu Leu Leu Glu Lys Ile Ala Asn Val
10 15 20TTA GCC CCC ACT CAA ATC ATT GAG CTT GTT TTG GTG AGC GAT GAA ACC 148Leu Ala Pro Thr Gln Ile Ile Glu Leu Val Leu Val Ser Asp Glu Thr
25 30 35ATT CGA GAA ATC AAC AAG GAT TTA AGG GGT TGC GAT TAC GCT ACC GAT 196Ile Arg Glu Ile Asn Lys Asp Leu Arg Gly Cys Asp Tyr Ala Thr Asp40 45 50 55GTT TTG AGC TTC CCT TTA GAA GCC ATT CCT CAC ACC CCT TTA GGG AGC 244Val Leu Ser Phe Pro Leu Glu Ala Ile Pro His Thr Pro Leu Gly Ser
60 65 70GTG GTG ATT AAT GCG CCA TTA GCT CAA ACT AAC GCT CTG AAA TTA GGA 292Val Val Ile Asn Ala Pro Leu Ala Gln Thr Asn Ala Leu Lys Leu Gly
75 80 85CAT AGC TTA GAA AAT GAG ATC GCT CTT TTA TTC ATT CAT GGG GTG TTG 340His Ser Leu Glu Asn Glu Ile Ala Leu Leu Phe Ile His Gly Val Leu
90 95 100CAT TTG TTG GGC TATGAC CAT GAA AAA GAT AAG GGC GAA CAA CGC CAA 388His Leu Leu Gly Tyr Asp His Glu Lys Asp Lys Gly Glu Gln Arg Gln
105 110 115AAA GAG AGC GAA CTC ATT AAA GCG TTT AAC TTG CCT TTG AGT TTG ATT 436Lys Glu Ser Glu Leu Ile Lys Ala Phe Asn Leu Pro Leu Ser Leu Ile120 125 130 135GAA CGC ACA CAG GAT TAGGTTTAGA TACTCTACTA ATGCTGACAA ATAAAGCTTT T 492Glu Arg Thr Gln Asp
140AATTTTTAAG AATGGAA 509 (2) sequence 998 data: (i) sequence characteristics: length (A): 140 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 998: met Leu Glu Ile Asp Asn Gln Thr Pro Leu Glu Ser Asp Phe Leu Leu 151015 Leu Glu Lys Ile Ala Asn Val Leu Ala Pro Thr Gln Ile Ile Glu Leu
20 25 30Val Leu Val Ser Asp Glu Thr Ile Arg Glu Ile Asn Lys Asp Leu Arg
35 40 45Gly Cys Asp Tyr Ala Thr Asp Val Leu Ser Phe Pro Leu Glu Ala Ile
50 55 60Pro His Thr Pro Leu Gly Ser Val Val Ile Asn Ala Pro Leu Ala Gln65 70 75 80Thr Asn Ala Leu Lys Leu Gly His Ser Leu Glu Asn Glu Ile Ala Leu
85 90 95Leu Phe Ile His Gly Val Leu His Leu Leu Gly Tyr Asp His Glu Lys
100 105 110Asp Lys Gly Glu Gln Arg Gln Lys Glu Ser Glu Leu Ile Lys Ala Phe
115 120 125Asn Leu Pro Leu Ser Leu Ile Glu Arg Thr Gln Asp
130135140 (2) sequence 999 data: (i) sequence characteristics: length (A): 1038bp(B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 996 (D) other information: (xi) Description of the sequence: sequence 999: AAAATTAAAA TAAAAAGGAT AGAA ATG AAT CAA GAA ATT TTA GAC GTG TTG 51
Met Asn Gln Glu Ile Leu Asp Val Leu
1 5ATA GTG GGT GCA GGG CCT GGG GGC ATT GCC ACG GCC GTA GAA TGC GAA 99Ile Val Gly Ala Gly Pro Gly Gly Ile Ala Thr Ala Val Glu Cys Glu10 15 20 25ATA GCC GGC GTT AAA AAA GTG CTT TTA TGC GAA AAA ACC GAA AGC CAT 147Ile Ala Gly Val Lys Lys Val Leu Leu Cys Glu Lys Thr Glu Ser His
30 35 40TCA GGC ATG TTA GAG AAG TTT TAT AAA GCC GGT AAA AGG ATT GAT AAA 195Ser Gly Met Leu Glu Lys Phe Tyr Lys Ala Gly Lys Arg Ile Asp Lys
45 50 55GAT TAT AAA AAG CAA GTC GTA GAG CTT AAA GGG CAT ATC CCT TTT AAA 243Asp Tyr Lys Lys Gln Val Val Glu Leu Lys Gly His Ile Pro Phe Lys
60 65 70GAC AGC TTT AAA GAA GAA ACT TTA GAG AAT TTC ACT AAC CTT TTA AAA 291Asp Ser Phe Lys Glu Glu Thr Leu Glu Asn Phe Thr Asn Leu Leu Lys
75 80 85GAG CAT CAC ATC ACG CCA AGC TAT AAA ACC GAT ATT GAG AGC GTG AAA 339Glu His His Ile Thr Pro Ser Tyr Lys Thr Asp Ile Glu Ser Val Lys90 95 100 105AAA GAG GGC GAA TAC TTT AAA ATC ACC ACC ACT TCT AAC ACA ACC TAT 387Lys Glu Gly Glu Tyr Phe Lys Ile Thr Thr Thr Ser Asn Thr Thr Tyr
110 115 120CAT GCT AAA TTC GTG GTG GTT GCG ATC GGG AAA ATG GGC CAG CCA AAC 435His Ala Lys Phe Val Val Val Ala Ile Gly Lys Met Gly Gln Pro Asn
125 130 135CGC CCT ACT GCT TAT AAA ATC CCT GTT GCG CTC TCT AAA CAA GTG GTT 483Arg Pro Thr Ala Tyr Lys Ile Pro Val Ala Leu Ser Lys Gln Val Val
140 145 150TTT AGC ATC AAT GAT TGT AAG GAA AAT GAA AAA ACC CTT GTG ATC GGC 531Phe Ser Ile Asn Asp Cys Lys Glu Asn Glu Lys Thr Leu Val Ile Gly
155 160 165GGA GGC AAC TCA GCG GTG GAA TAC GCC ATT GCT TTG TGC AAA ACC ACC 579Gly Gly Asn Ser Ala Val Glu Tyr Ala Ile Ala Leu Cys Lys Thr Thr170 175 180 185CCT ACC ACC CTC AAT TAC CGC AAA AAA GAA TTC AGC CGC ATC AAT GAA 627Pro Thr Thr Leu Asn Tyr Arg Lys Lys Glu Phe Ser Arg Ile Asn Glu
190 195 200GAC AAC GCT AAA AAC TTG CAA GAA GTC CTA AAC AAT AAC ACG CTT AAA 675Asp Asn Ala Lys Asn Leu Gln Glu Val Leu Asn Asn Asn Thr Leu Lys
205 210 215AGC AAG CTT GGA GTG GAT ATT GAA AGC CTA GAA GAA GAT AAC ACT CAG 723Ser Lys Leu Gly Val Asp Ile Glu Ser Leu Glu Glu Asp Asn Thr Gln
220 225 230ATT AAG GTT AAC TTC ACC GAT AAC ACG AGC GAA AGT TTT GAT CGT TTG 771Ile Lys Val Asn Phe Thr Asp Asn Thr Ser Glu Ser Phe Asp Arg Leu
235 240 245CTG TAT GCG ATC GGC GGC TCT ACC CCT TTA GAG TTT TTT AAA CGC TGT 819Leu Tyr Ala Ile Gly Gly Ser Thr Pro Leu Glu Phe Phe Lys Arg Cys250 255 260 265TCT TTA GAG CTG GAT CCT AGC ACC AAT ATC CCT GTG GTG AAA GAA AAT 867Ser Leu Glu Leu Asp Pro Ser Thr Asn Ile Pro Val ValLys Glu Asn
270 275 280TTA GAG AGC AAC AAT ATC CCT AAT TTG TTC ATC GTG GGC GAT ATT TTA 915Leu Glu Ser Asn Asn Ile Pro Asn Leu Phe Ile Val Gly Asp Ile Leu
285 290 295TTC AAA TCA GGG GCG AGC ATC GCT ACC GCT TTA AAC CAT GGC TAT GAT 963Phe Lys Ser Gly Ala Ser Ile Ala Thr Ala Leu Asn His Gly Tyr Asp
300 305 310GTT GCT ATA GAA ATC GCT AAA AGG TTG CAC TCT TAAAGCCGCT CACTCATCAA 1016Val Ala Ile Glu Ile Ala Lys Arg Leu His Ser
315320 ACGGCTTAGC CTTATACAAA AA 1038 (2) sequence 1000 data: (i) sequence characteristics: length (A): 324 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1000: met Asn Gln Glu Ile Leu Asp Val Leu Ile Val Gly Ala Gly Pro Gly 151015 Gly Ile Ala Thr Ala Val Glu Cys Glu Ile Ala Gly Val Lys Lys Val
20 25 30Leu Leu Cys Glu Lys Thr Glu Ser His Ser Gly Met Leu Glu Lys Phe
35 40 45Tyr Lys Ala Gly Lys Arg Ile Asp Lys Asp Tyr Lys Lys Gln Val Val
50 55 60Glu Leu Lys Gly His Ile Pro Phe Lys Asp Ser Phe Lys Glu Glu Thr65 70 75 80Leu Glu Asn Phe Thr Asn Leu Leu Lys Glu His His Ile Thr Pro Ser
85 90 95Tyr Lys Thr Asp Ile Glu Ser Val Lys Lys Glu Gly Glu Tyr Phe Lys
100 105 110Ile Thr Thr Thr Ser Asn Thr Thr Tyr His Ala Lys Phe Val Val Val
115120 125Ala Ile Gly Lys Met Gly Gln Pro Asn Arg Pro Thr Ala Tyr Lys Ile
130 135 140Pro Val Ala Leu Ser Lys Gln Val Val Phe Ser Ile Asn Asp Cys Lys145 150 155 160Glu Asn Glu Lys Thr Leu Val Ile Gly Gly Gly Asn Ser Ala Val Glu
165 170 175Tyr Ala Ile Ala Leu Cys Lys Thr Thr Pro Thr Thr Leu Asn Tyr Arg
180 185 190Lys Lys Glu Phe Ser Arg Ile Asn Glu Asp Asn Ala Lys Asn Leu Gln
195 200 205Glu Val Leu Asn Asn Asn Thr Leu Lys Ser Lys Leu Gly Val Asp Ile
210 215 220Glu Ser Leu Glu Glu Asp Asn Thr Gln Ile Lys Val Asn Phe Thr Asp225 230 235 240Asn Thr Ser Glu Ser Phe Asp Arg Leu Leu Tyr Ala Ile Gly Gly Ser
245 250 255Thr Pro Leu Glu Phe Phe Lys Arg Cys Ser Leu Glu Leu Asp Pro Ser
260 265 270Thr Asn Ile Pro Val Val Lys Glu Asn Leu Glu Ser Asn Asn Ile Pro
275 280 285Asn Leu Phe Ile Val Gly Asp Ile Leu Phe Lys Ser Gly Ala Ser Ile
290295300 Ala Thr Ala Leu Asn His Gly Tyr Asp Val Ala Ile Glu Ile Ala Lys 305310315320 Arg Leu His Ser (2) sequence 1001 data: (i) sequence characteristics: length (A): 704bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 670 (D) other information: (xi) Description of the sequence: sequence 1001: ATTTTTAAGG TATAGCGTT ATG GCA TTA GAT TGG GAT TTT ATG TTT CAC TCC 52
Met Ala Leu Asp Trp Asp Phe Met Phe His Ser
1 5 10ATC CCT GCG TTT TTT AAG GGG TTA GAA CTC ACG CTT TAT ATT TCT TTC 100Ile Pro Ala Phe Phe Lys Gly Leu Glu Leu Thr Leu Tyr Ile Ser Phe
15 20 25TTT GGG ATT TTG CTC TCT CTT TTG GTG GGG TTT TTG TGC GCG ATC GTT 148Phe Gly Ile Leu Leu Ser Leu Leu Val Gly Phe Leu Cys Ala Ile Val
30 35 40TTG TAT TTT AAA ACG CGC TTT CTC TCT CCT GTT GTC TAT ATC TAT GGC 196Leu Tyr Phe Lys Thr Arg Phe Leu Ser Pro Val Val Tyr Ile Tyr Gly
45 50 55GAA ATC GCT AGG AAC ACG CCC CTG CTC ATC CAG CTT TTC TTT TTG TAT 244Glu Ile Ala Arg Asn Thr Pro Leu Leu Ile Gln Leu Phe Phe Leu Tyr60 65 70 75TAC GGG TTG AAT GAA ATC GGT TTG AGC GCT TTA GAG TGC GCG ATT TTA 292Tyr Gly Leu Asn Glu Ile Gly Leu Ser Ala Leu Glu Cys Ala Ile Leu
80 85 90GCG TTA GGG TTT TTG GGT GGG GGG TAT ATG AGT CAA AGT TTT TTG CTT 340Ala Leu Gly Phe Leu Gly Gly Gly Tyr Met Ser Gln Ser Phe Leu Leu
95 100 105GGG TTT AAG AGC CTA GCT TCC ATT CAA AGA GAA AGC GCT TTG AGT TTG 388Gly Phe Lys Ser Leu Ala Ser Ile Gln Arg Glu Ser Ala Leu Ser Leu
110 115 120GGG TTT AGC CCT TTG AAA ATG ATG TAT TAT ATT ATT CTG CCT CAA AGT 436Gly Phe Ser Pro Leu Lys Met Met Tyr Tyr Ile Ile Leu Pro Gln Ser
125 130 135TTA AGC GTT TCT ATG CCT TCC ATA GGG GCG AAT GTG ATT TTT TTA CTC 484Leu Ser Val Ser Met Pro Ser Ile Gly Ala Asn Val Ile Phe Leu Leu140 145 150 155AAA GAA ACT TCG GTG GTG GGC GCG ATA GCC CTA ACC GAT ATT ATG TTT 532Lys Glu Thr Ser Val Val Gly Ala Ile Ala Leu Thr Asp Ile Met Phe
160 165 170GTG GCG AAA GAT TTT ATT GGC ATT TAT TAT AAA ACG ACT GAA AGC CTT 580Val Ala Lys Asp Phe Ile Gly Ile Tyr Tyr Lys Thr Thr Glu Ser Leu
175 180 185TTG ATG TTA AGC CTC ACT TAT TTG ATC GCT TTA CTC CCT TTA AGC GTT 628Leu Met Leu Ser Leu Thr Tyr Leu Ile Ala Leu Leu Pro Leu Ser Val
190 195 200TTG TTT GTG ATC TTA GAG CGT TTC TTT AAA AAG AAA GTG GCT TAAAATGGG 679Leu Phe Val Ile Leu Glu Arg Phe Phe Lys Lys Lys Val Ala
205210215 AGTTTTACTA GAATTAGACA ACCTT 704 (2) sequence 1002 data: (i) sequence characteristics: length (A): 217 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1002: met Ala Leu Asp Trp Asp Phe Met Phe His Ser Ile Pro Ala Phe Phe 151015 Lys Gly Leu Glu Leu Thr Leu Tyr Ile Ser Phe Phe Gly Ile Leu Leu
20 25 30Ser Leu Leu Val Gly Phe Leu Cys Ala Ile Val Leu Tyr Phe Lys Thr
35 40 45Arg Phe Leu Ser Pro Val Val Tyr Ile Tyr Gly Glu Ile Ala Arg Asn
50 55 60Thr Pro Leu Leu Ile Gln Leu Phe Phe Leu Tyr Tyr Gly Leu Asn Glu65 70 75 80Ile Gly Leu Ser Ala Leu Glu Cys Ala Ile Leu Ala Leu Gly Phe Leu
85 9095Gly Gly Gly Tyr Met Ser Gln Ser Phe Leu Leu Gly Phe Lys Ser Leu
100 105 110Ala Ser Ile Gln Arg Glu Ser Ala Leu Ser Leu Gly Phe Ser Pro Leu
115 120 125Lys Met Met Tyr Tyr Ile Ile Leu Pro Gln Ser Leu Ser Val Ser Met
130 135 140Pro Ser Ile Gly Ala Asn Val Ile Phe Leu Leu Lys Glu Thr Ser Val145 150 155 160Val Gly Ala Ile Ala Leu Thr Asp Ile Met Phe Val Ala Lys Asp Phe
165 170 175Ile Gly Ile Tyr Tyr Lys Thr Thr Glu Ser Leu Leu Met Leu Ser Leu
180 185 190Thr Tyr Leu Ile Ala Leu Leu Pro Leu Ser Val Leu Phe Val Ile Leu
195 200 205Glu Arg Phe Phe Lys Lys Lys Val Ala
210215 (2) sequence 1003 data: (i) sequence characteristics: length (A): 737bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 699 (D) other information: (xi) Description of the sequence: sequence 1003: AGCGTTTCTT TAAAAAGAAA GTGGCTTAAA ATG GGA GTT TTA CTA GAA TTA GAC 54
Met Gly Val Leu Leu Glu Leu Asp
1 5AAC CTT AAG CGT TTG TTA GAA GGG TTT GAA ACC ACT CTT TTG ATC GCT 102Asn Leu Lys Arg Leu Leu Glu Gly Phe Glu Thr Thr Leu Leu Ile Ala
10 15 20CTT AGC TCT GCA ATG ATT TCA ATC ATT GTT GGA ATG CTT TTG GGG AGC 150Leu Ser Ser Ala Met IleSer Ile Ile Val Gly Met Leu Leu Gly Ser25 30 35 40TTG ATG GCG TTT GGT TCT CAA ATA GTG GTT TTG GCG TGT CGT GTG TAT 198Leu Met Ala Phe Gly Ser Gln Ile Val Val Leu Ala Cys Arg Val Tyr
45 50 55TTA GAA AGC ATT CGC ATC ATC CCG CTT TTA GCA TGG CTT TTT ATT GTG 246Leu Glu Ser Ile Arg Ile Ile Pro Leu Leu Ala Trp Leu Phe Ile Val
60 65 70TAT TTC GGG TTA GCG AGC TGG TTT GAT TTG CAT ATT AGC GCG GTT TTG 294Tyr Phe Gly Leu Ala Ser Trp Phe Asp Leu His Ile Ser Ala Val Leu
75 80 85GCA AGC GTT ATT GTT TTT AGC TTG TGG GGT GGC GCT GAA ATG ATG GAT 342Ala Ser Val Ile Val Phe Ser Leu Trp Gly Gly Ala Glu Met Met Asp
90 95 100TTA ACT AGG GGG GTT TTA ACT TCC GTG AGC AAA CAC CAA ATA GAA AGC 390Leu Thr Arg Gly Val Leu Thr Ser Val Ser Lys His Gln Ile Glu Ser105 110 115 120GCT CTG GCT TTA GGC TTA GAT TCA AAA AAG GTG ATT TTT AAT ATT ATT 438Ala Leu Ala Leu Gly Leu Asp Ser Lys Lys Val Ile Phe Asn Ile Ile
125 130 135TTC CCT CAA AGC TTT TTG TCT TTA TTG CCC TCA AGC CTT AAT TTG TTC 486Phe Pro Gln Ser Phe Leu Ser Leu Leu Pro Ser Ser Leu Asn Leu Phe
140 145 150ACG CGC ATG ATC AAA ACC ACG GCT TTA GTT TCT CTC ATT GGA GCG ATT 534Thr Arg Met Ile Lys Thr Thr Ala Leu Val Ser Leu Ile Gly Ala Ile
155 160 165GAT TTG CTA AAA GTG GGC CAG CAA ATC ATA GAG CTT AAC CTC TTA CGC 582Asp Leu Leu Lys Val Gly Gln Gln Ile Ile Glu Leu Asn Leu Leu Arg
170 175180ATG CCT AAT GCG AGC TTT GTG GTT TAT GGC GTT ATC TTA ATG TTT TAT 630Met Pro Asn Ala Ser Phe Val Val Tyr Gly Val Ile Leu Met Phe Tyr185 190 195 200TTT AGT TTA TGC TAT AGT TTG AGC CTG TAT AGT TCC TAT TTA GAA AAA 678Phe Ser Leu Cys Tyr Ser Leu Ser Leu Tyr Ser Ser Tyr Leu Glu Lys
205 210 215AAA TTC CAA CAC ATT AGA GGG TAAAATGAGC GTGATTTTAG AAACCAAAGG GTTA 733Lys Phe Gln His Ile Arg Gly
220AAAA 737 (2) data of sequence 1004: (i) sequence characteristics: length (A): 223 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1004: met Gly Val Leu Leu Glu Leu Asp Asn Leu Lys Arg Leu Leu Glu Gly 151015 Phe Glu Thr Thr Leu Leu Ile Ala Leu Ser Ser Ala Met Ile Ser Ile
20 25 30Ile Val Gly Met Leu Leu Gly Ser Leu Met Ala Phe Gly Ser Gln Ile
35 40 45Val Val Leu Ala Cys Arg Val Tyr Leu Glu Ser Ile Arg Ile Ile Pro
50 55 60Leu Leu Ala Trp Leu Phe Ile Val Tyr Phe Gly Leu Ala Ser Trp Phe65 70 75 80Asp Leu His Ile Ser Ala Val Leu Ala Ser Val Ile Val Phe Ser Leu
85 90 95Trp Gly Gly Ala Glu Met Met Asp Leu Thr Arg Gly Val Leu Thr Ser
100 105 110Val Ser Lys His Gln Ile Glu Ser Ala Leu Ala Leu Gly Leu Asp Ser
115 120 125Lys Lys Val Ile Phe Asn Ile Ile Phe Pro Gln Ser Phe Leu Ser Leu
130135 140Leu Pro Ser Ser Leu Asn Leu Phe Thr Arg Met Ile Lys Thr Thr Ala145 150 155 160Leu Val Ser Leu Ile Gly Ala Ile Asp Leu Leu Lys Val Gly Gln Gln
165 170 175Ile Ile Glu Leu Asn Leu Leu Arg Met Pro Asn Ala Ser Phe Val Val
180 185 190Tyr Gly Val Ile Leu Met Phe Tyr Phe Ser Leu Cys Tyr Ser Leu Ser
195 200 205Leu Tyr Ser Ser Tyr Leu Glu Lys Lys Phe Gln His Ile Arg Gly
210215220 (2) sequence 1005 data: (i) sequence characteristics: length (A): 807bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 774 (D) other information: (xi) Description of the sequence: sequence 1005: AAAAAAAATT CCAACACATT AGAGGGTAAA ATG AGC GTG ATT TTA GAA ACC AAA 54
Met Ser Val Ile Leu Glu Thr Lys
1 5GGG TTA AAA AAA ACC TAT CAA AAC CAT TTG GTT TTA GAC GGC ATC AAT 102Gly Leu Lys Lys Thr Tyr Gln Asn His Leu Val Leu Asp Gly Ile Asn
10 15 20TTC ACT TTA AAT AAG GGT GAA GTG GCA GTG ATT TTA GGG CCT AGC GGG 150Phe Thr Leu Asn Lys Gly Glu Val Ala Val Ile Leu Gly Pro Ser Gly25 30 35 40TGC GGG AAA AGC ACT TTT TTA AAA TGC CTA AAC GGG CTT GAA AAG ATT 198Cys Gly Lys Ser Thr Phe Leu Lys Cys Leu Asn Gly Leu Glu Lys Ile
45 50 55AAT GAA GGT GAA ATC CTT TTT GAA AAC ACT AAC CTT AAC AAT AAG GCC 246AsnGlu Gly Glu Ile Leu Phe Glu Asn Thr Asn Leu Asn Asn Lys Ala
60 65 70ACT AAC TGG AAT CAA ATG CGC CAA AAA ATA GGC ATG GTG TTT CAA AAT 294Thr Asn Trp Asn Gln Met Arg Gln Lys Ile Gly Met Val Phe Gln Asn
75 80 85TAT GAA TTG TTC CCG CAT TTA AAT GTG TTA GAT AAT ATC TTA CTC GCT 342Tyr Glu Leu Phe Pro His Leu Asn Val Leu Asp Asn Ile Leu Leu Ala
90 95 100CCT ATG AAA GTG CAA AAA CGA TCC AAA GAT GAG GTT ATT TCT CAA GCC 390Pro Met Lys Val Gln Lys Arg Ser Lys Asp Glu Val Ile Ser Gln Ala105 110 115 120ATA GAG CTT TTA AAG CGA GTG GGT TTG GAG CAT AAA CAA CAA GCT TAC 438Ile Glu Leu Leu Lys Arg Val Gly Leu Glu His Lys Gln Gln Ala Tyr
125 130 135CCT AAA GAA TTG AGC GGC GGA CAA AAA CAA CGA GTA GCG ATC GTG CGC 486Pro Lys Glu Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Val Arg
140 145 150TCT TTA TGC ATG CGA CCA AAA ATC ATG CTT TTT GAT GAA GTA ACC GCC 534Ser Leu Cys Met Arg Pro Lys Ile Met Leu Phe Asp Glu Val Thr Ala
155 160 165TCT TTA GAC CCT GAA ATG GTT AAA GAA GTT TTA GAA GTG ATT TTA GAA 582Ser Leu Asp Pro Glu Met Val Lys Glu Val Leu Glu Val Ile Leu Glu
170 175 180TTA GCC ACA ACA GGC ATG AGC ATG GTG ATT GTA ACG CAT GAA ATG AAA 630Leu Ala Thr Thr Gly Met Ser Met Val Ile Val Thr His Glu Met Lys185 190 195 200TTC GCG CAA AAA ATC GCT CAT AAA ATC GTG TTT TTT GAT AGC GGT AAA 678Phe Ala Gln Lys Ile Ala His Lys Ile Val Phe Phe Asp Ser Gly Lys
205210 215ATC GCT GAA GAA AAC AAC GCT AAA GAA TTT TTT AAC CAC CCG AAA TCT 726Ile Ala Glu Glu Asn Asn Ala Lys Glu Phe Phe Asn His Pro Lys Ser
220 225 230CAA AGA GCG CAA AAA TTT TTA GAA ACT TTC CAT TTT TTA GGG AGC TGT T 775Gln Arg Ala Gln Lys Phe Leu Glu Thr Phe His Phe Leu Gly Ser Cys
235240245 AAATAAAGTT TGCTAAAAAG ATGATTCTAA TT 807 (807) (2) sequence 1006 data: (i) sequence characteristics: length (A): 248 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1006: met Ser Val Ile Leu Glu Thr Lys Gly Leu Lys Lys Thr Tyr Gln Asn 151015 His Leu Val Leu Asp Gly Ile Asn Phe Thr Leu Asn Lys Gly Glu Val
20 25 30Ala Val Ile Leu Gly Pro Ser Gly Cys Gly Lys Ser Thr Phe Leu Lys
35 40 45Cys Leu Asn Gly Leu Glu Lys Ile Asn Glu Gly Glu Ile Leu Phe Glu
50 55 60Asn Thr Asn Leu Asn Asn Lys Ala Thr Asn Trp Asn Gln Met Arg Gln65 70 75 80Lys Ile Gly Met Val Phe Gln Asn Tyr Glu Leu Phe Pro His Leu Asn
85 90 95Val Leu Asp Asn Ile Leu Leu Ala Pro Met Lys Val Gln Lys Arg Ser
100 105 110Lys Asp Glu Val Ile Ser Gln Ala Ile Glu Leu Leu Lys Arg Val Gly
115 120 125Leu Glu His Lys Gln Gln Ala Tyr Pro Lys Glu Leu Ser Gly Gly Gln
130 135 140Lys Gln Arg Val Ala Ile Val Arg Ser Leu Cys Met Arg Pro Lys Ile145150 155 160Met Leu Phe Asp Glu Val Thr Ala Ser Leu Asp Pro Glu Met Val Lys
165 170 175Glu Val Leu Glu Val Ile Leu Glu Leu Ala Thr Thr Gly Met Ser Met
180 185 190Val Ile Val Thr His Glu Met Lys Phe Ala Gln Lys Ile Ala His Lys
195 200 205Ile Val Phe Phe Asp Ser Gly Lys Ile Ala Glu Glu Asn Asn Ala Lys
210 215 220Glu Phe Phe Asn His Pro Lys Ser Gln Arg Ala Gln Lys Phe Leu Glu225 230 235 240Thr Phe His Phe Leu Gly Ser Cys
245 (2) sequence 1007 data: (i) sequence characteristics: length (A): 589bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 561 (D) other information: (xi) Description of the sequence: sequence 1007: AAGGATTTGT TG ATG AGT TAT TTT TAT AAG CAC TGT TTG AAA TTT TCG TTG 51
Met Ser Tyr Phe Tyr Lys His Cys Leu Lys Phe Ser Leu
1 5 10GTT GGG TTG CTA GGG CTT TTG AGC GTT CAG CTT GAC GCT AGG AGT TTT 99Val Gly Leu Leu Gly Leu Leu Ser Val Gln Leu Asp Ala Arg Ser Phe
15 20 25GTT GAT GGG GAT TTA GAC ATT CAG AAA TTC AGC TAT GAA GAT TCT CTA 147Val Asp Gly Asp Leu Asp Ile Gln Lys Phe Ser Tyr Glu Asp Ser Leu30 35 40 45CTT AAA AAG GGA GAC CCT AAT GGC GTG CAT AAA GTG CAG GTG CGA GAT 195Leu Lys Lys Gly Asp Pro Asn Gly Val His Lys Val Gln Val Arg Asp
5055 60TAT AAA GGC AAA ATG CAA GAA GCT GAG ATC CAC TCA GAA ATA CGC ATT 243Tyr Lys Gly Lys Met Gln Glu Ala Glu Ile His Ser Glu Ile Arg Ile
65 70 75GCG CTT AAA CCG GGG GTT AAA AAA GAA GTT AAA AAA GGC AAG ATT TAT 291Ala Leu Lys Pro Gly Val Lys Lys Glu Val Lys Lys Gly Lys Ile Tyr
80 85 90AGC GCT CAA ATC AAT GAT GGC ATG TGC TAT GCT TTT AGA ATG CTC CAA 339Ser Ala Gln Ile Asn Asp Gly Met Cys Tyr Ala Phe Arg Met Leu Gln
95 100 105ACC GGC GAT AAT ACC ACA GGC CTT GAT TCT AAA GAG TTC CCC AAG CAA 387Thr Gly Asp Asn Thr Thr Gly Leu Asp Ser Lys Glu Phe Pro Lys Gln110 115 120 125AGT CGT GAG AAA AAG GGC CGA GTG ATC ACT TTA ATC GGT AAA GGT GAA 435Ser Arg Glu Lys Lys Gly Arg Val Ile Thr Leu Ile Gly Lys Gly Glu
130 135 140GTG CCT TAT CTT ATT TTA GAA ACC GAT TGC CAA GTG GGT GAT ATT GCA 483Val Pro Tyr Leu Ile Leu Glu Thr Asp Cys Gln Val Gly Asp Ile Ala
145 150 155AAG ATC TCT TTG GTG GGT AAT TTT GAT GGC ACT GGG TTT CTT ACG GAA 531Lys Ile Ser Leu Val Gly Asn Phe Asp Gly Thr Gly Phe Leu Thr Glu
160 165 170TAT AAA TTC AAA GAC GCT AAA CCC ATT TAC TAGTCTTTAT TCTTCGCTTC ATT 584Tyr Lys Phe Lys Asp Ala Lys Pro Ile Tyr
175180 CTTAA 589 (2) sequence 1008 data: (i) sequence characteristics: length (A): 183 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1008: met Ser Tyr Phe Tyr Lys His Cys Leu Lys Phe Ser Leu Val GlyLeu 151015 Leu Gly Leu Leu Ser Val Gln Leu Asp Ala Arg Ser Phe Val Asp Gly
20 25 30Asp Leu Asp Ile Gln Lys Phe Ser Tyr Glu Asp Ser Leu Leu Lys Lys
35 40 45Gly Asp Pro Asn Gly Val His Lys Val Gln Val Arg Asp Tyr Lys Gly
50 55 60Lys Met Gln Glu Ala Glu Ile His Ser Glu Ile Arg Ile Ala Leu Lys65 70 75 80Pro Gly Val Lys Lys Glu Val Lys Lys Gly Lys Ile Tyr Ser Ala Gln
85 90 95Ile Asn Asp Gly Met Cys Tyr Ala Phe Arg Met Leu Gln Thr Gly Asp
100 105 110Asn Thr Thr Gly Leu Asp Ser Lys Glu Phe Pro Lys Gln Ser Arg Glu
115 120 125Lys Lys Gly Arg Val Ile Thr Leu Ile Gly Lys Gly Glu Val Pro Tyr
130 135 140Leu Ile Leu Glu Thr Asp Cys Gln Val Gly Asp Ile Ala Lys Ile Ser145 150 155 160Leu Val Gly Asn Phe Asp Gly Thr Gly Phe Leu Thr Glu Tyr Lys Phe
165 170 175Lys Asp Ala Lys Pro Ile Tyr
180 (2) sequence 1009 data: (i) sequence characteristics: length (A): 925bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 875 (D) other information: (xi) Description of the sequence: sequence 1009: GGAATTTTTG GGTGCTACTC CTTTCTCGT ATG GGT ATC GCT TTT GCC CAC TCT 53
Met Gly Ile Ala Phe Ala His Ser
1 5ATT TTT TGG TCC ATC ACG GCT TCT TTA GTC ATT CGT GTC GCG CCA AGA 101Ile Phe Trp Ser Ile Thr Ala Ser Leu Val Ile Arg Val Ala Pro Arg
10 15 20AAT AAA AAA CAA CAG GCC TTA GGG CTG TTA GCG TTA GGG AGT TCG TTA 149Asn Lys Lys Gln Gln Ala Leu Gly Leu Leu Ala Leu Gly Ser Ser Leu25 30 35 40GCG ATG ATT TTA GGG TTG CCG CTT GGG AGG ATC ATT GGG CAA ATT CTA 197Ala Met Ile Leu Gly Leu Pro Leu Gly Arg Ile Ile Gly Gln Ile Leu
45 50 55GAT TGG CGT TCC ACT TTT GGC GTG ATC GGG GGC GTT GCG ACC CTT ATA 245Asp Trp Arg Ser Thr Phe Gly Val Ile Gly Gly Val Ala Thr Leu Ile
60 65 70GCG TTG CTT ATG TGG AAA TTG CTC CCG CAT CTA CCC AGT AGA AAC GCA 293Ala Leu Leu Met Trp Lys Leu Leu Pro His Leu Pro Ser Arg Asn Ala
75 80 85GGC ACG CTC GCA AGT GTC CCT GTA TTA ATG AAA CGG CCG CTT TTA ATG 341Gly Thr Leu Ala Ser Val Pro Val Leu Met Lys Arg Pro Leu Leu Met
90 95 100GGG ATT TAT TTG CTT GTG ATC ATG GTC ATC TCT GGG CAT TTC ACC ACT 389Gly Ile Tyr Leu Leu Val Ile Met Val Ile Ser Gly His Phe Thr Thr105 110 115 120TAT AGT TAT ATT GAG CCT TTT ATC ATT CAA ATC AGC CAA TTT TCT CCT 437Tyr Ser Tyr Ile Glu Pro Phe Ile Ile Gln Ile Ser Gln Phe Ser Pro
125 130 135GAC ATT ACA ACG CTA ATG TTG TTT GTG TTT GGG TTA GCG GGC GTG GTG 485Asp Ile Thr Thr Leu Met Leu Phe Val Phe Gly Leu Ala Gly Val Val
140 145 150GGG AGT TTT TTG TTC GGC CGTTTG TAT GCA AAA AAT TCA AGA AAA TTT 533Gly Ser Phe Leu Phe Gly Arg Leu Tyr Ala Lys Asn Ser Arg Lys Phe
155 160 165ATC GCT TTT GCG ATG GTT TTA GTC ATT TGC CCG CAA CTC TTG CTT TTT 581Ile Ala Phe Ala Met Val Leu Val Ile Cys Pro Gln Leu Leu Leu Phe
170 175 180GTG TTT AAA AAC TTA GAG TGG GTG GTT TTC TTG CAA ATT TTC TTA TGG 629Val Phe Lys Asn Leu Glu Trp Val Val Phe Leu Gln Ile Phe Leu Trp185 190 195 200GGG ATT GGG ATC ACT TCG CTT GGG ATT TCC TTG CAA ATG AGG GTG TTG 677Gly Ile Gly Ile Thr Ser Leu Gly Ile Ser Leu Gln Met Arg Val Leu
205 210 215CAG CTT GCG CCG GAT GCC ACG GAT GTT GCG AGT GCG ATT TAC TCA GGG 725Gln Leu Ala Pro Asp Ala Thr Asp Val Ala Ser Ala Ile Tyr Ser Gly
220 225 230AGC TAT AAT GTG GGG ATT GGA TCA GGA GCG CTG TTT GGC AGT ATT GTG 773Ser Tyr Asn Val Gly Ile Gly Ser Gly Ala Leu Phe Gly Ser Ile Val
235 240 245ATC CAC CAA CTA GGG CTA GGA TAT ATT GGC TTT GTG GGT GGG GCT TTA 821Ile His Gln Leu Gly Leu Gly Tyr Ile Gly Phe Val Gly Gly Ala Leu
250255260 GGT TTG TTG GCG CTC TTT TGG CTT AGA TTC ATT ACG ATA AAG TTT AAA 869Gly Leu Leu Ala Leu Phe Trp Leu Arg Phe Ile Thr Ile Lys Phe Lys 265270275280 AAA ACA TAAAGAGCGT TAAAAGGATT AGCCCAATAA AGGAGAATCC CTTTCGCACT 925Lys Thr (2) sequence 1010 data: (i) sequence characteristics: length (A): 282 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1010: met Gly Ile Ala Phe Ala His Ser Ile Phe Trp Ser Ile Thr Ala Ser 151015 Leu Val Ile Arg Val Ala Pro Arg Asn Lys Lys Gln Gln Ala Leu Gly
20 25 30Leu Leu Ala Leu Gly Ser Ser Leu Ala Met Ile Leu Gly Leu Pro Leu
35 40 45Gly Arg Ile Ile Gly Gln Ile Leu Asp Trp Arg Ser Thr Phe Gly Val
50 55 60Ile Gly Gly Val Ala Thr Leu Ile Ala Leu Leu Met Trp Lys Leu Leu65 70 75 80Pro His Leu Pro Ser Arg Asn Ala Gly Thr Leu Ala Ser Val Pro Val
85 90 95Leu Met Lys Arg Pro Leu Leu Met Gly Ile Tyr Leu Leu Val Ile Met
100 105 110Val Ile Ser Gly His Phe Thr Thr Tyr Ser Tyr Ile Glu Pro Phe Ile
115 120 125Ile Gln Ile Ser Gln Phe Ser Pro Asp Ile Thr Thr Leu Met Leu Phe
130 135 140Val Phe Gly Leu Ala Gly Val Val Gly Ser Phe Leu Phe Gly Arg Leu145 150 155 160Tyr Ala Lys Asn Ser Arg Lys Phe Ile Ala Phe Ala Met Val Leu Val
165 170 175Ile Cys Pro Gln Leu Leu Leu Phe Val Phe Lys Asn Leu Glu Trp Val
180 185 190Val Phe Leu Gln Ile Phe Leu Trp Gly Ile Gly Ile Thr Ser Leu Gly
195 200 205Ile Ser Leu Gln Met Arg Val Leu Gln Leu Ala Pro Asp Ala Thr Asp
210 215 220Val Ala Ser Ala Ile Tyr Ser Gly Ser Tyr Asn Val Gly Ile Gly Ser225 230 235 240Gly Ala Leu Phe Gly Ser Ile Val Ile His Gln Leu Gly Leu Gly Tyr
245 250 255Ile Gly Phe Val Gly Gly Ala Leu Gly Leu Leu Ala Leu Phe Trp Leu
260 265 270Arg Phe Ile Thr Ile Lys Phe Lys Lys Thr
275280 (2) data on sequence 1011: (i) sequence characteristics: length (A): 1097bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1065 (D) other information: (xi) Description of the sequence: sequence 1011: AAGCCCTTGA AATCATTGGA GAAAACG ATG AAG ACT TAT AAT GTC GCT ATT GTT 54
Met Lys Thr Tyr Asn Val Ala Ile Val
1 5GGG GCC AGT GGG GCG GTA GGC CAA GAG CTG ATT AAG GGT TTA GAA AAT 102Gly Ala Ser Gly Ala Val Gly Gln Glu Leu Ile Lys Gly Leu Glu Asn10 15 20 25TCT TTT TTC CCA ATT AAA AAA TTT GTC CCG CTC GCT AGC ACT AGG AGT 150Ser Phe Phe Pro Ile Lys Lys Phe Val Pro Leu Ala Ser Thr Arg Ser
30 35 40GCT GGT AAA AAG ATC AAA GCT TTC AAT AAA GAC TAT GAA ATT TTA GAA 198Ala Gly Lys Lys Ile Lys Ala Phe Asn Lys Asp Tyr Glu Ile Leu Glu
45 50 55ACC ACG CAT GAA GTT TTT GAA AGA GAA AAA ATA GAC ATC GCC TTT TTT 246Thr Thr His Glu Val Phe Glu Arg Glu Lys Ile Asp Ile Ala Phe Phe
60 65 70AGC GCT GGG GGG AGC GTG AGC GMA GAA TTT GCT ACA AGC GCT TCA AAA 294Ser Ala Gly Gly Ser Val Ser Xaa Glu Phe Ala Thr Ser Ala Ser Lys
75 80 85ACG GCC TTA GTG GTT GAT AAC ACG AGCTTT TTT AGA TTG AAT AAA GAT 342Thr Ala Leu Val Val Asp Asn Thr Ser Phe Phe Arg Leu Asn Lys Asp90 95 100 105GTG CCT TTA GTC GTT CCT GAA ATC AAC GCT AAA GAA ATT TTT AAC GCT 390Val Pro Leu Val Val Pro Glu Ile Asn Ala Lys Glu Ile Phe Asn Ala
110 115 120CCC TTG AAT ATC ATC GCT AAC CCT AAT TGC TCC ACC ATT CAA ATG ACG 438Pro Leu Asn Ile Ile Ala Asn Pro Asn Cys Ser Thr Ile Gln Met Thr
125 130 135CAA ATC TTA AAC CCC TTA CAT CTC CAT TTT AAG ATA AAA AGC GTG ATT 486Gln Ile Leu Asn Pro Leu His Leu His Phe Lys Ile Lys Ser Val Ile
140 145 150GTT AGC ACC TAT CAA GCC GTG AGT GGG GCA GGG AAC AAG GGC ATA GAG 534Val Ser Thr Tyr Gln Ala Val Ser Gly Ala Gly Asn Lys Gly Ile Glu
155 160 165AGT TTA AAA AAT GAG TTA AAA ACC GCT TTA GAG TGT TTG GAA AAA GAC 582Ser Leu Lys Asn Glu Leu Lys Thr Ala Leu Glu Cys Leu Glu Lys Asp170 175 180 185CCC ACT ATT GAT TTA AAC CAA GTC TTG CAA GCT GGG GCT TTC GCT TAT 630Pro Thr Ile Asp Leu Asn Gln Val Leu Gln Ala Gly Ala Phe Ala Tyr
190 195 200CCG ATC GCT TTC AAT GCG ATC GCT CAT ATT GAT ACT TTT AAG GAG AAT 678Pro Ile Ala Phe Asn Ala Ile Ala His Ile Asp Thr Phe Lys Glu Asn
205 210 215GGT TAC ACG AAA GAA GAG CTA AAA ATG CTG CAT GAA ACC CAT AAA ATC 726Gly Tyr Thr Lys Glu Glu Leu Lys Met Leu His Glu Thr His Lys Ile
220 225 230ATG GGC GTG GAT TTC CCT ATC AGC GCG ACT TGC GTG CGC GTG CCG GTA 774Met Gly Val Asp Phe Pro Ile SerAla Thr Cys Val Arg Val Pro Val
235 240 245TTG AGG AGC CAT AGC GAG AGT TTG AGT ATC GCT TTT GAA AAA GAA TTC 822Leu Arg Ser His Ser Glu Ser Leu Ser Ile Ala Phe Glu Lys Glu Phe250 255 260 265GAT CTC AAA GAA GTC TAT GAA GTT TTA AAA AAC GCC CCT AGC GTG GCT 870Asp Leu Lys Glu Val Tyr Glu Val Leu Lys Asn Ala Pro Ser Val Ala
270 275 280GTT TGC GAT GAT CCC AGT CAT AAT CTT TAC CCC ACG CCC CTA AAA GCG 918Val Cys Asp Asp Pro Ser His Asn Leu Tyr Pro Thr Pro Leu Lys Ala
285 290 295AGC CAC ACG GAT AGC GTC TTT ATA GGG CGC TTG AGG AAG GAT TTG TTT 966Ser His Thr Asp Ser Val Phe Ile Gly Arg Leu Arg Lys Asp Leu Phe
300 305 310GAT AAG AAA ACT TTG CAT GGC TTT TGT GTG GCG GAT CAA TTG AGA GTG 1014Asp Lys Lys Thr Leu His Gly Phe Cys Val Ala Asp Gln Leu Arg Val
315320325 GGG GCA GCC ACC AAC GCA CTC AAA ATC GCT CTG CAT TAC ATT AAG AAC 1062Gly Ala Ala Thr Asn Ala Leu Lys Ile Ala Leu His Tyr Ile Lys Asn 330335340345 GCT TGAGTTTATT CAAAGATAAC AAAGATGAAT GT 1097Ala (2) sequence 1012 data: (i) sequence characteristics: length (A): 346 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1012: met Lys Thr Tyr Asn Val Ala Ile Val Gly Ala Ser Gly Ala Val Gly 151015 Gln Glu Leu Ile Lys Gly Leu Glu Asn Ser Phe Phe Pro Ile Lys Lys
20 25 30Phe Val Pro Leu Ala Ser Thr Arg Sar Ala Gly Lys Lys Ile Lys Ala
35 40 45Phe Asn Lys Asp Tyr Clu Ile Leu Clu Thr Thr His Glu Val Phe Glu
50 55 60Arg Glu Lys Ile Asp Ile Ala Phe Phe Ser Ala Gly Gly Ser Val Ser65 70 75 80Xaa Glu Phe Ala Thr Ser Ala Ser Lys Thr Ala Leu Val Val Asp Asn
85 90 95Thr Ser Phe Phe Arg Leu Asn Lys Asp Val Pro Leu Val Val Pro Glu
100 105 110Ile Asn Ala Lys Glu Ile Phe Asn Ala Pro Leu Asn Ile Ile Ala Asn
115 120 125Pro Asn Cys Ser Thr Ile Gln Met Thr Gln Ile Leu Asn Pro Leu His
130 135 140Leu His Phe Lys Ile Lys Ser Val Ile Val Ser Thr Tyr Gln Ala Val145 150 155 160Ser Gly Ala Gly Asn Lys Gly Ile Glu Ser Leu Lys Asn Glu Leu Lys
165 170 175Thr Ala Leu Glu Cys Leu Glu Lys Asp Pro Thr Ile Asp Leu Asn Gln
180 185 190Val Leu Gln Ala Gly Ala Phe Ala Tyr Pro Ile Ala Phe Asn Ala Ile
195 200 205Ala His Ile Asp Thr Phe Lys Glu Asn Gly Tyr Thr Lys Glu Glu Leu
210 215 220Lys Met Leu His Glu Thr His Lys Ile Met Gly Val Asp Phe Pro Ile225 230 235 240Ser Ala Thr Cys Val Arg Val Pro Val Leu Arg Ser His Ser Glu Ser
245 250 255Leu Ser Ile Ala Phe Glu Lys Glu Phe Asp Leu Lys Glu Val Tyr Glu
260 265 270Val Leu Lys Asn Ala Pro Ser Val Ala Val Cys Asp Asp Pro SerHis
275 280 285Asn Leu Tyr Pro Thr Pro Leu Lys Ala Ser His Thr Asp Ser Val Phe
290 295 300Ile Gly Arg Leu Arg Lys Asp Leu Phe Asp Lys Lys Thr Leu His Gly305 310 315 320Phe Cys Val Ala Asp Gln Leu Arg Val Gly Ala Ala Thr Asn Ala Leu
325 330 335Lys lle Ala Leu His Tyr Ile Lys Asn Ala
340345 (2) sequence 1013 data: (i) sequence characteristics: length (A): 1395bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1359 (D) other information: (xi) Description of the sequence: sequence 1013: TAAAATTTTA GCATACAAAT ACAAGGAAAT GGA ATG ATT ACC CCT AAA GTG TTG 54
Met Ile Thr Pro Lys Val Leu
1 5 AGC GGG TTT AAA GAC CGC TTG CCT AAA GAT GCG ATA CAA AAA GCC CAG 102Ser Gly Phe Lys Asp Arg Leu Pro Lys Asp Ala Ile Gln Lys Ala Gln
10 15 20TTG CTT GCG AAA GTT TCA GTC GTG TTT CAA AGT TTT GGT TTT GTG CCG 150Leu Leu Ala Lys Val Ser Val Val Phe Gln Ser Phe Gly Phe Val Pro
25 30 35ATT GAA ACC CCT CAT TTG GAA TAC GCT CAA ACG TTA TTG CCT GAT GCG 198Ile Glu Thr Pro His Leu Glu Tyr Ala Gln Thr Leu Leu Pro Asp Ala40 45 50 55AGC AGT GAT ATT CAA AAA GAA ATT TAT CGT TTT AAA GAC CAT GGG GAT 246Ser Ser Asp Ile Gln Lys Glu Ile Tyr Arg Phe Lys Asp His Gly Asp
60 6570AGA GAT GTG GCT TTA AGG TTT GAT TTG ACT GTG CCA TTA GCC CGC TTT 294Arg Asp Val Ala Leu Arg Phe Asp Leu Thr Val Pro Leu Ala Arg Phe
75 80 85GTC TCT TTG CAC CAC CAA ACG CTA GGC ATG CCC TTT AAA CGC TAC GCT 342Val Ser Leu His His Gln Thr Leu Gly Met Pro Phe Lys Arg Tyr Ala
90 95 100ATA GGC AAT GTC TTT AGG GGC GAA AGG GCG CAA AAA GGG CGT TAT AGG 390Ile Gly Asn Val Phe Arg Gly Glu Arg Ala Gln Lys Gly Arg Tyr Arg
105 110 115GAA TTT ACG CAA TGC GAT TTT GAT TTT ATA GGG AGC GAG AGT TTG GTG 438Glu Phe Thr Gln Cys Asp Phe Asp Phe Ile Gly Ser Glu Ser Leu Val120 125 130 135TGC GAT GCT GAG ATC ATT CAA GTG ATT GTC GCT TCT TTA AAA GCC CTA 486Cys Asp Ala Glu Ile Ile Gln Val Ile Val Ala Ser Leu Lys Ala Leu
140 145 150GAT TTA GAA GAT TTT TGC GTC TCT ATC AAC CAC AGA AAA ATT TTG AAC 534Asp Leu Glu Asp Phe Cys Val Ser Ile Asn His Arg Lys Ile Leu Asn
155 160 165GGG ATA TGC GAA TAT TTT GGG ATC TCT CAA GTG AAT GAA GCG TTG CGC 582Gly Ile Cys Glu Tyr Phe Gly Ile Ser Gln Val Asn Glu Ala Leu Arg
170 175 180ATT GTG GAT AAA TTG GAA AAA ATT GGC TTG AAT GGG GTT GAA GAA GAA 630Ile Val Asp Lys Leu Glu Lys Ile Gly Leu Asn Gly Val Glu Glu Glu
185 190 195TTA AAA AAA GAG TGC GGT TTA AAT TCA AAC ACC ATT AAA GAG CTT TTA 678Leu Lys Lys Glu Cys Gly Leu Asn Ser Asn Thr Ile Lys Glu Leu Leu200 205 210 215GAA TTA ATT CAA ATC AAA CAA AAC GAT TTA AGC CAT GCG GAA TTT TTT 726Glu Leu Ile Gln Ile Lys Gln Asn Asp Leu Ser His Ala Glu Phe Phe
220 225 230GAA AAA ATT GCT TAT TTG AAA GAC TAT AAT GAA AAT CTA AAA AAA GGC 774Glu Lys Ile Ala Tyr Leu Lys Asp Tyr Asn Glu Asn Leu Lys Lys Gly
235 240 245ATA CAG GAT TTA GAA AGG CTA TAC CAG TTG CTA GGG GAT TTG CAA ATT 822Ile Gln Asp Leu Glu Arg Leu Tyr Gln Leu Leu Gly Asp Leu Gln Ile
250 255 260TCT CAA AAC CTG TAT AAA ATT GAT TTT TCT ATC GCT AGG GGA TTA GGG 870Ser Gln Asn Leu Tyr Lys Ile Asp Phe Ser Ile Ala Arg Gly Leu Gly
265 270 275TAT TAT ACA GGG ATT GTG TAT GAA ACC ACG CTT AAT GAA ATG AAG TCT 918Tyr Tyr Thr Gly Ile Val Tyr Glu Thr Thr Leu Asn Glu Met Lys Ser280 285 290 295TTA GGG AGC GTG TGT TCA GGG GGG CGT TAT GAT CAT TTG ACT AAA AAT 966Leu Gly Ser Val Cys Ser Gly Gly Arg Tyr Asp His Leu Thr Lys Asn
300 305 310TTT TCT AAA GAG AAT TTA CAA GGG GTA GGG GCT TCT ATT GGG ATT GAT 1014Phe Ser Lys Glu Asn Leu Gln Gly Val Gly Ala Ser Ile Gly Ile Asp
315 320 325CGA TTG ATT GTG GCT TTG AGT GAA ATG CAA TTA TTA GAC GAG CGC TCC 1062Arg Leu Ile Val Ala Leu Ser Glu Met Gln Leu Leu Asp Glu Arg Ser
330 335 340ACC CAA GCC AAA GTT TTA ATC GCT TGC ATG CAT GAA GAG TAT TTT TCT 1110Thr Gln Ala Lys Val Leu Ile Ala Cys Met His Glu Glu Tyr Phe Ser
345 350 355TAC GCC AAC CGC TTA GCG GAG TCT TTA AGG CAA AGC GGG ATT TTT AGT 1158Tyr Ala Asn Arg Leu Ala Glu Ser Leu Arg Gln Ser Gly Ile Phe Ser360 365 370 375GAA GTC TAT CCA GAA GCT CAA AAA ATC AAA AAA CCC TTT TCT TAT GCC 1206Glu Val Tyr Pro Glu Ala Gln Lys Ile Lys Lys Pro Phe Ser Tyr Ala
380 385 390AAC CAT AAA GGG CAT GAG TTT GTG GCT GTC ATT GGC GAA GAA GAA TTT 1254Asn His Lys Gly His Glu Phe Val Ala Val Ile Gly Glu Glu Glu Phe
395 400 405AAA AGC GAA ACT TTA AGC TTG AAA AAC ATG CAT TCA GGC ATG CAG TTG 1302Lys Ser Glu Thr Leu Ser Leu Lys Asn Met His Ser Gly Met Gln Leu
410 415 420AAT TGC TTG AGT TTT TTA AAA GCC CTT GAA ATC ATT GGA GAA AAC GAT 1350Asn Cys Leu Ser Phe Leu Lys Ala Leu Glu Ile Ile Gly Glu Asn Asp
425430435 GAA GAC TTA TAATGTCGCT ATTGTTGGGG CCAGTGGGGC GGTAGG 1395Glu Asp Leu440 (2) sequence 1014 data: (i) sequence characteristics: length (A): 442 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1014: met Ile Thr Pro Lys Val Leu Ser Gly Phe Lys Asp Arg Leu Pro Lys 151015 Asp Ala Ile Gln Lys Ala Gln Leu Leu Ala Lys Val Ser Val Val Phe
20 25 30Gln Ser Phe Gly Phe Val Pro Ile Glu Thr Pro His Leu Glu Tyr Ala
35 40 45Gln Thr Leu Leu Pro Asp Ala Ser Ser Asp Ile Gln Lys Glu Ile Tyr
50 55 60Arg Phe Lys Asp His Gly Asp Arg Asp Val Ala Leu Arg Phe Asp Leu65 70 75 80Thr Val Pro Leu Ala Arg Phe Val Ser Leu His His Gln Thr Leu Gly
85 90 95Met Pro Phe Lys Arg Tyr Ala Ile Gly Asn Val Phe Arg Gly Glu Arg
100 105 110Ala Gln Lys Gly Arg Tyr Arg Glu Phe Thr Gln Cys Asp Phe Asp Phe
115 120 125Ile Gly Ser Glu Ser Leu Val Cys Asp Ala Glu Ile Ile Gln Val Ile
130 135 140Val Ala Ser Leu Lys Ala Leu Asp Leu Glu Asp Phe Cys Val Ser Ile145 150 155 160Asn His Arg Lys Ile Leu Asn Gly Ile Cys Glu Tyr Phe Gly Ile Ser
165 170 175Gln Val Asn Glu Ala Leu Arg Ile Val Asp Lys Leu Glu Lys Ile Gly
180 185 190Leu Asn Gly Val Glu Glu Glu Leu Lys Lys Glu Cys Gly Leu Asn Ser
195 200 205Asn Thr Ile Lys Glu Leu Leu Glu Leu Ile Gln Ile Lys Gln Asn Asp
210 215 220Leu Ser His Ala Glu Phe Phe Glu Lys Ile Ala Tyr Leu Lys Asp Tyr225 230 235 240Asn Glu Asn Leu Lys Lys Gly Ile Gln Asp Leu Glu Arg Leu Tyr Gln
245 250 255Leu Leu Gly Asp Leu Gln Ile Ser Gln Asn Leu Tyr Lys Ile Asp Phe
260 265 270Ser Ile Ala Arg Gly Leu Gly Tyr Tyr Thr Gly Ile Val Tyr Glu Thr
275 280 285Thr Leu Asn Glu Met Lys Ser Leu Gly Ser Val Cys Ser Gly Gly Arg
290 295 300Tyr Asp His Leu Thr Lys Asn Phe Ser Lys Glu Asn Leu Gln Gly Val305 310 315 320Gly Ala Ser Ile Gly Ile Asp Arg Leu IleVal Ala Leu Ser Glu Met
325 330 335Gln Leu Leu Asp Glu Arg Ser Thr Gln Ala Lys Val Leu Ile Ala Cys
340 345 350Met His Glu Glu Tyr Phe Ser Tyr Ala Asn Arg Leu Ala Glu Ser Leu
355 360 365Arg Gln Ser Gly Ile Phe Ser Glu Val Tyr Pro Glu Ala Gln Lys Ile
370 375 380Lys Lys Pro Phe Ser Tyr Ala Asn His Lys Gly His Glu Phe Val Ala385 390 395 400Val Ile Gly Glu Glu Glu Phe Lys Ser Glu Thr Leu Ser Leu Lys Asn
405 410 415Met His Ser Gly Met Gln Leu Asn Cys Leu Ser Phe Leu Lys Ala Leu
420 425 430Glu Ile Ile Gly Glu Asn Asp Glu Asp Leu
435440 (2) data of SEQ ID No. 1015: (i) sequence characteristics: length (A): 639bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 597 (D) other information: (xi) Description of the sequence: sequence 1015: CACGCCCATA GGAGAAGTGG CAGAAGTTAT GCAGCTCTTA TTAAAGAAGG AAAAATTAAA 60GCTTGGGGG ATG AGT GAG GCA GGG TTA TCT AGC ATC CAA AAA GCC CAT CAA 111
Met Ser Glu Ala Gly Leu Ser Ser Ile Gln Lys Ala His Gln
1 5 10ATT TGC CCT TTA AGC GCG TTG CAG AGC GAA TAT TCC TTG TGG TGG CGC 159Ile Cys Pro Leu Ser Ala Leu Gln Ser Glu Tyr Ser Leu Trp Trp Arg15 20 25 30GAA CCT GAA AAA GAG ATT TTA GGT TTT TTA GAA AAA GAA AAA ATT GGA 207Glu Pro Glu Lys Glu IleLeu Gly Phe Leu Glu Lys Glu Lys Ile Gly
35 40 45TTT GTC GCT TTT TCG CCT TTG GGT AAG GGG TTT TTA GGC GCG AAA TTT 255Phe Val Ala Phe Ser Pro Leu Gly Lys Gly Phe Leu Gly Ala Lys Phe
50 55 60GAA AAA AAT GCC ACT TTC GCT AGT GAG GAT TTT AGA AGC GTT TCT CCT 303Glu Lys Asn Ala Thr Phe Ala Ser Glu Asp Phe Arg Ser Val Ser Pro
65 70 75AGG TTT AAT CAA GAA AAT CTA GCC AAA AAT TAC GCC TTG GTG GAA TTA 351Arg Phe Asn Gln Glu Asn Leu Ala Lys Asn Tyr Ala Leu Val Glu Leu
80 85 90ATC CAA GAT CAT GCA CAC GCT AAA GGC GTT ACA CCA GCC CAA CTG GCT 399Ile Gln Asp His Ala His Ala Lys Gly Val Thr Pro Ala Gln Leu Ala95 100 105 110CTC TCA TGG ATT TTG CAC ACG CAA AAA ATC ATT GTC CCT CTC TTT GGC 447Leu Ser Trp Ile Leu His Thr Gln Lys Ile Ile Val Pro Leu Phe Gly
115 120 125ACC ACC AAA GAA TCT AGG CTC ATA GAA AAT ATA GGG GCT TTG CAG GTT 495Thr Thr Lys Glu Ser Arg Leu Ile Glu Asn Ile Gly Ala Leu Gln Val
130 135 140TCT TGG AGT CAA AAA GAA TTG GAG ATT TTC CAA AAA GAA TTG ACT GCA 543Ser Trp Ser Gln Lys Glu Leu Glu Ile Phe Gln Lys Glu Leu Thr Ala
145 150 155ATC AAA ATA GAA GGG GCC CGC TAC CCT GAA AGA ATC AAT GAA ATG GTG 591Ile Lys Ile Glu Gly Ala Arg Tyr Pro Glu Arg Ile Asn Glu Met Val
160165170 AAT CAA TAAAAGTATT GGGTATTTAT AATTGCATTG GCTCTTTTAA AA 639Asn Gln175 (2) sequence 1016 data: (i) sequence characteristics: length (A): 176 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1016: met Ser Glu Ala Gly Leu Ser Ser Ile Gln Lys Ala His Gln Ile Cys 151015 Pro Leu Ser Ala Leu Gln Ser Glu Tyr Ser Leu Trp Trp Arg Glu Pro
20 25 30Glu Lys Glu Ile Leu Gly Phe Leu Glu Lys Glu Lys Ile Gly Phe Val
35 40 45Ala Phe Ser Pro Leu Gly Lys Gly Phe Leu Gly Ala Lys Phe Glu Lys
50 55 60Asn Ala Thr Phe Ala Ser Glu Asp Phe Arg Ser Val Ser Pro Arg Phe65 70 75 80Asn Gln Glu Asn Leu Ala Lys Asn Tyr Ala Leu ValGlu Leu Ile Gln
85 90 95Asp His Ala His Ala Lys Gly Val Thr Pro Ala Gln Leu Ala Leu Ser
100 105 110Trp Ile Leu His Thr Gln Lys Ile Ile Val Pro Leu Phe Gly Thr Thr
115 120 125Lys Glu Ser Arg Leu Ile Glu Asn Ile Gly Ala Leu Gln Val Ser Trp
130 135 140Ser Gln Lys Glu Leu Glu Ile Phe Gln Lys Glu Leu Thr Ala Ile Lys145 150 155 160Ile Glu Gly Ala Arg Tyr Pro Glu Arg Ile Asn Glu Met Val Asn Gln
165170175 (2) data of sequence 1017: (i) sequence characteristics: length (A): 2133bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 2088 (D) other information: (xi) Description of the sequence: sequence 1017: TAATTTAAAA AAGGAACATT AAAT ATG GAT TTT ATC ACC ATC AAT TCT AGT 51
Met Asp Phe Ile Thr Ile Asn Ser Ser
1 5AAC AAA ACC GAA GAG TTC GCT CTC AAA CAA GTG GCC AAA CAA GCC ACC 99Asn Lys Thr Glu Glu Phe Ala Leu Lys Gln Val Ala Lys Gln Ala Thr10 15 20 25AGC TCT CTT TTA TAC CGA TTA GGA AAA ACC ATT ATT TTA GCG AGC GTG 147Ser Ser Leu Leu Tyr Arg Leu Gly Lys Thr Ile Ile Leu Ala Ser Val
30 35 40TGC GTG GAA AGA GAG CCT GTG AGT GAA GAT TTT CTG CCT TTA GTG GTG 195Cys Val Glu Arg Glu Pro Val Ser Glu Asp Phe Leu Pro Leu Val Val
45 50 55CAG TTT TTA GAA AAA TCT TAT GCA GCC GGA AAG ATC CCG GGC GGT TTT 243Gln Phe Leu Glu Lys Ser Tyr Ala Ala Gly Lys Ile Pro Gly Gly Phe
60 65 70GTT AAA AGA GAA GGC AGG GCG CAA GAT TTT GAA ATC TTA ACC TCT AGG 291Val Lys Arg Glu Gly Arg Ala Gln Asp Phe Glu Ile Leu Thr Ser Arg
75 80 85CTC ATA GAC AGG ACT TTA CGC CCT TTA TTC CCT AAA GAC TAC CGC TAC 339Leu Ile Asp Arg Thr Leu Arg Pro Leu Phe Pro Lys Asp Tyr Arg Tyr90 95 100 105CCT ACA CAG ATC ACT TTA ATG GTT TTA AGC CAT GAT ATT GAA AAT GAC 387Pro Thr Gln Ile Thr Leu Met Val Leu Ser His Asp Ile Glu Asn Asp
110 115 120TTG CAG GTT TCT GCT TTA AAC GCC GCT TCA GCC GCT CTC TTT TTG GCC 435Leu Gln Val Ser Ala Leu Asn Ala Ala Ser Ala Ala Leu Phe Leu Ala
125 130 135CAT ATC GCT CCT ATT AAA AGC GTG AGC GCT TGC AGG ATC GCT AGG ATG 483His Ile Ala Pro Ile Lys Ser Val Ser Ala Cys Arg Ile Ala Arg Met
140145 150GAT AAC GAA TTT ATC ATT AAC CCT AGC GCA AGC CTT TTG AAT CAA TCC 531Asp Asn Glu Phe Ile Ile Asn Pro Ser Ala Ser Leu Leu Asn Gln Ser
155 160 165AGT TTG GAT TTG TTC GTG TCT GGA ACG AAA GAG AGT TTG AAC ATG ATA 579Ser Leu Asp Leu Phe Val Ser Gly Thr Lys Glu Ser Leu Asn Met Ile170 175 180 185GAA ATG CGC TCT TTG GGG CAA AAA TTG AAC GCT TTA GAA GAG CCT TTA 627Glu Met Arg Ser Leu Gly Gln Lys Leu Asn Ala Leu Glu Glu Pro Leu
190 195 200ATG TTA GAA GCT TTA GAA TTG GCT CAA AAA AGT TTG GAA GAA ACT TGC 675Met Leu Glu Ala Leu Glu Leu Ala Gln Lys Ser Leu Glu Glu Thr Cys
205 210 215ACG CTT TAT GAA GAG ATT TTC ACG CCC CAC CAA AAC GAG CTG TTT TTC 723Thr Leu Tyr Glu Glu Ile Phe Thr Pro His Gln Asn Glu Leu Phe Phe
220 225 230AAA GAG AGC CAA GGA ATA GTC TTT AAT GAA AGG CTG TTA GAT TTA TTG 771Lys Glu Ser Gln Gly Ile Val Phe Asn Glu Arg Leu Leu Asp Leu Leu
235 240 245AAA AAT CAG TAT TTT GAT GAA ATC ATC AAA GGC ATT GAA AGT TCT GCT 819Lys Asn Gln Tyr Phe Asp Glu Ile Ile Lys Gly Ile Glu Ser Ser Ala250 255 260 265TTG AGC GAG CGA GAA AAT GTT TTC AAT GAA ATT GCC AGA AAA ATC AGT 867Leu Ser Glu Arg Glu Asn Val Phe Asn Glu Ile Ala Arg Lys Ile Ser
270 275 280GAA GCC CAC TCA GAA TTC AGT TTA GAA GAA ATT GAA TTG TCT TTA GAA 915Glu Ala His Ser Glu Phe Ser Leu Glu Glu Ile Glu Leu Ser Leu Glu
285 290 295AAA GTG AAA AAG ACT GAG ATA AGA CGC ATG ATC ATT AAG GAT AAA ATC 963Lys Val Lys Lys Thr Glu Ile Arg Arg Met Ile Ile Lys Asp Lys Ile
300 305 310CGC CCG GAT AAG CGC GCG TTA GAA GAA GTG CGG CCC ATT TTG ATA GAG 1011Arg Pro Asp Lys Arg Ala Leu Glu Glu Val Arg Pro Ile Leu Ile Glu
315 320 325AGC GAT TTG CTC CCT ATG GCG CAT AGC TCC ATT TTA TTC ACT AGG GGG 1059Ser Asp Leu Leu Pro Met Ala His Ser Ser Ile Leu Phe Thr Arg Gly330 335 340 345CAA ACT CAA AGC TTA GTG GTA GGG GTT TTA GGC ACG GAT AAT GAC GCT 1107Gln Thr Gln Ser Leu Val Val Gly Val Leu Gly Thr Asp Asn Asp Ala
350 355 360CAA ACC CAT GAG AGT TTG GAG CAT AAA GCT CCC ATT AAA GAG CGC TTC 1155Gln Thr His Glu Ser Leu Glu His Lys Ala Pro Ile Lys Glu Arg Phe
365 370 375ATG TTT CAT TAT AAT TTC CCT CCT TTC TGC GTG GGC GAA GCG AGT TCT 1203Met Phe His Tyr Asn Phe Pro Pro Phe Cys Val Gly Glu Ala Ser Ser
380 385 390ATT GGC GCG GCT TCA AGG CGT GAA TTA GGG CAT GGG AAT TTG GCT AAA 1251Ile Gly Ala Ala Ser Arg Arg Glu Leu Gly His Gly Asn Leu Ala Lys
395 400 405AGA GCC TTA GAA ACG AGC ATT AAA AAT AAA GAG CAG GTG ATA CGA TTG 1299Arg Ala Leu Glu Thr Ser Ile Lys Asn Lys Glu Gln Val Ile Arg Leu410 415 420 425GTT TCT GAG ATT TTA GAA AGC AAT GGT TCA AGC TCA ATG GCG AGC GTG 1347Val Ser Glu Ile Leu Glu Ser Asn Gly Ser Ser Ser Met Ala Ser Val
430 435 440TGC GCA GGC TCT TTA GCC CTT TAT GCA AGC GGT GTG GAA ATT TAC GAT 1395Cys Ala Gly Ser Leu Ala Leu Tyr Ala Ser Gly Val Glu Ile Tyr Asp
445 450 455TTA GTC GCT GGG GTG GCT ATG GGC ATG GTG AGC GAA GGG CAA GAT CAC 1443Leu Val Ala Gly Val Ala Met Gly Met Val Ser Glu Gly Gln Asp His
460 465 470GCT ATT TTA AGC GAT ATT AGC GGC TTA GAA GAC GCA GAA GGC GAT ATG 1491Ala Ile Leu Ser Asp Ile Ser Gly Leu Glu Asp Ala Glu Gly Asp Met
475 480 485GAT TTT AAG ATT GCT GGG AAT TTA GAA GGC ATT ACG GCC ATG CAA ATG 1539Asp Phe Lys Ile Ala Gly Asn Leu Glu Gly Ile Thr Ala Met Gln Met490 495 500 505GAT ACC AAA ATG AGC GGT ATC AAG CTA GAA ATT TTA TAC CAA GCC TTA 1587Asp Thr Lys Met Ser Gly Ile Lys Leu Glu Ile Leu Tyr Gln Ala Leu
510 515 520CTC CAA GCC AAA GAA GCA CGG AAA CAT ATT TTA AAA ATC ATG CAT GAA 1635Leu Gln Ala Lys Glu Ala Arg Lys His Ile Leu Lys Ile Met His Glu
525 530 535GCG AAA GAA AAG ATT GTG ATC AAT TTT TCC CAT TTG CCC ACA ACG GAG 1683Ala Lys Glu Lys Ile Val Ile Asn Phe Ser His Leu Pro Thr Thr Glu
540 545 550ATT TTT AAT GTC GCA CCC GAT AAA ATT GTA GAA ATT ATC GGT CAA GGG 1731Ile Phe Asn Val Ala Pro Asp Lys Ile Val Glu Ile Ile Gly Gln Gly
555 560 565GGG CGT GTG ATT AAA GAG ATA GTA GAA AAG TTT GAA GTT AAA ATT GAT 1779Gly Arg Val Ile Lys Glu Ile Val Glu Lys Phe Glu Val Lys Ile Asp570 575 580 585TTG AAC AAA CCG AGC GGT GAA GTG AAA ATC ATG GGG AAT AAA GAG CGC 1827Leu Asn Lys Pro Ser Gly Glu Val Lys Ile Met Gly Asn Lys Glu Arg
590 595600GTT TTA AAG ACT AAG GAA TTT ATT TTA AAC TAC TTG CAT TCT TTA GAT 1875Val Leu Lys Thr Lys Glu Phe Ile Leu Asn Tyr Leu His Ser Leu Asp
605 610 615CAA GAA TTG GAG CAA TAC GCT ATT GAT GAG GTA TTA GAA GCT CAA GTG 1923Gln Glu Leu Glu Gln Tyr Ala Ile Asp Glu Val Leu Glu Ala Gln Val
620 625 630AAA CGA ATC GTG GAT TTT GGG GCG TTT TTA AGC TTG CCT AAG GGG GGC 1971Lys Arg Ile Val Asp Phe Gly Ala Phe Leu Ser Leu Pro Lys Gly Gly
635 640 645GAA GGC TTG TTA AGA AAG CAA AAC ATG GAC AAG TGT CAA GTG GTT TTA 2019Glu Gly Leu Leu Arg Lys Gln Asn Met Asp Lys Cys Gln Val Val Leu650 655 660 665AAA GAA GGC GAT AGC ATC AGG TGT AGG GTG ATT AGC TTC AAT AAG GGT 2067Lys Glu Gly Asp Ser Ile Arg Cys Arg Val Ile Ser Phe Asn Lys Gly
670 675 680AAA ATC GCT TTA GAT TTG GCT TAAAATTTTA AAAAGCGTTT TTTAAAAGCG TTTT 2122Lys Ile Ala Leu Asp Leu Ala
685TAAGCTAGTT T2133 (2) sequence 1018 data: (i) sequence characteristics: length (A): 688 amino acid (B) types: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1018: met Asp Phe Ile Thr Ile Asn Ser Ser Asn Lys Thr Glu Glu Phe Ala 151015 Leu Lys Gln Val Ala Lys Gln Ala Thr Ser Ser Leu Leu Tyr Arg Leu
20 25 30Gly Lys Thr Ile Ile Leu Ala Ser Val Cys Val Glu Arg Glu Pro Val
35 40 45Ser Glu Asp Phe Leu Pro Leu Val Val Gln Phe Leu Glu Lys Ser Tyr
50 55 60Ala Ala Gly Lys Ile Pro Gly Gly Phe Val Lys Arg GluGly Arg Ala65 70 75 80Gln Asp Phe Glu Ile Leu Thr Ser Arg Leu Ile Asp Arg Thr Leu Arg
85 90 95Pro Leu Phe Pro Lys Asp Tyr Arg Tyr Pro Thr Gln Ile Thr Leu Met
100 105 110Val Leu Ser His Asp Ile Glu Asn Asp Leu Gln Val Ser Ala Leu Asn
115 120 125Ala Ala Ser Ala Ala Leu Phe Leu Ala His Ile Ala Pro Ile Lys Ser
130 135 140Val Ser Ala Cys Arg Ile Ala Arg Met Asp Asn Glu Phe Ile Ile Asn145 150 155 160Pro Ser Ala Ser Leu Leu Asn Gln Ser Ser Leu Asp Leu Phe Val Ser
165 170 175Gly Thr Lys Glu Ser Leu Asn Met Ile Glu Met Arg Ser Leu Gly Gln
180 185 190Lys Leu Asn Ala Leu Glu Glu Pro Leu Met Leu Glu Ala Leu Glu Leu
195 200 205Ala Gln Lys Ser Leu Glu Glu Thr Cys Thr Leu Tyr Glu Glu Ile Phe
210 215 220Thr Pro His Gln Asn Glu Leu Phe Phe Lys Glu Ser Gln Gly Ile Val225 230 235 240Phe Asn Glu Arg Leu Leu Asp Leu Leu Lys Asn Gln Tyr Phe Asp Glu
245 250 255Ile Ile Lys Gly Ile Glu Ser Ser Ala Leu Ser Glu Arg Glu Asn Val
260 265 270Phe Asn Glu Ile Ala Arg Lys Ile Ser Glu Ala His Ser Glu Phe Ser
275 280 285Leu Glu Glu Ile Glu Leu Ser Leu Glu Lys Val Lys Lys Thr Glu Ile
290 295 300Arg Arg Met Ile Ile Lys Asp Lys Ile Arg Pro Asp Lys Arg Ala Leu305 310 315 320Glu Glu Val Arg Pro Ile Leu Ile Glu Ser Asp Leu Leu Pro Met Ala
325 330 335His Ser Ser Ile Leu Phe Thr Arg Gly Gln Thr Gln Ser Leu Val Val
340 345 350Gly Val Leu Gly Thr Asp Asn Asp Ala Gln Thr His Glu Ser Leu Glu
355 360 365His Lys Ala Pro Ile Lys Glu Arg Phe Met Phe His Tyr Asn Phe Pro
370 375 380Pro Phe Cys Val Gly Glu Ala Ser Ser Ile Gly Ala Ala Ser Arg Arg385 390 395 400Glu Leu Gly His Gly Asn Leu Ala Lys Arg Ala Leu Glu Thr Ser Ile
405 410 415Lys Asn Lys Glu Gln Val Ile Arg Leu Val Ser Glu Ile Leu Glu Ser
420 425 430Asn Gly Ser Ser Ser Met Ala Ser Val Cys Ala Gly Ser Leu Ala Leu
435 440 445Tyr Ala Ser Gly Val Glu Ile Tyr Asp Leu Val Ala Gly Val Ala Met
450 455 460Gly Met Val Ser Glu Gly Gln Asp Hls Ala Ile Leu Ser Asp Ile Ser465 470 475 480Gly Leu Glu Asp Ala Glu Gly Asp Met Asp Phe Lys Ile Ala Gly Asn
485 490 495Leu Glu Gly Ile Thr Ala Met Gln Met Asp Thr Lys Met Ser Gly Ile
500 505 510Lys Leu Glu Ile Leu Tyr Gln Ala Leu Leu Gln Ala Lys Glu AlaArg
515 520 525Lys His Ile Leu Lys Ile Met His Glu Ala Lys Glu Lys Ile Val Ile
530 535 540Asn Phe Ser His Leu Pro Thr Thr Glu Ile Phe Asn Val Ma Pro Asp545 550 555 560Lys Ile Val Glu Ile Ile Gly Gln Gly Gly Arg Val Ile Lys Glu Ile
565 570 575Val Glu Lys Phe Glu Val Lys Ile Asp Leu Asn Lys Pro Ser Gly Glu
580 585 590Val Lys Ile Met Gly Asn Lys Glu Arg Val Leu Lys Thr Lys Glu Phe
595 600 605Ile Leu Asn Tyr Leu His Ser Leu Asp Gln Glu Leu Glu Gln Tyr Ala
610 615 620Ile Asp Glu Val Leu Glu Ala Gln Val Lys Arg Ile Val Asp Phe Gly625 630 635 640Ala Phe Leu Ser Leu Pro Lys Gly Gly Glu Gly Leu Leu Arg Lys Gln
645 650 655Asn Met Asp Lys Cys Gln Val Val Leu Lys Glu Gly Asp Ser Ile Arg
660 665 670Cys Arg Val Ile Ser Phe Asn Lys Gly Lys Ile Ala Leu Asp Leu Ala
675680685 (2) SEQ ID NO: (i) sequence characteristics: length (A): 1340bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1296 (D) other information: (xi) Description of the sequence: sequence 1019: AAACAACCAC ATTGCAGGAA AGAC ATG AAA GAT AAC AAT AAC TAT AAT GTT 51
Met Lys Asp Asn Asn Asn Tyr Asn Val
1 5TTA ATT GTG GGG AAT AAG GGG CGA GAG TAT GCT TTG GCT CAA AGG CTT 99Leu Ile Val Gly Asn Lys Gly Arg Glu Tyr Ala Leu Ala Gln Arg Leu10 15 20 25CAG CAA GAT GAG CGA GTG AAT GCT TTG TAT TTT TGT TTG GGT AAT GGT 147Gln Gln Asp Glu Arg Val Asn Ala Leu Tyr Phe Cys Leu Gly Asn Gly
30 35 40GGC ACT CAA GAT TTA GGC GAG AAT CTG GAA TGC GAA CAT TAC GAG CAT 195Gly Thr Gln Asp Leu Gly Glu Asn Leu Glu Cys Glu His Tyr Glu His
45 50 55ATC GTG GAA TTA GCC CTG AAA AAA CAG ATC CAT TTA GCC ATC ATT TCA 243Ile Val Glu Leu Ala Leu Lys Lys Gln Ile His Leu Ala Ile Ile Ser
60 65 70GAA GAA GAG TTT TTG GTT TTA GGG CTT ACA GAA ATG CTA GAA AAA GCG 291Glu Glu Glu Phe Leu Val Leu Gly Leu Thr Glu Met Leu Glu Lys Ala
75 80 85GGG ATT TTA GTG TTT GGG GCT TCT AAA GAA GCG GCT AAG TTA GAG GCT 339Gly Ile Leu Val Phe Gly Ala Ser Lys Glu Ala Ala Lys Leu Glu Ala90 95 100 105TCT AAA AGC TAT ATG AAA GCT TTT GTT AAA GAG TGT GGC ATC AAA AGT 387Ser Lys Ser Tyr Met Lys Ala Phe Val Lys Glu Cys Gly Ile Lys Ser
110 115 120GCG TCT TAC TTT GAA ACA AAC GAC TTA AAA GAA GCT TTG AGT TAC ATT 435Ala Ser Tyr Phe Glu Thr Asn Asp Leu Lys Glu Ala Leu Ser Tyr Ile
125 130 135CAA AAC GCT TCT TTC CCC TTA GTC ATT AAA GCG TTG AAT AAA AAC ACA 483Gln Asn Ala Ser Phe Pro Leu Val Ile Lys Ala Leu Asn Lys Asn Thr
140 145 150AGC ATT GTC TAT CAA GAA GAA GAA GCG ATA AAA ATC CTT GAA GAC GCT 531Ser Ile Val Tyr Gln Glu Glu Glu Ala Ile Lys Ile Leu Glu Asp Ala
155 160 165TTC AAA CAA AGC AAT GAG CCT GTG ATT ATA GAG CCT TTT TTA GAG GGA 579Phe Lys Gln Ser Asn Glu Pro Val Ile Ile Glu Pro Phe Leu Glu Gly170 175 180 185TTT GAG CTT TCA GTT ACA GCG CTC ATA GCC AAT GAT GAT TTT ATC TTG 627Phe Glu Leu Ser Val Thr Ala Leu Ile Ala Asn Asp Asp Phe Ile Leu
190 195 200TTG CCC TTT TGC CAA AAC TAC AAA CGC TTA TTA GAG GGG GAT AAT GGG 675Leu Pro Phe Cys Gln Asn Tyr Lys Arg Leu Leu Glu Gly Asp Asn Gly
205 210 215GTC AAT ACG GGG GGT ATG GGG GCC ATC GCT CCT GCA AAC TTT TTC TCT 723Val Asn Thr Gly Gly Met Gly Ala Ile Ala Pro Ala Asn Phe Phe Ser
220 225 230AAT GAA TTA GAA GAG AAA ATA AAA AAT CAT ATC TTT AAA CCC ACT TTA 771Asn Glu Leu Glu Glu Lys Ile Lys Asn His Ile Phe Lys Pro Thr Leu
235 240 245GAG AAA CTT CAG GCT GAC AAC ACG CCT TTT AAA GGG GTT TTA CTC GCT 819Glu Lys Leu Gln Ala Asp Asn Thr Pro Phe Lys Gly Val Leu Leu Ala250 255 260 265GAA ATT GTA ATC ATA GAA GAA AAA GGC GTT TTA GAG CCG TAT TTA TTG 867Glu Ile Val Ile Ile Glu Glu Lys Gly Val Leu Glu Pro Tyr Leu Leu
270 275 280GAT TTT AGC GTG CGT TTT AAA GAC ATT GAA TGC CAG ACG ATT TTA CCC 915Asp Phe Ser Val Arg Phe Lys Asp Ile Glu Cys Gln Thr Ile Leu Pro
285 290 295CTT TTA GAA AGC TCG CTT TTA GAT TTG TGT TTG GCC ACA GCC AAA GGG 963Leu Leu Glu Ser Ser Leu Leu Asp Leu Cys Leu Ala Thr Ala Lys Gly
300 305 310GAA TTA CAT TCT CTT GAA TTG GTG TTT TCT AAA GAA TTT GTG ATG AGT 1011Glu Leu His Ser Leu Glu Leu Val Phe Ser Lys Glu Phe Val Met Ser
315 320 325GTG GCG CTT GTT TCT AGG AAT TAC CCC ACT AGC TCT TCG CCC AAA CAA 1059Val Ala Leu Val Ser Arg Asn Tyr Pro Thr Ser Ser Ser Pro Lys Gln330 335 340 345ACC CTT TAT ATT GAT CCG GTT GAT GAA AAA AAG GGT CAT TTG ATT TTA 1107Thr Leu Tyr Ile Asp Pro Val Asp Glu Lys Lys Gly His Leu Ile Leu
350 355 360GGG GAG GTG GAG CAG GAT AAT GGC GTG TTT GAA AGC AGT GGG GGG AGG 1155Gly Glu Val Glu Gln Asp Asn Gly Val Phe Glu Ser Ser Gly Gly Arg
365 370 375GTG ATC TTT GCC ATT GGT AGG GGA AAA TCC TTA TTA GAA GCC AGA AAC 1203Val Ile Phe Ala Ile Gly Arg Gly Lys Ser Leu Leu Glu Ala Arg Asn
380 385 390CAT GCT TAT GAA ATC GCT CAA AAG GTG CAT TTT GAA GGC ATG TTT TAT 1251His Ala Tyr Glu Ile Ala Gln Lys Val His Phe Glu Gly Met Phe Tyr
395400405 CGC AAG GAT ATT GGT TTT AAG GTG TTA GAT TTG AAA GAA TAT TCT TAAAG 1301Arg Lys Asp Ile Gly Phe Lys Val Leu Asp Leu Lys Glu Tyr Ser 410415420 GTTAAAGTTT AAGACAAACC AAAGAGTTTG TCTTGTTTG 1340 (2) sequence 1020 data: (i) sequence characteristics: length (A): 424 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1020: met Lys Asp Asn Asn Asn Tyr Asn Val Leu Ile Val Gly Asn Lys Gly 151015 Arg Glu Tyr Ala Leu Ala Gln Arg Leu Gln Gln Asp Glu Arg Val Asn
20 25 30Ala Leu Tyr Phe Cys Leu Gly Asn Gly Gly Thr Gln Asp Leu Gly Glu
35 40 45Asn Leu Glu Cys Glu His Tyr Glu His Ile Val Glu Leu Ala Leu Lys
50 55 60Lys Gln Ile His Leu Ala Ile Ile Ser Glu Glu Glu Phe Leu Val Leu65 70 75 80Gly Leu Thr Glu Met Leu Glu Lys Ala Gly Ile Leu Val Phe Gly Ala
85 90 95Ser Lys Glu Ala Ala Lys Leu Glu Ala Ser Lys Ser Tyr Met Lys Ala
100 105 110Phe Val Lys Glu Cys Gly Ile Lys Ser Ala Ser Tyr Phe Glu Thr Asn
115 120 125Asp Leu Lys Glu Ala Leu Ser Tyr Ile Gln Asn Ala Ser Phe Pro Leu
130 135 140Val Ile Lys Ala Leu Asn Lys Asn Thr Ser Ile Val Tyr Gln Glu Glu145 150 155 160Glu Ala Ile Lys Ile Leu Glu Asp Ala Phe Lys Gln Ser Asn Glu Pro
165 170 175Val Ile Ile Glu Pro Phe Leu Glu Gly Phe Glu Leu Ser Val Thr Ala
180 185 190Leu Ile Ala Asn Asp Asp Phe Ile Leu Leu Pro Phe Cys Gln Asn Tyr
195 200 205Lys Arg Leu Leu Glu Gly Asp Asn Gly Val Asn Thr Gly Gly Met Gly
210 215 220Ala Ile Ala Pro Ala Asn Phe Phe Ser Asn Glu Leu Glu Glu Lys Ile225 230 235 240Lys Asn His Ile Phe Lys Pro Thr Leu Glu Lys Leu Gln Ala Asp Asn
245 250 255Thr Pro Phe Lys Gly Val Leu Leu Ala Glu Ile Val Ile Ile Glu Glu
260 265 270Lys Gly Val Leu Glu Pro Tyr Leu Leu Asp Phe Ser Val Arg Phe Lys
275 280 285Asp Ile Glu Cys Gln Thr Ile Leu Pro Leu Leu Glu Ser Ser Leu Leu
290 295 300Asp Leu Cys Leu Ala Thr Ala Lys Gly Glu Leu His Ser Leu Glu Leu305 310 315 320Val Phe Ser Lys Glu Phe Val Met Ser Val Ala Leu Val Ser Arg Asn
325 330 335Tyr Pro Thr Ser Ser Ser Pro Lys Gln Thr Leu Tyr Ile Asp Pro Val
340 345 350Asp Glu Lys Lys Gly His Leu Ile Leu Gly Glu Val Glu Gln Asp Asn
355 360 365Gly Val Phe Glu Ser Ser Gly Gly Arg Val Ile Phe Ala Ile Gly Arg
370 375 380Gly Lys Ser Leu Leu Glu Ala Arg Asn His Ala Tyr Glu Ile Ala Gln385 390 395 400Lys Val His Phe Glu Gly Met Phe Tyr Arg Lys Asp Ile Gly Phe Lys
405 410 415Val Leu Asp Leu Lys Glu Tyr Ser
420 (2) sequence 1021 data: (i) sequence characteristics: length (A): 827bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 769 (D) other information: (xi) Description of the sequence: sequence 1021: TTAAAATGAA GTGAAA ATG AGA GAA ATA AAT ATG ATT TTA TAC ATT CAT ATC 52
Met Arg Glu Ile Asn Met Ile Leu Tyr Ile His Ile
1 5 10CCC TTT TGT GAA AAT AAA TGC GGC TAT TGC GCT TTC AAT TCC TAT GAA 100Pro Phe Cys Glu Asn Lys Cys Gly Tyr Cys Ala Phe Asn Ser Tyr Glu
15 20 25AAC AAG CAT GGG TTA AAA GAA GAA TAC ACT CAA GCG TTA TGC CTG GAT 148Asn Lys His Gly Leu Lys Glu Glu Tyr Thr Gln Ala Leu Cys Leu Asp
30 35 40TTA AAG CAT GCG TTA AGT CAA ACT GAC GAA CCA ATT GAA AGC GTT TTT 196Leu Lys His Ala Leu Ser Gln Thr Asp Glu Pro Ile Glu Ser Val Phe45 50 55 60ATT GGT GGC GGC ACG CCT AAC ACT TTA AGC GTG AAG GCT TTT GAA AGG 244Ile Gly Gly Gly Thr Pro Asn Thr Leu Ser Val Lys Ala Phe Glu Arg
65 70 75ATT TTT GAA AGC ATT TAT CAA CAT GCG AGC TTG AGC TTG GAT TGT GAG 292Ile Phe Glu Ser Ile Tyr Gln His Ala Ser Leu Ser Leu Asp Cys Glu
80 85 90ATC ACC ACT GAA GCT AAC CCC GAA TTG ATT ACT AAA GCT TGG TGT CAA 340Ile Thr Thr Glu Ala Asn Pro Glu Leu Ile Thr Lys Ala Trp Cys Gln
95 100 105GGC TTA AAA GGT TTA GGG ATC AAC CGC TTG AGT TTA GGG GTG CAA AGT 388Gly Leu Lys Gly Leu Gly Ile Asn Arg Leu Ser Leu Gly Val Gln Ser
110 115 120TTT AGG GAA GAT AAA TTA TTG TTT TTA GAG CGC CAA CAT TCC AAA AAT 436Phe Arg Glu Asp Lys Leu Leu Phe Leu Glu Arg Gln His Ser Lys Asn125 130 135 140ATC GCT CCT GCG ATA GAA ACT ATT TTA AAA AGC GGG ATT GAA AAT ATC 484Ile Ala Pro Ala Ile Glu Thr Ile Leu Lys Ser Gly Ile Glu Asn Ile
145 150 155AGC ATT GAT TTG ATT TAT AAC ACC CCA TTAGAC AAT GAA AAC TCT CTA 532Ser Ile Asp Leu Ile Tyr Asn Thr Pro Leu Asp Asn Glu Asn Ser Leu
160 165 170AAA GAA GAA TTA AAA CTC GCT AAA GAA CTC CCT ATC AAC CAC TTG AGC 580Lys Glu Glu Leu Lys Leu Ala Lys Glu Leu Pro Ile Asn His Leu Ser
175 180 185GCT TAC GCT TTG AGC GTT GAA AAA AAC ACG AAT TTA GAA AAA AAC GCC 628Ala Tyr Ala Leu Ser Val Glu Lys Asn Thr Asn Leu Glu Lys Asn Ala
190 195 200AAA AAA CCC TCA TGC GCT CAT TTT GAC AAT GTG GTG AGA GAG ATT TTA 676Lys Lys Pro Ser Cys Ala His Phe Asp Asn Val Val Arg Glu Ile Leu205 210 215 220GAG GGC TTT TCT TTC AAG CAA TAC GAG TGT CTA ATT ACG CTA GAA ATT 724Glu Gly Phe Ser Phe Lys Gln Tyr Glu Cys Leu Ile Thr Leu Glu Ile
225 230 235ATC AAG TCA AAC ACA ACT TGG CTT ACT GGG GGG CTA AAG ATT ATT TAGGG 774Ile Lys Ser Asn Thr Thr Trp Leu Thr Gly Gly Leu Lys Ile Ile
240245250 TGCGGGGCTG GGGCTGTGGG CTGCGTGGCG AATGAGCGCT TTTTTGCAAA AAA 827 (827) (2) data sequence 1022: (i) sequence characteristics: length (A): 251 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1022Met Arg Glu Ile Asn Met Ile Leu Tyr Ile His Ile Pro Phe Cys Glu 151015 Asn Lys Cys Gly Tyr Cys Ala Phe Asn Ser Tyr Glu Asn Lys His Gly
20 25 30Leu Lys Glu Glu Tyr Thr Gln Ala Leu Cys Leu Asp Leu Lys His Ala
35 40 45Leu Ser Gln Thr Asp Glu Pro Ile Glu Ser Val Phe Ile Gly Gly Gly
50 55 60Thr Pro Asn Thr Leu Ser Val Lys Ala Phe Glu Arg Ile Phe Glu Ser65 70 75 80Ile Tyr Gln His Ala Ser Leu Ser Leu Asp Cys Glu Ile Thr Thr Glu
85 90 95Ala Asn Pro Glu Leu Ile Thr Lys Ala Trp Cys Gln Gly Leu Lys Gly
100 105 110Leu Gly Ile Asn Arg Leu Ser Leu Gly Val Gln Ser Phe Arg Glu Asp
115 120 125Lys Leu Leu Phe Leu Glu Arg Gln His Ser Lys Asn Ile Ala Pro Ala
130 135 140Ile Glu Thr Ile Leu Lys Ser Gly Ile Glu Asn Ile Ser Ile Asp Leu145 150 155 160Ile Tyr Asn Thr Pro Leu Asp Asn Glu Asn Ser Leu Lys Glu Glu Leu
165 170 175Lys Leu Ala Lys Glu Leu Pro Ile Asn His Leu Ser Ala Tyr Ala Leu
180 185 190Ser Val Glu Lys Asn Thr Asn Leu Glu Lys Asn Ala Lys Lys Pro Ser
195 200 205Cys Ala His Phe Asp Asn Val Val Arg Glu Ile Leu Glu Gly Phe Ser
210 215 220Phe Lys Gln Tyr Glu Cys Leu Ile Thr Leu Glu Ile Ile Lys Ser Asn225 230 235 240Thr Thr Trp Leu Thr Gly Gly Leu Lys Ile Ile
245620 (2) sequence 1023 data: (i) sequence characteristics: length (A): 1291bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 76...1257 (D) other information: (xi) Description of the sequence: sequence 1023: GCCAAGTCAT TGCTTATTTC AAAAGAGAGG GGTATTTATA GGGTGTTAAT CGTTCAAAAA 60TACGGCGGCA CGAGC ATG GGC AGC ATA GAA AGG ATC CAC AAT GTC GCT CAA 111
Met Gly Ser Ile Glu Arg Ile His Asn Val Ala Gln
1 5 10AGG GTT TTA GAA AGC GTT ACA TTA GGG CAT CAA GTC GTG GTG GTG GTT 159Arg Val Leu Glu Ser Val Thr Leu Gly His Gln Val Val Val Val Val
15 20 25TCA GCG ATG AGC GGC GAA ACC GAC AGG CTT TTA GAA TTT GGC AAG AAT 207Ser Ala Met Ser Gly Glu Thr Asp Arg Leu Leu Glu Phe Gly Lys Asn
30 35 40TTT AGC CAT AAC CCT AAC AAG CGA GAG ATG GAC AGG ATT GTA AGC GTG 255Phe Ser His Asn Pro Asn Lys Arg Glu Met Asp Arg Ile Val Ser Val45 50 55 60GGG GAA TTG GTT TCA AGT GCG GCT TTG AGC ATG GCG TTA GAA AGG TAT 303Gly Glu Leu Val Ser Ser Ala Ala Leu Ser Met Ala Leu Glu Arg Tyr
65 70 75GGG CAT AGA GCC ATT TCC TTG AGC GGG AAA GAA GCG GGC ATT TTA ACC 351Gly His Arg Ala Ile Ser Leu Ser Gly Lys Glu Ala Gly Ile Leu Thr
80 85 90AGC TCG CAT TTT CAA AAC GCC GTG ATC CAA TCC ATT GAC ACC AAA CGC 399Ser Ser His Phe Gln Asn Ala Val Ile Gln Ser Ile Asp Thr Lys Arg
95 100 105ATC ACA GAG CTT TTA GAA AAA AAC TAC ATT GTG GTG ATC GCT GGG TTT 447Ile Thr Glu Leu Leu Glu Lys Asn Tyr Ile Val Val Ile Ala Gly Phe
110 115 120CAA GGC GCT GAT ATT CAA GGT GAA ACA ACG ACT TTA GGG CGT GGG GGG 495Gln Gly Ala Asp Ile Gln Gly Glu Thr Thr Thr Leu Gly Arg Gly Gly125 130 135 140AGC GAT TTG AGC GCG GTT GCT TTG GCC GGG GCT TTA AAA GCG CAT TTG 543Ser Asp Leu Ser Ala Val Ala Leu Ala Gly Ala Leu Lys Ala His Leu
145 150 155TGC GAA ATC TAT ACG GAT GTG GAT GGC GTT TAT ACC ACC GAT CCG CGC 591Cys Glu Ile Tyr Thr Asp Val Asp Gly Val Tyr Thr Thr Asp Pro Arg
160 165 170ATT GAA GAA AAG GCT CAA AAA ATC GCG CAA ATC AGC TAT GAT GAA ATG 639Ile Glu Glu Lys Ala Gln Lys Ile Ala Gln Ile Ser Tyr Asp Glu Met
175 180 185CTT GAA CTG GCT TCT ATG GGG GCT AAA GTT TTA TTA AAC CGC TCG GTG 687Leu Glu Leu Ala Ser Met Gly Ala Lys Val Leu Leu Asn Arg Ser Val
190 195 200GAA TTA GCC AAA AAG CTC AGC GTG AAG TTA GTG ACT CGC AAT TCG TTT 735Glu Leu Ala Lys Lys Leu Ser Val Lys Leu Val Thr Arg Asn Ser Phe205 210 215 220AAC CAT AGC GAA GGC ACG CTC ATT GTG GCT GAA AAA GAC TTT AAA GGA 783Asn His Ser Glu Gly Thr Leu Ile Val Ala Glu Lys Asp Phe Lys Gly
225 230 235GAA CGC ATG GAA ACC CCT ATA GTG AGT GGG ATC GCA TTG GAT AAA AAT 831Glu Arg Met Glu Thr Pro Ile Val Ser Gly Ile Ala Leu Asp Lys Asn
240 245 250CAG GCT CGT GTG AGC ATG GAG GGC GTG GAA GAT CGG CCA GGC ATT GCC 879Gln Ala Arg Val Ser Met Glu Gly Val Glu Asp Arg Pro Gly Ile Ala
255 260 265GCT GAA ATC TTT GGC GCT TTA GCG GAG TAT CGC ATT AAC GTG GAT ATG 927Ala Glu Ile Phe Gly Ala Leu Ala Glu Tyr Arg Ile Asn Val Asp Met
270 275 280ATC GTC CAA ACG ATC GGC AGA GAC GGC AAA ACC GAT TTG GAT TTT ACG 975Ile Val Gln Thr Ile Gly Arg AspGly Lys Thr Asp Leu Asp Phe Thr285 290 295 300ATC GTT AAA ACC CAA ATA GAA GAA ACC AAG CAA GCC TTA AAG CCT TTT 1023Ile Val Lys Thr Gln Ile Glu Glu Thr Lys Gln Ala Leu Lys Pro Phe
305 310 315TTA GCG CAA ATG GAT TCC ATT GAT TAT GAT GAA AAT ATC GCT AAA GTC 1071Leu Ala Gln Met Asp Ser Ile Asp Tyr Asp Glu Asn Ile Ala Lys Val
320 325 330TCC ATA GTG GGC GTG GGC ATG AAG TCG CAT TCT GGG GTG GCG AGT ATC 1119Ser Ile Val Gly Val Gly Met Lys Ser His Ser Gly Val Ala Ser Ile
335 340 345GCT TTT AAA GCC CTA GCC AAA GAC AAT ATC AAT ATC ATG ATG ATT TCT 1167Ala Phe Lys Ala Leu Ala Lys Asp Asn Ile Asn Ile Met Met Ile Ser
350 355 360ACA AGC GAG ATT AAA ATT TCG GTT TTG ATT GAC ATT AAA TAC GCT GAA 1215Thr Ser Glu Ile Lys Ile Ser Val Leu Ile Asp Ile Lys Tyr Ala Glu365 370 375 380TTA GCT GTT AGA ACT TTG CAT GCG GTG TAT CAA TTA GAT CAA TGAAAAATT 1266Leu Ala Val Arg Thr Leu His Ala Val Tyr Gln Leu Asp Gln
385390 TCTACGATTG GATCAAGGAA TTTGT 1291 (2) sequence 1024 data: (i) sequence characteristics: length (A): 394 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1024: met Gly Ser Ile Glu Arg Ile His Asn Val Ala Gln Arg Val Leu Glu 151015 Ser Val Thr Leu Gly His Gln Val Val Val Val Val Ser Ala Met Ser
20 25 30Gly Glu Thr Asp Arg Leu Leu Glu Phe Gly Lys Asn Phe Ser His Asn
35 40 45Pro Asn Lys Arg Glu Met Asp Arg Ile Val Ser Val Gly GluLeu Val
50 55 60Ser Ser Ala Ala Leu Ser Met Ala Leu Glu Arg Tyr Gly His Arg Ala65 70 75 80Ile Ser Leu Ser Gly Lys Glu Ala Gly Ile Leu Thr Ser Ser His Phe
85 90 95Gln Asn Ala Val Ile Gln Ser Ile Asp Thr Lys Arg Ile Thr Glu Leu
100 105 110Leu Glu Lys Asn Tyr Ile Val Val Ile Ala Gly Phe Gln Gly Ala Asp
115 120 125Ile Gln Gly Glu Thr Thr Thr Leu Gly Arg Gly Gly Ser Asp Leu Ser
130 135 140Ala Val Ala Leu Ala Gly Ala Leu Lys Ala His Leu Cys Glu Ile Tyr145 150 155 160Thr Asp Val Asp Gly Val Tyr Thr Thr Asp Pro Arg Ile Glu Glu Lys
165 170 175Ala Gln Lys Ile Ala Gln Ile Ser Tyr Asp Glu Met Leu Glu Leu Ala
180 185 190Ser Met Gly Ala Lys Val Leu Leu Asn Arg Ser Val Glu Leu Ala Lys
195 200 205Lys Leu Ser Val Lys Leu Val Thr Arg Asn Ser Phe Asn His Ser Glu
210 215 220Gly Thr Leu Ile Val Ala Glu Lys Asp Phe Lys Gly Glu Arg Met Glu225 230 235 240Thr Pro Ile Val Ser Gly Ile Ala Leu Asp Lys Asn Gln Ala Arg Val
245 250 255Ser Met Glu Gly Val Glu Asp Arg Pro Gly Ile Ala Ala Glu Ile Phe
260 265 270Gly Ala Leu Ala Glu Tyr Arg Ile Asn Val AspMet Ile Val Gln Thr
275 280 285Ile Gly Arg Asp Gly Lys Thr Asp Leu Asp Phe Thr Ile Val Lys Thr
290 295 300Gln Ile Glu Glu Thr Lys Gln Ala Leu Lys Pro Phe Leu Ala Gln Met305 310 315 320Asp Ser Ile Asp Tyr Asp Glu Asn Ile Ala Lys Val Ser Ile Val Gly
325 330 335Val Gly Met Lys Ser His Ser Gly Val Ala Ser Ile Ala Phe Lys Ala
340 345 350Leu Ala Lys Asp Asn Ile Asn Ile Met Met Ile Ser Thr Ser Glu Ile
355 360 365Lys Ile Ser Val Leu Ile Asp Ile Lys Tyr Ala Glu Leu Ala Val Arg
370375380 Thr Leu His Ala Val Tyr Gln Leu Asp Gln 385390 (2) sequence 1025 data: (i) sequence characteristics: length (A): 706bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 663 (D) other information: (xi) Description of the sequence: sequence 1025: GGT TAC TCT GTG AAA AAC TCC AAC CGC CTT ATT TAT ACG GAC AAT CTT 48Gly Tyr Ser Val Lys Asn Ser Asn Arg Leu Ile Tyr Thr Asp Asn Leu 151015 GAA GAG AGC CTA GAA GAG ACT GCA AGC CTT TTT GAA CAC CAC ATT AAA 96Glu Glu Ser Leu Glu Glu Thr Ala Ser Leu Phe Glu His His Ile Lys
20 25 30TTC TAC ACG GAG ATT ATT GAA AAA GAC AAA AAG GTG ATC AAA ACT TTC 144Phe Tyr Thr Glu Ile Ile Glu Lys Asp Lys Lys Val Ile Lys Thr Phe
35 40 45AAC AAG GAT TTT AAA ATA GAG CAT GCC AAA GAA GTC ATT TCC AAA GCT 192Asn Lys Asp Phe Lys Ile Glu His Ala Lys Glu Val Ile Ser Lys Ala
50 55 60CAC CTA AAA CAC AGC GAA TTA AAC GCT TTT TTA ATC GCC GCT CCT AGT 240His Leu Lys His Ser Glu Leu Asn Ala Phe Leu Ile Ala Ala Pro Ser65 70 75 80TAT GGT ATA GAA GCC CAA AAC GCG CTT TTA AAA ATC TTA GAA GAA CCC 288Tyr Gly Ile Glu Ala Gln Asn Ala Leu Leu Lys Ile Leu Glu Glu Pro
85 90 95CCG AAT AAC GTT TGT TTT ATC ATG TTC GCT AAA AGC CAA AAC CAT GTG 336Pro Asn Asn Val Cys Phe Ile Met Phe Ala Lys Ser Gln Asn His Val
100 105 110TTA GCC ACC ATT AAA TCC CGC CTA ATT AAA GAA GAC AAA CGC CAA AAA 384Leu Ala Thr Ile Lys Ser Arg Leu Ile Lys Glu Asp Lys Arg Gln Lys
115 120 125ATC CCC CTA AAA CCT TTA GAT TTG GAT TTA TCC AAG CTG GAT TTG AAA 432Ile Pro Leu Lys Pro Leu Asp Leu Asp Leu Ser Lys Leu Asp Leu Lys
130 135 140GAC ATT TAT GCG TTT TTA AAA AAT TTA GAC AAA GAA AAT TTT GAT TCC 480Asp Ile Tyr Ala Phe Leu Lys Asn Leu Asp Lys Glu Asn Phe Asp Ser145 150 155 160AGA GAA AAT CAG AGG GAA AGG ATT GAA AGC CTG TTA GAG AGC GTT AAC 528Arg Glu Asn Gln Arg Glu Arg Ile Glu Ser Leu Leu Glu Ser Val Asn
165 170 175AGG CAT AAG ATC CCC TTA AAC GAG CAA GAA TTG CAA GCC TTT GAT TTA 576Arg His Lys Ile Pro Leu Asn Glu Gln Glu Leu Gln Ala Phe Asp Leu
180 185 190GCG ATC AAG GCT AAC AGC TCT TAT TAC AAG CTC AGC TAT AAT CTT TTA 624Ala Ile Lys Ala Asn Ser Ser Tyr Tyr Lys Leu Ser Tyr Asn Leu Leu
195 200 205CCC CTG CTT TTA AGC CTT TTA TCC AAA AAG AAA ACG CCA TGATTGTAAA AC 675Pro Leu Leu Leu Ser Leu Leu Ser Lys Lys Lys Thr Pro
210215220 GCCTTAACCC TGATGCGCTC AAAAACGCTC T706 (706) (2) sequence 1026 data: (i) sequence characteristics: length (A): 221 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1026: gly Tyr Ser Val Lys Asn Ser Asn Arg Leu Ile Tyr Thr Asp Asn Leu 151015 Glu Glu Ser Leu Glu Glu Thr Ala Ser Leu Phe Glu His His Ile Lys
20 25 30Phe Tyr Thr Glu Ile Ile Glu Lys Asp Lys Lys Val Ile Lys Thr Phe
35 40 45Asn Lys Asp Phe Lys Ile Glu His Ala Lys Glu Val He Ser Lys Ala
50 55 60His Leu Lys His Ser Glu Leu Asn Ala Phe Leu Ile Ala Ala Pro Ser65 70 75 80Tyr Gly Ile Glu Ala Gln Asn Ala Leu Leu Lys Ile Leu Glu Glu Pro
85 90 95Pro Asn Asn Val Cys Phe Ile Met Phe Ala Lys Ser Gln Asn His Val
100 105 110Leu Ala Thr Ile Lys Ser Arg Leu Ile Lys Glu Asp Lys Arg Gln Lys
115 120 125Ile Pro Leu Lys Pro Leu Asp Leu Asp Leu Ser Lys Leu Asp Leu Lys
130 135 140Asp Ile Tyr Ala Phe Leu Lys Asn Leu Asp Lys Glu Asn Phe Asp Ser145 150 155 160Arg Glu Asn Gln Arg Glu Arg Ile Glu Ser Leu Leu Glu Ser Val Asn
165 170 175Arg His Lys Ile Pro Leu Asn Glu Gln Glu Leu Gln Ala Phe Asp Leu
180 185 190Ala Ile Lys Ala Asn Ser Ser Tyr Tyr Lys Leu Ser Tyr Asn Leu Leu
195 200 205Pro Leu Leu Leu Ser Leu Leu Ser Lys Lys Lys Thr Pro
210215220 (2) sequence 1027 data: (i) sequence characteristics: length (A): 1102bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 58...1059 (D) other information: (xi) Description of the sequence: sequence 1027: TATTCTCTCG CAATAATTGT TATTGTTATT GCGACAAAAC TTTTAGAAGG AGTTATT ATG 60
Met
1GGA AGT ATC GGT AGT ATG GGC AAA CCT ATT GAA GGG TTT TTA GTG GCA 108Gly Ser Ile Gly Ser Met Gly Lys Pro Ile Glu Gly Phe Leu Val Ala
5 10 15GCC ATT CAG TTT CCT GTG CCA ATT GTC AAT AGC CGT AAG GAT ATT GAT 156Ala Ile Gln Phe Pro Val Pro Ile Val Asn Ser Arg Lys Asp Ile Asp
20 25 30CAC AAT ATT GAA AGC ATT ATT AGA ACC TTG CAT GCG ACT AAA GCG GGG 204His Asn Ile Glu Ser Ile Ile Arg Thr Leu His Ala Thr Lys Ala Gly
35 40 45TAT CCG GGA GTG GAG CTT ATC ATT TTC CCT GAG TAT AGC ACG CAA GGT 252Tyr Pro Gly Val Glu Leu Ile Ile Phe Pro Glu Tyr Ser Thr Gln Gly50 55 60 65TTG AAT ACC GCT AAG TGG CTT AGC GAA GAG TTT TTA TTA GAT GTC CCG 300Leu Asn Thr Ala Lys Trp Leu Ser Glu Glu Phe Leu Leu Asp Val Pro
70 75 80GGT AAA GAG ACA GAG CTA TAC GCT AAG GCG TGT AAA GAG GCG AAA GTT 348Gly Lys Glu Thr Glu Leu Tyr Ala Lys Ala Cys Lys Glu Ala Lys Val
85 90 95TAT GGT GTT TTT TCA ATC ATG GAA CGC AAT CCT GAT TCT AAC AAA AAC 396Tyr Gly Val Phe Ser Ile Met Glu Arg Asn Pro Asp Ser Asn Lys Asn
100 105 110CCC TAC AAC ACC GCC ATT ATC ATT GAT CCG CAA GGT GAA ATC ATT TTA 444Pro Tyr Asn Thr Ala Ile Ile Ile Asp Pro Gln Gly Glu Ile Ile Leu
115 120 125AAA TAC CGC AAG CTA TTC CCA TGG AAT CCC ATT GAG CCA TGG TAT CCT 492Lys Tyr Arg Lys Leu Phe Pro Trp Asn Pro Ile Glu Pro Trp Tyr Pro130 135 140 145GGG GAT TTA GGA ATG CCT GTG TGC GAG GGT CCG GGC GGA TCA AAA TTA 540Gly Asp Leu Gly Met Pro Val Cys Glu Gly Pro Gly Gly Ser Lys Leu
150 155 160GCC GTG TGC ATT TGC CAT GAC GGC ATG ATT CCA GAG CTC GCC AGA GAA 588Ala Val Cys Ile Cys His Asp Gly Met Ile Pro Glu Leu Ala Arg Glu
165 170 175GCG GCC TAT AAA GGG TGC AAT GTG TAT ATC CGC ATT TCA GGC TAT AGC 636Ala Ala Tyr Lys Gly Cys Asn Val Tyr Ile Arg Ile Ser Gly Tyr Ser
180 185 190ACT CAA GTC AAT GAT CAA TGG ATT TTG ACC AAC CGC TCC AAC GCA TGG 684Thr Gln Val Asn Asp Gln Trp Ile Leu Thr Asn Arg Ser Asn Ala Trp
195 200 205CAC AAT TTG ATG TAT ACC GTG AGC GTG AAT TTA GCC GGC TAT GAT AAT 732His Asn Leu Met Tyr Thr Val Ser Val Asn Leu Ala Gly Tyr Asp Asn210 215 220 225GTC TTT TAC TAC TTT GGT GAG GGG CAA ATC TGT AAC TTT GAT GGC ACG 780Val Phe Tyr Tyr Phe Gly Glu Gly Gln IleCys Asn Phe Asp Gly Thr
230 235 240ACT CTT GTT CAA GGG CAC CGC AAC CCT TGG GAG ATT GTA ACC GGG GAA 828Thr Leu Val Gln Gly His Arg Asn Pro Trp Glu Ile Val Thr Gly Glu
245 250 255ATC TAT CCC AAA ATG GCA GAC AAC GCT CGC TTA AGC TGG GGA TTA GAA 876Ile Tyr Pro Lys Met Ala Asp Asn Ala Arg Leu Ser Trp Gly Leu Glu
260 265 270AAC AAC ATT TAC AAC CTA GGC CAT AGA GGG TAT GTG GCT AAA CCG GGC 924Asn Asn Ile Tyr Asn Leu Gly His Arg Gly Tyr Val Ala Lys Pro Gly
275 280 285GGA GAA CAT GAC GCA GGC TTA ACC TAT ATC AAA GAC TTA GCG GCC GGT 972Gly Glu His Asp Ala Gly Leu Thr Tyr Ile Lys Asp Leu Ala Ala Gly290 295 300 305AAA TAC AAA TTG CCT TGG GAA GAT CAC ATG AAA ATC AAA GAC GGC TCT 1020Lys Tyr Lys Leu Pro Trp Glu Asp His Met Lys Ile Lys Asp Gly Ser
310 315 320ATT TAT GGC TAC CCT ACC ACC GGT GGG CGT TTT GGG AAA TAATCCCTAA CC 1071Ile Tyr Gly Tyr Pro Thr Thr Gly Gly Arg Phe Gly Lys
325330 TTGCATTTTT GCTAGAACCC GTTTTTAAGG G1102, (2) sequence 1028 data: (i) sequence characteristics: length (A): 334 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1028: met Gly Ser Ile Gly Ser Met Gly Lys Pro Ile Glu Gly Phe Leu Val 151015 Ala Ala Ile Gln Phe Pro Val Pro Ile Val Asn Ser Arg Lys Asp Ile
20 25 30Asp His Asn Ile Glu Ser Ile Ile Arg Thr Leu His Ala Thr Lys Ala
35 40 45Gly Tyr Pro Gly Val Glu Leu Ile Ile Phe Pro Glu Tyr Ser Thr Gln
50 55 60Gly Leu Asn Thr Ala Lys Trp Leu Ser Glu Glu Phe Leu Leu Asp Val65 70 75 80Pro Gly Lys Glu Thr Glu Leu Tyr Ala Lys Ala Cys Lys Glu Ala Lys
85 90 95Val Tyr Gly Val Phe Ser Ile Met Glu Arg Asn Pro Asp Ser Asn Lys
100 105 110Asn Pro Tyr Asn Thr Ala Ile Ile Ile Asp Pro Gln Gly Glu Ile Ile
115 120 125Leu Lys Tyr Arg Lys Leu Phe Pro Trp Asn Pro Ile Glu Pro Trp Tyr
130 135 140Pro Gly Asp Leu Gly Met Pro Val Cys Glu Gly Pro Gly Gly Ser Lys145 150 155 160Leu Ala Val Cys Ile Cys His Asp Gly Met Ile Pro Glu Leu Ala Arg
165 170 175Glu Ala Ala Tyr Lys Gly Cys Asn Val Tyr Ile Arg Ile Ser Gly Tyr
180 185 190Ser Thr Gln Val Asn Asp Gln Trp He Leu Thr Asn Arg Ser Asn Ala
195 200 205Trp His Asn Leu Met Tyr Thr Val Ser Val Asn Leu Ala Gly Tyr Asp
210 215 220Asn Val Phe Tyr Tyr Phe Gly Glu Gly Gln Ile Cys Asn Phe Asp Gly225 230 235 240Thr Thr Leu Val Gln Gly His Arg Asn Pro Trp Glu Ile Val Thr Gly
245 250 255Glu Ile Tyr Pro Lys Met Ala Asp Asn Ala Arg Leu Ser Trp Gly Leu
260 265 270Glu Asn Asn Ile Tyr Asn LeuGly His Arg Gly Tyr Val Ala Lys Pro
275 280 285Gly Gly Glu His Asp Ala Gly Leu Thr Tyr Ile Lys Asp Leu Ala Ala
290 295 300Gly Lys Tyr Lys Leu Pro Trp Glu Asp His Met Lys Ile Lys Asp Gly305 310 315 320Ser Ile Tyr Gly Tyr Pro Thr Thr Gly Gly Arg Phe Gly Lys
325330 (2) sequence 1029 data: (i) sequence characteristics: length (A): 1152bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1095 (D) other information: (xi) Description of the sequence: sequence 1029: TAGCTATGGA TTTTCGCCGT ATTTGTGGTG GATAAAAGAA AAGGATCTTC A ATG ATT 57
Met Ile
1GCT TAC ATT CTC AAA CGC TTG CTT TTG ATT ATC CCT ACT TTA TTA GCT 105Ala Tyr Ile Leu Lys Arg Leu Leu Leu Ile Ile Pro Thr Leu Leu Ala
5 10 15ATC ATG ACC ATr AAT TTC TTT TTG ATC CAA TCG GCT CCT GGA GGC CCT 153Ile Met Thr Ile Asn Phe Phe Leu Ile Gln Ser Ala Pro Gly Gly Pro
20 25 30ATA GAG CAG ATG ATG GCT AAA ATC AAT AAC ACG CAG TCC AAA GAG ATT 201Ile Glu Gln Met Met Ala Lys Ile Asn Asn Thr Gln Ser Lys Glu Ile35 40 45 50CAA GGC GTT GTT AAA GAG CGT TCG TAT AGG GCG TCT CAA GGG TTG GAG 249Gln Gly Val Val Lys Glu Arg Ser Tyr Arg Ala Ser Gln Gly Leu Glu
55 60 65AGC GAT TTG TTA GAA AAT TTA AAA AAA CTC TAT GGT TTT GAC AAG CCC 297Ser Asp Leu Leu Glu AsnLeu Lys Lys Leu Tyr Gly Phe Asp Lys Pro
70 75 80ATA GGG GAG CGC TAC CTT CTC ATG CTC AAA AAA TAT CTG CAA TTT GAT 345Ile Gly Glu Arg Tyr Leu Leu Met Leu Lys Lys Tyr Leu Gln Phe Asp
85 90 95TTT GGG GAG AGC TTT TAT CGC CAG ATT AAA GTG ATA GAT TTG ATT AAG 393Phe Gly Glu Ser Phe Tyr Arg Gln Ile Lys Val Ile Asp Leu Ile Lys
100 105 110GAA AAA TTG CCC GTA TCC ATT TCG TTA GGG CTT TTT AGC ACG CTT TTG 441Glu Lys Leu Pro Val Ser Ile Ser Leu Gly Leu Phe Ser Thr Leu Leu115 120 125 130ATT TAT CTT ATT TCT ATC CCT TTA GGG ATT TTC AAG GCC AAA CGC AAT 489Ile Tyr Leu Ile Ser Ile Pro Leu Gly Ile Phe Lys Ala Lys Arg Asn
135 140 145AAC GAG CCT TTA GAC GTG TTA AGC AGC GTG GTG ATC ATT GTC GCT AAC 537Asn Glu Pro Leu Asp Val Leu Ser Ser Val Val Ile Ile Val Ala Asn
150 155 160GCT ATC CCG GCC TTT TTG TTT GCG GTG GTG TTG ATC GTG TTT TTT GCT 585Ala Ile Pro Ala Phe Leu Phe Ala Val Val Leu Ile Val Phe Phe Ala
165 170 175GGA GGG AAT TAT TGG CAT TGG TTC CCT TTA AAG GGG CTA GTG AGC GAT 633Gly Gly Asn Tyr Trp His Trp Phe Pro Leu Lys Gly Leu Val Ser Asp
180 185 190AAT TTT GAA AGT TTG AGC GCG TTA GGT AAA ATC AAG GAT TAT TTA TGG 681Asn Phe Glu Ser Leu Ser Ala Leu Gly Lys Ile Lys Asp Tyr Leu Trp195 200 205 210CAT ATC ACT TTG CCC GTT CTT TGC ATT TCT TTA GGG GGT TTT GCA AGC 729His Ile Thr Leu Pro Val Leu Cys Ile Ser Leu Gly Gly Phe Ala Ser
215 220225CTT ACG CTT TTA GTG AAA AAC TCT TTT TTA GAT GAA ATG GGC AAG CTC 777Leu Thr Leu Leu Val Lys Asn Ser Phe Leu Asp Glu Met Gly Lys Leu
230 235 240TAT GTA CTG AGC GCT AAG GCT AAG GGT TGT TCA GTG GGG CGT ATT TTT 825Tyr Val Leu Ser Ala Lys Ala Lys Gly Cys Ser Val Gly Arg Ile Phe
245 250 255TAT GCG CAT GTG TTC CGT AAT GCG ATT TTA TTA GTG GTG GCG GGT TTC 873Tyr Ala His Val Phe Arg Asn Ala Ile Leu Leu Val Val Ala Gly Phe
260 265 270CCG CAA GCT TTT TTG GGC ATG TTC TTT AGC TCA AGT TTG TTG ATA GAG 921Pro Gln Ala Phe Leu Gly Met Phe Phe Ser Ser Ser Leu Leu Ile Glu275 280 285 290ATT GTT TTT AGC CTA GAC GGG TTA GGG CTT TTA GGG TAT GAA AGC ATT 969Ile Val Phe Ser Leu Asp Gly Leu Gly Leu Leu Gly Tyr Glu Ser Ile
295 300 305GTG AGT AGG GAT TAT CCC GTT GTG TTT GGT TCG CTT TAT ATT TTC ACG 1017Val Ser Arg Asp Tyr Pro Val Val Phe Gly Ser Leu Tyr Ile Phe Thr
310 315 320CTT TTA GGT TTG GTA GCG AGT TTG ATA AGC GAT TTG CTC TGT GTG GTG 1065Leu Leu Gly Leu Val Ala Ser Leu Ile Ser Asp Leu Leu Cys Val Val
325 330 335ATT GAC CCT AGG ATT GAT TTT GAA AAG CGT TGAGGGTAGG AATGAAAACT GAG 1118Ile Asp Pro Arg Ile Asp Phe Glu Lys Arg
340345 ATGAAATCTT CTTTAAAACT TTTTATGCGG CCTT 1152 (2) sequence 1030 data: (i) sequence characteristics: length (A): 348 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1030: met Ile Ala Tyr Ile Leu Lys Arg Leu LeuLeu Ile Ile Pro Thr Leu 151015 Leu Ala Ile Met Thr Ile Asn Phe Phe Leu Ile Gln Ser Ala Pro Gly
20 25 30Gly Pro Ile Glu Gln Met Met Ala Lys Ile Asn Asn Thr Gln Ser Lys
35 40 45Glu Ile Gln Gly Val Val Lys Glu Arg Ser Tyr Arg Ala Ser Gln Gly
50 55 60Leu Glu Ser Asp Leu Leu Glu Asn Leu Lys Lys Leu Tyr Gly Phe Asp65 70 75 80Lys Pro Ile Gly Glu Arg Tyr Leu Leu Met Leu Lys Lys Tyr Leu Gln
85 90 95Phe Asp Phe Gly Glu Ser Phe Tyr Arg Gln Ile Lys Val Ile Asp Leu
100 105 110Ile Lys Glu Lys Leu Pro Val Ser Ile Ser Leu Gly Leu Phe Ser Thr
115 120 125Leu Leu Ile Tyr Leu Ile Ser Ile Pro Leu Gly Ile Phe Lys Ala Lys
130 135 140Arg Asn Asn Glu Pro Leu Asp Val Leu Ser Ser Val Val Ile Ile Val145 150 155 160Ala Asn Ala Ile Pro Ala Phe Leu Phe Ala Val Val Leu Ile Val Phe
165 170 175Phe Ala Gly Gly Asn Tyr Trp His Trp Phe Pro Leu Lys Gly Leu Val
180 185 190Ser Asp Asn Phe Glu Ser Leu Ser Ala Leu Gly Lys Ile Lys Asp Tyr
195 200 205Leu Trp His Ile Thr Leu Pro Val Leu Cys Ile Ser Leu Gly Gly Phe
210 215 220Ala Ser Leu Thr Leu Leu Val Lys Asn Ser Phe Leu Asp Glu Met Gly225 230 235 240Lys Leu Tyr Val Leu Ser Ala Lys Ala Lys Gly Cys Ser Val Gly Arg
245 250 255Ile Phe Tyr Ala His Val Phe Arg Asn Ala Ile Leu Leu Val Val Ala
260 265 270Gly Phe Pro Gln Ala Phe Leu Gly Met Phe Phe Ser Ser Ser Leu Leu
275 280 285Ile Glu Ile Val Phe Ser Leu Asp Gly Leu Gly Leu Leu Gly Tyr Glu
290 295 300Ser Ile Val Ser Arg Asp Tyr Pro Val Val Phe Gly Ser Leu Tyr Ile305 310 315 320Phe Thr Leu Leu Gly Leu Val Ala Ser Leu Ile Ser Asp Leu Leu Cys
325 330 335Val Val Ile Asp Pro Arg Ile Asp Phe Glu Lys Arg
340345 (2) sequence 1031 data: (i) sequence characteristics: length (A): 662bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 618 (D) other information: (xi) Description of the sequence: sequence 1031: TTAAAGGTCT AAACC ATG GAT ATT AAG GCA TGT TAT CAA AAC GCT AAA GCG 51
Met Asp Ile Lys Ala Cys Tyr Gln Asn Ala Lys Ala
1 5 10TTA TTA GAG GGG CAT TTC TTG CTC AGC AGT GGG TTT CAT TCC AAT TAT 99Leu Leu Glu Gly His Phe Leu Leu Ser Ser Gly Phe His Ser Asn Tyr
15 20 25TAT TTG CAA TCC GCT AAA GTT TTA GAA GAT CCC AAA CTA GCC GAA CAA 147Tyr Leu Gln Ser Ala Lys Val Leu Glu Asp Pro Lys Leu Ala Glu Gln
30 35 40TTA GCG CTA GAA TTA GCC AAA CAAATC CAA GAA GCT CAT TTG AAT ATT 195Leu Ala Leu Glu Leu Ala Lys Gln Ile Gln Glu Ala His Leu Asn Ile45 50 55 60GAA TGC GTG TGC TCA CCG GCT ATT GGG GGG ATT TTG GCT GGG TAT GAG 243Glu Cys Val Cys Ser Pro Ala Ile Gly Gly Ile Leu Ala Gly Tyr Glu
65 70 75CTT GCA AGG GCT TTG GGC GTG CGT TTT ATC TTC ACC GAA AGG GTG GAT 291Leu Ala Arg Ala Leu Gly Val Arg Phe Ile Phe Thr Glu Arg Val Asp
80 85 90AAT ACC ATG GCG TTA AGG CGT GGC TTT GAA GTC AAA AAA AAC GAA AAA 339Asn Thr Met Ala Leu Arg Arg Gly Phe Glu Val Lys Lys Asn Glu Lys
95 100 105ATT TTA GTG TGT GAG GAC ATT ATC ACT ACG GGA AAA TCC GCT ATG GAA 387Ile Leu Val Cys Glu Asp Ile Ile Thr Thr Gly Lys Ser Ala Met Glu
110 115 120TGC GCT AAA GTT TTA GAA GAA AAG GGT GCT CAA ATC GTG GCT TTT GGT 435Cys Ala Lys Val Leu Glu Glu Lys Gly Ala Gln Ile Val Ala Phe Gly125 130 135 140GCT TTA GCT AAT CGG GGC ATT TGC AAG CGT GCT CAT TCT CAT TTA AAA 483Ala Leu Ala Asn Arg Gly Ile Cys Lys Arg Ala His Ser His Leu Lys
145 150 155GCC CAA GAG GGA GCG TGT TTG CCT AGC CAT TTG CCC CTT TTT GCT TTA 531Ala Gln Glu Gly Ala Cys Leu Pro Ser His Leu Pro Leu Phe Ala Leu
160 165 170GAA GAT TTT GTT TTT GAC ATG CAC AAG CCT AGT TCT TGC CCT TTA TGC 579Glu Asp Phe Val Phe Asp Met His Lys Pro Ser Ser Cys Pro Leu Cys
175 180 185GCT ACT AGC GTT GCT ATA AAG CCA GGA AGT CGT GGC AAC TAAAAAAACA AA 630Ala Thr Ser Val Ala Ile Lys ProGly Ser Arg Gly Asn
190195200 AAAAAATAAA ACCCCAAAAA AAAAGCAAGC GT 662 (2) sequence 1032 data: (i) sequence characteristics: length (A): 201 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1032: met Asp Ile Lys Ala Cys Tyr Gln Asn Ala Lys Ala Leu Leu Glu Gly 151015 His Phe Leu Leu Ser Ser Gly Phe His Ser Asn Tyr Tyr Leu Gln Ser
20 25 30Ala Lys Val Leu Glu Asp Pro Lys Leu Ala Glu Gln Leu Ala Leu Glu
35 40 45Leu Ala Lys Gln Ile Gln Glu Ala His Leu Asn Ile Glu Cys Val Cys
50 55 60Ser Pro Ala Ile Gly Gly Ile Leu Ala Gly Tyr Glu Leu Ala Arg Ala65 70 75 80Leu Gly Val Arg Phe Ile Phe Thr Glu Arg Val Asp Asn Thr Met Ala
85 90 95Leu Arg Arg Gly Phe Glu Val Lys Lys Asn Glu Lys Ile Leu Val Cys
100 105 110Glu Asp Ile Ile Thr Thr Gly Lys Ser Ala Met Glu Cys Ala Lys Val
115 120 125Leu Glu Glu Lys Gly Ala Gln Ile Val Ala Phe Gly Ala Leu Ala Asn
130 135 140Arg Gly Ile Cys Lys Arg Ala His Ser His Leu Lys Ala Gln Glu Gly145 150 155 160Ala Cys Leu Pro Ser His Leu Pro Leu Phe Ala Leu Glu Asp Phe Val
165 170 175Phe Asp Met His Lys Pro Ser Ser Cys Pro Leu Cys Ala Thr Ser Val
180 185 190Ala Ile Lys Pro Gly Ser Arg Gly Asn
195200 (2) sequence 1033 data: (i) sequence characteristics: length (A): 401bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 384 (D) other information: (xi) Description of the sequence: sequence 1033: CTCTCTTTGC GCCTAAAGGC CTTTATCACC GATATTTTT ATG ATT TAT ACC CCC 54
Met Ile Tyr Thr Pro
1 5ATG CTT TAT ATA ATG ACT TAT GCG ATT TTA GGG AGC GCG AAG GAT TTT 102Met Leu Tyr Ile Met Thr Tyr Ala Ile Leu Gly Ser Ala Lys Asp Phe
10 15 20AGG GAA AAC CAG AGC GCG ATT TTT TTA TGC CTG CTT TTT TAC GCC CTA 150Arg Glu Asn Gln Ser Ala Ile Phe Leu Cys Leu Leu Phe Tyr Ala Leu
25 30 35ACA CAC AGC TTT TTT ATC GCT TTT AAA TCC CAA AGC CCT GGC ATG CGT 198Thr His Ser Phe Phe Ile Ala Phe Lys Ser Gln Ser Pro Gly Met Arg
40 45 50TAC GCT CGG TTT AAA TTA ATC AAA AAT AAT GGC GAA AAA GTG GGC TTT 246Tyr Ala Arg Phe Lys Leu Ile Lys Asn Asn Gly Glu Lys Val Gly Phe
55 60 65TTT TTA GCT TTG TGG CGC TTT GTT TTG TGG GTG TTG AGC ATG GGG TTA 294Phe Leu Ala Leu Trp Arg Phe Val Leu Trp Val Leu Ser Met Gly Leu70 75 80 85CTC ATA GGG TTT GTT ACG CCT TTT ATT TTT AAG TTT TTT TTG CAT GAC 342Leu Ile Gly Phe Val Thr Pro Phe Ile Phe Lys Phe Phe Leu His Asp
90 95 100AAA CTC AGC GGC ACT CAT ATT GAA ACC ATC AAG GAG GCA ACA TGAAAAATT 393Lys Leu Ser GlyThr His Ile Glu Thr Ile Lys Glu Ala Thr
105 110 115TAGTAATC 401
(2) Sequence 1034 data: (i) sequence characteristics:
(A) length: 115 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: linear (ii) molecular type: protein (xi) sequence description: sequence 1034: met Ile Tyr Thr Pro Met Leu Tyr Ile Met Thr Tyr Ala Ile Leu Gly 151015 Ser Ala Lys Asp Phe Arg Glu Asn Gln Ser Ala Ile Phe Leu Cys Leu
20 25 30Leu Phe Tyr Ala Leu Thr His Ser Phe Phe Ile Ala Phe Lys Ser Gln
35 40 45Ser Pro Gly Met Arg Tyr Ala Arg Phe Lys Leu Ile Lys Asn Asn Gly
50 55 60Glu Lys Val Gly Phe Phe Leu Ala Leu Trp Arg Phe Val Leu Trp Val65 70 75 80Leu Ser Met Gly Leu Leu Ile Gly Phe Val Thr Pro Phe Ile Phe Lys
85 90 95Phe Phe Leu His Asp Lys Leu Ser Gly Thr His Ile Glu Thr Ile Lys
100 105 110Glu Ala Thr
115 (2) sequence 1035 data: (i) sequence characteristics: length (A): 717bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 53...667 (D) other information: (xi) Description of the sequence: sequence 1035: AGCGGGGCTG GTATTTCAGC AGAAAGCGGG ATTAAAACCT TTAGAGACGC TG ATG GCT 58
Met Ala
1TGT GGG AAA GGG CAT GAC ATC ATG GAA GTT GCC TCG CCT TAT GGC TGG 106Cys Gly Lys Gly His Asp Ile Met Glu Val Ala Ser Pro Tyr Gly Trp
5 10 15AAA AAG AAC CCG CAA AAG GTG TTG GAT TTT TAC AAC CAA AGG CGC CGA 154Lys Lys Asn Pro Gln Lys Val Leu Asp Phe Tyr Asn Gln Arg Arg Arg
20 25 30CAG CTT TTT GAA GTT TAT CCT AAC AAA GCC CAT AAG GCT TTA GCG GAA 202Gln Leu Phe Glu Val Tyr Pro Asn Lys Ala His Lys Ala Leu Ala Glu35 40 45 50TTG GAA AAA CAC TAT CAA GTC AAT ATC ATC ACC CAA AAT GTA GAT GAT 250Leu Glu Lys His Tyr Gln Val Asn Ile Ile Thr Gln Asn Val Asp Asp
55 60 65TTG CAT GAA AGA GCG GGT TCT TCT CGC ATT TTG CAC TTG CAT GGG GAA 298Leu His Glu Arg Ala Gly Ser Ser Arg Ile Leu His Leu His Gly Glu
70 75 80TTA TTG AGC GTT CGC AGC GAG AAA GAT CCT AAT TTA GTT TAT AGG TGG 346Leu Leu Ser Val Arg Ser Glu Lys Asp Pro Asn Leu Val Tyr Arg Trp
85 90 95GAA AAG GAC TTG AAT TTA GGC GAC TTG GCC AAA GAC AAA TCG CAA TTA 394Glu Lys Asp Leu Asn Leu Gly Asp Leu Ala Lys Asp Lys Ser Gln Leu
100 105 110CGC CCT GAT ATT GTG TGG TTT GGC GAA GCG GTG CCT TTG CTT AAA GAA 442Arg Pro Asp Ile Val Trp Phe Gly Glu Ala Val Pro Leu Leu Lys Glu115 120 125 130GCG ATT TCT TTA GTC AAA CAA GCG CAT CTT TTA ATC ATC ATT GGC ACT 490Ala Ile Ser Leu Val Lys Gln Ala His Leu Leu Ile Ile Ile GlyThr
135 140 145TCT TTG CAA GTC TAT CCC GCC GCT AGC CTC TAC ACG CAT GCG CAT AAA 538Ser Leu Gln Val Tyr Pro Ala Ala Ser Leu Tyr Thr His Ala His Lys
150 155 160GAC GCT CTC ATT TAT TAC ATT GAC CCT AAG GCT AAA AAC GCC CAT TTA 586Asp Ala Leu Ile Tyr Tyr Ile Asp Pro Lys Ala Lys Asn Ala His Leu
165 170 175CCC CAG AAT GTC CAA TGC ATT AAT GAA AGC GCG GTG CAT GCC ATG CAA 634Pro Gln Asn Val Gln Cys Ile Asn Glu Ser Ala Val His Ala Met Gln
180185190 GAT TTA ATG CCC AAA CTC ATA GAA ATG GCT TCT TAAGAAATGT TAAAATAATT 687Asp Leu Met Pro Lys Leu Ile Glu Met Ala Ser 195200205 TTTATTTTTT CAGCTAACGA TTAGCAAAAA 717 (2) sequence 1036 data: (i) sequence characteristics: length (A): 205 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii molecular type protein (xi) sequence description: sequence 1036: Met Ala Cys Gly Lys Gly His Asp Ile Met Glu Val Ala Ser Pro Tyr 151015 Gly Trp Lys Lys Asn Pro Gln Lys Val Leu Asp Phe Tyr Asn Gln Arg
20 25 30Arg Arg Gln Leu Phe Glu Val Tyr Pro Asn Lys Ala His Lys Ala Leu
35 40 45Ala Glu Leu Glu Lys His Tyr Gln Val Asn Ile Ile Thr Gln Asn Val
50 55 60Asp Asp Leu His Glu Arg Ala Gly Ser Ser Arg Ile Leu His Leu His65 70 75 80Gly Glu Leu Leu Ser Val Arg Ser Glu Lys Asp Pro Asn Leu Val Tyr
85 90 95Arg Trp Glu Lys Asp Leu Asn Leu Gly Asp Leu Ala Lys Asp Lys Ser
100 105 110Gln Leu Arg Pro Asp Ile Val Trp Phe Gly Glu Ala Val Pro Leu Leu
115 120 125Lys Glu Ala Ile Ser Leu Val Lys Gln Ala His Leu Leu Ile Ile Ile
130 135 140Gly Thr Ser Leu Gln Val Tyr Pro Ala Ala Ser Leu Tyr Thr His Ala145 150 155 160His Lys Asp Ala Leu Ile Tyr Tyr Ile Asp Pro Lys Ala Lys Asn Ala
165 170 175His Leu Pro Gln Asn Val Gln Cys Ile Asn Glu Ser Ala Val His Ala
180 185 190Met Gln Asp Leu Met Pro Lys Leu Ile Glu Met Ala Ser
195200205 (2) sequence 1037 data: (i) sequence characteristics: length (A): 468bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 421 (D) other information: (xi) Description of the sequence: sequence 1037: ATTAAAGGAG TTTGAGAGTC TG ATG CAA CAA GCC ACA GAA GCA TTG AAT CAC 52
Met Gln Gln Ala Thr Glu Ala Leu Asn His
1 5 10CCC TAT TTT GGC GTT TTT GTT TTA TTG GTA TTC ACC TTT TGG GTG TTT 100Pro Tyr Phe Gly Val Phe Val Leu Leu Val Phe Thr Phe Trp Val Phe
15 20 25AAC TTA ACC TTA AGG ATC CAA AGG TTT TTA AGC CGT AAA ATG GCT CAA 148Asn Leu Thr Leu Arg Ile Gln Arg Phe Leu Ser Arg Lys Met Ala Gln
30 35 40AAA AAG GGC GAA AAG CTC AAG CTC GCT CCC TAT GAA TGC GGG CCT GTG 196Lys Lys Gly Glu Lys Leu Lys Leu Ala Pro Tyr Glu Cys Gly Pro Val
45 50 55GCT CTC AAA CAG CCT AAT AGG GTG TCG CAC CAT TTC TAT ATC ATG GCC 244Ala Leu Lys Gln Pro Asn Arg Val Ser His His Phe Tyr Ile Met Ala
60 65 70ATG CTT TTT ATT TTA TTT GAT GTA GAA ATC GTT TTC ATG TTC CCT TGG 292Met Leu Phe Ile Leu Phe Asp Val Glu Ile Val Phe Met Phe Pro Trp75 80 85 90GCG ATT GGT TTT AAA AAA TTA GGC TTG TTT GGA CTC GTT GAA ATG CTA 340Ala Ile Gly Phe Lys Lys Leu Gly Leu Phe Gly Leu Val Glu Met Leu
95 100 105GGC TTT GTC TTC TTT TTA ACC ATT GGT TTT ATT TAC GCT TTA AAG CGA 388Gly Phe Val Phe Phe Leu Thr Ile Gly Phe Ile Tyr Ala Leu Lys Arg
110 115 120AAC GCT TTG AGC TGG CAA AAA TTA GAG GTG AAA TAATGCAACA AGCACCGGTT 441Asn Ala Leu Ser Trp Gln Lys Leu Glu Val Lys
125130 GTTCTAAGCA CTTTGGATAA ATTATTG 468 (2) sequence 1038 data: (i) sequence characteristics: length (A): 133 amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1038: met Gln Gln Ala Thr Glu Ala Leu Asn His Pro Tyr Phe Gly Val Phe 151015 Val Leu Leu Val Phe Thr Phe Trp Val Phe Asn Leu Thr Leu Arg Ile
20 25 30Gln Arg Phe Leu Ser Arg Lys Met Ala Gln Lys Lys Gly Glu Lys Leu
35 40 45Lys Leu Ala Pro Tyr Glu Cys Gly Pro Val Ala Leu Lys Gln Pro Asn
50 55 60Arg Val Ser His His Phe Tyr Ile Met Ala Met Leu Phe Ile Leu Phe65 70 75 80Asp Val Glu Ile Val Phe Met Phe Pro Trp Ala Ile Gly Phe Lys Lys
85 90 95Leu Gly Leu Phe Gly Leu Val Glu Met Leu Gly Phe Val Phe Phe Leu
100 105 110Thr Ile Gly Phe Ile Tyr Ala Leu Lys Arg Asn Ala Leu Ser Trp Gln
115 120 125Lys Leu Glu Val Lys
130 (2) sequence 1039 data: (i) sequence characteristics: length (A): 864bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): other information of 831 (D): (xi) Description of the sequence: sequence 1039: AGCGATCAAA CAAGACGCTC CCAAAAGGTT AGTGTG ATG GTA AGA AAA CAA TCC 54
Met Val Arg Lys Gln Ser
1 5CCC TAT GAA GAT GTG CAA AAA CAA TCG CGC CAG CAT GAC CCC TAT AAA 102Pro Tyr Glu Asp Val Gln Lys Gln Ser Arg Gln His Asp Pro Tyr Lys
10 15 20ATC ATA GAA CCC ACC CCT AAA AAA TAT TTA GAG GGC AGC GCT TAT GAG 150Ile Ile Glu Pro Thr Pro Lys Lys Tyr Leu Glu Gly Ser Ala Tyr Glu
25 30 35GTC ATT TAC AAC CAC CTT TCT TAC AAA CAT GAG ATT TTA GAC AAA TAC 198Val Ile Tyr Asn His Leu Ser Tyr Lys His Glu Ile Leu Asp Lys Tyr
40 45 50ATA GAG ACT AAC ACG GCT GTG TTT TGG ATC AAA AAA GAC GAT ATT TTT 246Ile Glu Thr Asn Thr Ala Val Phe Trp Ile Lys Lys Asp Asp Ile Phe55 60 65 70TCT GTC GCT ACG ATT TTA AGG CAT TTG GGT TAT GAG TGT TTG AGC GAA 294Ser ValAla Thr Ile Leu Arg His Leu Gly Tyr Glu Cys Leu Ser Glu
75 80 85ATG AGC GCG ATA GAT TTG TGC GCT AAA AAA GGG CAT TTT GAA TTG TTT 342Met Ser Ala Ile Asp Leu Cys Ala Lys Lys Gly His Phe Glu Leu Phe
90 95 100TAT CAG TTC GTG GGC TTT AGC GAT AGC TGC AAG AAC CGC CGT AGG NTG 390Tyr Gln Phe Val Gly Phe Ser Asp Ser Cys Lys Asn Arg Arg Arg Xaa
105 110 115CGC GTG AAG TGC GTT TTG TTG CCT AAT GAG AGC GTG GAT TCT TTG AGT 438Arg Val Lys Cys Val Leu Leu Pro Asn Glu Ser Val Asp Ser Leu Ser
120 125 130TTT TTA TAC CGA TCG GCT AAT TGG AGC GAA AGG GAA GCG TAT GAC ATG 486Phe Leu Tyr Arg Ser Ala Asn Trp Ser Glu Arg Glu Ala Tyr Asp Met135 140 145 150CTT GGT ATT GTG TTT GAC AAA CAC CCC TAT TTG AAA CGC CTT ATT ATG 534Leu Gly Ile Val Phe Asp Lys His Pro Tyr Leu Lys Arg Leu Ile Met
155 160 165CCG CAT GAT TGG GTA GGC CAC CCA TTA TTG CGC TCT TAC CCG CTC AAA 582Pro His Asp Trp Val Gly His Pro Leu Leu Arg Ser Tyr Pro Leu Lys
170 175 180GGC GAT GAA TTC GCC CAA TGG TAT GAA GTG GAT AAA ATT TTT GGT AAA 630Gly Asp Glu Phe Ala Gln Trp Tyr Glu Val Asp Lys Ile Phe Gly Lys
185 190 195GAA TAC CGA GAA GTG GTG GGT AAA GAG CAG AGA GAC AGC GCA AGA GTG 678Glu Tyr Arg Glu Val Val Gly Lys Glu Gln Arg Asp Ser Ala Arg Val
200 205 210GAT GAA AAA GAC ACT TTC AAT TTT GCA AAA ATT GGC TAT GAA CAG GGC 726Asp Glu Lys Asp Thr Phe Asn Phe Ala Lys Ile Gly Tyr Glu Gln Gly215 220 225 230AAG GGC GAA GAA TTA AAA GAA GTA GAA GAA AAG CAT GCG TTT AAG AAA 774Lys Gly Glu Glu Leu Lys Glu Val Glu Glu Lys His Ala Phe Lys Lys
235 240 245ATC CCT TTT GTC AAA GAT TTG CAC AAA ATC GCC CCC ACT ATC TTA AAA 822Ile Pro Phe Val Lys Asp Leu His Lys Ile Ala Pro Thr Ile Leu Lys
250 255 260AAG AGG CTA TAAAATGGCT CAAAATTTCA CGAAACTCAA CCC 864Lys Arg Leu
265 (2) sequence 1040 data: (i) sequence characteristics: length (A): 265 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1040: met Val Arg Lys Gln Ser Pro Tyr Glu Asp Val Gln Lys Gln Ser Arg 151015 Gln His Asp Pro Tyr Lys Ile Ile Glu Pro Thr Pro Lys Lys Tyr Leu
20 25 30Glu Gly Ser Ala Tyr Glu Val Ile Tyr Asn His Leu Ser Tyr Lys His
35 40 45Glu Ile Leu Asp Lys Tyr Ile Glu Thr Asn Thr Ala Val Phe Trp Ile
50 55 60Lys Lys Asp Asp Ile Phe Ser Val Ala Thr Ile Leu Arg His Leu Gly65 70 75 80Tyr Glu Cys Leu Ser Glu Met Ser Ala Ile Asp Leu Cys Ala Lys Lys
85 90 95Gly His Phe Glu Leu Phe Tyr Gln Phe Val Gly Phe Ser Asp Ser Cys
100 105 110Lys Asn Arg Arg Arg Xaa Arg Val Lys Cys Val Leu Leu Pro Asn Glu
115 120 125Ser Val Asp Ser Leu Ser Phe Leu Tyr Arg Ser Ala Asn Trp Ser Glu
130 135 140Arg Glu Ala Tyr Asp Met Leu Gly Ile Val Phe Asp Lys His Pro Tyr145 150 155 160Leu Lys Arg Leu Ile Met Pro His Asp Trp Val Gly His Pro Leu Leu
165 170 175Arg Ser Tyr Pro Leu Lys Gly Asp Glu Phe Ala Gln Trp Tyr Glu Val
180 185 190Asp Lys Ile Phe Gly Lys Glu Tyr Arg Glu Val Val Gly Lys Glu Gln
195 200 205Arg Asp Ser Ala Arg Val Asp Glu Lys Asp Thr Phe Asn Phe Ala Lys
210 215 220Ile Gly Tyr Glu Gln Gly Lys Gly Glu Glu Leu Lys Glu Val Glu Glu225 230 235 240Lys His Ala Phe Lys Lys Ile Pro Phe Val Lys Asp Leu His Lys Ile
245 250 255Ala Pro Thr Ile Leu Lys Lys Arg Leu
260265 (2) data for sequence 1041: (i) sequence characteristics: length (A): 2623bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 2580 (D) other information: (xi) Description of the sequence: sequence 1041: TGACGCTTAC CCTTATATCC CTATTTTATC CCACTCTCAAGGAATTTC ATG ATC ACA 57
Met Ile Thr
1ATG AAT ATC AAT GGC AAA ACG ATT GAA TGC CAA GAG GGA CAA AGC GTT 105Met Asn Ile Asn Gly Lys Thr Ile Glu Cys Gln Glu Gly Gln Ser Val
5 10 15TTA GAG GCT GCT AGG AGC GCT GGG ATC TAC ATC CCT ACC ATT TGC TAT 153Leu Glu Ala Ala Arg Ser Ala Gly Ile Tyr Ile Pro Thr Ile Cys Tyr20 25 30 35TTA AGC GGT TGC TCG CCC ACA GTC GCA TGC AAA ATG TGC ATG GTT GAA 201Leu Ser Gly Cys Ser Pro Thr Val Ala Cys Lys Met Cys Met Val Glu
40 45 50ATG GAT GGC AAA CGG GTT TAT AGC TGC AAC ACG AAA GCC AAA AAC AAC 249Met Asp Gly Lys Arg Val Tyr Ser Cys Asn Thr Lys Ala Lys Asn Asn
55 60 65GCC ACC ATT CTC ACT AAC ACC CCA ACG CTC ATG GAT GAA AGA AAA AGC 297Ala Thr Ile Leu Thr Asn Thr Pro Thr Leu Met Asp Glu Arg Lys Ser
70 75 80ATC ATG CAA ACT TAT GAT GTC AAC CAC CCC CTA GAG TGT GGC GTG TGC 345Ile Met Gln Thr Tyr Asp Val Asn His Pro Leu Glu Cys Gly Val Cys
85 90 95GAT AAG AGT GGG GAG TGC GAA TTG CAA GAC ATG ACG CAT TTA ACC GGC 393Asp Lys Ser Gly Glu Cys Glu Leu Gln Asp Met Thr His Leu Thr Gly100 105 110 115GTA GAG CAC CAA CCC TAT GCG GTG GCT GAT GAT TTT AAA GCA CTG GAT 441Val Glu His Gln Pro Tyr Ala Val Ala Asp Asp Phe Lys Ala Leu Asp
120 125 130TTT TGG GCA AAA GCC TTG TAT GAT CCT AAT TTG TGC ATC ATG TGT GAA 489Phe Trp Ala Lys Ala Leu Tyr Asp Pro Asn Leu Cys Ile Met Cys Glu
135 140 145AGG TGC GTA ACC ACT TGT AAG GAC AAT GTG GGC GAA AAC AAC CTT AAA 537Arg Cys Val Thr Thr Cys Lys Asp Asn Val Gly Glu Asn Asn Leu Lys
150 155 160GCC ACT AAA GCC GAC TTG CAT GCT CCG GAT AAA TTT AAA GAC AGC ATG 585Ala Thr Lys Ala Asp Leu His Ala Pro Asp Lys Phe Lys Asp Ser Met
165 170 175TCC AAA GAC GCT TTT AGC GTG TGG AGT CGT AAG CAA AAA GGC ATT ATT 633Ser Lys Asp Ala Phe Ser Val Trp Ser Arg Lys Gln Lys Gly Ile Ile180 185 190 195TCT TTT GTG GGC AGC GTG CCT TGC TAT GAT TGC GGG GAA TGC ATT GCA 681Ser Phe Val Gly Ser Val Pro Cys Tyr Asp Cys Cly Glu Cys Ile Ala
200 205 210GTA TGC CCT GTG GGC GCT TTG AGC TAT AAA GAT TTC GCT TAC ACG GCT 729Val Cys Pro Val Gly Ala Leu Ser Tyr Lys Asp Phe Ala Tyr Thr Ala
215 220 225AAC GCA TGG GAG TTA AAA AAG ATC CAT TCT ACT TGT TCG CAT TGC TCG 777Asn Ala Trp Glu Leu Lys Lys Ile His Ser Thr Cys Ser His Cys Ser
230 235 240GCC GGG TGT TTG ATT TCT TAT GAT GTG CGC CAT TTT GAT ACT CTA GGC 825Ala Gly Cys Leu Ile Ser Tyr Asp Val Arg His Phe Asp Thr Leu Gly
245 250 255GAA GAA TCT AAA ATT TTT AGA GTG CTT AAT GAT TTT TAC CAT AAC CCT 873Glu Glu Ser Lys Ile Phe Arg Val Leu Asn Asp Phe Tyr His Asn Pro260 265 270 275ATT TGT GGG GCA GGC CGT TTC GCT TTT GAT GTG AGC TCT AGC CCT AAA 921Ile Cys Gly Ala Gly Arg Phe Ala Phe Asp Val Ser Ser Ser Pro Lys
280 285 290GGC AGT GCT AAT CTT AAA GAA GCG CAA AAC GCC CTC AAA GAA TGC GAA 969Gly Ser Ala Asn Leu Lys Glu Ala Gln Asn Ala Leu Lys Glu Cys Glu
295 300 305GCG GTG CGA ATA GGT GGG GAT ATT ACG AAT GAA GAG GCG TTT TTA ATA 1017Ala Val Arg Ile Gly Gly Asp Ile Thr Asn Glu Glu Ala Phe Leu Ile
310 315 320GAG CGT TTA AGA AAAGAG CTT GAT TTT AAA ATC TAC AAT CAA GAA GCG 1065Glu Arg Leu Arg Lys Glu Leu Asp Phe Lys Ile Tyr Asn Gln Glu Ala
325 330 335TAT CGT TTC CAG CAA TTC TTA AAA GTA TTG GGC GAA ATT AAA CGC CCC 1113Tyr Arg Phe Gln Gln Phe Leu Lys Val Leu Gly Glu Ile Lys Arg Pro340 345 350 355AGC GTT GAA GAG ATT AAA ACT TCT CAT TTA GTC GTT ACG ATA GGA TCT 1161Ser Val Glu Glu Ile Lys Thr Ser His Leu Val Val Thr Ile Gly Ser
360 365 370TCT ATC AAA ACA GAA AAC CCT TTG GTG CGC TAT GCC ATC AAT AAC GCT 1209Ser Ile Lys Thr Glu Asn Pro Leu Val Arg Tyr Ala Ile Asn Asn Ala
375 380 385CTC AAA CTC AAT AAA GCT TCT TTA ATC GCT ATG CAC CCT ATT AAG GAT 1257Leu Lys Leu Asn Lys Ala Ser Leu Ile Ala Met His Pro Ile Lys Asp
390 395 400AAC GCG CTA GCG AAT TTG TGC CGA AGC TCT TTT TGC ATC ACC CAT GAA 1305Asn Ala Leu Ala Asn Leu Cys Arg Ser Ser Phe Cys Ile Thr His Glu
405 410 415GTG GGG GCT GAA GAA ATC CTT TTA GGC ATG CTT TTA AAA ATG CTT AAC 1353Val Gly Ala Glu Glu Ile Leu Leu Gly Met Leu Leu Lys Met Leu Asn420 425 430 435ATT GAA AGC GCG GCC CTA AAA AGC TTA GAA GAT TCC AAG CAA AAT ATT 1401Ile Glu Ser Ala Ala Leu Lys Ser Leu Glu Asp Ser Lys Gln Asn Ile
440 445 450GTA GAT GAA GCG GCT CTT AAA GCC TTA GAA GAA GAG CGA AAA AAA GCT 1449Val Asp Glu Ala Ala Leu Lys Ala Leu Glu Glu Glu Arg Lys Lys Ala
455 460 465TTA GAA CAA GCC GAG CAA GGG TGC AGT ATT GGA GAA AAT AAG GCA GAA 1497Leu Glu Gln Ala GluGln Gly Cys Ser Ile Gly Glu Asn Lys Ala Glu
470 475 480AAT CAA GAA GAG AAT AAA ACA GAA GCG ACT ACC CCA AAA GAA GAA AAT 1545Asn Gln Glu Glu Asn Lys Thr Glu Ala Thr Thr Pro Lys Glu Glu Asn
485 490 495CAA GAA GAA AAC AAG ACA GAG GTT AAA GAA GAA AAA ATT GAA GTC CCT 1593Gln Glu Glu Asn Lys Thr Glu Val Lys Glu Glu Lys Ile Glu Val Pro500 505 510 515ACC AAA ACC ACT TAT TTG CTG CTT GAA GAA GCG GGC ATC AAT TTA GAA 1641Thr Lys Thr Thr Tyr Leu Leu Leu Glu Glu Ala Gly Ile Asn Leu Glu
520 525 530ACT TAT GAA AAA ATT CTG GCT CTT TTG CAA AAA TCA AAT AAC ACC CTG 1689Thr Tyr Glu Lys Ile Leu Ala Leu Leu Gln Lys Ser Asn Asn Thr Leu
535 540 545CTA GTG GTT GGC GAA GAA ATC TAT AGC CAT AAG CAA GCC CAC AAT ATC 1737Leu Val Val Gly Glu Glu Ile Tyr Ser His Lys Gln Ala His Asn Ile
550 555 560GCT AAA ATG TTG CGT TTG CTA GCC CAA AAA AGC GCT ATT AAA CTC ATT 1785Ala Lys Met Leu Arg Leu Leu Ala Gln Lys Ser Ala Ile Lys Leu Ile
565 570 575CTT ATC CCC CCA AGC GCC AAC GCT TTA GGC ATC GCT TCT ATT TGT CAA 1833Leu Ile Pro Pro Ser Ala Asn Ala Leu Gly Ile Ala Ser Ile Cys Gln580 585 590 595TTG AGC GAA GAA ATT TTT GAA CAT GAA AAA ATT GTA GGC ATT CGC GCT 1881Leu Ser Glu Glu Ile Phe Glu His Glu Lys Ile Val Gly Ile Arg Ala
600 605 610CAA GGG GAT TTC ACT ATC AAT AGC GAT GAT AGG GTT TTT GGA AAA GAC 1929Gln Gly Asp Phe Thr Ile Asn Ser Asp Asp Arg Val Phe Gly Lys Asp
615 620 625GCT GCC AGC AAA GTG GAT TTT ATT TTA CCC AGT CTC AAC CAG CTA GAA 1977Ala Ala Ser Lys Val Asp Phe Ile Leu Pro Ser Leu Asn Gln Leu Glu
630 635 640GGC ACG ATC ACC AAT ATT GAA GGG CGT GTG TTG CCC TTA AAA CCG GCT 2025Gly Thr Ile Thr Asn Ile Glu Gly Arg Val Leu Pro Leu Lys Pro Ala
645 650 655TTG AGG TTT GAG GGC TAT GAT TTG AGC GAT ATT ATG CAA GGC TTT GGC 2073Leu Arg Phe Glu Gly Tyr Asp Leu Ser Asp Ile Met Gln Gly Phe Gly660 665 670 675TTT GTG GAA GAA AAC CTC ATA GAA TGC ACC CAC AAA CTC CCT ACA GAA 2121Phe Val Glu Glu Asn Leu Ile Glu Cys Thr His Lys Leu Pro Thr Glu
680 685 690GCG GGC TTT AAA GCC ATA GAA TTT GAT TAT TTA ACC AAC TAT TTC GCT 2169Ala Gly Phe Lys Ala Ile Glu Phe Asp Tyr Leu Thr Asn Tyr Phe Ala
695 700 705AAC GAC AGA GTC AAC CAC AGA GGC TAT CTG CTA GGA ACA AGC CAT TTT 2217Asn Asp Arg Val Asn His Arg Gly Tyr Leu Leu Gly Thr Ser His Phe
710 715 720GAA AAG AGC GCT AAA GAA TGC GAA ACC ATA GAA TGC GAG CCT ATC AAG 2265Glu Lys Ser Ala Lys Glu Cys Glu Thr Ile Glu Cys Glu Pro Ile Lys
725 730 735CCT TTA AAA GAA AAA ATC GCT TTC AAC GCG TAT TTA AAA TAC CCA GAA 2313Pro Leu Lys Glu Lys Ile Ala Phe Asn Ala Tyr Leu Lys Tyr Pro Glu740 745 750 755ACG CAA TTC AAT AAC GCT ACT AAT AAA AGC GAG AAT TTG CAA TTA AAA 2361Thr Gln Phe Asn Asn Ala Thr Asn Lys Ser Glu Asn Leu Gln Leu Lys
760 765 770GCC GGT GTC TAT GTG TCT AAA GCT TTC TTA AAG AAA TTG AAT AAA GAA 2409Ala Gly Val Tyr Val Ser Lys Ala Phe Leu Lys Lys Leu Asn Lys Glu
775 780 785GTG GGG CAA AAC ATC ACT TTA TCT AAA GAA GAA GAG GAA TTA ACA GGC 2457Val Gly Gln Asn Ile Thr Leu Ser Lys Glu Glu Glu Glu Leu Thr Gly
790 795 800GTT TTG TAT CTT GAT GAG AGC TTG GAT CAG GAA GTG TTT GTT ATC TCG 2505Val Leu Tyr Leu Asp Glu Ser Leu Asp Gln Glu Val Phe Val Ile Ser
805 810 815CCT TCT CTT TTG AAA AAC CAT TCT GGC TTT TTT AGA GAG GGC GTG TTT 2553Pro Ser Leu Leu Lys Asn His Ser Gly Phe Phe Arg Glu Gly Val Phe820 825 830 835GAT AGC GTG GAT TTA AAG GAG CAA GCA TGAGCGCTTA TATCATTGAA ACCCTGA 2607Asp Ser Val Asp Leu Lys Glu Gln Ala
840TTAAAATTTT GATTTT 2623 (2) sequence 1042 data: (i) sequence characteristics: length (A): 844 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1042: met Ile Thr Met Asn Ile Asn Gly Lys Thr Ile Glu Cys Gln Glu Gly 151015 Gln Ser Val Leu Glu Ala Ala Arg Ser Ala Gly Ile Tyr Ile Pro Thr
20 25 30Ile Cys Tyr Leu Ser Gly Cys Ser Pro Thr Val Ala Cys Lys Met Cys
35 40 45Met Val Glu Met Asp Gly Lys Arg Val Tyr Ser Cys Asn Thr Lys Ala
50 55 60Lys Asn Asn Ala Thr Ile Leu Thr Asn Thr Pro Thr Leu Met Asp Glu65 70 75 80Arg Lys Ser Ile Met Gln Thr Tyr Asp Val Asn His Pro Leu Glu Cys
85 90 95Gly Val Cys Asp Lys Ser Gly Glu Cys Glu Leu Gln Asp Met Thr His
100 105 110Leu Thr Gly Val Glu His Gln Pro Tyr Ala Val Ala Asp Asp Phe Lys
115 120 125Ala Leu Asp Phe Trp Ala Lys Ala Leu Tyr Asp Pro Asn Leu Cys Ile
130 135 140Met Cys Glu Arg Cys Val Thr Thr Cys Lys Asp Asn Val Gly Glu Asn145 150 155 160Asn Leu Lys Ala Thr Lys Ala Asp Leu His Ala Pro Asp Lys Phe Lys
165 170 175Asp Ser Met Ser Lys Asp Ala Phe Ser Val Trp Ser Arg Lys Gln Lys
180 185 190Gly Ile Ile Ser Phe Val Gly Ser Val Pro Cys Tyr Asp Cys Gly Glu
195 200 205Cys Ile Ala Val Cys Pro Val Gly Ala Leu Ser Tyr Lys Asp Phe Ala
210 215 220Tyr Thr Ala Asn Ala Trp Glu Leu Lys Lys Ile His Ser Thr Cys Ser225 230 235 240His Cys Ser Ala Gly Cys Leu Ile Ser Tyr Asp Val Arg His Phe Asp
245 250 255Thr Leu Gly Glu Glu Ser Lys Ile Phe Arg Val Leu Asn Asp Phe Tyr
260 265 270His Asn Pro Ile Cys Gly Ala Gly Arg Phe Ala Phe Asp Val Ser Ser
275 280 285Ser Pro Lys Gly Ser Ala Asn Leu Lys Glu Ala Gln Asn Ala Leu Lys
290 295 300Glu Cys Glu Ala Val Arg Ile Gly Gly Asp Ile Thr Asn Glu Glu Ala305 310 315 320Phe Leu Ile Glu Arg Leu Arg Lys Glu Leu Asp Phe Lys Ile Tyr Asn
325 330 335Gln Glu Ala Tyr Arg Phe Gln Gln Phe Leu Lys Val Leu Gly Glu Ile
340 345 350Lys Arg Pro Ser Val Glu Glu Ile Lys Thr Ser His Leu Val Val Thr
355 360 365Ile Gly Ser Ser Ile Lys Thr Glu Asn Pro Leu Val Arg Tyr Ala Ile
370 375 380Asn Asn Ala Leu Lys Leu Asn Lys Ala Ser Leu Ile Ala Met His Pro385 390 395 400Ile Lys Asp Asn Ala Leu Ala Asn Leu Cys Arg Ser Ser Phe Cys Ile
405 410 415Thr His Glu Val Gly Ala Glu Glu Ile Leu Leu Gly Met Leu Leu Lys
420 425 430Met Leu Asn Ile Glu Ser Ala Ala Leu Lys Ser Leu Glu Asp Ser Lys
435 440 445Gln Asn Ile Val Asp Glu Ala Ala Leu Lys Ala Leu Glu Glu Glu Arg
450 455 460Lys Lys Ala Leu Glu Gln Ala Glu Gln Gly Cys Ser Ile Gly Glu Asn465 470 475 480Lys Ala Glu Asn Gln Glu Glu Asn Lys Thr Glu Ala Thr Thr Pro Lys
485 490 495Glu Glu Asn Gln Glu Glu Asn Lys Thr Glu Val Lys Glu Glu Lys Ile
500 505 510Glu Val Pro Thr Lys Thr Thr Tyr Leu Leu Leu Glu Glu Ala Gly Ile
515 520 525Asn Leu Glu Thr Tyr Glu Lys Ile Leu Ala Leu Leu Gln Lys Ser Asn
530 535 540Asn Thr Leu Leu Val Val Gly Glu Glu Ile Tyr Ser His Lys Gln Ala545 550 555 560His Asn Ile Ala Lys Met Leu Arg Leu Leu Ala Gln Lys Ser Ala Ile
565 570 575Lys Leu Ile Leu Ile Pro Pro Ser Ala Asn Ala Leu Gly Ile Ala Ser
580 585 590Ile Cys Gln Leu Ser Glu G1u Ile Phe Glu His Glu Lys Ile Val Gly
595 600 605Ile Arg Ala Gln Gly Asp Phe Thr Ile Asn Ser Asp Asp Arg Val Phe
610 615 620Gly Lys Asp Ala Ala Ser Lys Val Asp Phe Ile Leu Pro Ser Leu Asn625 630 635 640Gln Leu Glu Gly Thr Ile Thr Asn Ile Glu Gly Arg Val Leu Pro Leu
645 650 655Lys Pro Ala Leu Arg Phe Glu Gly Tyr Asp Leu Ser Asp Ile Met Gln
660 665 670Gly Phe Gly Phe Val Glu Glu Asn Leu lle Glu Cys Thr His Lys Leu
675 680 685Pro Thr Glu Ala Gly Phe Lys Ala Ile Glu Phe Asp Tyr Leu Thr Asn
690 695 700Tyr Phe Ala Asn Asp Arg Val Asn His Arg Gly Tyr Leu Leu Gly Thr705 710 715 720Ser His Phe Glu Lys Ser Ala Lys Glu Cys Glu Thr Ile Glu Cys Glu
725 730 735Pro Ile Lys Pro Leu Lys Glu Lys Ile Ala Phe Asn Ala Tyr Leu Lys
740 745 750Tyr Pro Glu Thr Gln Phe Asn Asn Ala Thr Asn Lys Ser Glu Asn Leu
755 760765Gln Leu Lys Ala Gly Val Tyr Val Ser Lys Ala Phe Leu Lys Lys Leu
770 775 780Asn Lys Glu Val Gly Gln Asn Ile Thr Leu Ser Lys Glu Glu Glu Glu785 790 795 800Leu Thr Gly Val Leu Tyr Leu Asp Glu Ser Leu Asp Gln Glu Val Phe
805 810 815Val Ile Ser Pro Ser Leu Leu Lys Asn His Ser Gly Phe Phe Arg Glu
820 825 830Gly Val Phe Asp Ser Val Asp Leu Lys Glu Gln Ala
835840 (2) data for sequence 1043: (i) sequence characteristics: length (A): 378bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 343 (D) other information: (xi) Description of the sequence: sequence 1043: AAATCCATGG GAAAAATCAC ACGCAATTTA TAAAGGAATC TCT ATG ATA GGG TTA 55
Met Ile Gly Leu
1AAC CAC TAT TTG ATT GTT TCA GGG TTG CTC TTT TGC ATT GGT TTA GCG 103Asn His Tyr Leu Ile Val Ser Gly Leu Leu Phe Cys Ile Gly Leu Ala 5 10 15 20GGC ATG CTG AAA CGC AAA AAC ATT CTG TTA CTC TTT TTT TCT ACA GAA 151Gly Met Leu Lys Arg Lys Asn Ile Leu Leu Leu Phe Phe Ser Thr Glu
25 30 35ATC ATG CTC AAT GCG ATC AAT ATC GGT TTT GTA GCG ATC TCT AAA TAC 199Ile Met Leu Asn Ala Ile Asn Ile Gly Phe Val Ala Ile Ser Lys Tyr
40 45 50ACG CAT AAT TTA GAC GGG CAG ATG TTT GCG CTC TTT ATT ATC TCT ATT 247Thr His Asn Leu Asp Gly Gln Met Phe Ala Leu Phe Ile Ile Ser Ile
55 60 65GCC GCT AGT GAG GTG GCT ATT GGT TTG GGC TTG GTG ATT TTG TGG TTT 295Ala Ala Ser Glu Val Ala Ile Gly Leu Gly Leu Val Ile Leu Trp Phe
707580 AAG AAA TTC AAA AGC TTA GAT ATT GAT TCT TTA AAC GCT ATG AAA GGT T344 Lys Lys Phe Lys Ser Leu Asp Ile Asp Ser Leu Asn Ala Met Lys Gly 859095100 GAGCATGCAA TATTCTTCTT TGCTGTCAGT GGTG 378 (2) sequence 1044 data: (i) sequence characteristics: length (A): 100 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1044: met Ile Gly Leu Asn His Tyr Leu Ile Val Ser Gly Leu Leu Phe Cys 151015 Ile Gly Leu Ala Gly Met Leu Lys Arg Lys Asn Ile Leu Leu Leu Phe
20 25 30Phe Ser Thr Glu Ile Met Leu Asn Ala Ile Asn Ile Gly Phe Val Ala
35 40 45Ile Ser Lys Tyr Thr His Asn Leu Asp Gly Gln Met Phe Ala Leu Phe
50 55 60Ile Ile Ser Ile Ala Ala Ser Glu Val Ala Ile Gly Leu Gly Leu Val65 70 75 80Ile Leu Trp Phe Lys Lys Phe Lys Ser Leu Asp Ile Asp Ser Leu Asn
85 90 95Ala Met Lys Gly
100 (2) data for sequence 1045: (i) sequence characteristics: length (A): 663bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 627 (D) other information: (xi) Description of the sequence: sequence 1045: CCGGTGGAAT AAGTC ATG CAA GCA GTG ATT TTA GCG AAT GGG GAG TTT CCT 51
Met Gln Ala Val Ile Leu Ala Asn Gly Glu Phe Pro
1 5 10AAA TCT CAA AAA TGC TTA GAC CTT TTA AAA AAC GCT CCC TTT TTA ATC 99Lys Ser Gln Lys Cys Leu Asp Leu Leu Lys Asn Ala Pro Phe Leu Ile
15 20 25GCA TGC GAT GGG GCT GTT ACC TCA TTA CAT GCG CTT CAA TTC AAA CCC 147Ala Cys Asp Gly Ala Val Thr Ser Leu His Ala Leu Gln Phe Lys Pro
30 35 40AGC GTT GTT ATA GGC GAT CTA GAT AGC ATT GAT TCG CAT TTG AAA GCT 195Ser Val Val Ile Gly Asp Leu Asp Ser Ile Asp Ser His Leu Lys Ala45 50 55 60TTG TAT AAC CCT ATA CGC ATG AGT GAA CAA AAC AGC AAC GAT TTG TCC 243Leu Tyr Asn Pro Ile Arg Met Ser Glu Gln Asn Ser Asn Asp Leu Ser
65 70 75AAA GCC TTT TTT TAT GCT TTA AAT AAA GGC TGT GAT GAC TTT ATT TTT 291Lys Ala Phe Phe Tyr Ala Leu Asn Lys Gly Cys Asp Asp Phe Ile Phe
80 85 90TTA GGG TTG AAT GGC AAG CGA GAA GAT CAC GCT TTA GCG AAC ACT TTT 339Leu Gly Leu Asn Gly Lys Arg Glu Asp His Ala Leu Ala Asn Thr Phe
95 100 105TTA TTG TTG GAA TAT TTT AAA TTT TGC CAA AAA ATC CAA GCC ATA AGC 387Leu Leu Leu Glu Tyr Phe Lys Phe Cys Gln Lys Ile Gln Ala Ile Ser
110 115 120GAC TAT GGT CTT TTT AGG GTG TTA GAA ACC CCT TTC ACT TTG CCC AGT 435Asp Tyr Gly Leu Phe Arg Val Leu Glu Thr Pro Phe Thr Leu Pro Ser125 130 135 140TTT AAA GGG GAA CAA ATC TCG CTT TTT AGC CTG GAT CTT AAA GCC CAA 483Phe Lys Gly Glu Gln Ile Ser Leu Phe Ser Leu Asp Leu Lys Ala Gln
145 150155TTC ACT TCT AAA AAC CTC AAA TAC CCC TTA AAA AAC TTG CGT TTA AAA 531Phe Thr Ser Lys Asn Leu Lys Tyr Pro Leu Lys Asn Leu Arg Leu Lys
160 165 170ACG CTC TTT TCT GGC TCG CTC AAT GAA GCT ACA GAT AGT TAT TTT AGC 579Thr Leu Phe Ser Gly Ser Leu Asn Glu Ala Thr Asp Ser Tyr Phe Ser
175 180 185CTT AGC TCT ACA CCT AAA TCG GTG GTG TTG GTG TAT CAA AAA TTC TTA T 628Leu Ser Ser Thr Pro Lys Ser Val Val Leu Val Tyr Gln Lys Phe Leu
190195200 AAGCGGGTTT TGTTAGGCAA GTTTTTGTCT GTATA 663 (2) data for sequence 1046: (i) sequence characteristics: length (A): 204 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1046: met Gln Ala Val Ile Leu Ala Asn Gly Glu Phe Pro Lys Ser Gln Lys 151015 Cys Leu Asp Leu Leu Lys Asn Ala Pro Phe Leu Ile Ala Cys Asp Gly
20 25 30Ala Val Thr Ser Leu His Ala Leu Gln Phe Lys Pro Ser Val Val Ile
35 40 45Gly Asp Leu Asp Ser Ile Asp Ser His Leu Lys Ala Leu Tyr Asn Pro
50 55 60Ile Arg Met Ser Glu Gln Asn Ser Asn Asp Leu Ser Lys Ala Phe Phe65 70 75 80Tyr Ala Leu Asn Lys Gly Cys Asp Asp Phe Ile Phe Leu Gly Leu Asn
85 90 95Gly Lys Arg Glu Asp His Ala Leu Ala Asn Thr Phe Leu Leu Leu Glu
100 105 110Tyr Phe Lys Phe Cys Gln Lys Ile Gln Ala Ile Ser Asp Tyr Gly Leu
115 120 125Phe Arg Val Leu Glu Thr Pro Phe Thr Leu Pro Ser Phe Lys Gly Glu
130 135 140Gln Ile Ser Leu Phe Ser Leu Asp Leu Lys Ala Gln Phe Thr Ser Lys145 150 155 160Asn Leu Lys Tyr Pro Leu Lys Asn Leu Arg Leu Lys Thr Leu Phe Ser
165 170 175Gly Ser Leu Asn Glu Ala Thr Asp Ser Tyr Phe Ser Leu Ser Ser Thr
180 185 190Pro Lys Ser Val Val Leu Val Tyr Gln Lys Phe Leu
195200 (2) data for sequence 1047: (i) sequence characteristics: length (A): 1106bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (II) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1048 (D) other information: (xi) Description of the sequence: sequence 1047: AGTAAGGGGT TAGAGC ATG AAA GTT ATC AAA ACA GCA CCT TTG ATC CCA TCA 52
Met Lys Val Ile Lys Thr Ala Pro Leu Ile Pro Ser
1 5 10GAA ATT AAG GTG CTA GAG AAA GAG GGC AAT CGG GTT AAG ATT TCT CTG 100Glu Ile Lys Val Leu Glu Lys Glu Gly Asn Arg Val Lys Tle Ser Leu
15 20 25GCT CCA TTT GAG TTT GGT TAC GCT GTT ACG CTC GCT CAT CCT ATT AGA 148Ala Pro Phe Glu Phe Gly Tyr Ala Val Thr Leu Ala His Pro Ile Arg
30 35 40AGG CTC TTG CTT TTA AGC TCT GTG GGG TAT GCT CCT GTA GGT TTA AAG 196Arg Leu Leu Leu Leu Ser Ser Val Gly Tyr Ala Pro Val Gly Leu Lys45 50 55 60ATT GAA GGC GTC CAT CAT GAG TTT GAC TCT TTA AGG GGG GTT ACT GAA 244Ile Glu Gly Val His His Glu Phe Asp Ser Leu Arg Gly Val Thr Glu
65 70 75GAC GTG TCG CTT TTT ATC ATG AAT TTA AAA AAT ATC CGC TTT ATA GCC 292Asp Val Ser Leu Phe Ile Met Asn Leu Lys Asn Ile Arg Phe Ile Ala
80 85 90AAG GCG TTA GTG GGG CAG GAT AGC TCT TTA GAA AAC CAA TCG GTT GTG 340Lys Ala Leu Val Gly Gln Asp Ser Ser Leu Glu Asn Gln Ser Val Val
95 100 105GTG GAT TAT TCT TTT AAA GGG CCT ATG GAG CTT AGG GCT AGG GAT TTG 388Val Asp Tyr Ser Phe Lys Gly Pro Met Glu Leu Arg Ala Arg Asp Leu
110 115 120AAT TCT GAG CAG ATA GAA ATC GTC AAT CCG GAA ATG CCC CTA GCG ACA 436Asn Ser Glu Gln Ile Glu Ile Val Asn Pro Glu Met Pro Leu Ala Thr125 130 135 140ATC AAT GAA GAC GCT CAA TTG AAT TTT TCG CTC ATT ATT TAT AAA GGA 484Ile Asn Glu Asp Ala Gln Leu Asn Phe Ser Leu Ile Ile Tyr Lys Gly
145 150 155ATG GGG TAT GTC CCA AGC GAA AAC ACA AGG GAA TTG ATG CCT GAG GGC 532Met Gly Tyr Val Pro Ser Glu Asn Thr Arg Glu Leu Met Pro Glu Gly
160 165 170TAC ATG CCG CTA GAC GGC TCT TTC ACG CCG ATT AAA AAG GTC GTT TAT 580Tyr Met Pro Leu Asp Gly Ser Phe Thr Pro Ile Lys Lys Val Val Tyr
175 180 185GAG ATT GAA AAC GTT CTG GTT GAG GGC GAT CCC AAC TAT GAA AAA ATC 628Glu Ile Glu Asn Val Leu Val Glu Gly Asp Pro Asn Tyr Glu Lys Ile
190 195 200ATT TTT GAT ATT GAA ACA GAC GGG CAG ATT GAC CCT TAT AAA GCG TTT 676Ile Phe Asp Ile Glu Thr Asp Gly Gln Ile Asp Pro Tyr Lys Ala Phe205 210 215 220TTA TCA GCG GTG AAA GTG ATG AGC AAG CAATTG GGT GTT TTT GGC GAA 724Leu Ser Ala Val Lys Val Met Ser Lys Gln Leu Gly Val Phe Gly Glu
225 230 235AGA CCC ATT GCT AAC ACG GAG TAT TCA GGC GAT TAC GCT CAA AGA GAT 772Arg Pro Ile Ala Asn Thr Glu Tyr Ser Gly Asp Tyr Ala Gln Arg Asp
240 245 250GAC GCT AAA GAC TTG AGC GCT AAG ATT GAA AGC ATG AAT TTG AGC GCT 820Asp Ala Lys Asp Leu Ser Ala Lys Ile Glu Ser Met Asn Leu Ser Ala
255 260 265AGG TGT TTT AAT TGC TTG GAT AAA ATC GGC ATC AAG TAT GTG GGC GAA 868Arg Cys Phe Asn Cys Leu Asp Lys Ile Gly Ile Lys Tyr Val Gly Glu
270 275 280CTC GTG TTG ATG AGC GAA GAA GAG CTT AAG GGC GTG AAA AAC ATG GGT 916Leu Val Leu Met Ser Glu Glu Glu Leu Lys Gly Val Lys Asn Met Gly285 290 295 300AAA AAA TCC TAT GAT GAA ATC GCT GAA AAA TTG AAT GAT TTG GGC TAT 964Lys Lys Ser Tyr Asp Glu Ile Ala Glu Lys Leu Asn Asp Leu Gly Tyr
305 310 315CCG GTA GGC ACA GAA TTA AGC CCT GAA CAA AGA GAG AGT TTA AAG AAA 1012Pro Val Gly Thr Glu Leu Ser Pro Glu Gln Arg Glu Ser Leu Lys Lys
320 325 330AGA TTA GAA AAA TTA GAA GAT AAA GGA GGT AAC GAC TGATGAGACA CAAACA 1064Arg Leu Glu Lys Leu Glu Asp Lys Gly Gly Asn Asp
335340 CGGATACCGC AAGCTTGGGA GAACCAGCTC GCACAGAAAG GC 1106 (2) sequence 1048 data: (i) sequence characteristics: length (A): 344 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1048: met Lys Val Ile Lys Thr Ala Pro Leu Ile Pro Ser Glu Ile Lys Val 151015 Leu Glu Lys Glu Gly Asn Arg Val Lys Ile Ser Leu Ala Pro Phe Glu
20 25 30Phe Gly Tyr Ala Val Thr Leu Ala His Pro Ile Arg Arg Leu Leu Leu
35 40 45Leu Ser Ser Val Gly Tyr Ala Pro Val Gly Leu Lys Ile Glu Gly Val
50 55 60His His Glu Phe Asp Ser Leu Arg Gly Val Thr Glu Asp Val Ser Leu65 70 75 80Phe Ile Met Asn Leu Lys Asn Ile Arg Phe Ile Ala Lys Ala Leu Val
85 90 95Gly Gln Asp Ser Ser Leu Glu Asn Gln Ser Val Val Val Asp Tyr Ser
100 105 110Phe Lys Gly Pro Met Glu Leu Arg Ala Arg Asp Leu Asn Ser Glu Gln
115 120 125Ile Glu Ile Val Asn Pro Glu Met Pro Leu Ala Thr Ile Asn Glu Asp
130 135 140Ala Gln Leu Asn Phe Ser Leu Ile Ile Tyr Lys Gly Met Gly Tyr Val145 150 155 160Pro Ser Glu Asn Thr Arg Glu Leu Met Pro Glu Gly Tyr Met Pro Leu
165 170 175Asp Gly Ser Phe Thr Pro Ile Lys Lys Val Val Tyr Glu Ile Glu Asn
180 185 190Val Leu Val Glu Gly Asp Pro Asn Tyr Glu Lys Ile Ile Phe Asp Ile
195 200 205Glu Thr Asp Gly Gln Ile Asp Pro Tyr Lys Ala Phe Leu Ser Ala Val
210 215 220Lys Val Met Ser Lys Gln Leu Gly Val Phe Gly Glu Arg Pro Ile Ala225 230 235 240Asn Thr Glu Tyr Ser Gly Asp TyrAla Gln Arg Asp Asp Ala Lys Asp
245 250 255Leu Ser Ala Lys Ile Glu Ser Met Asn Leu Ser Ala Arg Cys Phe Asn
260 265 270Cys Leu Asp Lys Ile Gly Ile Lys Tyr Val Gly Glu Leu Val Leu Met
275 280 285Ser Glu Glu Glu Leu Lys Gly Val Lys Asn Met Gly Lys Lys Ser Tyr
290 295 300Asp Glu Ile Ala Glu Lys Leu Asn Asp Leu Gly Tyr Pro Val Gly Thr305 310 315 320Glu Leu Ser Pro Glu Gln Arg Glu Ser Leu Lys Lys Arg Leu Glu Lys
325 330 335Leu Glu Asp Lys Gly Gly Asn Asp
340 (2) data for sequence 1049: (i) sequence characteristics: length (A): 423bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 375 (D) other information: (xi) Description of the sequence: sequence 1049: AGACAAGGAT AAAGC ATG GCA AGG ATT GCT GGT GTA GAT TTA CCA AAA AAG 51
Met Ala Arg Ile Ala Gly Val Asp Leu Pro Lys Lys
1 5 10AAG AGA GTG GAG TAT GCC CTT ACC TAT ATT TAT GGG ATT GGG CTT AAG 99Lys Arg Val Glu Tyr Ala Leu Thr Tyr Ile Tyr Gly Ile Gly Leu Lys
15 20 25AGT TCC AGA GAG ATT TTA GAA GCG GTA GGC ATT TCT TTT GAC AAG CGC 147Ser Ser Arg Glu Ile Leu Glu Ala Val Gly Ile Ser Phe Asp Lys Arg
30 35 40GTG CAT GAA TTG AGC GAA GAT GAA GTG TCT AGC ATC GCT AAA AAA ATC 195Val HisGlu Leu Ser Glu Asp Glu Val Ser Ser Ile Ala Lys Lys Ile45 50 55 60CAA CAA AGC TAC CTA GTA GAG GGC GAT TTG CGT AAA AAA GTT CAA ATG 243Gln Gln Ser Tyr Leu Val Glu Gly Asp Leu Arg Lys Lys Val Gln Met
65 70 75GAT ATT AAA TCT TTA ATG GAC TTG GGG AAT TAT CGT GGG ATC AGG CAT 291Asp Ile Lys Ser Leu Met Asp Leu Gly Asn Tyr Arg Gly Ile Arg His
80 85 90CGT AAG GGT CTT CCT GTG AGA GGT CAA ACC ACT AAA AAT AAC GCT AGG 339Arg Lys Gly Leu Pro Val Arg Gly Gln Thr Thr Lys Asn Asn Ala Arg
95 100 105ACT CGT AAG GGT AAG AAA AAA ACC GTG GGT AGC AAG TAGCGAATAA GGAGAT 391Thr Arg Lys Gly Lys Lys Lys Thr Val Gly Ser Lys
110115120 GATGATTTAA TGGCTAAGAG AAATGTAACG GC 423 (423) (2) sequence 1050 data: (i) sequence characteristics: length (A): 120 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1050: met Ala Arg Ile Ala Gly Val Asp Leu Pro Lys Lys Lys Arg Val Glu 151015 Tyr Ala Leu Thr Tyr Ile Tyr Gly Ile Gly Leu Lys Ser Ser Arg Glu
20 25 30Ile Leu Glu Ala Val Gly Ile Ser Phe Asp Lys Arg Val His Glu Leu
35 40 45Ser Glu Asp Glu Val Ser Ser Ile Ala Lys Lys Ile Gln Gln Ser Tyr
50 55 60Leu Val Glu Gly Asp Leu Arg Lys Lys Val Gln Met Asp Ile Lys Ser65 70 75 80Leu Met Asp Leu Gly Asn Tyr Arg Gly Ile Arg His Arg Lys Gly Leu
85 90 95Pro Val Arg GlyGln Thr Thr Lys Asn Asn Ala Arg Thr Arg Lys Gly
100 105 110Lys Lys Lys Thr Val Gly Ser Lys
115120 (2) sequence 1051 data: (i) sequence characteristics: length (A): 649bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 621 (D) other information: (xi) Description of the sequence: sequence 1051: AAGCGTAGGG TGTTTTTA ATG ATT TTT TAT AGA AAG GAA GCT ACA ATG AAC 51
Met Ile Phe Tyr Arg Lys Glu Ala Thr Met Asn
1 5 10GCA TTG AAA AAA TTA AGT TTC TGC GCC TTG TTA TCC CTA GGC CTC TTC 99Ala Leu Lys Lys Leu Ser Phe Cys Ala Leu Leu Ser Leu Gly Leu Phe
15 20 25GCT CAA ACA GCG CAT GCT AAG CAT TTA AAG GGC ACG ATT AAC TAT CCT 147Ala Gln Thr Ala His Ala Lys His Leu Lys Gly Thr Ile Asn Tyr Pro
30 35 40GAT TGG CTT GAA ATC AAT TTT TTT GAC GAA AAA AAC CCG CCC AAT CAA 195Asp Trp Leu Glu Ile Asn Phe Phe Asp Glu Lys Asn Pro Pro Asn Gln
45 50 55TAT GTC GGA TCG GCT TCA ATT TCT GGT AAA AGG AAC GAT TTT TAC GCC 243Tyr Val Gly Ser Ala Ser Ile Ser Gly Lys Arg Asn Asp Phe Tyr Ala60 65 70 75AAT TAC ATC CCC TAT GAT GAC CAA TTG CCC CCT GAA CAA AAC GCT GAA 291Asn Tyr Ile Pro Tyr Asp Asp Gln Leu Pro Pro Glu Gln Asn Ala Glu
80 85 90AAA ATC GCT CTT TTA AGG GCC AGA ATA AAC GCT TAC AGC ACT TTA GAG 339Lys Ile Ala Leu Leu Arg Ala Arg Ile Asn Ala Tyr Ser Thr Leu Glu
95 100 105AGC ATT TTA CTC ACT AAA ATG CAC AAT CGT ATT GTT AAG GTG CTT CAA 387Ser Ile Leu Leu Thr Lys Met His Asn Arg Ile Val Lys Val Leu Gln
110 115 120GTT AAA AAT AAT GTT ATC AGC CAT TTA TTC GGG CTT GTT GAT TTT TTA 435Val Lys Asn Asn Val Ile Ser His Leu Phe Gly Leu Val Asp Phe Leu
125 130 135ACC TCT AAA TCC ATT TTG GCT AAA AGG TTC GTG GAT ACC ACA AAT CAT 483Thr Ser Lys Ser Ile Leu Ala Lys Arg Phe Val Asp Thr Thr Asn His140 145 150 155CGT GTG TAT GTC ATG GTG CAA TTC CCT TTC ATT CAG CCT GAA GAC TTG 531Arg Val Tyr Val Met Val Gln Phe Pro Phe Ile Gln Pro Glu Asp Leu
160 165 170ATC GCT TAC TTT AAA GCC AAA CGC ATC GAC CTT TCT TCA GCG AGC GCT 579Ile Ala Tyr Phe Lys Ala Lys Arg Ile Asp Leu Ser Ser Ala Ser Ala
175 180 185ACC CAT CTC AGC GCC CTT TTA AAT AAG GCG TTG TTC CAC CTC TAAGAGTTT 630Thr His Leu Ser Ala Leu Leu Asn Lys Ala Leu Phe His Leu
190195200 GGGATTTAAG ATGCGGTTT 649 (2) sequence 1052 data: (i) sequence characteristics: length (A): 201 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1052: met Ile Phe Tyr Arg Lys Glu Ala Thr Met Asn Ala Leu Lys Lys Leu 151015 Ser Phe Cys Ala Leu Leu Ser Leu Gly Leu Phe Ala Gln Thr Ala His
20 25 30Ala Lys His Leu Lys Gly Thr Ile Asn Tyr Pro Asp Trp Leu Glu Ile
35 40 45Asn Phe Phe Asp Glu Lys Asn Pro Pro Asn Gln Tyr Val Gly Ser Ala
50 55 60Ser Ile Ser Gly Lys Arg Asn Asp Phe Tyr Ala Asn Tyr Ile Pro Tyr65 70 75 80Asp Asp Gln Leu Pro Pro Glu Gln Asn Ala Glu Lys Ile Ala Leu Leu
85 90 95Arg Ala Arg Ile Asn Ala Tyr Ser Thr Leu Glu Ser Ile Leu Leu Thr
100 105 110Lys Met His Asn Arg Ile Val Lys Val Leu Gln Val Lys Asn Asn Val
115 120 125Ile Ser His Leu Phe Gly Leu Val Asp Phe Leu Thr Ser Lys Ser Ile
130 135 140Leu Ala Lys Arg Phe Val Asp Thr Thr Asn His Arg Val Tyr Val Met145 150 155 160Val Gln Phe Pro Phe Ile Gln Pro Glu Asp Leu Ile Ala Tyr Phe Lys
165 170 175Ala Lys Arg Ile Asp Leu Ser Ser Ala Ser Ala Thr His Leu Ser Ala
180 185 190Leu Leu Asn Lys Ala Leu Phe His Leu
195200 (2) sequence 1053 data: (i) sequence characteristics: length (A): 540bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 513 (D) other information: (xi) Description of the sequence: sequence 1053: GCATGCTCTT AGAGT ATG TCT GTA TCG CAT GTT GCT TTA ATC TTA AGG AAA 51
Met Ser Val Ser His Val Ala Leu Ile Leu Arg Lys
1 5 10TTG TTT TAT CAT AGA CAA GGA GTT TTT ATG GGC GGT TTT TCA GTG GGA 99Leu Phe Tyr His Arg Gln Gly Val Phe Met Gly Gly Phe Ser Val Gly
15 20 25ATG TTG AAA GAT TAT GTG GAC ATA TTT GTT TTT GCG GTG CTT GGC GTG 147Met Leu Lys Asp Tyr Val Asp Ile Phe Val Phe Ala Val Leu Gly Val
30 35 40GCC AGT TTT TTA GCT TTG TGG TTT GCG ATT GAA AGG GTT ATT TTT TAT 195Ala Ser Phe Leu Ala Leu Trp Phe Ala Ile Glu Arg Val Ile Phe Tyr45 50 55 60TCT AAA GTC GAT TTG AAA GCT TAT GAC GAT ATA GAT GCC CTG AAT TTG 243Ser Lys Val Asp Leu Lys Ala Tyr Asp Asp Ile Asp Ala Leu Asn Leu
65 70 75GAT TTA ACC AAG AAT CTA ACC ATT CTC TAT GTG ATT TTT TCT AAC GCG 291Asp Leu Thr Lys Asn Leu Thr Ile Leu Tyr Val Ile Phe Ser Asn Ala
80 85 90CCT TAT GTG GGC TTA TTA GGG ACG GTT TTA GGG ATT ATG GTG ATT TTC 339Pro Tyr Val Gly Leu Leu Gly Thr Val Leu Gly Ile Met Val Ile Phe
95 100 105TAT GAC ATG GGC GTG AGC GGC GGG ATG GAC GCT AAA ACG ATC ATG GTA 387Tyr Asp Met Gly Val Ser Gly Gly Met Asp Ala Lys Thr Ile Met Val
110 115 120GGT TTG TCT TTG GCT TTA AAA GCG ACC GCT CTA GGG CTT GCT GTG GCG 435Gly Leu Ser Leu Ala Leu Lys Ala Thr Ala Leu Gly Leu Ala Val Ala125 130 135 140ATT CCC ACT TTG ATC GCT TAT AAT AGC TTG TTG AGA AAA TCC GAT GTT 483Ile Pro Thr Leu Ile Ala Tyr Asn Ser Leu Leu Arg Lys Ser Asp Val
145 150 155TTG AGC GAA AAA TTC AGG ATC ATG AAA AAA TGAAAAGCAT CAGAAGAGGC GAT 536Leu Ser Glu Lys Phe Arg Ile Met Lys Lys
160165 GGGC 540 (2) sequence 1054 data: (i) sequence characteristics: length (A): 166amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1054: met Ser Val Ser His Val Ala Leu Ile Leu Arg Lys Leu Phe Tyr His 151015 Arg Gln Gly Val Phe Met Gly Gly Phe Ser Val Gly Met Leu Lys Asp
20 25 30Tyr Val Asp Ile Phe Val Phe Ala Val Leu Gly Val Ala Ser Phe Leu
35 40 45Ala Leu Trp Phe Ala Ile Glu Arg Val Ile Phe Tyr Ser Lys Val Asp
50 55 60Leu Lys Ala Tyr Asp Asp Ile Asp Ala Leu Asn Leu Asp Leu Thr Lys65 70 75 80Asn Leu Thr Ile Leu Tyr Val Ile Phe Ser Asn Ala Pro Tyr Val Gly
85 90 95Leu Leu Gly Thr Val Leu Gly Ile Met Val Ile Phe Tyr Asp Met Gly
100 105 110Val Ser Gly Gly Met Asp Ala Lys Thr Ile Met Val Gly Leu Ser Leu
115 120 125Ala Leu Lys Ala Thr Ala Leu Gly Leu Ala Val Ala Ile Pro Thr Leu
130 135 140Ile Ala Tyr Asn Ser Leu Leu Arg Lys Ser Asp Val Leu Ser Glu Lys145 150 155 160Phe Arg Ile Met Lys Lys
165 (2) sequence 1055 data: (i) sequence characteristics: length (A): 777bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 723 (D) other information: (xi) Description of the sequence: sequence 1055: TCATGAATTA AACCCTAGCG AACA ATG AAG CTT TTT GAC TAC GCT CCT TTG 51
Met Lys Leu Phe Asp Tyr Ala Pro Leu
1 5AGT TTG GCT TGG CGG GAG TTT TTG CAA AGC GAA TTT AAA AAG CCT TAT 99Ser Leu Ala Trp Arg Glu Phe Leu Gln Ser Glu Phe Lys Lys Pro Tyr10 15 20 25TTT TTA GAA ATA GAA AAA CGC TAC CTA GAA GCC CTA AAA ATC CCT AAA 147Phe Leu Glu Ile Glu Lys Arg Tyr Leu Glu Ala Leu Lys Ile Pro Lys
30 35 40ACC ATT TTC CCT AAA AGC TCT AAT CTG TTT TAT GCG CTC AAT CTA ACG 195Thr Ile Phe Pro Lys Ser Ser Asn Leu Phe Tyr Ala Leu Asn Leu Thr
45 50 55CCC CCT TGT GCG GTT AAA ATC ATC CTT TTA GGG CAA GAC CCC TAC CAT 243Pro Pro Cys Ala Val Lys Ile Ile Leu Leu Gly Gln Asp Pro Tyr His
60 65 70TCC ACC TAC CTA GAA AAT GAT CAA GAA TTG CCG GTG GCG ATG GGG TTG 291Ser Thr Tyr Leu Glu Asn Asp Gln Glu Leu Pro Val Ala Met Gly Leu
75 80 85AGC TTT AGC GTG GAA AAA AAC GCC CCT ATT CCT CCA AGT TTA AAA AAT 339Ser Phe Ser Val Glu Lys Asn Ala Pro Ile Pro Pro Ser Leu Lys Asn90 95 100 105ATT TTT AAA GAA TTG CAT GCG AAT TTA GGC GTG CCT GTG CCT TGT TGT 387Ile Phe Lys Glu Leu His Ala Asn Leu Gly Val Pro Val Pro Cys Cys
110 115 120GGG GAT TTG AGC GCA TGG GCT AAA AGG GGC ATG CTC TTA TTG AAC GCC 435Gly Asp Leu Ser Ala Trp Ala Lys Arg Gly Met Leu Leu Leu Asn Ala
125 130 135ATT TTA AGC GTG GAA AAA AAC CAA GCC GCT TCG CAC CAA TAT ATT GGC 483Ile Leu Ser Val Glu Lys Asn Gln Ala Ala Ser His Gln Tyr Ile Gly
140145 150TGG GAA GCT TTT AGC GAT CAA ATA CTG ATG CGC CTT TTT GAA ACG ACC 531Trp Glu Ala Phe Ser Asp Gln Ile Leu Met Arg Leu Phe Glu Thr Thr
155 160 165GCC CCT TTA ATC GTG GTG TTA CTA GGG AAA GTC GCC CAA AAA AAG ATC 579Ala Pro Leu Ile Val Val Leu Leu Gly Lys Val Ala Gln Lys Lys Ile170 175 180 185GCG TTA ATC CCC AAA AAC AAA CAC ATC ATC ATC ACA GCC CCT CAC CCT 627Ala Leu Ile Pro Lys Asn Lys His Ile Ile Ile Thr Ala Pro His Pro
190 195 200AGC CCA CTA TCT AGG GGG TTT TTA GGG AGT GGG GTT TTT ACA AGC GTT 675Ser Pro Leu Ser Arg Gly Phe Leu Gly Ser Gly Val Phe Thr Ser Val
205 210 215CAA AAA GCT TAT AGA GAG GTT TAT CGC AAG GAT TTT GAT TTT AGT TTA T 724Gln Lys Ala Tyr Arg Glu Val Tyr Arg Lys Asp Phe Asp Phe Ser Leu
220225230 GATTGATGCT TAATGAGACA GAACCCCTTA AGAATGCCTT TATTTAAGAG CAT 777(2) SEQ ID NO: (i) sequence characteristics: length (A): 233 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1056: met Lys Leu Phe Asp Tyr Ala Pro Leu Ser Leu Ala Trp Arg Glu Phe 151015 Leu Gln Ser Glu Phe Lys Lys Pro Tyr Phe Leu Glu Ile Glu Lys Arg
20 25 30Tyr Leu Glu Ala Leu Lys Ile Pro Lys Thr Ile Phe Pro Lys Ser Ser
35 40 45Asn Leu Phe Tyr Ala Leu Asn Leu Thr Pro Pro Cys Ala Val Lys Ile
50 55 60Ile Leu Leu Gly Gln Asp Pro Tyr His Ser Thr Tyr Leu Glu Asn Asp65 70 75 80Gln Glu Leu Pro Val Ala Met Gly Leu Ser Phe Ser Val Glu Lys Asn
85 90 95Ala Pro Ile Pro Pro Ser Leu Lys Asn Ile Phe Lys Glu Leu His Ala
100 105 110Asn Leu Gly Val Pro Val Pro Cys Cys Gly Asp Leu Ser Ala Trp Ala
115 120 125Lys Arg Gly Met Leu Leu Leu Asn Ala Ile Leu Ser Val Glu Lys Asn
130 135 140Gln Ala Ala Ser His Gln Tyr Ile Gly Trp Glu Ala Phe Ser Asp Gln145 150 155 160Ile Leu Met Arg Leu Phe Glu Thr Thr Ala Pro Leu Ile Val Val Leu
165 170 175Leu Gly Lys Val Ala Gln Lys Lys Ile Ala Leu Ile Pro Lys Asn Lys
180 185 190His Ile Ile Ile Thr Ala Pro His Pro Ser Pro Leu Ser Arg Gly Phe
195 200 205Leu Gly Ser Gly Val Phe Thr Ser Val Gln Lys Ala Tyr Arg Glu Val
210 215 220Tyr Arg Lys Asp Phe Asp Phe Ser Leu225 230
(2) Data for sequence 1057: (i) sequence characteristics: length (A): 1242bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1179 (D) other information: (xi) Description of the sequence: sequence 1057: AAGAAGAAAT AAAAACTC ATG GGG TTT TTA TTT GAA AAA TCG TTA ATG AGT 51
Met Gly Phe Leu Phe Glu Lys Ser Leu Met Ser
1 5 10TTT TTC GCT CAT CCA ATC AAA ATC CTT AAA ATC ATC AGTTTG ATT TTA 99Phe Phe Ala His Pro Ile Lys Ile Leu Lys Ile Ile Ser Leu Ile Leu
15 20 25AGT TTT TTG GTA AGC TTT TTG GTT GCT GAA AAC GCT CAT GAG CCA GAA 147Ser Phe Leu Val Ser Phe Leu Val Ala Glu Asn Ala His Glu Pro Glu
30 35 40GAA ATC AAG GCT AAA GTG GCT TAT GTG AAA ATC CCC CAA TTA GAA GAT 195Glu Ile Lys Ala Lys Val Ala Tyr Val Lys Ile Pro Gln Leu Glu Asp
45 50 55TTG GAA AAC AAC CCG GTT TAT ATC GGT CAA ATT ATA GGC GTA ACT TAT 243Leu Glu Asn Asn Pro Val Tyr Ile Gly Gln Ile Ile Gly Val Thr Tyr60 65 70 75GAT TTA TTG CTG TTT GAC GCT GAG TTT TTG GAA GCC AAA ATC AAA GAC 291Asp Leu Leu Leu Phe Asp Ala Glu Phe Leu Glu Ala Lys Ile Lys Asp
80 85 90GGG TTG GAT AAA ACC CAA ATT GAG CTT TTA AAC AAG ATG CCT AAA TGG 339Gly Leu Asp Lys Thr Gln Ile Glu Leu Leu Asn Lys Met Pro Lys Trp
95 100 105AAA AAG GTG GAA AAA GAG CTT TTC AGA GCG ACT TAT TAT TAC AAG ATT 387Lys Lys Val Glu Lys Glu Leu Phe Arg Ala Thr Tyr Tyr Tyr Lys Ile
110 115 120AAG GGC ATA AAA GCG ATT ATT CCG TCC TTA GAA GTG AGC GCG TTT TCC 435Lys Gly Ile Lys Ala Ile Ile Pro Ser Leu Glu Val Ser Ala Phe Ser
125 130 135AAT AAA GAC AAA TAC ATA GAT CAT TCC ATA GCC CCA AAA GTT ACT TTG 483Asn Lys Asp Lys Tyr Ile Asp His Ser Ile Ala Pro Lys Val Thr Leu140 145 150 155CAG GTA ACG GAT TTG TCC AAA AAC CCT CGT TAT GCG AAT GTC ATG GCT 531Gln Val Thr Asp Leu Ser Lys Asn Pro Arg Tyr Ala Asn Val Met Ala
160 165 170AAA GAT TTA CAA GTC TTG CAA TAC AAA ACC AAA GAT TAT GAC GAT AAA 579Lys Asp Leu Gln Val Leu Gln Tyr Lys Thr Lys Asp Tyr Asp Asp Lys
175 180 185AAC AAT ATT TTG GTG ATG GAA ATA GCG TTC AAA GAA GCC ACT TGG GAA 627Asn Asn Ile Leu Val Met Glu Ile Ala Phe Lys Glu Ala Thr Trp Glu
190 195 200GAT TTT CAC ATC AAA GAA GCG ATC AAG CAA GGG TTT GAT AAC GCC TCT 675Asp Phe His Ile Lys Glu Ala Ile Lys Gln Gly Phe Asp Asn Ala Ser
205 210 215TTA AAC CAG ATC AAG GCT AAA GAA GGG AGC GTT TTT TAT TAT TGC GTG 723Leu Asn Gln Ile Lys Ala Lys Glu Gly Ser Val Phe Tyr Tyr Cys Val220 225 230 235TTG CCT AAG ACT ATT CAA AAC CTT TCT TTT GAT TAT TTC TCG CTT TCA 771Leu Pro Lys Thr Ile Gln Asn Leu Ser Phe Asp Tyr Phe Ser Leu Ser
240 245 250AAT AAG CAA TTT AAA ACC TTA TCT TTT TCA ACC ATT CCC ACT CAA GAC 819Asn Lys Gln Phe Lys Thr Leu Ser Phe Ser Thr Ile Pro Thr Gln Asp
255 260 265ACT ACC GGT ATT CAA AGC GAT CTC ATC CCT AAA AAC AAT TTT TTA GTC 867Thr Thr Gly Ile Gln Ser Asp Leu Ile Pro Lys Asn Asn Phe Leu Val
270 275 280TTT TCT AAT GTG GCG TTG CTC GCT TTG TGC GTG TTT TTC TTG GTG CTG 915Phe Ser Asn Val Ala Leu Leu Ala Leu Cys Val Phe Phe Leu Val Leu
285 290 295TTT TTC ATT TTT GGG CGC AAA CTC ATT TTT TTA GGG CTT GGG ATT TTG 963Phe Phe Ile Phe Gly Arg Lys Leu Ile Phe Leu Gly Leu Gly Ile Leu300 305 310 315TGCTTA GGG TTT GTT TTG TAT CAC CTT TTA TTC ACG CAA AAA TCA GCC 1011Cys Leu Gly Phe Val Leu Tyr His Leu Leu Phe Thr Gln Lys Ser Ala
320 325 330CTA TTG CTC GCT CAT AAA AAA ATC CGC ATT CTG CCC ACG CAA AAT TCC 1059Leu Leu Leu Ala His Lys Lys Ile Arg Ile Leu Pro Thr Gln Asn Ser
335 340 345ACC ATT TTA GGG CTT TCT AAA AAT GAA ATG CCG ATT AAA ATC TTA GGC 1107Thr Ile Leu Gly Leu Ser Lys Asn Glu Met Pro Ile Lys Ile Leu Gly
350 355 360TCG CAT GAT GAT TAT TAT AAA ATC CTA ACG CCG CAT GAA CAA ATA GGA 1155Ser His Asp Asp Tyr Tyr Lys Ile Leu Thr Pro His Glu Gln Ile Gly
365370375 TGG GTC AAA AAA GAT GAA GTC AAA TAAAAAGTCC AATCGTTTAA GAGCGATTTA 1209Trp Val Lys Lys Asp Glu Val Lys 380385 TAGAGCTTTTA GTGATCGCTA TAGGACTAGC TGT 1242 (2) sequence 1058 data: (i) sequence characteristics: length (A): 387 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1058: met Gly Phe Leu Phe Glu Lys Ser Leu Met Ser Phe Phe Ala His Pro 151015 Ile Lys Ile Leu Lys Ile Ile Ser Leu Ile Leu Ser Phe Leu Val Ser
20 25 30Phe Leu Val Ala Glu Asn Ala His Glu Pro Glu Glu Ile Lys Ala Lys
35 40 45Val Ala Tyr Val Lys Ile Pro Gln Leu Glu Asp Leu Glu Asn Asn Pro
50 55 60Val Tyr Ile Gly Gln Ile Ile Gly Val Thr Tyr Asp Leu Leu Leu Phe65 70 75 80Asp Ala Glu Phe Leu Glu Ala Lys Ile Lys Asp Gly Leu Asp Lys Thr
85 90 95Gln Ile Glu Leu Leu Asn Lys Met Pro Lys Trp Lys Lys Val Glu Lys
100 105 110Glu Leu Phe Arg Ala Thr Tyr Tyr Tyr Lys Ile Lys Gly Ile Lys Ala
115 120 125Ile Ile Pro Ser Leu Glu Val Ser Ala Phe Ser Asn Lys Asp Lys Tyr
130 135 140Ile Asp His Ser Ile Ala Pro Lys Val Thr Leu Gln Val Thr Asp Leu145 150 155 160Ser Lys Asn Pro Arg Tyr Ala Asn Val Met Ala Lys Asp Leu Gln Val
165 170 175Leu Gln Tyr Lys Thr Lys Asp Tyr Asp Asp Lys Asn Asn Ile Leu Val
180 185 190Met Glu Ile Ala Phe Lys Glu Ala Thr Trp Glu Asp Phe His Ile Lys
195 200 205Glu Ala Ile Lys Gln Gly Phe Asp Asn Ala Ser Leu Asn Gln Ile Lys
210 215 220Ala Lys Glu Gly Ser Val Phe Tyr Tyr Cys Val Leu Pro Lys Thr Ile225 230 235 240Gln Asn Leu Ser Phe Asp Tyr Phe Ser Leu Ser Asn Lys Gln Phe Lys
245 250 255Thr Leu Ser Phe Ser Thr Ile Pro Thr Gln Asp Thr Thr Gly Ile Gln
260 265 270Ser Asp Leu Ile Pro Lys Asn Asn Phe Leu Val Phe Ser Asn Val Ala
275 280 285Leu Leu Ala Leu Cys Val Phe Phe Leu Val Leu Phe Phe Ile Phe Gly
290 295 300Arg Lys Leu Ile Phe Leu Gly Leu Gly Ile Leu Cys Leu Gly Phe Val305 310 315 320Leu Tyr His Leu Leu Phe Thr Gln Lys SerAla Leu Leu Leu Ala His
325 330 335Lys Lys Ile Arg Ile Leu Pro Thr Gln Asn Ser Thr Ile Leu Gly Leu
340 345 350Ser Lys Asn Glu Met Pro Ile Lys Ile Leu Gly Ser His Asp Asp Tyr
355 360 365Tyr Lys Ile Leu Thr Pro His Glu Gln Ile Gly Trp Val Lys Lys Asp
370375380 Glu Val Lys385 (2) sequence 1059 data: (i) sequence characteristics: length (A): 1455bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1395 (D) other information: (xi) Description of the sequence: sequence 1059: TTCTAATCTC AAAAATGGGT GGTGTTATTA ACA ATG ACA AAA CGA CTT TTT AAA 54
Met Thr Lys Arg Leu Phe Lys
1 5GGG TTG TTA GCG GTT TCT CTT GCT GTG AGT TTG CAT GGT GGT GAA GTT 102Gly Leu Leu Ala Val Ser Leu Ala Val Ser Leu His Gly Gly Glu Val
10 15 20AAG GAA AAA AAG CCG GTT AAG CCG GTT AAA GAA GAT CCG CAA GAA TTA 150Lys Glu Lys Lys Pro Val Lys Pro ValLys Glu Asp Pro Gln Glu Leu
25 30 35GCG GCT AAA AGG GTG GAA GCG TTC AGT CGT TTC TCT AAT GTG GTT TCA 198Ala Ala Lys Arg Val Glu Ala Phe Ser Arg Phe Ser Asn Val Val Ser40 45 50 55GAA ATT GAA AAA AAA TAT GTG GAT AAA ATC AGC ATT TCT GAG ATC ATG 246Glu Ile Glu Lys Lys Tyr Val Asp Lys Ile Ser Ile Ser Glu Ile Met
60 65 70ACT AAA GCG ATT GAA GGC TTG CTC TCT AAT TTG GAC GCG CAT TCA GCG 294Thr Lys Ala Ile Glu Gly Leu Leu Ser Asn Leu Asp Ala His Ser Ala
75 80 85TAT TTG AAT GAA AAG AAG TTT AAG GAA TTT CAA GCC CAA ACC GAG GGC 342Tyr Leu Asn Glu Lys Lys Phe Lys Glu Phe Gln Ala Gln Thr Glu Gly
90 95 100GAA TTT GGG GGG CTT GGG ATC ACG GTG GGC ATG CGC GAT GGC GTT TTA 390Glu Phe Gly Gly Leu Gly Ile Thr Val Gly Met Arg Asp Gly Val Leu
105 110 115ACC GTT ATT GCC CCT TTA GAA GGC ACT CCA GCT TAC AAG GCT GGG GTT 438Thr Val Ile Ala Pro Leu Glu Gly Thr Pro Ala Tyr Lys Ala Gly Val120 125 130 135AAG TCA GGC GAT AAC ATT TTA AAA ATC AAT AAC GAA AGC ACG CTG AGC 486Lys Ser Gly Asp Asn Ile Leu Lys Ile Asn Asn Glu Ser Thr Leu Ser
140 145 150ATG AGC ATT GAT GAT GCG ATC AAC CTC ATG CGC GGC AAG CCA AAA ACC 534Met Ser Ile Asp Asp Ala Ile Asn Leu Met Arg Gly Lys Pro Lys Thr
155 160 165CCT ATT CAG ATC ACC GTT GTA AGA AAA AAC GAG CCA AAA CCT TTA GTG 582Pro Ile Gln Ile Thr Val Val Arg Lys Asn Glu Pro Lys Pro Leu Val
170 175 180TTT AAC ATC ATT AGA GAC ATC ATT AAA GTC CCC TCT GTC TAT GTG AAA 630Phe Asn Ile Ile Arg Asp Ile Ile Lys Leu Pro Ser Val Tyr Val Lys
185 190 195AAG ATT AAA GAA ACC CCT TAT CTG TAT GTG AGA GTG AGT GGT TTT GAC 678Lys Ile Lys Glu Thr Pro Tyr Leu Tyr Val Arg Val Ser Gly Phe Asp200 205 210 215AAG AAT GTT ACC AAA TCG GTT TTA GAA GGC TTA AAA GCT AAC CCT AAG 726Lys Asn Val Thr Lys Ser Val Leu Glu Gly Leu Lys Ala Asn Pro Lys
220 225 230GCT AAG GGG ATC GTG TTG GAT TTA AGG GGC AAT CCT GGA GGG CTA TTA 774Ala Lys Gly Ile Val Leu Asp Leu Arg Gly Asn Pro Gly Gly Leu Leu
235 240 245AAC CAA GCG GTG GGC TTG TCT AAC CTC TTC ATT AAA GAG GGG GTT TTA 822Asn Gln Ala ValGly Leu Ser Asn Leu Phe Ile Lys Glu Gly Val Leu
250 255 260GTC TCT CAA AAA GGC AAA AAT AAA GAA GAA AAT TTA GAA TAC AAG GCT 870Val Ser Gln Lys Gly Lys Asn Lys Glu Glu Asn Leu Glu Tyr Lys Ala
265 270 275AAC GGC AGA GCC CCT TAT ACC AAT TTG CCT ATT GCG GTG TTA GTC AAT 918Asn Gly Arg Ala Pro Tyr Thr Asn Leu Pro Ile Ala Val Leu Val Asn280 285 290 295GGC GGT TCA GCG AGC GCG AGC GAG ATC GTC GCA GGG GCA CTG CAA GAT 966Gly Gly Ser Ala Ser Ala Ser Glu Ile Val Ala Gly Ala Leu Gln Asp
300 305 310CAC AAA CGG GCC GTG ATT ATC GGT GAA AAA ACC TTT GGT AAG GGA AGC 1014His Lys Arg Ala Val Ile Ile Gly Glu Lys Thr Phe Gly Lys Gly Ser
315 320 325GTG CAG ATG CTG CTC CCT GTC AAT AAA GAC GAA GCC ATT AAA ATC ACA 1062Val Gln Met Leu Leu Pro Val Asn Lys Asp Glu Ala Ile Lys Ile Thr
330 335 340ACC GCA CGC TAC TAT TTG CCG AGC GGG CGT ACC ATT CAA GCT AAG GGG 1110Thr Ala Arg Tyr Tyr Leu Pro Ser Gly Arg Thr Ile Gln Ala Lys Gly
345 350 355ATC ACG CCT GAT ATT GTG ATT TAT CCG GGT AAA GTG CCA GAA AAT GAA 1158Ile Thr Pro Asp Ile Val Ile Tyr Pro Gly Lys Val Pro Glu Asn Glu360 365 370 375AAC AAA TTC AGC TTG AAA GAA GCG GAT CTA AAA CAC CAT TTA GAG CAA 1206Asn Lys Phe Ser Leu Lys Glu Ala Asp Leu Lys His His Leu Glu Gln
380 385 390GAG CTT AAA AAG ATT GAT GAT AAA ACC CCC AAT TCC AAA GAG GCG GAT 1254Glu Leu Lys Lys Ile Asp Asp Lys Thr Pro Asn Ser Lys Glu Ala Asp
395 400 405AAA GAC AAG AAA AAC GAA GAG GAA AAA GAG ATT ACT CCT AAA ATG ATC 1302Lys Asp Lys Lys Asn Glu Glu Glu Lys Glu Ile Thr Pro Lys Met Ile
410 415 420AAC GAT GAT ATT CAG CTA AAA ACC GCT ATT GAC AGC TTG AAA ACC TGG 1350Asn Asp Asp Ile Gln Leu Lys Thr Ala Ile Asp Ser Leu Lys Thr Trp
425430435 TCT ATC GTT GAT GAG AAA ATG GAT GAA AAA GCG CCT AAG AAG AAA TAAAA 1400Ser Ile Val Asp Glu Lys Met Asp Glu Lys Ala Pro Lys Lys Lys 440445450 ACTCATGGG TTTTTATTTG AAAAATCGTTA ATGAGTTTT TTCGCTCATC CAATC 1455 (2) sequence 1060 data: (i) sequence characteristics: length (A): 454 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1060: met Thr Lys Arg Leu Phe Lys Gly Leu Leu Ala Val Ser Leu Ala Val 151015 Ser Leu His Gly Gly Glu Val Lys Glu Lys Lys Pro Val Lys Pro Val
20 25 30Lys Glu Asp Pro Gln Glu Leu Ala Ala Lys Arg Val Glu Ala Phe Ser
35 40 45Arg Phe Ser Asn Val Val Ser Glu Ile Glu Lys Lys Tyr Val Asp Lys
50 55 60Ile Ser Ile Ser Glu Ile Met Thr Lys Ala Ile Glu Gly Leu Leu Ser65 70 75 80Asn Leu Asp Ala His Ser Ala Tyr Leu Asn Glu Lys Lys Phe Lys Glu
85 90 95Phe Gln Ala Gln Thr Glu Gly Glu Phe Gly Gly Leu Gly Ile Thr Val
100 105 110Gly Met Arg Asp Gly Val Leu Thr Val Ile Ala Pro Leu Glu Gly Thr
115 120 125Pro Ala Tyr Lys Ala Gly Val Lys Ser Gly Asp Asn Ile Leu Lys Ile
130 135 140Asn Asn Glu Ser Thr Leu Ser Met Ser Ile Asp Asp Ala Ile Asn Leu145 150 155 160Met Arg Gly Lys Pro Lys Thr Pro Ile Gln Ile Thr Val Val Arg Lys
165 170 175Asn Glu Pro Lys Pro Leu Val Phe Asn Ile Ile Arg Asp Ile Ile Lys
180 185 190Leu Pro Ser Val Tyr Val Lys Lys Ile Lys Glu Thr Pro Tyr Leu Tyr
195 200 205Val Arg Val Ser Gly Phe Asp Lys Asn Val Thr Lys Ser Val Leu Glu
210 215 220Gly Leu Lys Ala Asn Pro Lys Ala Lys Gly Ile Val Leu Asp Leu Arg225 230 235 240Gly Asn Pro Gly Gly Leu Leu Asn Gln Ala Val Gly Leu Ser Asn Leu
245 250 255Phe Ile Lys Glu Gly Val Leu Val Ser Gln Lys Gly Lys Asn Lys Glu
260 265 270Glu Asn Leu Glu Tyr Lys Ala Asn Gly Arg Ala Pro Tyr Thr Asn Leu
275 280 285Pro Ile Ala Val Leu Val Asn Gly Gly Ser Ala Ser Ala Ser Glu Ile
290 295 300Val Ala Gly Ala Leu Gln Asp His Lys Arg Ala Val Ile Ile Gly Glu305310 315 320Lys Thr Phe Gly Lys Gly Ser Val Gln Met Leu Leu Pro Val Asn Lys
325 330 335Asp Glu Ala Ile Lys Ile Thr Thr Ala Arg Tyr Tyr Leu Pro Ser Gly
340 345 350Arg Thr Ile Gln Ala Lys Gly Ile Thr Pro Asp Ile Val Ile Tyr Pro
355 360 365Gly Lys Val Pro Glu Asn Glu Asn Lys Phe Ser Leu Lys Glu Ala Asp
370 375 380Leu Lys His His Leu Glu Gln Glu Leu Lys Lys Ile Asp Asp Lys Thr385 390 395 400Pro Asn Ser Lys Glu Ala Asp Lys Asp Lys Lys Asn Glu Glu Glu Lys
405 410 415Glu Ile Thr Pro Lys Met Ile Asn Asp Asp Ile Gln Leu Lys Thr Ala
420 425 430Ile Asp Ser Leu Lys Thr Trp Ser Ile Val Asp Glu Lys Met Asp Glu
435 440 445Lys Ala Pro Lys Lys Lys
450 (2) sequence 1061 data: (i) sequence characteristics: length (A): 1150bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1098 (D) other information: (xi) Description of the sequence: sequence 1061: GATATAAAAG GTTAGTTAAT C ATG GAT TTT TTA AAA GAA AAC TTA AAC ACT 51
Met Asp Phe Leu Lys Glu Asn Leu Asn Thr
1 5 10ATC ATA GAG GGG GAT TGT TTA GAA AAA TTG AAA GAC TTT CCT AAC AGA 99Ile Ile Glu Gly Asp Cys Leu Glu Lys Leu Lys Asp Phe Pro Asn Arg
15 20 25AGC GTT GAT TTT ATC TTT GCT GAC CCC CCA TAT TTT ATG CAA ACA GAG 147Ser Val Asp Phe Ile Phe Ala Asp Pro Pro Tyr Phe Met Gln Thr Glu
30 35 40GGG GAA TTG AAG CGT TTT GAA GGC ACA AAA TTT CAA GGC GTT GAG GAT 195Gly Glu Leu Lys Arg Phe Glu Gly Thr Lys Phe Gln Gly Val Glu Asp
45 50 55TAT TGG GAT AAA TTT GGC TCT TTT AAG GAA TAC GAT GCC TTT TGT TTG 243Tyr Trp Asp Lys Phe Gly Ser Phe Lys Glu Tyr Asp Ala Phe Cys Leu
60 65 70GGT TGG TTG AAA GAA TGC CAA AGG ATT TTA AAA GAT AAT GGC AGT ATT 291Gly Trp Leu Lys Glu Cys Gln Arg Ile Leu Lys Asp Asn Gly Ser Ile75 80 85 90TGT GTG ATA GGG AGT TTT CAA AAT ATT TTT AGA ATT GGT TTT CAT TTG 339Cys Val Ile Gly Ser Phe Gln Asn Ile Phe Arg Ile Gly Phe His Leu
95 100 105CAA AAT TTA GGG TTT TGG ATA CTC AAT GAT ATT ATT TGG CAC AAG AGT 387Gln Asn Leu Gly Phe Trp Ile Leu Asn Asp Ile Ile Trp His Lys Ser
110 115 120AAT CCG GTG CCT AAT TrT GCT GGC AAG AGA TTA TGC AAC GCC CAT GAG 435Asn Pro Val Pro Asn Phe Ala Gly Lys Arg Leu Cys Asn Ala His Glu
125 130 135ACG CTT ATT TGG TGT GCT AAA CAC AAA AAC AGC AAA GTT GCC TTT AAT 483Thr Leu Ile Trp Cys Ala Lys His Lys Asn Ser Lys Val Ala Phe Asn
140 145 150TAT AAA ACA ATG AAG TAC CTC AAT AAC GAC AAA CAA GAA AAA TCG GTT 531Tyr Lys Thr Met Lys Tyr Leu Asn Asn Asp Lys Gln Glu Lys Ser Val155 160 165170TGG CAA ATC CCT ATT TGC ATG GGT AAC GAA AGA CTA AAA GAT GCG CAA 579Trp Gln Ile Pro Ile Cys Met Gly Asn Glu Arg Leu Lys Asp Ala Gln
175 180 185GGT AAA AAA GTG CAT TCC ACG CAA AAA CCA GAA GCG CTT TTA AAA AAA 627Gly Lys Lys Val His Ser Thr Gln Lys Pro Glu Ala Leu Leu Lys Lys
190 195 200ATC ATT TTA AGC GCG ACT AAA CCT AAA GAT ATT ATT TTA GAT CCC TTT 675Ile Ile Leu Ser Ala Thr Lys Pro Lys Asp Ile Ile Leu Asp Pro Phe
205 210 215TTT GGC ACA GGC ACA ACA GGG GCT GTG GCT AAA TCC ATG AAC AGG TAT 723Phe Gly Thr Gly Thr Thr Gly Ala Val Ala Lys Ser Met Asn Arg Tyr
220 225 230TTT ATT GGT ATT GAA AAA GAT TCT TTT TAT ATT AAA GAA GCG GCA AAA 771Phe Ile Gly Ile Glu Lys Asp Ser Phe Tyr Ile Lys Glu Ala Ala Lys235 240 245 250CGC CTG AAT AAC ACT AGG GAT AAA AGC GAT TTT ATC ACT AAT TTA GAT 819Arg Leu Asn Asn Thr Arg Asp Lys Ser Asp Phe Ile Thr Asn Leu Asp
255 260 265TTA GAA ACT AAA CCC CCA AAA ATA CCT ATG AGT CTT TTA ATT TCT AAA 867Leu Glu Thr Lys Pro Pro Lys Ile Pro Met Ser Leu Leu Ile Ser Lys
270 275 280CAA TTA TTA AAA ATC GGG GAT TTT TTA TAC TCA CCT AAC AAA GAA AAA 915Gln Leu Leu Lys Ile Gly Asp Phe Leu Tyr Ser Pro Asn Lys Glu Lys
285 290 295ATT TGT CAA GTT TTA GAA AAC GGA CAA GTG AGG GAT AAT GAA AAC TAT 963Ile Cys Gln Val Leu Glu Asn Gly Gln Val Arg Asp Asn Glu Asn Tyr
300 305 310GAA ACT TCT ATT CAT AAG ATG AGC GCT AAA TAT TTG AAT AAA ACC AAC 1011Glu Thr Ser Ile His Lys Met Ser Ala Lys Tyr Leu Asn Lys Thr Asn315 320 325 330CAT AAT GGC TGG AAA TTT TTT TAT GCG TAT TAC CAA AAT CAA TTT TTA 1059His Asn Gly Trp Lys Phe Phe Tyr Ala Tyr Tyr Gln Asn Gln Phe Leu
335 340 345TTG CTA GAT GAA TTG CGT TAT ATC TGC CAA AAG GAC TCT TAATGGACTA TC 1110Leu Leu Asp Glu Leu Arg Tyr Ile Cys Gln Lys Asp Ser
350355 AAACCTTTAA CGAGATTTTT AATCGTTTTG TCTTTGGAAC 1150 (2) sequence 1062 data: (i) sequence characteristics: length (A): 359 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1062: met Asp Phe Leu Lys Glu Asn Leu Asn Thr Ile Ile Glu Gly Asp Cys 151015 Leu Glu Lys Leu Lys Asp Phe Pro Asn Arg Ser Val Asp Phe Ile Phe
20 25 30Ala Asp Pro Pro Tyr Phe Met Gln Thr Glu Gly Glu Leu Lys Arg Phe
35 40 45Glu Gly Thr Lys Phe Gln Gly Val Glu Asp Tyr Trp Asp Lys Phe Gly
50 55 60Ser Phe Lys Glu Tyr Asp Ala Phe Cys Leu Gly Trp Leu Lys Glu Cys65 70 75 80Gln Arg Ile Leu Lys Asp Asn Gly Ser Ile Cys Val Ile Gly Ser Phe
85 90 95Gln Asn Ile Phe Arg Ile Gly Phe His Leu Gln Asn Leu Gly Phe Trp
100 105 110Ile Leu Asn Asp Ile Ile Trp His Lys Ser Asn Pro Val Pro Asn Phe
115 120 125Ala Gly Lys Arg Leu Cys Asn Ala His Glu Thr Leu Ile Trp Cys Ala
130135 140Lys His Lys Asn Ser Lys Val Ala Phe Asn Tyr Lys Thr Met Lys Tyr145 150 155 160Leu Asn Asn Asp Lys Gln Glu Lys Ser Val Trp Gln Ile Pro Ile Cys
165 170 175Met Gly Asn Glu Arg Leu Lys Asp Ala Gln Gly Lys Lys Val His Ser
180 185 190Thr Gln Lys Pro Glu Ala Leu Leu Lys Lys Ile Ile Leu Ser Ala Thr
195 200 205Lys Pro Lys Asp Ile Ile Leu Asp Pro Phe Phe Gly Thr Gly Thr Thr
210 215 220Gly Ala Val Ala Lys Ser Met Asn Arg Tyr Phe Ile Gly Ile Glu Lys225 230 235 240Asp Ser Phe Tyr Ile Lys Glu Ala Ala Lys Arg Leu Asn Asn Thr Arg
245 250 255Asp Lys Ser Asp Phe Ile Thr Asn Leu Asp Leu Glu Thr Lys Pro Pro
260 265 270Lys Ile Pro Met Ser Leu Leu Ile Ser Lys Gln Leu Leu Lys Ile Gly
275 280 285Asp Phe Leu Tyr Ser Pro Asn Lys Glu Lys Ile Cys Gln Val Leu Glu
290 295 300Asn Gly Gln Val Arg Asp Asn Glu Asn Tyr Glu Thr Ser Ile His Lys305 310 315 320Met Ser Ala Lys Tyr Leu Asn Lys Thr Asn His Asn Gly Trp Lys Phe
325 330 335Phe Tyr Ala Tyr Tyr Gln Asn Gln Phe Leu Leu Leu Asp Glu Leu Arg
340 345 350Tyr Ile Cys Gln Lys Asp Ser
355 (2) sequence 1063 data: (i) sequence characteristics: (A) length: 1536bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1497 (D) other information: (xi) Description of the sequence: sequence 1063: TAGAAAAGAT CAAACAATTA TAAAAGGATA AAA ATG GAT CAT TTA AAG CAT TTG 54
Met Asp His Leu Lys His Leu
1 5CAG CAA TTG CAA AAC ATT GAA AGG ATC GTG CTT TCA GGC ATT GTG TTG 102Gln Gln Leu Gln Asn Ile Glu Arg Ile Val Leu Ser Gly Ile Val Leu
10 15 20GCC AAT CAT AAG ATT GAA GAG GTC CAT AGC GTT TTA GAG CCT AGC GAT 150Ala Asn His Lys Ile Glu Glu Val His Ser Val Leu Glu Pro Ser Asp
25 30 35TTT TAC TAC CCG CCT AAC GGC TTA TTT TTT GAA ATC GCT TTA AAA CTG 198Phe Tyr Tyr Pro Pro Asn Gly Leu Phe Phe Glu Ile Ala Leu Lys Leu40 45 50 55CAT GAA GAA GAT TGC CCC ATT GAT GAG AAT TTT ATC CGC CAA AAA ATG 246His Glu Glu Asp Cys Pro Ile Asp Glu Asn Phe Ile Arg Gln Lys Met
60 65 70CCT AAA GAC AAG CAG ATC AAA GAA GAA GAT CTA GTC GCT ATT TTT GCG 294Pro Lys Asp Lys Gln Ile Lys Glu Glu Asp Leu Val Ala Ile Phe Ala
75 80 85GCA AGC CCC ATA GAT AAT ATT GAA GCC TAT GTG GAA GAG ATT AAA AAC 342Ala Ser Pro Ile Asp Asn Ile Glu Ala Tyr Val Glu Glu Ile Lys Asn
90 95 100GCT TCC ATT AAA CGA AAA CTT TTT GGC TTG GCT AAC ACC ATT AGA GAG 390Ala Ser Ile Lys Arg Lys Leu Phe Gly Leu Ala Asn Thr Ile Arg Glu
105 110 115CAA GCC CTA GAA AGC GCG CAA AAA TCC AGC GAT ATT TTA GGC GCT GTG 438Gln Ala Leu Glu Ser Ala Gln Lys Ser Ser Asp Ile Leu Gly Ala Val120 125 130 135GAG CGA GAA GTC TAT GCG TTA TTG AAT GGC AGC ACC ATA GAA GGC TTT 486Glu Arg Glu Val Tyr Ala Leu Leu Asn Gly Ser Thr Ile Glu Gly Phe
140 145 150AGG AAT ATT AAA GAA GTG CTT GAA AGC GCA ATG GAT CTC ATT ACA GAA 534Arg Asn Ile Lys Glu Val Leu Glu Ser Ala Met Asp Leu Ile Thr Glu
155 160 165AAC CAA AGA AAG GGG AGT TTG GAA GTT ACT GGC ATA CCG ACT GGC TTT 582Asn Gln Arg Lys Gly Ser Leu Glu Val Thr Gly Ile Pro Thr Gly Phe
170 175 180GTC CAA TTG GAT AAC TAT ACG AGC GGT TTC AAT AAG GGG AGT TTA GTC 630Val Gln Leu Asp Asn Tyr Thr Ser Gly Phe Asn Lys Gly Ser Leu Val
185 190 195ATT ATA GGG GCA AGG CCG TCT ATG GGT AAA ACT AGT TTG ATG ATG AAC 678Ile Ile Gly Ala Arg Pro Ser Met Gly Lys Thr Ser Leu Met Met Asn200 205 210 215ATG GTC TTA AGC GCG CTC AAT GAC GAT AGG GGG GTA GCG GTT TTT AGT 726Met Val Leu Ser Ala Leu Asn Asp Asp Arg Gly Val Ala Val Phe Ser
220 225 230TTA GAA ATG TCC GCA GAG CAA CTC GCT TTA AGG GCG TTA TCG GAT CTC 774Leu Glu Met Ser Ala Glu Gln Leu Ala Leu Arg Ala Leu Ser Asp Leu
235 240 245ACC TCT ATT AAC ATG CAT GAT TTA GAA AGC GGG AGG CTT GAT GAT GAT 822Thr Ser Ile Asn Met His Asp Leu Glu Ser Gly Arg Leu Asp Asp Asp
250 255 260CAA TGG GAA AAT TTA GCC AAA TGC TTT GAT CAC CTT TCG CAA AAA AAA 870GlnTrp Glu Asn Leu Ala Lys Cys Phe Asp His Leu Ser Gln Lys Lys
265 270 275CTC TTT TTC TAC GAT AAA AGT TAT GTG AGG ATA GAG CAA ATC CGC TTG 918Leu Phe Phe Tyr Asp Lys Ser Tyr Val Arg Ile Glu Gln Ile Arg Leu280 285 290 295CAA CTA CGA AAG CTT AAA TCC CAA CAC AAG GAA TTG GGT ATC GCT TTT 966Gln Leu Arg Lys Leu Lys Ser Gln His Lys Glu Leu Gly Ile Ala Phe
300 305 310ATT GAC TAT TTG CAG CTC ATG TCA GGG AGT AAA GCC ACT AAA GAG CGC 1014Ile Asp Tyr Leu Gln Leu Met Ser Gly Ser Lys Ala Thr Lys Glu Arg
315 320 325CAT GAG CAA ATC GCT GAA ATT TCA AGG GAG CTT AAA ACT TTA GCC AGA 1062His Glu Gln Ile Ala Glu Ile Ser Arg Glu Leu Lys Thr Leu Ala Arg
330 335 340GAA TTA GAA ATC CCT ATC ATA GCG TTA GTG CAA CTC AAC CGC AGC CTA 1110Glu Leu Glu Ile Pro Ile Ile Ala Leu Val Gln Leu Asn Arg Ser Leu
345 350 355GAA AAC CGA GAC GAT AAA CGG CCC ATT CTT TCG GAT ATC AAA GAC AGC 1158Glu Asn Arg Asp Asp Lys Arg Pro Ile Leu Ser Asp Ile Lys Asp Ser360 365 370 375GGG GGG ATT GAA CAA GAC GCT GAT ATT GTT TTA TTT TTA TAT AGA GGC 1206Gly Gly Ile Glu Gln Asp Ala Asp Ile Val Leu Phe Leu Tyr Arg Gly
380 385 390TAT ATC TAT CAA ATG AGG GCT GAA GAC AAC AAA ATA GAC AAA CTC AAA 1254Tyr Ile Tyr Gln Met Arg Ala Glu Asp Asn Lys Ile Asp Lys Leu Lys
395 400 405AAA GAA GGT AAA ATT GAA GAG GCG CAA GAG TTG TAC TTA AAA GTT AAT 1302Lys Glu Gly Lys Ile Glu Glu Ala Gln Glu Leu Tyr Leu Lys Val Asn
410 415 420GAA GAA AGG CGT ATC CAC AAG CAA AAT GGC AGC ATT GAA GAG GCT GAA 1350Glu Glu Arg Arg Ile His Lys Gln Asn Gly Ser Ile Glu Glu Ala Glu
425 430 435ATC ATT GTG GCT AAA AAC AGG AAT GGG GCT ACA GGA ACG GTT TAT ACG 1398Ile Ile Val Ala Lys Asn Arg Asn Gly Ala Thr Gly Thr Val Tyr Thr440 445 450 455CGC TTT AAC GCT CCT TTC ACG CGC TAT GAA GAC ATG CCC ATA GAT TCC 1446Arg Phe Asn Ala Pro Phe Thr Arg Tyr Glu Asp Met Pro Ile Asp Ser
460 465 470CAT TTA GAA GAA GGG CAA GAA ACT AAA GTG GAT TAT GAT ATA GTT ACA 1494His Leu Glu Glu Gly Gln Glu Thr Lys Val Asp Tyr Asp Ile Val Thr
475480485 ACT TGAAAGACAA AACTTTTCAG GGGGCGTTTG AACTTCTTA 1536Thr (2) sequence 1064 data: (i) sequence characteristics: length (A): 488 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1064: met Asp His Leu Lys His Leu Gln Gln Leu Gln Asn Ile Glu Arg Ile 151015 Val Leu Ser Gly Ile Val Leu Ala Asn His Lys Ile Glu Glu Val His
20 25 30Ser Val Leu Glu Pro Ser Asp Phe Tyr Tyr Pro Pro Asn Gly Leu Phe
35 40 45Phe Glu Ile Ala Leu Lys Leu His Glu Glu Asp Cys Pro Ile Asp Glu
50 55 60Asn Phe Ile Arg Gln Lys Met Pro Lys Asp Lys Gln Ile Lys Glu Glu65 70 75 80Asp Leu Val Ala Ile Phe Ala Ala Ser Pro Ile Asp Asn Ile Glu Ala
85 90 95Tyr Val Glu Glu Ile Lys Asn Ala Ser Ile Lys Arg Lys Leu Phe Gly
100 105 110Leu Ala Asn Thr Ile Arg Glu Gln Ala Leu Glu Ser Ala Gln Lys Ser
115 120 125Ser Asp Ile Leu Gly Ala Val Glu Arg Glu Val Tyr Ala Leu Leu Asn
130 135 140Gly Ser Thr Ile Glu Gly Phe Arg Asn Ile Lys Glu Val Leu Glu Ser145 150 155 160Ala Met Asp Leu Ile Thr Glu Asn Gln Arg Lys Gly Ser Leu Glu Val
165 170 175Thr Gly Ile Pro Thr Gly Phe Val Gln Leu Asp Asn Tyr Thr Ser Gly
180 185 190Phe Asn Lys Gly Ser Leu Val Ile Ile Gly Ala Arg Pro Ser Met Gly
195 200 205Lys Thr Ser Leu Met Met Asn Met Val Leu Ser Ala Leu Asn Asp Asp
210 215 220Arg Gly Val Ala Val Phe Ser Leu Glu Met Ser Ala Glu Gln Leu Ala225 230 235 240Leu Arg Ala Leu Ser Asp Leu Thr Ser Ile Asn Met His Asp Leu Glu
245 250 255Ser Gly Arg Leu Asp Asp Asp Gln Trp Glu Asn Leu Ala Lys Cys Phe
260 265 270Asp His Leu Ser Gln Lys Lys Leu Phe Phe Tyr Asp Lys Ser Tyr Val
275 280 285Arg Ile Glu Gln Ile Arg Leu Gln Leu Arg Lys Leu Lys Ser Gln His
290 295 300Lys Glu Leu Gly Ile Ala Phe Ile Asp Tyr Leu Gln Leu Met Ser Gly305 310 315 320Ser Lys Ala Thr Lys Glu Arg His Glu Gln Ile Ala Glu Ile Ser Arg
325 330 335Glu Leu Lys Thr Leu Ala Arg Glu Leu Glu Ile Pro Ile Ile Ala Leu
340 345 350Val Gln Leu Asn Arg Ser Leu Glu Asn Arg Asp Asp Lys Arg Pro Ile
355 360 365Leu Ser Asp Ile Lys Asp Ser Gly Gly Ile Glu Gln Asp Ala Asp Ile
370 375 380Val Leu Phe Leu Tyr Arg Gly Tyr Ile Tyr Gln Met Arg Ala Glu Asp385 390 395 400Asn Lys Ile Asp Lys Leu Lys Lys Glu Gly Lys Ile Glu Glu Ala Gln
405 410 415Glu Leu Tyr Leu Lys Val Asn Glu Glu Arg Arg Ile His Lys Gln Asn
420 425 430Gly Ser Ile Glu Glu Ala Glu Ile Ile Val Ala Lys Asn Arg Asn Gly
435 440 445Ala Thr Gly Thr Val Tyr Thr Arg Phe Asn Ala Pro Phe Thr Arg Tyr
450 455 460Glu Asp Met Pro Ile Asp Ser His Leu Glu Glu Gly Gln Glu Thr Lys465 470 475 480Val Asp Tyr Asp Ile Val Thr Thr
485 (2) sequence 1065 data: (i) sequence characteristics: length (A): 1246bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 98...1207 (D) other information: (xi) Description of the sequence: sequence 1065: GAAACGCATA AGGGGGTTGG CTATCGCTTT AACCCACTAT GAAAAAAAAT CCCTTAAACT 60CTTTTTAGGG ATTTATTTAG GCTCTTCGTT TGTGTTG ATG CTA GTG ATT AGC GTT 115
Met Leu Val Ile Ser Val
1 5TTA GCG TTT AAC TAT GAA AAA AAC GAA AAA ATC AAA ATG ATA CGC ATG 163Leu Ala Phe Asn Tyr Glu Lys Asn Glu Lys Ile Lys Met Ile Arg Met
10 15 20GAC ATG GAC AAA ATG GCT TCT AAG ATC GCT AGC GAA GTG ATT GCC TTG 211Asp Met Asp Lys Met Ala Ser Lys Ile Ala Ser Glu Val Ile Ala Leu
25 30 35CAC ATG CAA ACG CAT GGG GAT TAT CAA AAC GCT TTA AAC GCT CTC ATT 259His Met Gln Thr His Gly Asp Tyr Gln Asn Ala Leu Asn Ala Leu Ile
40 45 50TCA CGC TAT AAA GAC GCT TCC ATA GCC CTT TTT GAT AGT AAA AAG CGT 307Ser Arg Tyr Lys Asp Ala Ser Ile Ala Leu Phe Asp Ser Lys Lys Arg55 60 65 70GTT TTG TAT TCT AAT ATC CCT GAA AGC GCC AAT TTG ATT AAA AAC CAT 355Val Leu Tyr Ser Asn Ile Pro Glu Ser Ala Asn Leu Ile Lys Asn His
75 80 85AAA GAA GCG GGC TTT TTT AGT TTT AGG GGA GAG TAT TAC CTA TTG AGC 403Lys Glu Ala Gly Phe Phe Ser Phe Arg Gly Glu Tyr Tyr Leu Leu Ser
90 95 100GAT GAA ACT TTC GCT CAC TTA GGC GTG GCT AAA ATG CTT TTT AAA AAT 451Asp Glu Thr Phe Ala His Leu Gly Val Ala Lys Met Leu Phe Lys Asn
105 110 115TCT AAA CCC CTT CAT TTT TCT TCT TTG TAT CGT AAC ATT GTT TTA GTG 499Ser Lys Pro Leu His Phe Ser Ser Leu Tyr Arg Asn Ile Val Leu Val
120 125 130TTT GTT GTA GCG TTT TTA TGC GTG ATA GGG GTT TCT GTG TTT TTG GGG 547Phe Val Val Ala Phe Leu Cys Val Ile Gly Val Ser Val Phe Leu Gly135 140 145 150CGT TTG TTT TTA AAG CCC ATT AGG AAT GAA ATC ACC CGC ATT CAT CAT 595Arg Leu Phe Leu Lys Pro Ile Arg Asn Glu Ile Thr Arg Ile Asp His
155 160 165TTT TTA AAA AAC ACC ACG CAT GAA TTA AAC ACC CCC ATG AGC GCT TTA 643Phe Leu Lys Asn Thr Thr His Glu Leu Asn Thr Pro Met Ser Ala Leu
170 175 180GTC TTG TCT TTA AAA ACC TTA GAA GAC AAC CAA CAA CAC CGC CGC ATT 691Val Leu Ser Leu Lys Thr Leu Glu Asp Asn Gln Gln His Arg Arg Ile
185 190 195AAA ATC GCT ATC CAG CGC ATG AGT TTT TTA TAC CGC TCG CTC TCG TAT 739Lys Ile Ala Ile Gln Arg Met Ser Phe Leu Tyr Arg Ser Leu Ser Tyr
200 205 210TTA GTG ATG CAA GAT ATT GAG CGC GAA TCT TTT GTG CTT TTA GAT TTA 787Leu Val Met Gln Asp Ile Glu Arg Glu Ser Phe Val Leu Leu Asp Leu215 220 225 230AAA GCC CTG ATT ATT AAA GAA AAC ACG CTT TTT AGC GAG ATG ATA GAC 835Lys Ala Leu Ile Ile Lys Glu Asn Thr Leu Phe Ser Glu Met Ile Asp
235 240 245TAC CAC AAG CTG GAA TTT AAA AGC GAT TTA GTG GAA GTG GAA CTT AAA 883Tyr His Lys Leu Glu Phe Lys Ser Asp Leu Val Glu Val Glu Leu Lys
250 255 260GCT AAA GAG CAG GAT TTC ATT TCG CTT TAT AGC AAT TTG CTC ATG AAC 931Ala Lys Glu Gln Asp Phe Ile Ser Leu Tyr Ser Asn Leu Leu Met Asn
265 270 275GCG ATC AAA TAC AGC GTC ATG AAT GGG TAT ATC CAC ATA GAG CTA ACG 979Ala Ile Lys Tyr Ser Val Met Asn Gly Tyr Ile His Ile Glu Leu Thr
280 285 290CAT GCG TTT TTG AAA GTG AAA AAT TTA GGG TAT GAA ATC CCT AAA GAC 1027His Ala Phe Leu Lys Val Lys Asn Leu Gly Tyr Glu Ile Pro Lys Asp295 300 305 310AAG ATC ACA GAA TTA AGC GTT CGT TAT GTG CGT TTC AAT TCT GGC GTG 1075Lys Ile Thr Glu Leu Ser Val Arg Tyr Val Arg Phe Asn Ser Gly Val
315 320 325TTG GGT TAT GGT ATA GGG TTA GGT TTG GTG AAA AAA GTG TGC GAA AAG 1123Leu Gly Tyr Gly Ile Gly Leu Gly Leu Val Lys Lys Val Cys Glu Lys
330 335 340TAT AAA ATG CGT TTA GAA ATT CAT AGC GAA CCC TCT TTA AAG GGA TCG 1171Tyr Lys Met Arg Leu Glu Ile His Ser Glu Pro Ser Leu Lys Gly Ser
345 350 355TTT TAT GAA AAT TCG TTT TGC GTT CAA TTT CAA GGA TAAAGATGCT TTCAGT 1223Phe Tyr Glu Asn Ser Phe Cys Val Gln Phe Gln Gly
360365370 GTATGAAAAA GTGAATGCTC TAG 1246 (2) sequence 1066 data: (i) sequence characteristics: length (A): 370 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1066: met Leu Val Ile Ser Val Leu Ala Phe Asn Tyr Glu Lys Asn Glu Lys 151015 Ile Lys Met Ile Arg Met Asp Met Asp Lys Met Ala Ser Lys Ile Ala
20 25 30Ser Glu Val Ile Ala Leu His Met Gln Thr His Gly Asp Tyr Gln Asn
35 40 45Ala Leu Asn Ala Leu Ile Ser Arg Tyr Lys Asp Ala Ser Ile Ala Leu
50 55 60Phe Asp Ser Lys Lys Arg Val Leu Tyr Ser Asn Ile Pro Glu Ser Ala65 70 75 80Asn Leu Ile Lys Asn His Lys Glu Ala Gly Phe Phe Ser Phe Arg Gly
85 90 95Glu Tyr Tyr Leu Leu Ser Asp Glu Thr Phe Ala His Leu Gly Val Ala
100 105 110Lys Met Leu Phe Lys Asn Ser Lys Pro Leu His Phe Ser Ser Leu Tyr
115 120 125Arg Asn Ile Val Leu Val Phe Val Val Ala Phe Leu Cys Val Ile Gly
130 135 140Val Ser Val Phe Leu Gly Arg Leu Phe Leu Lys Pro Ile Arg Asn Glu145 150 155 160Ile Thr Arg Ile Asp His Phe Leu Lys Asn Thr Thr His Glu Leu Asn
165 170 175Thr Pro Met Ser Ala Leu Val Leu Ser Leu Lys Thr Leu Glu Asp Asn
180 185 190Gln Gln His Arg Arg Ile Lys Ile Ala Ile Gln Arg Met Ser Phe Leu
195 200 205Tyr Arg Ser Leu Ser Tyr Leu Val Met Gln Asp Ile Glu Arg Glu Ser
210 215 220Phe Val Leu Leu Asp Leu Lys Ala Leu Ile Ile Lys Glu Asn Thr Leu225 230 235 240Phe Ser Glu Met Ile Asp Tyr His Lys Leu Glu Phe Lys Ser Asp Leu
245 250 255Val Glu Val Glu Leu Lys Ala Lys Glu Gln Asp Phe Ile Ser Leu Tyr
260 265 270Ser Asn Leu Leu Met Asn Ala Ile Lys Tyr Ser Val Met Asn Gly Tyr
275 280 285Ile His Ile Glu Leu Thr His Ala Phe Leu Lys Val Lys Asn Leu Gly
290 295 300Tyr Glu Ile Pro Lys Asp Lys Ile Thr Glu Leu Ser Val Arg Tyr Val305 310 315 320Arg Phe Asn Ser Gly Val Leu Gly Tyr Gly Ile Gly Leu Gly Leu Val
325 330 335Lys Lys Val Cys Glu Lys Tyr Lys Met Arg Leu Glu Ile His Ser Glu
340 345 350Pro Ser Leu Lys Gly Ser Phe Tyr Glu Asn Ser Phe Cys Val Gln Phe
355 360 365Gln Gly
370 (2) sequence 1067 data: (i) sequence characteristics: length (A): 703bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 665 (D) other information: (xi) Description of the sequence: sequence 1067: GGGATAGTTT TAAAAATGAT GAAGAGTTTT TAACATTTTC TTACGCTTGG ATTGATAAA 59ATG CTG CCC AAA CTT AAA GAC ACA GGG AGT TTT TAT ATC TTT AAT ACC 107Met Leu Pro Lys Leu Lys Asp Thr Gly Ser Phe Tyr Ile Phe Asn Thr 151015 CCT TTT AAT TGC GCT TTA TTT TTA GCG TAT TTG CAC CAT AAA AAA GTG 155Pro Phe Asn Cys Ala Leu Phe Leu Ala Tyr Leu His His Lys Lys Val
20 25 30CAT TTT TTA AAT TTT ATC ACT TGG GTT AAA AAA GAT GGG TTT GCC AAC 203His Phe Leu Asn Phe Ile Thr Trp Val Lys Lys Asp Gly Phe Ala Asn
35 40 45GCC AAA AAG CGT TAT AAC CAC GCG CAA GAA AGC ATT TTA TTT TAT AGC 251Ala Lys Lys Arg Tyr Asn His Ala Gln Glu Ser Ile Leu Phe Tyr Ser
50 55 60ATG CAC AAG AAA AAC TAC ACC TTT AAT GCC GAT GAG ATT CGC ATC GCT 299Met His Lys Lys Asn Tyr Thr Phe Asn Ala Asp Glu Ile Arg Ile Ala 65 70 75 80TAT GAA TCC GCT GAA CGC ATC AAA CAT GCT CAA AGT AAG GGG ATT TTA 347Tyr Glu Ser Ala Glu Arg Ile Lys His Ala Gln Ser Lys Gly Ile Leu
85 90 95AAA AAT AAC AAA CGC TGG TTC CCT AAC CCT AAG GGC AAA TTA TGC CTT 395Lys Asn Asn Lys Arg Trp Phe Pro Asn Pro Lys Gly Lys Leu Cys Leu
100 105 110GAT GTG TGG GAA ATC ACT TCA CAA AGG CAT GTT GAA AAA GAG AAG GGT 443Asp Val Trp Glu Ile Thr Ser Gln Arg His Val Glu Lys Glu Lys Gly
115 120 125AAA ATC CTT AAG CCC AAA CAC CCC AGC ATC AAA CCT AAA GCG CTC ATT 491Lys Ile Leu Lys Pro Lys His Pro Ser Ile Lys Pro Lys Ala Leu Ile
130 135 140GAA CGC ATG ATA AAA GCT AGC TCT CAC AAA AAC GAT TTG ATT TTA GAT 539Glu Arg Met Ile Lys Ala Ser Ser His Lys Asn Asp Leu Ile Leu Asp145 150 155 160TTG TTT AGC GGC AGT GGC ATG ACT AGC TTA GTG GCT AAA AGT TTG GAG 587Leu Phe Ser Gly Ser Gly Met Thr Ser Leu Val Ala Lys Ser Leu Glu
165 170 175CGT AAT TTT ATA GGG TGT GAG AGC CAT GCT GAA TAG GTG CAT GGG AGT 635Arg Asn Phe Ile Gly Cys Glu Ser His Ala Glu Tyr Val His Gly Ser
180 185 190TTG GAA ATG TTT AGG TAT AAT GAA TGC GAA TAAAAAAGGA TATTTGACAT GCCA 689Leu Glu Met Phe Arg Tyr Asn Glu Cys Glu
195200 AAATTAGAAA AAAT 703 (2) sequence 1068 data: (i) sequence characteristics: length (A): 202 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1068: met Leu Pro Lys Leu Lys Asp Thr Gly Ser Phe Tyr Ile Phe Asn Thr 151015 Pro Phe Asn Cys Ala Leu Phe Leu Ala Tyr Leu His His Lys Lys Val
20 25 30His Phe Leu Asn Phe Ile Thr Trp Val Lys Lys Asp Gly Phe Ala Asn
35 40 45Ala Lys Lys Arg Tyr Asn His Ala Gln Glu Ser Ile Leu Phe Tyr Ser
50 55 60Met His Lys Lys Asn Tyr Thr Phe Asn Ala Asp Glu Ile Arg Ile Ala65 70 75 80Tyr Glu Ser Ala Glu Arg Ile Lys His Ala Gln Ser Lys Gly Ile Leu
85 90 95Lys Asn Asn Lys Arg Trp Phe Pro Asn Pro Lys Gly Lys Leu Cys Leu
100 105 110Asp Val Trp Glu Ile Thr Ser Gln Arg His Val Glu Lys Glu Lys Gly
115 120 125Lys Ile Leu Lys Pro Lys His Pro Ser Ile Lys Pro Lys Ala Leu Ile
130 135 140Glu Arg Met Ile Lys Ala Ser Ser His Lys Asn Asp Leu Ile Leu Asp145 150 155 160Leu Phe Ser Gly Ser Gly Met Thr Ser Leu Val Ala Lys Ser Leu Glu
165 170 175Arg Asn Phe Ile Gly Cys Glu Ser His Ala Glu Tyr Val His Gly Ser
180 185 190Leu Glu Met Phe Arg Tyr Asn Glu Cys Glu
195200 (2) sequence 1069 data: (i) sequence characteristics: length (A): 1448bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1404 (D) other information: (xi) Description of the sequence: sequence 1069: AGAGTTCTAG GGGCGTGGCG TATAAGTCAA GCGAATATTC TAGCGAAGAA AAACAAGAGG 60AATAAC ATG AAC GAA ACG CTT TAT TGC AGT TTT TGC AAA AAA CCA GAA 108
Met Asn Glu Thr Leu Tyr Cys Ser Phe Cys Lys LysPro Glu
1 5 10TCA AGA GAT CCC AAA AAA CGC CGC ATT ATT TTT GCG AGC AAT CTC AAT 156Ser Arg Asp Pro Lys Lys Arg Arg Ile Ile Phe Ala Ser Asn Leu Asn15 20 25 30AAA GAT GTG TGC GTG TGC GAA TAT TGT ATA GAT GTG ATG CAT GGG GAA 204Lys Asp Val Cys Val Cys Glu Tyr Cys Ile Asp Val Met His Gly Glu
35 40 45TTG CAC AAA TAC GAC AAT TCT TTA TTG GCG CTC AAA AGA GAC CGA TTG 252Leu His Lys Tyr Asp Asn Ser Leu Leu Ala Leu Lys Arg Asp Arg Leu
50 55 60AGA AGA ATG GAA TCT AGC GCT TAT GAA GAA GAG TTT TTA CTC TCT TAC 300Arg Arg Met Glu Ser Ser Ala Tyr Glu Glu Glu Phe Leu Leu Ser Tyr
65 70 75ATT CCA GCC CCT AAA GAG CTT AAG GCG GTT TTA GAC AAT TAT GTG ATA 348Ile Pro Ala Pro Lys Glu Leu Lys Ala Val Leu Asp Asn Tyr Val Ile
80 85 90GGG CAA GAG CAG GCT AAA AAG GTT TTT TCC GTA GCC GTG TAT AAC CAT 396Gly Gln Glu Gln Ala Lys Lys Val Phe Ser Val Ala Val Tyr Asn His95 100 105 110TAC AAA CGC TTA TCT TTT AAA GAA AAA CTC AAA AAA CAA GAC AAC CAA 444Tyr Lys Arg Leu Ser Phe Lys Glu Lys Leu Lys Lys Gln Asp Asn Gln
115 120 125GAC AGC AAT GTG GAG TTA GAG CAT TTA GAA GAA GTG GAG TTG AGC AAG 492Asp Ser Asn Val Glu Leu Glu His Leu Glu Glu Val Glu Leu Ser Lys
130 135 140TCT AAT ATT TTA CTA ATC GGC CCT ACA GGA TCA GGC AAA ACT TTA ATG 540Ser Asn Ile Leu Leu Ile Gly Pro Thr Gly Ser Gly Lys Thr Leu Met
145 150155GCG CAA ACT CTG GCC AAG CAT TTG GAT ATT CCT ATC GCC ATT AGC GAT 588Ala Gln Thr Leu Ala Lys His Leu Asp Ile Pro Ile Ala Ile Ser Asp
160 165 170GCG ACT AGC TTG ACT GAA GCG GGC TAT GTG GGC GAA GAC GTG GAA AAT 636Ala Thr Ser Leu Thr Glu Ala Gly Tyr Val Gly Glu Asp Val Glu Asn175 180 185 190ATT CTC ACA AGA TTG TTG CAA GCG AGC GAC TGG AAT GTC CAA AAA GCC 684Ile Leu Thr Arg Leu Leu Gln Ala Ser Asp Trp Asn Val Gln Lys Ala
195 200 205CAA AAA GGC ATT GTG TTT ATT GAT GAG ATT GAT AAA ATC AGC CGT TTG 732Gln Lys Gly Ile Val Phe Ile Asp Glu Ile Asp Lys Ile Ser Arg Leu
210 215 220TCA GAA AAC CGC TCT ATC ACT AGA GAT GTT TCT GGC GAG GGC GTT CAG 780Ser Glu Asn Arg Ser Ile Thr Arg Asp Val Ser Gly Glu Gly Val Gln
225 230 235CAA GCG TTG TTG AAA ATC GTT GAA GGT TCT TTA GTG AAT ATC CCC CCC 828Gln Ala Leu Leu Lys Ile Val Glu Gly Ser Leu Val Asn Ile Pro Pro
240 245 250AAA GGC GGC AGA AAG CAC CCT GAG GGC AAT TTC ATT CAA ATT GAC ACG 876Lys Gly Gly Arg Lys His Pro Glu Gly Asn Phe Ile Gln Ile Asp Thr255 260 265 270AGC GAT ATT TTA TTC ATT TGT GCT GGA GCG TTT GAT GGG TTA GCT GAA 924Ser Asp Ile Leu Phe Ile Cys Ala Gly Ala Phe Asp Gly Leu Ala Glu
275 280 285ATC ATT AAA AAA CGC ACC ACG CAG AAT GTG TTG GGT TTC ACT CAA GAA 972Ile Ile Lys Lys Arg Thr Thr Gln Asn Val Leu Gly Phe Thr Gln Glu
290 295 300AAG ATG AGC AAA AAA GAG CAA GAA GCG ATC TTG CAT TTA GTC CAA ACC 1020Lys Met Ser Lys Lys Glu Gln Glu Ala Ile Leu His Leu Val Gln Thr
305 310 315CAT GAC CTG GTT ACT TAT GGG CTT ATC CCT GAG CTT ATT GGC CGT TTG 1068His Asp Leu Val Thr Tyr Gly Leu Ile Pro Glu Leu Ile Gly Arg Leu
320 325 330CCG GTT TTA AGC ACG CTA GAT AGC ATC AGT TTA GAA GCG ATG GTG GAT 1116Pro Val Leu Ser Thr Leu Asp Ser Ile Ser Leu Glu Ala Met Val Asp335 340 345 350ATT TTA CAA AAA CCT AAA AAC GCT CTT ATC AAG CAA TAC CAG CAG CTT 1164Ile Leu Gln Lys Pro Lys Asn Ala Leu Ile Lys Gln Tyr Gln Gln Leu
355 360 365TTC AAA ATG GAT GAG GTG GAT TTG ATC TTT GAA GAA GAA GCC ATT AAA 1212Phe Lys Met Asp Glu Val Asp Leu Ile Phe Glu Glu Glu Ala Ile Lys
370 375 380GAA ATC GCT CAA CTC GCA TTA GAA AGA AAA ACC GGG GCT AGG GGC TTA 1260Glu Ile Ala Gln Leu Ala Leu Glu Arg Lys Thr Gly Ala Arg Gly Leu
385 390 395AGG GCG ATC ATT GAA GAT TTT TGT TTG GAT ATT ATG TTT GAT TTA CCC 1308Arg Ala Ile Ile Glu Asp Phe Cys Leu Asp Ile Met Phe Asp Leu Pro
400 405 410AAG CTT AAA GGA TCG GAA GTG CGT ATC ACT AAA GAT TGT GTT TTA AAA 1356Lys Leu Lys Gly Ser Glu Val Arg Ile Thr Lys Asp Cys Val Leu Lys415 420 425 430CAG GCT GAA CCT TTG ATC ATT GCT AAA ACG CAT TCT AAA ATT CTT CCT T 1405Gln Ala Glu Pro Leu Ile Ile Ala Lys Thr His Ser Lys Ile Leu Pro
435440445 AAGGAACACG CTTATAAATT TAACGATAAA GGATTAGAAA GGG 1448 (2) sequence 1070 data: (i) sequence characteristics: length (A): 446 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear(ii) molecular type: protein (xi) sequence description: sequence 1070Met Asn Glu Thr Leu Tyr Cys Ser Phe Cys Lys Lys Pro Glu Ser Arg 151015 Asp Pro Lys Lys Arg Arg Ile Ile Phe Ala Ser Asn Leu Asn Lys Asp
20 25 30ValCys Val Cys Glu Tyr Cys Ile Asp Val Met His Gly Glu Leu His
35 40 45Lys Tyr Asp Asn Ser Leu Leu Ala Leu Lys Arg Asp Arg Leu Arg Arg
50 55 60Met Glu Ser Ser Ala Tyr Glu Glu Glu Phe Leu Leu Ser Tyr Ile Pro65 70 75 80Ala Pro Lys Glu Leu Lys Ala Val Leu Asp Asn Tyr Val Ile Gly Gln
85 90 95Glu Gln Ala Lys Lys Val Phe Ser Val Ala Val Tyr Asn His Tyr Lys
100 105 110Arg Leu Ser Phe Lys Glu Lys Leu Lys Lys Gln Asp Asn Gln Asp Ser
115 120 125Asn Val Glu Leu Glu His Leu Glu Glu Val Glu Leu Ser Lys Ser Asn
130 135 140Ile Leu Leu Ile Gly Pro Thr Gly Ser Gly Lys Thr Leu Met Ala Gln145 150 155 160Thr Leu Ala Lys His Leu Asp Ile Pro Ile Ala Ile Ser Asp Ala Thr
165 170 175Ser Leu Thr Glu Ala Gly Tyr Val Gly Glu Asp Val Glu Asn Ile Leu
180 185 190Thr Arg Leu Leu Gln Ala Ser Asp Trp Asn Val Gln Lys Ala Gln Lys
195 200 205Gly Ile Val Phe Ile Asp Glu Ile Asp Lys Ile Ser Arg Leu Ser Glu
210 215220Asn Arg Ser Ile Thr Arg Asp Val Ser Gly Glu Gly Val Gln Gln Ala225 230 235 240Leu Leu Lys Ile Val Glu Gly Ser Leu Val Asn Ile Pro Pro Lys Gly
245 250 255Gly Arg Lys His Pro Glu Gly Asn Phe Ile Gln Ile Asp Thr Ser Asp
260 265 270Ile Leu Phe Ile Cys Ala Gly Ala Phe Asp Gly Leu Ala Glu Ile Ile
275 280 285Lys Lys Arg Thr Thr Gln Asn Val Leu Gly Phe Thr Gln Glu Lys Met
290 295 300Ser Lys Lys Glu Gln Glu Ala Ile Leu His Leu Val Gln Thr His Asp305 310 315 320Leu Val Thr Tyr Gly Leu Ile Pro Glu Leu Ile Gly Arg Leu Pro Val
325 330 335Leu Ser Thr Leu Asp Ser Ile Ser Leu Glu Ala Met Val Asp Ile Leu
340 345 350Gln Lys Pro Lys Asn Ala Leu Ile Lys Gln Tyr Gln Gln Leu Phe Lys
355 360 365Met Asp Glu Val Asp Leu Ile Phe Glu Glu Glu Ala Ile Lys Glu Ile
370 375 380Ala Gln Leu Ala Leu Glu Arg Lys Thr Gly Ala Arg Gly Leu Arg Ala385 390 395 400Ile Ile Glu Asp Phe Cys Leu Asp Ile Met Phe Asp Leu Pro Lys Leu
405 410 415Lys Gly Ser Glu Val Arg Ile Thr Lys Asp Cys Val Leu Lys Gln Ala
420 425 430Glu Pro Leu Ile Ile Ala Lys Thr His Ser Lys Ile Leu Pro
435440445 (2) data of SEQ ID No. 1071: (i) sequence characteristics: length (A): 911bp (b) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 858 (D) other information: (xi) Description of the sequence: sequence 1071: AGTGTTAGAA AAAACTTTGC TTTGAAATTT GGC ATG AAA GCA GGC ATT ATT GGT 54
Met Lys Ala Gly Ile Ile Gly
1 5TTA GGG CTT ATG GGG GGG AGT TTA GGG CTA GCC TTG CAA GAA TGG GGG 102Leu Gly Leu Met Gly Gly Ser Leu Gly Leu Ala Leu Gln Glu Trp Gly
10 15 20CGT TTT AAA AGC GTT ATA GGC TAT GAT CAT AAC GCT TTG CAT GCT AAA 150Arg Phe Lys Ser Val Ile Gly Tyr Asp His Asn Ala Leu His Ala Lys
25 30 35TTG GCT TTG ACT TTG GGG CTT GTA GAT GAA TGC GTG GGA TTT GAA AAG 198Leu Ala Leu Thr Leu Gly Leu Val Asp Glu Cys Val Gly Phe Glu Lys40 45 50 55ATT TTA GAA TGC GAT GTG ATT TTT TTG GCC ATT CCG GTT GAG GGC ATC 246Ile Leu Glu Cys Asp Val Ile Phe Leu Ala Ile Pro Val Glu Gly Ile
60 65 70ATT GGA TGT CTG AAA AAA ATG ACC TCT ATC AAA AAA AGC GCG ACC ATT 294Ile Gly Cys Leu Lys Lys Met Thr Ser Ile Lys Lys Ser Ala Thr Ile
75 80 85ATT GAT TTA GGG GGC GCT AAA GCG CAA ATC ATT CGC AAT ATC CCT AAA 342Ile Asp Leu Gly Gly Ala Lys Ala Gln Ile Ile Arg Asn Ile Pro Lys
90 95 100AGC ATT CGT AAG AAT TTC ATC GCT GCG CAC CCC ATG TGC GGG ACA GAG 390Ser Ile Arg Lys Asn Phe Ile Ala Ala His Pro Met Cys Gly Thr Glu
105 110 115TTT TAT GGC CCT AAA GCG AGC GTT AAG GGG CTG TAT GAA AAC GCT CTA 438Phe Tyr Gly Pro Lys Ala Ser Val Lys Gly Leu Tyr Glu Asn Ala Leu120 125 130 135GTG ATA TTG TGC GAT TTA GAA GAT TCA GGG ACT GAG CAA GTA GAG ATC 486Val Ile Leu Cys Asp Leu Glu Asp Ser Gly Thr Glu Gln Val Glu Ile
140 145 150GCT AAA GAA ATC TTT TTA GGC GTT AAA GCG CGC TTG ATT AAA ATG AAA 534Ala Lys Glu Ile Phe Leu Gly Val Lys Ala Arg Leu Ile Lys Met Lys
155 160 165TCC AAT GAG CAT GAC ACC CAT GTG GCT TAT ATC AGC CAT TTA CCC CAT 582Ser Ash Glu His Asp Thr His Val Ala Tyr Ile Ser His Leu Pro His
170 175 180GTT TTG AGC TAT GCG TTA GCC AAT AGC GTT TTA AAG CAA AAC GAC CCA 630Val Leu Ser Tyr Ala Leu Ala Asn Ser Val Leu Lys Gln Asn Asp Pro
185 190 195GAG ATG ATT TTA TCT TTA GCG GGT GGG GGT TTT AGG GAT ATG AGC CGT 678Glu Met Ile Leu Ser Leu Ala Gly Gly Gly Phe Arg Asp Met Ser Arg200 205 210 215CTG TCC AAA AGC TCG CCT TTA ATG TGG AAA GAT ATT TTC AAA CAA AAC 726Leu Ser Lys Ser Ser Pro Leu Met Trp Lys Asp Ile Phe Lys Gln Asn
220 225 230CGA GAC AAT GTC TTA GAA GCG ATT AAA AAA TGC GAA AAA GAA ATC GTG 774Arg Asp Asn Val Leu Glu Ala Ile Lys Lys Cys Glu Lys Glu Ile Val
235 240 245CAA GCT AAG GCG TGG ATA GAA AAT AAC GAT TAT GAA AGC CTT GCA GAA 822Gln Ala Lys Ala Trp Ile Glu Asn Asn Asp Tyr Glu Ser Leu Ala Glu
250 255 260TGG ATG GCG CAA GCG AAC AAA CTC CAG GAG TTC ATG TAAAGTAAAA TGATGT 874Trp Met Ala Gln Ala Asn Lys Leu Gln Glu Phe Met
265270275 AAAATAATTT AAAATTTTTT ATATTGTTGT TTTTAGG 911 (911) (2) data of sequence 1072: (i) sequence characteristics: length (A): 275 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1072: met Lys Ala Gly Ile Ile Gly Leu Gly Leu Met Gly Gly Ser Leu Gly 151015 Leu Ala Leu Gln Glu Trp Gly Arg Phe Lys Ser Val Ile Gly Tyr Asp
20 25 30His Asn Ala Leu His Ala Lys Leu Ala Leu Thr Leu Gly Leu Val Asp
35 40 45Glu Cys Val Gly Phe Glu Lys Ile Leu Glu Cys Asp Val Ile Phe Leu
50 55 60Ala Ile Pro Val Glu Gly Ile Ile Gly Cys Leu Lys Lys Met Thr Ser65 70 75 80Ile Lys Lys Ser Ala Thr Ile Ile Asp Leu Gly Gly Ala Lys Ala Gln
85 90 95Ile Ile Arg Asn Ile Pro Lys Ser Ile Arg Lys Asn Phe Ile Ala Ala
100 105 110His Pro Met Cys Gly Thr Glu Phe Tyr Gly Pro Lys Ala Ser Val Lys
115 120 125Gly Leu Tyr Glu Asn Ala Leu Val Ile Leu Cys Asp Leu Glu Asp Ser
130 135 140Gly Thr Glu Gln Val Glu Ile Ala Lys Glu Ile Phe Leu Gly Val Lys145 150 155 160Ala Arg Leu Ile Lys Met Lys Ser Asn Glu His Asp Thr His Val Ala
165 170 175Tyr Ile Ser His Leu Pro His Val Leu Ser Tyr Ala Leu Ala Asn Ser
180 185 190Val Leu Lys Gln Asn Asp Pro Glu Met Ile Leu Ser Leu Ala Gly Gly
195 200 205Gly Phe Arg Asp Met Ser Arg Leu Ser Lys Ser Ser Pro Leu Met Trp
210 215 220Lys Asp Ile Phe Lys Gln Asn Arg Asp Asn Val Leu Glu Ala Ile Lys225 230 235 240Lys Cys Glu Lys Glu Ile Val Gln Ala Lys Ala Trp Ile Glu Asn Asn
245 250 255Asp Tyr Glu Ser Leu Ala Glu Trp Met Ala Gln Ala Asn Lys Leu Gln
260 265 270Glu Phe Met
275 (2) data on sequence 1073: (i) sequence characteristics: length (A): 304bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 73...267 (D) other information: (xi) Description of the sequence: sequence 1073: AATAATTTAA AATTTTTTAT ATTGTTGTTT TTAGGGGTGC GAGGAGCGAA ATGGGGTATT 60TGGATTGTTT TT ATG GAT TAT AGG CTG TTT CAT ATG GAT AGC ATG GAT TTA 111
Met Asp Tyr Arg Leu Phe His Met Asp Ser Met Asp Leu
1 5 10CCC AGC AAC CAG CAA ACA ACC ATA AGA GAT TAT CTT AAA CCC GGA TCT 159Pro Ser Asn Gln Gln Thr Thr Ile Arg Asp Tyr Leu Lys Pro Gly Ser
15 20 25ATT GTT GTG TTT GCC ATA ATT GTA ATA ATA ATT TCA TCT CAT TTC TCC 207Ile Val Val Phe Ala Ile Ile Val Ile Ile Ile Ser Ser His Phe Ser30 35 40 45AAC GCC TAT AAA ACC CTT ATC GCT TCT AAT AAA AAA CCA GTT TTA AGC 255Asn Ala Tyr Lys Thr Leu Ile Ala Ser Asn Lys Lys ProVal Leu Ser
50 55 60CAT TTA GAA ATT TGATTTCTTA AACCTTTTTA TCAAAAATAC CGGTGTT 304His Leu Glu Ile
65 (2) data of SEQ ID No. 1074: (i) sequence characteristics: length (A): 65 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1074: met Asp Tyr Arg Leu Phe His Met Asp Ser Met Asp Leu Pro Ser Asn 151015 Gln Gln Thr Thr Ile Arg Asp Tyr Leu Lys Pro Gly Ser Ile Val Val
20 25 30Phe Ala Ile Ile Val Ile Ile Ile Ser Ser His Phe Ser Asn Ala Tyr
35 40 45Lys Thr Leu Ile Ala Ser Asn Lys Lys Pro Val Leu Ser His Leu Glu
505560 Ile65 (2) sequence 1075 data: (i) sequence characteristics: length (A): 271bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 237 (D) other information: (xi) Description of the sequence: sequence 1075: AGCTCACATT TTAGAAAAAT ATTTAAAGGG AGA ATG ATG CAA AAT AGC GTT AAA 54
Met Met Gln Asn Ser Val Lys
1 5AAA TTA GAA TAT GAA GAG CGT TTC AAT GAC GCT CTT TTG AAA TTA CAA 102Lys Leu Glu Tyr Glu Glu Arg Phe Asn Asp Ala Leu Leu Lys Leu Gln
10 15 20GCA TGC CAA GAA GAA AAG CAG GTA ACG AGT TGT TTG AAA TGC GAG CAG 150Ala Cys Gln Glu Glu Lys Gln Val Thr Ser Cys Leu Lys Cys Glu Gln
25 30 35GTT TTG AAT TGC AAG ATC CGC AAC AGC TAT GTG GAT GCGGCT TAT GAG 198Val Leu Asn Cys Lys Ile Arg Asn Ser Tyr Val Asp Ala Ala Tyr Glu40 45 50 55AGC ATG AGT TTA GGC GAA CGG GGC GGG TTT GAT TTC AAT TAAATGGGAT TA 249Ser Met Ser Leu Gly Glu Arg Gly Gly Phe Asp Phe Asn
6065 AAATGGCTAG TAATACTACC TT 271 (2) sequence 1076 data: (i) sequence characteristics: length (A): 68 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1076: met Met Gln Asn Ser Val Lys Lys Leu Glu Tyr Glu Glu Arg Phe Asn 151015 Asp Ala Leu Leu Lys Leu Gln Ala Cys Gln Glu Glu Lys Gln Val Thr
20 25 30Ser Cys Leu Lys Cys Glu Gln Val Leu Asn Cys Lys Ile Arg Asn Ser
35 40 45Tyr Val Asp Ala Ala Tyr Glu Ser Met Ser Leu Gly Glu Arg Gly Gly
50 55 60Phe Asp Phe Asn65
(2) Data in SEQ ID No. 1077: (i) sequence characteristics:
(A) length: 572bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 27...524
(D) Other information:
(xi) Description of the sequence: sequence 1077: AAAAGGCTTT TTAAAAGGAC ACACCA ATG AGC GAA CCA TTA GAA ACA TTA GAC 53
Met Ser Glu Pro Leu Glu Thr Leu Asp
1 5AAG GAT AAA CAA GCT ATG AGT GAA GCA ATT AAA AAA GAT ATT GAA AAA 101Lys Asp Lys Gln Ala Met Ser Glu Ala Ile Lys Lys Asp Ile Glu Lys10 15 20 25GAC AAA GAA AAC CTC GCA CGA GTC AAA GCA GAC AAA AAA GTC AAA GCC 149Asp Lys Glu Asn Leu Ala Arg Val Lys Ala Asp Lys Lys Val Lys Ala
30 35 40GAT GAA AGT GAA AAA GGC TAC GAA AAA GAC GAT GAC AAA AAA GCC GAG 197Asp Glu Ser Glu Lys Gly Tyr Glu Lys Asp Asp Asp Lys Lys Ala Glu
45 50 55AAT CTT GAC AAA GAA ATC GCT AAA GAC AAA GCT AGC CCT AAC GAT AAT 245Asn Leu Asp Lys Glu Ile Ala Lys Asp Lys Ala Ser Pro Asn Asp Asn
60 65 70GAG CTT TAT GAA GAG GAC GAT AGA GTT AAA CGA GAC AAA GAA AGA GAC 293Glu Leu Tyr Glu Glu Asp Asp Arg Val Lys Arg Asp Lys Glu Arg Asp
75 80 85GAT GCC TTG CGT GAT AAA GAA AAA GCC AAA GAT GAC GCA TGC ATG GTA 341Asp Ala Leu Arg Asp Lys Glu Lys Ala Lys Asp Asp Ala Cys Met Val90 95 100 105AGA GCG GAC GAT GAC ACC ATA GAG GAC GAT GAG GAA TAT GGT GAT GAT 389Arg Ala Asp Asp Asp Thr Ile Glu Asp Asp Glu Glu Tyr Gly Asp Asp
110 115 120GAT AAG TTA AGA GAC GAA ATA GTC GGT GTT ATG GAG GAG TTA TGC GAT 437Asp Lys Leu Arg Asp Glu Ile Leu Gly Val Met Glu Glu Leu Cys Asp
125 130 135ACC CTT AAT GAT AAC CTT AAC TTC AAA AAA GTC GTC TGT ATG GGC GGT 485Thr Leu Asn Asp Asn Leu Asn Phe Lys Lys Val Val Cys Met Gly Gly
140 145 150AAG GTT TCA ATT GCG TTC AAA TTT CTA ATT TTT TGC TCT TAATCTTTTA GA 536Lys Val Ser Ile Ala Phe Lys Phe Leu Ile Phe Cys Ser
155160165 AAAAATTCAA ACTCTAAGGA TCTATCTTTT CGTTAG 572 (572) (2) sequence 1078 data: (i) sequence characteristics: length (A): 166 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1078: met Ser Glu Pro Leu Glu Thr Leu Asp Lys Asp Lys Gln Ala Met Ser 151015 Glu Ala Ile Lys Lys Asp Ile Glu Lys Asp Lys Glu Asn Leu Ala Arg
20 25 30Val Lys Ala Asp Lys Lys Val Lys Ala Asp Glu Ser Glu Lys Gly Tyr
35 40 45Glu Lys Asp Asp Asp Lys Lys Ala Glu Asn Leu Asp Lys Glu Ile Ala
50 55 60Lys Asp Lys Ala Ser Pro Asn Asp Asn Glu Leu Tyr Glu Glu Asp Asp65 70 75 80Arg Val Lys Arg Asp Lys Glu Arg Asp Asp Ala Leu Arg Asp Lys Glu
85 90 95Lys Ala Lys Asp Asp Ala Cys Met Val Arg Ala Asp Asp Asp Thr Ile
100 105 110Glu Asp Asp Glu Glu Tyr Gly Asp Asp Asp Lys Leu Arg Asp Glu Ile
115 120 125Leu Gly Val Met Glu Glu Leu Cys Asp Thr Leu Asn Asp Asn Leu Asn
130 135 140Phe Lys Lys Val Val Cys Met Gly Gly Lys Val Ser Ile Ala Phe Lys145 150 155 160Phe Leu Ile Phe Cys Ser
165 (2) data of SEQ ID No. 1079: (i) sequence characteristics: length (A): 2327bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 82...2283 (D) other information: (xi) Description of the sequence: sequence 1079: CAACAAGCTA ACCAAAGCAT TGAAGAAGCT TTACAGAATG TCCCGGGTCT GCAAATTAGG 60AATGCGACAG GTGTAGGGGC T ATG CCT ACT ATC CAA ATC CGT GGC TTT GGA 111
Met Pro Thr Ile Gln Ile Arg Gly Phe Gly
1 5 10GCT GGG GGT TCA GGG CAT AGC GAT GCG ACG CTG ATG TTA GTC AAT GGT 159Ala Gly Gly Ser Gly His Ser Asp Ala Thr Leu Met Leu Val Asn Gly
15 20 25ATT CCT GTT TAT ATG GCC CCC TAC GCT CAC ATT GAG CTA GAC ATT TTC 207Ile Pro Val Tyr Met Ala Pro Tyr Ala His Ile Glu Leu Asp Ile Phe
30 35 40CCC GTT ACC TTT CAA GCC ATT GAT CGC ATT GAT GTG ATC AAG GGT GGA 255Pro Val Thr Phe Gln Ala Ile Asp Arg Ile Asp Val Ile Lys Gly Gly
45 50 55GGC AGC GTG CAA TAC GGG CCT AAC ACT TAT GGG GGT ATT GTC AAT ATC 303Gly Ser Val Gln Tyr Gly Pro Asn Thr Tyr Gly Gly Ile Val Asn Ile
60 65 70ATC ACT AAG CCT ATC CCT AAT CAA TGG GAA AAC CAA GCG GCT GAA AGG 351Ile Thr Lys Pro Ile Pro Asn Gln Trp Glu Asn Gln Ala Ala Glu Arg75 80 85 90ATC ACT TAT TGG GCT AAG GCT AGA AAC GCT GGG TTT GCC GCT CCT CCT 399Ile Thr Tyr Trp Ala Lys Ala Arg Asn Ala Gly Phe Ala Ala Pro Pro
95 100 105GAT AAA ACC GGC GAT CCT TCT TTC ATC AAG TCT TTA GGC AAC AAC CTC 447Asp Lys Thr Gly Asp Pro Ser Phe Ile Lys Ser Leu Gly Asn Asn Leu
110 115120CTC TAT AAC ACT TAT GTG AGG AGT GGA GGG ATG ATC AAT AAG CAT GTG 495Leu Tyr Asn Thr Tyr Val Arg Ser Gly Gly Met Ile Asn Lys His Val
125 130 135GGT ATC CAA GCG CAA GCT AAC TGG GTT AGA GGA CAA GGC TTT AGG GAC 543Gly Ile Gln Ala Gln Ala Asn Trp Val Arg Gly Gln Gly Phe Arg Asp
140 145 150AAT AGC CCC TCT AAC ATT TCA AAC TAT TGG CTA GAT GGA GTC TAT GAC 591Asn Ser Pro Ser Asn Ile Ser Asn Tyr Trp Leu Asp Gly Val Tyr Asp155 160 165 170ATC AAT GAA AAC AAT GGG ATT AAA GCC TAT TAC CAA TAC TAC GAT TTT 639Ile Asn Glu Asn Asn Gly Ile Lys Ala Tyr Tyr Gln Tyr Tyr Asp Phe
175 180 185GCT ATC GCT CAA CCA GGA TCA CTC AGC GAG CAA GAT TAC AAA ATA AAC 687Ala Ile Ala Gln Pro Gly Ser Leu Ser Glu Gln Asp Tyr Lys Ile Asn
190 195 200CGC TTC GCT AAT TTG CGC CCC TTA AAC CAA AAA GGC GGG CGT TCA CAA 735Arg Phe Ala Asn Leu Arg Pro Leu Asn Gln Lys Gly Gly Arg Ser Gln
205 210 215CGC TTT GGG GCT GTG TAT GAA AAC CGC TTC GGG GAT TTA GAC AAA GTG 783Arg Phe Gly Ala Val Tyr Glu Asn Arg Phe Gly Asp Leu Asp Lys Val
220 225 230GGC GGG ACT TTT AGC TTC ACT TAC TAT GGG CAG TTG ATG ACT AGG GAT 831Gly Gly Thr Phe Ser Phe Thr Tyr Tyr Gly Gln Leu Met Thr Arg Asp235 240 245 250TTT CAA GTG AGC TCT AGC TAC AAT AGC GCT AAC ATG GTT ACT TGT TTT 879Phe Gln Val Ser Ser Ser Tyr Asn Ser Ala Asn Met Val Thr Cys Phe
255 260 265AGC GAA GCG GCA TGC AGG GCG GCA GGA CTT CCG GCA GGG TAT AAC TTG 927Ser GluAla Ala Cys Arg Ala Ala Gly Leu Pro Ala Gly Tyr Asn Leu
270 275 280GCT GTG CCT TAT TAT GCC ACT AAC TAC AAT GGC TGG GCA GAA GTA GAA 975Ala Val Pro Tyr Tyr Ala Thr Asn Tyr Asn Gly Trp Ala Glu Val Glu
285 290 295AAC CCT GTG CGC TCC ATT AAC AAC GCT TTT GAG CCT AAA GTG AAT TTG 1023Asn Pro Val Arg Ser Ile Asn Asn Ala Phe Glu Pro Lys Val Asn Leu
300 305 310ATC GTC AAT ACC GGG AAA GTC AAG CAA ACC TTT ATC ATG GGC TTG CGT 1071Ile Val Asn Thr Gly Lys Val Lys Gln Thr Phe Ile Met Gly Leu Arg315 320 325 330TTC ATG ACC ACC ACT TTT TTA CAG CGC CAA TAC TTA AAC ACC AAT GAA 1119Phe Met Thr Thr Thr Phe Leu Gln Arg Gln Tyr Leu Asn Thr Asn Glu
335 340 345TGC GCC ACC AAA ACG AGC GGT GAG GGG GCA GGA TTC TTG TGT GAG GGC 1167Cys Ala Thr Lys Thr Ser Gly Glu Gly Ala Gly Phe Leu Cys Glu Gly
350 355 360GCT AAT GTG ATG AGC GGT TGG AAA CCT CAC ATC AAG CAT GGC GTT TAT 1215Ala Asn Val Met Ser Gly Trp Lys Pro His Ile Lys His Gly Val Tyr
365 370 375AGA AAC TGG AAT AAC TGG CGT AAC AAT TAC ACA GCG GTT TAT TTG AGC 1263Arg Asn Trp Asn Asn Trp Arg Asn Asn Tyr Thr Ala Val Tyr Leu Ser
380 385 390GAT CGC ATT GAA GCT TGG GAT GGG CGC TTT TTC ATC GTG CCT GGT TTG 1311Asp Arg Ile Glu Ala Trp Asp Gly Arg Phe Phe Ile Val Pro Gly Leu395 400 405 410CGC TAC GCT TTT GTG CAA TAC AAC AAC GAA AAT GCG TCT AAC TGG ATG 1359Arg Tyr Ala Phe Val Gln Tyr Asn Asn Glu Asn Ala Ser Asn Trp Met
415 420 425CAA ATC CCT GAG AAG GAT TTA AGA AAA ATC AAG CAC ATG AAC AAT TGG 1407Gln Ile Pro Glu Lys Asp Leu Arg Lys Ile Lys His Met Asn Asn Trp
430 435 440ATG CCC TCA ACC AAC ATT GGC TTT ATC CCC GTG CAA GGC GAT CAC AAT 1455Met Pro Ser Thr Asn Ile Gly Phe Ile Pro Val Gln Gly Asp His Asn
445 450 455GTG CTT ACC TAC TTT AAC TAC CAA CGC TCT TTC GTC CCG CCT CAA TTA 1503Val Leu Thr Tyr Phe Asn Tyr Gln Arg Ser Phe Val Pro Pro Gln Leu
460 465 470GAC GTT TTG AGC TAT GGA GGA GCG GAG TAT TTT ACC CAG CAC TTT GAC 1551Asp Val Leu Ser Tyr Gly Gly Ala Glu Tyr Phe Thr Gln His Phe Asp475 480 485 490ACG GTG GAA GCA GGA GCG CGC TAC ACC TAT AAG GAT AAA TTC AGC TTC 1599Thr Val Glu Ala Gly Ala Arg Tyr Thr Tyr Lys Asp Lys Phe Ser Phe
495 500 505AAT GCG GAC TAC TTC AGG ATT TGG GCG CGC GAT TTT GCC ACC GGG CAG 1647Asn Ala Asp Tyr Phe Arg Ile Trp Ala Arg Asp Phe Ala Thr Gly Gln
510 515 520TAT TCA GTC TAT ACA AGC GGT CCC ATG AAG GGT AAT GTG CGC CCC ATT 1695Tyr Ser Val Tyr Thr Ser Gly Pro Met Lys Gly Asn Val Arg Pro Ile
525 530 535AAT GGC TAT TCT CAA GGC GTG GAG CTG GAA TTG TAT TAC AGG CCT ATT 1743Asn Gly Tyr Ser Gln Gly Val Glu Leu Glu Leu Tyr Tyr Arg Pro Ile
540 545 550AGA GGG TTG CAA TTC CAT GCC GCT TTC AAC TAC ATT GAC ACT CGT GTA 1791Arg Gly Leu Gln Phe His Ala Ala Phe Asn Tyr Ile Asp Thr Arg Val555 560 565 570ACC AGC CAT GGC CCT TTA ACC GAC TTG AAC GGG GAT GTG CTA AAA GGG 1839Thr Ser His Gly Pro Leu Thr Asp Leu Asn Gly Asp Val Leu Lys Gly
575 580 585ACT AGC TAT AAC AAG CAT TTC CCT TTT GTA AGC CCT TTC CAA TTC ATT 1887Thr Ser Tyr Asn Lys His Phe Pro Phe Val Ser Pro Phe Gln Phe Ile
590 595 600CTT GAC GCT CGT TAC AAT TGG CGT AAA ACC ACC ATC GGT ATT TCT AGC 1935Leu Asp Ala Arg Tyr Asn Trp Arg Lys Thr Thr Ile Gly Ile Ser Ser
605 610 615TAT TTT TAC AGC CGT GCT TAT AGC GGG ATT AGC AAC AGT GCA GCA GGA 1983Tyr Phe Tyr Ser Arg Ala Tyr Ser Gly Ile Ser Asn Ser Ala Ala Gly
620 625 630GGC TAT TAT GGG ATG CAA TAT TAT AGT GGG GGG AAC AAC TAT GAA AGC 2031Gly Tyr Tyr Gly Met Gln Tyr Tyr Ser Gly Gly Asn Asn Tyr Glu Ser635 640 645 650GTT CTT AAT AGC GGT TAT CAA TGC GAA GCT TGG TGT ATG ACC CAA CAT 2079Val Leu Asn Ser Gly Tyr Gln Cys Glu Ala Trp Cys Met Thr Gln His
655 660 665GAA GGG CTC TTG CCT TGG TAT TGG GTG TGG AAT ATC CAA GTG AGC CAA 2127Glu Gly Leu Leu Pro Trp Tyr Trp Val Trp Asn Ile Gln Val Ser Gln
670 675 680ATT TTC TGG GAA AAC GGG AGA CAC AGA GTT ACA GGA AGC TTG CAA ATC 2175Ile Phe Trp Glu Asn Gly Arg His Arg Val Thr Gly Ser Leu Gln Ile
685 690 695AAT AAT ATC TTC AAC ATG AAG TAT TAT TTT ACA GGG ATT GGC TCT AGC 2223Asn Asn Ile Phe Asn Met Lys Tyr Tyr Phe Thr Gly Ile Gly Ser Ser
700705710 CCT GCA GGC TTG CAA CCT GCG CCT GGA AGA TCG GTT ACA GCG TAT TTG 2271Pro Ala Gly Leu Gln Pro Ala Pro Gly Arg Ser ValThr Ala Tyr Leu 715720725730 AAC TAC ACT TTC TAAAGGCTTT AAAAAGGAGG GGGTTATTGC GCGATGATGA GCCG 2327Asn Tyr Thr Phe (2) sequence 1080 data: (i) sequence characteristics: length (A): 734 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1080: met Pro Thr Ile Gln Ile Arg Gly Phe Gly Ala Gly Gly Ser Gly His 151015 Ser Asp Ala Thr Leu Met Leu Val Asn Gly Ile Pro Val Tyr Met Ala
20 25 30Pro Tyr Ala His Ile Glu Leu Asp Ile Phe Pro Val Thr Phe Gln Ala
35 40 45Ile Asp Arg Ile Asp Val Ile Lys Gly Gly Gly Ser Val Gln Tyr Gly
50 55 60Pro Asn Thr Tyr Gly Gly Ile Val Asn Ile Ile Thr Lys Pro Ile Pro65 70 75 80Asn Gln Trp Glu Asn Gln Ala Ala Glu Arg Ile Thr Tyr Trp Ala Lys
85 90 95Ala Arg Asn Ala Gly Phe Ala Ala Pro Pro Asp Lys Thr Gly Asp Pro
100 105 110Ser Phe Ile Lys Ser Leu Gly Asn Asn Leu Leu Tyr Asn Thr Tyr Val
115 120 125Arg Ser Gly Gly Met Ile Asn Lys His Val Gly Ile Gln Ala Gln Ala
130 135 140Asn Trp Val Arg Gly Gln Gly Phe Arg Asp Asn Ser Pro Ser Asn Ile145 150 155 160Ser Asn Tyr Trp Leu Asp Gly Val Tyr Asp Ile Asn Glu Asn Asn Gly
165 170 175Ile Lys Ala Tyr Tyr Gln Tyr Tyr Asp Phe Ala Ile Ala Gln Pro Gly
180 185 190Ser Leu Ser Glu Gln Asp Tyr Lys Ile Asn Arg Phe Ala Asn Leu Arg
195 200 205Pro Leu Asn Gln Lys Gly Gly Arg Ser Gln Arg Phe Gly Ala Val Tyr
210 215 220Glu Asn Arg Phe Gly Asp Leu Asp Lys Val Gly Gly Thr Phe Ser Phe225 230 235 240Thr Tyr Tyr Gly Gln Leu Met Thr Arg Asp Phe Gln Val Ser Ser Ser
245 250 255Tyr Asn Ser Ala Asn Met Val Thr Cys Phe Ser Glu Ala Ala Cys Arg
260 265 270Ala Ala Gly Leu Pro Ala Gly Tyr Asn Leu Ala Val Pro Tyr Tyr Ala
275 280 285Thr Asn Tyr Asn Gly Trp Ala Glu Val Glu Asn Pro Val Arg Ser Ile
290 295 300Asn Asn Ala Phe Glu Pro Lys Val Asn Leu Ile Val Asn Thr Gly Lys305 310 315 320Val Lys Gln Thr Phe Ile Met Gly Leu Arg Phe Met Thr Thr Thr Phe
325 330 335Leu Gln Arg Gln Tyr Leu Asn Thr Asn Glu Cys Ala Thr Lys Thr Ser
340 345 350Gly Glu Gly Ala Gly Phe Leu Cys Glu Gly Ala Asn Val Met Ser Gly
355 360 365Trp Lys Pro His Ile Lys His Gly Val Tyr Arg Asn Trp Asn Asn Trp
370 375 380Arg Asn Asn Tyr Thr Ala Val Tyr Leu Ser Asp Arg Ile Glu Ala Trp385 390 395 400Asp Gly Arg Phe Phe Ile Val Pro Gly Leu Arg Tyr Ala Phe Val Gln
405 410 415Tyr Asn Asn Glu Asn Ala Ser Asn Trp Met Gln Ile Pro Glu Lys Asp
420 425 430Leu Arg Lys Ile Lys His Met Asn Asn Trp Met Pro Ser Thr Asn Ile
435 440 445Gly Phe Ile Pro Val Gln Gly Asp His Asn Val Leu Thr Tyr Phe Asn
450 455 460Tyr Gln Arg Ser Phe Val Pro Pro Gln Leu Asp Val Leu Ser Tyr Gly465 470 475 480Gly Ala Glu Tyr Phe Thr Gln His Phe Asp Thr Val Glu Ala Gly Ala
485 490 495Arg Tyr Thr Tyr Lys Asp Lys Phe Ser Phe Asn Ala Asp Tyr Phe Arg
500 505 510Ile Trp Ala Arg Asp Phe Ala Thr Gly Gln Tyr Ser Val Tyr Thr Ser
515 520 525Gly Pro Met Lys Gly Asn Val Arg Pro Ile Asn Gly Tyr Ser Gln Gly
530 535 540Val Glu Leu Glu Leu Tyr Tyr Arg Pro Ile Arg Gly Leu Gln Phe His545 550 555 560Ala Ala Phe Asn Tyr Ile Asp Thr Arg Val Thr Ser His Gly Pro Leu
565 570 575Thr Asp Leu Asn Gly Asp Val Leu Lys Gly Thr Ser Tyr Asn Lys His
580 585 590Phe Pro Phe Val Ser Pro Phe Gln Phe Ile Leu Asp Ala Arg Tyr Asn
595 600 605Trp Arg Lys Thr Thr Ile Gly Ile Ser Ser Tyr Phe Tyr Ser Arg Ala
610 615 620Tyr Ser Gly Ile Ser Asn Ser Ala Ala Gly Gly Tyr Tyr Gly Met Gln625 630 635 640Tyr Tyr Ser Gly Gly Asn Asn Tyr Glu Ser Val Leu Asn Ser Gly Tyr
645 650 655Gln Cys Glu Ala Trp Cys Met Thr Gln His Glu Gly Leu Leu Pro Trp
660 665 670Tyr Trp Val Trp Asn Ile Gln Val Ser Gln Ile Phe Trp Glu Asn Gly
675 680 685Arg His Arg Val Thr Gly Ser Leu Gln Ile Asn Asn Ile Phe Asn Met
690 695 700Lys Tyr Tyr Phe Thr Gly Ile Gly Ser Ser Pro Ala Gly Leu Gln Pro705 710 715 720Ala Pro Gly Arg Ser Val Thr Ala Tyr Leu Asn Tyr Thr Phe
725730 (2) sequence 1081 data: (i) sequence characteristics: length (A): 232bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 204 (D) other information: (xi) Description of the sequence: sequence 1081: CATTGGAGAT TGTGCCATTC TTTGATTTTA TCTAAA ATG TCT TTA GGG GCA GTG 54
Met Ser Leu Gly Ala Val
1 5ATT AAG CTT ATT TTT TGT TAT AAA TTA GAG GGG GTA ATA TTA GAT TTA 102Ile Lys Leu Ile Phe Cys Tyr Lys Leu Glu Gly Val Ile Leu Asp Leu
10 15 20AAG CGC ATC AAT TTC AAA TCC TAT TAT CCC AAT AAT AAA AAT GCA TTA 150Lys Arg Ile Asn Phe Lys Ser Tyr Tyr Pro Asn Asn Lys Asn Ala Leu
25 30 35TTT ATC AAC AAT AAA AAA ATC CAT TAT CTA GTG CCT CAA AGG TTC ATA 198Phe Ile Asn Asn Lys Lys Ile His Tyr Leu Val Pro Gln Arg Phe Ile
404550 TTG CTT TAAACTTGCT ATGGACGATT AGAAATCG 232Leu 55 (2) sequence 1082 data: (i) sequence characteristics: length (A): 56 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1082: met Ser Leu Gly Ala Val Ile Lys Leu Ile Phe Cys Tyr Lys Leu Glu 151015 Gly Val Ile Leu Asp Leu Lys Arg Ile Asn Phe Lys Ser Tyr Tyr Pro
20 25 30Asn Asn Lys Asn Ala Leu Phe Ile Asn Asn Lys Lys Ile His Tyr Leu
35 40 45Val Pro Gln Arg Phe Ile Leu Leu
5055 (2) sequence 1083 data: (i) sequence characteristics: length (A): 1142bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1094 (D) other information: (xi) Description of the sequence: sequence 1083: CTTTTAGAAT TAGGGCTTAA AGC ATG AAA GCT AGT ATT TAT GAT TTC ACT CTA 53
Met Lys Ala Ser Ile Tyr Asp Phe Thr Leu
1 5 10AAG GAA TTG AGC CAG CTT TTA AAA CCA AGC TTT AGG GCT AAA CAG CTT 101Lys Glu Leu Ser Gln Leu Leu Lys Pro Ser Phe Arg Ala Lys Gln Leu
15 20 25TAT TTG TGG CTC TAT GCG AAG TAT AAA ACA AGC TTT AAG GAC ATG CAA 149Tyr Leu Trp Leu Tyr Ala Lys Tyr Lys Thr Ser Phe Lys Asp Met Gln
30 35 40AAT AAT TTT TCA AAA GAT TTT ATC GCT TAT TTG GAG CGA GAA TTT GCT 197Asn Asn Phe Ser Lys Asp Phe Ile Ala Tyr Leu Glu Arg Glu Phe Ala
45 50 55TTG CGC ACG ATA GAA ATC ACG CAT GTG AGG GAG AGC GTT GAT GGC TCT 245Leu Arg Thr Ile Glu Ile ThrHis Val Arg Glu Ser Val Asp Gly Ser
60 65 70AAA AAA TAC CTT TTT AAA TCT TTA AGA GAC AAC CAC ACT TTT GAA GCG 293Lys Lys Tyr Leu Phe Lys Ser Leu Arg Asp Asn His Thr Phe Glu Ala75 80 85 90GTG TTG TTG AAA ATG AAG GAT AAA AAG ATT GAT GCA GAA ACG AAC GCT 341Val Leu Leu Lys Met Lys Asp Lys Lys Ile Asp Ala Glu Thr Asn Ala
95 100 105ATT TTA GAG AGG GAA AAA TAC ACC GTA TGC GTG TCT TGT CAA ATC GGC 389Ile Leu Glu Arg Glu Lys Tyr Thr Val Cys Val Ser Cys Gln Ile Gly
110 115 120TGT CAA GTG GGT TGC TCG TTT TGT TTC ACT CAA AAA GGC GGT TTT GTA 437Cys Gln Val Gly Cys Ser Phe Cys Phe Thr Gln Lys Gly Gly Phe Val
125 130 135AGG AAC TTA AAA GCG AGC GAG ATC ATC CAA CAA GCC CTA CTC ATT AAA 485Arg Asn Leu Lys Ala Ser Glu Ile Ile Gln Gln Ala Leu Leu Ile Lys
140 145 150GAA GAC AAC AAC CTC CCC CTT GAA AAA GCG CTC AAC ATT GTT TTT ATG 533Glu Asp Asn Asn Leu Pro Leu Glu Lys Ala Leu Asn Ile Val Phe Met155 160 165 170GGA ATG GGC GAG CCT TTA AAC AAT TTA GAT GAG GTG TGT AAA GCG ATT 581Gly Met Gly Glu Pro Leu Asn Asn Leu Asp Glu Val Cys Lys Ala Ile
175 180 185GAG ATT TTC AAT ACC GGC ATG CAA ATT TCG CCT AAA AGA ATC ACC ATT 629Glu Ile Phe Asn Thr Gly Met Gln Ile Ser Pro Lys Arg Ile Thr He
190 195 200TCC ACT AGC GGC GTA GCC GAT AAA ATC CCT ATT TTA GCG GGC AAA AAC 677Ser Thr Ser Gly Val Ala Asp Lys Ile Pro Ile Leu Ala Gly Lys Asn
205210 215TTA GGC GTG CAA TTA GCC ATA TCC TTA CAC GCC GTA GAT GAC AAA ACG 725Leu Gly Val Gln Leu Ala Ile Ser Leu His Ala Val Asp Asp Lys Thr
220 225 230CGC TCG TCT TTA ATG CCC TTG AAT AAA AAA TAC AAT ATT GAA TGC GTT 773Arg Ser Ser Leu Met Pro Leu Asn Lys Lys Tyr Asn Ile Glu Cys Val235 240 245 250TTG AAT GAA GTG AGG AAA TGG CCT TTA GAG CAG CGC AAA AGA GTG ATG 821Leu Asn Glu Val Arg Lys Trp Pro Leu Glu Gln Arg Lys Arg Val Met
255 260 265TTT GAA TAC CTT TTG ATC AAA GAT TTG AAC GAT AGC CTA GAC TGC GCT 869Phe Glu Tyr Leu Leu Ile Lys Asp Leu Asn Asp Ser Leu Asp Cys Ala
270 275 280AAA AAA CTT TTA AAA CTT TTA AAC GGC ATT AAA TCC AAA GTG AAT TTG 917Lys Lys Leu Leu Lys Leu Leu Asn Gly Ile Lys Ser Lys Val Asn Leu
285 290 295ATC TTA TTC AAC CCG CAT GAA GGC TCT AAG TTT GAA CGC CCT AGC TTA 965Ile Leu Phe Asn Pro His Glu Gly Ser Lys Phe Glu Arg Pro Ser Leu
300 305 310GAG AAC GCT AGA ATG TTT GCG GAT TTT TTA AAC TCT AAA GGC TTA TTA 1013Glu Asn Ala Arg Met Phe Ala Asp Phe Leu Asn Ser Lys Gly Leu Leu315 320 325 330TGC ACC ATT AGA GAG TCT AAA GCC TTG GAT ATT GAA GCG GCT TGC GGG 1061Cys Thr Ile Arg Glu Ser Lys Ala Leu Asp Ile Glu Ala Ala Cys Gly
335 340 345CAG TTG AGG GAG AAA AAA CTC TCT CAG CAA ATT TGAAAACTTT TTTGTGGTGT 1114Gln Leu Arg Glu Lys Lys Leu Ser Gln Gln Ile
350355 TTGTCTTTTT TCTAATGGGG GGTGTTGG 1142 (2) sequence 1084 data: (i) sequence characteristics: length (A): 357amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1084: met Lys Ala Ser Ile Tyr Asp Phe Thr Leu Lys Glu Leu Ser Gln Leu 151015 Leu Lys Pro Ser Phe Arg Ala Lys Gln Leu Tyr Leu Trp Leu Tyr Ala
20 25 30Lys Tyr Lys Thr Ser Phe Lys Asp Met Gln Asn Asn Phe Ser Lys Asp
35 40 45Phe Ile Ala Tyr Leu Glu Arg Glu Phe Ala Leu Arg Thr Ile Glu Ile
50 55 60Thr His Val Arg Glu Ser Val Asp Gly Ser Lys Lys Tyr Leu Phe Lys65 70 75 80Ser Leu Arg Asp Asn His Thr Phe Glu Ala Val Leu Leu Lys Met Lys
85 90 95Asp Lys Lys Ile Asp Ala Glu Thr Asn Ala Ile Leu Glu Arg Glu Lys
100 105 110Tyr Thr Val Cys Val Ser Cys Gln Ile Gly Cys Gln Val Gly Cys Ser
115 120 125Phe Cys Phe Thr Gln Lys Gly Gly Phe Val Arg Asn Leu Lys Ala Ser
130 135 140Glu Ile Ile Gln Gln Ala Leu Leu Ile Lys Glu Asp Asn Asn Leu Pro145 150 155 160Leu Glu Lys Ala Leu Asn Ile Val Phe Met Gly Met Gly Glu Pro Leu
165 170 175Asn Asn Leu Asp Glu Val Cys Lys Ala Ile Glu Ile Phe Asn Thr Gly
180 185 190Met Gln Ile Ser Pro Lys Arg Ile Thr Ile Ser Thr Ser Gly Val Ala
195 200 205Asp Lys Ile Pro Ile Leu Ala Gly Lys Asn Leu Gly Val Gln Leu Ala
210 215 220Ile Ser Leu His Ala Val Asp Asp Lys Thr Arg Ser Ser Leu Met Pro225 230 235 240Leu Asn Lys Lys Tyr Asn Ile Glu Cys Val Leu Asn Glu Val Arg Lys
245 250 255Trp Pro Leu Glu Gln Arg Lys Arg Val Met Phe Glu Tyr Leu Leu Ile
260 265 270Lys Asp Leu Asn Asp Ser Leu Asp Cys Ala Lys Lys Leu Leu Lys Leu
275 280 285Leu Asn Gly Ile Lys Ser Lys Val Asn Leu Ile Leu Phe Asn Pro His
290 295 300Glu Gly Ser Lys Phe Glu Arg Pro Ser Leu Glu Asn Ala Arg Met Phe305 310 315 320Ala Asp Phe Leu Asn Ser Lys Gly Leu Leu Cys Thr Ile Arg Glu Ser
325 330 335Lys Ala Leu Asp Ile Glu Ala Ala Cys Gly Gln Leu Arg Glu Lys Lys
340 345 350Leu Ser Gln Gln Ile
355 (2) sequence 1085 data: (i) sequence characteristics: length (A): 990bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 987 (D) other information: (xi) Description of the sequence: sequence 1085: ATG CCC ATT CTT TTT GAT TGT AAC GCT ATT GCT TCA CAA GTT TTA AAA 48Met Pro Ile Leu Phe Asp Cys Asn Ala Ile Ala Ser Gln Val Leu Lys 151015 GAT GAA GCG AGC GCG CTT TTA GAA AGC GTT GGA CAA TTC CAA AAA CCC 96Asp Glu Ala Ser Ala Leu Leu Glu Ser Val Gly Gln Phe Gln Lys Pro
20 25 30AAC GAT TTA GAA GCG ATT GTC AAA CTC ATT TTA AAA AGC CAA GAA AAT 144Asn Asp Leu Glu Ala Ile Val Lys Leu Ile Leu Lys Ser Gln Glu Asn
35 40 45GGG GGT AAG CTT GTG ATA GTG GGT GTG GGT AAG AGC GCT TTA GTG GCG 192Gly Gly Lys Leu Val Ile Val Gly Val Gly Lys Ser Ala Leu Val Ala
50 55 60CAA AAA ATC GTT GCT TCC ATG CTA AGC ACC GGT AAC AGG AGC GCG TTT 240Gln Lys Ile Val Ala Ser Met Leu Ser Thr Gly Asn Arg Ser Ala Phe65 70 75 80TTA CAC CCC ACA GAA GCC ATG CAT GGG GAT TTG GGC ATG GTG GAA AAA 288Leu His Pro Thr Glu Ala Met His Gly Asp Leu Gly Met Val Glu Lys
85 90 95AAC GAT GTG GTT TTA ATG ATT AGC TAT GGG GGC GAG TCT TTA GAA TTA 336Asn Asp Val Val Leu Met Ile Ser Tyr Gly Gly Glu Ser Leu Glu Leu
100 105 110TTG AAT CTG GTG AGC CAT TTA AAA CGC TTG AGC CAT AAA ATC ATC ACT 384Leu Asn Leu Val Ser His Leu Lys Arg Leu Ser His Lys Ile Ile Thr
115 120 125TTC ACT AAA AGC CCT AAT AGC TCG CTC TCT AAA CTC GGC GAT TAT TAT 432Phe Thr Lys Ser Pro Asn Ser Ser Leu Ser Lys Leu Gly Asp Tyr Tyr
130 135 140TTG AGC TTG AAA ATT CAA AAA GAA GCT TGC CCG ATT AAC ACC GCT CCA 480Leu Ser Leu Lys Ile Gln Lys Glu Ala Cys Pro Ile Asn Thr Ala Pro145 150 155 160ACG ACT TCT ACC ACC CTA ACT CTA GCG TTA GGC GAT GTT TTA ATG GCA 528Thr Thr Ser Thr Thr Leu Thr Leu Ala Leu Gly Asp Val Leu Met Ala
165 170 175TGC TTG ATG CGA GCG AAA AAC TTT AGC CAA GAA GAT TTT GCC TCC TTT 576Cys Leu Met Arg Ala Lys Asn Phe Ser Gln Glu Asp Phe Ala Ser Phe
180 185 190CAT CCG GGC GGG CTT TTA GGC AAA AAA CTT TTT GTC AAG GTT AAA GAT 624His Pro Gly Gly Leu Leu Gly Lys Lys Leu Phe Val Lys Val Lys Asp
195 200 205TTA CTG CAA ACC ACG AAC CTC CCC CTA ATC GCT CCT AGC ACA AGT TTT 672Leu Leu Gln Thr Thr Asn Leu Pro Leu Ile Ala Pro Ser Thr Ser Phe
210 215 220AAA GAC GCG CTC ATA GAA ATG AGT GAA AAA CGC TTA GGC AGC GCG ATT 720Lys Asp Ala Leu Ile Glu Met Ser Glu Lys Arg Leu Gly Ser Ala Ile225 230 235 240TTA GTC AAT GAA GCT AAC GAG CTT GTG GGG GTG TTA AGC GAT GGC GAT 768Leu Val Asn Glu Ala Asn Glu Leu Val Gly Val Leu Ser Asp Gly Asp
245 250 255GTC CGT AGG GCG TTA TTA AAA GGG GTG AGT TTA AAG AGC GAA GTG AGG 816Val Arg Arg Ala Leu Leu Lys Gly Val Ser Leu Lys Ser Glu Val Arg
260 265 270CAT TTT GCC ACT TTA AAA CCT AAA AGC TTT AAG AAT TTA GAC GCT CTT 864His Phe Ala Thr Leu Lys Pro Lys Ser Phe Lys Asn Leu Asp Ala Leu
275 280 285CTT TTA GAA GCG TTG GAA TTT TTA GAG CGC CAT AAG ATC CAG CTT TTA 912Leu Leu Glu Ala Leu Glu Phe Leu Glu Arg His Lys Ile Gln Leu Leu
290 295 300GTG TGC GTA GAT GAT CAT AAT AAG GTT TTA GGG GTC TTG CAC TTG CAC 960Val Cys Val Asp Asp His Asn Lys Val Leu Gly Val Leu His Leu His305 310 315 320CAA CTT TTA GAA TTA GGG CTT AAA GCA TGA 990Gln Leu Leu Glu Leu Gly Leu Lys Ala
325 (2) sequence 1086 data: (i) sequence characteristics: length (A): 329 amino acid (B) types: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1086: met Pro Ile Leu Phe Asp Cys Asn Ala Ile Ala Ser Gln Val Leu Lys 151015 Asp Glu Ala Ser Ala Leu Leu Glu Ser Val Gly Gln Phe Gln Lys Pro
20 25 30Asn Asp Leu Glu Ala Ile Val Lys Leu Ile Leu Lys Ser Gln Glu Asn
35 40 45Gly Gly Lys Leu Val Ile Val Gly Val Gly Lys Ser Ala Leu Val Ala
50 55 60Gln Lys Ile Val Ala Ser Met Leu Ser Thr Gly Asn Arg Ser Ala Phe65 70 75 80Leu His Pro Thr Glu Ala Met His Gly Asp Leu Gly Met Val Glu Lys
85 90 95Asn Asp Val Val Leu Met Ile Ser Tyr Gly Gly Glu Ser Leu Glu Leu
100 105 110Leu Asn Leu Val Ser His Leu Lys Arg Leu Ser His Lys Ile Ile Thr
115 120 125Phe Thr Lys Ser Pro Asn Ser Ser Leu Ser Lys Leu Gly Asp Tyr Tyr
130 135 140Leu Ser Leu Lys Ile Gln Lys Glu Ala Cys Pro Ile Asn Thr Ala Pro145 150 155 160Thr Thr Ser Thr Thr Leu Thr Leu Ala Leu Gly Asp Val Leu Met Ala
165 170 175Cys Leu Met Arg Ala Lys Asn Phe Ser Gln Glu Asp Phe Ala Ser Phe
180 185 190His Pro Gly Gly Leu Leu Gly Lys Lys Leu Phe Val Lys Val Lys Asp
195 200 205Leu Leu Gln Thr Thr Asn Leu Pro Leu Ile Ala Pro Ser Thr Ser Phe
210 215 220Lys Asp Ala Leu Ile Glu Met Ser Glu Lys Arg Leu Gly Ser Ala Ile225 230 235 240Leu Val Asn Glu Ala Asn Glu Leu Val Gly Val Leu Ser Asp Gly Asp
245 250 255Val Arg Arg Ala Leu Leu Lys Gly Val Ser Leu Lys Ser Glu Val Arg
260 265 270His Phe Ala Thr Leu Lys Pro Lys Ser Phe Lys Asn Leu Asp Ala Leu
275 280 285Leu Leu Glu Ala Leu Glu Phe Leu Glu Arg His Lys Ile Gln Leu Leu
290 295 300Val Cys Val Asp Asp His Asn Lys Val Leu Gly Val Leu His Leu His305 310 315 320Gln Leu Leu Glu Leu Gly Leu Lys Ala
325 (2) sequence 1087 data: (i) sequence characteristics: length (A): 991bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 939 (D) other information: (xi) Description of the sequence: sequence 1087: TCCTTAAAAC ATTTGAAGTA TAATACACTC TTATGGTCAA ATATTAAGTT TAGGAAAAGC 60TGC ATG TGG AGT TTC ATT CAA AAA ATC TTT AAG GCT TTA ATC ATC GCA 108
Met Trp Ser Phe Ile Gln Lys Ile Phe Lys Ala Leu Ile Ile Ala
1 5 10 15CCT TTA GAT TTT ATC ACG AAG TAT TTC AAG TCG TTT GTG CTG TTA CTC 156Pro Leu Asp Phe Ile Thr Lys Tyr Phe Lys Ser Phe Val Leu Leu Leu
20 25 30ATT GTA TTA GTC TTT TTT AGC GCT AAA GAA AGC GCG CCA AGC GCC CCG 204Ile Val Leu Val Phe Phe Ser Ala Lys Glu Ser Ala Pro Ser Ala Pro
35 40 45CCT AAT CTC GCT AAA CTC TAT TTA AAT GGG GCG ATT TTT AGC ACC GAG 252Pro Asn Leu Ala Lys Leu Tyr Leu Asn Gly Ala Ile Phe Ser Thr Glu
50 55 60GAT TTT GAC AAA GAA GTG GAT AAA ATC CTA AAA ACC CCT AGC ATT AAG 300Asp Phe Asp Lys Glu Val Asp Lys Ile Leu Lys Thr Pro Ser Ile Lys
65 70 75GGC GTT TTG CTT TTG ATT GAC TCT CCT GGT GGG GCG GTG TCA GCG AGC 348Gly Val Leu Leu Leu Ile Asp Ser Pro Gly Gly Ala Val Ser Ala Ser80 85 90 95GTG GAA TTG AGC GAA AAA ATC GCT GAT TTG AAG CAA AAA ATG CCC GTT 396Val Glu Leu Ser Glu Lys Ile Ala Asp Leu Lys Gln Lys Met Pro Val
100 105 110TTA GCG TAT GCT AGG GGG GTT ATG GCG AGC GGG AGC TAT TAT GCG GGC 444Leu Ala Tyr Ala Arg Gly Val Met Ala Ser Gly Ser Tyr Tyr Ala Gly
115 120 125ATG CAA GCG AGC GAA GTT TAT GCC TCT AAA GCG AGT TTG ATA GGA TCC 492Met Gln Ala Ser Glu Val Tyr Ala Ser Lys Ala Ser Leu Ile Gly Ser
130 135 140ATT GGG GTG ATT TTT TCA GGT GCG AAT GTG GAA AAT TTG CTC AAT AAA 540Ile Gly Val Ile Phe Ser Gly Ala Asn Val Glu Asn Leu Leu Asn Lys
145 150 155GTC GGC GTA GCC ACT CAA GGC GTG CAT GCG GGC GAA TAC AAA GAA ATA 588Val Gly Val Ala Thr Gln Gly Val His Ala Gly Glu Tyr Lys Glu Ile160 165 170 175GGC ACT TTC ACC AGA GCG TGG AAA CCC AAC GAA AAA GAT TTT TTG CAA 636Gly Thr Phe Thr Arg Ala Trp Lys Pro Asn Glu Lys Asp Phe Leu Gln
180 185190AAT TTA GTC AAT GAG CAA TAC CAA ATG TTT GTG AAT GAT GTC GCA AAA 684Asn Leu Val Asn Glu Gln Tyr Gln Met Phe Val Asn Asp Val Ala Lys
195 200 205GCT AGG AAA TTA GAC GCT AAG GAT TAT AAG GAT TTT GCT GAA GGG AAG 732Ala Arg Lys Leu Asp Ala Lys Asp Tyr Lys Asp Phe Ala Glu Gly Lys
210 215 220GTC TTT AGC GCT CAA AAG GCT CTG AAA TTA AAA CTC ATT GAT AAA ATC 780
Val Phe Ser Ala Gln Lys Ala Leu Lys Leu Lys Leu Ile Asp Lys Ile
225 230 235AGC ACG ATT AAG CAA GCG CAA GAT CGC TTA ATG GAA TTG AGT AAG GTT 828Ser Thr Ile Lys Gln Ala Gln Asp Arg Leu Met Glu Leu Ser Lys Val240 245 250 255AAA AAA GCT TAT TGG CTA GAA AAA AGC CCT ATG GAG CGC TTC ATT GAA 876Lys Lys Ala Tyr Trp Leu Glu Lys Ser Pro Met Glu Arg Phe Ile Glu
260 265 270AAA GCC ACG CAA TCA GCC ACA AAC ATC ATC ACA CAA GCC TTT GGC TAT 924Lys Ala Thr Gln Ser Ala Thr Asn Ile Ile Thr Gln Ala Phe Gly Tyr
275 280 285CAA TTA TTA ATG AGA TAAAGATGTT AGAATTTATT TTAAAAATTC AAGCTAGAGA C 980Gln Leu Leu Met Arg
290TCTAAAGGCT T991 (2) sequence 1088 data: (i) sequence characteristics: length (A): 292 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1088: met Trp Ser Phe Ile Gln Lys Ile Phe Lys Ala Leu Ile Ile Ala Pro 151015 Leu Asp Phe Ile Thr Lys Tyr Phe Lys Ser Phe Val Leu Leu Leu Ile
20 25 30Val Leu Val Phe Phe Ser Ala Lys Glu Ser Ala Pro Ser Ala Pro Pro
35 40 45Asn Leu Ala Lys Leu Tyr Leu Asn Gly Ala Ile Phe Ser Thr Glu Asp
50 55 60Phe Asp Lys Glu Val Asp Lys Ile Leu Lys Thr Pro Ser Ile Lys Gly65 70 75 80Val Leu Leu Leu Ile Asp Ser Pro Gly Gly Ala Val Ser Ala Ser Val
85 90 95Glu Leu Ser Glu Lys Ile Ala Asp Leu Lys Gln Lys Met Pro Val Leu
100 105 110Ala Tyr Ala Arg Gly Val Met Ala Ser Gly Ser Tyr Tyr Ala Gly Met
115 120 125Gln Ala Ser Glu Val Tyr Ala Ser Lys Ala Ser Leu Ile Gly Ser Ile
130 135 140Gly Val Ile Phe Ser Gly Ala Asn Val Glu Asn Leu Leu Asn Lys Val145 150 155 160Gly Val Ala Thr Gln Gly Val His Ala Gly Glu Tyr Lys Glu Ile Gly
165 170 175Thr Phe Thr Arg Ala Trp Lys Pro Asn Glu Lys Asp Phe Leu Gln Asn
180 185 190Leu Val Asn Glu Gln Tyr Gln Met Phe Val Asn Asp Val Ala Lys Ala
195 200 205Arg Lys Leu Asp Ala Lys Asp Tyr Lys Asp Phe Ala Glu Gly Lys Val
210 215 220Phe Ser Ala Gln Lys Ala Leu Lys Leu Lys Leu Ile Asp Lys Ile Ser225 230 235 240Thr Ile Lys Gln Ala Gln Asp Arg Leu Met Glu Leu Ser Lys Val Lys
245 250 255Lys Ala Tyr Trp Leu Glu Lys Ser Pro Met Glu Arg Phe Ile Glu Lys
260 265 270Ala Thr Gln Ser Ala Thr Asn Ile Ile Thr Gln Ala Phe Gly Tyr Gln
275 280 285Leu Leu Met Arg
290 (2) sequence 1089 data: (i) sequence characteristics: length (A): 1114bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1050 (D) other information: (xi) Description of the sequence: sequence 1089: CGAGCTATCA CAACAAATCA ATTTGTAGGA ACAAGC ATG TTT TTT AAA ACT TAT 54
Met Phe Phe Lys Thr Tyr
1 5CAA AAA TTA TTG GGT GCG AGC TGT TTG ACG TTG TAT TTA GCG GGC TGT 102Gln Lys Leu Leu Gly Ala Ser Cys Leu Thr Leu Tyr Leu Ala Gly Cys
10 15 20GGG AGT GAT AGT AGC GAG CCA TTG GTG GGA ATT GAA AAA AAT AGC TTC 150Gly Ser Asp Ser Ser Glu Pro Leu Val Gly Ile Glu Lys Asn Ser Phe
25 30 35AAT TCT ACC GTG AAA ATC ATT TCT AAA ACC GAC AAC ATA GAA ATC CAA 198Asn Ser Thr Val Lys Ile Ile Ser Lys Thr Asp Asn Ile Glu Ile Gln
40 45 50GAC TTG AAG CTC AAT CGT GGC AAT TGT GAG CAT GAT CAA AAT TTC TTG 246Asp Leu Lys Leu Asn Arg Gly Asn Cys Glu His Asp Gln Asn Phe Leu55 60 65 70GTA AAG TTA ATC CAA GAA ACA GCC AAT ACA TAC CTG TTT GCA TCA GAA 294Val Lys Leu Ile Gln Glu Thr Ala Asn Thr Tyr Leu Phe Ala Ser Glu
75 80 85AAA GAA AAA GCG ATC AAA AAC CAC CAA GCA AAA ATC GCA AGA CTT CAA 342Lys Glu LysAla Ile Lys Asn His Gln Ala Lys Ile Ala Arg Leu Gln
90 95 100AAA GAT TTA GAA GAA CTC ACA CAG CAT GTG CAA CAA TCC AAT AAT CTT 390Lys Asp Leu Glu Glu Leu Thr Gln His Val Gln Gln Ser Asn Asn Leu
105 110 115GAT AAA TTG TTA GAA AAT GGA GGA CTA TTC GTT AGT GGC CAT GAT TAT 438Asp Lys Leu Leu Glu Asn Gly Gly Leu Phe Val Ser Gly His Asp Tyr
120 125 130AAA TAT ACA AAA GAT GAT AAC CCA ATA TAT GTT GTT AAG AGG ATG CTT 486Lys Tyr Thr Lys Asp Asp Asn Pro Ile Tyr Val Val Lys Arg Met Leu135 140 145 150GAT AAC CTT GAT AGC TAT AAA TAT GAA TCA GAC GAC GTG CTA GAC GTG 534Asp Asn Leu Asp Ser Tyr Lys Tyr Glu Ser Asp Asp Val Leu Asp Val
155 160 165CCA TAT GAG AAG CTA TTG GAA ATA AGC ATT GCT ATT GAA GAC ACT AAA 582Pro Tyr Glu Lys Leu Leu Glu Ile Ser Ile Ala Ile Glu Asp Thr Lys
170 175 180AAC CCC AAA GAC TAC CCT TAT ATC AAC CTT AAA GAA CTC AAA AAA TTA 630Asn Pro Lys Asp Tyr Pro Tyr Ile Asn Leu Lys Glu Leu Lys Lys Leu
185 190 195ATA GAT AGT ATT ATT GAT GAT CAT GGT TAT ATG GCC GAT GGC TTT TTG 678Ile Asp Ser Ile Ile Asp Asp His Gly Tyr Met Ala Asp Gly Phe Leu
200 205 210AAT GAA TAT TCT AAT AGG GTA TCA AAA AAA GGT CTC CAA ATC CTT GCT 726Asn Glu Tyr Ser Asn Arg Val Ser Lys Lys Gly Leu Gln Ile Leu Ala215 220 225 230AAA CTA AAA TCC ATG TGG CCT AGC GTA GGG AAA TTT TAT TTC GCC TCT 774Lys Leu Lys Ser Met Trp Pro Ser Val Gly Lys Phe Tyr Phe Ala Ser
235 240 245TTG AAA GAG GCT ATC CCA AGG CAT GCC AAA GAA GTT ACT GAC AAG ATG 822Leu Lys Glu Ala Ile Pro Arg His Ala Lys Glu Val Thr Asp Lys Met
250 255 260ATT AGC TCT GAA GAA AAA TCT ATC AAA GCC AAT CAA GTC AAA CTC ACT 870Ile Ser Ser Glu Glu Lys Ser Ile Lys Ala Asn Gln Val Lys Leu Thr
265 270 275GAA GCG AAG CAA GAT ATT GAC AAA ATG GAA AAA ATC ATT AAA GAT TTA 918Glu Ala Lys Gln Asp Ile Asp Lys Met Glu Lys Ile Ile Lys Asp Leu
280 285 290GAA AGC AAG AAA AAC ACC TTA TCA GTG TAT TTA AAA TTT GGA GAA AGT 966Glu Ser Lys Lys Asn Thr Leu Ser Val Tyr Leu Lys Phe Gly Glu Ser295 300 305 310TTC ACA GCG CAT TAT AAG TGT CAA AAT CTC ATA GAA GTT GGA GTC AAA 1014Phe Thr Ala His Tyr Lys Cys Gln Asn Leu Ile Glu Val Gly Val Lys
315 320 325ACC GAT AAA GGC TCC TGG ACT TTC AAC TTT AAC AGA TAAATCAGGC AAATAT 1066Thr Asp Lys Gly Ser Trp Thr Phe Asn Phe Asn Arg
330 335GGACAATAGC ACAGACAGAG CAAAAATCCT TATAGAAGAG CTTAAAAT 1114
(2) Data of sequence 1090:
(i) sequence characteristics:
(A) length: 338 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1090: met Phe Phe Lys Thr Tyr Gln Lys Leu Leu Gly Ala Ser Cys Leu Thr 151015 Leu Tyr Leu Ala Gly Cys Gly Ser Asp Ser Ser Glu Pro Leu Val Gly
20 25 30Ile Glu Lys Asn Ser Phe Asn Ser Thr Val Lys Ile Ile Ser Lys Thr
35 40 45Asp Asn Ile Glu Ile Gln Asp Leu Lys Leu Asn Arg Gly Asn Cys Glu
50 55 60His Asp Gln Asn Phe Leu Val Lys Leu Ile Gln Glu Thr Ala Asn Thr65 70 75 80Tyr Leu Phe Ala Ser Glu Lys Glu Lys Ala Ile Lys Asn His Gln Ala
85 90 95Lys Ile Ala Arg Leu Gln Lys Asp Leu Glu Glu Leu Thr Gln His Val
100 105 110Gln Gln Ser Asn Asn Leu Asp Lys Leu Leu Glu Asn Gly Gly Leu Phe
115 120 125Val Ser Gly His Asp Tyr Lys Tyr Thr Lys Asp Asp Asn Pro Ile Tyr
130 135 140Val Val Lys Arg Met Leu Asp Asn Leu Asp Ser Tyr Lys Tyr Glu Ser145 150 155 160Asp Asp Val Leu Asp Val Pro Tyr Glu Lys Leu Leu Glu Ile Ser Ile
165 170 175Ala Ile Glu Asp Thr Lys Asn Pro Lys Asp Tyr Pro Tyr Ile Asn Leu
180 185 190Lys Glu Leu Lys Lys Leu Ile Asp Ser Ile Ile Asp Asp His Gly Tyr
195 200 205Met Ala Asp Gly Phe Leu Asn Glu Tyr Ser Asn Arg Val Ser Lys Lys
210 215 220Gly Leu Gln Ile Leu Ala Lys Leu Lys Ser Met Trp Pro Ser Val Gly225 230 235240Lys Phe Tyr Phe Ala Ser Leu Lys Glu Ala Ile Pro Arg His Ala Lys
245 250 255Glu Val Thr Asp Lys Met Ile Ser Ser Glu Glu Lys Ser Ile Lys Ala
260 265 270Asn Gln Val Lys Leu Thr Glu Ala Lys Gln Asp Ile Asp Lys Met Glu
275 280 285Lys Ile Ile Lys Asp Leu Glu Ser Lys Lys Asn Thr Leu Ser Val Tyr
290 295 300Leu Lys Phe Gly Glu Ser Phe Thr Ala His Tyr Lys Cys Gln Asn Leu305 310 315 320Ile Glu Val Gly Val Lys Thr Asp Lys Gly Ser Trp Thr Phe Asn Phe
325330335 Asn Arg (2) sequence 1091 data: (i) sequence characteristics: length (A): 847bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 94...807 (D) other information: (xi) Description of the sequence: sequence 1091: GCCTTGACGC ATGTTTTTGA AGTTTATCCT AAAGTCAATA TTTTTTTAAA AATCCTTCAC 60AAAGAAGGGG CTTACCACAA GCTTATTTCT CGC ATG TGT TTG GTC AAA GAC AAG 114
Met Cys Leu Val Lys Asp Lys
1 5CTC AAA GAC ATT ATC AGC GTC AAA AGC GCG CTT TCT TTT TCG TTA AAA 162Leu Lys Asp Ile Ile Ser Val Lys Ser Ala Leu Ser Phe Ser Leu Lys
10 15 20GGG GAT TTT GAC TGC CCT TTA GAA GAA AAC TCG CTC TTT AAA GCC CTC 210Gly Asp Phe Asp Cys Pro Leu Glu Glu Asn Ser Leu Phe Lys Ala Leu
25 30 35CAA ATT TTA AAG AAT TTT TTA AAA TCA AAA AAT TTC TCT CAT TCT GTC 258Gln Ile Leu Lys Asn Phe Leu Lys Ser Lys Asn Phe Ser His Ser Val40 45 50 55ATC AAA TCC CTA GAC ACC CTA GCG ATT GAA GTG GAA AAA AAC ATC CCC 306Ile Lys Ser Leu Asp Thr Leu Ala Ile Glu Val Glu Lys Asn Ile Pro
60 65 70ACT CAA GCC GGA TTA GGC GGT GGG AGC ACT GAT GCT GGG GGG CTA TTG 354Thr Gln Ala Gly Leu Gly Gly Gly Ser Thr Asp Ala Gly Gly Leu Leu
75 80 85TAT CAT TTA AAT CAG ATT TTT GAC TGG CGT TTG AGT TTA GAA GAG CTT 402Tyr His Leu Asn Gln Ile Phe Asp Trp Arg Leu Ser Leu Glu Glu Leu
90 95 100TAT AGC ATG GGA TCT TTA GTG GGC GCG GAC ACC AAT TTT TTC ATC TCG 450Tyr Ser Met Gly Ser Leu Val Gly Ala Asp Thr Asn Phe Phe Ile Ser
105 110 115CAA TAC AAA AGC ACT AAC GCC ACT TCT TAT GGC GAA GTC ATT GAA AAT 498Gln Tyr Lys Ser Thr Asn Ala Thr Ser Tyr Gly Glu Val Ile Glu Asn120 125 130 135TTT GAA GAA GAG CCT TTA GAA AAT CGC CTA GAA ATC TAT GCA CCA AAT 546Phe Glu Glu Glu Pro Leu Glu Asn Arg Leu Glu Ile Tyr Ala Pro Asn
140 145 150CAT GTT TTT TGC AGC ACC AAA GCC GTT TAT CAA GCT TAT AAG CCT GAA 594His Val Phe Cys Ser Thr Lys Ala Val Tyr Gln Ala Tyr Lys Pro Glu
155 160 165ACT TGT TTT TCT CAA GCT AAA GAA TGG CTT AAA AAG CCG AGT TTG GAA 642Thr Cys Phe Ser Gln Ala Lys Glu Trp Leu Lys Lys Pro Ser Leu Glu
170 175 180TGC CTA AAA ACT TAT GAT AGA AAC GGA TTA AAC GAC CTT TTA AAG CCG 690Cys Leu Lys Thr Tyr Asp Arg Asn Gly Leu Asn Asp Leu Leu Lys Pro
185190 195GCT TTA CTC ACT AAC CAA GCC TTA AAA GAT ATA GAA AGC GAA CTA GGC 738Ala Leu Leu Thr Asn Gln Ala Leu Lys Asp Ile Glu Ser Glu Leu Gly200 205 210 215AAG GAG TGG TTT TTT AGC GGG AGC GGG AGC GCG TTT TTT AGG CTA AAG 786Lys Glu Trp Phe Phe Ser Gly Ser Gly Ser Ala Phe Phe Arg Leu Lys
220 225 230CCT ATG CAA AAA GGG GGC GAA TGAAACTCAT TGCCAGCAAC AAAAAAGCCT ATTT 841Pro Met Gln Lys Gly Gly Glu
235 TGCTA 847 (2) sequence 1092 data: (i) sequence characteristics: length (A): 238 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: a sequence 1092: met Cys Leu Val Lys Asp Lys Leu Lys Asp Ile Ile Ser Val Lys Ser 151015 Ala Leu Ser Phe Ser Leu Lys Gly Asp Phe Asp Cys Pro Leu Glu Glu
20 25 30Asn Ser Leu Phe Lys Ala Leu Gln Ile Leu Lys Asn Phe Leu Lys Ser
35 40 45Lys Asn Phe Ser His Ser Val Ile Lys Ser Leu Asp Thr Leu Ala Ile
50 55 60Glu Val Glu Lys Asn Ile Pro Thr Gln Ala Gly Leu Gly Gly Gly Ser65 70 75 80Thr Asp Ala Gly Gly Leu Leu Tyr His Leu Asn Gln Ile Phe Asp Trp
85 90 95Arg Leu Ser Leu Glu Glu Leu Tyr Ser Met Gly Ser Leu Val Gly Ala
100 105 110Asp Thr Asn Phe Phe Ile Ser Gln Tyr Lys Ser Thr Asn Ala Thr Ser
115 120 125Tyr Gly Glu Val Ile Glu Asn Phe Glu Glu Glu Pro Leu Glu Asn Arg
130135 140Leu Glu Ile Tyr Ala Pro Asn His Val Phe Cys Ser Thr Lys Ala Val145 150 155 160Tyr Gln Ala Tyr Lys Pro Glu Thr Cys Phe Ser Gln Ala Lys Glu Trp
165 170 175Leu Lys Lys Pro Ser Leu Glu Cys Leu Lys Thr Tyr Asp Arg Asn Gly
180 185 190Leu Asn Asp Leu Leu Lys Pro Ala Leu Leu Thr Asn Gln Ala Leu Lys
195 200 205Asp Ile Glu Ser Glu Leu Gly Lys Glu Trp Phe Phe Ser Gly Ser Gly
210215220 Ser Ala Phe Phe Arg Leu Lys Pro Met Gln Lys Gly Gly Glu 225230235 (2) sequence 1093 data: (i) sequence characteristics: length (A): 1092bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1047 (D) other information: (xi) Description of the sequence: sequence 1093: TGAAACTATC CATTTAAAGG TGTGAAA ATG GCA AAT TTA GAA AAT TTA GAC TGG 54
Met Ala Asn Leu Glu Asn Leu Asp Trp
1 5AAA AAT TTA GGC TTT AGC TAC ATT AAA ACG GAT TTT CGC TTC ATC GCC 102Lys Asn Leu Gly Phe Ser Tyr Ile Lys Thr Asp Phe Arg Phe Ile Ala10 15 20 25ACT TAT AAA AAC GGC TCT TGG TCG CAA GGC GGA TTG GTG AGC GAA AAC 150Thr Tyr Lys Asn Gly Ser Trp Ser Gln Gly Gly Leu Val Ser Glu Asn
30 35 40ATG TTA CAA CTC AGC GAA GGC TCG CCG GTC TTG CAC TAC GGG CAG GCT 198Met Leu Gln Leu Ser Glu Gly Ser Pro Val Leu His Tyr Gly Gln Ala
45 5055TGT TTT GAA GGC TTG AAG GCT TAC CGC TCT CAA AAG GGG AAA GCT TTA 246Cys Phe Glu Gly Leu Lys Ala Tyr Arg Ser Gln Lys Gly Lys Ala Leu
60 65 70CTC TTT CGC CCT TTA GAA AAC GCC AAA CGC TTG CAA ACT TCA TGC GAA 294Leu Phe Arg Pro Leu Glu Asn Ala Lys Arg Leu Gln Thr Ser Cys Glu
75 80 85AGA CTG CTC ATG CCC AAA GTG AGC GAA GAG CTG TTT TTA AGG GCA TGC 342Arg Leu Leu Met Pro Lys Val Ser Glu Glu Leu Phe Leu Arg Ala Cys90 95 100 105GCT GAA GTG GTG AAA GCG AAT CAA AAA TGG CTC GCT CCT TAT AAA AGC 390Ala Glu Val Val Lys Ala Asn Gln Lys Trp Leu Ala Pro Tyr Lys Ser
110 115 120GGG GCG AGT TTG TAT TTG CGC CCT TTT GTC ATA GGC GTA GGG GAT AAT 438Gly Ala Ser Leu Tyr Leu Arg Pro Phe Val Ile Gly Val Gly Asp Asn
125 130 135TTG GGG GTG AAG CCG GCT AAT GAA TAC CTT TTT ATC GTG TTT TGT GCG 486Leu Gly Val Lys Pro Ala Asn Glu Tyr Leu Phe Ile Val Phe Cys Ala
140 145 150CCT GTG GGG GCG TAT TTT AAG GGG GGT ATA GAA AAA GGG GGG GCT AGG 534Pro Val Gly Ala Tyr Phe Lys Gly Gly Ile Glu Lys Gly Gly Ala Arg
155 160 165TTT ATC ACT ACG ATT TTT GAT AGG GCC GCG CCT AAA GGC ACC GGT GGG 582Phe Ile Thr Thr Ile Phe Asp Arg Ala Ala Pro Lys Gly Thr Gly Gly170 175 180 185GTG AAA GTG GGA GGG AAT TAC GCT GCA AGC CTG TTA GCC CAT AAA ATG 630Val Lys Val Gly Gly Asn Tyr Ala Ala Ser Leu Leu Ala His Lys Met
190 195 200GCC ACA GAG CAA GGC TAT GAT GAT TGC ATT TAT TTA GAC CCT ACT ACG 678Ala Thr Glu Gln Gly Tyr AspAsp Cys Ile Tyr Leu Asp Pro Thr Thr
205 210 215CAC ACT AAA ATT GAA GAA GTG GGG GCG GCG AAT TTT TTT GGC ATC ACG 726His Thr Lys Ile Glu Glu Val Gly Ala Ala Asn Phe Phe Gly Ile Thr
220 225 230CAT GAT GAT GCC TTT ATC ACC CCG CAT TCG CCA AGC ATT CTG CCA AGC 774His Asp Asp Ala Phe Ile Thr Pro His Ser Pro Ser Ile Leu Pro Ser
235 240 245ATT ACC AAA AAA AGC TTG ATG GTT TTG GCT AAA GAA TAT TTG AAC CTC 822Ile Thr Lys Lys Ser Leu Met Val Leu Ala Lys Glu Tyr Leu Asn Leu250 255 260 265AAA GTA GAA GAG AGG GAA ATC CTA ATG GAT GAG TTG GAT GCG TTT AAA 870Lys Val Glu Glu Arg Glu Ile Leu Met Asp Glu Leu Asp Ala Phe Lys
270 275 280GAA GCT GGA GCG TGC GGG ACA GCT GCG ATC ATT ACG CCC ATT AAA GAA 918Glu Ala Gly Ala Cys Gly Thr Ala Ala Ile Ile Thr Pro Ile Lys Glu
285 290 295ATC GTG CAC AAC AAC AAG TCT TAT TTT TTT GAA GCG CCG GGC CAT ATT 966Ile Val His Asn Asn Lys Ser Tyr Phe Phe Glu Ala Pro Gly His Ile
300 305 310ACT AAA CGA CTC TAT GAT TTG CTT TTA TCC ATC CAA CAA GGC GAA CAA 1014Thr Lys Arg Leu Tyr Asp Leu Leu Leu Ser Ile Gln Gln Gly Glu Gln
315320325 GAA GCC CCC AAA GAT TGG ATT TTT GAA GTT GGC TAAAAGGTTA AAATTTATAG 1067Glu Ala Pro Lys Asp Trp Ile Phe Glu Val Gly 330335340 CTGTATGCCG CATAAAATAA GGGCG 1092 (2) sequence 1094 data: (i) sequence characteristics: length (A): 340 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1094: met Ala Asn LeuGlu Asn Leu Asp Trp Lys Asn Leu Gly Phe Ser Tyr 151015 Ile Lys Thr Asp Phe Arg Phe Ile Ala Thr Tyr Lys Asn Gly Ser Trp
20 25 30Ser Gln Gly Gly Leu Val Ser Glu Asn Met Leu Gln Leu Ser Glu Gly
35 40 45Ser Pro Val Leu His Tyr Gly Gln Ala Cys Phe Glu Gly Leu Lys Ala
50 55 60Tyr Arg Ser Gln Lys Gly Lys Ala Leu Leu Phe Arg Pro Leu Glu Asn65 70 75 80Ala Lys Arg Leu Gln Thr Ser Cys Glu Arg Leu Leu Met Pro Lys Val
85 90 95Ser Glu Glu Leu Phe Leu Arg Ala Cys Ala Glu Val Val Lys Ala Asn
100 105 110Gln Lys Trp Leu Ala Pro Tyr Lys Ser Gly Ala Ser Leu Tyr Leu Arg
115 120 125Pro Phe Val Ile Gly Val Gly Asp Asn Leu Gly Val Lys Pro Ala Asn
130 135 140Glu Tyr Leu Phe Ile Val Phe Cys Ala Pro Val Gly Ala Tyr Phe Lys145 150 155 160Gly Gly Ile Glu Lys Gly Gly Ala Arg Phe Ile Thr Thr Ile Phe Asp
165 170 175Arg Ala Ala Pro Lys Gly Thr Gly Gly Val Lys Val Gly Gly Asn Tyr
180 185 190Ala Ala Ser Leu Leu Ala His Lys Met Ala Thr Glu Gln Gly Tyr Asp
195 200 205Asp Cys Ile Tyr Leu Asp Pro Thr Thr His Thr Lys Ile Glu Glu Val
210 215 220Gly Ala Ala Asn Phe Phe Gly Ile Thr His Asp Asp Ala Phe Ile Thr225 230235 240Pro His Ser Pro Ser Ile Leu Pro Ser Ile Thr Lys Lys Ser Leu Met
245 250 255Val Leu Ala Lys Glu Tyr Leu Asn Leu Lys Val Glu Glu Arg Glu Ile
260 265 270Leu Met Asp Glu Leu Asp Ala Phe Lys Glu Ala Gly Ala Cys Gly Thr
275 280 285Ala Ala Ile Ile Thr Pro Ile Lys Glu Ile Val His Asn Asn Lys Ser
290 295 300Tyr Phe Phe Glu Ala Pro Gly His Ile Thr Lys Arg Leu Tyr Asp Leu305 310 315 320Leu Leu Ser Ile Gln Gln Gly Glu Gln Glu Ala Pro Lys Asp Trp Ile
325 330 335Phe Glu Val Gly
340 (2) sequence 1095 data: (i) sequence characteristics: length (A): 2111bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 3l.. 2067 (D) other information: (xi) Description of the sequence: sequence 1095: GTTATAATTT TATTTTTTAA AAGGATACCC ATG AAT AAA GTT CAA TCT ATT GAT 54
Met Asn Lys Val Gln Ser Ile Asp
1 5CCT TTA ATC GCT GAT AAG TTC AAC AAC GAG TTA AGA AGT TAT AAC CTA 102Pro Leu Ile Ala Asp Lys Phe Asn Asn Glu Leu Arg Ser Tyr Asn Leu
10 15 20GAA TAC AAA CTA GAG CAA GAA AGC CTG AAT AAA GAA ATT GAT GAA GCT 150Glu Tyr Lys Leu Glu Gln Glu Ser Leu Asn Lys Glu Ile Asp Glu Ala25 30 35 40TTA AAA AAT TAC GCT TCT AAA AAT GGG GGT TTA GGG GGT AAC CGC CCT 198Leu Lys Asn Tyr Ala Ser Lys Asn Gly Gly Leu Gly Gly Asn Arg Pro
45 50 55GAT GTG AAA CTT TTA TTA AAC ACA CAA GAC CCC AAC AGA AGA GTC CCT 246Asp Val Lys Leu Leu Leu Asn Thr Gln Asp Pro Asn Arg Arg Val Pro
60 65 70ATT TTA ATA GAA TAC AAA GGG CTA AAA GAT AAG CTC ATT AAA TTA GAC 294Ile Leu Ile Glu Tyr Lys Gly Leu Lys Asp Lys Leu Ile Lys Leu Asp
75 80 85AAA AAC AAA CTG GTA GAA AAC TTT AAA AAC CAT GAG CCT CAT TAT AAA 342Lys Asn Lys Leu Val Glu Asn Phe Lys Asn His Glu Pro His Tyr Lys
90 95 100AAC ATT AGA GAA TAC GCC CTA AAT GGG GCT TTG CAT TAC GCT AAT GCG 390Asn Ile Arg Glu Tyr Ala Leu Asn Gly Ala Leu His Tyr Ala Asn Ala105 110 115 120ATT TTA CAC CAC ACG AGC TAC ACT GAA TGC ATC GCC ATA GGC ATT ACA 438Ile Leu His His Thr Ser Tyr Thr Glu Cys Ile Ala Ile Gly Ile Thr
125 130 135GGC TAT AAA GAC AAT AAG GGC GGC ATA TGC TCT CAA ATC GCT GTC TAT 486Gly Tyr Lys Asp Asn Lys Gly Gly Ile Cys Ser Gln Ile Ala Val Tyr
140 145 150TAT GTG AAT AAA AGC AAT CTA GGC ATG GGG ATA GAT GTT TCA AAA GGC 534Tyr Val Asn Lys Ser Asn Leu Gly Met Gly Ile Asp Val Ser Lys Gly
155 160 165GAG CAA GGT TAT AGC GAT CTC TCC TTT TTA AGC CGT AAG CAT TTT AAC 582Glu Gln Gly Tyr Ser Asp Leu Ser Phe Leu Ser Arg Lys His Phe Asn
170 175 180GAC TTT ATT AAA CGA GTA GAC ACC CTT TCT TTA AGC GAT GAA GAT TTA 630Asp Phe Ile Lys Arg Val Asp Thr Leu Ser Leu Ser Asp Glu Asp Leu185 190 195 200GAG CGC ATT AGA GAA AAG AAA AAC CAA GAA ATA GAA GAC TGC TTA ATG 678Glu Arg Ile Arg Glu Lys Lys Asn Gln Glu Ile Glu Asp Cys Leu Met
205 210 215CGG CTC AAC AAC AAT ATT TAC AAC AAA GAA AAG AAT TTT TTA AGC GAA 726Arg Leu Asn Asn Asn Ile Tyr Asn Lys Glu Lys Asn Phe Leu Ser Glu
220 225 230CAC AAT CGG GTA TAT TTA GTG ATT GCG AGC ATT ATC GCT AAT TTA GGC 774His Asn Arg Val Tyr Leu Val Ile Ala Ser Ile Ile Ala Asn Leu Gly
235 240 245ATC CCT AAT TTG GTA ACC CCC CTA AAC AAA GAA GAT CTA AAA TCC AGC 822Ile Pro Asn Leu Val Thr Pro Leu Asn Lys Glu Asp Leu Lys Ser Ser
250 255 260GAT GAG GTC CAT CAA AGA GAT GGC GAC ATC ATG CTC AGA AAA ATC CAA 870Asp Glu Val His Gln Arg Asp Gly Asp Ile Met Leu Arg Lys Ile Gln265 270 275 280TCC TTT TTA GAG AAT AAG GAT TTG TCT CCA GAG AAA AGG CAA AGC ATT 918Ser Phe Leu Glu Asn Lys Asp Leu Ser Pro Glu Lys Arg Gln Ser Ile
285 290 295ATT TCT TCA TTA GAG ACT TTA TTA AGA AAC GAA AAC AAC AAC AAA GCC 966Ile Ser Ser Leu Glu Thr Leu Leu Arg Asn Glu Asn Asn Asn Lys Ala
300 305 310ACT AAT GGC GAA AGC TGT TTG AAG CGT TGT TTT AGT GAG ATT GTG GAT 1014Thr Asn Gly Glu Ser Cys Leu Lys Arg Cys Phe Ser Glu Ile Val Asp
315 320 325AGT TTG GGC ATT TAT TAT AAA ATC GGT CTT AGC ACG GAT TTT ACC GGT 1062Ser Leu Gly Ile Tyr Tyr Lys Ile Gly Leu Ser Thr Asp Phe Thr Gly
330 335340AAA TTG TTC AAT GAA ATG TAT CGC TGG CTG GGT TTC ACG AAA GAC CAA 1110Lys Leu Phe Asn Glu Met Tyr Arg Trp Leu Gly Phe Thr Lys Asp Gln345 350 355 360TTA AAC GAT GTG GTG CTC ACA CCC CCT TAT GTC GCC ACG CTT TTA GCT 1158Leu Asn Asp Val Val Leu Thr Pro Pro Tyr Val Ala Thr Leu Leu Ala
365 370 375AGA CTT TCT AAA GTC AAT AAG GAT AGT TTC GTG TGG GAT TTT GCC ACC 1206Arg Leu Ser Lys Val Asn Lys Asp Ser Phe Val Trp Asp Phe Ala Thr
380 385 390GGA AGC GCT GGG CTA TTA GTC GCA AGC ATG AAT TTG ATG ATA GAA GAC 1254Gly Ser Ala Gly Leu Leu Val Ala Ser Met Asn Leu Met Ile Glu Asp
395 400 405GCT AAA AAG CGT ATC ACT AGT CCA GAG GAA TTA GAG CAA AAA ATC GCC 1302Ala Lys Lys Arg Ile Thr Ser Pro Glu Glu Leu Glu Gln Lys Ile Ala
410 415 420CAC ATT AAA GCC AAG CAA CTT TTA GGG ATA GAA ATC TTA TCG GAT ATC 1350His Ile Lys Ala Lys Gln Leu Leu Gly Ile Glu Ile Leu Ser Asp Ile425 430 435 440CAT ACT TTA GCG GTG TTA AAC ATG ATT TTA ATG GGC GAT GGG AGC AGT 1398His Thr Leu Ala Val Leu Asn Met Ile Leu Met Gly Asp Gly Ser Ser
445 450 455CAA ATC TTA AAC CAA GAC GGC TTG AGC GGT TTT GAT GGC AAA GTC AAT 1446Gln Ile Leu Asn Gln Asp Gly Leu Ser Gly Phe Asp Gly Lys Val Asn
460 465 470AAC GAA GCG TTT AAG GCT AAT GCC TTT GTT TTA AAC CCG CCT TAT TCC 1494Asn Glu Ala Phe Lys Ala Asn Ala Phe Val Leu Asn Pro Pro Tyr Ser
475 480 485GCT AGC GGT AAT GGC ATG GTG TTT GTG GAG CAG GCT TTA GAAAAA ATG 1542Ala Ser Gly Asn Gly Met Val Phe Val Glu Gln Ala Leu Glu Lys Met
490 495 500CAA AGC GGT TAT GCG AGC GTG ATC ATC CAA TCA AGC GCC GGC AGT GGT 1590Gln Ser Gly Tyr Ala Ser Val Ile Ile Gln Ser Ser Ala Gly Ser Gly505 510 515 520AAA GCC AAA GAA TAC AAT GTA AGG ATT TTG GAA AAA CAC ACG CTT TTA 1638Lys Ala Lys Glu Tyr Asn Val Arg Ile Leu Glu Lys His Thr Leu Leu
525 530 535GCG AGC ATT AAA ATG CCT TTA GAT TTA TTC ATC GGT AAA AGC AGC GTT 1686Ala Ser Ile Lys Met Pro Leu Asp Leu Phe Ile Gly Lys Ser Ser Val
540 545 550CAA ACC CAT ATC TAT GTT TTT AGG GTC AAT GAA AAG CAT GAC GCT AAG 1734Gln Thr His Ile Tyr Val Phe Arg Val Asn Glu Lys His Asp Ala Lys
555 560 565CAA AGG GTG AAA TTT ATT AAT TTC AGT AAC GAC GGC TAC GCT AGA GCG 1782Gln Arg Val Lys Phe Ile Asn Phe Ser Asn Asp Gly Tyr Ala Arg Ala
570 575 580AAT CGC AAA AAA GCC AAA GCC AGC CAC AAT TTA AAA GAC ACG CAT AAC 1830Asn Arg Lys Lys Ala Lys Ala Ser His Asn Leu Lys Asp Thr His Asn585 590 595 600GCC AAA GAG CGC TAC AAC GAA GTC GTG GAT TTA GTC CAT ATT GGC CAA 1878Ala Lys Glu Arg Tyr Asn Glu Val Val Asp Leu Val His Ile Gly Gln
605 610 615TCA TGT TTG AAA TTT CTA AGC GAA GAT GAC TAT TAT GAA AAC ACC ATA 1926Ser Cys Leu Lys Phe Leu Ser Glu Asp Asp Tyr Tyr Glu Asn Thr Ile
620 625 630GAT CCC AAA AAC GGG AGC GAT TGG AAC CAA AAC AAA CCC ACT GAC ACC 1974Asp Pro Lys Asn Gly Ser Asp Trp Asn Gln Asn Lys Pro Thr Asp Thr
635 640 645AAA CCC GAA TTA GAG GAT TTT AAA AGA ACG ATA GCC GAT TAC CTT TCT 2022Lys Pro Glu Leu Glu Asp Phe Lys Arg Thr Ile Ala Asp Tyr Leu Ser
650655660 TAT GAA GTA AGC TTG ATT TTA AAA AAC CAA ATG CCC CCA AAG CGA TAGGC 2072Tyr Glu Val Ser Leu Ile Leu Lys Asn Gln Met Pro Pro Lys Arg 665670675 CCCCCTTAATA GCCAACTCAA CGCTATTAAG TGGGGCGAG 2111 (2) sequence 1096 data: (i) sequence characteristics: length (A): 679 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1096: met Asn Lys Val Gln Ser Ile Asp Pro Leu Ile Ala Asp Lys Phe Asn 151015 Asn Glu Leu Arg Ser Tyr Asn Leu Glu Tyr Lys Leu Glu Gln Glu Ser
20 25 30Leu Asn Lys Glu Ile Asp Glu Ala Leu Lys Asn Tyr Ala Ser Lys Asn
35 40 45Gly Gly Leu Gly Gly Asn Arg Pro Asp Val Lys Leu Leu Leu Asn Thr
50 55 60Gln Asp Pro Asn Arg Arg Val Pro Ile Leu Ile Glu Tyr Lys Gly Leu65 70 75 80Lys Asp Lys Leu Ile Lys Leu Asp Lys Asn Lys Leu Val Glu Asn Phe
85 90 95Lys Asn His Glu Pro His Tyr Lys Asn Ile Arg Glu Tyr Ala Leu Asn
100 105 110
Gly Ala Leu His Tyr Ala Asn Ala Ile Leu His His Thr Ser Tyr Thr
115 120 125Glu Cys Ile Ala Ile Gly Ile Thr Gly Tyr Lys Asp Asn Lys Gly Gly
130 135 140Ile Cys Ser Gln Ile Ala Val Tyr Tyr Val Asn Lys Ser Asn Leu Gly145150 155 160Met Gly Ile Asp Val Ser Lys Gly Glu Gln Gly Tyr Ser Asp Leu Ser
165 170 175Phe Leu Ser Arg Lys His Phe Asn Asp Phe Ile Lys Arg Val Asp Thr
180 185 190Leu Ser Leu Ser Asp Glu Asp Leu Glu Arg Ile Arg Glu Lys Lys Asn
195 200 205Gln Glu Ile Glu Asp Cys Leu Met Arg Leu Asn Asn Asn Ile Tyr Asn
210 215 220Lys Glu Lys Asn Phe Leu Ser Glu His Asn Arg Val Tyr Leu Val Ile225 230 235 240Ala Ser Ile Ile Ala Asn Leu Gly Ile Pro Asn Leu Val Thr Pro Leu
245 250 255Asn Lys Glu Asp Leu Lys Ser Ser Asp Glu Val His Gln Arg Asp Gly
260 265 270Asp Ile Met Leu Arg Lys Ile Gln Ser Phe Leu Glu Asn Lys Asp Leu
275 280 285Ser Pro Glu Lys Arg Gln Ser Ile Ile Ser Ser Leu Glu Thr Leu Leu
290 295 300Arg Asn Glu Asn Asn Asn Lys Ala Thr Asn Gly Glu Ser Cys Leu Lys305 310 315 320Arg Cys Phe Ser Glu Ile Val Asp Ser Leu Gly Ile Tyr Tyr Lys Ile
325 330 335Gly Leu Ser Thr Asp Phe Thr Gly Lys Leu Phe Asn Glu Met Tyr Arg
340 345 350Trp Leu Gly Phe Thr Lys Asp Gln Leu Asn Asp Val Val Leu Thr Pro
355 360 365Pro Tyr Val Ala Thr Leu Leu Ala Arg Leu Ser Lys Val Asn Lys Asp
370 375 380Ser Phe Val Trp Asp Phe Ala Thr Gly Ser Ala Gly Leu Leu Val Ala385 390 395 400Ser Met Asn Leu Met Ile Glu Asp Ala Lys Lys Arg Ile Thr Ser Pro
405 410 415Glu Glu Leu Glu Gln Lys Ile Ala His Ile Lys Ala Lys Gln Leu Leu
420 425 430Gly Ile Glu Ile Leu Ser Asp Ile His Thr Leu Ala Val Leu Asn Met
435 440 445Ile Leu Met Gly Asp Gly Ser Ser Gln Ile Leu Asn Gln Asp Gly Leu
450 455 460Ser Gly Phe Asp Gly Lys Val Asn Asn Glu Ala Phe Lys Ala Asn Ala465 470 475 480Phe Val Leu Asn Pro Pro Tyr Ser Ala Ser Gly Asn Gly Met Val Phe
485 490 495Val Glu Gln Ala Leu Glu Lys Met Gln Ser Gly Tyr Ala Ser Val Ile
500 505 510Ile Gln Ser Ser Ala Gly Ser Gly Lys Ala Lys Glu Tyr Asn Val Arg
515 520 525Ile Leu Glu Lys His Thr Leu Leu Ala Ser Ile Lys Met Pro Leu Asp
530 535 540Leu Phe Ile Gly Lys Ser Ser Val Gln Thr His Ile Tyr Val Phe Arg545 550 555 560Val Asn Glu Lys His Asp Ala Lys Gln Arg Val Lys Phe Ile Asn Phe
565 570 575Ser Asn Asp Gly Tyr Ala Arg Ala Asn Arg Lys Lys Ala Lys Ala Ser
580 585 590His Asn Leu Lys Asp Thr His Asn Ala Lys Glu Arg Tyr Asn Glu Val
595 600 605Val Asp Leu Val His Ile Gly Gln Ser Cys Leu Lys Phe Leu Ser Glu
610 615 620Asp Asp Tyr Tyr Glu Asn Thr Ile Asp Pro Lys Asn Gly Ser Asp Trp625 630 635 640Asn Gln Asn Lys Pro Thr Asp Thr Lys Pro Glu Leu Glu Asp Phe Lys
645 650 655Arg Thr Ile Ala Asp Tyr Leu Ser Tyr Glu Val Ser Leu Ile Leu Lys
660 665 670Asn Gln Met Pro Pro Lys Arg
675
(2) Sequence 1097 data:
(i) sequence characteristics:
(A) length: 644 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...597
(D) Other information:
(xi) Description of the sequence: sequence 1097: ATCCTTTGAT TTCAAAGGCT TAAA ATG TAT GTG GTG TTA GAA GGC GTT GAT 51
Met Tyr Val Val Leu Glu Gly Val Asp
1 5GGC GCG GGC AAA AGC ACT CAA GTA GAA TTA TTA AAA GAC CGG TTT AAA 99Gly Ala Gly Lys Ser Thr Gln Val Glu Leu Leu Lys Asp Arg Phe Lys10 15 20 25AAC GCC CTT TTT ACC AAA GAG CCA GGG GGG ACG AGA ATG GGC GAG AGT 147Asn Ala Leu Phe Thr Lys Glu Pro Gly Gly Thr Arg Met Gly Glu Ser
30 35 40TTA AGG CGT ATC GCT TTG AAT GAA AAC ATT AGC GAA TTG GCT AGA GCG 195Leu Arg Arg Ile Ala Leu Asn Glu Asn Ile Ser Glu Leu Ala Arg Ala
45 50 55TTT TTA TTC TTA AGC GAT AGG GCT GAG CAT ACA GAA AGC GTG ATA AAA 243Phe Leu Phe Leu Ser Asp Arg Ala Glu His Thr Glu Ser Val Ile Lys
60 65 70CCG GCA TTG AAA GAA AAA AAG CTC ATC ATT AGC GAC AGG AGC TTG ATC 291Pro Ala Leu Lys Glu Lys Lys Leu Ile Ile Ser Asp Arg Ser Leu Ile
75 80 85TCT GGC ATG GCT TAT AGC CAA TTT TCA AGC TTA GAA TTA AAC CTG CTT 339Ser Gly Met Ala Tyr Ser Gln Phe Ser Ser Leu Glu Leu Asn Leu Leu90 95 100 105GCC ACC CAA AGC GTC TTG CCT GCA AAA ATC ATT CTT TTA CTC ATA GAC 387Ala Thr Gln Ser Val Leu Pro Ala Lys Ile Ile Leu Leu Leu Ile Asp
110 115 120AAA GAG GGC TTA AAA CAG CGC TTA AGC CTT AAA AGT TTA GAT AAA ATA 435Lys Glu Gly Leu Lys Gln Arg Leu Ser Leu Lys Ser Leu Asp Lys Ile
125 130 135GAA AAC CAA GGC ATA GAA AAA TTA CTT CAT ATC CAG CAA AAG CTC AAA 483Glu Asn Gln Gly Ile Glu Lys Leu Leu His Ile Gln Gln Lys Leu Lys
140 145 150ACC CAC GCT TAT GCG TTA CAA GAA AAA TTT GGG TGC GAA GTT TTG GAA 531Thr His Ala Tyr Ala Leu Gln Glu Lys Phe Gly Cys Glu Val Leu Glu
155 160 165TTA GAC GCT AAA GAA AGC GTT AAA AAC TTG CAC GAA AAA ATC GCC GCT 579Leu Asp Ala Lys Glu Ser Val Lys Asn Leu His Glu Lys Ile Ala Ala170 175 180 185TTT ATA AAA TGC GCT GTT TAACCTGTTT GAAGCTTTCT TTTAAGCCTC TTTGCCCA 635Phe Ile Lys Cys Ala Val
190AATTGCTTG 644
(2) Sequence 1098 data:
(i) sequence characteristics:
(A) length: 191 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1098: met Tyr Val Val Leu Glu Gly Val Asp Gly Ala Gly Lys Ser Thr Gln 151015 Val Glu Leu Leu Lys Asp Arg Phe Lys Asn Ala Leu Phe Thr Lys Glu
20 25 30Pro Gly Gly Thr Arg Met Gly Glu Ser Leu Arg Arg Ile Ala Leu Asn
35 40 45Glu Asn Ile Ser Glu Leu Ala Arg Ala Phe Leu Phe Leu Ser Asp Arg
50 55 60Ala Glu His Thr Glu Ser Val Ile Lys Pro Ala Leu Lys Glu Lys Lys65 70 75 80Leu Ile Ile Ser Asp Arg Ser Leu Ile Ser Gly Met Ala Tyr Ser Gln
85 90 95Phe Ser Ser Leu Glu Leu Ash Leu Leu Ala Thr Gln Ser Val Leu Pro
100 105 110Ala Lys Ile Ile Leu Leu Leu Ile Asp Lys Glu Gly Leu Lys Gln Arg
115 120 125Leu Ser Leu Lys Ser Leu Asp Lys Ile Glu Asn Gln Gly Ile Glu Lys
130 135 140Leu Leu His Ile Gln Gln Lys Leu Lys Thr His Ala Tyr Ala Leu Gln145 150 155 160Glu Lys Phe Gly Cys Glu Val Leu Glu Leu Asp Ala Lys Glu Ser Val
165 170 175Lys Asn Leu His Glu Lys Ile Ala Ala Phe Ile Lys Cys Ala Val
180 185 190
(2) Sequence 1099 data:
(i) sequence characteristics:
(A) length: 620 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 23...583
(D) Other information:
(xi) Description of the sequence: sequence 1099: GCAAATCTTA TAAAGGACAT TC ATG AAA TTG GTT TTA GGC ATC AGT GGA GCG 52
Met Lys Leu Val Leu Gly Ile Ser Gly Ala
1 5 10AGC GGG ATA CCC CTA GCC TTG CGG TTT TTA GAA AAA TTA CCC AAA GAA 100Ser Gly Tle Pro Leu Ala Leu Arg Phe Leu Glu Lys Leu Pro Lys Glu
15 20 25ATT GAA GTT TTT GTC GTG GCG TCT AAA AAC GCG CAT GTC GTG GCG TTA 148Tle Glu Val Phe Val Val Ala Ser Lys Asn Ala His Val Val Ala Leu
30 35 40GAA GAA TCT AAT ATT AAC CTT AAA AAC GCC ATG AAA GAT TTA CGG CCT 196Glu Glu Ser Asn Ile Asn Leu Lys Asn Ala Met Lys Asp Leu Arg Pro
45 50 55AGT GGT ACT TTT TTC AAC GAG CAA GAC ATC CAT GCG AGC ATC GCT TCA 244Ser Gly Thr Phe Phe Asn Glu Gln Asp Ile His Ala Ser Ile Ala Ser
60 65 70GGG AGT TAT GGT ATC CAT AAA ATG GCG ATC ATT CCA GCG AGC ATG GAC 292Gly Ser Tyr Gly Ile His Lys Met Ala Ile Ile Pro Ala Ser Met Asp75 80 85 90ATG GTG GCT AAA ATC GCG CAT GGC TTT GGG GGG GAT TTG ATT TCT AGG 340Met Val Ala Lys Ile Ala His Gly Phe Gly Gly Asp Leu Ile Ser Arg
95 100 105AGT GCG TCT GTG ATG CTT AAA GAA AAG CGC CCC TTA CTC ATT GCC CCT 388Ser Ala Ser Val Met Leu Lys Glu Lys Arg Pro Leu Leu Ile Ala Pro
110 115 120AGA GAA ATG CCT TTA AGC GCT ATC ATG TTA GAA AAT TTG CTC AAA CTC 436Arg Glu Met Pro Leu Ser Ala Ile Met Leu Glu Asn Leu Leu Lys Leu
125 130 135TCC CAT TCT AAT GCA ATC ATT GCG CCG CCG ATG ATG ACT TAT TAC ACC 484Ser His Ser Asn Ala Ile Ile Ala Pro Pro Met Met Thr Tyr Tyr Thr
140 145 150CAG AGC AAG ACT TTA GAA GCG ATG CAA GAT TTT TTA GTG GGG AAG TGG 532Gln Ser Lys Thr Leu Glu Ala Met Gln Asp Phe Leu Val Gly Lys Trp155 160 165 170TTT GAC AGC TTA GGG ATA GAA AAT GAC TTA TAC CCA CGA TGG GGA ATG 580Phe Asp Ser Leu Gly Ile Glu Asn Asp Leu Tyr Pro Arg Trp Gly Met
175 180 185AAC TGATGCAAAA AATCGGCATT TACCCGGGCA CTTTTGA 620Asn
(2) Sequence 1100 data:
(i) sequence characteristics:
(A) length: 187 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1100: met Lys Leu Val Leu Gly Ile Ser Gly Ala Ser Gly Ile Pro Leu Ala 151015 Leu Arg Phe Leu Glu Lys Leu Pro Lys Glu Ile Glu Val Phe Val Val
20 25 30Ala Ser Lys Asn Ala His Val Val Ala Leu Glu Glu Ser Asn Ile Asn
35 40 45Leu Lys Asn Ala Met Lys Asp Leu Arg Pro Ser Gly Thr Phe Phe Asn
50 55 60Glu Gln Asp Ile His Ala Ser Ile Ala Ser Gly Ser Tyr Gly Ile His65 70 75 80Lys Met Ala Ile Ile Pro Ala Ser Met Asp Met Val Ala Lys Ile Ala
85 90 95His Gly Phe Gly Gly Asp Leu Ile Ser Arg Ser Ala Ser Val Met Leu
100 105 110Lys Glu Lys Arg Pro Leu Leu Ile Ala Pro Arg Glu Met Pro Leu Ser
115 120 125Ala Ile Met Leu Clu Asn Leu Leu Lys Leu Ser His Ser Asn Ala Ile
130 135 140Ile Ala Pro Pro Met Met Thr Tyr Tyr Thr Gln Ser Lys Thr Leu Glu145 150 155 160Ala Met Gln Asp Phe Leu Val Gly Lys Trp Phe Asp Ser Leu Gly Ile
165 170 175Glu Asn Asp Leu Tyr Pro Arg Trp Gly Met Asn
180 185
(2) Sequence 1101 data:
(i) sequence characteristics:
(A) length: 341 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 13...309
(D) Other information:
(xi) Description of the sequence: sequence 1101: CTCCCTGAAG CG ATG CTC GCA TGG ATG TCT TGC TCG TTG AAA AAA GTA CCA 51
Met Leu Ala Trp Met Ser Cys Ser Leu Lys Lys Val Pro
1 5 10CTA GGC CGT AAA TCT TTC ATG GCG TTT TTA AGG TTA ATA TTA GAT TCT 99Leu Gly Arg Lys Ser Phe Met Ala Phe Leu Arg Leu Ile Leu Asp Ser
15 20 25TCT AAC GCC ACG ACA TGC GCG TTT TTA GAC GCC ACG ACA AAA ACT TCA 147Ser Asn Ala Thr Thr Cys Ala Phe Leu Asp Ala Thr Thr Lys Thr Ser30 35 40 45ATT TCT TTG GGT AAT TTT TCT AAA AAC CGC AAG GCT AGG GGT ATC CCG 195Ile Ser Leu Gly Asn Phe Ser Lys Asn Arg Lys Ala Arg Gly Ile Pro
50 55 60CTC GCT CCA CTG ATG CCT AAA ACC AAT TTC ATG AAT GTC CTT TAT AAG 243Leu Ala Pro Leu Met Pro Lys Thr Asn Phe Met Asn Val Leu Tyr Lys
65 7075ATT TGC GCT TTA GAG CTG CTC AAC ACT TTT GCT TTG AGT ATT TTA TTG 291Ile Cys Ala Leu Glu Leu Leu Asn Thr Phe Ala Leu Ser Ile Leu Leu
80 85 90CTT TCT AAA TTT TTC GCT TGAATGATTT GATTAAGCGC GCCATTTTCT AG 341Leu Ser Lys Phe Phe Ala
95
(2) Data of sequence 1102:
(i) sequence characteristics:
(A) length: 99 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1102: met Leu Ala Trp Met Ser Cys Ser Leu Lys Lys Val Pro Leu Gly Arg 151015 Lys Ser Phe Met Ala Phe Leu Arg Leu Ile Leu Asp Ser Ser Asn Ala
20 25 30Thr Thr Cys Ala Phe Leu Asp Ala Thr Thr Lys Thr Ser Ile Ser Leu
35 40 45Gly Asn Phe Ser Lys Asn Arg Lys Ala Arg Gly Ile Pro Leu Ala Pro
50 55 60Leu Met Pro Lys Thr Asn Phe Met Asn Val Leu Tyr Lys Ile Cys Ala65 70 75 80Leu Glu Leu Leu Asn Thr Phe Ala Leu Ser Ile Leu Leu Leu Ser Lys
85 90 95Phe Phe Ala
(2) Sequence 1103 data:
(i) sequence characteristics:
(A) length: 858 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 85...822
(D) Other information:
(xi) Description of the sequence: sequence 1103: GGCGCCAACG ATTTTAATGA TCCTCATTGT GATTTTAGTG GTTGTCAAGC CTTTTTAAAG 60ACAAGCCATG AAAAAAGAAA AGTC ATG AAA AAA GAA AAG CAT CTC AAG CAA 111
Met Lys Lys Glu Lys His Leu Lys Gln
1 5GAA AAA ATC ATC AAC ATG TTT GAT GAT ATA GCC AGC TCT TAC GAT CAA 159Glu Lys Ile Ile Asn Met Phe Asp Asp Ile Ala Ser Ser Tyr Asp Gln10 15 20 25GCC AAC CGC TTG ATG AGT TTT GGC TTA GAC GTT AAA TGG CGA GAA AGG 207Ala Asn Arg Leu Met Ser Phe Gly Leu Asp Val Lys Trp Arg Glu Arg
30 35 40GCT TGC GAG CAT GCG TTT TTA TTT TTA GAA AAC AAG AAA GCG TTA AGG 255Ala Cys Glu His Ala Phe Leu Phe Leu Glu Asn Lys Lys Ala Leu Arg
45 50 55CTT GTG GAT GTG GCA TGC GGG ACG GGG GAT ATG CTT GTG GCT TGG CAA 303Leu Val Asp Val Ala Cys Gly Thr Gly Asp Met Leu Val Ala Trp Gln
60 65 70AAA AGC GCT CTC AAT TGC GGT ATA GAG TTT AAG GAA TGT TTG GGG ATT 351Lys Ser Ala Leu Asn Cys Gly Ile Glu Phe Lys Glu Cys Leu Gly Ile
75 80 85GAC CCC TCT AAT AAC ATG CTT GAA TTA GCC ATC AAA AAA TGT GAA GAG 399Asp Pro Ser Asn Asn Met Leu Glu Leu Ala Ile Lys Lys Cys Glu Glu9095 100 105CTT GAA AAC AAA GCT TCT TTC ATC CAA GCT CAA GCC AAA GAT TTA AAA 447Leu Glu Asn Lys Ala Ser Phe Ile Gln Ala Gln Ala Lys Asp Leu Lys
110 115 120GGC GTT GAA AAT AAC AGC GTG GAT ATC CTC TCT ATT GCG TAT GGC TTG 495Gly Val Glu Asn Asn Ser Val Asp Ile Leu Ser Ile Ala Tyr Gly Leu
125 130 135CGT AAT GTC GTG GAA AGA CAA GAG GCC TTA AAA GAG TTT TTT AGG GTG 543Arg Asn Val Val Glu Arg Gln Glu Ala Leu Lys Glu Phe Phe Arg Val
140 145 150TTA AAA CCC AGG GGC GTT TTA GTG ATT TTA GAA TTT TTA AAA AAA GAC 591Leu Lys Pro Arg Gly Val Leu Val Ile Leu Glu Phe Leu Lys Lys Asp
155 160 165AAC CCC ACA TGG CTG GAT AAA ATC TCA GGG TTT TAC ACG AAT AAG GTT 639Asn Pro Thr Trp Leu Asp Lys Ile Ser Gly Phe Tyr Thr Asn Lys Val170 175 180 185TTG CCT TTA GTG GGA GGG GCT ATC AGT AAG AAT TAT GGT GCT TAT TCT 687Leu Pro Leu Val Gly Gly Ala Ile Ser Lys Asn Tyr Gly Ala Tyr Ser
190 195 200TAT TTA CCG CAA TCC ATT GAG GGG TTT TTG AGT TTA GAG GGT TTG AAG 735Tyr Leu Pro Gln Ser Ile Glu Gly Phe Leu Ser Leu Glu Gly Leu Lys
205 210 215CAT GAA TTA AGA AAC GCA GGG TTT GAG ATT TTA AGG ACT GAA GAT TCT 783His Glu Leu Arg Asn Ala Gly Phe Glu Ile Leu Arg Thr Glu Asp Ser
220 225 230ATC GCT CAA ATT TCA ACG ACC ATG CTT GTT AAA AAA AAC TAAAGGAATG TT 834Ile Ala Gln Ile Ser Thr Thr Met Leu Val Lys Lys Asn
235 240 245ATGCAAGATG AATTATTTGA AACC 858
(2) Sequence l104 data:
(i) sequence characteristics:
(A) length: 246 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1104: met Lys Lys Glu Lys His Leu Lys Gln Glu Lys Ile Ile Asn Met Phe 151015 Asp Asp Ile Ala Ser Ser Tyr Asp Gln Ala Asn Arg Leu Met Ser Phe
20 25 30Gly Leu Asp Val Lys Trp Arg Glu Arg Ala Cys Glu His Ala Phe Leu
35 40 45Phe Leu Glu Asn Lys Lys Ala Leu Arg Leu Val Asp Val Ala Cys Gly
50 55 60Thr Gly Asp Met Leu Val Ala Trp Gln Lys Ser Ala Leu Asn Cys Gly65 70 75 80Ile Glu Phe Lys Glu Cys Leu Gly Ile Asp Pro Ser Asn Asn Met Leu
85 90 95Glu Leu Ala Ile Lys Lys Cys Glu Glu Leu Glu Asn Lys Ala Ser Phe
100 105 110Ile Gln Ala Gln Ala Lys Asp Leu Lys Gly Val Glu Asn Asn Ser Val
115 120 125Asp Ile Leu Ser Ile Ala Tyr Gly Leu Arg Asn Val Val Glu Arg Gln
130 135 140Glu Ala Leu Lys Glu Phe Phe Arg Val Leu Lys Pro Arg Gly Val Leu145 150 155 160Val Ile Leu Glu Phe Leu Lys Lys Asp Asn Pro Thr Trp Leu Asp Lys
165 170 175Ile Ser Gly Phe Tyr Thr Asn Lys Val Leu Pro Leu Val Gly Gly Ala
180 185 190Ile Ser Lys Asn Tyr Gly Ala Tyr Ser Tyr Leu Pro Gln Ser Ile Glu
195 200 205Gly Phe Leu Ser Leu Glu Gly Leu Lys His Glu Leu Arg Asn Ala Gly
210 215 220Phe Glu Ile Leu Arg Thr Glu Asp Ser Ile Ala Gln Ile Ser Thr Thr225 230 235 240Met Leu Val Lys Lys Asn
245
(2) Sequence 1105 data:
(i) sequence characteristics:
(A) length: 1443 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 57...1403
(D) Other information:
(xi) Description of the sequence: sequence 1105: AAAATTCTGA GATTTTATAT ATTTTATATT TATCGTTAGG TTTTAGGTTT AAAGTT ATG 59
Met
1GGG AGG AAT CAA GGA GCT TAT TTG GAT CCG TCT GAA TCG ATT TTG ATG 107Gly Arg Asn Gln Gly Ala Tyr Leu Asp Pro Ser Glu Ser Ile Leu Met
5 10 15TTG ATG GTT GCT TTT TTA TTG GTG CTG TTG AAC GCT TTT TTT GTG CTT 155Leu Met Val Ala Phe Leu Leu Val Leu Leu Asn Ala Phe Phe Val Leu
20 25 30TCA GAG TTT GCC CTT GTG AAA GTG CGT AAA ACC CGC TTA GAA GAG CTG 203Ser Glu Phe Ala Leu Val Lys Val Arg Lys Thr Arg Leu Glu Glu Leu
35 40 45GTT AAA ATC GGT AAT TCC AAC GCT AAA CTC GCT TTA AAG ATG AGT CAA 251Val Lys Ile Gly Asn Ser Asn Ala Lys Leu Ala Leu Lys Met Ser Gln50 55 60 65AGA CTA GAC ACT TAT TTG AGC GCG ACG CAG TTA GGC ATC ACC CTT TCT 299Arg Leu Asp Thr Tyr Leu Ser Ala Thr Gln Leu Gly Ile Thr Leu Ser
70 75 80TCA TTA GCT TTA GGC TGG GTG GGT GAG CCC GCT ATC GCA AAA TTG TTA 347Ser Leu Ala Leu Gly Trp Val Gly Glu Pro Ala Ile Ala Lys Leu Leu
85 90 95GCC GCG CTG TTT GAG TCT ATG GAT TTG AGA GAA AAT CCT ATT TTT ATC 395Ala Ala Leu Phe Glu Ser Met Asp Leu Arg Glu Asn Pro Ile Phe Ile
100 105 110CAT TCA ATG AGC GTG GTC ATA GCG TTT TTA AGC ATC ACT TTT TTG CAT 443His Ser Met Ser Val Val Ile Ala Phe Leu Ser Ile Thr Phe Leu His
115 120 125GTC GTG TTG GGC GAG ATT GTG CCT AAA TCT TTA GCG ATC GCT AAA TCT 491Val Val Leu Gly Glu Ile Val Pro Lys Ser Leu Ala Ile Ala Lys Ser130 135 140 145GAA AAA GCC ACC CTT TTT GCC GCA CGC CCT TTG CAT GTG TTT TGG GTG 539Glu Lys Ala Thr Leu Phe Ala Ala Arg Pro Leu His Val Phe Trp Val
150 155 160GTG TTT TAT CCG GTG GTG CGT TTG TTT GAT GTG ATC GCT CAT TTT TTT 587Val Phe Tyr Pro Val ValArg Leu Phe Asp Val Ile Ala His Phe Phe
165 170 175TTG AAA AAG ATG GGC ATC AAT CCT AAA GAG CAT GAC GGC ACG CAT TCT 635Leu Lys Lys Met Gly Ile Asn Pro Lys Glu His Asp Gly Thr His Ser
180 185 190GAA GAA GAG TTA AAA ATC ATT GTG GGC GAG AGT TTG AGA GAG GGC ATT 683Glu Glu Glu Leu Lys Ile Ile Val Gly Glu Ser Leu Arg Glu Gly Ile
195 200 205ATT GAT TCA GTG GAG GGC GAA ATC ATT AAA AAC GCA GTG GAT TTT TCT 731Ile Asp Ser Val Glu Gly Glu Ile Ile Lys Asn Ala Val Asp Phe Ser210 215 220 225GAC ACG AGC GCT AAA GAA ATC ATG ACC CCA CGA AAA GAC ATG GTG TGT 779Asp Thr Ser Ala Lys Glu Ile Met Thr Pro Arg Lys Asp Met Val Cys
230 235 240TTG GAT GAA GAA AAC AGC TAT GAA GAA AAT ATA GAC ATT GTT TTA AAA 827Leu Asp Glu Glu Asn Ser Tyr Glu Glu Asn Ile Asp Ile Val Leu Lys
245 250 255GGC CAT TTC ACG CGC TAC CCT TAT TGC AAG GGT TCT AAG GAT AAC ATT 875Gly His Phe Thr Arg Tyr Pro Tyr Cys Lys Gly Ser Lys Asp Asn Ile
260 265 270ATC GGC ATG GTG CAT ATT AGG GAT TTG CTT TCG CGC TCT ATT TTT ACC 923Ile Gly Met Val His Ile Arg Asp Leu Leu Ser Arg Ser Ile Phe Thr
275 280 285CCC AAA ATG CAT GAT TTC AAT CAA ATC GTT AGG AAA ATG ATC ATC GTC 971Pro Lys Met His Asp Phe Asn Gln Ile Val Arg Lys Met Ile Ile Val290 295 300 305CCC GAA AGC GCT TCC ATT TCT CAA ATC CTT ATT AAA ATG AAA AAA GAG 1019Pro Glu Ser Ala Ser Ile Ser Gln Ile Leu Ile Lys Met Lys Lys Glu
310 315 320CAA ATC CAT ACC GCT TTG GTG ATT GAT GAA TAC GGC GGC ACA GCC GGG 1067Gln Ile His Thr Ala Leu Val Ile Asp Glu Tyr Gly Gly Thr Ala Gly
325 330 335TTG CTC ACT ATG GAA GAC ATC ATT GAA GAG ATC ATG GGC GAG ATT AGC 1115Leu Leu Thr Met Glu Asp Ile Ile Glu Glu Ile Met Gly Glu Ile Ser
340 345 350GAC GAA TAC GAC TTA AAA CAA GAG GGC ATA AAC AAG CTT GAA GAG GGC 1163Asp Glu Tyr Asp Leu Lys Gln Glu Gly Ile Asn Lys Leu Glu Glu Gly
355 360 365GTG TTT GAA TTA GAG GGC ATG CTG GAT TTA GAG AGC GTA GAA GAA GCG 1211Val Phe Glu Leu Glu Gly Met Leu Asp Leu Glu Ser Val Glu Glu Ala370 375 380 385CTT CAC ATT GAA TTT GAT AAA GAA TGC GAG CAG GTA ACG CTT GGG GGC 1259Leu His Ile Glu Phe Asp Lys Glu Cys Glu Gln Val Thr Leu Gly Gly
390 395 400TAT GTT TTT AGC TTG TTA GAG CGC ATG CCT ATG GAG GGA GAT ACA ATC 1307Tyr Val Phe Ser Leu Leu Glu Arg Met Pro Met Glu Gly Asp Thr Ile
405 410 415GTT TCG CAT GGG TAT TCT TTT GAA GTC TTA AGC GTG GAT GGG GCT AGG 1355Val Ser His Gly Tyr Ser Phe Glu Val Leu Ser Val Asp Gly Ala Arg
420 425 430ATA AAA CGC TTA AAA GCG GTT AAA CAA GAT CAG GGA GAA AAT GAA GCA T 1404Ile Lys Arg Leu Lys Ala Val Lys Gln Asp Gln Gly Glu Asn Glu Ala
435 440 445GAAAAAAACA ACCCTCTTTG TATTGGGCTT ATTATTTAA 1443
(2) Sequence 1106 data:
(i) sequence characteristics:
(A) length: 449 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1106: met Gly Arg Asn Gln Gly Ala Tyr Leu Asp Pro Ser Glu Ser Ile Leu 151015 Met Leu Met Val Ala Phe Leu Leu Val Leu Leu Asn Ala Phe Phe Val
20 25 30Leu Ser Glu Phe Ala Leu Val Lys Val Arg Lys Thr Arg Leu Glu Glu
35 40 45Leu Val Lys Ile Gly Asn Ser Asn Ala Lys Leu Ala Leu Lys Met Ser
50 55 60Gln Arg Leu Asp Thr Tyr Leu Ser Ala Thr Gln Leu Gly Ile Thr Leu65 70 75 80Ser Ser Leu Ala Leu Gly Trp Val Gly Glu Pro Ala Ile Ala Lys Leu
85 90 95Leu Ala Ala Leu Phe Glu Ser Met Asp Leu Arg Glu Asn Pro Ile Phe
100 105 110Ile His Ser Met Ser Val Val Ile Ala Phe Leu Ser Ile Thr Phe Leu
115 120 125His Val Val Leu Gly Glu Ile Val Pro Lys Ser Leu Ala Ile Ala Lys
130 135 140Ser Glu Lys Ala Thr Leu Phe Ala Ala Arg Pro Leu His Val Phe Trp145 150 155 160Val Val Phe Tyr Pro Val Val Arg Leu Phe Asp Val Ile Ala His Phe
165 170 175Phe Leu Lys Lys Met Gly Ile Asn Pro Lys Glu His Asp Gly Thr His
180185 190Ser Glu Glu Glu Leu Lys Ile Ile Val Gly Glu Ser Leu Arg Glu Gly
195 200 205Ile Ile Asp Ser Val Glu Gly Glu Ile Ile Lys Asn Ala Val Asp Phe
210 215 220Ser Asp Thr Ser Ala Lys Glu Ile Met Thr Pro Arg Lys Asp Met Val225 230 235 240Cys Leu Asp Glu Glu Asn Ser Tyr Glu Glu Asn Ile Asp Ile Val Leu
245 250 255Lys Gly His Phe Thr Arg Tyr Pro Tyr Cys Lys Gly Ser Lys Asp Asn
260 265 270Ile Ile Gly Met Val His Ile Arg Asp Leu Leu Ser Arg Ser Ile Phe
275 280 285Thr Pro Lys Met His Asp Phe Ash Gln Ile Val Arg Lys Met Ile Ile
290 295 300Val Pro Glu Ser Ala Ser Ile Ser Gln Ile Leu Ile Lys Met Lys Lys305 310 315 320Glu Gln Ile His Thr Ala Leu Val Ile Asp Glu Tyr Gly Gly Thr Ala
325 330 335Gly Leu Leu Thr Met Glu Asp Ile Ile Glu Glu Ile Met Gly Glu Ile
340 345 350Ser Asp Glu Tyr Asp Leu Lys Gln Glu Gly lle Asn Lys Leu Glu Glu
355 360 365Gly Val Phe Glu Leu Glu Gly Met Leu Asp Leu Glu Ser Val Glu Glu
370 375 380Ala Leu His Ile Glu Phe Asp Lys Glu Cys Glu Gln Val Thr Leu Gly385 390 395 400Gly Tyr Val Phe Ser Leu Leu Glu Arg Met Pro Met Glu Gly Asp Thr
405 410415Ile Val Ser His Gly Tyr Ser Phe Glu Val Leu Ser Val Asp Gly Ala
420 425 430Arg Ile Lys Arg Leu Lys Ala Val Lys Gln Asp Gln Gly Glu Asn Glu
435 440 445Ala
(2) Sequence 1107 data:
(i) sequence characteristics:
(A) length: 394 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 47...367
(D) Other information:
(xi) Description of the sequence: sequence 1107: AGAAACCGGC ACGGTTACCA ACCAAGCGGT AACAATCTTT TTTAAA ATG GAG CGT 55
Met Glu Arg
1TTG ATC ACT TCT TCT TTA TAC ACT TTT TTA AGC GAC TTT TTT TCT TTC 103Leu Ile Thr Ser Ser Leu Tyr Thr Phe Leu Ser Asp Phe Phe Ser Phe
5 10 15TTT TTC AAT TCC AAA GCG ATG GCG GTG TTC TTG CTT TTT TTT AAG CTC 151Phe Phe Asn Ser Lys Ala Met Ala Val Phe Leu Leu Phe Phe Lys Leu20 25 30 35TCT AGC ATG AGC GAT TTT TCT TTC AAA TTG GCT TTA TCA AAG CGC TCT 199Ser Ser Met Ser Asp Phe Ser Phe Lys Leu Ala Leu Ser Lys Arg Ser
40 45 50AAA AAG CCT TCA ATT TCT TCT AAA TCT TCC CCA AAG TGC GCG GCT ACA 247Lys Lys Pro Ser Ile Ser Ser Lys Ser Ser Pro Lys Cys Ala Ala Thr
55 60 65ATG TTG TCT CTG ATT CTA GCA AAA CGC CTT CTT GAT TGC TCT CTT AAG 295Met Leu Ser Leu Ile Leu Ala Lys Arg Leu Leu Asp Cys Ser Leu Lys
70 75 80CGC TCC CTT AAA AAG CCC ACC CCA AAC ACC GCG CCC ACC ACA ATA TGC 343Arg Ser Leu Lys Lys Pro Thr Pro Asn Thr Ala Pro Thr Thr Ile Cys
85 90 95GTA GAG CTT ACG GGC AAG CCT AAT TGAGAGGCTA AAAGCACGGT GATGACT 394Val Glu Leu Thr Gly Lys Pro Asn100 105
(2) Sequence 1108 data:
(i) sequence characteristics:
(A) length: 107 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1108: met Glu Arg Leu Ile Thr Ser Ser Leu Tyr Thr Phe Leu Ser Asp Phe 151015 Phe Ser Phe Phe Phe Asn Ser Lys Ala Met Ala Val Phe Leu Leu Phe
20 25 30Phe Lys Leu Ser Ser Met Ser Asp Phe Ser Phe Lys Leu Ala Leu Ser
35 40 45Lys Arg Ser Lys Lys Pro Ser Ile Ser Ser Lys Ser Ser Pro Lys Cys
50 55 60Ala Ala Thr Met Leu Ser Leu Ile Leu Ala Lys Arg Leu Leu Asp Cys65 70 75 80Ser Leu Lys Arg Ser Leu Lys Lys Pro Thr Pro Asn Thr Ala Pro Thr
85 90 95Thr Ile Cys Val Glu Leu Thr Gly Lys Pro Asn
100 105
(2) Sequence 1109 data:
(i) sequence characteristics:
(A) length: 342 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...321
(D) Other information:
(xi) Description of the sequence: sequence l 109: TCAAATTCTT CATAA ATG ATT TTT TCT TTT AAA AGG ACT TCT TTT TGC GTG 51
Met Ile Phe Ser Phe Lys Arg Thr Ser Phe Cys Val
1 5 10AGC GTG CCG GTT TTG TCT ATA AAG ATT TTT TTC ACT TTA GCC AGA GTT 99Ser Val Pro Val Leu Ser Ile Lys Ile Phe Phe Thr Leu Ala Arg Val
15 20 25TCT AAA AAC AAC GCT TCT TTA AAC ACG ATC AAA GGG TTT TTA AAC ACC 147Ser Lys Asn Asn Ala Ser Leu Asn Thr Ile Lys Gly Phe Leu Asn Thr
30 35 40CCT ATC ACT AAC GCA ATG GGC GTA GCC AGA GCG AAC GCG CAA GGG CAG 195Pro Ile Thr Asn Ala Met Gly Val Ala Arg Ala Asn Ala Gln Gly Gln45 50 55 60CTG ATG ACT AGC ACG CTA ATA CAC ACC ATT AAG GCT TTT TCA AAA TTA 243Leu Met Thr Ser Thr Leu Ile His Thr Ile Lys Ala Phe Ser LysLeu
65 70 75CCC CCC AAA CCA AAT TGC CAT AAC AAA AAG CTT ACA AAG GCT AAA AAC 291Pro Pro Lys Pro Asn Cys His Asn Lys Lys Leu Thr Lys Ala Lys Asn
80 85 90AAC ACC GCT TTA GAA AAA ATA TCC GCA ATT TGATTCGCGC TACTCTCAAT T 342Asn Thr Ala Leu Glu Lys Ile Ser Ala Ile
95 100
(2) Sequence 1110 data:
(i) sequence characteristics:
(A) length: 102 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1110: met Ile Phe Ser Phe Lys Arg Thr Ser Phe Cys Val Ser Val Pro Val 151015 Leu Ser Ile Lys Ile Phe Phe Thr Leu Ala Arg Val Ser Lys Asn Asn
20 25 30Ala Ser Leu Asn Thr Ile Lys Gly Phe Leu Asn Thr Pro Ile Thr Asn
35 40 45Ala Met Gly Val Ala Arg Ala Asn Ala Gln Gly Gln Leu Met Thr Ser
50 55 60Thr Leu Ile His Thr Ile Lys Ala Phe Ser Lys Leu Pro Pro Lys Pro65 70 75 80Asn Cys His Asn Lys Lys Leu Thr Lys Ala Lys Asn Asn Thr Ala Leu
85 90 95Glu Lys Ile Ser Ala Ile
100
(2) Sequence 1111 data:
(i) sequencecharacteristics:
(A) length: 1108 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...1062
(D) Other information:
(xi) Description of the sequence: sequence 1111: AGGCTTTTTG CTCTTGCCTT TTTTCCCATC ATG AGA CTT TAT GAG AGT TTA TTA 54
Met Arg Leu Tyr Glu Ser Leu Leu
1 5GAA ATG TGC TTG AAT AAG GCA TGG GAG CAT CAA ACC CTA GCC TTA GAA 102Glu Met Cys Leu Asn Lys Ala Trp Glu His Gln Thr Leu Ala Leu Glu
10 15 20AAC CCA AGC GTA GCT TGC ATG GTG TTG GAT AAA AAC CAT GAG ATC TTG 150Asn Pro Ser Val Ala Cys Met Val Leu Asp Lys Asn His Glu Ile Leu25 30 35 40AGT TTA GAA ACC CAC AAA AAA GCC AAA ACC CCG CAT GCA GAA GTC TTA 198Ser Leu Glu Thr His Lys Lys Ala Lys Thr Pro His Ala Glu Val Leu
45 50 55GCC GCC CAA TCA GCG CTA AAG ATT TTA CGC CCC AGT TTG AAA AAC GAT 246Ala Ala Gln Ser Ala Leu Lys Ile Leu Arg Pro Ser Leu Lys Asn Asp
60 65 70TTA GAA AAG TTA GAA GAC CCT AAA ACT TTA AGC GAT TTT TTA AAA ACG 294Leu Glu Lys Leu Glu Asp Pro Lys Thr Leu Ser Asp Phe Leu Lys Thr
75 80 85CACCAC GAT AAC GCT TTT ACA GAC TGC GTT TTT TTA ATC ACC TTA GAG 342His His Asp Asn Ala Phe Thr Asp Cys Val Phe Leu Ile Thr Leu Glu
90 95 100CCA TGC AAT TCT TAT GGC AAA ACC CCG GCT TGT AGC GAA TTG TTA GAA 390Pro Cys Asn Ser Tyr Gly Lys Thr Pro Ala Cys Ser Glu Leu Leu Glu105 110 115 120ATT TTA AAG CCT AAA AGA GTG GTC ATT GCC ACA GAA GAA AAC GAA GCT 438Ile Leu Lys Pro Lys Arg Val Val Ile Ala Thr Glu Glu Asn Glu Ala
125 130 135AAA AAA GGG GGT TTA GCA AGG CTA CAA AAG GCT CGT ATT GAA ACA ATA 486Lys Lys Gly Gly Leu Ala Arg Leu Gln Lys Ala Arg Ile Glu Thr Ile
140 145 150ATT TGC CAC AAT TTA GAA AAC AAA GCT AAA GAC TTG CTC TTG CCT TTT 534Ile Cys His Asn Leu Glu Asn Lys Ala Lys Asp Leu Leu Leu Pro Phe
155 160 165AGG GTA ATG GAA CAA AAG GGG CGT TTT AAT TTG TTC AAA CTC GCT TTA 582Arg Val Met Glu Gln Lys Gly Arg Phe Asn Leu Phe Lys Leu Ala Leu
170 175 180AGA ATG AAT GGG GAT TAC CAT CAT GGC AAG ATC ACC GGG CAA AAA AGC 630Arg Met Asn Gly Asp Tyr His His Gly Lys Ile Thr Gly Gln Lys Ser185 190 195 200GTT ATT TTC ACG CAC AAC CAG CGA GCA ATA TGC GAC ACG CTT ATT GTT 678Val Ile Phe Thr His Asn Gln Arg Ala Ile Cys Asp Thr Leu Ile Val
205 210 215TCT GGG AAA ACC ATA AGA ACG GAC AAC CCC TTA TTG GAC GCT CGC TTT 726Ser Gly Lys Thr Ile Arg Thr Asp Asn Pro Leu Leu Asp Ala Arg Phe
220 225 230TGC GAC AGC TTT TAT CAA AAT AAA AAC CCC AAT ATC GCT ATT TTA TCC 774Cys Asp SerPhe Tyr Gln Asn Lys Asn Pro Asn Ile Ala Ile Leu Ser
235 240 245AAG CGC TCA ATT GAC CCT AAT TCA AAA GTT TTT TCT GCG CCT AAT CGT 822Lys Arg Ser Ile Asp Pro Asn Ser Lys Val Phe Ser Ala Pro Asn Arg
250 255 260TTA GTT AAC ACT TTC CAT GAC CCC AAA GAT TTA CCC CTA GAG AAG GGG 870Leu Val Asn Thr Phe His Asp Pro Lys Asp Leu Pro Leu Glu Lys Gly265 270 275 280TTT AAT TTC ATT GAA GGG GGG TGG GAA TTG TTT GAG AGC TTG AGG GAT 918Phe Asn Phe Ile Glu Gly Gly Trp Glu Leu Phe Glu Ser Leu Arg Asp
285 290 295AAA ATA GAC GCG TTG CTT TTG CAT TCG CAT GCG TCT ATG ATT GGC GAA 966Lys Ile Asp Ala Leu Leu Leu His Ser His Ala Ser Met Ile Gly Glu
300 305 310GCG TTT AAG GCA CTC GCT CTA AAA ACC CCT TTT AAA GGA CGG TTG TTG 1014Ala Phe Lys Ala Leu Ala Leu Lys Thr Pro Phe Lys Gly Arg Leu Leu
315 320 325CAT GCG CAA ATC TTA GAA AAT GAA GCC CTT TTA TGG ATA GAA AAC TCT T 1063His Ala Gln Ile Leu Glu Asn Glu Ala Leu Leu Trp Ile Glu Asn Ser
330 335 340AAGATTATAC CAGCCTTTGA ACGCTTATTC TTACAACAGC GATTC 1108
(2) Sequence 1112 data:
(i) sequence characteristics:
(A) length: 344 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1112: met Arg Leu Tyr Glu Ser Leu Leu Glu Met Cys Leu Asn Lys Ala Trp 151015 Glu His Gln Thr Leu Ala Leu Glu Asn Pro Ser Val Ala Cys Met Val
20 25 30Leu Asp Lys Asn His Glu Ile Leu Ser Leu Glu Thr His Lys Lys Ala
35 40 45Lys Thr Pro His Ala Glu Val Leu Ala Ala Gln Ser Ala Leu Lys Ile
50 55 60Leu Arg Pro Ser Leu Lys Asn Asp Leu Glu Lys Leu Glu Asp Pro Lys65 70 75 80Thr Leu Ser Asp Phe Leu Lys Thr His His Asp Asn Ala Phe Thr Asp
85 90 95Cys Val Phe Leu Ile Thr Leu Glu Pro Cys Asn Ser Tyr Gly Lys Thr
100 105 110Pro Ala Cys Ser Glu Leu Leu Glu Ile Leu Lys Pro Lys Arg Val Val
115 120 125Ile Ala Thr Glu Glu Asn Glu Ala Lys Lys Gly Gly Leu Ala Arg Leu
130 135 140Gln Lys Ala Arg Ile Glu Thr Ile Ile Cys His Asn Leu Glu Asn Lys145 150 155 160Ala Lys Asp Leu Leu Leu Pro Phe Arg Val Met Glu Gln Lys Gly Arg
165 170 175Phe Asn Leu Phe Lys Leu Ala Leu Arg Met Asn Gly Asp Tyr His His
180 185 190Gly Lys Ile Thr Gly Gln Lys Ser Val Ile Phe Thr His Asn Gln Arg
195 200 205Ala Ile Cys Asp Thr Leu Ile Val Ser Gly Lys Thr Ile Arg Thr Asp
210 215 220Asn Pro Leu Leu Asp Ala Arg Phe Cys Asp Ser Phe Tyr Gln Asn Lys225 230 235 240Asn Pro Asn Ile Ala Ile Leu Ser Lys Arg Ser Ile Asp Pro Asn Ser
245 250 255Lys Val Phe Ser Ala Pro Asn Arg Leu Val Asn Thr Phe His Asp Pro
260 265 270Lys Asp Leu Pro Leu Glu Lys Gly Phe Asn Phe Ile Glu Gly Gly Trp
275 280 285Glu Leu Phe Glu Ser Leu Arg Asp Lys Ile Asp Ala Leu Leu Leu His
290 295 300Ser His Ala Ser Met Ile Gly Glu Ala Phe Lys Ala Leu Ala Leu Lys305 310 315 320Thr Pro Phe Lys Gly Arg Leu Leu His Ala Gln Ile Leu Glu Asn Glu
325 330 335Ala Leu Leu Trp Ile Glu Asn Ser
340
(2) Sequence 1113 data:
(i) sequence characteristics:
(A) length: 823 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 14...799
(D) Other information:
(xi) Description of the sequence: sequence 1113: ACGATTTTAA AAA ATG GCT AGA AGT TTC AAG CAT TCT CAA TAT CCT AAA 49
Met Ala Arg Ser Phe Lys His Ser Gln Tyr Pro Lys
1 5 10ATT TTT AAG CCA CTA TAC CCT AAC AAC TTA ACG CTT TCA CTT AAA AAG 97Ile Phe Lys Pro Leu Tyr Pro Asn Asn Leu Thr Leu Ser Leu Lys Lys
15 20 25CAA CAT GTT ATA ATG ATC GCT ATT TTA TTT GAA AGG GTA TTT ATG GAA 145Gln His Val Ile Met Ile Ala Ile Leu Phe Glu Arg Val Phe Met Glu
30 35 40AGC GTT TTA AAT TTC CTA ACC AAT ATC AAT GTG ATT TTC ACC CTT TTG 193Ser Val Leu Asn Phe Leu Thr Asn Ile Asn Val Ile Phe Thr Leu Leu45 50 55 60GGC TAT TTG ATT GGG GGG ATT CCT TTT GGC TAT GCG TTA ATG AAA ATC 241Gly Tyr Leu Ile Gly Gly Ile Pro Phe Gly Tyr Ala Leu Met Lys Ile
65 70 75TTT TAC GGC ATG GAT ATT ACT AAA ATC GGA TCG GGG GGC ATT GGC GCA 289Phe Tyr Gly Met Asp Ile Thr Lys Ile Gly Ser Gly Gly Ile Gly Ala
80 85 90ACG AAT GTC TTG CGT GCT TTA CAA AGT AAG GGC GTG AGT AAC GCT AAA 337Thr Asn Val Leu Arg Ala Leu Gln Ser Lys Gly Val Ser Asn Ala Lys
95 100 105CAA ATG GCC CTA TTA GTT TTA ATC TTG GAT CTC TTC AAA GGC ATG TTT 385Gln Met Ala Leu Leu Val Leu Ile Leu Asp Leu Phe Lys Gly Met Phe
110 115 120GCA GTA TTT TTG AGC AAA TTG TTT GGG TTG GAT TAT AGT TTG CAA TGG 433Ala Val Phe Leu Ser Lys Leu Phe Gly Leu Asp Tyr Ser Leu Gln Trp125 130 135 140ATG GTC GCT ATC GCT AGC ATT TTA GGG CAT TGC TAT TCG CCT TTT TTG 481Met Val Ala Ile Ala Ser Ile Leu Gly His Cys Tyr Ser Pro Phe Leu
145 150 155AAT TTC AAT GGA GGT AAG GGC GTT TCT ACG ATC ATG GGC TCT GTG GTG 529Asn Phe Asn Gly Gly Lys Gly Val Ser Thr Ile Met Gly Ser Val Val
160 165 170TTG CTC ATC CCT ATT GAA AGT CTC ATC GGC TTA ACG GTG TGG TTT TTT 577Leu Leu Ile Pro Ile Glu Ser Leu Ile Gly Leu Thr Val Trp Phe Phe
175 180 185GTG GGT AAG GTG CTT AAA ATC TCT TCA CTC GCT AGC ATT CTA GGG GTA 625Val Gly Lys Val Leu Lys Ile Ser Ser Leu Ala Ser Ile Leu Gly Val
190 195 200GGC ACA GCG ACT GTT CTT ATC TTT TTT GTG CCT TAT ATG CAT ATC CCA 673Gly Thr Ala Thr Val Leu Ile Phe Phe Val Pro Tyr Met His Ile Pro205 210 215 220GAC AGC GTC AAT ATC CTT AAA GAA GTC GGC ACG CAA ACG CCG ATG GTG 721Asp Ser Val Asn Ile Leu Lys Glu Val Gly Thr Gln Thr Pro Met Val
225 230 235CTT ATT TTT ATT TTC ACC CTT ATC AAG CAT GCG GGT AAT ATT TTT AAT 769Leu Ile Phe Ile Phe Thr Leu Ile Lys His Ala Gly Asn Ile Phe Asn
240 245 250TTA TTG GCC GGC AAG GAA AAG AAA GTC TTA TGAAAACTAA ACAAGGCGTT CAT 822Leu Leu Ala Gly Lys Glu Lys Lys Val Leu
255 260
823
(2) Sequence 1114 data:
(i) sequence characteristics:
(A) length: 262 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1114: met Ala Arg Ser Phe Lys His Ser Gln Tyr Pro Lys Ile Phe Lys Pro 151015 Leu Tyr Pro Asn Asn Leu Thr Leu Ser Leu Lys Lys Gln His Val Ile
20 25 30Met Ile Ala Ile Leu Phe Glu Arg Val Phe Met Glu Ser Val Leu Asn
35 40 45Phe Leu Thr Asn Ile Asn Val Ile Phe Thr Leu Leu Gly Tyr Leu Ile
50 55 60Gly Gly Ile Pro Phe Gly Tyr Ala Leu Met Lys Ile Phe Tyr Gly Met65 70 75 80Asp Ile Thr Lys Ile Gly Ser Gly Gly Ile Gly Ala Thr Asn Val Leu
85 90 95Arg Ala Leu Gln Ser Lys Gly Val Ser Asn Ala Lys Gln Met Ala Leu
100 105 110Leu Val Leu Ile Leu Asp Leu Phe Lys Gly Met Phe Ala Val Phe Leu
115 120 125Ser Lys Leu Phe Gly Leu Asp Tyr Ser Leu Gln Trp Met Val Ala Ile
130 135 140Ala Ser Ile Leu Gly His Cys Tyr Ser Pro Phe Leu Asn Phe Asn Gly145 150 155 160Gly Lys Gly Val Ser Thr Ile Met Gly Ser Val Val Leu Leu Ile Pro
165 170 175Ile Glu Ser Leu Ile Gly Leu Thr Val Trp Phe Phe Val Gly Lys Val
180 185 190Leu Lys Ile Ser Ser Leu Ala Ser Ile Leu Gly Val Gly Thr Ala Thr
195 200 205Val Leu Ile Phe Phe Val Pro Tyr Met His Ile Pro Asp Ser Val Asn
210215 220Ile Leu Lys Glu Val Gly Thr Gln Thr Pro Met Val Leu Ile Phe Ile225 230 235 240Phe Thr Leu Ile Lys His Ala Gly Asn Ile Phe Asn Leu Leu Ala Gly
245 250 255Lys Glu Lys Lys Val Leu
260
(2) Sequence 1115 data:
(i) sequence characteristics:
(A) length: 404 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...381
(D) Other information:
(xi) Description of the sequence: sequence 1115: TTTATTGGCC GGCAAGGAAA AGAAAGTCTT ATG AAA ACT AAA CAA GGC GTT CAT 54
Met Lys Thr Lys Gln Gly Val His
1 5ATC CAT AAC TTG GTG TTT GAG GCG ATT TTG GGG ATT TTA GAA TTT GAA 102Ile His Asn Leu Val Phe Glu Ala Ile Leu Gly Ile Leu Glu Phe Glu
10 15 20CGC TTA AAA CCC CAA AAA ATA AGC GTG AAT TTG GAT CTT TTC TAC ACG 150Arg Leu Lys Pro Gln Lys Ile Ser Val Asn Leu Asp Leu Phe Tyr Thr25 30 35 40CAA TTA CCC AAT AAG GTT TAT TTA GAC TAC ATG GAA ATT CAA GAG CTT 198Gln Leu Pro Asn Lys Val Tyr Leu Asp Tyr Met Glu Ile Gln Glu Leu
45 5055ATT CAA AAG ATG ATG CAA GAA AAC CAA TAC CTT CTC ATT GAA GAC GCC 246Ile Gln Lys Met Met Gln Glu Asn Gln Tyr Leu Leu Ile Glu Asp Ala
60 65 70CTG AAA GAT TTG AGC CAT GCT TTA AAA ACG CGC TAC AAG GAG ATC ACT 294Leu Lys Asp Leu Ser His Ala Leu Lys Thr Arg Tyr Lys Glu Ile Thr
75 80 85GAA CTT TAT TTA AAA ATC AGC AAG TTA GAG ATT TCT CCC AAT TCT CAA 342Glu Leu Tyr Leu Lys Ile Ser Lys Leu Glu Ile Ser Pro Asn Ser Gln
90 95 100GTG GGA GCG AGC GTG AAA ATC CGC TAT GAA AGC AAT CTT TAGCCTCTTT TT 393Val Gly Ala Ser Val Lys Ile Arg Tyr Glu Ser Asn Leu105 110 115CCTTCTTATT G 404
(2) Sequence 1116 data:
(i) sequence characteristics:
(A) length: 117 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1116: met Lys Thr Lys Gln Gly Val His Ile His Asn Leu Val Phe Glu Ala 151015 Ile Leu Gly Ile Leu Glu Phe Glu Arg Leu Lys Pro Gln Lys Ile Ser
20 25 30Val Asn Leu Asp Leu Phe Tyr Thr Gln Leu Pro Asn Lys Val Tyr Leu
35 40 45Asp Tyr Met Glu Ile Gln Glu Leu Ile Gln Lys Met Met Gln Glu Asn
50 55 60Gln Tyr Leu Leu Ile Glu Asp Ala Leu Lys Asp Leu Ser HisAla Leu65 70 75 80Lys Thr Arg Tyr Lys Glu Ile Thr Glu Leu Tyr Leu Lys Ile Ser Lys
85 90 95Leu Glu Ile Ser Pro Asn Ser Gln Val Gly Ala Ser Val Lys Ile Arg
100 105 110Tyr Glu Ser Asn Leu
115
(2) Sequence 1117 data:
(i) sequence characteristics:
(A) length: 1227 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...1209
(D) Other information:
(xi) Description of the sequence: sequence 1117: TAAAATAACG CTTATTTTAA ACTCTCAAAA AAGGAATCAA ACGCACTCAT C ATG GCT 57
Met Ala
1AAA GAA ACG CTT GAA ATA ACC CCG GAT CTT TTG AAA AAC CCT TAT CAA 105Lys Glu Thr Leu Glu Ile Thr Pro Asp Leu Leu Lys Asn Pro Tyr Gln
5 10 15AAA ATC ATC AAT GCG AGC GCG AGC GTT TTT GAT GAA AAG CAT GGG CGA 153Lys Ile Ile Asn Ala Ser Ala Ser Val Phe Asp Glu Lys His Gly Arg
20 25 30TCG TTT TTT AGC ACG CAA TTT TAT GAA AAA ATT GAA CCT TAT TTA AAA 201Ser Phe Phe Ser Thr Gln Phe Tyr Glu Lys Ile Glu Pro Tyr Leu Lys35 40 45 50GAA GTT TTA ACC CAT CCC ATT GAT TTA GAA TGC GAT CTA AAC ACC GCT 249Glu Val Leu Thr His Pro Ile Asp Leu Glu Cys Asp Leu Asn Thr Ala
55 60 65AAA AAA AAG AAC CGC TTA ACC CCT TTA AAA CAG CTT TTT AAA GCG TGT 297Lys Lys Lys Asn Arg Leu Thr Pro Leu Lys Gln Leu Phe Lys Ala Cys
70 75 80TTT AAC ACC GAA GAA ATT TTG ATT GTG AAT AAT AAC ACC AGC GCG ATT 345Phe Asn Thr Glu Glu Ile Leu Ile Val Asn Asn Asn Thr Ser Ala Ile
85 90 95TTC CTC ATC GCT AAC GCT TTA GCG CAA GAA AAA GAA ATC ATT GTT TCT 393Phe Leu Ile Ala Asn Ala Leu Ala Gln Glu Lys Glu Ile Ile Val Ser
100 105 110TAT GGC GAA TTA GTG GGG GGG GAT TTT AAC CTT AAA GAT ATT TTA TTA 441Tyr Gly Glu Leu Val Gly Gly Asp Phe Asn Leu Lys Asp Ile Leu Leu115 120 125 130AAT AGT GGG GCT AGG CTG CAT TTA GTG GGG AAT ATT AAT CGC GCT TAT 489Asn Ser Gly Ala Arg Leu His Leu Val Gly Asn Ile Asn Arg Ala Tyr
135 140 145TTA AGG GAT TAC CGC TTA GCC TTG AAT GAA AAC AGC AAA ATA CTC TTT 537Leu Arg Asp Tyr Arg Leu Ala Leu Asn Glu Asn Ser Lys Ile Leu Phe
150 155 160AAA ACC CAC AAC CCC CAT TTT AAA AAA GAC ACG CCC TTT AAA GAT TTA 585Lys Thr His Asn Pro His Phe Lys Lys Asp Thr Pro Phe Lys Asp Leu
165 170 175CAA ACT CTT GCT AAA GAG CAT GAT CTC ATT GAT TAT TAC AAT TTA GGG 633Gln Thr Leu Ala Lys Glu His Asp Leu Ile Asp Tyr Tyr Asn Leu Gly
180 185 190GAT GTG GAT TTG TCA AAC AGA GTG GCT TTG GAA GAA ATT TTA GCC CTA 681Asp Val Asp Leu Ser Asn Arg Val Ala Leu Glu Glu Ile Leu Ala Leu195 200 205 210AAA CCA TCG CTT TTA AGC TTT AGC GCG GAT AAA TTC TTT AAC AGT GCG 729Lys Pro Ser Leu Leu Ser Phe Ser Ala Asp Lys Phe Phe Asn Ser Ala
215 220 225CAA GCG GGC ATT ATT ATG GGG CAA AAA GAA CGG GTT GAA GCG TTA AAA 777Gln Ala Gly Ile Ile Met Gly Gln Lys Glu Arg Val Glu Ala Leu Lys
230 235 240AAC CAC CCC CTT TAT AGA GTT TTA AGG GTG GGT AAA ATC ACG CTC ACC 825Asn His Pro Leu Tyr Arg Val Leu Arg Val Gly Lys Ile Thr Leu Thr
245 250 255TTG CTT TTT TGC AGC CTA AAA GCA TGG ATA AAT CAT CAA GAA GAC ATT 873Leu Leu Phe Cys Ser Leu Lys Ala Trp Ile Asn His Gln Glu Asp Ile
260 265 270ACA ATC CAT GCG TTA TTG AAC CAA ACT AAA GAC GCA TTA TTG CAA AAA 921Thr Ile His Ala Leu Leu Asn Gln Thr Lys Asp Ala Leu Leu Gln Lys275 280 285 290GCC CTC AAA CTC TAC GCT CTT TTA AAG CCT TTA GAA TTG AAT GTG AGC 969Ala Leu Lys Leu Tyr Ala Leu Leu Lys Pro Leu Glu Leu Asn Val Ser
295 300 305ATA GCC TCT AGC TTT TCT AAA ATA GGG AAT TTG TTT GGT AGG GAA TTA 1017Ile Ala Ser Ser Phe Ser Lys Ile Gly Asn Leu Phe Gly Arg Glu Leu
310 315 320GAA TCC TTT TGC GTG AAA ATC CAG CCC AAA AAC ACC CGT GCT TTA AAT 1065Glu Ser Phe Cys Val Lys Ile Gln Pro Lys Asn Thr Arg Ala Leu Asn
325 330 335AGT GAG AAA CTT TAT TTA AAG CTT TTC CAA AAA GGC GTT ATC GCA AGG 1113Ser Glu Lys Leu Tyr Leu Lys Leu Phe Gln Lys Gly Val Ile Ala Arg
340 345 350ATT TCA TGC GAA TTC GTG TGC TTT GAA GTC TTT AGC TTG AAT GAA AAA 1161Ile Ser Cys Glu Phe Val Cys Phe Glu Val Phe Ser Leu Asn Glu Lys355 360 365 370GAT TTT GAA AAA ATC GCT CTG GTT TTA GAA GAA ATT CTT AAT AAA GCT T 1210Asp Phe Glu Lys Ile Ala Leu Val Leu Glu Glu Ile Leu Asn Lys Ala
375 380 385AAAAATTCGC TATAATA 1227
(2) Sequence 1118 data:
(i) sequence characteristics:
(A) length: 386 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1118: met Ala Lys Glu Thr Leu Glu Ile Thr Pro Asp Leu Leu Lys Asn Pro 151015 Tyr Gln Lys Ile Ile Asn Ala Ser Ala Ser Val Phe Asp Glu Lys His
20 25 30Gly Arg Ser Phe Phe Ser Thr Gln Phe Tyr Glu Lys Ile Glu Pro Tyr
35 40 45Leu Lys Glu Val Leu Thr His Pro Ile Asp Leu Glu Cys Asp Leu Asn
50 55 60Thr Ala Lys Lys Lys Asn Arg Leu Thr Pro Leu Lys Gln Leu Phe Lys65 70 75 80Ala Cys Phe Asn Thr Glu Glu Ile Leu Ile Val Asn Asn Asn Thr Ser
85 9095Ala Ile Phe Leu Ile Ala Asn Ala Leu Ala Gln Glu Lys Glu Ile Ile
100 105 110Val Ser Tyr Gly Glu Leu Val Gly Gly Asp Phe Asn Leu Lys Asp Ile
115 120 125Leu Leu Asn Ser Gly Ala Arg Leu His Leu Val Gly Asn Ile Asn Arg
130 135 140Ala Tyr Leu Arg Asp Tyr Arg Leu Ala Leu Asn Glu Asn Ser Lys Ile145 150 155 160Leu Phe Lys Thr His Asn Pro His Phe Lys Lys Asp Thr Pro Phe Lys
165 170 175Asp Leu Gln Thr Leu Ala Lys Glu His Asp Leu Ile Asp Tyr Tyr Asn
180 185 190Leu Gly Asp Val Asp Leu Ser Asn Arg Val Ala Leu Glu Glu Ile Leu
195 200 205Ala Leu Lys Pro Ser Leu Leu Ser Phe Ser Ala Asp Lys Phe Phe Asn
210 215 220Ser Ala Gln Ala Gly Ile Ile Met Gly Gln Lys Glu Arg Val Glu Ala225 230 235 240Leu Lys Asn His Pro Leu Tyr Arg Val Leu Arg Val Gly Lys Ile Thr
245 250 255Leu Thr Leu Leu Phe Cys Ser Leu Lys Ala Trp Ile Asn His Gln Glu
260 265 270Asp Ile Thr Ile His Ala Leu Leu Asn Gln Thr Lys Asp Ala Leu Leu
275 280 285Gln Lys Ala Leu Lys Leu Tyr Ala Leu Leu Lys Pro Leu Glu Leu Asn
290 295 300Val Ser Ile Ala Ser Ser Phe Ser Lys Ile Gly Asn Leu Phe Gly Arg305 310 315 320Glu Leu Glu Ser Phe Cys Val Lys Ile Gln Pro Lys Asn Thr Arg Ala
325 330 335Leu Asn Ser Glu Lys Leu Tyr Leu Lys Leu Phe Gln Lys Gly Val Ile
340 345 350Ala Arg Ile Ser Cys Glu Phe Val Cys Phe Glu Val Phe Ser Leu Asn
355 360 365Glu Lys Asp Phe Glu Lys Ile Ala Leu Val Leu Glu Glu Ile Leu Asn
370 375 380Lys Ala385
(2) Sequence 1119 data:
(i) sequence characteristics:
(A) length: 1238 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 13...1197
(D) Other information:
(xi) Description of the sequence: sequence 1119: AGGAACTTAA GA ATG GAA AAA ATC AGC GAT CTT ATA GAA TGC ATT GCG TAT 51
Met Glu Lys Ile Ser Asp Leu Ile Glu Cys Ile Ala Tyr
1 5 10GAA AAA AAT TTG CCT AAA GAG ATG ATT TCA AAA GTG ATT CAA GGC TGT 99Glu Lys Asn Leu Pro Lys Glu Met Ile Ser Lys Val Ile Gln Gly Cys
15 20 25TTG TTA AAA ATG GCG CAA AAT GAG TTA GAC CCC CTA GCA CGC TAC TTG 147Leu Leu Lys Met Ala Gln Asn Glu Leu Asp Pro Leu Ala Arg Tyr Leu3035 40 45GTG GTT GAA GAA AAC AAG CAG CTC CAG CTT ATC CAG TTG GTA GAA GTT 195Val Val Glu Glu Asn Lys Gln Leu Gln Leu Ile Gln Leu Val Glu Val
50 55 60TTA GAA GAT GGT GAT GAA AGA TTG GTT AAC GAC CCT TCT AAA TAC ATC 243Leu Glu Asp Gly Asp Glu Arg Leu Val Asn Asp Pro Ser Lys Tyr Ile
65 70 75AGC CTG TCT AAA GCC AAA GAA ATG GAT CCA AGC GTT AAG ATT AAA GAC 291Ser Leu Ser Lys Ala Lys Glu Met Asp Pro Ser Val Lys Ile Lys Asp
80 85 90GAA TTG TCC TAT AGC TTG AGT TTG GAG AGC ATG AAA CAA GGA GCG ATC 339Glu Leu Ser Tyr Ser Leu Ser Leu Glu Ser Met Lys Gln Gly Ala Ile
95 100 105AAC CGC CTT TTT AAA GAT TTG CAA TAC CAG TTA GAA AAA GCG TTA GAA 387Asn Arg Leu Phe Lys Asp Leu Gln Tyr Gln Leu Glu Lys Ala Leu Glu110 115 120 125GAC AGC CAC TTT GAA GCG TTT CAA AAG CGT CTT AAC AGC GTT TTA ATG 435Asp Ser His Phe Glu Ala Phe Gln Lys Arg Leu Asn Ser Val Leu Met
130 135 140GGG CAA GTG ATT TTA GTG GAT CAC AAC CAA AAC ACC TTT ATT GAG ATT 483Gly Gln Val Ile Leu Val Asp His Asn Gln Asn Thr Phe Ile Glu Ile
145 150 155GAG CAG CAA TTT CAG GGC GTT CTT TCC ATG CGC CAT CGC ATC AAG GGC 531Glu Gln Gln Phe Gln Gly Val Leu Ser Met Arg His Arg Ile Lys Gly
160 165 170GAG AGT TTT AAA GTG GGC GAT AGC ATT AAA GCG GTT TTA ACG CAA GTC 579Glu Ser Phe Lys Val Gly Asp Ser Ile Lys Ala Val Leu Thr Gln Val
175 180 185AAA CGC ACG AAA AAA GGC TTA TTA TTA GAG CTG AGC CGC ACC ACC CCT 627Lys Arg Thr Lys Lys Gly Leu Leu Leu Glu Leu Ser Arg Thr Thr Pro190 195 200 205AAA ATG CTT GAA GCT TTG TTG GAA TTG GAA GTC CCT GAA ATT AAA GAC 675Lys Met Leu Glu Ala Leu Leu Glu Leu Glu Val Pro Glu Ile Lys Asp
210 215 220AAA GAA ATT GAA ATC ATC CAT TGT GCG CGA ATC CCA GGC AAC AGA GCG 723Lys Glu Ile Glu Ile Ile His Cys Ala Arg Ile Pro Gly Asn Arg Ala
225 230 235AAA GTG AGC TTT TTT TCC CAT AAC GCT AGG ATT GAC CCC ATA GGC GCG 771Lys Val Ser Phe Phe Ser His Asn Ala Arg Ile Asp Pro Ile Gly Ala
240 245 250GCT GTG GGG GTT AAG GGC GTG CGC ATT AAT GCG ATC AGT AAC GAA TTG 819Ala Val Gly Val Lys Gly Val Arg Ile Asn Ala Ile Ser Asn Glu Leu
255 260 265AAT AAA GAA AAC ATT GAT TGC ATA GAA TAT TCT AAT GTG CCT GAA ATT 867Asn Lys Glu Asn Ile Asp Cys Ile Glu Tyr Ser Asn Val Pro Glu Ile270 275 280 285TAC ATC ACT CTC GCA CTC GCT CCA GCC AAA ATT TTA AGC GTT GAA ATC 915Tyr Ile Thr Leu Ala Leu Ala Pro Ala Lys Ile Leu Ser Val Glu Ile
290 295 300AAA AAA ATC CCT ATA GAA GAA TTG AAT GCT GAA GAA AAA GAA TCC ATT 963Lys Lys Ile Pro Ile Glu Glu Leu Asn Ala Glu Glu Lys Glu Ser Ile
305 310 315CAA GAG CGT TTT ATC GTC AAT AAC CAT TTG CAA AAG GCT AAA GTG CGT 1011Gln Glu Arg Phe Ile Val Asn Asn His Leu Gln Lys Ala Lys Val Arg
320 325 330TTA TTG GAC ATT GAA AAA TCT AAG GCT ATC GGT AAG GGC GGG GTG AAT 1059Leu Leu Asp IleGlu Lys Ser Lys Ala Ile Gly Lys Gly Gly Val Asn
335 340 345GTG TGC TTA GCG TCC ATG CTT ACA GGC TAT CAC ATA GAG TTT GAA ACC 1107Val Cys Leu Ala Ser Met Leu Thr Gly Tyr His Ile Glu Phe Glu Thr350 355 360 365ATT CCT AGC GTG AAA GAA AAC GCA GAA AAT GAA AGC GAA AAA GAA ACG 1155Ile Pro Ser Val Lys Glu Asn Ala Glu Asn Glu Ser Glu Lys Glu Thr
370 375 380CCA AAA GTG GGG GTA GAA GCT TTA GAG TCT TTG TTT AAG AAT TAAGGGTAT 1206Pro Lys Val Gly Val Glu Ala Leu Glu Ser Leu Phe Lys Asn
385 390 395CTAAAATTCA ATCTCTAAAA AAGCTTTTAA CT 1238
(2) Sequence 1120 data:
(i) sequence characteristics:
(A) length: 395 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1120: met Glu Lys Ile Ser Asp Leu Ile Glu Cys Ile Ala Tyr Glu Lys Asn 151015 Leu Pro Lys Glu Met Ile Ser Lys Val Ile Gln Gly Cys Leu Leu Lys
20 25 30Met Ala Gln Asn Glu Leu Asp Pro Leu Ala Arg Tyr Leu Val Val Glu
35 40 45Glu Asn Lys Gln Leu Gln Leu Ile Gln Leu Val Glu Val Leu Glu Asp
50 55 60Gly Asp Glu Arg Leu Val Asn Asp Pro Ser Lys Tyr Ile Ser Leu Ser65 70 7580Lys Ala Lys Glu Met Asp Pro Ser Val Lys Ile Lys Asp Glu Leu Ser
85 90 95Tyr Ser Leu Ser Leu Glu Ser Met Lys Gln Gly Ala Ile Asn Arg Leu
100 105 110Phe Lys Asp Leu Gln Tyr Gln Leu Glu Lys Ala Leu Glu Asp Ser His
115 120 125Phe Glu Ala Phe Gln Lys Arg Leu Asn Ser Val Leu Met Gly Gln Val
130 135 140Ile Leu Val Asp His Asn Gln Asn Thr Phe Ile Glu Ile Glu Gln Gln145 150 155 160Phe Gln Gly Val Leu Ser Met Arg His Arg Ile Lys Gly Glu Ser Phe
165 170 175Lys Val Gly Asp Ser Ile Lys Ala Val Leu Thr Gln Val Lys Arg Thr
180 185 190Lys Lys Gly Leu Leu Leu Glu Leu Ser Arg Thr Thr Pro Lys Met Leu
195 200 205Glu Ala Leu Leu Glu Leu Glu Val Pro Glu Ile Lys Asp Lys Glu Ile
210 215 220Glu Ile Ile His Cys Ala Arg Ile Pro Gly Asn Arg Ala Lys Val Ser225 230 235 240Phe Phe Ser His Asn Ala Arg Ile Asp Pro Ile Gly Ala Ala Val Gly
245 250 255Val Lys Gly Val Arg Ile Asn Ala Ile Ser Asn Glu Leu Asn Lys Glu
260 265 270Asn Ile Asp Cys Ile Glu Tyr Ser Asn Val Pro Glu Ile Tyr Ile Thr
275 280 285Leu Ala Leu Ala Pro Ala Lys Ile Leu Ser Val Glu Ile Lys Lys Ile
290 295 300Pro Ile Glu Glu Leu Asn Ala Glu Glu Lys Glu Ser Ile Gln Glu Arg305 310 315 320Phe Ile Val Asn Asn His Leu Gln Lys Ala Lys Val Arg Leu Leu Asp
325 330 335Ile Glu Lys Ser Lys Ala Ile Gly Lys Gly Gly Val Asn Val Cys Leu
340 345 350Ala Ser Met Leu Thr Gly Tyr His Ile Glu Phe Glu Thr Ile Pro Ser
355 360 365Val Lys Glu Asn Ala Glu Asn Glu Ser Glu Lys Glu Thr Pro Lys Val
370 375 380Gly Val Glu Ala Leu Glu Ser Leu Phe Lys Asn385 390 395
(2) Data of sequence 1121:
(i) sequence characteristics:
(A) length: 3903bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 21...3857
(D) Other information:
(xi) Description of the sequence: sequence 1121: AAGCGATGTA AGGAATTAAC ATG GAT TAT AAA AAA TTA GAT TTA CCC AAC 50
Met Asp Tyr Lys Lys Leu Asp Leu Pro Asn
1 5 10ACA AAC TAC CCA AAT CAA GAG CAA CTG AAA GCT TTT GAA ACC GCT TTT 98Thr Asn Tyr Pro Asn Gln Glu Gln Leu Lys Ala Phe Glu Thr Ala Phe
15 20 25GAC GCC TTT TTA GAA ACC AAC CAA CAA GAA AAT GAA AAT CAC CAA AAC 146Asp Ala Phe Leu Glu Thr Asn Gln Gln Glu Asn Glu Asn His Gln Asn
30 35 40GAC GCT TTT AAT GAT TTA TTG AAA GGC GTT TTT AAA TAC AAG GTT AAG 194Asp Ala Phe Asn Asp Leu Leu Lys Gly Val Phe Lys Tyr Lys Val Lys
45 50 55CCC ACC AAA AAA ATA GAC AGC ACT ATT CTT AAT GAA AAT AAC GAA GTG 242Pro Thr Lys Lys Ile Asp Ser Thr Ile Leu Asn Glu Asn Asn Glu Val
60 65 70GAG GTG ATC ATT GAA TTT AAA GCC CTT AAA AAC CCC AAC GAA TTT ATT 290Glu Val Ile Ile Glu Phe Lys Ala Leu Lys Asn Pro Asn Glu Phe Ile75 80 85 90AAA AAG GGC GAT TTG AAT GTT AAA GCC TTT CAT GAA AGC CTT TTG TCT 338Lys Lys Gly Asp Leu Asn Val Lys Ala Phe His Glu Ser Leu Leu Ser
95 100 105TAT CTC ACA GAA AGA AAA GAG GGT AAT AAC AAC CTT AAG CAT CTT ATC 386Tyr Leu Thr Glu Arg Lys Glu Gly Asn Asn Asn Leu Lys His Leu Ile
110 115 120TTA GCC ACT ATT AAA GAG CTT TAT ATC ATT GAT GCA AAC GAA TTT GAG 434Leu Ala Thr Ile Lys Glu Leu Tyr Ile Ile Asp Ala Asn Glu Phe Glu
125 130 135GTT TTT AAT AAA GAT AAA GAA ATT GAA AAC GCC TTT AAA AAT TGC CAC 482Val Phe Asn Lys Asp Lys Glu Ile Glu Asn Ala Phe Lys Asn Cys His
140 145 150GAT AGA AAG GGT AAC GAT ACA CGC ACA AAA GCG TTT TAT GAT GCT TGC 530Asp Arg Lys Gly Asn Asp Thr Arg Thr Lys Ala Phe Tyr Asp Ala Cys155 160 165170CAA AAG CGC CTT AAT GAG TTT GAT CGT TCT TTG AAA TAC CAC TAT ATC 578Gln Lys Arg Leu Asn Glu Phe Asp Arg Ser Leu Lys Tyr His Tyr Ile
175 180 185CCC CTC AAA AAA GAA AAT TTA GCC CTA ATC TAT CAA GCC CTA AGC CCT 626Pro Leu Lys Lys Glu Asn Leu Ala Leu Ile Tyr Gln Ala Leu Ser Pro
190 195 200AAT TTT TTG CTC AAA ATT CCA AAA TAT TCT GAC GCT AAC ACG CTT AAC 674Asn Phe Leu Leu Lys Ile Pro Lys Tyr Ser Asp Ala Asn Thr Leu Asn
205 210 215AAA GAT TTT TAT GAA GAA TTG CTT TAC ATT TTA GGG TTA GAA GAG CAA 722Lys Asp Phe Tyr Glu Glu Leu Leu Tyr Ile Leu Gly Leu Glu Glu Gln
220 225 230AAT GAC AAA GGG AAA ATT TTA ATC AAG CCC AGC CGC ACC CAA AAT TCC 770Asn Asp Lys Gly Lys Ile Leu Ile Lys Pro Ser Arg Thr Gln Asn Ser235 240 245 250CTA AGC GAT GCT TTA AAA AAG GAA TAC AAA AAT TTA GAC GAT GAA GAA 818Leu Ser Asp Ala Leu Lys Lys Glu Tyr Lys Asn Leu Asp Asp Glu Glu
255 260 265GTC ATG GCG TTG CTC ATC GCT TGG AAT AAC CGC ATC TTG TTT TTA CGG 866Val Met Ala Leu Leu Ile Ala Trp Asn Asn Arg Ile Leu Phe Leu Arg
270 275 280CTT TTA GAA AGC CTT TTA ATT TCT TTT AAG CAT TTT GAA AAT CCT TTC 914Leu Leu Glu Ser Leu Leu Ile Ser Phe Lys His Phe Glu Asn Pro Phe
285 290 295TTA ACC ACA GAA AAC TTT GAA AAT TTC AAC GAT TTA AAC ACG CTC TTT 962Leu Thr Thr Glu Asn Phe Glu Asn Phe Asn Asp Leu Asn Thr Leu Phe
300 305 310TTT GAA GTC CTA GCC AAG AAA AAC AGC GAG CGC TTA CCA GAA ATT AAA 1010Phe Glu Val Leu Ala Lys Lys Asn Ser Glu Arg Leu Pro Glu Ile Lys315 320 325 330GAA GAC AAG ATT TTA GAA AAA ATC CCT TAT TTG AAT TCC AGT TTG TTT 1058Glu Asp Lys Ile Leu Glu Lys Ile Pro Tyr Leu Asn Ser Ser Leu Phe
335 340 345GAT AAA ACG CCT TTA GAA TTA AAG GGG CAT GAA ATC AAG CTT TTA GAC 1106Asp Lys Thr Pro Leu Glu Leu Lys Gly His Glu Ile Lys Leu Leu Asp
350 355 360AAT AAA AAG CTA GAA ATC TAT AAA AAT TCC GTT CTC AAA AAA CAT AAA 1154Asn Lys Lys Leu Glu Ile Tyr Lys Asn Ser Val Leu Lys Lys His Lys
365 370 375GAT TAT CAA AAA GAA AAA CCT TTG CCC TTG CTA AAA TAC CTT TTT AAA 1202Asp Tyr Gln Lys Glu Lys Pro Leu Pro Leu Leu Lys Tyr Leu Phe Lys
380 385 390TTT TTG CGT CTT TAT AAA TTC ACC ACC ACC CCT AAA GAC ATT AAA GAT 1250Phe Leu Arg Leu Tyr Lys Phe Thr Thr Thr Pro Lys Asp Ile Lys Asp395 400 405 410AAT ACC GAT ACC AGC GAA AGC CGT TTG ATT AAC CCT AGC GTT TTA GGG 1298Asn Thr Asp Thr Ser Glu Ser Arg Leu Ile Asn Pro Ser Val Leu Gly
415 420 425CTT GTT TTT GAA AAA CTC AAC GGC TAT AAA GAG GGG AGC TTT TAT ACC 1346Leu Val Phe Glu Lys Leu Asn Gly Tyr Lys Glu Gly Ser Phe Tyr Thr
430 435 440CCA AGC TTT ATC ACA AGC TAC ATG TGC AAA GAG AGC ATC ACG CCC ATC 1394Pro Ser Phe Ile Thr Ser Tyr Met Cys Lys Glu Ser Ile Thr Pro Ile
445 450 455GTG TTG GAT AAA TTC AAC GCC ATT TAT CAG TGG GAC TGC GAA AAT CTA 1442Val Leu Asp Lys PheAsn Ala Ile Tyr Gln Trp Asp Cys Glu Asn Leu
460 465 470AAA GCG TTG CGA GGA GAA ATA GAC AGA AAT TTT TCA AAT GAA AAA GCT 1490Lys Ala Leu Arg Gly Glu Ile Asp Arg Asn Phe Ser Asn Glu Lys Ala475 480 485 490AAA GAA TAC CTA AAC ACG CTT TTA ACC TTG CGT ATT TGC GAT CCG GCG 1538Lys Glu Tyr Leu Asn Thr Leu Leu Thr Leu Arg Ile Cys Asp Pro Ala
495 500 505GTG GGG AGC GGG CAT TTC TTG GTT TCA GCG CTC AAT GAA ATG GTG CGG 1586Val Gly Ser Gly His Phe Leu Val Ser Ala Leu Asn Glu Met Val Arg
510 515 520GTT GCT TAT GAG CTA GGA CTT ATT GCT TCC TTG TAT CGC TAC GAT CTT 1634Val Ala Tyr Glu Leu Gly Leu Ile Ala Ser Leu Tyr Arg Tyr Asp Leu
525 530 535AAA TTA GAA AAC GAT GAA ATC ATC ATT CAC CAC ACG CCA ACG GGT GAA 1682Lys Leu Glu Asn Asp Glu Ile Ile Ile His His Thr Pro Thr Gly Glu
540 545 550ATC TTT AAC TAC ATA AAA CCA GAT AGC GAA AAC GAC CCC CAC CAC CAC 1730Ile Phe Asn Tyr Ile Lys Pro Asp Ser Glu Asn Asp Pro His His His555 560 565 570ATC CAA AAA GAA CTT TTT AAT CTT AAA AAA TCC ATT ATT GAA AAC TGC 1778Ile Gln Lys Glu Leu Phe Asn Leu Lys Lys Ser Ile Ile Glu Asn Cys
575 580 585CTT TTT GGC GTG GAT ATT AAC CCC AAT TCT TGC GAA ATC ACC AAG CTC 1826Leu Phe Gly Val Asp Ile Asn Pro Asn Ser Cys Glu Ile Thr Lys Leu
590 595 600AGG CTA TGG ATA GAG CTT TTA AAA TAC AGC TAT TAT ATT TTT GAA AAG 1874Arg Leu Trp Ile Glu Leu Leu Lys Tyr Ser Tyr Tyr Ile Phe Glu Lys
605 610 615GGC AAG AAC ACT AAC GCG CTT GAA ACC CTC CCC AAC ATT GAT ATT AAC 1922Gly Lys Asn Thr Asn Ala Leu Glu Thr Leu Pro Asn Ile Asp Ile Asn
620 625 630ATT AAG TGC GCT AAT TCG CTC ATT TCT AGG TTT GCC CTC AAA GAT AAA 1970Ile Lys Cys Ala Asn Ser Leu Ile Ser Arg Phe Ala Leu Lys Asp Lys635 640 645 650GCC TTG TTA AAA AGC GAA AAA AAT AAA AAC CTA GAA TAC TCT ATC GCT 2018Ala Leu Leu Lys Ser Glu Lys Asn Lys Asn Leu Glu Tyr Ser Ile Ala
655 660 665GAA TAC AAA GAA CTC GTT AAA ATC TAT AAA GAC CCT AAA ATC TTA GAA 2066Glu Tyr Lys Glu Leu Val Lys Ile Tyr Lys Asp Pro Lys Ile Leu Glu
670 675 680ACC CTA ACG CAC CCC ATA AAA GAC TCT AAC GCC GTT AGA AAA TAC GCT 2114Thr Leu Thr His Pro Ile Lys Asp Ser Asn Ala Val Arg Lys Tyr Ala
685 690 695AAA GAA CGC CTT TAT CAA GAA CTA AAA CAA AAT CCT AAC AAA GAT TTT 2162Lys Glu Arg Leu Tyr Gln Glu Leu Lys Gln Asn Pro Asn Lys Asp Phe
700 705 710AAA AAG GCT CTC AAT GAT AGG ATA GAG AAA ATT AAA AAA GCT TTT AAA 2210Lys Lys Ala Leu Asn Asp Arg Ile Glu Lys Ile Lys Lys Ala Phe Lys715 720 725 730CTC ACT TTA AAC CCC CCT CCA AAA GAA TTA AAA TTT AAA AAA TTT TTA 2258Leu Thr Leu Asn Pro Pro Pro Lys Glu Leu Lys Phe Lys Lys Phe Leu
735 740 745AAA GAG CAT TTA GAA CTC TAT GGC AAG AGT ATC TTA GAA GAG GCA AAC 2306Lys Glu His Leu Glu Leu Tyr Gly Lys Ser Ile Leu Glu Glu Ala Asn
750 755 760TAC AAC GGC TTA GAA TTG GAA GCC CTA GCA TTA GAA AAG CAA ATG GCG 2354Tyr Asn Gly Leu Glu Leu Glu Ala Leu Ala Leu Glu Lys Gln Met Ala
765 770 775AAT CTT TTT TTT GAT TAT AGA CCC TAC CCC AAA CTA GAC AAA TCG GAT 2402Asn Leu Phe Phe Asp Tyr Arg Pro Tyr Pro Lys Leu Asp Lys Ser Asp
780 785 790AAA GTA GTA GGA CTA GAA CAT TTT AAC CGC TAT GTC CTA ACA TCT TAT 2450Lys Val Val Gly Leu Glu His Phe Asn Arg Tyr Val Leu Thr Ser Tyr795 800 805 810AAA GAT TTA CAA GAT GAA AAC GAA CGC TAC GCT AAC GCT CTT GAA TGG 2498Lys Asp Leu Gln Asp Glu Asn Glu Arg Tyr Ala Asn Ala Leu Glu Trp
815 820 825CGC TTT GAA TTC CCT GAA GTT TTA GAT GAT GAG GGG GAT TTT TCA GGC 2546Arg Phe Glu Phe Pro Glu Val Leu Asp Asp Glu Gly Asp Phe Ser Gly
830 835 840TTT GAT TGC ATC ATT GGG AAT CCA CCT TAT ATC CGC CAA GAA CAC ATC 2594Phe Asp Cys Ile Ile Gly Asn Pro Pro Tyr Ile Arg Gln Glu His Ile
845 850 855AAA GAC TTA AAG CCT TTA TTA GAA AAG CAA TAC CAA GAT TTC TAT AAC 2642Lys Asp Leu Lys Pro Leu Leu Glu Lys Gln Tyr Gln Asp Phe Tyr Asn
860 865 870AGC ACC GCT GAC ATT TAC ACC TAC TTT TTT GCC CTG GCT TTC CAC CTT 2690Ser Thr Ala Asp Ile Tyr Thr Tyr Phe Phe Ala Leu Ala Phe His Leu875 880 885 890TTA AAA GAA AAG GGG TTT AGC GCT TTC ATC ACT TCT AAC AAA TAT ACG 2738Leu Lys Glu Lys Gly Phe Ser Ala Phe Ile Thr Ser Asn Lys Tyr Thr
895 900 905CGA GCC AAA TAC GGC GCT AAA TTG AGG GAA TGG CTG CTC AAA AAA ACC 2786Arg Ala Lys Tyr Gly Ala Lys Leu Arg Glu Trp LeuLeu Lys Lys Thr
910 915 920ACC ATC GTC AGC TAC ATG GAA CTA AAC GCC TTA AAA GTC TTT GAG AGC 2834Thr Ile Val Ser Tyr Met Glu Leu Asn Ala Leu Lys Val Phe Glu Ser
925 930 935GCT GCA GTG GAT ACC AGC ATC ATT CAT TTC ATC AAA CAA ACG CCC TCT 2882Ala Ala Val Asp Thr Ser Ile Ile His Phe Ile Lys Gln Thr Pro Ser
940 945 950AAA GAG AGC GAA TTT AAA TAT TAC GAA CCC ACC CCA AAC GAT AAA GAC 2930Lys Glu Ser Glu Phe Lys Tyr Tyr Glu Pro Thr Pro Asn Asp Lys Asp955 960 965 970GAT TTG AAA AGC ACC CCA CAC CTT TTG ATG AAA CAA AAC GTG CTT TCA 2978Asp Leu Lys Ser Thr Pro His Leu Leu Met Lys Gln Asn Val Leu Ser
975 980 985ACA GAA AGC TTT ATT TTT GCC AAC GCC ACG CTT TTA GAT TTG AGG GAC 3026Thr Glu Ser Phe Ile Phe Ala Asn Ala Thr Leu Leu Asp Leu Arg Asp
990 995 1000AAA ATA GAG AGT GTT GGC ACC CCG CTT AAA GAC TGG GAC ATT CAA ATC 3074Lys Ile Glu Ser Val Gly Thr Pro Leu Lys Asp Trp Asp Ile Gln Ile
1005 1010 1015AAT TAT GGG ATA AAA ACC GGC GCG AAC GAA GCC TTT ATC ATT CCC ACT 3122Asn Tyr Gly Ile Lys Thr Gly Ala Asn Glu Ala Phe Ile Ile Pro Thr 1020 1025 1030GAA AAA AGA GAA GAG ATC TTA AAC GCT TGC AAG ACG CAA GAA GAA AGG 3170Glu Lys Arg Glu Glu Ile Leu Asn Ala Cys Lys Thr Gln Glu Glu Arg1035 1040 1045 1050GAG CGC ACA GAG AGG CTT ATT AAG CCT ATT TTA AGA GGG AAA GAC ATT 3218Glu Arg Thr Glu Arg Leu Ile Lys Pro Ile Leu Arg Gly Lys Asp Ile
1055 1060 1065AAAAGG TAT TCT TAT GAG TGG GCG CAT TTG TGG GTT ATC AAC ACC CAT 3266Lys Arg Tyr Ser Tyr Glu Trp Ala His Leu Trp Val Ile Asn Thr His
1070 1075 1080AAC GGC TAC ACT TCT TCT CTC AAA TCC AAA ATC CCT CCC ATT GAT ATA 3314Asn Gly Tyr Thr Ser Ser Leu Lys Ser Lys Ile Pro Pro Ile Asp Ile
1085 1090 1095GAA AAA TAC CCC GCA ATT AAA GCG CAT TTA GAC GCT CAT TAC GAC ACT 3362Glu Lys Tyr Pro Ala Ile Lys Ala His Leu Asp Ala His Tyr Asp Thr 1100 1105 1110ATT GCA ACA CGA TGC GAT CAA GGA GAC ACC CCC TAT CAC TTA AGG AAT 3410Ile Ala Thr Arg Cys Asp Gln Gly Asp Thr Pro Tyr His Leu Arg Asn1115 1120 1125 1130TGC GCG TAT TTA GAG GAT TTT GAA AAA GAG AAA ATT GTG TGG GCA AGT 3458Cys Ala Tyr Leu Glu Asp Phe Glu Lys Glu Lys Ile Val Trp Ala Ser
1135 1140 1145GTG GGA TTT GTT GAA TAT TGT ATG ATC CCA GGA TTA TTG ATA CTT GAT 3506Val Gly Phe Val Glu Tyr Cys Met Ile Pro Gly Leu Leu Ile Leu Asp
1150 1155 1160ACA AAT TAT TTT TTT GAA GTC AGT AAA TTT GGC AAT ACA AAA AAC TAT 3554Thr Asn Tyr Phe Phe Glu Val Ser Lys Phe Gly Asn Thr Lys Asn Tyr
1165 1170 1175TTG CTT GGA CTT TTA AAT TCA AAA TTG CTA ACT TTT TGG TTA AAA GCT 3602Leu Leu Gly Leu Leu Asn Ser Lys Leu Leu Thr Phe Trp Leu Lys Ala 1180 1185 1190AAA AAT ACA CCA TTA GGC GAT ATG GGA GCT TAT AGA AAT TAT AAG TAT 3650Lys Asn Thr Pro Leu Gly Asp Met Gly Ala Tyr Arg Asn Tyr Lys Tyr1195 1200 1205 1210AAT ATT ATG GAG TTA CCG ATG GTA AAA ATA ACG GCA AAA AAT AAA AAA 3698Asn Ile Met Glu Leu Pro Met Val Lys Ile Thr Ala Lys Asn Lys Lys
1215 1220 1225ATC GCC GAT AAA ATC ATC GCT TTA GTG GAT AAA ATC CTA CAA GCA AAA 3746Ile Ala Asp Lys Ile Ile Ala Leu Val Asp Lys Ile Leu Gln Ala Lys
1230 1235 1240GAA AAA GAC CCT AAA GCC AAC ACC CAA AAG TTA GAA AAA GAA ATT GAC 3794Glu Lys Asp Pro Lys Ala Asn Thr Gln Lys Leu Glu Lys Glu Ile Asp
1245 1250 1255GCC TTA GTC TAT CAG CTC TAC CAC CTC ACC GAT GAA GAA ATT AAG ATC 3842Ala Leu Val Tyr Gln Leu Tyr His Leu Thr Asp Glu Glu Ile Lys Ile
1260 1265 1270 ATT GAA GAG GGG CAG TGAATGGAAA AGTTATTTGA AAAGATATTG CATGAAATGA G 3898 Ile Glu Glu Gly Gln1275 1 ATCAA 3903
(2) Sequence 1122 data:
(i) sequence characteristics:
(A) length: 1279 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1122: met Asp Tyr Lys Lys Leu Asp Leu Pro Asn Thr Asn Tyr Pro Asn Gln 151015 Glu Gln Leu Lys Ala Phe Glu Thr Ala Phe Asp Ala Phe Leu Glu Thr
20 25 30Asn Gln Gln Glu Asn Glu Asn His Gln Asn Asp Ala Phe Asn Asp Leu
35 40 45Leu Lys Gly Val Phe Lys Tyr Lys Val Lys Pro Thr Lys Lys Ile Asp
50 55 60Ser Thr Ile Leu Asn Glu Asn Asn Glu ValGlu Val Ile Ile Glu Phe65 70 75 80Lys Ala Leu Lys Asn Pro Asn Glu Phe Ile Lys Lys Gly Asp Leu Asn
85 90 95Val Lys Ala Phe His Glu Ser Leu Leu Ser Tyr Leu Thr Glu Arg Lys
100 105 110Glu Gly Asn Asn Asn Leu Lys His Leu Ile Leu Ala Thr Ile Lys Glu
115 120 125Leu Tyr Ile Ile Asp Ala Asn Glu Phe Glu Val Phe Asn Lys Asp Lys
130 135 140Glu Ile Glu Asn Ala Phe Lys Asn Cys His Asp Arg Lys Gly Asn Asp145 150 155 160Thr Arg Thr Lys Ala Phe Tyr Asp Ala Cys Gln Lys Arg Leu Asn Glu
165 170 175Phe Asp Arg Ser Leu Lys Tyr His Tyr Ile Pro Leu Lys Lys Glu Asn
180 185 190Leu Ala Leu Ile Tyr Gln Ala Leu Ser Pro Asn Phe Leu Leu Lys Ile
195 200 205Pro Lys Tyr Ser Asp Ala Asn Thr Leu Asn Lys Asp Phe Tyr Glu Glu
210 215 220Leu Leu Tyr Ile Leu Gly Leu Glu Glu Gln Asn Asp Lys Gly Lys Ile225 230 235 240Leu Ile Lys Pro Ser Arg Thr Gln Asn Ser Leu Ser Asp Ala Leu Lys
245 250 255Lys Glu Tyr Lys Asn Leu Asp Asp Glu Glu Val Met Ala Leu Leu Ile
260 265 270Ala Trp Asn Asn Arg Ile Leu Phe Leu Arg Leu Leu Glu Ser Leu Leu
275 280 285Ile Ser Phe Lys His Phe Glu Asn Pro Phe Leu Thr Thr Glu Asn Phe
290 295 300Glu Asn Phe Asn Asp Leu Asn Thr Leu Phe Phe Glu Val Leu Ala Lys305 310 315 320Lys Asn Ser Glu Arg Leu Pro Glu Ile Lys Glu Asp Lys Ile Leu Glu
325 330 335Lys Ile Pro Tyr Leu Asn Ser Ser Leu Phe Asp Lys Thr Pro Leu Glu
340 345 350Leu Lys Gly His Glu Ile Lys Leu Leu Asp Asn Lys Lys Leu Glu Ile
355 360 365Tyr Lys Asn Ser Val Leu Lys Lys His Lys Asp Tyr Gln Lys Glu Lys
370 375 380Pro Leu Pro Leu Leu Lys Tyr Leu Phe Lys Phe Leu Arg Leu Tyr Lys385 390 395 400Phe Thr Thr Thr Pro Lys Asp Ile Lys Asp Asn Thr Asp Thr Ser Glu
405 410 415Ser Arg Leu Ile Asn Pro Ser Val Leu Gly Leu Val Phe Glu Lys Leu
420 425 430Asn Gly Tyr Lys Glu Gly Ser Phe Tyr Thr Pro Ser Phe Ile Thr Ser
435 440 445Tyr Met Cys Lys Glu Ser Ile Thr Pro Ile Val Leu Asp Lys Phe Asn
450 455 460Ala Ile Tyr Gln Trp Asp Cys Glu Asn Leu Lys Ala Leu Arg Gly Glu465 470 475 480Ile Asp Arg Asn Phe Ser Asn Glu Lys Ala Lys Glu Tyr Leu Asn Thr
485 490 495Leu Leu Thr Leu Arg Ile Cys Asp Pro Ala Val Gly Ser Gly His Phe
500 505 510Leu Val Ser Ala Leu Asn Glu Met Val Arg Val AlaTyr Glu Leu Gly
515 520 525Leu Ile Ala Ser Leu Tyr Arg Tyr Asp Leu Lys Leu Glu Asn Asp Glu
530 535 540Ile Ile Ile His His Thr Pro Thr G1y Glu Ile Phe Asn Tyr Ile Lys545 550 555 560Pro Asp Ser Glu Asn Asp Pro His His His Ile Gln Lys Glu Leu Phe
565 570 575Asn Leu Lys Lys Ser Ile Ile Glu Asn Cys Leu Phe Gly Val Asp Ile
580 585 590Asn Pro Asn Ser Cys Glu Ile Thr Lys Leu Arg Leu Trp Ile Glu Leu
595 600 605Leu Lys Tyr Ser Tyr Tyr Ile Phe Glu Lys Gly Lys Asn Thr Asn Ala
610 615 620Leu Glu Thr Leu Pro Asn Ile Asp Ile Asn Ile Lys Cys Ala Asn Ser625 630 635 640Leu Ile Ser Arg Phe Ala Leu Lys Asp Lys Ala Leu Leu Lys Ser Glu
645 650 655Lys Asn Lys Asn Leu Glu Tyr Ser Ile Ala Glu Tyr Lys Glu Leu Val
660 665 670Lys Ile Tyr Lys Asp Pro Lys Ile Leu Glu Thr Leu Thr His Pro Ile
675 680 685Lys Asp Ser Asn Ala Val Arg Lys Tyr Ala Lys Glu Arg Leu Tyr Gln
690 695 700Glu Leu Lys Gln Asn Pro Asn Lys Asp Phe Lys Lys Ala Leu Asn Asp705 710 715 720Arg Ile Glu Lys Ile Lys Lys Ala Phe Lys Leu Thr Leu Asn Pro Pro
725 730 735Pro Lys Glu Leu Lys Phe Lys Lys Phe Leu LysGlu His Leu Glu Leu
740 745 750Tyr Gly Lys Ser Ile Leu Glu Glu Ala Asn Tyr Asn Gly Leu Glu Leu
755 760 765Glu Ala Leu Ala Leu Glu Lys Gln Met Ala Asn Leu Phe Phe Asp Tyr
770 775 780Arg Pro Tyr Pro Lys Leu Asp Lys Ser Asp Lys Val Val Gly Leu Glu785 790 795 800His Phe Asn Arg Tyr Val Leu Thr Ser Tyr Lys Asp Leu Gln Asp Glu
805 810 815Asn Glu Arg Tyr Ala Asn Ala Leu Glu Trp Arg Phe Glu Phe Pro Glu
820 825 830Val Leu Asp Asp Glu Gly Asp Phe Ser Gly Phe Asp Cys Ile Ile Gly
835 840 845Asn Pro Pro Tyr Ile Arg Gln Glu His Ile Lys Asp Leu Lys Pro Leu
850 855 860Leu Glu Lys Gln Tyr Gln Asp Phe Tyr Asn Ser Thr Ala Asp Ile Tyr865 870 875 880Thr Tyr Phe Phe Ala Leu Ala Phe His Leu Leu Lys Glu Lys Gly Phe
885 890 895Ser Ala Phe Ile Thr Ser Asn Lys Tyr Thr Arg Ala Lys Tyr Gly Ala
900 905 910Lys Leu Arg Glu Trp Leu Leu Lys Lys Thr Thr Ile Val Ser Tyr Met
915 920 925Glu Leu Asn Ala Leu Lys Val Phe Glu Ser Ala Ala Val Asp Thr Ser
930 935 940Ile Ile His Phe Ile Lys Gln Thr Pro Ser Lys Glu Ser Glu Phe Lys945 950 955 960Tyr Tyr Glu Pro Thr Pro Asn Asp Lys Asp AspLeu Lys Ser Thr Pro
965 970 975His Leu Leu Met Lys Gln Asn Val Leu Ser Thr Glu Ser Phe Ile Phe
980 985 990Ala Asn Ala Thr Leu Leu Asp Leu Arg Asp Lys Ile Glu Ser Val Gly
995 1000 1005Thr Pro Leu Lys Asp Trp Asp Ile Gln Ile Asn Tyr Gly Ile Lys Thr 1010 1015 1020Gly Ala Asn Glu Ala Phe Ile Ile Pro Thr Glu Lys Arg Glu Glu Ile025 1030 1035 1040Leu Asn Ala Cys Lys Thr Gln Glu Glu Arg Glu Arg Thr Glu Arg Leu
1045 1050 1055Ile Lys Pro Ile Leu Arg Gly Lys Asp Ile Lys Arg Tyr Ser Tyr Glu
1060 1065 1070Trp Ala His Leu Trp Val Ile Asn Thr His Asn Gly Tyr Thr Ser Ser
1075 1080 1085Leu Lys Ser Lys Ile Pro Pro Ile Asp Ile Glu Lys Tyr Pro Ala Ile 1090 1095 1100Lys Ala His Leu Asp Ala His Tyr Asp Thr Ile Ala Thr Arg Cys Asp105 1110 1115 1120Gln Gly Asp Thr Pro Tyr His Leu Arg Asn Cys Ala Tyr Leu Glu Asp
1125 1130 1135Phe Glu Lys Glu Lys Ile Val Trp Ala Ser Val Gly Phe Val Glu Tyr
1140 1145 1150Cys Met Ile Pro Gly Leu Leu Ile Leu Asp Thr Asn Tyr Phe Phe Glu
1155 1160 1165Val Ser Lys Phe Gly Asn Thr Lys Asn Tyr Leu Leu Gly Leu Leu Asn 1170 1175 1180Ser Lys Leu Leu Thr Phe Trp Leu Lys Ala Lys Asn Thr Pro Leu Gly185 1190 1195 1200Asp Met Gly AlaTyr Arg Asn Tyr Lys Tyr Asn Ile Met Glu Leu Pro
1205 1210 1215Met Val Lys Ile Thr Ala Lys Asn Lys Lys Ile Ala Asp Lys Ile Ile
1220 1225 1230Ala Leu Val Asp Lys Ile Leu Gln Ala Lys Glu Lys Asp Pro Lys Ala
1235 1240 1245Asn Thr Gln Lys Leu Glu Lys Glu Ile Asp Ala Leu Val Tyr Gln Leu 1250 1255 1260Tyr His Leu Thr Asp Glu Glu Ile Lys Ile Ile Glu Glu Gly Gln265 1270 1275 1
(2) Sequence 1123 data:
(i) sequence characteristics:
(A) length: 1415bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 28...1377
(D) Other information:
(xi) Description of the sequence: sequence 1123: TTTAAATCAT TTAAAAAAAG GATAGAG ATG CAA AAT AAA GAA ATT GGT GAA GAA 54
Met Gln Asn Lys Glu Ile Gly Glu Glu
1 5AAA AGC GTT AAT GAA AAA AAT GTA GAG GTT TTT AAT CGT TAT TTT CCC 102Lys Ser Val Asn Glu Lys Asn Val Glu Val Phe Asn Arg Tyr Phe Pro10 15 20 25GGT TGC TTG AGT ATA GAA AAT GAT AAC AAG CTC ACG CTG GAT ACA GGA 150Gly Cys Leu Ser Ile Glu Asn Asp Asn Lys Leu Thr Leu Asp Thr Gly
30 35 40AAA TTA AAA GCG TTA CTA GGG GAT TTT AGC GAG ATA AAA GAA GAG GGC 198Lys Leu Lys Ala Leu Leu Gly Asp Phe Ser Glu Ile Lys Glu Glu Gly
45 50 55TAT GGG TTG GAT TTT GTG GGT AAG AAA ATC GCC TTA AAC CAA GCT TTT 246Tyr Gly Leu Asp Phe Val Gly Lys Lys Ile Ala Leu Asn Gln Ala Phe
60 65 70AAG AAA AAT CAT AAG ATT TTA AAG CCC TTA AAC GAA TCC ACT AGC AAG 294Lys Lys Asn His Lys Ile Leu Lys Pro Leu Asn Glu Ser Thr Ser Lys
75 80 85CAC GTT CTC ATC AAG GGC GAT AAT TTA GAC GCT CTC AAA ATC TTA AAA 342His Val Leu Ile Lys Gly Asp Asn Leu Asp Ala Leu Lys Ile Leu Lys90 95 100 105CAA AGC TAT AGT GAA AAA ATC AAA ATG ATT TAC ATT GAC CCG CCT TAC 390Gln Ser Tyr Ser Glu Lys Ile Lys Met Ile Tyr Ile Asp Pro Pro Tyr
110 115 120AAC ACG AAA AAC GAG AAT TTT ATC TAT GGC GAT GAT TTC TCG GAA TCC 438Asn Thr Lys Asn Glu Asn Phe Ile Tyr Gly Asp Asp Phe Ser Gln Ser
125 130 135AAT GAA GAG GTT TTA AAA ACA TTG GAT TAT TCT AAA GAA AAA TTG GAT 486Asn Glu Glu Val Leu Lys Thr Leu Asp Tyr Ser Lys Glu Lys Leu Asp
140 145 150TAC ATC AAG AAC CTT TTT GGG TCA AAA TGC CAT AGC GGG TGG CTT AGT 534Tyr Ile Lys Asn Leu Phe Gly Ser Lys Cys His Ser Gly Trp Leu Ser
155 160 165TTC ATG TAT CCC AGA TTG TTG CTC GCT AAA GAT TTG CTC AAA CAA GAC 582Phe Met Tyr Pro Arg Leu Leu Leu Ala Lys Asp Leu Leu Lys Gln Asp170 175180 185GGC GTG ATT TTC ATT TCT ATT GAC GAT AAC GAA TGC GCT CAA CTC AAA 630Gly Val Ile Phe Ile Ser Ile Asp Asp Asn Glu Cys Ala Gln Leu Lys
190 195 200CTT TTA TGC GAT GAA ATT TTT GGG GAG GGG AAT TTT GTG GCG TGT TTA 678Leu Leu Cys Asp Glu Ile Phe Gly Glu Gly Asn Phe Val Ala Cys Leu
205 210 215AAA TGG AAA AAG AAA AAA CAA CCA AGT TTT TTA TCA AAA GTA GCC GTA 726Lys Trp Lys Lys Lys Lys Gln Pro Ser Phe Leu Ser Lys Val Ala Val
220 225 230ATA TTA GAA TAT ATT TTA GTA TAT GCA AAA GAT TTT AGT CTA ATT GAT 774Ile Leu Glu Tyr Ile Leu Val Tyr Ala Lys Asp Phe Ser Leu Ile Asp
235 240 245AAG TTA GGT TTA GAT AAT GTA TCT GAT AGC GAT AAA CCT ATC ATT AAT 822Lys Leu Gly Leu Asp Asn Val Ser Asp Ser Asp Lys Pro Ile Ile Asn250 255 260 265ACC TCT AAT AAT TTA TCA AAA AGA TAT TTT AAA AAA GGT ATT AGG GTT 870Thr Ser Asn Asn Leu Ser Lys Arg Tyr Phe Lys Lys Gly Ile Arg Val
270 275 280AAA TCT GAT TTA AAT TTT ATA AAG AGT GGA AAG TAT CAA AAT AAG ACA 918Lys Ser Asp Leu Asn Phe Ile Lys Ser Gly Lys Tyr Gln Asn Lys Thr
285 290 295ATG ACG ATT GAA TTT ATG AAT GAT ATT TTT ATT GAA AAT GGC AGA ACT 966Met Thr Ile Glu Phe Met Asn Asp Ile Phe Ile Glu Asn Gly Arg Thr
300 305 310AAA AAT GAT TTT GAA TGT ATA GGT AAA TTT AGA ACA GGA CAA GAA AAT 1014Lys Asn Asp Phe Glu Cys Ile Gly Lys Phe Arg Thr Gly Gln Glu Asn
315 320 325ATT AAT GAA TTT ATT GAA AAA GAT TTA ATT TTT ATA ACA AAA AAT TTA 1062Ile Asn Glu Phe Ile Glu Lys Asp Leu Ile Phe Ile Thr Lys Asn Leu330 335 340 345GGG ATT AGA AGA GAT TTA TTA GAA GAA GAG CAA TCA AAT AAA AAA ACA 1110Gly Ile Arg Arg Asp Leu Leu Glu Glu Glu Gln Ser Asn Lys Lys Thr
350 355 360ATT ACA GAT TTA TTA ACA GAA TGG GGA CAA AAT CAA GAT GCT ACT AAT 1158Ile Thr Asp Leu Leu Thr Glu Trp Gly Gln Asn Gln Asp Ala Thr Asn
365 370 375GAA TTA AAT ATT TTA TTT AAT AAT TCT AGC GAT GAA AGT ATT TTT TCA 1206Glu Leu Asn Ile Leu Phe Asn Asn Ser Ser Asp Glu Ser Ile Phe Ser
380 385 390AAT CCT AAA CCT ACA AAA CTC ATC AAC CGA TTG ATT GAA TTA TCC ACC 1254Asn Pro Lys Pro Thr Lys Leu Ile Asn Arg Leu Ile Glu Leu Ser Thr
395 400 405AAC GAG GGC GAC ATC ATC TTA GAC TTT TTT GCC GGG AGC GGG ACA ACC 1302Asn Glu Gly Asp Ile Ile Leu Asp Phe Phe Ala Gly Ser Gly Thr Thr410 415 420 425GCG CAT GCG GTG TTA GAG AGT AAT AAG AGC GAT TAT CAA AAA TTA AGT 1350Ala His Ala Val Leu Glu Ser Asn Lys Ser Asp Tyr Gln Lys Leu Ser
430 435 440GAG GGG GGG GGG GGT TAT TTA ATG GTT TGAACGCCGC ATTTAAAGAA AGGCGCT 1404Glu Gly Gly Gly Gly Tyr Leu Met Val
445 450TCATTCTCGT C 1415
(2) Data for sequence 1124:
(i) sequence characteristics:
(A) length: 450 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1124: met Gln Asn Lys Glu Ile Gly Glu Glu Lys Ser Val Asn Glu Lys Asn 151015 Val Glu Val Phe Asn Arg Tyr Phe Pro Gly Cys Leu Ser Ile Glu Asn
20 25 30Asp Asn Lys Leu Thr Leu Asp Thr Gly Lys Leu Lys Ala Leu Leu Gly
35 40 45Asp Phe Ser Glu Ile Lys Glu Glu Gly Tyr Gly Leu Asp Phe Val Gly
50 55 60Lys Lys Ile Ala Leu Asn Gln Ala Phe Lys Lys Asn His Lys Ile Leu65 70 75 80Lys Pro Leu Asn Glu Ser Thr Ser Lys His Val Leu Ile Lys Gly Asp
85 90 95Asn Leu Asp Ala Leu Lys Ile Leu Lys Gln Ser Tyr Ser Glu Lys Ile
100 105 110Lys Met Ile Tyr Ile Asp Pro Pro Tyr Asn Thr Lys Asn Glu Asn Phe
115 120 125Ile Tyr Gly Asp Asp Phe Ser Gln Ser Asn Glu Glu Val Leu Lys Thr
130 135 140Leu Asp Tyr Ser Lys Glu Lys Leu Asp Tyr Ile Lys Asn Leu Phe Gly145 150 155 160Ser Lys Cys His Ser Gly Trp Leu Ser Phe Met Tyr Pro Arg Leu Leu
165 170 175Leu Ala Lys Asp Leu Leu Lys Gln Asp Gly Val Ile Phe Ile Ser Ile
180 185 190Asp Asp Asn Glu Cys Ala Gln Leu Lys Leu Leu Cys Asp Glu Ile Phe
195 200 205Gly Glu Gly Asn Phe Val Ala Cys Leu Lys Trp Lys Lys Lys Lys Gln
210 215 220Pro Ser Phe Leu Ser Lys Val Ala Val Ile Leu Glu Tyr Ile Leu Val225 230 235 240Tyr Ala Lys Asp Phe Ser Leu Ile Asp Lys Leu Gly Leu Asp Asn Val
245 250 255Ser Asp Ser Asp Lys Pro Ile Ile Asn Thr Ser Asn Asn Leu Ser Lys
260 265 270Arg Tyr Phe Lys Lys Gly Ile Arg Val Lys Ser Asp Leu Asn Phe Ile
275 280 285Lys Ser Gly Lys Tyr Gln Asn Lys Thr Met Thr Ile Glu Phe Met Asn
290 295 300Asp Ile Phe Ile Glu Asn Gly Arg Thr Lys Asn Asp Phe Glu Cys Ile305 310 315 320Gly Lys Phe Arg Thr Gly Gln Glu Asn Ile Asn Glu Phe Ile Glu Lys
325 330 335Asp Leu Ile Phe Ile Thr Lys Asn Leu Gly Ile Arg Arg Asp Leu Leu
340 345 350Glu Glu Glu Gln Ser Asn Lys Lys Thr Ile Thr Asp Leu Leu Thr Glu
355 360 365Trp Gly Gln Asn Gln Asp Ala Thr Asn Glu Leu Asn Ile Leu Phe Asn
370 375 380Asn Ser Ser Asp Glu Ser Ile Phe Ser Asn Pro Lys Pro Thr Lys Leu385 390 395 400Ile Asn Arg Leu Ile Glu Leu Ser Thr Asn Glu Gly Asp Ile Ile Leu
405 410 415Asp Phe Phe Ala Gly Ser Gly Thr Thr Ala His Ala Val Leu Glu Ser
420 425 430Asn Lys Ser Asp Tyr Gln Lys Leu Ser Glu Gly Gly Gly Gly Tyr Leu
435 440 445Met Val
450
(2) Sequence 1125 data:
(i) sequence characteristics:
(A) length: 1389bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 55...1344
(D) Other information:
(xi) Description of the sequence: sequence 1125: GAAACGAATA AAAATTTTCC TTCACAACAT TTAAATGCAT TAAAATACAT TGAA ATG 57
Met
1CTT TTT TAT ATG AAA AAT TTA GAG CGC AAA AAA TTG CAA TTT GGC GCT 105Leu Phe Tyr Met Lys Asn Leu Glu Arg Lys Lys Leu Gln Phe Gly Ala
5 10 15AAA ATC GCA TGC CCC AAT AAT AAC GAG CGC TTG AAA GCG TTT ATC GCT 153Lys Ile Ala Cys Pro Asn Asn Asn Glu Arg Leu Lys Ala Phe Ile Ala
20 25 30TCT TTA CCC TTT AAA CTC ACA CGC GAT CAA CAA AAC GCC ATT AAA GAA 201Ser Leu Pro Phe Lys Leu Thr Arg Asp Gln Gln Asn Ala Ile Lys Glu
35 40 45ATC CAA AAC GAT CTC ACT AGC TCC ATA GCG TGC AAG CGT TTG ATT ATA 249Ile Gln Asn Asp Leu Thr Ser Ser Ile Ala Cys Lys Arg Leu Ile Ile50 55 60 65GGC GAT GTG GGG TGC GGG AAA ACG ATG GTG ATT TTA GCG AGC ATG GTA 297Gly Asp Val Gly Cys Gly Lys Thr Met Val Ile Leu Ala Ser Met Val
70 75 80TTA ACT TAC CCA AAT AAA ACC CTT TTA ATG GCG CCC ACT TCC ATT CTC 345Leu Thr Tyr Pro Asn Lys Thr Leu Leu Met Ala Pro Thr Ser Tle Leu
85 90 95GCT AAA CAG CTT TAT AAC GAA GCC TTA AAA TTT TTA CCC CCT TAT TTT 393Ala Lys Gln Leu Tyr Asn Glu Ala Leu Lys Phe Leu Pro Pro Tyr Phe
100 105 110GAA GTG GAA TTG CTG CTC GGC GGG AGT TAC AAG AAG CGA TCC AAT CAT 441Glu Val Glu Leu Leu Leu Gly Gly Ser Tyr Lys Lys Arg Ser Asn His
115 120 125TTG TTT GAA ACA ATC ACG CAT GTG GTT ATC GGC ACG CAA GCG TTG TTG 489Leu Phe Glu Thr Ile Thr His Val Val lle Gly Thr Gln Ala Leu Leu130 135 140 145TTT GAT AAG CGC GAT TTG AAT GAA TTC GCT CTA GTG ATC ACT GAT GAA 537Phe Asp Lys Arg Asp Leu Asn Glu Phe Ala Leu Val Ile Thr Asp Glu
150 155 160CAG CAC CGA TTT GGC ACC AAG CAG CGC TAC CAA TTA GAA AAA ATG GCA 585Gln His Arg Phe Gly Thr Lys Gln Arg Tyr Gln Leu Glu Lys Met Ala
165 170 175AGC AGT AAG GGT AAT AAA CCC CAT TCT TTG CAA TTT TCC GCT ACC CCC 633Ser Ser Lys Gly Asn Lys Pro His Ser Leu Gln Phe Ser Ala Thr Pro
180 185 190ATT CCT CGC ACG CTC GCC CTA GCC AAA AGC GCG TTT GTG AAA ACG ACC 681Ile Pro Arg Thr Leu Ala Leu Ala Lys Ser Ala PheVal Lys Thr Thr
195 200 205ATG ATT AGA GAA ATC CCT TAT CCT AAA GAG ATT GAA ACT CTA GTC TTG 729Met Ile Arg Glu Ile Pro Tyr Pro Lys Glu Ile Glu Thr Leu Val Leu210 215 220 225CAT AAA AGA GAT TTT AAA ATA GTG ATG GAG AAA ATC AGC GAA GAA ATC 777His Lys Arg Asp Phe Lys Ile Val Met Glu Lys Ile Ser Glu Glu Ile
230 235 240GCT AAA AAC CAT CAA GTC ATT GTC GTC TAT CCG CTG GTG AAT GAG AGC 825Ala Lys Asn His Gln Val Ile Val Val Tyr Pro Leu Val Asn Glu Ser
245 250 255GAA AAA ATC CCG TAT TTA TCG CTC AGT GAG GGG GCG AGT TTT TGG CAA 873Glu Lys Ile Pro Tyr Leu Ser Leu Ser Glu Gly Ala Ser Phe Trp Gln
260 265 270AAA CGC TTT AAA AAG GTT TAT ACC ACT TCA GGG CAA GAT AAA AAT AAA 921Lys Arg Phe Lys Lys Val Tyr Thr Thr Ser Gly Gln Asp Lys Asn Lys
275 280 285GAA GAA GTG ATT GAA GAA TTT AGA GAA TCC GGG AGC ATT CTT TTA GCG 969Glu Glu Val Ile Glu Glu Phe Arg Glu Ser Gly Ser Ile Leu Leu Ala290 295 300 305ACT ACG CTC ATT GAG GTG GGC ATT TCT TTA CCA CGA TTG AGC GTG ATG 1017Thr Thr Leu Ile Glu Val Gly Ile Ser Leu Pro Arg Leu Ser Val Met
310 315 320GTG ATT TTA GCG CCC GAA AGG TTA GGC TTA GCG ACT TTA CAC CAG TTA 1065Val Ile Leu Ala Pro Glu Arg Leu Gly Leu Ala Thr Leu His Gln Leu
325 330 335AGG GGG CGC GTT TCT CGT AAC GGC TTG AAA GGC TAT TGT TTT TTA TGC 1113Arg Gly Arg Val Ser Arg Asn Gly Leu Lys Gly Tyr Cys Phe Leu Cys
340 345 350ACG ATC CAA GAA GAA AAC GAA CGA TTA GAA AAG TTT GCT GAT GAA TTG 1161Thr Ile Gln Glu Glu Asn Glu Arg Leu Glu Lys Phe Ala Asp Glu Leu
355 360 365GAC GGC TTT AAA ATC GCT GAA TTG GAT TTA GAA TAC AGA AAA AGC GGG 1209Asp Gly Phe Lys Ile Ala Glu Leu Asp Leu Glu Tyr Arg Lys Ser Gly370 375 380 385GAT TTA CTC CAG GGA GGG GAG CAG AGC GGG AAT AGT TTT GAA TAC ATT 1257Asp Leu Leu Gln Gly Gly Glu Gln Ser Gly Asn Ser Phe Glu Tyr Ile
390 395 400GAC TTA GCC AAA GAT GAA AAC ATT ATC GCT GAA GTG AAA CGG GAT TTT 1305Asp Leu Ala Lys Asp Glu Asn Ile Ile Ala Glu Val Lys Arg Asp Phe
405 410 415TTA AAG GCC GCT AGC GTT TCA CGG GGA ACA TTT GAA AAT TGAAAATTAA GG 1356Leu Lys Ala Ala Ser Val Ser Arg Gly Thr Phe Glu Asn
420 425 430CAGAATTGGG TAATTTAAAT CATTTAAAAA AAG 1389
(2) Sequence 1126 material:
(i) sequence characteristics:
(A) length: 430 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1126: met Leu Phe Tyr Met Lys Asn Leu Glu Arg Lys Lys Leu Gln Phe Gly 151015 Ala Lys Ile Ala Cys Pro Asn Asn Asn Glu Arg Leu Lys Ala Phe Ile
20 25 30Ala Ser Leu Pro Phe Lys Leu Thr Arg Asp Gln Gln Asn Ala Ile Lys
35 40 45Glu Ile Gln Asn Asp Leu Thr Ser Ser Ile Ala Cys Lys Arg Leu Ile
50 55 60Ile Gly Asp Val Gly Cys Gly Lys Thr Met Val Ile Leu Ala Ser Met65 70 75 80Val Leu Thr Tyr Pro Asn Lys Thr Leu Leu Met Ala Pro Thr Ser Ile
85 90 95Leu Ala Lys Gln Leu Tyr Asn Glu Ala Leu Lys Phe Leu Pro Pro Tyr
100 105 110Phe Glu Val Glu Leu Leu Leu Gly Gly Ser Tyr Lys Lys Arg Ser Asn
115 120 125His Leu Phe Glu Thr Ile Thr His Val Val Ile Gly Thr Gln Ala Leu
130 135 140Leu Phe Asp Lys Arg Asp Leu Asn Glu Phe Ala Leu Val Ile Thr Asp145 150 155 160Glu Gln His Arg Phe Gly Thr Lys Gln Arg Tyr Gln Leu Glu Lys Met
165 170 175Ala Ser Ser Lys Gly Asn Lys Pro His Ser Leu Gln Phe Ser Ala Thr
180 185 190Pro Ile Pro Arg Thr Leu Ala Leu Ala Lys Ser Ala Phe Val Lys Thr
195 200 205Thr Met Ile Arg Glu Ile Pro Tyr Pro Lys Glu Ile Glu Thr Leu Val
210 215 220Leu His Lys Arg Asp Phe Lys Ile Val Met Glu Lys Ile Ser Glu Glu225 230 235 240Ile Ala Lys Asn His Gln Val Ile Val Val Tyr Pro Leu Val Asn Glu
245 250 255Ser Glu Lys Ile Pro Tyr Leu Ser Leu Ser Glu Gly Ala Ser Phe Trp
260 265 270Gln Lys Arg Phe Lys Lys Val Tyr Thr Thr Ser Gly Gln Asp Lys Asn
275 280 285Lys Glu Glu Val Ile Glu Glu Phe Arg Glu Ser Gly Ser Ile Leu Leu
290 295 300Ala Thr Thr Leu Ile Glu Val Gly Ile Ser Leu Pro Arg Leu Ser Val305 310 315 320Met Val Ile Leu Ala Pro Glu Arg Leu Gly Leu Ala Thr Leu His Gln
325 330 335Leu Arg Gly Arg Val Ser Arg Asn Gly Leu Lys Gly Tyr Cys Phe Leu
340 345 350Cys Thr Ile Gln Glu Glu Asn Glu Arg Leu Glu Lys Phe Ala Asp Glu
355 360 365Leu Asp Gly Phe Lys Ile Ala Glu Leu Asp Leu Glu Tyr Arg Lys Ser
370 375 380Gly Asp Leu Leu Gln Gly Gly Glu Gln Ser Gly Asn Ser Phe Glu Tyr385 390 395 400Ile Asp Leu Ala Lys Asp Glu Asn Ile Ile Ala Glu Val Lys Arg Asp
405 410 415Phe Leu Lys Ala Ala Ser Val Ser Arg Gly Thr Phe Glu Asn
420 425 430
(2) Sequence 1127 data:
(i) sequence characteristics:
(A) length: 1463 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 47...1417
(D) Other information:
(xi) Description of the sequence: sequence 1127: TGTTATTCCT TTTTCATTCA CCACTTATTC ACGCTATAAT AACGCC ATG GAT ACC 55
Met Asp Thr
1AAC AAC AAT ATT GAA AAA GAA ATC TTG GCG CTA GTC AAA CAA AAT CCT 103Asn Asn Asn Ile Glu Lys Glu Ile Leu Ala Leu Val Lys Gln Asn Pro
5 10 15AAA GTT AGT CTC ATA GAG TAT GAA AAT TAC TTT AGC CAA CTC AAA TAC 151Lys Val Ser Leu Ile Glu Tyr Glu Asn Tyr Phe Ser Gln Leu Lys Tyr20 25 30 35AAC CCT AAC GCA AGC AAG AGC GAT ATT GCC TTT TTT TAT GCC CCC AAC 199Asn Pro Asn Ala Ser Lys Ser Asp Ile Ala Phe Phe Tyr Ala Pro Asn
40 45 50CAA GTC TTA TGC ACC ACG ATT ACA GCT AAA TAC GGC GCG TTG CTT AAA 247Gln Val Leu Cys Thr Thr Ile Thr Ala Lys Tyr Gly Ala Leu Leu Lys
55 60 65GAA ATT TTA AGC CAG AAT AAA GTC GGC ATG CAT TTA GCC CAC AGC GTG 295Glu Ile Leu Ser Gln Asn Lys Val Gly Met His Leu Ala His Ser Val
70 75 80GAT GTG CGT ATT GAA GTA GCG CCT AAA ATC CAA ATT AAC GCC CAA TCT 343Asp Val Arg Ile Glu Val Ala Pro Lys Ile Gln Ile Asn Ala Gln Ser
85 90 95AAT ATC AAT TAC AAA GCC ATA AAA ACG AGC GTC AAA GAC TCT TAC ACT 391Asn Ile Asn Tyr Lys Ala Ile Lys Thr Ser Val Lys Asp Ser Tyr Thr100 105 110 115TTT GAA AAT TTT GTC GTA GGC TCA TGC AAT AAC ACC GTT TAT GAA ATC 439Phe Glu Asn Phe Val Val Gly Ser Cys Asn Asn Thr Val Tyr Glu Ile
120 125 130GCT AAA AAA GTC GCC CAA AGC GAT ACC CCC CCT TAT AAC CCG GTG CTT 487Ala Lys Lys Val Ala Gln Ser Asp Thr Pro Pro Tyr Asn Pro Val Leu
135 140 145TTT TAT GGC GGC ACA GGG TTA GGC AAA ACG CAC ATT TTA AAC GCT ATC 535Phe Tyr Gly Gly Thr Gly Leu Gly Lys Thr His Ile Leu Asn Ala Ile
150 155 160GGC AAC CAT GCC CTA GAA AAG CAT AAA AAA GTC GTG TTA GTC ACT TCA 583Gly Asn His Ala Leu Glu Lys His Lys Lys Val Val Leu Val Thr Ser
165 170 175GAA GAC TTT TTG ACA GAC TTT TTA AAG CAT TTA GAC AAC AAA ACC ATG 631Glu Asp Phe Leu Thr Asp Phe Leu Lys His Leu Asp Asn Lys Thr Met180 185 190 195GAT TCT TTT AAA GCA AAA TAC CGC CAT TGC GAC TTT TTC TTG TTA GAT 679Asp Ser Phe Lys Ala Lys Tyr Arg His Cys Asp Phe Phe Leu Leu Asp
200 205 210GAC GCT CAA TTT TTG CAA GGA AAA CCC AAG CTA GAA GAA GAA TTT TTC 727Asp Ala Gln Phe Leu Gln Gly Lys Pro Lys Leu Glu Glu Glu Phe Phe
215 220 225CAC ACC TTT AAC GAA TTG CAC GCC AAC AGC AAA CAA ATC GTA TTG ATT 775His Thr Phe Asn Glu Leu His Ala Asn Ser Lys Gln Ile Val Leu Ile
230 235 240TCA GAC CGA TCG CCT AAA AAC ATC GCC GGC TTA GAA GAT CGC TTA AAA 823Ser Asp Arg Ser Pro Lys Asn Ile Ala Gly Leu Glu Asp Arg Leu Lys
245 250 255TCG CGC TTT GAA TGG GGG ATA ACC GCT AAA GTC ATG CCC CCT GAT TTA 871SerArg Phe Glu Trp Gly Ile Thr Ala Lys Val Met Pro Pro Asp Leu260 265 270 275GAA ACC AAA CTT TCC ATT GTC AAA CAA AAA TGC CAG CTC AAT CAA ATC 919Glu Thr Lys Leu Ser Ile Val Lys Gln Lys Cys Gln Leu Asn Gln Ile
280 285 290ACT TTG CCT GAA GAG GTG ATG GAA TAC ATC GCC CAA CAC ATC AGC GAC 967Thr Leu Pro Glu Glu Val Met Glu Tyr Ile Ala Gln His Ile Ser Asp
295 300 305AAT ATC CGC CAA ATG GAA GGC GCG ATC ATT AAA ATC AGC GTG AAC GCG 1015Asn Ile Arg Gln Met Glu Gly Ala Ile Ile Lys Ile Ser Val Asn Ala
310 315 320AAC TTG ATG AAC GCT TCC ATT GAT TTG AAC CTC GCT AAA ACC GTT TTA 1063Ash Leu Met Asn Ala Ser Ile Asp Leu Asn Leu Ala Lys Thr Val Leu
325 330 335GAA GAT TTG CAA AAA GAT CAT GCT GAA GGT TCA AGC TTG GAA AAT ATC 1111Glu Asp Leu Gln Lys Asp His Ala Glu Gly Ser Ser Leu Glu Asn Ile340 345 350 355CTA CTC GCT GTC GCG CAA AGC CTG AAT CTC AAA TCC AGC GAA ATC AAA 1159Leu Leu Ala Val Ala Gln Ser Leu Asn Leu Lys Ser Ser Glu Ile Lys
360 365 370GTC TCT TCG CGC CAA AAA AAT GTC GCT TTG GCG AGG AAA TTA GTC GTG 1207Val Ser Ser Arg Gln Lys Asn Val Ala Leu Ala Arg Lys Leu Val Val
375 380 385TAT TTC GCC AGG CTT TAT ACC CCT AAC CCC ACG CTC TCG CTC GCT CAA 1255Tyr Phe Ala Arg Leu Tyr Thr Pro Asn Pro Thr Leu Ser Leu Ala Gln
390 395 400TTT TTG GAT TTA AAG GAT CAT TCA AGC ATT TCT AAA ATG TAT TCT GGC 1303Phe Leu Asp Leu Lys Asp His Ser Ser Ile Ser Lys Met Tyr Ser Gly
405 410 415GTT AAA AAA ATG CTT GAA GAA GAA AAA AGC CCT TTT GTC TTA AGC CTT 1351Val Lys Lys Met Leu Glu Glu Glu Lys Ser Pro Phe Val Leu Ser Leu420 425 430 435AGA GAA GAA ATC AAA AAC CGC TTG AAC GAA TTG AAC GAC AAA AAA ACC 1399Arg Glu Glu Ile Lys Asn Arg Leu Asn Glu Leu Asn Asp Lys Lys Thr
440 445 450GCT TTC AAT TCA AGT GAA TGAAAAAAGG CTTATGAAAA AGCGTTTCAT TCACTTCT 1455Ala Phe Asn Ser Ser Glu
455TTTCAAAT 1463
(2) Sequence 1128 data:
(i) sequence characteristics:
(A) length: 457 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1128: met Asp Thr Asn Asn Asn Ile Glu Lys Glu Ile Leu Ala Leu Val Lys 151015 Gln Asn Pro Lys Val Ser Leu Ile Glu Tyr Glu Asn Tyr Phe Ser Gln
20 25 30Leu Lys Tyr Asn Pro Asn Ala Ser Lys Ser Asp Ile Ala Phe Phe Tyr
35 40 45Ala Pro Asn Gln Val Leu Cys Thr Thr Ile Thr Ala Lys Tyr Gly Ala
50 55 60Leu Leu Lys Glu Ile Leu Ser Gln Asn Lys Val Gly Met His Leu Ala65 70 75 80His Ser Val Asp Val Arg Ile Glu Val Ala Pro Lys Ile Gln Ile Asn
85 90 95Ala Gln Ser Asn Ile Asn Tyr Lys Ala Ile Lys Thr Ser Val Lys Asp
100 105 110Ser Tyr Thr Phe Glu Asn Phe Val Val Gly Ser Cys Asn Asn Thr Val
115 120 125Tyr Glu Ile Ala Lys Lys Val Ala Gln Ser Asp Thr Pro Pro Tyr Asn
130 135 140Pro Val Leu Phe Tyr Gly Gly Thr Gly Leu Gly Lys Thr His Ile Leu145 150 155 160Asn Ala Ile Gly Asn His Ala Leu Glu Lys His Lys Lys Val Val Leu
165 170 175Val Thr Ser Glu Asp Phe Leu Thr Asp Phe Leu Lys His Leu Asp Asn
180 185 190Lys Thr Met Asp Ser Phe Lys Ala Lys Tyr Arg His Cys Asp Phe Phe
195 200 205Leu Leu Asp Asp Ala Gln Phe Leu Gln Gly Lys Pro Lys Leu Glu Glu
210 215 220Glu Phe Phe His Thr Phe Asn Glu Leu His Ala Asn Ser Lys Gln Ile225 230 235 240Val Leu Ile Ser Asp Arg Ser Pro Lys Asn Ile Ala Gly Leu Glu Asp
245 250 255Arg Leu Lys Ser Arg Phe Glu Trp Gly Ile Thr Ala Lys Val Met Pro
260 265 270Pro Asp Leu Glu Thr Lys Leu Ser Ile Val Lys Gln Lys Cys Gln Leu
275 280 285Asn Gln Ile Thr Leu Pro Glu Glu Val Met Glu Tyr Ile Ala Gln His
290 295 300Ile Ser Asp Asn Ile Arg Gln Met Glu Gly Ala Ile Ile Lys Ile Ser305 310 315 320Val Asn Ala Asn Leu Met Asn Ala Ser Ile Asp Leu Asn Leu Ala Lys
325 330 335Thr Val Leu Glu Asp Leu Gln Lys Asp His Ala Glu Gly Ser Ser Leu
340 345 350Glu Asn Ile Leu Leu Ala Val Ala Gln Ser Leu Asn Leu Lys Ser Ser
355 360 365Glu Ile Lys Val Ser Ser Arg Gln Lys Asn Val Ala Leu Ala Arg Lys
370 375 380Leu Val Val Tyr Phe Ala Arg Leu Tyr Thr Pro Asn Pro Thr Leu Ser385 390 395 400Leu Ala Gln Phe Leu Asp Leu Lys Asp His Ser Ser Ile Ser Lys Met
405 410 415Tyr Ser Gly Val Lys Lys Met Leu Glu Glu Glu Lys Ser Pro Phe Val
420 425 430Leu Ser Leu Arg Glu Glu Ile Lys Asn Arg Leu Asn Glu Leu Asn Asp
435 440 445Lys Lys Thr Ala Phe Asn Ser Ser Glu
450 455
(2) Sequence 1129 data:
(i) sequence characteristics:
(A) length: 1324 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...1260
(D) Other information:
(xi) Description of the sequence: sequence 1129: TGGCTAAAGC GTAAGGAGAG TTTA ATG GCA GAG ATA AAA AAA GCG AAA AAT 51
Met Ala Glu Ile Lys Lys Ala Lys Asn
1 5TTA GGC GAA TGG CTG GAC ATG CGT CTT GGC ACT AAC AAG CTT GTT AAA 99Leu Gly Glu Trp Leu Asp Met Arg Leu Gly Thr Asn Lys Leu Val Lys10 15 20 25GTG CTA ATG ACA GAA TAT TGG ATC CCT AAA AAC ATC AAT TTT TTA TGG 147Val Leu Met Thr Glu Tyr Trp Ile Pro Lys Asn Ile Asn Phe Leu Trp
30 35 40GCG ATG GGG GTG ATT TTA TTA ACC CTT TTT GGC GTG CTT GTG GTC TCA 195Ala Met Gly Val Ile Leu Leu Thr Leu Phe Gly Val Leu Val Val Ser
45 50 55GGG ATT TTC TTG CTC ATG TAT TAC AAG CCT GAT GCG AAA ATG GCG TTT 243Gly Ile Phe Leu Leu Met Tyr Tyr Lys Pro Asp Ala Lys Met Ala Phe
60 65 70GAT AGC GTG AAT TTC ACC ATC ATG CAA GAA GTG GCT TAT GGC TGG CTT 291Asp Ser Val Asn Phe Thr Ile Met Gln Glu Val Ala Tyr Gly Trp Leu
75 80 85TGG CGC CAC ATG CAT GCC ACG GCA GCG AGC ATG ATT TTT GTC ATC ATT 339Trp Arg His Met His Ala Thr Ala Ala Ser Met Ile Phe Val Ile Ile90 95 100 105TAT ATC CAC ATG TTT GTT GGC ATC TAT TAT GGC TCT TAC AAA AAG GGT 387Tyr Ile His Met Phe Val Gly Ile Tyr Tyr Gly Ser Tyr Lys Lys Gly
110 115 120CGT GAG ATG ATT TGG ATT AGC GGG ATG ATT TTG TTT GTG GTC TTT AGC 435Arg Glu Met Ile Trp Ile Ser Gly Met Ile Leu Phe Val Val Phe Ser
125 130135GCG GAA GCC TTT AGC GGG TAT ATG CTG CCT TGG GGG CAG ATG AGT TAT 483Ala Glu Ala Phe Ser Gly Tyr Met Leu Pro Trp Gly Gln Met Ser Tyr
140 145 150TGG GCC GCA GCG GTT ATC ACG AAT TTA TTT GGA GGC ATT CCT TTC ATT 531Trp Ala Ala Ala Val Ile Thr Asn Leu Phe Gly Gly Ile Pro Phe Ile
155 160 165GGG GCT GAT GTG GTG GAG TGG ATT AGA GGC AAT TAT GTT GTG GCG GAT 579Gly Ala Asp Val Val Glu Trp Ile Arg Gly Asn Tyr Val Val Ala Asp170 175 180 185TCC ACT TTA ACG CGC TTT TTC ATG CTC CAT GTG TTT TTA CTG CCC ATT 627Ser Thr Leu Thr Arg Phe Phe Met Leu His Val Phe Leu Leu Pro Ile
190 195 200GCG ATC ATT CTA CTT GTT GGG GTG CAT TTT TAT TCT TTA CGC ATC CCG 675Ala Ile Ile Leu Leu Val Gly Val His Phe Tyr Ser Leu Arg Ile Pro
205 210 215CAT GTC AAT AAC CAA GAA GGC GAA GAG ATT GAC TTT GAA TTA GAA GAG 723His Val Asn Asn Gln Glu Gly Glu Glu Ile Asp Phe Glu Leu Glu Glu
220 225 230AAG AAA TTC ATT GAA GGC AAG AAA AAA GAA TCC AAA GTC ATT CCT TTT 771Lys Lys Phe Ile Glu Gly Lys Lys Lys Glu Ser Lys Val Ile Pro Phe
235 240 245TGG CCG GTG TTC TTG TCT AAA GAT ATT TTT GTG GTT TGC GCG TTC ATG 819Trp Pro Val Phe Leu Ser Lys Asp Ile Phe Val Val Cys Ala Phe Met250 255 260 265GTC TTT TTC TTT TAC TTG GTG TGT TAC CAC TAT GAT TTT GCG ATG GAT 867Val Phe Phe Phe Tyr Leu Val Cys Tyr His Tyr Asp Phe Ala Met Asp
270 275 280CCT ATC AAC TTT GAA AGG GCT AAC AGC CTT AAA ACG CCG CCT CAC ATT 915Pro IleAsn Phe Glu Arg Ala Asn Ser Leu Lys Thr Pro Pro His Ile
285 290 295TAC CCT GAA TGG TAT TTC TTA TGG AGC TAT GAA GTC TTA AGA GGC TTT 963Tyr Pro Glu Trp Tyr Phe Leu Trp Ser Tyr Glu Val Leu Arg Gly Phe
300 305 310TTC TTT AGC GCT GAT TTA GGG CTA ATG GCC TTT GGC GTG GCG CAA GTG 1011Phe Phe Ser Ala Asp Leu Gly Leu Met Ala Phe Gly Val Ala Gln Val
315 320 325ATT TTC TTT TTG CTA CCC TTC TTG GAT CGA AGT CCA GTG GTC GCT CCT 1059Ile Phe Phe Leu Leu Pro Phe Leu Asp Arg Ser Pro Val Val Ala Pro330 335 340 345GCG CAC AAA CGG CCG GCG TTT ATG GTG TGG TTT TGG CTT GTA ATC ATT 1107Ala His Lys Arg Pro Ala Phe Met Val Trp Phe Trp Leu Val Ile Ile
350 355 360GAT ATG ATT GTT TTA ACG ATC TAT GGT AAA TTG CCT CCG CTT GGG ATT 1155Asp Met Ile Val Leu Thr Ile Tyr Gly Lys Leu Pro Pro Leu Gly Ile
365 370 375GGT AAA TAC ATT GGC TTA GCG GGT TCA ATC ACT TTT TTG GCC CTT TTC 1203Gly Lys Tyr Ile Gly Leu Ala Gly Ser Ile Thr Phe Leu Ala Leu Phe
380 385 390TTT GTG GTA TTG CCC ATC ATC ACT ATC GCT GAG AGC AAG AAA CAA GGG 1251Phe Val Val Leu Pro Ile Ile Thr Ile Ala Glu Ser Lys Lys Gln Gly
395 400 405GGT GTT AGA TGAAAGAGTT TAAGATTCTA ATCATCCTCA TTGTGGTGGT AGGCGTGAT 1309Gly Val Arg410TTATTATGGG GTTGA 1324
(2) Sequence 1130 data:
(i) sequence characteristics:
(A) length: 412 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1130: met Ala Glu Ile Lys Lys Ala Lys Asn Leu Gly Glu Trp Leu Asp Met 151015 Arg Leu Gly Thr Asn Lys Leu Val Lys Val Leu Met Thr Glu Tyr Trp
20 25 30Ile Pro Lys Asn Ile Asn Phe Leu Trp Ala Met Gly Val Ile Leu Leu
35 40 45Thr Leu Phe Gly Val Leu Val Val Ser Gly Ile Phe Leu Leu Met Tyr
50 55 60Tyr Lys Pro Asp Ala Lys Met Ala Phe Asp Ser Val Asn Phe Thr Ile65 70 75 80Met Gln Glu Val Ala Tyr Gly Trp Leu Trp Arg His Met His Ala Thr
85 90 95Ala Ala Ser Met Ile Phe Val Ile Ile Tyr Ile His Met Phe Val Gly
100 105 110Ile Tyr Tyr Gly Ser Tyr Lys Lys Gly Arg Glu Met Ile Trp Ile Ser
115 120 125Gly Met Ile Leu Phe Val Val Phe Ser Ala Glu Ala Phe Ser Gly Tyr
130 135 140Met Leu Pro Trp Gly Gln Met Ser Tyr Trp Ala Ala Ala Val Ile Thr145 150 155 160Asn Leu Phe Gly Gly Ile Pro Phe Ile Gly Ala Asp Val Val Glu Trp
165 170 175Ile Arg Gly Asn Tyr Val Val Ala Asp Ser Thr Leu Thr Arg Phe Phe
180 185 190Met Leu His Val Phe Leu Leu Pro Ile Ala Ile Ile Leu Leu Val Gly
195 200 205Val His Phe Tyr Ser Leu Arg Ile Pro His Val Asn Asn Gln Glu Gly
210 215 220Glu Glu Ile Asp Phe Glu Leu Glu Glu Lys Lys Phe Ile Glu Gly Lys225 230 235 240Lys Lys Glu Ser Lys Val Ile Pro Phe Trp Pro Val Phe Leu Ser Lys
245 250 255Asp Ile Phe Val Val Cys Ala Phe Met Val Phe Phe Phe Tyr Leu Val
260 265 270Cys Tyr His Tyr Asp Phe Ala Met Asp Pro Ile Asn Phe Glu Arg Ala
275 280 285Asn Ser Leu Lys Thr Pro Pro His Ile Tyr Pro Glu Trp Tyr Phe Leu
290 295 300Trp Ser Tyr Glu Val Leu Arg Gly Phe Phe Phe Ser Ala Asp Leu Gly305 310 315 320Leu Met Ala Phe Gly Val Ala Gln Val Ile Phe Phe Leu Leu Pro Phe
325 330 335Leu Asp Arg Ser Pro Val Val Ala Pro Ala His Lys Arg Pro Ala Phe
340 345 350Met Val Trp Phe Trp Leu Val Ile Ile Asp Met Ile Val Leu Thr Ile
355 360 365Tyr Gly Lys Leu Pro Pro Leu Gly Ile Gly Lys Tyr Ile Gly Leu Ala
370 375 380Gly Ser Ile Thr Phe Leu Ala Leu Phe Phe Val Val Leu Pro Ile Ile385 390 395 400Thr Ile Ala Glu Ser Lys Lys Gln Gly Gly Val Arg
405 410
(2) Data of sequence 1131:
(i) sequence characteristics:
(A) length: 462 bp by
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 22...429
(D) Other information:
(xi) Description of the sequence: sequence 1131: CAATAAAGAA AGGAGCATCA G ATG GCA ATC TTT GAT AAC AAT AAT AAA TCG 51
Met Ala Ile Phe Asp Asn Asn Asn Lys Ser
1 5 10GCT AAT GCA AAA ACA GGA CCA GCG ACT ATC ATC GCT CAA GGC ACA AAA 99Ala Asn Ala Lys Thr Gly Pro Ala Thr Ile Ile Ala Gln Gly Thr Lys
15 20 25ATA AAG GGG GAG CTT CAT TTA GAT TAC CAT TTG CAC GTA GAT GGC GAA 147Ile Lys Gly Glu Leu His Leu Asp Tyr His Leu His Val Asp Gly Glu
30 35 40TTA GAA GGG GTG GTG CAT TCT AAA AGC ACG GTG GTG ATC GGG CAA ACC 195Leu Glu Gly Val Val His Ser Lys Ser Thr Val Val Ile Gly Gln Thr
45 50 55GGC TCG GTA GTG GGT GAG ATT TTT ACT AAT AAA TTA GTG GTC AGT GGC 243Gly Ser Val Val Gly Glu Ile Phe Thr Asn Lys Leu Val Val Ser Gly
60 65 70AAG TTC ACT GGC ACG GTG GAG GCG GAA GTG GTA GAA ATC ATG CCT TTA 291Lys Phe Thr Gly Thr Val Glu Ala Glu Val Val Glu Ile Met Pro Leu7580 85 90GGG CAC CTT GAT GGC AAA ATC TCT AGC CAA GAG CTT GTG GTG GAA AGA 339Gly His Leu Asp Gly Lys Ile Ser Ser Gln Glu Leu Val Val Glu Arg
95 100 105AAG GGG ATT TTG ATT GGG GAA ACT CGC CCT AAG AAT ATT CAA GGG GGG 387Lys Gly Ile Leu Ile Gly Glu Thr Arg Pro Lys Ash Ile Gln Gly Gly
110 115 120GCG TTG TTA ATC AAT GAG CAA GAA AAG AAA ATT GAA AAT AAA TAGGGAATG 438Ala Leu Leu Ile Asn Glu Gln Glu Lys Lys Ile Glu Asn Lys
125 130 135ATCCAATCCA GCCTTTATAG AGCC 462
(2) Sequence 1132 data:
(i) sequence characteristics:
(A) length: 136 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1132: met Ala Ile Phe Asp Asn Asn Asn Lys Ser Ala Asn Ala Lys Thr Gly 151015 Pro Ala Thr Ile Ile Ala Gln Gly Thr Lys Ile Lys Gly Glu Leu His
20 25 30Leu Asp Tyr His Leu His Val Asp Gly Glu Leu Glu Gly Val Val His
35 40 45Ser Lys Ser Thr Val Val Ile Gly Gln Thr Gly Ser Val Val Gly Glu
50 55 60Ile Phe Thr Asn Lys Leu Val Val Ser Gly Lys Phe Thr Gly Thr Val65 70 75 80Glu Ala Glu Val Val Glu Ile Met Pro Leu Gly His Leu Asp Gly Lys
85 90 95Ile Ser Ser Gln Glu Leu Val Val Glu Arg Lys Gly Ile Leu Ile Gly
100 105 110Glu Thr Arg Pro Lys Asn Ile Gln Gly Gly Ala Leu Leu Ile Asn Glu
115 120 125Gln Glu Lys Lys Ile Glu Asn Lys
130 135
(2) Data in sequence 1133:
(i) sequence characteristics:
(A) length: 391 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 13...348
(D) Other information:
(xi) Description of the sequence: sequence 1133: TAAGGAGTTT CT ATG GAT TGG GGT CGG GTC GTT CAT GTG CTG TTC AGC CTT 51
Met Asp Trp Gly Arg Val Val His Val Leu Phe Ser Leu
1 5 10ATT TCT TTA ACC ACC ATT GCA GGG TTT TTG TAT GAG CCT AAT ACG GTG 99Ile Ser Leu Thr Thr Ile Ala Gly Phe Leu Tyr Glu Pro Asn Thr Val
15 20 25GTG TTG TTT GTA GCG TTA GCT TTA AAC CTT ATT TCT GTT ACG CTT AAA 147Val Leu Phe Val Ala Leu Ala Leu Asn Leu Ile Ser Val Thr Leu Lys30 35 40 45ATT GGG GTG ATC AAG CGT TTC GCT TCA GAG CTA TTG GCC AGCTCT TTA 195Ile Gly Val Ile Lys Arg Phe Ala Ser Glu Leu Leu Ala Ser Ser Leu
50 55 60GCC ACC GTA TTG CAT CTC ATA CCG GCA TTT GTG TTT TTA CAG ATT TTA 243Ala Thr Val Leu His Leu Ile Pro Ala Phe Val Phe Leu Gln Ile Leu
65 70 75AAT AAT TTG GTT ACC GCT TAC ATG CTC ATG ATC GGG GCG TTG ATT AGC 291Asn Asn Leu Val Thr Ala Tyr Met Leu Met Ile Gly Ala Leu Ile Ser
80 85 90AAC GCT TTC AGT CTC ATC TTT TTG TTG ATT GAA AGC GTT GTA ACG AGC 339Asn Ala Phe Ser Leu Ile Phe Leu Leu Ile Glu Ser Val Val Thr Ser
95 100 105GAA ACG GAT TAAGGGGTAG TGATGGATTT TATCAATATA GAAAAAAAT GGC 391Glu Thr Asp110
(2) Data in sequence 1134:
(i) sequence characteristics:
(A) length: 112 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1134: met Asp Trp Gly Arg Val Val His Val Leu Phe Ser Leu Ile Ser Leu 151015 Thr Thr Ile Ala Gly Phe Leu Tyr Glu Pro Asn Thr Val Val Leu Phe
20 25 30Val Ala Leu Ala Leu Asn Leu Ile Ser Val Thr Leu Lys Ile Gly Val
35 40 45Ile Lys Arg Phe Ala Ser Glu Leu Leu Ala Ser Ser Leu Ala Thr Val
50 55 60Leu His Leu Ile Pro Ala Phe Val Phe LeuGln Ile Leu Asn Asn Leu65 70 75 80Val Thr Ala Tyr Met Leu Met Ile Gly Ala Leu Ile Ser Asn Ala Phe
85 90 95Ser Leu Ile Phe Leu Leu Ile Glu Ser Val Val Thr Ser Glu Thr Asp
100 105 110
(2) Data of sequence 1135:
(i) sequence characteristics:
(A) length: 1035 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...993
(D) Other information:
(xi) Description of the sequence: sequence 1135: GAATAAAAGA GCTTAGGAGG TTTT ATG GAA TTA TTC AAA CGA ACT AGA ATC 51
Met Glu Leu Phe Lys Arg Thr Arg Ile
1 5TTA AGC TTC ATG CGT TAT TCC AAT TAT GGG GTG ATC GTT TCA GCA ATT 99Leu Ser Phe Met Arg Tyr Ser Asn Tyr Gly Val Ile Val Ser Ala Ile10 15 20 25TTA GCG CTT CTA GCG TTG GGG CTT TTG TTT TTC AAA GGG TTT TCT TTA 147Leu Ala Leu Leu Ala Leu Gly Leu Leu Phe Phe Lys Gly Phe Ser Leu
30 35 40GGG ATT GAT TTT GCG GGG GGG AGT TTG GTG CAA GTG CGC TAC ACT CAA 195Gly Ile Asp Phe Ala Gly Gly Ser Leu Val Gln Val Arg Tyr Thr Gln
45 50 55AAC GCC CCC ATT AAA GAA GTG CGC GAT CTG TTT GAA AAA GAA GCT CGC 243Asn Ala Pro Ile Lys Glu Val Arg Asp Leu Phe Glu Lys Glu Ala Arg
60 65 70TTC AAA GGC GTG CAA GTG AGC GAA TTT GGC TCT AAA GAA GAA ATT TTA 291Phe Lys Gly Val Gln Val Ser Glu Phe Gly Ser Lys Glu Glu Ile Leu
75 80 85ATC AAA TTC CCT TTT GTA GAA ACG GCT GAA AAT GAA GAT CTG AAC GCT 339Ile Lys Phe Pro Phe Val Glu Thr Ala Glu Asn Glu Asp Leu Asn Ala90 95 100 105ATC GTG GCC AAC ATT CTA AAA CCC AGC GGC GAT TTT GAA ATC CGT AAA 387Ile Val Ala Asn Ile Leu Lys Pro Ser Gly Asp Phe Glu Ile Arg Lys
110 115 120TTT GAC ACC GTG GGC CCT AGA GTG GGG AGC GAA TTG AAA GAG AAA GGC 435Phe Asp Thr Val Gly Pro Arg Val Gly Ser Glu Leu Lys Glu Lys Gly
125 130 135ATT TTG TCG CTG ATT TTA GCA TTA ATA GCG ATC ATG GTT TAT GTG AGT 483Ile Leu Ser Leu Ile Leu Ala Leu Ile Ala Ile Met Val Tyr Val Ser
140 145 150TTC CGC TAT GAA TGG CGT TTT GCT TTA GCG AGC GTC ATT GCG CTT GTG 531Phe Arg Tyr Glu Trp Arg Phe Ala Leu Ala Ser Val Ile Ala Leu Val
155 160 165CAT GAT GTG ATT TTA GTG GCA AGC TCG GTG ATT GTT TTT AAG ATT GAT 579His Asp Val Ile Leu Val Ala Ser Ser Val Ile Val Phe Lys Ile Asp170 175 180 185ATG AAT TTG GAA GTG ATT GCG GCC TTG CTC ACC TTG ATT GGG TAT TCC 627Met Asn Leu Glu Val Ile Ala Ala Leu Leu Thr Leu Ile Gly Tyr Ser
190 195 200ATT AAT GAT ACG ATC ATT ATT TTT GAC AGG ATCAGA GAA GAG ATG CTY 675Ile Asn Asp Thr Ile Ile Ile Phe Asp Arg Ile Arg Glu Glu Met Xaa
205 210 215TCT CAA AAA ACC AAA AAC GCC ACT CAA GCC ATT GAT GAA GCC ATT TCT 723Ser Gln Lys Thr Lys Asn Ala Thr Gln Ala Ile Asp Glu Ala Ile Ser
220 225 230AGC ACG CTC ACG CGC ACG CTT TTA ACT TCT TTA ACC GTG TTT TTT GTG 771Ser Thr Leu Thr Arg Thr Leu Leu Thr Ser Leu Thr Val Phe Phe Val
235 240 245GTG TTG ATT TTG TGC GTG TTT GGG AGT AAG ATC ATC ATT GGC TTT TCA 819Val Leu Ile Leu Cys Val Phe Gly Ser Lys Ile Ile Ile Gly Phe Ser250 255 260 265TTG CCC ATG TTA ATA GGC ACG ATT GTA GGG ACT TAT AGC TCT ATT TTC 867Leu Pro Met Leu Ile Gly Thr Ile Val Gly Thr Tyr Ser Ser Ile Phe
270 275 280ATC GCC CCT AAA GTG GCG TTA TTG TTA GGC TTT GAT ATG GAT AAA TAT 915Ile Ala Pro Lys Val Ala Leu Leu Leu Gly Phe Asp Met Asp Lys Tyr
285 290 295TAT GAG AAT GAG ACT AGA AAA ATT AAA AAA GCT CAA GAG AAA GAA AAA 963Tyr Glu Asn Glu Thr Arg Lys Ile Lys Lys Ala Gln Glu Lys Glu Lys
300 305 310ATG CGC CGT TTG TAT GAG AGC GGT CAA GTT TAAGGAGTTT CTATGGATTG GGG 1016Met Arg Arg Leu Tyr Glu Ser Gly Gln Val
315 320TCGGGTCGTT CATGTGCTG 1035
(2) Data of sequence 1136:
(i) sequence characteristics:
(A) length: 323 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1136: met Glu Leu Phe Lys Arg Thr Arg Ile Leu Ser Phe Met Arg Tyr Ser 151015 Asn Tyr Gly Val Ile Val Ser Ala Ile Leu Ala Leu Leu Ala Leu Gly
20 25 30Leu Leu Phe Phe Lys Gly Phe Ser Leu Gly Ile Asp Phe Ala Gly Gly
35 40 45Ser Leu Val Gln Val Arg Tyr Thr Gln Asn Ala Pro Ile Lys Glu Val
50 55 60Arg Asp Leu Phe Glu Lys Glu Ala Arg Phe Lys Gly Val Gln Val Ser65 70 75 80Glu Phe Gly Ser Lys Glu Glu Ile Leu Ile Lys Phe Pro Phe Val Glu
85 90 95Thr Ala Glu Asn Glu Asp Leu Asn Ala Ile Val Ala Asn Ile Leu Lys
100 105 110Pro Ser Gly Asp Phe Glu Ile Arg Lys Phe Asp Thr Val Gly Pro Arg
115 120 125Val Gly Ser Glu Leu Lys Glu Lys Gly Ile Leu Ser Leu Ile Leu Ala
130 135 140Leu Ile Ala Ile Met Val Tyr Val Ser Phe Arg Tyr Glu Trp Arg Phe145 150 155 160Ala Leu Ala Ser Val Ile Ala Leu Val His Asp Val Ile Leu Val Ala
165 170 175Ser Ser Val Ile Val Phe Lys Ile Asp Met Asn Leu Glu Val Ile Ala
180 185 190Ala Leu Leu Thr Leu Ile Gly Tyr Ser Ile Asn Asp Thr Ile Ile Ile
195 200 205Phe Asp Arg Ile Arg Glu Glu Met Xaa Ser Gln Lys Thr Lys Asn Ala
210 215 220Thr Gln Ala Ile Asp Glu Ala Ile Ser Ser Thr Leu Thr Arg Thr Leu225 230 235 240Leu Thr Ser Leu Thr Val Phe Phe Val Val Leu Ile Leu Cys Val Phe
245 250 255Gly Ser Lys Ile Ile Ile Gly Phe Ser Leu Pro Met Leu Ile Gly Thr
260 265 270Ile Val Gly Thr Tyr Ser Ser Ile Phe Ile Ala Pro Lys Val Ala Leu
275 280 285Leu Leu Gly Phe Asp Met Asp Lys Tyr Tyr Glu Asn Glu Thr Arg Lys
290 295 300Ile Lys Lys Ala Gln Glu Lys Glu Lys Met Arg Arg Leu Tyr Glu Ser305 310 315 320Gly Gln Val
(2) Data of sequence 1137:
(i) sequence characteristics:
(A) length: 670 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 56...634
(D) Other information:
(xi) Description of the sequence: sequence 1137: TAGCTATTTC TTTAAAGCCG CTCTTTTGTC TAGCGCAAAT AAATACAAAG CCCCT ATG 58
Met
1ATC CCA GAA ATC AAA GAT CCG AGT AAA ATC GCA ATT TTT GCC ACT TCC 106Ile Pro Glu Ile Lys Asp Pro Ser Lys Ile Ala Ile Phe Ala Thr Ser
5 10 15ATA GCG TCT TTA TGC TCG CTC GTG AAG GCC AGA TTA GAA ATA AAC ATA 154Ile Ala Ser Leu Cys Ser Leu Val Lys Ala Arg Leu Glu Ile Asn Ile
20 25 30GAC ATG GTA AAG CCA ATC CCT GCT AAA AGC CCA GCC CCT AAA ATA TGC 202Asp Met Val Lys Pro Ile Pro Ala Lys Ser Pro Ala Pro Lys Ile Cys
35 40 45CAC CAG CTG ATG CCT TTA GGG CGT GCG GTG ATT TTA AGC TTT TCG CTT 250His Gln Leu Met Pro Leu Gly Arg Ala Val Ile Leu Ser Phe Ser Leu50 55 60 65ATA AAA GTG ATT AAG AAA ATC CCT AAA GGT TTG CCC AAG CAA AGC CCT 298Ile Lys Val Ile Lys Lys Ile Pro Lys Gly Leu Pro Lys Gln Ser Pro
70 75 80AAA ATA ACC CCT AAA AGC ACC TTA TCC ACT TCT AAA TTG ATG CTA GAA 346Lys Ile Thr Pro Lys Ser Thr Leu Ser Thr Ser Lys Leu Met Leu Glu
85 90 95TCA ACG CTC ACC CCA GCG TTT GCA AAC GCG AAT AAG GGC ATG ATG AAA 394Ser Thr Leu Thr Pro Ala Phe Ala Asn Ala Asn Lys Gly Met Met Lys
100 105 110TAC CCG CTA ATG GGG GCT AGA AAA TGC TCC AAT CTT TCT AAG GGG CTT 442Tyr Pro Leu Met Gly Ala Arg Lys Cys Ser Asn Leu Ser Lys Gly Leu
115 120 125TGT AAG GCG CTC GCT TTT TCT TCA ATA GAA TGC AAG ATT TCT TGC TGC 490Cys Lys Ala Leu Ala Phe Ser Ser Ile Glu Cys Lys Ile Ser Cys Cys130 135 140145TCT TTA CTC AAA AGC GCT CCT GAA CTC GTT TCT GCG TAT CGT TTG CCT 538Ser Leu Leu Lys Ser Ala Pro Glu Leu Val Ser Ala Tyr Arg Leu Pro
150 155 160AGT TCC AAA AGC TCT ACA TTT TTA GAA TCT TTA GGG ATC TTC ACC GGT 586Ser Ser Lys Ser Ser Thr Phe Leu Glu Ser Leu Gly Ile Phe Thr Gly
165 170 175ATC ATA AAA GCT AGA ATC ACT GCA GCA ATC GTC GCA TGG ATA CCG CTT T 635Ile Ile Lys Ala Arg Ile Thr Ala Ala Ile Val Ala Trp Ile Pro Leu
180 185 190GATGCACGCA AAACCAAAGC AACACCCCTA AAAGC 670
(2) Data of sequence 1138:
(i) sequence characteristics:
(A) length: 193 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1138: met Ile Pro Glu Ile Lys Asp Pro Ser Lys Ile Ala Ile Phe Ala Thr 151015 Ser Ile Ala Ser Leu Cys Ser Leu Val Lys Ala Arg Leu Glu Ile Asn
20 25 30Ile Asp Met Val Lys Pro Ile Pro Ala Lys Ser Pro Ala Pro Lys Ile
35 40 45Cys His Gln Leu Met Pro Leu Gly Arg Ala Val Ile Leu Ser Phe Ser
50 55 60Leu Ile Lys Val Ile Lys Lys Ile Pro Lys Gly Leu Pro Lys Gln Ser65 70 75 80Pro Lys Ile Thr Pro Lys Ser Thr Leu Ser Thr Ser Lys Leu Met Leu
85 90 95Glu Ser Thr Leu Thr Pro Ala Phe Ala Asn Ala Asn Lys Gly Met Met
100 105 110Lys Tyr Pro Leu Met Gly Ala Arg Lys Cys Ser Asn Leu Ser Lys Gly
115 120 125Leu Cys Lys Ala Leu Ala Phe Ser Ser Ile Glu Cys Lys Ile Ser Cys
130 135 140Cys Ser Leu Leu Lys Ser Ala Pro Glu Leu Val Ser Ala Tyr Arg Leu145 150 155 160Pro Ser Ser Lys Ser Ser Thr Phe Leu Glu Ser Leu GIy Ile Phe Thr
165 170 175Gly Ile Ile Lys Ala Arg Ile Thr Ala Ala Ile Val Ala Trp Ile Pro
180 185 190Leu
(2) Data in sequence 1139:
(i) sequence characteristics:
(A) length: 1427 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...1365
(D) Other information:
(xi) Description of the sequence: sequence 1139: AAGACTGCTT GAAAAATT ATG GGT CTG AAA TTA AAA ATT TTA AGG TTG TCT 51
Met Gly Leu Lys Leu Lys Ile Leu Arg Leu Ser
1 5 10ATG AAT CTC AAA AAA ACA GAA AAC GCGCTC AGT TTG ACG CTT AAG AAC 99Met Asn Leu Lys Lys Thr Glu Asn Ala Leu Ser Leu Thr Leu Lys Asn
15 20 25TTC ATT AAA AGC GAG TCT TTT GGA GGG ATT TTC CTC TTT TTA AAC GCT 147Phe Ile Lys Ser Glu Ser Phe Gly Gly Ile Phe Leu Phe Leu Asn Ala
30 35 40GTT TTA GCG ATG GTG GTG GCT AAT TCG TTT TTA AAA GAA AGT TAT TTT 195Val Leu Ala Met Val Val Ala Asn Ser Phe Leu Lys Glu Ser Tyr Phe
45 50 55GCA CTA TGG CAC ACC CCT TTT GGG TTT CAA ATA GGG GAT TTT TTC ATC 243Ala Leu Trp His Thr Pro Phe Gly Phe Gln Ile Gly Asp Phe Phe Ile60 65 70 75GGC TTT AGT TTG CAC AAC TGG ATT GAT GAT GTC TTA ATG GCG TTA TTC 291Gly Phe Ser Leu His Asn Trp Ile Asp Asp Val Leu Met Ala Leu Phe
80 85 90TTT TTA ATG ATA GGC TTA GAA ATC AAA CGA GAA TTG TTG TTT GGG GAA 339Phe Leu Met Ile Gly Leu Glu Ile Lys Arg Glu Leu Leu Phe Gly Glu
95 100 105TTA TCC AGT TTC AAA AAA GCT TCT TTT CCT GTG ATT GCG GCC ATA GGG 387Leu Ser Ser Phe Lys Lys Ala Ser Phe Pro Val Ile Ala Ala Ile Gly
110 115 120GGC ATG ATA GCC CCA GGA TTG ATT TAT TTT TTT CTT AAC GCT AAC ACG 435Gly Met Ile Ala Pro Gly Leu Ile Tyr Phe Phe Leu Asn Ala Asn Thr
125 130 135CCT TCC CAG CAT GGT TTT GGG ATC CCT ATG GCG ACG GAT ATT GCG TTC 483Pro Ser Gln His Gly Phe Gly Ile Pro Met Ala Thr Asp Ile Ala Phe140 145 150 155GCT TTA GGC GTG ATC ATG CTT TTA GGC AAG AGG GTG CCA ACC GCT TTA 531Ala Leu Gly Val Ile Met Leu Leu Gly Lys Arg Val Pro Thr Ala Leu
160 165 170AAG GTT TTT TTA ATC ACT CTA GCG GTG GCT GAT GAC TTG GGG GCT ATT 579Lys Val Phe Leu Ile Thr Leu Ala Val Ala Asp Asp Leu Gly Ala Ile
175 180 185GTG GTG ATC GCG CTC TTT TAT ACC ACG AAT TTA AAA TTC GCA TGG CTT 627Val Val Ile Ala Leu Phe Tyr Thr Thr Asn Leu Lys Phe Ala Trp Leu
190 195 200TTA GGG GCT TTA GGG GTG GTT CTT GTT TTA GCC GTA TTA AAC CGC CTG 675Leu Gly Ala Leu Gly Val Val Leu Val Leu Ala Val Leu Asn Arg Leu
205 210 215AAT ATG CGC TCG CTC ATC CCT TAC TTG CTT TTA GCG GTG TTG CTT TGG 723Asn Met Arg Ser Leu Ile Pro Tyr Leu Leu Leu Gly Val Leu Leu Trp220 225 230 235TTT TGC GTG CAT CAA AGC GGT ATC CAT GCG ACG ATT GCT GCA GTG ATT 771Phe Cys Val His Gln Ser Gly Ile His Ala Thr Ile Ala Ala Val Ile
240 245 250CTA GCT TTT ATG ATA CCG GTG AAG ATC CCT AAA GAT TCT AAA AAT GTA 819Leu Ala Phe Met Ile Pro Val Lys Ile Pro Lys Asp Ser Lys Asn Val
255 260 265GAG CTT TTG GAA CTA GGC AAA CGA TAC GCA GAA ACG AGT TCA GGA GCG 867Glu Leu Leu Glu Leu Gly Lys Arg Tyr Ala Glu Thr Ser Ser Gly Ala
270 275 280CTT TTG AGT AAA GAG CAG CAA GAA ATC TTG CAT TCT ATT GAA GAA AAA 915Leu Leu Ser Lys Glu Gln Gln Glu Ile Leu His Ser Ile Glu Glu Lys
285 290 295GCG AGC GCC TTA CAA AGC CCC TTA GAA AGA TTG GAG CAT TTT CTA GCC 963Ala Ser Ala Leu Gln Ser Pro Leu Glu Arg Leu Glu His Phe Leu Ala300 305 310315CCC ATT AGC GGG TAT TTC ATC ATG CCC TTA TTC GCG TTT GCA AAC GCT 1011Pro Ile Ser Gly Tyr Phe Ile Met Pro Leu Phe Ala Phe Ala Asn Ala
320 325 330GGG GTG AGC GTT GAT TCT AGC ATC AAT TTA GAA GTG GAT AAG GTG CTT 1059Gly Val Ser Val Asp Ser Ser Ile Asn Leu Glu Val Asp Lys Val Leu
335 340 345TTA GGG GTT ATT TTA GGG CTT TGC TTG GGC AAA CCT TTA GGG ATT TTC 1107Leu Gly Val Ile Leu Gly Leu Cys Leu Gly Lys Pro Leu Gly Ile Phe
350 355 360TTA ATC ACT TTT ATA AGC GAA AAG CTT AAA ATC ACC GCA CGC CCT AAA 1155Leu Ile Thr Phe Ile Ser Glu Lys Leu Lys Ile Thr Ala Arg Pro Lys
365 370 375GGC ATC AGC TGG TGG CAT ATT TTA GGG GCT GGG CTT TTA GCA GGG ATT 1203Gly Ile Ser Trp Trp His Ile Leu Gly Ala Gly Leu Leu Ala Gly Ile380 385 390 395GGC TTT ACC ATG TCT ATG TTT ATT TCT AAT CTG GCC TTC ACG AGC GAG 1251Gly Phe Thr Met Ser Met Phe Ile Ser Asn Leu Ala Phe Thr Ser Glu
400 405 410CAT AAA GAC GCT ATG GAA GTG GCA AAA ATT GCG ATT TTA CTC GGA TCT 1299His Lys Asp Ala Met Glu Val Ala Lys Ile Ala Ile Leu Leu Gly Ser
415 420 425TTG ATT TCT GGG ATC ATA GGG GCT TTG TAT TTA TTT GCG CTA GAC AAA 1347Leu Ile Ser Gly Ile Ile Gly Ala Leu Tyr Leu Phe Ala Leu Asp Lys
430 435 440AGA GCG GCT TTA AAG AAA TAGCTAAAAA TGCTATAATT TGAGATTAAA ACATCTTT 1403Arg Ala Ala Leu Lys Lys
445TAAGGAAATT AAATGGGACA AATT 1427
(2) Sequence 1140 data:
(i) sequence characteristics:
(A) length: 449 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1140: met Gly Leu Lys Leu Lys Ile Leu Arg Leu Ser Met Asn Leu Lys Lys 151015 Thr Glu Asn Ala Leu Ser Leu Thr Leu Lys Asn Phe Ile Lys Ser Glu
20 25 30Ser Phe Gly Gly Ile Phe Leu Phe Leu Asn Ala Val Leu Ala Met Val
35 40 45Val Ala Asn Ser Phe Leu Lys Glu Ser Tyr Phe Ala Leu Trp His Thr
50 55 60Pro Phe Gly Phe Gln Ile Gly Asp Phe Phe Ile Gly Phe Ser Leu His65 70 75 80Asn Trp Ile Asp Asp Val Leu Met Ala Leu Phe Phe Leu Met Ile Gly
85 90 95Leu Glu Ile Lys Arg Glu Leu Leu Phe Gly Glu Leu Ser Ser Phe Lys
100 105 110Lys Ala Ser Phe Pro Val Ile Ala Ala Ile Gly Gly Met Ile Ala Pro
115 120 125Gly Leu Ile Tyr Phe Phe Leu Asn Ala Asn Thr Pro Ser Gln His Gly
130 135 140Phe Gly Ile Pro Met Ala Thr Asp Ile Ala Phe Ala Leu Gly Val Ile145 150 155 160Met Leu Leu Gly Lys Arg Val Pro Thr Ala Leu Lys Val Phe Leu Ile
165 170 175Thr Leu Ala Val AlaAsp Asp Leu Gly Ala Ile Val Val Ile Ala Leu
180 185 190Phe Tyr Thr Thr Asn Leu Lys Phe Ala Trp Leu Leu Gly Ala Leu Gly
195 200 205Val Val Leu Val Leu Ala Val Leu Asn Arg Leu Asn Met Arg Ser Leu
210 215 220Ile Pro Tyr Leu Leu Leu Gly Val Leu Leu Trp Phe Cys Val His Gln225 230 235 240Ser Gly Ile His Ala Thr Ile Ala Ala Val Ile Leu Ala Phe Met Ile
245 250 255Pro Val Lys Ile Pro Lys Asp Ser Lys Asn Val Glu Leu Leu Glu Leu
260 265 270Gly Lys Arg Tyr Ala Glu Thr Ser Ser Gly Ala Leu Leu Ser Lys Glu
275 280 285Gln Gln Glu Ile Leu His Ser Ile Glu Glu Lys Ala Ser Ala Leu Gln
290 295 300Ser Pro Leu Glu Arg Leu Glu His Phe Leu Ala Pro Ile Ser Gly Tyr305 310 315 320Phe Ile Met Pro Leu Phe Ala Phe Ala Asn Ala Gly Val Ser Val Asp
325 330 335Ser Ser Ile Asn Leu Glu Val Asp Lys Val Leu Leu Gly Val Ile Leu
340 345 350Gly Leu Cys Leu Gly Lys Pro Leu Gly Ile Phe Leu Ile Thr Phe Ile
355 360 365Ser Glu Lys Leu Lys Ile Thr Ala Arg Pro Lys Gly Ile Ser Trp Trp
370 375 380His Ile Leu Gly Ala Gly Leu Leu Ala Gly Ile Gly Phe Thr Met Ser385 390 395 400Met Phe Ile Ser Asn Leu Ala Phe Thr Ser Glu His Lys Asp Ala Met
405 410 415Glu Val Ala Lys Ile Ala Ile Leu Leu Gly Ser Leu Ile Ser Gly Ile
420 425 430Ile Gly Ala Leu Tyr Leu Phe Ala Leu Asp Lys Arg Ala Ala Leu Lys
435 440 445Lys
(2) Sequence 1141 data:
(i) sequence characteristics:
(A) length: 1903 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 13...1857
(D) Other information:
(xi) Description of the sequence: sequence 1141: AAGTAAGTGC TT ATG GAT AAT AGG AAT ATT GAT CCT TAC TTC AAC CCA GAG 51
Met Asp Asn Arg Asn Ile Asp Pro Tyr Phe Asn Pro Glu
1 5 10CAA TTT TTA GAA ACC CAA AAA TAC AAA GGC ACG GTT ACA GCA TTA ATC 99Gln Phe Leu Glu Thr Gln Lys Tyr Lys Gly Thr Val Thr Ala Leu Ile
15 20 25TTT TTA TTG CTT TTT TTT ATT TTT TTA ATG GTG GCT TTT AAA AAA GCT 147Phe Leu Leu Leu Phe Phe Ile Phe Leu Met Val Ala Phe Lys Lys Ala30 35 40 45TTT TTT GCC CAA GCC AAC ATG CCT AAT CTA GTG ATG AGC AAA CAA GAC 195Phe Phe Ala Gln Ala Asn Met Pro Asn Leu Val Met Ser Lys Gln Asp
50 55 60ACT GCG GCT AGG GGG ACT ATC TAT AGT CAA GAC AAC TAC AGC CTA GCC 243Thr Ala Ala Arg Gly Thr Ile Tyr Ser Gln Asp Asn Tyr Ser Leu Ala
65 70 75ACT TCA CAA ACC CTT TTC AAA CTG GGC TTT GAT ACA AGG TTT TTA AAC 291Thr Ser Gln Thr Leu Phe Lys Leu Gly Phe Asp Thr Arg Phe Leu Asn
80 85 90CCG GAT AAA GAA GAT TTT TTC ATT GAT TTC CTT TCT ATT TAT AGC AAT 339Pro Asp Lys Glu Asp Phe Phe Ile Asp Phe Leu Ser Ile Tyr Ser Asn
95 100 105ATC CCT AAA AAG TCC TTA AAA GAC GCC ATC AAT ACA AAA GGC TAT ATC 387Ile Pro Lys Lys Ser Leu Lys Asp Ala Ile Asn Thr Lys Gly Tyr Ile110 115 120 125ATT CTA GCC TAT GAT CTC ACG CCC AAT ATG GCT GCT AAT ATT AGA GAC 435Ile Leu Ala Tyr Asp Leu Thr Pro Asn Met Ala Ala Asn Ile Arg Asp
130 135 140TTA AAT AAG AAA TTT TTA GCC TTT GGG GTT TTT CAA AAT TTC AAA GAC 483Leu Asn Lys Lys Phe Leu Ala Phe Gly Val Phe Gln Asn Phe Lys Asp
145 150 155GCG CAC GAT AAG GTG TGG CAA AAG CAA GGG CTA AAC ATT GAA GTG AGC 531Ala His Asp Lys Val Trp Gln Lys Gln Gly Leu Asn Ile Glu Val Ser
160 165 170GGC GTT TCT AGG CAT TAC CCT TAT CAA AAT AGC CTA GAG CCA ATC ATT 579Gly Val Ser Arg His Tyr Pro Tyr Gln Asn Ser Leu Glu Pro Ile Ile
175 180 185GGC TAT GTG CAA AAA CAA GAA GAA GAC AAG CTC ACT TTA ACT ACC GGT 627Gly Tyr Val Gln Lys Gln Glu Glu Asp Lys Leu Thr Leu Thr Thr Gly190 195 200 205AAAAAA GGC GTT GAA AAA TCT CAA GAT CAC TTG CTT AAA GCC CAA CAA 675Lys Lys Gly Val Glu Lys Ser Gln Asp His Leu Leu Lys Ala Gln Gln
210 215 220AAT GGC ATA AGA ACA GGC AAA AGA GAC GTG AGT TTT AAC TTT ATC CAA 723Asn Gly Ile Arg Thr Gly Lys Arg Asp Val Ser Phe Asn Phe Ile Gln
225 230 235AAC CAC TCT TAT ACA GAG GTT GAA CGC CTT GAT GGC TAT GAG GTG TAT 771Asn His Ser Tyr Thr Glu Val Glu Arg Leu Asp Gly Tyr Glu Val Tyr
240 245 250TTG AGC GTT CCT TTA AAA CTC CAA AGA GAA ATT GAA ACC CTA TTG GAT 819Leu Ser Val Pro Leu Lys Leu Gin Arg Glu Ile Glu Thr Leu Leu Asp
255 260 265AAA ACT AAA GAC AAA CTC AAG GCT AAA GAA ATC CTA GTG GGT ATC ATT 867Lys Thr Lys Asp Lys Leu Lys Ala Lys Glu Ile Leu Val Gly Ile Ile270 275 280 285AAC CCT AAA AGC GGG GAA ATT TTA TCG CTA GCT TCA AGC AAG CGC TTC 915Asn Pro Lys Ser Gly Glu Ile Leu Ser Leu Ala Ser Ser Lys Arg Phe
290 295 300AAT CCT AAT GCG ATT AAA ACC AGC GAT TAT GAA AGC TTG AAT TTG AGC 963Asn Pro Asn Ala Ile Lys Thr Ser Asp Tyr Glu Ser Leu Asn Leu Ser
305 310 315GTT GCT GAA AAG GTT TTT GAG CCA GGC AGC ACG ATC AAA CCC ATT GTT 1011Val Ala Glu Lys Val Phe Glu Pro Gly Ser Thr Ile Lys Pro Ile Val
320 325 330TAT TCC TTG CTG TTA GAC AAG AAT TTG ATC AAC CCC AAA GAA CGC ATT 1059Tyr Ser Leu Leu Leu Asp Lys Asn Leu Ile Asn Pro Lys Glu Arg Ile
335 340 345GAT TTA AAC CAT GGC TAT TAC CAA TTA GGA AAA TAC ACC ATT AAA GAC 1107Asp Leu Asn His Gly Tyr Tyr Gln Leu Gly Lys Tyr Thr Ile Lys Asp350 355 360 365GAC TTT ATC CCC AGT AAA AAA GCC GTT GTG GAA GAC ATT TTG ATC CAA 1155Asp Phe Ile Pro Ser Lys Lys Ala Val Val Glu Asp Ile Leu Ile Gln
370 375 380TCT AGC AAT GTG GGC ATG ATA AAA ATC AGT AAA AAC TTA AAC CCA AAG 1203Ser Ser Asn Val Gly Met Ile Lys Ile Ser Lys Asn Leu Asn Pro Lys
385 390 395GAT TTC TAT AAT GGG CTT TTA GGC TAT GGA TTT TCT CAA AAA ACC GGC 1251Asp Phe Tyr Asn Gly Leu Leu Gly Tyr Gly Phe Ser Gln Lys Thr Gly
400 405 410ATT GAT TTA TCT CTA GAA GCC ACA GGA AAG ATC CCT CCT TTG TCC GCT 1299Ile Asp Leu Ser Leu Glu Ala Thr Gly Lys Ile Pro Pro Leu Ser Ala
415 420 425TTC AAG CGT GAA GTG TTA AAG GGG AGC GTT TCT TAT GGC TAT GGG CTG 1347Phe Lys Arg Glu Val Leu Lys Gly Ser Val Ser Tyr Gly Tyr Gly Leu430 435 440 445AAC GCG ACT TTT TTG CAG CTT TTA AGG GCT TAT GCG GTG TTT TCT AAT 1395Asn Ala Thr Phe Leu Gln Leu Leu Arg Ala Tyr Ala Val Phe Ser Asn
450 455 460GAA GGC AAA TTG ACT ACC CCC TAT TTA GTG CAA CGA GAA ACC GCC CCT 1443Glu Gly Lys Leu Thr Thr Pro Tyr Leu Val Gln Arg Glu Thr Ala Pro
465 470 475AAT GGC GAT ATT TAC ATC CCT AGC CCC AAA CCC ACC TTT CAA GTC ATT 1491Asn Gly Asp Ile Tyr Ile Pro Ser Pro Lys Pro Thr Phe Gln Val Ile
480 485 490AGC CCA AAA AGC GCT AGG AAA ATG AAA GAA ACC TTA ATC AAA GTA GTG 1539Ser Pro Lys Ser Ala Arg Lys Met Lys Glu Thr Leu Ile LysVal Val
495 500 505CGT TAT GGC ACA GGC AAA AAC GCT CAA TTT GAA GGG CTA TAC ATA GGG 1587Arg Tyr Gly Thr Gly Lys Asn Ala Gln Phe Glu Gly Leu Tyr Ile Gly510 515 520 525GGC AAA ACC GGC ACG GCT AGG GTC GCT AAA AAC GGG AGT TAT AGC GCG 1635Gly Lys Thr Gly Thr Ala Arg Val Ala Lys Asn Gly Ser Tyr Ser Ala
530 535 540CAG TCC TAC AAC AGC TCT TTT TTT GGG TTT GCT GAA GAT GAA AGG CAG 1683Gln Ser Tyr Asn Ser Ser Phe Phe Gly Phe Ala Glu Asp Glu Arg Gln
545 550 555GTT TTT ACT ATC GGC GTG GTT ATC TTA GGT TCG CAT GGC AAG GAA GAA 1731Val Phe Thr Ile Gly Val Val Ile Leu Gly Ser His Gly Lys Glu Glu
560 565 570TAT TAC GCC AGC AAG ATT GCA GCC CCC ATT TTT AAA GAA ATC ACC GAA 1779Tyr Tyr Ala Ser Lys Ile Ala Ala Pro Ile Phe Lys Glu Ile Thr Glu
575 580 585ATT TTA GTG CGT TAC AAT TAT CTA TCG CCC TCT ATT GCG ATT CAA AAC 1827Ile Leu Val Arg Tyr Asn Tyr Leu Ser Pro Ser Ile Ala Ile Gln Asn590 595 600 605GCG CTC GAG AAA AAC CGC TTT AAG ATA AAA TAAAAGGCTC TTTTCAACCC AAA 1880Ala Leu Glu Lys Asn Arg Phe Lys Ile Lys
610 615CTCCAAAAAA GGAGTCTTAA GTT 1903
(2) Sequence 1142 data:
(i) sequence characteristics:
(A) length: 615 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1142: met Asp Asn Arg Asn Ile Asp Pro Tyr Phe Asn Pro Glu Gln Phe Leu 151015 Glu Thr Gln Lys Tyr Lys Gly Thr Val Thr Ala Leu Ile Phe Leu Leu
20 25 30Leu Phe Phe Ile Phe Leu Met Val Ala Phe Lys Lys Ala Phe Phe Ala
35 40 45Gln Ala Asn Met Pro Asn Leu Val Met Ser Lys Gln Asp Thr Ala Ala
50 55 60Arg Gly Thr Ile Tyr Ser Gln Asp Asn Tyr Ser Leu Ala Thr Ser Gln65 70 75 80Thr Leu Phe Lys Leu Gly Phe Asp Thr Arg Phe Leu Asn Pro Asp Lys
85 90 95Glu Asp Phe Phe Ile Asp Phe Leu Ser Ile Tyr Ser Asn Ile Pro Lys
100 105 110Lys Ser Leu Lys Asp Ala Ile Asn Thr Lys Gly Tyr Ile Ile Leu Ala
115 120 125Tyr Asp Leu Thr Pro Asn Met Ala Ala Asn Ile Arg Asp Leu Asn Lys
130 135 140Lys Phe Leu Ala Phe Gly Val Phe Gln Asn Phe Lys Asp Ala His Asp145 150 155 160Lys Val Trp Gln Lys Gln Gly Leu Asn Ile Glu Val Ser Gly Val Ser
165 170 175Arg His Tyr Pro Tyr Gln Asn Ser Leu Glu Pro Ile Ile Gly Tyr Val
180 185 190Gln Lys Gln Glu Glu Asp Lys Leu Thr Leu Thr Thr Gly Lys Lys Gly
195 200 205Val Glu Lys Ser Gln Asp His Leu Leu Lys Ala Gln Gln Asn Gly Ile
210 215 220Arg Thr Gly Lys Arg Asp Val Ser Phe Asn Phe Ile Gln Asn His Ser225 230 235 240Tyr Thr Glu Val Glu Arg Leu Asp Gly Tyr Glu Val Tyr Leu Ser Val
245 250 255Pro Leu Lys Leu Gln Arg Glu Ile Glu Thr Leu Leu Asp Lys Thr Lys
260 265 270Asp Lys Leu Lys Ala Lys Glu Ile Leu Val Gly Ile Ile Asn Pro Lys
275 280 285Ser Gly Glu Ile Leu Ser Leu Ala Ser Ser Lys Arg Phe Asn Pro Asn
290 295 300Ala Ile Lys Thr Ser Asp Tyr Glu Ser Leu Asn Leu Ser Val Ala Glu305 310 315 320Lys Val Phe Glu Pro Gly Ser Thr Ile Lys Pro Ile Val Tyr Ser Leu
325 330 335Leu Leu Asp Lys Asn Leu Ile Asn Pro Lys Glu Arg Ile Asp Leu Asn
340 345 350His Gly Tyr Tyr Gln Leu Gly Lys Tyr Thr Ile Lys Asp Asp Phe Ile
355 360 365Pro Ser Lys Lys Ala Val Val Glu Asp Ile Leu Ile Gln Ser Ser Asn
370 375 380Val Gly Met Ile Lys Ile Ser Lys Asn Leu Asn Pro Lys Asp Phe Tyr385 390 395 400Asn Gly Leu Leu Gly Tyr Gly Phe Ser Gln Lys Thr Gly Ile Asp Leu
405 410 415Ser Leu Glu Ala Thr Gly Lys Ile Pro Pro Leu Ser Ala Phe Lys Arg
420 425 430Glu Val Leu Lys Gly Ser Val Ser Tyr Gly Tyr Gly Leu Asn Ala Thr
435 440 445Phe Leu Gln Leu Leu Arg Ala Tyr Ala Val Phe Ser Asn Glu Gly Lys
450 455 460Leu Thr Thr Pro Tyr Leu Val Gln Arg Glu Thr Ala Pro Asn Gly Asp465 470 475 480Ile Tyr Ile Pro Ser Pro Lys Pro Thr Phe Gln Val Ile Ser Pro Lys
485 490 495Ser Ala Arg Lys Met Lys Glu Thr Leu Ile Lys Val Val Arg Tyr Gly
500 505 510Thr Gly Lys Asn Ala Gln Phe Glu Gly Leu Tyr Ile Gly Gly Lys Thr
515 520 525Gly Thr Ala Arg Val Ala Lys Asn Gly Ser Tyr Ser Ala Gln Ser Tyr
530 535 540Asn Ser Ser Phe Phe Gly Phe Ala Glu Asp Glu Arg Gln Val Phe Thr545 550 555 560Ile Gly Val Val Ile Leu Gly Ser His Gly Lys Glu Glu Tyr Tyr Ala
565 570 575Ser Lys Ile Ala Ala Pro Ile Phe Lys Glu Ile Thr Glu Ile Leu Val
580 585 590Arg Tyr Asn Tyr Leu Ser Pro Ser Ile Ala Ile Gln Asn Ala Leu Glu
595 600 605Lys Asn Arg Phe Lys Ile Lys
610 615
(2) Sequence 1143 data:
(i) sequence characteristics:
(A) length: 719 bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...678
(D) Other information:
(xi) Description of the sequence: sequence 1143: TAGCCTAGTC TTTATCGC ATG CTA TTT AAT GGG CTA TGC TTA TTT GAA CAG 51
Met Leu Phe Asn Gly Leu Cys Leu Phe Glu Gln
1 5 10GCA AGT TTG TGC TTT AGA AAA GCG AGC GTT TCA ATG AAA AAG CTC AAA 99Ala Ser Leu Cys Phe Arg Lys Ala Ser Val Ser Met Lys Lys Leu Lys
15 20 25GGT CTT TTT TTG ATC CTG CTC TTA TGG GTC TAT CCT TTA AGG AGT GAG 147Gly Leu Phe Leu Ile Leu Leu Leu Trp Val Tyr Pro Leu Arg Ser Glu
30 35 40CCA ATC AAT GAG GGA GCA TAC ATT TTA GAA GAG ATT GGC GAT GTG CTT 195Pro Ile Asn Glu Gly Ala Tyr Ile Leu Glu Glu Ile Gly Asp Val Leu
45 50 55AGG TTT TTG CCT ATT TTT GTA GGC ACG GTC AGT TTG GCG ATG CGC GAT 243Arg Phe Leu Pro Ile Phe Val Gly Thr Val Ser Leu Ala Met Arg Asp60 65 70 75TAT AGA GGG TTA GGG GAA TTA GCG GTC GGC ACA TTG GTT ACT CAA GGC 291Tyr Arg Gly Leu Gly Glu Leu Ala Val Gly Thr Leu Val Thr Gln Gly
80 85 90GTG ATT TAT GGC CTT AAA GGA GCT TTT AGC AAC GCC CAT AAA GAT GGG 339Val Ile Tyr Gly Leu Lys Gly Ala Phe Ser Asn Ala His Lys Asp Gly
95 100 105GCT AGA GTG GAA TTT GCT AAA CGC CCG TGC TGT AAT TCT TGG AGA GGC 387Ala Arg Val Glu Phe Ala Lys Arg Pro Cys Cys Asn Ser Trp Arg Gly
110 115 120ATG CCA AGC GGG CAT GCT GGG GGG GTG TTT AGC GCG GCT GGG TTT GTG 435Met Pro Ser Gly His Ala Gly Gly Val Phe Ser Ala Ala Gly Phe Val
125 130 135TAT TAC CGC TAT GGG TGG AAG CCG GCT CTT CCT GTG ATC GCT CTT GCA 483Tyr Tyr Arg Tyr Gly Trp Lys Pro Ala Leu Pro Val Ile Ala Leu Ala140 145 150 155ATC CTC ACT GAC GCT AGC AGA GTG GTG GCA AGA CAA CAC ACG ATC TTG 531Ile Leu Thr Asp Ala Ser Arg Val Val Ala Arg Gln His Thr Tle Leu
160 165 170CAA GTT ACG ATC GGC AGC CTT ATC GCA TGG GGG TTT GCT TAT TTA TTC 579Gln Val Thr Ile Gly Ser Leu Ile Ala Trp Gly Phe Ala Tyr Leu Phe
175 180 185ACT TCA CGC TAC AAA CCC AAG CAA TGG ATG CTC TAT CCT GAA ATT TCT 627Thr Ser Arg Tyr Lys Pro Lys Gln Trp Met Leu Tyr Pro Glu Ile Ser
190 195 200AGC GAT TTT AAG GGC AGT AGC CGC TAT GGG GTG AGC TTT TCT TAT CAA 675Ser Asp Phe Lys Gly Ser Ser Arg Tyr Gly Val Ser Phe Ser Tyr Gln
205 210 215TGG TAAAGGGATA AAGTGCTAAA AAAATTATTA TTCATTGCAC T 719Trp220
(2) Sequence 1144 data:
(i) sequence characteristics:
(A) length: 220 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1144: met Leu Phe Asn Gly Leu Cys Leu Phe Glu Gln Ala Ser Leu Cys Phe 151015 Arg Lys Ala Ser Val Ser Met Lys Lys Leu Lys Gly Leu Phe Leu Ile
20 25 30Leu Leu Leu Trp Val Tyr Pro Leu Arg Ser Glu Pro Ile Asn Glu Gly
35 40 45Ala Tyr Ile Leu Glu Glu Ile Gly Asp Val Leu Arg Phe Leu Pro Ile
50 55 60Phe Val Gly Thr Val Ser Leu Ala Met Arg Asp Tyr Arg Gly Leu Gly65 70 75 80Glu Leu Ala Val Gly Thr Leu Val Thr Gln Gly Val Ile Tyr Gly Leu
85 90 95Lys Gly Ala Phe Ser Asn Ala His Lys Asp Gly Ala Arg Val Glu Phe
100 105 110Ala Lys Arg Pro Cys Cys Asn Ser Trp Arg Gly Met Pro Ser Gly His
115 120 125Ala Gly Gly Val Phe Ser Ala Ala Gly Phe Val Tyr Tyr Arg Tyr Gly
130 135 140Trp Lys Pro Ala Leu Pro Val Ile Ala Leu Ala Ile Leu Thr Asp Ala145 150 155 160Ser Arg Val Val Ala Arg Gln His Thr Ile Leu Gln Val Thr Ile Gly
165 170 175Ser Leu Ile Ala Trp Gly Phe Ala Tyr Leu Phe Thr Ser Arg Tyr Lys
180 185 190Pro Lys Gln Trp Met Leu Tyr Pro Glu Ile Ser Ser Asp Phe Lys Gly
195 200 205Ser Ser Arg Tyr Gly Val Ser Phe Ser Tyr Gln Trp
210 215 220
(2)Sequence 1145 data:
(i) sequence characteristics:
(A) length: 1087 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 34...1053
(D) Other information:
(xi) Description of the sequence: sequence 1145: TTCAAGCAAA AACACCACCC AAATATAAAG ATA ATG ATT TTA AGC ATT GAA AGT 54
Met Ile Leu Ser Ile Glu Ser
1 5TCT TGC GAT GAC AGC TCT TTA GCC CTT ACA AGA ATA GAG GAC GCT CAA 102Ser Cys Asp Asp Ser Ser Leu Ala Leu Thr Arg Ile Glu Asp Ala Gln
10 15 20CTC ATC GCT CAT TTT AAA ATC TCT CAA GAA AAG CAC CAT AGT TCT TAT 150Leu Ile Ala His Phe Lys Ile Ser Gln Glu Lys His His Ser Ser Tyr
25 30 35GGG GGC GTT GTG CCT GAG CTT GCA TCA CGT TTG CAT GCT GAG AAT TTG 198Gly Gly Val Val Pro Glu Leu Ala Ser Arg Leu His Ala Glu Asn Leu40 45 50 55CCG CTT TTA TTA GAA CGC ATT AAA ATA AGC TTG AAT AAG GAT TTT TCC 246Pro Leu Leu Leu Glu Arg Ile Lys Ile Ser Leu Asn Lys Asp Phe Ser
60 65 70AAA ATT AAA GCC ATC GCT ATC ACT AAT CAG CCA GGT TTG AGC GTT ACT 294Lys Ile Lys Ala Ile Ala Ile Thr Asn Gln Pro Gly Leu Ser Val Thr
75 80 85TTA ATA GAA GGT TTG ATG ATG GCA AAA GCC TTG AGC TTG TCT TTG AAT 342Leu Ile Glu Gly Leu Met Met Ala Lys Ala Leu Ser Leu Ser Leu Asn
90 95 100TTG CCC TTG ATT TTA GAA GAT CAT TTG AGA GGG CAT GTG TAT TCG CTC 390Leu Pro Leu Ile Leu Glu Asp His Leu Arg Gly His Val Tyr Ser Leu
105 110 115TTT ATC AAT GAA AAA CAA ACC TGC ATG CCT TTA AGC GTG CTC TTA GTC 438Phe Ile Asn Glu Lys Gln Thr Cys Met Pro Leu Ser Val Leu Leu Val120 125 130 135TCT GGG GGG CAT TCT TTG ATT TTA GAG GCT AGA GAT TAT GAG AAT ATT 486Ser Gly Gly His Ser Leu Ile Leu Glu Ala Arg Asp Tyr Glu Asn Ile
140 145 150AAA ATC GTT GCC ACG AGT TTA GAC GAT AGC TTT GGG GAG AGT TTT GAT 534Lys Ile Val Ala Thr Ser Leu Asp Asp Ser Phe Gly Glu Ser Phe Asp
155 160 165AAG GTT TCC AAA ATG CTT GAT TTA GGC TAT CCA GGA GGC CCT ATA GTG 582Lys Val Ser Lys Met Leu Asp Leu Gly Tyr Pro Gly Gly Pro Ile Val
170 175 180GAA AAA TTA GCC CTT GAT TAT AGG CAC CCA AAC GAG CCT TTA ATG TTC 630Glu Lys Leu Ala Leu Asp Tyr Arg His Pro Asn Glu Pro Leu Met Phe
185 190 195CCT ATC CCT TTA AAA AAC AGC CCG AAT CTG GCT TTT AGT TTT TCA GGT 678Pro Ile Pro Leu Lys Asn Ser Pro Asn Leu Ala Phe Ser Phe Ser Gly200 205 210 215TTA AAA AAT GCG GTG CGT TTG GAG GTT GAA AAA AAC GCC CCC AAC TTG 726Leu Lys Asn Ala Val Arg Leu Glu Val Glu Lys Asn Ala Pro Asn Leu
220 225230AAT GAA GCG ATC AAA CAA AAG ATT GGC TAT CAT TTT CAA AGT GCA GCG 774Asn Glu Ala Ile Lys Gln Lys Ile Gly Tyr His Phe Gln Ser Ala Ala
235 240 245ATT GAG CAT TTA ATC CAG CAG ACT AAA CGC TAT TTT AAA ATC AAA CGC 822Ile Glu His Leu Ile Gln Gln Thr Lys Arg Tyr Phe Lys Ile Lys Arg
250 255 260CCT AAA ATT TTT GGC ATT GTG GGG GGA GCG AGC CAA AAT TTG GCT TTA 870Pro Lys Ile Phe Gly Ile Val Gly Gly Ala Ser Gln Asn Leu Ala Leu
265 270 275AGA AAG GCG TTT GAA AAT TTG TGC GAT GCG TTT GAT TGC AAG CTT GTT 918Arg Lys Ala Phe Glu Asn Leu Cys Asp Ala Phe Asp Cys Lys Leu Val280 285 290 295TTA GCC CCT TTA GAA TTT TGC AGC GAC AAT GCC GCC ATG ATA GGG CGA 966Leu Ala Pro Leu Glu Phe Cys Ser Asp Asn Ala Ala Met Ile Gly Arg
300 305 310TCC AGC CTA GAA GCT TAT CAA AAA AAG CGC TTT GTC CCT TTA GAA AAG 1014Ser Ser Leu Glu Ala Tyr Gln Lys Lys Arg Phe Val Pro Leu Glu Lys
315 320 325GCT AAC ATT TCG CCA AGA ACG CTG TTA AAA AGT TTT GAG TGAATGGATA CA 1065Ala Asn Ile Ser Pro Arg Thr Leu Leu Lys Ser Phe Glu
330 335 340AAAAGAAAGC GCATGATAAA AC 1087
(2) Sequence 1146 data:
(i) sequence characteristics:
(A) length: 340 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1146: met Ile Leu Ser Ile Glu Ser Ser Cys Asp Asp Ser Ser Leu Ala Leu 151015 Thr Arg Ile Glu Asp Ala Gln Leu Ile Ala His Phe Lys Ile Ser Gln
20 25 30Glu Lys His His Ser Ser Tyr Gly Gly Val Val Pro Glu Leu Ala Ser
35 40 45Arg Leu His Ala Glu Asn Leu Pro Leu Leu Leu Glu Arg Ile Lys Ile
50 55 60Ser Leu Asn Lys Asp Phe Ser Lys Ile Lys Ala Ile Ala Ile Thr Asn65 70 75 80Gln Pro Gly Leu Ser Val Thr Leu Ile Glu GIy Leu Met Met Ala Lys
85 90 95Ala Leu Ser Leu Ser Leu Asn Leu Pro Leu Ile Leu Glu Asp His Leu
100 105 110Arg Gly His Val Tyr Ser Leu Phe Ile Asn Glu Lys Gln Thr Cys Met
115 120 125Pro Leu Ser Val Leu Leu Val Ser Gly Gly His Ser Leu Ile Leu Glu
130 135 140Ala Arg Asp Tyr Glu Asn Ile Lys Ile Val Ala Thr Ser Leu Asp Asp145 150 155 160Ser Phe Gly Glu Ser Phe Asp Lys Val Ser Lys Met Leu Asp Leu Gly
165 170 175Tyr Pro Gly Gly Pro Ile Val Glu Lys Leu Ala Leu Asp Tyr Arg His
180 185 190Pro Asn Glu Pro Leu Met Phe Pro Ile Pro Leu Lys Asn Ser Pro Asn
195 200 205Leu Ala Phe Ser Phe Ser Gly Leu Lys Asn Ala Val Arg Leu Glu Val
210 215 220Glu Lys Asn Ala Pro Asn Leu Asn Glu Ala Ile Lys Gln Lys Ile Gly225 230 235 240Tyr His Phe Gln Ser Ala Ala Ile Glu His Leu Ile Gln Gln Thr Lys
245 250 255Arg Tyr Phe Lys Ile Lys Arg Pro Lys Ile Phe Gly Ile Val Gly Gly
260 265 270Ala Ser Gln Asn Leu Ala Leu Arg Lys Ala Phe Glu Asn Leu Cys Asp
275 280 285Ala Phe Asp Cys Lys Leu Val Leu Ala Pro Leu Glu Phe Cys Ser Asp
290 295 300Asn Ala Ala Met Ile Gly Arg Ser Ser Leu Glu Ala Tyr Gln Lys Lys305 310 315 320Arg Phe Val Pro Leu Glu Lys Ala Asn Ile Ser Pro Arg Thr Leu Leu
325 330 335Lys Ser Phe G1u
340
(2) Sequence 1147 data:
(i) sequence characteristics:
(A) length: 547 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 34...498
(D) Other information: (xi) Description of the sequence: sequence 1147: TGCACTTGTT ATGATGAAGA TGGCGCACTA AGA ATG AAT GAA GAC TTG ACA AAT 54
Met Asn Glu Asp Leu Thr Asn
1 5TCA ACA GAA TAT AAA AGA TAT GGC CAT GAT TAC GCC AAA TAC CCA AGA 102Ser Thr Glu Tyr Lys Arg Tyr Gly His Asp Tyr Ala Lys Tyr Pro Arg
10 15 20AGA ATC GCT GAA GAA TTG CAA CAT TAT GGG GGC AAT AGT TTT GCG AAT 150Arg Ile Ala Glu Glu Leu Gln His Tyr Gly Gly Asn Ser Phe Ala Asn
25 30 35TTT TTT AGA GAT GAA GGG GTC TTA TAC AAA GAG ATT TTG TGC GAT GCG 198Phe Phe Arg Asp Glu Gly Val Leu Tyr Lys Glu Ile Leu Cys Asp Ala40 45 50 55TGC GAT CAT TTA AAG GTT AAT TAC AAT GAA GAA TCT GCA ACC TCT TTG 246Cys Asp His Leu Lys Val Asn Tyr Asn Glu Glu Ser Ala Thr Ser Leu
60 65 70ATT GAG CAA AAC ATG CTT TCT AAA CTC TTG AAA GAT AGT TTA GAA AAA 294Ile Glu Gln Asn Met Leu Ser Lys Leu Leu Lys Asp Ser Leu Glu Lys
75 80 85ATG AGT AGG AGA GAG ATT AAA GAA CTT TGC AAT GAA TTG GGC ATG ACA 342Met Ser Arg Arg Glu Ile Lys Glu Leu Cys Asn Glu Leu Gly Met Thr
90 95 100AAT ATT GAT AAA GTG ATT GGT GAA AAC AAA CAA GTC CTA ATC GCA TCT 390Asn Ile Asp Lys Val Ile Gly Glu Asn Lys Gln Val Leu Ile Ala Ser
105 110 115ACT TTA ACG CTG TTT AAA GCG GGT GGC TCT CAT TCT TAT GCG TTG GCT 438Thr Leu Thr Leu Phe Lys Ala Gly Gly Ser His Ser Tyr Ala Leu Ala120 125 130 135GTA TCT GTT GCA GAT GCA ATG GTA AGA CAA ACT CTA GGG CAT GTT ATG 486Val Ser Val Ala Asp Ala Met Val Arg Gln Thr Leu Gly His Val Met
140 145150TGG TGG GTA AAG TAGCACTTAA AAAAACTTTG GGCGTTTTGG CTGGCCCTAT TGGTT 543Trp Trp Val Lys
155GGGT 547
(2) Sequence 1148 data:
(i) sequence characteristics:
(A) length: 155 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1148: met Asn Glu Asp Leu Thr Asn Ser Thr Glu Tyr Lys Arg Tyr Gly His 151015 Asp Tyr Ala Lys Tyr Pro Arg Arg Ile Ala Glu Glu Leu Gln His Tyr
20 25 30Gly Gly Asn Ser Phe Ala Asn Phe Phe Arg Asp Glu Gly Val Leu Tyr
35 40 45Lys Glu Ile Leu Cys Asp Ala Cys Asp His Leu Lys Val Asn Tyr Asn
50 55 60Glu Glu Ser Ala Thr Ser Leu Ile Glu Gln Asn Met Leu Ser Lys Leu65 70 75 80Leu Lys Asp Ser Leu Glu Lys Met Ser Arg Arg Glu Ile Lys Glu Leu
85 90 95Cys Asn Glu Leu Gly Met Thr Asn Ile Asp Lys Val Ile Gly Glu Asn
100 105 110Lys Gln Val Leu Ile Ala Ser Thr Leu Thr Leu Phe Lys Ala Gly Gly
115 120 125Ser His Ser Tyr Ala Leu Ala Val Ser Val Ala Asp Ala Met Val Arg
130 135 140Gln Thr Leu Gly HisVal Met Trp Trp Val Lys145 150 155
(2) Sequence 1149 data:
(i) sequence characteristics:
(A) length: 523 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...486
(D) Other information:
(xi) Description of the sequence: sequence 1149: TTATTTTAAA GGAATTTC ATG CAA ATC ATA GAA GGG AAA TTG CAA TTA CAA 51
Met Gln Ile Ile Glu Gly Lys Leu Gln Leu Gln
1 5 10GGG AAT GAA AGA GTC GCT ATT TTA ACA TCG CGC TTC AAT CAT ATC ATC 99Gly Asn Glu Arg Val Ala Ile Leu Thr Ser Arg Phe Asn His Ile Ile
15 20 25ACA GAC AGA TTG CAA GAA GGG GCG ATG GAC TGC TTT AAA AGG CAT GGG 147Thr Asp Arg Leu Gln Glu Gly Ala Met Asp Cys Phe Lys Arg His Gly
30 35 40GGC GAT GAG GAT CTT TTA GAC ATC GTG CTG GTG CCT GGG GCT TAT GAA 195Gly Asp Glu Asp Leu Leu Asp Ile Val Leu Val Pro Gly Ala Tyr Glu
45 50 55TTG CCT TTT ATT TTA GAC AAA TTA TTA GAG AGC GAA AAA TAC GAT GGC 243Leu Pro Phe Ile Leu Asp Lys Leu Leu Glu Ser Glu Lys Tyr Asp Gly60 65 70 75GTG TGC GTT TTG GGA GCG ATC ATT AGA GGGGGG ACT CCG CAT TTT GAT 291Val Cys Val Leu Gly Ala Ile Ile Arg Gly Gly Thr Pro His Phe Asp
80 85 90TAT GTG AGC GCG GAA GCG ACT AAG GGT ATT GCC CAT GCG ATG CTT AAA 339Tyr Val Ser Ala Glu Ala Thr Lys Gly Ile Ala His Ala Met Leu Lys
95 100 105TAC AGC ATG CCG GTA AGC TTT GGC GTG CTG ACC ACG GAC AAT ATT GAA 387Tyr Ser Met Pro Val Ser Phe Gly Val Leu Thr Thr Asp Asn Ile Glu
110 115 120CAA GCG ATT GAA AGA GCG GGC AGT AAA GCC GGC AAT AAG GGC TTT GAA 435Gln Ala Ile Glu Arg Ala Gly Ser Lys Ala Gly Asn Lys Gly Phe Glu
125 130 135GCG ATG AGC ACC CTC ATT GAA TTG TTG AGC TTG TGC CAA ACT CTC AAG 483Ala Met Ser Thr Leu Ile Glu Leu Leu Ser Leu Cys Gln Thr Leu Lys140 145 150 155GGT TAAAATGGCG ACACGAACTC AAGCCAGGGG GGCTGTG 523Gly
(2) Sequence 1150 data:
(i) sequence characteristics:
(A) length: 156 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1150: met Gln Ile Ile Glu Gly Lys Leu Gln Leu Gln Gly Asn Glu Arg Val 151015 Ala Ile Leu Thr Ser Arg Phe Asn His Ile Ile Thr Asp Arg Leu Gln
20 25 30Glu Gly Ala Met Asp Cys Phe Lys Arg His Gly Gly Asp Glu Asp Leu
35 4045Leu Asp Ile Val Leu Val Pro Gly Ala Tyr Glu Leu Pro Phe Ile Leu
50 55 60Asp Lys Leu Leu Glu Ser Glu Lys Tyr Asp Gly Val Cys Val Leu Gly65 70 75 80Ala Ile Ile Arg Gly Gly Thr Pro His Phe Asp Tyr Val Ser Ala Glu
85 90 95Ala Thr Lys Gly Ile Ala His Ala Met Leu Lys Tyr Ser Met Pro Val
100 105 110Ser Phe Gly Val Leu Thr Thr Asp Asn Ile Glu Gln Ala Ile Glu Arg
115 120 125Ala Gly Ser Lys Ala Gly Asn Lys Gly Phe Glu Ala Met Ser Thr Leu
130 135 140Ile Glu Leu Leu Ser Leu Cys Gln Thr Leu Lys Gly145 150 155
(2) Sequence 1151 data:
(i) sequence characteristics:
(A) length: 1724 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...1656
(D) Other information:
(xi) Description of the sequence: sequence 1151: TATTATTAAG GATACAAA ATG GCA AAA GAA ATC AAA TTT TCA GAT AGC GCG 51
Met Ala Lys Glu Ile Lys Phe Ser Asp Ser Ala
1 510AGA AAC CTT TTA TTT GAA GGC GTG AGA CAA CTC CAT GAC GCT GTT AAA 99Arg Asn Leu Leu Phe Glu Gly Val Arg Gln Leu His Asp Ala Val Lys
15 20 25GTA ACC ATG GGG CCA AGA GGC AGG AAC GTG TTG ATC CAA AAA AGC TAT 147Val Thr Met Gly Pro Arg Gly Arg Asn Val Leu Ile Gln Lys Ser Tyr
30 35 40GGC GCT CCA AGC ATC ACT AAA GAT GGC GTG AGC GTG GCT AAA GAG ATT 195Gly Ala Pro Ser Ile Thr Lys Asp Gly Val Ser Val Ala Lys Glu Ile
45 50 55GAA TTA AGT TGC CCG GTA GCT AAC ATG GGC GCT CAA CTC GTT AAA GAA 243Glu Leu Ser Cys Pro Val Ala Asn Met Gly Ala Gln Leu Val Lys Glu60 65 70 75GTA GCG AGC AAA ACC GCT GAT GCT GCC GGC GAT GGC ACG ACC ACA GCG 291Val Ala Ser Lys Thr Ala Asp Ala Ala Gly Asp Gly Thr Thr Thr Ala
80 85 90ACC GTG CTG GCT TAT AGC ATT TTT AAA GAA GGT TTG AGG AAC ATC ACG 339Thr Val Leu Ala Tyr Ser Ile Phe Lys Glu Gly Leu Arg Asn Ile Thr
95 100 105GCT GGG GCT AAC CCT ATT GAA GTG AAA CGA GGC ATG GAT AAA GCC GCT 387Ala Gly Ala Asn Pro Ile Glu Val Lys Arg Gly Met Asp Lys Ala Ala
110 115 120GAA GCC ATT ATT AAT GAG CTT AAA AAA GCG AGC AAA AAA GTG GGC GGT 435Glu Ala Ile Ile Asn Glu Leu Lys Lys Ala Ser Lys Lys Val Gly Gly
125 130 135AAA GAA GAA ATC ACC CAA GTG GCG ACC ATT TCT GCA AAC TCC GAT CAC 483Lys Glu Glu Ile Thr Gln Val Ala Thr Ile Ser Ala Asn Ser Asp His140 145 150 155AAT ATC GGG AAA CTC ATC GCT GAC GCT ATG GAA AAA GTG GGT AAA GAC 531Asn Ile GlyLys Leu Ile Ala Asp Ala Met Glu Lys Val Gly Lys Asp
160 165 170GGC GTG ATC ACC GTT GAA GAA GCT AAG GGC ATT GAA GAT GAA CTA GAT 579Gly Val Ile Thr Val Glu Glu Ala Lys Gly Ile Glu Asp Glu Leu Asp
175 180 185GTT GTA GAA GGC ATG CAA TTT GAT AGA GGC TAC CTC TCC CCT TAT TTT 627Val Val Glu Gly Met Gln Phe Asp Arg Gly Tyr Leu Ser Pro Tyr Phe
190 195 200GTA ACA AAC GCT GAG AAA ATG ACC GCT CAA TTG GAT AAC GCT TAC ATC 675Val Thr Asn Ala Glu Lys Met Thr Ala Gln Leu Asp Asn Ala Tyr Ile
205 210 215CTT TTA ACG GAT AAA AAA ATC TCT AGC ATG AAA GAC ATT CTC CCG CTA 723Leu Leu Thr Asp Lys Lys Ile Ser Ser Met Lys Asp Ile Leu Pro Leu220 225 230 235CTA GAA AAA ACC ATG AAA GAG GGC AAA CCG CTT TTA ATC ATC GCT GAA 771Leu Glu Lys Thr Met Lys Glu Gly Lys Pro Leu Leu Ile Ile Ala Glu
240 245 250GAC ATT GAG GGC GAA GCT TTA ACG ACT CTA GTG GTG AAT AAA TTA AGA 819Asp Ile Glu Gly Glu Ala Leu Thr Thr Leu Val Val Asn Lys Leu Arg
255 260 265GGC GTG TTG AAT ATC GCA GCG GTT AAA GCT CCA GGC TTT GGG GAC AGA 867Gly Val Leu Asn Ile Ala Ala Val Lys Ala Pro Gly Phe Gly Asp Arg
270 275 280AGA AAA GAA ATG CTC AAA GAC ATC GCT ATT TTA ACC GGC GGT CAA GTT 915Arg Lys Glu Met Leu Lys Asp Ile Ala Ile Leu Thr Gly Gly Gln Val
285 290 295ATT AGC GAA GAA TTG GGC TTG AGT CTA GAA AAC GCT GAA GTG GAG TTT 963Ile Ser Glu Glu Leu Gly Leu Ser Leu Glu Asn Ala Glu Val Glu Phe300305 310 315TTA GGC AAA GCC GGA AGG ATT GTG ATT GAC AAA GAC AAC ACC ACG ATC 1011Leu Gly Lys Ala Gly Arg Ile Val Ile Asp Lys Asp Asn Thr Thr Ile
320 325 330GTA GAT GGC AAA GGC CAT AGC CAT GAT GTC AAA GAC AGA GTC GCG CAA 1059Val Asp Gly Lys Gly His Ser His Asp Val Lys Asp Arg Val Ala Gln
335 340 345ATC AAA ACC CAA ATT GCA AGC ACG ACA AGC GAT TAT GAC AAA GAA AAA 1107Ile Lys Thr Gln Ile Ala Ser Thr Thr Ser Asp Tyr Asp Lys Glu Lys
350 355 360TTG CAA GAA AGG TTG GCT AAA CTC TCT GGC GGT GTG GCT GTG ATT AAA 1155Leu Gln Glu Arg Leu Ala Lys Leu Ser Gly Gly Val Ala Val Ile Lys
365 370 375GTG GGC GCT GCG AGT GAA GTG GAA ATG AAA GAG AAA AAA GAC CGG GTT 1203Val Gly Ala Ala Ser Glu Val Glu Met Lys Glu Lys Lys Asp Arg Val380 385 390 395GAT GAT GCG TTG AGC GCG ACT AAA GCG GCT GTT GAA GAA GGT ATT GTG 1251Asp Asp Ala Leu Ser Ala Thr Lys Ala Ala Val Glu Glu Gly Ile Val
400 405 410ATT GGC GGC GGT GCG GCT CTC ATT CGC GCG GCT CAA AAA GTG CAT TTG 1299Ile Gly Gly Gly Ala Ala Leu Ile Arg Ala Ala Gln Lys Val His Leu
415 420 425AAT TTG CAC GAT GAT GAA AAA GTG GGC TAT GAA ATC ATC ATG CGC GCC 1347Asn Leu His Asp Asp Glu Lys Val Gly Tyr Glu Ile Ile Met Arg Ala
430 435 440ATT AAA GCC CCA TTA GCT CAA ATC GCT ATC AAT GCC GGT TAT GAT GGC 1395Ile Lys Ala Pro Leu Ala Gln Ile Ala Ile Asn Ala Gly Tyr Asp Gly
445 450455GGT GTG GTC GTG AAT GAA GTA GAA AAA CAC GAA GGG CAT TTT GGT TTT 1443Gly Val Val Val Asn Glu Val Glu Lys His Glu Gly His Phe Gly Phe460 465 470 475AAC GCT AGC AAT GGC AAG TAT GTG GAT ATG TTT AAA GAA GGC ATT ATT 1491Asn Ala Ser Asn Gly Lys Tyr Val Asp Met Phe Lys Glu Gly Ile Ile
480 485 490GAC CCC TTA AAA GTA GAA AGG ATC GCT TTA CAA AAT GCG GTT TCG GTT 1539Asp Pro Leu Lys Val Glu Arg Ile Ala Leu Gln Asn Ala Val Ser Val
495 500 505TCA AGC CTG CTT TTA ACC ACA GAA GCC ACC GTG CAT GAA ATC AAA GAA 1587Ser Ser Leu Leu Leu Thr Thr Glu Ala Thr Val His Glu Ile Lys Glu
510 515 520GAA AAA GCG GCC CCA GCA ATG CCT GAT ATG GGT GGC ATG GGC GGT ATG 1635Glu Lys Ala Ala Pro Ala Met Pro Asp Met Gly Gly Met Gly Gly Met
525 530 535GGA GGC ATG GGT GGC ATG ATG TAAGCCCCCT TGCTTTTTAG TATCATCTGC TTTT 1690Gly Gly Met Gly Gly Met Met540 545AAAATCCCCT AAAATCCCCC CTTTCTAAAA TCTC 1724
(2) Sequence 1152 data:
(i) sequence characteristics:
(A) length: 546 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1152: met Ala Lys Glu Ile Lys Phe Ser Asp Ser Ala Arg Asn Leu Leu Phe 151015 Glu Gly Val Arg Gln Leu His Asp Ala Val Lys Val Thr Met Gly Pro
2025 30Arg Gly Arg Asn Val Leu Ile Gln Lys Ser Tyr Gly Ala Pro Ser Ile
35 40 45Thr Lys Asp Gly Val Ser Val Ala Lys Glu Ile Glu Leu Ser Cys Pro
50 55 60Val Ala Asn Met Gly Ala Gln Leu Val Lys Glu Val Ala Ser Lys Thr65 70 75 80Ala Asp Ala Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala Tyr
85 90 95Ser Ile Phe Lys Glu Gly Leu Arg Asn Ile Thr Ala Gly Ala Asn Pro
100 105 110Ile Glu Val Lys Arg Gly Met Asp Lys Ala Ala Glu Ala Ile Ile Asn
115 120 125Glu Leu Lys Lys Ala Ser Lys Lys Val Gly Gly Lys Glu Glu Ile Thr
130 135 140Gln Val Ala Thr Ile Ser Ala Asn Ser Asp His Asn Ile Gly Lys Leu145 150 155 160Ile Ala Asp Ala Met Glu Lys Val Gly Lys Asp Gly Val Ile Thr Val
165 170 175Glu Glu Ala Lys Gly Ile Glu Asp Glu Leu Asp Val Val Glu Gly Met
180 185 190Gln Phe Asp Arg Gly Tyr Leu Ser Pro Tyr Phe Val Thr Asn Ala Glu
195 200 205Lys Met Thr Ala Gln Leu Asp Asn Ala Tyr Ile Leu Leu Thr Asp Lys
210 215 220Lys Ile Ser Ser Met Lys Asp Ile Leu Pro Leu Leu Glu Lys Thr Met225 230 235 240Lys Glu Gly Lys Pro Leu Leu Ile Ile Ala Glu Asp Ile Glu Gly Glu
245 250 255Ala Leu Thr Thr Leu Val Val Asn Lys Leu Arg Gly Val Leu Asn Ile
260 265 270Ala Ala Val Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Glu Met Leu
275 280 285Lys Asp Ile Ala Ile Leu Thr Gly Gly G;n Val Ile Ser Glu Glu Leu
290 295 300Gly Leu Ser Leu Glu Asn Ala Glu Val Glu Phe Leu Gly Lys Ala Gly305 310 315 320Arg Ile Val Ile Asp Lys Asp Asn Thr Thr Ile Val Asp Gly Lys Gly
325 330 335His Ser His Asp Val Lys Asp Arg Val Ala Gln Ile Lys Thr Gln Ile
340 345 350Ala Ser Thr Thr Ser Asp Tyr Asp Lys Glu Lys Leu Gln Glu Arg Leu
355 360 365Ala Lys Leu Ser Gly Gly Val Ala Val Ile Lys Val Gly Ala Ala Ser
370 375 380Glu Val Glu Met Lys Glu Lys Lys Asp Arg Val Asp Asp Ala Leu Ser385 390 395 400Ala Thr Lys Ala Ala Val Glu Glu Gly Ile Val Ile Gly Gly Gly Ala
405 410 415Ala Leu Ile Arg Ala Ala Gln Lys Val His Leu Asn Leu His Asp Asp
420 425 430Glu Lys Val Gly Tyr Glu Ile Ile Met Arg Ala Ile Lys Ala Pro Leu
435 440 445Ala Gln Ile Ala Ile Asn Ala Gly Tyr Asp Gly Gly Val Val Val Asn
450 455 460Glu Val Glu Lys His Glu Gly His Phe Gly Phe Asn Ala Ser Asn Gly465 470 475 480Lys Tyr Val Asp Met Phe Lys Glu Gly Ile Ile Asp Pro Leu Lys Val
485 490 495Glu Arg Ile Ala Leu Gln Asn Ala Val Ser Val Ser Ser Leu Leu Leu
500 505 510Thr Thr Glu Ala Thr Val His Glu Ile Lys Glu Glu Lys Ala Ala Pro
515 520 525Ala Met Pro Asp Met Gly Gly Met Gly Gly Met Gly Gly Met Gly Gly
530 535 540Met Met545
(2) Sequence 1153 data:
(i) sequence characteristics:
(A) length: 881 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 14...838
(D) Other information:
(xi) Description of the sequence: sequence 1153: CTAGGAGGTT TGC ATG CAA GAG TTT TTA GGT TTT GGT GTG GTG GGG AAT 49
Met Gln Glu Phe Leu Gly Phe Gly Val Val Gly Asn
1 5 10TTT GCA GGG CAT TTG GAG CAA GCA GGA GAG AGT CAT AGT TTT ATT AAC 97Phe Ala Gly His Leu Glu Gln Ala Gly Glu Ser His Ser Phe Ile Asn
15 20 25ATG AAA AGC GAA GAA AAG GAC GCC CCT AAG GGG CTA TTC CCT TTT TAT 145Met Lys Ser Glu Glu Lys Asp Ala Pro Lys Gly Leu Phe Pro Phe Tyr
30 35 40ATC CCC TAT GAA AAT TGT TAT TTG GGG CGT TGT TGC ATT GAT AAC CAT 193Ile Pro Tyr Glu Asn Cys Tyr Leu Gly Arg Cys Cys Ile Asp Asn His45 50 55 60AAG ATT ATT TTG CCT AGT GAT CTA GAT TTA AGG GTG CAA GCA GAG CCA 241Lys Ile Ile Leu Pro Ser Asp Leu Asp Leu Arg Val Gln Ala Glu Pro
65 70 75GAA ATC GCT TTA GAA TGC GAT GTT AAA TAC GAT GAA AAA CAT TTG GTT 289Glu Ile Ala Leu Glu Cys Asp Val Lys Tyr Asp Glu Lys His Leu Val
80 85 90GCA AAG CTC GTG CCT AAT TTT TTC ATG GCG TTT AAT GAC GCT TCT GTG 337Ala Lys Leu Val Pro Asn Phe Phe Met Ala Phe Asn Asp Ala Ser Val
95 100 105CGC AAT TTA GAC GCC GCA AAA CTC TCC CAA AAA AAG AAT TTT TCA CCG 385Arg Asn Leu Asp Ala Ala Lys Leu Ser Gln Lys Lys Asn Phe Ser Pro
110 115 120GCT TCT AAA GGT ATA GGG CAG AAA TTG CCC ATT GAC AGG TTT GTT TAT 433Ala Ser Lys Gly Ile Gly Gln Lys Leu Pro Ile Asp Arg Phe Val Tyr125 130 135 140GGG GGG GTG TGT AAC AAT TTC TCT ATC GCG TCT TTT TTG AAA TAC AAT 481Gly Gly Val Cys Asn Asn Phe Ser Ile Ala Ser Phe Leu Lys Tyr Asn
145 150 155AAT GTT TGG CAC ATT TAT GGG GAA AAC AGC AAA TTG CTC AAA TAC GAG 529Asn Val Trp His Ile Tyr Gly Glu Asn Ser Lys Leu Leu Lys Tyr Glu
160 165 170TTT TTT TAT CAA AAG CTT TTA GAT TGG ATT AAA GAC CAA TTA AAC CAC 577Phe Phe Tyr Gln Lys Leu Leu Asp Trp Ile Lys Asp Gln Leu Asn His
175 180185CAA CAA GAT GGC GAC TCT TTA GAG GCT CTA AGA CCT TTT TTA GAG CGC 625Gln Gln Asp Gly Asp Ser Leu Glu Ala Leu Arg Pro Phe Leu Glu Arg
190 195 200CAT AAT TTC CCC ACT AAA ATG ATT TTT GCA ATA GGG GCT ACC CCT TAT 673His Asn Phe Pro Thr Lys Met Ile Phe Ala Ile Gly Ala Thr Pro Tyr205 210 215 220ATG CCT TTT GCG CAA GAG CAT TTT TTG CAA AAA GGC GAT GAG GTG GTG 721Met Pro Phe Ala Gln Glu His Phe Leu Gln Lys Gly Asp Glu Val Val
225 230 235ATC GTT GCT TAC AAC CAT TTA CAA TAC AGT TTT GAA AAG ATT CAA AAC 769Ile Val Ala Tyr Asn His Leu Gln Tyr Ser Phe Glu Lys Ile Gln Asn
240 245 250CTC TTA GAA GAG GAC GCC CTA CAA GCC AAA GAA CAC GCT AAT CTT TCT 817Leu Leu Glu Glu Asp Ala Leu Gln Ala Lys Glu His Ala Asn Leu Ser
255 260 265TAT GTC TAT CAA ATC GTA GAA TAGTAAGGCT TTTACACTCT TTGGCTTTGC TTTT 872Tyr Val Tyr Gln Ile Val Glu
270 275TTACCCTTT 881
(2) Sequence 1154 data:
(i) sequence characteristics:
(A) length: 275 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1154: met Gln Glu Phe Leu Gly Phe Gly Val Val Gly Asn Phe Ala Gly His 151015 Leu Glu Gln Ala Gly Glu Ser His Ser Phe Ile Asn Met Lys Ser Glu
20 25 30Glu Lys Asp Ala Pro Lys Gly Leu Phe Pro Phe Tyr Ile Pro Tyr Glu
35 40 45Asn Cys Tyr Leu Gly Arg Cys Cys Ile Asp Asn His Lys Ile Ile Leu
50 55 60Pro Ser Asp Leu Asp Leu Arg Val Gln Ala Glu Pro Glu Ile Ala Leu65 70 75 80Glu Cys Asp Val Lys Tyr Asp Glu Lys His Leu Val Ala Lys Leu Val
85 90 95Pro Asn Phe Phe Met Ala Phe Asn Asp Ala Ser Val Arg Asn Leu Asp
100 105 110Ala Ala Lys Leu Ser Gln Lys Lys Asn Phe Ser Pro Ala Ser Lys Gly
115 120 125Ile Gly Gln Lys Leu Pro Ile Asp Arg Phe Val Tyr Gly Gly Val Cys
130 135 140Asn Asn Phe Ser Ile Ala Ser Phe Leu Lys Tyr Asn Asn Val Trp His145 150 155 160Ile Tyr Gly Glu Asn Ser Lys Leu Leu Lys Tyr Glu Phe Phe Tyr Gln
165 170 175Lys Leu Leu Asp Trp Ile Lys Asp Gln Leu Asn His Gln Gln Asp Gly
180 185 190Asp Ser Leu Glu Ala Leu Arg Pro Phe Leu Glu Arg His Asn Phe Pro
195 200 205Thr Lys Met Ile Phe Ala Ile Gly Ala Thr Pro Tyr Met Pro Phe Ala
210 215 220Gln Glu His Phe Leu Gln Lys Gly Asp Glu Val Val Ile Val Ala Tyr225 230 235 240Asn His Leu Gln Tyr Ser Phe Glu Lys Ile Gln Asn Leu Leu Glu Glu
245 250 255Asp Ala Leu Gln Ala Lys Glu His Ala Asn Leu Ser Tyr Val Tyr Gln
260 265 270Ile Val Glu
275
(2) Sequence 1155 data:
(i) sequence characteristics:
(A) length: 337 bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 40...300
(D) Other information:
(xi) Description of the sequence: sequence 1155: AGCTCCGAGT TTAGCGAATT GGTTTATGGG AATTTTTTA ATG ATT ATC CTG TCA 54
Met Ile Ile Leu Ser
1 5GCG AGC GTG AAG AAT TTG CGT GAA ATT TCG GTT AAA GAA AAA TTT TTA 102Ala Ser Val Lys Asn Leu Arg Glu Ile Ser Val Lys Glu Lys Phe Leu
10 15 20TGG CTG AAC GCT AAG TCT TAT TTG ATT TCT GTT TTT GCG CCT TTT ATC 150Trp Leu Asn Ala Lys Ser Tyr Leu Ile Ser Val Phe Ala Pro Phe Ile
25 30 35TTG CTC CCT TGG ATT GAT TTG TTG AGC GCT TTT TTA TTG TAT TTA GGG 198Leu Leu Pro Trp Ile Asp Leu Leu Ser Ala Phe Leu Leu Tyr Leu Gly
40 45 50TTT TTA GCG CTC TTT AGC GTG CTG GAATTT TTT GAT GAA GAC ATT GCA 246Phe Leu Ala Leu Phe Ser Val Leu Glu Phe Phe Asp Glu Asp Ile Ala
55 60 65GAT ATT ATC GTG GCT AAA AGC AAA ATA AAG ACT AAA ACC AAA TGT TAT 294Asp Ile Ile Val Ala Lys Ser Lys Ile Lys Thr Lys Thr Lys Cys Tyr70 75 80 85AGA GCG TAGAATGTTA GAAAAGCTTT TAAGCGCTAT CAAACAA 337Arg Ala
(2) Sequence 1156 data:
(i) sequence characteristics:
(A) length: 87 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1156: met Ile Ile Leu Ser Ala Ser Val Lys Asn Leu Arg Glu Ile Ser Val 151015 Lys Glu Lys Phe Leu Trp Leu Asn Ala Lys Ser Tyr Leu Ile Ser Val
20 25 30Phe Ala Pro Phe Ile Leu Leu Pro Trp Ile Asp Leu Leu Ser Ala Phe
35 40 45Leu Leu Tyr Leu Gly Phe Leu Ala Leu Phe Ser Val Leu Glu Phe Phe
50 55 60Asp Glu Asp Ile Ala Asp Ile Ile Val Ala Lys Ser Lys Ile Lys Thr65 70 75 80Lys Thr Lys Cys Tyr Arg Ala
85
(2) Sequence 1157 data:
(i) sequence characteristics:
(A) length: 1044 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 15...977
(D) Other information:
(xi) Description of the sequence: sequence 1157: ATTAAGGGGA AGTC ATG GCT GAT AGT TTA GCG GGC ATT GAT CAA GTT ACG 50
Met Ala Asp Ser Leu Ala Gly Ile Asp Gln Val Thr
1 5 10AGT TTG CAT AAA AAT AAC GAG TTA CAA TTG TTG TGT TTC AGG CTG GGT 98Ser Leu His Lys Asn Asn Glu Leu Gln Leu Leu Cys Phe Arg Leu Gly
15 20 25AAA AAC AAG GAT TTG TAT GCG GTC AAT GTT TTT AAG ATC CGT GAA GTG 146Lys Asn Lys Asp Leu Tyr Ala Val Asn Val Phe Lys Ile Arg Glu Val
30 35 40GTG AAA TAC CAT GGC AAT CTC ACC ATC ATT AGC CAC GAA AAC AAT TCG 194Val Lys Tyr His Gly Asn Leu Thr Ile Ile Ser His Glu Asn Asn Ser45 50 55 60CTC GTT GAG GGG CTA ATC ATT ATA AGA GAA CTC ACC ATT CCC TTG ATT 242Leu Val Glu Gly Leu Ile Ile Ile Arg Glu Leu Thr Ile Pro Leu Ile
65 70 75GAT ATG AAA AAA TGG TTT TAT TAT GAC AGC CAA AAC AAA AAC AAG GAT 290Asp Met Lys Lys Trp Phe Tyr Tyr Asp Ser Gln Asn Lys Asn Lys Asp
80 85 90TTA CGC CCT TAT AGG ATA GAA AAA GAA AAA GGC GAA GAT GAT ATT GTT 338Leu Arg Pro Tyr Arg Ile Glu Lys Glu Lys Gly Glu Asp Asp Ile Val
95 100 105ATG ATT TGT GAG TTT TCT CGC TGG ACT ATA GGG GTT AGG ATC TAT GAA 386Met Ile Cys Glu Phe Ser Arg Trp Thr Ile Gly Val Arg Ile Tyr Glu
110 115 120GCG GAT AGG ATT TTG AGC AAG AAA TGG ACT GAA ATG GAG CAA AGC GCT 434Ala Asp Arg Ile Leu Ser Lys Lys Trp Thr Glu Met Glu Gln Ser Ala125 130 135 140GGG CTA GGG GGA TCT GCA GGC AAT AAC AAA CTC GTG AGC CGC ACG CGC 482Gly Leu Gly Gly Ser Ala Gly Asn Asn Lys Leu Val Ser Arg Thr Arg
145 150 155TAT TTT GAT GGG CGC TTG GTG CAA GTG GTG GAT ATT GAA AAA ATG CTT 530Tyr Phe Asp Gly Arg Leu Val Gln Val Val Asp Ile Glu Lys Met Leu
160 165 170ATA GAC GTG TTC CCT TGG ATT GAA GAT GAA AAA CAC AAC GAT TTA GAG 578Ile Asp Val Phe Pro Trp Ile Glu Asp Glu Lys His Asn Asp Leu Glu
175 180 185ACG CTT TCT AAA ATC CAT TCT AAC CAA TGC GTT TTG CTT GCT GAT GAC 626Thr Leu Ser Lys Ile His Ser Asn Gln Cys Val Leu Leu Ala Asp Asp
190 195 200TCC CCA AGC GTT TTG AAA ACC ATG CAA ATG ATT TTA GAC AAG CTG GGC 674Ser Pro Ser Val Leu Lys Thr Met Gln Met Ile Leu Asp Lys Leu Gly205 210 215 220GTC AAG CAT ATA GAT TTT ATC AAT GGT AAA ACC TTA CrA GAG CAT TTA 722Val Lys His Ile Asp Phe Ile Asn Gly Lys Thr Leu Leu Glu His Leu
225 230 235TTC AAC CCC ACA ACC GAT GTG AGT AAT ATT GGC CTG ATT ATT ACC GAT 770Phe Asn Pro Thr Thr Asp Val Ser Asn Ile Gly Leu Ile Ile Thr Asp
240 245 250TTG GAA ATG CCA GAG GCG AGC GGT TTT GAA GTG ATC AAG CAG GTT AAA 818Leu Glu Met Pro Glu Ala Ser Gly Phe Glu Val Ile Lys Gln Val Lys
255 260 265AAC AAT CCT TTG ACT TCA AAA ATC CCT ATC GTG GTC AAT TCT TCT ATG 866Asn Asn Pro Leu Thr Ser Lys Ile Pro Ile Val Val Asn Ser Ser Met
270 275 280AGC GGG AGT TCT AAT GAA GAC ATG GCC AGG AGT TTG AAG GCC GAT GAT 914Ser Gly Ser Ser Asn Glu Asp Met Ala Arg Ser Leu Lys Ala Asp Asp285 290 295 300TTC ATT TCC AAG TCT AAC CCC AAA GAC ATC CAG CGA GTG GTT AAG CAA 962Phe Ile Ser Lys Ser Asn Pro Lys Asp Ile Gln Arg Val Val Lys Gln
305 310 315TTT TTG GAA TTA GCA TGAAAAAATA CAGCACTATC CCCACCCCTT GCTACGTGTT A 1018Phe Leu Glu Leu Ala
320GAGAGCGAAC GCTTAGAAAA AAACGC 1044
(2) Sequence 1158 data:
(i) sequence characteristics:
(A) length: 321 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1158: met Ala Asp Ser Leu Ala Gly Ile Asp Gln Val Thr Ser Leu His Lys 151015 Asn Asn Glu Leu Gln Leu Leu Cys Phe Arg Leu Gly Lys Asn Lys Asp
20 25 30Leu Tyr Ala Val Asn Val Phe Lys Ile Arg Glu Val Val Lys Tyr His
35 40 45Gly Asn Leu Thr Ile Ile Ser His Glu Asn Asn Ser Leu Val Glu Gly
50 55 60Leu Ile Ile Ile Arg Glu Leu Thr Ile Pro Leu Ile Asp Met Lys Lys65 70 75 80Trp Phe Tyr Tyr Asp Ser Gln Asn Lys Asn Lys Asp Leu Arg Pro Tyr
85 90 95Arg Ile Glu Lys Glu Lys Gly Glu Asp Asp Ile Val Met Ile Cys Glu
100 105 110Phe Ser Arg Trp Thr Ile Gly Val Arg Ile Tyr Glu Ala Asp Arg Ile
115 120 125Leu Ser Lys Lys Trp Thr Glu Met Glu Gln Ser Ala Gly Leu Gly Gly
130 135 140Ser Ala Gly Asn Asn Lys Leu Val Ser Arg Thr Arg Tyr Phe Asp Gly145 150 155 160Arg Leu Val Gln Val Val Asp Ile Glu Lys Met Leu Ile Asp Val Phe
165 170 175Pro Trp Ile Glu Asp Glu Lys His Asn Asp Leu Glu Thr Leu Ser Lys
180 185 190Ile His Ser Asn Gln Cys Val Leu Leu Ala Asp Asp Ser Pro Ser Val
195 200 205Leu Lys Thr Met Gln Met Ile Leu Asp Lys Leu Gly Val Lys His Ile
210 215 220Asp Phe Ile Asn Gly Lys Thr Leu Leu Glu His Leu Phe Asn Pro Thr225 230 235 240Thr Asp Val Ser Asn Ile Gly Leu Ile Ile Thr Asp Leu Glu Met Pro
245 250 255Glu Ala Ser Gly Phe Glu Val Ile Lys Gln Val Lys Asn Asn Pro Leu
260 265 270Thr Ser Lys Ile Pro Ile Val Val Asn Ser Ser Met Ser Gly Ser Ser
275280 285Asn Glu Asp Met Ala Arg Ser Leu Lys Ala Asp Asp Phe Ile Ser Lys
290 295 300Ser Asn Pro Lys Asp Ile Gln Arg Val Val Lys Gln Phe Leu Glu Leu305 310 315 320Ala
(2) Sequence 1159 data:
(i) sequence characteristics:
(A) length: 633bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 37...618
(D) Other information:
(xi) Description of the sequence: sequence 1159: ATCTGCTTAA ACACAAAAAA GAGTAAAATA ACACGC ATG AAA AAA TTC TTA TTT 54
Met Lys Lys Phe Leu Phe
1 5AAA CAA AAA TIT TGT GAA AGC CTG CCC AAA AGC TTT TCT AAA ACT TTG 102Lys Gln Lys Phe Cys Glu Ser Leu Pro Lys Ser Phe Ser Lys Thr Leu
10 15 20TTA GCG CTC AGT TTG GGC TTG ATT TTA TTA GGC ATT TTT GCG CCT TTC 150Leu Ala Leu Ser Leu Gly Leu Ile Leu Leu Gly Ile Phe Ala Pro Phe
25 30 35CCT AAA GTC CCT AAA CAG CCT AGC GTG CCT TTA ATG TTT CAT TTC ACC 198Pro Lys Val Pro Lys Gln Pro Ser Val Pro Leu Met Phe His Phe Thr
40 4550GAG CAT TAT GCG CGC TTT ATC CCT ACG ATT TTA TCT GTG GCG ATT CCC 246Glu His Tyr Ala Arg Phe Ile Pro Thr Ile Leu Ser Val Ala Ile Pro55 60 65 70TTA ATC CAA AGA GAT GCG GTA GGG CTT TTT CAA GTC GCT AAC GCT TCT 294Leu Ile Gln Arg Asp Ala Val Gly Leu Phe Gln Val Ala Asn Ala Ser
75 80 85ATC GCT ACA ACC CTT CTC ACG CAC ACC ACC AAA AGA GCC TTA AAC CAT 342Ile Ala Thr Thr Leu Leu Thr His Thr Thr Lys Arg Ala Leu Asn His
90 95 100GTA ACA ATC AAC GAT CAG CGT TTG GGC GAG CGC CCT TAT GGA GGT AAT 390Val Thr Ile Asn Asp Gln Arg Leu Gly Glu Arg Pro Tyr Gly Gly Asn
105 110 115TTC AAC ATG CCA AGC GGG CAT TCG TCT ATG GTG GGT TTG GCG GTG GCG 438Phe Asn Met Pro Ser Gly His Ser Ser Met Val Gly Leu Ala Val Ala
120 125 130TTT TTA ATG CGC CGC TAT TCT TTT AAA AAA TAC TTT TGG CTC TTG CCC 486Phe Leu Met Arg Arg Tyr Ser Phe Lys Lys Tyr Phe Trp Leu Leu Pro135 140 145 150CTA GTC CCT TTG ACC ATG CTC GCT CGC ATT TAT TTA GAC ATG CAC ACC 534Leu Val Pro Leu Thr Met Leu Ala Arg Ile Tyr Leu Asp Met His Thr
155 160 165ATT GGC GCG GTG CTG ACC GGG CTT GGC GTT GGA ATG TTG TGC GTA ASC 582Ile Gly Ala Val Leu Thr Gly Leu Gly Val Gly Met Leu Cys Val Xaa
170 175 180TTT TTA CAA GCC CCA AAA AGC CTT AAT CAA AAG CTT TAGTTTCTGT TTTTA 633Phe Leu Gln Ala Pro Lys Ser Leu Asn Gln Lys Leu
185 190
(2) Sequence 1160 data:
(i)sequence characteristics:
(A) length: 194 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1160: met Lys Lys Phe Leu Phe Lys Gln Lys Phe Cys Glu Ser Leu Pro Lys 151015 Ser Phe Ser Lys Thr Leu Leu Ala Leu Ser Leu Gly Leu Ile Leu Leu
20 25 30Gly Ile Phe Ala Pro Phe Pro Lys Val Pro Lys Gln Pro Ser Val Pro
35 40 45Leu Met Phe His Phe Thr Glu His Tyr Ala Arg Phe Ile Pro Thr Ile
50 55 60Leu Ser Val Ala Ile Pro Leu Ile Gln Arg Asp Ala Val Gly Leu Phe65 70 75 80Gln Val Ala Asn Ala Ser Ile Ala Thr Thr Leu Leu Thr His Thr Thr
85 90 95Lys Arg Ala Leu Asn His Val Thr Ile Asn Asp Gln Arg Leu Gly Glu
100 105 110Arg Pro Tyr Gly Gly Asn Phe Asn Met Pro Ser Gly His Ser Ser Met
115 120 125Val Gly Leu Ala Val Ala Phe Leu Met Arg Arg Tyr Ser Phe Lys Lys
130 135 140Tyr Phe Trp Leu Leu Pro Leu Val Pro Leu Thr Met Leu Ala Arg Ile145 150 155 160Tyr Leu Asp Met His Thr Ile Gly Ala Val Leu Thr Gly Leu Gly Val
165 170 175Gly Met Leu Cys Val Xaa Phe Leu Gln Ala Pro Lys Ser Leu Asn Gln
180 185 190Lys Leu
(2) Sequence 1161 data:
(i) sequence characteristics:
(A) length: 1091 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 57...1040
(D) Other information:
(xi) Description of the sequence: sequence 1161: ATTTCCCTTT GTTCGTTTAT GTTTATAAAG AAAGCAACCA GGTCAGTTTT ATCGCC ATG 59
Met
1ATG GTT GTG GTG CTT TTT TGC GTT AAT GGC GCT CTT TTT TTG GCG TTA 107Met Val Val Val Leu Phe Cys Val Asn Gly Ala Leu Phe Leu Ala Leu
5 10 15GGC TTG ATC TCT GCT TCT TTG ATG CGT TGG AGT GCG ATA GTT TTT AGC 155Gly Leu Ile Ser Ala Ser Leu Met Arg Trp Ser Ala Ile Val Phe Ser
20 25 30CTG CTC AAT TCC GTT GCT TTC TAT TTC ATT AGC GCT TAT AAG GTG TTT 203Leu Leu Asn Ser Val Ala Phe Tyr Phe Ile Ser Ala Tyr Lys Val Phe
35 40 45TTA AAT AAG AGC ATG ATG GGT AAT GTC TTA AAC ACC AAC ACG CAT GAA 251Leu Asn Lys Ser Met Met Gly Asn Val Leu Asn Thr Asn Thr His Glu50 55 60 65GTT TTA GGCTTT TTG AGC GTC AAA TTA TTC GTT TTT ATC GTT GTT TTT 299Val Leu Gly Phe Leu Ser Val Lys Leu Phe Val Phe Ile Val Val Phe
70 75 80GGG GTG TTG CCT GGC TAT GTC ATC TAT AAA ATC CCC CTT AAA AAT TCT 347Gly Val Leu Pro Gly Tyr Val Ile Tyr Lys Ile Pro Leu Lys Asn Ser
85 90 95TCT AAA AAA GCG CCC TTT TTA GCG ATC TTG GCG TTA GTG TTT ATC TTT 395Ser Lys Lys Ala Pro Phe Leu Ala Ile Leu Ala Leu Val Phe Ile Phe
100 105 110ATC GCT AGC GCT TTA GCT AAC ACT AAA AAT TGG CTG TGG TTT GAC AAG 443Ile Ala Ser Ala Leu Ala Asn Thr Lys Asn Trp Leu Trp Phe Asp Lys
115 120 125CAT GCG AAA TTC ATA GGG GGC TTA ATT TTG CCC TTC GCT TAT AGC GTG 491His Ala Lys Phe Ile Gly Gly Leu Ile Leu Pro Phe Ala Tyr Ser Val130 135 140 145AAC GCT TTT AGA GTG AGC GCT CTC AAA TTT TTC GCC CCC ACC ATC AAG 539Asn Ala Phe Arg Val Ser Ala Leu Lys Phe Phe Ala Pro Thr Ile Lys
150 155 160CCG CTC CCT CTT TTT TCA CCC AAT CAT TCC CAT TCG TTT GTG GTG CTA 587Pro Leu Pro Leu Phe Ser Pro Asn His Ser His Ser Phe Val Val Leu
165 170 175GTC ATT GGC GAA AGC GCT AGG AAA CAT AAT TAC GCC CTT TAT GGC TAT 635Val Ile Gly Glu Ser Ala Arg Lys His Asn Tyr Ala Leu Tyr Gly Tyr
180 185 190CAA AAA CCC ACC ACC CCA AGA CTA AGC AAG CGT TTA GCC GAT AAT GAA 683Gln Lys Pro Thr Thr Pro Arg Leu Ser Lys Arg Leu Ala Asp Asn Glu
195 200 205CTC ACT CTT TTC AAC GCC ACT TCT TGC GCC ACT TAC ACG ACA GCG AGT 731Leu Thr Leu Phe Asn Ala Thr Ser Cys Ala Thr Tyr Thr Thr Ala Ser210 215 220 225TTG GAA TGC ATT TTA GAT TCT TCT TTT AAA AAC AAC GCT TAT GAA AAT 779Leu Glu Cys Ile Leu Asp Ser Ser Phe Lys Asn Asn Ala Tyr Glu Asn
230 235 240TTG CCA ACT TAC TTG ACT AAA GCC GGT ATC AAA GTC TTT TGG TAT AGC 827Leu Pro Thr Tyr Leu Thr Lys Ala Gly Ile Lys Val Phe Trp Tyr Ser
245 250 255GCG AAC GAC GGC GAA AAG AAT GTT AAG GTT ACA AGC TAT CTT AAA AAC 875Ala Asn Asp Gly Glu Lys Asn Val Lys Val Thr Ser Tyr Leu Lys Asn
260 265 270TAT GAA TTG ATT CAA AAA TGC CCC AAT TGT GAA GCG ATC GCT CCT TAT 923Tyr Glu Leu Ile Gln Lys Cys Pro Asn Cys Glu Ala Ile Ala Pro Tyr
275 280 285GAT GAA TCT TTA CTT TAT AAT TTG CCT GAC CTT TTA AAA GAA CAC TCT 971Asp Glu Ser Leu Leu Tyr Asn Leu Pro Asp Leu Leu Lys Glu His Ser290 295 300 305AAT GAA AAT GTC TTG CTC ATC TTA CAC TTG CAG GCT CGC ATG GCC CAA 1019Asn Glu Asn Val Leu Leu Ile Leu His Leu Gln Ala Arg Met Ala Gln
310 315 320ACT ACG ACA ACA AAG TGC CTT TAAATTTTAG GGTGTTTAAG CCTTATTGCT CAAG 1074Thr Thr Thr Thr Lys Cys Leu
325CGCTGATCTG TCTTCTT 1091
(2) Sequence 1162 data:
(i) sequence characteristics:
(A) length: 328 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1162: met Met Val Val Val Leu Phe Cys Val Asn Gly Ala Leu Phe Leu Ala 151015 Leu Gly Leu Ile Ser Ala Ser Leu Met Arg Trp Ser Ala Ile Val Phe
20 25 30Ser Leu Leu Asn Ser Val Ala Phe Tyr Phe Ile Ser Ala Tyr Lys Val
35 40 45Phe Leu Asn Lys Ser Met Met Gly Asn Val Leu Asn Thr Asn Thr His
50 55 60Glu Val Leu Gly Phe Leu Ser Val Lys Leu Phe Val Phe Ile Val Val65 70 75 80Phe Gly Val Leu Pro Gly Tyr Val Ile Tyr Lys Ile Pro Leu Lys Asn
85 90 95Ser Ser Lys Lys Ala Pro Phe Leu Ala Ile Leu Ala Leu Val Phe Ile
100 105 110Phe Ile Ala Ser Ala Leu Ala Asn Thr Lys Asn Trp Leu Trp Phe Asp
115 120 125Lys His Ala Lys Phe Ile Gly Gly Leu Ile Leu Pro Phe Ala Tyr Ser
130 135 140Val Asn Ala Phe Arg Val Ser Ala Leu Lys Phe Phe Ala Pro Thr Ile145 150 155 160Lys Pro Leu Pro Leu Phe Ser Pro Asn His Ser His Ser Phe Val Val
165 170 175Leu Val Ile Gly Glu Ser Ala Arg Lys His Asn Tyr Ala Leu Tyr Gly
180 185 190Tyr Gln Lys Pro Thr Thr Pro Arg Leu Ser Lys Arg Leu Ala Asp Asn
195 200 205Glu Leu Thr Leu Phe Asn Ala Thr Ser Cys Ala Thr Tyr Thr Thr Ala
210 215 220Ser Leu Glu Cys Ile Leu Asp Ser Ser Phe Lys Asn Asn Ala Tyr Glu225 230 235 240Asn Leu Pro Thr Tyr Leu Thr Lys Ala Gly Ile Lys Val Phe Trp Tyr
245 250 255Ser Ala Asn Asp Gly Glu Lys Asn Val Lys Val Thr Ser Tyr Leu Lys
260 265 270Asn Tyr Glu Leu Ile Gln Lys Cys Pro Asn Cys Glu Ala Ile Ala Pro
275 280 285Tyr Asp Glu Ser Leu Leu Tyr Asn Leu Pro Asp Leu Leu Lys Glu His
290 295 300Ser Asn Glu Asn Val Leu Leu Ile Leu His Leu Gln Ala Arg Met Ala305 310 315 320Gln Thr Thr Thr Thr Lys Cys Leu
325
(2) Sequence 1163 data:
(i) sequence characteristics:
(A) length: 1879 bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...1827
(D) Other information:
(xi) Description of the sequence: sequence 1163: AAGCTCAAAG ATAAAGCGCT ACAATCTCGC TTAGAAAAAG GACACAAA ATG CTA TTG 57
Met Leu Leu
1AAT TAC GAT TTT TTA GAA TTT GTT GAT GAG CCG AAA AGA AAC ACT TCT 105Asn Tyr Asp Phe Leu Glu Phe Val Asp Glu Pro Lys Arg Asn Thr Ser
5 10 15TTG ACA GCA TCT ATT GAT AAA GCG TTA GCG GAC AGG AAG TTA GCT AGA 153Leu Thr Ala Ser Ile Asp Lys Ala Leu Ala Asp Arg Lys Leu Ala Arg20 25 30 35CAA AAT AAA CCT AGC GTT AGG GTG CTT GGT AAG GCG ATG CCC TTA AGC 201Gln Asn Lys Pro Ser Val Arg Val Leu Gly Lys Ala Met Pro Leu Ser
40 45 50AAG TTT TTA GAT GCT GTT GGC GAT GAA ATC TCA CGA CTT AAA TAT GAT 249Lys Phe Leu Asp Ala Val Gly Asp Glu Ile Ser Arg Leu Lys Tyr Asp
55 60 65ATG AGC CAC AAG ACT ATT AAA GGC TCT ACA ATT GAG AGT TCT AAT CTT 297Met Ser His Lys Thr Ile Lys Gly Ser Thr Ile Glu Ser Ser Asn Leu
70 75 80ATC AGC ATT TAT AAA AAG ATT GCG AGC GGA CTA CCT TTT GGG ACT ATC 345Ile Ser Ile Tyr Lys Lys Ile Ala Ser Gly Leu Pro Phe Gly Thr Ile
85 90 95TCG GCG TTT AGA CCT TTT AAA GAC GCT TTT TAT AAA GAC TTT ACC GAA 393Ser Ala Phe Arg Pro Phe Lys Asp Ala Phe Tyr Lys Asp Phe Thr Glu100 105 110 115AAA GAA CAA AAC GCT CTA ATC TAT GCT TAT AAG AGC GGA GCA GAC CCT 441Lys Glu Gln Asn Ala Leu Ile Tyr Ala Tyr Lys Ser Gly Ala Asp Pro
120 125 130AAA AAT GCG GAC ATA ATA GCC AAA TAT TGG TTA AGT CAA TCT GTG GAT 489Lys Asn Ala Asp Ile Ile Ala Lys Tyr Trp Leu Ser Gln Ser Val Asp
135 140 145TTAGAC CCA TAC GAC CCT ATT AAA GTT GTA GAT TTC TTT CAC CCA CAA 537Leu Asp Pro Tyr Asp Pro Ile Lys Val Val Asp Phe Phe His Pro Gln
150 155 160CCT GAA AAT GGT AAA GAG ACT ACA AAA TTT AAG AAC TAC AAA GAT AGG 585Pro Glu Asn Gly Lys Glu Thr Thr Lys Phe Lys Asn Tyr Lys Asp Arg
165 170 175ATT GAG AAC ATT TAT GCG ACA CTC TAT AAC ACA TTG GGT AGG GGT TAT 633Ile Glu Asn Ile Tyr Ala Thr Leu Tyr Asn Thr Leu Gly Arg Gly Tyr180 185 190 195GTG GAT AAA TTT TTT AAA AAA GAA GCC ACA ATG AGG GAC TTT ATG TCT 681Val Asp Lys Phe Phe Lys Lys Glu Ala Thr Met Arg Asp Phe Met Ser
200 205 210AGC GAT AAA TTT GTT GAG AGA TAC CGC TAC ACT AGA AAA GAA AAT ATG 729Ser Asp Lys Phe Val Glu Arg Tyr Arg Tyr Thr Arg Lys Glu Asn Met
215 220 225GCA AGG ACA CAA GCA TTA AAA GAC ATA ATG AAT ATT GAC AGA GAT TTC 777Ala Arg Thr Gln Ala Leu Lys Asp Ile Met Asn Ile Asp Arg Asp Phe
230 35 240ATT GGT TAT ATT GAA GTG TTA GGG TAT TGG AAA GAC AAC CCT AAA GAC 825Ile Gly Tyr Ile Glu Val Leu Gly Tyr Trp Lys Asp Asn Pro Lys Asp
245 250 255AAT ATC TTA CCA GAC AAA GAG GTT AGC TTT TTT GTA TTC CAA AAC GAA 873Asn Ile Leu Pro Asp Lys Glu Val Ser Phe Phe Val Phe Gln Asn Glu260 265 270 275CCT AGT AGC ACA TTT GAT TTG AAA AAC CAC TTA TTG ATA TGG GGT AAA 921Pro Ser Ser Thr Phe Asp Leu Lys Asn His Leu Leu Ile Trp Gly Lys
280 285 290CAA TTC AGA CAA GTA GCG ATT TGC TAT GGC GGA CAA TTG ATT GCT AAT 969Gln Phe Arg GlnVal Ala Ile Cys Tyr Gly Gly Gln Leu Ile Ala Asn
295 300 305AAG AAT AAG ACT TAT AGG ATA GAT TTG ATA AGT TGC AGA CCT GAT AAT 1017Lys Asn Lys Thr Tyr Arg Ile Asp Leu Ile Ser Cys Arg Pro Asp Asn
310 315 320TTT GGT GAG GTT TGG GCT AAA TTC ACA GGG ATT AAA TTT TCA GTT CCT 1065Phe Gly Glu Val Trp Ala Lys Phe Thr Gly Ile Lys Phe Ser Val Pro
325 330 335AGC GAC TTA CCA CAA GCT CTC ACA CGC ATA AAT GAC AGC GTT TAT ACT 1113Ser Asp Leu Pro Gln Ala Leu Thr Arg Ile Asn Asp Ser Val Tyr Thr340 345 350 355TTT CTC TCT AGG AAT AAA GAG GGT ATC GGT CTT AAT AAA CTC GCT CTC 1161Phe Leu Ser Arg Asn Lys Glu Gly Ile Gly Leu Asn Lys Leu Ala Leu
360 365 370AAT AAA GTC GTT AAG ACA GAA TTA AAA GCG ACT TGT ATG CCC TAT GAT 1209Asn Lys Val Val Lys Thr Glu Leu Lys Ala Thr Cys Met Pro Tyr Asp
375 380 385TAC TCT AAA TTG GGT ATA GAG ACT ATT GGC GAG GAC ATT AGA AGC AAT 1257Tyr Ser Lys Leu Gly Ile Glu Thr Ile Gly Glu Asp Ile Arg Ser Asn
390 395 400ATT AAA GCA TTA CAG AAA ATG TCT CGT GGG TAT GGA CAC CCT AAA GAG 1305Ile Lys Ala Leu Gln Lys Met Ser Arg Gly Tyr Gly His Pro Lys Glu
405 410 415TTC TTT TTG GAC GCA ATG ATA AAA AAA CAG GAA AAT GCG ATT AAA CGC 1353Phe Phe Leu Asp Ala Met Ile Lys Lys Gln Glu Asn Ala Ile Lys Arg420 425 430 435ATA GAA GCA CGA AAA TGT GCG GTA AGC GAT GAC TTC AAA CAA GGT ATG 1401Ile Glu Ala Arg Lys Cys Ala Val Ser Asp Asp Phe Lys Gln Gly Met
440 445 450AAA CGA AAC ATT AAA GTT AAT AAC CTT GTT AAA GCT ATG CGA CAA GGC 1449Lys Arg Asn Ile Lys Val Asn Asn Leu Val Lys Ala Met Arg Gln Gly
455 460 465AAA AAA GTG AGT AGG ACA TTG ATT GCT AAA GTG CTT GCT AAC ACC ATA 1497Lys Lys Val Ser Arg Thr Leu Ile Ala Lys Val Leu Ala Asn Thr Ile
470 475 480GAC ACC GAT GCG GGT TAT TGC TTC ATT TCG CCG ACA GAT TTA GCG ACA 1545Asp Thr Asp Ala Gly Tyr Cys Phe Ile Ser Pro Thr Asp Leu Ala Thr
485 490 495CAA CTT GGC AAC ATC AGC CCT AGA CTA TCT AAA AGC ATA GTT ACC GCC 1593Gln Leu Gly Asn Ile Ser Pro Arg Leu Ser Lys Ser Ile Val Thr Ala500 505 510 515ATA GAG CAA GCA GAG GGC GTG AGA CTG AAT TAT GCG TTG ATT GAC AAA 1641Ile Glu Gln Ala Glu Gly Val Arg Leu Asn Tyr Ala Leu Ile Asp Lys
520 525 530ATC ACC TAT AAC TCA CTC CAC AAT ATC TTA AGT TTC ATT TTT GAT ATT 1689Ile Thr Tyr Asn Ser Leu His Asn Ile Leu Ser Phe Ile Phe Asp Ile
535 540 545GAT AAC CCT TTA AGC GAC CAA GTG TTT GAG AGA TTA GTC ATT GAA GTC 1737Asp Asn Pro Leu Ser Asp Gln Val Phe Glu Arg Leu Val Ile Glu Val
550 555 560CCA AGA GAA GCA CTT AAA AAT GTG AAG TTG CCA CAA ATC AAA AAT GTA 1785Pro Arg Glu Ala Leu Lys Asn Val Lys Leu Pro Gln Ile Lys Asn Val
565 570 575TTG ACT TCT CAA ATC TTT GAT GGC GCT TAC CAC TTT AAA AGT TAAACCATG 1836Leu Thr Ser Gln Ile Phe Asp Gly Ala Tyr His Phe Lys Ser580 585 590CTCTTTATCA GCGCAACTAA CACGAATGCC GGAAAAACCA CAT1879
(2) Sequence 1164 data:
(i) sequence characteristics:
(A) length: 593 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1164: met Leu Leu Asn Tyr Asp Phe Leu Glu Phe Val Asp Glu Pro Lys Arg 151015 Asn Thr Ser Leu Thr Ala Ser Ile Asp Lys Ala Leu Ala Asp Arg Lys
20 25 30Leu Ala Arg Gln Asn Lys Pro Ser Val Arg Val Leu Gly Lys Ala Met
35 40 45Pro Leu Ser Lys Phe Leu Asp Ala Val Gly Asp Glu Ile Ser Arg Leu
50 55 60Lys Tyr Asp Met Ser His Lys Thr Ile Lys Gly Ser Thr Ile Glu Ser65 70 75 80Ser Asn Leu Ile Ser Ile Tyr Lys Lys Ile Ala Ser Gly Leu Pro Phe
85 90 95Gly Thr Ile Ser Ala Phe Arg Pro Phe Lys Asp Ala Phe Tyr Lys Asp
100 105 110Phe Thr Glu Lys Glu Gln Asn Ala Leu Ile Tyr Ala Tyr Lys Ser Gly
115 120 125Ala Asp Pro Lys Asn Ala Asp Ile Ile Ala Lys Tyr Trp Leu Ser Gln
130 135 140Ser Val Asp Leu Asp Pro Tyr Asp Pro Ile Lys Val Val Asp Phe Phe145 150 155 160His Pro Gln Pro Glu Asn Gly Lys Glu Thr Thr Lys Phe Lys Asn Tyr
165170 175Lys Asp Arg Ile Glu Asn Ile Tyr Ala Thr Leu Tyr Asn Thr Leu Gly
180 185 190Arg Gly Tyr Val Asp Lys Phe Phe Lys Lys Glu Ala Thr Met Arg Asp
195 200 205Phe Met Ser Ser Asp Lys Phe Val Glu Arg Tyr Arg Tyr Thr Arg Lys
210 215 220Glu Asn Met Ala Arg Thr Gln Ala Leu Lys Asp Ile Met Asn Ile Asp225 230 235 240Arg Asp Phe Ile Gly Tyr Ile Glu Val Leu Gly Tyr Trp Lys Asp Asn
245 250 255Pro Lys Asp Asn Ile Leu Pro Asp Lys Glu Val Ser Phe Phe Val Phe
260 265 270Gln Asn Glu Pro Ser Ser Thr Phe Asp Leu Lys Asn His Leu Leu Ile
275 280 285Trp Gly Lys Gln Phe Arg Gln Val Ala Ile Cys Tyr Gly Gly Gln Leu
290 295 300Ile Ala Asn Lys Asn Lys Thr Tyr Arg Ile Asp Leu Ile Ser Cys Arg305 310 315 320Pro Asp Asn Phe Gly Glu Val Trp Ala Lys Phe Thr Gly Ile Lys Phe
325 330 335Ser Val Pro Ser Asp Leu Pro Gln Ala Leu Thr Arg Ile Asn Asp Ser
340 345 350Val Tyr Thr Phe Leu Ser Arg Asn Lys Glu Gly Ile Gly Leu Asn Lys
355 360 365Leu Ala Leu Asn Lys Val Val Lys Thr Glu Leu Lys Ala Thr Cys Met
370 375 380Pro Tyr Asp Tyr Ser Lys Leu Gly Ile Glu Thr Ile Gly Glu Asp Ile385 390395 400Arg Ser Asn Ile Lys Ala Leu Gln Lys Met Ser Arg Gly Tyr Gly His
405 410 415Pro Lys Glu Phe Phe Leu Asp Ala Met Ile Lys Lys Gln Glu Asn Ala
420 425 430Ile Lys Arg Ile Glu Ala Arg Lys Cys Ala Val Ser Asp Asp Phe Lys
435 440 445Gln Gly Met Lys Arg Asn Ile Lys Val Asn Asn Leu Val Lys Ala Met
450 455 460Arg Gln Gly Lys Lys Val Ser Arg Thr Leu Ile Ala Lys Val Leu Ala465 470 475 480Asn Thr Ile Asp Thr Asp Ala Gly Tyr Cys Phe Ile Ser Pro Thr Asp
485 490 495Leu Ala Thr Gln Leu Gly Asn Ile Ser Pro Arg Leu Ser Lys Ser Ile
500 505 510ValThr Ala Ile Glu Gln Ala Glu Gly Val Arg Leu Asn Tyr Ala Leu
515 520 525Ile Asp Lys Ile Thr Tyr Asn Ser Leu His Asn Ile Leu Ser Phe Ile
530 535 540Phe Asp Ile Asp Asn Pro Leu Ser Asp Gln Val Phe Glu Arg Leu Val545 550 555 560Ile Glu Val Pro Arg Glu Ala Leu Lys Asn Val Lys Leu Pro Gln Ile
565 570 575Lys Asn Val Leu Thr Ser Gln Ile Phe Asp Gly Ala Tyr His Phe Lys
580 585 590Ser
(2) Sequence 1165 data:
(i) sequence characteristics:
(A) length: 1063 bp
(B) Type(2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 13...1014
(D) Other information:
(xi) Description of the sequence: sequence 1165: TGCTAAATTG TG ATG TTT CAC AAA GCC CTT ATT ACC TTT ATC GTT CTA TGG 51
Met Phe His Lys Ala Leu Ile Thr Phe Ile Val Leu Trp
1 5 10TTT TTT TTG AAT GGC TTA GGG GCT TAT GAT TTC AAG CAT TGT CAA GCG 99Phe Phe Leu Asn Gly Leu Gly Ala Tyr Asp Phe Lys His Cys Gln Ala
15 20 25TTT TTT AAA AAA GCG AGC CTT CAA AAA GGA GGC GTG GCT TTA AAA GAA 147Phe Phe Lys Lys Ala Ser Leu Gln Lys Gly Gly Val Ala Leu Lys Glu30 35 40 45TTG CCT AAA GGC GTG TAT TTG TAT TAT TCC AAA ACC TAT CCC AAA CAC 195Leu Pro Lys Gly Val Tyr Leu Tyr Tyr Ser Lys Thr Tyr Pro Lys His
50 55 60GCC AAA GTC ATC AAA TCC GAT CCC TTT GTA GGG TTG TAT TTG TTG CAA 243Ala Lys Val Ile Lys Ser Asp Pro Phe Val Gly Leu Tyr Leu Leu Gln
65 70 75AGC GCA CCA AGC GAG TAT GTT TAT ACC TTA AGG GAT TTA GAC AAA GAC 291Ser Ala Pro Ser Glu Tyr Val Tyr Thr Leu Arg Asp Leu Asp Lys Asp
80 85 90GCC CTT ATA AGG CCA ATG GCT AGC ATA GGG GAT AAA GAA GCC CTA GAA 339Ala Leu Ile Arg Pro Met Ala Ser Ile Gly Asp Lys Glu Ala Leu Glu
95 100 105ACG CGA TTA TTG GTG GGG CAA AGA GGC TAT GAG CGC TAC GCT CAA ATT 387Thr Arg Leu Leu Val Gly Gln Arg Gly Tyr Glu Arg Tyr Ala Gln Ile110 115 120 125TCG CAA AAG ACT CAA AAA AAT GGC GTT ATC AGC AAT ATT TGC TAT CAA 435Ser Gln Lys Thr Gln Lys Asn Gly Val Ile Ser Asn Ile Cys Tyr Gln
130 135 140ATG TTA GGG CTA GGG GTA GGG GGG AAT GGC TTT ATA GAA ACG AAA TTT 483Met Leu Gly Leu Gly Val Gly Gly Asn Gly Phe Ile Glu Thr Lys Phe
145 150 155ATC AAG CGC TTT TTA AAC CAG CAA GAG CCT TAT TAT GGG GAT ATT GGG 531Ile Lys Arg Phe Leu Asn Gln Gln Glu Pro Tyr Tyr Gly Asp Ile Gly
160 165 170GTG CGT TTA GAA GAA CAT CAT AAG CGT TTA GTG GTA GTG CAA TTT GAT 579Val Arg Leu Glu Glu His His Lys Arg Leu Val Val Val Gln Phe Asp
175 180 185CCA TTT TTC CCT AAA AAC CCT TTT TTA AAA AAC GAT GAA ATC CTA GCG 627Pro Phe Phe Pro Lys Asn Pro Phe Leu Lys Asn Asp Glu Ile Leu Ala190 195 200 205ATC AAC CAT CAA AAG ATC CAC TCA TTA GCG GAG TTT GAA TGG GTG GTG 675Ile Asn His Gln Lys Ile His Ser Leu Ala Glu Phe Glu Trp Val Val
210 215 220AGC AAT CTT AAA TAC CAA AGC CTT GCA AAA GTG GAA ATC AAA CGA AAC 723Ser Asn Leu Lys Tyr Gln Ser Leu Ala Lys Val Glu Ile Lys Arg Asn
225 230 235CAT AAA GTC AAA GAA GTA ACG CTC AAA GTC AAT AAG CGT TAT GGG GGG 771His Lys Val Lys Glu Val Thr Leu Lys Val Asn Lys Arg Tyr Gly Gly
240 245 250TTT TTA CTC AAA GAC ACT TTT TTA GAG CGC TAT GGC ATC GCT TTA GAT 819Phe Leu Leu Lys Asp Thr Phe Leu Glu Arg Tyr Gly Ile Ala Leu Asp
255 260 265GAG CGT TTT ATT ATC ACT AAA ATA GGC GCT CAT TTG CCC AAA GGC TTG 867Glu Arg Phe Ile Ile Thr Lys Ile Gly Ala His Leu Pro Lys Gly Leu270 275 280 285GAT TTT TTA AAG CTT GGG GAT AGG ATT TTA TGG GTG AAT TAT AAA AGC 915Asp Phe Leu Lys Leu Gly Asp Arg Ile Leu Trp Val Asn Tyr Lys Ser
290 295 300GTG GCG TCC AAC CCA AAG GCT TTA AGA GAA GCG TTA AGC GCG CCT AAA 963Val Ala Ser Asn Pro Lys Ala Leu Arg Glu Ala Leu Ser Ala Pro Lys
305 310 315ATT GAA TTA TTA GTC TTG CGT AAA GGC TTT GAA TTT TAC ATT AAA GTC 1011Ile Glu Leu Leu Val Leu Arg Lys Gly Phe Glu Phe Tyr Ile Lys Val
320 325 330CGT TGAAGTATTG ATGAAAAATG ACGCTTATGA AATTATTCTT TCTTGGTTT 1063Arg
(2) Sequence 1166 data:
(i) sequence characteristics:
(A) length: 334 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1166: met Phe His Lys Ala Leu Ile Thr Phe Ile Val Leu Trp Phe Phe Leu 15l 015 Asn Gly Leu Gly Ala Tyr Asp Phe Lys His Cys Gln Ala Phe Phe Lys
20 25 30Lys Ala Ser Leu Gln Lys Gly Gly Val Ala Leu Lys Glu Leu Pro Lys
35 40 45Gly Val Tyr Leu Tyr Tyr Ser Lys Thr Tyr Pro Lys His Ala Lys Val
50 55 60Ile Lys Ser Asp Pro Phe Val Gly Leu Tyr Leu Leu Gln Ser Ala Pro65 70 75 80Ser Glu Tyr Val Tyr Thr Leu Arg Asp Leu Asp Lys Asp Ala Leu Ile
85 90 95Arg Pro Met Ala Ser Ile Gly Asp Lys Glu Ala Leu Glu Thr Arg Leu
100 105 110Leu Val Gly Gln Arg Gly Tyr Glu Arg Tyr Ala Gln Ile Ser Gln Lys
115 120 125Thr Gln Lys Asn Gly Val Ile Ser Asn Ile Cys Tyr Gln Met Leu Gly
130 135 140Leu Gly Val Gly Gly Asn Gly Phe Ile Glu Thr Lys Phe Ile Lys Arg145 150 155 160Phe Leu Asn Gln Gln Glu Pro Tyr Tyr Gly Asp Ile Gly Val Arg Leu
165 170 175Glu Glu His His Lys Arg Leu Val Val Val Gln Phe Asp Pro Phe Phe
180 185 190Pro Lys Asn Pro Phe Leu Lys Asn Asp Glu Ile Leu Ala Ile Asn His
195 200 205Gln Lys Ile His Ser Leu Ala Glu Phe Glu Trp Val Val Ser Asn Leu
210 215 220Lys Tyr Gln Ser Leu Ala Lys Val Glu Ile Lys Arg Asn His Lys Val225 230 235 240Lys Glu Val Thr Leu Lys Val Asn Lys Arg Tyr Gly Gly Phe Leu Leu
245 250 255Lys Asp Thr Phe Leu Glu Arg Tyr Gly Ile Ala Leu Asp Glu Arg Phe
260 265 270Ile Ile Thr Lys Ile Gly Ala His Leu Pro Lys Gly Leu Asp Phe Leu
275 280 285Lys Leu Gly Asp Arg Ile Leu Trp Val Asn Tyr Lys Ser Val Ala Ser
290 295 300Asn Pro Lys Ala Leu Arg Glu Ala Leu Ser Ala Pro Lys Ile Glu Leu305 310 315 320Leu Val Leu Arg Lys Gly Phe Glu Phe Tyr Ile Lys Val Arg
325 330
(2) Sequence 1167 data:
(i) sequence characteristics:
(A) length: 1133 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...1104
(D) Other information:
(xi) Description of the sequence: sequence 1167: TAGTCTTGCG TAAAGGCTTT GAATTTTACA TTAAAGTCCG TTGAAGTATT G ATG AAA 57
Met Lys
1AAT GAC GCT TAT GAA ATT ATT CTT TCT TGG TTT ATC ACG CCT CTC ACG 105Asn Asp Ala Tyr Glu Ile Ile Leu Ser Trp Phe Ile Thr Pro Leu Thr
5 10 15GCG ATT TTA GGG CGT TTC GCT GAA TTT TTT CTC TAC ACT TTG CAT GCG 153Ala Ile Leu Gly Arg Phe Ala Glu Phe Phe Leu Tyr Thr Leu His Ala
20 25 30CAA TTG GTG TTT AAT AGC GTG GTC GCT TTG GCG TTC ATG CTC TTT GCT 201Gln Leu Val Phe Asn Ser Val Val Ala Leu Ala Phe Met Leu Phe Ala35 40 45 50TAT AGG AGT TTG AAA GAA CAG AAT TTC TTC AGC GCT AGC GCG CTA ACA 249Tyr Arg Ser Leu Lys Glu Gln Asn Phe Phe Ser Ala Ser Ala Leu Thr
55 60 65GAA GCG TTA TTG TTT GTG GGG TTT TTT GCA CTT TTC AAC TAC GCT TTA 297Glu Ala Leu Leu Phe Val Gly Phe Phe Ala Leu Phe Asn Tyr Ala Leu
70 75 80AAA AAT CCC ATG CAT TTT TAT GAA TTT TTC CAA AAC GCT ATT TTT ATT 345Lys Asn Pro Met His Phe Tyr Glu Phe Phe Gln Asn Ala Ile Phe Ile
85 90 95GCG CCT AAC ATG ATC GCG CAA AGC CTC TCT CAA AGC TTG AGT AAC TTT 393Ala Pro Asn Met Ile Ala Gln Ser Leu Ser Gln Ser Leu Ser Asn Phe
100 105 110TCT GAC CAT GCG CTT TCT TTA GAT TTT ATC TTT AAT CAT GGT TTT TAT 441Ser Asp His Ala Leu Ser Leu Asp Phe Ile Phe Asn His Gly Phe Tyr115 120 125 130GCC CTT AGT TTC ATC AGC GAT TTG AGC CAT AAT GAA ATG TCT GTG TGG 489Ala Leu Ser Phe Ile Ser Asp Leu Ser His Asn Glu Met Ser Val Trp
135 140 145CTT TTT TTA AGC GTT TTG CAA GGG CTT TTT TTG AGC GTG CTG TTT GCA 537Leu Phe Leu Ser Val Leu Gln Gly Leu Phe Leu Ser Val Leu Phe Ala
150 155 160ATC ATC ATT TTA GTG TAT TTA GAA GTG CAT GTG TGG TGC TCT TTA GGG 585Ile Ile Ile Leu Val Tyr Leu Glu Val His Val Trp Cys Ser Leu Gly
165 170 175GTG CTG TTT TTA GCG TTT GGG TTT TTT AAA ACC TGG AGG AGC GTT GTG 633Val Leu Phe Leu Ala Phe Gly Phe Phe Lys Thr Trp Arg Ser Val Val
180 185 190GTT ATA TGC CTA AAA AAG TGC TTC GCT CTT GGG TTT TAC AAG CCT TTT 681Val Ile Cys Leu Lys Lys Cys Phe Ala Leu Gly Phe Tyr Lys Pro Phe195 200 205 210TTG TTG TTG GTA GGG TTT TTG AAT GTG TCG GTT ACT AAG GCT TTA ATA 729Leu Leu Leu Val Gly Phe Leu Asn Val Ser Val Thr Lys Ala Leu Ile
215 220 225GAC GCT CAT ATG CAA GAA AAA CAA GAC TTA AGC CTT TTA TTG GTG GTA 777Asp Ala His Met Gln Glu Lys Gln Asp Leu Ser Leu Leu Leu Val Val
230 235 240GCG TTA TTT TTG TGT TGC GTT TTT ATC ATC GGC GTG CCT TTT TTC ATC 825Ala Leu Phe Leu Cys Cys Val Phe Ile Ile Gly Val Pro Phe Phe Ile
245 250 255AAC GCT TTG TTT AGG GTG CAA AAC AGC CTT AAA GAA ACT TAC AAA CTC 873Asn Ala Leu Phe Arg Val Gln Asn Ser Leu Lys Glu Thr Tyr Lys Leu
260 265 270GCC ACC AAT TTG AGT GCC AAC CTC AGC CAA AAC GCC CTT AAT TCC TTA 921Ala Thr Asn Leu Ser Ala Asn Leu Ser Gln Asn Ala Leu Asn Ser Leu275 280 285 290CAA TAC ATC ACG ACC CCA CCC GCT TCT TCT AGC GTT TCT TCT TCT ATG 969Gln Tyr Ile Thr Thr Pro Pro Ala Ser Ser Ser Val Ser Ser Ser Met
295 300 305AGT GAA AGC GTC TCT AAA GAA AAA GAA ACG CAT TCC CCC ACA TTT AAG 1017Ser Glu Ser Val Ser Lys Glu Lys Glu Thr His Ser Pro Thr Phe Lys
310 315 320GTA GAA ACC ACT CAA TTA GAT GTA AAA ATC CCA AAT TTC AAG CAA AAA 1065Val Glu Thr Thr Gln Leu Asp Val Lys Ile Pro Asn Phe Lys Gln Lys
325 330 335AAG GTT AAA AAG GAT ACA ATA AAT ACA AAA AAT GAA ATT TAAATAAATA GG 1116Lys Val Lys Lys Asp Thr Ile Asn Thr Lys Asn Glu Ile
340 345 350AATTTAATGA GAATTTT 1133
(2) Sequence 1168 data:
(i) sequence characteristics:
(A) length: 351 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1168: met Lys Asn Asp Ala Tyr Glu Ile Ile Leu Ser Trp Phe Ile Thr Pro 151015 Leu Thr Ala Ile Leu Gly Arg Phe Ala Glu Phe Phe Leu Tyr Thr Leu
20 25 30His Ala Gln Leu Val Phe Asn Ser Val Val Ala Leu Ala Phe Met Leu
35 40 45Phe Ala Tyr Arg Ser Leu Lys Glu Gln Asn Phe Phe Ser Ala Ser Ala
50 55 60Leu Thr Glu Ala Leu Leu Phe Val Gly Phe Phe Ala Leu Phe Asn Tyr65 70 75 80Ala Leu Lys Asn Pro Met His Phe Tyr Glu Phe Phe Gln Asn Ala Ile
85 90 95Phe Ile Ala Pro Asn Met Ile Ala Gln Ser Leu Ser Gln Ser Leu Ser
100 105 110Asn Phe Ser Asp His Ala Leu Ser Leu Asp Phe Ile Phe Asn His Gly
115120 125Phe Tyr Ala Leu Ser Phe Ile Ser Asp Leu Ser His Asn Glu Met Ser
130 135 140Val Trp Leu Phe Leu Ser Val Leu Gln Gly Leu Phe Leu Ser Val Leu145 150 155 160Phe Ala Ile Ile Ile Leu Val Tyr Leu Glu Val His Val Trp Cys Ser
165 170 175Leu Gly Val Leu Phe Leu Ala Phe Gly Phe Phe Lys Thr Trp Arg Ser
180 185 190Val Val Val Ile Cys Leu Lys Lys Cys Phe Ala Leu Gly Phe Tyr Lys
195 200 205Pro Phe Leu Leu Leu Val Gly Phe Leu Asn Val Ser Val Thr Lys Ala
210 215 220Leu Ile Asp Ala His Met Gln Glu Lys Gln Asp Leu Ser Leu Leu Leu225 230 235 240Val Val Ala Leu Phe Leu Cys Cys Val Phe Ile Ile Gly Val Pro Phe
245 250 255Phe Ile Asn Ala Leu Phe Arg Val Gln Asn Ser Leu Lys Glu Thr Tyr
260 265 270Lys Leu Ala Thr Asn Leu Ser Ala Asn Leu Ser Gln Asn Ala Leu Asn
275 280 285Ser Leu Gln Tyr Ile Thr Thr Pro Pro Ala Ser Ser Ser Val Ser Ser
290 295 300Ser Met Ser Glu Ser Val Ser Lys Glu Lys Glu Thr His Ser Pro Thr305 310 315 320Phe Lys Val Glu Thr Thr Gln Leu Asp Val Lys Ile Pro Asn Phe Lys
325 330 335Gln Lys Lys Val Lys Lys Asp Thr Ile Asn Thr Lys Asn Glu Ile
340 345350
(2) Sequence 1169 data:
(i) sequence characteristics:
(A) length: 777 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...748
(D) Other information:
(xi) Description of the sequence: sequence 1169: CCCTTTCAAA CAAGGCCCTA AAAATTACGA AGAAAACCTG ATTTTCCCC ATG GAT AAC 58
Met Asp Asn
1CCT AAA GGC ATT GAT GGT TTT ACT AAC CTT AAA GAA AAA GAC ATC GCC 106Pro Lys Gly Ile Asp Gly Phe Thr Asn Leu Lys Glu Lys Asp Ile Ala
5 10 15ACT AAT GAA AAT AAG CTT TTA CGC ACC ATT ACA GCG GAT AAA ATG ATA 154Thr Asn Glu Asn Lys Leu Leu Arg Thr Ile Thr Ala Asp Lys Met Ile20 25 30 35CCC GCC TTT CTC ATC ACG CCT ATT TCT AGC CAG ATC GCT GGT AAA GTC 202Pro Ala Phe Leu Ile Thr Pro Ile Ser Ser Gln Ile Ala Gly Lys Val
40 45 50ATC GCG CAG GTG GAG AGC GAT ATT TTT GCT CAC ATG GGC AAG GCC GTC 250Ile Ala Gln Val Glu Ser Asp Ile Phe Ala His Met Gly Lys Ala Val
55 60 65TTA ATC CCC AAA GGC TCT AAA GTC ATA GGT TAT TAC AGC AAC AAT AAC 298Leu Ile Pro Lys Gly Ser Lys Val Ile Gly Tyr Tyr Ser Asn Asn Asn
70 75 80AAA ATG GGC GAA TAC CGC TTG GAT ATT GTA TGG AGC CGC ATC ATC ACT 346Lys Met Gly Glu Tyr Arg Leu Asp Ile Val Trp Ser Arg Ile Ile Thr
85 90 95CCC CAT GGC ATC AAT ATC ATG CTC ACT AAC GCT AAA GGG GCG GAC ATT 394Pro His Gly Ile Asn Ile Met Leu Thr Asn Ala Lys Gly Ala Asp Ile100 105 110 115AAA GGC TAT AAC GGC TTG GTG GGG GAA TTG ATT GAA AGG AAT TTC CAG 442Lys Gly Tyr Asn Gly Leu Val Gly Glu Leu Ile Glu Arg Asn Phe Gln
120 125 130CGC TAT GGC GTG CCG TTA CTG CTT TCT ACT CTC ACT AAC GGC CTA TTG 490Arg Tyr Gly Val Pro Leu Leu Leu Ser Thr Leu Thr Asn Gly Leu Leu
135 140 145ATT GGG ATC ACT TCG GCT TTA AAC AAC AGA GGC AAT AAA GAA GGA GCC 538Ile Gly Ile Thr Ser Ala Leu Asn Asn Arg Gly Asn Lys Glu Gly Ala
150 155 160ACC AAT TTC TTT GGG GAT TAT CTT TTA ATG CAA TTG ATG AGG CAA AGC 586Thr Asn Phe Phe Gly Asp Tyr Leu Leu Met Gln Leu Met Arg Gln Ser
165 170 175GGC ATG GGG ATC AAT CAA GTA GTC AAT CAA ATT TTA AGA GAT AAG AGC 634Gly Met Gly Ile Asn Gln Val Val Asn Gln Ile Leu Arg Asp Lys Ser180 185 190 195AAA ATC GCT CCT ATT GTG GTG ATT AGA GAA GGG AGT AGG GTC TTC ATT 682Lys Ile Ala Pro Ile Val Val Ile Arg Glu Gly Ser Arg Val Phe Ile
200 205 210TCG CCC AAT ACT GAC ATC TTT TTC CCT ATA CCC AGA GAG AAT GAA GTC 730Ser Pro Asn Thr Asp Ile Phe Phe Pro Ile Pro Arg Glu Asn Glu Val
215 220 225ATC GCT GAG ITT TTG AAG TGACTCAAAA ATCCCCAATT AAAAACGCT 777Ile Ala Glu Phe Leu Lys
230
(2) Sequence 1170 data:
(i) sequence characteristics:
(A) length: 233 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1170: met Asp Asn Pro Lys Gly Ile Asp Gly Phe Thr Asn Leu Lys Glu Lys 151015 Asp Ile Ala Thr Asn Glu Asn Lys Leu Leu Arg Thr Ile Thr Ala Asp
20 25 30Lys Met Ile Pro Ala Phe Leu Ile Thr Pro Ile Ser Ser Gln Ile Ala
35 40 45Gly Lys Val Ile Ala Gln Val Glu Ser Asp Ile Phe Ala His Met Gly
50 55 60Lys Ala Val Leu Ile Pro Lys Gly Ser Lys Val Ile Gly Tyr Tyr Ser65 70 75 80Asn Asn Asn Lys Met Gly Glu Tyr Arg Leu Asp Ile Val Trp Ser Arg
85 90 95Ile Ile Thr Pro His Gly Ile Asn Ile Met Leu Thr Asn Ala Lys Gly
100 105 110Ala Asp Ile Lys Gly Tyr Asn Gly Leu Val Gly Glu Leu Ile Glu Arg
115 120 125Asn Phe Gln Arg Tyr Gly Val Pro Leu Leu Leu Ser Thr Leu Thr Asn
130 135 140Gly Leu Leu Ile Gly Ile Thr Ser Ala Leu Asn Asn Arg Gly Asn Lys145 150 155 160Glu Gly Ala Thr Asn Phe Phe Gly Asp Tyr Leu Leu Met Gln Leu Met
165 170 175Arg Gln Ser Gly Met Gly Ile Asn Gln Val Val Asn Gln Ile Leu Arg
180 185 190Asp Lys Ser Lys Ile Ala Pro Ile Val Val Ile Arg Glu Gly Ser Arg
195 200 205Val Phe Ile Ser Pro Asn Thr Asp Ile Phe Phe Pro Ile Pro Arg Glu
210 215 220Asn Glu Val Ile Ala Glu Phe Leu Lys225 230
(2) Data for sequence 1171:
(i) sequence characteristics:
(A) length: 1229 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 27...1169
(D) Other information:
(xi) Description of the sequence: sequence 1171: AAATAAAATT CAATAAAGGA AAAATA ATG AAA GAA AAA ATC GCT TTA ATC ACC 53
Met Lys Glu Lys Ile Ala Leu Ile Thr
1 5GGG GTT ACC GGG CAA GAC GGG AGC TAT CTG GCT GAA TAC TTG CTG AAT 101Gly Val Thr Gly Gln Asp Gly Ser Tyr Leu Ala Glu Tyr Leu Leu Asn10 15 20 25TTG GGT TAT GAA GTG CAT GGG TTA AAA AGG CGC TCT TCT AGC ATC AAC 149Leu Gly Tyr Glu Val His Gly Leu Lys Arg Arg Ser Ser Ser Ile Asn
30 35 40ACT TCT AGG ATC GAT CAT CTG TAT GAA GAT TTG CAT AGC GAT CAT AAA 197Thr Ser Arg Ile Asp His Leu Tyr Glu Asp Leu His Ser Asp His Lys
45 50 55AGG CGT TTT TTC TTA CAC TAT GGG GAT ATG ACC GAT AGC TCT AAT CTT 245Arg Arg Phe Phe Leu His Tyr Gly Asp Met Thr Asp Ser Ser Asn Leu
60 65 70ATC CAT TTA ATC GCT ACC ACT AAG CCT ACA GAG ATT TAT AAT TTA GCC 293Ile His Leu Ile Ala Thr Thr Lys Pro Thr Glu Ile Tyr Asn Leu Ala
75 80 85GCT CAA AGC CAT GTA AAA GTC TCT TTT GAA ACC CCC GAA TAC ACC GCT 341Ala Gln Ser His Val Lys Val Ser Phe Glu Thr Pro Glu Tyr Thr Ala90 95 100 105AAC GCT GAT GGT ATT GGC ACG CTA AGG ATT TTA GAA GCC ATG CGG ATT 389Asn Ala Asp Gly Ile Gly Thr Leu Arg Ile Leu Glu Ala Met Arg Ile
110 115 120TTA GGA TTA GAA AAG AAA ACG CGC TTT TAT CAA GCC AGC ACG AGC GAA 437Leu Gly Leu Glu Lys Lys Thr Arg Phe Tyr Gln Ala Ser Thr Ser Glu
125 130 135TTG TAT GGC GAA GTC TTA GAA ACC CCG CAA AAT GAA AAC ACC CCC TTT 485Leu Tyr Gly Glu Val Leu Glu Thr Pro Gln Asn Glu Asn Thr Pro Phe
140 145 150AAC CCA CGA AGC CCC TAT GCG GTC GCT AAA ATG TAT GCC TTT TAC ATC 533Asn Pro Arg Ser Pro Tyr Ala Val Ala Lys Met Tyr Ala Phe Tyr Ile
155 160 165ACC AAA AAT TAC AGA GAG GCC TAT AAC TTG TTT GCG GTT AAT GGC ATT 581Thr Lys Asn Tyr Arg Glu Ala Tyr Asn Leu Phe Ala Val Asn Gly Ile170 175 180 185CTT TTT AAC CAT GAG AGC AGG GTA AGG GGC GAA ACT TTT GTA ACC CGT 629Leu Phe Asn His Glu Ser Arg Val Arg Gly Glu Thr Phe Val Thr Arg
190 195 200AAA ATC ACA CGA GCC GCT AGC GCG ATA GCG TAT AAC TTA ACG GAT TGC 677Lys Ile Thr Arg Ala Ala Ser Ala Ile Ala Tyr Asn Leu Thr Asp Cys
205 210 215TTG TAT TTA GGG AAT TTA GAC GCT AAA AGA GAC TGG GGG CAT GCC AAA 725Leu Tyr Leu Gly Asn Leu Asp Ala Lys Arg Asp Trp Gly His Ala Lys
220 225 230GAT TAC GTG AAA ATG ATG CAT TTA ATG CTC CAA GCG CCC ATC CCA CAA 773Asp Tyr Val Lys Met Met His Leu Met Leu Gln Ala Pro Ile Pro Gln
235 240 245GAT TAT GTG ATC GCC ACA GGA AAG ACC ACA AGC GTG CGC GAT TTT GTG 821Asp Tyr Val Ile Ala Thr Gly Lys Thr Thr Ser Val Arg Asp Phe Val250 255 260 265AAA ATG AGC TTT GAA TTT ATC GGT ATC AAT TTA GAA TTT CAA AAT ACA 869Lys Met Ser Phe Glu Phe Ile Gly Ile Asn Leu Glu Phe Gln Asn Thr
270 275 280GGG ATT AAA GAA ATC GGT TTG ATT AAA AGC GTT GAT GAA AAA AGA GCG 917Gly Ile Lys Glu Ile Gly Leu Ile Lys Ser Val Asp Glu Lys Arg Ala
285 290 295AAC GCT TTA AAA TTG AAC TTA AGC CAT TTA AAA AAA GGC CAA ATC GTG 965Asn Ala Leu Lys Leu Asn Leu Ser His Leu Lys Lys Gly Gln Ile Val
300 305 310GTG CGC ATA GAC GAG CGT TAT TTC AGG CCT ACC GAA GTG GAT TTG CTT 1013Val Arg Ile Asp Glu Arg Tyr Phe Arg Pro Thr Glu Val Asp Leu Leu
315320 325TTA GGC GAT CCC ACT AAG GCA GAG AAA GAG CTA GAC TGG GTT AGG GAA 1061Leu Gly Asp Pro Thr Lys Ala Glu Lys Glu Leu Asp Trp Val Arg Glu330 335 340 345TAC GAT TTA AAA GAG TTG GTT AAG GAC ATG TTA GAA TAC GAT TTA AAA 1109Tyr Asp Leu Lys Glu Leu Val Lys Asp Met Leu Glu Tyr Asp Leu Lys
350 355 350GAA TGC CAA AAA AAC CTT TAC TTG CAA GAT GGG GGT TAT ATT TTA AGG 1157Glu Cys Gln Lys Asn Leu Tyr Leu Gln Asp Gly Gly Tyr Ile Leu Arg
365 370 375AAT TTT TAT GAA TGAGATTATT TTAATCACTG GTGCCTATGG CATGGTGGGG CAGAA 1214Asn Phe Tyr Glu
380CACGGCGTTG TATTT 1229
(2) Data for sequence 1172:
(i) sequence characteristics:
(A) length: 381 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1172: met Lys Glu Lys Ile Ala Leu Ile Thr Gly Val Thr Gly Gln Asp Gly 151015 Ser Tyr Leu Ala Glu Tyr Leu Leu Asn Leu Gly Tyr Glu Val His Gly
20 25 30Leu Lys Arg Arg Ser Ser Ser Ile Asn Thr Ser Arg Ile Asp His Leu
35 40 45Tyr Glu Asp Leu His Ser Asp His Lys Arg Arg Phe Phe Leu His Tyr
50 55 60Gly Asp Met Thr Asp Ser Ser Asn Leu Ile His Leu Ile Ala Thr Thr6570 75 80Lys Pro Thr Glu Ile Tyr Asn Leu Ala Ala Gln Ser His Val Lys Val
85 90 95Ser Phe Glu Thr Pro Glu Tyr Thr Ala Asn Ala Asp Gly Ile Gly Thr
100 105 110Leu Arg Ile Leu Glu Ala Met Arg Ile Leu Gly Leu Glu Lys Lys Thr
115 120 125Arg Phe Tyr Gln Ala Ser Thr Ser Glu Leu Tyr Gly Glu Val Leu Glu
130 135 140Thr Pro Gln Asn Glu Asn Thr Pro Phe Asn Pro Arg Ser Pro Tyr Ala145 150 155 160Val Ala Lys Met Tyr Ala Phe Tyr Ile Thr Lys Asn Tyr Arg Glu Ala
165 170 175Tyr Asn Leu Phe Ala Val Asn Gly Ile Leu Phe Asn His Glu Ser Arg
180 185 190Val Arg Gly Glu Thr Phe Val Thr Arg Lys Ile Thr Arg Ala Ala Ser
195 200 205Ala Ile Ala Tyr Asn Leu Thr Asp Cys Leu Tyr Leu Gly Asn Leu Asp
210 215 220Ala Lys Arg Asp Trp Gly His Ala Lys Asp Tyr Val Lys Met Met His225 230 235 240Leu Met Leu Gln Ala Pro Ile Pro Gln Asp Tyr Val Ile Ala Thr Gly
245 250 255Lys Thr Thr Ser Val Arg Asp Phe Val Lys Met Ser Phe Glu Phe He
260 265 270Gly Ile Asn Leu Glu Phe Gln Asn Thr Gly Ile Lys Glu Ile Gly Leu
275 280 285Ile Lys Ser Val Asp Glu Lys Arg Ala Asn Ala Leu Lys Leu Asn Leu
290 295 300Ser His Leu Lys Lys Gly Gln Ile Val Val Arg Ile Asp Glu Arg Tyr305 310 315 320Phe Arg Pro Thr Glu Val Asp Leu Leu Leu Gly Asp Pro Thr Lys Ala
325 330 335Glu Lys Glu Leu Asp Trp Val Arg Glu Tyr Asp Leu Lys Glu Leu Val
340 345 350Lys Asp Met Leu Glu Tyr Asp Leu Lys Glu Cys Gln Lys Asn Leu Tyr
355 360 365Leu Gln Asp Gly Gly Tyr Ile Leu Arg Asn Phe Tyr Glu
370 375 380
(2) Data for sequence 1173:
(i) sequence characteristics:
(A) length: 1116 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...1065
(D) Other information:
(xi) Description of the sequence: sequence 1173: CAGCAGTATC CCTATCGGTC AAGCCTTAAT GGCGTATTTC AACCCTACAA TCATCAAAAA 60AGGATAAAA ATG GAT AGC GTA ACT CTA GCA TGC GGG AAC GGA GGG AAA GAA 111
Met Asp Ser Va1 Thr Leu Ala Cys Gly Asn Gly Gly Lys Glu
1 5 10ACA AAC GCT TTG ATT GAG CGA GTC TTT ATG CCC TAT TTA AAA GAA TGG 159Thr Asn Ala Leu Ile GluArg Val Phe Met Pro Tyr Leu Lys Glu Trp15 20 25 30ATT GTT GCA TTT GAT GAA GAC GCC CCT AAA TTT GAA GCT AGT GGG GAA 207Ile Val Ala Phe Asp Glu Asp Ala Pro Lys Phe Glu Ala Ser Gly Glu
35 40 45TAT TGC GTG AGC ACG GAT AGT TTT GTC ATC ACG CCC TTA ATT TTT AAT 255Tyr Cys Val Ser Thr Asp Ser Phe Val Ile Thr Pro Leu Ile Phe Asn
50 55 60GGG GGC GAT ATA GGC AAG CTT TGC GTT TGC GGG AGT GCG AAT GAT GTG 303Gly Gly Asp Ile Gly Lys Leu Cys Val Cys Gly Ser Ala Asn Asp Val
65 70 75AGC GTG CAA GGG GGC GAA CCT TTG TAT TTG AAT ATG GGT TTT ATT TTA 351Ser Val Gln Gly Gly Glu Pro Leu Tyr Leu Asn Met Gly Phe Ile Leu
80 85 90GAA GAA GGC TTA GAA ATT TCT CTT TTA AAA CAA ATT TTA CAA TCC ATA 399Glu Glu Gly Leu Glu Ile Ser Leu Leu Lys Gln Ile Leu Gln Ser Ile95 100 105 110CAA AAA GAA TTG TTT AAA GCC AAC CTG AAA CTC CTC TCC CTA GAC ACT 447Gln Lys Glu Leu Phe Lys Ala Asn Leu Lys Leu Leu Ser Leu Asp Thr
115 120 125AAA GTC GTG CCA AAG GGG AGC GTG GAT AAG CTT TTT ATC AAC ACA ACC 495Lys Val Val Pro Lys Gly Ser Val Asp Lys Leu Phe Ile Asn Thr Thr
130 135 140TGC ATT GGT AAA ATC ATC AAG CCA GGG ATT TCT TCG TAC CAT TTA CAA 543Cys Ile Gly Lys Ile Ile Lys Pro Gly Ile Ser Ser Tyr His Leu Gln
145 150 155CAA GGG CAA GCC ATT ATC CTA AGC GAC ACT ATC GCC AAT CAT GGG GCA 591Gln Gly Gln Ala Ile Ile Leu Ser Asp Thr Ile Ala Asn His Gly Ala
160 165 170AGC TTA TTT GCG ATG CGT AAT GAA ATC AAG CTT AAA ACG AAT CTA GAA 639Ser Leu Phe Ala Met Arg Asn Glu Ile Lys Leu Lys Thr Asn Leu Glu175 180 185 190AGC GAT TGC CAA CTG CTC TAT CCC TTA TTA AAA CCC CTA TTT TTA AGC 687Ser Asp Cys Gln Leu Leu Tyr Pro Leu Leu Lys Pro Leu Phe Leu Ser
195 200 205GAT CTC AAA ATT GAT GCT TTA AGA GAT GCG ACT AGG GGC GGG TTA GCG 735Asp Leu Lys Ile Asp Ala Leu Arg Asp Ala Thr Arg Gly Gly Leu Ala
210 215 220AGC GTG CTG AAC GAA TGG GCG AAC AGC TCT AGA GTG AAA ATC GTT ATA 783Ser Val Leu Asn Glu Trp Ala Asn Ser Ser Arg Val Lys Ile Val Ile
225 230 235GAA GAA GAA AAA ATC CCC TTA AAA GAA GAA ACG AAA GGG ATT TGT GAG 831Glu Glu Glu Lys Ile Pro Leu Lys Glu Glu Thr Lys Gly Ile Cys Glu
240 245 250ATT TTA GGG TTA GAA CCC TAC GCG CTA GCC AAT GAG GGG GTG TTT GTT 879Ile Leu Gly Leu Glu Pro Tyr Ala Leu Ala Asn Glu Gly Val Phe Val255 260 265 270TTA GCG CTC AAT CAA AAA GAC GCC CCT AAA GCC TTA GAA ATT TTA AAA 927Leu Ala Leu Asn Gln Lys Asp Ala Pro Lys Ala Leu Glu Ile Leu Lys
275 280 285AGT AAC GAA AAA GCT AAA AAC GCT TGC GTG ATT GGC AAA GTG TTT GAA 975Ser Asn Glu Lys Ala Lys Asn Ala Cys Val Ile Gly Lys Val Phe Glu
290 295 300AAC CCT TAT CCT AGC GTG GTT TTA AAG AAC GCA TGG GGT TTT GAA AGG 1023Asn Pro Tyr Pro Ser Val Val Leu Lys Asn Ala Trp Gly Phe Glu Arg
305 310 315ATT TTA GAG GTG CCA GAG GGC GAA TTA TTG CCT AGG ATT TGT TAACACGCC 1074Ile Leu Glu Val Pro Glu Gly Glu Leu Leu Pro Arg Ile Cys
320 325 330GTCATTTTTT AATCGTTTTA AGCCTGCCCT AAAAATGGTT TA 1116
(2) Data for sequence 1174:
(i) sequence characteristics:
(A) length: 332 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1174: met Asp Ser Val Thr Leu Ala Cys Gly Asn Gly Gly Lys Glu Thr Asn 151015 Ala Leu Ile Glu Arg Val Phe Met Pro Tyr Leu Lys Glu Trp Ile Val
20 25 30Ala Phe Asp Glu Asp Ala Pro Lys Phe Glu Ala Ser Gly Glu Tyr Cys
35 40 45Val Ser Thr Asp Ser Phe Val Ile Thr Pro Leu Ile Phe Asn Gly Gly
50 55 60Asp Ile Gly Lys Leu Cys Val Cys Gly Ser Ala Asn Asp Val Ser Val65 70 75 80Gln Gly Gly Glu Pro Leu Tyr Leu Asn Met Gly Phe Ile Leu Glu Glu
85 90 95Gly Leu Glu Ile Ser Leu Leu Lys Gln Ile Leu Gln Ser Ile Gln Lys
100 105 110Glu Leu Phe Lys Ala Asn Leu Lys Leu Leu Ser Leu Asp Thr Lys Val
115 120 125Val Pro Lys Gly Ser Val Asp Lys Leu Phe Ile Asn Thr Thr Cys Ile
130 135 140Gly Lys Ile Ile Lys Pro Gly Ile Ser Ser Tyr His Leu Gln Gln Gly145 150 155 160Gln Ala Ile Ile Leu Ser Asp Thr Ile Ala Asn His Gly Ala Ser Leu
165 170 175Phe Ala Met Arg Asn Glu Ile Lys Leu Lys Thr Asn Leu Glu Ser Asp
180 185 190Cys Gln Leu Leu Tyr Pro Leu Leu Lys Pro Leu Phe Leu Ser Asp Leu
195 200 205Lys Ile Asp Ala Leu Arg Asp Ala Thr Arg Gly Gly Leu Ala Ser Val
210 215 220Leu Ash Glu Trp Ala Asn Ser Ser Arg Val Lys Ile Val Ile Glu Glu225 230 235 240Glu Lys Ile Pro Leu Lys Glu Glu Thr Lys Gly Ile Cys Glu Ile Leu
245 250 255Gly Leu Glu Pro Tyr Ala Leu Ala Asn Glu Gly Val Phe Val Leu Ala
260 265 270Leu Asn Gln Lys Asp Ala Pro Lys Ala Leu Glu Ile Leu Lys Ser Asn
275 280 285Glu Lys Ala Lys Asn Ala Cys Val Ile Gly Lys Val Phe Glu Asn Pro
290 295 300Tyr Pro Ser Val Val Leu Lys Asn Ala Trp Gly Phe Glu Arg Ile Leu305 310 315 320Glu Val Pro Glu Gly Glu Leu Leu Pro Arg Ile Cys
325 330
(2) Data for sequence 1175:
(i) sequence characteristics:
(A) length: 1033 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...1005
(D) Other information:
(xi) Description of the sequence: sequence 1175: AAAAGGATAT TTTGA ATG AAA AGA ATG TTA GCG GAG TTT GAA AAA ATC CAA 51
Met Lys Arg Met Leu Ala Glu Phe Glu Lys Ile Gln
1 5 10GCG ATT CTA ATG GCT TTC CCC CAT GAG TTT AGC GAC TGG GCG TAT TGT 99Ala Ile Leu Met Ala Phe Pro His Glu Phe Ser Asp Trp Ala Tyr Cys
15 20 25ATC AAA GAG GCT AGG GAA AGT TTT TTA AAC ATC ATT CAA ACC ATA GCC 147Ile Lys Glu Ala Arg Glu Ser Phe Leu Asn Ile Ile Gln Thr Ile Ala
30 35 40AAA CAC GCT AAA GTG CTA GTG TGC GTC CAC ACT AAC GAT ATT ATC GGT 195Lys His Ala Lys Val Leu Val Cys Val His Thr Asn Asp Ile Ile Gly45 50 55 60TAT GAA ACG CTT AAA AAC TTA CCC GGT GTA GAG ATC GCA AGG ATT GAC 243Tyr Glu Thr Leu Lys Asn Leu Pro Gly Val Glu Ile Ala Arg Ile Asp
65 70 75ACT AAC GAC ACA TGG GCT AGG GAT TTT GGA GCG ATC AGC GTT GAA AAT 291Thr Asn Asp Thr Trp Ala Arg Asp Phe Gly Ala Ile Ser Val Glu Asn
80 85 90CAT GGC GTT TTA GAG TGC TTG GAT TTT GGC TTT AAT GGC TGG GGG TTA 339His Gly Val Leu Glu Cys Leu Asp Phe Gly Phe Asn Gly Trp Gly Leu
95 100 105AAA TAC CCG TCC AAT TTA GAC AAT CAA GTG AAT TTC AAA CTC AAA AGT 387Lys Tyr Pro Ser Asn Leu Asp Asn Gln Val Asn Phe Lys Leu Lys Ser
110 115 120TTA GGG TTT TTA AAA CAC CCT TTA AAA ACG ATG CCC TAT ATT TTA GAG 435Leu Gly Phe Leu Lys His Pro Leu Lys Thr Met Pro Tyr Ile Leu Glu125 130 135 140GGC GGG AGT ATA GAA AGC GAT GGG GCT GGG AGC GTT TTA ACC AAC ACC 483Gly Gly Ser Ile Glu Ser Asp Gly Ala Gly Ser Val Leu Thr Asn Thr
145 150 155CAA TGC CTG TTA GAA AAA AAT CGT AAC CCC CAT TTG AAT CAA AAT GGA 531Gln Cys Leu Leu Glu Lys Asn Arg Asn Pro His Leu Asn Gln Asn Gly
160 165 170ATA GAA AAC ATG CTT AAA AAG GAA TTA GGG GCT AAA CAA GTG CTG TGG 579Ile Glu Asn Met Leu Lys Lys Glu Leu Gly Ala Lys Gln Val Leu Trp
175 180 185TAT TCT TAT GGC TAT CTC AAA GGC GAT GAT ACC GAT AGC CAT ACC GAC 627Tyr Ser Tyr Gly Tyr Leu Lys Gly Asp Asp Thr Asp Ser His Thr Asp
190 195 200ACG CTC GCT CGT TTT TTA GAT AAA GAC ACC ATT GTT TAT AGC ACA TGC 675Thr Leu Ala Arg Phe Leu Asp Lys Asp Thr Ile Val Tyr Ser Thr Cys205 210 215 220GAA GAT GAA AAC GAT GAG CAC TAC ACA GCC TTA AAA AAA ATG CAA GAA 723Glu Asp Glu Asn Asp Glu His Tyr Thr Ala Leu Lys Lys Met Gln Glu
225 230 235GAA TTA AAA ACC TTT AAA AAA CTA GAC GGC ACG CCC TAT AAA CTC ATC 771Glu Leu Lys Thr Phe Lys Lys Leu Asp Gly Thr Pro Tyr Lys Leu Ile
240 245 250CCC CTA GAA ATC CCT AAA GCC ATT TTT GAT GAA AAC CAA CAA CGC TTG 819Pro LeuGlu Ile Pro Lys Ala Ile Phe Asp Glu Asn Gln Gln Arg Leu
255 260 265CCG GCA ACT TAT GTG AAT TTT TTA TTG TGC AAT AAC GCT TTA ATC GTG 867Pro Ala Thr Tyr Val Asn Phe Leu Leu Cys Asn Asn Ala Leu Ile Val
270 275 280CCC ACT TAG AAC GAC CCT AAA GAC GCG CTC ATT TTA GAA ACC TTG AAA 915Pro Thr Tyr Asn Asp Pro Lys Asp Ala Leu Ile Leu Glu Thr Leu Lys285 290 295 300CAA CAC ACG CCC TTA GAA GTG ATA GGG GTT GAT TGC AAC ACC TTA ATC 963Gln His Thr Pro Leu Glu Val Ile Gly Val Asp Cys Asn Thr Leu Ile
305 310 315AAA CAG CAT GGA AGT TTG CAT TGT GTA ACG ATG CAA CTT TAT TGAACAAAA 1014Lys Gln His Gly Ser Leu His Cys Val Thr Met Gln Leu Tyr
320 325 330TCACGCTTTT TGGCGTGGT 1033
(2) Data of sequence 1176:
(i) sequence characteristics:
(A) length: 330 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1176: met Lys Arg Met Leu Ala Glu Phe Glu Lys Ile Gln Ala Ile Leu Met 151015 Ala Phe Pro His Glu Phe Ser Asp Trp Ala Tyr Cys Ile Lys Glu Ala
20 25 30Arg Glu Ser Phe Leu Asn Ile Ile Gln Thr Ile Ala Lys His Ala Lys
35 40 45Val Leu Val Cys Val His Thr AsnAsp Ile Ile Gly Tyr Glu Thr Leu
50 55 60Lys Asn Leu Pro Gly Val Glu Ile Ala Arg Ile Asp Thr Asn Asp Thr65 70 75 80Trp Ala Arg Asp Phe Gly Ala Ile Ser Val Glu Asn His Gly Val Leu
85 90 95Glu Cys Leu Asp Phe Gly Phe Asn Gly Trp Gly Leu Lys Tyr Pro Ser
100 105 110Asn Leu Asp Asn Gln Val Asn Phe Lys Leu Lys Ser Leu Gly Phe Leu
115 120 125Lys His Pro Leu Lys Thr Met Pro Tyr Ile Leu Glu Gly Gly Ser Ile
130 135 140Glu Ser Asp Gly Ala Gly Ser Val Leu Thr Asn Thr Gln Cys Leu Leu145 150 155 160Glu Lys Asn Arg Asn Pro His Leu Asn Gln Asn Gly Ile Glu Asn Met
165 170 175Leu Lys Lys Glu Leu Gly Ala Lys Gln Val Leu Trp Tyr Ser Tyr Gly
180 185 190Tyr Leu Lys Gly Asp Asp Thr Asp Ser His Thr Asp Thr Leu Ala Arg
195 200 205Phe Leu Asp Lys Asp Thr Ile Val Tyr Ser Thr Cys Glu Asp Glu Asn
210 215 220Asp Glu His Tyr Thr Ala Leu Lys Lys Met Gln Glu Glu Leu Lys Thr225 230 235 240Phe Lys Lys Leu Asp Gly Thr Pro Tyr Lys Leu Ile Pro Leu Glu Ile
245 250 255Pro Lys Ala Ile Phe Asp Glu Asn Gln Gln Arg Leu Pro Ala Thr Tyr
260 265 270Val Asn Phe Leu Leu Cys ASn Asn Ala Leu Ile Val ProThr Tyr Asn
275 280 285Asp Pro Lys Asp Ala Leu Ile Leu Glu Thr Leu Lys Gln His Thr Pro
290 295 300Leu Glu Val Ile Gly Val Asp Cys Asn Thr Leu Ile Lys Gln His Gly305 310 315 320Ser Leu His Cys Val Thr Met Gln Leu Tyr
325 330
(2) Data for sequence 1177:
(i) sequence characteristics:
(A) length: 449 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 73...408
(D) Other information:
(xi) Description of the sequence: sequence 1177: GCTTTATTCA AAAGAGCGAG GAGTTTAGAC GAGATAGCAA AATCATCAAT CTTTATCGCC 60TTTCAACGCC TA ATG TTT GCA GTG CAT GCT GCG ATG ATT ACG ACA TTA AAG 111
Met Phe Ala Val His Ala Ala Met Ile Thr Thr Leu Lys
1 5 10AAA GAA GTT TTC TTT CTT TAC CTT TAT ATC AAA TCA CTC AAA ATC CCG 159Lys Glu Val Phe Phe Leu Tyr Leu Tyr Ile Lys Ser Leu Lys Ile Pro
15 20 25ATT CCT ACT ACA CTG AAA TAC ATG ATT TCT TTA GGC AAA ATC AGA GAA 207Ile Pro Thr Thr Leu Lys Tyr Met Ile Ser Leu Gly Lys Ile Arg Glu30 35 40 45TTA GAT GTT TTA GCA AAT CTT GCT AAA CTT TGC CCT ACT TGT CAT AGG 255Leu Asp Val Leu Ala Asn Leu Ala Lys Leu Cys Pro Thr Cys His Arg
50 55 60GCT TTA AAA AAA GGA TCT AGC GAA GAG GAG TTT CAA AAA CGC TTG ATT 303Ala Leu Lys Lys Gly Ser Ser Glu Glu Glu Phe Gln Lys Arg Leu Ile
65 70 75AGA AAC ATT CTC AAT CGC AAT AAA GAC AAT TTA GAG TTT GCG CAA TTG 351Arg Asn Ile Leu Asn Arg Asn Lys Asp Asn Leu Glu Phe Ala Gln Leu
80 85 90CGT TTT GAA ACC GAT GAT TTT TCA ACG CTT ATT GAT CGT ATT TGT GAA 399Arg Phe Glu Thr Asp Asp Phe Ser Thr Leu Ile Asp Arg Ile Cys Glu
95 100 105AGC TTG AAA TGAATTATAA AATTTTAGAT TTATTTTGTG GGGCTGGGGG T 449Ser Leu Lys110
(2) Data of sequence 1178:
(i) sequence characteristics:
(A) length: 112 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1178: met Phe Ala Val His Ala Ala Met Ile Thr Thr Leu Lys Lys Glu Val 151015 Phe Phe Leu Tyr Leu Tyr Ile Lys Ser Leu Lys Ile Pro Ile Pro Thr
20 25 30Thr Leu Lys Tyr Met Ile Ser Leu Gly Lys Ile Arg Glu Leu Asp Val
35 40 45Leu Ala Asn Leu Ala Lys Leu Cys Pro Thr Cys His Arg Ala Leu Lys
50 5560Lys Gly Ser Ser Glu Glu Glu Phe Gln Lys Arg Leu Ile Arg Asn Ile65 70 75 80Leu Asn Arg Asn Lys Asp Asn Leu Glu Phe Ala Gln Leu Arg Phe Glu
85 90 95Thr Asp Asp Phe Ser Thr Leu Ile Asp Arg Ile Cys Glu Ser Leu Lys
100 105 110
(2) Data for sequence 1179:
(i) sequence characteristics:
(A) length: 420 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...375
(D) Other information:
(xi) Description of the sequence: sequence 1179: AAAAACTGGA ATCAAGGGGT TAAA ATG TTT TCT CAT GAA GTT TAT TTG GAG 51
Met Phe Ser His Glu Val Tyr Leu Glu
1 5GGT TGC ACC CTT GAA TTA AGA AAG ATT TGC GAT GAT TTT GAA AAA AAT 99Gly Cys Thr Leu Glu Leu Arg Lys Ile Cys Asp Asp Phe Glu Lys Asn10 15 20 25GCC ATG CAA GAT GAT TTA GGG CAG AAA CTC AGG AGT GAT GTG CTA GAG 147Ala Met Gln Asp Asp Leu Gly Gln Lys Leu Arg Ser Asp Val Leu Glu
30 35 40GAC ATG CTA AAA ATC GCG CAT GAT TTA GAA AAT TTA GAA GAT GAC ACC 195Asp Met Leu Lys Ile Ala His Asp LeuGlu Asn Leu Glu Asp Asp Thr
45 50 55CAA TAC CAA AGA AGA ATA ATT GAC GAG CAA ATT GAA GAA GCC AAA TCT 243Gln Tyr Gln Arg Arg Ile Ile Asp Glu Gln Ile Glu Glu Ala Lys Ser
60 65 70TTG ATG AGG CAA ATT GAT ATG AAT TTC CAT CCA TCA AGC GAG ATC GAT 291Leu Met Arg Gln Ile Asp Met Asn Phe His Pro Ser Ser Glu Ile Asp
75 80 85AGG CTT ATG CGT GAA GCC AAA GAG CAT GAA AGA GAA GCT AGT AAA AGA 339Arg Leu Met Arg Glu Ala Lys Glu His Glu Arg Glu Ala Ser Lys Arg90 95 100 105TAT GAT GAG TAT CTT AAA TCT AAG GAT AAA AAT GAT TGATGTGAAT GGTTTA 391Tyr Asp Glu Tyr Leu Lys Ser Lys Asp Lys Asn Asp
110 115TTAAAAGAAC TGGATGATGC CTTAGATAA 420
(2) Sequence 1180 data:
(i) sequence characteristics:
(A) length: 117 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1180: met Phe Ser His Glu Val Tyr Leu Glu Gly Cys Thr Leu Glu Leu Arg 151015 Lys Ile Cys Asp Asp Phe Glu Lys Asn Ala Met Gln Asp Asp Leu Gly
20 25 30Gln Lys Leu Arg Ser Asp Val Leu Glu Asp Met Leu Lys Ile Ala His
35 40 45Asp Leu Glu Asn Leu Glu Asp Asp Thr Gln Tyr Gln Arg Arg Ile Ile
50 55 60Asp Glu Gln Ile Glu Glu Ala Lys Ser Leu Met Arg Gln Ile Asp Met65 70 75 80Asn Phe His Pro Ser Ser Glu Ile Asp Arg Leu Met Arg Glu Ala Lys
85 90 95Glu His Glu Arg Glu Ala Ser Lys Arg Tyr Asp Glu Tyr Leu Lys Ser
100 105 110Lys Asp Lys Asn Asp
115
(2) Sequence 1181 data:
(i) sequence characteristics:
(A) length: 651 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 43...627
(D) Other information:
(xi) Description of the sequence: sequence 1181: GGTGCGTTTG TTGTAAAAAT TTTTGTTTGG AAGGAAAAGG CA ATG CTA GGA CTT 54
Met Leu Gly LeuGTA TTG TTA TAT GTT GGG ATT GTT TTA ATC AGC AAT GGG ATT TGC GGG 102Val Leu Leu Tyr Val Gly Ile Val Leu Ile Ser Asn Gly Ile Cys Gly 5 10 15 20TTA ACC AAA GTC GAT CCT AAA AGC ACT GCG GTG ATG AAC TTT TTT GTG 150Leu Thr Lys Val Asp Pro Lys Ser Thr Ala Val Met Asn Phe Phe Val
25 30 35GGC GGA CTT TCC ATT ATT TGT AAT ATA GTT GTC ATC ACT TAT TCT GCA 198Gly Gly Leu Ser IleIle Cys Asn Ile Val Val Ile Thr Tyr Ser Ala
40 45 50CTC CAC CCT ACA GCC CCT GTA GAA GGT GCT GAA GAT ATT GCT CAA GTA 246Leu His Pro Thr Ala Pro Val Glu Gly Ala Glu Asp Ile Ala Gln Val
55 60 65TCG CAC CAT TTG ACT AGT TTC TAT GGA CCA GCG ACT GGG TTA TTG TTT 294Ser His His Leu Thr Ser Phe Tyr Gly Pro Ala Thr Gly Leu Leu Phe
70 75 80GGT TTC ACC TAC TTG TAT GCG GCT ATC AAC CAC ACT TTT GGT TTG GAT 342Gly Phe Thr Tyr Leu Tyr Ala Ala Ile Asn His Thr Phe Gly Leu Asp85 90 95 100TGG AGG CCC TAC TCT TGG TAT AGC TTA TTC GTA GCG ATC AAC ACG ATT 390Trp Arg Pro Tyr Ser Trp Tyr Ser Leu Phe Val Ala Ile Asn Thr Ile
105 110 115CCT GCT GCG ATT TTA TCC CAC TAT AGC GAT ATG CTT GAT GAC CAC AAA 438Pro Ala Ala Ile Leu Ser His Tyr Ser Asp Met Leu Asp Asp His Lys
120 125 130GTG TTA GGC ATC ACT GAA GGC GAT TGG TGG GCG ATC ATT TGG TTG GCT 486Val Leu Gly Ile Thr Glu Gly Asp Trp Trp Ala Ile Ile Trp Leu Ala
135 140 145TGG GGT GTT TTG TGG CTT ACC GCT TTC ATT GAA AAC ATC TTG AAA ATC 534Trp Gly Val Leu Trp Leu Thr Ala Phe Ile Glu Asn Ile Leu Lys Ile
150 155 160CCT TTA GGG AAA TTC ACT CCA TGG CTT GCT ATC ATT GAG GGT ATT TTA 582Pro Leu Gly Lys Phe Thr Pro Trp Leu Ala Ile Ile Glu Gly Ile Leu165 170 175 180ACC GCT TGG ATC CCT GCT TGG TTG CTC TTT ATC CAA CAC TGG GTG TGAGA 632Thr Ala Trp Ile Pro Ala Trp Leu Leu Phe Ile Gln His Trp Val
185 190 195TGATCATAGA GCGTTTAGT 65l
(2) Sequence 1182 data:
(i) sequence characteristics:
(A) length: 195 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1182: met Leu Gly Leu Val Leu Leu Tyr Val Gly Ile Val Leu Ile Ser Asn 151015 Gly Ile Cys Gly Leu Thr Lys Val Asp Pro Lys Ser Thr Ala Val Met
20 25 30Asn Phe Phe Val Gly Gly Leu Ser Ile Ile Cys Asn Ile Val Val Ile
35 40 45Thr Tyr Ser Ala Leu His Pro Thr Ala Pro Val Glu Gly Ala Glu Asp
50 55 60Ile Ala Gln Val Ser His His Leu Thr Ser Phe Tyr Gly Pro Ala Thr65 70 75 80Gly Leu Leu Phe Gly Phe Thr Tyr Leu Tyr Ala Ala Ile Asn His Thr
85 90 95Phe Gly Leu Asp Trp Arg Pro Tyr Ser Trp Tyr Ser Leu Phe Val Ala
100 105 110Ile Asn Thr Ile Pro Ala Ala Ile Leu Ser His Tyr Ser Asp Met Leu
115 120 125Asp Asp His Lys Val Leu Gly Ile Thr Glu Gly Asp Trp Trp Ala Ile
130 135 140Ile Trp Leu Ala Trp Gly Val Leu Trp Leu Thr Ala Phe Ile Glu Asn145 150 155 160Ile Leu Lys Ile Pro Leu GlyLys Phe Thr Pro Trp Leu Ala Ile Ile
165 170 175Glu Gly Ile Leu Thr Ala Trp Ile Pro Ala Trp Leu Leu Phe Ile Gln
180 185 190His Trp Val
195
(2) Sequence 1183 data:
(i) sequence characteristics:
(A) length: 526 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 48...482
(D) Other information:
(xi) Description of the sequence: sequence 1183: GAAGGGCATT TGTGCTAAAA ACCACTAAAA AAAGCCTGTT GGTTTTT ATG GGG GTT 56
Met Gly Val
1TTT TTC CTT ATT TTT GGC GTG GAT CAA GCG ATT AAA TAC GCT ATT TTA 104Phe Phe Leu Ile Phe Gly Val Asp Gln Ala Ile Lys Tyr Ala Ile Leu
5 10 15GAA GGG TTT CGC TAT GAA AGT TTG ATG ATA GAT ATT GTT TTA GTG TTC 152Glu Gly Phe Arg Tyr Glu Ser Leu Met Ile Asp Ile Val Leu Val Phe20 25 30 35AAT AAA GGC GTG GCG TTT TCC TTG CTC AGT TTT TTA GAG GGG GGT TTG 200Asn Lys Gly Val Ala Phe Ser Leu Leu Ser Phe Leu Glu Gly Gly Leu
40 45 50AAA TAC TTG CAA ATC CTT TTG ATT TTA GGG CTT TTT ATC TTT TTA ATG 248Lys Tyr Leu Gln Ile Leu Leu Ile Leu Gly Leu Phe Ile Phe Leu Met
55 60 65CGC CAA AGG GAG CTT TTT AAA AAC CAT GCG ATA GAG TTT GGC ATG GTG 296Arg Gln Arg Glu Leu Phe Lys Asn His Ala Ile Glu Phe Gly Met Val
70 75 80TTT GGC GCC GGG GTT TCT AAT GTT TTA GAC CGG TTT GTG CAT GGG GGC 344Phe Gly Ala Gly Val Ser Asn Val Leu Asp Arg Phe Val His Gly Gly
85 90 95GTG GTG GAT TAT GTG TAT TAT CAT TAT GGC TTT GAT TTT GCC ATT TTT 392Val Val Asp Tyr Val Tyr Tyr His Tyr Gly Phe Asp Phe Ala Ile Phe100 105 110 115AAT TTC GCT GAT GTC ATG ATA GAT GTG GGC GTG GGC GTT TTA TTG TTG 440Asn Phe Ala Asp Val Met Ile Asp Val Gly Val Gly Val Leu Leu Leu
120 125 130AAA CAA TTC TTT TTT AAG CAA AAA CAA AAC AAA ATT AAG GCA TAATCACTC 491Lys Gln Phe Phe Phe Lys Gln Lys Gln Asn Lys Ile Lys Ala
135 140 145TTTTTAAAAT GAAAGGTCGC GTAGCTCAGT TGGTA 526
(2) Sequence 1184 data:
(i) sequence characteristics:
(A) length: 145 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1184: met Gly Val Phe Phe Leu Ile Phe Gly Val Asp Gln Ala Ile Lys Tyr 151015 Ala Ile Leu Glu Gly Phe Arg Tyr Glu Ser LeuMet Ile Asp Ile Val
20 25 30Leu Val Phe Asn Lys Gly Val Ala Phe Ser Leu Leu Ser Phe Leu Glu
35 40 45Gly Gly Leu Lys Tyr Leu Gln Ile Leu Leu Ile Leu Gly Leu Phe Ile
50 55 60Phe Leu Met Arg Gln Arg Glu Leu Phe Lys Asn His Ala Ile Glu Phe65 70 75 80Gly Met Val Phe Gly Ala Gly Val Ser Ash Val Leu Asp Arg Phe Val
85 90 95His Gly Gly Val Val Asp Tyr Val Tyr Tyr His Tyr Gly Phe Asp Phe
100 105 110Ala Ile Phe Asn Phe Ala Asp Val Met Ile Asp Val Gly Val Gly Val
115 120 125Leu Leu Leu Lys Gln Phe Phe Phe Lys Gln Lys Gln Asn Lys Ile Lys
130 135 140Ala145
(2) Sequence 1185 data:
(i) sequence characteristics:
(A) length: 1392 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 22...1356
(D) Other information:
(xi) Description of the sequence: sequence 1185: TTTAAAAGGT ATTTTATAAC G ATG AAA ATT TTT GGG ACT GAT GGC GTG AGG 51
Met Lys Ile Phe Gly Thr Asp Gly Val Arg
1 5 10GGT AAA GCA GGG GTG AAA CTC ACC CCC ATG TTT GTG ATG CGT TTA GGC 99Gly Lys Ala Gly Val Lys Leu Thr Pro Met Phe Val Met Arg Leu Gly
15 20 25ATT GCT GCC GGA TTG TAT TTT AAA AAA CAT TCT CAA ACG AAT AAA ATT 147Ile Ala Ala Gly Leu Tyr Phe Lys Lys His Ser Gln Thr Asn Lys Ile
30 35 40CTA ATC GGT AAA GAC ACC AGA AAA AGC GGC TAT ATG GTA GAA AAC GCT 195Leu Ile Gly Lys Asp Thr Arg Lys Ser Gly Tyr Met Val Glu Asn Ala
45 50 55TTA GTG AGC GCT CTA ACT TCC ATA GGC TAT AAT GTG ATT CAA ATA GGG 243Leu Val Ser Ala Leu Thr Ser Ile Gly Tyr Asn Val Ile Gln Ile Gly
60 65 70CCT ATG CCC ACC CCT GCG ATT GCG TTT TTA ACT GAA GAC ATG CGC TGT 291Pro Met Pro Thr Pro Ala Ile Ala Phe Leu Thr Glu Asp Met Arg Cys75 80 85 90GAT GCG GGT ATT ATG ATA AGC GCG AGC CAC AAC CCT TTT GAA GAT AAT 339Asp Ala Gly Ile Met Ile Ser Ala Ser His Asn Pro Phe Glu Asp Asn
95 100 105GGC ATT AAG TTT TTC AAT TCT TAT GGC TAT AAG CTT AAA GAA GAA GAA 387Gly Ile Lys Phe Phe Asn Ser Tyr Gly Tyr Lys Leu Lys Glu Glu Glu
110 115 120GAA AAA GCG ATT GAA GAA ATC TTT CAT GAT GAA GAA TTA CTG CAT TCT 435Glu Lys Ala Ile Glu Glu Ile Phe His Asp Glu Glu Leu Leu His Ser
125 130 135AGC TAT AAA GTG GGT GAG AGC GTC GGT AGC GCT AAA AGG ATA GAC GAT 483Ser Tyr Lys Val Gly GluSer Val Gly Ser Ala Lys Arg Ile Asp Asp
140 145 150GTC ATA GGG CGC TAT ATT GCA CAT TTA AAA CAC TCT TTC CCC AAA CAT 531Val Ile Gly Arg Tyr Ile Ala His Leu Lys His Ser Phe Pro Lys His155 160 165 170TTG AAT TTA CAG AGT TTA AGG ATC GTG CTA GAT ACG GCT AAT GGC GCG 579Leu Asn Leu Gln Ser Leu Arg Ile Val Leu Asp Thr Ala Asn Gly Ala
175 180 185GCT TAT AAG GTG GCT CCG GTC GTT TTT AGC GAG CTT GGG GCT GAT GTG 627Ala Tyr Lys Val Ala Pro Val Val Phe Ser Glu Leu Gly Ala Asp Val
190 195 200TTA GTG ATT AAT GAT GAG CCT AAC GGG TGT AAC ATT AAT GAT CAA TGC 675Leu Val Ile Asn Asp Glu Pro Asn Gly Cys Asn Ile Asn Asp Gln Cys
205 210 215GGG GCT TTA CAC CCC AAC CAA TTA AGC CAG GAA GTG AAA AAA TAC CGC 723Gly Ala Leu His Pro Asn Gln Leu Ser Gln Glu Val Lys Lys Tyr Arg
220 225 230GCA GAT TTA GGC TTT GCT TTT GAT GGC GAT GCT GAC AGG CTA GTG GTG 771Ala Asp Leu Gly Phe Ala Phe Asp Gly Asp Ala Asp Arg Leu Val Val235 240 245 250GTG GAT AAT TTA GGG AAT ATC GTG CAT GGG GAT AAG CTT TTA GGG GTG 819Val Asp Asn Leu Gly Asn Ile Val His Gly Asp Lys Leu Leu Gly Val
255 260 265TTA GGG GTT TAT CAA AAA TCT AAA AAC GCC CTT TCT TCT CAA GCG GTT 867Leu Gly Val Tyr Gln Lys Ser Lys Asn Ala Leu Ser Ser Gln Ala Val
270 275 280GTC GCC ACA AAC ATG AGC AAT TTA GCC CTT AAA GAA TAT TTA AAA TCC 915Val Ala Thr Asn Met Ser Asn Leu Ala Leu Lys Glu Tyr Leu Lys Ser
285 290 295CAA GAT TTG GAA TTG AAG CAT TGC GCG ATT GGG GAT AAG TTT GTG AGC 963Gln Asp Leu Glu Leu Lys His Cys Ala Ile Gly Asp Lys Phe Val Ser
300 305 310GAA TGC ATG CAA TTG AAT AAA GCC AAT TTT GGA GGC GAG CAA AGC GGG 1011Glu Cys Met Gln Leu Asn Lys Ala Asn Phe Gly Gly Glu Gln Ser Gly315 320 325 330CAT ATC ATT TTT AGC GAT TAC GCT AAA ACA GGC GAT GGT TTG GTG TGC 1059His Ile Ile Phe Ser Asp Tyr Ala Lys Thr Gly Asp Gly Leu Val Cys
335 340 345GCT TTG CAA GTG AGC GCG TTA GTG TTA GAA AGC AAG CAG GTA AGC TCT 1107Ala Leu Gln Val Ser Ala Leu Val Leu Glu Ser Lys Gln Val Ser Ser
350 355 360GTT GCG TTA AAC CCC TTT GAA TTA TAC CCC CAA AGC CTA GTG AAT TTG 1155Val Ala Leu Asn Pro Phe Glu Leu Tyr Pro Gln Ser Leu Val Asn Leu
365 370 375AAT GTC CAA AAA AAG CCC CCT TTA GAA AGC CTG AAA GGT TAT AGC GCT 1203Asn Val Gln Lys Lys Pro Pro Leu Glu Ser Leu Lys Gly Tyr Ser Ala
380 385 390CTT TTA AAA GAA TTA GAC AAG CTA GAA ATC CGC CAT TTG ATC CGT TAT 1251Leu Leu Lys Glu Leu Asp Lys Leu Glu Ile Arg His Leu Ile Arg Tyr395 400 405 410AGC GGC ACT GAA AAC AAA TTG CGA ATC CTT TTA GAA GCT AAA GAT GAA 1299Ser Gly Thr Glu Asn Lys Leu Arg Ile Leu Leu Glu Ala Lys Asp Glu
415 420 425AAG CTT TTA GAA TCC AAA ATG CAA GAA TTA AAA GAG TTT TTT GAA GGG 1347Lys Leu Leu Glu Ser Lys Met Gln Glu Leu Lys Glu Phe Phe Glu Gly
430 435 440CAT TTG TGC TAAAAACCAC TAAAAAAAGC CTGTTGGTTT TTATGG 1392His Leu Cys
445
(2) Sequence 1186 data:
(i) sequence characteristics:
(A) length: 445 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1186: met Lys Ile Phe Gly Thr Asp Gly Val Arg Gly Lys Ala Gly Val Lys 151015 Leu Thr Pro Met Phe Val Met Arg Leu Gly Ile Ala Ala Gly Leu Tyr
20 25 30Phe Lys Lys His Ser Gln Thr Asn Lys Ile Leu Ile Gly Lys Asp Thr
35 40 45Arg Lys Ser Gly Tyr Met Val Glu Asn Ala Leu Val Ser Ala Leu Thr
50 55 60Ser Ile Gly Tyr Asn Val Ile Gln Ile Gly Pro Met Pro Thr Pro Ala65 70 75 80Ile Ala Phe Leu Thr Glu Asp Met Arg Cys Asp Ala Gly Ile Met Ile
85 90 95Ser Ala Ser His Asn Pro Phe Glu Asp Asn Gly Ile Lys Phe Phe Asn
100 105 110Ser Tyr Gly Tyr Lys Leu Lys Glu Glu Glu Glu Lys Ala Ile Glu Glu
115 120 125Ile Phe His Asp Glu Glu Leu Leu His Ser Ser Tyr Lys Val Gly Glu
130 135 140Ser Val Gly Ser Ala Lys Arg Ile Asp Asp Val Ile Gly Arg Tyr Ile145 150 155 160Ala His Leu Lys His Ser Phe Pro LysHis Leu Asn Leu Gln Ser Leu
165 170 175Arg Ile Val Leu Asp Thr Ala Asn Gly Ala Ala Tyr Lys Val Ala Pro
180 185 190Val Val Phe Ser Glu Leu Gly Ala Asp Val Leu Val Ile Asn Asp Glu
195 200 205Pro Asn Gly Cys Asn Ile Asn Asp Gln Cys Gly Ala Leu His Pro Asn
210 215 220Gln Leu Ser Gln Glu Val Lys Lys Tyr Arg Ala Asp Leu Gly Phe Ala225 230 235 240Phe Asp Gly Asp Ala Asp Arg Leu Val Val Val Asp Asn Leu Gly Asn
245 250 255Ile Val His Gly Asp Lys Leu Leu Gly Val Leu Gly Val Tyr Gln Lys
260 265 270Ser Lys Asn Ala Leu Ser Ser Gln Ala Val Val Ala Thr Asn Met Ser
275 280 285Asn Leu Ala Leu Lys Glu Tyr Leu Lys Ser Gln Asp Leu Glu Leu Lys
290 295 300His Cys Ala Ile Gly Asp Lys Phe Val Ser Glu Cys Met Gln Leu Asn305 310 315 320Lys Ala Asn Phe Gly Gly Glu Gln Ser Gly His Ile Ile Phe Ser Asp
325 330 335Tyr Ala Lys Thr Gly Asp Gly Leu Val Cys Ala Leu Gln Val Ser Ala
340 345 350Leu Val Leu Glu Ser Lys Gln Val Ser Ser Val Ala Leu Asn Pro Phe
355 360 365Glu Leu Tyr Pro Gln Ser Leu Val Asn Leu Asn Val Gln Lys Lys Pro
370 375380Pro Leu Glu Ser Leu Lys Gly Tyr Ser Ala Leu Leu Lys Glu Leu Asp385 390 395 400Lys Leu Glu Ile Arg His Leu Ile Arg Tyr Ser Gly Thr Glu Asn Lys
405 410 415Leu Arg Ile Leu Leu Glu Ala Lys Asp Glu Lys Leu Leu Glu Ser Lys
420 425 430Met Gln Glu Leu Lys Glu Phe Phe Glu Gly His Leu Cys
435 440 445
(2) Sequence 1187 data:
(i) sequence characteristics:
(A) length: 483 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...441
(D) Other information:
(xi) Description of the sequence: sequence 1187: TTTTATCAAA GGATTCTT ATG ACA AAG ACC GCT AAA GTC AAT GAC ATC GTT 51
Met Thr Lys Thr Ala Lys Val Asn Asp Ile Val
1 5 10CGT GAT TGG GTC GTT TTA GAC GCC AAA GAC AAG GTT TTT GGC CGC TTG 99Arg Asp Trp Val Val Leu Asp Ala Lys Asp Lys Val Phe Gly Arg Leu
15 20 25ATC ACT GAA ATC GCT GTG CTT TTA AGA GGG AAA CAC CGC CCT TTT TAC 147Ile Thr Glu Ile Ala Val Leu Leu Arg Gly Lys His Arg Pro Phe Tyr
30 35 40ACC CCT AAT GTG GAT TGT GGG GAT TTT GTG GTG GTT ATC AAC GCT AAT 195Thr Pro Asn Val Asp Cys Gly Asp Phe Val Val Val Ile Asn Ala Asn
45 50 55AAG GTT AAA TTT TCA GGC ATG AAA TTA GAG GAT AAA GAG TAT TTT ACC 243Lys Val Lys Phe Ser Gly Met Lys Leu Glu Asp Lys Glu Tyr Phe Thr60 65 70 75CAT TCA GGC TAT TTT GGC AGC ACT AAG AGC AAG ACT CTC CAA GAA ATG 291His Ser Gly Tyr Phe Gly Ser Thr Lys Ser Lys Thr Leu Gln Glu Met
80 85 90CTA GAA AAA GCC CCT GAA AAG CTC TAC CAC TTA GCC GTT AGG GGC ATG 339Leu Glu Lys Ala Pro Glu Lys Leu Tyr His Leu Ala Val Arg Gly Met
95 100 105CTC CCT AAA ACG AAA TTA GGG AAA GCG ATG ATT AAA AAA CTC AAA GTT 387Leu Pro Lys Thr Lys Leu Gly Lys Ala Met Ile Lys Lys Leu Lys Val
110 115 120TAT CGT GAT GAT AAG CAC CCT CAC ACC GCA CAA ACT AGC AAA AAG GAC 435Tyr Arg Asp Asp Lys His Pro His Thr Ala Gln Thr Ser Lys Lys Asp
125 130 135GCT AAA TGAGAAAAAT CTATGCTACC GGTAAAAGAA AAACCGCTAT CG 483Ala Lys140
(2) Sequence 1188 data:
(i) sequence characteristics:
(A) length: 141 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1188: met Thr Lys Thr Ala Lys Val Asn AspIle Val Arg Asp Trp Val Val 151015 Leu Asp Ala Lys Asp Lys Val Phe Gly Arg Leu Ile Thr Glu Ile Ala
20 25 30Val Leu Leu Arg Gly Lys His Arg Pro Phe Tyr Thr Pro Asn Val Asp
35 40 45Cys Gly Asp Phe Val Val Val Ile Asn Ala Asn Lys Val Lys Phe Ser
50 55 60Gly Met Lys Leu Glu Asp Lys Glu Tyr Phe Thr His Ser Gly Tyr Phe65 70 75 80Gly Ser Thr Lys Ser Lys Thr Leu Gln Glu Met Leu Glu Lys Ala Pro
85 90 95Glu Lys Leu Tyr His Leu Ala Val Arg Gly Met Leu Pro Lys Thr Lys
100 105 110Leu Gly Lys Ala Met Ile Lys Lys Leu Lys Val Tyr Arg Asp Asp Lys
115 120 125His Pro His Thr Ala Gln Thr Ser Lys Lys Asp Ala Lys
130 135 140
(2) Sequence 1189 data:
(i) sequence characteristics:
(A) length: 2107 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...2058
(D) Other information:
(xi) Description of the sequence: sequence 1189: TAGCTTTTGA TTGAAAGC ATG GGT TCT TAC TTT ATG GAG TGT CCA ATG AAA 51
Met Gly Ser Tyr Phe Met Glu Cys Pro Met Lys
1 5 10AAG AAA GCT AAC GAA GAA AAA GCC CAA AAA AGA GCT AAA ACA GAA GCC 99Lys Lys Ala Asn Glu Glu Lys Ala Gln Lys Arg Ala Lys Thr Glu Ala
15 20 25AAA GCA GAA GCC ACA CAA GAA AAT AAA ACT AAA GAA AAC AAT AAA GCC 147Lys Ala Glu Ala Thr Gln Glu Asn Lys Thr Lys Glu Asn Asn Lys Ala
30 35 40AAA GAA AGC AAA ATT AAA GAA AGC AAA ATC AAA GAA GCT AAA GCG AAA 195Lys Glu Ser Lys Ile Lys Glu Ser Lys Ile Lys Glu Ala Lys Ala Lys
45 50 55GAA CCT ATT CCT GTT AAA AAG CTT AGT TTT AAT GAA GCG TTA GAA GAA 243Glu Pro Ile Pro Val Lys Lys Leu Ser Phe Asn Glu Ala Leu Glu Glu60 65 70 75TTG TTC GCT AAT TCC TTA AGC GAT TGC GTT TCT TAT GAG TCC ATC ATT 291Leu Phe Ala Asn Ser Leu Ser Asp Cys Val Ser Tyr Glu Ser Ile Ile
80 85 90CAA ATC AGC GCG AAA GTC CCC ACT CTA GCC CAA ATC AAA AAA ATC AAA 339Gln Ile Ser Ala Lys Val Pro Thr Leu Ala Gln Ile Lys Lys Ile Lys
95 100 105GAA TTG TGC CAA AAA TAC CAA AAG AAA TTA GTC AGC TCT TCA GAA TAC 387Glu Leu Cys Gln Lys Tyr Gln Lys Lys Leu Val Ser Ser Ser Glu Tyr
110 115 120GCT AAA AAA CTC AAT GCG ATT GAC AAG ATT AAA AAA ACC GAA GAA AAG 435Ala Lys Lys Leu Asn Ala Ile Asp Lys Ile Lys Lys Thr Glu Glu Lys
125 130 135CAA AAA GTT TTA GAT GAA GAA TTA GAA GAT GGC TAT GAC TTT TTG AAA 483Gln Lys Val Leu Asp Glu Glu Leu Glu Asp Gly Tyr Asp Phe Leu Lys140 145 150 155GAA AAG GAT TTT TTA GAG TGG AGC AGA AGC GAT AGC CCA GTG CGC ATG 531Glu Lys Asp Phe Leu Glu Trp Ser Arg Ser Asp Ser Pro Val Arg Met
160 165 170TAT TTG CGC GAA ATG GGG GAT ATA AAA CTT TTA AGC AAA GAT GAA GAG 579Tyr Leu Arg Glu Met Gly Asp Ile Lys Leu Leu Ser Lys Asp Glu Glu
175 180 185ATT GAA TTG AGC AAG CAA ATC CGC TTG GGT GAA GAC ATT ATT TTA GAC 627Ile Glu Leu Ser Lys Gln Ile Arg Leu Gly Glu Asp Ile Ile Leu Asp
190 195 200GCG ATC TGC TCG GTG CCG TAT TTG ATT GAT TTT ATC TAT GCG TAT AAA 675Ala Ile Cys Ser Val Pro Tyr Leu Ile Asp Phe Ile Tyr Ala Tyr Lys
205 210 215GAC GCT TTA ATC AAT CGT GAA AGA AGG GTT AAA GAG CTT TTC AGG AGC 723Asp Ala Leu Ile Asn Arg Glu Arg Arg Val Lys Glu Leu Phe Arg Ser220 225 230 235TTT GAT GAT GAC GAT GAA AAT AGC GTG AGC GAT TCT AAA AAA GAT GAA 771Phe Asp Asp Asp Asp Glu Asn Ser Val Ser Asp Ser Lys Lys Asp Glu
240 245 250GAC AAC GAA GAA GAT GAA GAA AAC GAA GAA AGG AAA AAA GTC GTT TCT 819Asp Asn Glu Glu Asp Glu Glu Asn Glu Glu Arg Lys Lys Val Val Ser
255 260 265GAA AAA GAC AAG AAG CGT GTA GAA AAG GTT CAA GAA AGC TTT AAA GCC 867Glu Lys Asp Lys Lys Arg Val Glu Lys Val Gln Glu Ser Phe Lys Ala
270 275 280CTA GAC AAG GCT AAA AAA GAA TGG CTT AAA GCC CTT GAA GCC CCC ATA 915Leu Asp Lys Ala Lys Lys Glu Trp Leu Lys Ala Leu Glu Ala Pro Ile
285 290 295GAT GAA AGA GAA GAC GAA TTG GTG CGT TCA TTG ACC CTA GCT TAC AAA 963Asp Glu Arg Glu Asp Glu Leu Val Arg Ser Leu Thr Leu Ala Tyr Lys300 305 310 315CGC CAA ACA CTC AAA GAC AGA CTC TAT GAT TTA GAA CCT ACC AGC AAA 1011Arg Gln Thr Leu Lys Asp Arg Leu Tyr Asp Leu Glu Pro Thr Ser Lys
320 325 330CTG ATT AAT GAA TTA GTC AAA ACG ATG GAA ACC ACT TTA AAA AGC GGC 1059Leu Ile Asn Glu Leu Val Lys Thr Met Glu Thr Thr Leu Lys Ser Gly
335 340 345GAT GGG TTT GAA AAA GAG TTG AAA CGC TTG GAA TAC AAA CTG CCC TTA 1107Asp Gly Phe Glu Lys Glu Leu Lys Arg Leu Glu Tyr Lys Leu Pro Leu
350 355 360TTC AAT GAC ACT CTC ATC GCA AAC CAT AAA AAA ATC CTT GCC AAT ATC 1155Phe Asn Asp Thr Leu Ile Ala Asn His Lys Lys Ile Leu Ala Asn Ile
365 370 375ACT AAC ATG ACT AAA GAA GAT ATT ATC GCT CAA GTG CCA GAA GCG ACT 1203Thr Asn Met Thr Lys Glu Asp Ile Ile Ala Gln Val Pro Glu Ala Thr380 385 390 395ATG GTG AGC GTG TAT ATG GAT CTT AAA AAG CTT TTT TTG ACT AAA GAA 1251Met Val Ser Val Tyr Met Asp Leu Lys Lys Leu Phe Leu Thr Lys Glu
400 405 410GCG AGC GAA GAA GGC TTT GAT CTA GCC CCC AAC AAG CTA AAA GAA ATT 1299Ala Ser Glu Glu Gly Phe Asp Leu Ala Pro Asn Lys Leu Lys Glu Ile
415 420 425TTA GAG CAA ATC AAA AGA GGG AAG TTG ATT TCC GAT CGC GCT AAA AAC 1347Leu Glu Gln Ile Lys Arg Gly Lys Leu Ile Ser Asp Arg Ala Lys Asn
430 435 440AAA ATG GCT AAA TCC AAT TTA AGG TTG GTG GTG AGC ATC GCT AAA CGA 1395Lys Met Ala Lys Ser Asn Leu Arg Leu Val Val Ser Ile Ala Lys Arg
445 450 455TTC ACG AGC AGA GGC TTA CCA TTC TTG GAT TTG ATT CAA GAG GGC AAT 1443Phe Thr Ser Arg Gly Leu Pro Phe Leu Asp Leu Ile Gln Glu Gly Asn460 465 470 475ATT GGC TTG ATG AAA GCG GTG GAT AAG TTT GAG CAT GAA AAG GGC TTC 1491Ile Gly Leu Met Lys Ala Val Asp Lys Phe Glu His Glu Lys Gly Phe
480 485 490AAG TTT TCT ACC TAT GCG ACC TGG TGG ATC AAA CAA GCT ATC AGC AGA 1539Lys Phe Ser Thr Tyr Ala Thr Trp Trp Ile Lys Gln Ala Ile Ser Arg
495 500 505GCC ATA GCC GAT CAG GCC CGC ACT ATC CGC ATC CCC ATT CAC ATG ATT 1587Ala Ile Ala Asp Gln Ala Arg Thr Ile Arg Ile Pro Ile His Met Ile
510 515 520GAT ACG ATT AAT CGC ATC AAT AAA GTC ATG CGC AAA CAC ATT CAA GAA 1635Asp Thr Ile Asn Arg Ile Asn Lys Val Met Arg Lys His Ile Gln Glu
525 530 535AAC GGC AAA GAG CCT GAT TTA GAA GTG GTG GCT GAA GAA GTG GGG CTT 1683Asn Gly Lys Glu Pro Asp Leu Glu Val Val Ala Glu Glu Val Gly Leu540 545 550 555TCG TTA GAT AAA GTG AAG AAT GTG ATT AAG GTG ACT AAA GAG CCT ATC 1731Ser Leu Asp Lys Val Lys Asn Val Ile Lys Val Thr Lys Glu Pro Ile
560 565 570AGT TTG GAA ACC CCA GTC GGC AAT GAT GAT GAT GGC AAG TTT GGG GAT 1779Ser Leu Glu Thr Pro Val Gly Asn Asp Asp Asp Gly Lys Phe Gly Asp
575 580 585TTC GTG GAA GAT AAG AAT ATC GTC AGC TCC ATT GAT CAC ATC ATG CGA 1827Phe Val GluAsp Lys Asn Ile Val Ser Ser Ile Asp His Ile Met Arg
590 595 600GAA GAT TTG AAA GCA CAA ATT GAA AGC GTT TTG GAT CAG TTG AAT GAG 1875Glu Asp Leu Lys Ala Gln Ile Glu Ser Val Leu Asp Gln Leu Asn Glu
605 610 615CGA GAA AAA GCG GTG ATC CGC ATG CGT TTT GGG CTT TTA GAC GAT GAA 1923Arg Glu Lys Ala Val Ile Arg Met Arg Phe Gly Leu Leu Asp Asp Glu620 625 630 635AGC GAT CGA ACT TTA GAA GAA ATT GGC AAG GAA TTG AAT GTT ACT AGA 1971Ser Asp Arg Thr Leu Glu Glu Ile Gly Lys Glu Leu Asn Val Thr Arg
640 645 650GAA AGG GTG CGC CAG ATT GAA AGC TCT GCG ATT AAA AAA TTG AGA AGC 2019Glu Arg Val Arg Gln Ile Glu Ser Ser Ala Ile Lys Lys Leu Arg Ser
655 660 665CCG CAG TAC GGG CGC ATT TTA AGA AAC TAT TTG CGC ATT TGATGTTAAG GT 2070Pro Gln Tyr Gly Arg Ile Leu Arg Asn Tyr Leu Arg Ile
670 675 680TTCTCTAAAG CATGCGTTAT TTTCTTGTAG TTTTCTT 2107
(2) Sequence 1190 data:
(i) sequence characteristics:
(A) length: 680 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1190: met Gly Ser Tyr Phe Met Glu Cys Pro Met Lys Lys Lys Ala Asn Glu 151015 Glu Lys Ala Gln Lys Arg Ala Lys Thr Glu Ala Lys Ala Glu Ala Thr
2025 30Gln Glu Asn Lys Thr Lys Glu Asn Asn Lys Ala Lys Glu Ser Lys Ile
35 40 45Lys Glu Ser Lys Ile Lys Glu Ala Lys Ala Lys Glu Pro Ile Pro Val
50 55 60Lys Lys Leu Ser Phe Asn Glu Ala Leu Glu Glu Leu Phe Ala Asn Ser65 70 75 80Leu Ser Asp Cys Val Ser Tyr Glu Ser Ile Ile Gln Ile Ser Ala Lys
85 90 95Val Pro Thr Leu Ala Gln Ile Lys Lys Ile Lys Glu Leu Cys Gln Lys
100 105 110Tyr Gln Lys Lys Leu Val Ser Ser Ser Glu Tyr Ala Lys Lys Leu Asn
115 120 125Ala Ile Asp Lys Ile Lys Lys Thr Glu Glu Lys Gln Lys Val Leu Asp
130 135 140Glu Glu Leu Glu Asp Gly Tyr Asp Phe Leu Lys Glu Lys Asp Phe Leu145 150 155 160Glu Trp Ser Arg Ser Asp Ser Pro Val Arg Met Tyr Leu Arg Glu Met
165 170 175Gly Asp Ile Lys Leu Leu Ser Lys Asp Glu Glu Ile Glu Leu Ser Lys
180 185 190Gln Ile Arg Leu Gly Glu Asp Ile Ile Leu Asp Ala Ile Cys Ser Val
195 200 205Pro Tyr Leu Ile Asp Phe Ile Tyr Ala Tyr Lys Asp Ala Leu Ile Asn
210 215 220Arg Glu Arg Arg Val Lys Glu Leu Phe Arg Ser Phe Asp Asp Asp Asp225 230 235 240Glu Asn Ser Val Ser Asp Ser Lys Lys Asp Glu Asp Asn Glu Glu Asp
245250 255Glu Glu Asn Glu Glu Arg Lys Lys Val Val Ser Glu Lys Asp Lys Lys
260 265 270Arg Val Glu Lys Val Gln Glu Ser Phe Lys Ala Leu Asp Lys Ala Lys
275 280 285Lys Glu Trp Leu Lys Ala Leu Glu Ala Pro Ile Asp Glu Arg Glu Asp
290 295 300Glu Leu Val Arg Ser Leu Thr Leu Ala Tyr Lys Arg Gln Thr Leu Lys305 310 315 320Asp Arg Leu Tyr Asp Leu Glu Pro Thr Ser Lys Leu Ile Asn Glu Leu
325 330 335Val Lys Thr Met Glu Thr Thr Leu Lys Ser Gly Asp Gly Phe Glu Lys
340 345 350Glu Leu Lys Arg Leu Glu Tyr Lys Leu Pro Leu Phe Asn Asp Thr Leu
355 360 365Ile Ala Asn His Lys Lys Ile Leu Ala Asn Ile Thr Asn Met Thr Lys
370 375 380Glu Asp Ile Ile Ala Gln Val Pro Glu Ala Thr Met Val Ser Val Tyr385 390 395 400Met Asp Leu Lys Lys Leu Phe Leu Thr Lys Glu Ala Ser Glu Glu Gly
405 410 415Phe Asp Leu Ala Pro Asn Lys Leu Lys Glu Ile Leu Glu Gln Ile Lys
420 425 430Arg Gly Lys Leu Ile Ser Asp Arg Ala Lys Asn Lys Met Ala Lys Ser
435 440 445Asn Leu Arg Leu Val Val Ser Ile Ala Lys Arg Phe Thr Ser Arg Gly
450 455 460Leu Pro Phe Leu Asp Leu Ile Gln Glu Gly Asn Ile Gly Leu Met Lys465 470 475 480Ala Val Asp Lys Phe Glu His Glu Lys Gly Phe Lys Phe Ser Thr Tyr
485 490 495Ala Thr Trp Trp Ile Lys Gln Ala Ile Ser Arg Ala Ile Ala Asp Gln
500 505 510Ala Arg Thr Ile Arg Ile Pro Ile His Met Ile Asp Thr Ile Asn Arg
515 520 525Ile Asn Lys Val Met Arg Lys His Ile Gln Glu Asn Gly Lys Glu Pro
530 535 540Asp Leu Glu Val Val Ala Glu Glu Val Gly Leu Ser Leu Asp Lys Val545 550 555 560Lys Asn Val Ile Lys Val Thr Lys Glu Pro Ile Ser Leu Glu Thr Pro
565 570 575Val Gly Asn Asp Asp Asp Gly Lys Phe Gly Asp Phe Val Glu Asp Lys
580 585 590Asn Ile Val Ser Ser Ile Asp His Ile Met Arg Glu Asp Leu Lys Ala
595 600 605Gln Ile Glu Ser Val Leu Asp Gln Leu Asn Glu Arg Glu Lys Ala Val
610 615 620Ile Arg Met Arg Phe Gly Leu Leu Asp Asp Glu Ser Asp Arg Thr Leu625 630 635 640Glu Glu Ile Gly Lys Glu Leu Asn Val Thr Arg Glu Arg Val Arg Gln
645 650 655Ile Glu Ser Ser Ala Ile Lys Lys Leu Arg Ser Pro Gln Tyr Gly Arg
660 665 670Ile Leu Arg Asn Tyr Leu Arg Ile
675 680
(2) Sequence 1191 data:
(i) sequence characteristics:
(A) length: 745bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...717
(D) Other information:
(xi) Description of the sequence: sequence 1191: AAGAATACGT GTGATTGGGA GAAA ATG GTG CAA AAA ATT GGC ATT TTA GGG 51
Met Val Gln Lys Ile Gly Ile Leu Gly
1 5GCG ATG AGA GAA GAA ATA ACC CCT ATA CTA GAA TTG TTT GGC GTG GAT 99Ala Met Arg Glu Glu Ile Thr Pro Ile Leu Glu Leu Phe Gly Val Asp10 15 20 25TTT GAA GAG ATC CCT TTA GGG GGG AAT GTC TTC CAT AAA GGC GTT TAT 147Phe Glu Glu Ile Pro Leu Gly Gly Asn Val Phe His Lys Gly Val Tyr
30 35 40CAC AAC AAG GAA ATC ATT GTC GCT TAT AGC AAG ATT GGC AAG GTG CAT 195His Asn Lys Glu Ile Ile Val Ala Tyr Ser Lys Ile Gly Lys Val His
45 50 55TCC ACT TTA ACC ACA ACG AGC ATG ATT TTA GCG TTT GGC GTT CAA AAG 243Ser Thr Leu Thr Thr Thr Ser Met Ile Leu Ala Phe Gly Val Gln Lys
60 65 70GTG CTT TTT AGC GGG GTG GCT GGA AGC TTA GTT AAA GAT TTA AAA ATC 291Val Leu Phe Ser Gly Val Ala Gly Ser Leu Val Lys Asp Leu Lys Ile
75 80 85AAT GAT TTA CTA GTG GCT ATT CAA TTA GTC CAG CAT GAT GTG GAT TTG 339AsnAsp Leu Leu Val Ala Ile Gln Leu Val Gln His Asp Val Asp Leu90 95 100 105AGC GCG TTT GAT CAC CCT TTA GGG TTC ATC CCA GAA AGC GCG ATT TTT 387Ser Ala Phe Asp His Pro Leu Gly Phe Ile Pro Glu Ser Ala Ile Phe
110 115 120ATT GAA ACG AGC GAA AGT TTG AAC GCT TTG GCT AAA GAA GTC GCT AAT 435Ile Glu Thr Ser Glu Ser Leu Asn Ala Leu Ala Lys Glu Val Ala Asn
125 130 135GAA CAG CAT ATC GTG CTC AAA GAA GGC GTC ATC GCA TCA GGC GAT CAG 483Glu Gln His Ile Val Leu Lys Glu Gly Val Ile Ala Ser Gly Asp Gln
140 145 150TTT GTG CAT AGC AAA GAA AGG AAA GAG TTT TTA GTT AGC GAG TTT AAA 531Phe Val His Ser Lys Glu Arg Lys Glu Phe Leu Val Ser Glu Phe Lys
155 160 165GCG AGC GCG GTG GAA ATG GAG GGG GCG AGC GTG GCG TTT GTG TGC CAA 579Ala Ser Ala Val Glu Met Glu Gly Ala Ser Val Ala Phe Val Cys Gln170 175 180 185AAA TTT GGC GTG CCA TGC TGT GTG TTA AGG AGC ATT AGC GAT AAC GCT 627Lys Phe Gly Val Pro Cys Cys Val Leu Arg Ser Ile Ser Asp Asn Ala
190 195 200GAT GAG GAA GCT AAC ATG AGC TTT GAT GCG TTT TTA GAA AAA AGC GCT 675Asp Glu Glu Ala Asn Met Ser Phe Asp Ala Phe Leu Glu Lys Ser Ala
205 210 215CAA ACT TCA GCG AAA TTC TTA AAA AGC ATG GTG GAT GAG CTT TAGGGTTTG 726Gln Thr Ser Ala Lys Phe Leu Lys Ser Met Val Asp Glu Leu
220 225 230TTTTTATAGA GGGGTGGAA 745
(2) Sequence 1192 data:
(i) sequence characteristics:
(A) length: 231 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1192: met Val Gln Lys Ile Gly Ile Leu Gly Ala Met Arg Glu Glu Ile Thr 15l 015 Pro Ile Leu Glu Leu Phe Gly Val Asp Phe Glu Glu Ile Pro Leu Gly
20 25 30Gly Asn Val Phe His Lys Gly Val Tyr His Asn Lys Glu Ile Ile Val
35 40 45Ala Tyr Ser Lys Ile Gly Lys Val His Ser Thr Leu Thr Thr Thr Ser
50 55 60Met Ile Leu Ala Phe Gly Val Gln Lys Val Leu Phe Ser Gly Val Ala65 70 75 80Gly Ser Leu Val Lys Asp Leu Lys Ile Asn Asp Leu Leu Val Ala Ile
85 90 95Gln Leu Val Gln His Asp Val Asp Leu Ser Ala Phe Asp His Pro Leu
100 105 110Gly Phe Ile Pro Glu Ser Ala Ile Phe Ile Glu Thr Ser Glu Ser Leu
115 120 125Asn Ala Leu Ala Lys Glu Val Ala Asn Glu Gln His Ile Val Leu Lys
130 135 140Glu Gly Val Ile Ala Ser Gly Asp Gln Phe Val His Ser Lys Glu Arg145 150 155 160Lys Glu Phe Leu Val Ser Glu Phe Lys Ala Ser Ala Val Glu Met Glu
165 170 175Gly Ala Ser Val Ala Phe Val Cys Gln Lys Phe Gly Val Pro Cys Cys
180 185 190Val Leu Arg Ser Ile Ser Asp Asn Ala Asp Glu Glu Ala Asn Met Ser
195 200 205Phe Asp Ala Phe Leu Glu Lys Ser Ala Gln Thr Ser Ala Lys Phe Leu
210 215 220Lys Ser Met Val Asp Glu Leu225 230
(2) Sequence 1193 data:
(i) sequence characteristics:
(A) length: 1986 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 56...1945
(D) Other information:
(xi) Description of the sequence: sequence 1193: GGTGTCCTTA AACAGCAGGG TGAAAGAGAT TTTAAAAGAA AGCGCTCTGC ATTCT ATG 58
Met
1CAA GAT AGT TTG CAT TTT AAG GTT AAT GAA GTG CAA GGG GTT TTA GAA 106Gln Asp Ser Leu His Phe Lys Val Asn Glu Val Gln Gly Val Leu Glu
5 10 15AAC ACT TAT ACG AGC ATG GGC ATT GTT AAA GAA ATG CTC CCT AAA GAC 154Asn Thr Tyr Thr Ser Met Gly Ile Val Lys Glu Met Leu Pro Lys Asp
20 25 30ACC AAA AGA GAA ATC AAA ATC GGC TTG TTA AAA AAC TTC ATT TTA GCC 202Thr Lys Arg Glu Ile LysIle Gly Leu Leu Lys Asn Phe Ile Leu Ala
35 40 45AAT TCG CAT GTC GCT GGG GTG AGC ATG TTT TTT AAA GGC AGA GAA GAT 250Asn Ser His Val Ala Gly Val Ser Met Phe Phe Lys Gly Arg Glu Asp50 55 60 65TTA AGA TTA ACG CTT TTA AGG GAT AAC AAT ACG ATT AAG CTA GTG GAA 298Leu Arg Leu Thr Leu Leu Arg Asp Asn Asn Thr Ile Lys Leu Val Glu
70 75 80AAT CCG TCA TTA GAG AAT AGC CCT TTA GCG CAA AAA GCG ATG AAA AAT 346Asn Pro Ser Leu Glu Asn Ser Pro Leu Ala Gln Lys Ala Met Lys Asn
85 90 95AAA GAA ATT TCT AAA AGT TTG GGT TAT TAT AGG AAA ATG CCT AAT GGG 394Lys Glu Ile Ser Lys Ser Leu Gly Tyr Tyr Arg Lys Met Pro Asn Gly
100 105 110GCG GAA GTT TAT GGG GTG GAT ATT CTT TTA CCT TTA TTG AAT GAG AAC 442Ala Glu Val Tyr Gly Val Asp Ile Leu Leu Pro Leu Leu Asn Glu Asn
115 120 125GCT CAA GAG GTT GTA GGG GCT TTG ATG ATT TTT ATT TCC ATT GAC AGC 490Ala Gln Glu Val Val Gly Ala Leu Met Ile Phe Ile Ser Ile Asp Ser130 135 140 145TTC AGC AAT GAA ATC ACT AAA AAC AGG AGC GAT TTA TTT TTA ATT GGC 538Phe Ser Asn Glu Ile Thr Lys Asn Arg Ser Asp Leu Phe Leu Ile Gly
150 155 160ACT AAA GGT AAA GTG CTT TTG AGC GCG AAT AAG AGT TTG CAA GAC AAA 586Thr Lys Gly Lys Val Leu Leu Ser Ala Asn Lys Ser Leu Gln Asp Lys
165 170 175CCT ATC GCA GAA ATT TAT AAG AGC GTG CCT AAA GCC ACC AAC GAA GTG 634Pro Ile Ala Glu Ile Tyr Lys Ser Val Pro Lys Ala Thr Asn Glu Val
180 185 190ATG GCT ATT TTA GAA AAC GGC TCT AAA GCG ACT TTA GAA TAC TTA GAT 682Met Ala Ile Leu Glu Asn Gly Ser Lys Ala Thr Leu Glu Tyr Leu Asp
195 200 205CCC TTT AGC CAT AAG GAA AAT TTT TTA GCC GTT GAA ACC TTT AAA ATG 730Pro Phe Ser His Lys Glu Asn Phe Leu Ala Val Glu Thr Phe Lys Met210 215 220 225CTA GGC AAA ACA GAA AGT AAA GAC AAT CTT AAT TGG ATG ATC GCT TTA 778Leu Gly Lys Thr Glu Ser Lys Asp Asn Leu Asn Trp Met Ile Ala Leu
230 235 240ATC ATT GAA AAA GAC AAG GTC TAT GAG CAA GTA GGC TCG GTG CGT TTT 826Ile Ile Glu Lys Asp Lys Val Tyr Glu Gln Val Gly Ser Val Arg Phe
245 250 255GTG GTG ATC ATA GCG AGC GCA ATC ATG GTG TTA GCC TTG ATT ATA GCG 874Val Val Ile Ile Ala Ser Ala Ile Met Val Leu Ala Leu Ile Ile Ala
260 265 270ATC ACT CTC TTA ATG CGA GCG ATC GTG AGC AGT CGT TTG GAA GCC GTT 922Ile Thr Leu Leu Met Arg Ala Ile Val Ser Ser Arg Leu Glu Ala Val
275 280 285TCT AGC ACC TTG TCT CAT TTC TTT AAA TTA TTG AAC AAT CAA GCC AAT 970Ser Ser Thr Leu Ser His Phe Phe Lys Leu Leu Asn Asn Gln Ala Asn290 295 300 305TCT AGC GGT ATT AAA TTG ATT GAA GCG AAA TCC AAT GAC GAG TTA GGC 1018Ser Ser Gly Ile Lys Leu Ile Glu Ala Lys Ser Asn Asp Glu Leu Gly
310 315 320CGC ATG CAA ACA GCG ATC AAT AAA AAT ATC TTG CAA ACC CAA AAA ATC 1066Arg Met Gln Thr Ala Ile Asn Lys Asn Ile Leu Gln Thr Gln Lys Ile
325 330 335ATG CAA GAA GAC AGG CAA GCCGTC CAA GAC ACC ATT AAA GTG GTT TCA 1114Met Gln Glu Asp Arg Gln Ala Val Gln Asp Thr Ile Lys Val Val Ser
340 345 350GAT GTG AAA GCA GGG AAT TTT GCG GTG CGC ATC ACG GCT GAG CCC GCA 1162Asp Val Lys Ala Gly Asn Phe Ala Val Arg Ile Thr Ala Glu Pro Ala
355 360 365AGC CCT GAT TTG AAA GAA TTG AGG GAC GCG CTA AAT GGG ATC ATG GAT 1210Ser Pro Asp Leu Lys Glu Leu Arg Asp Ala Leu Asn Gly Ile Met Asp370 375 380 385TAT TTG CAA GAA AGC GTA GGG ACT CAC ATG CCA AGC ATT TTC AAA ATC 1258Tyr Leu Gln Glu Ser Val Gly Thr His Met Pro Ser Ile Phe Lys Ile
390 395 400TTT GAA AGC TAT TCT GGT TTG GAT TTT AGA GGC CGG ATC CAA AAC GCT 1306Phe Glu Ser Tyr Ser Gly Leu Asp Phe Arg Gly Arg Ile Gln Asn Ala
405 410 415TCG GGT AGG GTG GAA CTG GTT ACT AAC GCT TTA GGG CAA GAA ATC CAA 1354Ser Gly Arg Val Glu Leu Val Thr Asn Ala Leu Gly Gln Glu Ile Gln
420 425 430AAA ATG CTA GAA ACT TCG TCT AAT TTT GCC AAA GAT TTA GCG AAC GAT 1402Lys Met Leu Glu Thr Ser Ser Asn Phe Ala Lys Asp Leu Ala Asn Asp
435 440 445AGC GCG AAT TTA AAA GAG TGC GTG CAA AAT TTA GAA AAA GCT TCA AAC 1450Ser Ala Asn Leu Lys Glu Cys Val Gln Asn Leu Glu Lys Ala Ser Asn450 455 460 465TCC CAA CAC AAA AGC TTG ATG GAA ACT TCC AAA ACG ATA GAA AAT ATC 1498Ser Gln His Lys Ser Leu Met Glu Thr Ser Lys Thr Ile Glu Asn Ile
470 475 480ACC ACT TCC ATT CAA GGC GTG AGC TCT CAA AGT GAA GCC ATG ATT GAA 1546Thr Thr Ser Ile Gln Gly ValSer Ser Gln Ser Glu Ala Met Ile Glu
485 490 495CAA GGG CAA GAC ATT AAA AGC ATT GTA GAA ATC ATT AGA GAT ATT GCT 1594Gln Gly Gln Asp Ile Lys Ser Ile Val Glu Ile Ile Arg Asp Ile Ala
500 505 510GAT CAA ACC AAT CTT TTA GCC TTA AAC GCC GCT ATT GAA GCC GCA AGG 1642Asp Gln Thr Asn Leu Leu Ala Leu Asn Ala Ala Ile Glu Ala Ala Arg
515 520 525GCC GGC GAG CAT GGC AGA GGC TTT GCG GTG GTG GCT GAT GAG GTA AGA 1690Ala Gly Glu His Gly Arg Gly Phe Ala Val Val Ala Asp Glu Val Arg530 535 540 545AAG CTC GCT GAA AGG ACG CAA AAA TCG CTC AGC GAG ATT GAA GCC AAT 1738Lys Leu Ala Glu Arg Thr Gln Lys Ser Leu Ser Glu Ile Glu Ala Asn
550 555 560ATC AAT ATT TTA GTG CAA AGC ATT TCA GAC ACG AGC GAA AGC ATT AAA 1786Ile Asn Ile Leu Val Gln Ser Ile Ser Asp Thr Ser Glu Ser Ile Lys
565 570 575AAC CAG GTT AAA GAA GTG GAA GAA ATC AAC GCT TCT ATT GAA GCC TTA 1834Asn Gln Val Lys Glu Val Glu Glu Ile Asn Ala Ser Ile Glu Ala Leu
580 585 590AGA TCG GTT ACT GAG GGC AAT CTA AAA ATC GCT AGC GAT TCT TTA GAA 1882Arg Ser Val Thr Glu Gly Asn Leu Lys Ile Ala Ser Asp Ser Leu Glu
595 600 605ATC AGT CAA GAA ATT GAC AAA GTT TCT AAC GAT ATT TTA GAA GAT GTG 1930Ile Ser Gln Glu Ile Asp Lys Val Ser Asn Asp Ile Leu Glu Asp Val610 615 620 625AAT AAA AAG CAG TTT TAATGCTCAT TCATATTTGC TGCTCAGTGG ATAACCTCTA T 1986Asn Lys Lys Gln Phe
630
1986
(2) Sequence 1194 data:
(i) sequence characteristics:
(A) length: 630 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1194: met Gln Asp Ser Leu His Phe Lys Val Asn Glu Val Gln Gly Val Leu 151015 Glu Asn Thr Tyr Thr Ser Met Gly Ile Val Lys Glu Met Leu Pro Lys
20 25 30Asp Thr Lys Arg Glu Ile Lys Ile Gly Leu Leu Lys Asn Phe Ile Leu
35 40 45Ala Asn Ser His Val Ala Gly Val Ser Met Phe Phe Lys Gly Arg Glu
50 55 60Asp Leu Arg Leu Thr Leu Leu Arg Asp Asn Asn Thr Ile Lys Leu Val65 70 75 80Glu Asn Pro Ser Leu Glu Asn Ser Pro Leu Ala Gln Lys Ala Met Lys
85 90 95Asn Lys Glu Ile Ser Lys Ser Leu Gly Tyr Tyr Arg Lys Met Pro Asn
100 105 110Gly Ala Glu Val Tyr Gly Val Asp Ile Leu Leu Pro Leu Leu Asn Glu
115 120 125Asn Ala Gln Glu Val Val Gly Ala Leu Met Ile Phe Ile Ser Ile Asp
130 135 140Ser Phe Ser Asn Glu Ile Thr Lys Asn Arg Ser Asp Leu Phe Leu Ile145 150 155 160Gly Thr Lys Gly Lys Val Leu Leu Ser Ala Asn Lys Ser Leu Gln Asp
165 170 175Lys Pro Ile Ala Glu Ile Tyr Lys Ser Val Pro Lys Ala Thr Asn Glu
180 185 190Val Met Ala Ile Leu Glu Asn Gly Ser Lys Ala Thr Leu Glu Tyr Leu
195 200 205Asp Pro Phe Ser His Lys Glu Asn Phe Leu Ala Val Glu Thr Phe Lys
210 215 220Met Leu Gly Lys Thr Glu Ser Lys Asp Asn Leu Asn Trp Met Ile Ala225 230 235 240Leu Ile Ile Glu Lys Asp Lys Val Tyr Glu Gln Val Gly Ser Val Arg
245 250 255Phe Val Val Ile Ile Ala Ser Ala Ile Met Val Leu Ala Leu Ile Ile
260 265 270Ala Ile Thr Leu Leu Met Arg Ala Ile Val Ser Ser Arg Leu Glu Ala
275 280 285Val Ser Ser Thr Leu Ser His Phe Phe Lys Leu Leu Asn Asn Gln Ala
290 295 300Asn Ser Ser Gly Ile Lys Leu Ile Glu Ala Lys Ser Asn Asp Glu Leu305 310 315 320Gly Arg Met Gln Thr Ala Ile Asn Lys Asn Ile Leu Gln Thr Gln Lys
325 330 335Ile Met Gln Glu Asp Arg Gln Ala Val Gln Asp Thr Ile Lys Val Val
340 345 350Ser Asp Val Lys Ala Gly Asn Phe Ala Val Arg Ile Thr Ala Glu Pro
355 360 365Ala Ser Pro Asp Leu Lys Glu Leu Arg Asp Ala Leu Asn Gly Ile Met
370 375 380Asp Tyr Leu Gln Glu Ser Val Gly Thr His Met Pro Ser Ile Phe Lys385 390 395 400Ile Phe Glu Ser Tyr Ser Gly Leu Asp Phe Arg Gly Arg Ile Gln Asn
405 410 415Ala Ser Gly Arg Val Glu Leu Val Thr Asn Ala Leu Gly Gln Glu Ile
420 425 430Gln Lys Met Leu Glu Thr Ser Ser Asn Phe Ala Lys Asp Leu Ala Asn
435 440 445Asp Ser Ala Asn Leu Lys Glu Cys Val Gln Asn Leu Glu Lys Ala Ser
450 455 460Asn Ser Gln His Lys Ser Leu Met Glu Thr Ser Lys Thr Ile Glu Asn465 470 475 480Ile Thr Thr Ser Ile Gln Gly Val Ser Ser Gln Ser Glu Ala Met Ile
485 490 495Glu Gln Gly Gln Asp Ile Lys Ser Ile Val Glu Ile Ile Arg Asp Ile
500 505 510Ala Asp Gln Thr Asn Leu Leu Ala Leu Asn Ala Ala Ile Glu Ala Ala
515 520 525Arg Ala Gly Glu His Gly Arg Gly Phe Ala Val Val Ala Asp Glu Val
530 535 540Arg Lys Leu Ala Glu Arg Thr Gln Lys Ser Leu Ser Glu Ile Glu Ala545 550 555 560Asn Ile Asn Ile Leu Val Gln Ser Ile Ser Asp Thr Ser Glu Ser Ile
565 570 575Lys Asn Gln Val Lys Glu Val Glu Glu Ile Asn Ala Ser Ile Glu Ala
580 585 590Leu Arg Ser Val Thr Glu Gly Asn Leu Lys Ile Ala Ser Asp Ser Leu
595 600 605Glu Ile Ser Gln Glu Ile Asp Lys Val Ser Asn Asp Ile Leu Glu Asp
610 615 620Val Asn Lys Lys Gln Phe625 630
(2) Sequence 1195 data:
(i) sequence characteristics:
(A) length: 1758 bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 8...1702
(D) Other information:
(xi) Description of the sequence: sequence 1195: GAGATAA ATG ATG TTT TCT TCA ATG TTT GCT TCG TTG GGG ACT CGT ATC 49
Met Met Phe Ser Ser Met Phe Ala Ser Leu Gly Thr Arg Ile
1 5 10ATG CTG GTC GTG TTA GCC GCT CTT TTA GGT TTA GGG GGG CTT TTT ATT 97Met Leu Val Val Leu Ala Ala Leu Leu Gly Leu Gly Gly Leu Phe Ile15 20 25 30GGT TTT GTA AAG GTT ATG CAA AAA GAT GTG TTA GCG CAA CTC ATG GAG 145Gly Phe Val Lys Val Met Gln Lys Asp Val Leu Ala Gln Leu Met Glu
35 40 45CAT TTA GAA ACC GGG CAA TAC AAA AAG CGT GAA AAA ACG CTC GCT TAC 193His Leu Glu Thr Gly Gln Tyr Lys Lys Arg Glu Lys Thr Leu Ala Tyr
50 55 60ATG ACA AAA ATT ATT GAA CAG GGC ATT CAT GAG TAT TAC AAA AAT TTT 241Met Thr Lys Ile Ile Glu Gln Gly Ile His Glu Tyr Tyr Lys Asn Phe
65 70 75GAC AAT GCT ACT GCA AGA AAA ATG GCG TTA GAT TAT TTC AAA CGC ATC 289Asp Asn Ala Thr Ala Arg Lys Met Ala Leu Asp Tyr Phe Lys Arg Ile
80 85 90AAC GAC GAT AAG GGC ATG ATT TAT ATG GTG GTG GTG GAT AAA AAC GGG 337Asn Asp Asp Lys Gly Met Ile Tyr Met Val Val Val Asp Lys Asn Gly95 100 105 110GTG GTA TTG TTT GAT CCG GTC AAT CCT AAA ACC GTA GNC CAA TCA GGG 385Val Val Leu Phe Asp Pro Val Asn Pro Lys Thr Val Xaa Gln Ser Gly
115 120 125CTT GAC GCT CAG AGC GTT GAT GGG GTG TAT TAT GTT AGG GGG TAT TTG 433Leu Asp Ala Gln Ser Val Asp Gly Val Tyr Tyr Val Arg Gly Tyr Leu
130 135 140GAG GCG GCC AAA AAA GGG GGA GGC TAC ACT TAT TAT AAA ATG CCT AAA 481Glu Ala Ala Lys Lys Gly Gly Gly Tyr Thr Tyr Tyr Lys Met Pro Lys
145 150 155TAC GAT GGA GGC GTA CCG GAG AAA AAA TTC GCC TAC TCG CAT TAT GAT 529Tyr Asp Gly Gly Val Pro Glu Lys Lys Phe Ala Tyr Ser His Tyr Asp
160 165 170GAA GTT TCT CAA ATG GTG ATC GCA ACG ACT TCC TAT TAC ACT GAC ATT 577Glu Val Ser Gln Met Val Ile Ala Thr Thr Ser Tyr Tyr Thr Asp Ile175 180 185 190AAC ACA GAA AAT AAA GCG ATC AAA GAA GGC GTG AAT AAG GTT TTT GAT 625Asn Thr Glu Asn Lys Ala Ile Lys Glu Gly Val Asn Lys Val Phe Asp
195 200 205GAA AAC ACC ACG AAA TTA TTC CTT TGG ATA CTG ACA GCG ACG ATA GCG 673Glu Asn Thr Thr Lys Leu Phe Leu Trp Ile Leu Thr Ala Thr Ile Ala
210 215 220CTA GTG GTT TTG ACGCTC ATA TAC GCT AAA TTA AGG ATC GTG AAA CGC 721Leu Val Val Leu Thr Leu Tle Tyr Ala Lys Leu Arg Ile Val Lys Arg
225 230 235ATT GAT GAA CTG GTC CTT AAA ATC AAC GCT TTT AGC CGT GGG GAT AAG 769Ile Asp Glu Leu Val Leu Lys Ile Asn Ala Phe Ser Arg Gly Asp Lys
240 245 250GAT TTG AGA GCC AAA ATT GAT GTG GGT GAT CGC AAC GAT GAA ATC TCG 817Asp Leu Arg Ala Lys Ile Asp Val Gly Asp Arg Asn Asp Glu Ile Ser255 260 265 270CAA GTG GGC CGT GGG ATC AAT TTG TTT GTG GAA AAC GCC CGC TTG ATT 865Gln Val Gly Arg Gly Ile Asn Leu Phe Val Glu Asn Ala Arg Leu Ile
275 280 285ATG GAA GAG ATT AAA GGG ATT TCC ACC CTC AAT AAA ACT TCA ATG GAT 913Met Glu Glu Ile Lys Gly Ile Ser Thr Leu Asn Lys Thr Ser Met Asp
290 295 300AAA TTA GTC CAA ATC ACG CAA GAA ACC CAA AAG AGC ATG AAA GAT TCC 961Lys Leu Val Gln Ile Thr Gln Glu Thr Gln Lys Ser Met Lys Asp Ser
305 310 315TCA ACC ACC CTA AAT TCC GTG AAA AAT AAA GCC ACT GAT ATA GCG AGC 1009Ser Thr Thr Leu Asn Ser Val Lys Asn Lys Ala Thr Asp Ile Ala Ser
320 325 330ATG ATG AAT GCT TCC ATA GAG CAA TCT CAA GGG TTA AGG AAG CGT TTG 1057Met Met Asn Ala Ser Ile Glu Gln Ser Gln Gly Leu Arg Lys Arg Leu335 340 345 350ATT GAA ACG CAA GGG CTG GTC AAA GAG AGC AAG GAT GCG ATC GGG GAT 1105Ile Glu Thr Gln Gly Leu Val Lys Glu Ser Lys Asp Ala Ile Gly Asp
355 360 365TTA TTT TCT CAA ATC ACA GAG AGC GCG CAC ACT GAA GAG GAA CTC TCT 1153Leu Phe Ser Gln Ile Thr GluSer Ala His Thr Glu Glu Glu Leu Ser
370 375 380AGC AAA GTG GAG CAG CTA AGC CGT AAC GCT GAT GAT GTC AAA TCC ATT 1201Ser Lys Val Glu Gln Leu Ser Arg Asn Ala Asp Asp Val Lys Ser Ile
385 390 395CTG GAT ATT ATC AAT GAT ATT GCC GAT CAA ACG AAT TTA TTA GCC CTA 1249Leu Asp Ile Ile Asn Asp Ile Ala Asp Gln Thr Asn Leu Leu Ala Leu
400 405 410AAC GCT GCT ATT GAA GCC GCA AGG GCT GGC GAG CAT GGC AGA GGC TTT 1297Asn Ala Ala Ile Glu Ala Ala Arg Ala Gly Glu His Gly Arg Gly Phe415 420 425 430GCG GTG GTG GCT GAT GAA GTT AGG AAT TTA GCC GGG CGC ACT CAA AAG 1345Ala Val Val Ala Asp Glu Val Arg Asn Leu Ala Gly Arg Thr Gln Lys
435 440 445TCT TTA GCC GAA ATC AAT TCC ACT ATC ATG GTG ATT GTC CAA GAA ATC 1393Ser Leu Ala Glu Ile Asn Ser Thr Ile Met Val Ile Val Gln Glu Ile
450 455 460AAT GCC GTG AGT TCG CAA ATG AAT CTC AAT TCG CAA AAA ATG GAG CGT 1441Asn Ala Val Ser Ser Gln Met Asn Leu Asn Ser Gln Lys Met Glu Arg
465 470 475TTG AGC GAT ATG AGT AAA AGC GTG CAA GAA ACT TAC GAA AAA ATG AGT 1489Leu Ser Asp Met Ser Lys Ser Val Gln Glu Thr Tyr Glu Lys Met Ser
480 485 490TCT AAT TTA AGC TCA GTC GTG TCA GAC AGC AAT CAA AGC ATG GAC GAT 1537Ser Asn Leu Ser Ser Val Val Ser Asp Ser Asn Gln Ser Met Asp Asp495 500 505 510TAC GCC AAA TCC GGA CAC CAA ATT GAA GTT ATG GTA AGC GAT TTT GCA 1585Tyr Ala Lys Ser Gly His Gln Ile Glu Val Met Val Ser Asp Phe Ala
515 520525GAG GTG GAA AAA GTG GCT TCT AAG ACT TTA GCG GAT TCT TCA GAT ATT 1633
Glu Val Glu Lys Val Ala Ser Lys Thr Leu Ala Asp Ser Ser Asp Ile
530 535 540TTA AAC ATC GCT ACG CAT GTG AGT GGA ACG ACC ATG AAT TTA GAC AAA 1681Leu Asn Ile Ala Thr His Val Ser Gly Thr Thr Met Asn Leu Asp Lys
545 550 555CAA GTG AAT TTG TTT AAA ACT TAATCAGGGG GAGTTTATTA AAAAAGGGTT GGAT 1736Gln Val Asn Leu Phe Lys Thr
560 565TGTTAAAAGT TTCTGTGATC AC 1758
(2) Sequence 1196 data:
(i) sequence characteristics:
(A) length: 565 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1196: met Met Phe Ser Ser Met Phe Ala Ser Leu Gly Thr Arg Ile Met Leu 151015 Val Val Leu Ala Ala Leu Leu Gly Leu Gly Gly Leu Phe Ile Gly Phe
20 25 30Val Lys Val Met Gln Lys Asp Val Leu Ala Gln Leu Met Glu His Leu
35 40 45Glu Thr Gly Gln Tyr Lys Lys Arg Glu Lys Thr Leu Ala Tyr Met Thr
50 55 60Lys Ile Ile Glu Gln Gly Ile His Glu Tyr Tyr Lys Asn Phe Asp Asn65 70 75 80Ala Thr Ala Arg Lys Met Ala Leu Asp Tyr Phe Lys Arg Ile Asn Asp
85 90 95Asp Lys Gly Met Ile Tyr Met Val Val Val Asp Lys Asn Gly Val Val
100 105 110Leu Phe Asp Pro Val Asn Pro Lys Thr Val Xaa Gln Ser Gly Leu Asp
115 120 125Ala Gln Ser Val Asp Gly Val Tyr Tyr Val Arg Gly Tyr Leu Glu Ala
130 135 140Ala Lys Lys Gly Gly Gly Tyr Thr Tyr Tyr Lys Met Pro Lys Tyr Asp145 150 155 160Gly Gly Val Pro Glu Lys Lys Phe Ala Tyr Ser His Tyr Asp Glu Val
165 170 175Ser Gln Met Val Ile Ala Thr Thr Ser Tyr Tyr Thr Asp Ile Asn Thr
180 185 190Glu Asn Lys Ala Ile Lys Glu Gly Val Asn Lys Val Phe Asp Glu Asn
195 200 205Thr Thr Lys Leu Phe Leu Trp Ile Leu Thr Ala Thr Ile Ala Leu Val
210 215 220Val Leu Thr Leu Ile Tyr Ala Lys Leu Arg Ile Val Lys Arg Ile Asp225 230 235 240Glu Leu Val Leu Lys Ile Asn Ala Phe Ser Arg Gly Asp Lys Asp Leu
245 250 255Arg Ala Lys Ile Asp Val Gly Asp Arg Asn Asp Glu Ile Ser Gln Val
260 265 270Gly Arg Gly Ile Asn Leu Phe Val Glu Asn Ala Arg Leu Ile Met Glu
275 280 285Glu Ile Lys Gly Ile Ser Thr Leu Asn Lys Thr Ser Met Asp Lys Leu
290 295 300Val Gln Ile Thr Gln Glu Thr Gln Lys Ser Met Lys Asp Ser Ser Thr305310 315 320Thr Leu Asn Ser Val Lys Asn Lys Ala Thr Asp Ile Ala Ser Met Met
325 330 335Asn Ala Ser Ile Glu Gln Ser Gln Gly Leu Arg Lys Arg Leu Ile Glu
340 345 350Thr Gln Gly Leu Val Lys Glu Ser Lys Asp Ala Ile Gly Asp Leu Phe
355 360 365Ser Gln Ile Thr Glu Ser Ala His Thr Glu Glu Glu Leu Ser Ser Lys
370 375 380Val Glu Gln Leu Ser Arg Asn Ala Asp Asp Val Lys Ser Ile Leu Asp385 390 395 400Ile Ile Asn Asp Ile Ala Asp Gln Thr Asn Leu Leu Ala Leu Asn Ala
405 410 415Ala Ile Glu Ala Ala Arg Ala Gly Glu His Gly Arg Gly Phe Ala Val
420 425 430Val Ala Asp Glu Val Arg Asn Leu Ala Gly Arg Thr Gln Lys Ser Leu
435 440 445Ala Glu Ile Asn Ser Thr Ile Met Val Ile Val Gln Glu Ile Asn Ala
450 455 460Val Ser Ser Gln Met Asn Leu Asn Ser Gln Lys Met Glu Arg Leu Ser465 470 475 480Asp Met Ser Lys Ser Val Gln Glu Thr Tyr Glu Lys Met Ser Ser Asn
485 490 495Leu Ser Ser Val Val Ser Asp Ser Asn Gln Ser Met Asp Asp Tyr Ala
500 505 510Lys Ser Gly His Gln Ile Glu Val Met Val Ser Asp Phe Ala Glu Val
515 520 525Glu Lys Val Ala Ser Lys Thr Leu Ala Asp Ser Ser Asp Ile LeuAsn
530 535 540Ile Ala Thr His Val Ser Gly Thr Thr Met Asn Leu Asp Lys Gln Val545 550 555 560Asn Leu Phe Lys Thr
565
(2) Sequence 1197 data:
(i) sequence characteristics:
(A) length: 525bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...474
(D) Other information:
(xi) Description of the sequence: sequence 1197: CCTTGAGATT GCTCT ATG GAA GCA TTC ATC ATG CTC GCT ATA TCA GTG GCT 51
Met Glu Ala Phe Ile Met Leu Ala Ile Ser Val Ala
1 5 10TTA TTT TTC ACG GAA TTT AGG GTG GTT GAG GAA TCT TTC ATG CTC TTT 99Leu Phe Phe Thr Glu Phe Arg Val Val Glu Glu Ser Phe Met Leu Phe
15 20 25TGG GTT TCT TGC GTG ATT TGG ACT AAT TTA TCC ATT GAA GTT TTA TTG 147Trp Val Ser Cys Val Ile Trp Thr Asn Leu Ser Ile Glu Val Leu Leu
30 35 40AGG GTG GAA ATC CCT TTA ATC TCT TCC ATA ATC AAG CGG GCG TTT TCC 195Arg Val Glu Ile Pro Leu Ile Ser Ser Ile Ile Lys Arg Ala Phe Ser45 50 55 60ACA AAC AAA TTG ATC CCA CGG CCC ACT TGC GAG ATT TCA TCG TTGCGA 243Thr Asn Lys Leu Ile Pro Arg Pro Thr Cys Glu Ile Ser Ser Leu Arg
65 70 75TCA CCC ACA TCA ATT TTG GCT CTC AAA TCC TTA TCC CCA CGG CTA AAA 291Ser Pro Thr Ser Ile Leu Ala Leu Lys Ser Leu Ser Pro Arg Leu Lys
80 85 90GCG TTG ATT TTA AGG ACC AGT TCA TCA ATG CGT TTC ACG ATC CTT AAT 339Ala Leu Ile Leu Arg Thr Ser Ser Ser Met Arg Phe Thr Ile Leu Asn
95 100 105TTA GCG TAT ATG AGC GTC AAA ACC ACT AGC GCT ATC GTC GCT GTC AGT 387Leu Ala Tyr Met Ser Val Lys Thr Thr Ser Ala Ile Val Ala Val Ser
110 115 120ATC CAA AGG AAT AAT TTC GTG GTG TTT TCA TCA AAA ACC TTA TTC ACG 435Ile Gln Arg Asn Asn Phe Val Val Phe Ser Ser Lys Thr Leu Phe Thr125 130 135 140CCT TCT TTG ATC GCT TTA TTT TCT GTG TTA ATG TCA GTG TAATAGGAAG TC 486Pro Ser Leu Ile Ala Leu Phe Ser Val Leu Met Ser Val
145 150GTTGCGATCA CCATTTGAGA AACTTCATCA TAATGCGAG 525
(2) Sequence 1198 data:
(i) sequence characteristics:
(A) length: 153 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1198: met Glu Ala Phe Ile Met Leu Ala Ile Ser Val Ala Leu Phe Phe Thr 151015 Glu Phe Arg Val Val Glu Glu Ser Phe Met Leu Phe Trp Val Ser Cys
20 2530Val Ile Trp Thr Asn Leu Ser Ile Glu Val Leu Leu Arg Val Glu Ile
35 40 45Pro Leu Ile Ser Ser Ile Ile Lys Arg Ala Phe Ser Thr Asn Lys Leu
50 55 60Ile Pro Arg Pro Thr Cys Glu Ile Ser Ser Leu Arg Ser Pro Thr Ser65 70 75 80Ile Leu Ala Leu Lys Ser Leu Ser Pro Arg Leu Lys Ala Leu Ile Leu
85 90 95Arg Thr Ser Ser Ser Met Arg Phe Thr Ile Leu Asn Leu Ala Tyr Met
100 105 110Ser Val Lys Thr Thr Ser Ala Ile Val Ala Val Ser Ile Gln Arg Asn
115 120 125Asn Phe Val Val Phe Ser Ser Lys Thr Leu Phe Thr Pro Ser Leu Ile
130 135 140Ala Leu Phe Ser Val Leu Met Ser Val145 150
(2) Sequence 1199 data:
(i) sequence characteristics:
(A) length: 1209bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 25...1164
(D) Other information:
(xi) Description of the sequence: sequence 1199: AAATTCAATA AAAAAGGAAA AACC ATG CGC ATG CAA ACC AAA TTA ATC CAT 51
Met Arg Met Gln Thr Lys Leu Ile His
1 5GGG GGC ATT AGT GAG GAC GCA ACA ACG GGG GCG GTG AGC GTG CCT ATT 99Gly Gly Ile Ser Glu Asp Ala Thr Thr Gly Ala Val Ser Val Pro Ile10 15 20 25TAT CAA ACT TCC ACC TAC CGC CAA GAC GCC ATA GGC CGC CAT AAG GGC 147Tyr Gln Thr Ser Thr Tyr Arg Gln Asp Ala Ile Gly Arg His Lys Gly
30 35 40TAT GAA TAC TCT CGC TCA GGC AAC CCC ACG CGC TTT GCT TTA GAA GAA 195Tyr Glu Tyr Ser Arg Ser Gly Asn Pro Thr Arg Phe Ala Leu Glu Glu
45 50 55CTC ATC GCT GAT TTA GAA GGG GGG GTT AAG GGG TTT GCT TTT GCC TCT 243Leu Ile Ala Asp Leu Glu Gly Gly Val Lys Gly Phe Ala Phe Ala Ser
60 65 70GGA TTA GCT GGA ATC CAC GCC GTT TTT TCC CTC TTG CAA TCA GGC GAT 291Gly Leu Ala Gly Ile His Ala Val Phe Ser Leu Leu Gln Ser Gly Asp
75 80 85CAT GTG TTA TTG GGC GAT GAT GTT TAT GGG GGG ACT TTC CGC TTG TTT 339His Val Leu Leu Gly Asp Asp Val Tyr Gly Gly Thr Phe Arg Leu Phe90 95 100 105AAT CAA GTG CTT GTC AAA AAC GGG CTT TCT TGC ACC ATT ATA GAC ACT 387Asn Gln Val Leu Val Lys Asn Gly Leu Ser Cys Thr Ile Ile Asp Thr
110 115 120AGC GAT ATA TCC CAA ATT AAA AAG GCT ATC AAG CCC AAC ACC AAA GCC 435Ser Asp Ile Ser Gln Ile Lys Lys Ala Ile Lys Pro Asn Thr Lys Ala
125 130 135CTT TAT TTA GAA ACC CCT AGT AAC CCC TTG CTT AAA ATC ACG GAT TTA 483Leu Tyr Leu Glu Thr Pro Ser Asn Pro Leu Leu Lys Ile Thr Asp Leu
140 145150GCG CAA TGC GCT AGT GTC GCT AAA GAT CAT GGT TTG CTC ACT ATC GTG 531Ala Gln Cys Ala Ser Val Ala Lys Asp His Gly Leu Leu Thr Ile Val
155 160 165GAT AAC ACC TTT GCC ACC CCC TAT TAT CAA AAC CCG CTT CTT TTG GGA 579Asp Asn Thr Phe Ala Thr Pro Tyr Tyr Gln Asn Pro Leu Leu Leu Gly170 175 180 185GCG GAC ATT GTG GCA CAT AGC GGC ACC AAA TAC TTA GGC GGG CAT AGC 627Ala Asp Ile Val Ala His Ser Gly Thr Lys Tyr Leu Gly Gly His Ser
190 195 200GAT GTG GTC GCC GGG CTT GTA ACC ACT AAT AAT GAA GCG CTA GCC CAA 675Asp Val Val Ala Gly Leu Val Thr Thr Asn Asn Glu Ala Leu Ala Gln
205 210 215GAG ATC GCT TTT TTC CAA AAC GCT ATC GGT GGG GTT TTA GGC CCT CAA 723Glu Ile Ala Phe Phe Gln Asn Ala Ile Gly Gly Val Leu Gly Pro Gln
220 225 230GAC AGC TGG CTG TTG CAA AGA GGG ATT AAA ACG CTG GGA TTG CGC ATG 771Asp Ser Trp Leu Leu Gln Arg Gly Ile Lys Thr Leu Gly Leu Arg Met
235 240 245GAA GCC CAT CAA AAA AAC GCT CTT TGT GTG GCT GAG TTT TTA GAA AAA 819Glu Ala His Gln Lys Asn Ala Leu Cys Val Ala Glu Phe Leu Glu Lys250 255 260 265CAC CCT AAA GTG GAA AGG GTT TAT TAC CCG GGC CTT CCC ACT CAC CCT 867His Pro Lys Val Glu Arg Val Tyr Tyr Pro Gly Leu Pro Thr His Pro
270 275 280AAT TAC GAA CTA GCT AAA AAA CAG ATG CGT GGC TTT AGC GGG ATG CTC 915Asn Tyr Glu Leu Ala Lys Lys Gln Met Arg Gly Phe Ser Gly Met Leu
285 290 295TCT TTC ACT CTC AAA AAT GAT AGC GAG GCG GTT GCT TTT GTA GAA AGC963Ser Phe Thr Leu Lys Asn Asp Ser Glu Ala Val Ala Phe Val Glu Ser
300 305 310CTT AAA CTA TTC ATT TTA GGC GAG AGT TTG GGC GGG GTG GAA AGT TTG 1011Leu Lys Leu Phe Ile Leu Gly Glu Ser Leu Gly Gly Val Glu Ser Leu
315 320 325GTG GGG ATT CCG GCA TTT ATG ACC CAT GCG TGC ATC CCT AAA ACG CAA 1059Val Gly Ile Pro Ala Phe Met Thr His Ala Cys Ile Pro Lys Thr Gln330 335 340 345CGA GAA GCT GCT GGG ATT AGA GAT GGC CTG GTG CGC TTG TCT GTA GGG 1107Arg Glu Ala Ala Gly Ile Arg Asp Gly Leu Val Arg Leu Ser Val Gly
350 355 360ATT GAG CAT GAA CAG GAT TTG TTA GAA GAT TTA GAG CAA GCG TTC GCT 1155Ile Glu His Glu Gln Asp Leu Leu Glu Asp Leu Glu Gln Ala Phe Ala
365 370 375AAA ATA GGC TAAAGTTTCA TTACAATTTA TGAATAAAGG AGTTAAAAAC ATGAA 1209Lys Ile Gly
380
(2) Sequence 1200 data:
(i) sequence characteristics:
(A) length: 380 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1200: met Arg Met Gln Thr Lys Leu Ile His Gly Gly Ile Ser Glu Asp Ala 151015 Thr Thr Gly Ala Val Ser Val Pro Ile Tyr Gln Thr Ser Thr Tyr Arg
20 25 30Gln Asp Ala Ile Gly Arg His Lys Gly Tyr Glu Tyr Ser Arg Ser Gly
3540 45Asn Pro Thr Arg Phe Ala Leu Glu Glu Leu Ile Ala Asp Leu Glu Gly
50 55 60Gly Val Lys Gly Phe Ala Phe Ala Ser Gly Leu Ala Gly Ile His Ala65 70 75 80Val Phe Ser Leu Leu Gln Ser Gly Asp His Val Leu Leu Gly Asp Asp
85 90 95Val Tyr Gly Gly Thr Phe Arg Leu Phe Asn Gln Val Leu Val Lys Asn
100 105 110Gly Leu Ser Cys Thr Ile Ile Asp Thr Ser Asp Ile Ser Gln Ile Lys
115 120 125Lys Ala Ile Lys Pro Asn Thr Lys Ala Leu Tyr Leu Glu Thr Pro Ser
130 135 140Asn Pro Leu Leu Lys Ile Thr Asp Leu Ala Gln Cys Ala Ser Val Ala145 150 155 160Lys Asp His Gly Leu Leu Thr Ile Val Asp Asn Thr Phe Ala Thr Pro
165 170 175Tyr Tyr Gln Asn Pro Leu Leu Leu Gly Ala Asp Ile Val Ala His Ser
180 185 190Gly Thr Lys Tyr Leu Gly Gly His Ser Asp Val Val Ala Gly Leu Val
195 200 205Thr Thr Asn Asn Glu Ala Leu Ala Gln Glu Ile Ala Phe Phe Gln Asn
210 215 220Ala Ile Gly Gly Val Leu Gly Pro Gln Asp Ser Trp Leu Leu Gln Arg225 230 235 240Gly Ile Lys Thr Leu Gly Leu Arg Met Glu Ala His Gln Lys Asn Ala
245 250 255Leu Cys Val Ala Glu Phe Leu Glu Lys His Pro Lys Val Glu Arg Val
260 265 270Tyr Tyr Pro Gly Leu Pro Thr His Pro Asn Tyr Glu Leu Ala Lys Lys
275 280 285Gln Met Arg Gly Phe Ser Gly Met Leu Ser Phe Thr Leu Lys Asn Asp
290 295 300Ser Glu Ala Val Ala Phe Val Glu Ser Leu Lys Leu Phe Ile Leu Gly305 310 315 320Glu Ser Leu Gly Gly Val Glu Ser Leu Val Gly Ile Pro Ala Phe Met
325 330 335Thr His Ala Cys Ile Pro Lys Thr Gln Arg Glu Ala Ala Gly Ile Arg
340 345 350Asp Gly Leu Val Arg Leu Ser Val Gly Ile Glu His Glu Gln Asp Leu
355 360 365Leu Glu Asp Leu Glu Gln Ala Phe Ala Lys Ile Gly
370 375 380
(2) Sequence 1201 data:
(i) sequence characteristics:
(A) length: 912bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 46...873
(D) Other information:
(xi) Description of the sequence: sequence 1201: ATTATTAACT TTTTATGCTA TAATGCGAGG GTTCTTTCAT CAAGA ATG GTG ATT GAC 57
Met Val Ile Asp
1GAG ATT TTT CAA ATA ATG ATG TTA AGA AGA ATT AAA GTA GGT TCT AAT 105Glu Ile Phe Gln Ile Met Met Leu Arg Arg Ile Lys Val Gly Ser Asn 5 10 15 20TTG AAT AAA AAA GAG AGT TTG TTA GAT GCG TTT GTT AAA ACC TAT CTG 153Leu Asn Lys Lys Glu Ser Leu Leu Asp Ala Phe Val Lys Thr Tyr Leu
25 30 35CAG ATT TTA GAA CCC ATT AGT TCT AAA CGC TTA AAA GAG TTG GCG GAC 201Gln Ile Leu Glu Pro Ile Ser Ser Lys Arg Leu Lys Glu Leu Ala Asp
40 45 50TTG AAA ATA TCT TGC GCG ACG ATC AGG AAT TAT TTT CAA ATC CTT TCT 249Leu Lys Ile Ser Cys Ala Thr Ile Arg Asn Tyr Phe Gln Ile Leu Ser
55 60 65AAA GAG GGC ATG CTT TAT CAA GCC CAT TCT AGT GGC GCT AGA TTG CCC 297Lys Glu Gly Met Leu Tyr Gln Ala His Ser Ser Gly Ala Arg Leu Pro
70 75 80ACT TTT AAG GCG TTT GAA AAC TAT TGG CAA AAG TCG TTG CGC TTT GAA 345Thr Phe Lys Ala Phe Glu Asn Tyr Trp Gln Lys Ser Leu Arg Phe Glu85 90 95 100ACT TTA AAG GTG AAT GAA AAA CGC CTA AAA AGC GCG AGT GAA AAT TTT 393Thr Leu Lys Val Asn Glu Lys Arg Leu Lys Ser Ala Ser Glu Asn Phe
105 110 115GGG CTT TTC ACG CTG TTA AAA AAA CCC AGT TTG GAG CGT TTA GAA AGA 441Gly Leu Phe Thr Leu Leu Lys Lys Pro Ser Leu Glu Arg Leu Glu Arg
120 125 130GTC ATT GAG TGC GAA AAA CGC TTT TTG ATT TTG GAC TTT TTG GCG TTT 489Val Ile Glu Cys Glu Lys Arg Phe Leu Ile Leu Asp Phe Leu Ala Phe
135 140 145TCT TGC GCA CTG GGT TAC AGC GTT AAA ATG GAA AAG TTT TTA TTA GAG 537Ser Cys Ala Leu Gly Tyr Ser Val Lys Met Glu Lys Phe Leu Leu Glu
150 155 160CTT GTG GGC AGA AGC GTT AAA GAA GTG CGC TCA ATC GCT GCT TCT TTC 585Leu Val Gly Arg Ser Val Lys Glu Val Arg Ser Ile Ala Ala Ser Phe165 170 175 180AAT GCG TTG AGT TTG GCC AGG CAA TTA GAG CGT TTG GAG TAT TCC AAC 633Asn Ala Leu Ser Leu Ala Arg Gln Leu Glu Arg Leu Glu Tyr Ser Asn
185 190 195ACA CAA ATC ACA CGC TTT AAT CTG ATG GGG TTA AAA ACG CTT TTA AAC 681Thr Gln Ile Thr Arg Phe Asn Leu Met Gly Leu Lys Thr Leu Leu Asn
200 205 210AGC CCT TTA TTT TTT GAC ATT TTA GGG GGT AAG GTT TTA GAG CGT TTG 729Ser Pro Leu Phe Phe Asp Ile Leu Gly Gly Lys Val Leu Glu Arg Leu
215 220 225AGT AAG GGT TTG CAT TTT ATA GAG CCT GAT TGC ATG CTA GTA ACA CGC 777Ser Lys Gly Leu His Phe Ile Glu Pro Asp Cys Met Leu Val Thr Arg
230 235 240CCT GTA GAA TTT CAA AAC AAG CGG ATG CAA CTG CTT TGC GTG GGG AAA 825Pro Val Glu Phe Gln Asn Lys Arg Met Gln Leu Leu Cys Val Gly Lys245 250 255 260CTA GAA TGC GAT TAT GAA GGG TTT TTT CAA ACG ATT TCT GAG GAG GAA T 874Leu Glu Cys Asp Tyr Glu Gly Phe Phe Gln Thr Ile Ser Glu Glu Glu
265 270 275AATGAAAGAT GAACACAACC AAGAACACGA TCATTTAA 912
(2) Sequence 1202 data:
(i) sequence characteristics:
(A) length: 276 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1202: met Val Ile Asp Glu Ile Phe Gln Ile Met Met Leu Arg Arg Ile Lys 151015 Val Gly Ser Asn Leu Asn Lys Lys Glu Ser Leu Leu Asp Ala Phe Val
20 25 30Lys Thr Tyr Leu Gln Ile Leu Glu Pro Ile Ser Ser Lys Arg Leu Lys
35 40 45Glu Leu Ala Asp Leu Lys Ile Ser Cys Ala Thr Ile Arg Asn Tyr Phe
50 55 60Gln Ile Leu Ser Lys Glu Gly Met Leu Tyr Gln Ala His Ser Ser Gly65 70 75 80Ala Arg Leu Pro Thr Phe Lys Ala Phe Glu Asn Tyr Trp Gln Lys Ser
85 90 95Leu Arg Phe Glu Thr Leu Lys Val Asn Glu Lys Arg Leu Lys Ser Ala
100 105 110Ser Glu Asn Phe Gly Leu Phe Thr Leu Leu Lys Lys Pro Ser Leu Glu
115 120 125Arg Leu Glu Arg Val Ile Glu Cys Glu Lys Arg Phe Leu Ile Leu Asp
130 135 140Phe Leu Ala Phe Ser Cys Ala Leu Gly Tyr Ser Val Lys Met Glu Lys145 150 155 160Phe Leu Leu Glu Leu Val Gly Arg Ser Val Lys Glu Val Arg Ser Ile
165 170 175Ala Ala Ser Phe Asn Ala Leu Ser Leu Ala Arg Gln Leu Glu Arg Leu
180 185 190Glu Tyr Ser Asn Thr Gln Ile Thr Arg Phe Asn Leu Met Gly Leu Lys
195 200 205Thr Leu Leu Asn Ser Pro Leu Phe Phe Asp Ile Leu Gly Gly Lys Val
210 215 220Leu Glu Arg Leu Ser Lys Gly Leu His Phe Ile Glu Pro Asp Cys Met225 230 235 240Leu Val Thr Arg Pro Val Glu Phe Gln Asn Lys Arg Met Gln Leu Leu
245 250 255Cys Val Gly Lys Leu Glu Cys Asp Tyr Glu Gly Phe Phe Gln Thr Ile
260 265 270Ser Glu Glu Glu
275
(2) Sequence 1203 data:
(i) sequence characteristics:
(A) length: 720bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...685
(D) Other information:
(xi) Description of the sequence: sequence 1203: AGCTCTTTAC TATTTTATTA TCTATCTTTT ATTAAAAAAA CTTGTTATC ATG ATA AAC 58
Met Ile Asn
1ATG AAC ACA CAC ACA AGA GGC ATT GAC AGC AAT CTG ATT CAT TCG CTC 106Met Asn Thr His Thr Arg Gly Ile Asp Ser Asn Leu Ile His Ser Leu
5 10 15CAA AGC ATT TCA TTA TCC ATGTTT AGA AAG GGT TTT TTT GGG CTT TAT 154Gln Ser Ile Ser Leu Ser Met Phe Arg Lys Gly Phe Phe Gly Leu Tyr20 25 30 35CAA GGC TCT ATT TCA GCA CGC ATT GGC GCA AAT CAA TTT GTG ATC AAC 202Gln Gly Ser Ile Ser Ala Arg Ile Gly Ala Asn Gln Phe Val Ile Asn
40 45 50AAA AGA AAC GCT GTT TTT GAT CAA TTG AAT GAA AAC ACC TTA CTG GTT 250Lys Arg Asn Ala Val Phe Asp Gln Leu Asn Glu Asn Thr Leu Leu Val
55 60 65TTG CAT GAC AAA ATA GAT TAC CGC TGG AAA GAA GCG AGC TTG GAT TCG 298Leu His Asp Lys Ile Asp Tyr Arg Trp Lys Glu Ala Ser Leu Asp Ser
70 75 80CCC ATT CAT GCG AGC GTG TAT AGG GAG TTT TTG GAC GCT AAA TTC ATC 346Pro Ile His Ala Ser Val Tyr Arg Glu Phe Leu Asp Ala Lys Phe Ile
85 90 95GCT TAC GCG CGC CCT CCT TAT AGT TTG GCG TAT TCC TTG CGC CAC AAC 394Ala Tyr Ala Arg Pro Pro Tyr Ser Leu Ala Tyr Ser Leu Arg His Asn100 105 110 115CGA TTG CTC CCT AGA GAT TAT TTA GGG TAT CGT TCT TTG GGC GAA GAA 442Arg Leu Leu Pro Arg Asp Tyr Leu Gly Tyr Arg Ser Leu Gly Glu Glu
120 125 130ATT TCC ATT TTT AAC CCC AAA GAC TAT GAC AGC TGG CAA GAA AGA GCG 490Ile Ser Ile Phe Asn Pro Lys Asp Tyr Asp Ser Trp Gln Glu Arg Ala
135 140 145GAT ACA GAA ATT TTA CGC CAA CTG CAA GAG AGC AAA AAA TAT TTT GTT 538Asp Thr Glu Ile Leu Arg Gln Leu Gln Glu Ser Lys Lys Tyr Phe Val
150 155 160TTC ATT AAG GGG TGT GGG ATT TTT GCC TAC CAC AGA GAG CTT TCT AAA 586Phe Ile Lys Gly Cys Gly IlePhe Ala Tyr His Arg Glu Leu Ser Lys
165 170 175CTC ATG GAA GTT TTT GAT TTG ATT GAA AAC TCA TGC AAG GTT TTA CGA 634Leu Met Glu Val Phe Asp Leu Ile Glu Asn Ser Cys Lys Val Leu Arg180 185 190 195TTG GGC GAT TTA ATG GAT TAT TGC TAT AAT GAT GAT CCA CGA TTG AGC 682Leu Gly Asp Leu Met Asp Tyr Cys Tyr Asn Asp Asp Pro Arg Leu Ser
200 205 210GTG TAAAAAGCTA AAAAGGATAA AACATGACCA TCAAC 720Val
(2) Sequence 1204 data:
(i) sequence characteristics:
(A) length: 212 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1204: met Ile Asn Met Asn Thr His Thr Arg Gly Ile Asp Ser Asn Leu Ile 151015 His Ser Leu Gln Ser Ile Ser Leu Ser Met Phe Arg Lys Gly Phe Phe
20 25 30Gly Leu Tyr Gln Gly Ser Ile Ser Ala Arg Ile Gly Ala Asn Gln Phe
35 40 45Val Ile Asn Lys Arg Asn Ala Val Phe Asp Gln Leu Asn Glu Asn Thr
50 55 60Leu Leu Val Leu His Asp Lys Ile Asp Tyr Arg Trp Lys Glu Ala Ser65 70 75 80Leu Asp Ser Pro Ile His Ala Ser Val Tyr Arg Glu Phe Leu Asp Ala
85 90 95Lys Phe Ile Ala Tyr Ala Arg Pro Pro Tyr Ser Leu Ala Tyr Ser Leu
100 105 110Arg His Asn Arg Leu Leu Pro Arg Asp Tyr Leu Gly Tyr Arg Ser Leu
115 120 125Gly Glu Glu Ile Ser Ile Phe Asn Pro Lys Asp Tyr Asp Ser Trp Gln
130 135 140Glu Arg Ala Asp Thr Glu Ile Leu Arg Gln Leu Gln Glu Ser Lys Lys145 150 155 160Tyr Phe Val Phe Ile Lys Gly Cys Gly Ile Phe Ala Tyr His Arg Glu
165 170 175Leu Ser Lys Leu Met Glu Val Phe Asp Leu Ile Glu Asn Ser Cys Lys
180 185 190Val Leu Arg Leu Gly Asp Leu Met Asp Tyr Cys Tyr Asn Asp Asp Pro
195 200 205Arg Leu Ser Val
210
(2) Sequence 1205 data:
(i) sequence characteristics:
(A) length: 2498bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 91...2445
(D) Other information:
(xi) Description of the sequence: sequence 1205: GGGAGTTTTG TGCGATATAT CAAGTTTTTC AAAGAGTTGA ACAATAAAAA TGTGAATCTG 60GTTGGGGGCA AGAACGCTAG TATTGGTGAA ATG TTT CAA GAA TTA GTG CCT ATT 114
Met Phe Gln Glu Leu Val Pro Ile
1 5GGT ATT AAA GTG CCT GAT GGC TTT GCG ATC ACC AGC GAA GCG TAT TGG 162Gly Ile Lys Val Pro Asp Gly Phe Ala Ile Thr Ser Glu Ala Tyr Trp
10 15 20TAT CTT TTA GAG CAA GGA GGG GCT AAA CAA AAA ATC ATA GAG CTT TTA 210Tyr Leu Leu Glu Gln Gly Gly Ala Lys Gln Lys Ile Ile Glu Leu Leu25 30 35 40GAA AAT GTT GAT GCC ACC GAA ATT GAT GTG TTA AAA ATC CGC TCC AAA 258Glu Asn Val Asp Ala Thr Glu Ile Asp Val Leu Lys Ile Arg Ser Lys
45 50 55CAA ATC AGA GAG CTT ATT TTT GGC ACG CCT TTT CCT AGC GAT TTG AGA 306Gln Ile Arg Glu Leu Ile Phe Gly Thr Pro Phe Pro Ser Asp Leu Arg
60 65 70GAT GAG ATT TTT CAA GCT TAT GAG ATT TTA AGC CAG CAA TAC CAC ATG 354Asp Glu Ile Phe Gln Ala Tyr Glu Ile Leu Ser Gln Gln Tyr His Met
75 80 85AAA GAA GCC GAT GTG GCT GTA AGG AGT TCC GCT ACT GCA GAA GAT TTG 402Lys Glu Ala Asp Val Ala Val Arg Ser Ser Ala Thr Ala Glu Asp Leu
90 95 100CCG GAC GCT TCT TTT GCC GGG CAG CAA GAC ACT TAT TTA AAC ATT AAG 450Pro Asp Ala Ser Phe Ala Gly Gln Gln Asp Thr Tyr Leu Asn Ile Lys105 110 115 120GGT AAA ACC GAA TTG ATC CAC TAT ATC AAA TCC TGT TTA GCG TCG CTT 498Gly Lys Thr Glu Leu Ile His Tyr Ile Lys Ser Cys Leu Ala Ser Leu
125 130 135TTT ACC GAT AGA GCG ATT AGC TAT AGG GCG AGT CGT GGG TTT GAT CAT 546Phe Thr Asp Arg Ala Ile Ser Tyr Arg Ala Ser Arg Gly Phe Asp His
140 145150TTA AAA GTC GCG CTC AGC GTG GGG GTG CAA AAA ATG GTG CGA GCG GAT 594Leu Lys Val Ala Leu Ser Val Gly Val Gln Lys Met Val Arg Ala Asp
155 160 165AAA GGC AGC GCG GGC GTG ATG TTT TCT ATT GAC ACC GAA ACC GGT TTT 642Lys Gly Ser Ala Gly Val Met Phe Ser Ile Asp Thr Glu Thr Gly Phe
170 175 180AAA GAC GCG GTG TTT ATC ACT TCA GCG TGG GGG TTA GGC GAA AAT GTG 690Lys Asp Ala Val Phe Ile Thr Ser Ala Trp Gly Leu Gly Glu Asn Val185 190 195 200GTG GGT GGC ACG ATA AAC CCT GAT GAA TTT TAT GTG TTT AAG CCC ACT 738Val Gly Gly Thr Ile Asn Pro Asp Glu Phe Tyr Val Phe Lys Pro Thr
205 210 215TTA GAG CAA AAC AAA CGC CCC ATT ATC AAA CGC CAA CTC GGC AAT AAA 786Leu Glu Gln Asn Lys Arg Pro Ile Ile Lys Arg Gln Leu Gly Asn Lys
220 225 230ACG CAA AAA ATG GTC TAT GCC CCA AGG GGT AGC GAA CAC CCC ACC AGA 834Thr Gln Lys Met Val Tyr Ala Pro Arg Gly Ser Glu His Pro Thr Arg
235 240 245AAC ATT AAA ACC ACC AAA AAA GAA TGG CAA TCC TTT TCA TTG AGC GAT 882Asn Ile Lys Thr Thr Lys Lys Glu Trp Gln Ser Phe Ser Leu Ser Asp
250 255 260GAA GAC GTG CTG ATT TTA GCC AAA TAC GCC ATT GAA ATT GAA AAA CAC 930Glu Asp Val Leu Ile Leu Ala Lys Tyr Ala Ile Glu Ile Glu Lys His265 270 275 280TAC TCT AAA GAA GCC AAA CAA TAC CGC CCT ATG GAT ATA GAA TGG GCT 978Tyr Ser Lys Glu Ala Lys Gln Tyr Arg Pro Met Asp Ile Glu Trp Ala
285 290 295AAA GAT GGC GAG AGC GGG GAA ATC TTT ATC GTT CAA GCG CGC CCA GAA 1026Lys Asp Gly Glu Ser Gly Glu Ile Phe Ile Val Gln Ala Arg Pro Glu
300 305 310ACC GTT CAA AGC CAA AAA AGT AAA GAA GAA AGT CAA GTC TTT GAA AAA 1074Thr Val Gln Ser Gln Lys Ser Lys Glu Glu Ser Gln Val Phe Glu Lys
315 320 325TTC AAA TTC AAA AAC CCT AAC GAA AAG AAA GAG ATT ATC TTA CAA GGC 1122Phe Lys Phe Lys Asn Pro Asn Glu Lys Lys Glu Ile Ile Leu Gln Gly
330 335 340AGA GCG ATT GGG AGT AAA ATT GGC TCA GGA AAA GTG CGC ATC ATC AAT 1170Arg Ala Ile Gly Ser Lys Ile Gly Ser Gly Lys Val Arg Ile Ile Asn345 350 355 360GAT TTG GAG CAC ATG AAT TCT TTT AAA GAG GGC GAA ATT TTA GTT ACG 1218Asp Leu Glu His Met Asn Ser Phe Lys Glu Gly Glu Ile Leu Val Thr
365 370 375GAT AAC ACC GAT CCG GAC TGG GAG CCT TGC ATG AAA AAA GCG AGC GCG 1266Asp Asn Thr Asp Pro Asp Trp Glu Pro Cys Met Lys Lys Ala Ser Ala
380 385 390GTT ATC ACT AAT CGT GGA GGG CGC ACT TGC CAT GCC GCT ATT GTG GCG 1314Val Ile Thr Asn Arg Gly Gly Arg Thr Cys His Ala Ala Ile Val Ala
395 400 405AGA GAA ATT GGC GTG CCA GCT ATC GTT GGG GTG AGC GGG GCG ACT GAT 1362Arg Glu Ile Gly Val Pro Ala Ile Val Gly Val Ser Gly Ala Thr Asp
410 415 420AGC CTT TAT ACC GGC ATG GAA ATC ACG GTT TCT TGC GCT GAG GGC GAA 1410Ser Leu Tyr Thr Gly Met Glu Ile Thr Val Ser Cys Ala Glu Gly Glu425 430 435 440GAG GGC TAT GTG TAT GCG GGC ATT TAT GAG CAT GAA ATT GAA AGG GTG 1458Glu Gly Tyr Val Tyr Ala Gly Ile Tyr Glu His Glu Ile Glu Arg Val
445 450 455GAG CTT TCT AAC ATG CAA GAA ACT CAA ACA AAA ATT TAC ATC AAT ATT 1506Glu Leu Ser Asn Met Gln Glu Thr Gln Thr Lys Ile Tyr Ile Asn Ile
460 465 470GGA AAC CCT GAA AAA GCC TTT GGC TTT TCT CAA CTC CCT AAT CAC GGC 1554Gly Asn Pro Glu Lys Ala Phe Gly Phe Ser Gln Leu Pro Asn His Gly
475 480 485GTA GGG CTA GCC AGG ATG GAA ATG ATT ATT TTA AAT CAA ATC AAA GCC 1602Val Gly Leu Ala Arg Met Glu Met Ile Ile Leu Asn Gln Ile Lys Ala
490 495 500CAC CCT TTA GCT TTA GTG GAT TTG CAC CAC AAA AAA AGC GTG AAA GAA 1650His Pro Leu Ala Leu Val Asp Leu His His Lys Lys Ser Val Lys Glu505 510 515 520AAA AAT GAA ATT GAA AAC CTC ATG GCA GGC TAT GCT AAC CCT AAA GAT 1698Lys Asn Glu Ile Glu Asn Leu Met Ala Gly Tyr Ala Asn Pro Lys Asp
525 530 535TTT TTT GTG AAA AAA ATC GCT GAA GGC ATT GGC ATG ATC AGT GCA GCG 1746Phe Phe Val Lys Lys Ile Ala Glu Gly Ile Gly Met Ile Ser Ala Ala
540 545 550TTT TAC CCT AAA CCT GTC ATT GTG AGA ACG AGC GAT TTC AAA TCC AAT 1794Phe Tyr Pro Lys Pro Val Ile Val Arg Thr Ser Asp Phe Lys Ser Asn
555 560 565GAA TAC ATG CGC ATG CTT GGC GGC TCT AGC TAT GAG CCT AAT GAA GAA 1842Glu Tyr Met Arg Met Leu Gly Gly Ser Ser Tyr Glu Pro Asn Glu Glu
570 575 580AAC CCC ATG CTT GGC TAT AGG GGG GCT AGT CGG TAT TAT TCA GAG AGC 1890Asn Pro Met Leu Gly Tyr Arg Gly Ala Ser Arg Tyr Tyr Ser Glu Ser585 590 595 600TAT AAT GAA GCG TTTTCG TGG GAG TGT GAA GCC TTA GCG TTA GTG AGG 1938Tyr Asn Glu Ala Phe Ser Trp Glu Cys Glu Ala Leu Ala Leu Val Arg
605 610 615GAA GAA ATG GGA TTA ACC AAC ATG AAA GTG ATG ATC CCT TTT TTG CGA 1986Glu Glu Met Gly Leu Thr Asn Met Lys Val Met Ile Pro Phe Leu Arg
620 625 630ACC ATT GAA GAG GGT AAA AAA GTC CTA GAA ATC TTA AGA AAA AAC AAT 2034Thr Ile Glu Glu Gly Lys Lys Val Leu Glu Ile Leu Arg Lys Asn Asn
635 640 645TTA GAA TCC GGT AAA AAC GGG CTT GAA ATT TAT ATC ATG TGC GAA TTG 2082Leu Glu Ser Gly Lys Asn Gly Leu Glu Ile Tyr Ile Met Cys Glu Leu
650 655 660CCG GTG AAT GTC ATT TTG GCT GAT GAT TTC TTG AGC TTG TTT GAT GGC 2130Pro Val Asn Val Ile Leu Ala Asp Asp Phe Leu Ser Leu Phe Asp Gly665 670 675 680TTT TCT ATT GGA TCA AAC GAT TTA ACC CAG CTC ACT TTA GGC GTG GAT 2178Phe Ser Ile Gly Ser Asn Asp Leu Thr Gln Leu Thr Leu Gly Val Asp
685 690 695AGA GAC AGC GAA TTG GTC AGC CAT GTC TTT GAT GAA AGG AAT GAA GCG 2226Arg Asp Ser Glu Leu Val Ser His Val Phe Asp Glu Arg Asn Glu Ala
700 705 710ATG CTA AAG ATG TTT AAA AAA GCG ATT GAA GCT TGC AAA AGG CAC AAC 2274Met Leu Lys Met Phe Lys Lys Ala Ile Glu Ala Cys Lys Arg His Asn
715 720 725AAA TAT TGC GGG ATT TGC GGG CAA GCC CCA AGC GAT TAC CCT GAA GTA 2322Lys Tyr Cys Gly Ile Cys Gly Gln Ala Pro Ser Asp Tyr Pro Glu Val
730 735 740ACA GAG TTT TTA GTC AAA GAG GGC ATC ACT TCC ATT TCT TTA AAC CCT 2370Thr Glu Phe Leu Val Lys Glu Gly Ile Thr Ser Ile Ser Leu Asn Pro745 750 755 760GAT AGC GTG ATC CCC ACT TGG AAC GCT GTA GCC AAG TTA GAA AAA GAA 2418Asp Ser Val Ile Pro Thr Trp Asn Ala Val Ala Lys Leu Glu Lys Glu
765 770 775CTA AAA GAA CAT GGC TTA ACT GAA CAT TGATAATAAA TAAATCAATC TAACTTG 2472Leu Lys Glu His Gly Leu Thr Glu His
780 785AGTGGATTTT TCGTATTAGT TTCCAT 2498
(2) Sequence 1206 data:
(i) sequence characteristics:
(A) length: 785 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1206: met Phe Gln Glu Leu Val Pro Ile Gly Ile Lys Val Pro Asp Gly Phe 151015 Ala Ile Thr Ser Glu Ala Tyr Trp Tyr Leu Leu Glu Gln Gly Gly Ala
20 25 30Lys Gln Lys Ile Ile Glu Leu Leu Glu Asn Val Asp Ala Thr Glu Ile
35 40 45Asp Val Leu Lys Ile Arg Ser Lys Gln Ile Arg Glu Leu Ile Phe Gly
50 55 60Thr Pro Phe Pro Ser Asp Leu Arg Asp Glu Ile Phe Gln Ala Tyr Glu65 70 75 80Ile Leu Ser Gln Gln Tyr His Met Lys Glu Ala Asp Val Ala Val Arg
85 90 95Ser Ser Ala Thr Ala Glu Asp Leu Pro Asp Ala Ser Phe Ala Gly Gln
100105 110Gln Asp Thr Tyr Leu Asn Ile Lys Gly Lys Thr Glu Leu Ile His Tyr
115 120 125Ile Lys Ser Cys Leu Ala Ser Leu Phe Thr Asp Arg Ala Ile Ser Tyr
130 135 140Arg Ala Ser Arg Gly Phe Asp His Leu Lys Val Ala Leu Ser Val Gly145 150 155 160Val Gln Lys Met Val Arg Ala Asp Lys Gly Ser Ala Gly Val Met Phe
165 170 175Ser Ile Asp Thr Glu Thr Gly Phe Lys Asp Ala Val Phe Ile Thr Ser
180 185 190Ala Trp Gly Leu Gly Glu Asn Val Val Gly Gly Thr Ile Asn Pro Asp
195 200 205Glu Phe Tyr Val Phe Lys Pro Thr Leu Glu Gln Asn Lys Arg Pro Ile
210 215 220Ile Lys Arg Gln Leu Gly Asn Lys Thr Gln Lys Met Val Tyr Ala Pro225 230 235 240Arg Gly Ser Glu His Pro Thr Arg Asn Ile Lys Thr Thr Lys Lys Glu
245 250 255Trp Gln Ser Phe Ser Leu Ser Asp Glu Asp Val Leu Ile Leu Ala Lys
260 265 270Tyr Ala Ile Glu Ile Glu Lys His Tyr Ser Lys Glu Ala Lys Gln Tyr
275 280 285Arg Pro Met Asp Ile Glu Trp Ala Lys Asp Gly Glu Ser Gly Glu Ile
290 295 300Phe Ile Val Gln Ala Arg Pro Glu Thr Val Gln Ser Gln Lys Ser Lys305 310 315 320Glu Glu Ser Gln Val Phe Glu Lys Phe Lys Phe Lys Asn Pro Asn Glu
325 330 335Lys Lys Glu Ile Ile Leu Gln Gly Arg Ala Ile Gly Ser Lys Ile Gly
340 345 350Ser Gly Lys Val Arg Ile Ile Asn Asp Leu Glu His Met Asn Ser Phe
355 360 365Lys Glu Gly Glu Ile Leu Val Thr Asp Asn Thr Asp Pro Asp Trp Glu
370 375 380Pro Cys Met Lys Lys Ala Ser Ala Val Ile Thr Asn Arg Gly Gly Arg385 390 395 400Thr Cys His Ala Ala Ile Val Ala Arg Glu Ile Gly Val Pro Ala Ile
405 410 415Val Gly Val Ser Gly Ala Thr Asp Ser Leu Tyr Thr Gly Met Glu Ile
420 425 430Thr Val Ser Cys Ala Glu Gly Glu Glu Gly Tyr Val Tyr Ala Gly Ile
435 440 445Tyr Glu His Glu Ile Glu Arg Val Glu Leu Ser Asn Met Gln Glu Thr
450 455 460Gln Thr Lys Ile Tyr Ile Asn Ile Gly Asn Pro Glu Lys Ala Phe Gly465 470 475 480Phe Ser Gln Leu Pro Asn His Gly Val Gly Leu Ala Arg Met Glu Met
485 490 495Ile Ile Leu Asn Gln Ile Lys Ala His Pro Leu Ala Leu Val Asp Leu
500 505 510His His Lys Lys Ser Val Lys Glu Lys Asn Glu Ile Glu Asn Leu Met
515 520 525Ala Gly Tyr Ala Asn Pro Lys Asp Phe Phe Val Lys Lys Ile Ala Glu
530 535 540Gly Ile Gly Met Ile Ser Ala Ala Phe Tyr Pro Lys Pro Val Ile Val545550 555 560Arg Thr Ser Asp Phe Lys Ser Asn Glu Tyr Met Arg Met Leu Gly Gly
565 570 575Ser Ser Tyr Glu Pro Asn Glu Glu Asn Pro Met Leu Gly Tyr Arg Gly
580 585 590Ala Ser Arg Tyr Tyr Ser Glu Ser Tyr Asn Glu Ala Phe Ser Trp Glu
595 600 605Cys Glu Ala Leu Ala Leu Val Arg Glu Glu Met Gly Leu Thr Asn Met
610 615 620Lys Val Met Ile Pro Phe Leu Arg Thr Ile Glu Glu Gly Lys Lys Val625 630 635 640Leu Glu Ile Leu Arg Lys Asn Asn Leu Glu Ser Gly Lys Asn Gly Leu
645 650 655Glu Ile Tyr Ile Met Cys Glu Leu Pro Val Asn Val Ile Leu Ala Asp
660 665 670Asp Phe Leu Ser Leu Phe Asp Gly Phe Ser Ile Gly Ser Asn Asp Leu
675 680 685Thr Gln Leu Thr Leu Gly Val Asp Arg Asp Ser Glu Leu Val Ser His
690 695 700Val Phe Asp Glu Arg Asn Glu Ala Met Leu Lys Met Phe Lys Lys Ala705 710 715 720Ile Glu Ala Cys Lys Arg His Asn Lys Tyr Cys Gly Ile Cys Gly Gln
725 730 735Ala Pro Ser Asp Tyr Pro Glu Val Thr Glu Phe Leu Val Lys Glu Gly
740 745 750Ile Thr Ser Ile Ser Leu Asn Pro Asp Ser Val Ile Pro Thr Trp Asn
755 760 765Ala Val Ala Lys Leu Glu Lys Glu Leu Lys Glu His Gly Leu Thr Glu
770 775 780His785
(2) Sequence 1207 data:
(i) sequence characteristics:
(A) length: 565bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 61...483
(D) Other information:
(xi) Description of the sequence: sequence 1207: GTTATCTTTA ATCAATCAGA TGATAGAATT TATCTTTTAT TTTTGAATTG GGAGCATTTG 60ATG AAA AAA TTA GCG GTT TCT TTA TTA TTT ACA GGG ACT TTT TTG GGG 108Met Lys Lys Leu Ala Val Ser Leu Leu Phe Thr Gly Thr Phe Leu Gly 151015 CTT TTT TTG AAT GCG AGC GAT TTT AAG AGC ATG GAT GAC AAG CAA CTA 156Leu Phe Leu Asn Ala Ser Asp Phe Lys Ser Met Asp Asp Lys Gln Leu
20 25 30TTA GAG CAA GCA GGG AAA GTT GCT CCT AGC GAA GTC CCT GAG TTT CGC 204Leu Glu Gln Ala Gly Lys Val Ala Pro Ser Glu Val Pro Glu Phe Arg
35 40 45GCG GAA GTC AAT AAG CGA TTA GCA GTG ATG AAA GAA GAA GAT CGT AAA 252Ala Glu Val Asn Lys Arg Leu Ala Val Met Lys Glu Glu Asp Arg Lys
50 55 60AAT TAT AAA GCG GAT TTT AAG AAA GCG ATG GAT AAG AAT TTA GCT TCT 300Asn Tyr Lys Ala Asp Phe Lys Lys Ala Met Asp Lys Asn Leu Ala Ser65 70 75 80TTA AGC CAA GAA GAT CGC AAC AAG CGT AAA AAA GAA ATT CTT GAA GCG 348Leu Ser Gln Glu Asp Arg Asn Lys Arg LysLys Glu Ile Leu Glu Ala
85 90 95ATT GCT AAC AAA AAG AAA ACA ATG ACC ATG AAA GAA TAT CGT GAA GAA 396Ile Ala Asn Lys Lys Lys Thr Met Thr Met Lys Glu Tyr Arg Glu Glu
100 105 110GGG TTG GAT TTG CAT GAT TGC GCA TGC GAA GGC CCT TTT CAT GAT CAT 444Gly Leu Asp Leu His Asp Cys Ala Cys Glu Gly Pro Phe His Asp His
115 120 125GAG AGA AAA AAA GGG AAA AAA CCA AGC CAT CAT AAG CAT TAGCGCTTAG GG 495Glu Arg Lys Lys Gly Lys Lys Pro Ser His His Lys His
130 135 140TGTGCTAACT TTTTTTGATT TTTGTGAAAC CACGCCGTAA GTCCCTAGCT TTTGGCTGTG 555GGGATTAAGG 565
(2) Sequence 1208 data:
(i) sequence characteristics:
(A) length: 141 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1208: met Lys Lys Leu Ala Val Ser Leu Leu Phe Thr Gly Thr Phe Leu Gly 151015 Leu Phe Leu Asn Ala Ser Asp Phe Lys Ser Met Asp Asp Lys Gln Leu
20 25 30Leu Glu Gln Ala Gly Lys Val Ala Pro Ser Glu Val Pro Glu Phe Arg
35 40 45Ala Glu Val Asn Lys Arg Leu Ala Val Met Lys Glu Glu Asp Arg Lys
50 55 60Asn Tyr Lys Ala Asp Phe Lys Lys Ala Met Asp Lys Asn Leu Ala Ser65 70 75 80Leu Ser Gln Glu Asp Arg Asn Lys Arg Lys Lys Glu Ile Leu Glu Ala
85 90 95Ile Ala Asn Lys Lys Lys Thr Met Thr Met Lys Glu Tyr Arg Glu Glu
100 105 110Gly Leu Asp Leu His Asp Cys Ala Cys Glu Gly Pro Phe His Asp His
115 120 125Glu Arg Lys Lys Gly Lys Lys Pro Ser His His Lys His
130 135 140
(2) Sequence 1209 data:
(i) sequence characteristics:
(A) length: 558bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...506
(D) Other information:
(xi) Description of the sequence: sequence 1209: GGGTGCATGG GCCTCAAAAA GTCGCTATCA TTCTCTACTA AAGGATAAGA ATG GAA 56
Met Glu
1AAA TTA GAA GTA GGG CAA TTA GCC CCT GAT TTT AGA TTG AAA AAC AGC 104Lys Leu Glu Val Gly Gln Leu Ala Pro Asp Phe Arg Leu Lys Asn Ser
5 10 15GAT GGC GTG GAA ATT TCT TTA AAA GAT TTG CTC CAT AAA AAA GTG GTG 152Asp Gly Val Glu Ile Ser Leu Lys Asp Leu Leu His Lys Lys Val Val
20 25 30CTG TAT TTC TAC CCT AAA GAC AAC ACC CCC GGA TGC ACT CTA GAA GCC 200Leu Tyr Phe Tyr Pro Lys Asp Asn Thr Pro Gly Cys Thr Leu Glu Ala35 40 45 50AAA GAC TTT AGC GCT CTA TTT AGT GAA TTT GAA AAG AAA AAC GCT GTT 248Lys Asp Phe Ser Ala Leu Phe Ser Glu Phe Glu Lys Lys Asn Ala Val
55 60 65GTC GTA GGC ATA AGC CCT GAT AAC GCG CAA TCG CAT CAA AAA TTT ATC 296Val Val Gly Ile Ser Pro Asp Asn Ala Gln Ser His Gln Lys Phe Ile
70 75 80AGC CAA TGC TCT TTG AAT GTG ATT TTG CTC TGC GAT GAA GAT AAA AAA 344Ser Gln Cys Ser Leu Asn Val Ile Leu Leu Cys Asp Glu Asp Lys Lys
85 90 95GCC GCC AAT CTT TAC AAA GCT TAT GGC AAA CGC ATG CTT TAT GGG AAG 392Ala Ala Asn Leu Tyr Lys Ala Tyr Gly Lys Arg Met Leu Tyr Gly Lys
100 105 110GAG CAT TTG GGG ATT ATC CGC TCC ACC TTC ATT ATC AAC ACG CAA GGC 440Glu His Leu Gly Ile Ile Arg Ser Thr Phe Ile Ile Asn Thr Gln Gly115 120 125 130GTT TTA GAA AAA TGT TTC TAC AAT GTC AAA GCG AAA GGC CAT GCT CAA 488Val Leu Glu Lys Cys Phe Tyr Asn Val Lys Ala Lys Gly His Ala Gln
135 140 145AAG GTT TTA GAG AGT TTG TAGTTTAACT TTCTAACTTT CGCCCATTTT AATTTGAG 544Lys Val Leu Glu Ser Leu
150ATTTTTTAGC CATT 558
(2) Sequence 1210 data:
(i) sequence characteristics:
(A) length: 152 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1210: met Glu Lys Leu Glu Val Gly Gln Leu Ala Pro Asp Phe Arg Leu Lys 151015 Asn Ser Asp Gly Val Glu Ile Ser Leu Lys Asp Leu Leu His Lys Lys
20 25 30Val Val Leu Tyr Phe Tyr Pro Lys Asp Asn Thr Pro Gly Cys Thr Leu
35 40 45Glu Ala Lys Asp Phe Ser Ala Leu Phe Ser Glu Phe Glu Lys Lys Asn
50 55 60Ala Val Val Val Gly Ile Ser Pro Asp Asn Ala Gln Ser His Gln Lys65 70 75 80Phe Ile Ser Gln Cys Ser Leu Asn Val Ile Leu Leu Cys Asp Glu Asp
85 90 95Lys Lys Ala Ala Asn Leu Tyr Lys Ala Tyr Gly Lys Arg Met Leu Tyr
100 105 110Gly Lys Glu His Leu Gly Ile Ile Arg Ser Thr Phe Ile Ile Asn Thr
115 120 125Gln Gly Val Leu Glu Lys Cys Phe Tyr Asn Val Lys Ala Lys Gly His
130 135 140Ala Gln Lys Val Leu Glu Ser Leu145 150
(2) Data of sequence 1211:
(i) sequence characteristics:
(A) length: 700bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...651
(D) Other information:
(xi) Description of the sequence: sequence 1211: ACTTAGAAGG GGTGATTT ATG AGT AAA GAG CTT ATT TTA AAG CGC ATT AAA 51
Met Ser Lys Glu Leu Ile Leu Lys Arg Ile Lys
1 5 10GAA GCC AGA GCC AAG CAT GCC ATT CAG GGA GCG AAC CCT ATT TAT AGG 99Glu Ala Arg Ala Lys His Ala Ile Gln Gly Ala Asn Pro Ile Tyr Arg
15 20 25AAT ATC ATT AAA GTG GAG TTT GAG GAC TTG GTG GAA GAA TAC AAG CAT 147Asn Ile Ile Lys Val Glu Phe Glu Asp Leu Val Glu Glu Tyr Lys His
30 35 40TTC CAA GTG TTG AAT AAA GCT GAA GTC ATT GAA AGC GCT AAA GAA AAT 195Phe Gln Val Leu Asn Lys Ala Glu Val Ile Glu Ser Ala Lys Glu Asn
45 50 55TTA GAG CAA GCC ATT TTA AAG GCT TTA GAA AAT TTT AAA AGC AAA AAA 243Leu Glu Gln Ala Ile Leu Lys Ala Leu Glu Asn Phe Lys Ser Lys Lys60 65 70 75ATC TTA CAC TCC ACA GAT TTG AAT TTG AAT TTT GAA GCG TTT AAG GAT 291Ile Leu His Ser Thr Asp Leu Asn Leu Asn Phe Glu Als Phe Lys Asp
80 85 90TTT ACT TTA CAG CCT TAT GAT AAA GAA ATT GAA GCG ATG CGT GAA GAG 339Phe Thr Leu Gln Pro Tyr Asp Lys Glu Ile Glu Ala Met Arg Glu Glu
95 100 105TTG TTT GAG ATT GAT ACG GCT TTA TTG CAT GGG GTT TGT GGG ATT TCA 387Leu Phe Glu Ile Asp Thr Ala Leu Leu His Gly Val Cys Gly Ile Ser
110 115 120AGC TTG GGC ATG ATT GGG GCG GTC TCT TCG CAT GCA AGC CCG CGA TTG 435Ser Leu Gly Met Ile Gly Ala Val Ser Ser His Ala Ser Pro Arg Leu
125 130 135CTT TCG CTC ATC ACC CTT AAT TGC ATC ATC TTA TTG AAA AAA GAA TCC 483Leu Ser Leu Ile Thr Leu Asn Cys Ile Ile Leu Leu Lys Lys Glu Ser140 145 150 155ATT GTG CGC AAT TTG AGT GAA GGC ATG CAA GCT TTA AAA AAC CAA AGC 531Ile Val Arg Asn Leu Ser Glu Gly Met Gln Ala Leu Lys Asn Gln Ser
160 165 170CAA AAC GGT GCA TTA CCC ACA AAC ATG CTC CTT ATT GGC GGG CCT AGC 579Gln Asn Gly Ala Leu Pro Thr Asn Met Leu Leu Ile Gly Gly Pro Ser
175 180 185CGG ACA GCT GAC ATT GAA TTA AAA ACC GTT TTT GGG GTG CAT GGG CCT 627Arg Thr Ala Asp Ile Glu Leu Lys Thr Val Phe Gly Val His Gly Pro
190 195 200CAA AAA GTC GCT ATC ATT CTC TAC TAAAGGATAA GAATGGAAAA ATTAGAAGTA 681Gln Lys Val Ala Ile Ile Leu Tyr
205 210GGGCAATTAG CCCCTGATT 700
(2) Sequence 1212 data:
(i) sequence characteristics:
(A) length: 211 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description ofthe sequence: sequence 1212: met Ser Lys Glu Leu Ile Leu Lys Arg Ile Lys Glu Ala Arg Ala Lys 151015 His Ala Ile Gln Gly Ala Asn Pro Ile Tyr Arg Asn Ile Ile Lys Val
20 25 30Glu Phe Glu Asp Leu Val Glu Glu Tyr Lys His Phe Gln Val Leu Asn
35 40 45Lys Ala Glu Val Ile Glu Ser Ala Lys Glu Asn Leu Glu Gln Ala Ile
50 55 60Leu Lys Ala Leu Glu Asn Phe Lys Ser Lys Lys Ile Leu His Ser Thr65 70 75 80Asp Leu Asn Leu Asn Phe Glu Ala Phe Lys Asp Phe Thr Leu Gln Pro
85 90 95Tyr Asp Lys Glu Ile Glu Ala Met Arg Glu Glu Leu Phe Glu Ile Asp
100 105 110Thr Ala Leu Leu His Gly Val Cys Gly Ile Ser Ser Leu Gly Met Ile
115 120 125Gly Ala Val Ser Ser His Ala Ser Pro Arg Leu Leu Ser Leu Ile Thr
130 135 140Leu Asn Cys Ile Ile Leu Leu Lys Lys Glu Ser Ile Val Arg Asn Leu145 150 155 160Ser Glu Gly Met Gln Ala Leu Lys Asn Gln Ser Gln Asn Gly Ala Leu
165 170 175Pro Thr Asn Met Leu Leu Ile Gly Gly Pro Ser Arg Thr Ala Asp Ile
180 185 190Glu Leu Lys Thr Val Phe Gly Val His Gly Pro Gln Lys Val Ala Ile
195 200 205Ile Leu Tyr
210
(2) Sequence 1213 data:
(i) sequence characteristics:
(A) length: 571bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 52...531
(D) Other information:
(xi) Description of the sequence: sequence 1213: TATTCCAATA ACGACTACCC TATTATTTTG CCTAGCGGTT CATGCACAGG G ATG ATG 57
Met Met
1CGG CAT GAT TAT TTG GAA TTG TTT GAA GGG CAT GCG GAA TTC AAC ATG 105Arg His Asp Tyr Leu Glu Leu Phe Glu Gly His Ala Glu Phe Asn Met
5 10 15GTT AAA GAT TTT TGC TCT AGG GTG TAT GAA TTG AGC GAA TTT TTG GAT 153Val Lys Asp Phe Cys Ser Arg Val Tyr Glu Leu Ser Glu Phe Leu Asp
20 25 30AAA AAA TTG CAA GTC AAA TAT GAA GAT AAG GGC GAA CCC CTT AAA ATC 201Lys Lys Leu Gln Val Lys Tyr Glu Asp Lys Gly Glu Pro Leu Lys Ile35 40 45 50ACA TGG CAT TCT AAT TGC CAT GCC TTA AGG GTG GCT AAA GTG ATT GAC 249Thr Trp His Ser Asn Cys His Ala Leu Arg Val Ala Lys Val Ile Asp
55 60 65TCG GCG AAA AAC CTC ATC AGA CAG CTT AAA AAT GTG GAA CTC ATT GAA 297Ser Ala Lys Asn Leu Ile Arg Gln Leu Lys Asn Val Glu Leu Ile Glu
70 75 80TTG GAA AAA GAA GAA GAA TGC TGCGGG TTT GGG GGG ACT TTT TCG GTT 345Leu Glu Lys Glu Glu Glu Cys Cys Gly Phe Gly Gly Thr Phe Ser Val
85 90 95AAA GAG CCT GAA ATT TCA GCG GTT ATG GTT AAA GAA AAG ATT AAA AAC 393Lys Glu Pro Glu Ile Ser Ala Val Met Val Lys Glu Lys Ile Lys Asn
100 105 110ATA GAA AGC CGT CAA GTG GAT GTG ATT GTT TCA GCG GAT GCT GGG TGT 441Ile Glu Ser Arg Gln Val Asp Val Ile Val Ser Ala Asp Ala Gly Cys115 120 125 130TTG ATG AAT ATC AGC ACC GCT ATG CAA AAA ATG GGC TCT TTG ACA AAA 489Leu Met Asn Ile Ser Thr Ala Met Gln Lys Met Gly Ser Leu Thr Lys
135 140 145CCC ATG CAT TTT TAT GAC TTT TTA GCC TCA AGA CTT GGG CTT TAACATTAA 540Pro Met His Phe Tyr Asp Phe Leu Ala Ser Arg Leu Gly Leu
150 155 160AGAATTATTT TAAGGAATGA TCATGGAAAA A 571
(2) Sequence 1214 data:
(i) sequence characteristics:
(A) length: 160 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1214: met Met Arg His Asp Tyr Leu Glu Leu Phe Glu Gly His Ala Glu Phe 151015 Asn Met Val Lys Asp Phe Cys Ser Arg Val Tyr Glu Leu Ser Glu Phe
20 25 30Leu Asp Lys Lys Leu Gln Val Lys Tyr Glu Asp Lys Gly Glu Pro Leu
35 4045Lys Ile Thr Trp His Ser Asn Cys His Ala Leu Arg Val Ala Lys Val
50 55 60Ile Asp Ser Ala Lys Asn Leu Ile Arg Gln Leu Lys Asn Val Glu Leu65 70 75 80Ile Glu Leu Glu Lys Glu Glu Glu Cys Cys Gly Phe Gly Gly Thr Phe
85 90 95Ser Val Lys Glu Pro Glu Ile Ser Ala Val Met Val Lys Glu Lys Ile
100 105 110Lys Asn Ile Glu Ser Arg Gln Val Asp Val Ile Val Ser Ala Asp Ala
115 120 125Gly Cys Leu Met Asn Ile Ser Thr Ala Met Gln Lys Met Gly Ser Leu
130 135 140Thr Lys Pro Met His Phe Tyr Asp Phe Leu Ala Ser Arg Leu Gly Leu145 150 155 160
(2) Data of sequence 1215:
(i) sequence characteristics:
(A) length: 759bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 70...714
(D) Other information:
(xi) Description of the sequence: sequence 1215: AACCTGCAAA CCCACCTTAA AAGGCTCAAA AGAAGTGAGT TTGTGGGCCA AAAAAAGGAA 60TTAGAGGGC ATG GGG AGG TTT TCT TTA AAA GAA ATT TTA ATG CTC AGC CTT 111
Met Gly Arg Phe Ser Leu Lys Glu Ile Leu Met Leu Ser Leu
1 5 10ACC TTA TTG GCT TTA CTG GGT TGG ATT TTT GGC AAA CCT TTA GGC TTG 159Thr Leu Leu Ala Leu Leu Gly Trp Ile Phe Gly Lys Pro Leu Gly Leu15 20 25 30CAT GCG AGT GCG ACG GCT TTG ATT GTC ATG GTT TTA ATG GCG TTT TGT 207His Ala Ser Ala Thr Ala Leu Ile Val Met Val Leu Met Ala Phe Cys
35 40 45AAG ATT GTA AGC TAT GAA GAC ATC ATT AAA AAC AAG AGC GCG TTC AAT 255Lys Ile Val Ser Tyr Glu Asp Ile Ile Lys Asn Lys Ser Ala Phe Asn
50 55 60ATT TTT TTA TTG CTT GGA TCG CTG CTC ACG ATG GCT GGC GGG CTT AAA 303Ile Phe Leu Leu Leu Gly Ser Leu Leu Thr Met Ala Gly Gly Leu Lys
65 70 75AAT GTA GGG TTT TTA AAT TTT ATC GGC AAT GCG GCT CAA AAT TTT TTA 351Asn Val Gly Phe Leu Asn Phe Ile Gly Asn Ala Ala Gln Asn Phe Leu
80 85 90GAG CAT GCT CAC TTG GAT CCG TTA ATA GCG GTC TTG TTT ATT GTA GCC 399Glu His Ala His Leu Asp Pro Leu Ile Ala Val Leu Phe Ile Val Ala95 100 105 110CTC TTT TAT CTG TCG CAT TAT TTT TTC GCA AGC ATC ACC GCT CAT GTG 447Leu Phe Tyr Leu Ser His Tyr Phe Phe Ala Ser Ile Thr Ala His Val
115 120 125AGC GCG TTA TTC GCG CTT TTT GTA GGG ATT GGT TCG CAC ATT CAA GGG 495Ser Ala Leu Phe Ala Leu Phe Val Gly Ile Gly Ser His Ile Gln Gly
130 135 140GTC AAT TTG CAA GAA TTG AGC TTG TTT TTA ATG TTT TCT TTA GGG ATT 543Val Asn Leu Gln Glu Leu Ser Leu Phe Leu Met Phe Ser Leu Gly Ile
145 150155ATG GGG ATT TTA ACG CCC TAT GGC ACA GGC CCA TCC ACC ATT TAT TAC 591Met Gly Ile Leu Thr Pro Tyr Gly Thr Gly Pro Ser Thr Ile Tyr Tyr
160 165 170GGG AGC GGG TAT ATT CAA AGC AAG GAT TTT TGG AAA TGG GGG TTT ATT 639Gly Ser Gly Tyr Ile Gln Ser Lys Asp Phe Trp Lys Trp Gly Phe Ile175 180 185 190TTT GGC TTT TTG TAT TTA ATC GTG TTT TTA AGC GTG TGC ACA CCT TGG 687Phe Gly Phe Leu Tyr Leu Ile Val Phe Leu Ser Val Cys Thr Pro Trp
195 200 205GTC AAA TTC ATC GCT TAT AGG TGG TTG TAGCTGGAAA CTTTACACAA CGCCCTT 741Val Lys Phe Ile Ala Tyr Arg Trp Leu
210 215TTAAAATGGT ATGAAGAA 759
(2) Sequence 1216 data:
(i) sequence characteristics:
(A) length: 215 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1216: met Gly Arg Phe Ser Leu Lys Glu Ile Leu Met Leu Ser Leu Thr Leu 151015 Leu Ala Leu Leu Gly Trp Ile Phe Gly Lys Pro Leu Gly Leu His Ala
20 25 30Ser Ala Thr Ala Leu Ile Val Met Val Leu Met Ala Phe Cys Lys Ile
35 40 45Val Ser Tyr Glu Asp Ile Ile Lys Asn Lys Ser Ala Phe Asn Ile Phe
50 55 60Leu Leu Leu Gly Ser Leu Leu Thr Met Ala Gly Gly Leu Lys Asn Val65 70 75 80Gly Phe Leu Asn Phe Ile Gly Asn Ala Ala Gln Asn Phe Leu Glu His
85 90 95Ala His Leu Asp Pro Leu Ile Ala Val Leu Phe Ile Val Ala Leu Phe
100 105 110Tyr Leu Ser His Tyr Phe Phe Ala Ser Ile Thr Ala His Val Ser Ala
115 120 125Leu Phe Ala Leu Phe Val Gly Ile Gly Ser His Ile Gln Gly Val Asn
130 135 140Leu Gln Glu Leu Ser Leu Phe Leu Met Phe Ser Leu Gly Ile Met Gly145 150 155 160Ile Leu Thr Pro Tyr Gly Thr Gly Pro Ser Thr Ile Tyr Tyr Gly Ser
165 170 175Gly Tyr Ile Gln Ser Lys Asp Phe Trp Lys Trp Gly Phe Ile Phe Gly
180 185 190Phe Leu Tyr Leu Ile Val Phe Leu Ser Val Cys Thr Pro Trp Val Lys
195 200 205Phe Ile Ala Tyr Arg Trp Leu
210 215
(2) Sequence 1217 data:
(i) sequence characteristics:
(A) length: 357bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 37...309
(D) Other information:
(xi) Description of the sequence: sequence 1217: AAGGGGGGAT TTATATCGGT AAAGAGTTGT TTAAGC ATG GCT AGT GGC CTT TTT 54
Met Ala Ser Gly Leu Phe
1 5GAA AAC GAT GGA ATC AAA GAC AAC AAA GCG CGA GAT TTT TTC TAT AGC 102Glu Asn Asp Gly Ile Lys Asp Asn Lys Ala Arg Asp Phe Phe Tyr Ser
10 15 20CAT AGC TCC CTA ATT GTC TTT TTC CTT TTA CTG CTT GGG TTT GGG TAT 150His Ser Ser Leu Ile Val Phe Phe Leu Leu Leu Leu Gly Phe Gly Tyr
25 30 35TAT TTA GGG AAG TTG CTT TTT GGG GGC TCT TCT TTA GAA GTT TAT TTG 198Tyr Leu Gly Lys Leu Leu Phe Gly Gly Ser Ser Leu Glu Val Tyr Leu
40 45 50GAT TTA AGA GAC AAG CAT GAA CGA TTG CAG CAA GAA ATC ACC GAA TTG 246Asp Leu Arg Asp Lys His Glu Arg Leu Gln Gln Glu Ile Thr Glu Leu55 60 65 70CAA AGC AAG AAT GTG CGC TTG CAA AAG CGT TTG TTT GAG TTG AAG GAA 294Gln Ser Lys Asn Val Arg Leu Gln Lys Arg Leu Phe Glu Leu Lys Glu
75 80 85TTA CGG CCT AGA GAT TAGATTTAAG GAAAATGGTA GTGTTAAAAA AGATGATAGG T 350Leu Arg Pro Arg Asp
90TTGGTGG 357
(2) Sequence 1218 data:
(i) sequence characteristics:
(A) length: 91 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1218: met Ala Ser Gly Leu Phe Glu Asn Asp Gly Ile Lys Asp Asn Lys Ala 151015 Arg Asp Phe Phe Tyr Ser His Ser Ser Leu Ile Val Phe Phe Leu Leu
20 25 30Leu Leu Gly Phe Gly Tyr Tyr Leu Gly Lys Leu Leu Phe Gly Gly Ser
35 40 45Ser Leu Glu Val Tyr Leu Asp Leu Arg Asp Lys His Glu Arg Leu Gln
50 55 60Gln Glu Ile Thr Glu Leu Gln Ser Lys Asn Val Arg Leu Gln Lys Arg65 70 75 80Leu Phe Glu Leu Lys Glu Leu Arg Pro Arg Asp
85 90
(2) Sequence 1219 data:
(i) sequence characteristics:
(A) length: 678bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 1...675
(D) Other information:
(xi) Description of the sequence: sequence 1219: ATG ATA GAA GTT TTA ATG ATA GAA GAT GAT ATA GAA TTA GCC GAG TTT 48Met Ile Glu Val Leu Met Ile Glu Asp Asp Ile Glu Leu Ala Glu Phe 151015 TTG AGC GAG TTT TTG CTC CAA CAT GGC ATT CAT GTA ACC AAT TAC GAT 96Leu Ser Glu Phe Leu Leu Gln His Gly Ile His Val Thr Asn Tyr Asp
2025 30GAG CCA TAT ACC GGC ATT AGT GCG GCT AAC ACA CAA AAT TAT GAT TTG 144Glu Pro Tyr Thr Gly Ile Ser Ala Ala Asn Thr Gln Asn Tyr Asp Leu
35 40 45TTG TTG TTG GAT TTG ACT TTG CCT AAT TTA GAC GGG CTT GAA GTG TGT 192Leu Leu Leu Asp Leu Thr Leu Pro Asn Leu Asp Gly Leu Glu Val Cys
50 55 60AGG CGC ATC TCC AAA CAA AAA CAT ATC CCT ATT ATT ATT TCT TCA GCG 240Arg Arg Ile Ser Lys Gln Lys His Ile Pro Ile Ile Ile Ser Ser Ala65 70 75 80AGA AGT GAT GTG GAA GAT AAG ATT AAA GCA CTA GAT TAT GGG GCT GAT 288Arg Ser Asp Val Glu Asp Lys Ile Lys Ala Leu Asp Tyr Gly Ala Asp
85 90 95GAT TAC CTC CCT AAA CCC TAT GAT CCT AAA GAA TTA TTA GCT CGC ATC 336Asp Tyr Leu Pro Lys Pro Tyr Asp Pro Lys Glu Leu Leu Ala Arg Ile
100 105 110CAA TCG CTA CTC AGG CGT TCT CAT AAA AAA GAA GAA GTG AGT GAG CCA 384Gln Ser Leu Leu Arg Arg Ser His Lys Lys Glu Glu Val Ser Glu Pro
115 120 125GGC GAT GCG AAT ATC TTT AGG GTG GAT AAG GAT AGC CGA GAA GTG TAT 432Gly Asp Ala Asn Ile Phe Arg Val Asp Lys Asp Ser Arg Glu Val Tyr
130 135 140ATG CAT GAA AAA AAG CTG GAC TTA ACT AGG GCT GAA TAT GAA ATC CTT 480Met His Glu Lys Lys Leu Asp Leu Thr Arg Ala Glu Tyr Glu Ile Leu145 150 155 160TCG CTT CTC ATT AGC AAA AAA GGT TAT GTG TTT AGC CGT GAA AGC ATT 528Ser Leu Leu Ile Ser Lys Lys Gly Tyr Val Phe Ser Arg Glu Ser Ile
165 170 175GCG ATT GAG AGC GAG AGC ATC AAC CCT GAA AGC TCTAAT AAA AGC ATT 576Ala Ile Glu Ser Glu Ser Ile Asn Pro Glu Ser Ser Asn Lys Ser Ile
180 185 190GAT GTG ATC ATT GGC CGT TTG CGA TCT AAG ATT GAA AAA AAT CCT AAA 624Asp Val Ile Ile Gly Arg Leu Arg Ser Lys Ile Glu Lys Asn Pro Lys
195 200 205CAA CCG CAA TAC ATC ATC TCT GTT AGA GGG ATT GGT TAT AAA TTA GAA 672Gln Pro Gln Tyr Ile Ile Ser Val Arg Gly Ile Gly Tyr Lys Leu Glu
210 215 220TAC TGA 678Tyr225
(2) Sequence 1220 data:
(i) sequence characteristics:
(A) length: 225 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1220: met Ile Glu Val Leu Met Ile Glu Asp Asp Ile Glu Leu Ala Glu Phe 151015 Leu Ser Glu Phe Leu Leu Gln His Gly Ile His Val Thr Asn Tyr Asp
20 25 30Glu Pro Tyr Thr Gly Ile Ser Ala Ala Asn Thr Gln Asn Tyr Asp Leu
35 40 45Leu Leu Leu Asp Leu Thr Leu Pro Asn Leu Asp Gly Leu Glu Val Cys
50 55 60Arg Arg Ile Ser Lys Gln Lys His Ile Pro Ile Ile Ile Ser Ser Ala65 70 75 80Arg Ser Asp Val Glu Asp Lys Ile Lys Ala Leu Asp Tyr Gly Ala Asp
85 90 95Asp Tyr Leu Pro Lys Pro Tyr Asp Pro Lys Glu Leu Leu Ala Arg Ile
100 105 110Gln Ser Leu Leu Arg Arg Ser His Lys Lys Glu Glu Val Ser Glu Pro
115 120 125Gly Asp Ala Asn Ile Phe Arg Val Asp Lys Asp Ser Arg Glu Val Tyr
130 135 140Met His Glu Lys Lys Leu Asp Leu Thr Arg Ala Glu Tyr Glu Ile Leu145 150 155 160Ser Leu Leu Ile Ser Lys Lys Gly Tyr Val Phe Ser Arg Glu Ser Ile
165 170 175Ala Ile Glu Ser Glu Ser Ile Asn Pro Glu Ser Ser Asn Lys Ser Ile
180 185 190Asp Val Ile Ile Gly Arg Leu Arg Ser Lys Ile Glu Lys Asn Pro Lys
195 200 205Gln Pro Gln Tyr Ile Ile Ser Val Arg Gly Ile Gly Tyr Lys Leu Glu
210 215 220Tyr225
(2) Sequence 1221 data:
(i) sequence characteristics:
(A) length: 1134bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 72...1082
(D) Other information:
(xi) Description of the sequence: sequence 1221: AAGTCTATGC CACGATCAAT GGTTTCCCTT TCAATTCACA GCTCAAACTT TTAGAAGAAC 60ATATTGATAA A ATG GCA GAA TTA GAG CCG GAC GCT TTT ATT ATC GCT GCG 110
Met Ala Glu Leu Glu Pro Asp Ala Phe Ile Ile Ala Ala
1 5 10CCT GGT GTG GTG AAA CTC GCT TTA AAA ATC GCC CCG CAT ATC CCT ATC 158Pro Gly Val Val Lys Leu Ala Leu Lys Ile Ala Pro His Ile Pro Ile
15 20 25CAT TTA TCC ACG CAA GCG AAT GTC TTA AAT TTG CTA GAT GCA CAA GTG 206His Leu Ser Thr Gln Ala Asn Val Leu Asn Leu Leu Asp Ala Gln Val30 35 40 45TTT TAT GAT TTA GGG GTT AAA CGC ATC GTG TGC GCG AGG GAA TTG AGC 254Phe Tyr Asp Leu Gly Val Lys Arg Ile Val Cys Ala Arg Glu Leu Ser
50 55 60CTG AAT GAT GCG ATT GAG ATT AAA AAA GCC TTA CCT AAT TTA GAA TTA 302Leu Asn Asp Ala Ile Glu Ile Lys Lys Ala Leu Pro Asn Leu Glu Leu
65 70 75GAA ATC TTT GTG CAT GGG AGC ATG TGC TTT GCC TTT TCA GGG CGC TGC 350Glu Ile Phe Val His Gly Ser Met Cys Phe Ala Phe Ser Gly Arg Cys
80 85 90TTG ATT TCG GCC TTA CAA AAG GGG CGC GTG CCT AAT AGA GGG AGT TGC 398Leu Ile Ser Ala Leu Gln Lys Gly Arg Val Pro Asn Arg Gly Ser Cys
95 100 105GCG AAT GAT TGC CGG TTT GAT TAT GAA TAT TAC GTG AAA AAC CCT GAT 446Ala Asn Asp Cys Arg Phe Asp Tyr Glu Tyr Tyr Val Lys Asn Pro Asp110 115 120 125AAT GGC GTG ATG ATG AGA CTG GTT GAA GAA GAG GGC GTA GGC ACG CAT 494Asn Gly Val Met Met Arg Leu Val Glu Glu Glu Gly Val Gly Thr His
130 135 140ATT TTT AAC GCT AAG GAT TTGAAC CTC TCT GGC CAT ATC GCT GAA ATT 542Ile Phe Asn Ala Lys Asp Leu Asn Leu Ser Gly His Ile Ala Glu Ile
145 150 155TTA AGT TCC AAC GCC ATT AGC GCG CTT AAG ATT GAA GGG CGC ACC AAG 590Leu Ser Ser Asn Ala Ile Ser Ala Leu Lys Ile Glu Gly Arg Thr Lys
160 165 170TCC AGT TAC TAC GCC GCG CAA ACC ACG CGC ATC TAT CGT TTA GCG GTT 638Ser Ser Tyr Tyr Ala Ala Gln Thr Thr Arg Ile Tyr Arg Leu Ala Val
175 180 185GAT GAT TTT TAC CAT AAC ACC TTA AAG CCG AGT TTT TAT GCC AGC GAA 686Asp Asp Phe Tyr His Asn Thr Leu Lys Pro Ser Phe Tyr Ala Ser Glu190 195 200 205TTG AAC ACG CTT AAA AAC AGG GGT TTT ACG GAC GGC TAT TTG ATG CGA 734Leu Asn Thr Leu Lys Asn Arg Gly Phe Thr Asp Gly Tyr Leu Met Arg
210 215 220AGG CCT TTT GAA AGG TTG GAT ACT CAA AAC CAC CAA ACA GCC ATT AGC 782Arg Pro Phe Glu Arg Leu Asp Thr Gln Asn His Gln Thr Ala Ile Ser
225 230 235GAA GGG GAT TTT CAA GTC AAT GGC GAA ATA ACC GAA GAC GGG CGT TTT 830Glu Gly Asp Phe Gln Val Asn Gly Glu Ile Thr Glu Asp Gly Arg Phe
240 245 250TTT GCA TGC AAA TTC ACC ACT ACC ACT AAC ACC GCT TAT GAA ATC ATC 878Phe Ala Cys Lys Phe Thr Thr Thr Thr Asn Thr Ala Tyr Glu Ile Ile
255 260 265GCT CCC AAA AAT GCG GCT ATC ACG CCC ATA GTC AAT GAA ATT GGC AAG 926Ala Pro Lys Asn Ala Ala Ile Thr Pro Ile Val Asn Glu Ile Gly Lys270 275 280 285ATT TAC ACC TTT GAA AAA CGC TCT TAT TTA GTG CTG TAT AAA ATC CTT 974Ile Tyr Thr Phe Glu Lys Arg Ser TyrLeu Val Leu Tyr Lys Ile Leu
290 295 300TTA GAA AAT AAC ACC GAG CTA GAA ACT ATC CAT AGC GGG AAC GTG AAT 1022Leu Glu Asn Asn Thr Glu Leu Glu Thr Ile His Ser Gly Asn Val Asn
305 310 315TTA GTG CGA CTG CCC GCA CCC TTA CCG GCT TTT AGT TTT TTA CGC ACC 1070Leu Val Arg Leu Pro Ala Pro Leu Pro Ala Phe Ser Phe Leu Arg Thr
320 325 330CAA GTC AGA GTC TAAAAATGGC GTTTAGAGAT TAGGTATTGA AAATGATTAA GAGAA 1127Gln Val Arg Val
335ACGCATG 1134
(2) Sequence 1222 data:
(i) sequence characteristics:
(A) length: 337 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1222: met Ala Glu Leu Glu Pro Asp Ala Phe Ile Ile Ala Ala Pro Gly Val 151015 Val Lys Leu Ala Leu Lys Ile Ala Pro His Ile Pro Ile His Leu Ser
20 25 30Thr Gln Ala Asn Val Leu Asn Leu Leu Asp Ala Gln Val Phe Tyr Asp
35 40 45Leu Gly Val Lys Arg Ile Val Cys Ala Arg Glu Leu Ser Leu Asn Asp
50 55 60Ala Ile Glu Ile Lys Lys Ala Leu Pro Asn Leu Glu Leu Glu Ile Phe65 70 75 80Val His Gly Ser Met Cys Phe Ala Phe Ser Gly Arg Cys Leu Ile Ser
85 90 95Ala Leu Gln Lys Gly Arg Val Pro Asn Arg Gly Ser Cys Ala Asn Asp
100 105 110Cys Arg Phe Asp Tyr Glu Tyr Tyr Val Lys Asn Pro Asp Asn Gly Val
115 120 125Met Met Arg Leu Val Glu Glu Glu Gly Val Gly Thr His Ile Phe Asn
130 135 140Ala Lys Asp Leu Asn Leu Ser Gly His Ile Ala Glu Ile Leu Ser Ser145 150 155 160Asn Ala Ile Ser Ala Leu Lys Ile Glu Gly Arg Thr Lys Ser Ser Tyr
165 170 175Tyr Ala Ala Gln Thr Thr Arg Ile Tyr Arg Leu Ala Val Asp Asp Phe
180 185 190Tyr His Asn Thr Leu Lys Pro Ser Phe Tyr Ala Ser Glu Leu Asn Thr
195 200 205Leu Lys Asn Arg Gly Phe Thr Asp Gly Tyr Leu Met Arg Arg Pro Phe
210 215 220Glu Arg Leu Asp Thr Gln Asn His Gln Thr Ala Ile Ser Glu Gly Asp225 230 235 240Phe Gln Val Asn Gly Glu Ile Thr Glu Asp Gly Arg Phe Phe Ala Cys
245 250 255Lys Phe Thr Thr Thr Thr Asn Thr Ala Tyr Glu Ile Ile Ala Pro Lys
260 265 270Asn Ala Ala Ile Thr Pro Ile Val Asn Glu Ile Gly Lys Ile Tyr Thr
275 280 285Phe Glu Lys Arg Ser Tyr Leu Val Leu Tyr Lys Ile Leu Leu Glu Asn
290 295 300Asn Thr Glu Leu Glu Thr Ile His Ser Gly Asn Val Asn Leu Val Arg305310 315 320Leu Pro Ala Pro Leu Pro Ala Phe Ser Phe Leu Arg Thr Gln Val Arg
325 330 335Val
(2) Sequence 1223 data:
(i) sequence characteristics:
(A) length: 1123bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...1038
(D) Other information:
(xi) Description of the sequence: sequence 1223: ATTAAGGAGA AATAAGAA ATG TTA CAA CCC CCT AAA ATT GTC GCT GAA TTG 51
Met Leu Gln Pro Pro Lys Ile Val Ala Glu Leu
1 5 10AGC GCT AAT CAT AAC CAG GAT TTA AAC CTA GCC AAA GAA AGC CTT CAT 99Ser Ala Asn His Asn Gln Asp Leu Asn Leu Ala Lys Glu Ser Leu His
15 20 25GCC ATT AAG GAA AGC GGT GCG GAT TTT GTC AAG CTC CAA ACC TAC ACG 147Ala Ile Lys Glu Ser Gly Ala Asp Phe Val Lys Leu Gln Thr Tyr Thr
30 35 40CCA AGC TGC ATG ACT TTA AAC TCT AAA GAA GAT CCT TTC ATC ATT CAA 195Pro Ser Cys Met Thr Leu Asn Ser Lys Glu Asp Pro Phe Ile Ile Gln
45 50 55GGC ACT TTA TGG GAT AAA GAA AAT TTG TAT GAA TTG TAT CAA AAG GCT 243Gly Thr Leu Trp Asp Lys GluAsn Leu Tyr Glu Leu Tyr Gln Lys Ala60 65 70 75TCT ACC CCC CTA GAA TGG CAT GCT GAA TTG TTT GAG TTG GCT AGA AAG 291Ser Thr Pro Leu Glu Trp His Ala Glu Leu Phe Glu Leu Ala Arg Lys
80 85 90CTT GAT TTA GGC ATT TTT AGC TCG CCT TTT AGT TCA CAA GCT TTA GAG 339Leu Asp Leu Gly Ile Phe Ser Ser Pro Phe Ser Ser Gln Ala Leu Glu
95 100 105CTT TTA GAG AGC CTA AAT TGC CCC ATG TAT AAA ATC GCT AGT TTT GAA 387Leu Leu Glu Ser Leu Asn Cys Pro Met Tyr Lys Ile Ala Ser Phe Glu
110 115 120ATC GTT GAT TTG GAC TTG ATT GAA AAG GCC GCT CGC ACA CAA AAG CCC 435Ile Val Asp Leu Asp Leu Ile Glu Lys Ala Ala Arg Thr Gln Lys Pro
125 130 135ATT ATC CTT TCT AGC GGT ATC GCT ACA CAC ACC GAA TTG CAA GAC GCT 483Ile Ile Leu Ser Ser Gly Ile Ala Thr His Thr Glu Leu Gln Asp Ala140 145 150 155ATC TCA TTG TGC AGA AGA GTG AAT AAT TTT GAC ATC ACC CTT TTA AAA 531Ile Ser Leu Cys Arg Arg Val Asn Asn Phe Asp Ile Thr Leu Leu Lys
160 165 170TGC GTG AGC GCT TAT CCC AGT AAA ATA GAA GAC GCT AAC TTG TTG AGC 579Cys Val Ser Ala Tyr Pro Ser Lys Ile Glu Asp Ala Asn Leu Leu Ser
175 180 185ATG GTT AAA TTA GGC GAA ATC TTT GGC GTT AAA TTT GGC TTG AGC GAT 627Met Val Lys Leu Gly Glu Ile Phe Gly Val Lys Phe Gly Leu Ser Asp
190 195 200CAC ACG ATT GGC TCT CTT TGC CCC ATT TTA GCC ACC ACT TTA GGA GCG 675His Thr Ile Gly Ser Leu Cys Pro Ile Leu Ala Thr Thr Leu Gly Ala
205210 215AGC ATG ATA GAA AAG CAT TTC ATT TTA AAC AAA TCC TTA CAA ACC CCA 723Ser Met Ile Glu Lys His Phe Ile Leu Asn Lys Ser Leu Gln Thr Pro220 225 230 235GAC AGC GCT TTT AGC ATG GAT TTT AAC GGA TTT AAA AGC ATG GTT GAA 771Asp Ser Ala Phe Ser Met Asp Phe Asn Gly Phe Lys Ser Met Val Glu
240 245 250GCC ATC AAG CAA AGC GTT TTA GCC TTA GGC GAA GAA GAG CCA AGA ATC 819Ala Ile Lys Gln Ser Val Leu Ala Leu Gly Glu Glu Glu Pro Arg Ile
255 260 265AAT CCA AAG ACT TTA GAA AAG CGA AGA TTT TTT GCA CGC TCT TTA TTT 867Asn Pro Lys Thr Leu Glu Lys Arg Arg Phe Phe Ala Arg Ser Leu Phe
270 275 280GTT ATT AAG GAT ATT CAA AAA GGC GAA GCA TTG ACT GAA AAC AAT ATC 915Val Ile Lys Asp Ile Gln Lys Gly Glu Ala Leu Thr Glu Asn Asn Ile
285 290 295AAA GCC TTA CGC CCC AAC CTT GGC TTA CAC CCT AAA TTT TAT AAA GAA 963Lys Ala Leu Arg Pro Asn Leu Gly Leu His Pro Lys Phe Tyr Lys Glu300 305 310 315ATT TTA GGC CAA AAA GCA TCA AAA TTC TTA AAA GCC AAC ACC CCC TTA 1011Ile Leu Gly Gln Lys Ala Ser Lys Phe Leu Lys Ala Asn Thr Pro Leu
320 325 330AGC GCT GAT GAT ATA GAA CGC TCA TTG TAGGTTCGTT TTGATCAAAA AATGGGG 1065Ser Ala Asp Asp Ile Glu Arg Ser Leu
335 340TTTTTAATTT TGTTTTATGG TTTTAGATTT GATTTTAAAC TCATTTTCTT TATTTTAA 1123
(2) Sequence 1224 data:
(i) sequence characteristics:
(A) length: 340 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1224: met Leu Gln Pro Pro Lys Ile Val Ala Glu Leu Ser Ala Asn His Asn 151015 Gln Asp Leu Asn Leu Ala Lys Glu Ser Leu His Ala Ile Lys Glu Ser
20 25 30Gly Ala Asp Phe Val Lys Leu Gln Thr Tyr Thr Pro Ser Cys Met Thr
35 40 45Leu Asn Ser Lys Glu Asp Pro Phe Ile Ile Gln Gly Thr Leu Trp Asp
50 55 60Lys Glu Asn Leu Tyr Glu Leu Tyr Gln Lys Ala Ser Thr Pro Leu Glu65 70 75 80Trp His Ala Glu Leu Phe Glu Leu Ala Arg Lys Leu Asp Leu Gly Ile
85 90 95Phe Ser Ser Pro Phe Ser Ser Gln Ala Leu Glu Leu Leu Glu Ser Leu
100 105 110Asn Cys Pro Met Tyr Lys Ile Ala Ser Phe Glu Ile Val Asp Leu Asp
115 120 125Leu Ile Glu Lys Ala Ala Arg Thr Gln Lys Pro Ile Ile Leu Ser Ser
130 135 140Gly Ile Ala Thr His Thr Glu Leu Gln Asp Ala Ile Ser Leu Cys Arg145 150 155 160Arg Val Asn Asn Phe Asp Ile Thr Leu Leu Lys Cys Val Ser Ala Tyr
165 170 175Pro Ser Lys Ile Glu Asp Ala Asn Leu Leu Ser Met Val Lys Leu Gly
180 185 190Glu Ile Phe Gly Val Lys Phe GlyLeu Ser Asp His Thr Ile Gly Ser
195 200 205Leu Cys Pro Ile Leu Ala Thr Thr Leu Gly Ala Ser Met Ile Glu Lys
210 215 220His Phe Ile Leu Asn Lys Ser Leu Gln Thr Pro Asp Ser Ala Phe Ser225 230 235 240Met Asp Phe Asn Gly Phe Lys Ser Met Val Glu Ala Ile Lys Gln Ser
245 250 255Val Leu Ala Leu Gly Glu Glu Glu Pro Arg Ile Asn Pro Lys Thr Leu
260 265 270Glu Lys Arg Arg Phe Phe Ala Arg Ser Leu Phe Val Ile Lys Asp Ile
275 280 285Gln Lys Gly Glu Ala Leu Thr Glu Asn Asn Ile Lys Ala Leu Arg Pro
290 295 300Asn Leu Gly Leu His Pro Lys Phe Tyr Lys Glu Ile Leu Gly Gln Lys305 310 315 320Ala Ser Lys Phe Leu Lys Ala Asn Thr Pro Leu Ser Ala Asp Asp Ile
325 330 335Glu Arg Ser Leu
340
(2) Sequence 1225 data:
(i) sequence characteristics:
(A) length: 1234bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...1197
(D) Other information:
(xi) Description of the sequence: sequence 1225: GTGAATGAGC GTTTGGAGGT GCTGTTGGAA ATG GTT TTG ATG CGG TTT GAA GAG 54
Met Val Leu Met Arg Phe Glu Glu
1 5CCC GAT CCT GGA AGA GCT ATC AGA ACC TTT CAG AGC GTG AAT GAC AGA 102Pro Asp Pro Gly Arg Ala Ile Arg Thr Phe Gln Ser Val Asn Asp Arg
10 15 20GGC GTG CCT CTC CTC TTG CTA GAC AAA CTA AAA TCC CTT CTC ATC TAT 150Gly Val Pro Leu Leu Leu Leu Asp Lys Leu Lys Ser Leu Leu Ile Tyr25 30 35 40TAC TCC AAC ATT TTT TGC GAT GGG AAA AGG GGG CTA GAC CAA TTT ATC 198Tyr Ser Asn Ile Phe Cys Asp Gly Lys Arg Gly Leu Asp Gln Phe Ile
45 50 55ATC GAT CAT TTT GGG GAG ATC TTT AAG ATC TTT GCC AAG ATT AAA AAG 246Ile Asp His Phe Gly Glu Ile Phe Lys Ile Phe Ala Lys Ile Lys Lys
60 65 70AGC GAC CAC ATC TCC AGC GTT GGA GGC TTT GAT GAA GGC GAT ATC TTC 294Ser Asp His Ile Ser Ser Val Gly Gly Phe Asp Glu Gly Asp Ile Phe
75 80 85CGC TAC CAC GCA GGG AGC CAA AAA TTT GAT GGA ATC GAG TTT TTA GGG 342Arg Tyr His Ala Gly Ser Gln Lys Phe Asp Gly Ile Glu Phe Leu Gly
90 95 100CAC TAC GAA GCA AGC ACG GAC AAA ACC TAC GAG AAA CTC AAA GAT GAA 390His Tyr Glu Ala Ser Thr Asp Lys Thr Tyr Glu Lys Leu Lys Asp Glu105 110 115 120CTA AAA AAA ATC AAA AAA AGC AAA TTG AAA AGT TTC ATC CAA TCC TAT 438Leu Lys Lys Ile Lys Lys Ser Lys Leu Lys Ser Phe Ile Gln Ser Tyr
125130 135GTC AGC GAT TTG AAA AAT TTC TAT CAG GCT TTT CTT GAT CTA TTG AGC 486Val Ser Asp Leu Lys Asn Phe Tyr Gln Ala Phe Leu Asp Leu Leu Ser
140 145 150GAG ATT GAC ACC AAC CCA ACC ACC TTT AAG GTC ATG CTC ATC AAC AAG 534Glu Ile Asp Thr Asn Pro Thr Thr Phe Lys Val Met Leu Ile Asn Lys
155 160 165ATC GAC TCG TCT TTT TTC AAT TCG CTC ATC CGC CTG AAA ATC AAC AAC 582Ile Asp Ser Ser Phe Phe Asn Ser Leu Ile Arg Leu Lys Ile Asn Asn
170 175 180GAA CTA GAC GAT GAA ACG CTG AAA CTC TTT GCC AAA ACC GAT ATT GTG 630Glu Leu Asp Asp Glu Thr Leu Lys Leu Phe Ala Lys Thr Asp Ile Val185 190 195 200CTT TTC AAA GCT ACT AGA GAT AGG CCA GGA ACG GAC AAC CTG ATT AAT 678Leu Phe Lys Ala Thr Arg Asp Arg Pro Gly Thr Asp Asn Leu Ile Asn
205 210 215GCG TAT CTT AAA AAG GGC AAA GAG GGA TTG AAG AGC GAG ATG ATT GCT 726Ala Tyr Leu Lys Lys Gly Lys Glu Gly Leu Lys Ser Glu Met Ile Ala
220 225 230CAA TGC AGA AAT GAT ATA GGG CTG GCT TTT TGG CAG TCT GTA AAC AAC 774Gln Cys Arg Asn Asp Ile Gly Leu Ala Phe Trp Gln Ser Val Asn Asn
235 240 245GCA TCC AAC TCA TCA TGC TTC CAC TAT ATC TTC TTT GAA AAG AAC TGC 822Ala Ser Asn Ser Ser Cys Phe His Tyr Ile Phe Phe Glu Lys Asn Cys
250 255 260CAG GAG ATG GGT CTT GCC GAT CTC AAA AAA TTG ATC CCT AGG AAG CAA 870Gln Glu Met Gly Leu Ala Asp Leu Lys Lys Leu Ile Pro Arg Lys Gln265 270 275 280TTC TCC CAA GAA AAA GAA CAC ATC ATC CCC ATC AAT TTATTA AAA CAG 918Phe Ser Gln Glu Lys Glu His Ile Ile Pro Ile Asn Leu Leu Lys Gln
285 290 295GAA TCC AAC AAT AAG ATC AGA GAT CTT GGT TTT GAA GAC AAA AAA GAT 966Glu Ser Asn Asn Lys Ile Arg Asp Leu Gly Phe Glu Asp Lys Lys Asp
300 305 310CTT GAA GAC TAC ATT GAC ACA TAC GGC AAC CTC ATC TCC CTG GAA AAA 1014Leu Glu Asp Tyr Ile Asp Thr Tyr Gly Asn Leu Ile Ser Leu Glu Lys
315 320 325TCG CTC AAT CGT AAG GCA AGC GAT AAG GAT CTG TAT GGA AAA GAT GAA 1062Ser Leu Asn Arg Lys Ala Ser Asp Lys Asp Leu Tyr Gly Lys Asp Glu
330 335 340ATC TAT AAA AGT AGT GAG ATC CCT TTC AAC AGG CGC TTT GAT ACA AAA 1110Ile Tyr Lys Ser Ser Glu Ile Pro Phe Asn Arg Arg Phe Asp Thr Lys345 350 355 360AAC TTC AAT AAG AAG GCA TTG GTA AAA AGA AAT GAA GAA ATG CGA GAA 1158Asn Phe Asn Lys Lys Ala Leu Val Lys Arg Asn Glu Glu Met Arg Glu
365 370 375TGG CTG ATC GAC ACC TTT TTT AAG GAT TTC GCC GCC CAC TAAAGAGAGT GA 1209Trp Leu Ile Asp Thr Phe Phe Lys Asp Phe Ala Ala His
380 385GATTAAAAGA GAGTGATCGC ACTCA 1234
(2) Sequence 1226 data:
(i) sequence characteristics:
(A) length: 389 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1226: met Val Leu Met Arg Phe Glu Glu Pro Asp Pro Gly Arg Ala Ile Arg 151015 Thr Phe Gln Ser Val Asn Asp Arg Gly Val Pro Leu Leu Leu Leu Asp
20 25 30Lys Leu Lys Ser Leu Leu Ile Tyr Tyr Ser Asn Ile Phe Cys Asp Gly
35 40 45Lys Arg Gly Leu Asp Gln Phe Ile Ile Asp His Phe Gly Glu Ile Phe
50 55 60Lys Ile Phe Ala Lys Ile Lys Lys Ser Asp His Ile Ser Ser Val Gly65 70 75 80Gly Phe Asp Glu Gly Asp Ile Phe Arg Tyr His Ala Gly Ser Gln Lys
85 90 95Phe Asp Gly Ile Glu Phe Leu Gly His Tyr Glu Ala Ser Thr Asp Lys
100 105 110Thr Tyr Glu Lys Leu Lys Asp Glu Leu Lys Lys Ile Lys Lys Ser Lys
115 120 125Leu Lys Ser Phe Ile Gln Ser Tyr Val Ser Asp Leu Lys Asn Phe Tyr
130 135 140Gln Ala Phe Leu Asp Leu Leu Ser Glu Ile Asp Thr Asn Pro Thr Thr145 150 155 160Phe Lys Val Met Leu Ile Asn Lys Ile Asp Ser Ser Phe Phe Asn Ser
165 170 175Leu Ile Arg Leu Lys Ile Asn Asn Glu Leu Asp Asp Glu Thr Leu Lys
180 185 190Leu Phe Ala Lys Thr Asp Ile Val Leu Phe Lys Ala Thr Arg Asp Arg
195 200 205Pro Gly Thr Asp Asn Leu Ile Asn Ala Tyr Leu Lys Lys Gly Lys Glu
210 215 220Gly Leu Lys Ser Glu Met Ile Ala Gln Cys Arg Asn Asp Ile Gly Leu225 230 235 240Ala Phe Trp Gln Ser Val Asn Asn Ala Ser Asn Ser Ser Cys Phe His
245 250 255Tyr Ile Phe Phe Glu Lys Asn Cys Gln Glu Met Gly Leu Ala Asp Leu
260 265 270Lys Lys Leu Ile Pro Arg Lys Gln Phe Ser Gln Glu Lys Glu His Ile
275 280 285Ile Pro Ile Asn Leu Leu Lys Gln Glu Ser Asn Asn Lys Ile Arg Asp
290 295 300Leu Gly Phe Glu Asp Lys Lys Asp Leu Glu Asp Tyr Ile Asp Thr Tyr305 310 315 320Gly Asn Leu Ile Ser Leu Glu Lys Ser Leu Asn Arg Lys Ala Ser Asp
325 330 335Lys Asp Leu Tyr Gly Lys Asp Glu Ile Tyr Lys Ser Ser Glu Ile Pro
340 345 350Phe Asn Arg Arg Phe Asp Thr Lys Asn Phe Asn Lys Lys Ala Leu Val
355 360 365Lys Arg Asn Glu Glu Met Arg Glu Trp Leu Ile Asp Thr Phe Phe Lys
370 375 380Asp Phe Ala Ala His385
(2) Sequence 1227 data:
(i) sequence characteristics:
(A) length: 889bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A)name/keyword: coding sequence
(B) Position: 16...840
(D) Other information:
(xi) Description of the sequence: sequence 1227: TTATAAAGGA AAATC ATG GGA TTT TTA AAA GGT AAA AAA GGG CTT ATT GTA 51
Met Gly Phe Leu Lys Gly Lys Lys Gly Leu Ile Val
1 5 10GGG GTG GCG AAC AAT AAA TCC ATC GCT TAT GGG ATC GCT CAA TCT TGT 99Gly Val Ala Asn Asn Lys Ser Ile Ala Tyr Gly Ile Ala Gln Ser Cys
15 20 25TTC AAT CAA GGG GCT ACT TTG GCT TTC ACT TAT TTG AAT GAG AGT TTA 147Phe Asn Gln Gly Ala Thr Leu Ala Phe Thr Tyr Leu Asn Glu Ser Leu
30 35 40GAA AAG CGC GTA AGG CCT ATC GCG CAG GAA TTG AAT AGC CCC TAT GTG 195Glu Lys Arg Val Arg Pro Ile Ala Gln Glu Leu Asn Ser Pro Tyr Val45 50 55 60TAT GAA TTG GAT GTG AGC AAA GAA GAG CAT TTC AAG TCG CTA TAC AAT 243Tyr Glu Leu Asp Val Ser Lys Glu Glu His Phe Lys Ser Leu Tyr Asn
65 70 75AGC GTT AAA AAG GAT TTA GGC TCA TTG GAT TTT ATT GTT CAT AGC GTG 291Ser Val Lys Lys Asp Leu Gly Ser Leu Asp Phe Ile Val His Ser Val
80 85 90GCC TTT GCC CCT AAA GAG GCT TTA GAG GGG AGC TTG TTG GAA ACT TCT 339Ala Phe Ala Pro Lys Glu Ala Leu Glu Gly Ser Leu Leu Glu Thr Ser
95 100 105AAA AGC GCG TTT AAC ACC GCT ATG GAA ATT TCT GTT TAT TCT TTA ATA 387Lys Ser Ala Phe Asn Thr Ala Met Glu Ile Ser Val Tyr Ser Leu Ile
110 115 120GAG CTG ACA AAC ACC CTA AAA CCT TTA TTG AAT AACGGA GCG TCT GTT 435Glu Leu Thr Asn Thr Leu Lys Pro Leu Leu Asn Asn Gly Ala Ser Val125 130 135 140TTG ACT CTA AGC TAT TTG GGT AGC ACC AAA TAC ATG GCG CAT TAC AAT 483Leu Thr Leu Ser Tyr Leu Gly Ser Thr Lys Tyr Met Ala His Tyr Asn
145 150 155GTG ATG GGG TTG GCT AAA GCG GCC CTA GAG AGT GCG GTG CGT TAT TTA 531Val Met Gly Leu Ala Lys Ala Ala Leu Glu Ser Ala Val Arg Tyr Leu
160 165 170GCG GTG GAT TTA GGC AAA CAC CAT ATA AGA GTG AAT GCC CTA TCG GCC 579Ala Val Asp Leu Gly Lys His His Ile Arg Val Asn Ala Leu Ser Ala
175 180 185GGG CCT ATT AGG ACG CTC GCT TCT AGC GGG ATC GCT GAT TTT AGA ATG 627Gly Pro Ile Arg Thr Leu Ala Ser Ser Gly Ile Ala Asp Phe Arg Met
190 195 200ATT TTA AAA TGG AAT GAA ATC AAC GCC CCT TTA AGA AAA AAT GTG AGT 675Ile Leu Lys Trp Asn Glu Ile Asn Ala Pro Leu Arg Lys Asn Val Ser205 210 215 220TTA GAA GAA GTG GGC AAT GCC GGG ATG TAT TTG CTC TCT AGT TTG TCT 723Leu Glu Glu Val Gly Asn Ala Gly Met Tyr Leu Leu Ser Ser Leu Ser
225 230 235AGC GGG GTG AGT GGG GAA GTG CAT TTT GTG GAT GCT GGC TAT CAT GTT 771Ser Gly Val Ser Gly Glu Val His Phe Val Asp Ala Gly Tyr His Val
240 245 250ATG GGC ATG GGG GCT GTG GAA GAA AAA GAT AAT AAA GCT ACG CTA CTG 819Met Gly Met Gly Ala Val Glu Glu Lys Asp Asn Lys Ala Thr Leu Leu
255 260 265TGG GAT TTG CAT AAA GAA CAA TAAGGGGTAT TGATGAAATT AAGCGAATTG TTAA 874Trp Asp Leu His Lys Glu Gln
270 275ACGCCTATTC TATTG 889
(2) Sequence 1228 data:
(i) sequence characteristics:
(A) length: 275 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1228: met Gly Phe Leu Lys Gly Lys Lys Gly Leu Ile Val Gly Val Ala Asn 151015 Asn Lys Ser Ile Ala Tyr Gly Ile Ala Gln Ser Cys Phe Asn Gln Gly
20 25 30Ala Thr Leu Ala Phe Thr Tyr Leu Asn Glu Ser Leu Glu Lys Arg Val
35 40 45Arg Pro Ile Ala Gln Glu Leu Asn Ser Pro Tyr Val Tyr Glu Leu Asp
50 55 60Val Ser Lys Glu Glu His Phe Lys Ser Leu Tyr Asn Ser Val Lys Lys65 70 75 80Asp Leu Gly Ser Leu Asp Phe Ile Val His Ser Val Ala Phe Ala Pro
85 90 95Lys Glu Ala Leu Glu Gly Ser Leu Leu Glu Thr Ser Lys Ser Ala Phe
100 105 110Asn Thr Ala Met Glu Ile Ser Val Tyr Ser Leu Ile Glu Leu Thr Asn
115 120 125Thr Leu Lys Pro Leu Leu Asn Asn Gly Ala Ser Val Leu Thr Leu Ser
130 135 140Tyr Leu Gly Ser Thr Lys Tyr Met Ala His Tyr Asn Val Met Gly Leu145 150 155 160Ala Lys Ala Ala Leu Glu Ser Ala Val Arg Tyr Leu Ala Val Asp Leu
165 170 175Gly Lys His His Ile Arg Val Asn Ala Leu Ser Ala Gly Pro Ile Arg
180 185 190Thr Leu Ala Ser Ser Gly Ile Ala Asp Phe Arg Met Ile Leu Lys Trp
195 200 205Asn Glu Ile Asn Ala Pro Leu Arg Lys Asn Val Ser Leu Glu Glu Val
210 215 220Gly Asn Ala Gly Met Tyr Leu Leu Ser Ser Leu Ser Ser Gly Val Ser225 230 235 240Gly Glu Val His Phe Val Asp Ala Gly Tyr His Val Met Gly Met Gly
245 250 255Ala Val Glu Glu Lys Asp Asn Lys Ala Thr Leu Leu Trp Asp Leu His
260 265 270Lys Glu Gln275
(2) Sequence 1229 data:
(i) sequence characteristics:
(A) length: 1760bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 33...1688
(D) Other information:
(xi) Description of the sequence: sequence 1229: TGGAGGTTAG TAATTTTAAA GGGTAAAATA AA ATG GAA AAT CAT TCG CAT GCC 53
Met Glu Asn His Ser His Ala
1 5AAT ACG CAT ACC GAT ACG CGC ACC GAT GAT AAA AGC ACT AAG ATC GTG 101Asn Thr His Thr Asp Thr Arg Thr Asp Asp Lys Ser Thr Lys Ile Val
10 15 20CGC TTG TTG GGG TTA ATA GGG GGA GCG TTA ATC GCG CTT GTT ATC TAC 149Arg Leu Leu Gly Leu Ile Gly Gly Ala Leu Ile Ala Leu Val Ile Tyr
25 30 35TAT GCG CTC AAT TCT CAA ATG CCT CAT ATT GTA GAA GAA ATC CCC AAG 197Tyr Ala Leu Asn Ser Gln Met Pro His Ile Val Glu Glu Ile Pro Lys40 45 50 55CTC AGT TCT TTG AAT TAT AAG GCG ATG CCT GTT GTG GCA GGG GTG GCT 245Leu Ser Ser Leu Asn Tyr Lys Ala Met Pro Val Val Ala Gly Val Ala
60 65 70GTT TTA ATG GGG ATA TGG TGG ATG ACT GAA GCC ATT GAC TTG CCC GCA 293Val Leu Met Gly Ile Trp Trp Met Thr Glu Ala Ile Asp Leu Pro Ala
75 80 85ACC GCG CTT TTA CCT TTG GTG CTT TTT AGC GTC TTT AGC GTG GAT CAA 341Thr Ala Leu Leu Pro Leu Val Leu Phe Ser Val Phe Ser Val Asp Gln
90 95 100TTC GCT AGC GTC AGC TCT TCT TAC GCA TCG CCG ATC ATC TTT CTT TTT 389Phe Ala Ser Val Ser Ser Ser Tyr Ala Ser Pro Ile Ile Phe Leu Phe
105 110 115ATG GGA GGG TTT ATT TTA GCC CTA AGC ATG CAA AAA TGG AAT TTG CAC 437Met Gly Gly Phe Ile Leu Ala Leu Ser Met Gln Lys Trp Asn Leu His120 125 130 135ACG CGC ATC GCT TTA AGC ATT ATT TTA TTA GTA GGC ACA AGC CCT AGG 485Thr Arg Ile Ala Leu Ser Ile Ile Leu Leu Val Gly Thr Ser Pro Arg
140 145 150AGG TTG ATTTTA GGT TTC ATG ATG GCT ACA GGC TTT CTG TCT ATG TGG 533Arg Leu Ile Leu Gly Phe Met Met Ala Thr Gly Phe Leu Ser Met Trp
155 160 165GTG AGC AAT ACC GCA ACG GCG GTG ATG ATG CTC CCT GTT GGC ATG AGC 581Val Ser Asn Thr Ala Thr Ala Val Met Met Leu Pro Val Gly Met Ser
170 175 180GTT TTG CAA TTA GTC GCT AAA CTG GTG GGC AAA GAA GAC GCC TCT AAT 629Val Leu Gln Leu Val Ala Lys Leu Val Gly Lys Glu Asp Ala Ser Asn
185 190 195TCA TGG CAT CAA AAA GAA GAA ATC ACC AAA GCG CAT GGG GGT ATT ATG 677Ser Trp His Gln Lys Glu Glu Ile Thr Lys Ala His Gly Gly Ile Met200 205 210 215AGT AAT ATC GTG CAT AAG GGT AAA GAT ATT ACT CAA GTC ATT CAA GAA 725Ser Asn Ile Val His Lys Gly Lys Asp Ile Thr Gln Val Ile Gln Glu
220 225 230AAG ACT ACT ATC TAT CGC ACG AAT TTC AGT ATT TGC TTG ATG CTT GGC 773Lys Thr Thr Ile Tyr Arg Thr Asn Phe Ser Ile Cys Leu Met Leu Gly
235 240 245ATC GCT TAT GCG GCT TCT ATT GGC TCT TTA GGC ACT TTG ATT GGC ACG 821Ile Ala Tyr Ala Ala Ser Ile Gly Ser Leu Gly Thr Leu Ile Gly Thr
250 255 260CCG CCT AAC GCT TTA TTG GCC GGC TAT ATG AAA ACC GCT TTC AAT ATT 869Pro Pro Asn Ala Leu Leu Ala Gly Tyr Met Lys Thr Ala Phe Asn Ile
265 270 275GAA ATT GAT TTC GCT CAG TGG ATG GTG TTT GGG ACG CCG TTA GCC TTT 917Glu Ile Asp Phe Ala Gln Trp Met Val Phe Gly Thr Pro Leu Ala Phe280 285 290 295ATC ATG CTC ATT TTA GCG TGG CTC TTG CTC ACT TAT GTG ATT TTC CCT 965Ile Met Leu Ile Leu Ala TrpLeu Leu Leu Thr Tyr Val Ile Phe Pro
300 305 310TTA AAG ATT AAA GAA ATC CCA GGG GGT AAG GAA GTC ATT AGG GTA GAG 1013Leu Lys Ile Lys Glu Ile Pro Gly Gly Lys Glu Val Ile Arg Val Glu
315 320 325TTA AAA AAA TTA GGC CGT TTG AGT CAG GCG GAA ATC TCT GTG GGG ATT 1061Leu Lys Lys Leu Gly Arg Leu Ser Gln Ala Glu Ile Ser Val Gly Ile
330 335 340ATT TTT ATT TTA GCG TCT TTA GGG TGG ATT TTT TTA GGC GTA ATG TTA 1109Ile Phe Ile Leu Ala Ser Leu Gly Trp Ile Phe Leu Gly Val Met Leu
345 350 355AAA TCT TGG GGC GTT AAG ATA GAT AAA ATT GAT TCA GTG ATC GCT ATG 1157Lys Ser Trp Gly Val Lys Ile Asp Lys Ile Asp Ser Val Ile Ala Met360 365 370 375GGG GTT TCT GCG CTT TTA TTC ATT TTG CCC GCT AAC CAT CAG GGC GAT 1205Gly Val Ser Ala Leu Leu Phe Ile Leu Pro Ala Asn His Gln Gly Asp
380 385 390AGG CTC ATT GAT TGG GGT GTT GCT AAA AAA CTC CCT TGG GAT GTG TTG 1253Arg Leu Ile Asp Trp Gly Val Ala Lys Lys Leu Pro Trp Asp Val Leu
395 400 405CTT TTA TTT GGC GGC GGG TTA GCC TTG AGC GCG CAA TTT TCT AAA ACC 1301Leu Leu Phe Gly Gly Gly Leu Ala Leu Ser Ala Gln Phe Ser Lys Thr
410 415 420GGG TTG AGT TTG TGG ATC GGG CAT TTA GTC TCT GGC TTT TCG CAT TTA 1349Gly Leu Ser Leu Trp Ile Gly His Leu ValSer Gly Phe Ser His Leu
425 430 435CCG ATT TTA TTC ATC ATT GTC ATG GTT ACT TTA ATG GTC ATT TTC TTA 1397Pro Ile Leu Phe Ile Ile Val Met Val Thr Leu Met Val Ile Phe Leu440 445450 455ACC GAA ATC ACT TCT AAC ACC GCC ACC GCT GCC GCA TTT TTA CCG GTG 1445Thr Glu Ile Thr Ser Asn Thr Ala Thr Ala Ala Ala Phe Leu Pro Val
460 465 470ATT GGA GGG GTT GCG ATG GGC ATG GGT TAT GAA AAC CAT CAG AGC TTG 1493Ile Gly Gly Val Ala Met Gly Met Gly Tyr Glu Asn His Gln Ser Leu
475 480 485TTA TTG ACC ATT CCT GTA GCC TTG AGT GCG ACT TGC GCG TTC ATG CTC 1541Leu Leu Thr Ile Pro Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu
490 495 500CCT GTG GTC ACC CCA CCG AAT GCA ATA GCT TAT GGC TCT GGG TAT GTT 1589Pro Val Val Thr Pro Pro Asn Ala Ile Ala Tyr Gly Ser Gly Tyr Val
505 510 515AAA ATA ACG GAC ATG ATT AAA GCC GGT TTG TGG CTT AAT CTG GTA GGA 1637Lys Ile Thr Asp Met Ile Lys Ala Gly Leu Trp Leu Asn Leu Val Gly520 525 530 535GTT GTT TTG ATT AGC ACG TTT AGC TAT TTT TTG GTT TCG TTA ATA TTT 1685Val Val Leu Ile Ser Thr Phe Ser Tyr Phe Leu Val Ser Leu Ile Phe
540 545 550AAT TGATTAAGGA AAAAAGTGAA AGAAGAGTTA TTTAAAGAAA AATCTCGTTA CATTAC 1744AsnAGGGTTTGTT TTAATC 1760
(2) Sequence 1230 data:
(i) sequence characteristics:
(A) length: 552 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1230: met Glu Asn His Ser His Ala Asn Thr His Thr Asp Thr Arg Thr Asp 151015 Asp Lys Ser Thr Lys Ile Val Arg Leu Leu Gly Leu Ile Gly Gly Ala
20 25 30Leu Ile Ala Leu Val Ile Tyr Tyr Ala Leu Asn Ser Gln Met Pro His
35 40 45Ile Val Glu Glu Ile Pro Lys Leu Ser Ser Leu Asn Tyr Lys Ala Met
50 55 60Pro Val Val Ala Gly Val Ala Val Leu Met Gly Ile Trp Trp Met Thr65 70 75 80Glu Ala Ile Asp Leu Pro Ala Thr Ala Leu Leu Pro Leu Val Leu Phe
85 90 95Ser Val Phe Ser Val Asp Gln Phe Ala Ser Val Ser Ser Ser Tyr Ala
100 105 110Ser Pro Ile Ile Phe Leu Phe Met Gly Gly Phe Ile Leu Ala Leu Ser
115 120 125Met Gln Lys Trp Asn Leu His Thr Arg Ile Ala Leu Ser Ile Ile Leu
130 135 140Leu Val Gly Thr Ser Pro Arg Arg Leu Ile Leu Gly Phe Met Met Ala145 150 155 160Thr Gly Phe Leu Ser Met Trp Val Ser Asn Thr Ala Thr Ala Val Met
165 170 175Met Leu Pro Val Gly Met Ser Val Leu Gln Leu Val Ala Lys Leu Val
180 185 190Gly Lys Glu Asp Ala Ser Asn Ser Trp His Gln Lys Glu Glu Ile Thr
195 200 205Lys Ala His Gly Gly Ile Met Ser Asn Ile Val His Lys Gly Lys Asp
210 215 220Ile Thr Gln Val Ile Gln Glu Lys Thr Thr Ile Tyr Arg Thr Asn Phe225 230 235 240Ser Ile Cys Leu Met Leu Gly Ile Ala Tyr Ala Ala Ser Ile Gly Ser
245 250 265Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Gly Tyr
260 265 270Met Lys Thr Ala Phe Asn Ile Glu Ile Asp Phe Ala Gln Trp Met Val
275 280 285Phe Gly Thr Pro Leu Ala Phe Ile Met Leu Ile Leu Ala Trp Leu Leu
290 295 300Leu Thr Tyr Val Ile Phe Pro Leu Lys Ile Lys Glu Ile Pro Gly Gly305 310 315 320Lys Glu Val Ile Arg Val Glu Leu Lys Lys Leu Gly Arg Leu Ser Gln
325 330 335Ala Glu Ile Ser Val Gly Ile Ile Phe Ile Leu Ala Ser Leu Gly Trp
340 345 350Ile Phe Leu Gly Val Met Leu Lys Ser Trp Gly Val Lys Ile Asp Lys
355 360 365Ile Asp Ser Val Ile Ala Met Gly Val Ser Ala Leu Leu Phe Ile Leu
370 375 380Pro Ala Asn His Gln Gly Asp Arg Leu Ile Asp Trp Gly Val Ala Lys385 390 395 400Lys Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ala Leu
405 410 415Ser Ala Gln Phe Ser Lys Thr Gly Leu Ser Leu Trp Ile Gly His Leu
420 425 430Val Ser Gly Phe Ser His Leu Pro Ile Leu Phe Ile Ile Val Met Val
435 440 445Thr Leu Met Val Ile Phe Leu Thr Glu Ile Thr Ser Asn Thr Ala Thr
450 455 460Ala Ala Ala Phe Leu Pro Val Ile Gly Gly Val Ala Met Gly Met Gly465 470 475 480Tyr Glu Asn His Gln Ser Leu Leu Leu Thr Ile Pro Val Ala Leu Ser
485 490 495Ala Thr Cys Ala Phe Met Leu Pro Val Val Thr Pro Pro Asn Ala Ile
500 505 510Ala Tyr Gly Ser Gly Tyr Val Lys Ile Thr Asp Met Ile Lys Ala Gly
515 520 525Leu Trp Leu Asn Leu Val Gly Val Val Leu Ile Ser Thr Phe Ser Tyr
530 535 540Phe Leu Val Ser Leu Ile Phe Asn545 550
(2) Sequence 1231 data:
(i) sequence characteristics:
(A) length: 661bp of 661bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 53...592
(D) Other information:
(xi) Description of the sequence: sequence 1231: GGTGGCGGCG TATTTTAACG GGCGTCCTAT AGAATGCGCT CTTATTAGCG CC ATG GTC 58
Met Val
1ATG GCT AGT GTT ATC GCT TAT CAA AAA GCG CAC CAT AGC GAA GCC ATT 106MetAla Ser Val Ile Ala Tyr Gln Lys Ala His His Ser Glu Ala Ile
5 10 15TTA CCC TTT TTG TAT CCG GGC GTT GGG TTT TTT GCG CTT TTT GGG GTT 154Leu Pro Phe Leu Tyr Pro Gly Val Gly Phe Phe Ala Leu Phe Gly Val
20 25 30TAT AAG GAT TTT GGT GCA GTA GCG ATC ATT TGG CTT TTA GTC GTG GTG 202Tyr Lys Asp Phe Gly Ala Val Ala Ile Ile Trp Leu Leu Val Val Val35 40 45 50GTT GCA AGC GAT GTG GGG GCG TTT TTT GGA GGC AAG CTT TTA GGC AAA 250Val Ala Ser Asp Val Gly Ala Phe Phe Gly Gly Lys Leu Leu Gly Lys
55 60 65ACC CCT TTC ACG CCC ACT TCG CCG AAT AAA ACC TTA GAG GGC GCG TTG 298Thr Pro Phe Thr Pro Thr Ser Pro Asn Lys Thr Leu Glu Gly Ala Leu
70 75 80ATT GGC GTG GTT TTG GCG AGC GTT TTA GGA TCG TTT GTG GGC ATG GGG 346Ile Gly Val Val Leu Ala Ser Val Leu Gly Ser Phe Val Gly Met Gly
85 90 95AAA TTG AGC GGA GGC TTT TTT ATG GCG CTC TTT TTT AGT TTT TTA ATC 394Lys Leu Ser Gly Gly Phe Phe Met Ala Leu Phe Phe Ser Phe Leu Ile
100 105 110GCT CTT GTG GCG GTG TTT GGG GAT TTG TAT GAA AGC TAT TTG AAA AGA 442Ala Leu Val Ala Val Phe Gly Asp Leu Tyr Glu Ser Tyr Leu Lys Arg115 120 125 130AAG GTC GGT ATC AAA GAT AGC GGT AAG ATT TTA CCC GGG CAT GGG GGC 490Lys Val Gly Ile Lys Asp Ser Gly Lys Ile Leu Pro Gly His Gly Gly
135 140 145GTT TTA GAC CGG TTG GAT TCC ATG CTT TTT GGG GCT TTA GGC TTG CAT 538Val Leu Asp Arg Leu Asp Ser Met Leu Phe Gly Ala Leu Gly Leu His
150 155 160GCG CTG TTG TAT TTT TTA GAA ATT TGG AAA GAA ACG GCG GTG TTT TTA 586Ala Leu Leu Tyr Phe Leu Glu Ile Trp Lys Glu Thr Ala Val Phe Leu
165 170 175GGG GAT TGAATGGTTG TTTTAGGAAG CACCGGCTCT ATTGGGAAAA ACGCCCTAAA AA 644Gly Asp
180TCGCAAAAAA ATTTGGC 661
(2) Sequence 1232 data:
(i) sequence characteristics:
(A) length: 180 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1232: met Val Met Ala Ser Val Ile Ala Tyr Gln Lys Ala His His Ser Glu 151015 Ala Ile Leu Pro Phe Leu Tyr Pro Gly Val Gly Phe Phe Ala Leu Phe
20 25 30Gly Val Tyr Lys Asp Phe Gly Ala Val Ala Ile Ile Trp Leu Leu Val
35 40 45Val Val Val Ala Ser Asp Val Gly Ala Phe Phe Gly Gly Lys Leu Leu
50 55 60Gly Lys Thr Pro Phe Thr Pro Thr Ser Pro Asn Lys Thr Leu Glu Gly65 70 75 80Ala Leu Ile Gly Val Val Leu Ala Ser Val Leu Gly Ser Phe Val Gly
85 90 95Met Gly Lys Leu Ser Gly Gly Phe Phe Met Ala Leu Phe Phe Ser Phe
100 105 110Leu Ile Ala Leu Val Ala Val Phe Gly Asp Leu Tyr Glu Ser Tyr Leu
115 120 125Lys Arg Lys Val Gly Ile Lys Asp Ser Gly Lys Ile Leu Pro Gly His
130 135 140Gly Gly Val Leu Asp Arg Leu Asp Ser Met Leu Phe Gly Ala Leu Gly145 150 155 160Leu His Ala Leu Leu Tyr Phe Leu Glu Ile Trp Lys Glu Thr Ala Val
165 170 175Phe Leu Gly Asp
180
(2) Sequence 1233 data:
(i) sequence characteristics:
(A) length: 1157bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 12...1115
(D) Other information:
(xi) Description of the sequence: sequence 1233: TAGGGGATTG A ATG GTT GTT TTA GGA AGC ACC GGC TCT ATT GGG AAA AAC 50
Met Val Val Leu Gly Ser Thr Gly Ser Ile Gly Lys Asn
1 5 10GCC CTA AAA ATC GCA AAA AAA TTT GGC ATA GAA ATA GAG GCC TTA AGC 98Ala Leu Lys Ile Ala Lys Lys Phe Gly Ile Glu Ile Glu Ala Leu Ser
15 20 25TGT GGG AAA AAT ATC GCT TTA ATC AAT GAA CAA ATC CAA GTT TTC AAA 146Cys Gly Lys Asn Ile Ala Leu Ile Asn Glu Gln Ile Gln Val Phe Lys30 35 40 45CCC AAG AAA GTG GCG ATT TTA GAT CCT AGC GAT TTG AAT GAT TTA GAG 194Pro Lys Lys Val Ala Ile Leu Asp Pro Ser Asp Leu Asn Asp Leu Glu
50 55 60CCT TTG GGT GCG GAA GTG TTT GTG GGG TTA GAG GGC ATT GAT GCG ATG 242Pro Leu Gly Ala Glu Val Phe Val Gly Leu Glu Gly Ile Asp Ala Met
65 70 75ATA GAA GAG TGC ACC TCA AAT TTA GTC CTT AAC GCC ATT GTG GGC GTG 290Ile Glu Glu Cys Thr Ser Asn Leu Val Leu Asn Ala Ile Val Gly Val
80 85 90GCA GGA TTG AAA GCG AGC TTT AAA AGC TTA CAA AGG AAT AAA AAA CTG 338Ala Gly Leu Lys Ala Ser Phe Lys Ser Leu Gln Arg Asn Lys Lys Leu
95 100 105GCC CTA GCG AAT AAA GAA AGC TTA GTG AGC GCG GGG CAT TTA TTA GAC 386Ala Leu Ala Asn Lys Glu Ser Leu Val Ser Ala Gly His Leu Leu Asp110 115 120 125ATT TCA CAA ATC ACG CCC ATT GAT AGC GAG CAT TTT GGT TTG TGG GCG 434Ile Ser Gln Ile Thr Pro Ile Asp Ser Glu His Phe Gly Leu Trp Ala
130 135 140TTG TTG CAA AAC AAG ACT TTA AAG CCT AAA TCC TTA ATC ATT AGC GCG 482Leu Leu Gln Asn Lys Thr Leu Lys Pro Lys Ser Leu Ile Ile Ser Ala
145 150 155AGT GGG GGG GCT TTC AGG GAC ACG CCT TTA GAA TTT ATT CCT ATT CAA 530Ser Gly Gly Ala Phe Arg Asp Thr Pro Leu Glu Phe Ile Pro Ile Gln
160 165 170AAC GCG CAA AAT GCG CTC AAG CAC CCT AAT TGG AGC ATG GGA TCT AAA 578Asn Ala Gln Asn Ala Leu Lys His Pro Asn Trp Ser Met Gly Ser Lys
175 180 185ATC ACC ATT GAT TCA GCG AGC ATG GTC AAT AAG CTT TTT GAA ATC CTA 626Ile Thr Ile Asp Ser Ala Ser Met Val Asn Lys Leu Phe Glu Ile Leu190 195 200 205GAA ACT TAT TGG CTT TTT GGC GCG TCT TTA AAG ATT GAT GCG CTG ATT 674Glu Thr Tyr Trp Leu Phe Gly Ala Ser Leu Lys Ile Asp Ala Leu Ile
210 215 220GAA AGG AGT TCT ATC GTG CAT GCT TTG GTG GAG TTT GAA GAC AAC TCT 722Glu Arg Ser Ser Ile Val His Ala Leu Val Glu Phe Glu Asp Asn Ser
225 230 235ATC ATC GCG CAT TTA GCG AGC GCA GAT ATG CAA TTA CCC ATA AGC TAT 770Ile Ile Ala His Leu Ala Ser Ala Asp Met Gln Leu Pro Ile Ser Tyr
240 245 250GCG ATC GAT CCG AAG TTG GCC TCT TTG AGC GCG TCT ATC AAG CCC TTA 818Ala Ile Asp Pro Lys Leu Ala Ser Leu Ser Ala Ser Ile Lys Pro Leu
255 260 265GAT CTA TAC GCT TTA AGC GCG ATT AAA TTT GAA CCC ATT AGC ATG GAG 866Asp Leu Tyr Ala Leu Ser Ala Ile Lys Phe Glu Pro Ile Ser Met Glu270 275 280 285CGC TAC ACT TTG TGG TGT TAT AAA GAC TTA CTG CTA GAA AAC CCT AAG 914Arg Tyr Thr Leu Trp Cys Tyr Lys Asp Leu Leu Leu Glu Asn Pro Lys
290 295 300CTT GGC GTG GTG CTG AAT GCG AGC AAT GAA GTG GCG ATG GAG AAG TTT 962Leu Gly Val Val Leu Asn Ala Ser Asn Glu Val Ala Met Glu Lys Phe
305 310 315TTA AAC AAA GAG ATC GCT TTT GGT GGC CTT ATC CAA ACC ATT TCT CAA 1010Leu Asn Lys Glu Ile Ala Phe Gly Gly Leu Ile Gln Thr Ile Ser Gln
320 325 330GCC TTA GAA TCA TAC GAT AAA ATG CCT TTC AAG CTC TCT AGT TTA GAA 1058Ala Leu Glu Ser Tyr Asp Lys Met Pro Phe Lys Leu Ser Ser Leu Glu
335 340 345GAA GTG CTG GAA TTA GAC AAA GAA GTT AGG GAG CGT TTT AAA AAT GTA 1106Glu Val Leu Glu Leu Asp Lys Glu Val Arg Glu Arg Phe Lys Asn Val350 355 360 365GCG GGA GTG TAGTATAATA AGATTTTGCT TCTAATAGCG TTTTATTTCA AT 1157Ala Gly Val
(2) Sequence 1234 material:
(i) sequence characteristics:
(A) length: 368 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1234: met Val Val Leu Gly Ser Thr Gly Ser Ile Gly Lys Asn Ala Leu Lys 151015 Ile Ala Lys Lys Phe Gly Ile Glu Ile Glu Ala Leu Ser Cys Gly Lys
20 25 30Asn Ile Ala Leu Ile Asn Glu Gln Ile Gln Val Phe Lys Pro Lys Lys
35 40 45Val Ala Ile Leu Asp Pro Ser Asp Leu Asn Asp Leu Glu Pro Leu Gly
50 55 60Ala Glu Val Phe Val Gly Leu Glu Gly Ile Asp Ala Met Ile Glu Glu65 70 75 80Cys Thr Ser Asn Leu Val Leu Asn Ala Ile Val Gly Val Ala Gly Leu
85 90 95Lys Ala Ser Phe Lys Ser Leu Gln Arg Asn Lys Lys Leu Ala Leu Ala
100 105 110Asn Lys Glu Ser Leu Val Ser Ala Gly His Leu Leu Asp Ile Ser Gln
115 120 125Ile Thr Pro Ile Asp Ser Glu His Phe Gly Leu Trp Ala Leu Leu Gln
130 135 140Asn Lys Thr Leu Lys Pro Lys Ser Leu Ile Ile Ser Ala Ser Gly Gly145 150 155 160Ala Phe Arg Asp Thr Pro Leu Glu Phe Ile Pro Ile Gln Asn Ala Gln
165 170 175Asn Ala Leu Lys His Pro Asn Trp Ser Met Gly Ser Lys Ile Thr Ile
180 185 190Asp Ser Ala Ser Met Val Asn Lys Leu Phe Glu Ile Leu Glu Thr Tyr
195 200 205Trp Leu Phe Gly Ala Ser Leu Lys Ile Asp Ala Leu Ile Glu Arg Ser
210 215 220Ser Ile Val His Ala Leu Val Glu Phe Glu Asp Asn Ser Ile Ile Ala225 230 235 240His Leu Ala Ser Ala Asp Met Gln Leu Pro Ile Ser Tyr Ala Ile Asp
245 250 255Pro Lys Leu Ala Ser Leu Ser Ala Ser Ile Lys Pro Leu Asp Leu Tyr
260 265 270Ala Leu Ser Ala Ile Lys Phe Glu Pro Ile Ser Met Glu Arg Tyr Thr
275 280 285Leu Trp Cys Tyr Lys Asp Leu Leu Leu Glu Asn Pro Lys Leu Gly Val
290 295 300Val Leu Asn Ala Ser Asn Glu Val Ala Met Glu Lys Phe Leu Asn Lys305 310 315 320Glu Ile Ala Phe Gly Gly Leu Ile Gln Thr Ile Ser Gln Ala Leu Glu
325 330 335Ser Tyr Asp Lys Met Pro Phe Lys Leu Ser Ser Leu Glu Glu Val Leu
340 345 350Glu Leu Asp Lys Glu Val Arg Glu Arg Phe Lys Asn Val Ala Gly Val
355 360 365
(2) Sequence 1235 data:
(i) sequence characteristics:
(A) length: 1025bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 22...999
(D) Other information:
(xi) Description of the sequence: sequence 1235: AAAGAATATA AAGGAATCAA A ATG GCA AAA CAT GAT TTA GTG GGT TCG GTT 51
Met Ala Lys His Asp Leu Val Gly Ser Val
1 5 10CTC TGG GAC GCA TAT TCT AAA GAA GTT CAA AGG CGC ATG GAC AAC CCC 99Leu Trp Asp Ala Tyr Ser Lys Glu Val Gln Arg Arg Met Asp Asn Pro
15 20 25ACG CAT TTA GGG GTC ATC ACC GAA GAG CAG GCT AAA GCC AAA AAC GCT 147Thr His Leu Gly Val Ile Thr Glu Glu Gln Ala Lys Ala Lys Asn Ala
30 35 40AAG CTC ATT GTG GCG GAT TAT GGC GCA GAG GCA TGC GGT GAT GCG GTG 195Lys Leu Ile Val Ala Asp Tyr Gly Ala Glu Ala Cys Gly Asp Ala Val
45 50 55AGG TTG TAT TGG CTT GTA GAT GAA AGC ACG GAT AGA ATT GTT GAC GCG 243Arg Leu Tyr Trp Leu Val Asp Glu Ser Thr Asp Arg Ile Val Asp Ala
60 6570AAG TTT AAA AGC TTT GGT TGC GGA ACA GCG ATC GCA AGC TCA GAC ATG 291Lys Phe Lys Ser Phe Gly Cys Gly Thr Ala Ile Ala Ser Ser Asp Met75 80 85 90ATG GTA GAG TTG TGC TTG AAT AAA AGA GTC CAA GAT GCG GTA AAA ATC 339Met Val Glu Leu Cys Leu Asn Lys Arg Val Gln Asp Ala Val Lys Ile
95 100 105ACG AAT TTA GAT GTG GAA AGA GGC TTG AGA GAC GAT CCG GAC ACG CCG 387Thr Asn Leu Asp Val Glu Arg Gly Leu Arg Asp Asp Pro Asp Thr Pro
110 115 120GCG GTG CCT GGG CAA AAA ATG CAC TGC TCG GTG ATG GCG TAT GAT GTG 435Ala Val Pro Gly Gln Lys Met His Cys Ser Val Met Ala Tyr Asp Val
125 130 135ATC AAA AAA GCT GCC GGC ATG TAT TTG GGG AAA AAC GCT GAA GAT TTT 483Ile Lys Lys Ala Ala Gly Met Tyr Leu Gly Lys Asn Ala Glu Asp Phe
140 145 150GAA GAA GAA ATC ATC GTG TGC GAG TGC GCT AGG GTG AGT TTA GGT ACG 531Glu Glu Glu Ile Ile Val Cys Glu Cys Ala Arg Val Ser Leu Gly Thr155 160 165 170ATT AAA GAA GTG ATT AAG CTC AAT GAT TTA AAA AGC GTT GAA GAA ATC 579Ile Lys Glu Val Ile Lys Leu Asn Asp Leu Lys Ser Val Glu Glu Ile
175 180 185ACT AAC TAC ACC AAA GCC GGT GCT TTT TGT AAA AGC TGT GTG AGG CCT 627Thr Asn Tyr Thr Lys Ala Gly Ala Phe Cys Lys Ser Cys Val Arg Pro
190 195 200GGA GGG CAT GAA AAA AGG GAT TAT TAC TTG GTG GAT ATT CTT AAA GAA 675Gly Gly His Glu Lys Arg Asp Tyr Tyr Leu Val Asp Ile Leu Lys Glu
205 210 215GTG CGC GAA GAA ATG GAA GCT GAA AAA CTT AAA GCG ACC GCT AATAAA 723Val Arg Glu Glu Met Glu Ala Glu Lys Leu Lys Ala Thr Ala Asn Lys
220 225 230TCC CAA AGC GGA GAA TTG GCT TTC AGG GAA ATG ACT ATG GTT CAA AAG 771Ser Gln Ser Gly Glu Leu Ala Phe Arg Glu Met Thr Met Val Gln Lys235 240 245 250ATT AAA GCG GTG GAT AAA GTC ATT GAT GAA AAT ATC CGC CCG ATG CTT 819Ile Lys Ala Val Asp Lys Val Ile Asp Glu Asn Ile Arg Pro Met Leu
255 260 265ATG ATG GAT GGA GGG GAT TTA GAG ATT TTA GAC ATT AAA GAA AGC GAT 867Met Met Asp Gly Gly Asp Leu Glu Ile Leu Asp Ile Lys Glu Ser Asp
270 275 280GAT TAC ATT GAT GTG TAT ATC CGC TAC ATG GGG GCA TGT GAT GGG TGC 915Asp Tyr Ile Asp Val Tyr Ile Arg Tyr Met Gly Ala Cys Asp Gly Cys
285 290 295ATG AGC GCG ACT ACC GGG ACT TTA TTT GCC ATT GAA AAC GCT TTG CAG 963Met Ser Ala Thr Thr Gly Thr Leu Phe Ala Ile Glu Asn Ala Leu Gln
300 305 310GAA TTA TTG GAT CGC AGT ATC AGG GTG TTA CCG ATT TGAACTTTTT AGGGGG 1015Glu Leu Leu Asp Arg Ser Ile Arg Val Leu Pro Ile315 320 325TGGAGGCCTT 1025
(2) Sequence 1236 data:
(i) sequence characteristics:
(A) length: 326 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1236: met Ala Lys His Asp Leu Val Gly Ser Val Leu Trp Asp Ala Tyr Ser 151015 Lys Glu Val Gln Arg Arg Met Asp Asn Pro Thr His Leu Gly Val Ile
20 25 30Thr Glu Glu Gln Ala Lys Ala Lys Asn Ala Lys Leu Ile Val Ala Asp
35 40 45Tyr Gly Ala Glu Ala Cys Gly Asp Ala Val Arg Leu Tyr Trp Leu Val
50 55 60Asp Glu Ser Thr Asp Arg Ile Val Asp Ala Lys Phe Lys Ser Phe Gly65 70 75 80Cys Gly Thr Ala Ile Ala Ser Ser Asp Met Met Val Glu Leu Cys Leu
85 90 95Asn Lys Arg Val Gln Asp Ala Val Lys Ile Thr Asn Leu Asp Val Glu
100 105 110Arg Gly Leu Arg Asp Asp Pro Asp Thr Pro Ala Val Pro Gly Gln Lys
115 120 125Met His Cys Ser Val Met Ala Tyr Asp Val Ile Lys Lys Ala Ala Gly
130 135 140Met Tyr Leu Gly Lys Asn Ala Glu Asp Phe Glu Glu Glu Ile Ile Val145 150 155 160Cys Glu Cys Ala Arg Val Ser Leu Gly Thr Ile Lys Glu Val Ile Lys
165 170 175Leu Asn Asp Leu Lys Ser Val Glu Glu Ile Thr Asn Tyr Thr Lys Ala
180 185 190Gly Ala Phe Cys Lys Ser Cys Val Arg Pro Gly Gly His Glu Lys Arg
195 200 205Asp Tyr Tyr Leu Val Asp Ile Leu Lys Glu Val Arg Glu Glu Met Glu
210 215 220Ala Glu Lys Leu Lys Ala Thr Ala Asn Lys Ser Gln Ser Gly Glu Leu225 230 235 240Ala Phe Arg Glu Met Thr Met Val Gln Lys Ile Lys Ala Val Asp Lys
245 250 255Val Ile Asp Glu Asn Ile Arg Pro Met Leu Met Met Asp Gly Gly Asp
260 265 270Leu Glu Ile Leu Asp Ile Lys Glu Ser Asp Asp Tyr Ile Asp Val Tyr
275 280 285Ile Arg Tyr Met Gly Ala Cys Asp Gly Cys Met Ser Ala Thr Thr Gly
290 295 300Thr Leu Phe Ala Ile Glu Asn Ala Leu Gln Glu Leu Leu Asp Arg Ser305 310 315 320Ile Arg Val Leu Pro Ile
325
(2) Sequence 1237 data:
(i) sequence characteristics:
(A) length: 414bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 19...375
(D) Other information:
(xi) Description of the sequence: sequence 1237: TAGAGCTTGA TTTTTTTA ATG TTA ATA ATG GAT TGG AAA TTA AAA GTG GTG 51
Met Leu Ile Met Asp Trp Lys Leu Lys Val Val
1 5 10AAA GAA ATC ATC ACC ATT ACC GCC ACA ACC GCC ACA ATG GGG ATC TTA 99Lys Glu Ile Ile Thr IleThr Ala Thr Thr Ala Thr Met Gly Ile Leu
15 20 25ACC ACA TAT TCA TTA AAC ACT AAT ATG AGC ACC ATT AAA GAA AAG CCG 147Thr Thr Tyr Ser Leu Asn Thr Asn Met Ser Thr Ile Lys Glu Lys Pro
30 35 40GCA AAA AAA GTA GAA AGC CTT GTT TTA GCC CCG GAT TTT GCG TTA ATG 195Ala Lys Lys Val Glu Ser Leu Val Leu Ala Pro Asp Phe Ala Leu Met
45 50 55ATA GAC TGC CCC ACT AAA GCG CAC CCT GTC ATT CCC CCC AAA AGC CCT 243Ile Asp Cys Pro Thr Lys Ala His Pro Val Ile Pro Pro Lys Ser Pro60 65 70 75GAG ATG ATA TTC CCC AAG CCT TGC GCT TTA GTT TCT TTA TTT TTA TCG 291Glu Met Ile Phe Pro Lys Pro Cys Ala Leu Val Ser Leu Phe Leu Ser
80 85 90CTC ACG CCG TCT TTT AAA ATC ACA TCT AAA GTT TTA GCC GTC AAT AAG 339Leu Thr Pro Ser Phe Lys Ile Thr Ser Lys Val Leu Ala Val Asn Lys
95 100 105CTT TCT ATC GTT CCC ACT AGT GCT AAA GAA AGA GCG TAAGGCAACA ACTCTA 391Leu Ser Ile Val Pro Thr Ser Ala Lys Glu Arg Ala
110 115TCATTATTTT AAAATCCAAA TTT 414
(2) Sequence 1238 data:
(i) sequence characteristics:
(A) length: 119 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1238: met Leu Ile Met Asp Trp Lys Leu Lys Val Val Lys Glu Ile Ile Thr 151015 Ile Thr Ala Thr Thr Ala Thr Met Gly Ile Leu Thr Thr Tyr Ser Leu
20 25 30Asn Thr Asn Met Ser Thr Ile Lys Glu Lys Pro Ala Lys Lys Val Glu
35 40 45Ser Leu Val Leu Ala Pro Asp Phe Ala Leu Met Ile Asp Cys Pro Thr
50 55 60Lys Ala His Pro Val Ile Pro Pro Lys Ser Pro Glu Met Ile Phe Pro65 70 75 80Lys Pro Cys Ala Leu Val Ser Leu Phe Leu Ser Leu Thr Pro Ser Phe
85 90 95Lys Ile Thr Ser Lys Val Leu Ala Val Asn Lys Leu Ser Ile Val Pro
100 105 110Thr Ser Ala Lys Glu Arg Ala
115
(2) Sequence 1239 data:
(i) sequence characteristics:
(A) length: 686bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...660
(D) Other information:
(xi) Description of the sequence: sequence 1239: TATAAGGTTG CTCTC ATG AAA AAA CCC TAT AGG AAG ATT TCT GAT TAT GCG 51
Met Lys Lys Pro Tyr Arg Lys Ile Ser Asp Tyr Ala
1 5 10ATC GTG GGT GGT TTG AGC GCG TTA GTG ATG GTG AGC ATT GTG GGG TGT 99Ile Val Gly Gly Leu Ser Ala Leu Val Met Val Ser Ile Val Gly Cys
15 20 25AAG AGC AAT GCT GAT GAC AAA CCA AAA GAG CAA AGC TCT TTA AGT CAA 147Lys Ser Asn Ala Asp Asp Lys Pro Lys Glu Gln Ser Ser Leu Ser Gln
30 35 40AGC GTT CAA AAA GGC GCG TTT GTG ATT TTA GAA GAG CAA AAG GAT AAA 195Ser Val Gln Lys Gly Ala Phe Val Ile Leu Glu Glu Gln Lys Asp Lys45 50 55 60TCT TAC AAG GTT GTT GAA GAA TAC CCC AGC TCA AGA ACC CAC ATT ATA 243Ser Tyr Lys Val Val Glu Glu Tyr Pro Ser Ser Arg Thr His Ile Ile
65 70 75GTG CGC GAT TTG CAA GGC AAT GAA CGC GTG TTA AGC AAT GAA GAG ATT 291Val Arg Asp Leu Gln Gly Asn Glu Arg Val Leu Ser Asn Glu Glu Ile
80 85 90CAA AAG CTC ATC AAA GAA GAA GAA GCT AAA ATT GAT AAC GGC ACG AGC 339Gln Lys Leu Ile Lys Glu Glu Glu Ala Lys Ile Asp Asn Gly Thr Ser
95 100 105AAG CTT GTC CAG CCT AAT AAT GGA GGG AGT AAT GAA GGC TCA GGC TTT 387Lys Leu Val Gln Pro Asn Asn Gly Gly Ser Asn Glu Gly Ser Gly Phe
110 115 120GGC TTG GGG AGC GCG ATT TTA GGG AGC GCG GCG GGG GCG ATT TTA GGG 435Gly Leu Gly Ser Ala Ile Leu Gly Ser Ala Ala Gly Ala Ile Leu Gly125 130 135 140AGT TAT ATT GGT AAT AAG CTT TTC AAT AAC CCT AAT TAC CAG CAA AAC 483Ser Tyr Ile Gly Asn Lys Leu Phe Asn Asn Pro Asn Tyr Gln Gln Asn
145 150 155GCC CAA CGG ACC TAC AAA TCC CCA CAA GCT TAC CAA CGC TCT CAA AAT 531AlaGln Arg Thr Tyr Lys Ser Pro Gln Ala Tyr Gln Arg Ser Gln Asn
160 165 170TCC TTT TCT AAA AGT GCG CCC AGT GCT TCA AGC ATG GGC GGA GCG AGT 579Ser Phe Ser Lys Ser Ala Pro Ser Ala Ser Ser Met Gly Gly Ala Ser
175 180 185AAG GGA CAG AGC GGG TTT TTT GGC TCT AGT AGG CCT ACT AGT TCA CCG 627Lys Gly Gln Ser Gly Phe Phe Gly Ser Ser Arg Pro Thr Ser Ser Pro
190 195 200GCG GTA AGC TCT GGG ACA AGG GGC TTT AAC TCA TAATTTAATT GATTCAAGGC 680Ala Val Ser Ser Gly Thr Arg Gly Phe Asn Ser205 210 215TAAAAA 686
(2) Sequence 1240 data:
(i) sequence characteristics:
(A) length: 215 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1240: met Lys Lys Pro Tyr Arg Lys Ile Ser Asp Tyr Ala Ile Val Gly Gly 151015 Leu Ser Ala Leu Val Met Val Ser Ile Val Gly Cys Lys Ser Asn Ala
20 25 30Asp Asp Lys Pro Lys Glu Gln Ser Ser Leu Ser Gln Ser Val Gln Lys
35 40 45Gly Ala Phe Val Ile Leu Glu Glu Gln Lys Asp Lys Ser Tyr Lys Val
50 55 60Val Glu Glu Tyr Pro Ser Ser Arg Thr His Ile Ile Val Arg Asp Leu65 70 75 80Gln Gly Asn Glu ArgVal Leu Ser Asn Glu Glu Ile Gln Lys Leu Ile
85 90 95Lys Glu Glu Glu Ala Lys Ile Asp Asn Gly Thr Ser Lys Leu Val Gln
100 105 110Pro Asn Asn Gly Gly Ser Asn Glu Gly Ser Gly Phe Gly Leu Gly Ser
115 120 125Ala Ile Leu Gly Ser Ala Ala Gly Ala Ile Leu Gly Ser Tyr Ile Gly
130 135 140Asn Lys Leu Phe Asn Asn Pro Asn Tyr Gln Gln Asn Ala Gln Arg Thr145 150 155 160Tyr Lys Ser Pro Gln Ala Tyr Gln Arg Ser Gln Asn Ser Phe Ser Lys
165 170 175Ser Ala Pro Ser Ala Ser Ser Met Gly Gly Ala Ser Lys Gly Gln Ser
180 185 190Gly Phe Phe Gly Ser Ser Arg Pro Thr Ser Ser Pro Ala Val Ser Ser
195 200 205Gly Thr Arg Gly Phe Asn Ser
210 215
(2) Data of sequence 1241:
(i) sequence characteristics:
(A) length: 1407bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...1362
(D) Other information:
(xi) Description ofthe sequence: sequence 1241: TTATAGGACT TTTTA ATG GAG TTA GAA ACT CAT TTG TCA AAA TAT TTC ACC 51
Met Glu Leu Glu Thr His Leu Ser Lys Tyr Phe Thr
1 5 10CTA GCC TTT ACG CAT AAA AGC ATG AGC TTA GAA ATG CGA GAA AAA CTC 99Leu Ala Phe Thr His Lys Ser Met Ser Leu Glu Met Arg Glu Lys Leu
15 20 25GCT ATT AAT TCG AAT GCA ACG CTT AAA GAA TTT TTA CAA ACC ATT AAA 147Ala Ile Asn Ser Asn Ala Thr Leu Lys Glu Phe Leu Gln Thr Ile Lys
30 35 40AAC CAT TGC CCT AAC ATC AAA GAG TGC ATG GTG TTA TCC ACA TGC AAT 195Asn His Cys Pro Asn Ile Lys Glu Cys Met Val Leu Ser Thr Cys Asn45 50 55 60CGC TTT GAA ATC TAT GCG AGC CTA AAA CAC GGC GCT AAT ACT AAT GAA 243Arg Phe Glu Ile Tyr Ala Ser Leu Lys His Gly Ala Asn Thr Asn Glu
65 70 75CAA AAA AAC GCA CTA TTA AAG ATT TTG GCT CAA AAT AAA AAA ATG AGC 291Gln Lys Asn Ala Leu Leu Lys Ile Leu Ala Gln Asn Lys Lys Met Ser
80 85 90GTG TCT GAT TTA GAA AAA TGC GTT TTA ATG AAC ACT GAT GAA AGC GCA 339Val Ser Asp Leu Glu Lys Cys Val Leu Met Asn Thr Asp Glu Ser Ala
95 100 105GTC CAT CAT GTC TTT AGC GTG TGC AGC AGT TTG GAT AGC TTG GTG GTT 387Val His His Val Phe Ser Val Cys Ser Ser Leu Asp Ser Leu Val Val
110 115 120GGG GAA ACT CAA ATC ACA GGG CAG ATG AAA AAC GCT TAT AAA TTC GCT 435Gly Glu Thr Gln Ile Thr Gly Gln Met Lys Asn Ala Tyr Lys Phe Ala125 130 135 140TTT GAA GAG AAA TTT TGC TCT AAAGAT TTA ACC CGA TTG CTC CAT TTT 483Phe Glu Glu Lys Phe Cys Ser Lys Asp Leu Thr Arg Leu Leu His Phe
145 150 155GCT TTC AAA TGC GCC GCT AAA GTG CGC AAT TTA ACC GGC ATT TCC AAG 531Ala Phe Lys Cys Ala Ala Lys Val Arg Asn Leu Thr Gly Ile Ser Lys
160 165 170CAA GGG GTT TCC ATC TCT TCA GTG GCG GTC AAA GAA GCG CTT AAT ATT 579Gln Gly Val Ser Ile Ser Ser Val Ala Val Lys Glu Ala Leu Asn Ile
175 180 185TTT GAA AAA GAA AGG ATT AAG GAT AAA AAA GCC CTT GTG ATA GGG CTT 627Phe Glu Lys Glu Arg Ile Lys Asp Lys Lys Ala Leu Val Ile Gly Leu
190 195 200GGC GAG ATG GCT CAA TTA GTC ATC AAG CAC CTT TTA AAC AAG CAA TTT 675Gly Glu Met Ala Gln Leu Val Ile Lys His Leu Leu Asn Lys Gln Phe205 210 215 220GAA GCG CTT ATC TTA GGG CGT AAT GCG GCT AAA TTT GAA GAT TTC ATC 723Glu Ala Leu Ile Leu Gly Arg Asn Ala Ala Lys Phe Glu Asp Phe Ile
225 230 235AAA GAA TTA GAA GAA CCT AAA AAA GTA AGC TTT CAA AAT ATA GAA AAT 771Lys Glu Leu Glu Glu Pro Lys Lys Val Ser Phe Gln Asn Ile Glu Asn
240 245 250TTA AAC GCT TAT ATC AAT GAA TAC GAA CTG CTT TTT TGC GCC ACT TCT 819Leu Asn Ala Tyr Ile Asn Glu Tyr Glu Leu Leu Phe Cys Ala Thr Ser
255 260 265TCG CCG CAT TTT ATC GTG CAA AAT CGC ATG TTA AAA GAA ACG ATT TTC 867Ser Pro His Phe Ile Val Gln Asn Arg Met Leu Lys Glu Thr Ile Phe
270 275 280AGG CGT TTT TGG TTT GAT TTA GCC GTG CCA CGG AAT ATT GAA AAG CCG 915Arg Arg Phe Trp Phe Asp Leu Ala Val Pro Arg Asn Ile Glu Lys Pro285 290 295 300GTA TTG GAT AAT ATT TTC TTA TAC AGC GTT GAT GAT TTA GAG CCT ATG 963Val Leu Asp Asn Ile Phe Leu Tyr Ser Val Asp Asp Leu Glu Pro Met
305 310 315GTG AGA GAA AAT GTG GAA AAC AGG CAA GAG AGC AGA ATG AGA GCT TAT 1011Val Arg Glu Asn Val Glu Asn Arg Gln Glu Ser Arg Met Arg Ala Tyr
320 325 330GAG ATT GTA GGG CTT GCC ACA ATG GAG TTT TAC CAA TGG ATT CAA AGT 1059Glu Ile Val Gly Leu Ala Thr Met Glu Phe Tyr Gln Trp Ile Gln Ser
335 340 345TTA GAA GTA GAG CCT GTG ATT AAG GAT TTA AGG GAA TTG GCT AGG ATT 1107Leu Glu Val Glu Pro Val Ile Lys Asp Leu Arg Glu Leu Ala Arg Ile
350 355 360TCA GCC CAA AAA GAA TTG CAA AAA GCG CTT AAA AAA CGC TAT GTG CCT 1155Ser Ala Gln Lys Glu Leu Gln Lys Ala Leu Lys Lys Arg Tyr Val Pro365 370 375 380AAA GAA TAC GAA AAC AAC ATT GAA AAG ATC TTG CAC AAC GCT TTC AAC 1203Lys Glu Tyr Glu Asn Asn Ile Glu Lys Ile Leu His Asn Ala Phe Asn
385 390 395ACT TTT TTG CAT AAC CCT ACC ATC GCC TTA AAA AAG AAC GCT CAA AAA 1251Thr Phe Leu His Asn Pro Thr Ile Ala Leu Lys Lys Asn Ala Gln Lys
400 405 410GAA GAA TCC GAT GTG CTT GTG GGT GCG ATT AAA AAC TTG TTT AAT TTA 1299Glu Glu Ser Asp Val Leu Val Gly Ala Ile Lys Asn Leu Phe Asn Leu
415 420 425GAC AAA TCT AAC GCT AAC CAT GCC CAG AAT TTG AAT CTC TAT AAA TGC 1347Asp Lys Ser Asn Ala Asn His Ala Gln Asn Leu Asn Leu Tyr Lys Cys
430 435 440GAA TAT TAC GAG GAA TAATGCATGC TATTTTCAAA ACTCTTTGCC CCCACTCTCA A 1403Glu Tyr Tyr Glu Glu445AGAA 1407
(2) Sequence 1242 data:
(i) sequence characteristics:
(A) length: 449 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1242: met Glu Leu Glu Thr His Leu Ser Lys Tyr Phe Thr Leu Ala Phe Thr 151015 His Lys Ser Met Ser Leu Glu Met Arg Glu Lys Leu Ala Ile Asn Ser
20 25 30Asn Ala Thr Leu Lys Glu Phe Leu Gln Thr Ile Lys Asn His Cys Pro
35 40 45Asn Ile Lys Glu Cys Met Val Leu Ser Thr Cys Asn Arg Phe Glu Ile
50 55 60Tyr Ala Ser Leu Lys His Gly Ala Asn Thr Asn Glu Gln Lys Asn Ala65 70 75 80Leu Leu Lys Ile Leu Ala Gln Asn Lys Lys Met Ser Val Ser Asp Leu
85 90 95Glu Lys Cys Val Leu Met Asn Thr Asp Glu Ser Ala Val His His Val
100 105 110Phe Ser Val Cys Ser Ser Leu Asp Ser Leu Val Val Gly Glu Thr Gln
115 120 125Ile Thr Gly Gln Met Lys Asn Ala Tyr Lys Phe Ala Phe Glu Glu Lys
130 135 140Phe Cys Ser Lys Asp Leu Thr Arg Leu Leu His Phe Ala Phe Lys Cys145 150 155 160Ala Ala Lys Val Arg Asn Leu Thr Gly Ile Ser Lys Gln Gly Val Ser
165 170 175Ile Ser Ser Val Ala Val Lys Glu Ala Leu Asn Ile Phe Glu Lys Glu
180 185 190Arg Ile Lys Asp Lys Lys Ala Leu Val Ile Gly Leu Gly Glu Met Ala
195 200 205Gln Leu Val Ile Lys His Leu Leu Asn Lys Gln Phe Glu Ala Leu Ile
210 215 220Leu Gly Arg Asn Ala Ala Lys Phe Glu Asp Phe Ile Lys Glu Leu Glu225 230 235 240Glu Pro Lys Lys Val Ser Phe Gln Asn Ile Glu Asn Leu Asn Ala Tyr
245 250 255Ile Asn Glu Tyr Glu Leu Leu Phe Cys Ala Thr Ser Ser Pro His Phe
260 265 270Ile Val Gln Asn Arg Met Leu Lys Glu Thr Ile Phe Arg Arg Phe Trp
275 280 285Phe Asp Leu Ala Val Pro Arg Asn Ile Glu Lys Pro Val Leu Asp Asn
290 295 300Ile Phe Leu Tyr Ser Val Asp Asp Leu Glu Pro Met Val Arg Glu Asn305 310 315 320Val Glu Asn Arg Gln Glu Ser Arg Met Arg Ala Tyr Glu Ile Val Gly
325 330 335Leu Ala Thr Met Glu Phe Tyr Gln Trp Ile Gln Ser Leu Glu Val Glu
340 345 350Pro Val Ile Lys Asp Leu Arg Glu Leu Ala Arg Ile Ser Ala Gln Lys
355 360 365Glu Leu Gln Lys Ala Leu Lys Lys Arg Tyr Val Pro Lys Glu Tyr Glu
370 375 380Asn Asn Ile Glu Lys Ile Leu His Asn Ala Phe Asn Thr Phe Leu His385 390 395 400Asn Pro Thr Ile Ala Leu Lys Lys Asn Ala Gln Lys Glu Glu Ser Asp
405 410 415Val Leu Val Gly Ala Ile Lys Asn Leu Phe Asn Leu Asp Lys Ser Asn
420 425 430Ala Asn His Ala Gln Asn Leu Asn Leu Tyr Lys Cys Glu Tyr Tyr Glu
435 440 445Glu
(2) Sequence 1243 data:
(i) sequence characteristics:
(A) length: 1202bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 40...1125
(D) Other information:
(xi) Description of the sequence: sequence 1243: AAAACCCAAA CGCCGTTAAA ATATTTAAAA AGGAAATTC ATG CCC ATT GAT TTG 54
Met Pro Ile Asp Leu
1 5AAC GAA CAT TTA AAA AAG AAA AAT TCT CAA AGA GAA ACC CCC ACG CCT 102Asn Glu His Leu Lys Lys Lys Asn Ser Gln Arg Glu Thr Pro Thr Pro
10 15 20AAT ACG CCT AAT AAT GGG GGG CGT TTC ATC CCG CCG TCT AAT TCT TTT 150Asn Thr Pro Asn Asn Gly Gly Arg Phe Ile Pro Pro Ser Asn Ser Phe
25 30 35AAT TCT AAA AAA CTA TCG GTT TTA ATT GTC ATT GTC CTT TTA GGC GTT 198Asn Ser Lys Lys Leu Ser Val Leu Ile Val Ile Val Leu Leu Gly Val
40 45 50ATC GCT TTT TTG GCC AAG CCT TTT GAA GTG ATT AGC TCA GGA GAA ATT 246Ile Ala Phe Leu Ala Lys Pro Phe Glu Val Ile Ser Ser Gly Glu Ile
55 60 65GGC ATT AAA ATC ACC GCC GGG AAA TAC GAA CCC ACC CCC TTA CAG CCA 294Gly Ile Lys Ile Thr Ala Gly Lys Tyr Glu Pro Thr Pro Leu Gln Pro70 75 80 85GGG ATC CAC TTC TTT GTG CCT ATC ATT CAA GAC ATT CTC ATT GTG GAT 342Gly Ile His Phe Phe Val Pro Ile Ile Gln Asp Ile Leu Ile Val Asp
90 95 100ACA AGG ATT AGG AAT ATC AAT TTT TCA CGC ACC GAA GAC ATG GGC GTG 390Thr Arg Ile Arg Asn Ile Asn Phe Ser Arg Thr Glu Asp Met Gly Val
105 110 115GCG GGT AAA AAC CAA GGG ATT TTT AGA AAC GAC GCT ATT AAT GTG ATG 438Ala Gly Lys Asn Gln Gly Ile Phe Arg Asn Asp Ala Ile Asn Val Met
120 125 130GAT AGT AGG GGT TTG ACC GTT TCT ATT GAA CTC ACC GTG CAA TAC CGC 486Asp Ser Arg Gly Leu Thr Val Ser Ile Glu Leu Thr Val Gln Tyr Arg
135 140 145TTA AAC CCC CAA ACC ACC CCC CAA ACG ATC GCT ACT TAT GGC TTG TCT 534Leu Asn Pro Gln Thr Thr Pro Gln Thr Ile Ala Thr Tyr Gly Leu Ser150 155 160 165TGG GAG CAA AAA ATC ATC AAC CCT GTG GTG CGC GAT GTG GTG CGC TCT 582Trp Glu Gln Lys Ile Ile Asn Pro Val Val Arg Asp Val Val Arg Ser
170 175 180GTC GTG GGG CGC TAT CCG GCT GAA GAT TTA CCC ATT AAG CGC AAT GAA 630Val Val Gly Arg Tyr Pro Ala Glu Asp Leu Pro Ile Lys Arg Asn Glu
185 190 195ATC GCC GCT CTT ATT AAT AGC GGT ATC AAT AAA GAA GTT TCT AAG CTC 678Ile Ala Ala Leu Ile Asn Ser Gly Ile Asn Lys Glu Val Ser Lys Leu
200 205 210CCT AAC ACC CCT GTG GAA TTA AGC TCT ATC CAA TTG AGA GAA ATC GTC 726Pro Asn Thr Pro Val Glu Leu Ser Ser Ile Gln Leu Arg Glu Ile Val
215 220 225TTG CCC GCT AAG ATT AAA GAG CAA ATA GAA AAA GTC CAA ATC GCG CGC 774Leu Pro Ala Lys Ile Lys Glu Gln Ile Glu Lys Val Gln Ile Ala Arg230 235 240 245CAA GAA TCA GAA AGG GTG AAA TAC GAG GTG GAG CGC TCC AAG CAA GAA 822Gln Glu Ser Glu Arg Val Lys Tyr Glu Val Glu Arg Ser Lys Gln Glu
250 255 260GCT CAA AAA CAA GCC GCT CTG GCT AAA GGG GAA GCG GAC GCT AAC AGG 870Ala Gln Lys Gln Ala Ala Leu Ala Lys Gly Glu Ala Asp Ala Asn Arg
265 270 275ATT AAG GCT CAG GGC GTG GCT GAT GCG ATT GTG ATT GAG GCT AAG GCA 918Ile Lys Ala Gln Gly Val Ala Asp Ala Ile Val Ile Glu Ala Lys Ala
280 285 290AAA TCT CAA GCT AAT TTA AGC ATT TCG CAA AGC TTG AGC GAC AAG CTT 966Lys Ser Gln Ala Asn Leu Ser Ile Ser Gln Ser Leu Ser Asp Lys Leu
295 300 305TTA AGA CTG CGC CAA ATT GAA GTT CAA GGC CAG TTT AAT GAA GCG TTA 1014Leu Arg Leu Arg Gln Ile Glu Val Gln Gly Gln Phe Asn Glu Ala Leu310 315320 325AAA ACG AAC AAT AAC GCT CAA ATC ATG CTC ACT CCA GGT GGG GCT GTG 1062Lys Thr Asn Asn Asn Ala Gln Ile Met Leu Thr Pro Gly Gly Ala Val
330 335 340CCT AAT ATT TGG ATT GAC ACT AAA AGC AAG GTT AAA TCT AGT ATT GCC 1110Pro Asn Ile Trp Ile Asp Thr Lys Ser Lys Val Lys Ser Ser Ile Ala
345 350 355GAG ACT AAA GAG CCT TAAAAACGCA TGGCATCTCT TGCCTTTATC CAAGCTTTTT T 1166Glu Thr Lys Glu Pro
360GGAGTCTTTT AAGGGATTTT TAAGTCAAGC GACTCT 1202
(2) Sequence 1244 data:
(i) sequence characteristics:
(A) length: 362 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1244: met Pro Ile Asp Leu Asn Glu His Leu Lys Lys Lys Asn Ser Gln Arg 151015 Glu Thr Pro Thr Pro Asn Thr Pro Asn Asn Gly Gly Arg Phe Ile Pro
20 25 30Pro Ser Asn Ser Phe Asn Ser Lys Lys Leu Ser Val Leu Ile Val Ile
35 40 45Val Leu Leu Gly Val Ile Ala Phe Leu Ala Lys Pro Phe Glu Val Ile
50 55 60Ser Ser Gly Glu Ile Gly Ile Lys Ile Thr Ala Gly Lys Tyr Glu Pro65 70 75 80Thr Pro Leu Gln Pro Gly Ile His Phe Phe Val Pro Ile Ile Gln Asp
85 90 95Ile LeuIle Val Asp Thr Arg Ile Arg Asn Ile Asn Phe Ser Arg Thr
100 105 110Glu Asp Met Gly Val Ala Gly Lys Asn Gln Gly Ile Phe Arg Asn Asp
115 120 125Ala Ile Asn Val Met Asp Ser Arg Gly Leu Thr Val Ser Ile Glu Leu
130 135 140Thr Val Gln Tyr Arg Leu Asn Pro Gln Thr Thr Pro Gln Thr Ile Ala145 150 155 160Thr Tyr Gly Leu Ser Trp Glu Gln Lys Ile Ile Asn Pro Val Val Arg
165 170 175Asp Val Val Arg Ser Val Val Gly Arg Tyr Pro Ala Glu Asp Leu Pro
180 185 190Ile Lys Arg Asn Glu Ile Ala Ala Leu Ile Asn Ser Gly Ile Asn Lys
195 200 205Glu Val Ser Lys Leu Pro Asn Thr Pro Val Glu Leu Ser Ser Ile Gln
210 215 220Leu Arg Glu Ile Val Leu Pro Ala Lys Ile Lys Glu Gln Ile Glu Lys225 230 235 240Val Gln Ile Ala Arg Gln Glu Ser Glu Arg Val Lys Tyr Glu Val Glu
245 250 255Arg Ser Lys Gln Glu Ala Gln Lys Gln Ala Ala Leu Ala Lys Gly Glu
260 265 270Ala Asp Ala Asn Arg Ile Lys Ala Gln Gly Val Ala Asp Ala Ile Val
275 280 285Ile Glu Ala Lys Ala Lys Ser Gln Ala Asn Leu Ser Ile Ser Gln Ser
290 295 300Leu Ser Asp Lys Leu Leu Arg Leu Arg Gln Ile Glu Val Gln Gly Gln305 310 315 320Phe Asn Glu Ala Leu Lys Thr Asn Asn Asn Ala Gln Ile Met Leu Thr
325 330 335Pro Gly Gly Ala Val Pro Asn Ile Trp Ile Asp Thr Lys Ser Lys Val
340 345 350Lys Ser Ser Ile Ala Glu Thr Lys Glu Pro
355 360
(2) Sequence 1245 data:
(i) sequence characteristics:
(A) length: 630bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 23...559
(D) Other information:
(xi) Description of the sequence: sequence 1245: GACTAAAGAG CCTTAAAAAC GC ATG GCA TCT CTT GCC TTT ATC CAA GCT TTT 52
Met Ala Ser Leu Ala Phe Ile Gln Ala Phe
1 5 10TTG GAG TCT TTT AAG GGA TTT TTA AGT CAA GCG ACT CTA ATC AGC GTT 100Leu Glu Ser Phe Lys Gly Phe Leu Ser Gln Ala Thr Leu Ile Ser Val
15 20 25TTA ATA GCG AGC GTT TTA ATC CTT TTT TGC GCG ATT TTG CTC CTT TTG 148Leu Ile Ala Ser Val Leu Ile Leu Phe Cys Ala Ile Leu Leu Leu Leu
30 35 40GCT CTG CTT TTG AGA AAC CGC TTA GCT AGC TAT ATA GCA ACA GCA GCT 196Ala Leu Leu Leu Arg Asn Arg Leu Ala Ser Tyr Ile Ala ThrAla Ala
45 50 55TTT TTG GGT GCG TTT TTA AGC ATG CCT TTT GTT TTG AAC ATT TTA CTC 244Phe Leu Gly Ala Phe Leu Ser Met Pro Phe Val Leu Asn Ile Leu Leu
60 65 70ACT CAA GCG ATT TAC CCC ATA GAA ACA CGC ATC TTA CAC GCT AAC CCT 292Thr Gln Ala Ile Tyr Pro Ile Glu Thr Arg Ile Leu His Ala Asn Pro75 80 85 90TTA AGT TAC AGC AAC GCC TTT TCT TTG CAA GTG GGA GTC AAA AAC CAT 340Leu Ser Tyr Ser Asn Ala Phe Ser Leu Gln Val Gly Val Lys Asn His
95 100 105TCC AAA TTT ACT CTA AAC AAA TGC GTT TTA CGC CTA GAA GTG CTT AAA 388Ser Lys Phe Thr Leu Asn Lys Cys Val Leu Arg Leu Glu Val Leu Lys
110 115 120AAC CCT CAC AAT TTT GTA GAA GAG CAT GCT TTT AAA TGG TTT GTC AAA 436Asn Pro His Asn Phe Val Glu Glu His Ala Phe Lys Trp Phe Val Lys
125 130 135AAA AGC TAT GAA AAA ATT TTT AAA GAA AAG ATT TTG CCC AAA GAA TCT 484Lys Ser Tyr Glu Lys Ile Phe Lys Glu Lys Ile Leu Pro Lys Glu Ser
140 145 150AAG GTC TTT TCA TTC TTT ATT GAC AAC TAC CCT TAT TCA AAA ACG GCC 532Lys Val Phe Ser Phe Phe Ile Asp Asn Tyr Pro Tyr Ser Lys Thr Ala155 160 165 170CCT TAT CAA GTT TCT TTG TTT TGT TTA TAAAAAACTA AAAGATAACG CCCAAGA 586Pro Tyr Gln Val Ser Leu Phe Cys Leu
175TAACATTCAT TAAAAAGCGA TTAAAAACGC TTAAAGGCAT AGAT 630
(2) Sequence 1246 data:
(i) sequence characteristics:
(A) length: 179 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1246: met Ala Ser Leu Ala Phe Ile Gln Ala Phe Leu Glu Ser Phe Lys Gly 151015 Phe Leu Ser Gln Ala Thr Leu Ile Ser Val Leu Ile Ala Ser Val Leu
20 25 30Ile Leu Phe Cys Ala Ile Leu Leu Leu Leu Ala Leu Leu Leu Arg Asn
35 40 45Arg Leu Ala Ser Tyr Ile Ala Thr Ala Ala Phe Leu Gly Ala Phe Leu
50 55 60Ser Met Pro Phe Val Leu Asn Ile Leu Leu Thr Gln Ala Ile Tyr Pro65 70 75 80Ile Glu Thr Arg Ile Leu His Ala Asn Pro Leu Ser Tyr Ser Asn Ala
85 90 95Phe Ser Leu Gln Val Gly Val Lys Asn His Ser Lys Phe Thr Leu Asn
100 105 110Lys Cys Val Leu Arg Leu Glu Val Leu Lys Asn Pro His Asn Phe Val
115 120 125Glu Glu His Ala Phe Lys Trp Phe Val Lys Lys Ser Tyr Glu Lys Ile
130 135 140Phe Lys Glu Lys Ile Leu Pro Lys Glu Ser Lys Val Phe Ser Phe Phe145 150 155 160Ile Asp Asn Tyr Pro Tyr Ser Lys Thr Ala Pro Tyr Gln Val Ser Leu
165 170 175Phe Cys Leu
(2) Sequence 1247 data:
(i) sequence characteristics:
(A) length: 1350bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 47...1273
(D) Other information:
(xi) Description of the sequence: sequence 1247: AAAGAATGAT CTTAAAAGGG CAAACCACAT TTATTAAGGA GAATGC ATG CAA GAA 55
Met Gln Glu
1ATC ATA GGA GCG TCT TTA GTT TTT TTG TGC AAT GAA AAG TGC GAA GTG 103Ile Ile Gly Ala Ser Leu Val Phe Leu Cys Asn Glu Lys Cys Glu Val
5 10 15TTA GAA GAT TAT GGC GTA GTC TTT GAT GAA AAG ATT GTT GAA ATA GGC 151Leu Glu Asp Tyr Gly Val Val Phe Asp Glu Lys Ile Val Glu Ile Gly20 25 30 35GAT TAT CAA AGT TTA ACG CTT AAA TAC CCT CAC TTA AAG GCG CAG TTT 199Asp Tyr Gln Ser Leu Thr Leu Lys Tyr Pro His Leu Lys Ala Gln Phe
40 45 50TTT GAA AAT TCC GTT CTG TTG CCC GCT TTT ATC AAC GCG CAC ACC CAT 247Phe Glu Asn Ser Val Leu Leu Pro Ala Phe Ile Asn Ala His Thr His
55 60 65TTT GAA TTT TCC AAC AAC AAG GCG AGT TTT GAT TAC GGG AGT TTT TCT 295Phe Glu Phe Ser Asn Asn Lys Ala Ser Phe Asp Tyr Gly Ser Phe Ser
70 75 80GGC TGG TTA GGG AGC GTG TTA AAC AAT GGG GGG GCG ATT TTA GAA AAT 343Gly Trp Leu Gly Ser Val Leu Asn Asn Gly Gly Ala Ile Leu Glu Asn
85 90 95TGC CAA GGG GCT ATT CAA AAC GCT ATC AGC ACG CAA TTA AAA AGC GGG 391Cys Gln Gly Ala Ile Gln Asn Ala Ile Ser Thr Gln Leu Lys Ser Gly100 105 110 115GTG GGG AGC GTG GGA GCG ATT TCT AAC CAC CTG ATA GAA GTT AAT TTG 439Val Gly Ser Val Gly Ala Ile Ser Asn His Leu Ile Glu Val Asn Leu
120 125 130TTA AAA GAA AGC CCT TTG AAT GCT GTC GTG TTT TTA GAG TTT TTA GGG 487Leu Lys Glu Ser Pro Leu Asn Ala Val Val Phe Leu Glu Phe Leu Gly
135 140 145AGC AGT TAT TCT TTA GAA AAA TTA AAA GCG TTT GAG GCC AAA TTT AAG 535Ser Ser Tyr Ser Leu Glu Lys Leu Lys Ala Phe Glu Ala Lys Phe Lys
150 155 160GAA TTA AAA GAT TTA GAA GAT AAA AAA CTT AAA GCG GCT CTC GCT GTG 583Glu Leu Lys Asp Leu Glu Asp Lys Lys Leu Lys Ala Ala Leu Ala Val
165 170 175CAT GCC CCT TAT TCG GTC CAA AAA GAC ATG GCT TTG AGC GTC ATC CAA 631His Ala Pro Tyr Ser Val Gln Lys Asp Met Ala Leu Ser Val Ile Gln180 185 190 195TTA GCC AAA GAT TCA CAA AGC CTG CTT TCT ACG CAT TTT TTA GAA TCG 679Leu Ala Lys Asp Ser Gln Ser Leu Leu Ser Thr His Phe Leu Glu Ser
200 205 210CTT GAA GAA TTA GAA TGG GTA GAA AAC TCT AAA GGG TGG TTT GAA AAT 727Leu Glu Glu Leu Glu Trp Val Glu Asn Ser Lys Gly Trp Phe Glu Asn
215 220 225TTT TAC CAG CAT TTT TTA AAG GAG TCT CAT TTC AAA TCG CTC TAT AAG 775Phe Tyr Gln His Phe Leu Lys Glu Ser His Phe Lys Ser Leu Tyr Lys
230 235 240GGC GCG AAC GAT TAC ATT GAC ATG TTT AAA GAC ACG CAC ACT TTA TTC 823Gly Ala Asn Asp Tyr Ile Asp Met Phe Lys Asp Thr His Thr Leu Phe
245 250 255GTG CAT AAC CAG TTC GCT TCT TTA GAA GCG TTA AAA AGG ATT AAA TCT 871Val His Asn Gln Phe Ala Ser Leu Glu Ala Leu Lys Arg Ile Lys Ser260 265 270 275CAA GTC AAA AAC GCT TTT TTA ATC ACA TGC CCC TTT TCT AAC CGC CTA 919Gln Val Lys Asn Ala Phe Leu Ile Thr Cys Pro Phe Ser Asn Arg Leu
280 285 290TTG AGC GGG CAA GCG TTG GAT TTA GAA AGA ACT AAA GAA GCC GGT TTG 967Leu Ser Gly Gln Ala Leu Asp Leu Glu Arg Thr Lys Glu Ala Gly Leu
295 300 305AGC GTG AGC GTG GCC ACT GAT GGC TTG AGT TCT AAC ATT TCG CTG AGC 1015Ser Val Ser Val Ala Thr Asp Gly Leu Ser Ser Asn Ile Ser Leu Ser
310 315 320CTT TTA GAC GAA TTA AGA GCG TTT TTG CTC ACC CAT AAC ATG CCG TTA 1063Leu Leu Asp Glu Leu Arg Ala Phe Leu Leu Thr His Asn Met Pro Leu
325 330 335TTA GAA TTA GCT AAA ATA GCC CTT TTA GGG GCG ACT AGG CAT GGG GCT 1111Leu Glu Leu Ala Lys Ile Ala Leu Leu Gly Ala Thr Arg His Gly Ala340 345 350 355AAA GCT TTA GCT TTG AAT AAT GGC GAG ATA GAA GCC AAC AAA AGG GCG 1159Lys Ala Leu Ala Leu Asn Asn Gly Glu Ile Glu Ala Asn Lys Arg Ala
360 365 370GAT TTG AGC GTG TTT GGT TTT AAT GAA AAA TTC ACT AAA GAG CAA GCG 1207Asp Leu Ser Val Phe Gly Phe Asn Glu Lys Phe Thr Lys Glu Gln Ala
375 380 385ATT TTG CAA TTT TTA TTG CAT GCT AAA GAA GTG GAG TGC TTG TTT TTA 1255Ile Leu Gln Phe Leu Leu His Ala Lys Glu Val Glu Cys Leu Phe Leu
390 395 400GGG GGG AAA AGG GTG ATC TAATTTGTTT TAAAGACAGA ATGCGTTAAA ATGAGAAA 1311Gly Gly Lys Arg Val Ile
405TCTAAATCAA TTAAGGAAAG AGTCAATGAA ACTAGTTTT 1350
(2) Sequence 1248 data:
(i) sequence characteristics:
(A) length: 409 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1248: met Gln Glu Ile Ile Gly Ala Ser Leu Val Phe Leu Cys Asn Glu Lys 151015 Cys Glu Val Leu Glu Asp Tyr Gly Val Val Phe Asp Glu Lys Ile Val
20 25 30Glu Ile Gly Asp Tyr Gln Ser Leu Thr Leu Lys Tyr Pro His Leu Lys
35 40 45Ala Gln Phe Phe Glu Asn Ser Val Leu Leu Pro Ala Phe Ile Asn Ala
50 55 60His Thr His Phe Glu Phe Ser Asn Asn Lys Ala Ser Phe Asp Tyr Gly65 70 75 80Ser Phe Ser Gly Trp Leu Gly Ser Val Leu Asn Asn Gly Gly Ala Ile
85 90 95Leu Glu Asn Cys Gln Gly Ala Ile Gln Asn Ala Ile Ser Thr Gln Leu
100 105 110Lys Ser Gly Val Gly Ser Val Gly Ala Ile Ser Asn His Leu Ile Glu
115 120 125Val Asn Leu Leu Lys Glu Ser Pro Leu Asn Ala Val Val Phe Leu Glu
130 135 140Phe Leu Gly Ser Ser Tyr Ser Leu Glu Lys Leu Lys Ala Phe Glu Ala145 150 155 160Lys Phe Lys Glu Leu Lys Asp Leu Glu Asp Lys Lys Leu Lys Ala Ala
165 170 175Leu Ala Val His Ala Pro Tyr Ser Val Gln Lys Asp Met Ala Leu Ser
180 185 190Val Ile Gln Leu Ala Lys Asp Ser Gln Ser Leu Leu Ser Thr His Phe
195 200 205Leu Glu Ser Leu Glu Glu Leu Glu Trp Val Glu Asn Ser Lys Gly Trp
210 215 220Phe Glu Asn Phe Tyr Gln His Phe Leu Lys Glu Ser His Phe Lys Ser225 230 235 240Leu Tyr Lys Gly Ala Asn Asp Tyr Ile Asp Met Phe Lys Asp Thr His
245 250 255Thr Leu Phe Val His Asn Gln Phe Ala Ser Leu Glu Ala Leu Lys Arg
260 265 270Ile Lys Ser Gln Val Lys Asn Ala Phe Leu Ile Thr Cys Pro Phe Ser
275 280 285Asn Arg Leu Leu Ser Gly Gln Ala Leu Asp Leu Glu Arg Thr Lys Glu
290 295 300Ala Gly Leu Ser Val Ser Val Ala Thr Asp Gly Leu Ser Ser Asn Ile305 310 315 320Ser Leu Ser Leu Leu Asp Glu Leu Arg Ala Phe Leu Leu Thr His Asn
325 330 335Met Pro Leu Leu Glu Leu Ala Lys Ile Ala Leu Leu Gly Ala Thr Arg
340 345 350His Gly Ala Lys Ala Leu Ala Leu Asn Asn Gly Glu Ile Glu Ala Asn
355 360 365Lys Arg Ala Asp Leu Ser Val Phe Gly Phe Asn Glu Lys Phe Thr Lys
370 375 380Glu Gln Ala Ile Leu Gln Phe Leu Leu His Ala Lys Glu Val Glu Cys385 390 395 400Leu Phe Leu Gly Gly Lys Arg Val Ile
405
(2) Sequence 1249 data:
(i) sequence characteristics:
(A) length: 1356bp of
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 31...1320
(D) Other information:
(xi) Description of the sequence: sequence 1249: AGGCTTGTAT TGAAAGTTTA TATTGAAACC ATG GGT TGT GCC ATG AAT TCT AGG 54
Met Gly Cys Ala Met Asn Ser Arg
1 5GAT AGT GAG CAT TTA TTG AGC GAG CTG TCC AAA CTA GAC TAT AAA GAG 102Asp Ser Glu His Leu Leu Ser Glu Leu Ser Lys Leu Asp Tyr Lys Glu
10 15 20ACC AAT GAC CCT AAA ACA GCG GAT TTG ATT TTA ATC AAC ACT TGC AGC 150Thr Asn Asp Pro Lys Thr Ala Asp Leu Ile Leu Ile Asn Thr Cys Ser25 30 3540GTG CGC GAA AAG CCT GAA CGA AAA TTG TTT TCA GAA ATC GGT CAA TTC 198Val Arg Glu Lys Pro Glu Arg Lys Leu Phe Ser Glu Ile Gly Gln Phe
45 50 55GCT AAA ATC AAA AAA CCC AAC GCC AAA ATC GGG GTT TGC GGG TGC ACT 246Ala Lys Ile Lys Lys Pro Asn Ala Lys Ile Gly Val Cys Gly Cys Thr
60 65 70GCA AGC CAC ATG GGA GCG GAT ATT TTG AAA AAA GCC CCA AGC GTG AGC 294Ala Ser His Met Gly Ala Asp Ile Leu Lys Lys Ala Pro Ser Val Ser
75 80 85TTT GTG TTA GGG GCT AGG AAT GTG TCT AAA ATC TCT CAA GTG ATC CAT 342Phe Val Leu Gly Ala Arg Asn Val Ser Lys Ile Ser Gln Val Ile His
90 95 100AAA GAA AAA GCG GTT GAA GTG GCG ATT GAT TAT GAT GAA AGC GCG TAT 390Lys Glu Lys Ala Val Glu Val Ala Ile Asp Tyr Asp Glu Ser Ala Tyr105 110 115 120GCG TTT GAA TTT TTT GAA AAA AAG GCT CAA ATC CGA TCG TTG CTA AAT 438Ala Phe Glu Phe Phe Glu Lys Lys Ala Gln Ile Arg Ser Leu Leu Asn
125 130 135ATC TCT ATA GGG TGC GAT AAG AAA TGC GCT TAT TGC ATC GTC CCG CAC 486Ile Ser Ile Gly Cys Asp Lys Lys Cys Ala Tyr Cys Ile Val Pro His
140 145 150ACT AGG GGG AAA GAA ATT TCT ATC CCT ATG GAT TTG ATT TTA AAA GAA 534Thr Arg Gly Lys Glu Ile Ser Ile Pro Met Asp Leu Ile Leu Lys Glu
155 160 165GCT GAG AAA TTA GCG AAT AAC GGC ACC AAA GAG CTT ATG CTT TTA GGG 582Ala Glu Lys Leu Ala Asn Asn Gly Thr Lys Glu Leu Met Leu Leu Gly
170 175 180CAG AAT GTG AAT AAT TAC GGC GCG CGT TTC AGC AGCGAG CAT GCG AAA 630Gln Asn Val Asn Asn Tyr Gly Ala Arg Phe Ser Ser Glu His Ala Lys185 190 195 200GTG GAT TTT AGC GAT TTG TTG GAT AAA TTG AGC GAA ATC CAG GGG ATT 678Val Asp Phe Ser Asp Leu Leu Asp Lys Leu Ser Glu Ile Gln Gly Ile
205 210 215GAA AGG ATA CGA TTC ACT TCG CCT CAC CCC TTG CAC ATG AAT GAT GGA 726Glu Arg Ile Arg Phe Thr Ser Pro His Pro Leu His Met Asn Asp Gly
220 225 230TTT TTA GAG CGT TTT GCC AAA AAC CCT AAA GTG TGC AAG AGT ATC CAC 774Phe Leu Glu Arg Phe Ala Lys Asn Pro Lys Val Cys Lys Ser Ile His
235 240 245ATG CCT TTA CAG AGC GGA TCT AGC GCG GTG TTA AAG ATG ATG CGA AGG 822Met Pro Leu Gln Ser Gly Ser Ser Ala Val Leu Lys Met Met Arg Arg
250 255 260GGT TAT AGT AAG GAG TGG TTT TTA AAT AGG GTG GAG AGG TTA AAA GCT 870Gly Tyr Ser Lys Glu Trp Phe Leu Asn Arg Val Glu Arg Leu Lys Ala265 270 275 280TTA GTG CCT GAA GTG GGC ATT AGC ACG GAT ATT ATC GTA GGC TTC CCT 918Leu Val Pro Glu Val Gly Ile Ser Thr Asp Ile Ile Val Gly Phe Pro
285 290 295AAT GAG AGC GAT AAG GAT TTT GAA GAC ACA ATG GAG GTG CTA GAA AAA 966Asn Glu Ser Asp Lys Asp Phe Glu Asp Thr Met Glu Val Leu Glu Lys
300 305 310GTG CGC TTT GAC ACG CTC TAT AGT TTC ATT TAT TCC CCA CGC CCT TTC 1014Val Arg Phe Asp Thr Leu Tyr Ser Phe Ile Tyr Ser Pro Arg Pro Phe
315 320 325ACT GAA GCG GGA GCT TGG AAG GAA AGA GTG CCG TTA GAA GTT TCA TCT 1062
Figure A98808612222701
Leu Ile Leu Ile Asn Thr Cys Ser Val Arg Glu Lys Pro Glu Arg Lys
35 40 45Leu Phe Ser Glu Ile Gly Gln Phe Ala Lys Ile Lys Lys Pro Asn Ala
50 55 60Lys Ile Gly Val Cys Gly Cys Thr Ala Ser His Met Gly Ala Asp Ile65 70 75 80Leu Lys Lys Ala Pro Ser Val Ser Phe Val Leu Gly Ala Arg Asn Val
85 90 95Ser Lys Ile Ser Gln Val Ile His Lys Glu Lys Ala Val Glu Val Ala
100 105 110Ile Asp Tyr Asp Glu Ser Ala Tyr Ala Phe Glu Phe Phe Glu Lys Lys
115 120 125Ala Gln Ile Arg Ser Leu Leu Asn Ile Ser Ile Gly Cys Asp Lys Lys
130 135 140Cys Ala Tyr Cys Ile Val Pro His Thr Arg Gly Lys Glu Ile Ser Ile145 150 155 160Pro Met Asp Leu Ile Leu Lys Glu Ala Glu Lys Leu Ala Asn Asn Gly
165 170 175Thr Lys Glu Leu Met Leu Leu Gly Gln Asn Val Asn Asn Tyr Gly Ala
180 185 190Arg Phe Ser Ser Glu His Ala Lys Val Asp Phe Ser Asp Leu Leu Asp
195 200 205Lys Leu Ser Glu Ile Gln Gly Ile Glu Arg Ile Arg Phe Thr Ser Pro
210 215 220His Pro Leu His Met Asn Asp Gly Phe Leu Glu Arg Phe Ala Lys Asn225 230 235 240Pro Lys Val Cys Lys Ser Ile His Met Pro Leu Gln Ser Gly Ser Ser
245 250255Ala Val Leu Lys Met Met Arg Arg Gly Tyr Ser Lys Glu Trp Phe Leu
260 265 270Asn Arg Val Glu Arg Leu Lys Ala Leu Val Pro Glu Val Gly Ile Ser
275 280 285Thr Asp Ile Ile Val Gly Phe Pro Asn Glu Ser Asp Lys Asp Phe Glu
290 295 300Asp Thr Met Glu Val Leu Glu Lys Val Arg Phe Asp Thr Leu Tyr Ser305 310 315 320Phe Ile Tyr Ser Pro Arg Pro Phe Thr Glu Ala Gly Ala Trp Lys Glu
325 330 335Arg Val Pro Leu Glu Val Ser Ser Ser Arg Leu Glu Arg Leu Gln Asn
340 345 350Arg His Lys Glu Ile Leu Glu Glu Lys Ala Lys Leu Glu Val Gly Lys
355 360 365Thr His Val Val Leu Val Glu Asn Arg Arg Glu Met Asp Asn Gln Ile
370 375 380Val Gly Phe Glu Gly Arg Ser Asp Thr Gly Lys Phe Ile Glu Val Thr385 390 395 400Cys Lys Glu Lys Arg Asn Pro Gly Glu Leu Val Lys Val Glu Ile Ile
405 410 415Ser His Ser Lys Gly Arg Leu Met Ala Ala Thr Lys Gly Asn
420 425 430
(2) Sequence 1251 data:
(i) sequence characteristics:
(A) length: 1530bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 50...1501
(D) Other information:
(xi) Description of the sequence: sequence 1251: ATTGAAATAC AAATACGAAA GCTTAAAAGA GCAAGATTAA AGGCTAGCA ATG GCT AAA 58
Met Ala Lys
1ATC ACA ACC GTG ATT GAT ATA GGC TCT AAT TCA GTG CGT TTG GCT GTC 106Ile Thr Thr Val Ile Asp Ile Gly Ser Asn Ser Val Arg Leu Ala Val
5 10 15TTT AAA AAG ACG AGC CAG TTT GGG TTT TAC TTG CTT TTT GAG ACT AAG 154Phe Lys Lys Thr Ser Gln Phe Gly Phe Tyr Leu Leu Phe Glu Thr Lys20 25 30 35TCT AAG GTT AGG ATT TCA GAG GGC TGT TAT GCG TTT AAT GGA ATC TTG 202Ser Lys Val Arg Ile Ser Glu Gly Cys Tyr Ala Phe Asn Gly Ile Leu
40 45 50CAA GAA ATC CCC ATG CAA CGA GCC GTT AAA GCC TTG AGC GAA TTT AAA 250Gln Glu Ile Pro Met Gln Arg Ala Val Lys Ala Leu Ser Glu Phe Lys
55 60 65GAA ATC GCT CTC AAA TAC AAA AGC AAA AAA ATC CTG TGC GTG GCG ACC 298Glu Ile Ala Leu Lys Tyr Lys Ser Lys Lys Ile Leu Cys Val Ala Thr
70 75 80TCA GCG GTG CGC GAT GCC CCT AAT CGG CTG GAG TTT GTA GCG AGG GTG 346Ser Ala Val Arg Asp Ala Pro Asn Arg Leu Glu Phe Val Ala Arg Val
85 90 95AAA AAG GCT TGC GGT TTG CAA ATC AAA ATC ATT GAT GGG CAA AAA GAA 394Lys Lys AlaCys Gly Leu Gln Ile Lys Ile Ile Asp Gly Gln Lys Glu100 105 110 115GCG CTC TAT GGC GGG ATT GCG TGC GCG AAT TTG TTG CAT AAA AAT TCA 442Ala Leu Tyr Gly Gly Ile Ala Cys Ala Asn Leu Leu His Lys Asn Ser
120 125 130GGG ATC ACG ATA GAT ATT GGA GGG GGT AGC ACC GAG TGC GCG TTG ATT 490Gly Ile Thr Ile Asp Ile Gly Gly Gly Ser Thr Glu Cys Ala Leu Ile
135 140 145GAA AAA GGC AAG ATT AAG GAC TTA ATC TCG CTT GAT GTT GGG ACG ATT 538Glu Lys Gly Lys Ile Lys Asp Leu Ile Ser Leu Asp Val Gly Thr Ile
150 155 160CGC ATT AAA GAA ATG TTT TTA GAC AAA GAC TTA GAG GTC AAA TTG GCT 586Arg Ile Lys Glu Met Phe Leu Asp Lys Asp Leu Glu Val Lys Leu Ala
165 170 175AAA GCC TTT ATC CAA AAA GAA GTC TCT AAA CTG CCC TTT AAA CAC AAA 634Lys Ala Phe Ile Gln Lys Glu Val Ser Lys Leu Pro Phe Lys His Lys180 185 190 195AAC GCC TTT GGG GTG GGG GGG ACG ATC AGA GCG TTG AGT AAG GTA TTG 682Asn Ala Phe Gly Val Gly Gly Thr Ile Arg Ala Leu Ser Lys Val Leu
200 205 210ATG AAA CGC TTT TGT TAC CCT ATT GAT TCT TTG CAT GGC TAT GAA ATA 730Met Lys Arg Phe Cys Tyr Pro Ile Asp Ser Leu His Gly Tyr Glu Ile
215 220 225GAT GCA CAT AAA AAT TTA GCG TTC ATT GAA AAA ATC GTC ATG CTC AAA 778Asp Ala His Lys Asn Leu Ala Phe Ile Glu Lys Ile Val Met Leu Lys
230 235 240GAA GAT CAA TTA CGG CTT TTA GGG GTG AAT GAA GAG CGT TTG GAT AGC 826Glu Asp Gln Leu Arg Leu Leu Gly Val Asn Glu Glu Arg Leu Asp Ser
245 250 255ATC AGG AGC GGG GCG TTG ATT TTA TCA GTC GTT TTG GAG CAT TTA AAA 874Ile Arg Ser Gly Ala Leu Ile Leu Ser Val Val Leu Glu His Leu Lys260 265 270 275ACT TCT TTA ATG ATC ACT AGT GGG GTG GGG GTG AGA GAA GGC GTG TTT 922Thr Ser Leu Met Ile Thr Ser Gly Val Gly Val Arg Glu Gly Val Phe
280 285 290TTG AGC GAT TTA TTG CGC CAT CAT TAC CAT AAA TTC CCC CCC AAT ATC 970Leu Ser Asp Leu Leu Arg His His Tyr His Lys Phe Pro Pro Asn Ile
295 300 305AAC CCC TCT CTC ATC TCT TTA AAA GAT CGC TTT TTG CCC CAT GAA AAG 1018Asn Pro Ser Leu Ile Ser Leu Lys Asp Arg Phe Leu Pro His Glu Lys
310 315 320CAC AGC CAA AAG GTC AAA AAA GAA TGC GTG AAA TTG TTT GAA GCC TTA 1066His Ser Gln Lys Val Lys Lys Glu Cys Val Lys Leu Phe Glu Ala Leu
325 330 335TCG CCT TTG CAT AAA ATA GAT GAA AAA TAC CTT TTC CAT TTA AAG ATT 1114Ser Pro Leu His Lys Ile Asp Glu Lys Tyr Leu Phe His Leu Lys Ile340 345 350 355GCG GGG GAA TTA GCG AGC ATG GGT AAG ATT TTA AGC GTC TAT TTA GCC 1162Ala Gly Glu Leu Ala Ser Met Gly Lys Ile Leu Ser Val Tyr Leu Ala
360 365 370CAC AAG CAC AGC GCG TAT TTT ATT TTA AAC GCT TTG AGT TAT GGC TTT 1210His Lys His Ser Ala Tyr Phe Ile Leu Asn Ala Leu Ser Tyr Gly Phe
375 380 385AGC CAC CAG GAT AGA GCG ATC ATT TGC TTA TTA GCC CAA TTC AGC CAT 1258Ser His Gln Asp Arg Ala Ile Ile Cys Leu Leu Ala Gln Phe Ser His
390 395 400AAA AAA ATC CCT AAA GAC AAC GCT ATC GCC CACATG AGC GCG ATG ATG 1306Lys Lys Ile Pro Lys Asp Asn Ala Ile Ala His Met Ser Ala Met Met
405 410 415CCA AGC CTT TTA ACC TTA CAA TGG CTG AGT TTT ATC CTT TCT TTA GCC 1354Pro Ser Leu Leu Thr Leu Gln Trp Leu Ser Phe Ile Leu Ser Leu Ala420 425 430 435GAA AAT TTG TGC CTA ACA GAC AGC CAT CAT TTA AAA TAC ACG CTA GAA 1402Glu Asn Leu Cys Leu Thr Asp Ser His His Leu Lys Tyr Thr Leu Glu
440 445 450AAA AAC AAG CTT GTG ATC CAT TCT AAT GAC ACG CTT TAC TTG GCT AAA 1450Lys Asn Lys Leu Val Ile His Ser Asn Asp Thr Leu Tyr Leu Ala Lys
455 460 465GAA ATG CTC CCC AAA CTC GTT AAG CCC ATT CCT TTG ACG ATA GAG TTT 1498Glu Met Leu Pro Lys Leu Val Lys Pro Ile Pro Leu Thr Ile Glu Phe
470 475 480GCT TGAAAATAGC GATTGTCAGG CTTTCAGCG 1530Ala
(2) Sequence 1252 data:
(i) sequence characteristics:
(A) length: 484 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1252: met Ala Lys Ile Thr Thr Val Ile Asp Ile Gly Ser Asn Ser Val Arg 151015 Leu Ala Val Phe Lys Lys Thr Ser Gln Phe Gly Phe Tyr Leu Leu Phe
20 25 30Glu Thr Lys Ser Lys Val Arg Ile Ser Glu Gly Cys Tyr Ala Phe Asn
35 40 45Gly Ile Leu Gln Glu Ile Pro Met Gln Arg Ala Val Lys Ala Leu Ser
50 55 60Glu Phe Lys Glu Ile Ala Leu Lys Tyr Lys Ser Lys Lys Ile Leu Cys65 70 75 80Val Ala Thr Ser Ala Val Arg Asp Ala Pro Asn Arg Leu Glu Phe Val
85 90 95Ala Arg Val Lys Lys Ala Cys Gly Leu Gln Ile Lys Ile Ile Asp Gly
100 105 110Gln Lys Glu Ala Leu Tyr Gly Gly Ile Ala Cys Ala Asn Leu Leu His
115 120 125Lys Asn Ser Gly Ile Thr Ile Asp Ile Gly Gly Gly Ser Thr Glu Cys
130 135 140Ala Leu Ile Glu Lys Gly Lys Ile Lys Asp Leu Ile Ser Leu Asp Val145 150 155 160Gly Thr Ile Arg Ile Lys Glu Met Phe Leu Asp Lys Asp Leu Glu Val
165 170 175Lys Leu Ala Lys Ala Phe Ile Gln Lys Glu Val Ser Lys Leu Pro Phe
180 185 190Lys His Lys Asn Ala Phe Gly Val Gly Gly Thr Ile Arg Ala Leu Ser
195 200 205Lys Val Leu Met Lys Arg Phe Cys Tyr Pro Ile Asp Ser Leu His Gly
210 215 220Tyr Glu Ile Asp Ala His Lys Asn Leu Ala Phe Ile Glu Lys Ile Val225 230 235 240Met Leu Lys Glu Asp Gln Leu Arg Leu Leu Gly Val Asn Glu Glu Arg
245 250 255Leu Asp Ser Ile Arg Ser Gly Ala Leu Ile Leu Ser Val Val Leu Glu
260 265270His Leu Lys Thr Ser Leu Met Ile Thr Ser Gly Val Gly Val Arg Glu
275 280 285Gly Val Phe Leu Ser Asp Leu Leu Arg His His Tyr His Lys Phe Pro
290 295 300Pro Asn Ile Asn Pro Ser Leu Ile Ser Leu Lys Asp Arg Phe Leu Pro305 310 315 320His Glu Lys His Ser Gln Lys Val Lys Lys Glu Cys Val Lys Leu Phe
325 330 335Glu Ala Leu Ser Pro Leu His Lys Ile Asp Glu Lys Tyr Leu Phe His
340 345 350Leu Lys Ile Ala Gly Glu Leu Ala Ser Met Gly Lys Ile Leu Ser Val
355 360 365Tyr Leu Ala His Lys His Ser Ala Tyr Phe Ile Leu Asn Ala Leu Ser
370 375 380Tyr Gly Phe Ser His Gln Asp Arg Ala Ile Ile Cys Leu Leu Ala Gln385 390 395 400Phe Ser His Lys Lys Ile Pro Lys Asp Asn Ala Ile Ala His Met Ser
405 410 415Ala Met Met Pro Ser Leu Leu Thr Leu Gln Trp Leu Ser Phe Ile Leu
420 425 430Ser Leu Ala Glu Asn Leu Cys Leu Thr Asp Ser His His Leu Lys Tyr
435 440 445Thr Leu Glu Lys Asn Lys Leu Val Ile His Ser Asn Asp Thr Leu Tyr
450 455 460Leu Ala Lys Glu Met Leu Pro Lys Leu Val Lys Pro Ile Pro Leu Thr465 470 475 480Ile Glu Phe Ala
(2) Sequence 1253 data:
(i) sequence characteristics:
(A) length: 1130bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 60...1073
(D) Other information:
(xi) Description of the sequence: sequence 1253: GCCAACTACC ATAAAAAGGA TTTTTCTATC CAAAATATAG AGCCTAAAAA AATTAAAGA 59ATG CGT TTT AAA CAT CTT AAA GGA AAA AGA ATG ACT TAC AAA GAA CGA 107Met Arg Phe Lys His Leu Lys Gly Lys Arg Met Thr Tyr Lys Glu Arg 151015 CTC ATA CAC GAA AAA ATA TTG AAA CAA GAC GAC AAG GGT TTT AAA ACA 155Leu Ile His Glu Lys Ile Leu Lys Gln Asp Asp Lys Gly Phe Lys Thr
20 25 30GAA CTG CGC ATT TTG AGT ATT TTT ATC GTG GAA TCT TTA GTG AAT ATT 203Glu Leu Arg Ile Leu Ser Ile Phe Ile Val Glu Ser Leu Val Asn Ile
35 40 45TTG GGG TTT ATT TTA GCT AAA ATG CCC CAT TCG TGG TTT TTA AGG TGC 251Leu Gly Phe Ile Leu Ala Lys Met Pro His Ser Trp Phe Leu Arg Cys
50 55 60ATT AAA GCG GTG GCG TGG CTC ATG AAA ACT TTT GAT AAG TGC CGT TAT 299Ile Lys Ala Val Ala Trp Leu Met Lys Thr Phe Asp Lys Cys Arg Tyr 65 70 75 80TTT GAC GCT AAG GCC AAT TTG GAT TTT GTG TTT GGG GAT TCT AAA AGC 347Phe Asp Ala Lys Ala Asn Leu Asp Phe Val Phe Gly Asp Ser Lys Ser
85 90 95GAA GAA GAG AAA AAA AGG ATC ATT AAA AAG GGT TAT GAA AAT TTT GCT395Glu Glu Glu Lys Lys Arg Ile Ile Lys Lys Gly Tyr Glu Asn Phe Ala
100 105 110TTC ATT ATT TTA GAA ACT ATT AGA GTG ATC TTT ATC CCT AAA GAT GAA 443Phe Ile Ile Leu Glu Thr Ile Arg Val Ile Phe Ile Pro Lys Asp Glu
115 120 125TAC GAC GCT CGT TTC ACG CTC ATC AAT GAA GAA AAT GTG TGG AAA TCT 491Tyr Asp Ala Arg Phe Thr Leu Ile Asn Glu Glu Asn Val Trp Lys Ser
130 135 140TTA AAC AAG GAA GGC CAA GCG ATC ACT TTA TGC ATG CAT TTT GGC TAT 539Leu Asn Lys Glu Gly Gln Ala Ile Thr Leu Cys Met His Phe Gly Tyr145 150 155 160TGG GAA GCG GTA GGC ACG ACT TTA GCG CAA TAT TAT GAA AAT TAT GGT 587Trp Glu Ala Val Gly Thr Thr Leu Ala Gln Tyr Tyr Glu Asn Tyr Gly
165 170 175AGG GGG TGT TTG GGG CGT TTG ACT AAA TTT GCC CCT ATC AAT CAC ATG 635Arg Gly Cys Leu Gly Arg Leu Thr Lys Phe Ala Pro Ile Asn His Met
180 185 190ATT ATG AGT AGG CGA GAG GCG TTT GGG GTG CGT TTT GTC AAT AAA ATA 683Ile Met Ser Arg Arg Glu Ala Phe Gly Val Arg Phe Val Asn Lys Ile
195 200 205GGG GCG ATG AAA GAA CTC ATT AAA ATG TAT AAT CAA GGC AAT GGT CTG 731Gly Ala Met Lys Glu Leu Ile Lys Met Tyr Asn Gln Gly Asn Gly Leu
210 215 220GTG GGG ATT TTA GTG GAT CAA AAT GTC GTG CCT AAA GAT GGG GTG GTG 779Val Gly Ile Leu Val Asp Gln Asn Val Val Pro Lys Asp Gly Val Val225 230 235 240GTG AAA TTC TTT GAT AGA GAC GCT ACG CAC ACC ACG ATC GCT TCT ATT 827Val Lys Phe Phe Asp Arg Asp Ala Thr His Thr Thr Ile Ala Ser Ile
245 250 255TTG TCG CGC CGT TAT AAT ATA GAT ATT CAG CCG GTA TTC ATT GAT TTT 875Leu Ser Arg Arg Tyr Asn Ile Asp Ile Gln Pro Val Phe Ile Asp Phe
260 265 270AAT GAC GAT TAT TCG CAT TAT ACA GCG ACC TAT TAT CCG AGT ATC CGC 923Asn Asp Asp Tyr Ser His Tyr Thr Ala Thr Tyr Tyr Pro Ser Ile Arg
275 280 285TCT CAA ATC ACC GAT AAC GCG CAA AAC GAT ATT TTA GAA TGC ACG CAA 97lSer Gln Ile Thr Asp Asn Ala Gln Asn Asp Ile Leu Glu Cys Thr Gln
290 295 300GCC CAA GCG AGT TTG TGC GAA GAG GTG ATT AGA AAC CAC CCG GAA AGT 1019Ala Gln Ala Ser Leu Cys Glu Glu Val Ile Arg Asn His Pro Glu Ser305 310 315 320TAT TTT TGG TTC CAT AGG CGT TTT AAA AGC ACC CAC CCT GAG ATT TAT 1067Tyr Phe Trp Phe His Arg Arg Phe Lys Ser Thr His Pro Glu Ile Tyr
325 330 335CAA AGA TAGGGTTTTG TTTTAATCAA AAATTAAAAA CTAAAGCCTT ATTTTTAAGA AAA 1126Gln ArgCTTT 1130
(2) Sequence 1254 data:
(i) sequence characteristics:
(A) length: 338 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1254: met Arg Phe Lys His Leu Lys Gly Lys Arg Met Thr Tyr Lys Glu Arg 151015 Leu Ile His Glu Lys Ile Leu Lys Gln Asp Asp Lys Gly Phe Lys Thr
20 25 30Glu Leu Arg Ile Leu Ser Ile Phe Ile Val Glu Ser Leu Val Asn Ile
35 40 45Leu Gly Phe Ile Leu Ala Lys Met Pro His Ser Trp Phe Leu Arg Cys
50 55 60Ile Lys Ala Val Ala Trp Leu Met Lys Thr Phe Asp Lys Cys Arg Tyr65 70 75 80Phe Asp Ala Lys Ala Asn Leu Asp Phe Val Phe Gly Asp Ser Lys Ser
85 90 95Glu Glu Glu Lys Lys Arg Ile Ile Lys Lys Gly Tyr Glu Asn Phe Ala
100 105 110Phe Ile Ile Leu Glu Thr Ile Arg Val Ile Phe Ile Pro Lys Asp Glu
115 120 125Tyr Asp Ala Arg Phe Thr Leu Ile Asn Glu Glu Asn Val Trp Lys Ser
130 135 140Leu Asn Lys Glu Gly Gln Ala Ile Thr Leu Cys Met His Phe Gly Tyr145 150 155 160Trp Glu Ala Val Gly Thr Thr Leu Ala Gln Tyr Tyr Glu Asn Tyr Gly
165 170 175Arg Gly Cys Leu Gly Arg Leu Thr Lys Phe Ala Pro Ile Asn His Met
180 185 190Ile Met Ser Arg Arg Glu Ala Phe Gly Val Arg Phe Val Asn Lys Ile
195 200 205Gly Ala Met Lys Glu Leu Ile Lys Met Tyr Asn Gln Gly Asn Gly Leu
210 215 220Val Gly Ile Leu Val Asp Gln Asn Val Val Pro Lys Asp Gly Val Val225 230 235 240Val Lys Phe Phe Asp Arg Asp Ala Thr His Thr Thr Ile Ala Ser Ile
245250 255Leu Ser Arg Arg Tyr Asn Ile Asp Ile Gln Pro Val Phe Ile Asp Phe
260 265 270Asn Asp Asp Tyr Ser His Tyr Thr Ala Thr Tyr Tyr Pro Ser Ile Arg
275 280 285Ser Gln Ile Thr Asp Asn Ala Gln Asn Asp Ile Leu Glu Cys Thr Gln
290 295 300Ala Gln Ala Ser Leu Cys Glu Glu Val Ile Arg Asn His Pro Glu Ser305 310 315 320Tyr Phe Trp Phe His Arg Arg Phe Lys Ser Thr His Pro Glu Ile Tyr
325 330 335Gln Arg
(2) Sequence 1255 data:
(i) sequence characteristics:
(A) length: 8748bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...8694
(D) Other information:
(xi) Description of the sequence: sequence 1255: AGAGGGTAGC ATTTA ATG AAA AAG TTT AAA AAG AAA CCA AAA AGT ATC AAA 51
Met Lys Lys Phe Lys Lys Lys Pro Lys Ser Ile Lys
1 5 10CGA TCG CAT CAA AAT CAA AAA ACA ATC TTA AAG CGT CCT TTA TGG CTT 99Arg Ser His Gln Asn Gln Lys Thr Ile Leu Lys Arg Pro Leu Trp Leu
15 2025ATG CCT TTA CTC ATC AGC GGG TTT GCT AGT GGG GTG TAT GCG AAT AAT 147Met Pro Leu Leu Ile Ser Gly Phe Ala Ser Gly Val Tyr Ala Asn Asn
30 35 40CTG TGG GAT TTG TTA AAC CCA AAA GTG GGG GGT GAG TAT GTG CAT TGG 195Leu Trp Asp Leu Leu Asn Pro Lys Val Gly Gly Glu Tyr Val His Trp45 50 55 60GTT AAG GGC AGT CAG TAT TGT GCA TGG TGG GAA TTT GCT GGG TGT TTA 243Val Lys Gly Ser Gln Tyr Cys Ala Trp Trp Glu Phe Ala Gly Cys Leu
65 70 75AAG AAT GTA TGG GGG GCA AAT CAT AAA GGC TAT GAT GCT GGA AAC GCC 291Lys Asn Val Trp Gly Ala Asn His Lys Gly Tyr Asp Ala Gly Asn Ala
80 85 90GCT AAC TAT TTG TCT TCT CAA AAC TAT CAA GCT ATT TCG GTG GGT AGT 339Ala Asn Tyr Leu Ser Ser Gln Asn Tyr Gln Ala Ile Ser Val Gly Ser
95 100 105GGG AAT GAA ACG GGG ACT TAT AGT TTA AGC GGT TTT ACC AAT TAT GTT 387Gly Asn Glu Thr Gly Thr Tyr Ser Leu Ser Gly Phe Thr Asn Tyr Val
110 115 120GGG GGC AAT CTC ACG ATC AAT CTA GGC AAT AGC GTT GTT TTA GAT TTA 435Gly Gly Asn Leu Thr Ile Asn Leu Gly Asn Ser Val Val Leu Asp Leu125 130 135 140AGC GGT TCT AAT AGT TTC ACT TCG TAT CAA GGT TAT AAT CAA GGC AAA 483Ser Gly Ser Asn Ser Phe Thr Ser Tyr Gln Gly Tyr Asn Gln Gly Lys
145 150 155GAT GAT GTA ACA TTT ACG GTT GGC GCA ATC AAT TTA AAC GGC ACT TTA 531Asp Asp Val Thr Phe Thr Val Gly Ala Ile Asn Leu Asn Gly Thr Leu
160 165 170GAA GTG GGT AAT CGT GTG GGA TCG GGA GCT GGC ACG CAC ACC GGC ACA579Glu Val Gly Asn Arg Val Gly Ser Gly Ala Gly Thr His Thr Gly Thr
175 180 185GCC ACT TTA AAC TTG AAC GCT AAT AAG GTC AAT ATC AAT TCC AAT ATC 627Ala Thr Leu Asn Leu Asn Ala Asn Lys Val Asn Ile Asn Ser Asn Ile
190 195 200AAC GCG TAT AAA ACT TCG CAA GTG AAT ATA GGC AAC GCT AAC AGC GTT 675Asn Ala Tyr Lys Thr Ser Gln Val Asn Ile Gly Asn Ala Asn Ser Val205 210 215 220ATT ACC ATT GGT TCG GTT TCT TTG AGT GGG GAT GTT TGC AGT TCT TTA 723Ile Thr Ile Gly Ser Val Ser Leu Ser Gly Asp Val Cys Ser Ser Leu
225 230 235GCT AGC GTT GGG ATA GGG GCT AAT TGC TCC ACT TCT GGG CCT AGC TAT 771Ala Ser Val Gly Ile Gly Ala Asn Cys Ser Thr Ser Gly Pro Ser Tyr
240 245 250TCT TTT AAA GGG ACG ACT AAC GCT ACT AAC ACG GCG TTT AGT AAT GCA 819Ser Phe Lys Gly Thr Thr Asn Ala Thr Asn Thr Ala Phe Ser Asn Ala
255 260 265AGC GGC AGT TTC ACT TTT GAA GAG AAC GCC ACT TTT AGC GGG GCG AAA 867Ser Gly Ser Phe Thr Phe Glu Glu Asn Ala Thr Phe Ser Gly Ala Lys
270 275 280TGG AAT GGG GGG ACT TAT ACC TTT AAT AAA GAG TTT AGC GCT ACC AAT 915Trp Asn Gly Gly Thr Tyr Thr Phe Asn Lys Glu Phe Ser Ala Thr Asn285 290 295 300AAC ACC GCC TTT AGT AGC GGT AGT TTT AAT TTT AAA GGT GTA AGC TCT 963Asn Thr Ala Phe Ser Ser Gly Ser Phe Asn Phe Lys Gly Val Ser Ser
305 310 315TTT AAT GGT ACT TCG TTT AGT AAC GCT TCT TAT ACT TTT GAC AAT CAA 1011Phe Asn Gly Thr Ser Phe Ser Asn Ala Ser Tyr Thr Phe Asp Asn Gln
320 325 330GCC ACT TTC CAA AAC AGC TCC TTT AAT GGG GGG ACT TTT ACT TTT AAT 1059Ala Thr Phe Gln Asn Ser Ser Phe Asn Gly Gly Thr Phe Thr Phe Asn
335 340 345AAC CAA ACT AAT CCA ACT AAC AAC GCT CAG CAC CCC CAA ATT CAA AAC 1107Asn Gln Thr Asn Pro Thr Asn Asn Ala Gln His Pro Gln Ile Gln Asn
350 355 360AGC TCT TTT AGT GGT AAC GCT ACC ACT CTT AAG GGC TTT GTG AAT TTC 1155Ser Ser Phe Ser Gly Asn Ala Thr Thr Leu Lys Gly Phe Val Asn Phe365 370 375 380CAG CAA GCC TTT AAC AAT TCA AAC CAC CAA CTA ACG ATC CAA AAC GCT 1203Gln Gln Ala Phe Asn Asn Ser Asn His Gln Leu Thr Ile Gln Asn Ala
385 390 395TCC TTT AAT AAC GCC ACT TTT AAC AAT ACC GGT AAA ATC ACT ATA GAA 1251Ser Phe Asn Asn Ala Thr Phe Asn Asn Thr Gly Lys Ile Thr Ile Glu
400 405 410AAA GAT GCG AGT TTT AAT AAC ACG ACA TTC AAC ACT TCT GTT GAT ACA 1299Lys Asp Ala Ser Phe Asn Asn Thr Thr Phe Asn Thr Ser Val Asp Thr
415 420 425AAC AAC ATG AGT GTT ACC GGT GGC GTT ACT TTA AGC GGT AAA AAT GAC 1347Asn Asn Met Ser Val Thr Gly Gly Val Thr Leu Ser Gly Lys Asn Asp
430 435 440TTG AAA AAT GGC TCA ACC CTT GAT TTT GGG AGT TCT AAA ATC ACT CTC 1395Leu Lys Asn Gly Ser Thr Leu Asp Phe Gly Ser Ser Lys Ile Thr Leu445 450 455 460GCT CAA GGG ACG ACT TTC AAC CTC ACA AGT TTA GGC AGT GAG AAG AGC 1443Ala Gln Gly Thr Thr Phe Asn Leu Thr Ser Leu Gly Ser Glu Lys Ser
465 470 475GTA ACGATT TTA AAT TCT AGC GGT GGG ATC ACT TAT AGT AAC CTT TTA 1491Val Thr Ile Leu Asn Ser Ser Gly Gly Ile Thr Tyr Ser Asn Leu Leu
480 485 490AAC CAT GCA ATC AAC GGC TTG ACA AGT GCC TTA AAA ACG AAC GAA AGC 1539Asn His Ala Ile Asn Gly Leu Thr Ser Ala Leu Lys Thr Asn Glu Ser
495 500 505CTT TCA AAT CCG CAA AGT TTC GCT CAA GGT TTG TGG GAT ATA ATC ACT 1587Leu Ser Asn Pro Gln Ser Phe Ala Gln Gly Leu Trp Asp Ile Ile Thr
510 515 520TAC AAT GGG GTT ACC GGG CAG CTT TTG AAT GAA AAC GCT GCA ACA TCT 1635Tyr Asn Gly Val Thr Gly Gln Leu Leu Asn Glu Asn Ala Ala Thr Ser525 530 535 540AAA CCC ACT GAC TCT TCG CCC TCT AAA TCC TCT ACA AAC TCT ACG CAA 1683Lys Pro Thr Asp Ser Ser Pro Ser Lys Ser Ser Thr Asn Ser Thr Gln
545 550 555GTC TAT CAA GTG GGT TAC AAA ATA GGG GAT ACT ATC TAC AAA CTG CAA 1731Val Tyr Gln Val Gly Tyr Lys Ile Gly Asp Thr Ile Tyr Lys Leu Gln
560 565 570GAA ACT TTC AGC CAC AAT TCC ATT ATT ATT CAG GCT TTA GAG AGC GGG 1779Glu Thr Phe Ser His Asn Ser Ile Ile Ile Gln Ala Leu Glu Ser Gly
575 580 585ACT TAC ACG CCA CCC CCT GTC ATT AAC GGC TCC AAA TTT GAC TTA TCC 1827Thr Tyr Thr Pro Pro Pro Val Ile Asn Gly Ser Lys Phe Asp Leu Ser
590 595 600GCT TCA AAT TAT ATC AAT GCT GAC ATG CCT TGG TAT GAC CAT AAA TAT 1875Ala Ser Asn Tyr Ile Asn Ala Asp Met Pro Trp Tyr Asp His Lys Tyr605 610 615 620TAC ATC CCT AAA TCC CAA AAT TTT ACA GAG AGC GGG ACT TAT TAC TTG 1923Tyr Ile Pro Lys Ser GlnAsn Phe Thr Glu Ser Gly Thr Tyr Tyr Leu
625 630 635CCG AGC GTC CAA ATA TGG GGG AGC TAC ACT AAC TCG TTT AAA CAA ACT 1971Pro Ser Val Gln Ile Trp Gly Ser Tyr Thr Asn Ser Phe Lys Gln Thr
640 645 650TTT AGC GCA AAT GGT AGT AAT CTG GTG ATT GGG TAT AAC TCA ACA TGG 2019Phe Ser Ala Asn Gly Ser Asn Leu Val Ile Gly Tyr Asn Ser Thr Trp
655 660 665ACT GAT CAT AAT GTC TCT TCT AGC GGC ACG GTG TCT TTT GGG GAC ACT 2067Thr Asp His Asn Val Ser Ser Ser Gly Thr Val Ser Phe Gly Asp Thr
670 675 680TCA GGG AGC GCT CTT AAT GGG CAT TGC GGA CCT TGG CCG TAT TAC CAA 2115Ser Gly Ser Ala Leu Asn Gly His Cys Gly Pro Trp Pro Tyr Tyr Gln685 690 695 700TGC ACA GGC ACG ACT AAC GGC ACT TAT AGC GCC TAT CAT GTG TAT ATC 2163Cys Thr Gly Thr Thr Asn Gly Thr Tyr Ser Ala Tyr His Val Tyr Ile
705 710 715ACA GCG AAT CTG CGT TCT GGC AAT CGT ATA GGC ACC GGT GGG GCA GCT 2211Thr Ala Asn Leu Arg Ser Gly Asn Arg Ile Gly Thr Gly Gly Ala Ala
720 725 730AAT CTA ATC TTT AAT GGG GTA GAT AGT ATC AAT ATC GCT AAC GCT ACC 2259Asn Leu Ile Phe Asn Gly Val Asp Ser Ile Asn Ile Ala Asn Ala Thr
735 740 745ATC ACG CAA CAT AAC GCC GGA ATC TAT TCA AGC TCT ATG ACT TTT TCC 2307Ile Thr Gln His Asn Ala Gly Ile Tyr Ser Ser Ser Met Thr Phe Ser
750 755 760ACG CAA AGC ATG GAT AAT TCG CAG AAT TTG AAT GGT CTA AAT TCT AAC 2355Thr Gln Ser Met Asp Asn Ser Gln Asn Leu Asn Gly Leu Asn Ser Asn765 770 775780GGC AAA CTT TCG GTG TAT GGC ACC ACT TTC ACT AAC GAA GCT AAA GAT 2403Gly Lys Leu Ser Val Tyr Gly Thr Thr Phe Thr Asn Glu Ala Lys Asp
785 790 795GGG AAA TTC ATT TTC AAT GCA GGG CAA GCG GTT TTT GAA AAC ACC AAC 2451Gly Lys Phe Ile Phe Asn Ala Gly Gln Ala Val Phe Glu Asn Thr Asn
800 805 810TTT AAT GGA GGG AGT TAC CAA TTC AGC GGC GAT AGC TTG AAT TTT TCA 2499Phe Asn Gly Gly Ser Tyr Gln Phe Ser Gly Asp Ser Leu Asn Phe Ser
815 820 825AAC AAC AAC CAG TTC AAT AGC GGT TCG TTT GAA ATT AGC GCA AAA AAC 2547Asn Asn Asn Gln Phe Asn Ser Gly Ser Phe Glu Ile Ser Ala Lys Asn
830 835 840GCT TCG TTC AAT AAC GCT AAC TTT AAC AAC AGC GCT TCT TTT AAT TTC 2595Ala Ser Phe Asn Asn Ala Asn Phe Asn Asn Ser Ala Ser Phe Asn Phe845 850 855 860AAT AAT TCT AAC GCG ACC ACT TCG TTT GTG GGG GAT TTC ACT AAC GCT 2643Asn Asn Ser Asn Ala Thr Thr Ser Phe Val Gly Asp Phe Thr Asn Ala
865 870 875AAT TCA AAT TTG CAA ATC GCC GGG AAC GCT GTT TTT GGG AAC TCT ACT 2691Asn Ser Asn Leu Gln Ile Ala Gly Asn Ala Val Phe Gly Asn Ser Thr
880 885 890AAT GGC TCT CAA AAT ACC GCT AAT TTT AAT AAT ACC GGC TCT GTT AAT 2739Asn Gly Ser Gln Asn Thr Ala Asn Phe Asn Asn Thr Gly Ser Val Asn
895 900 905ATT TCA GGG AAT GCA ACC TTT GAT AAT GTG GTG TTT AAT GGC CCT ACG 2787Ile Ser Gly Asn Ala Thr Phe Asp Asn Val Val Phe Asn Gly Pro Thr
910 915 920AAC ACG AGC GTG AAA GGG CAG GTT ACT TTA AAT AAC ATC ACT TTA AAA 2835Asn Thr Ser Val Lys Gly Gln Val Thr Leu Asn Asn Ile Thr Leu Lys925 930 935 940AAC CTG AAC GCC CCT TTG TCT TTT GGC GAT GGG ACG ATT ACT TTT AAC 2883Asn Leu Asn Ala Pro Leu Ser Phe Gly Asp Gly Thr Ile Thr Phe Asn
945 950 955GCT CAT TCG GTG ATT AAT ATT GCT GAA TCT ATC ACT AAT GGC AAC CCT 2931Ala His Ser Val Ile Asn Ile Ala Glu Ser Ile Thr Asn Gly Asn Pro
960 965 970ATC ACT CTT GTA AGC TCT TCT AAA GAA ATT GAA TAC AAC AAC GCT TTC 2979Ile Thr Leu Val Ser Ser Ser Lys Glu Ile Glu Tyr Asn Asn Ala Phe
975 980 985 AGT AAA AAT CTA TGG CAG CTC ATC AAC TAC CAA GGG CAT GGG GCA AGC 3027 Ser Lys Asn Leu Trp Gln Leu Ile Asn Tyr Gln Gly His Gly Ala Ser
990 995 1000 AGT GAA AAG CTC GTC TCT AGC GCG GGT AAT GGC GTT TAT GAT GTG GTG 3075 Ser Glu Lys Leu Val Ser Ser Ala Gly Asn Gly Val Tyr Asp Val Val1005 1010 1015 1020 TAT TCT TTC AAT AAC CAA ACC TAC AAT TTC CAA GAG GTT TTT TCA CAA 3123 Tyr Ser Phe Asn Asn Gln Thr Tyr Asn Phe Gln Glu Val Phe Ser Gln
1025 1030 1035 AAC AGC ATT TCT ATC CGG CGT TTG GGC GTT AAC ATG GTG TTT GAT TAT 3171 Asn Ser Ile Ser Ile Arg Arg Leu Gly Val Asn Met Val Phe Asp Tyr
1040 1045 1050 GTG GAT ATG GAA AAA TCG GAT CAT TTA TAT TAT CAA AAC GCT CTC GGT 3219 Val Asp Met Glu Lys Ser Asp His Leu Tyr Tyr Gln Asn Ala Leu Gly
1055 1060 1065 TTT ATG ACC TAC ATG CCT AAT AGC TAT AAC AAT AAT TTA GGG AAT GCA 3267 Phe Met Thr Tyr Met ProAsn Ser Tyr Asn Asn Asn Leu Gly Asn Ala
1070 1075 1080 AAC AAC ACC ATT TAC TAT TAC GAC AAG AGC ATT GAT TTT TAT GCG AGC 3315 Asn Asn Thr Ile Tyr Tyr Tyr Asp Lys Ser Ile Asp Phe Tyr Ala Ser1085 1090 1095 1100 GGG AAA ACT CTA TTC ACT AAA GCG GAA TTT TCT CAA ACA TTC ACC GGG 3363 Gly Lys Thr Leu Phe Thr Lys Ala Glu Phe Ser Gln Thr Phe Thr Gly
1105 1110 1115 CAA AAC AGC GCG ATC GTT TTT GGG GCT AAA AGC ATA TGG ACG AGC TTA 3411 Gln Asn Ser Ala Ile Val Phe Gly Ala Lys Ser Ile Trp Thr Ser Leu
1120 1125 1130 AGC GAT GCA CCG CAG TCT AAC ACC ATC ATT CGC TTT GGG GAC AAT AAG 3459 Ser Asp Ala Pro Gln Ser Asn Thr Ile Ile Arg Phe Gly Asp Asn Lys
1135 1140 1145 GGA GCA GGG AGT AAT GAT GCG AGC GGG CAT TGC TGG AAT TTG CAA TGC 3507Gly Ala Gly Ser Asn Asp Ala Ser Gly His Cys Trp Asn Leu Gln Cys
1150 1155 1160 ATA GGC TTT ATT ACA GGG CAT TAT GAA GCG CAA AAG ATT TAC ATC ACC 3555 Ile Gly Phe Ile Thr Gly His Tyr Glu Ala Gln Lys Ile Tyr Ile Thr1165 1170 1175 1180 GGT AGC ATT GAA AGC GGG AAT CGC ATT TCT AGC GGT GGG GGC GCG AGC 3603 Gly Ser Ile Glu Ser Gly Asn Arg Ile Ser Ser Gly Gly Gly Ala Ser
1185 1190 1195 CTT AAT TTT AAC GGG CTT CAA GGC ATT CTT TTA ACG AAC GCG ACT TTG 3651 Leu Asn Phe Asn Gly Leu Gln Gly Ile Leu Leu Thr Asn Ala Thr Leu
1200 1205 1210 TAT AAC CGC GCC GCT GGC ACG CAA AGC TCG TCT ATG AAT TTT ATC TCT 3699 Tyr Asn Arg Ala Ala Gly Thr Gln Ser Ser Ser Met Asn Phe Ile Ser
1215 1220 1225 AAC AGC GCG AAC ATT CAG GCT CAA AAC TCC TAT TTT ATA GAC GAT ACC 3747 Asn Ser Ala Asn Ile Gln Ala Gln Asn Ser Tyr Phe Ile Asp Asp Thr
1230 1235 1240 GCA CAA AAT GGC GGT AAC CCT AAT TTC AGT TTC AAC GCT TTG AAT CTG 3795 Ala Gln Asn Gly Gly Asn Pro Asn Phe Ser Phe Asn Ala Leu Asn Leu1245 1250 1255 1260 GAT TTT TCT AAC AGC TCT TTT AGA GGC TAT GTG GGG AAA ACG CAA TCT 3843 Asp Phe Ser Asn Ser Ser Phe Arg Gly Tyr Val Gly Lys Thr Gln Ser
1265 1270 1275 GTT TTT AAA TTC AAT GCC AAG AAT GCG ATC AGT TTC ACC AAC AGC ACG 3891 Val Phe Lys Phe Asn Ala Lys Asn Ala Ile Ser Phe Thr Asn Ser Thr
1280 1285 1290 AAT TTA AGC TCT GGT TTG TAT CAA ATG CAA GCT AAA AGC GTG TTG TTT 3939 Asn Leu Ser Ser Gly Leu Tyr Gln Met Gln Ala Lys Ser Val Leu Phe
1295 1300 1305 GAC AAT TCC AAT TTA AGC GTT TCA GTG GGG ACA AGC AGT ATT AAA GCC 3987 Asp Asn Ser Asn Leu Ser Val Ser Val Gly Thr Ser Ser Ile Lys Ala
1310 1315 1320 AAT GCG ATC AAT CTT TCT CAA AAT GCC TCT ATT AAT GCG AGC AAC CAT 4035Asn Ala Ile Asn Leu Ser Gln Asn Ala Ser Ile Asn Ala Ser Asn His1325 1330 1335 1340 TCA ACC TTA GAA CTT CAA GGC GAT TTG AAT GTG AAC GAC ACC AGC TCG 4083 Ser Thr Leu Glu Leu Gln Gly Asp Leu Asn Val Asn Asp Thr Ser Ser
1345 1350 1355 CTC AAC CTC AAC CAA AGC ACG ATT AAT GTT TCC AAT AAC GCC ACG ATC 4131 Leu Asn Leu Asn Gln Ser Thr Ile Asn Val Ser Asn Asn Ala Thr Ile
1360 1365 1370 AAC GAT TAT GCG AGC TTG ATT GCG AGT AAT GGC TCT CAC CTT AAT TTT 4179 Asn Asp Tyr Ala Ser Leu Ile Ala Ser Asn Gly Ser His Leu Asn Phe
1375 1380 1385 AAC GGG GCG GTT AAT TTC AAT TCA GCG AAT ATT ACT ACG AGT TTG AAT 4227 Asn Gly Ala Val Asn Phe Asn Ser Ala Asn Ile Thr Thr Ser Leu Asn
1390 1395 1400 AAT TCC TCT ATC GTG TTT AAG GGG GCG GTC TCT TTA GGA GGG CAG TTT 4275 Asn Ser Ser Ile Val Phe Lys Gly Ala Val Ser Leu Gly Gly Gln Phe1405 1410 1415 1420 AAT TTA AGC AAT AAC TCT TCT TTA GAT TTC CAA GGC TCT AGC GCT ATC 4323 Asn Leu Ser Asn Asn Ser Ser Leu Asp Phe Gln Gly Ser Ser Ala Ile
1425 1430 1435 ACC TCT AAC ACG GCG TTT AAT TTC TAT GAT AAC GCT TTT TCT CAA AGC 4371 Thr Ser Asn Thr Ala Phe Asn Phe Tyr Asp Asn Ala Phe Ser Gln Ser
1440 1445 1450 CCC ATC ACT TTC CAT CAA GCC CTT GAC ATT AAA GCG CCC TTA AGT TTG 4419 Pro Ile Thr Phe His Gln Ala Leu Asp Ile Lys Ala Pro Leu Ser Leu
1455 1460 1465 GGA GGC AAC CTT TTA AAC CCT AAC AAC AGC AGC GTG CTG GAT TTA AAA 4467 Gly Gly Asn Leu Leu Asn Pro Asn Asn Ser Ser Val Leu Asp Leu Lys
1470 1475 1480 AAC AGC CAG CTT GTT TTT GGC GAT CAA GGG AGT TTG AAT ATC GCT AAC 4515 Asn Ser Gln Leu Val Phe Gly Asp Gln Gly Ser Leu Asn Ile Ala Asn1485 1490 1495 1500 ATT GAT TTA CTA AGC GAT CTA AAT GAT AAT AAA AAT CGT GTG TAT AAC 4563Ile Asp Leu Leu Ser Asp Leu Asn Asp Asn Lys Asn Arg Val Tyr Asn
1505 1510 1515 ATC ATT CAA GCG GAC ATG AAT AGT AAT TGG TAT GAG CGT ATC AGC TTC 4611 Ile Ile Gln Ala Asp Met Asn Ser Asn Trp Tyr Glu Arg Ile Ser Phe
1520 1525 1530 TTT GGC ATG CAC ATC AAT GAC GGG ATT TAT GAT GCT AAA AAC CAA ACT 4659 Phe Gly Met His Ile Asn Asp Gly Ile Tyr Asp Ala Lys Asn Gln Thr
1535 1540 1545 TAT AGT TTC ACT AAC CCC CTT AAT AAC GCC CTA AAA ATC ACC GAG AGC 4707 Tyr Ser Phe Thr Asn Pro Leu Asn Asn Ala Leu Lys Ile Thr Glu Ser
1550 1555 1560 TTT AAA GAC AAC CAA CTA AGC GTT ACG CTC TCT CAA ATC CCG GGT ATT 4755 Phe Lys Asp Asn Gln Leu Ser Val Thr Leu Ser Gln Ile Pro Gly Ile1565 1570 1575 1580 AAA AAC ACG CTC TAT AAC ATT GGC TCT GAA ATT TTT AAC TAC CAA AAA 4803 Lys Asn Thr Leu Tyr Asn Ile Gly Ser Glu Ile Phe Asn Tyr Gln Lys
1585 1590 1595 GTT TAT AAC AAC GCT AAT GGC GTG TAT TCT TAT AGC GAT GAT GCA CAA 4851 Val Tyr Asn Asn Ala Asn Gly Val Tyr Ser Tyr Ser Asp Asp Ala Gln
1600 1605 1610 GGC GTG TTT TAT CTC ACA AGC AAC GTG AAA GGC TAT TAC AAC CCT AAC 4899 Gly Val Phe Tyr Leu Thr Ser Asn Val Lys Gly Tyr Tyr Asn Pro Asn
1615 1620 1625 CAA TCC TAT CAA GCC AGC GGC AGT AAC AAC ACC ACG AAA AAT AAT AAT 4947 Gln Ser Tyr Gln Ala Ser Gly Ser Asn Asn Thr Thr Lys Asn Asn Asn
1630 1635 1640 CTA ACC TCT GAA TCT TCT ATC ATC TCG CAA ACC TAT AAC GCG CAA GGC 4995 Leu Thr Ser Glu Ser Ser Ile Ile Ser Gln Thr Tyr Asn Ala Gln Gly1645 1650 1655 1660 AAC CCT ATT AGC GCG TTG CAC ATC TAT AAC AAG GGC TAT AAT TTC AAC 5043 Asn Pro Ile Ser Ala Leu His Ile Tyr Asn Lys GlyTyr Asn Phe Asn
1665 1670 1675 AAT ATC AAA GCG TTA GGG CAA ATG GCT CTC AAA CTC TAC CCT GAA ATC 5091Asn Ile Lys Ala Leu Gly Gln Met Ala Leu Lys Leu Tyr Pro Glu Ile
1680 1685 1690 AAA AAG GTA TTA GGG AAT GAT TTT TCG CCC TCA AGT TTG AAC GCT TTA 5139 Lys Lys Val Leu Gly Asn Asp Phe Ser Pro Ser Ser Leu Asn Ala Leu
1695 1700 1705 AAC TCT AAT GCG CTA AAC CAA CTT ACC AAA CTC ATC ACG CCT AAC GAC 5187 Asn Ser Asn Ala Leu Asn Gln Leu Thr Lys Leu Ile Thr Pro Asn Asp
1710 1715 1720 TGG AAA AAC ATT AAC GAG TTG ATT GAT AAC GCA AAC AAT TCG GTG GTG 5235 Trp Lys Asn Ile Asn Glu Leu Ile Asp Asn Ala Asn Asn Ser Val Val1725 1730 1735 1740 CAA AAT TTC AAT AAC GGC ACT TTG ATT GTG GGA GCG ACT CAA ATA GGG 5283 Gln Asn Phe Asn Asn Gly Thr Leu Ile Val Gly Ala Thr Gln Ile Gly
1745 1750 1755 CAA ACA GAC ACC AAT AGC GCG GTT GTT TTT GGG GGC TTG GGC TAT CAA 5331 Gln Thr Asp Thr Asn Ser Ala Val Val Phe Gly Gly Leu Gly Tyr Gln
1760 1765 1770 ACA CCT TGT GAT TAT ACT GAT ATT GTG TGC CAA AAA TTT AGA GGC ACT 5379 Thr Pro Cys Asp Tyr Thr Asp Ile Val Cys Gln Lys Phe Arg Gly Thr
1775 1780 1785 TAT TTA GGA CAG CTT TTA GAG TCC AGC TCG GCT GAT TTG GGC TAT ATT 5427 Tyr Leu Gly Gln Leu Leu Glu Ser Ser Ser Ala Asp Leu Gly Tyr Ile
1790 1795 1800 GAC ACG ACT TTT AAC GCT AAA GAA ATT TAT CTT ACC GGC ACT TTA GGG 5475 Asp Thr Thr Phe Asn Ala Lys Glu Ile Tyr Leu Thr Gly Thr Leu Gly18051810 1815 1820 AGC GGG AAC GCA TGG GGG ACT GGG GGG AGC GCG AGC GTA ACT TTT AAC 5523 Ser Gly Asn Ala Trp Gly Thr Gly Gly Ser Ala Ser Val Thr Phe Asn
1825 1830 1835 AGC CAA ACT TCG CTC ATT CTC AAT CAG GCT AAT ATC GTA AGC TCG CAA 5571 Ser Gln Thr Ser Leu Ile Leu Asn Gln Ala Asn Ile Val Ser Ser Gln
1840 1845 1850 ACC GAT GGG ATC TTT AGC ATG CTG GGT CAA GAG GGT ATT AAT AAG GTT 5619Thr Asp Gly Ile Phe Ser Met Leu Gly Gln Glu Gly Ile Asn Lys Val
1855 1860 1865 TTC AAT CAA GCC GGG CTC GCT AAT ATT TTG GGC GAA GTG GCG GTG CAA 5667 Phe Asn Gln Ala Gly Leu Ala Asn Ile Leu Gly Glu Val Ala Val Gln
1870 1875 1880 TCC ATC AAC AAA GCC GGG GGA TTA GGG AAT TTG ATA GTA AAT ACG CTA 5715 Ser Ile Asn Lys Ala Gly Gly Leu Gly Asn Leu Ile Val Asn Thr Leu1885 1890 1895 1900 GGG AGT AAT AGC GTG ATT GGG GGG TAT TTA ACG CCT GAA CAA AAA AAT 5763 Gly Ser Asn Ser Val Ile Gly Gly Tyr Leu Thr Pro Glu Gln Lys Asn
1905 1910 1915 CAA ACC CTA AGC CAG CTT TTA GGG CAG AAT AAC TTT GAT AAT CTC ATG 5811 Gln Thr Leu Ser Gln Leu Leu Gly Gln Asn Asn Phe Asp Asn Leu Met
1920 1925 1930 AAC GAT AGC GGT TTG AAT ACG GCG ATT AAG GAT TTG ATC AGA CAA AAA 5859 Asn Asp Ser Gly Leu Asn Thr Ala Ile Lys Asp Leu Ile Arg Gln Lys
1935 1940 1945 TTA GGC TTT TGG ACC GGG CTA GTG GGG GGA TTA GCC GGA CTA GGG GGC 5907 Leu Gly Phe Trp Thr Gly Leu Val Gly Gly Leu Ala Gly Leu Gly Gly
1950 19551960 ATT GAT TTG CAA AAC CCT GAA AAG CTT ATA GGC AGC ATG TCA ATC AAT 5955 Ile Asp Leu Gln Asn Pro Glu Lys Leu Ile Gly Ser Met Ser Ile Asn1965 1970 1975 1980 GAT TTA TTG AGT AAA AAA GGG TTG TTC AAT CAG ATC ACC GGC TTT ATT 6003 Asp Leu Leu Ser Lys Lys Gly Leu Phe Asn Gln Ile Thr Gly Phe Ile
1985 1990 1995 TCC GCT AAC GAT ATA GGG CAA GTC ATA AGC GTA ATG TTG CAA GAT ATT 6051 Ser Ala Asn Asp Ile Gly Gln Val Ile Ser Val Met Leu Gln Asp Ile
2000 2005 2010 GTC AAA CCG AGC AAC GCT TTA AAA AAC GAT GTA GCG GCT TTA GGC AAG 6099 Val Lys Pro Ser Asn Ala Leu Lys Asn Asp Val Ala Ala Leu Gly Lys
2015 2020 2025 CAA ATG ATT GGC GAA TTT TTA GGC CAA GAC ACG CTC AAT TCT TTA GAA 6147Gln Met Ile Gly Glu Phe Leu Gly Gln Asp Thr Leu Asn Ser Leu Glu
2030 2035 2040 AGC TTG TTG CAA AAC CAG CAG ATT AAA AGC GTT TTA GAC AAA GTC CTA 6195 Ser Leu Leu Gln Asn Gln Gln Ile Lys Ser Val Leu Asp Lys Val Leu2045 2050 2055 2060 GCG GCT AAA GGT TTA GGG CCT ATT TAT GAA CAA GGC TTG GGG GAT TTG 6243 Ala Ala Lys Gly Leu Gly Pro Ile Tyr Glu Gln Gly Leu Gly Asp Leu
2065 2070 2075 ATA CCT AAT CTT GGT AAA AAA GGG CTT TTC GCT CCT TAT GGC TTG AGT 6291 Ile Pro Asn Leu Gly Lys Lys Gly Leu Phe Ala Pro Tyr Gly Leu Ser
2080 2085 2090 CAA GTG TGG CAA AAA GGG GAT TTT AGT TTC AAC GCA CAA GGC AAT GTT 6339 Gln Val Trp Gln Lys Gly Asp Phe Ser Phe Asn Ala Gln Gly Asn Val
2095 2100 2105 TTT GTG CAA AAT TCC ACT TTC TCTAAC GCC AAT GGA GGC ACG CTC TCT 6387 Phe Val Gln Asn Ser Thr Phe Ser Asn Ala Asn Gly Gly Thr Leu Ser
2110 2115 2120 TTT AAC GCA GGA AAT TCG CTC ATT TTT GCC GGA AAC AAT CAT ATT GCA 6435 Phe Asn Ala Gly Asn Ser Leu Ile Phe Ala Gly Asn Asn His Ile Ala2125 2130 2135 2140 TTC ACT AAC CAC GCT GGA ACT CTT CAA TTA TTG TCC GAT CAA GTT TCT 6483 Phe Thr Asn His Ala Gly Thr Leu Gln Leu Leu Ser Asp Gln Val Ser
2145 2150 2155 AAC ATT AAC ATC ACC ACG CTT AAC GCT AGC AAC GGC CTT AAG ATT AAC 6531 Asn Ile Asn Ile Thr Thr Leu Asn Ala Ser Asn Gly Leu Lys Ile Asn
2160 2165 2170 GCC GCT AAT AAC AAT GTT TCT GTG TCT CAA GGC AAT CTG TTT GTC AGC 6579 Ala Ala Asn Asn Asn Val Ser Val Ser Gln Gly Asn Leu Phe Val Ser
2175 2180 2185 GCT AGC TGC GCG CAA CAA AGC GAT CCA ACT ACA GCT AAT ATT GCA AAC 6627 Ala Ser Cys Ala Gln Gln Ser Asp Pro Thr Thr Ala Asn Ile Ala Asn
2190 2195 2200 CCT TGC GCG CTT AGC GCC CAA AGC ACG AAT GGC GCT TCT TCT AAT AAT 6675Pro Cys Ala Leu Ser Ala Gln Ser Thr Asn Gly Ala Ser Ser Asn Asn2205 2210 2215 2220 GCG TCA AAT AAC GCG CCA ATC GCC TTG AGT AAT AAC GAT GAA AGC TTG 6723 Ala Ser Asn Asn Ala Pro Ile Ala Leu Ser Asn Asn Asp Glu Ser Leu
2225 2230 2235 ATG GTT GCG GCG AAT GAT TTC AAT TTT TCA GGC AAT ATT TAC GCT AAT 6771 Met Val Ala Ala Asn Asp Phe Asn Phe Ser Gly Asn Ile Tyr Ala Asn
2240 2245 2250 GGG GTG GTT GAT TTT TCA AAG ATT AAA GGC TCT GCA AAC ATT AAA AAC 6819 Gly Val ValAsp Phe Ser Lys Ile Lys Gly Ser Ala Asn Ile Lys Asn
2255 2260 2265 CTG TAT CTT TAC AAT AAC GCT CAA TTC CAA GCC AAC AAT CTC ACT ATT 6867 Leu Tyr Leu Tyr Asn Asn Ala Gln Phe Gln Ala Asn Asn Leu Thr Ile
2270 2275 2280 TCC AAT CAA GCG GTG TTA GAA AAA AAC GCC AGC TTT GTA ACG AAT AAT 6915 Ser Asn Gln Ala Val Leu Glu Lys Asn Ala Ser Phe Val Thr Asn Asn2285 2290 2295 2300 TTA AAC ATT CAA GGA GCG TTT AAC AAC AAC GCC ACG CAA AAA ATA GAG 6963 Leu Asn Ile Gln Gly Ala Phe Asn Asn Asn Ala Thr Gln Lys Ile Glu
2305 2310 2315 GTG CTT CAA AAT TTA GTG ATC GCT TCA AAC GCT TCT TTA AGC ACC GGG 7011 Val Leu Gln Asn Leu Val Ile Ala Ser Asn Ala Ser Leu Ser Thr Gly
2320 2325 2330 ATT TAT GGG TTA GAA GTA GGG GGG GCT TTG AAT AAT TCT GGA GCG ATC 7059 Ile Tyr Gly Leu Glu Val Gly Gly Ala Leu Asn Asn Ser Gly Ala Ile
2335 2340 2345 CAT TTT AAT TTA GAA AAT ACC CAA ACG CCA ACG CCG CTC ATT CAA GCA 7107 His Phe Asn Leu Glu Asn Thr Gln Thr Pro Thr Pro Leu Ile Gln Ala
2350 2355 2360 GAG GGG ATC ATT AAC CTC AAC ACC ACC CAA ACG CCT TTT ATG AAT GTC 7155 Glu Gly Ile Ile Asn Leu Asn Thr Thr Gln Thr Pro Phe Met Asn Val2365 2370 2375 2380 AAT AAC AGC ATG GCC AAT AAT ACG ACT TAC ACT TTA TTA AAA AGC AGC 7203Asn Asn Ser Met Ala Asn Asn Thr Thr Tyr Thr Leu Leu Lys Ser Ser
2385 2390 2395 CGT TAC ATT GAT TAC AAT ATC AAC CCC AAC AGC TTG CAA TCG TAT TTG 7251 Arg Tyr Ile Asp Tyr Asn Ile Asn Pro Asn Ser Leu Gln Ser Tyr Leu
2400 2405 2410 AAT CTC TAC ACT TTA ATC AAT ATC AAC GGG AAC CAC ATA GAG GAA AAA 7299 Asn Leu Tyr Thr Leu Ile Asn Ile Asn Gly Asn His Ile Glu Glu Lys
2415 2420 2425 AAC GGC GCA TTG ACT TAT TTG GGC CAA CGG GTT TTG TTG CAA GAT AAG 7347 Asn Gly Ala Leu Thr Tyr Leu Gly Gln Arg Val Leu Leu Gln Asp Lys
2430 2435 2440 GGG TTA TTG TTA AGC GTA GCG CTG CCC AAC TCA AAC AAC GCT TCT CAA 7395 Gly Leu Leu Leu Ser Val Ala Leu Pro Asn Ser Asn Asn Ala Ser Gln2445 2450 2455 2460 AAC AAC ATT TTA AGC CTT TCT GTC CTT TAT AAC CAA GTT AAA ATG TCT 7443 Asn Asn Ile Leu Ser Leu Ser Val Leu Tyr Asn Gln Val Lys Met Ser
2465 2470 2475 TGC GGC GAT AAA GCG ATG GAT TTT ACC CCC CCT ACC TTA CAA GAT TAC 7491 Cys Gly Asp Lys Ala Met Asp Phe Thr Pro Pro Thr Leu Gln Asp Tyr
2480 2485 2490 ATT GTG GGC ATT CAA GGG CAA AGC GCG CTC AAT CAA ATT GAA GCT GTT 7539 Ile Val Gly Ile Gln Gly Gln Ser Ala Leu Asn Gln Ile Glu Ala Val
2495 2500 2505 GGG GGG AAC GCT ATC AAG TGG CTT TCA ACA TTG ATG ATG GAG ACT AAA 7587 Gly Gly Asn Ala Ile Lys Trp Leu Ser Thr Leu Met Met Glu Thr Lys
2510 2515 2520 GAA AAC CCG TTT TTT GCG CCG ATT TAT TTA AAA AAC CAC TCT TTG AAT 7635 Glu Asn Pro Phe Phe Ala Pro Ile Tyr Leu Lys Asn His Ser Leu Asn2525 2530 2535 2540 GAA ATC TTA GGC GTA ACA AAA GAT CTT CAA AAC ACC GCA AGC TTG ATT 7683 Glu Ile Leu Gly Val Thr Lys Asp Leu Gln Asn Thr Ala Ser Leu Ile
2545 25502555 TCT AAC CCT AAT TTT AGA GAT AAC GCT ACC AAT CTT TTA GAA TTG GCG 7731Ser Asn Pro Asn Phe Arg Asp Asn Ala Thr Asn Leu Leu Glu Leu Ala
2560 2565 2570 AGT TAC ACC CAA CAA ACC AGC CGT TTA ACA AAA CTC TCT GAT TTT AGA 7779 Ser Tyr Thr Gln Gln Thr Ser Arg Leu Thr Lys Leu Ser Asp Phe Arg
2575 2580 2585 TCT AGA GAG GGA GAG TCT GAT TTT TCT TTG TTA GAG CTT AAA AAC AAG 7827 Ser Arg Glu Gly Glu Ser Asp Phe Ser Leu Leu Glu Leu Lys Asn Lys
2590 2595 2600 CGT TTT AGC GAT CCT AAT CCA GAG GTT TTT GTC AAA TAC TCT CAA CTT 7875 Arg Phe Ser Asp Pro Asn Pro Glu Val Phe Val Lys Tyr Ser Gln Leu2605 2610 2615 2620 AGC AAA CAC CCA AAT AAC CTT TGG GTT CAA GGG GTG GGA GGA GCG AGC 7923 Ser Lys His Pro Asn Asn Leu Trp Val Gln Gly Val Gly Gly Ala Ser
2625 2630 2635 TTT ATT TCT GGG GGC AAT GGC ACG CTT TAT GGC TTG AAT GCG GGC TAT 7971 Phe Ile Ser Gly Gly Asn Gly Thr Leu Tyr Gly Leu Asn Ala Gly Tyr
2640 2645 2650 GAC AGG TTG GTT AAA AAT GTG ATC CTT GGG GGT TAT GTG GCT TAT GGC 8019 Asp Arg Leu Val Lys Asn Val Ile Leu Gly Gly Tyr Val Ala Tyr Gly
2655 2660 2665 TAT AGC GAC TTT AAT GGG AAC ATC ATG CAT TCT TTG GGT AAT AAT GTG 8067 Tyr Ser Asp Phe Asn Gly Asn Ile Met His Ser Leu Gly Asn Asn Val
2670 2675 2680 GAT GTG GGG ATG TAT GCG AGG GCT TTT TTA AAA AGG AAC GAA TTC ACT 8115 Asp Val Gly Met Tyr Ala Arg Ala Phe Leu Lys Arg Asn Glu Phe Thr2685 2690 2695 2700 TTG AGC GCG AAT GAA ACT TAT GGA GGC AAT GCA ACT AGT ATCAAT TCT 8163 Leu Ser Ala Asn Glu Thr Tyr Gly Gly Asn Ala Thr Ser Ile Asn Ser
2705 2710 2715 TCT AAT TCT TTG CTC TCT GTG TTG AAC CAA CGC TAC AAC TAC AAC ACC 8211 Ser Asn Ser Leu Leu Ser Val Leu Asn Gln Arg Tyr Asn Tyr Asn Thr
2720 2725 2730 TGG ACA ACG AGC GTG AAC GGG AAT TAC GGC TAT GAT TTC ATG TTC AAA 8259Trp Thr Thr Ser Val Asn Gly Asn Tyr Gly Tyr Asp Phe Met Phe Lys
2735 2740 2745 CAA AAA AGC GTG GTG CTA AAA CCT CAA GTG GGT TTG AGC TAT CAT TTC 8307 Gln Lys Ser Val Val Leu Lys Pro Gln Val Gly Leu Ser Tyr His Phe
2750 2755 2760 ATA GGT CTA AGT GGG ATG AAA GGC AAT GAT GCC GCT TAC AAA CAA TTC 8355 Ile Gly Leu Ser Gly Met Lys Gly Asn Asp Ala Ala Tyr Lys Gln Phe2765 2770 2775 2780 CTC ATG CAT TCA AAC CCC TCT AAC GAA TCG GTT TTA ACG CTC AAC ATG 8403 Leu Met His Ser Asn Pro Ser Asn Glu Ser Val Leu Thr Leu Asn Met
2785 2790 2795 GGG TTG GAG AGC CGT AAA TAT TTT GGT AAA AAT TCC TAT TAT TTT GTA 8451 Gly Leu Glu Ser Arg Lys Tyr Phe Gly Lys Asn Ser Tyr Tyr Phe Val
2800 2805 2810 ACG GCG AGA CTA GGT AGG GAT CTT TTG ATC AAA TCT AAA GGC AGC AAT 8499 Thr Ala Arg Leu Gly Arg Asp Leu Leu Ile Lys Ser Lys Gly Ser Asn
2815 2820 2825 ACG GTG CGT TTT GTG GGC GAA AAC ACT TTA TTG TAT CGC AAG GGG GAA 8547 Thr Val Arg Phe Val Gly Glu Asn Thr Leu Leu Tyr Arg Lys Gly Glu
2830 2835 2840 GTT TTT AAC ACT TTT GCG AGC GTG ATT ACA GGG GGC GAA ATG CAT TTG 8595 Val Phe Asn Thr Phe Ala Ser Val Ile Thr Gly Gly Glu Met His Leu2845 2850 2855 2860 TGG CGT TTG GTG TAT GTG AAT GCG GGG GTG GGG CTT AAG ATG GGC TTG 8643 Trp Arg Leu Val Tyr Val Asn Ala Gly Val Gly Leu Lys Met Gly Leu
2865 2870 2875 CAA TAC CAA GAT ATT AAT ATA ACC GGG AAT GTG GGC ATG CGA GTG GCG 8691 Gln Tyr Gln Asp Ile Asn Ile Thr Gly Asn Val Gly Met Arg Val Ala
2880 2885 2890 TTT TAGCTTTTTT GCTATAATGC TTCGTTCAAA TTTTATGGTT AGGTTTTTCT ATGT 8748 Phe
(2) Sequence 1256 data:
(i) sequence characteristics:
(A) length: 2893 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1256: met Lys Lys Phe Lys Lys Lys Pro Lys Ser Ile Lys Arg Ser His Gln 151015 Asn Gln Lys Thr Ile Leu Lys Arg Pro Leu Trp Leu Met Pro Leu Leu
20 25 30Ile Ser Gly Phe Ala Ser Gly Val Tyr Ala Asn Asn Leu Trp Asp Leu
35 40 45Leu Asn Pro Lys Val Gly Gly Glu Tyr Val His Trp Val Lys Gly Ser
50 55 60Gln Tyr Cys Ala Trp Trp Glu Phe Ala Gly Cys Leu Lys Asn Val Trp65 70 75 80Gly Ala Asn His Lys Gly Tyr Asp Ala Gly Asn Ala Ala Asn Tyr Leu
85 90 95Ser Ser Gln Asn Tyr Gln Ala IleSer Val Gly Ser Gly Asn Glu Thr
100 105 110Gly Thr Tyr Ser Leu Ser Gly Phe Thr Asn Tyr Val Gly Gly Asn Leu
115 120 125Thr Ile Asn Leu Gly Asn Ser Val Val Leu Asp Leu Ser Gly Ser Asn
130 135 140Ser Phe Thr Ser Tyr Gln Gly Tyr Asn Gln Gly Lys Asp Asp Val Thr145 150 155 160Phe Thr Val Gly Ala Ile Asn Leu Asn Gly Thr Leu Glu Val Gly Asn
165 170 175Arg Val Gly Ser Gly Ala Gly Thr His Thr Gly Thr Ala Thr Leu Asn
180 185 190Leu Asn Ala Asn Lys Val Asn Ile Asn Ser Asn Ile Asn Ala Tyr Lys
195 200 205Thr Ser Gln Val Asn Ile Gly Asn Ala Asn Ser Val Ile Thr Ile Gly
210 215 220Ser Val Ser Leu Ser Gly Asp Val Cys Ser Ser Leu Ala Ser Val Gly225 230 235 240Ile Gly Ala Asn Cys Ser Thr Ser Gly Pro Ser Tyr Ser Phe Lys Gly
245 250 255Thr Thr Asn Ala Thr Asn Thr Ala Phe Ser Asn Ala Ser Gly Ser Phe
260 265 270Thr Phe Glu Glu Asn Ala Thr Phe Ser Gly Ala Lys Trp Asn Gly Gly
275 280 285Thr Tyr Thr Phe Asn Lys Glu Phe Ser Ala Thr Asn Asn Thr Ala Phe
290 295 300Ser Ser Gly Ser Phe Asn Phe Lys Gly Val Ser Ser Phe Asn Gly Thr305 310 315 320Ser Phe Ser Asn Ala Ser Tyr ThrPhe Asp Asn Gln Ala Thr Phe Gln
325 330 335Asn Ser Ser Phe Asn Gly Gly Thr Phe Thr Phe Asn Asn Gln Thr Asn
340 345 350Pro Thr Asn Asn Ala Gln His Pro Gln Ile Gln Asn Ser Ser Phe Ser
355 360 365Gly Asn Ala Thr Thr Leu Lys Gly Phe Val Asn Phe Gln Gln Ala Phe
370 375 380Asn Asn Ser Asn His Gln Leu Thr Ile Gln Asn Ala Ser Phe Asn Asn385 390 395 400Ala Thr Phe Asn Asn Thr Gly Lys Ile Thr Ile Glu Lys Asp Ala Ser
405 410 415Phe Asn Asn Thr Thr Phe Asn Thr Ser Val Asp Thr Asn Asn Met Ser
420 425 430Val Thr Gly Gly Val Thr Leu Ser Gly Lys Asn Asp Leu Lys Asn Gly
435 440 445Ser Thr Leu Asp Phe Gly Ser Ser Lys Ile Thr Leu Ala Gln Gly Thr
450 455 460Thr Phe Asn Leu Thr Ser Leu Gly Ser Glu Lys Ser Val Thr Ile Leu465 470 475 480Asn Ser Ser Gly Gly Ile Thr Tyr Ser Asn Leu Leu Asn His Ala Ile
485 490 495Asn Gly Leu Thr Ser Ala Leu Lys Thr Asn Glu Ser Leu Ser Asn Pro
500 505 510Gln Ser Phe Ala Gln Gly Leu Trp Asp Ile Ile Thr Tyr Asn Gly Val
515 520 525Thr Gly Gln Leu Leu Asn Glu Asn Ala Ala Thr Ser Lys Pro Thr Asp
530 535 540Ser Ser Pro Ser Lys Ser SerThr Asn Ser Thr Gln Val Tyr Gln Val545 550 555 560Gly Tyr Lys Ile Gly Asp Thr Ile Tyr Lys Leu Gln Glu Thr Phe Ser
565 570 575His Asn Ser Ile Ile Ile Gln Ala Leu Glu Ser Gly Thr Tyr Thr Pro
580 585 590Pro Pro Val Ile Asn Gly Ser Lys Phe Asp Leu Ser Ala Ser Asn Tyr
595 600 605Ile Asn Ala Asp Met Pro Trp Tyr Asp His Lys Tyr Tyr Ile Pro Lys
610 615 620Ser Gln Asn Phe Thr Glu Ser Gly Thr Tyr Tyr Leu Pro Ser Val Gln625 630 635 640Ile Trp Gly Ser Tyr Thr Asn Ser Phe Lys Gln Thr Phe Ser Ala Asn
645 650 655Gly Ser Asn Leu Val Ile Gly Tyr Asn Ser Thr Trp Thr Asp His Asn
660 665 670Val Ser Ser Ser Gly Thr Val Ser Phe Gly Asp Thr Ser Gly Ser Ala
675 680 685Leu Asn Gly His Cys Gly Pro Trp Pro Tyr Tyr Gln Cys Thr Gly Thr
690 695 700Thr Asn Gly Thr Tyr Ser Ala Tyr His Val Tyr Ile Thr Ala Asn Leu705 710 715 720Arg Ser Gly Asn Arg Ile Gly Thr Gly Gly Ala Ala Asn Leu Ile Phe
725 730 735Asn Gly Val Asp Ser Ile Asn Ile Ala Asn Ala Thr Ile Thr Gln His
740 745 750Asn Ala Gly Ile Tyr Ser Ser Ser Met Thr Phe Ser Thr Gln Ser Met
755 760 765Asp Asn Ser GlnAsn Leu Asn Gly Leu Asn Ser Asn Gly Lys Leu Ser
770 775 780Val Tyr Gly Thr Thr Phe Thr Asn Glu Ala Lys Asp Gly Lys Phe Ile785 790 795 800Phe Asn Ala Gly Gln Ala Val Phe Glu Asn Thr Asn Phe Asn Gly Gly
805 810 815Ser Tyr Gln Phe Ser Gly Asp Ser Leu Asn Phe Ser Asn Asn Asn Gln
820 825 830Phe Asn Ser Gly Ser Phe Glu Ile Ser Ala Lys Asn Ala Ser Phe Asn
835 840 845Asn Ala Asn Phe Asn Asn Ser Ala Ser Phe Asn Phe Asn Asn Ser Asn
850 855 860Ala Thr Thr Ser Phe Val Gly Asp Phe Thr Asn Ala Asn Ser Asn Leu865 870 875 880Gln Ile Ala Gly Asn Ala Val Phe Gly Asn Ser Thr Asn Gly Ser Gln
885 890 895Asn Thr Ala Asn Phe Asn Asn Thr Gly Ser Val Asn Ile Ser Gly Asn
900 905 910Ala Thr Phe Asp Asn Val Val Phe Asn Gly Pro Thr Asn Thr Ser Val
915 920 925Lys Gly Gln Val Thr Leu Asn Asn Ile Thr Leu Lys Asn Leu Asn Ala
930 935 940Pro Leu Ser Phe Gly Asp Gly Thr Ile Thr Phe Asn Ala His Ser Val945 950 955 960Ile Asn Ile Ala Glu Ser Ile Thr Asn Gly Asn Pro Ile Thr Leu Val
965 970 975Ser Ser Ser Lys Glu Ile Glu Tyr Asn Asn Ala Phe Ser Lys Asn Leu
980 985 990TrpGln Leu Ile Asn Tyr Gln Gly His Gly Ala Ser Ser Glu Lys Leu
995 1000 1005Val Ser Ser Ala Gly Asn Gly Val Tyr Asp Val Val Tyr Ser Phe Asn 1010 1015 1020Asn Gln Thr Tyr Asn Phe Gln Glu Val Phe Ser Gln Asn Ser Ile Ser025 1030 1035 1040Ile Arg Arg Leu Gly Val Asn Met Val Phe Asp Tyr Val Asp Met Glu
1045 1050 1055Lys Ser Asp His Leu Tyr Tyr Gln Asn Ala Leu Gly Phe Met Thr Tyr
1060 1065 1070Met Pro Asn Ser Tyr Asn Asn Asn Leu Gly Asn Ala Asn Asn Thr Ile
1075 1080 1085Tyr Tyr Tyr Asp Lys Ser Ile Asp Phe Tyr Ala Ser Gly Lys Thr Leu 1090 1095 1100Phe Thr Lys Ala Glu Phe Ser Gln Thr Phe Thr Gly Gln Asn Ser Ala105 1110 1115 1120Ile Val Phe Gly Ala Lys Ser Ile Trp Thr Ser Leu Ser Asp Ala Pro
1125 1130 1135Gln Ser Asn Thr Ile Ile Arg Phe Gly Asp Asn Lys Gly Ala Gly Ser
1140 1145 1150Asn Asp Ala Ser Gly His Cys Trp Asn Leu Gln Cys Ile Gly Phe Ile
1155 1160 1165Thr Gly His Tyr Glu Ala Gln Lys Ile Tyr Ile Thr Gly Ser Ile Glu 1170 1175 1180Ser Gly Asn Arg Ile Ser Ser Gly Gly Gly Ala Ser Leu Asn Phe Asn185 1190 1195 1200Gly Leu Gln Gly Ile Leu Leu Thr Asn Ala Thr Leu Tyr Asn Arg Ala
1205 1210 1215Ala Gly Thr Gln Ser Ser Ser Met Asn Phe Ile Ser Asn Ser Ala Asn
1220 1225 1230Ile Gln Ala Gln Asn Ser Tyr Phe Ile Asp Asp Thr Ala Gln Asn Gly
1235 1240 1245Gly Asn Pro Asn Phe Ser Phe Asn Ala Leu Asn Leu Asp Phe Ser Asn 1250 1255 1260Ser Ser Phe Arg Gly Tyr Val Gly Lys Thr Gln Ser Val Phe Lys Phe265 1270 1275 1280Asn Ala Lys Asn Ala Ile Ser Phe Thr Asn Ser Thr Asn Leu Ser Ser
1285 1290 1295Gly Leu Tyr Gln Met Gln Ala Lys Ser Val Leu Phe Asp Asn Ser Asn
1300 1305 1310Leu Ser Val Ser Val Gly Thr Ser Ser Ile Lys Ala Asn Ala Ile Asn
1315 1320 1325Leu Ser Gln Asn Ala Ser Ile Asn Ala Ser Asn His Ser Thr Leu Glu 1330 1335 1340Leu Gln Gly Asp Leu Asn Val Asn Asp Thr Ser Ser Leu Asn Leu Asn345 1350 1355 1360Gln Ser Thr Ile Asn Val Ser Asn Asn Ala Thr Ile Asn Asp Tyr Ala
1365 1370 1375Ser Leu Ile Ala Ser Asn Gly Ser His Leu Asn Phe Asn Gly Ala Val
1380 1385 1390Asn Phe Asn Ser Ala Asn Ile Thr Thr Ser Leu Asn Asn Ser Ser Ile
1395 1400 1405Val Phe Lys Gly Ala Val Ser Leu Gly Gly Gln Phe Asn Leu Ser Asn 1410 1415 1420Asn Ser Ser Leu Asp Phe Gln Gly Ser Ser Ala Ile Thr Ser Asn Thr425 1430 1435 1440Ala Phe Asn Phe Tyr Asp Asn Ala Phe Ser Gln Ser Pro Ile Thr Phe
1445 1450 1455His Gln Ala Leu Asp Ile Lys Ala Pro Leu Ser Leu Gly Gly Asn Leu
1460 1465 1470Leu Asn Pro Asn Asn Ser Ser Val Leu Asp Leu Lys Asn Ser Gln Leu
1475 1480 1485Val Phe Gly Asp Gln Gly Ser Leu Asn Ile Ala Asn Ile Asp Leu Leu 1490 1495 1500Ser Asp Leu Asn Asp Asn Lys Asn Arg Val Tyr Asn Ile Ile Gln Ala505 1510 1515 1520Asp Met Asn Ser Asn Trp Tyr Glu Arg Ile Ser Phe Phe Gly Met His
1525 1530 1535Ile Asn Asp Gly Ile Tyr Asp Ala Lys Asn Gln Thr Tyr Ser Phe Thr
1540 1545 1550Asn Pro Leu Asn Asn Ala Leu Lys Ile Thr Glu Ser Phe Lys Asp Asn
1555 1560 1565Gln Leu Ser Val Thr Leu Ser Gln Ile Pro Gly Ile Lys Asn Thr Leu 1570 1575 1580Tyr Asn Ile Gly Ser Glu Ile Phe Asn Tyr Gln Lys Val Tyr Asn Asn585 1590 1595 1600Ala Asn Gly Val Tyr Ser Tyr Ser Asp Asp Ala Gln Gly Val Phe Tyr
1605 1610 1615Leu Thr Ser Asn Val Lys Gly Tyr Tyr Asn Pro Asn Gln Ser Tyr Gln
1620 1625 1630Ala Ser Gly Ser Asn Asn Thr Thr Lys Asn Asn Asn Leu Thr Ser Glu
1635 1640 1645Ser Ser Ile Ile Ser Gln Thr Tyr Asn Ala Gln Gly Asn Pro Ile Ser 1650 1655 1660Ala Leu His Ile Tyr Asn Lys Gly Tyr Asn Phe Asn Asn Ile Lys Ala665 1670 1675 1680Leu Gly Gln Met Ala Leu Lys Leu Tyr Pro Glu Ile Lys Lys Val Leu
1685 1690 1695Gly Asn Asp Phe Ser Pro Ser Ser Leu Asn Ala Leu Asn Ser Asn Ala
1700 1705 1710Leu Asn Gln Leu Thr Lys Leu Ile Thr Pro Asn Asp Trp Lys Asn Ile
1715 1720 1725Asn Glu Leu Ile Asp Asn Ala Asn Asn Ser Val Val Gln Asn Phe Asn 1730 1735 1740Asn Gly Thr Leu Ile Val Gly Ala Thr Gln Ile Gly Gln Thr Asp Thr745 1750 1755 1760Asn Ser Ala Val Val Phe Gly Gly Leu Gly Tyr Gln Thr Pro Cys Asp
1765 1770 1775Tyr Thr Asp Ile Val Cys Gln Lys Phe Arg Gly Thr Tyr Leu Gly Gln
1780 1785 1790Leu Leu Glu Ser Ser Ser Ala Asp Leu Gly Tyr Ile Asp Thr Thr Phe
1795 1800 1805Asn Ala Lys Glu Ile Tyr Leu Thr Gly Thr Leu Gly Ser Gly Asn Ala 1810 1815 1820Trp Gly Thr Gly Gly Ser Ala Ser Val Thr Phe Asn Ser Gln Thr Ser825 1830 1835 1840Leu Ile Leu Asn Gln Ala Asn Ile Val Ser Ser Gln Thr Asp Gly Ile
1845 1850 1855Phe Ser Met Leu Gly Gln Glu Gly Ile Asn Lys Val Phe Asn Gln Ala
1860 1865 1870Gly Leu Ala Asn Ile Leu Gly Glu Val Ala Val Gln Ser Ile Asn Lys
1875 1880 1885Ala Gly Gly Leu Gly Asn Leu Ile Val Asn Thr Leu Gly Ser Asn Ser 1890 1895 1900Val Ile Gly Gly Tyr Leu Thr Pro Glu Gln Lys Asn Gln Thr Leu Ser905 1910 1915 1920Gln Leu Leu Gly Gln Asn Asn Phe Asp Asn Leu Met Asn Asp Ser Gly
1925 19301935Leu Asn Thr Ala Ile Lys Asp Leu Ile Arg Gln Lys Leu Gly Phe Trp
1940 1945 1950Thr Gly Leu Val Gly Gly Leu Ala Gly Leu Gly Gly Ile Asp Leu Gln
1955 1960 1965Asn Pro Glu Lys Leu Ile Gly Ser Met Ser Ile Asn Asp Leu Leu Ser 1970 1975 1980Lys Lys Gly Leu Phe Asn Gln Ile Thr Gly Phe Ile Ser Ala Asn Asp985 1990 1995 2000Ile Gly Gln Val Ile Ser Val Met Leu Gln Asp Ile Val Lys Pro Ser
2005 2010 2015Asn Ala Leu Lys Asn Asp Val Ala Ala Leu Gly Lys Gln Met Ile Gly
2020 2025 2030Glu Phe Leu Gly Gln Asp Thr Leu Asn Ser Leu Glu Ser Leu Leu Gln
2035 2040 2045Asn Gln Gln Ile Lys Ser Val Leu Asp Lys Val Leu Ala Ala Lys Gly 2050 2055 2060Leu Gly Pro Ile Tyr Glu Gln Gly Leu Gly Asp Leu Ile Pro Asn Leu065 2070 2075 2080Gly Lys Lys Gly Leu Phe Ala Pro Tyr Gly Leu Ser Gln Val Trp Gln
2085 2090 2095Lys Gly Asp Phe Ser Phe Asn Ala Gln Gly Asn Val Phe Val Gln Asn
2100 2105 2110Ser Thr Phe Ser Asn Ala Asn Gly Gly Thr Leu Ser Phe Asn Ala Gly
2115 2120 2125Asn Ser Leu Ile Phe Ala Gly Asn Asn His Ile Ala Phe Thr Asn His 2130 2135 2140Ala Gly Thr Leu Gln Leu Leu Ser Asp Gln Val Ser Asn Ile Asn Ile145 2150 2155 2160Thr Thr Leu Asn Ala Ser Asn Gly Leu Lys Ile Asn Ala Ala Asn Asn
2165 2170 2175Asn Val Ser Val Ser Gln Gly Asn Leu Phe Val Ser Ala Ser Cys Ala
2180 2185 2190Gln Gln Ser Asp Pro Thr Thr Ala Asn Ile Ala Asn Pro Cys Ala Leu
2195 2200 2205Ser Ala Gln Ser Thr Asn Gly Ala Ser Ser Asn Asn Ala Ser Asn Asn 2210 2215 2220Ala Pro Ile Ala Leu Ser Asn Asn Asp Glu Ser Leu Met Val Ala Ala225 2230 2235 2240Asn Asp Phe Asn Phe Ser Gly Asn Ile Tyr Ala Asn Gly Val Val Asp
2245 2250 2255Phe Ser Lys Ile Lys Gly Ser Ala Asn Ile Lys Asn Leu Tyr Leu Tyr
2260 2265 2270Asn Asn Ala Gln Phe Gln Ala Asn Asn Leu Thr Ile Ser Asn Gln Ala
2275 2280 2285Val Leu Glu Lys Asn Ala Ser Phe Val Thr Asn Asn Leu Asn Ile Gln 2290 2295 2300Gly Ala Phe Asn Asn Asn Ala Thr Gln Lys Ile Glu Val Leu Gln Asn305 2310 2315 2320Leu Val Ile Ala Ser Asn Ala Ser Leu Ser Thr Gly Ile Tyr Gly Leu
2325 2330 2335Glu Val Gly Gly Ala Leu Asn Asn Ser Gly Ala Ile His Phe Asn Leu
2340 2345 2350Glu Asn Thr Gln Thr Pro Thr Pro Leu Ile Gln Ala Glu Gly Ile Ile
2355 2360 2365Asn Leu Asn Thr Thr Gln Thr Pro Phe Met Asn Val Asn Asn Ser Met 2370 2375 2380Ala Asn Asn Thr Thr Tyr Thr Leu Leu Lys Ser Ser Arg Tyr Ile Asp385 2390 2395 2400Tyr Asn Ile Asn Pro Asn Ser Leu GlnSer Tyr Leu Asn Leu Tyr Thr
2405 2410 2415Leu Ile Asn Ile Asn Gly Asn His Ile Glu Glu Lys Asn Gly Ala Leu
2420 2425 2430Thr Tyr Leu Gly Gln Arg Val Leu Leu Gln Asp Lys Gly Leu Leu Leu
2435 2440 2445Ser Val Ala Leu Pro Asn Ser Asn Asn Ala Ser Gln Asn Asn Ile Leu 2450 2455 2460Ser Leu Ser Val Leu Tyr Asn Gln Val Lys Met Ser Cys Gly Asp Lys465 2470 2475 2480Ala Met Asp Phe Thr Pro Pro Thr Leu Gln Asp Tyr Ile Val Gly Ile
2485 2490 2495Gln Gly Gln Ser Ala Leu Asn Gln Ile Glu Ala Val Gly Gly Asn Ala
2500 2505 2510Ile Lys Trp Leu Ser Thr Leu Met Met Glu Thr Lys Glu Asn Pro Phe
2515 2520 2525Phe Ala Pro Ile Tyr Leu Lys Asn His Ser Leu Asn Glu Ile Leu Gly 2530 2535 2540Val Thr Lys Asp Leu Gln Asn Thr Ala Ser Leu Ile Ser Asn Pro Asn545 2550 2555 2560Phe Arg Asp Asn Ala Thr Asn Leu Leu Glu Leu Ala Ser Tyr Thr Gln
2565 2570 2575Gln Thr Ser Arg Leu Thr Lys Leu Ser Asp Phe Arg Ser Arg Glu Gly
2580 2585 2590Glu Ser Asp Phe Ser Leu Leu Glu Leu Lys Asn Lys Arg Phe Ser Asp
2595 2600 2605Pro Asn Pro Glu Val Phe Val Lys Tyr Ser Gln Leu Ser Lys His Pro 2610 2615 2620Asn Asn Leu Trp Val Gln Gly Val Gly Gly Ala Ser Phe Ile Ser Gly625 2630 2635 2640Gly AsnGly Thr Leu Tyr Gly Leu Asn Ala Gly Tyr Asp Arg Leu Val
2645 2650 2655Lys Asn Val Ile Leu Gly Gly Tyr Val Ala Tyr Gly Tyr Ser Asp Phe
2660 2665 2670Asn Gly Asn Ile Met His Ser Leu Gly Asn Asn Val Asp Val Gly Met
2675 2680 2685Tyr Ala Arg Ala Phe Leu Lys Arg Asn Glu Phe Thr Leu Ser Ala Asn 2690 2695 2700Glu Thr Tyr Gly Gly Asn Ala Thr Ser Ile Asn Ser Ser Asn Ser Leu705 2710 2715 2720Leu Ser Val Leu Asn Gln Arg Tyr Asn Tyr Asn Thr Trp Thr Thr Ser
2725 2730 2735Val Asn Gly Asn Tyr Gly Tyr Asp Phe Met Phe Lys Gln Lys Ser Val
2740 2745 2750Val Leu Lys Pro Gln Val Gly Leu Ser Tyr His Phe Ile Gly Leu Ser
2755 2760 2765Gly Met Lys Gly Asn Asp Ala Ala Tyr Lys Gln Phe Leu Met His Ser 2770 2775 2780Asn Pro Ser Asn Glu Ser Val Leu Thr Leu Asn Met Gly Leu Glu Ser785 2790 2795 2800Arg Lys Tyr Phe Gly Lys Asn Ser Tyr Tyr Phe Val Thr Ala Arg Leu
2805 2810 2815Gly Arg Asp Leu Leu Ile Lys Ser Lys Gly Ser Asn Thr Val Arg Phe
2820 2825 2830Val Gly Glu Asn Thr Leu Leu Tyr Arg Lys Gly Glu Val Phe Asn Thr
2835 2840 2845Phe Ala Ser Val Ile Thr Gly Gly Glu Met His Leu Trp Arg Leu Val 2850 2855 2860Tyr Val Asn Ala Gly Val Gly Leu Lys Met Gly Leu Gln Tyr Gln Asp8652870 2875 2880Ile Asn Ile Thr Gly Asn Val Gly Met Arg Val Ala Phe
2885 2890
(2) Sequence 1257 data:
(i) sequence characteristics:
(A) length: 1075bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 32...1048
(D) Other information:
(xi) Description of the sequence: sequence 1257: GGAACTCTCA TCAAAAAACAAGGAACATAAT ATG AGA CAT GGA GAT ATT AGT 52
Met Arg His Gly Asp Ile Ser
1 5AGC AGC CCA GAT ACT GTG GGT GTA GCG GTA GTT AAT TAT AAG ATG CCT 100Ser Ser Pro Asp Thr Val Gly Val Ala Val Val Asn Tyr Lys Met Pro
10 15 20AGA CTC CAC ACT AAG AAT GAG GTG TTG GAA AAT TGT CGC AAT ATC GCT 148Arg Leu His Thr Lys Asn Glu Val Leu Glu Asn Cys Arg Asn Ile Ala
25 30 35AAG GTG ATT GGT GGG GTC AAA CAG GGT TTG CCT GGG TTG GAT CTG ATT 196Lys Val Ile Gly Gly Val Lys Gln Gly Leu Pro Gly Leu Asp Leu Ile40 45 50 55ATT TTC CCT GAA TAC AGC ACG CAT GGG ATT ATG TAT GAC AGA CAA GAA 244Ile Phe Pro Glu Tyr Ser Thr His Gly Ile Met Tyr Asp Arg Gln Glu
60 65 70ATG TTT GAT ACA GCC GCA AGC GTT CCT GGA GAA GAA ACC GCG ATC TTT 292Met Phe Asp Thr Ala Ala Ser Val Pro Gly Glu Glu Thr Ala Ile Phe
75 80 85GCT GAA GCT TGT AAG AAA AAC AAG GTT TGG GGA GTG TTC TCT TTG ACA 340Ala Glu Ala Cys Lys Lys Asn Lys Val Trp Gly Val Phe Ser Leu Thr
90 95 100GGG GAA AAA CAC GAG CAA GCC AAA AAG AAT CCC TAT AAC ACT TTG ATT 388Gly Glu Lys His Glu Gln Ala Lys Lys Asn Pro Tyr Asn Thr Leu Ile
105 110 115CTT GTC AAT GAT AAG GGT GAG ATC GTG CAA AAA TAC CGC AAA ATC TTG 436Leu Val Asn Asp Lys Gly Glu Ile Val Gln Lys Tyr Arg Lys Ile Leu120 125 130 135CCT TGG TGC CCT ATT GAA TGT TGG TAT CCT GGG GAT AAA ACT TAT GTG 484Pro Trp Cys Pro Ile Glu Cys Trp Tyr Pro Gly Asp Lys Thr Tyr Val
140 145 150GTT GAT GGG CCT AAG GGC TTG AAA GTT TCT TTG ATT ATT TGC GAT GAT 532Val Asp Gly Pro Lys Gly Leu Lys Val Ser Leu Ile Ile Cys Asp Asp
155 160 165GGA AAC TAC CCT GAA ATT TGG CGC GAT TGC GCG ATG CGT GGG GCA GAA 580Gly Asn Tyr Pro Glu Ile Trp Arg Asp Cys Ala Met Arg Gly Ala Glu
170 175 180CTC ATT GTG CGC TGT CAA GGT TAC ATG TAT CCG GCT AAG GAG CAA CAA 628Leu Ile Val Arg Cys Gln Gly Tyr Met Tyr Pro Ala Lys Glu Gln Gln
185 190 195ATT GCA ATA GTA AAA GCT ATG GCG TGG GCC AAT CAA TGT TAT GTA GCG 676Ile Ala Ile Val Lys Ala Met Ala Trp Ala Asn Gln Cys Tyr Val Ala200 205 210 215GTA GCG AAT GCG ACC GGT TTT GAT GGG GTG TATTCC TAT TTT GGG CAT 724Val Ala Asn Ala Thr Gly Phe Asp Gly Val Tyr Ser Tyr Phe Gly His
220 225 230TCT AGC ATT ATT GGT TTT GAC GGG CAT ACT TTG GGC GAA TGC GGG GAA 772Ser Ser Ile Ile Gly Phe Asp Gly His Thr Leu Gly Glu Cys Gly Glu
235 240 245GAA GAA AAT GGT CTT CAA TAC GCT CAA CTT TCT GTG CAA CAA ATC CGT 820Glu Glu Asn Gly Leu Gln Tyr Ala Gln Leu Ser Val Gln Gln Ile Arg
250 255 260GAT GCG AGA AAA TAC GAC CAA AGC CAA AAC CAA CTC TTC AAA CTC TTG 868Asp Ala Arg Lys Tyr Asp Gln Ser Gln Asn Gln Leu Phe Lys Leu Leu
265 270 275CAC AGA GGT TAT AGT GGG GTT TTT GCT AGT GGC GAT GGG GAT AAG GGT 916His Arg Gly Tyr Ser Gly Val Phe Ala Ser Gly Asp Gly Asp Lys Gly280 285 290 295GTG GCG GAA TGC CCT TTT GAG TTC TAT AAA ACT TGG GTG AAT GAC CCC 964Val Ala Glu Cys Pro Phe Glu Phe Tyr Lys Thr Trp Val Asn Asp Pro
300 305 310AAA AAA GCT CAA GAA AAT GTA GAA AAA ATC ACC CGC CCA AGC GTG GGT 1012Lys Lys Ala Gln Glu Asn Val Glu Lys Ile Thr Arg Pro Ser Val Gly
315 320 325GTG GCC GCT TGT CCT GTG GGC GAT TTG CCC ACG AAA TAAAGGGCAA AAGGAG 1064Val Ala Ala Cys Pro Val Gly Asp Leu Pro Thr Lys
330 335GAGGGGGGGG G 1075
(2) Sequence 1258 data:
(i) sequence characteristics:
(A) length: 339 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1258: met Arg His Gly Asp Ile Ser Ser Ser Pro Asp Thr Val Gly Val Ala 151015 Val Val Asn Tyr Lys Met Pro Arg Leu His Thr Lys Asn Glu Val Leu
20 25 30Glu Asn Cys Arg Asn Ile Ala Lys Val Ile Gly Gly Val Lys Gln Gly
35 40 45Leu Pro Gly Leu Asp Leu Ile Ile Phe Pro Glu Tyr Ser Thr His Gly
50 55 60Ile Met Tyr Asp Arg Gln Glu Met Phe Asp Thr Ala Ala Ser Val Pro65 70 75 80Gly Glu Glu Thr Ala Ile Phe Ala Glu Ala Cys Lys Lys Asn Lys Val
85 90 95Trp Gly Val Phe Ser Leu Thr Gly Glu Lys His Glu Gln Ala Lys Lys
100 105 110Asn Pro Tyr Asn Thr Leu Ile Leu Val Asn Asp Lys Gly Glu Ile Val
115 120 125Gln Lys Tyr Arg Lys Ile Leu Pro Trp Cys Pro Ile Glu Cys Trp Tyr
130 135 140Pro Gly Asp Lys Thr Tyr Val Val Asp Gly Pro Lys Gly Leu Lys Val145 150 155 160Ser Leu Ile Ile Cys Asp Asp Gly Asn Tyr Pro Glu Ile Trp Arg Asp
165 170 175Cys Ala Met Arg Gly Ala Glu Leu Ile Val Arg Cys Gln Gly Tyr Met
180 185 190Tyr Pro Ala Lys Glu Gln Gln Ile Ala Ile Val Lys Ala Met Ala Trp
195 200 205Ala Asn Gln Cys Tyr Val Ala Val Ala Asn Ala Thr Gly Phe Asp Gly
210 215 220Val Tyr Ser Tyr Phe Gly His Ser Ser Ile Ile Gly Phe Asp Gly His225 230 235 240Thr Leu Gly Glu Cys Gly Glu Glu Glu Asn Gly Leu Gln Tyr Ala Gln
245 250 255Leu Ser Val Gln Gln Ile Arg Asp Ala Arg Lys Tyr Asp Gln Ser Gln
260 265 270Asn Gln Leu Phe Lys Leu Leu His Arg Gly Tyr Ser Gly Val Phe Ala
275 280 285Ser Gly Asp Gly Asp Lys Gly Val Ala Glu Cys Pro Phe Glu Phe Tyr
290 295 300Lys Thr Trp Val Asn Asp Pro Lys Lys Ala Gln Glu Asn Val Glu Lys305 310 315 320Ile Thr Arg Pro Ser Val Gly Val Ala Ala Cys Pro Val Gly Asp Leu
325 330 335Pro Thr Lys
(2) Sequence 1259 data:
(i) sequence characteristics:
(A) length: 1722bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 40...1686
(D) Other information:
(xi) Description of the sequence: sequence 1259: ATCTCTATCC TTTATAGAAT TTGTTGTGGA GACTGGCTT ATG AAT AAT GTT TTT 54
Met Asn Asn Val Phe
1 5GTT AAG GGT TTG TTT TTT TTT CTT TTA TTG TTT GGG TTT TTT TTG AAA 102Val Lys Gly Leu Phe Phe Phe Leu Leu Leu Phe Gly Phe Phe Leu Lys
10 15 20GCT TCA GAA AGC CCA AAC GCT ACT CTT AAT CCA TCT AAA GAA AAT GTT 150Ala Ser Glu Ser Pro Asn Ala Thr Leu Asn Pro Ser Lys Glu Asn Val
25 30 35TCT GTT GAA GAG CAA AAG CGT TTT GGA GGC GTT TTA GTT TTT GCA AGA 198Ser Val Glu Glu Gln Lys Arg Phe Gly Gly Val Leu Val Phe Ala Arg
40 45 50GGC GCT GAT GGC TCG AGC ATG GAT CCT GCT TTA GTG ACT GAT GGC GAA 246Gly Ala Asp Gly Ser Ser Met Asp Pro Ala Leu Val Thr Asp Gly Glu
55 60 65AGC TAT GTA GCA ACG GGC AAT ATT TAT GAC ACG CTC GTG CAA TTC AGA 294Ser Tyr Val Ala Thr Gly Asn Ile Tyr Asp Thr Leu Val Gln Phe Arg70 75 80 85TAC GGC ACC ACA GAA GTT GAA CCC GCC TTA GCG ACA AGC TGG GAC ATA 342Tyr Gly Thr Thr Glu Val Glu Pro Ala Leu Ala Thr Ser Trp Asp Ile
90 95 100TCC CCA GAT GGT CTT GTA TAT ACC TTT CAT TTA CGC AAA GGG GTT TAT 390Ser Pro Asp Gly Leu Val Tyr Thr Phe His Leu Arg Lys Gly Val Tyr
105 110 115TTC CAC CAA ACG AAG TAT TGG AAT AAA AAA GTA GAG TTT AGC GCT AAA 438Phe His Gln Thr Lys Tyr Trp Asn Lys Lys Val Glu Phe Ser Ala Lys
120 125 130GAT GTG CTG TTT TCG TTT GAA CGC CAG ATG GAT AAA GCT AAA CGA TAT 486Asp Val Leu Phe Ser Phe Glu Arg Gln Met Asp Lys Ala Lys Arg Tyr
135 140 145TAT AGC CCG GGG GCT AAA AGC TAT AAG TAT TGG GAA GGC ATG GGC ATG 534Tyr Ser Pro Gly Ala Lys Ser Tyr Lys Tyr Trp Glu Gly Met Gly Met150 155 160 165TCT CAT ATT ATT AAG AGC ATT GAA GCT TTA GAT GAC TAT ACC ATT AGA 582Ser His Ile Ile Lys Ser Ile Glu Ala Leu Asp Asp Tyr Thr Ile Arg
170 175 180TTC ACA CTT AAT GGG CCA GAA GCC CCG TTT TTA GCG AAT TTG GGC ATG 630Phe Thr Leu Asn Gly Pro Glu Ala Pro Phe Leu Ala Asn Leu Gly Met
185 190 195GAC TTT TTG AGC ATT TTG AGT AAG GAT TAC GCT GAT TAC CTG GCT CAA 678Asp Phe Leu Ser Ile Leu Ser Lys Asp Tyr Ala Asp Tyr Leu Ala Gln
200 205 210AAT AAT AAA AAA GAC GAG TTG GCT AAA AAA CCT ATT GGG ACA GGG CCT 726Asn Asn Lys Lys Asp Glu Leu Ala Lys Lys Pro Ile Gly Thr Gly Pro
215 220 225TTC AAA TTC TTT TTG TGG AAT AAA GAT GAA AAA ATC ATT CTT TTA AAA 774Phe Lys Phe Phe Leu Trp Asn Lys Asp Glu Lys Ile Ile Leu Leu Lys230 235 240 245AAT CAA GAT TAT TGG GGG CCT AAA GCG TAT TTG GAT AAG GTG GTG GTG 822Asn Gln Asp Tyr Trp Gly Pro Lys Ala Tyr Leu Asp Lys Val Val Val
250 255 260CGC ACC ATT CCT AAT TCT TCC ACT CGC GCT TTA GCG TTG CGC ACC GGC 870Arg Thr Ile Pro Asn Ser Ser Thr Arg Ala Leu Ala Leu Arg Thr Gly
265 270 275GAA ATC ATG CTC ATG ACT GGG CCT AAT CTC AAT GAA GTG GAG CAA TTA 918Glu Ile Met Leu Met Thr Gly Pro Asn Leu Asn Glu Val Glu Gln Leu
280 285 290GAA AAA GTC CCT AAT ATC GTG GTG GAC AAA AGT GCT GGG TTG TTG GCG 966Glu Lys Val Pro Asn Ile Val Val Asp Lys Ser Ala Gly Leu Leu Ala
295 300 305AGT TGG CTT TCG TTG AAC ACG CAA AAA AAG TAT TTT GAC AAC CCT TTG 1014Ser Trp Leu Ser Leu Asn Thr Gln Lys Lys Tyr Phe Asp Asn Pro Leu310 315 320 325GTG CGT TTG GCT ATC AAT CAT GCG ATC AAT GCA GAT GAT TAC ATC AAA 1062Val Arg Leu Ala Ile Asn His Ala Ile Asn Ala Asp Asp Tyr Ile Lys
330 335 340GTG CTT TAT GAA GGC TTT GCT CAA AAA ATG GTC AAT CCT TTC CCG CCC 1110Val Leu Tyr Glu Gly Phe Ala Gln Lys Met Val Asn Pro Phe Pro Pro
345 350 355ACC ATA TGG GGT TAT AAC TAC AAT ATC AAA CCC TAT GAA TAC GAT TTG 1158Thr Ile Trp Gly Tyr Asn Tyr Asn Ile Lys Pro Tyr Glu Tyr Asp Leu
360 365 370AAA AAG GCT AAG GAG TTG TTG AAA CAA GCG GGC TAT CCT AAC GGC TTT 1206Lys Lys Ala Lys Glu Leu Leu Lys Gln Ala Gly Tyr Pro Asn Gly Phe
375 380 385AAA ACC ACT ATT TTT ACC ACT GCC ACT CGT AAC CCA AAA GGA GCG GTG 1254Lys Thr Thr Ile Phe Thr Thr Ala Thr Arg Asn Pro Lys Gly Ala Val390 395 400 405TTC ATA CAG GCG AGC CTG GCT AAA ATT GGC ATT GAT GTG AAA ATT GAA 1302Phe Ile Gln Ala Ser Leu Ala Lys Ile Gly Ile Asp Val Lys Ile Glu
410 415 420GTG TAT GAG TGG GGG GCT TAT TTG AAA AGA ACG GGT CTG GGC GAA CAT 1350Val Tyr Glu Trp Gly Ala Tyr Leu Lys Arg Thr Gly Leu Gly Glu His
425 430 435GAA ATG GCG TTT TCA GGC TGG ATG GCA GAC ATT GCG GAT CCG GAT AAT 1398Glu Met Ala Phe Ser Gly Trp Met Ala Asp Ile Ala Asp Pro Asp Asn
440 445 450TTC TTA TAC ACC TTA TGG AGC GAG CAA GCC GCC TCA GCT ATA CCC ACT 1446Phe Leu Tyr Thr Leu Trp Ser Glu Gln Ala Ala Ser Ala Ile Pro Thr
455 460 465CAA AAC CAT TCC TTT TAT AAA AAT AAG GAG TTT TCC AAT CTG CTC ATA 1494Gln Asn His Ser Phe Tyr Lys Asn Lys Glu Phe Ser Asn Leu Leu Ile470 475 480 485AAG GCT AAA CGC GTT TCG GAT CAA AAA GAG AGG GAA GCC CTT TAT TTA 1542Lys Ala Lys Arg Val Ser Asp Gln Lys Glu Arg Glu Ala Leu Tyr Leu
490 495 500AAG GCA CAA GAA ATT ATC CAT AAA GAC GCG CCT TAT GTG CCT TTA GCC 1590Lys Ala Gln Glu Ile Ile His Lys Asp Ala Pro Tyr Val Pro Leu Ala
505 510 515TAT CCT TAT TCG GTG GTG CCG CAT TTG TCT AAA GTT AAG GGT TAT AAA 1638Tyr Pro Tyr Ser Val Val Pro His Leu Ser Lys Val Lys Gly Tyr Lys
520 525 530ACG ACC GGA GTG AGC GTG AAT CGC TTC TTT AAG GTG TAT TTA GAA AAA T 1687Thr Thr Gly Val Ser Val Asn Arg Phe Phe Lys Val Tyr Leu Glu Lys
535 540 545AAAAGGGGTT GCATGCTGAG TTTTATCATT AAGCG 1722
(2) Data on sequence 1260:
(i) sequence characteristics:
(A) length: 549 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1260: met Asn Asn Val Phe Val Lys Gly Leu Phe Phe Phe Leu Leu Leu Phe 151015 Gly Phe Phe Leu Lys Ala Ser Glu Ser Pro Asn Ala Thr Leu Asn Pro
20 25 30Ser Lys Glu Asn Val Ser Val Glu Glu Gln Lys Arg Phe Gly Gly Val
35 40 45Leu Val Phe Ala Arg Gly Ala Asp Gly Ser Ser Met Asp Pro Ala Leu
50 55 60Val Thr Asp Gly Glu Ser Tyr Val Ala Thr Gly Asn Ile Tyr Asp Thr65 70 75 80Leu Val Gln Phe Arg Tyr Gly Thr Thr Glu Val Glu Pro Ala Leu Ala
85 90 95Thr Ser Trp Asp Ile Ser Pro Asp Gly Leu Val Tyr Thr Phe His Leu
100 105 110Arg Lys Gly Val Tyr Phe His Gln Thr Lys Tyr Trp Asn Lys Lys Val
115 120 125Glu Phe Ser Ala Lys Asp Val Leu Phe Ser Phe Glu Arg Gln Met Asp
130 135 140Lys Ala Lys Arg Tyr Tyr Ser Pro Gly Ala Lys Ser Tyr Lys Tyr Trp145 50 155 160Glu Gly Met Gly Met Ser His Ile Ile Lys Ser Ile Glu Ala Leu Asp
165 170 175Asp Tyr Thr Ile Arg Phe Thr Leu Asn Gly Pro Glu Ala Pro Phe Leu
180 185 190Ala Asn Leu Gly Met Asp Phe Leu Ser Ile Leu Ser Lys Asp Tyr Ala
195 200 205Asp Tyr Leu Ala Gln Asn Asn Lys Lys Asp Glu Leu Ala Lys Lys Pro
210 215 220Ile Gly Thr Gly Pro Phe Lys Phe Phe Leu Trp Asn Lys Asp Glu Lys225 230 235 240Ile Ile Leu Leu Lys Asn Gln Asp Tyr Trp Gly Pro Lys Ala Tyr Leu
245 250 255Asp Lys Val Val Val Arg Thr Ile Pro Asn Ser Ser Thr Arg Ala Leu
260 265 270Ala Leu Arg Thr Gly Glu Ile Met Leu Met Thr Gly Pro Asn Leu Asn
275 280 285Glu Val Glu Gln Leu Glu Lys Val Pro Asn Ile Val Val Asp Lys Ser
290 295 300Ala Gly Leu Leu Ala Ser Trp Leu Ser Leu Asn Thr Gln Lys Lys Tyr305 310 315 320Phe Asp Asn Pro Leu Val Arg Leu Ala Ile Asn His Ala Ile Asn Ala
325 330 335Asp Asp Tyr Ile Lys Val Leu Tyr Glu Gly Phe Ala Gln Lys Met Val
340 345 350Asn Pro Phe Pro Pro Thr Ile Trp Gly Tyr Asn Tyr Asn Ile Lys Pro
355 360 365Tyr Glu Tyr Asp Leu Lys Lys Ala Lys Glu Leu Leu Lys Gln Ala Gly
370 375 380Tyr Pro Asn Gly Phe Lys Thr Thr Ile Phe Thr Thr Ala Thr Arg Asn385 390 395 400Pro Lys Gly Ala Val Phe Ile Gln Ala Ser Leu Ala Lys Ile Gly Ile
405 410 415Asp Val Lys Ile Glu Val Tyr Glu Trp Gly Ala Tyr Leu Lys Arg Thr
420 425 430Gly Leu Gly Glu His Glu Met Ala Phe Ser Gly Trp Met AlaAsp Ile
435 440 445Ala Asp Pro Asp Asn Phe Leu Tyr Thr Leu Trp Ser Glu Gln Ala Ala
450 455 460Ser Ala Ile Pro Thr Gln Asn His Ser Phe Tyr Lys Asn Lys Glu Phe465 470 475 480Ser Asn Leu Leu Ile Lys Ala Lys Arg Val Ser Asp Gln Lys Glu Arg
485 490 495Glu Ala Leu Tyr Leu Lys Ala Gln Glu Ile Ile His Lys Asp Ala Pro
500 505 510Tyr Val Pro Leu Ala Tyr Pro Tyr Ser Val Val Pro His Leu Ser Lys
515 520 525Val Lys Gly Tyr Lys Thr Thr Gly Val Ser Val Asn Arg Phe Phe Lys
530 535 540Val Tyr Leu Glu Lys545
(2) Data of sequence 1261:
(i) sequence characteristics:
(A) length: 1080bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...1050
(D) Other information:
(xi) Description of the sequence: sequence 1261: GCGTGAATCG CTTCTTTAAG GTGTATTTAG AAAAATAAAA GGGGTTGC ATG CTG AGT 57
Met Leu Ser
1TTT ATC ATT AAG CGT ATT TTG TGG GCG ATC CCC ACG CTG TTT GGA GTG 105Phe Ile Ile Lys Arg Ile Leu Trp Ala Ile Pro Thr Leu Phe Gly Val
5 10 15AGT ATC ATT GTG TTT ATG ATG GTG CAT TTA GTG CCA GGA GAT CCG GCA 153Ser Ile Ile Val Phe Met Met Val His Leu Val Pro Gly Asp Pro Ala20 25 30 35TTA GTG ATT TTA GGT GAA AAG GCC AAT CAA GCC GCT ATT GAT GCT TTA 201Leu Val Ile Leu Gly Glu Lys Ala Asn Gln Ala Ala Ile Asp Ala Leu
40 45 50AGA GAG CAA TTT GGA TTG AAT AAG CCC TTG ATA GAG CAG TAT TTT TTC 249Arg Glu Gln Phe Gly Leu Asn Lys Pro Leu Ile Glu Gln Tyr Phe Phe
55 60 65TTT ATC AAT AAT GTG TTG CAT GGC AAT TTT GGC ACT TCT ATC ATG ACC 297Phe Ile Asn Asn Val Leu His Gly Asn Phe Gly Thr Ser Ile Met Thr
70 75 80GGT GAG CCT GTG ATG CAT GAG TTT TGG CAA CGC TTC CCG GCC ACG GTG 345Gly Glu Pro Val Met His Glu Phe Trp Gln Arg Phe Pro Ala Thr Val
85 90 95GAA TTA GCT TTG ATC GCT CTG TTT ATG GCT CTT GTT TTG GGT ATT AGC 393Glu Leu Ala Leu Ile Ala Leu Phe Met Ala Leu Val Leu Gly Ile Ser100 105 110 115GTT GGC GTG TTA GCT GCG ATC AAA CGC TAT AGC GTG TTT GAT TAT TCC 441Val Gly Val Leu Ala Ala Ile Lys Arg Tyr Ser Val Phe Asp Tyr Ser
120 125 130AGC ATG ACT TTT GCT TTA GCC GGG ATT TCT ATG CCG GTG TTT TGG CTA 489Ser Met Thr Phe Ala Leu Ala Gly Ile Ser Met Pro Val Phe Trp Leu
135 140 145GGG CTC ATG CTG ATT TAT ATC TTT AGC GTG CAA TTG GGG TGG TTG CCT 537Gly Leu Met Leu Ile Tyr Ile Phe Ser Val Gln Leu Gly Trp Leu Pro
150 155 160GTT TTT GGG CGT TTG AGC GAT GTG TAT TAT TTA GAT GGC CCC ACA GGT 585Val Phe Gly Arg Leu Ser Asp Val Tyr Tyr Leu Asp Gly Pro Thr Gly
165 170 175CTT TAT TTG ATA GAC AGC CTG ATC GCA AGG GAT TAT GGG GCG TTT ATG 633Leu Tyr Leu Ile Asp Ser Leu Ile Ala Arg Asp Tyr Gly Ala Phe Met180 185 190 195GAT ACG ATC AAG CAC TTG ATT TTG CCT AGC ATT GTG TTA GCC ACG GTT 681Asp Thr Ile Lys His Leu Ile Leu Pro Ser Ile Val Leu Ala Thr Val
200 205 210TCT ACC GCT GTT ATT GCC AGA ATG ACT CGC GCG AGC ATG GCA GAA GTG 729Ser Thr Ala Val Ile Ala Arg Met Thr Arg Ala Ser Met Ala Glu Val
215 220 225TCT AAA GAA GAT TAT GTG CGT ACC GCT AAA GCT AAG GGG TGT AGC TCC 777Ser Lys Glu Asp Tyr Val Arg Thr Ala Lys Ala Lys Gly Cys Ser Ser
230 235 240TTT AGG GTG ATT TTT GTG CAC ACT TTG CGT AAT GCT TTA ATC CCT GTA 825Phe Arg Val Ile Phe Val His Thr Leu Arg Asn Ala Leu Ile Pro Val
245 250 255ACG ACT ATC GCA GGC TTG ATG TTG GCC GGG CTT TTA GGG GGG AGC ATG 873Thr Thr Ile Ala Gly Leu Met Leu Ala Gly Leu Leu Gly Gly Ser Met260 265 270 275ATA ACT GAA ACG GTT TTC TCA TGG CCT GGG ATT GGT AAG TGG ATT GTT 921Ile Thr Glu Thr Val Phe Ser Trp Pro Gly Ile Gly Lys Trp Ile Val
280 285 290AAT GCG CTC AAC CAG CGC GAT TTC CCG ATT ATC CAG TCC ATG TCT TTG 969Asn Ala Leu Asn Gln Arg Asp Phe Pro Ile Ile Gln Ser Met Ser Leu
295 300 305ATT ATT GCC ATG ATG TAT ATT GGG GCT AAT CTC TTA GTG GAT ATT TTA 1017Ile Ile Ala Met Met Tyr Ile Gly Ala Asn Leu Leu Val Asp Ile Leu
310 315 320TAC GCT TTT ATT GAT CCT AGA ATA AGG TTG TCA TAATGGAGTC TTTTAGAGAG 1070Tyr Ala Phe Ile Asp Pro Arg Ile Arg Leu Ser
325 330TTTATCCAAC 1080
(2) Sequence 1262 data:
(i) sequence characteristics:
(A) length: 334 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1262: met Leu Ser Phe Ile Ile Lys Arg Ile Leu Trp Ala Ile Pro Thr Leu 151015 Phe Gly Val Ser Ile Ile Val Phe Met Met Val His Leu Val Pro Gly
20 25 30Asp Pro Ala Leu Val Ile Leu Gly Glu Lys Ala Asn Gln Ala Ala Ile
35 40 45Asp Ala Leu Arg Glu Gln Phe Gly Leu Asn Lys Pro Leu Ile Glu Gln
50 55 60Tyr Phe Phe Phe Ile Asn Asn Val Leu His Gly Asn Phe Gly Thr Ser65 70 75 80Ile Met Thr Gly Glu Pro Val Met His Glu Phe Trp Gln Arg Phe Pro
85 90 95Ala Thr Val Glu Leu Ala Leu Ile Ala Leu Phe Met Ala Leu Val Leu
100 105 110Gly Ile SerVal Gly Val Leu Ala Ala Ile Lys Arg Tyr Ser Val Phe
115 120 125Asp Tyr Ser Ser Met Thr Phe Ala Leu Ala Gly Ile Ser Met Pro Val
130 135 140Phe Trp Leu Gly Leu Met Leu Ile Tyr Ile Phe Ser Val Gln Leu Gly145 150 155 160Trp Leu Pro Val Phe Gly Arg Leu Ser Asp Val Tyr Tyr Leu Asp Gly
165 170 175Pro Thr Gly Leu Tyr Leu Ile Asp Ser Leu Ile Ala Arg Asp Tyr Gly
180 185 190Ala Phe Met Asp Thr Ile Lys His Leu Ile Leu Pro Ser Ile Val Leu
195 200 205Ala Thr Val Ser Thr Ala Val Ile Ala Arg Met Thr Arg Ala Ser Met
210 215 220Ala Glu Val Ser Lys Glu Asp Tyr Val Arg Thr Ala Lys Ala Lys Gly225 230 235 240Cys Ser Ser Phe Arg Val Ile Phe Val His Thr Leu Arg Asn Ala Leu
245 250 255Ile Pro Val Thr Thr Ile Ala Gly Leu Met Leu Ala Gly Leu Leu Gly
260 265 270Gly Ser Met Ile Thr Glu Thr Val Phe Ser Trp Pro Gly Ile Gly Lys
275 280 285Trp Ile Val Asn Ala Leu Asn Gln Arg Asp Phe Pro Ile Ile Gln Ser
290 295 300Met Ser Leu Ile Ile Ala Met Met Tyr Ile Gly Ala Asn Leu Leu Val305 310 315 320Asp Ile Leu Tyr Ala Phe Ile Asp Pro Arg Ile Arg Leu Ser
325 330
(2) Sequence 1263 data:
(i) sequence characteristics:
(A) length: 955bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 32...892
(D) Other information:
(xi) Description of the sequence: sequence 1263: ATCCTAAACG CACCTCTTAAAAGGAGCTTG C ATG ATT TTA GAA GTT AAA GAT 52
Met Ile Leu Glu Val Lys Asp
1 5TTA AAA ACT TAT TTT TTC ACC GAT AAG GGC GTG AAT AAA GCA GTG GAT 100Leu Lys Thr Tyr Phe Phe Thr Asp Lys Gly Val Asn Lys Ala Val Asp
10 15 20GGT GTG AGT TTT GGT TTG AAA AAG TCT CAA ACG CTC TGC ATT GTA GGG 148Gly Val Ser Phe Gly Leu Lys Lys Ser Gln Thr Leu Cys Ile Val Gly
25 30 35GAG AGC GGG AGC GGG AAA AGC ATC ACT TCG CTC TCT ATT TTA GGG TTG 196Glu Ser Gly Ser Gly Lys Ser Ile Thr Ser Leu Ser Ile Leu Gly Leu40 45 50 55ATT GAA AAA CCG GGT CAA ATT GTG GGA GGG AGC ATT CAA TTT TTA GGG 244Ile Glu Lys Pro Gly Gln Ile Val Gly Gly Ser Ile Gln Phe Leu Gly
60 65 70CAG GAT TTG TTG CAA CTC AAA GAA AAG CAG ATG CAA AAA GAA ATT AGG 292Gln Asp Leu Leu Gln Leu Lys Glu Lys Gln Met Gln Lys Glu Ile Arg
75 80 85GGT AAA AAA ATT GGC ATG ATC TTT CAA GAG CCT ATG ACA AGC CTA AAC 340Gly Lys Lys Ile Gly Met Ile Phe Gln Glu Pro Met Thr Ser Leu Asn
90 95 100CCT TCC TAC ACG GTG GGG TTT CAA ATC AAT GAA GTG TTG AAA ATC CAC 388Pro Ser Tyr Thr Val Gly Phe Gln Ile Asn Glu Val Leu Lys Ile His
105 110 115CAC CCT AAC CTC AAT AAA AAA GAA CGC TTA GAA AGG GTG GTT TAT GAA 436His Pro Asn Leu Asn Lys Lys Glu Arg Leu Glu Arg Val Val Tyr Glu120 125 130 135TTA GAG CGT GTG GGC ATT CCC CAT GCA GGG GAT AAA TAC CAC GAA TAC 484Leu Glu Arg Val Gly Ile Pro His Ala Gly Asp Lys Tyr His Glu Tyr
140 145 150CCT TTC AAT CTC AGC GGG GGG CAG CGC CAA AGG GTG ATG ATC GCT ATG 532Pro Phe Asn Leu Ser Gly Gly Gln Arg Gln Arg Val Met Ile Ala Met
155 160 165GCT ATG GTG TGT GAG CCT GAA ATC TTG ATC GCT GAT GAG CCT ACG ACA 580Ala Met Val Cys Glu Pro Glu Ile Leu Ile Ala Asp Glu Pro Thr Thr
170 175 180GCC TTA GAT GTA ACC ATT CAA GCG CAA ATT TTA GAA TTG ATG AAA GAA 628Ala Leu Asp Val Thr Ile Gln Ala Gln Ile Leu Glu Leu Met Lys Glu
185 190 195TTG CAA CAA AAA AAA GGC ACT TCT ATT TTG TTT ATC ACC CAT GAT TTA 676Leu Gln Gln Lys Lys Gly Thr Ser Ile Leu Phe Ile Thr His Asp Leu200 205 210 215GGC GTG GTG GCG CAA ATC GCT GAT GAA GTG GTG GTG ATG TAT AAA GGG 724Gly Val Val Ala Gln Ile Ala Asp Glu Val Val Val Met Tyr Lys Gly
220 225 230CAT GTG GTGGAG CAA GCG AGT GCG AAA GAG CTT TTT GCT GAT CCA AGA 772His Val Val Glu Gln Ala Ser Ala Lys Glu Leu Phe Ala Asp Pro Arg
235 240 245CAC CCT TAT ACG AAA GCT CTT TTA AGC GCG ATC CCT AAA CCG GGC AAA 820His Pro Tyr Thr Lys Ala Leu Leu Ser Ala Ile Pro Lys Pro Gly Lys
250 255 260GAA TAC CGC AAA AAA CGC TTA GAG ACC GTG GAT GAA AAT GTG GAT TAT 868Glu Tyr Arg Lys Lys Arg Leu Glu Thr Val Asp Glu Asn Val Asp Tyr
265 270 275TTG AGT TTT CAA AAG GAG TTG CGA TGAAGCTCTT AGAAATTAAA GAATTGAAAA 922Leu Ser Phe Gln Lys Glu Leu Arg280 285AATCCTATGC GATAGACAGG GGGTTATTCA AGC 955
(2) Sequence 1264 data:
(i) sequence characteristics:
(A) length: 287 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1264: met Ile Leu Glu Val Lys Asp Leu Lys Thr Tyr Phe Phe Thr Asp Lys 151015 Gly Val Asn Lys Ala Val Asp Gly Val Ser Phe Gly Leu Lys Lys Ser
20 25 30Gln Thr Leu Cys Ile Val Gly Glu Ser Gly Ser Gly Lys Ser Ile Thr
35 40 45Ser Leu Ser Ile Leu Gly Leu Ile Glu Lys Pro Gly Gln Ile Val Gly
50 55 60Gly Ser Ile Gln Phe Leu Gly Gln Asp Leu Leu Gln Leu Lys Glu Lys65 70 75 80Gln Met Gln Lys Glu Ile Arg Gly Lys Lys Ile Gly Met Ile Phe Gln
85 90 95Glu Pro Met Thr Ser Leu Asn Pro Ser Tyr Thr Val Gly Phe Gln Ile
100 105 110Asn Glu Val Leu Lys Ile His His Pro Asn Leu Asn Lys Lys Glu Arg
115 120 125Leu Glu Arg Val Val Tyr Glu Leu Glu Arg Val Gly Ile Pro His Ala
130 135 140Gly Asp Lys Tyr His Glu Tyr Pro Phe Asn Leu Ser Gly Gly Gln Arg145 150 155 160Gln Arg Val Met Ile Ala Met Ala Met Val Cys Glu Pro Glu Ile Leu
165 170 175Ile Ala Asp Glu Pro Thr Thr Ala Leu Asp Val Thr Ile Gln Ala Gln
180 185 190Ile Leu Glu Leu Met Lys Glu Leu Gln Gln Lys Lys Gly Thr Ser Ile
195 200 205Leu Phe Ile Thr His Asp Leu Gly Val Val Ala Gln Ile Ala Asp Glu
210 215 220Val Val Val Met Tyr Lys Gly His Val Val Glu Gln Ala Ser Ala Lys225 230 235 240Glu Leu Phe Ala Asp Pro Arg His Pro Tyr Thr Lys Ala Leu Leu Ser
245 250 255Ala Ile Pro Lys Pro Gly Lys Glu Tyr Arg Lys Lys Arg Leu Glu Thr
260 265 270Val Asp Glu Asn Val Asp Tyr Leu Ser Phe Gln Lys Glu Leu Arg
275 280 285
(2) Sequence 1265 data:
(i) sequence characteristics:
(A) length: 894bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 37...840
(D) Other information:
(xi) Description of the sequence: sequence 1265: AAATGTGGAT TATTTGAGTT TTCAAAAGGA GTTGCG ATG AAG CTC TTA GAA ATT 54
Met Lys Leu Leu Glu Ile
1 5AAA GAA TTG AAA AAA TCC TAT GCG ATA GAC AGG GGG TTA TTC AAG CCT 102Lys Glu Leu Lys Lys Ser Tyr Ala Ile Asp Arg Gly Leu Phe Lys Pro
10 15 20AAA AGA GTG ATC CAT GCG CTC AAT GGG ATC AGT TTT GAA GTG GAA CAA 150Lys Arg Val Ile His Ala Leu Asn Gly Ile Ser Phe Glu Val Glu Gln
25 30 35AAT GAA GTT TTG AGC ATT GTG GGG GAG AGC GGT TGC GGG AAA AGC ACG 198Asn Glu Val Leu Ser Ile Val Gly Glu Ser Gly Cys Gly Lys Ser Thr
40 45 50ACA GCC AAA ATT TTA GCC GGG ATT GAA AGG CAA GAT AGC GGG GCG ATT 246Thr Ala Lys Ile Leu Ala Gly Ile Glu Arg Gln Asp Ser Gly Ala Ile55 60 65 70TAT TTC AAT GGT AAG CGC CAT TTG CAT TTT AGC AAA CAG GAT TGG TTT 294Tyr Phe Asn Gly Lys Arg His Leu His Phe Ser Lys Gln Asp Trp Phe
75 80 85GAT TAC CGC AAA AAG GTG CAA ATGATT TTT CAA GAC CCT TAT TCT AGC 342Asp Tyr Arg Lys Lys Val Gln Met Ile Phe Gln Asp Pro Tyr Ser Ser
90 95 100CTA AAC CCT CGG TGG AAA GTG GGC GAG ATC ATC GCT GAA CCC TTG CTT 390Leu Asn Pro Arg Trp Lys Val Gly Glu Ile Ile Ala Glu Pro Leu Leu
105 110 115TTA AAT TCT CAT TTT TCA AAA AAA GAA ATC AAA ACA AAA GTG CTA GAG 438Leu Asn Ser His Phe Ser Lys Lys Glu Ile Lys Thr Lys Val Leu Glu
120 125 130ATC ATG CAA AAA GTG GGC TTG AAA TTA GAA TGG ATC GAT CGT TAC CCC 486Ile Met Gln Lys Val Gly Leu Lys Leu Glu Trp Ile Asp Arg Tyr Pro135 140 145 150CAC CAA TTT TCA GGC GGT CAA AGG CAA CGA ATC GGC ATT GCT AGG GCG 534His Gln Phe Ser Gly Gly Gln Arg Gln Arg Ile Gly Ile Ala Arg Ala
155 160 165CTC ATT TTG CAT CCT AGC GTG GTG ATT TGC GAT GAG CCT GTG TCT GCG 582Leu Ile Leu His Pro Ser Val Val Ile Cys Asp Glu Pro Val Ser Ala
170 175 180CTA GAC GTG TCC ATT CAA GCG CAA GTG TTG AAT TTG CTC TTG GAT TTG 630Leu Asp Val Ser Ile Gln Ala Gln Val Leu Asn Leu Leu Leu Asp Leu
185 190 195CAA AAA GAA ATG GGG CTG ACT TAT ATT TTT ATC AGC CAT GAT TTA GGG 678Gln Lys Glu Met Gly Leu Thr Tyr Ile Phe Ile Ser His Asp Leu Gly
200 205 210GTG GTG GAG CAT ATA AGC GAT AAA ATC ATC GTA ATG AAT CAG GGG CAA 726Val Val Glu His Ile Ser Asp Lys Ile Ile Val Met Asn Gln Gly Gln215 220 225 230ATC GTA GAA ACG GGG GAT GTG GAT AGC GTG ATA AGC GCT CCA AAG CAC 774Ile Val Glu Thr Gly Asp Val Asp Ser Val Ile SerAla Pro Lys His
235 240 245CCT TAT ACG CAG AAA TTA CTC AAT GCG GTG CCG CAT TTG GAA AAA TCC 822Pro Tyr Thr Gln Lys Leu Leu Asn Ala Val Pro His Leu Glu Lys Ser
250 255 260ATG CAA AGA TTT GCC AAA TAAAAGAAAG GATTTTTAAG CTGTGTTTGT AGATAGCG 878Met Gln Arg Phe Ala Lys
265TGGAAATTAT CATCGC 894
(2) Sequence 1266 data:
(i) sequence characteristics:
(A) length: 268 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1266: met Lys Leu Leu Glu Ile Lys Glu Leu Lys Lys Ser Tyr Ala Ile Asp 151015 Arg Gly Leu Phe Lys Pro Lys Arg Val Ile His Ala Leu Asn Gly Ile
20 25 30Ser Phe Glu Val Glu Gln Asn Glu Val Leu Ser Ile Val Gly Glu Ser
35 40 45Gly Cys Gly Lys Ser Thr Thr Ala Lys Ile Leu Ala Gly Ile Glu Arg
50 55 60Gln Asp Ser Gly Ala Ile Tyr Phe Asn Gly Lys Arg His Leu His Phe65 70 75 80Ser Lys Gln Asp Trp Phe Asp Tyr Arg Lys Lys Val Gln Met Ile Phe
85 90 95Gln Asp Pro Tyr Ser Ser Leu Asn Pro Arg Trp Lys Val Gly Glu Ile
100 105110Ile Ala Glu Pro Leu Leu Leu Asn Ser His Phe Ser Lys Lys Glu Ile
115 120 125Lys Thr Lys Val Leu Glu Ile Met Gln Lys Val Gly Leu Lys Leu Glu
130 135 140Trp Ile Asp Arg Tyr Pro His Gln Phe Ser Gly Gly Gln Arg Gln Arg145 150 155 160Ile Gly Ile Ala Arg Ala Leu Ile Leu His Pro Ser Val Val Ile Cys
165 170 175Asp Glu Pro Val Ser Ala Leu Asp Val Ser Ile Gln Ala Gln Val Leu
180 185 190Asn Leu Leu Leu Asp Leu Gln Lys Glu Met Gly Leu Thr Tyr Ile Phe
195 200 205Ile Ser His Asp Leu Gly Val Val Glu His Ile Ser Asp Lys Ile Ile
210 215 220Val Met Asn Gln Gly Gln Ile Val Glu Thr Gly Asp Val Asp Ser Val225 230 235 240Ile Ser Ala Pro Lys His Pro Tyr Thr Gln Lys Leu Leu Asn Ala Val
245 250 255Pro His Leu Glu Lys Ser Met Gln Arg Phe Ala Lys
260 265
(2) Sequence 1267 data:
(i) sequence characteristics:
(A) length: 1141bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: codingsequence
(B) Position: 62...1087
(D) Other information:
(xi) Description of the sequence: sequence 1267: TTAAGCTGTG TTTGTAGATA GCGTGGAAAT TATCATCGCT TCGGGTAAGG GGGGGCCTGG 60A ATG GTG AGT TTT AGG CGA GAA AAA TTT GTC ATC AAA GGA GGC CCT GAT 109 Met Val Ser Phe Arg Arg Glu Lys Phe Val Ile Lys Gly Gly Pro Asp 151015 GGG GGC GAT GGA GGC GAT GGA GGC GAT GTG TAT TTT GAA GTG GAT AAC 157Gly Gly Asp Gly Gly Asp Gly Gly Asp Val Tyr Phe Glu Val Asp Asn
20 25 30AAT ACC GAC ACT CTA GCG AGT TTT AGA GGC ACC AAA CAC CAT AAG GCT 205Asn Thr Asp Thr Leu Ala Ser Phe Arg Gly Thr Lys His His Lys Ala
35 40 45AAA AAT GGG GCT CCA GGA GGT ACA CGA AAT TGC GCG GGC AAA AAG GGC 253Lys Asn Gly Ala Pro Gly Gly Thr Arg Asn Cys Ala Gly Lys Lys Gly
50 55 60GAA GAC AAG ATC ATT GTC GTG CCA CCA GGA ACG CAG GTT TTT GTA GGT 301Glu Asp Lys Ile Ile Val Val Pro Pro Gly Thr Gln Val Phe Val Gly65 70 75 80GAT GAG TTG TGG CTT GAT TTA GTG GAA CCT AAA GAA AGG GTG TTA GCC 349Asp Glu Leu Trp Leu Asp Leu Val Glu Pro Lys Glu Arg Val Leu Ala
85 90 95TTA AAA GGG GGC AAG GGG GGG TTA GGG AAT GCA CAT TTT AAA AGC GCG 397Leu Lys Gly Gly Lys Gly Gly Leu Gly Asn Ala His Phe Lys Ser Ala
100 105 110ACT AAA CAA CAA CCC ACT TAC GCG CAA AAA GGC TTA GAG GGG GTT GAA 445Thr Lys Gln Gln Pro Thr Tyr Ala Gln Lys Gly Leu Glu Gly Val Glu
115 120 125AAA TGC GTG CGT TTG GAA TTA AAA CTC ATC GCT GAT ATA GGG TTA GTG 493Lys Cys ValArg Leu Glu Leu Lys Leu Ile Ala Asp Ile Gly Leu Val
130 135 140GGC TTC CCT AAT GCG GGT AAA TCC ACG CTC ATT TCC ACC ATC TCT AAC 541Gly Phe Pro Asn Ala Gly Lys Ser Thr Leu Ile Ser Thr Ile Ser Asn145 150 155 160GCT AAG CCT AAA ATC GCT AAC TAT GAA TTT ACG ACT CTA GTG CCT AAT 589Ala Lys Pro Lys Ile Ala Asn Tyr Glu Phe Thr Thr Leu Val Pro Asn
165 170 175TTA GGG GTT GTG AGC GTG GAT GAA AAA AGC GGA TTT CTA ATG GCG GAT 637Leu Gly Val Val Ser Val Asp Glu Lys Ser Gly Phe Leu Met Ala Asp
180 185 190ATT CCT GGC ATT ATT GAA GGG GCT AGC GAG GGA AAG GGC TTA GGG ATT 685Ile Pro Gly Ile Ile Glu Gly Ala Ser Glu Gly Lys Gly Leu Gly Ile
195 200 205AGC TTT TTA AAG CAT ATT GAA CGC ACC AAA GTT CTA GCT TTT GTT TTA 733Ser Phe Leu Lys His Ile Glu Arg Thr Lys Val Leu Ala Phe Val Leu
210 215 220GAC GCT TCC AGG CTG GAT TTA GGC ATT AAA GAG CAA TAC CAA CGC TTG 781Asp Ala Ser Arg Leu Asp Leu Gly Ile Lys Glu Gln Tyr Gln Arg Leu225 230 235 240AGG TTG GAG TTG GAA AAA TTT TCA TCC GCT TTG GCC AAT AAG CCT TTT 829Arg Leu Glu Leu Glu Lys Phe Ser Ser Ala Leu Ala Asn Lys Pro Phe
245 250 255GGG GTG TTG CTC AAT AAA TGC GAT GTT GTA GAA AAC ATT GAT GAG ATG 877Gly Val Leu Leu Asn Lys Cys Asp Val Val Glu Asn Ile Asp Glu Met
260 265 270ACT AAG GAT TTT TGT GCC TTT TTA AAT TTG GGA GCG CAG AAA TTA AAC 925Thr Lys Asp Phe Cys Ala Phe Leu Asn Leu Gly Ala Gln Lys Leu Asn
275280 285GAG TTT GGT TTA GAG CCG TAT TTA GGG TTT TTG CAC CCC CAT TTA ACC 973Glu Phe Gly Leu Glu Pro Tyr Leu Gly Phe Leu His Pro His Leu Thr
290 295 300AAT GAT TTT GAA AAT AAC CCT AAT GAG CAA TCA GCG GTC TTT GTC TTG 1021Asn Asp Phe Glu Asn Asn Pro Asn Glu Gln Ser Ala Leu Phe Val Leu305 310 315 320CCC CTT TCA GCG GTT AGC GCT CTT AAT GTG CAT GCA CTC AAA TTT GTG 1069Pro Leu Ser Ala Val Ser Ala Leu Asn Val His Ala Leu Lys Phe Val
325 330 335TTG TTG GAA GCG TTA CCC TAAAACGCTA TTTTTAAAAT AATCCATTAA AATAAAGG 1125Leu Leu Glu Ala Leu Pro
340CGAGGAATGA AAAGAT 1141
(2) Sequence 1268 data:
(i) sequence characteristics:
(A) length: 342 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1268: met Val Ser Phe Arg Arg Glu Lys Phe Val Ile Lys Gly Gly Pro Asp 151015 Gly Gly Asp Gly Gly Asp Gly Gly Asp Val Tyr Phe Glu Val Asp Asn
20 25 30Asn Thr Asp Thr Leu Ala Ser Phe Arg Gly Thr Lys His His Lys Ala
35 40 45Lys Asn Gly Ala Pro Gly Gly Thr Arg Asn Cys Ala Gly Lys Lys Gly
50 55 60Glu Asp Lys Ile Ile Val Val Pro Pro Gly Thr Gln Val Phe Val Gly6570 75 80Asp Glu Leu Trp Leu Asp Leu Val Glu Pro Lys Glu Arg Val Leu Ala
85 90 95Leu Lys Gly Gly Lys Gly Gly Leu Gly Asn Ala His Phe Lys Ser Ala
100 105 110Thr Lys Gln Gln Pro Thr Tyr Ala Gln Lys Gly Leu Glu Gly Val Glu
115 120 125Lys Cys Val Arg Leu Glu Leu Lys Leu Ile Ala Asp Ile Gly Leu Val
130 135 140Gly Phe Pro Asn Ala Gly Lys Ser Thr Leu Ile Ser Thr Ile Ser Asn145 150 155 160Ala Lys Pro Lys Ile Ala Asn Tyr Glu Phe Thr Thr Leu Val Pro Asn
165 170 175Leu Gly Val Val Ser Val Asp Glu Lys Ser Gly Phe Leu Met Ala Asp
180 185 190Ile Pro Gly Ile Ile Glu Gly Ala Ser Glu Gly Lys Gly Leu Gly Ile
195 200 205Ser Phe Leu Lys His Ile Glu Arg Thr Lys Val Leu Ala Phe Val Leu
210 215 220Asp Ala Ser Arg Leu Asp Leu Gly Ile Lys Glu Gln Tyr Gln Arg Leu225 230 235 240Arg Leu Glu Leu Glu Lys Phe Ser Ser Ala Leu Ala Asn Lys Pro Phe
245 250 255Gly Val Leu Leu Asn Lys Cys Asp Val Val Glu Asn Ile Asp Glu Met
260 265 270Thr Lys Asp Phe Cys Ala Phe Leu Asn Leu Gly Ala Gln Lys Leu Asn
275 280 285Glu Phe Gly Leu Glu Pro Tyr Leu Gly Phe Leu His Pro His Leu Thr
290 295 300Asn Asp Phe Glu Asn Asn Pro Asn Glu Gln Ser Ala Leu Phe Val Leu305 310 315 320Pro Leu Ser Ala Val Ser Ala Leu Asn Val His Ala Leu Lys Phe Val
325 330 335Leu Leu Glu Ala Leu Pro
340
(2) Sequence 1269 data:
(i) sequence characteristics:
(A) length: 621bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 16...567
(D) Other information:
(xi) Description of the sequence: sequence 1269: ATTAAAGGAT AATGA ATG AAA AAA ATG GTT TTG GTA TCG GTT TTA CTA GCA 51
Met Lys Lys Met Val Leu Val Ser Val Leu Leu Ala
1 5 10GGG TTT TTG CAA GCG GTG AAT TTG GAT TTA TCT TCG GCT AAG CTA ACA 99Gly Phe Leu Gln Ala Val Asn Leu Asp Leu Ser Ser Ala Lys Leu Thr
15 20 25TGG ACA GCC TTT AAA ACT AAG GCT AAA ACA CCA GTA AAT GGG AGT TTT 147Trp Thr Ala Phe Lys Thr Lys Ala Lys Thr Pro Val Asn Gly Ser Phe
30 35 40GAA AGC ATC ACC TAT AAA TTG GGT AAA TCT CAA GAT AGT TTA AAA ACC 195Glu Ser Ile Thr Tyr Lys Leu Gly Lys Ser Gln Asp Ser Leu Lys Thr45 50 55 60CTT TTA GAG GGA GCG AGC GCG AGC ATG GAT AGC TTG AAA GTC AAT TTA 243Leu Leu Glu Gly Ala Ser Ala Ser Met Asp Ser Leu Lys Val Asn Leu
65 70 75GGC GAT GAA TTG AAA AAC AAA AAT GTG AAA GAA GCT TTT TTC GCT CTT 291Gly Asp Glu Leu Lys Asn Lys Asn Val Lys Glu Ala Phe Phe Ala Leu
80 85 90TTT AAA AAC ACT AAC ATC AAA GTA ACT TTC AGG AAT GTG ATA GAA GGC 339Phe Lys Asn Thr Asn Ile Lys Val Thr Phe Arg Asn Val Ile Glu Gly
95 100 105GAT CAT GCA GGT TCT CTT ACG GCT TAT GTG AGA ATG AAT GAA AAG CTG 387Asp His Ala Gly Ser Leu Thr Ala Tyr Val Arg Met Asn Glu Lys Leu
110 115 120GTG AAA GTG CCT ATG CAA TAC ACG ATT GCT GAG GAT AAG ATC GTG GTT 435Val Lys Val Pro Met Gln Tyr Thr Ile Ala Glu Asp Lys Ile Val Val125 130 135 140AAA GGG GTT TTG GAT TTA TTG AAT TTT GGC TTG AAA AAC GAA TTA GCG 483Lys Gly Val Leu Asp Leu Leu Asn Phe Gly Leu Lys Asn Glu Leu Ala
145 150 155AGC TTG GCC AAA CGA TGC GAA AGC TTT CAT GAG GGC TTG ACT TGG TCG 531Ser Leu Ala Lys Arg Cys Glu Ser Phe His Glu Gly Leu Thr Trp Ser
160 165 170CAA GTG GAA ATC CAA TTT GAA AGC ATG ATC AAG GGA TAATGTAAAA TCATGG 583Gln Val Glu Ile Gln Phe Glu Ser Met Ile Lys Gly
175 180AGTTGTTGCA CAGCATTAAT GATTTCAATG AAGCTAAG 621
(2) Sequence 1270 data:
(i) sequence characteristics:
(A) length: 184 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1270: met Lys Lys Met Val Leu Val Ser Val Leu Leu Ala Gly Phe Leu Gln 151015 Ala Val Asn Leu Asp Leu Ser Ser Ala Lys Leu Thr Trp Thr Ala Phe
20 25 30Lys Thr Lys Ala Lys Thr Pro Val Asn Gly Ser Phe Glu Ser Ile Thr
35 40 45Tyr Lys Leu Gly Lys Ser Gln Asp Ser Leu Lys Thr Leu Leu Glu Gly
50 55 60Ala Ser Ala Ser Met Asp Ser Leu Lys Val Asn Leu Gly Asp Glu Leu65 70 75 80Lys Asn Lys Asn Val Lys Glu Ala Phe Phe Ala Leu Phe Lys Asn Thr
85 90 95Asn Ile Lys Val Thr Phe Arg Asn Val Ile Glu Gly Asp His Ala Gly
100 105 110Ser Leu Thr Ala Tyr Val Arg Met Asn Glu Lys Leu Val Lys Val Pro
115 120 125Met Gln Tyr Thr Ile Ala Glu Asp Lys Ile Val Val Lys Gly Val Leu
130 135 140Asp Leu Leu Asn Phe Gly Leu Lys Asn Glu Leu Ala Ser Leu Ala Lys145 150 155 160Arg Cys Glu Ser Phe His Glu Gly Leu Thr Trp Ser Gln Val Glu Ile
165 170 175Gln Phe Glu Ser Met Ile Lys Gly
180
(2) Sequence 1271 data:
(i) sequence characteristics:
(A) length: 1406bp by 1406bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 49...1338
(D) Other information:
(xi) Description of the sequence: sequence 1271: CAAGTGGAAA TCCAATTTGA AAGCATGATC AAGGGATAAT GTAAAATC ATG GAG TTG 57
Met Glu Leu
1TTG CAC AGC ATT AAT GAT TTC AAT GAA GCT AAG CAG GTG ATC GCT GGG 105Leu His Ser Ile Asn Asp Phe Asn Glu Ala Lys Gln Val Ile Ala Gly
5 10 15GGG GTC AAT TCA CCT GTT AGG GCG TTT AAG AGC GTT AAA GGC ACT CCC 153Gly Val Asn Ser Pro Val Arg Ala Phe Lys Ser Val Lys Gly Thr Pro20 25 30 35CCC TTT ATT TTA AAA GGC AAG GGG GCG TAT CTT TAT GAT GTG GAT AAC 201Pro Phe Ile Leu Lys Gly Lys Gly Ala Tyr Leu Tyr Asp Val Asp Asn
40 45 50AAC CAT TAT ATA GAT TTT GTG CAA AGC TGG GGG CCT TTG ATT TTT GGG 249Asn His Tyr Ile Asp Phe Val Gln Ser Trp Gly Pro Leu Ile Phe Gly
55 60 65CAT GCT GAT GAA GAG ATT GAA GAA AAT ATT ATT AAT GCA TTA AAA AAA 297His Ala Asp Glu Glu Ile Glu Glu Asn Ile Ile Asn Ala Leu Lys Lys
70 75 80GGC ACT TCT TTT GGC GCT CCC ACA GAA TTA GAA ACC ACT TTA GCT AAG 345Gly Thr Ser Phe Gly Ala Pro Thr Glu Leu Glu Thr Thr Leu Ala Lys
85 90 95GAA ATC ATT TCT TGT TAT GAA GGC TTA GAT AAG GTG CGT TTA GTC AGT 393Glu Ile Ile Ser Cys Tyr Glu Gly Leu Asp Lys Val Arg Leu Val Ser100 105 110 115AGC GGC ACA GAA GCG ACC ATG AGC GCG ATA CGA CTC GCT AGA GCT TAT 441Ser Gly Thr Glu Ala Thr Met Ser Ala Ile Arg Leu Ala Arg Ala Tyr
120 125 130AGC CAA AAA GAT GAT TTG ATC AAG TTT GAA GGG TGC TAC CAT GGG CAT 489Ser Gln Lys Asp Asp Leu Ile Lys Phe Glu Gly Cys Tyr His Gly His
135 140 145AGC GAC TCC TTA TTG GTG AAA GCG GGT AGC GGG TGT GCT ACT TTT GGA 537Ser Asp Ser Leu Leu Val Lys Ala Gly Ser Gly Cys Ala Thr Phe Gly
150 155 160TCG CCT TCT TCT TTA GGC GTG CCG AAC GAT ITT AGC AAA CAC ACT CTA 585Ser Pro Ser Ser Leu Gly Val Pro Asn Asp Phe Ser Lys His Thr Leu
165 170 175GTG GCT CGT TAT AAC GAT TTA AAC TCC ACA GAA GAA TGC TTT AAA AAA 633Val Ala Arg Tyr Asn Asp Leu Asn Ser Thr Glu Glu Cys Phe Lys Lys180 185 190 195GGC AAT GTG GGT TGC GTC ATC ATT GAA CCC ATT GCC GGG AAT ATG GGG 681Gly Asn Val Gly Cys Val Ile Ile Glu Pro Ile Ala Gly Asn Met Gly
200 205 210TTA GTG CCG GCT CAA AAA GAG TTT TTA TTG GGC TTA AAG GCC TTG TGT 729Leu Val Pro Ala Gln Lys Glu Phe Leu Leu Gly Leu Lys Ala Leu Cys
215 220 225GAA AAA TAC CAA GCG GTG CTG ATT TTA GAT GAA GTG ATG AGC GGT TTT 777Glu Lys Tyr Gln Ala Val Leu Ile Leu Asp Glu Val Met Ser Gly Phe
230 235 240AGA GCG AGC TTG AGC GGT TCG CAA GAA TTT TAT GGC GTG GTG CCG GAT 825Arg Ala Ser Leu Ser Gly Ser Gln Glu Phe Tyr Gly Val Val Pro Asp
245 250 255TTG GTA ACC TTT GGT AAG GTG ATA GGT GCT GGG CTT CCT TTG GCG TGT 873Leu Val Thr Phe Gly Lys Val Ile Gly Ala Gly Leu Pro Leu Ala Cys260 265 270 275TTT GGA GGG CGT GCA GAA ATT ATG GAC TTG CTT TCG CCC ATT GGA AGC 921Phe Gly Gly Arg Ala Glu Ile Met Asp Leu Leu Ser Pro Ile Gly Ser
280 285 290GTG TAT CAA GCA GGC ACT TTG AGC GGT AAC CCC CTA GCG GTG TGC GCG 969Val Tyr Gln Ala Gly Thr Leu Ser Gly Asn Pro Leu Ala Val Cys Ala
295 300 305GGG TTG AGT GCG CTT TAT AAA ATC AAA AGA GAC AAA ACC CTT TAT ACT 1017Gly Leu Ser Ala Leu Tyr Lys Ile Lys Arg Asp Lys Thr Leu Tyr Thr
310 315 320CGC TTA GAC GCT TTA GCT ATT CGT TTG ACT CAA GGC TTA CAA AAG AGC 1065Arg Leu Asp Ala Leu Ala Ile Arg Leu Thr Gln Gly Leu Gln Lys Ser
325 330 335GCT CAA AAC TAT AAC ATC GCT TTA GAG ACG CTT AAC ATG GGG AGC ATG 1113Ala Gln Asn Tyr Asn Ile Ala Leu Glu Thr Leu Asn Met Gly Ser Met340 345 350 355TTT GGC TTT TTC TTT AAC GAA AAT GCG GTG CAC GAT TTT GAT GAC GCT 1161Phe Gly Phe Phe Phe Asn Glu Asn Ala Val His Asp Phe Asp Asp Ala
360 365 370TTA AAA AGC GAT ACG GAG ATG TTT GCA AAA TTC CAC CAA AAA ATG CTC 1209Leu Lys SerAsp Thr Glu Met Phe Ala Lys Phe His Gln Lys Met Leu
375 380 385TTT AAG GGC GTG TAT TTG GCG TGC TCA AGC TTT GAA ACC GGC TTT ATT 1257Phe Lys Gly Val Tyr Leu Ala Cys Ser Ser Phe Glu Thr Gly Phe Ile
390 395 400TGT GAG CCT ATG ACT GAA GAG ATG ATT GAT TTA ACG ATC GCA AAA GCC 1305Cys Glu Pro Met Thr Glu Glu Met Ile Asp Leu Thr Ile Ala Lys Ala
405 410 415GAT GAA AGT TTT GAT GAA ATC ATA AAA GGT GTG TGAATTTTTT GAAAAAGCCA 1358Asp Glu Ser Phe Asp Glu Ile Ile Lys Gly Val420 425 430AAGTATTATA AATTCATAGA GGGGGCGAAT TATTTGAGCT TGGGGCTT 1406
(2) Sequence 1272 data:
(i) sequence characteristics:
(A) length: 430 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1272: met Glu Leu Leu His Ser Ile Asn Asp Phe Asn Glu Ala Lys Gln Val 151015 Ile Ala Gly Gly Val Asn Ser Pro Val Arg Ala Phe Lys Ser Val Lys
20 25 30Gly Thr Pro Pro Phe Ile Leu Lys Gly Lys Gly Ala Tyr Leu Tyr Asp
35 40 45Val Asp Asn Asn His Tyr Ile Asp Phe Val Gln Ser Trp Gly Pro Leu
50 55 60Ile Phe Gly His Ala Asp Glu Glu Ile Glu Glu Asn Ile Ile Asn Ala65 70 75 80Leu Lys Lys Gly Thr Ser Phe Gly Ala Pro Thr GluLeu Glu Thr Thr
85 90 95Leu Ala Lys Glu Ile Ile Ser Cys Tyr Glu Gly Leu Asp Lys Val Arg
100 105 110Leu Val Ser Ser Gly Thr Glu Ala Thr Met Ser Ala Ile Arg Leu Ala
115 120 125Arg Ala Tyr Ser Gln Lys Asp Asp Leu Ile Lys Phe Glu Gly Cys Tyr
130 135 140His Gly His Ser Asp Ser Leu Leu Val Lys Ala Gly Ser Gly Cys Ala145 150 155 160Thr Phe Gly Ser Pro Ser Ser Leu Gly Val Pro Asn Asp Phe Ser Lys
165 170 175His Thr Leu Val Ala Arg Tyr Asn Asp Leu Asn Ser Thr Glu Glu Cys
180 185 190Phe Lys Lys Gly Asn Val Gly Cys Val Ile Ile Glu Pro Ile Ala Gly
195 200 205Asn Met Gly Leu Val Pro Ala Gln Lys Glu Phe Leu Leu Gly Leu Lys
210 215 220Ala Leu Cys Glu Lys Tyr Gln Ala Val Leu Ile Leu Asp Glu Val Met225 230 235 240Ser Gly Phe Arg Ala Ser Leu Ser Gly Ser Gln Glu Phe Tyr Gly Val
245 250 255Val Pro Asp Leu Val Thr Phe Gly Lys Val Ile Gly Ala Gly Leu Pro
260 265 270Leu Ala Cys Phe Gly Gly Arg Ala Glu Ile Met Asp Leu Leu Ser Pro
275 280 285Ile Gly Ser Val Tyr Gln Ala Gly Thr Leu Ser Gly Asn Pro Leu Ala
290 295 300Val Cys AlaGly Leu Ser Ala Leu Tyr Lys Ile Lys Arg Asp Lys Thr305 310 315 320Leu Tyr Thr Arg Leu Asp Ala Leu Ala Ile Arg Leu Thr Gln Gly Leu
325 330 335Gln Lys Ser Ala Gln Asn Tyr Asn Ile Ala Leu Glu Thr Leu Asn Met
340 345 350Gly Ser Met Phe Gly Phe Phe Phe Asn Glu Asn Ala Val His Asp Phe
355 360 365Asp Asp Ala Leu Lys Ser Asp Thr Glu Met Phe Ala Lys Phe His Gln
370 375 380Lys Met Leu Phe Lys Gly Val Tyr Leu Ala Cys Ser Ser Phe Glu Thr385 390 395 400Gly Phe Ile Cys Glu Pro Met Thr Glu Glu Met Ile Asp Leu Thr Ile
405 410 415Ala Lys Ala Asp Glu Ser Phe Asp Glu Ile Ile Lys Gly Val
420 425 430
(2) Sequence 1273 data:
(i) sequence characteristics:
(A) length: 1100bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 90...1052
(D) Other information:
(xi) Description of the sequence: sequence 1273: AAGGCGCAAA ACTTAGCCAA AAAAGAGATG GACGCACTAG ATTCTCATCT GTTAGCGTTT 60TTAAATCAAA ATGCAAATGC CATTCACTG ATG CCC AAA ATC CCT ATC ACG CTC 113
Met Pro Lys Ile Pro Ile Thr Leu
1 5ATC ACC GGT TTT TTA GGC AGC GGT AAA ACG AGT TTT TTG AGC GAA TAT 161Ile Thr Gly Phe Leu Gly Ser Gly Lys Thr Ser Phe Leu Ser Glu Tyr
10 15 20TTA AAC CAA ACA GAT CAC CAA GGC GTC GCT CTT ATC ATC AAT GAA ATC 209Leu Asn Gln Thr Asp His Gln Gly Val Ala Leu Ile Ile Asn Glu Ile25 30 35 40GGT CAA GCC GCT TTG GAT CAG CGC ATC TTA AGC GTT CAA TAT TGC GGT 257Gly Gln Ala Ala Leu Asp Gln Arg Ile Leu Ser Val Gln Tyr Cys Gly
45 50 55GAA AAA ATG CTC TAT CTT AAC GCA GGG TGC GTG TGT TGC AAC AAA CGC 305Glu Lys Met Leu Tyr Leu Asn Ala Gly Cys Val Cys Cys Asn Lys Arg
60 65 70TTG GAT TTA GTG GAG TCT CTA AAA GCC ACG CTC AAC AAC TAT GAA TGG 353Leu Asp Leu Val Glu Ser Leu Lys Ala Thr Leu Asn Asn Tyr Glu Trp
75 80 85CAC GGC GAA ATT CTA AGG CGC ATC ATC ATT GAA ACT ACC GGT TTA GCC 401His Gly Glu Ile Leu Arg Arg Ile Ile Ile Glu Thr Thr Gly Leu Ala
90 95 100AAC CCG GCA CCG ATT TTA TGG ACG ATT TTG AGC GAC ACT TTT TTA GGA 449Asn Pro Ala Pro Ile Leu Trp Thr Ile Leu Ser Asp Thr Phe Leu Gly105 110 115 120GTG CAT TTT GAG ATT CAA AGC GTG GTG GCT TGC GTG GAT GCA TTG AAT 497Val His Phe Glu Ile Gln Ser Val Val Ala Cys Val Asp Ala Leu Asn
125 130 135GCT AGA GAG CAT TTA ACC AAC AAT GAA GCT AAA GAG CAA ATC GTT TTT 545Ala Arg Glu His LeuThr Asn Asn Glu Ala Lys Glu Gln Ile Val Phe
140 145 150GCT GAT AGC GTT TTA TTG ACC AAA ACG GAT TTA CAA AAC GAT AGC GCG 593Ala Asp Ser Val Leu Leu Thr Lys Thr Asp Leu Gln Asn Asp Ser Ala
155 160 165GCT TTA ACA AAA CTA AAA GAG AGG ATA CAA GCC CTT AAC CCT AGT GCA 641Ala Leu Thr Lys Leu Lys Glu Arg Ile Gln Ala Leu Asn Pro Ser Ala
170 175 180GAA ATT TTT GAC AAG AGG GCG ATA GAC TAT GAG AGC CTC TTT TCA CGC 689Glu Ile Phe Asp Lys Arg Ala Ile Asp Tyr Glu Ser Leu Phe Ser Arg185 190 195 200AAA AAT AGG GCG CGA AAT TTT ATG CCA AGA ATG CCA AAA GAT TCG CAC 737Lys Asn Arg Ala Arg Asn Phe Met Pro Arg Met Pro Lys Asp Ser His
205 210 215TCG CAA GGC TTT GAG ACT TTA AGC ATT AAT TTT GAA GGC ACG ATG GAG 785Ser Gln Gly Phe Glu Thr Leu Ser Ile Asn Phe Glu Gly Thr Met Glu
220 225 230TGG AGC GCG TTT GGG ATT TGG CTG AGT TTG TTA TTG CAT CAA TAC GGC 833Trp Ser Ala Phe Gly Ile Trp Leu Ser Leu Leu Leu His Gln Tyr Gly
235 240 245ACA CAG ATT TTA CGC ATC AAG GGG ATT ATT GAC ATT GGA AGC GGC TTT 881Thr Gln Ile Leu Arg Ile Lys Gly Ile Ile Asp Ile Gly Ser Gly Phe
250 255 260TTG GTG AGT ATT AAC GGC GTG ATG CAT GTC ATT TAC CCG CCT AAG CAT 929Leu Val Ser Ile Asn Gly Val Met His Val Ile Tyr Pro Pro Lys His265 270 275 280ATT TTA AAG GAT CAA AAC GGC TCT AAC CTC GTT TTT ATC ATG CGC CAT 977Ile Leu Lys Asp Gln Asn Gly Ser Asn Leu Val Phe Ile Met Arg His
285 290 295TTA GAG CGT GAA AAA ATC TTA AAT TCC TTA AAG GGT TTT AAG GAT TTT 1025Leu Glu Arg Glu Lys Ile Leu Asn Ser Leu Lys Gly Phe Lys Asp Phe
300 305 310CTC GGC ATC AAG GGT TTT GAA ACC CAA TAATTTTTCT ATTTATGGAT AGCTGTT 1079Leu Gly Ile Lys Gly Phe Glu Thr Gln
315 320TGCATTTTGA TGGGGAAAAG A 1100
(2) Sequence 1274 data:
(i) sequence characteristics:
(A) length: 321 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1274: met Pro Lys Ile Pro Ile Thr Leu Ile Thr Gly Phe Leu Gly Ser Gly 151015 Lys Thr Ser Phe Leu Ser Glu Tyr Leu Asn Gln Thr Asp His Gln Gly
20 25 30Val Ala Leu Ile Ile Asn Glu Ile Gly Gln Ala Ala Leu Asp Gln Arg
35 40 45Ile Leu Ser Val Gln Tyr Cys Gly Glu Lys Met Leu Tyr Leu Asn Ala
50 55 60Gly Cys Val Cys Cys Asn Lys Arg Leu Asp Leu Val Glu Ser Leu Lys65 70 75 80Ala Thr Leu Asn Asn Tyr Glu Trp His Gly Glu Ile Leu Arg Arg Ile
85 90 95Ile Ile Glu Thr Thr Gly Leu Ala Asn Pro Ala Pro Ile Leu Trp Thr
100 105 110Ile Leu SerAsp Thr Phe Leu Gly Val His Phe Glu Ile Gln Ser Val
115 120 125Val Ala Cys Val Asp Ala Leu Asn Ala Arg Glu His Leu Thr Asn Asn
130 135 140Glu Ala Lys Glu Gln Ile Val Phe Ala Asp Ser Val Leu Leu Thr Lys145 150 155 160Thr Asp Leu Gln Asn Asp Ser Ala Ala Leu Thr Lys Leu Lys Glu Arg
165 170 175Ile Gln Ala Leu Asn Pro Ser Ala Glu Ile Phe Asp Lys Arg Ala Ile
180 185 190Asp Tyr Glu Ser Leu Phe Ser Arg Lys Asn Arg Ala Arg Asn Phe Met
195 200 205Pro Arg Met Pro Lys Asp Ser His Ser Gln Gly Phe Glu Thr Leu Ser
210 215 220Ile Asn Phe Glu Gly Thr Met Glu Trp Ser Ala Phe Gly Ile Trp Leu225 230 235 240Ser Leu Leu Leu His Gln Tyr Gly Thr Gln Ile Leu Arg Ile Lys Gly
245 250 255Ile Ile Asp Ile Gly Ser Gly Phe Leu Val Ser Ile Asn Gly Val Met
260 265 270His Val Ile Tyr Pro Pro Lys His Ile Leu Lys Asp Gln Asn Gly Ser
275 280 285Asn Leu Val Phe Ile Met Arg His Leu Glu Arg Glu Lys Ile Leu Asn
290 295 300Ser Leu Lys Gly Phe Lys Asp Phe Leu Gly Ile Lys Gly Phe Glu Thr305 310 315 320Gln
(2) Sequence 1275 data:
(i) sequence characteristics:
(A) length: 1713bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 26...1648
(D) Other information:
(xi) Description of the sequence: sequence 1275: TTAAAAGCAA ACAAGAAAGT TAAGC ATG CAC ACT CTC ATT AAG GGC ATT TTA 52
Met His Thr Leu Ile Lys Gly Ile Leu
1 5GAA GAG ATT TTA GAA GAA GAA GTC ATT GTT GAA TAC CCT AAA GAC AGA 100Glu Glu Ile Leu Glu Glu Glu Val Ile Val Glu Tyr Pro Lys Asp Arg10 15 20 25GAG CAT GGG CAT TAC GCT ACG CCC ATT GCT TTC AAT CTC GCC AAA GTT 148Glu His Gly His Tyr Ala Thr Pro Ile Ala Phe Asn Leu Ala Lys Val
30 35 40TTT AAA AAA TCG CCC TTA GCC ATC GCT GAA GAG TTA GCC CTT AAA ATC 196Phe Lys Lys Ser Pro Leu Ala Ile Ala Glu Glu Leu Ala Leu Lys Ile
45 50 55AGC ACG CAT GAA AAA ACT CAA GGG CTT TTT GAC AGC GTA GTG GCT TGT 244Ser Thr His Glu Lys Thr Gln Gly Leu Phe Asp Ser Val Val Ala Cys
60 65 70AAG GGC TAT ATC AAT TTC ACG CTT TCT TTA GAT TTT TTG GAG CGT TTC 292Lys Gly Tyr Ile Asn Phe Thr Leu Ser Leu Asp Phe Leu Glu Arg Phe
75 80 85ACC CAA AAA GCT TTG GAA TTG AAA GAA AAA TTT GGCTCT CAA GTT AAA 340Thr Gln Lys Ala Leu Glu Leu Lys Glu Lys Phe Gly Ser Gln Val Lys90 95 100 105AGC GAA CGT TCT CAA AAA ATC TTT TTA GAA TTT GTG AGC GCT AAC CCC 388Ser Glu Arg Ser Gln Lys Ile Phe Leu Glu Phe Val Ser Ala Asn Pro
110 115 120ACA GGG CCT TTA CAC ATA GGG CAT GCT AGA GGG GCG GTG TTT GGC GAT 436Thr Gly Pro Leu His Ile Gly His Ala Arg Gly Ala Val Phe Gly Asp
125 130 135AGT TTG GCT AAA ATC GCT CGC TTT TTA GGG CAT GAA GTT TTA TGC GAG 484Ser Leu Ala Lys Ile Ala Arg Phe Leu Gly His Glu Val Leu Cys Glu
140 145 150TAT TAT GTC AAT GAC ATG GGA TCT CAA ATC CGC TTG TTA GGG CTT TCT 532Tyr Tyr Val Asn Asp Met Gly Ser Gln Ile Arg Leu Leu Gly Leu Ser
155 160 165GTA TGG CTC GCT TAC AGA GAA CAT GTT TTA AAA GAA AGC GTA ACT TAC 580Val Trp Leu Ala Tyr Arg Glu His Val Leu Lys Glu Ser Val Thr Tyr170 175 180 185CCA GAA GTC TTT TAC AAA GGC GAA TAC ATC ATT GAA ATC GCT AAA AAG 628Pro Glu Val Phe Tyr Lys Gly Glu Tyr Ile Ile Glu Ile Ala Lys Lys
190 195 200GCG AAC AAC GAT TTA GAA CCA AGC CTT TTA AAA GAA AAC GAA GAA ACG 676Ala Asn Asn Asp Leu Glu Pro Ser Leu Leu Lys Glu Asn Glu Glu Thr
205 210 215ATT ATT GAA GTT TTA AGC GGC TAT GCT AGG GAT CTA ATG CTT TTA GAA 724Ile Ile Glu Val Leu Ser Gly Tyr Ala Arg Asp Leu Met Leu Leu Glu
220 225 230ATT AAA GAT AAT TTA GAC GCT TTA GGC ATT CAT TTT GAT TCC TAT GCG 772Ile Lys Asp Asn Leu Asp Ala Leu Gly Ile HisPhe Asp Ser Tyr Ala
235 240 245AGC GAA AAA GAA GTT TTT AAA CAT AAA GAT GCG GTG TTT GAA CAA TTA 820Ser Glu Lys Glu Val Phe Lys His Lys Asp Ala Val Phe Glu Gln Leu250 255 260 265GAA AAA GCG AAC GCC CTT TAT GAA AAG GAT TCT AAA ATC TGG CTC AAA 868Glu Lys Ala Asn Ala Leu Tyr Glu Lys Asp Ser Lys Ile Trp Leu Lys
270 275 280TCT TCA CTC TAC CAG GAT GAA AGC GAT CGG GTG CTC ATT AAA GAA GAT 916Ser Ser Leu Tyr Gln Asp Glu Ser Asp Arg Val Leu Ile Lys Glu Asp
285 290 295AAA AGC TAC ACT TAT TTA GCG GGC GAT ATT GTC TAT CAT GAT GAA AAA 964Lys Ser Tyr Thr Tyr Leu Ala Gly Asp Ile Val Tyr His Asp Glu Lys
300 305 310TTC AAG CAA GAT TAT ACC AAA TAC ATC AAC ATT TGG GGG GCA GAC CAC 1012Phe Lys Gln Asp Tyr Thr Lys Tyr Ile Asn Ile Trp Gly Ala Asp His
315 320 325CAC GGC TAT ATC GCT AGA GTG AAA GCC AGC CTT GAG TTT TTG GGC TAT 1060His Gly Tyr Ile Ala Arg Val Lys Ala Ser Leu Glu Phe Leu Gly Tyr330 335 340 345GAT TCC AAC AAG CTT GAA GTC TTG CTC GCT CAA ATG GTG CGC TTG CTC 1108Asp Ser Asn Lys Leu Glu Val Leu Leu Ala Gln Met Val Arg Leu Leu
350 355 360AAA GAT AAC GAG CCT TAC AAG ATG AGT AAA AGA GCG GGT AAT TTT ATT 1156Lys Asp Asn Glu Pro Tyr Lys Met Ser Lys Arg Ala Gly Asn Phe Ile
365 370 375TTG ATT AAA GAT GTG GTT GAT GAT GTG GGT AAG GAC GCT TTG AGG TTT 1204Leu Ile Lys Asp Val Val Asp Asp Val Gly Lys Asp Ala Leu Arg Phe
380 385 390ATT TTT TTG AGC AAA CGG CTT GAC ACT CAT TTA GAA TTT GAT GTC AAT 1252Ile Phe Leu Ser Lys Arg Leu Asp Thr His Leu Glu Phe Asp Val Asn
395 400 405ACT TTA AAA AAG CAA GAC AGC TCA AAC CCC ATT TAC TAT ATC CAT TAC 1300Thr Leu Lys Lys Gln Asp Ser Ser Asn Pro Ile Tyr Tyr Ile His Tyr410 415 420 425GCT AAT TCG CGC ATC CAC ACC ATG CTA GAA AAA TCG CCC TTT TCT AAA 1348Ala Asn Ser Arg Ile His Thr Met Leu Glu Lys Ser Pro Phe Ser Lys
430 435 440GAA GAG GTT TTG CAA ACC CCT TTA ACC AAT TTA AAC GCT GAA GAA AAA 1396Glu Glu Val Leu Gln Thr Pro Leu Thr Asn Leu Asn Ala Glu Glu Lys
445 450 455TAC TTG CTT TTT AGC GCT TTA AGC TTG CCT AAA GCA ATT GAA TCC TCT 1444Tyr Leu Leu Phe Ser Ala Leu Ser Leu Pro Lys Ala Ile Glu Ser Ser
460 465 470TTT GAA GAA TAC GGC TTG CAA AAA ATG TGC GAA TAC GCA AAA ACC CTC 1492Phe Glu Glu Tyr Gly Leu Gln Lys Met Cys Glu Tyr Ala Lys Thr Leu
475 480 485GCA TCA GAA TTC CAC CGC TTC TAT AAC GCT GGC AAA ATC TTA GAC ACC 1540Ala Ser Glu Phe His Arg Phe Tyr Asn Ala Gly Lys Ile Leu Asp Thr490 495 500 505CCT AAA GCT AAA GAG CTT TTA AAA ATT TGT TTA ATA GTA AGC TTG AGC 1588Pro Lys Ala Lys Glu Leu Leu Lys Ile Cys Leu Ile Val Ser Leu Ser
510 515 520TTA AGC AAC GCT TTT AAA CTT TTA GGC ATA GAG ATA AAG ACC AAA ATT 1636Leu Ser Asn Ala Phe Lys Leu Leu Gly Ile Glu Ile Lys Thr Lys Ile
525 530 535TCC GCT AGA GAT TAAGCCAATA TTTAATTTTT TGTTATAACA TTCCCCTTAT TTTTT 1693Ser Ala Arg Asp
540GAAACTAAGG AGAATATTAT 1713
(2) Sequence 1276 data:
(i) sequence characteristics:
(A) length: 541 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1276: met His Thr Leu Ile Lys Gly Ile Leu Glu Glu Ile Leu Glu Glu Glu 151015 Val Ile Val Glu Tyr Pro Lys Asp Arg Glu His Gly His Tyr Ala Thr
20 25 30Pro Ile Ala Phe Asn Leu Ala Lys Val Phe Lys Lys Ser Pro Leu Ala
35 40 45Ile Ala Glu Glu Leu Ala Leu Lys Ile Ser Thr His Glu Lys Thr Gln
50 55 60Gly Leu Phe Asp Ser Val Val Ala Cys Lys Gly Tyr Ile Asn Phe Thr65 70 75 80Leu Ser Leu Asp Phe Leu Glu Arg Phe Thr Gln Lys Ala Leu Glu Leu
85 90 95Lys Glu Lys Phe Gly Ser Gln Val Lys Ser Glu Arg Ser Gln Lys Ile
100 105 110Phe Leu Glu Phe Val Ser Ala Asn Pro Thr Gly Pro Leu His Ile Gly
115 120 125His Ala Arg Gly Ala Val Phe Gly Asp Ser Leu Ala Lys Ile Ala Arg
130 135 140Phe Leu Gly His Glu Val Leu Cys Glu Tyr Tyr Val Asn Asp Met Gly145 150 155 160Ser Gln Ile Arg Leu Leu Gly Leu Ser Val Trp Leu Ala Tyr Arg Glu
165 170 175His Val Leu Lys Glu Ser Val Thr Tyr Pro Glu Val Phe Tyr Lys Gly
180 185 190Glu Tyr Ile Ile Glu Ile Ala Lys Lys Ala Asn Asn Asp Leu Glu Pro
195 200 205Ser Leu Leu Lys Glu Asn Glu Glu Thr Ile Ile Glu Val Leu Ser Gly
210 215 220Tyr Ala Arg Asp Leu Met Leu Leu Glu Ile Lys Asp Asn Leu Asp Ala225 230 235 240Leu Gly Ile His Phe Asp Ser Tyr Ala Ser Glu Lys Glu Val Phe Lys
245 250 255His Lys Asp Ala Val Phe Glu Gln Leu Glu Lys Ala Asn Ala Leu Tyr
260 265 270Glu Lys Asp Ser Lys Ile Trp Leu Lys Ser Ser Leu Tyr Gln Asp Glu
275 280 285Ser Asp Arg Val Leu Ile Lys Glu Asp Lys Ser Tyr Thr Tyr Leu Ala
290 295 300Gly Asp Ile Val Tyr His Asp Glu Lys Phe Lys Gln Asp Tyr Thr Lys305 310 315 320Tyr Ile Asn Ile Trp Gly Ala Asp His His Gly Tyr Ile Ala Arg Val
325 330 335Lys Ala Ser Leu Glu Phe Leu Gly Tyr Asp Ser Asn Lys Leu Glu Val
340 345 350Leu Leu Ala Gln Met Val Arg Leu Leu Lys Asp Asn Glu Pro Tyr Lys
355 360 365Met Ser Lys Arg Ala Gly Asn Phe Ile Leu Ile Lys Asp Val Val Asp
370 375 380Asp Val Gly Lys Asp Ala Leu Arg Phe Ile Phe Leu Ser Lys Arg Leu385 390 395 400Asp Thr His Leu Glu Phe Asp Val Asn Thr Leu Lys Lys Gln Asp Ser
405 410 415Ser Asn Pro Ile Tyr Tyr Ile His Tyr Ala Asn Ser Arg Ile His Thr
420 425 430Met Leu Glu Lys Ser Pro Phe Ser Lys Glu Glu Val Leu Gln Thr Pro
435 440 445Leu Thr Asn Leu Asn Ala Glu Glu Lys Tyr Leu Leu Phe Ser Ala Leu
450 455 460Ser Leu Pro Lys Ala Ile Glu Ser Ser Phe Glu Glu Tyr Gly Leu Gln465 470 475 480Lys Met Cys Glu Tyr Ala Lys Thr Leu Ala Ser Glu Phe His Arg Phe
485 490 495Tyr Asn Ala Gly Lys Ile Leu Asp Thr Pro Lys Ala Lys Glu Leu Leu
500 505 510Lys Ile Cys Leu Ile Val Ser Leu Ser Leu Ser Asn Ala Phe Lys Leu
515 520 525Leu Gly Ile Glu Ile Lys Thr Lys Ile Ser Ala Arg Asp
530 535 540
(2) Sequence 1277 data:
(i) sequence characteristics:
(A) length: 896bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 38...835
(D) Other information:
(xi) Description of the sequence: sequence 1277: AAGTAGAGAT TATATTACCT AGATAGTGAA TCAACGA ATG AAA AGC CAC TTC CAA 55
Met Lys Ser His Phe Gln
1 5TAC AGC ACG CTA GAA AAT ATC CCT AAA GCC TTT GAC ATT CTC AAA GAC 103Tyr Ser Thr Leu Glu Asn Ile Pro Lys Ala Phe Asp Ile Leu Lys Asp
10 15 20CCC CCT AAA AAA CTC TAT TGT GTG GGC GAT ACC AAG CTT TTG GAC ACG 151Pro Pro Lys Lys Leu Tyr Cys Val Gly Asp Thr Lys Leu Leu Asp Thr
25 30 35CCT TTA AAA GTG GCG ATC ATA GGC ACA AGA AGA CCC ACC CCT TAC AGC 199Pro Leu Lys Val Ala Ile Ile Gly Thr Arg Arg Pro Thr Pro Tyr Ser
40 45 50AAG CAA CAC ACG ATC ACT CTA GCT AGA GAG CTT GCT AAA AAT GGC GCG 247Lys Gln His Thr Ile Thr Leu Ala Arg Glu Leu Ala Lys Asn Gly Ala55 60 65 70GTT ATT GTG AGT GGG GGA GCG TTA GGC GTG GAT ATT ATC GCT CAA GAA 295Val Ile Val Ser Gly Gly Ala Leu Gly Val Asp Ile Ile Ala Gln Glu
75 80 85AAC GCC TTG CCA AAA ACG ATC ATG CTT TCG CCT TGC AGT TTG GAT TTC 343Asn Ala Leu Pro Lys Thr Ile Met Leu Ser Pro Cys Ser Leu Asp Phe
90 95 100ATC TAT CCT ACG AAC AAT CAT AAA GTG ATC CAA GAA ATC GCG CAA AAC 391Ile Tyr Pro Thr Asn Asn His Lys Val Ile Gln Glu Ile Ala Gln Asn
105 110115GGC TTG ATT TTA AGC GAA TAT GAA AAG GAT TTC ATG CCC ATT AAA GGC 439Gly Leu Ile Leu Ser Glu Tyr Glu Lys Asp Phe Met Pro Ile Lys Gly
120 125 130TCT TTT TTG GCG AGA AAC CGC CTG GTG ATC GCT TTA AGC GAT GTG GTG 487Ser Phe Leu Ala Arg Asn Arg Leu Val Ile Ala Leu Ser Asp Val Val135 140 145 150ATT ATC CCC CAA GCG GAT TTA AAA AGC GGC TCT ATG AGC AGC GCG AGA 535Ile Ile Pro Gln Ala Asp Leu Lys Ser Gly Ser Met Ser Ser Ala Arg
155 160 165TTA GCC CAG AAA TAC CAA AAG CCT TTA TTT GTT TTA CCC CAA CGC CTG 583Leu Ala Gln Lys Tyr Gln Lys Pro Leu Phe Val Leu Pro Gln Arg Leu
170 175 180AAT GAG AGC GAT GGC ACT AAT GAG CTT TTA GAA AAA GGG CAG GCT CAA 631Asn Glu Ser Asp Gly Thr Asn Glu Leu Leu Glu Lys Gly Gln Ala Gln
185 190 195GGG ATA TTT AAT ATT CAA AAT TTT ATA AAC ACC CTT TTA AAA GAC TAC 679Gly Ile Phe Asn Ile Gln Asn Phe Ile Asn Thr Leu Leu Lys Asp Tyr
200 205 210CAT TTA AAA GAA ATG CCT GAA ATG GAA GAT GAA TTT TTA GAA TAT TGT 727His Leu Lys Glu Met Pro Glu Met Glu Asp Glu Phe Leu Glu Tyr Cys215 220 225 230GCC AAA AAC CCG AGC TAT GAA GAA GCG TAT CTC AAA TTT GGG GAT AAG 775Ala Lys Asn Pro Ser Tyr Glu Glu Ala Tyr Leu Lys Phe Gly Asp Lys
235 240 245CTT TTA GAA TAC GAG CTG TTG GGT AAG ATC AAG CGC ATC AAT CAC ATT 823Leu Leu Glu Tyr Glu Leu Leu Gly Lys Ile Lys Arg Ile Asn His Ile
250 255 260GTG GTG TTA GCG TGATTTTGGC ATGCGATGTG GGGTTAAAAC GCATTGGCAT CGCTG 880Val Val Leu Ala
265CGCTTTTAAA TGGCGT 896
(2) Sequence 1278 data:
(i) sequence characteristics:
(A) length: 266 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1278: met Lys Ser His Phe Gln Tyr Ser Thr Leu Glu Asn Ile Pro Lys Ala 151015 Phe Asp Ile Leu Lys Asp Pro Pro Lys Lys Leu Tyr Cys Val Gly Asp
20 25 30Thr Lys Leu Leu Asp Thr Pro Leu Lys Val Ala Ile Ile Gly Thr Arg
35 40 45Arg Pro Thr Pro Tyr Ser Lys Gln His Thr Ile Thr Leu Ala Arg Glu
50 55 60Leu Ala Lys Asn Gly Ala Val Ile Val Ser Gly Gly Ala Leu Gly Val65 70 75 80Asp Ile Ile Ala Gln Glu Asn Ala Leu Pro Lys Thr Ile Met Leu Ser
85 90 95Pro Cys Ser Leu Asp Phe Ile Tyr Pro Thr Asn Asn His Lys Val Ile
100 105 110Gln Glu Ile Ala Gln Asn Gly Leu Ile Leu Ser Glu Tyr Glu Lys Asp
115 120 125Phe Met Pro Ile Lys Gly Ser Phe Leu Ala Arg Asn Arg Leu Val Ile
130 135 140Ala Leu Ser Asp Val Val Ile Ile Pro Gln Ala Asp Leu Lys Ser Gly145 150 155160Ser Met Ser Ser Ala Arg Leu Ala Gln Lys Tyr Gln Lys Pro Leu Phe
165 170 175Val Leu Pro Gln Arg Leu Asn Glu Ser Asp Gly Thr Asn Glu Leu Leu
180 185 190Glu Lys Gly Gln Ala Gln Gly Ile Phe Asn Ile Gln Asn Phe Ile Asn
195 200 205Thr Leu Leu Lys Asp Tyr His Leu Lys Glu Met Pro Glu Met Glu Asp
210 215 220Glu Phe Leu Glu Tyr Cys Ala Lys Asn Pro Ser Tyr Glu Glu Ala Tyr225 230 235 240Leu Lys Phe Gly Asp Lys Leu Leu Glu Tyr Glu Leu Leu Gly Lys Ile
245 250 255Lys Arg Ile Asn His Ile Val Val Leu Ala
260 265
(2) Sequence 1279 data:
(i) sequence characteristics:
(A) length: 459bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 82...408
(D) Other information:
(xi) Description of the sequence: sequence 1279: TAAAACGCTC TTGAAAGGGT GAGCGTGGAA TTTGCTTCTA TCGTTTGGTT GCTCATAGTC 60AATATTCTGA TTTTTATTCT C ATG CTG GTG GAT AAA AAT TCG GCT GAT CAA 111
Met Leu Val AspLys Asn Ser Ala Asp Gln
1 5 10AAA ATG TGG CGT ATT CCT GAA AAA GCT TTG TGG GTT TTA TCG CTC CTT 159Lys Met Trp Arg Ile Pro Glu Lys Ala Leu Trp Val Leu Ser Leu Leu
15 20 25GGC GGG TCT GTC GGG TTT TTG GTC GCT ATG GTT GTG TCC CAC CAT AAG 207Gly Gly Ser Val Gly Phe Leu Val Ala Met Val Val Ser His His Lys
30 35 40ATC TTA AAG CCT GAG TTT AAA TAC GGC GTT TCG CTC ATT TAC TTG ATA 255Ile Leu Lys Pro Glu Phe Lys Tyr Gly Val Ser Leu Ile Tyr Leu Ile
45 50 55GAG AGC ACA ATC CTT TAC TTT GTC AGC AAA GAT CTT TCT TGG ATA GTA 303Glu Ser Thr Ile Leu Tyr Phe Val Ser Lys Asp Leu Ser Trp Ile Val
60 65 70GCG CTA ACG ATA TTC TCA CTA TCT TTG ATA CTG GTA GCG TTT AAG ATC 351Ala Leu Thr Ile Phe Ser Leu Ser Leu Ile Leu Val Ala Phe Lys Ile75 80 85 90TTC CTC CTT AAA GAC AAC CCT AAC AAA CGC TTC AAA AAC AAC AAG AGG 399Phe Leu Leu Lys Asp Asn Pro Asn Lys Arg Phe Lys Asn Asn Lys Arg
95 100 105GAT AAA AAA TAATGTCTTA TTTTTTTAAA ATCATTCTGG GCACAAGCGT GATCGTGGG 457Asp Lys LysGG 459
(2) Sequence 1280 data:
(i) sequence characteristics:
(A) length: 109 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1280: met Leu Val Asp Lys Asn Ser Ala Asp Gln Lys Met Trp Arg Ile Pro 151015 Glu Lys Ala Leu Trp Val Leu Ser Leu Leu Gly Gly Ser Val Gly Phe
20 25 30Leu Val Ala Met Val Val Ser His His Lys Ile Leu Lys Pro Glu Phe
35 40 45Lys Tyr Gly Val Ser Leu Ile Tyr Leu Ile Glu Ser Thr Ile Leu Tyr
50 55 60Phe Val Ser Lys Asp Leu Ser Trp Ile Val Ala Leu Thr Ile Phe Ser65 70 75 80Leu Ser Leu Ile Leu Val Ala Phe Lys Ile Phe Leu Leu Lys Asp Asn
85 90 95Pro Asn Lys Arg Phe Lys Asn Asn Lys Arg Asp Lys Lys
100 105
(2) Sequence 1281 data:
(i) sequence characteristics:
(A) length: 399bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 47...379
(D) Other information:
(xi) Description of the sequence: sequence 1281: AGCGCTCAAA TCATTTATTG GTTATCAAAA TATTTTAGGA GTGAGT ATG GAA AAT 55
Met Glu Asn
1GAT GTT AAA GAA GAT CTA GAG CAA GCA AGA CCA AAG TTA GAG CCA GAA 103Asp Val Lys Glu Asp Leu Glu Gln Ala Arg Pro Lys Leu Glu Pro Glu
5 10 15AAG CAA AAG CAA GAG CCA GAG GAA CAG AAA CAA GAA AAA CAA GAC AAA 151Lys Gln Lys Gln Glu Pro Glu Glu Gln Lys Gln Glu Lys Gln Asp Lys20 25 30 35CAA GAG CAG AAG CCA AAG CAA GAA AAA GAA GAG TCA AAG AGC AAG GAA 199Gln Glu Gln Lys Pro Lys Gln Glu Lys Glu Glu Ser Lys Ser Lys Glu
40 45 50CAA GAA GAA AAC AAA AAA CAA AAG AGA TCT AGC TAT ATT TTT TGG GGA 247Gln Glu Glu Asn Lys Lys Gln Lys Arg Ser Ser Tyr Ile Phe Trp Gly
55 60 65TGT ATT ATT GGT TTG TGT ATA GTT GTT ATT ATT GCC AAA ATT ATT GCG 295Cys Ile Ile Gly Leu Cys Ile Val Val Ile Ile Ala Lys Ile Ile Ala
70 75 80TTT GGC GGA TCT AGT GAG GAG GCA AAA GCA GAC AAA CCA AAA AAC TCT 343Phe Gly Gly Ser Ser Glu Glu Ala Lys Ala Asp Lys Pro Lys Asn Ser
85 90 95TTA AGT ATG CTG AAA AAC TTT TAC CTA CCG ATA TTA TAAAAGATAA TCTTAA 395Leu Ser Met Leu Lys Asn Phe Tyr Leu Pro Ile Leu100 105 110TAAC 399
(2) Sequence 1282 data:
(i) sequence characteristics:
(A) length: 111 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1282: met Glu Asn Asp Val Lys Glu Asp Leu Glu Gln Ala Arg Pro Lys Leu 151015 Glu Pro Glu Lys Gln Lys Gln Glu Pro Glu Glu Gln Lys Gln Glu Lys
20 25 30Gln Asp Lys Gln Glu Gln Lys Pro Lys Gln Glu Lys Glu Glu Ser Lys
35 40 45Ser Lys Glu Gln Glu Glu Asn Lys Lys Gln Lys Arg Ser Ser Tyr Ile
50 55 60Phe Trp Gly Cys Ile Ile Gly Leu Cys Ile Val Val Ile Ile Ala Lys65 70 75 80Ile Ile Ala Phe Gly Gly Ser Ser Glu Glu Ala Lys Ala Asp Lys Pro
85 90 95Lys Asn Ser Leu Ser Met Leu Lys Asn Phe Tyr Leu Pro Ile Leu
100 105 110
(2) Sequence 1283 data:
(i) sequence characteristics:
(A) length: 1627bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 21...1568
(D) Other information:
(xi) Description of the sequence: sequence 1283: TCTAAATCCT AATCTAACAA ATG AAA CAA AAG CTT AAA GCT CAA ATC AAA 50
Met Lys Gln Lys Leu Lys Ala Gln Ile Lys
1 5 10GAG CGC ATG GCT TCT ATC GCT TAT AAT GAA AAA GGG TTT CCT AGC CCC 98Glu Arg Met Ala Ser Ile Ala Tyr Asn Glu Lys Gly Phe Pro Ser Pro
15 20 25TTT TTA TTT AAA GAC TTG AAA AAA GCC GCG CTC AAA ATC ATA GAA GCC 146Phe Leu Phe Lys Asp Leu Lys Lys Ala Ala Leu Lys Ile Ile Glu Ala
30 35 40ATG CGC ACA AAC ACA GAA ATT TTA GTG GTG GGC GAT TAT GAC GCT GAC 194Met Arg Thr Asn Thr Glu Ile Leu Val Val Gly Asp Tyr Asp Ala Asp
45 50 55GGC GTG ATT AGC TCT GCT ATC ATG GCA AAA TTT TTT GAA AGC CTG AAC 242Gly Val Ile Ser Ser Ala Ile Met Ala Lys Phe Phe Glu Ser Leu Asn
60 65 70TAT AAG CAT GTC CGC ATT GCA ATC CCT AAT CGC TTC ATG GAT GGC TAT 290Tyr Lys His Val Arg Ile Ala Ile Pro Asn Arg Phe Met Asp Gly Tyr75 80 85 90GGG ATT TCT AAA AAA TTT TTA GAA AAA CAC CAC GCC CCT TTA ATC ATC 338Gly Ile Ser Lys Lys Phe Leu Glu Lys His His Ala Pro Leu Ile Ile
95 100 105ACG GTG GAT AAC GGG ATT AAC GCC TTT GAA GCC GCG CGA TTT TGT AAA 386Thr Val Asp Asn Gly Ile Asn Ala Phe Glu Ala Ala Arg Phe Cys Lys
110 115 120GAA AAA AAT TAC ACC CTT ATC ATC ACA GAT CAC CAT TGC TTA CAC CAT 434Glu Lys Asn Tyr Thr Leu Ile Ile Thr Asp His His Cys Leu His His
125 130 135GAT GAA GTC CCA GAC GCT TAT GCG GTG ATC AAC CCC AAG CAA CCG GAT 482Asp Glu Val Pro Asp Ala Tyr Ala Val Ile Asn Pro Lys Gln Pro Asp
140 145 150TGT GAT TTT ATC CAA AAGGAA GTG TGC GGG GCG TTG GTA GCG TTT TAT 530Cys Asp Phe Ile Gln Lys Glu Val Cys Gly Ala Leu Val Ala Phe Tyr155 160 165 170TTG TGC TAT GGG ATC CAT CAG CTT TTA GGA AAA GAA AAA AGC CAT TCT 578Leu Cys Tyr Gly Ile His Gln Leu Leu Gly Lys Glu Lys Ser His Ser
175 180 185AGT GAG TTA TTA TGT TTA GCG GGC GTG GCG ACT ATT GCT GAC ATG ATG 626Ser Glu Leu Leu Cys Leu Ala Gly Val Ala Thr Ile Ala Asp Met Met
190 195 200CCT TTG ACT TTT TTT AAC CGC TTT TTA GTT TCT AAA GCC TTG TAT TTT 674Pro Leu Thr Phe Phe Asn Arg Phe Leu Val Ser Lys Ala Leu Tyr Phe
205 210 215TTG CAA AAA GAA TCC TTA GGG GCG ATG GGT TTT TTG CGC CAA AGA GAA 722Leu Gln Lys Glu Ser Leu Gly Ala Met Gly Phe Leu Arg Gln Arg Glu
220 225 230GTT TTT AGA AAA CGC TCT TTA AAA GCG AGT GAT ATT TCT TTT AAT ATC 770Val Phe Arg Lys Arg Ser Leu Lys Ala Ser Asp Ile Ser Phe Asn Ile235 240 245 250GCC CCC TTA ATC AAC TCC GCA GGG CGC ATG CAA GAT GCG AAA ATG GCT 818Ala Pro Leu Ile Asn Ser Ala Gly Arg Met Gln Asp Ala Lys Met Ala
255 260 265TTA GAT TTT TTA AGC GCG AAT AAT TCT CAA GAT GGC TAT TCT TTG TAT 866Leu Asp Phe Leu Ser Ala Asn Asn Ser Gln Asp Gly Tyr Ser Leu Tyr
270 275 280GAA CGC TTG AAA GCA TGC AAT TTG AAG CGT AAA ATG ATC CAA CAG CAG 914Glu Arg Leu Lys Ala Cys Asn Leu Lys Arg Lys Met Ile Gln Gln Gln
285 290 295GTT TTT GAA GAA GCT TTT AAG CAT GCG ATG GTT GGA GAA AAA ATT ATC 962Val Phe Glu Glu Ala Phe LysHis Ala Met Val Gly Glu Lys Ile Ile
300 305 310GTC GCT TTT AAG GAC AAT TGG CAT GAG GGA GTG CTG GGG ATT GTG GCT 1010Val Ala Phe Lys Asp Asn Trp His Glu Gly Val Leu Gly Ile Val Ala315 320 325 330TCA AAA TTA GTG GAA GCC ACT CAA AAG CCA AGC CTG GTT TTT ACC TTT 1058Ser Lys Leu Val Glu Ala Thr Gln Lys Pro Ser Leu Val Phe Thr Phe
335 340 345AAA GAA GGG GTG TAT AAA GGG AGC GCT CGT AGC TCT TCA AAC ATT GAC 1106Lys Glu Gly Val Tyr Lys Gly Ser Ala Arg Ser Ser Ser Asn Ile Asp
350 355 360TTG ATT GAC GCT TTG AAT GGG GTT TCT TCT TTA TTG GTC GGC TAT GGA 1154Leu Ile Asp Ala Leu Asn Gly Val Ser Ser Leu Leu Leu Gly Tyr Gly
365 370 375GGG CAT AGG CAA GCT TGC GGG TTG AGC GTT GAA AAA AAC AAT ATC ATC 1202Gly His Arg Gln Ala Cys Gly Leu Ser Val Glu Lys Asn Asn Ile Ile
380 385 390TCG CTC TTT GAA ACT TTA GAA AAT TTT GAT TTT AAA GTT TTA CCT TTT 1250Ser Leu Phe Glu Thr Leu Glu Asn Phe Asp Phe Lys Val Leu Pro Phe395 400 405 410TGT AAA ACA GAG CCC CCT TTA ACG CTC AAA TTA AAA GAC ATT GAC AGA 1298Cys Lys Thr Glu Pro Pro Leu Thr Leu Lys Leu Lys Asp Ile Asp Arg
415 420 425GAG CTT TTA GAG ATT ATA GAA ATG GGC GAA CCT TAT GGG CAA GAA AAC 1346Glu Leu Leu Glu Ile Ile Glu Met Gly Glu Pro Tyr Gly Gln Glu Asn
430 435 440CCT GAA CCC CTA TTC CAA GCA AAA AAT TTA GAA GTC ATA GAA GAA AAA 1394Pro Glu Pro Leu Phe Gln Ala Lys Asn Leu Glu Val Ile Glu Glu Lys
445 450 455ATC ATT AAA GAA AGC CAC CAG GTT TTG CGT TTT AAG GAT AAA GAA TGC 1442Ile Ile Lys Glu Ser His Gln Val Leu Arg Phe Lys Asp Lys Glu Cys
460 465 470GTC AAA GAG GCT ATT TAT TTT AGC GCT GAG CGG TTT TTG AAA GCG GGC 1490Val Lys Glu Ala Ile Tyr Phe Ser Ala Glu Arg Phe Leu Lys Ala Gly475 480 485 490GAA AAG GTG AGC GTG CTT TTT AGC GTG GAA TTA GAT GAG TGT TCT AAT 1538Glu Lys Val Ser Val Leu Phe Ser Val Glu Leu Asp Glu Cys Ser Asn
495 500 505GAG CCT AAA ATG TTT GTT AAA AGT TTG TTG TAGTGCCTTT TGTTGAAGAA GAA 1591Glu Pro Lys Met Phe Val Lys Ser Leu Leu
510 515TTTGAAATTT TAAAACCCAC CAAAGCCTTG TTTTTT 1627
(2) Sequence 1284 data:
(i) sequence characteristics:
(A) length: 516 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1284: met Lys Gln Lys Leu Lys Ala Gln Ile Lys Glu Arg Met Ala Ser Ile 151015 Ala Tyr Asn Glu Lys Gly Phe Pro Ser Pro Phe Leu Phe Lys Asp Leu
20 25 30Lys Lys Ala Ala Leu Lys Ile Ile Glu Ala Met Arg Thr Asn Thr Glu
35 40 45Ile Leu Val Val Gly Asp Tyr Asp Ala Asp Gly Val Ile Ser Ser Ala
50 55 60Ile Met Ala Lys Phe Phe Glu Ser Leu Asn Tyr Lys His Val Arg Ile65 70 75 80Ala Ile Pro Asn Arg Phe Met Asp Gly Tyr Gly Ile Ser Lys Lys Phe
85 90 95Leu Glu Lys His His Ala Pro Leu Ile Ile Thr Val Asp Asn Gly Ile
100 105 110Asn Ala Phe Glu Ala Ala Arg Phe Cys Lys Glu Lys Asn Tyr Thr Leu
115 120 125Ile Ile Thr Asp His His Cys Leu His His Asp Glu Val Pro Asp Ala
130 135 140Tyr Ala Val Ile Asn Pro Lys Gln Pro Asp Cys Asp Phe Ile Gln Lys145 150 155 160Glu Val Cys Gly Ala Leu Val Ala Phe Tyr Leu Cys Tyr Gly Ile His
165 170 175Gln Leu Leu Gly Lys Glu Lys Ser His Ser Ser Glu Leu Leu Cys Leu
180 185 190Ala Gly Val Ala Thr Ile Ala Asp Met Met Pro Leu Thr Phe Phe Asn
195 200 205Arg Phe Leu Val Ser Lys Ala Leu Tyr Phe Leu Gln Lys Glu Ser Leu
210 215 220Gly Ala Met Gly Phe Leu Arg Gln Arg Glu Val Phe Arg Lys Arg Ser225 230 235 240Leu Lys Ala Ser Asp Ile Ser Phe Asn Ile Ala Pro Leu Ile Asn Ser
245 250 255Ala Gly Arg Met Gln Asp Ala Lys Met Ala Leu Asp Phe Leu Ser Ala
260 265 270Asn Asn Ser Gln Asp Gly Tyr Ser Leu Tyr Glu Arg Leu Lys Ala Cys
275 280 285Asn Leu LysArg Lys Met Ile Gln Gln Gln Val Phe Glu Glu Ala Phe
290 295 300Lys His Ala Met Val Gly Glu Lys Ile Ile Val Ala Phe Lys Asp Asn305 310 315 320Trp His Glu Gly Val Leu Gly Ile Val Ala Ser Lys Leu Val Glu Ala
325 330 335Thr Gln Lys Pro Ser Leu Val Phe Thr Phe Lys Glu Gly Val Tyr Lys
340 345 350Gly Ser Ala Arg Ser Ser Ser Asn Ile Asp Leu Ile Asp Ala Leu Asn
355 360 365Gly Val Ser Ser Leu Leu Leu Gly Tyr Gly Gly His Arg Gln Ala Cys
370 375 380Gly Leu Ser Val Glu Lys Asn Asn Ile Ile Ser Leu Phe Glu Thr Leu385 390 395 400Glu Asn Phe Asp Phe Lys Val Leu Pro Phe Cys Lys Thr Glu Pro Pro
405 410 415Leu Thr Leu Lys Leu Lys Asp Ile Asp Arg Glu Leu Leu Glu Ile Ile
420 425 430Glu Met Gly Glu Pro Tyr Gly Gln Glu Asn Pro Glu Pro Leu Phe Gln
435 440 445Ala Lys Asn Leu Glu Val Ile Glu Glu Lys Ile Ile Lys Glu Ser His
450 455 460Gln Val Leu Arg Phe Lys Asp Lys Glu Cys Val Lys Glu Ala Ile Tyr465 470 475 480Phe Ser Ala Glu Arg Phe Leu Lys Ala Gly Glu Lys Val Ser Val Leu
485 490 495Phe Ser Val Glu Leu Asp Glu Cys Ser Asn Glu Pro Lys Met Phe Val
500 505 510Lys Ser Leu Leu
515
(2) Sequence 1285 data:
(i) sequence characteristics:
(A) length: 961bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 51...908
(D) Other information:
(xi) Description of the sequence: sequence 1285: ATCGTAATGA AATAATCACC ACCCCTATAA GCTTTGTAGC GACGGCTAAC ATG CTT 56
Met Leu
1TTA GAA AGC GGT TAT ACA CCC GTA TTT GCT GGA ATT AAA AAC GAT GGC 104Leu Glu Ser Gly Tyr Thr Pro Val Phe Ala Gly Ile Lys Asn Asp Gly
5 10 15AAT ATA GAT GAA TTA GCC CTA GAA AAG CTC ATT AAC GAA AGA ACC AAA 152Asn Ile Asp Glu Leu Ala Leu Glu Lys Leu Ile Asn Glu Arg Thr Lys
20 25 30GCC ATA GTG AGC GTG GAT TAT GCC GGT AAA AGC GTG GAA GTA GAA AGC 200Ala Ile Val Ser Val Asp Tyr Ala Gly Lys Ser Val Glu Val Glu Ser35 40 45 50GTT CAA AAG CTT TGC AAA AAG CAT TCT TTG AGC TTT CTT TCT GAC AGC 248Val Gln Lys Leu Cys Lys Lys His Ser Leu Ser Phe Leu Ser Asp Ser
55 60 65TCG CAT GCT CTA GGA AGC GAG TAT CAA AAC AAA AAA GTA GGA GGC TTT 296Ser His Ala Leu Gly Ser Glu Tyr Gln Asn Lys Lys Val Gly Gly Phe
70 75 80GCG TTA GCG AGC GTG TTT AGT TTC CAT GCC ATT AAG CCC ATC ACT ACG 344Ala Leu Ala Ser Val Phe Ser Phe His Ala Ile Lys Pro Ile Thr Thr
85 90 95GCT GAA GGG GGA GCG GTC GTT ACT AAC GAT AGC GAA TTG CAT GAA AAA 392Ala Glu Gly Gly Ala Val Val Thr Asn Asp Ser Glu Leu His Glu Lys
100 105 110ATG AAA TTG TTT CGC TCT CAT GGC ATG CTC AAA AAA GAT TTT TTT GAA 440Met Lys Leu Phe Arg Ser His Gly Met Leu Lys Lys Asp Phe Phe Glu115 120 125 130
GGC GAA GTC AAA AGC ATA GGG CAT AAC TTC CGC TTG AAT GAA ATC CAA 488Gly Glu Val Lys Ser Ile Gly His Asn Phe Arg Leu Asn Glu Ile Gln
135 140 145AGC GCT TTG GGT TTG AGC CAG CTT AAA AAA GCC CCC TTT TTA ATG CAA 536Ser Ala Leu Gly Leu Ser Gln Leu Lys Lys Ala Pro Phe Leu Met Gln
150 155 160AAA AGA GAA GAA GCC GCT CTA ACC TAT GAC AGG ATT TTT AAA GAT AAC 584Lys Arg Glu Glu Ala Ala Leu Thr Tyr Asp Arg Ile Phe Lys Asp Asn
165 170 175CCT TAT TTC ACC CCT TTA CAC CCC TTG TTA AAA GAT AAA AGC TCT AAC 632Pro Tyr Phe Thr Pro Leu His Pro Leu Leu Lys Asp Lys Ser Ser Asn
180 185 190CAC CTT TAT CCT ATT TTA ATG CAC CAA AAA TTT TTT ACA TGC AAA AAA 680His Leu Tyr Pro Ile Leu Met His Gln Lys Phe Phe Thr Cys Lys Lys195 200 205 210CTC ATT TTA GAA AGT TTG CAC AAG CGT GGC ATT TTA GCC CAA GTG CAT 728Leu Ile Leu Glu Ser Leu His Lys Arg Gly Ile Leu Ala Gln Val His
215 220 225TAC AAG CCC ATT TAT CAA TAC CAA TTG TAC CAA CAG CTC TTC AAT ACA 776Tyr Lys Pro Ile Tyr Gln Tyr Gln Leu Tyr Gln Gln Leu Phe Asn Thr
230 235 240GCC CCA TTA AAA AGC GCA GAG GAT TTC TAT CAC GCT GAA ATT TCC TTG 824Ala Pro Leu Lys Ser Ala Glu Asp Phe Tyr His Ala Glu Ile Ser Leu
245 250 255CCT TGT CAT GCG AAT TTA AAT TTA GAG AGC GTT CAA AAC ATC GCT CAT 872Pro Cys His Ala Asn Leu Asn Leu Glu Ser Val Gln Asn Ile Ala His
260265270 AGC GTT TTA AAA ACT TTT GAG AGT TTT AAA ATA GAA TGAGTTTCAT TTAGGG 924Ser Val Leu Lys Thr Phe Glu Ser Phe Lys Ile Glu 275280285 CTTCAAATCT TAATCATTAA GAATGGTGCG GAAGAAA 961(2) sequence 1286 data: (i) sequence characteristics: (A) length: 286 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1286: met Leu Leu Glu Ser Gly Tyr Thr Pro Val Phe Ala Gly Ile Lys Asn 151015 Asp Gly Asn Ile Asp Glu Leu Ala Leu Glu Lys Leu Ile Asn Glu Arg
20 25 30Thr Lys Ala Ile Val Ser Val Asp Tyr Ala Gly Lys Ser Val Glu Val
35 40 45Glu Ser Val Gln Lys Leu Cys Lys Lys His Ser Leu Ser Phe Leu Ser
50 55 60Asp Ser Ser His Ala Leu Gly Ser Glu Tyr Gln Asn Lys Lys Val Gly65 70 75 80Gly Phe Ala Leu Ala Ser Val Phe Ser Phe His Ala Ile Lys Pro Ile
85 90 95Thr Thr Ala Glu Gly Gly Ala Val Val Thr Asn Asp Ser Glu Leu His
100 105 110Glu Lys Met Lys Leu Phe Arg Ser His Gly Met Leu Lys Lys Asp Phe
115 120 125Phe Glu Gly Glu Val Lys Ser Ile Gly His Asn Phe Arg Leu Asn Glu
130 135 140Ile Gln Ser Ala Leu Gly Leu Ser Gln Leu Lys Lys Ala Pro Phe Leu145 150 155 160Met Gln Lys Arg Glu Glu Ala Ala Leu Thr Tyr Asp Arg Ile Phe Lys
165 170 175Asp Asn Pro Tyr Phe Thr Pro Leu His Pro Leu Leu Lys Asp Lys Ser
180 185 190Ser Asn His Leu Tyr Pro Ile Leu Met His Gln Lys Phe Phe Thr Cys
195 200 205Lys Lys Leu Ile Leu Glu Ser Leu His Lys Arg Gly Ile Leu Ala Gln
210 215 220Val His Tyr Lys Pro Ile Tyr Gln Tyr Gln Leu Tyr Gln Gln Leu Phe225 230 235 240Asn Thr Ala Pro Leu Lys Ser Ala Glu Asp Phe Tyr His Ala Glu Ile
245 250 255Ser Leu Pro Cys His Ala Asn Leu Asn Leu Glu Ser Val Gln Asn Ile
260 265 270Ala His Ser Val Leu Lys Thr Phe Glu Ser Phe Lys Ile Glu
275280285 (2) sequence 1287 data: (i) sequence characteristics: (A) length: 728bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 692 (D) other information: (xi) Description of the sequence: sequence 1287: TAATGGGCCT TTGA ATG CGT TTT GTC TAT CAC CCT TTA GCC AAA GAG CCT 50
Met Arg Phe Val Tyr His Pro Leu Ala Lys Glu Pro
1 5 10GTT TTA AAA ATA GAA GGC GAG AGT TAT ACG CAT TTA TAC CGA TCA AGG 98Val Leu Lys Ile Glu Gly Glu Ser Tyr Thr His Leu Tyr Arg Ser Arg
15 20 25CGT GTC AAA AGT GCG AGT CGT TTG GAT TTG AGA AAT TTA AAA GAC GGC 146Arg Val Lys Ser Ala Ser Arg Leu Asp Leu Arg Asn Leu Lys Asp Gly
30 35 40TTT TTA TAC ACC TAT GAG CAT GCA GAA ATC ACT AAA AAA CAC GCC CTT 194Phe Leu Tyr Thr Tyr Glu His Ala Glu Ile Thr Lys Lys His Ala Leu45 50 55 60TTA AAG CTA GTG GGC GCG CGA TTA TTA GAG GTT ATG GCC AGT AAA AAA 242Leu Lys Leu Val Gly Ala Arg Leu Leu Glu Val Met Ala Ser Lys Lys
65 70 75ACG CAT TTG ATT TTA AGC GTG ATT GAA ATC AAA AAC ATT GAA AAA ATC 290Thr His Leu Ile Leu Ser Val Ile Glu Ile Lys Asn Ile Glu Lys Ile
80 85 90CTA CCC TTT TTA AAT CAG TTA GGC GTG AGC AAG TTG AGT TTA TTC TAT 338Leu Pro Phe Leu Asn Gln Leu Gly Val Ser Lys Leu Ser Leu Phe Tyr
95 100 105GCG GAT TTT AGC CAA CGC AAT GAA AAA ATA GAC ATC GCT AAA TTA GAG 386Ala Asp Phe Ser Gln Arg Asn Glu Lys Ile Asp Ile Ala Lys Leu Glu
110 115 120CGC TTT CAA AAG ATT TTG ATC CAT TCT TGC GAG CAG TGT GGT AGG AGT 434Arg Phe Gln Lys Ile Leu Ile His Ser Cys Glu Gln Cys Gly Arg Ser125 130 135 140GCT TTA ATG GAA TTG GAA GTG TTT TCA AAC ACT AAA GAG GCG CTA AAA 482Ala Leu Met Glu Leu Glu Val Phe Ser Asn Thr Lys Glu Ala Leu Lys
145 150 155GCC TAT CCT AAG GCG AGC GTT TTG GAT TTT AAG GGC GAA ACC TTA NCC 530Ala Tyr Pro Lys Ala Ser Val Leu Asp Phe Lys Gly Glu Thr Leu Xaa
160 165 170GCA AGC GCG GAT TTT GAA AAG GGC GTT ATC ATA GGG CCT GAG GGG GGC 578Ala Ser Ala Asp Phe Glu Lys Gly Val Ile Ile Gly Pro Glu Gly Gly
175 180 185TTT AGC GAA CCA GAA AGA GGG TAT TTT AAA GAG CGT GAA ATT TAT CGC 626Phe Ser Glu Pro Glu Arg Gly Tyr Phe Lys Glu Arg Glu Ile Tyr Arg
190 195 200ATC CCG TTA GAT ATG GTG CTA AAG TCT GAG AGT GCA TGC GTG TTT GTA 674Ile Pro Leu Asp Met Val Leu Lys Ser Glu Ser Ala Cys Val Phe Val205 210 215 220GCG AGT ATC GCA CAA GTT TAGGGGGTTA TTGGGGATTT TAAATCCTAA AAAATC 728Ala Ser Ile Ala Gln Val
225 (2) sequence 1288 data: (i) sequence characteristics: length (A): 226 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1288: met Arg Phe Val Tyr His Pro Leu Ala Lys Glu Pro Val Leu Lys Ile 151015 Glu Gly Glu Ser Tyr Thr His Leu Tyr Arg Ser Arg Arg Val Lys Ser
20 25 30Ala Ser Arg Leu Asp Leu Arg Asn Leu Lys Asp Gly Phe Leu Tyr Thr
35 40 45Tyr Glu His Ala Glu Ile Thr Lys Lys His Ala Leu Leu Lys Leu Val
50 55 60Gly Ala Arg Leu Leu Glu Val Met Ala Ser Lys Lys Thr His Leu Ile65 70 75 80Leu Ser Val Ile Glu Ile Lys Asn Ile Glu Lys Ile Leu Pro Phe Leu
8590 95Asn Gln Leu Gly Val Ser Lys Leu Ser Leu Phe Tyr Ala Asp Phe Ser
100 105 110Gln Arg Asn Glu Lys Ile Asp Ile Ala Lys Leu Glu Arg Phe Gln Lys
115 120 125Ile Leu Ile His Ser Cys Glu Gln Cys Gly Arg Ser Ala Leu Met Glu
130 135 140Leu Glu Val Phe Ser Asn Thr Lys Glu Ala Leu Lys Ala Tyr Pro Lys145 150 155 160Ala Ser Val Leu Asp Phe Lys Gly Glu Thr Leu Xaa Ala Ser Ala Asp
165 170 175Phe Glu Lys Gly Val Ile Ile Gly Pro Glu Gly Gly Phe Ser Glu Pro
180 185 190Glu Arg Gly Tyr Phe Lys Glu Arg Glu Ile Tyr Arg Ile Pro Leu Asp
195 200 205Met Val Leu Lys Ser Glu Ser Ala Cys Val Phe Val Ala Ser Ile Ala
210215220 Gln Val225 (2) sequence 1289 data: (i) sequence characteristics: length (A): 888bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 840 (D) other information: (xi) Description of the sequence: sequence 1289: TTATGAAATT GA ATG ACC CTT TCG CAA GCC CTA AAC AAA GCC AAA AAA GGA 51
Met Thr Leu Ser Gln Ala Leu Asn Lys Ala Lys Lys Gly
1 5 10TTA TCG CAA AAA GGT TTT AGG GGG GGC TTA GAA TCT GAA ATT TTA TTA 99Leu Ser Gln Lys Gly Phe Arg Gly Gly Leu Glu Ser Glu Ile Leu Leu
15 20 25GGC TTT GTC TTG CAA AAA GAA AGG GTT TTT TTG CACACG CAT GCC TAT 147Gly Phe Val Leu Gln Lys Glu Arg Val Phe Leu His Thr His Ala Tyr30 35 40 45TTA GAG TTA AAC CAC GAA GAA GAG GTG CGT TTT TTT GAA TTG GTA GAA 195Leu Glu Leu Asn His Glu Glu Glu Val Arg Phe Phe Glu Leu Val Glu
50 55 60AAG CGC TTG AAT AAC TGC CCC ATA GAG TAT TTA TTA GAA AGC TGT GAT 243Lys Arg Leu Asn Asn Cys Pro Ile Glu Tyr Leu Leu Glu Ser Cys Asp
65 70 75TTT TAT GGG CGC TCT TTT TTT GTG AAT GAG CAT GTT TTA ATC CCA CGA 291Phe Tyr Gly Arg Ser Phe Phe Val Asn Glu His Val Leu Ile Pro Arg
80 85 90CCT GAA ACC GAG ATT TTG GTC CAA AAA GCC CTT GAT ATT ATT TCT CAA 339Pro Glu Thr Glu Ile Leu Val Gln Lys Ala Leu Asp Ile Ile Ser Gln
95 100 105TAC CAT TTA AAA GAG ATA GGC GAA ATC GGC ATA GGG AGC GGA TGC GTG 387Tyr His Leu Lys Glu Ile Gly Glu Ile Gly Ile Gly Ser Gly Cys Val110 115 120 125TCT GTG AGT TTG GCT TTA GAA AAC CCT AAT CTC TCT ATT TAT GCG AGC 435Ser Val Ser Leu Ala Leu Glu Asn Pro Asn Leu Ser Ile Tyr Ala Ser
130 135 140GAT ATT TCA CCA AAC GCT TTA GAA GTG GCG TCC AAA AAT ATT GAG CAC 483Asp Tle Ser Pro Asn Ala Leu Glu Val Ala Ser Lys Asn Ile Glu His
145 150 155TTT TGT CTA AAA GAG CGT GTT TTT TTA AAA CAA ACA CGC CTT TGG GAT 531Phe Cys Leu Lys Glu Arg Val Phe Leu Lys Gln Thr Arg Leu Trp Asp
160 165 170CAT ATG CCC ATG ATA GAA ATG CTT GTC TCT AAC CCG CCC TAT ATC GCT 579His Met Pro Met Ile Glu Met Leu Val Ser Asn Pro Pro TyrIle Ala
175 180 185AGA AAT TAT CCT TTG GAA AAA TCC GTC CTC AAA GAA CCG CAT GAA GCC 627Arg Asn Tyr Pro Leu Glu Lys Ser Val Leu Lys Glu Pro His Glu Ala190 195 200 205CTT TTT GGG GGG GTT AAA GGC GAT GAG ATC TTA AAA GAA ATC GTT TTT 675Leu Phe Gly Gly Val Lys Gly Asp Glu Ile Leu Lys Glu Ile Val Phe
210 215 220TTA GCC GCT AAA TTA AAA ATC CCT TTT TTG GTT TGT GAA ATG GGG TAT 723Leu Ala Ala Lys Leu Lys Ile Pro Phe Leu Val Cys Glu Met Gly Tyr
225 230 235GAC CAG TTG AAA AGC TTG AAA GAA TGC TTG GAA TTT TGC GGT TAT GAT 771Asp Gln Leu Lys Ser Leu Lys Glu Cys Leu Glu Phe Cys Gly Tyr Asp
240 245 250GCA GAG TTT TAC AAG GAT TTG AGC GGC TTT GAT AGA GGG TTT GTG GGC 819Ala Glu Phe Tyr Lys Asp Leu Ser Gly Phe Asp Arg Gly Phe Val Gly
255260265 GTT TTA AAA AGT TTT TTA AGA TAAATTAAAA CTTAATTACC CTTTTAGTGT TACA 874Val Leu Lys Ser Phe Leu Arg 270275 ATAAACAC TTAA 888 (2) sequence 1290 data: (i) sequence characteristics: length (A): 276 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1290: met Thr Leu Ser Gln Ala Leu Asn Lys Ala Lys Lys Gly Leu Ser Gln 151015 Lys Gly Phe Arg Gly Gly Leu Glu Ser Glu Ile Leu Leu Gly Phe Val
20 25 30Leu Gln Lys Glu Arg Val Phe Leu His Thr His Ala Tyr Leu Glu Leu
35 40 45Asn His Glu Glu Glu Val Arg Phe Phe Glu Leu Val Glu Lys Arg Leu
50 55 60Asn Asn Cys Pro Ile Glu Tyr Leu Leu Glu Ser Cys Asp Phe Tyr Gly65 70 75 80Arg Ser Phe Phe Val Asn Glu His Val Leu Ile Pro Arg Pro Glu Thr
85 90 95Glu Ile Leu Val Gln Lys Ala Leu Asp Ile Ile Ser Gln Tyr His Leu
100 105 110Lys Glu Ile Gly Glu Ile Gly Ile Gly Ser Gly Cys Val Ser Val Ser
115 120 125Leu Ala Leu Glu Asn Pro Asn Leu Ser Ile Tyr Ala Ser Asp Ile Ser
130 135 140Pro Asn Ala Leu Glu Val Ala Ser Lys Asn Ile Glu His Phe Cys Leu145 150 155 160Lys Glu Arg Val Phe Leu Lys Gln Thr Arg Leu Trp Asp His Met Pro
165 170 175Met Ile Glu Met Leu Val Ser Asn Pro Pro Tyr Ile Ala Arg Asn Tyr
180 185 190Pro Leu Glu Lys Ser Val Leu Lys Glu Pro His Glu Ala Leu Phe Gly
195 200 205Gly Val Lys Gly Asp Glu Ile Leu Lys Glu Ile Val Phe Leu Ala Ala
210 215 220Lys Leu Lys Ile Pro Phe Leu Val Cys Glu Met Gly Tyr Asp Gln Leu225 230 235 240Lys Ser Leu Lys Glu Cys Leu Glu Phe Cys Gly Tyr Asp Ala Glu Phe
245 250 255Tyr Lys Asp Leu Ser Gly Phe Asp Arg Gly Phe Val Gly Val Leu Lys
260 265 270Ser Phe Leu Arg
275 (2) sequence 1291 data: (i) sequence characteristics: length (A): 1026bp (B) type: nucleic acid (C) strandtype: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 960 (D) other information: (xi) Description of the sequence: sequence 1291: CCATCTCAAA ATAAGGACGC CTAAATC ATG GCA GAA AAA ACA GCT AAC GAT TTA 54
Met Ala Glu Lys Thr Ala Asn Asp Leu
1 5AAA CTA AGT GAG ATA GAA CTC GTG GAT TTT CGT ATT TAT GGC ATG CAA 102Lys Leu Ser Glu Ile Glu Leu Val Asp Phe Arg Ile Tyr Gly Met Gln10 15 20 25GAG GGC GTC CCT TAT GAG GGG ATT TAT GGT ATC AAT GTG GCT AAA GTC 150Glu Gly Val Pro Tyr Glu Gly Ile Tyr Gly Ile Asn Val Ala Lys Val
30 35 40CAA GAA ATC ATC CCC ATG CCC ACC CTT TTT GAA TAC CCC ACG AAT TTG 198Gln Glu Ile Ile Pro Met Pro Thr Leu Phe Glu Tyr Pro Thr Asn Leu
45 50 55GAT TAC ATT ATC GGC GTG TTT GAT TTG CGC TCC ATA ATC ATT CCG CTT 246Asp Tyr Ile Ile Gly Val Phe Asp Leu Arg Ser Ile Ile Ile Pro Leu
60 65 70ATA GAC TTG GCT AAA TGG ATA GGG ATT ATC CCA GAT AAA AGC AAG GAA 294Ile Asp Leu Ala Lys Trp Ile Gly Ile Ile Pro Asp Lys Ser Lys Glu
75 80 85AAC GAA AAA ATC GTC ATT ATC ACT GAA TTT AAC AAC GTT AAA ATG GGT 342Asn Glu Lys Ile Val Ile Ile Thr Glu Phe Asn Asn Val Lys Met Gly90 95 100 105TTT TTA GTC CAT TCG GCT AGG CGT ATC AGG CGC ATT AGC TGG AAA GAT 390Phe Leu Val His Ser Ala Arg Arg Ile Arg Arg Ile Ser Trp Lys Asp
110 115 120GTG GAG CCT GCA TCC TTT AGC GCC TCT AAT AGC ATC AAT AAAGAA AAT 438Val Glu Pro Ala Ser Phe Ser Ala Ser Asn Ser Ile Asn Lys Glu Asn
125 130 135ATT ACC GGC ACG ACA CGC ATT GAA AAC GAC AAA ACC CTG CTC ATT TTG 486Ile Thr Gly Thr Thr Arg Ile Glu Asn Asp Lys Thr Leu Leu Ile Leu
140 145 150GAT TTA GAA AGC ATT TTA GAC GAT TTA AAG CTT AAT GAA GAC GCT AAA 534Asp Leu Glu Ser Ile Leu Asp Asp Leu Lys Leu Asn Glu Asp Ala Lys
155 160 165AAC GCT AAA GAT ACC CAT AAA GAG CGT TTT GAA GGC GAA GTG TTG TTT 582Asn Ala Lys Asp Thr His Lys Glu Arg Phe Glu Gly Glu Val Leu Phe170 175 180 185TTA GAC GAT AGC AAG ACC GCA AGA AAA ACC TTA AAA AAC CAT TTG AGC 630Leu Asp Asp Ser Lys Thr Ala Arg Lys Thr Leu Lys Asn His Leu Ser
190 195 200AAA TTA GGT TTT AGC ATC ACT GAA GCT GTG GAT GGG GAA GAC GGG TTG 678Lys Leu Gly Phe Ser Ile Thr Glu Ala Val Asp Gly Glu Asp Gly Leu
205 210 215AAC AAA TTA GAA ATG TTA TTC AAA AAA TAC GGG GAC GAT TTG AGA AAG 726Asn Lys Leu Glu Met Leu Phe Lys Lys Tyr Gly Asp Asp Leu Arg Lys
220 225 230CAT TTG AAA TTC ATT ATT TCA GAT GTT GAA ATG CCT AAA ATG GAT GGC 774His Leu Lys Phe Ile Ile Ser Asp Val Glu Met Pro Lys Met Asp Gly
235 240 245TAT CAT TTC TTA TTC AAG CTC CAA AAA GAC CCT AGG TTT GCT TAT ATT 822Tyr His Phe Leu Phe Lys Leu Gln Lys Asp Pro Arg Phe Ala Tyr Ile250 255 260 265CCT GTG ATT TTT AAT TCT TCT ATT TGC GAT AAT TAC AGC GCT GAA AGG 870Pro Val Ile Phe Asn Ser Ser Ile Cys Asp Asn Tyr Ser Ala Glu Arg
270 275 280GCT AAA GAA ATG GGG GCT GTA GCG TAT TTA GTC AAG TTT GAC GCA GAA 918Ala Lys Glu Met Gly Ala Val Ala Tyr Leu Val Lys Phe Asp Ala Glu
285 290 295AAA TTC ACC GAA GAA ATT TCT AAG ATT TTA GAC AAG AAT GCG TAATTCTTT 969Lys Phe Thr Glu Glu Ile Ser Lys Ile Leu Asp Lys Asn Ala
300305310 TTATAAAATT GTAAAATACT CTTATCTCAA ACGCTAAAAA GGGGTTTTAA ATGGATG 1026 (1026) (2) sequence 1292 data: (i) sequence characteristics: length (A): 311 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1292: met Ala Glu Lys Thr Ala Asn Asp Leu Lys Leu Ser Glu Ile Glu Leu 151015 Val Asp Phe Arg Ile Tyr Gly Met Gln Glu Gly Val Pro Tyr Glu Gly
20 25 30Ile Tyr Gly Ile Asn Val Ala Lys Val Gln Glu Ile Ile Pro Met Pro
35 40 45Thr Leu Phe Glu Tyr Pro Thr Asn Leu Asp Tyr Ile Ile Gly Val Phe
50 55 60Asp Leu Arg Ser Ile Ile Ile Pro Leu Ile Asp Leu Ala Lys Trp Ile65 70 75 80Gly Ile Ile Pro Asp Lys Ser Lys Glu Asn Glu Lys Ile Val Ile Ile
85 90 95Thr Glu Phe Asn Asn Val Lys Met Gly Phe Leu Val His Ser Ala Arg
100 105 110Arg Ile Arg Arg Ile Ser Trp Lys Asp Val Glu Pro Ala Ser Phe Ser
115 120 125Ala Ser Asn Ser Ile Asn Lys Glu Asn Ile Thr Gly Thr Thr Arg Ile
130 135 140Glu Asn Asp Lys Thr Leu Leu Ile Leu Asp Leu Glu Ser Ile Leu Asp145 150 155 160Asp Leu Lys Leu Asn Glu Asp Ala Lys Asn Ala Lys Asp Thr His Lys
165 170 175Glu Arg Phe Glu Gly Glu Val Leu Phe Leu Asp Asp Ser Lys Thr Ala
180 185 190Arg Lys Thr Leu Lys Asn His Leu Ser Lys Leu Gly Phe Ser Ile Thr
195 200 205Glu Ala Val Asp Gly Glu Asp Gly Leu Asn Lys Leu Glu Met Leu Phe
210 215 220Lys Lys Tyr Gly Asp Asp Leu Arg Lys His Leu Lys Phe Ile Ile Ser225 230 235 240Asp Val Glu Met Pro Lys Met Asp Gly Tyr His Phe Leu Phe Lys Leu
245 250 255Gln Lys Asp Pro Arg Phe Ala Tyr Ile Pro Val Ile Phe Asn Ser Ser
260 265 270Ile Cys Asp Asn Tyr Ser Ala Glu Arg Ala Lys Glu Met Gly Ala Val
275 280 285Ala Tyr Leu Val Lys Phe Asp Ala Glu Lys Phe Thr Glu Glu Ile Ser
290295300 Lys Ile Leu Asp Lys Asn Ala 305310 (2) sequence 1293 data: (i) sequence characteristics: length (A): 753bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 697 (D) other information: (xi) Description of the sequence: sequence 1293: GATCTATAAA GAATAGCCAT AAAGAAGAAT T ATG TTA GAT TAT CGC CAA AAA 52
Met Leu Asp Tyr Arg Gln Lys
1 5ATT GAT GCTCTC ATC ACC AAA ATA GAA AAG GCT CGC ACC GCC TAT TCA 100Ile Asp Ala Leu Ile Thr Lys Ile Glu Lys Ala Arg Thr Ala Tyr Ser
10 15 20AGG CAC CAC ATT GTC AAA ATC GTG GCT GTT TCA AAA AAC GCT TCC CCA 148Arg His His Ile Val Lys Ile Val Ala Val Ser Lys Asn Ala Ser Pro
25 30 35GAA GCT ATC CAA CAT TAT TAT AAC TGC TCT CAA AGG GCT TTT GGA GAA 196Glu Ala Ile Gln His Tyr Tyr Asn Cys Ser Gln Arg Ala Phe Gly Glu40 45 50 55AAT AAA GTT CAA GAT TTA AAA ACT AAA ATG CAT TCT TTA GAG CAT TTG 244Asn Lys Val Gln Asp Leu Lys Thr Lys Met His Ser Leu Glu His Leu
60 65 70CCC CTT GAA TGG CAC ATG ATA GGC TCT TTA CAA GAA AAT AAA ATC AAT 292Pro Leu Glu Trp His Met Ile Gly Ser Leu Gln Glu Asn Lys Ile Asn
75 80 85GCG CTT TTG AGT TTA AAG CCC GCT CTT TTG CAT TCT TTA GAC TCT TTA 340Ala Leu Leu Ser Leu Lys Pro Ala Leu Leu His Ser Leu Asp Ser Leu
90 95 100 AAA CTC GCT TTG AAA ATA GAA AAG CGT TGC GAA ATA TTG GGC GTC AAT 388Lys Leu Ala Leu Lys Ile Glu Lys Arg Cys Glu Ile Leu Gly Val Asn
105 110 115TTA AAC GCT CTT TTA CAG GTT AAT AGC GCG TAT GAG GAA AGT AAA AGC 436Leu Asn Ala Leu Leu Gln Val Asn Ser Ala Tyr Glu Glu Ser Lys Ser120 125 130 135GGG GTG GTG CCT GAA GAA GCG CTA GAA ATT TAT TCT CAA ATC AGT GAA 484Gly Val Val Pro Glu Glu Ala Leu Glu Ile Tyr Ser Gln Ile Ser Glu
140 145 150ACT TGC AAG CAC CTC AAG CTT AAG GGG CTT ATG TGT ATA GGG GCA CAC 532Thr Cys Lys His Leu Lys Leu Lys Gly Leu Met Cys Ile Gly Ala His
155 160 165ACA GAT GAT GAA AAG GAA ATT GAA AAA TCC TTT ATC ACC ACC AAA AAG 580Thr Asp Asp Glu Lys Glu Ile Glu Lys Ser Phe Ile Thr Thr Lys Lys
170 175 180CTT TTT GAC CAA ATA AAG AAT GCG AGC GTT CTT TCA ATG GGC ATG AGT 628Leu Phe Asp Gln Ile Lys Asn Ala Ser Val Leu Ser Met Gly Met Ser
185 190 195GAT GAT TTT GAA TTA GCG ATT GCT TGC GGG GCG AAT CTT TTA AGG ATT 676Asp Asp Phe Glu Leu Ala Ile Ala Cys Gly Ala Asn Leu Leu Arg Ile200 205 210 215GGC TCT TTT TTG TTC AAA GAG TAAGATGCTA GAAACTTATG CACTTAAAAA TGGG 731Gly Ser Phe Leu Phe Lys Glu
220GCTGTTTTTA TCTCTGATGC GC 753 (2) sequence 1294 materials: (i) sequence characteristics: length (A): 222 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1294: met Leu Asp Tyr Arg Gln Lys Ile Asp Ala Leu Ile Thr Lys Ile Glu 151015 Lys Ala Arg Thr Ala Tyr Ser Arg His His Ile Val Lys Ile Val Ala
20 25 30Val Ser Lys Asn Ala Ser Pro Glu Ala Ile Gln His Tyr Tyr Asn Cys
35 40 45Ser Gln Arg Ala Phe Gly Glu Asn Lys Val Gln Asp Leu Lys Thr Lys
50 55 60Met His Ser Leu Glu His Leu Pro Leu Glu Trp His Met Ile Gly Ser65 70 75 80Leu Gln Glu Asn Lys Ile Asn Ala Leu Leu Ser Leu Lys Pro Ala Leu
85 90 95Leu His Ser Leu Asp Ser Leu Lys Leu Ala Leu Lys Ile Glu Lys Arg
100 105 110Cys Glu Ile Leu Gly Val Asn Leu Asn Ala Leu Leu Gln Val Asn Ser
115 120 125Ala Tyr Glu Glu Ser Lys Ser Gly Val Val Pro Glu Glu Ala Leu Glu
130 135 140Ile Tyr Ser Gln Ile Ser Glu Thr Cys Lys His Leu Lys Leu Lys Gly145 150 155 160Leu Met Cys Ile Gly Ala His Thr Asp Asp Glu Lys Glu Ile Glu Lys
165 170 175Ser Phe Ile Thr Thr Lys Lys Leu Phe Asp Gln Ile Lys Asn Ala Ser
180 185 190Val Leu Ser Met Gly Met Ser Asp Asp Phe Glu Leu Ala Ile Ala Cys
195 200 205Gly Ala Asn Leu Leu Arg Ile Gly Ser Phe Leu Phe Lys Glu
210215220 (2) sequence 1295 data: (i) sequence characteristics: length (A): 1633bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1593 (D) other information: (xi) Description of the sequence: sequence 1295: TTTTAAATTC AAAGGATAAA A ATG TAT CAA GTA GCC ATT TGC GAC CCC ATC 51
Met Tyr Gln Val Ala Ile Cys Asp Pro Ile
1 5 10CAT GCT AAA GGC ATT CAA ATT TTA GAA GCT CAA AAA GAC ATT GTC TTG 99His Ala Lys Gly Ile Gln Ile Leu Glu Ala Gln Lys Asp Ile Val Leu
15 20 25CAT GAT TAT TCC AAA TGC CCT AAA AAG GAG CTT TTA GAA AAA CTC ACT 147His Asp Tyr Ser Lys Cys Pro Lys Lys Glu Leu Leu Glu Lys Leu Thr
3035 40CCC ATG GAT GCG CTC ATC ACT CGC AGC ATG ACC CCT ATC ACA AGC GAT 195Pro Met Asp Ala Leu Ile Thr Arg Ser Met Thr Pro Ile Thr Ser Asp
45 50 55TTT TTA AAG CCC TTA ACC CAC TTA AAA TCC ATC GTG AGA GCG GGC GTG 243Phe Leu Lys Pro Leu Thr His Leu Lys Ser Ile Val Arg Ala Gly Val
60 65 70GGA GTG GAT AAT ATT GAT TTA GAA AGC TGC TCT CAA AAA GGG ATT GTA 291Gly Val Asp Asn Ile Asp Leu Glu Ser Cys Ser Gln Lys Gly Ile Val75 80 85 90GTG ATG AAT ATC CCT ACC GCT AAC ACG ATT GCC GCT GTG GAA TTG ACC 339Val Met Asn Ile Pro Thr Ala Asn Thr Ile Ala Ala Val Glu Leu Thr
95 100 105ATG GCG CAT TTG ATC AAT GCA GTG CGT TCG TTC CCT TGT GCA AAC GAT 387Met Ala His Leu Ile Asn Ala Val Arg Ser Phe Pro Cys Ala Asn Asp
110 115 120CAA ATC AAA CAC CAA AGG TTA TGG AAA AGA GAA GAT TGG TAT GGC ACG 435Gln Ile Lys His Gln Arg Leu Trp Lys Arg Glu Asp Trp Tyr Gly Thr
125 130 135GAA TTG AAA AAT AAA AAG CTG GGC ATC ATT GGT TTT GGG AAT ATT GGC 483Glu Leu Lys Asn Lys Lys Leu Gly Ile Ile Gly Phe Gly Asn Ile Gly
140 145 150TCT AGG GTG GGC ATT AGA GCA AAA GCC TTT GAA ATG GAA GTT CTA GCC 531Ser Arg Val Gly Ile Arg Ala Lys Ala Phe Glu Met Glu Val Leu Ala155 160 165 170TAT GAT CCT TAT ATC CCT TCT TCA AAA GCC ACT GAT TTA GGA GTC ATT 579Tyr Asp Pro Tyr Ile Pro Ser Ser Lys Ala Thr Asp Leu Gly Val Ile
175 180 185TAC ACG AAA AAT TTT GAA GAC ATT TTG CAA TGC GAT ATG ATC ACT ATC 627Tyr Thr Lys Asn Phe Glu Asp Ile Leu Gln Cys Asp Met Ile Thr Ile
190 195 200CAC ACC CCT AAA AAT AAA GAA ACG ATT AAC ATG ATA GGT GCT AAA GAG 675His Thr Pro Lys Asn Lys Glu Thr Ile Asn Met Ile Gly Ala Lys Glu
205 210 215ATT GAG CGC ATG AAA AAA GGG GTT ATT TTG CTC AAT TGC GCT AGG GGT 723Ile Glu Arg Met Lys Lys Gly Val Ile Leu Leu Asn Cys Ala Arg Gly
220 225 230GGG CTT TAT AAT GAA GAC GCT CTT TAT GAG GCT TTA GAA ACC AAA AAA 771Gly Leu Tyr Asn Glu Asp Ala Leu Tyr Glu Ala Leu Glu Thr Lys Lys235 240 245 250GTG CGT TGG CTT GGC ATT GAT GTC TTT TCT AAA GAG CCT GGC ATT CAC 819Val Arg Trp Leu Gly Ile Asp Val Phe Ser Lys Glu Pro Gly Ile His
255 260 265AAC AAG CTT TTA GAC TTG CCC AAT GTT TAT GCG ACC CCC CAT ATT GGC 867Asn Lys Leu Leu Asp Leu Pro Asn Val Tyr Ala Thr Pro His Ile Gly
270 275 280GCA AAC ACT TTA GAA TCC CAA GAA GAA ATT TCC AAA CAA GCC GCT CAA 915Ala Asn Thr Leu Glu Ser Gln Glu Glu Ile Ser Lys Gln Ala Ala Gln
285 290 295GGG GTT ATG GAA TCT TTA AGG GGT TCA AGC CAC CCG CAT GCT TTG AAT 963Gly Val Met Glu Ser Leu Arg Gly Ser Ser His Pro His Ala Leu Asn
300 305 310TTA CCC ATG CAA GCT TTT GAC GCG AGC GCA AAA GCC TAC TTG AAT TTA 1011Leu Pro Met Gln Ala Phe Asp Ala Ser Ala Lys Ala Tyr Leu Asn Leu315 320 325 330GCG CAA AAA TTG GGT TAT TTT TCC AGT CAA ATC CAT AAG GGC GTG TGC 1059Ala Gln Lys Leu Gly Tyr Phe Ser Ser Gln Ile His Lys Gly Val Cys
335 340 345CAA AAA ATT GAG CTC AGT CTT TGT GGG GAG ATC AAC CAA TTT AAA GAC 1107Gln Lys Ile Glu Leu Ser Leu Cys Gly Glu Ile Asn Gln Phe Lys Asp
350 355 360GCT CTT GTA GCC TTT ATG TTA GTG GGG GTG TTA AAA CCT GTT GTA GGG 1155Ala Leu Val Ala Phe Met Leu Val Gly Val Leu Lys Pro Val Val Gly
365 370 375GAT AAA ATC AAT TAC ATT AAC GCC CCC TTT GTG GCC AAA GAA AGA GGT 1203Asp Lys Ile Asn Tyr Ile Asn Ala Pro Phe Val Ala Lys Glu Arg Gly
380 385 390ATT GAG ATT AAG GTT AGC CTT AAA GAA AGC GCT TCG CCC TAT AAG AAC 1251Ile Glu Ile Lys Val Ser Leu Lys Glu Ser Ala Ser Pro Tyr Lys Asn395 400 405 410ATG CTC TCT TTA ACC CTC AAT GCG GCT AAT GGC ACA ATC AGC GTG AGC 1299Met Leu Ser Leu Thr Leu Asn Ala Ala Asn Gly Thr Ile Ser Val Ser
415 420 425GGC ACG GTG TTT GAA GAA GAT ATT TTA AAA CTC ACT GAG ATT GAT GGG 1347Gly Thr Val Phe Glu Glu Asp Ile Leu Lys Leu Thr Glu Ile Asp Gly
430 435 440TTT CAT ATT GAT ATA GAG CCA AAG GGT AAA ATG CTT TTA TTC AGG AAT 1395Phe His Ile Asp Ile Glu Pro Lys Gly Lys Met Leu Leu Phe Arg Asn
445 450 455ACG GAT ATT CCA GGC GTT ATT GGG AGT GTG GGG AAT GCG TTC GCT AGG 1443Thr Asp Ile Pro Gly Val Ile Gly Ser Val Gly Asn Ala Phe Ala Arg
460 465 470CAT GGC ATT AAC ATC GCT GAT TTT CGT TTG GGG CGT AAC ACG CAA AAA 1491His Gly Ile Asn Ile Ala Asp Phe Arg Leu Gly Arg Asn Thr Gln Lys475 480 485490GAA GCC CTA GCA CTC ATT ATT GTA GAT GAA GAA GTT TCT TTG GAA GTT 1539Glu Ala Leu Ala Leu Ile Ile Val Asp Glu Glu Val Ser Leu Glu Val
495 500 505TTA GAA GAG CTT AAA AAC ATT CCT GCG TGC TTA AGC GTT CAT TAT GTG 1587Leu Glu Glu Leu Lys Asn Ile Pro Ala Cys Leu Ser Val His Tyr Val
510515520 GTT ATT TAAGGTAGTT GGATGCGAGA TTTTTTAAAA CTTTTAAAAA 1633Val Ile (2) sequence 1296 data: (i) sequence characteristics: length (A): 524 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1296: met Tyr Gln Val Ala Ile Cys Asp Pro Ile His Ala Lys Gly Ile Gln 151015 Ile Leu Glu Ala Gln Lys Asp Ile Val Leu His Asp Tyr Ser Lys Cys
20 25 30Pro Lys Lys Glu Leu Leu Glu Lys Leu Thr Pro Met Asp Ala Leu Ile
35 40 45Thr Arg Ser Met Thr Pro Ile Thr Ser Asp Phe Leu Lys Pro Leu Thr
50 55 60His Leu Lys Ser Ile Val Arg Ala Gly Val Gly Val Asp Asn Ile Asp65 70 75 80Leu Glu Ser Cys Ser Gln Lys Gly Ile Val Val Met Asn Ile Pro Thr
85 90 95Ala Asn Thr Ile Ala Ala Val Glu Leu Thr Met Ala His Leu Ile Asn
100 105 110Ala Val Arg Ser Phe Pro Cys Ala Asn Asp Gln Ile Lys His Gln Arg
115 120 125Leu Trp Lys Arg Glu Asp Trp Tyr Gly Thr Glu Leu Lys Asn Lys Lys
130 135 140Leu Gly Ile Ile Gly Phe Gly Asn Ile Gly Ser Arg Val Gly Ile Arg145150 155 160Ala Lys Ala Phe Glu Met Glu Val Leu Ala Tyr Asp Pro Tyr Ile Pro
165 170 175Ser Ser Lys Ala Thr Asp Leu Gly Val Ile Tyr Thr Lys Asn Phe Glu
180 185 190Asp Ile Leu Gln Cys Asp Met Ile Thr Ile His Thr Pro Lys Asn Lys
195 200 205Glu Thr Ile Asn Met Ile Gly Ala Lys Glu Ile Glu Arg Met Lys Lys
210 215 220Gly Val Ile Leu Leu Asn Cys Ala Arg Gly Gly Leu Tyr Asn Glu Asp225 230 235 240Ala Leu Tyr Glu Ala Leu Glu Thr Lys Lys Val Arg Trp Leu Gly Ile
245 250 255Asp Val Phe Ser Lys Glu Pro Gly Ile His Asn Lys Leu Leu Asp Leu
260 265 270Pro Asn Val Tyr Ala Thr Pro His Ile Gly Ala Asn Thr Leu Glu Ser
275 280 285Gln Glu Glu Ile Ser Lys Gln Ala Ala Gln Gly Val Met Glu Ser Leu
290 295 300Arg Gly Ser Ser His Pro His Ala Leu Asn Leu Pro Met Gln Ala Phe305 310 315 320Asp Ala Ser Ala Lys Ala Tyr Leu Asn Leu Ala Gln Lys Leu Gly Tyr
325 330 335Phe Ser Ser Gln Ile His Lys Gly Val Cys Gln Lys Ile Glu Leu Ser
340 345 350Leu Cys Gly Glu Ile Asn Gln Phe Lys Asp Ala Leu Val Ala Phe Met
355 360 365Leu Val Gly Val Leu Lys Pro Val Val Gly Asp Lys Ile AsnTyr Ile
370 375 380Asn Ala Pro Phe Val Ala Lys Glu Arg Gly Ile Glu Ile Lys Val Ser385 390 395 400Leu Lys Glu Ser Ala Ser Pro Tyr Lys Asn Met Leu Ser Leu Thr Leu
405 410 415Asn Ala Ala Asn Gly Thr Ile Ser Val Ser Gly Thr Val Phe Glu Glu
420 425 430Asp Ile Leu Lys Leu Thr Glu Ile Asp Gly Phe His Ile Asp Ile Glu
435 440 445Pro Lys Gly Lys Met Leu Leu Phe Arg Asn Thr Asp Ile Pro Gly Val
450 455 460Ile Gly Ser Val Gly Asn Ala Phe Ala Arg His Gly Ile Asn Ile Ala465 470 475 480Asp Phe Arg Leu Gly Arg Asn Thr Gln Lys Glu Ala Leu Ala Leu Ile
485 490 495Ile Val Asp Glu Glu Val Ser Leu Glu Val Leu Glu Glu Leu Lys Asn
500 505 510Ile Pro Ala Cys Leu Ser Val His Tyr Val Val Ile
515520 (2) sequence 1297 data: (i) sequence characteristics: length (A): 1748bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1701 (D) other information: (xi) Description of the sequence: sequence 1297: GGATTTTATA TTTATTTTAT AGTAAGGCAG TCA ATG AGC AAG ATA GCA GAT GAT 54
Met Ser Lys Ile Ala Asp Asp
1 5CAG AAC TTT AAT GAC GAG GAG GAA AAC TTC GCA AAA CTC TTT AAA AAA 102Gln Asn Phe Asn Asp Glu Glu GluAsn Phe Ala Lys Leu Phe Lys Lys
10 15 20GAA TTA GAA AAA GAA GAA ACC CTA GAA AAA GGC ACT ATC AAA GAA GGG 150Glu Leu Glu Lys Glu Glu Thr Leu Glu Lys Gly Thr Ile Lys Glu Gly
25 30 35CTA GTC GTT TCC ATC AAT GAG AAT GAT GGT TAT GCC ATG GTG AGC GTG 198Leu Val Val Ser Ile Asn Glu Asn Asp Gly Tyr Ala Met Val Ser Val40 45 50 55GGC GGT AAG ACA GAA GGC CGT TTG GCT TTG AAT GAG ATC ACC GAT GAA 246Gly Gly Lys Thr Glu Gly Arg Leu Ala Leu Asn Glu Ile Thr Asp Glu
60 65 70AAG GGG CAG TTG CTG TAT CAA AAA AAT GAC CCC ATT ATC GTG CAT GTG 294Lys Gly Gln Leu Leu Tyr Gln Lys Asn Asp Pro Ile Ile Val His Val
75 80 85TCC GAA AAA GGT GAA CAC CCT AGC GTT TCC TAC AAA AAG GCC ATT TCC 342Ser Glu Lys Gly Glu His Pro Ser Val Ser Tyr Lys Lys Ala Ile Ser
90 95 100CAA CAA AAG ATT CAA GCT AAA ATT GAA GAA TTA GGC GAA AAC TAT GAA 390Gln Gln Lys Ile Gln Ala Lys Ile Glu Glu Leu Gly Glu Asn Tyr Glu
105 110 115AAC GCC ATT ATT GAA GGC AAG ATT GTA GGC AAG AAT AAA GGG GGT TAT 438Asn Ala Tle Ile Glu Gly Lys Ile Val Gly Lys Asn Lys Gly Gly Tyr120 125 130 135ATC GTG GAG TCT CAA GGC GTG GAG TAT TTC CTC TCC CGC TCG CAC TCT 486Ile Val Glu Ser Gln Gly Val Glu Tyr Phe Leu Ser Arg Ser His Ser
140 145 150TCT TTA AAG AAT GAC GCA AAC CAT ATC GGC AAA CGC GTT AAA GCG TGC 534Ser Leu Lys Asn Asp Ala Asn His Ile Gly Lys Arg Val Lys Ala Cys
155 160165ATC ATT CGT GTG GAT AAG GAA AAC CAT TCT ATC AAT ATT TCT CGC AAA 582Ile Ile Arg Val Asp Lys Glu Asn His Ser Ile Asn Ile Ser Arg Lys
170 175 180CGA TTC TTT GAA GTC AAT GAC AAA CGA CAA CTT GAG GTT TCT AAG GAA 630Arg Phe Phe Glu Val Asn Asp Lys Arg Gln Leu Glu Val Ser Lys Glu
185 190 195TTG TTA GAA GCC ACA GAG CCG GTG TTA GGG GTT GTG CGC CAG ATC ACC 678Leu Leu Glu Ala Thr Glu Pro Val Leu Gly Val Val Arg Gln Ile Thr200 205 210 215CCT TTT GGC ATT TTT GTA GAA GCT AAG GGG ATT GAG GGC TTG GTC CAT 726Pro Phe Gly Ile Phe Val Glu Ala Lys Gly Ile Glu Gly Leu Val His
220 225 230TAT TCT GAA ATC AGC CAT AAG GGA CCA GTC AAT CCT GAA AAA TAC TAC 774Tyr Ser Glu Ile Ser His Lys Gly Pro Val Asn Pro Glu Lys Tyr Tyr
235 240 245AAA GAG GGC GAT GAA GTC TAT GTC AAA GCC ATC GCT TAT GAT GCA GAA 822Lys Glu Gly Asp Glu Val Tyr Val Lys Ala Ile Ala Tyr Asp Ala Glu
250 255 260AAA AGA CGC CTT TCA CTC TCC ATA AAA GCG ACT ATA GAA GAC CCA TGG 870Lys Arg Arg Leu Ser Leu Ser Ile Lys Ala Thr Ile Glu Asp Pro Trp
265 270 275GAA GAG ATT CAA GAC AAG CTA AAA CCC GGA TAC GCC ATT AAG GTA GTG 918Glu Glu Ile Gln Asp Lys Leu Lys Pro Gly Tyr Ala Ile Lys Val Val280 285 290 295GTG AGC AAC ATT GAA CAT TAT GGG GTG TTT GTG GAT ATT GGT AAT GAT 966Val Ser Asn Ile Glu His Tyr Gly Val Phe Val Asp Ile Gly Asn Asp
300 305 310ATT GAA GGC TTT TTG CAT GTT TCT GAA ATC TCT TGG GAT AAA AAT GTC 1014Ile Glu Gly Phe Leu His Val Ser Glu Ile Ser Trp Asp Lys Asn Val
315 320 325AGC CAC CCT AAC AAT TAC TTG AGC GTG GGG CAA GAG ATT GAT GTG AAA 1062Ser His Pro Asn Asn Tyr Leu Ser Val Gly Gln Glu Ile Asp Val Lys
330 335 340ATC ATT GAC ATT GAT CCA AAA AAT CGC CGC TTA AGG GTT TCT TTA AAG 1110Ile Ile Asp Ile Asp Pro Lys Asn Arg Arg Leu Arg Val Ser Leu Lys
345 350 355CAA CTC ACT AAC AGG CCT TTT GAT GTT TTT GAA TCT AAA CAC CAA GTG 1158Gln Leu Thr Asn Arg Pro Phe Asp Val Phe Glu Ser Lys His Gln Val360 365 370 375GGG GAT GTT TTA GAA GGC AAA GTG GCG ACT TTA ACG GAT TTT GGG GCG 1206Gly Asp Val Leu Glu Gly Lys Val Ala Thr Leu Thr Asp Phe Gly Ala
380 385 390TTT TTA AAT CTG GGT GGG GTG GAT GGT TTG CTC CAC AAT CAC GAC GCT 1254Phe Leu Asn Leu Gly Gly Val Asp Gly Leu Leu His Asn His Asp Ala
395 400 405TTT TGG GAT AAA GAT AAA AAA TGC AAA GAC CAC TAT AAA ATT GGC GAT 1302Phe Trp Asp Lys Asp Lys Lys Cys Lys Asp His Tyr Lys Ile Gly Asp
410 415 420GTG ATC AAA GTG AAA ATC CTT AAA ATC AAC AAA AAA GAT AAA AAG ATT 1350Val Ile Lys Val Lys Ile Leu Lys Ile Asn Lys Lys Asp Lys Lys Ile
425 430 435TCT TTG AGC GCG AAG CAC TTG GTG ACT TCC CCT ACA GAA GAA TTC GCT 1398Ser Leu Ser Ala Lys His Leu Val Thr Ser Pro Thr Glu Glu Phe Ala440 445 450 455CAA AAG CAT AAA ACA GAC AGC GTG ATT CAA GGC AAA GTG GTG AGT ATT 1446Gln Lys His Lys Thr Asp Ser Val Ile Gln Gly Lys Val Val Ser Ile
460 465 470AAG GAT TTT GGC GTT TTC ATT AAT GCT GAT GGC ATT GAT GTG CTG ATC 1494Lys Asp Phe Gly Val Phe Ile Asn Ala Asp Gly Ile Asp Val Leu Ile
475 480 485AAA AAT GAA GAT TTG AAC CCC TTG AAA AAA GAT GAA ATT AAA ATA GGC 1542Lys Asn Glu Asp Leu Asn Pro Leu Lys Lys Asp Glu Ile Lys Ile Gly
490 495 500CAA GAA ATC ACA TGC GTG GTG GTT GCG ATT GAA AAA TCT AAC AAC AAG 1590Gln Glu Ile Thr Cys Val Val Val Ala Ile Glu Lys Ser Asn Asn Lys
505 510 515GTG CGT GCT TCT GTG CAT AGG TTA GAG CGC AAA AAA GAA AAA GAA GAA 1638Val Arg Ala Ser Val His Arg Leu Glu Arg Lys Lys Glu Lys Glu Glu520 525 530 535TTG CAA GCT TTT AAC ACG AGC GAT GAT AAA ATG ACT TTA GGG GAT ATT 1686Leu Gln Ala Phe Asn Thr Ser Asp Asp Lys Met Thr Leu Gly Asp Ile
540 545 550CTT AAA GAA AAA CTC TAAAGAGTGA TTTTAAAAGC ATGAGAATGG CATGAGATTT A 1742Leu Lys Glu Lys Leu
555AGGGTG 1748 (2) sequence 1298 data: (i) sequence characteristics: length (A): 556 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1298: met Ser Lys Ile Ala Asp Asp Gln Asn Phe Asn Asp Glu Glu Glu Asn 151015 Phe Ala Lys Leu Phe Lys Lys Glu Leu Glu Lys Glu Glu Thr Leu Glu
20 25 30Lys Gly Thr Ile Lys Glu Gly Leu Val Val Ser Ile Asn Glu Asn Asp
35 40 45Gly Tyr Ala Met Val Ser Val Gly Gly Lys Thr Glu Gly Arg Leu Ala
50 55 60Leu Asn Glu Ile Thr Asp Glu Lys Gly Gln Leu Leu Tyr Gln Lys Asn65 70 75 80Asp Pro Ile Ile Val His Val Ser Glu Lys Gly Glu His Pro Ser Val
85 90 95Ser Tyr Lys Lys Ala Ile Ser Gln Gln Lys Ile Gln Ala Lys Ile Glu
100 105 110Glu Leu Gly Glu Asn Tyr Glu Asn Ala Ile Ile Glu Gly Lys Ile Val
115 120 125Gly Lys Asn Lys Gly Gly Tyr Ile Val Glu Ser Gln Gly Val Glu Tyr
130 135 140Phe Leu Ser Arg Ser His Ser Ser Leu Lys Asn Asp Ala Asn His Ile145 150 155 160Gly Lys Arg Val Lys Ala Cys Ile Ile Arg Val Asp Lys Glu Asn His
165 170 175Ser Ile Asn Ile Ser Arg Lys Arg Phe Phe Glu Val Asn Asp Lys Arg
180 185 190Gln Leu Glu Val Ser Lys Glu Leu Leu Glu Ala Thr Glu Pro Val Leu
195 200 205Gly Val Val Arg Gln Ile Thr Pro Phe Gly Ile Phe Val Glu Ala Lys
210 215 220Gly Ile Glu Gly Leu Val His Tyr Ser Glu Ile Ser His Lys Gly Pro225 230 235 240Val Asn Pro Glu Lys Tyr Tyr Lys Glu Gly Asp Glu Val Tyr Val Lys
245 250 255Ala Ile Ala Tyr Asp Ala Glu Lys Arg Arg Leu Ser Leu Ser Ile Lys
260 265 270Ala Thr Ile Glu Asp Pro Trp Glu Glu Ile Gln Asp Lys Leu Lys Pro
275 280285Gly Tyr Ala Ile Lys Val Val Val Ser Asn Ile Glu His Tyr Gly Val
290 295 300Phe Val Asp Ile Gly Asn Asp Ile Glu Gly Phe Leu His Val Ser Glu305 310 315 320Ile Ser Trp Asp Lys Asn Val Ser His Pro Asn Asn Tyr Leu Ser Val
325 330 335Gly Gln Glu Ile Asp Val Lys Ile Ile Asp Ile Asp Pro Lys Asn Arg
340 345 350Arg Leu Arg Val Ser Leu Lys Gln Leu Thr Asn Arg Pro Phe Asp Val
355 360 365Phe Glu Ser Lys His Gln Val Gly Asp Val Leu Glu Gly Lys Val Ala
370 375 380Thr Leu Thr Asp Phe Gly Ala Phe Leu Asn Leu Gly Gly Val Asp Gly385 390 395 400Leu Leu His Asn His Asp Ala Phe Trp Asp Lys Asp Lys Lys Cys Lys
405 410 415Asp His Tyr Lys Ile Gly Asp Val Ile Lys Val Lys Ile Leu Lys Ile
420 425 430Asn Lys Lys Asp Lys Lys Ile Ser Leu Ser Ala Lys His Leu Val Thr
435 440 445Ser Pro Thr Glu Glu Phe Ala Gln Lys His Lys Thr Asp Ser Val Ile
450 455 460Gln Gly Lys Val Val Ser Ile Lys Asp Phe Gly Val Phe Ile Asn Ala465 470 475 480Asp Gly Ile Asp Val Leu Ile Lys Asn Glu Asp Leu Asn Pro Leu Lys
485 490 495Lys Asp Glu Ile Lys Ile Gly Gln Glu Ile Thr Cys Val Val Val Ala
500 505510Ile Glu Lys Ser Asn Asn Lys Val Arg Ala Ser Val His Arg Leu Glu
515 520 525Arg Lys Lys Glu Lys Glu Glu Leu Gln Ala Phe Asn Thr Ser Asp Asp
530535540 Lys Met Thr Leu Gly Asp Ile Leu Lys Glu Lys Leu 545550555 (2) sequence 1299 data: (i) sequence characteristics: length (A): 1636bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1584 (D) other information: (xi) Description of the sequence: sequence 1299: AATTTGGGGT GTTTTAACAG AATGCAAGCT TGAAGGAGAA TC ATG TCC ATT TCA 54
Met Ser Ile Ser
1CGC AGA AGT ATC CTA ACA AAA ATC CCA ATC GCG CTC GCT AGC GCT AAT 102Arg Arg Ser Ile Leu Thr Lys Ile Pro Ile Ala Leu Ala Ser Ala Asn 5 10 15 20GTT TTG AAA GCT GTT GGT GTT TTT GAA AAA GTA GAA TCC ATT CCG CAT 150Val Leu Lys Ala Val Gly Val Phe Glu Lys Val Glu Ser Ile Pro His
25 30 35GCA ACG CAT TTT GGC CCC TTT ATC GCA AAG GTT CAA AAT GGA GTG ATT 198Ala Thr His Phe Gly Pro Phe Ile Ala Lys Val Gln Asn Gly Val Ile
40 45 50AAA GAT ATT GTC CCC CAA AAA AGC GAT TAT AAC CCT ACT ATG ATG TTA 246Lys Asp Ile Val Pro Gln Lys Ser Asp Tyr Asn Pro Thr Met Met Leu
55 60 65AAA GCG ATG GTT GAT AGG GTG TAT TCA GAT AGT AGG GTG AAG TAT CCT 294Lys Ala Met Val Asp Arg Val Tyr Ser Asp Ser Arg Val Lys Tyr Pro
70 75 80TGC GTG CGC AAG AGC TTC TTA GAA AAC AAA AAA AACCAC AAA GAA TTG 342Cys Val Arg Lys Ser Phe Leu Glu Asn Lys Lys Asn His Lys Glu Leu85 90 95 100CGC GGG AGA GAA GAG TTT GTG CGT GTG AGT TGG GAT GTG GCG TTG GAT 390Arg Gly Arg Glu Glu Phe Val Arg Val Ser Trp Asp Val Ala Leu Asp
105 110 115TTA GCG GCT AAA AAG CTT AAA GAA ATC CCT AAA GAA AAC ATT TAT AAT 438Leu Ala Ala Lys Lys Leu Lys Glu Ile Pro Lys Glu Asn Ile Tyr Asn
120 125 130GCC AGT TAT GGT GGC TGG GGG CAT GCG GGC AGC TTG CAT CGT TGC CAT 486Ala Ser Tyr Gly Gly Trp Gly His Ala Gly Ser Leu His Arg Cys His
135 140 145CAT TTA GCA TGG CGT TTT TTT AAC ACG ACT TTA GGA GGG GCT ATT GGC 534His Leu Ala Trp Arg Phe Phe Asn Thr Thr Leu Gly Gly Ala Ile Gly
150 155 160ACT GAT GGG GAA TAT AGT AAT GGC GCG GCC GCA AGA ATA AAC CCT ATG 582Thr Asp Gly Glu Tyr Ser Asn Gly Ala Ala Ala Arg Ile Asn Pro Met165 170 175 180ATT GTA GGG GAT ATG GAA GTT TAT TCG CAA CAA ACC ACG CAT GAA GAG 630Ile Val Gly Asp Met Glu Val Tyr Ser Gln Gln Thr Thr His Glu Glu
185 190 195ATG ATT AAA AAT TGT AAG GTG TAT GTC ATG TGG GGG GCG GAT TTA CTC 678Met Ile Lys Asn Cys Lys Val Tyr Val Met Trp Gly Ala Asp Leu Leu
200 205 210AAG TGC AAC CGC ATT GAT TAT TTT GTG CCA AAC CAT GTC AAT GAC AGC 726Lys Cys Asn Arg Ile Asp Tyr Phe Val Pro Asn His Val Asn Asp Ser
215 220 225TAC TAC CCC AAG TAT AAA AGA GCT GGT ATT AAA TTC ATT AGT ATC GAT 774Tyr Tyr Pro Lys Tyr Lys Arg Ala Gly Ile Lys Phe IleSer Ile Asp
230 235 240CCC ATT TAT ACC GAA ACC GCT CAA GCC TTT AGT GCT GAA TGG ATA CCC 822Pro Ile Tyr Thr Glu Thr Ala Gln Ala Phe Ser Ala Glu Trp Ile Pro245 250 255 260ATT CGC CCT AAC ACT GAT GTA GCG TTA ATG CTA GGC ATG ATG CAT TAT 870Ile Arg Pro Asn Thr Asp Val Ala Leu Met Leu Gly Met Met His Tyr
265 270 275CTT TAT ACG AGC AAT CAA TAT GAT AAA GCG TTT ATC GCT AAA TAC ACT 918Leu Tyr Thr Ser Asn Gln Tyr Asp Lys Ala Phe Ile Ala Lys Tyr Thr
280 285 290GAT GGT TTT GAT AAA TTT TTA CCC TAT TTG CTA GGA GAG AGC GAT AAT 966Asp Gly Phe Asp Lys Phe Leu Pro Tyr Leu Leu Gly Glu Ser Asp Asn
295 300 305GCG CCT AAG ACT TTA GAA TGG GCG TCT CAA ATC ACT GGA GTG AGC GCA 1014Ala Pro Lys Thr Leu Glu Trp Ala Ser Gln Ile Thr Gly Val Ser Ala
310 315 320GAA AAA ATC AAA GAA TTA GCG GAT TTG TTT GTT TCT AAA CGC ACT TTT 1062Glu Lys Ile Lys Glu Leu Ala Asp Leu Phe Val Ser Lys Arg Thr Phe325 330 335 340TTA GCG GGT AAT TGG GCC ATG CAA AGA GCT CAG TAT GGC GAG CAA CCG 1110Leu Ala Gly Asn Trp Ala Met Gln Arg Ala Gln Tyr Gly Glu Gln Pro
345 350 355GAT TGG GCG TTA ATT GTT TTA GCT AGC ATG ATT GGT CAA GTG GGC TTA 1158Asp Trp Ala Leu Ile Val Leu Ala Ser Met Ile Gly Gln Val Gly Leu
360 365 370TCG GGT GGG GGC TTT GGC TTT TCT ATG CAT TAT GGA GGG AAC GCT CAA 1206Ser Gly Gly Gly Phe Gly Phe Ser Met His Tyr Gly Gly Asn Ala Gln
375 380 385GCA AGC TCA GGG GCA AGA ATT GTT CCT ATG ATT TCA CAA GGG CAT AAT 1254Ala Ser Ser Gly Ala Arg Ile Val Pro Met Ile Ser Gln Gly His Asn
390 395 400TCT GTA AAA AGC GTT ATT CCA GCA TCT AGG GTT TCT GAA GCG ATT TTA 1302Ser Val Lys Ser Val Ile Pro Ala Ser Arg Val Ser Glu Ala Ile Leu405 410 415 420AAT CCG GAT AAA GAA ATT GAT TTT ATG GGC AAA AAA CTC AAA TTG CCT 1350Asn Pro Asp Lys Glu Ile Asp Phe Met Gly Lys Lys Leu Lys Leu Pro
425 430 435AAA ATC AAA ATG ATT TAT AAT TGT GGG GCG GAT TTA TTA GGG CAT GAA 1398Lys Ile Lys Met Ile Tyr Asn Cys Gly Ala Asp Leu Leu Gly His Glu
440 445 450ACT GAT ACA AAC GAG CTG ATT CGC GCT TTA AGG ACC TTA GAT TGC GTG 1446Thr Asp Thr Asn Glu Leu Ile Arg Ala Leu Arg Thr Leu Asp Cys Val
455 460 465ATC GTG CAT GAG CCT TGG TGG CGC CTA CGG CAA AAT TTG CTG ATA TTG 1494Ile Val His Glu Pro Trp Trp Arg Leu Arg Gln Asn Leu Leu Ile Leu
470 475 480TCT TTG CTT CCA CTA GCA CTG TGG AAA GAG ATG ATA TTG CTT TTG GAG 1542Ser Leu Leu Pro Leu Ala Leu Trp Lys Glu Met Ile Leu Leu Leu Glu485 490 495 500GGA GTT ATT CTA AGA ATG TGG TTT ATG CCA TGC GTA AGG TGG TAGAGCCTG 1593Gly Val Ile Leu Arg Met Trp Phe Met Pro Cys Val Arg Trp
505510 TTTATGAATC TAAAGACGAT TATGAGATTT TCAGACAGCT TGC 1636 (2) sequence 1300 data: (i) sequence characteristics: length (A): 514 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1300: met Ser Ile Ser Arg Arg Ser Ile Leu Thr Lys Ile Pro Ile Ala Leu 151015 Ala Ser Ala Asn Val Leu Lys Ala Val Gly Val Phe Glu Lys Val Glu
20 25 30Ser Ile Pro His Ala Thr His Phe Gly Pro Phe Ile Ala Lys Val Gln
35 40 45Asn Gly Val Ile Lys Asp Ile Val Pro Gln Lys Ser Asp Tyr Asn Pro
50 55 60Thr Met Met Leu Lys Ala Met Val Asp Arg Val Tyr Ser Asp Ser Arg65 70 75 80Val Lys Tyr Pro Cys Val Arg Lys Ser Phe Leu Glu Asn Lys Lys Asn
85 90 95His Lys Glu Leu Arg Gly Arg Glu Glu Phe Val Arg Val Ser Trp Asp
100 105 110Val Ala Leu Asp Leu Ala Ala Lys Lys Leu Lys Glu Ile Pro Lys Glu
115 120 125Asn Ile Tyr Asn Ala Ser Tyr Gly Gly Trp Gly His Ala Gly Ser Leu
130 135 140His Arg Cys His His Leu Ala Trp Arg Phe Phe Asn Thr Thr Leu Gly145 150 155 160Gly Ala Ile Gly Thr Asp Gly Glu Tyr Ser Asn Gly Ala Ala Ala Arg
165 170 175Ile Asn Pro Met Ile Val Gly Asp Met Glu Val Tyr Ser Gln Gln Thr
180 185 190Thr His Glu Glu Met Ile Lys Asn Cys Lys Val Tyr Val Met Trp Gly
195 200 205Ala Asp Leu Leu Lys Cys Asn Arg Ile Asp Tyr Phe Val Pro Asn His
210 215 220Val Asn Asp Ser Tyr Tyr Pro Lys Tyr Lys Arg Ala Gly Ile Lys Phe225 230 235 240Ile Ser Ile Asp Pro Ile Tyr Thr Glu Thr Ala Gln Ala Phe Ser Ala
245 250 255Glu Trp Ile Pro Ile Arg Pro Asn Thr Asp Val Ala Leu Met Leu Gly
260 265 270Met Met His Tyr Leu Tyr Thr Ser Asn Gln Tyr Asp Lys Ala Phe Ile
275 280 285Ala Lys Tyr Thr Asp Gly Phe Asp Lys Phe Leu Pro Tyr Leu Leu Gly
290 295 300Glu Ser Asp Asn Ala Pro Lys Thr Leu Glu Trp Ala Ser Gln Ile Thr305 310 315 320Gly Val Ser Ala Glu Lys Ile Lys Glu Leu Ala Asp Leu Phe Val Ser
325 330 335Lys Arg Thr Phe Leu Ala Gly Asn Trp Ala Met Gln Arg Ala Gln Tyr
340 345 350Gly Glu Gln Pro Asp Trp Ala Leu Ile Val Leu Ala Ser Met Ile Gly
355 360 365Gln Val Gly Leu Ser Gly Gly Gly Phe Gly Phe Ser Met His Tyr Gly
370 375 380Gly Asn Ala Gln Ala Ser Ser Gly Ala Arg Ile Val Pro Met Ile Ser385 390 395 400Gln Gly His Asn Ser Val Lys Ser Val Ile Pro Ala Ser Arg Val Ser
405 410 415Glu Ala Ile Leu Asn Pro Asp Lys Glu Ile Asp Phe Met Gly Lys Lys
420 425 430Leu Lys Leu Pro Lys Ile Lys Met Ile Tyr Asn Cys Gly Ala Asp Leu
435 440 445Leu Gly His Glu Thr Asp Thr Asn Glu Leu Ile Arg Ala Leu Arg Thr
450 455460Leu Asp Cys Val Ile Val His Glu Pro Trp Trp Arg Leu Arg Gln Asn465 470 475 480Leu Leu Ile Leu Ser Leu Leu Pro Leu Ala Leu Trp Lys Glu Met Ile
485 490 495Leu Leu Leu Glu Gly Val Ile Leu Arg Met Trp Phe Met Pro Cys Val
500505510 Arg Trp (2) sequence 1301 data: (i) sequence characteristics: length (A): 540bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 509 (D) other information: (xi) Description of the sequence: sequence 1301: ATTGACGCTT ATAAGGATAA AAG ATG AAT ATT TTT CAA ACG AGT TTG AAA TGT 53
Met Asn Ile Phe Gln Thr Ser Leu Lys Cys
1 5 10TGC GTG GGG TTG GTT TTG TCT GTG GGG GTC TTA TTA GGG GAT TCT AAA 101Cys Val Gly Leu Val Leu Ser Val Gly Val Leu Leu Gly Asp Ser Lys
15 20 25GCT TTT AAG GTT AGG GTG GAT AAA AGT TTA ACC CCG CCT TTT TTG AAT 149Ala Phe Lys Val Arg Val Asp Lys Ser Leu Thr Pro Pro Phe Leu Asn
30 35 40GTG CTT TCA TTA GCT TTT AAA CAA GAC ATG AAA AAA GAG GTC ATT TTT 197Val Leu Ser Leu Ala Phe Lys Gln Asp Met Lys Lys Glu Val Ile Phe
45 50 55GTG ATT ACC AAA AGC AAT AAG TTG AGT AAA AAA GTG CTT TGT GAT TTT 245Val Ile Thr Lys Ser Asn Lys Leu Ser Lys Lys Val Leu Cys Asp Phe
60 65 70GAC GCT TTT TTA TTG CCT GAG ACT CTG ATG AGC GGC ATG CCT AAA AAA 293Asp Ala Phe Leu Leu Pro Glu Thr Leu Met Ser Gly Met Pro LysLys75 80 85 90GCA CTA TTC CAT AAA GAG TTT TTA TTC CAA TCT AAA GAA AAT AAA ACG 341Ala Leu Phe His Lys Glu Phe Leu Phe Gln Ser Lys Glu Asn Lys Thr
95 100 105CTC TAT GCG TTT TCG CTG ATT GAT TCT CAA TAT TGC TCA AAA GGT GGA 389Leu Tyr Ala Phe Ser Leu Ile Asp Ser Gln Tyr Cys Ser Lys Gly Gly
110 115 120AAT TAC AGA TAC GAA CTA GAA AAA TTA GAA CGC TGG TTT GTG CAA AAA 437Asn Tyr Arg Tyr Glu Leu Glu Lys Leu Glu Arg Trp Phe Val Gln Lys
125 130 135GCA CCT GAG TTG GCT GAA AGC TAT AGG GTG AAT TAC AAA AAT CAA TAC 485Ala Pro Glu Leu Ala Glu Ser Tyr Arg Val Asn Tyr Lys Asn Gln Tyr
140145150 AAT AAA ACA CAG ATC TCA CAA AAA TAAAGAATGA GCGATGATTT TAGTATTAGA 539Asn Lys Thr Gln Ile Ser Gln Lys 155160T 540 (2) sequence 1302 data: (i) sequence characteristics: length (A): 162 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1302: met Asn Ile Phe Gln Thr Ser Leu Lys Cys Cys Val Gly Leu Val Leu 151015 Ser Val Gly Val Leu Leu Gly Asp Ser Lys Ala Phe Lys Val Arg Val
20 25 30Asp Lys Ser Leu Thr Pro Pro Phe Leu Asn Val Leu Ser Leu Ala Phe
35 40 45Lys Gln Asp Met Lys Lys Glu Val Ile Phe Val Ile Thr Lys Ser Asn
50 55 60Lys Leu Ser Lys Lys Val Leu Cys Asp Phe Asp Ala Phe Leu Leu Pro65 70 75 80Glu Thr Leu Met Ser Gly Met Pro Lys Lys Ala Leu Phe His Lys Glu
85 9095Phe Leu Phe Gln Ser Lys Glu Asn Lys Thr Leu Tyr Ala Phe Ser Leu
100 105 110Ile Asp Ser Gln Tyr Cys Ser Lys Gly Gly Asn Tyr Arg Tyr Glu Leu
115 120 125Glu Lys Leu Glu Arg Trp Phe Val Gln Lys Ala Pro Glu Leu Ala Glu
130135140 Ser Tyr Arg Val Asn Tyr Lys Asn Gln Tyr Asn Lys Thr Gln Ile Ser 145150155160 Gln Lys (2) sequence 1303 data: (i) sequence characteristics: length (A): 1572bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1548 (D) other information: (xi) Description of the sequence: sequence 1303: TCTCACAAAA ATAAAGAATG AGCG ATG ATT TTA GTA TTA GAT TTT GGG AGT 51
Met Ile Leu Val Leu Asp Phe Gly Ser
1 5CAA TAC ACA CAG CTG ATT GCT AGA AGA TTG AGA GAG AGA GGG ATT TAT 99Gln Tyr Thr Gln Leu Ile Ala Arg Arg Leu Arg Glu Arg Gly Ile Tyr10 15 20 25ACA GAA ATA GTC CCT TTT TTT GAA AGC ATA GAA AAC ATT CAA AAA AAA 147Thr Glu Ile Val Pro Phe Phe Glu Ser Ile Glu Asn Ile Gln Lys Lys
30 35 40GCC CCC AAA GGT TTG ATT TTG AGT GGG GGG CCA GCG AGC GTG TAT GCT 195Ala Pro Lys Gly Leu Ile Leu Ser Gly Gly Pro Ala Ser Val Tyr Ala
45 50 55AAA GAC GCT TAC AAG CCT AGT GGG AAA ATC TTT GAT TTG AAT GTG CCG 243Lys Asp Ala Tyr Lys Pro Ser Gly Lys Ile Phe Asp Leu Asn Val Pro
60 65 70ATT TTA GGG ATT TGC TAC GGC ATG CAG TAT TTG GTG GAT TTT TTT GGG 291Ile Leu GlyIle Cys Tyr Gly Met Gln Tyr Leu Val Asp Phe Phe Gly
75 80 85 GGG GTA GTG GTT GGT GCG AAT GAG CAA GAA TTT GGT AAG GCT GTT TTA 339Gly Val Val Val Gly Ala Asn Glu Gln Glu Phe Gly Lys Ala Val Leu90 95 100 105GAA ATC ACT CAA AAT TCT GTG ATT TTT GAA GGC GTG AAG ATT AAA AGC 387Glu Ile Thr Gln Asn Ser Val Ile Phe Glu Gly Val Lys Ile Lys Ser
110 115 120CTT GTG TGG ATG AGC CAT ATG GAT AAA GTC ATA GAA CTG CCT AAA GGC 435Leu Val Trp Met Ser His Met Asp Lys Val Ile Glu Leu Pro Lys Gly
125 130 135TTT ACT ACC CTT GCA AAA AGC CCT AAT TCC CCC CAT TGC GCG ATT GAA 483Phe Thr Thr Leu Ala Lys Ser Pro Asn Ser Pro His Cys Ala Ile Glu
140 145 150AAC GGC AAG ATT TTT GGC TTG CAA TTC CAC CCA GAA GTC GTT CAA AGC 531Asn Gly Lys Ile Phe Gly Leu Gln Phe His Pro Glu Val Val Gln Ser
155 160 165GAA GAA GGG GGT AAG ATT TTA GAA AAT TTT GCC CTT TTA GTT TGC GGC 579Glu Glu Gly Gly Lys Ile Leu Glu Asn Phe Ala Leu Leu Val Cys Gly170 175 180 185TGT GAA AAA ACT TGG GGG ATG CAG CAT TTC GCT CAA AGA GAA ATC GCA 627Cys Glu Lys Thr Trp Gly Met Gln His Phe Ala Gln Arg Glu Ile Ala
190 195 200CGA TTG AAA GAA AAA ATC GCT AAC GCT AAG GTT TTG TGC GCG GTG AGT 675Arg Leu Lys Glu Lys Ile Ala Asn Ala Lys Val Leu Cys Ala Val Ser
205 210 215GGG GGC GTG GAT TCT ACG GTG GTC GCT ACG CTG TTG CAC AGA GCC ATT 723Gly Gly Val Asp Ser Thr Val Val Ala Thr Leu Leu His Arg Ala Ile
220 225 230AAG GAT AAT TTG ATC GCT GTT TTT GTG GAT CAT GGC TTG TTG CGT AAA 771Lys Asp Asn Leu Ile Ala Val Phe Val Asp His Gly Leu Leu Arg Lys
235 240 245AAT GAA AAA GAA AGG GTG CAA GCG ATG TTT AAG GAC TTG AAA ATC CCT 819Asn Glu Lys Glu Arg Val Gln Ala Met Phe Lys Asp Leu Lys Ile Pro250 255 260 265TTA AAC ACG ATA GAC GCT AAA GAA GTC TTT TTG TCT AAA TTA AAG GGC 867Leu Asn Thr Ile Asp Ala Lys Glu Val Phe Leu Ser Lys Leu Lys Gly
270 275 280GTG AGC GAG CCT GAA TTG AAG CGA AAA ATC ATC GGC GAG ACC TTT ATT 915Val Ser Glu Pro Glu Leu Lys Arg Lys Ile Ile Gly Glu Thr Phe Ile
285 290 295GAA GTG TTT GAA AAA GAA GCC AAA AAG CAC CAT TTA AAA GGC AAA ATT 963Glu Val Phe Glu Lys Glu Ala Lys Lys His His Leu Lys Gly Lys Ile
300 305 310GAA TTT TTA GCC CAA GGC ACT TTA TAC CCT GAT GTG ATT GAA TCC GTG 1011Glu Phe Leu Ala Gln Gly Thr Leu Tyr Pro Asp Val Ile Glu Ser Val
315 320 325AGC GTT AAA GGG CCT TCA AAA GTG ATC AAA ACC CAT CAT AAT GTG GGC 1059Ser Val Lys Gly Pro Ser Lys Val Ile Lys Thr His His Asn Val Gly330 335 340 345GGA CTG CCT GAA TGG ATG GAT TTT AAA CTC ATA GAG CCT TTA AGG GAG 1107Gly Leu Pro Glu Trp Met Asp Phe Lys Leu Ile Glu Pro Leu Arg Glu
350 355 360TTG TTT AAA GAT GAG GTG CGC TTA CTG GGT AAA GAA TTG GGC GTT AGT 1155Leu Phe Lys Asp Glu Val Arg Leu Leu Gly Lys Glu Leu Gly Val Ser
365 370 375CAG GAT TTT TTA ATGCGC CAC CCT TTT CCA GGG CCT GGG CTT GCT GTA 1203Gln Asp Phe Leu Met Arg His Pro Phe Pro Gly Pro Gly Leu Ala Val
380 385 390AGG ATT TTA GGC GAA ATC AGT GAG AGT AAG ATC AAA CGC TTG CAA GAA 1251Arg Ile Leu Gly Glu Ile Ser Glu Ser Lys Ile Lys Arg Leu Gln Glu
395 400 405GCG GAT TTT ATT TTT ATA GAG GAA CTT AAA AAA GCC AAT TTG TAT GAC 1299Ala Asp Phe Ile Phe Ile Glu Glu Leu Lys Lys Ala Asn Leu Tyr Asp410 415 420 425AAG GTT TGG CAA GCT TTT TGC GTG CTG TTG AAT GTC AAT TCT GTG GGG 1347Lys Val Trp Gln Ala Phe Cys Val Leu Leu Asn Val Asn Ser Val Gly
430 435 440GTT ATG GGG GAT AAC CGC ACT TAT GAA AAC GCT ATT TGC TTA AGA GCG 1395Val Met Gly Asp Asn Arg Thr Tyr Glu Asn Ala Ile Cys Leu Arg Ala
445 450 455GTA AAT GCG AGC GAT GGC ATG ACG GCG AGC TTT TCA TTT TTA GAG CAT 1443Val Asn Ala Ser Asp Gly Met Thr Ala Ser Phe Ser Phe Leu Glu His
460 465 470TCT TTT TTA GAA AAG GTT TCT AAC CGT ATC ACT AAT GAA GTG AGC GGT 1491Ser Phe Leu Glu Lys Val Ser Asn Arg Ile Thr Asn Glu Val Ser Gly
475480485 ATC AAT AGG GTG GTG TAT GAC ATT ACC TCT AAA CCA CCA GGA ACG ATT 1539Ile Asn Arg Val Val Tyr Asp Ile Thr Ser Lys Pro Pro Gly Thr Ile 490495500505 GAA TGG GAA TGATTATCTT AAAAAATAGC ACTA 1572Glu Trp Glu (2) sequence 1304 data: (i) sequence characteristics: length (A): 508 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1304: met Ile Leu Val Leu Asp Phe Gly Ser Gln Tyr Thr Gln Leu Ile Ala 151015 Arg Arg Leu Arg Glu Arg Gly Ile Tyr Thr Glu Ile Val Pro Phe Phe
20 25 30Glu Ser Ile Glu Asn Ile Gln Lys Lys Ala Pro Lys Gly Leu Ile Leu
35 40 45Ser Gly Gly Pro Ala Ser Val Tyr Ala Lys Asp Ala Tyr Lys Pro Ser
50 55 60Gly Lys Ile Phe Asp Leu Asn Val Pro Ile Leu Gly Ile Cys Tyr Gly65 70 75 80Met Gln Tyr Leu Val Asp Phe Phe Gly Gly Val Val Val Gly Ala Asn
85 90 95Glu Gln Glu Phe Gly Lys Ala Val Leu Glu Ile Thr Gln Asn Ser Val
100 105 110Ile Phe Glu Gly Val Lys Ile Lys Ser Leu Val Trp Met Ser His Met
115 120 125Asp Lys Val Ile Glu Leu Pro Lys Gly Phe Thr Thr Leu Ala Lys Ser
130 135 140Pro Asn Ser Pro His Cys Ala Ile Glu Asn Gly Lys Ile Phe Gly Leu145 150 155 160Gln Phe His Pro Glu Val Val Gln Ser Glu Glu Gly Gly Lys Ile Leu
165 170 175Glu Asn Phe Ala Leu Leu Val Cys Gly Cys Glu Lys Thr Trp Gly Met
180 185 190Gln His Phe Ala Gln Arg Glu Ile Ala Arg Leu Lys Glu Lys Ile Ala
195 200 205Asn Ala Lys Val Leu Cys Ala Val Ser Gly Gly Val Asp Ser Thr Val
210 215 220Val Ala Thr Leu Leu His Arg Ala Ile Lys Asp Asn Leu Ile Ala Val225 230 235 240Phe Val Asp His Gly Leu Leu Arg Lys Asn Glu Lys Glu Arg Val Gln
245 250 255Ala Met Phe Lys Asp Leu Lys Ile Pro Leu Asn Thr Ile Asp Ala Lys
260 265 270Glu Val Phe Leu Ser Lys Leu Lys Gly Val Ser Glu Pro Glu Leu Lys
275 280 285Arg Lys Ile Ile Gly Glu Thr Phe Ile Glu Val Phe Glu Lys Glu Ala
290 295 300Lys Lys His His Leu Lys Gly Lys Ile Glu Phe Leu Ala Gln Gly Thr305 310 315 320Leu Tyr Pro Asp Val Ile Glu Ser Val Ser Val Lys Gly Pro Ser Lys
325 330 335Val Ile Lys Thr His His Asn Val Gly Gly Leu Pro Glu Trp Met Asp
340 345 350Phe Lys Leu Ile Glu Pro Leu Arg Glu Leu Phe Lys Asp Glu Val Arg
355 360 365Leu Leu Gly Lys Glu Leu Gly Val Ser Gln Asp Phe Leu Met Arg His
370 375 380Pro Phe Pro Gly Pro Gly Leu Ala Val Arg Ile Leu Gly Glu Ile Ser385 390 395 400Glu Ser Lys Ile Lys Arg Leu Gln Glu Ala Asp Phe Ile Phe Ile Glu
405 410 415Glu Leu Lys Lys Ala Asn Leu Tyr Asp Lys Val Trp Gln Ala Phe Cys
420 425 430Val Leu Leu Asn Val Asn Ser Val Gly Val Met Gly Asp Asn Arg Thr
435 440 445Tyr Glu Asn Ala Ile Cys Leu Arg Ala Val Asn Ala Ser Asp Gly Met
450 455 460Thr Ala Ser Phe Ser Phe Leu Glu His Ser Phe Leu Glu Lys Val Ser465470 475 480Asn Arg Ile Thr Asn Glu Val Ser Gly Ile Asn Arg Val Val Tyr Asp
485 490 495Ile Thr Ser Lys Pro Pro Gly Thr Ile Glu Trp Glu
500505 (2) sequence 1305 data: (i) sequence characteristics: length (A): 834bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 808 (D) other information: (xi) Description of the sequence: sequence 1305: AAAAACCCCC ACGCTATGGT AAATC ATG CTC ATT TGT AAC GAT AAA TCC AAT 52
Met Leu Ile Cys Asn Asp Lys Ser Asn
1 5CCA AAA ACC CTT TTA GAA GAA ATC ATG GCG TTA AGG CCA TGG CGT AAA 100Pro Lys Thr Leu Leu Glu Glu Ile Met Ala Leu Arg Pro Trp Arg Lys10 15 20 25GGC CCT TTT GAA ATT TCT CAA ATC AAG ATT GAT AGC GAA TGG GAT AGC 148Gly Pro Phe Glu Ile Ser Gln Ile Lys Ile Asp Ser Glu Trp Asp Ser
30 35 40TCC ATT AAA TGG GAT CTA GTT AAA AAC GCC ACT CCT TTA AAA GAT AAG 196Ser Ile Lys Trp Asp Leu Val Lys Asn Ala Thr Pro Leu Lys Asp Lys
45 50 55GTT GTG GCT GAT GTG GGT TGC AAT AAC GGC TAT TAC TTG TTT AAA ATG 244Val Val Ala Asp Val Gly Cys Asn Asn Gly Tyr Tyr Leu Phe Lys Met
60 65 70CTA GAA CAT GGG CCT AAA AGT TTG GTG GGG TTT GAT CCG GGC GTT TTA 292Leu Glu His Gly Pro Lys Ser Leu Val Gly Phe Asp Pro Gly Val Leu
75 80 85GTC AAA AAA CAA TTT GAA TTT TTA GCC CCC TTT TTT GAT AAA GAA AAA 340Val LysLys Gln Phe Glu Phe Leu Ala Pro Phe Phe Asp Lys Glu Lys90 95 100 105AAA ATC ATT TAT GAG TCT TTG GGG GTA GAG GAT TTG CAT GAA AAA TAC 388Lys Ile Ile Tyr Glu Ser Leu Gly Val Glu Asp Leu His Glu Lys Tyr
110 115 120CCT AAC GCT TTT GAT GTC ATT TTT TGC TTA GGG GTG CTA TAC CAC AGA 436Pro Asn Ala Phe Asp Val Ile Phe Cys Leu Gly Val Leu Tyr His Arg
125 130 135AAA AGC CCG CTA GAG GCT TTA AAA GCC TTG TAT CAC GCT TTG AAA ATA 484Lys Ser Pro Leu Glu Ala Leu Lys Ala Leu Tyr His Ala Leu Lys Ile
140 145 150AAA GGG GAG CTG GTG TTG GAT ACC TTA ATC ATT GAT TCG CCC TTA GAC 532Lys Gly Glu Leu Val Leu Asp Thr Leu Ile Ile Asp Ser Pro Leu Asp
155 160 165ATC GCC CTT TGC CCT AAA AAA ACT TAT GCT AAA ATG AAA AAT GTT TAT 580Ile Ala Leu Cys Pro Lys Lys Thr Tyr Ala Lys Met Lys Asn Val Tyr170 175 180 185TTT ATC CCC AGT GTT AGC GCG TTA AAA GGG TGG TGC GAA AGG GTA GGG 628Phe Ile Pro Ser Val Ser Ala Leu Lys Gly Trp Cys Glu Arg Val Gly
190 195 200TTT GAA AAT TTT GAG ATT CTT AGC GTT TTA AAG ACC ACG CCT AAA GAA 676Phe Glu Asn Phe Glu Ile Leu Ser Val Leu Lys Thr Thr Pro Lys Glu
205 210 215CAG CGT AAA ACG GAT TTT ATT TTG GGG CAG AGT TTG GAA GAT TTT TTG 724Gln Arg Lys Thr Asp Phe Ile Leu Gly Gln Ser Leu Glu Asp Phe Leu
220 225 230GAT AAA ACA GAT CCC TCT AAA ACT TTA GAG GGG TAT GAC GCC CCT TTA 772Asp Lys Thr Asp Pro Ser Lys Thr Leu Glu Gly Tyr Asp Ala Pro Leu
235240245 AGG GGG TAT TTT AAA ATG CTT AAA CCA AGC AAG CGT TAAATAAAGG ATTAAG 824Arg Gly Tyr Phe Lys Met Leu Lys Pro Ser Lys Arg 250255260 ATAGTGCAAG 834 (2) sequence 1306 data: (i) sequence characteristics: length (A): 261 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1306: met Leu Ile Cys Asn Asp Lys Ser Asn Pro Lys Thr Leu Leu Glu Glu 151015 Ile Met Ala Leu Arg Pro Trp Arg Lys Gly Pro Phe Glu Ile Ser Gln
20 25 30Ile Lys Ile Asp Ser Glu Trp Asp Ser Ser Ile Lys Trp Asp Leu Val
35 40 45Lys Asn Ala Thr Pro Leu Lys Asp Lys Val Val Ala Asp Val Gly Cys
50 55 60Asn Asn Gly Tyr Tyr Leu Phe Lys Met Leu Glu His Gly Pro Lys Ser65 70 75 80Leu Val Gly Phe Asp Pro Gly Val Leu Val Lys Lys Gln Phe Glu Phe
85 90 95Leu Ala Pro Phe Phe Asp Lys Glu Lys Lys Ile Ile Tyr Glu Ser Leu
100 105 110Gly Val Glu Asp Leu His Glu Lys Tyr Pro Asn Ala Phe Asp Val Ile
115 120 125Phe Cys Leu Gly Val Leu Tyr His Arg Lys Ser Pro Leu Glu Ala Leu
130 135 140Lys Ala Leu Tyr His Ala Leu Lys Ile Lys Gly Glu Leu Val Leu Asp145 150 155 160Thr Leu Ile Ile Asp Ser Pro Leu Asp Ile Ala Leu Cys Pro Lys Lys
165 170 175Thr Tyr Ala Lys Met Lys Asn Val Tyr Phe Ile Pro Ser Val Ser Ala
180185 190Leu Lys Gly Trp Cys Glu Arg Val Gly Phe Glu Asn Phe Glu Ile Leu
195 200 205Ser Val Leu Lys Thr Thr Pro Lys Glu Gln Arg Lys Thr Asp Phe Ile
210 215 220Leu Gly Gln Ser Leu Glu Asp Phe Leu Asp Lys Thr Asp Pro Ser Lys225 230 235 240Thr Leu Glu Gly Tyr Asp Ala Pro Leu Arg Gly Tyr Phe Lys Met Leu
245 250 255Lys Pro Ser Lys Arg
260(2) sequence 1307 data: (i) sequence characteristics: length (A): 1224bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1197 (D) other information: (xi) Description of the sequence: sequence 1307: TTAAATTCAA TTTTAAAGAA GAGTAGTTAA ATG GTT ATT GTT TTA GTC GTG GAT 54
Met Val Ile Val Leu Val Val Asp
1 5AGT TTT AAA GAC ACC AGT AAT GGC ACT TCT ATG ACA GCG TTT CGT TTT 102Ser Phe Lys Asp Thr Ser Asn Gly Thr Ser Met Thr Ala Phe Arg Phe
10 15 20TTT GAA GCG CTG AAA AAA AGA GGG CAT GTG ATG AGA GTG GTC GCC CCT 150Phe Glu Ala Leu Lys Lys Arg Gly His Val Met Arg Val Val Ala Pro25 30 35 40CAT GTG GAT AAT TTA GGG AGT GAA GAA GAG GGG TAT TAC AAC CTT AAA 198His Val Asp Asn Leu Gly Ser Glu Glu Glu Gly Tyr Tyr Asn Leu Lys
45 50 55GAG CGC TAC ATC CCC CTA GTT ACA GAA ATT TCA CAC AAA CAA CAC ATC 246Glu Arg Tyr Ile Pro Leu Val Thr Glu Ile Ser His Lys Gln His Ile
60 65 70CTT TTT GCT AAA CCC GAT GAA AAA ATC TTA AGA AAG GCT TTT AAG GGA 294Leu Phe Ala Lys Pro Asp Glu Lys Ile Leu Arg Lys Ala Phe Lys Gly
75 80 85GCG GAT ATG ATC CAT ACT TAT TTG CCT TTT TTG CTA GAA AAA ACA GCC 342Ala Asp Met Ile His Thr Tyr Leu Pro Phe Leu Leu Glu Lys Thr Ala
90 95 100GTA AAA ATC GCG CGA GAA ATG CAA GTG CCT TAT ATT GGC TCT TTC CAT 390Val Lys Ile Ala Arg Glu Met Gln Val Pro Tyr Ile Gly Ser Phe His105 110 115 120TTA CAG CCA GAG CAT ATT TCT TAT AAC ATG AAA TTG GGG TGG TTT TCT 438Leu Gln Pro Glu His Ile Ser Tyr Asn Met Lys Leu Gly Trp Phe Ser
125 130 135TGG TTC AAC ATG ATG CTT TTT TCG TGG TTT AAA TCT TCG CAT TAC CGC 486Trp Phe Asn Met Met Leu Phe Ser Trp Phe Lys Ser Ser His Tyr Arg
140 145 150TAT ATC CAC CAT ATC CAT TGC CCG TCA AAA TTC ATT GTA GAA GAA TTA 534Tyr Ile His His Ile His Cys Pro Ser Lys Phe Ile Val Glu Glu Leu
155 160 165GAA AAA TAC AAC TAT GGA GGG AAA AAA TAC GCT ATT TCT AAC GGC TTT 582Glu Lys Tyr Asn Tyr Gly Gly Lys Lys Tyr Ala Ile Ser Asn Gly Phe
170 175 180GAT CCC ATG TTT AGA TTT GAA CAC CCG CAA AAA AGC CTT TTT GAC ACC 630Asp Pro Met Phe Arg Phe Glu His Pro Gln Lys Ser Leu Phe Asp Thr185 190 195 200ACA CCC TTT AAA ATC GCT ATG GTA GGA CGC TAT TCT AAT GAA AAA AAT 678Thr Pro Phe Lys Ile Ala Met Val Gly Arg Tyr Ser Asn Glu Lys Asn
205 210 215CAA AGC GTT TTA ATC AAA GCG GTT GCT TTA AGC AAA TAC AAA CAA GAT 726Gln Ser Val Leu Ile Lys Ala Val Ala Leu Ser Lys Tyr Lys Gln Asp
220 225 230ATT GTA TTA TTG CTC AAA GGC AAA GGG CCT GAT GAG AAA AAA ATC AAA 774Ile Val Leu Leu Leu Lys Gly Lys Gly Pro Asp Glu Lys Lys Ile Lys
235 240 245CTT TTA GCC CAA AAA CTA GGC GTA AAA GCG GAG TTT GGG TTT GTC AAT 822Leu Leu Ala Gln Lys Leu Gly Val Lys Ala Glu Phe Gly Phe Val Asn
250 255 260TCC AAT GAA TTG TTA GAG ATC TTA AAA ACT TGC ACC CTT TAT GTG CAT 870Ser Asn Glu Leu Leu Glu Ile Leu Lys Thr Cys Thr Leu Tyr Val His265 270 275 280GCA GCC AAT GTG GAA AGC GAA GCG ATT GCG TGC TTA GAG GCC ATT AGC 918Ala Ala Asn Val Glu Ser Glu Ala Ile Ala Cys Leu Glu Ala Ile Ser
285 290 295GTG GGG ATT GTG CCT GTT ATC GCT AAT AGC CCT TTA AGC GCG ACC AGG 966Val Gly Ile Val Pro Val Ile Ala Asn Ser Pro Leu Ser Ala Thr Arg
300 305 310CAA TTT GCG CTA GAT GAA CGA TCG CTA TTT GAA CCT AAT AAC GCT AAA 1014Gln Phe Ala Leu Asp Glu Arg Ser Leu Phe Glu Pro Asn Asn Ala Lys
315 320 325GAT TTG AGC GCT AAA ATA GAT TGG TGG TTA GAA AAC AAG CTT GAA AGA 1062Asp Leu Ser Ala Lys Ile Asp Trp Trp Leu Glu Asn Lys Leu Glu Arg
330 335 340GAA AGG ATG CAA AAC GAA TAC GCT AAA AGC GCT TTA AAT TAC ACT TTA 1110Glu Arg Met Gln Asn Glu Tyr Ala Lys Ser Ala Leu Asn Tyr Thr Leu345 350 355 360GAA AAT TCA GTC ATT CAA ATT GAA AAA GTT TAT GAA GAA GCG ATC AGA 1158Glu Asn Ser ValIle Gln Ile Glu Lys Val Tyr Glu Glu Ala Ile Arg
365 370 375GAT TTT AAA AAT AAC CCC CAT CTC TTT AAA ACC TTA TCA TAATGAAAGG AT 1209Asp Phe Lys Asn Asn Pro His Leu Phe Lys Thr Leu Ser
380385 AAAAAATGCA AGAAG 1224, (2) sequence 1308 data: (i) sequence characteristics: length (A): 389 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1308: met Val Ile Val Leu Val Val Asp Ser Phe Lys Asp Thr Ser Asn Gly 151015 Thr Ser Met Thr Ala Phe Arg Phe Phe Glu Ala Leu Lys Lys Arg Gly
20 25 30His Val Met Arg Val Val Ala Pro His Val Asp Asn Leu Gly Ser Glu
35 40 45Glu Glu Gly Tyr Tyr Asn Leu Lys Glu Arg Tyr Ile Pro Leu Val Thr
50 55 60Glu Ile Ser His Lys Gln His Ile Leu Phe Ala Lys Pro Asp Glu Lys65 70 75 80Ile Leu Arg Lys Ala Phe Lys Gly Ala Asp Met Ile His Thr Tyr Leu
85 90 95Pro Phe Leu Leu Glu Lys Thr Ala Val Lys Ile Ala Arg Glu Met Gln
100 105 110Val Pro Tyr Ile Gly Ser Phe His Leu Gln Pro Glu His Ile Ser Tyr
115 120 125Asn Met Lys Leu Gly Trp Phe Ser Trp Phe Asn Met Met Leu Phe Ser
130 135 140Trp Phe Lys Ser Ser His Tyr Arg Tyr Ile His His Ile His Cys Pro145 150 155 160Ser Lys Phe Ile Val Glu Glu Leu Glu Lys Tyr Asn Tyr Gly Gly Lys
165 170 175Lys Tyr Ala Ile Ser Asn Gly Phe Asp Pro Met Phe Arg Phe Glu His
180 185 190Pro Gln Lys Ser Leu Phe Asp Thr Thr Pro Phe Lys Ile Ala Met Val
195 200 205Gly Arg Tyr Ser Asn Glu Lys Asn Gln Ser Val Leu Ile Lys Ala Val
210 215 220Ala Leu Ser Lys Tyr Lys Gln Asp Ile Val Leu Leu Leu Lys Gly Lys225 230 235 240Gly Pro Asp Glu Lys Lys Ile Lys Leu Leu Ala Gln Lys Leu Gly Val
245 250 255Lys Ala Glu Phe Gly Phe Val Asn Ser Asn Glu Leu Leu Glu Ile Leu
260 265 270Lys Thr Cys Thr Leu Tyr Val His Ala Ala Asn Val Glu Ser Glu Ala
275 280 285Ile Ala Cys Leu Glu Ala Ile Ser Val Gly Ile Val Pro Val Ile Ala
290 295 300Asn Ser Pro Leu Ser Ala Thr Arg Gln Phe Ala Leu Asp Glu Arg Ser305 310 315 320Leu Phe Glu Pro Asn Asn Ala Lys Asp Leu Ser Ala Lys Ile Asp Trp
325 330 335Trp Leu Glu Asn Lys Leu Glu Arg Glu Arg Met Gln Asn Glu Tyr Ala
340 345 350Lys Ser Ala Leu Asn Tyr Thr Leu Glu Asn Ser Val Ile Gln Ile Glu
355 360 365Lys Val Tyr Glu Glu Ala Ile Arg Asp Phe Lys Asn Asn Pro His Leu
370375380 Phe Lys Thr Leu Ser385 (2) sequence 1309 data: (i) sequence characteristics: length (A): 947bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 903 (D) other information: (xi) Description of the sequence: sequence 1309: TAGAAAAGGT AGTTT ATG GAG TTA GAA GAA ATT GTT GAT AGT GAG AGG AAT 51
Met Glu Leu Glu Glu Ile Val Asp Ser Glu Arg Asn
1 5 10ATC CAT AAG ACT ATA GAA GTT TTA GGA AAA GGC GGA CAG GGT ATA GTG 99Ile His Lys Thr Ile Glu Val Leu Gly Lys Gly Gly Gln Gly Ile Val
15 20 25TAT CGC TGT TTG GAT AAG GAT GTG GCT ATT AAG GTA GTA TTG AGG GAT 147Tyr Arg Cys Leu Asp Lys Asp Val Ala Ile Lys Val Val Leu Arg Asp
30 35 40GGA GAT TTT ATT AAA GAC AAA GAA TCC CTC AAA CAA TAT GAA AAA AGC 195Gly Asp Phe Ile Lys Asp Lys Glu Ser Leu Lys Gln Tyr Glu Lys Ser45 50 55 60GTT CTA AAC TTA TCT TTT AAG CCG ATA GAG AGT CAT TTC CCT ATG TCA 243Val Leu Asn Leu Ser Phe Lys Pro Ile Glu Ser His Phe Pro Met Ser
65 70 75ATT CCA CTG GTA ACT TTG AAA GAA AAA CAA GGC TAT GTG ATG AAA ATG 291Ile Pro Leu Val Thr Leu Lys Glu Lys Gln Gly Tyr Val Met Lys Met
80 85 90GCT GAG GGC TAT GAA CCA CTA AAA ACT TTT TTA AAG AAG CCC AGC ATT 339Ala Glu Gly Tyr Glu Pro Leu Lys Thr Phe Leu Lys Lys Pro Ser Ile
95 100 105TTA GAA AAC GAA GAA AAA GAT GGG ATT TTT AGG ATC AAT AAT GCC ATT 387Leu Glu Asn Glu Glu Lys Asp Gly Ile Phe Arg Ile Asn Asn Ala Ile
110 115 120CAA GAA CTT TGC AAA GAT AACCAT TAT ATG ACT TTA AGT TTA AGT TAT 435Gln Glu Leu Cys Lys Asp Asn His Tyr Met Thr Leu Ser Leu Ser Tyr125 130 135 140TAC TCA CAA ACA CAA GGA TTG AGA TCA CGA TTA AAA ATA CTC ACC CAT 483Tyr Ser Gln Thr Gln Gly Leu Arg Ser Arg Leu Lys Ile Leu Thr His
145 150 155TTA GCA AAA CTT CTA TTC AGA TTG CAA AGT AAG GGT TTG GTG TAT GGG 531Leu Ala Lys Leu Leu Phe Arg Leu Gln Ser Lys Gly Leu Val Tyr Gly
160 165 170GAC TTG AAT TTA AAC AAT GTT TTT TAT AAA GAC AAT TCA GCG TTT TTA 579Asp Leu Asn Leu Asn Asn Val Phe Tyr Lys Asp Asn Ser Ala Phe Leu
175 180 185ATT GAT GCG GAT AAT GTG CGT TAT GAG AGC GAA AAA GCC CTG TGT GTT 627Ile Asp Ala Asp Asn Val Arg Tyr Glu Ser Glu Lys Ala Leu Cys Val
190 195 200ATT TTT ACG CCT AAC TAT GGG GCT TTA GAG ATT AGC CAA ACC TCT AAA 675Ile Phe Thr Pro Asn Tyr Gly Ala Leu Glu Ile Ser Gln Thr Ser Lys205 210 215 220AAT AGC GAT ACA ACC AAT TAC AAC ACC ATG CTT AGC GAT ACC TTT TCT 723Asn Ser Asp Thr Thr Asn Tyr Asn Thr Met Leu Ser Asp Thr Phe Ser
225 230 235TTT GCT ATC ATA ACT TAT GAA CTT TTA AAT ATG GTT CAT CCT TTT GAT 771Phe Ala Ile Ile Thr Tyr Glu Leu Leu Asn Met Val His Pro Phe Asp
240 245 250GGG AAT AAG GCA GAT GAT AGT GTA GAA AAT TTT ATA GAA TTG CCT TGG 819Gly Asn Lys Ala Asp Asp Ser Val Glu Asn Phe Ile Glu Leu Pro Trp
255 260 265ATT GAA GAT AGA AAG GAT GAT AGC AAT CGT TCT TGT GGC TTA CTG CCT 867Ile Glu Asp Arg Lys Asp Asp SerAsn Arg Ser Cys Gly Leu Leu Pro
270275280 TTT TTC TTA ACA AGG GAT TTA AAA AAT TTA TTA GCG TAATGCTTTG AAGAAG 919Phe Phe Leu Thr Arg Asp Leu Lys Asn Leu Leu Ala 285290295 GCAAAAAAGA TCCTTTGAAA CGCCCTAC 947 (2) sequence 1310 data: (i) sequence characteristics: length (A): 296 amino acid (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1310: met Glu Leu Glu Glu Ile Val Asp Ser Glu Arg Asn Ile His Lys Thr 151015 Ile Glu Val Leu Gly Lys Gly Gly Gln Gly Ile Val Tyr Arg Cys Leu
20 25 30Asp Lys Asp Val Ala Ile Lys Val Val Leu Arg Asp Gly Asp Phe Ile
35 40 45Lys Asp Lys Glu Ser Leu Lys Gln Tyr Glu Lys Ser Val Leu Asn Leu
50 55 60Ser Phe Lys Pro Ile Glu Ser His Phe Pro Met Ser Ile Pro Leu Val65 70 75 80Thr Leu Lys Glu Lys Gln Gly Tyr Val Met Lys Met Ala Glu Gly Tyr
85 90 95Glu Pro Leu Lys Thr Phe Leu Lys Lys Pro Ser Ile Leu Glu Asn Glu
100 105 110Glu Lys Asp Gly Ile Phe Arg Ile Asn Asn Ala Ile Gln Glu Leu Cys
115 120 125Lys Asp Asn His Tyr Met Thr Leu Ser Leu Ser Tyr Tyr Ser Gln Thr
130 135 140Gln Gly Leu Arg Ser Arg Leu Lys Ile Leu Thr His Leu Ala Lys Leu145 150 155 160Leu Phe Arg Leu Gln Ser Lys Gly Leu Val Tyr Gly Asp Leu Asn Leu
165 170 175Asn Asn Val Phe Tyr Lys Asp Asn Ser Ala Phe Leu Ile Asp Ala Asp
180 185 190Asn Val Arg Tyr Glu Ser Glu Lys Ala Leu Cys Val Ile Phe Thr Pro
195 200 205Asn Tyr Gly Ala Leu Glu Ile Ser Gln Thr Ser Lys Asn Ser Asp Thr
210 215 220Thr Asn Tyr Asn Thr Met Leu Ser Asp Thr Phe Ser Phe Ala Ile Ile225 230 235 240Thr Tyr Glu Leu Leu Asn Met Val His Pro Phe Asp Gly Asn Lys Ala
245 250 255Asp Asp Ser Val Glu Asn Phe Ile Glu Leu Pro Trp Ile Glu Asp Arg
260 265 270Lys Asp Asp Ser Asn Arg Ser Cys Gly Leu Leu Pro Phe Phe Leu Thr
275 280 285Arg Asp Leu Lys Asn Leu Leu Ala
290295 (2) sequence 1311 materials: (i) sequence characteristics: length (A): 509bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 469 (D) other information: (xi) Description of the sequence: sequence 1311: ATGCTTTGAA GAAGGCAAAA AAGATCCTTT GAAACGCCCT ACT ATG CCC TTA TTT 55
Met Pro Leu Phe
1ATA GAG AGC TTA GAA AAA GCT AGC TTG CAA GTG TTA GAA TGT GAA AAT 103Ile Glu Ser Leu Glu Lys Ala Ser Leu Gln Val Leu Glu Cys Glu Asn5 10 15 20TGT TCA ATG ACT TAT TAT GAT AGA GAT TAT AAT AGA GAA TGT GAG ATT 151Cys Ser Met Thr Tyr Tyr Asp Arg Asp Tyr Asn Arg Glu Cys Glu Ile
2530 35TGC CCT TAT TGC GAT GCT AAA AAA CCT GTC AGA CTT GTA GCA ACA AGT 199Cys Pro Tyr Cys Asp Ala Lys Lys Pro Val Arg Leu Val Ala Thr Ser
40 45 50TAT TAC CAA AAG AGC GAA GTT TTT TAT TTT GTC TCG AAT TTT ACA GAC 247Tyr Tyr Gln Lys Ser Glu Val Phe Tyr Phe Val Ser Asn Phe Thr Asp
55 60 65CCT ATT TTT TTA CCG ACA ACC TTA TTT AAG GGG ATT GAA GTG GTT AAA 295Pro Ile Phe Leu Pro Thr Thr Leu Phe Lys Gly Ile Glu Val Val Lys
70 75 80AGC GAA TGG GAG TTT GCA GAG ATT GCT AAT AAT ATA TTG ATT TTT CAT 343Ser Glu Trp Glu Phe Ala Glu Ile Ala Asn Asn Ile Leu Ile Phe His85 90 95 100CAT GAC ATA CAA CAA GAA AAG ATT CTC ATT AAT AAT AAA AGA TTG GAT 391His Asp Ile Gln Gln Glu Lys Ile Leu Ile Asn Asn Lys Arg Leu Asp
105 110 115CAC TAT AGG ATA GAA ATA GAT TTA GAA AAA GAA TTG ACT ATT TCA TAC 439His Tyr Arg Ile Glu Ile Asp Leu Glu Lys Glu Leu Thr Ile Ser Tyr
120 125 130AAT GGT TTT TTA ATT AAG GTT CAA AAA TGC TGAGTTTTAT CAAAGAAGAT AGC 492Asn Gly Phe Leu Ile Lys Val Gln Lys Cys
135140 ATCATCAAGG CTTATAA 509 (2) sequence 1312 data: (i) sequence characteristics: length (A): 142 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1312: met Pro Leu Phe Ile Glu Ser Leu Glu Lys Ala Ser Leu Gln Val Leu 151015 Glu Cys Glu Asn Cys Ser Met Thr Tyr Tyr Asp Arg Asp Tyr Asn Arg
20 25 30Glu Cys Glu Ile Cys Pro Tyr Cys Asp Ala Lys Lys Pro Val Arg Leu
35 40 45Val Ala Thr Ser Tyr Tyr Gln Lys Ser Glu Val Phe Tyr Phe Val Ser
50 55 60Asn Phe Thr Asp Pro Ile Phe Leu Pro Thr Thr Leu Phe Lys Gly Ile65 70 75 80Glu Val Val Lys Ser Glu Trp Glu Phe Ala Glu Ile Ala Asn Asn Ile
85 90 95Leu Ile Phe His His Asp Ile Gln Gln Glu Lys Ile Leu Ile Asn Asn
100 105 110Lys Arg Leu Asp His Tyr Arg Ile Glu Ile Asp Leu Glu Lys Glu Leu
115 120 125Thr Ile Ser Tyr Asn Gly Phe Leu Ile Lys Val Gln Lys Cys
130135140 (2) sequence 1313 data: (i) sequence characteristics: length (A): 1260bp (b) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1193 (D) other information: (xi) Description of the sequence: sequence 1313: AATGGTTTTT TAATTAAGGT TCAAAA ATG CTG AGT TTT ATC AAA GAA GAT AGC 53
Met Leu Ser Phe Ile Lys Glu Asp Ser
1 5ATC ATC AAG GCT TAT AAC CTC AAT ACC GCA AAA CTA GAG CCA AAA GAT 101Ile Ile Lys Ala Tyr Asn Leu Asn Thr Ala Lys Leu Glu Pro Lys Asp10 15 20 25AGA GAA AAA TTG GGA TTA TTA AAG ATT GAA AAA AAT AAA ATA TAT TTT 149Arg Glu Lys Leu Gly Leu Leu Lys Ile Glu Lys Asn Lys Ile Tyr Phe
30 35 40CAT CTA GAT GAA AAG CGT TAT TTG AAA TTA GAG ATC ATA GGC AAA ACC 197His Leu Asp Glu Lys Arg Tyr Leu Lys Leu Glu Ile Ile Gly LysThr
45 50 55AAA GAA AAA GAA ATT AAA AAC GCT TTT TGC AGT AAT GCT TTT CTT GCA 245Lys Glu Lys Glu Ile Lys Asn Ala Phe Cys Ser Asn Ala Phe Leu Ala
60 65 70GCT CAA GTC CTA AAT TTA AAC CAA GAA AGA CAA GTT TTA GAA TTG AAG 293Ala Gln Val Leu Asn Leu Asn Gln Glu Arg Gln Val Leu Glu Leu Lys
75 80 85TGC CAT TTC TTC AAG CAC CCT ATA AAA ATT CTT CCT GAA CCA TTA AAC 341Cys His Phe Phe Lys His Pro Ile Lys Ile Leu Pro Glu Pro Leu Asn90 95 100 105ATT AAT TTC AAA GAC ACA ATC ATA AAA AAG TTA CTA AAA GAT ATG GGC 389Ile Asn Phe Lys Asp Thr Ile Ile Lys Lys Leu Leu Lys Asp Met Gly
110 115 120AAA GAT AAA AAA ATA GAA GAT TTT AAA GAA ACT TGT ATT TTA AAA ATA 437Lys Asp Lys Lys Ile Glu Asp Phe Lys Glu Thr Cys Ile Leu Lys Ile
125 130 135GCT GGT TTT ACT TAT TTT GTG TGC GTA TTG CCT TAT GAA TAT GAG AAT 485Ala Gly Phe Thr Tyr Phe Val Cys Val Leu Pro Tyr Glu Tyr Glu Asn
140 145 150AAA GAG GAT AAA GAG AAT AGT GAA GAG ATT TTA AAA GAA GAT TTC AGG 533Lys Glu Asp Lys Glu Asn Ser Glu Glu Ile Leu Lys Glu Asp Phe Arg
155 160 165CTG TTA AAT ACC AAG GGG GGA TTA AGC GTT AAG CGT GCT TTG ATA AAT 581Leu Leu Asn Thr Lys Gly Gly Leu Ser Val Lys Arg Ala Leu Ile Asn170 175 180 185AAC AGG CAT TCT TAT GAA GCG ATA AAA TTA AGA CCC ATT AAA CAA GAG 629Asn Arg His Ser Tyr Glu Ala Ile Lys Leu Arg Pro Ile Lys Gln Glu
190 195200TTA GTG CCT GGT TTG TGT TTG TTT TTT CAA GGT TCA TTA GAA TTT AAT 677Leu Val Pro Gly Leu Cys Leu Phe Phe Gln Gly Ser Leu Glu Phe Asn
205 210 215GAT AAA ACC ACA AAA ACC ATG CGA ACG AGC CTT TTA GAC CAG ATC CAG 725Asp Lys Thr Thr Lys Thr Met Arg Thr Ser Leu Leu Asp Gln Ile Gln
220 225 230CAA GAT GAC AAA TCT TAT TTA AAA ATT TGG GAA AAA TAT CTC ATC AAA 773Gln Asp Asp Lys Ser Tyr Leu Lys Ile Trp Glu Lys Tyr Leu Ile Lys
235 240 245AGC GCT CAA AAA AGT TTT AAT GAG GCA AAA GAA GTG GGG GTT TTA GAG 821Ser Ala Gln Lys Ser Phe Asn Glu Ala Lys Glu Val Gly Val Leu Glu250 255 260 265ATT GAA AGC GTG AGT AAA GAA GGA GGG AAT TTA AGA ATT CGT TTT AAG 869Ile Glu Ser Val Ser Lys Glu Gly Gly Asn Leu Arg Ile Arg Phe Lys
270 275 280CCA GCT TTA GGC AAG AAT AAA ATG GAA ATC TTA AAG AAA TCA CAA TTT 917Pro Ala Leu Gly Lys Asn Lys Met Glu Ile Leu Lys Lys Ser Gln Phe
285 290 295AAA AAG GGG AGT GAT TTA GGG GTT TTA GAG GAT TTA GAC CCA CAA AAT 965Lys Lys Gly Ser Asp Leu Gly Val Leu Glu Asp Leu Asp Pro Gln Asn
300 305 310GAA GAA AAT TTA ATC AAT CTT ATT TCT GAA CAA AAG AAA CAA ATT TCT 1013Glu Glu Asn Leu Ile Asn Leu Ile Ser Glu Gln Lys Lys Gln Ile Ser
315 320 325AAA AAC AAC AGC CAA TCA ATA ATG ATT GAA GAC ATT AGT GGG GAT GAT 1061Lys Asn Asn Ser Gln Ser Ile Met Ile Glu Asp Ile Ser Gly Asp Asp330 335 340 345TTT ATT ATA GAT TAC GAT CTT TCC ATA AAA GAG GGC GAT GCT TTT CAT 1109Phe Ile Ile Asp Tyr Asp Leu Ser IleLys Glu Gly Asp Ala Phe His
350 355 360TTA AAT TAT ATG GGG GAT CTA AAT ACG CTT AAA AAA CAA TAT AGC GCA 1157Leu Asn Tyr Met Gly Asp Leu Asn Thr Leu Lys Lys Gln Tyr Ser Ala
365 370 375TTA GAT AAG ACA AAG AAA GGT TTG AAG CGC CAA TCC TAATTTAGGA TTAATT 1209Leu Asp Lys Thr Lys Lys Gly Leu Lys Arg Gln Ser
380385 TTAAACATTA AAGAGGATAA AGAGAATAGT GATAGCGATA ATGATACTGC A1260 (1260) (2) sequence 1314 data: (i) sequence characteristics: length (A): 389 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1314: met Leu Ser Phe Ile Lys Glu Asp Ser Ile Ile Lys Ala Tyr Asn Leu 151015 Asn Thr Ala Lys Leu Glu Pro Lys Asp Arg Glu Lys Leu Gly Leu Leu
20 25 30Lys Ile Glu Lys Asn Lys Ile Tyr Phe His Leu Asp Glu Lys Arg Tyr
35 40 45Leu Lys Leu Glu Ile Ile Gly Lys Thr Lys Glu Lys Glu Ile Lys Asn
50 55 60Ala Phe Cys Ser Asn Ala Phe Leu Ala Ala Gln Val Leu Asn Leu Asn65 70 75 80Gln Glu Arg Gln Val Leu Glu Leu Lys Cys His Phe Phe Lys His Pro
85 90 95Ile Lys Ile Leu Pro Glu Pro Leu Asn Ile Asn Phe Lys Asp Thr Ile
100 105 110Ile Lys Lys Leu Leu Lys Asp Met Gly Lys Asp Lys Lys Ile Glu Asp
115 120 125Phe Lys Glu Thr Cys Ile Leu Lys Ile Ala Gly Phe Thr Tyr Phe Val
130 135140Cys Val Leu Pro Tyr Glu Tyr Glu Asn Lys Glu Asp Lys Glu Asn Ser145 150 155 160Glu Glu Ile Leu Lys Glu Asp Phe Arg Leu Leu Asn Thr Lys Gly Gly
165 170 175Leu Ser Val Lys Arg Ala Leu Ile Asn Asn Arg His Ser Tyr Glu Ala
180 185 190Ile Lys Leu Arg Pro Ile Lys Gln Glu Leu Val Pro Gly Leu Cys Leu
195 200 205Phe Phe Gln Gly Ser Leu Glu Phe Asn Asp Lys Thr Thr Lys Thr Met
210 215 220Arg Thr Ser Leu Leu Asp Gln Ile Gln Gln Asp Asp Lys Ser Tyr Leu225 230 235 240Lys Ile Trp Glu Lys Tyr Leu Ile Lys Ser Ala Gln Lys Ser Phe Asn
245 250 255Glu Ala Lys Glu Val Gly Val Leu Glu Ile Glu Ser Val Ser Lys Glu
260 265 270Gly Gly Asn Leu Arg Ile Arg Phe Lys Pro Ala Leu Gly Lys Asn Lys
275 280 285Met Glu Ile Leu Lys Lys Ser Gln Phe Lys Lys Gly Ser Asp Leu Gly
290 295 300Val Leu Glu Asp Leu Asp Pro Gln Asn Glu Glu Asn Leu Ile Asn Leu305 310 315 320Ile Ser Glu Gln Lys Lys Gln Ile Ser Lys Asn Asn Ser Gln Ser Ile
325 330 335Met Ile Glu Asp Ile Ser Gly Asp Asp Phe Ile Ile Asp Tyr Asp Leu
340 345 350Ser Ile Lys Glu Gly Asp Ala Phe His Leu Asn Tyr Met Gly Asp Leu
355360 365Asn Thr Leu Lys Lys Gln Tyr Ser Ala Leu Asp Lys Thr Lys Lys Gly
370375380 Leu Lys Arg Gln Ser385 (2) sequence 1315 data: (i) sequence characteristics: length (A): 1185bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1113 (D) other information: (xi) Description of the sequence: sequence 1315: TCCATAGGCT AGTTG ATG TCA AAA AGA AGC GAA GTT TTA GAA CAA TTT CAT 51
Met Ser Lys Arg Ser Glu Val Leu Glu Gln Phe His
1 5 10GGC GGT TTA AAA AAT TTA GAA TTA CAA ACT AAA AGA CGC ATG GGT TTG 99Gly Gly Leu Lys Asn Leu Glu Leu Gln Thr Lys Arg Arg Met Gly Leu
15 20 25TGG GGC GAT CCA AAA GAG AAT GAA GAA CAA ACT TTG TTT TTA GAA GAA 147Trp Gly Asp Pro Lys Glu Asn Glu Glu Gln Thr Leu Phe Leu Glu Glu
30 35 40ATT GAA AAT GAA TTA AAG CAA TTA GAA AAC AAA GAA AAT CTT AAA GCA 195Ile Glu Asn Glu Leu Lys Gln Leu Glu Asn Lys Glu Asn Leu Lys Ala45 50 55 60GAC AAC AAC ACA GAA TTT AAA GAA GAA AAT CAA GAC ACT AAA GAA AAC 243Asp Asn Asn Thr Glu Phe Lys Glu Glu Asn Gln Asp Thr Lys Glu Asn
65 70 75CAG CCT AAC GAT TTG TTT TCT TTG CCA TTG CCC ACT CAA ACC ACC ATC 291Gln Pro Asn Asp Leu Phe Ser Leu Pro Leu Pro Thr Gln Thr Thr Ile
80 85 90AAT GGA ATT AAA GAA TTT GTA GAA GAG CCT GTG ATA GAA ACA GAG AAA 339Asn Gly Ile Lys Glu Phe Val Glu Glu Pro Val Ile Glu Thr Glu Lys
95 100105AAA GAA ACA TCC CAA AAT GAG CCA ATC CAA GAA AAA AAA GAA AGA ATT 387Lys Glu Thr Ser Gln Asn Glu Pro Ile Gln Glu Lys Lys Glu Arg Ile
110 115 120TTT AAA AAC TTT TTC TCC AGA ATA GGC TTT GAT AAA AGT ATT GCC CCT 435Phe Lys Asn Phe Phe Ser Arg Ile Gly Phe Asp Lys Ser Ile Ala Pro125 130 135 140ACA ATG CTT TTT GAA GAA GTG AGA GAT GCA AGC GTT ATC TAT CAT TTA 483Thr Met Leu Phe Glu Glu Val Arg Asp Ala Ser Val Ile Tyr His Leu
145 150 155GAG AAA AAA TTA GGC GAT TAT ATC TTT TAT GTA GCG TGT TTC TTC TTT 531Glu Lys Lys Leu Gly Asp Tyr Ile Phe Tyr Val Ala Cys Phe Phe Phe
160 165 170GGC ACA ACG GCA TTG CTT ATT ATC TTA CTG ACT ATT CTG TTG CCC TTA 579Gly Thr Thr Ala Leu Leu Ile Ile Leu Leu Thr Ile Leu Leu Pro Leu
175 180 185AAA CAA AAA GAG CCG TAT TTA GTG CAA TTT TCT AAC AAT AAA GAA AAT 627Lys Gln Lys Glu Pro Tyr Leu Val Gln Phe Ser Asn Asn Lys Glu Asn
190 195 200TTT GCT TTA GTT CAA AAG GCA GAT AGC AGC ATT ACA GCC AAT AAA GCT 675Phe Ala Leu Val Gln Lys Ala Asp Ser Ser Ile Thr Ala Asn Lys Ala205 210 215 220CTT ATT CGT TCA TTA GTG GGA GCG TAT GTG CTA AAC AGG GAA AGC ATT 723Leu Ile Arg Ser Leu Val Gly Ala Tyr Val Leu Asn Arg Glu Ser Ile
225 230 235ACT CAT ATT GAG CAA CAT GAA AAA ATG CGT CAA AAC ACC ATT AAA GAG 771Thr His Ile Glu Gln His Glu Lys Met Arg Gln Asn Thr Ile Lys Glu
240 245 250CAA AGT TCC AAT GAA GTA TGG TAT GAA TTT GAA AAA CTC ATC GCT CAT819Gln Ser Ser Asn Glu Val Trp Tyr Glu Phe Glu Lys Leu Ile Ala His
255 260 265TAT GAC AGC ATT TAC ACT AAT CCT TTA CTC ACA AGA AAA GTA AAG ATT 867Tyr Asp Ser Ile Tyr Thr Asn Pro Leu Leu Thr Arg Lys Val Lys Ile
270 275 280GCA AAT ATT TAC TTA GAT AAA GAT TTA GCC TAT ATT GAC ATT GAA GTG 915Ala Asn Ile Tyr Leu Asp Lys Asp Leu Ala Tyr Ile Asp Ile Glu Val285 290 295 300AGC TTG TAT CAT AGT GGA GAA TTA GAG AGC TTG AAG CGC TAT AAA GTG 963Ser Leu Tyr His Ser Gly Glu Leu Glu Ser Leu Lys Arg Tyr Lys Val
305 310 315GTG ATG AGT TTT GAA TTT AAA AAA CAA GAA ATC AAT TTT GAC TCC ATG 1011Val Met Ser Phe Glu Phe Lys Lys Gln Glu Ile Asn Phe Asp Ser Met
320 325 330TCT TTA AAT CCT ACA GGC TTT ATG GTT ACA AGT TAT GAT GTA ACT GAA 1059Ser Leu Asn Pro Thr Gly Phe Met Val Thr Ser Tyr Asp Val Thr Glu
335 340 345ATT GCG ATT GTG AAT TAC CCA ACC GCT AAA GCG ATT GGG CTT TTT CTT 1107Ile Ala Ile Val Asn Tyr Pro Thr Ala Lys Ala Ile Gly Leu Phe Leu
350355360 GCT TCA TAGCTCCATA ACTAGCTAGA TCCAATATGT TTCCATATTT AGAACTAACC CC 1165Ala Ser365GTTAGAGGAA GCTCCACAAG 1185 (2) sequence 1316 data: (i) sequence characteristics: length (A): 366 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1316: met Ser Lys Arg Ser Glu Val Leu Glu Gln Phe His Gly Gly Leu Lys 151015 Asn Leu Glu Leu Gln Thr Lys Arg Arg Met Gly Leu Trp Gly Asp Pro
20 25 30Lys Glu Asn Glu Glu Gln Thr Leu Phe Leu Glu Glu Ile Glu AsnGlu
35 40 45Leu Lys Gln Leu Glu Asn Lys Glu Asn Leu Lys Ala Asp Asn Asn Thr
50 55 60Glu Phe Lys Glu Glu Asn Gln Asp Thr Lys Glu Asn Gln Pro Asn Asp65 70 75 80Leu Phe Ser Leu Pro Leu Pro Thr Gln Thr Thr Ile Asn Gly Ile Lys
85 90 95Glu Phe Val Glu Glu Pro Val Ile Glu Thr Glu Lys Lys Glu Thr Ser
100 105 110Gln Asn Glu Pro Ile Gln Glu Lys Lys Glu Arg Ile Phe Lys Asn Phe
115 120 125Phe Ser Arg Ile Gly Phe Asp Lys Ser Ile Ala Pro Thr Met Leu Phe
130 135 140Glu Glu Val Arg Asp Ala Ser Val Ile Tyr His Leu Glu Lys Lys Leu145 150 155 160Gly Asp Tyr Ile Phe Tyr Val Ala Cys Phe Phe Phe Gly Thr Thr Ala
165 170 175Leu Leu Ile Ile Leu Leu Thr Ile Leu Leu Pro Leu Lys Gln Lys Glu
180 185 190Pro Tyr Leu Val Gln Phe Ser Asn Asn Lys Glu Asn Phe Ala Leu Val
195 200 205Gln Lys Ala Asp Ser Ser Ile Thr Ala Asn Lys Ala Leu Ile Arg Ser
210 215 220Leu Val Gly Ala Tyr Val Leu Asn Arg Glu Ser Ile Thr His Ile Glu225 230 235 240Gln His Glu Lys Met Arg Gln Asn Thr Ile Lys Glu Gln Ser Ser Asn
245 250 255Glu Val Trp Tyr Glu Phe Glu Lys Leu Ile Ala His Tyr Asp SerIle
260 265 270Tyr Thr Asn Pro Leu Leu Thr Arg Lys Val Lys Ile Ala Asn Ile Tyr
275 280 285Leu Asp Lys Asp Leu Ala Tyr Ile Asp Ile Glu Val Ser Leu Tyr His
290 295 300Ser Gly Glu Leu Glu Ser Leu Lys Arg Tyr Lys Val Val Met Ser Phe305 310 315 320Glu Phe Lys Lys Gln Glu Ile Asn Phe Asp Ser Met Ser Leu Asn Pro
325 330 335Thr Gly Phe Met Val Thr Ser Tyr Asp Val Thr Glu Ile Ala Ile Val
340 345 350Asn Tyr Pro Thr Ala Lys Ala Ile Gly Leu Phe Leu Ala Ser
355360365 (2) sequence 1317 data: (i) sequence characteristics: length (A): 745bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 717 (D) other information: (xi) Description of the sequence: sequence 1317: TAAGGGGGGA TTTGGAAGGT GTTGGAATTG AAATTA ATG GGA CAG AAG AGG ATG 54
Met Gly Gln Lys Arg Met
1 5AAT AAA TCA AAC AAA TTA GTC ATT ATC AAT CGC GCC ATT CCA GGT GGG 102Asn Lys Ser Asn Lys Leu Val Ile Ile Asn Arg Ala Ile Pro Gly Gly
10 15 20GGC AAG ACC TCT TTG ATC AAA CAG ATT GAA GAG TTG GCA AAA AGC TTG 150Gly Lys Thr Ser Leu Ile Lys Gln Ile Glu Glu Leu Ala Lys Ser Leu
25 30 35GGG CAT TCT ATT AGC GTT CAT TCT ACC GAT GAA TAT TTC ATC CAA ACA 198Gly His Ser Ile Ser Val His Ser Thr Asp Glu Tyr Phe Ile Gln Thr
40 45 50GAT GAA GAG GGT ATC AGG CAT TAT GTT GTT GAT AAA AAG AAA CTC AAT 246Asp Glu Glu Gly Ile Arg His Tyr Val Val Asp Lys Lys Lys Leu Asn55 60 65 70GAA TAC CAC CAA AAC AAT CAA GAA GCC TTC AAA CAA GCT TTA GAA AAT 294Glu Tyr His Gln Asn Asn Gln Glu Ala Phe Lys Gln Ala Leu Glu Asn
75 80 85CGT ATA GAT ATT GTA GTG TGC GAT AAC ACC AAT TTT GAA TCG TGG CAA 342Arg Ile Asp Ile Val Val Cys Asp Asn Thr Asn Phe Glu Ser Trp Gln
90 95 100AGC AAA CCA TAT ACA GAT ATG GCT AGA GAA TTT GGC TAT AAA ATT TTG 390Ser Lys Pro Tyr Thr Asp Met Ala Arg Glu Phe Gly Tyr Lys Ile Leu
105 110 115TTG ATT GAT TTT AAG AAT AGA CAC TTA GAA ACC CCC ATG GAT TAT GGA 438Leu Ile Asp Phe Lys Asn Arg His Leu Glu Thr Pro Met Asp Tyr Gly
120 125 130TGG GAT GTT GCG CAA TGC ATC AAG AAG CCA CGA GGT ATT GCA AAG CAT 486Trp Asp Val Ala Gln Cys Ile Lys Lys Pro Arg Gly Ile Ala Lys His135 140 145 150TAT GAC TAT GAT TTT TAT TTG GAG AGG GTT TTG GTT GAG CCA CAG GAT 534Tyr Asp Tyr Asp Phe Tyr Leu Glu Arg Val Leu Val Glu Pro Gln Asp
155 160 165TAT GAG AAA CAA AAT AGA GAG TTG AGC TTA AAA GCC TTA GAA TTT TTG 582Tyr Glu Lys Gln Asn Arg Glu Leu Ser Leu Lys Ala Leu Glu Phe Leu
170 175 180AAA TAC AAT TTT GAT TTT GAT GTG ATT TTT TAT TCT TTT GGG GAG CAA 630Lys Tyr Asn Phe Asp Phe Asp Val Ile Phe Tyr Ser Phe Gly Glu Gln
185 190 195TTA ATG CCT ATT CTT ACT AGA ATG TTA GTT TCT GTC TCT AAG TCT CAT 678Leu Met Pro Ile Leu Thr Arg Met Leu Val Ser Val Ser Lys Ser His
200205210 AGA AAG AGA CTT GAA AAC TAT GGC AAA GAC ATT AAA ACC TAATTTAGAT AA 729Arg Lys Arg Leu Glu Asn Tyr Gly Lys Asp Ile Lys Thr 215220225 AGATGAGTTA AACACA 745 (2) sequence 1318 data: (i) sequence characteristics: length (A): 227 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1318: met Gly Gln Lys Arg Met Asn Lys Ser Asn Lys Leu Val Ile Ile Asn 151015 Arg Ala Ile Pro Gly Gly Gly Lys Thr Ser Leu Ile Lys Gln Ile Glu
20 25 30Glu Leu Ala Lys Ser Leu Gly His Ser Ile Ser Val His Ser Thr Asp
35 40 45Glu Tyr Phe Ile Gln Thr Asp Glu Glu Gly Ile Arg His Tyr Val Val
50 55 60Asp Lys Lys Lys Leu Asn Glu Tyr His Gln Asn Asn Gln Glu Ala Phe65 70 75 80Lys Gln Ala Leu Glu Asn Arg Ile Asp Ile Val Val Cys Asp Asn Thr
85 90 95Asn Phe Glu Ser Trp Gln Ser Lys Pro Tyr Thr Asp Met Ala Arg Glu
100 105 110Phe Gly Tyr Lys Ile Leu Leu Ile Asp Phe Lys Asn Arg His Leu Glu
115 120 125Thr Pro Met Asp Tyr Gly Trp Asp Val Ala Gln Cys Ile Lys Lys Pro
130 135 140Arg Gly Ile Ala Lys His Tyr Asp Tyr Asp Phe Tyr Leu Glu Arg Val145 150 155 160Leu Val Glu Pro Gln Asp Tyr Glu Lys Gln Asn Arg Glu Leu Ser Leu
165 170 175Lys Ala Leu Glu Phe Leu Lys Tyr Asn Phe Asp Phe Asp Val Ile Phe
180 185 190Tyr Ser Phe Gly Glu Gln Leu Met Pro Ile Leu Thr Arg Met Leu Val
195 200 205Ser Val Ser Lys Ser His Arg Lys Arg Leu Glu Asn Tyr Gly Lys Asp
210215220 Ile Lys Thr225 (2) sequence 1319 data: (i) sequence characteristics: length (A): 531bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 468 (D) other information: (xi) Description of the sequence: sequence 1319: ATTTACTAAA GGAAAACA ATG ATT AAA CTA ATC TTA CAC AAG AAG TCC ATA 51
Met Ile Lys Leu Ile Leu His Lys Lys Ser Ile
1 5 10CAA ATT GAT GAA ACA TTG CTG AAT GTA AAA GAG CAT TTA GAA AAG TTT 99Gln Ile Asp Glu Thr Leu Leu Asn Val Lys Glu His Leu Glu Lys Phe
15 20 25TAT TCA AAT AAA GAA CAA GAG ACA ATC GCT CAA ACT TTA GAG AAT GAA 147Tyr Ser Asn Lys Glu Gln Glu Thr Ile Ala Gln Thr Leu Glu Asn Glu
30 35 40ACA GAA ATT TCT TGT AGC TAT TTT TGG GAC AAA GAC TTC TTG TTG TTA 195Thr Glu Ile Ser Cys Ser Tyr Phe Trp Asp Lys Asp Phe Leu Leu Leu
45 50 55GAG CAA CTT TTA GAA AAT RAT TTA GGT CAT TTT ACC TTT GAG AGC GAG 243Glu Gln Leu Leu Glu Asn Xaa Leu Gly His Phe Thr Phe Glu Ser Glu60 65 70 75TTT GCC CTA CTA AAA GAT AAA GAG ACT TTA AAC CTA TCT CAA ATC AAA 291Phe Ala Leu Leu Lys Asp Lys Glu Thr Leu Asn Leu Ser Gln Ile Lys
80 85 90CAA ATC GGT GTC TTA AAG GTT CTT ACC TAT GAR ATG ATA CAA ACC TTA 339Gln Ile Gly Val Leu Lys Val Leu Thr Tyr Xaa Met Ile Gln Thr Leu
95 100 105AAA AAT CAA ATC ATT CAT TTA GCA CAA GTT GTC AAT GAA GAA AAT TTA 387Lys Asn Gln Ile Ile His Leu Ala Gln Val Val Asn Glu Glu Asn Leu
110 115 120GAA AAA GAT GAA GAA CTT GTT GTC TAC CAC CTA AAT TTC ACG TCA CGC 435Glu Lys Asp Glu Glu Leu Val Val Tyr His Leu Asn Phe Thr Ser Arg
125130135 AAC AAT CTT ACA AAA TAT TAT CCA AGT TCT GTG TGATTAAAAA AGAAAGAAAT 488Asn Asn Leu Thr Lys Tyr Tyr Pro Ser Ser Val 140145150 ATCGATGAA AAAATTAAGT CATTTTAGAA AGCTTATCGC CTT 531 (2) sequence 1320 data: (i) sequence characteristics: length (A): 150 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1320: met Ile Lys Leu Ile Leu His Lys Lys Ser Ile Gln Ile Asp Glu Thr 151015 Leu Leu Asn Val Lys Glu His Leu Glu Lys Phe Tyr Ser Asn Lys Glu
20 25 30Gln Glu Thr Ile Ala Gln Thr Leu Glu Asn Glu Thr Glu Ile Ser Cys
35 40 45Ser Tyr Phe Trp Asp Lys Asp Phe Leu Leu Leu Glu Gln Leu Leu Glu
50 55 60Asn Xaa Leu Gly His Phe Thr Phe Glu Ser Glu Phe Ala Leu Leu Lys65 70 75 80Asp Lys Glu Thr Leu Asn Leu Ser Gln Ile Lys Gln Ile Gly Val Leu
85 90 95Lys Val Leu Thr Tyr Xaa Met Ile Gln Thr Leu Lys Asn Gln Ile Ile
100 105 110His Leu Ala Gln Val Val Asn Glu Glu Asn Leu Glu Lys Asp Glu Glu
115 120 125Leu Val Val Tyr His Leu Asn Phe Thr Ser Arg Asn Asn Leu Thr Lys
130135140 Tyr Tyr Pro Ser Ser Val 145150 (2) sequence 1321 data: (i) sequence characteristics: length (A): 334bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 294 (D) other information: (xi) Description of the sequence: sequence 1321: CTGGTTTATG AGTATTTTTT AAAAGAAGTC CCC ATG CAA TTA GTT GGT ATT TCA 54
Met Gln Leu Val Gly Ile Ser
1 5GTT TCT AAT CTC AAA GAA ATC AGC TCC AAA GAA AAA TTT CTT TGG CTC 102Val Ser Asn Leu Lys Glu Ile Ser Ser Lys Glu Lys Phe Leu Trp Leu
l0 15 20AAT GCT AAG AGT TTT TTA CTC TCA GGA TTT GTG CCT TTT ATT ATG ATA 150Asn Ala Lys Ser Phe Leu Leu Ser Gly Phe Val Pro Phe Ile Met Ile
25 30 35CCT TGG CTA GAT ATA TTG AAC TCT TTT GTG CTT TAT GTG TGC TTT CTC 198Pro Trp Leu Asp Ile Leu Asn Ser Phe Val Leu Tyr Val Cys Phe Leu40 45 50 55TTA ATT TTT AGC ATA GCG GAG TTC TTT GAT GAA GAT ATA AGT GAC ATT 246Leu Ile Phe Ser Ile Ala Glu Phe Phe Asp Glu Asp Ile Ser Asp Ile
60 65 70TTA ATC GCT CAT TCC AAA ATT AAA ACC AAA GCT AAT TCA TTT TAC GCT T 295Leu Ile Ala His Ser Lys Ile Lys Thr Lys Ala Asn Ser Phe Tyr Ala
758085 AAAAGGAAAA AATATGCAAA AAGAAGTCTT AGTAGAAAA 334 (2) sequence 1322 data: (i) sequence characteristics: length (A): 87 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1322: met Gln Leu Val Gly Ile Ser Val Ser Asn Leu Lys Glu Ile Ser Ser 151015 Lys Glu Lys Phe Leu Trp Leu Asn Ala Lys Ser Phe Leu Leu Ser Gly
20 25 30Phe Val Pro Phe Ile Met Ile Pro Trp Leu Asp Ile Leu Asn Ser Phe
35 40 45Val Leu Tyr Val Cys Phe Leu Leu Ile Phe Ser Ile Ala Glu Phe Phe
50 55 60Asp Glu Asp Ile Ser Asp Ile Leu Ile Ala His Ser Lys Ile Lys Thr65 70 75 80Lys Ala Asn Ser Phe Tyr Ala
85 (2) sequence 1323 data: (i) sequence characteristics: length (A): 995bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 948 (D) other information: (xi) Description of the sequence: sequence 1323: TAAAAACACC CCTAAAAGAA AAAGAAAGTC TTCTTA ATG TTA GAA AGC GCC CTT 54
Met Leu Glu Ser Ala Leu
1 5AAA TAT TGC AAG GAA AAA GCC ATA GAC CTT TTA GTA GGG TTT GTG CCA 102Lys Tyr Cys Lys Glu Lys Ala Ile Asp Leu Leu Val Gly Phe Val Pro
10 15 20AAA ACC TAT TCT ATG GCA CAA GAG TGC AAT ATT TTA GGC TTG TAT GAT 150Lys Thr Tyr Ser Met Ala Gln Glu Cys Asn Ile Leu Gly Leu Tyr Asp
25 30 35GAT GCT TTC ATT ATT ACC AAA CAAGAA AAT CTA GTA GGC ATT ATA TCC 198Asp Ala Phe Ile Ile Thr Lys Gln Glu Asn Leu Val Gly Ile Ile Ser
40 45 50TTA CAA GGA CTA AGC TAT TCT AAT TTA ATG CAA AAA GAC TTA GAG GGC 246Leu Gln Gly Leu Ser Tyr Ser Asn Leu Met Gln Lys Asp Leu Glu Gly55 60 65 70TAT TTT GAT GCT AGA CAA AAT GTT CTC AAC ACC ATT AGT AAA GAC ATT 294Tyr Phe Asp Ala Arg Gln Asn Val Leu Asn Thr Ile Ser Lys Asp Ile
75 80 85CAA TTA AGA ATT GTG GCT AAA AGG CGT AAG GAA TTT ATC AAT CAA AGT 342Gln Leu Arg Ile Val Ala Lys Arg Arg Lys Glu Phe Ile Asn Gln Ser
90 95 100CCA AAT ATT GAC AAT ATT TAT GCC AAA GCT ATT ATC ACA CAA TTT GAA 390Pro Asn Ile Asp Asn Ile Tyr Ala Lys Ala Ile Ile Thr Gln Phe Glu
105 110 115AGC AAG GGA ATC TAT AAA ACA GAG TAT TTT TTA GTG TTT GAA ACT ATC 438Ser Lys Gly Ile Tyr Lys Thr Glu Tyr Phe Leu Val Phe Glu Thr Ile
120 125 130ACT TCT AAT GTC AAG TCT TTC TTT GAA AAA AAG AAA TTG GAA ATG ACT 486Thr Ser Asn Val Lys Ser Phe Phe Glu Lys Lys Lys Leu Glu Met Thr135 140 145 150ACT TCA ATT AAT GAA GAG TTA GAA GAA AGC TCT AAA GAA GAT AAA CAA 534Thr Ser Ile Asn Glu Glu Leu Glu Glu Ser Ser Lys Glu Asp Lys Gln
155 160 165GAG AAT GAA AAT MGC TCC AAT GAA ACT CAT TCA AAC ACA AGC TCT AAA 582Glu Asn Glu Asn Xaa Ser Asn Glu Thr His Ser Asn Thr Ser Ser Lys
170 175 180AAA GAC AAG AAA AAC AAG TTC AAA AAA AAG ATA ACC TTT AGC ACC AAA 630Lys Asp Lys Lys Asn Lys Phe Lys Lys Lys Ile Thr Phe Ser Thr Lys
185 190 195AGT AAA AGA GCC TTA CTC ATT CAA ACC ATA GAA AGA GTA AAA AAC GCT 678Ser Lys Arg Ala Leu Leu Ile Gln Thr Ile Glu Arg Val Lys Asn Ala
200 205 210CTT AAA GAA TTT AAA CCC ACT TTA CTA AAT TCT AAA GAA GTA TTA AAT 726Leu Lys Glu Phe Lys Pro Thr Leu Leu Asn Ser Lys Glu Val Leu Asn215 220 225 230TTC TAC GCA GAA TAC ATC AAT GGC AAA TAC ATC GCC TTT AAT CCT AAA 774Phe Tyr Ala Glu Tyr Ile Asn Gly Lys Tyr Ile Ala Phe Asn Pro Lys
235 240 245TTA AAG CGA TTA AGC GAT ACT ATA TTG CAT CTA ATG TGC ATT TTA AGA 822Leu Lys Arg Leu Ser Asp Thr Ile Leu His Leu Met Cys Ile Leu Arg
250 255 260AAG ATT ACT TTG TCA TTG AAT TTC AAA ATC AAA ACA CCT TTT GTG CGT 870Lys Ile Thr Leu Ser Leu Asn Phe Lys Ile Lys Thr Pro Phe Val Arg
265 270 275GTG TGG GGA TTA AGG CTT ATG AGA GCG AAG AAA TTT CTT CGC TCC CTA 918Val Trp Gly Leu Arg Leu Met Arg Ala Lys Lys Phe Leu Arg Ser Leu
280285290 TAT CTA CTC TTT TAC ACA CCC AAA TTG AAC TAGATTTAAT CTTTCATATC CGC 971Tyr Leu Leu Phe Tyr Thr Pro Lys Leu Asn 295300 TCTTTAGGGC AATTTGAAAG CCTG 995 (2) sequence 1324 data: (i) sequence characteristics: length (A): 304 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1324: met Leu Glu Ser Ala Leu Lys Tyr Cys Lys Glu Lys Ala Ile Asp Leu 151015 Leu Val Gly Phe Val Pro Lys Thr Tyr Ser Met Ala Gln Glu Cys Asn
20 25 30Ile Leu Gly Leu Tyr Asp Asp Ala Phe Ile Ile Thr Lys Gln Glu Asn
35 40 45Leu Val Gly Ile Ile Ser Leu Gln Gly Leu Ser Tyr Ser Asn Leu Met
50 55 60Gln Lys Asp Leu Glu Gly Tyr Phe Asp Ala Arg Gln Asn Val Leu Asn65 70 75 80Thr Ile Ser Lys Asp Ile Gln Leu Arg Ile Val Ala Lys Arg Arg Lys
85 90 95Glu Phe Ile Asn Gln Ser Pro Asn Ile Asp Asn Ile Tyr Ala Lys Ala
100 105 110Ile Ile Thr Gln Phe Glu Ser Lys Gly Ile Tyr Lys Thr Glu Tyr Phe
115 120 125Leu Val Phe Glu Thr Ile Thr Ser Asn Val Lys Ser Phe Phe Glu Lys
130 135 140Lys Lys Leu Glu Met Thr Thr Ser Ile Asn Glu Glu Leu Glu Glu Ser145 150 155 160Ser Lys Glu Asp Lys Gln Glu Asn Glu Asn Xaa Ser Asn Glu Thr His
165 170 175Ser Asn Thr Ser Ser Lys Lys Asp Lys Lys Asn Lys Phe Lys Lys Lys
180 185 190Ile Thr Phe Ser Thr Lys Ser Lys Arg Ala Leu Leu Ile Gln Thr Ile
195 200 205Glu Arg Val Lys Asn Ala Leu Lys Glu Phe Lys Pro Thr Leu Leu Asn
210 215 220Ser Lys Glu Val Leu Asn Phe Tyr Ala Glu Tyr Ile Asn Gly Lys Tyr225 230 235 240Ile Ala Phe Asn Pro Lys Leu Lys Arg Leu Ser Asp Thr Ile Leu His
245 250 255Leu Met Cys Ile Leu Arg Lys Ile Thr Leu Ser Leu Asn Phe Lys Ile
260 265 270Lys Thr Pro Phe Val Arg Val Trp Gly Leu Arg Leu Met Arg Ala Lys
275 280 285Lys Phe Leu Arg Ser Leu Tyr Leu Leu Phe Tyr Thr Pro Lys Leu Asn
290295300 (2) sequence 1325 data: (i) sequence characteristics: length (A): 1598bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1556 (D) other information: (xi) Description of the sequence: sequence 1325: ATAATTATAT AGAATTAGTG CAAGCCAATC GTTTGAGC ATG CAA GAG TGT GCT TTA 56
Met Gln Glu Cys Ala Leu
1 5AAC TTA GTT ATA AGG GCT AAA AGT AAA GCT AAA TTA GAC AAG TCT TTA 104Asn Leu Val Ile Arg Ala Lys Ser Lys Ala Lys Leu Asp Lys Ser Leu
10 15 20AAA GAG ATT TTA TCC TTG CTT AAT AAT GCT GGA CTA GGC AGT GTT ACA 152Lys Glu Ile Leu Ser Leu Leu Asn Asn Ala Gly Leu Gly Ser Val Thr
25 30 35GAA ACT ATA GGG CTA AAA CCA TCT TAT TTT TCA TTC TTC CCA AAT AAC 200Glu Thr Ile Gly Leu Lys Pro Ser Tyr Phe Ser Phe Phe Pro Asn Asn
40 45 50GCC AAT ATC AAC CCT AGA ATG AGA CAT CAA ACT TCC CAA GTC ATA GCA 248Ala Asn Ile Asn Pro Arg Met Arg His Gln Thr Ser Gln Val Ile Ala55 60 65 70TCT TTG ATT TTG TTT GAG AAA AAT AAT ACA GGT TTT AGA GCA AAT TCT 296Ser Leu Ile Leu Phe Glu Lys Asn Asn Thr Gly Phe Arg Ala Asn Ser
75 80 85TGG GGG GATATG CCC TTA TCT GTG TTT AAG AAC CTA GAC CAT AGC CCT 344Trp Gly Asp Met Pro Leu Ser Val Phe Lys Asn Leu Asp His Ser Pro
90 95 100TAT TTG TTT AAT TTT CAT AAT CAA GAA GTC AAA CAT AAG GGC GTG TTA 392Tyr Leu Phe Asn Phe His Asn Gln Glu Val Lys His Lys Gly Val Leu
105 110 115GCC CAC AAT GTC GCA CGA GTA GTG GGA CAT ACC ATG ATT ATA GGA GCA 440Ala His Asn Val Ala Arg Val Val Gly His Thr Met Ile Ile Gly Ala
120 125 130ACA GGT GCT GGT AAA ACC ACA CTC ATT AGC TAT TTG ATG ATG AGT GCC 488Thr Gly Ala Gly Lys Thr Thr Leu Ile Ser Tyr Leu Met Met Ser Ala135 140 145 150TTA AAA TAT TCT AAC ATT GAT ATT TTA GCT CTT GAT AGA CTA AAT GGT 536Leu Lys Tyr Ser Asn Ile Asp Ile Leu Ala Leu Asp Arg Leu Asn Gly
155 160 165TTG TAT TCC TTT ACC AAG TAT TTT GAT GGG ATT TAT AAT CAA GGC GAA 584Leu Tyr Ser Phe Thr Lys Tyr Phe Asp Gly Ile Tyr Asn Gln Gly Glu
170 175 180AAC TTT CAT ATT AAC CCT TTT TCA TTA GAA GAT AGC GCA ACT AAT AGA 632Asn Phe His Ile Asn Pro Phe Ser Leu Glu Asp Ser Ala Thr Asn Arg
185 190 195GCC TTT TTA TTG CAT TTT TAT GCC CAA ATG GCA AAA GTG GAT AGT TAT 680Ala Phe Leu Leu His Phe Tyr Ala Gln Met Ala Lys Val Asp Ser Tyr
200 205 210GAT GAC CAT AAG GAT AAA GTA GAA GAT AGA ACA GCC CTT TTA AAT GCT 728Asp Asp His Lys Asp Lys Val Glu Asp Arg Thr Ala Leu Leu Asn Ala215 220 225 230ATT GAT ACG ATG TAT AGA AAT TAT AAC GAT GAA GTC AAA CAA GCC AAA 776Ile Asp Thr Met Tyr Arg AsnTyr Asn Asp Glu Val Lys Gln Ala Lys
235 240 245TTT AGC AAC CAA GAA TTA CCC CTT CCT TTT GAT TTA AAA GAG TTT GTC 824Phe Ser Asn Gln Glu Leu Pro Leu Pro Phe Asp Leu Lys Glu Phe Val
250 255 260AAT GCC ATT GCT AAA ACC AAT ACA GAC ATT TTA GAT AGT AGT TTT GAA 872Asn Ala Ile Ala Lys Thr Asn Thr Asp Ile Leu Asp Ser Ser Phe Glu
265 270 275GAC TAT TTA AAA TCT TCC TTA TTT TCT AGC CGA ATG GAT AGT CTA GAT 920Asp Tyr Leu Lys Ser Ser Leu Phe Ser Ser Arg Met Asp Ser Leu Asp
280 285 290TTT AAA ACT CGT ATT AGC ACC ATA AAT ACC GAT AGC ATT TTA CAT AAT 968Phe Lys Thr Arg Ile Ser Thr Ile Asn Thr Asp Ser Ile Leu His Asn295 300 305 310GAT GAT GAC GCT GGG CTT TTA GCC TAC TAT GTC TTT CAT AAG ATG ATT 1016Asp Asp Asp Ala Gly Leu Leu Ala Tyr Tyr Val Phe His Lys Met Ile
315 320 325GAC AGA GCC TTA AAA ATC AAT CGT GGG TTT TTA TGC TTT ATT GAT GAG 1064Asp Arg Ala Leu Lys Ile Asn Arg Gly Phe Leu Cys Phe Ile Asp Glu
330 335 340TTT AAG TCT TAC GCT CAA AAT GAA ATG ATG AAT AAA AAA ATC AAT GAA 1112Phe Lys Ser Tyr Ala Gln Asn Glu Met Met Asn Lys Lys Ile Asn Glu
345 350 355ATC ATT ACT CAA GCT AGA AAG GCT AAT GGG GTG ATT GTT CTA GCC TTA 1160Ile Ile Thr Gln Ala Arg Lys Ala Asn Gly Val Ile Val Leu Ala Leu
360 365 370CAA GAC ATT AAC CAA CTA AGC GAA GTG AGA AAC GCT CAA AGC TTT ATA 1208Gln Asp Ile Asn Gln Leu Ser Glu Val Arg Asn Ala Gln Ser Phe Ile375 380 385 390AAA AAT ATG GGG CAA TTG ATT TTG TAT CCC CAA AGA AAT ATT GAT ACC 1256Lys Asn Met Gly Gln Leu Ile Leu Tyr Pro Gln Arg Asn Ile Asp Thr
395 400 405AAA GAT TTA AAC GAT AAA TTT GGC ATT AGA CTA AGC GAT ACA GAA AAA 1304Lys Asp Leu Asn Asp Lys Phe Gly Ile Arg Leu Ser Asp Thr Glu Lys
410 415 420CAT TTT TTA GAA AAC ACC GCC GTT AAT GAA TAC AAA GTC TTA CTC AAA 1352His Phe Leu Glu Asn Thr Ala Val Asn Glu Tyr Lys Val Leu Leu Lys
425 430 435AAC ATG AAT GAT GGC TCA TCT AAC ATT ATA GAT GTG AGC CTA AGT TCT 1400Asn Met Asn Asp Gly Ser Ser Asn Ile Ile Asp Val Ser Leu Ser Ser
440 445 450TTG GGT AAT TAC CTA CAA ATC TTT AGC TCT AAT TCT AGC ATG GTA GAA 1448Leu Gly Asn Tyr Leu Gln Ile Phe Ser Ser Asn Ser Ser Met Val Glu455 460 465 470CAC ATT GAT AAT CTC ATT AAG CAT TAC CCT AAA ACT TGG CGA GAA GTC 1496His Ile Asp Asn Leu Ile Lys His Tyr Pro Lys Thr Trp Arg Glu Val
475 480 485TTT GTG AGT AAC AAA CAC GAA AAT TTT GAT GAC AAA AAA CAC TTA GAA 1544Phe Val Ser Asn Lys His Glu Asn Phe Asp Asp Lys Lys His Leu Glu
490 495 500AAG GTG CTT AAA TGAAAAACAT CATGCGTTTA GTTTTTGTGA TAGTGGCTAT GT 1598Lys Val Leu Lys
505 (2) sequence 1326 data: (i) sequence characteristics: length (A): 506 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1326: met Gln Glu Cys Ala Leu Asn Leu Val Ile Arg Ala Lys Ser Lys Ala 151015 Lys Leu Asp Lys Ser Leu Lys Glu Ile Leu Ser Leu Leu Asn Asn Ala
20 25 30Gly Leu Gly Ser Val Thr Glu Thr Ile Gly Leu Lys Pro Ser Tyr Phe
35 40 45Ser Phe Phe Pro Asn Asn Ala Asn Ile Asn Pro Arg Met Arg His Gln
50 55 60Thr Ser Gln Val Ile Ala Ser Leu Ile Leu Phe Glu Lys Asn Asn Thr65 70 75 80Gly Phe Arg Ala Asn Ser Trp Gly Asp Met Pro Leu Ser Val Phe Lys
85 90 95Asn Leu Asp His Ser Pro Tyr Leu Phe Asn Phe His Asn Gln Glu Val
100 105 110Lys His Lys Gly Val Leu Ala His Asn Val Ala Arg Val Val Gly His
115 120 125Thr Met Ile Ile Gly Ala Thr Gly Ala Gly Lys Thr Thr Leu Ile Ser
130 135 140Tyr Leu Met Met Ser Ala Leu Lys Tyr Ser Asn Ile Asp Ile Leu Ala145 150 155 160Leu Asp Arg Leu Asn Gly Leu Tyr Ser Phe Thr Lys Tyr Phe Asp Gly
165 170 175Ile Tyr Asn Gln Gly Glu Asn Phe His Ile Asn Pro Phe Ser Leu Glu
180 185 190Asp Ser Ala Thr Asn Arg Ala Phe Leu Leu His Phe Tyr Ala Gln Met
195 200 205Ala Lys Val Asp Ser Tyr Asp Asp His Lys Asp Lys Val Glu Asp Arg
210 215 220Thr Ala Leu Leu Asn Ala Ile Asp Thr Met Tyr Arg Asn Tyr Asn Asp225 230 235 240Glu Val Lys Gln Ala Lys Phe Ser Asn Gln Glu Leu Pro Leu Pro Phe
245 250 255Asp Leu Lys Glu Phe Val Asn Ala Ile Ala Lys Thr Asn Thr Asp Ile
260 265 270Leu Asp Ser Ser Phe Glu Asp Tyr Leu Lys Ser Ser Leu Phe Ser Ser
275 280 285Arg Met Asp Ser Leu Asp Phe Lys Thr Arg Ile Ser Thr Ile Asn Thr
290 295 300Asp Ser Ile Leu His Asn Asp Asp Asp Ala Gly Leu Leu Ala Tyr Tyr305 310 315 320Val Phe His Lys Met Ile Asp Arg Ala Leu Lys Ile Asn Arg Gly Phe
325 330 335Leu Cys Phe Ile Asp Glu Phe Lys Ser Tyr Ala Gln Asn Glu Met Met
340 345 350Asn Lys Lys Ile Asn Glu Ile Ile Thr Gln Ala Arg Lys Ala Asn Gly
355 360 365Val Ile Val Leu Ala Leu Gln Asp Ile Asn Gln Leu Ser Glu Val Arg
370 375 380Asn Ala Gln Ser Phe Ile Lys Asn Met Gly Gln Leu Ile Leu Tyr Pro385 390 395 400Gln Arg Asn Ile Asp Thr Lys Asp Leu Asn Asp Lys Phe Gly Ile Arg
405 410 415Leu Ser Asp Thr Glu Lys His Phe Leu Glu Asn Thr Ala Val Asn Glu
420 425 430Tyr Lys Val Leu Leu Lys Asn Met Asn Asp Gly Ser Ser Asn Ile Ile
435 440 445Asp Val Ser Leu Ser Ser Leu Gly Asn Tyr Leu Gln Ile Phe Ser Ser
450 455 460Asn Ser Ser Met Val Glu His Ile Asp Asn Leu Ile Lys His Tyr Pro465 470 475 480Lys Thr Trp Arg Glu Val Phe Val Ser Asn Lys His Glu Asn Phe Asp
485 490 495Asp Lys Lys His Leu Glu Lys Val Leu Lys
500505 (2) sequence 1327 data: (i) sequence characteristics: length (A): 563bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 509 (D) other information: (xi) Description of the sequence: sequence 1327: CAACTCTTTT TTAAGGGGGA CAC ATG TCT AAT TTG CAA GAA CTT AGA GAG CAT 53
Met Ser Asn Leu Gln Glu Leu Arg Glu His
1 5 10TTA AAA GAA TTA GAA AAT TCC TTT GAA ATA GGC TCT TTT ACT AAA GAA 101Leu Lys Glu Leu Glu Asn Ser Phe Glu Ile Gly Ser Phe Thr Lys Glu
15 20 25AAT ATT AAA GAA TAC GCT AAA TGC TTT TTT ATG AGT TTA AGC ATG TTT 149Asn Ile Lys Glu Tyr Ala Lys Cys Phe Phe Met Ser Leu Ser Met Phe
30 35 40TTA GAA GAA CAA GAA AAA AAC CAA CAA GAA GAG TTT TTA GAA CAA GAT 197Leu Glu Glu Gln Glu Lys Asn Gln Gln Glu Glu Phe Leu Glu Gln Asp
45 50 55ACC AAA GAA AAT CAA GAA GAG CTC ATT AAA AAC ATT CAA ACA AGC ATT 245Thr Lys Glu Asn Gln Glu Glu Leu Ile Lys Asn Ile Gln Thr Ser Ile
60 65 70GCT AAA AAC CAA GAG TTA GAA AAA ATC TCT TTT GAA AAA TGG GAG AAT 293Ala Lys Asn Gln Glu Leu Glu Lys Ile Ser Phe Glu Lys Trp Glu Asn75 80 85 90AAA ATT CAA GAA AGG GTT TTGCCT AAG TTA AAA CGC ATT GTT ACG CAT 341Lys Ile Gln Glu Arg Val Leu Pro Lys Leu Lys Arg Ile Val Thr His
95 100 105AAG TTG CAA GAA AGT ATC ACA TCT AGC ATA AAC ACG CAA TTA GAG AGT 389Lys Leu Gln Glu Ser Ile Thr Ser Ser Ile Asn Thr Gln Leu Glu Ser
110 115 120TTT AAA AAA GAT GAG TTA GAT TTA TCT AGC GTG TTT GAA ATC CAA AGA 437Phe Lys Lys Asp Glu Leu Asp Leu Ser Ser Val Phe Glu Ile Gln Arg
125 130 135AAG AAC ACT CAA ATA GCG TAT AGA TTA GCT ATA GGG GGG CTT ATA GGT 485Lys Asn Thr Gln Ile Ala Tyr Arg Leu Ala Ile Gly Gly Leu Ile Gly
140145150 ATC ATT GCT TTA AGC TCG CAA ATT TGATTATTAA CTCTATACTT CACGCTTTTT 539Ile Ile Ala Leu Ser Ser Gln Ile 155160 AGCCTTTGTG TGTTCTTTTG TAAA 563 (2) sequence 1328 data: (i) sequence characteristics: length (A): 162 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1328: met Ser Asn Leu Gln Glu Leu Arg Glu His Leu Lys Glu Leu Glu Asn 151015 Ser Phe Glu Ile Gly Ser Phe Thr Lys Glu Asn Ile Lys Glu Tyr Ala
20 25 30Lys Cys Phe Phe Met Ser Leu Ser Met Phe Leu Glu Glu Gln Glu Lys
35 40 45Asn Gln Gln Glu Glu Phe Leu Glu Gln Asp Thr Lys Glu Asn Gln Glu
50 55 60Glu Leu Ile Lys Asn Ile Gln Thr Ser Ile Ala Lys Asn Gln Glu Leu65 70 75 80Glu Lys Ile Ser Phe Glu Lys Trp Glu Asn Lys Ile Gln Glu Arg Val
85 90 95Leu Pro Lys Leu Lys Arg Ile Val Thr His Lys Leu Gln Glu Ser Ile
100 105 110Thr Ser Ser Ile Asn Thr Gln Leu Glu Ser Phe Lys Lys Asp Glu Leu
115 120 125Asp Leu Ser Ser Val Phe Glu Ile Gln Arg Lys Asn Thr Gln Ile Ala
130135140 Tyr Arg Leu Ala Ile Gly Gly Leu Ile Gly Ile Ile Ala Leu Ser Ser 145150155160 Gln Ile (2) sequence 1329 data: (i) sequence characteristics: length (A): 3222bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 3186 (D) other information: (xi) Description of the sequence: sequence 1329: CCTTAAATCT AAGGGGTGTG C ATG CCA TAC AAT GAA ATC ACA AGG GTT CAA 51
Met Pro Tyr Asn Glu Ile Thr Arg Val Gln
1 5 10ATC CCT GCC TTA ATG CAT TTA GCC AAG TTG GGC TAT GAT TTT ATC CCC 99Ile Pro Ala Leu Met His Leu Ala Lys Leu Gly Tyr Asp Phe Ile Pro
15 20 25ACT AAT TCT AAA GAA AAT AAG CCC AAC CTA GAC ACC GCC ACC AAC ATT 147Thr Asn Ser Lys Glu Asn Lys Pro Asn Leu Asp Thr Ala Thr Asn Ile
30 35 40TTA ACC AAT AGT TTC ACT AAA TCC TTT GAG CGG TTA AAC CCC ACT AAA 195Leu Thr Asn Ser Phe Thr Lys Ser Phe Glu Arg Leu Asn Pro Thr Lys
45 50 55AAC GCA CAA GAA ACG CTT GCT GAA ATG AAA AAA CGC TTG AAT TGC GAT 243Asn Ala Gln Glu Thr Leu Ala Glu Met Lys Lys Arg Leu Asn Cys Asp
60 65 70GAT TTG GGC AAA AGC TTT TAT GAA TAC TTG CTC AAA AGC GAG AAT CAA 291Asp Leu Gly Lys Ser Phe Tyr Glu Tyr Leu Leu Lys Ser Glu Asn Gln75 80 85 90ATC ATA GAC TTT GAT AAC CCT AAC AAC AAT CTT TAT GAA ATG ATG ACT 339Ile Ile Asp Phe Asp Asn Pro Asn Asn Asn Leu Tyr Glu Met Met Thr
95 100 105GAA TTA CCC TAC AAA TCT TTT AGG CCT GAC ACC ACC CTT TTT ATC AAT 387Glu Leu Pro Tyr Lys Ser Phe Arg Pro Asp Thr Thr Leu Phe Ile Asn
110 115 120GGC TTG CCT TTG GTG AAT ATA GAA GTT AAA CAG CCT TAC GCC AAA AAA 435Gly Leu Pro Leu Val Asn Ile Glu Val Lys Gln Pro Tyr Ala Lys Lys
125 130 135GGC ATT AAA GAA GAA AGA GAT CGC CAC ATC AAA CGC TAT GAA AAC CCT 483Gly Ile Lys Glu Glu Arg Asp Arg His Ile Lys Arg Tyr Glu Asn Pro
140 145 150GAA AAC AAA GTT TTT TAT AAT CTC GCG CAA ATC TGG CTT TTT AGC GAT 531Glu Asn Lys Val Phe Tyr Asn Leu Ala Gln Ile Trp Leu Phe Ser Asp155 160 165 170AAC TTA CCC TAT GAT GAA AAC AAA CCC GAT CAA GGC GCG TTT TAT AGC 579Asn Leu Pro Tyr Asp Glu Asn Lys Pro Asp Gln Gly Ala Phe Tyr Ser
175 180 185GCT TCT TAT TCG CCC ATT TTC CAA CGC TTT GTT GAA GCT CAT AGG CTA 627Ala Ser Tyr Ser Pro Ile Phe Gln Arg Phe Val Glu Ala His Arg Leu
190 195 200GAT ATT WCC CCC SSN CCC CSC CAA AAA AAT GAT CAA AAT CAT CAA AAC 675Asp Ile Xaa Pro Xaa Pro Xaa Gln Lys Asn Asp Gln Asn His Gln Asn
205 210 215GAT CAA AAT CAT CGA TCG CTT GAA GAA ATT CAA AAA AGC GTC TTA AAC 723Asp Gln Asn His Arg Ser Leu Glu Glu Ile Gln Lys Ser Val Leu Asn
220225 230GAA TTT AAC CTT AAA GAC ACC GAC ACC CCA AAA AGC CCT AAA GAC ACC 771Glu Phe Asn Leu Lys Asp Thr Asp Thr Pro Lys Ser Pro Lys Asp Thr235 240 245 250CCC ACA AAC TCC CTT TTA ACT TCG TTT TGC TCT CCA AAA AGG CTT TGC 819Pro Thr Asn Ser Leu Leu Thr Ser Phe Cys Ser Pro Lys Arg Leu Cys
255 260 265TTT ATC CTA AAA TAC GGC ATC AGT TTC TTA AAA GAA AAA TCA GAG TTT 867Phe Ile Leu Lys Tyr Gly Ile Ser Phe Leu Lys Glu Lys Ser Glu Phe
270 275 280AAA AAA CAC GTT TGG CGT TAT GCG CAG ATG TTT GCG AGC TTG AAC GTT 915Lys Lys His Val Trp Arg Tyr Ala Gln Met Phe Ala Ser Leu Asn Val
285 290 295TTA AAA GAA TTG CAA AAG CAT TAT GGA ACA AAC CAA AAC CTA AAA GAT 963Leu Lys Glu Leu Gln Lys His Tyr Gly Thr Asn Gln Asn Leu Lys Asp
300 305 310CCC CTA AAA GGC ATC ATC TGG CAC ACG CAA GGC AGC GGT AAA ACC GCC 1011Pro Leu Lys Gly Ile Ile Trp His Thr Gln Gly Ser Gly Lys Thr Ala315 320 325 330TTA ACC TAC CAC TTA ACC AAA CTC ATC AGA GAC TTT TTT AGC CGA TCC 1059Leu Thr Tyr His Leu Thr Lys Leu Ile Arg Asp Phe Phe Ser Arg Ser
335 340 345AAC CTA AAC AAA AAG ACT AAA TTT TAT TTT ATT GTG GAC AGG TTG GAT 1107Asn Leu Asn Lys Lys Thr Lys Phe Tyr Phe Ile Val Asp Arg Leu Asp
350 355 360TTA TTG GAG CAA GCC AAA AAC GAG TTT TTA AAA AGA GGC CTT TGT GTG 1155Leu Leu Glu Gln Ala Lys Asn Glu Phe Leu Lys Arg Gly Leu Cys Val
365 370 375CAT GAG GCA GAA AAT AAA GAG GAT TTG AGC CAA AAA TTA AAA AGC TCT 1203His Glu Ala Glu Asn Lys Glu Asp Leu Ser Gln Lys Leu Lys Ser Ser
380 385 390AGC GTT TTT GAA GGC TCT CAA GGG AAT GAT GAA ATC ATC GTT GTG AAT 1251Ser Val Phe Glu Gly Ser Gln Gly Asn Asp Glu Ile Ile Val Val Asn395 400 405 410ATC CAA AAA TTC AAA GCC CCC AAT GAA GAA AAA TCC CCC AAT GAA GAC 1299Ile Gln Lys Phe Lys Ala Pro Asn Glu Glu Lys Ser Pro Asn Glu Asp
415 420 425CCC TCT AAT AGC GCT CCT AAA GAA ATC ATT TCT AAA ACA GAA TTA CAA 1347Pro Ser Asn Ser Ala Pro Lys Glu Ile Ile Ser Lys Thr Glu Leu Gln
430 435 440GAA TCC ATT CAA AAC AGC CGC AAT TTA CAA AGG GTG TTT ATC ATA GAT 1395Glu Ser Ile Gln Asn Ser Arg Asn Leu Gln Arg Val Phe Ile Ile Asp
445 450 455GAA GCC CAC AGG AGC TAC GAT CCT AAA GGT TGC TTT TAC GCT AAT TTG 1443Glu Ala His Arg Ser Tyr Asp Pro Lys Gly Cys Phe Tyr Ala Asn Leu
460 465 470ATA GAA TGC GAC AAG ACA GCA ATT AAA ATC GCC CTC ACA GGC ACG CCC 1491Ile Glu Cys Asp Lys Thr Ala Ile Lys Ile Ala Leu Thr Gly Thr Pro475 480 485 490CTA TTA GAA GAC AAC GCG CAA GAT AAA GCC ACT AAA AAC ACT TTT GGC 1539Leu Leu Glu Asp Asn Ala Gln Asp Lys Ala Thr Lys Asn Thr Phe Gly
495 500 505AAC TAC TTG CAC ACC TAT TCT TAT ACA GAA TCC ATT AAA GAC AGA CAC 1587Asn Tyr Leu His Thr Tyr Ser Tyr Thr Glu Ser Ile Lys Asp Arg His
510 515 520ACC CTA AAA CTC CAG TTA GAA AGC ATT GAA ACG AGC TAT AAA GAA AAA 1635Thr Leu Lys Leu Gln Leu Glu Ser Ile Glu Thr Ser Tyr Lys Glu Lys
525 530 535TTA CAA GAA ATC TAT CGC CTT TTA CAA GAA AGC ATC ACT ATT GAA GAC 1683Leu Gln Glu Ile Tyr Arg Leu Leu Gln Glu Ser Ile Thr Ile Glu Asp
540 545 550ACA GAA GTT AAA AAA GAA ACG ATT TTT AAC GAT GAA AAA TAC ATT AAC 1731Thr Glu Val Lys Lys Glu Thr Ile Phe Asn Asp Glu Lys Tyr Ile Asn555 560 565 570GCC ATG CTC TAT TAT ATC ATT AGA GAT TTA TTG GAT TTT AGG CGT TTG 1779Ala Met Leu Tyr Tyr Ile Ile Arg Asp Leu Leu Asp Phe Arg Arg Leu
575 580 585AAT GAT AAT GAA CGC TTA AAG GCT ATG GTG GTT TGT TTT TCT AGC AAG 1827Asn Asp Asn Glu Arg Leu Lys Ala Met Val Val Cys Phe Ser Ser Lys
590 595 600CAA GCC AGA TTA GCT GAT TGT CTT TTT AAT GAA GTC CAA GAA AAA GTC 1875Gln Ala Arg Leu Ala Asp Cys Leu Phe Asn Glu Val Gln Glu Lys Val
605 610 615TTA CAA GAA AAC CCC AAC CTA AGG ATT TTA AAC AAA CTC AAA TCC AGC 1923Leu Gln Glu Asn Pro Asn Leu Arg Ile Leu Asn Lys Leu Lys Ser Ser
620 625 630CTG ATT TTG CAT GAT GAA CAA GAA GTC AAA GAA AAG GTT CAT TCT TTC 1971Leu Ile Leu His Asp Glu Gln Glu Val Lys Glu Lys Val His Ser Phe635 640 645 650AAA CAT GAA GAT ACC GAT ATA GTC TTT GTG TTT AAC ATG CTT TTA ACC 2019Lys His Glu Asp Thr Asp Ile Val Phe Val Phe Asn Met Leu Leu Thr
655 660 665GGC TTT GAT TTA CCC AGT CTC AAA CGC CTT TAT ATC CAC AGA GAA TTA 2067Gly Phe Asp Leu Pro Ser Leu Lys Arg Leu Tyr Ile His Arg Glu Leu
670 675 680AAA GAT CAC AAT TTG CTC CAA GCC CTA GCC AGA GTG AAT CGC TCC TAT 2115Lys Asp His Asn Leu Leu Gln Ala Leu Ala Arg Val Asn Arg Ser Tyr
685 690 695AAA AAC ATG TCT TTT GGC TAC CTT ATA GAT TTT GTA GGC ATT CAA GAA 2163Lys Asn Met Ser Phe Gly Tyr Leu Ile Asp Phe Val Gly Ile Gln Glu
700 705 710AAT TTT GAC AAA ACG ACT GAT GAT TAC TTG AAA GAA TTA AAC CGA TTC 2211Asn Phe Asp Lys Thr Thr Asp Asp Tyr Leu Lys Glu Leu Asn Arg Phe715 720 725 730AAT CAA AGC GGT GCC AAT AGC GAT TCT CAT ATC AAA GAC ATG TTT GCG 2259Asn Gln Ser Gly Ala Asn Ser Asp Ser His Ile Lys Asp Met Phe Ala
735 740 745GAT CGT AAG ACT TTA GAA GAA GAC ATT AAA AAC GCC TAT GAT GAT CTT 2307Asp Arg Lys Thr Leu Glu Glu Asp Ile Lys Asn Ala Tyr Asp Asp Leu
750 755 760TTT GAT TAC CCC ATT GAC GAT ATA GAG GGC ATG ACT AGC GCC ATT GTC 2355Phe Asp Tyr Pro Ile Asp Asp Ile Glu Gly Met Thr Ser Ala Ile Val
765 770 775AGC ATG AGC GCA ATG AAC GAG CTT GTA AAA GTC TCA CGC GCC ATT AAC 2403Ser Met Ser Ala Met Asn Glu Leu Val Lys Val Ser Arg Ala Ile Asn
780 785 790ACG CTC AAA GAG CGC TAC AAT TTA ATC CGC ACT TCT AAT GAT AAA AAA 2451Thr Leu Lys Glu Arg Tyr Asn Leu Ile Arg Thr Ser Asn Asp Lys Lys795 800 805 810ATC CTT TCA CTA AAA GAA AAA ATT GAT ATT GAA AAG ATC CAT AAA ATC 2499Ile Leu Ser Leu Lys Glu Lys Ile Asp Ile Glu Lys Ile His Lys Ile
815 820 825TCT TCA ATG CTT CAT CAA AAA GCC AAA CACCTC CAT GCG TTA AAG AAT 2547Ser Ser Met Leu His Gln Lys Ala Lys His Leu His Ala Leu Lys Asn
830 835 840ATC AAT GAG CCT AAA AAC CCA AAC GAT TTA ATG ATT TTA GAA GAC CTC 2595Ile Asn Glu Pro Lys Asn Pro Asn Asp Leu Met Ile Leu Glu Asp Leu
845 850 855ATC GCT CTT TTA GAC TTT AAA ATA GAG TTT AAA GAA CGC AAA GAA TTA 2643Ile Ala Leu Leu Asp Phe Lys Ile Glu Phe Lys Glu Arg Lys Glu Leu
860 865 870CGC TTT AAA GAA CAA GAA GAG ATT ACC ACC AAA CAA AAG CAA GCT AAA 2691Arg Phe Lys Glu Gln Glu Glu Ile Thr Thr Lys Gln Lys Gln Ala Lys875 880 885 890GAG ATT TTA GAA AAA ATC CCG GAT CAA CAA GAT AAA GAA ATC CAA AAG 2739Glu Ile Leu Glu Lys Ile Pro Asp Gln Gln Asp Lys Glu Ile Gln Lys
895 900 905TTT TAC AAA GAC TTT TCA AAA TTA CTC CAA ACG CCC ACA ACA AGC CAG 2787Phe Tyr Lys Asp Phe Ser Lys Leu Leu Gln Thr Pro Thr Thr Ser Gln
910 915 920AAT TTT GAG GAA ATT TCT CAT TCC TAT GAT GCG ATC ATT TCA CAA CTC 2835Asn Phe Glu Glu Ile Ser His Ser Tyr Asp Ala Ile Ile Ser Gln Leu
925 930 935AAA CAA CAC AAA GAA CAA ACC ACC CAC TTA TTA AAC AAA TAC GAT AAT 2883Lys Gln His Lys Glu Gln Thr Thr His Leu Leu Asn Lys Tyr Asp Asn
940 945 950GAT TTG TCT TAT GCG ATC ACG AAC AAA CGC CTT CAT AAG CAC CTT ATG 2931Asp Leu Ser Tyr Ala Ile Thr Asn Lys Arg Leu His Lys His Leu Met955 960 965 970GAA CAA AAC ATT TCT AAC TCA GCG GGA ATT TTC ACG CTT TTA AGC GCC 2979Glu Gln Asn Ile Ser Asn Ser Ala Gly Ile Phe Thr Leu Leu Ser Ala
975 980 985 TTA AAA AAA GCT ATT GAT GCG CGT ATT TTT AAG CGT CAA GAA ATC TTA 3027 Leu Lys Lys Ala Ile Asp Ala Arg Ile Phe Lys Arg Gln Glu Ile Leu
990 995 1000 AAC GAA GAG TAT TAC CTA AAA AAT GCC ATA AAA GCA GAA TTA AAT AAC 3075 Asn Glu Glu Tyr Tyr Leu Lys Asn Ala Ile Lys Ala Glu Leu Asn Asn
1005 1010 1015 GCT TTC AAA AAA GAC CCC TCC TTA AAA GAT TTA GAA AAA GAA AAA GAA 3123 Ala Phe Lys Lys Asp Pro Ser Leu Lys Asp Leu Glu Lys Glu Lys Glu
1020 1025 1030 CTT ATC ATT CAA ACC CTT TTT AAC GAA CTC ACA CAA AAC CAC CAT CAA 3171 Leu Ile Ile Gln Thr Leu Phe Asn Glu Leu Thr Gln Asn His His Gln1035 1040 1045 1050 GGA AAT CCG CAT GCC TAATAACGCT TTATTGCAAA TCAAACAAGA CACCCT 3222 Gly Asn Pro His Ala
1055 (2) sequence 1330 data: (i) sequence characteristics: length (A): 1055 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1330: met Pro Tyr Asn Glu Ile Thr Arg Val Gln Ile Pro Ala Leu Met His 151015 Leu Ala Lys Leu Gly Tyr Asp Phe Ile Pro Thr Asn Ser Lys Glu Asn
20 25 30Lys Pro Asn Leu Asp Thr Ala Thr Asn Ile Leu Thr Asn Ser Phe Thr
35 40 45Lys Ser Phe Glu Arg Leu Asn Pro Thr Lys Asn Ala Gln Glu Thr Leu
50 55 60Ala Glu Met Lys Lys Arg Leu Asn Cys Asp Asp Leu Gly Lys Ser Phe65 70 75 80Tyr Glu Tyr Leu Leu Lys Ser Glu Asn Gln Ile Ile Asp PheAsp Asn
85 90 95Pro Asn Asn Asn Leu Tyr Glu Met Met Thr Glu Leu Pro Tyr Lys Ser
100 105 110Phe Arg Pro Asp Thr Thr Leu Phe Ile Asn Gly Leu Pro Leu Val Asn
115 120 125Ile Glu Val Lys Gln Pro Tyr Ala Lys Lys Gly Ile Lys Glu Glu Arg
130 135 140Asp Arg His Ile Lys Arg Tyr Glu Asn Pro Glu Asn Lys Val Phe Tyr145 150 155 160Asn Leu Ala Gln Ile Trp Leu Phe Ser Asp Asn Leu Pro Tyr Asp Glu
165 170 175Asn Lys Pro Asp Gln Gly Ala Phe Tyr Ser Ala Ser Tyr Ser Pro Ile
180 185 190Phe Gln Arg Phe Val Glu Ala His Arg Leu Asp Ile Xaa Pro Xaa Pro
195 200 205Xaa Gln Lys Asn Asp Gln Asn His Gln Asn Asp Gln Asn His Arg Ser
210 215 220Leu Glu Glu Ile Gln Lys Ser Val Leu Asn Glu Phe Asn Leu Lys Asp225 230 235 240Thr Asp Thr Pro Lys Ser Pro Lys Asp Thr Pro Thr Asn Ser Leu Leu
245 250 255Thr Ser Phe Cys Ser Pro Lys Arg Leu Cys Phe Ile Leu Lys Tyr Gly
260 265 270Ile Ser Phe Leu Lys Glu Lys Ser Glu Phe Lys Lys His Val Trp Arg
275 280 285Tyr Ala Gln Met Phe Ala Ser Leu Asn Val Leu Lys Glu Leu Gln Lys
290 295 300His Tyr Gly Thr Asn Gln Asn Leu Lys Asp Pro Leu LysGly Ile Ile305 310 315 320Trp His Thr Gln Gly Ser Gly Lys Thr Ala Leu Thr Tyr His Leu Thr
325 330 335Lys Leu Ile Arg Asp Phe Phe Ser Arg Ser Asn Leu Asn Lys Lys Thr
340 345 350Lys Phe Tyr Phe Ile Val Asp Arg Leu Asp Leu Leu Glu Gln Ala Lys
355 360 365Asn Glu Phe Leu Lys Arg Gly Leu Cys Val His Glu Ala Glu Asn Lys
370 375 380Glu Asp Leu Ser Gln Lys Leu Lys Ser Ser Ser Val Phe Glu Gly Ser385 390 395 400Gln Gly Asn Asp Glu Ile Ile Val Val Asn Ile Gln Lys Phe Lys Ala
405 410 415Pro Asn Glu Glu Lys Ser Pro Asn Glu Asp Pro Ser Asn Ser Ala Pro
420 425 430Lys Glu Ile Ile Ser Lys Thr Glu Leu Gln Glu Ser Ile Gln Asn Ser
435 440 445Arg Asn Leu Gln Arg Val Phe Ile Ile Asp Glu Ala His Arg Ser Tyr
450 455 460Asp Pro Lys Gly Cys Phe Tyr Ala Asn Leu Ile Glu Cys Asp Lys Thr465 470 475 480Ala Ile Lys Ile Ala Leu Thr Gly Thr Pro Leu Leu Glu Asp Asn Ala
485 490 495Gln Asp Lys Ala Thr Lys Asn Thr Phe Gly Asn Tyr Leu His Thr Tyr
500 505 510Ser Tyr Thr Glu Ser Ile Lys Asp Arg His Thr Leu Lys Leu Gln Leu
515 520 525Glu Ser Ile Glu Thr Ser Tyr LysGlu Lys Leu Gln Glu Ile Tyr Arg
530 535 540Leu Leu Gln Glu Ser Ile Thr Ile Glu Asp Thr Glu Val Lys Lys Glu545 550 555 560Thr Ile Phe Asn Asp Glu Lys Tyr Ile Asn Ala Met Leu Tyr Tyr Ile
565 570 575Ile Arg Asp Leu Leu Asp Phe Arg Arg Leu Asn Asp Asn Glu Arg Leu
580 585 590Lys Ala Met Val Val Cys Phe Ser Ser Lys Gln Ala Arg Leu Ala Asp
595 600 605Cys Leu Phe Asn Glu Val Gln Glu Lys Val Leu Gln Glu Asn Pro Asn
610 615 620Leu Arg Ile Leu Asn Lys Leu Lys Ser Ser Leu Ile Leu His Asp Glu625 630 635 640Gln Glu Val Lys Glu Lys Val His Ser Phe Lys His Glu Asp Thr Asp
645 650 655Ile Val Phe Val Phe Asn Met Leu Leu Thr Gly Phe Asp Leu Pro Ser
660 665 670Leu Lys Arg Leu Tyr Ile His Arg Glu Leu Lys Asp His Asn Leu Leu
675 680 685Gln Ala Leu Ala Arg Val Asn Arg Ser Tyr Lys Asn Met Ser Phe Gly
690 695 700Tyr Leu Ile Asp Phe Val Gly Ile Gln Glu Asn Phe Asp Lys Thr Thr705 710 715 720Asp Asp Tyr Leu Lys Glu Leu Asn Arg Phe Asn Gln Ser Gly Ala Asn
725 730 735Ser Asp Ser His Ile Lys Asp Met Phe Ala Asp Arg Lys Thr Leu Glu
740 745 750Glu Asp Ile Lys Asn Ala Tyr Asp Asp Leu Phe Asp Tyr Pro Ile Asp
755 760 765Asp Ile Glu Gly Met Thr Ser Ala Ile Val Ser Met Ser Ala Met Asn
770 775 780Glu Leu Val Lys Val Ser Arg Ala Ile Asn Thr Leu Lys Glu Arg Tyr785 790 795 800Asn Leu Ile Arg Thr Ser Asn Asp Lys Lys Ile Leu Ser Leu Lys Glu
805 810 815Lys Ile Asp Ile Glu Lys Ile His Lys Ile Ser Ser Met Leu His Gln
820 825 830Lys Ala Lys His Leu His Ala Leu Lys Asn Ile Asn Glu Pro Lys Asn
835 840 845Pro Asn Asp Leu Met Ile Leu Glu Asp Leu Ile Ala Leu Leu Asp Phe
850 855 860Lys Ile Glu Phe Lys Glu Arg Lys Glu Leu Arg Phe Lys Glu Gln Glu865 870 875 880Glu Ile Thr Thr Lys Gln Lys Gln Ala Lys Glu Ile Leu Glu Lys Ile
885 890 895Pro Asp Gln Gln Asp Lys Glu Ile Gln Lys Phe Tyr Lys Asp Phe Ser
900 905 910Lys Leu Leu Gln Thr Pro Thr Thr Ser Gln Asn Phe Glu Glu Ile Ser
915 920 925His Ser Tyr Asp Ala Ile Ile Ser Gln Leu Lys Gln His Lys Glu Gln
930 935 940Thr Thr His Leu Leu Asn Lys Tyr Asp Asn Asp Leu Ser Tyr Ala Ile945 950 955 960Thr Asn Lys Arg Leu His Lys His Leu Met Glu Gln Asn Ile Ser Asn
965 970 975Ser Ala Gly Ile Phe Thr Leu Leu Ser Ala Leu Lys Lys Ala Ile Asp
980 985 990Ala Arg Ile Phe Lys Arg Gln Glu Ile Leu Asn Glu Glu Tyr Tyr Leu
995 1000 1005Lys Asn Ala Ile Lys Ala Glu Leu Asn Asn Ala Phe Lys Lys Asp Pro 1010 1015 1020Ser Leu Lys Asp Leu Glu Lys Glu Lys Glu Leu Ile Ile Gln Thr Leu025 1030 1035 1040Phe Asn Glu Leu Thr Gln Asn His His Gln Gly Asn Pro His Ala
104510501055 (2) sequence 1331 data: (i) sequence characteristics: length (A): 574bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 511 (D) other information: (xi) Description of the sequence: sequence 1331: TAGAAGAATT TGAAAGGTTG CTCGC ATG CAA AGA GAA TTA AGG CTT TTA AAT 52
Met Gln Arg Glu Leu Arg Leu Leu Asn
1 5AAC AAG CAT TGC ATG GAA TAC TTG CAA TTT CTG TCC AAA AAC CAT TTG 100Asn Lys His Cys Met Glu Tyr Leu Gln Phe Leu Ser Lys Asn His Leu10 15 20 25AGT TTT AAC CTT TTG TGC GAA AGA GAT GCG ATT GAT TTT TCC CCC AAG 148Ser Phe Asn Leu Leu Cys Glu Arg Asp Ala Ile Asp Phe Ser Pro Lys
30 35 40CTC CCT AAA GAA ATT CAT GAA AAA TTC GGC GCG TTA GTG CTA TTT GTT 196Leu Pro Lys Glu Ile His Glu Lys Phe Gly Ala Leu Val Leu Phe Val
45 50 55TTA GCC GGA TAC ACC TTA GAA AGC TTG ATA ATT GAT ACA AAA AGC GTG 244Leu Ala Gly Tyr Thr Leu Glu Ser Leu Ile Ile Asp Thr Lys Ser Val
60 6570CAA TTT GAA GCC GGG TTT GGC CCT AAT AAC ATT GGC AGT GTG GTT CAA 292Gln Phe Glu Ala Gly Phe Gly Pro Asn Asn Ile Gly Ser Val Val Gln
75 80 85GTA AAA CTT CCT GGC ATC ATT CAA ATC CTT ATC AAA GAA AAA AAT GAA 340Val Lys Leu Pro Gly Ile Ile Gln Ile Leu Ile Lys Glu Lys Asn Glu90 95 100 105AAT GCC GTT TTA TTC AAT CGT TGC GAT TCG CTT GAA TTG TTT CAA AAA 388Asn Ala Val Leu Phe Asn Arg Cys Asp Ser Leu Glu Leu Phe Gln Lys
110 115 120GAA GAT TCA ATC GCG CAA GAG CCA AAA AAA GAC GAG CGG GAG TCT AAA 436Glu Asp Ser Ile Ala Gln Glu Pro Lys Lys Asp Glu Arg Glu Ser Lys
125 130 135GAA TGG CTG GAT TCT AAA GAG GCT CTT TTT TCC AAT TCC AAA AAC CGC 484Glu Trp Leu Asp Ser Lys Glu Ala Leu Phe Ser Asn Ser Lys Asn Arg
140 145 150GCG ATT TTA GAA AAT CTG CAC AAA AGC TAAAGGAATC ATTGATGAGC GTTTTGA 538Ala Ile Leu Glu Asn Leu His Lys Ser
155160 AATTGCATGT AAAAGTCTTT CGTTTTGAAA CCAATA 574 (2) sequence 1332 data: (i) sequence characteristics: length (A): 162 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1332: met Gln Arg Glu Leu Arg Leu Leu Asn Asn Lys His Cys Met Glu Tyr 151015 Leu Gln Phe Leu Ser Lys Asn His Leu Ser Phe Asn Leu Leu Cys Glu
20 25 30Arg Asp Ala Ile Asp Phe Ser Pro Lys Leu Pro Lys Glu Ile His Glu
35 40 45Lys Phe Gly Ala Leu Val Leu Phe Val Leu Ala Gly Tyr Thr Leu Glu
50 5560Ser Leu Ile Ile Asp Thr Lys Ser Val Gln Phe Glu Ala Gly Phe Gly65 70 75 80Pro Asn Asn Ile Gly Ser Val Val Gln Val Lys Leu Pro Gly Ile Ile
85 90 95Gln Ile Leu Ile Lys Glu Lys Asn Glu Asn Ala Val Leu Phe Asn Arg
100 105 110Cys Asp Ser Leu Glu Leu Phe Gln Lys Glu Asp Ser Ile Ala Gln Glu
115 120 125Pro Lys Lys Asp Glu Arg Glu Ser Lys Glu Trp Leu Asp Ser Lys Glu
130 135 140Ala Leu Phe Ser Asn Ser Lys Asn Arg Ala Ile Leu Glu Asn Leu His145 150 155 160Lys Ser
(2) Data of sequence 1333:
(i) sequence characteristics:
(A) length: 1697bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(ix) Is characterized in that:
(A) name/keyword: coding sequence
(B) Position: 14...1648
(D) Other information:
(xi) Description of the sequence: sequence 1333: TTTAGGGGGG TAA ATG CCT TCA AAC GCT CTT TTG ATT GAA GAA ATC ACT 49
Met Pro Ser Asn Ala Leu Leu Ile Glu Glu Ile Thr
1 5 10CAT TTA ATC AAT GTT TCT CAT AGT AGC GTG CAT AAT TGG ATC AAA ACC 97His Leu Ile Asn Val Ser His Ser Ser ValHis Asn Trp Ile Lys Thr
15 20 25AAT CTT TTA GAG AAA CTA GAA ATT GAT CAT AAA ATT TAT GTG AAA ACG 145Asn Leu Leu Glu Lys Leu Glu Ile Asp His Lys Ile Tyr Val Lys Thr
30 35 40AGT TCT TTT TTA GAT TTT TGC CGC AAC CAT TTA GGG AAA AAC AAG CTT 193Ser Ser Phe Leu Asp Phe Cys Arg Asn His Leu Gly Lys Asn Lys Leu45 50 55 60AAC AAA TAC GCT AAC AAA TCC TTA AAA GGC GTG CAT AAC CAT CAA GAA 241Asn Lys Tyr Ala Asn Lys Ser Leu Lys Gly Val His Asn His Gln Glu
65 70 75TTG ATT TTA AAA TAC CTA GAA ATA TTA GAA AAT AGC TCT GAT CTA GAA 289Leu Ile Leu Lys Tyr Leu Glu Ile Leu Glu Asn Ser Ser Asp Leu Glu
80 85 90AAG TTG GGT TCT TAT TAT GAA GAA GAG CTT TCT AAC GCC ACC AGA AAT 337Lys Leu Gly Ser Tyr Tyr Glu Glu Glu Leu Ser Asn Ala Thr Arg Asn
95 100 105TTA GAA GGC ATT TAC TAC ACT CCT AAC AGG ATA GTA GAA CAA CTT TTC 385Leu Glu Gly Ile Tyr Tyr Thr Pro Asn Arg Ile Val Glu Gln Leu Phe
110 115 120ACC CTC CCT AAA GAT TTT GAT GTC TCT CAA GCG ATT TTT TGC GAT CCG 433Thr Leu Pro Lys Asp Phe Asp Val Ser Gln Ala Ile Phe Cys Asp Pro125 130 135 140GCT GTG GGG AGT GGG AAT TTT ATC ATG CAT GCT TTA AAA CTG GGT TTT 481Ala Val Gly Ser Gly Asn Phe Ile Met His Ala Leu Lys Leu Gly Phe
145 150 155AAG GTT GAA AAC ATT TAT GGC TAT GAT ACG GAC GCT TTT GCT GTC GCT 529Lys Val Glu Asn Ile Tyr Gly Tyr Asp Thr Asp Ala Phe Ala Val Ala
160165 170TTG ACT AAA AAG CGT ATT AAA GAG CGT TAT CAT TTA GAT TGC CTT AAT 577Leu Thr Lys Lys Arg Tle Lys Glu Arg Tyr His Leu Asp Cys Leu Asn
175 180 185ATT GTG CAA AAA GAT TTT TTA AAT TTA AAA CAC ACC CCG CAA TTT GAT 625Ile Val Gln Lys Asp Phe Leu Asn Leu Lys His Thr Pro Gln Phe Asp
190 195 200TGC ATT TTC ACT AAC CCG CCA TGG GGC AAG AAA TAC AAT CAA AAC CAA 673Cys Ile Phe Thr Asn Pro Pro Trp Gly Lys Lys Tyr Asn Gln Asn Gln205 210 215 220AAA GAA AAT TTT AAA CAG CAA TTC AAC CTC TCT CAA AGC CTA GAT AGC 721Lys Glu Asn Phe Lys Gln Gln Phe Asn Leu Ser Gln Ser Leu Asp Ser
225 230 235GCG TCG CTC TTT TTT ATA GCG AGT TTG AAT TGT TTA AAA GAA AAC GCT 769Ala Ser Leu Phe Phe Ile Ala Ser Leu Asn Cys Leu Lys Glu Asn Ala
240 245 250CAT TTG GGG TTA TTA TTA CCC GAA AGT TGT TTG AAT ATT GAT GCG TTT 817His Leu Gly Leu Leu Leu Pro Glu Ser Cys Leu Asn Ile Asp Ala Phe
255 260 265AAA AAA ATG CGA GAA ATG GCT TTA AAG TTT CAC ATT AGA AGC CTG ATT 865Lys Lys Met Arg Glu Met Ala Leu Lys Phe His Ile Arg Ser Leu Ile
270 275 280GAT TTT GAC AAA CCT TTT AAA AAT CTA ATG ACT AAG GCT GTG GGT TTG 913Asp Phe Asp Lys Pro Phe Lys Asn Leu Met Thr Lys Ala Val Gly Leu285 290 295 300GCG CTT AAA AAA ACC CCT AAT AAG GAT CAA AAA ATC TCA TGC TTT TAT 961Ala Leu Lys Lys Thr Pro Asn Lys Asp Gln Lys Ile Ser Cys Phe Tyr
305 310 315CAA AAT AGC AAG TTC AAA CGC TCG CCC TCT TCT TTT TTT AAC AAC CCT 1009Gln Asn Ser Lys Phe Lys Arg Ser Pro Ser Ser Phe Phe Asn Asn Pro
320 325 330AAA AAG ATT TTT AAT ATC CAT TGC TCT AGC AAA GAA AAT AAA ATT TTA 1057Lys Lys Ile Phe Asn Ile His Cys Ser Ser Lys Glu Asn Lys Ile Leu
335 340 345GAC CAC CTT TTT TCC CTC CCT CAT ATG ACT TTA AAA AAT AAC GCT CAT 1105Asp His Leu Phe Ser Leu Pro His Met Thr Leu Lys Asn Asn Ala His
350 355 360TTT GCT TTA GGG ATT GTT ACA GGC AAC AAT AAA GAA AAA TTA CAC CCC 1153Phe Ala Leu Gly Ile Val Thr Gly Asn Asn Lys Glu Lys Leu His Pro365 370 375 380AAA CAA GAA AAA AAT ACC ATT CCC ATT TTT AGG GGT TCA GAT ATT TTA 1201Lys Gln Glu Lys Asn Thr Ile Pro Ile Phe Arg Gly Ser Asp Ile Leu
385 390 395AAA GAC GGA TTA AAA GCC CCT AGC CAA TTC ATT AAC GCT GGT TTA AAA 1249Lys Asp Gly Leu Lys Ala Pro Ser Gln Phe Ile Asn Ala Gly Leu Lys
400 405 410GAC TGC CAG CAA GTC GCC CCC TTA AGC CTT TAT CAA GCT AGA GAA AAA 1297Asp Cys Gln Gln Val Ala Pro Leu Ser Leu Tyr Gln Ala Arg Glu Lys
415 420 425ATC GTG TAT AAA TTC ATT TCT TCA AAG CTT GTC TTT TTT TAT GAC AAT 1345Ile Val Tyr Lys Phe Ile Ser Ser Lys Leu Val Phe Phe Tyr Asp Asn
430 435 440AAG CAA CGC CTT TTT TTA AAC AGC GCG AAC ATG TTT GTT TTA AAA GAA 1393Lys Gln Arg Leu Phe Leu Asn Ser Ala Asn Met Phe Val Leu Lys Glu445 450 455 460AAT TTC CCT ATC AAC GCT CAT GCA TTA AAA GAA TTG TTA AAC AGC GAT 1441Asn Phe Pro Ile Asn Ala His Ala Leu Lys Glu Leu Leu Asn Ser Asp
465 470 475TTA ATG CAA TTC ATT TTT GAA TCG CTT TTT AAA ACG CAT AAA ATC TTA 1489 Leu Met Gln Phe Ile Phe Glu Ser Leu Phe Lys Thr His Lys Ile Leu
480 485 490AGA AAA GAT TTG GAA TGT TTG CCC CTA TTT GTG CAA TTT ATT AAC GAT 1537Arg Lys Asp Leu Glu Cys Leu Pro Leu Phe Val Gln Phe Ile Asn Asp
495 500 505AAT TTT GAT GAA AAA TTT TAT TTA AAA AAT TTA GGG ATA GAA AAA AAA 1585Asn Phe Asp Glu Lys Phe Tyr Leu Lys Asn Leu Gly Ile Glu Lys Lys
510 515 520GAC CCT AAA CAT TTC ACC ATC AGG AAA AAT CAT GCA TGT TGC TTG TCT 1633Asp Pro Lys His Phe Thr Ile Arg Lys Asn His Ala Cys Cys Leu Ser525 530 535 540TTT GGC TTT AGG GGA TAATCTCATC ACGCTTAGCC TTTTAAAAGA AATCGCTTTC A 1689Phe Gly Phe Arg Gly
545AACAGCAA 1697 (2) sequence 1334 data: (i) sequence characteristics: length (A): 545 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1334: met Pro Ser Asn Ala Leu Leu Ile Glu Glu Ile Thr His Leu Ile Asn 151015 Val Ser His Ser Ser Val His Asn Trp Ile Lys Thr Asn Leu Leu Glu
20 25 30Lys Leu Glu Ile Asp His Lys Ile Tyr Val Lys Thr Ser Ser Phe Leu
35 40 45Asp Phe Cys Arg Asn His Leu Gly Lys Asn Lys Leu Asn Lys Tyr Ala
50 55 60Asn Lys Ser Leu Lys Gly Val His Asn His Gln Glu Leu Ile Leu Lys65 70 75 80Tyr Leu Glu Ile Leu Glu Asn Ser Ser Asp Leu Glu Lys Leu Gly Ser
85 90 95Tyr Tyr Glu Glu Glu Leu Ser Asn Ala Thr Arg Asn Leu Glu Gly Ile
100 105 110Tyr Tyr Thr Pro Asn Arg Ile Val Glu Gln Leu Phe Thr Leu Pro Lys
115 120 125Asp Phe Asp Val Ser Gln Ala Ile Phe Cys Asp Pro Ala Val Gly Ser
130 135 140Gly Asn Phe Ile Met His Ala Leu Lys Leu Gly Phe Lys Val Glu Asn145 150 155 160Ile Tyr Gly Tyr Asp Thr Asp Ala Phe Ala Val Ala Leu Thr Lys Lys
165 170 175Arg Ile Lys Glu Arg Tyr His Leu Asp Cys Leu Asn Ile Val Gln Lys
180 185 190Asp Phe Leu Asn Leu Lys His Thr Pro Gln Phe Asp Cys Ile Phe Thr
195 200 205Asn Pro Pro Trp Gly Lys Lys Tyr Asn Gln Asn Gln Lys Glu Asn Phe
210 215 220Lys Gln Gln Phe Asn Leu Ser Gln Ser Leu Asp Ser Ala Ser Leu Phe225 230 235 240Phe Ile Ala Ser Leu Asn Cys Leu Lys Glu Asn Ala His Leu Gly Leu
245 250 255Leu Leu Pro Glu Ser Cys Leu Asn Ile Asp Ala Phe Lys Lys Met Arg
260 265 270Glu Met Ala Leu Lys Phe His Ile Arg Ser Leu Ile Asp Phe Asp Lys
275 280 285Pro Phe Lys Asn Leu Met Thr Lys Ala Val Gly Leu Ala Leu Lys Lys
290 295 300Thr Pro Asn Lys Asp Gln Lys Ile Ser Cys Phe Tyr Gln Asn Ser Lys305310 315 320Phe Lys Arg Ser Pro Ser Ser Phe Phe Asn Asn Pro Lys Lys Ile Phe
325 330 335Asn Ile His Cys Ser Ser Lys Glu Asn Lys Ile Leu Asp His Leu Phe
340 345 350Ser Leu Pro His Met Thr Leu Lys Asn Asn Ala His Phe Ala Leu Gly
355 360 365Ile Val Thr Gly Asn Asn Lys Glu Lys Leu His Pro Lys Gln Glu Lys
370 375 380Asn Thr Ile Pro Ile Phe Arg Gly Ser Asp Ile Leu Lys Asp Gly Leu385 390 395 400Lys Ala Pro Ser Gln Phe Ile Asn Ala Gly Leu Lys Asp Cys Gln Gln
405 410 415Val Ala Pro Leu Ser Leu Tyr Gln Ala Arg Glu Lys Ile Val Tyr Lys
420 425 430Phe Ile Ser Ser Lys Leu Val Phe Phe Tyr Asp Asn Lys Gln Arg Leu
435 440 445Phe Leu Asn Ser Ala Asn Met Phe Val Leu Lys Glu Asn Phe Pro Ile
450 455 460Asn Ala His Ala Leu Lys Glu Leu Leu Asn Ser Asp Leu Met Gln Phe465 470 475 480Ile Phe Glu Ser Leu Phe Lys Thr His Lys Ile Leu Arg Lys Asp Leu
485 490 495Glu Cys Leu Pro Leu Phe Val Gln Phe Ile Asn Asp Asn Phe Asp Glu
500 505 510Lys Phe Tyr Leu Lys Asn Leu Gly Ile Glu Lys Lys Asp Pro Lys His
515 520 525Phe Thr Ile Arg Lys Asn His Ala Cys Cys Leu Ser Phe Gly Phe Arg
530535540 Gly545 (2) sequence 1335 data: (i) sequence characteristics: length (A): 1884bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1842 (D) other information: (xi) Description of the sequence: sequence 1335: TATTGTGTTA TACTTCTAAT TTCAATTTTG CTTGTTAGGA CATTT ATG AAA AAT ATT 57
Met Lys Asn Ile
1AGA AAT ATC GCT GTA ATC GCG CAT GTT GAT CAT GGG AAA ACC ACT CTA 105Arg Asn Ile Ala Val Ile Ala His Val Asp His Gly Lys Thr Thr Leu 5 10 15 20GTA GAT GGC TTA CTT TCT CAA TCT GGC ACA TTT AGT GAG AGG GAA AAA 153Val Asp Gly Leu Leu Ser Gln Ser Gly Thr Phe Ser Glu Arg Glu Lys
25 30 35GTG GAT GAA AGG GTG ATG GAT AGC AAT GAT TTG GAA AGA GAA AGA GGG 201Val Asp Glu Arg Val Met Asp Ser Asn Asp Leu Glu Arg Glu Arg Gly
40 45 50ATT ACT ATC CTG TCT AAA AAC ACC GCT ATT TAT TAC AAA GAC ACT AAA 249Ile Thr Ile Leu Ser Lys Asn Thr Ala Ile Tyr Tyr Lys Asp Thr Lys
55 60 65ATC AAT ATC ATT GAC ACT CCC GGG CAT GCT GAT TTT GGG GGC GAA GTG 297Ile Asn Ile Ile Asp Thr Pro Gly His Ala Asp Phe Gly Gly Glu Val
70 75 80GAG CGC GTT TTA AAA ATG GTG GAT GGG GTG TTG CTT TTA GTG GAC GCT 345Glu Arg Val Leu Lys Met Val Asp Gly Val Leu Leu Leu Val Asp Ala85 90 95 100CAA GAA GGG GTC ATG CCT CAA ACT AAA TTC GTG GTT AAA AAG GCT TTG 393Gln Glu Gly Val Met Pro Gln Thr Lys Phe Val Val Lys Lys Ala Leu
105 110 115AGT TTT GGG ATT TGC CCT ATT GTG GTG GTG AAT AAA ATT GAT AAG CCT 441Ser Phe Gly Ile Cys Pro Ile Val Val Val Asn Lys Ile Asp Lys Pro
120 125 130GCC GCT GAA CCG GAC AGA GTG GTG GAT GAA GTT TTT GAC TTG TTC GTA 489Ala Ala Glu Pro Asp Arg Val Val Asp Glu Val Phe Asp Leu Phe Val
135 140 145GCC ATG GGG GCT AGC GAT AAG CAA TTG GAT TTC CCT GTG GTG TAT GCC 537Ala Met Gly Ala Ser Asp Lys Gln Leu Asp Phe Pro Val Val Tyr Ala
150 155 160GCC GCA CGA GAT GGC TAT GCG ATG AAA AGT TTA GAC GAT GAA AAG AAA 585Ala Ala Arg Asp Gly Tyr Ala Met Lys Ser Leu Asp Asp Glu Lys Lys165 170 175 180AAT TTA GAG CCT TTG TTT GAA ACG ATT TTA GAG CAT GTG CCA AGC CCT 633Asn Leu Glu Pro Leu Phe Glu Thr Ile Leu Glu His Val Pro Ser Pro
185 190 195AGC GGG AGC GTT GAT GAG CCT TTG CAA ATG CAA ATT TTC ACG CTT GAT 681Ser Gly Ser Val Asp Glu Pro Leu Gln Met Gln Ile Phe Thr Leu Asp
200 205 210TAT GAC AAT TAT GTG GGC AAA ATC GGT ATC GCT AGG GTG TTT AAT GGC 729Tyr Asp Asn Tyr Val Gly Lys Ile Gly Ile Ala Arg Val Phe Asn Gly
215 220 225TCG GTT AAA AAG AAT GAA AGC GTG CTG TTG ATG AAA AGC GAT GGG AGT 777Ser Val Lys Lys Asn Glu Ser Val Leu Leu Met Lys Ser Asp Gly Ser
230 235 240AAA GAA AAT GGC CGT ATC ACT AAG CTT ATA GGT TTT TTA GGG CTG GCT 825Lys Glu Asn Gly Arg Ile Thr Lys Leu Ile Gly Phe Leu Gly Leu Ala245 250255 260AGG ACT GAG ATT GAA AAC GCT TAT GCG GGC GAT ATT GTA GCG ATT GCC 873Arg Thr Glu Ile Glu Asn Ala Tyr Ala Gly Asp Ile Val Ala Ile Ala
265 270 275GGG TTT AAT GCA ATG GAT GTG GGC GAT AGC GTC GTT GAT CCT GCT AAC 921Gly Phe Asn Ala Met Asp Val Gly Asp Ser Val Val Asp Pro Ala Asn
280 285 290CCC ATG CCT TTA GAT CCC ATG CAT TTA GAA GAG CCT ACG ATG AGC GTG 969Pro Met Pro Leu Asp Pro Met His Leu Glu Glu Pro Thr Met Ser Val
295 300 305TAT TTT GCT GTC AAT GAT TCA CCC TTA GCC GGG TTA GAA GGA AAG CAT 1017Tyr Phe Ala Val Asn Asp Ser Pro Leu Ala Gly Leu Glu Gly Lys His
310 315 320GTT ACT GCT AAT AAA TTG AAA GAC AGG CTC TTA AAA GAA ATG CAA ACC 1065Val Thr Ala Asn Lys Leu Lys Asp Arg Leu Leu Lys Glu Met Gln Thr325 330 335 340AAT ATC GCT ATG AAA TGC GAA GAA ATG GGC GAG GGC AAG TTT AAA GTG 1113Asn Ile Ala Met Lys Cys Glu Glu Met Gly Glu Gly Lys Phe Lys Val
345 350 355AGT GGG CGT GGG GAA TTG CAA ATC ACT ATT TTA GCT GAA AAC TTG CGC 1161Ser Gly Arg Gly Glu Leu Gln Ile Thr Ile Leu Ala Glu Asn Leu Arg
360 365 370CGT GAA GGG TTT GAA TTT AGC ATT TCA CGC CCT GAA GTC ATC ATT AAA 1209Arg Glu Gly Phe Glu Phe Ser Ile Ser Arg Pro Glu Val Ile Ile Lys
375 380 385GAA GAA AAT GGC GTT AAA TGC GAG CCT TTT GAG CAT TTA GTG ATT GAC 1257Glu Glu Asn Gly Val Lys Cys Glu Pro Phe Glu His Leu Val Ile Asp
390 395 400ACG CCC CAA GAT TTT AGT GGG GCT ATC ATT GAG AGA TTG GGC AAA AGA 1305Thr Pro Gln Asp Phe Ser Gly Ala Ile Ile Glu Arg Leu Gly Lys Arg405 410 415 420AAA GCT GAG ATG AAA GCG ATG AAT CCC ATG AGT GAT GGC TAT ACA AGA 1353Lys Ala Glu Met Lys Ala Met Asn Pro Met Ser Asp Gly Tyr Thr Arg
425 430 435TTA GAA TTT GAA ATT CCT GCA AGA GGG CTT ATC GGT TAT AGG AGC GAG 1401Leu Glu Phe Glu Ile Pro Ala Arg Gly Leu Ile Gly Tyr Arg Ser Glu
440 445 450TTT TTA ACC GAC ACC AAG GGC GAA GGC GTG ATG AAT CAT AGC TTT TTA 1449Phe Leu Thr Asp Thr Lys Gly Glu Gly Val Met Asn His Ser Phe Leu
455 460 465GAA TTC CGC CCT TTC AGC GGG AGC GTG GAA TCG CGC AAA AAT GGG GCG 1497Glu Phe Arg Pro Phe Ser Gly Ser Val Glu Ser Arg Lys Asn Gly Ala
470 475 480CTA ATC AGC ATG GAA AAT GGC GAA GCG ACC GCT TTT TCC CTT TTC AAT 1545Leu Ile Ser Met Glu Asn Gly Glu Ala Thr Ala Phe Ser Leu Phe Asn485 490 495 500ATC CAA GAA AGA GGC ACG CTT TTT ATC AAC CCC CAA ACG AAG GTT TAT 1593Ile Gln Glu Arg Gly Thr Leu Phe Ile Asn Pro Gln Thr Lys Val Tyr
505 510 515GTG GGC ATG GTC ATT GGC GAG CAC AGC CGG GAT AAT GAT TTA GAT GTC 1641Val Gly Met Val Ile Gly Glu His Ser Arg Asp Asn Asp Leu Asp Val
520 525 530AAT CCT ATT AAA TCC AAG CAT TTA ACC AAC ATG AGA GCG AGC GGG AGC 1689Asn Pro Ile Lys Ser Lys His Leu Thr Asn Met Arg Ala Ser Gly Ser
535 540 545GAT GAT GCG ATC AAA CTC ACC CCG CCT AGG ACT ATG GTG TTA GAA AGA 1737Asp Asp Ala Ile Lys Leu Thr Pro Pro Arg Thr Met Val Leu Glu Arg
550 555 560GCG TTA GAA TGG ATT GAA GAA GAT GAG ATT TTG GAA GTT ACC CCC TTG 1785Ala Leu Glu Trp Ile Glu Glu Asp Glu Ile Leu Glu Val Thr Pro Leu565 570 575 580AAT TTA AGG ATC AGG AAA AAG ATT TTA GAC CCT AAC ATG AGG AAA AGG 1833Asn Leu Arg Ile Arg Lys Lys Ile Leu Asp Pro Asn Met Arg Lys Arg
585590595 GCG AAA AAA TAAATAGAAT TTTTTGGAAT GCATGCCAAT TTATTCAACC AA 1884Ala Lys Lys (2) sequence 1336 data: (i) sequence characteristics: length (A): 599 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1336: met Lys Asn Ile Arg Asn Ile Ala Val Ile Ala His Val Asp His Gly 151015 Lys Thr Thr Leu Val Asp Gly Leu Leu Ser Gln Ser Gly Thr Phe Ser
20 25 30Glu Arg Glu Lys Val Asp Glu Arg Val Met Asp Ser Asn Asp Leu Glu
35 40 45Arg Glu Arg Gly Ile Thr Ile Leu Ser Lys Asn Thr Ala Ile Tyr Tyr
50 55 60Lys Asp Thr Lys Ile Asn Ile Ile Asp Thr Pro Gly His Ala Asp Phe65 70 75 80Gly Gly Glu Val Glu Arg Val Leu Lys Met Val Asp Gly Val Leu Leu
85 90 95Leu Val Asp Ala Gln Glu Gly Val Met Pro Gln Thr Lys Phe Val Val
100 105 110Lys Lys Ala Leu Ser Phe Gly Ile Cys Pro Ile Val Val Val Asn Lys
115 120 125Ile Asp Lys Pro Ala Ala Glu Pro Asp Arg Val Val Asp Glu Val Phe
130 135 140Asp Leu Phe Val Ala Met Gly Ala Ser Asp Lys Gln Leu Asp Phe Pro145 150 155 160Val Val Tyr Ala Ala Ala Arg Asp Gly Tyr Ala Met Lys Ser Leu Asp
165 170 175Asp Glu Lys Lys Asn Leu Glu Pro Leu Phe Glu Thr Ile Leu Glu His
180 185 190Val Pro Ser Pro Ser Gly Ser Val Asp Glu Pro Leu Gln Met Gln Ile
195 200 205Phe Thr Leu Asp Tyr Asp Asn Tyr Val Gly Lys Ile Gly Ile Ala Arg
210 215 220Val Phe Asn Gly Ser Val Lys Lys Asn Glu Ser Val Leu Leu Met Lys225 230 235 240Ser Asp Gly Ser Lys Glu Asn Gly Arg Ile Thr Lys Leu Ile Gly Phe
245 250 255Leu Gly Leu Ala Arg Thr Glu Ile Glu Asn Ala Tyr Ala Gly Asp Ile
260 265 270Val Ala Ile Ala Gly Phe Asn Ala Met Asp Val Gly Asp Ser Val Val
275 280 285Asp Pro Ala Asn Pro Met Pro Leu Asp Pro Met His Leu Glu Glu Pro
290 295 300Thr Met Ser Val Tyr Phe Ala Val Asn Asp Ser Pro Leu Ala Gly Leu305 310 315 320Glu Gly Lys His Val Thr Ala Asn Lys Leu Lys Asp Arg Leu Leu Lys
325 330 335Glu Met Gln Thr Asn Ile Ala Met Lys Cys Glu Glu Met Gly Glu Gly
340 345 350Lys Phe Lys Val Ser Gly Arg Gly Glu Leu Gln Ile Thr Ile Leu Ala
355 360 365Glu Asn Leu Arg Arg Glu Gly Phe Glu Phe Ser Ile Ser Arg Pro Glu
370 375 380Val Ile Ile Lys Glu Glu Asn Gly Val Lys Cys Glu Pro Phe Glu His385 390 395 400Leu Val Ile Asp Thr Pro Gln Asp Phe Ser Gly Ala Ile Ile Glu Arg
405 410 415Leu Gly Lys Arg Lys Ala Glu Met Lys Ala Met Asn Pro Met Ser Asp
420 425 430Gly Tyr Thr Arg Leu Glu Phe Glu Ile Pro Ala Arg Gly Leu Ile Gly
435 440 445Tyr Arg Ser Glu Phe Leu Thr Asp Thr Lys Gly Glu Gly Val Met Asn
450 455 460His Ser Phe Leu Glu Phe Arg Pro Phe Ser Gly Ser Val Glu Ser Arg465 470 475 480Lys Asn Gly Ala Leu Ile Ser Met Glu Asn Gly Glu Ala Thr Ala Phe
485 490 495Ser Leu Phe Asn Ile Gln Glu Arg Gly Thr Leu Phe Ile Asn Pro Gln
500 505 510Thr Lys Val Tyr Val Gly Met Val Ile Gly Glu His Ser Arg Asp Asn
515 520 525Asp Leu Asp Val Asn Pro Ile Lys Ser Lys His Leu Thr Asn Met Arg
530 535 540Ala Ser Gly Ser Asp Asp Ala Ile Lys Leu Thr Pro Pro Arg Thr Met545 550 555 560Val Leu Glu Arg Ala Leu Glu Trp Ile Glu Glu Asp Glu Ile Leu Glu
565 570 575Val Thr Pro Leu Asn Leu Arg Ile Arg Lys Lys Ile Leu Asp Pro Asn
580 585590Met Arg Lys Arg Ala Lys Lys
595 (2) sequence 1337: (i) sequence characteristics: length (A): 880bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 839 (D) other information: (xi) Description of the sequence: sequence 1337: TTCTACTAGG CGGACCACCA TGCCAGAGCT ATTCTACCCT TGGCAAAAGA AAA ATG 56
Met
1GAT GAA AAA GCG AAT CTG TTT AAA GAA TAT TTG CGG CTT TTA GAT TTA 104Asp Glu Lys Ala Asn Leu Phe Lys Glu Tyr Leu Arg Leu Leu Asp Leu
5 10 15GTA AAA CCA AAA ATA TTT GTT TTT GAA AAT GTG GTG GGT TTA ATG TCT 152Val Lys Pro Lys Ile Phe Val Phe Glu Asn Val Val Gly Leu Met Ser
20 25 30ATG CAA AAA GGG CAA TTA TTC AAA CAA ATT TGT AAC GCT TTT AAA GAG 200Met Gln Lys Gly Gln Leu Phe Lys Gln Ile Cys Asn Ala Phe Lys Glu
35 40 45AGA GAT TAT ATT TTA GAG CAT GCC ATT TTG AAC GCC CTA GAT TAT GGT 248Arg Asp Tyr Ile Leu Glu His Ala Ile Leu Asn Ala Leu Asp Tyr Gly50 55 60 65GTG CCT CAA ATG AGA GAA CGA GTG ATT TTA GTG GGC GTG CTT AAA AGC 296Val Pro Gln Met Arg Glu Arg Val Ile Leu Val Gly Val Leu Lys Ser
70 75 80TTT AAA CAA AAA TTT TAC TTC CCT AAA CCC ATA AAA ACG CAT TTT TCT 344Phe Lys Gln Lys Phe Tyr Phe Pro Lys Pro Ile Lys Thr His Phe Ser
85 90 95CTG AAA GAC GCT TTA GGG GAT TTA CCA CCC ATT CAA AGC GGT GAA AAT 392Leu LysAsp Ala Leu Gly Asp Leu Pro Pro Ile Gln Ser Gly Glu Asn
100 105 110GGT GAT GCT TTA GGT TAT CTT AAA AAT GCG GAT AAT GTT TTT TTG GAA 440Gly Asp Ala Leu Gly Tyr Leu Lys Asn Ala Asp Asn Val Phe Leu Glu
115 120 125TTT GTG CGA AAT TCT AAA GAA TTA AGC GAA CAT AGC AGT CCT AAA AAC 488Phe Val Arg Asn Ser Lys Glu Leu Ser Glu His Ser Ser Pro Lys Asn130 135 140 145AAT GAA AAA CTG ATA AAA ATC ATG CAA ACG CTA AAA GAC GGA CAG AGT 536Asn Glu Lys Leu Ile Lys Ile Met Gln Thr Leu Lys Asp Gly Gln Ser
150 155 160AAA GAT GAT TTG CCA GAA AGT CTG CGT CCC AAA AGT GGT TAT ATT AAT 584Lys Asp Asp Leu Pro Glu Ser Leu Arg Pro Lys Ser Gly Tyr Ile Asn
165 170 175ACC TAT GCC AAA ATG TGG TGG GAA AAA CCA GCC CCC ACC ATT ACA AGA 632Thr Tyr Ala Lys Met Trp Trp Glu Lys Pro Ala Pro Thr Ile Thr Arg
180 185 190AAT TTT TCT ACC CCA AGC AGT TCT AGG TGT ATC CAT CCA AGA GAC TCT 680Asn Phe Ser Thr Pro Ser Ser Ser Arg Cys Ile His Pro Arg Asp Ser
195 200 205AGA GCG TTA AGC ATT AGA GAG GGG GCA AGA TTG CAA AGC TTT CCT GAT 728Arg Ala Leu Ser Ile Arg Glu Gly Ala Arg Leu Gln Ser Phe Pro Asp210 215 220 225AAT TAT AAA TTC TGT GGG AGT GGT AGC GCT AAA AGA TTG CAA ATT GGC 776Asn Tyr Lys Phe Cys Gly Ser Gly Ser Ala Lys Arg Leu Gln Ile Gly
230 235 240AAT GCC GTG CCG CCT TTA TTG AGT GTA GCG CTC GCG CAG GCG GTC TTT 824Asn Ala Val Pro Pro Leu Leu Ser Val Ala Leu Ala Gln Ala Val Phe
245 250 255GAC TTT TTA AAG GGG TAAGATGTTT AACAATAATG ACTTTAAGGA TTACAGAAAA T 880Asp Phe Leu Lys Gly
260
880 (2) data in SEQ ID 1338: (i) sequence characteristics: length (A): 262 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1338: met Asp Glu Lys Ala Asn Leu Phe Lys Glu Tyr Leu Arg Leu Leu Asp 151015 Leu Val Lys Pro Lys Ile Phe Val Phe Glu Asn Val Val Gly Leu Met
20 25 30Ser Met Gln Lys Gly Gln Leu Phe Lys Gln Ile Cys Asn Ala Phe Lys
35 40 45Glu Arg Asp Tyr Ile Leu Glu His Ala Ile Leu Asn Ala Leu Asp Tyr
50 55 60Gly Val Pro Gln Met Arg Glu Arg Val Ile Leu Val Gly Val Leu Lys65 70 75 80Ser Phe Lys Gln Lys Phe Tyr Phe Pro Lys Pro Ile Lys Thr His Phe
85 90 95Ser Leu Lys Asp Ala Leu Gly Asp Leu Pro Pro Ile Gln Ser Gly Glu
100 105 110Asn Gly Asp Ala Leu Gly Tyr Leu Lys Asn Ala Asp Asn Val Phe Leu
115 120 125Glu Phe Val Arg Asn Ser Lys Glu Leu Ser Glu His Ser Ser Pro Lys
130 135 140Asn Asn Glu Lys Leu Ile Lys Ile Met Gln Thr Leu Lys Asp Gly Gln145 150 155 160Ser Lys Asp Asp Leu Pro Glu Ser Leu Arg Pro Lys Ser Gly Tyr Ile
165 170 175Asn Thr Tyr Ala Lys Met Trp Trp Glu Lys Pro Ala Pro Thr Ile Thr
180 185 190Arg Asn Phe Ser Thr Pro Ser Ser Ser Arg Cys Ile His Pro Arg Asp
195 200 205Ser Arg Ala Leu Ser Ile Arg Glu Gly Ala Arg Leu Gln Ser Phe Pro
210 215 220Asp Asn Tyr Lys Phe Cys Gly Ser Gly Ser Ala Lys Arg Leu Gln Ile225 230 235 240Gly Asn Ala Val Pro Pro Leu Leu Ser Val Ala Leu Ala Gln Ala Val
245 250 255Phe Asp Phe Leu Lys Gly
260(2) sequence 1339 data: (i) sequence characteristics: length (A): 1376bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1338 (D) other information: (xi) Description of the sequence: sequence 1339: TGGTAGTTAA GA ATG GGT AAT CAT TTT TCT AAA TTA GGA TTT GTT TTA GCC 51
Met Gly Asn His Phe Ser Lys Leu Gly Phe Val Leu Ala
1 5 10GCA TTA GGA AGC GCG ATA GGT TTA GGG CAT ATC TGG CGT TTC CCC TAC 99Ala Leu Gly Ser Ala Ile Gly Leu Gly His Ile Trp Arg Phe Pro Tyr
15 20 25ATG ACT GGG GTG AGT GGT GGG GGT GCT TTT GTT TTA TTG TTT TTA TTT 147Met Thr Gly Val Ser Gly Gly Gly Ala Phe Val Leu Leu Phe Leu Phe30 35 40 45TTA TCT TTA AGC GTT GGC GCG GCG ATG TTT ATC GCT GAA ATG CTA TTA 195Leu Ser Leu Ser Val Gly Ala Ala Met Phe Ile Ala Glu Met Leu Leu
50 55 60GGA CAA AGC ACT CAA AAA AAT GTA ACA GAA GCT TTT AAA GAG CTT GAC243Gly Gln Ser Thr Gln Lys Asn Val Thr Glu Ala Phe Lys Glu Leu Asp
65 70 75ATT AAC CCC AAA AAA CGC TGG AAA TAC GCA GGG CTT TTG CTT GTT TCT 291Ile Asn Pro Lys Lys Arg Trp Lys Tyr Ala Gly Leu Leu Leu Val Ser
80 85 90GGG CCA TTA ATA CTG ACT TTT TAC GGC ACG ATT TTA GGT TGG GTG CTT 339Gly Pro Leu Ile Leu Thr Phe Tyr Gly Thr Ile Leu Gly Trp Val Leu
95 100 105TAT TAT TTG GTG AGT GTT AGT TTT AAT TTG CCT AAC AAT ATC CAA GAA 387Tyr Tyr Leu Val Ser Val Ser Phe Asn Leu Pro Asn Asn Ile Gln Glu110 115 120 125TCT GAA CAA ATT TTT ACT CAA ACT TTG CAG TCT ATA GGG CTA CAA TCC 435Ser Glu Gln Ile Phe Thr Gln Thr Leu Gln Ser Ile Gly Leu Gln Ser
130 135 140ATA GGG CTT TTT AGC GTT TTA TTG ATA ACC GGA TGG ATT GTT TCT AGG 483Ile Gly Leu Phe Ser Val Leu Leu Ile Thr Gly Trp Ile Val Ser Arg
145 150 155GGG ATT AAA GAA GGC ATT GAA AAG CTC AAT TTG GTT TTA ATG CCC TTA 531Gly Ile Lys Glu Gly Ile Glu Lys Leu Asn Leu Val Leu Met Pro Leu
160 165 170CTC TTT GCT ACT TTT TTT GGT TTG CTT TTC TAT GCG ATG AGC ATG GAT 579Leu Phe Ala Thr Phe Phe Gly Leu Leu Phe Tyr Ala Met Ser Met Asp
175 180 185TCT TTT TCT AAA GCT TTT CAT TTC ATG TTT GAT TTC AAA CCA AAA GAT 627Ser Phe Ser Lys Ala Phe His Phe Met Phe Asp Phe Lys Pro Lys Asp190 195 200 205TTG ACC TCT CAA GTG TTC ACT TAT TCC TTG GGG CAG GTT TTC TTT TCC 675Leu Thr Ser Gln Val Phe Thr Tyr Ser Leu Gly Gln Val Phe Phe Ser
210 215 220TTA AGC ATC GGT TTA GGG ATC AAT ATC ACT TAC GCT GCG GTT ACG GAT 723Leu Ser Ile Gly Leu Gly Ile Asn Ile Thr Tyr Ala Ala Val Thr Asp
225 230 235AAA ACG CAG AAT TTG CTT AAA AGC ACT ATT TGG GTG GTT TTA TCA GGA 771Lys Thr Gln Asn Leu Leu Lys Ser Thr Ile Trp Val Val Leu Ser Gly
240 245 250ATT CTA ATT TCT CTT GTG GCA GGA CTT ATG ATT TTC ACT TTT GTG TTT 819Ile Leu Ile Ser Leu Val Ala Gly Leu Met Ile Phe Thr Phe Val Phe
255 260 265GAA TAT GGG GCG AAT GTC TCA CAA GGC ACA GGG TTA ATC TTC ACT TCT 867Glu Tyr Gly Ala Asn Val Ser Gln Gly Thr Gly Leu Ile Phe Thr Ser270 275 280 285TTA CCG GTG GTT TTT GGC CAA ATG GGA GCG ATA GGC ATT CTT GTT TCG 915Leu Pro Val Val Phe Gly Gln Met Gly Ala Ile Gly Ile Leu Val Ser
290 295 300ATT CTT TTC TTG CTC GCG CTC GCT TTT GCT GGC ATC ACT TCT ACG GTG 963Ile Leu Phe Leu Leu Ala Leu Ala Phe Ala Gly Ile Thr Ser Thr Val
305 310 315GCT TTA TTG GAG CCA AGC GTG ATG TAT CTT ACC GAA AGG TAT CAA TAC 1011Ala Leu Leu Glu Pro Ser Val Met Tyr Leu Thr Glu Arg Tyr Gln Tyr
320 325 330TCT CGT TTT AAG GTT ACT TGG GGT CTT GTA GCA CTA ATT TTT GTG GTA 1059Ser Arg Phe Lys Val Thr Trp Gly Leu Val Ala Leu Ile Phe Val Val
335 340 345GGC GTG GTG TTG ATT TTC TCG CTC CAT AAG GAT TAT AAA GAT TAT CTC 1107Gly Val Val Leu Ile Phe Ser Leu His Lys Asp Tyr Lys Asp Tyr Leu350 355 360 365ACT TTC TTT GAA AAA AGT CTT TTT GAT TGG TTG GAT TTT GCA TCA AGC 1155Thr Phe Phe Glu Lys Ser Leu Phe Asp Trp Leu Asp Phe Ala Ser Ser
370 375 380ACC ATT ATC ATG CCT TTA GGC GGG ATG GCA ACC TTT ATT TTT ATG GGT 1203Thr Ile Ile Met Pro Leu Gly Gly Met Ala Thr Phe Ile Phe Met Gly
385 390 395TGG GTT TTG AAA AAA GAA AAA TTG CGT CTT TTG AGC GTG CAC TTT TTA 1251Trp Val Leu Lys Lys Glu Lys Leu Arg Leu Leu Ser Val His Phe Leu
400 405 410GGC CCT AAA TTG TTT GCA ACT TGG TAT TTC TTG CTT AAA TAT ATC ACC 1299Gly Pro Lys Leu Phe Ala Thr Trp Tyr Phe Leu Leu Lys Tyr Ile Thr
415420425 CCT TTA ATT GTG TTT TCC ATT TGG TTG AGC AAG ATT TAT TAAAATATTT GG 1350Pro Leu Ile Val Phe Ser Ile Trp Leu Ser Lys Ile Tyr 430435440 CATGGAAAA TTTTCTAAAT TAGGCT 1376 (2) sequence 1340 data: (i) sequence characteristics: length (A): 442 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1340: met Gly Asn His Phe Ser Lys Leu Gly Phe Val Leu Ala Ala Leu Gly 151015 Ser Ala Ile Gly Leu Gly His Ile Trp Arg Phe Pro Tyr Met Thr Gly
20 25 30Val Ser Gly Gly Gly Ala Phe Val Leu Leu Phe Leu Phe Leu Ser Leu
35 40 45Ser Val Gly Ala Ala Met Phe Ile Ala Glu Met Leu Leu Gly Gln Ser
50 55 60Thr Gln Lys Asn Val Thr Glu Ala Phe Lys Glu Leu Asp Ile Asn Pro65 70 75 80Lys Lys Arg Trp Lys Tyr Ala Gly Leu Leu Leu Val Ser Gly Pro Leu
85 90 95Ile Leu Thr Phe Tyr Gly Thr Ile Leu Gly Trp Val Leu Tyr Tyr Leu
100 105 110Val Ser Val Ser Phe Asn Leu Pro Asn Asn Ile Gln Glu Ser Glu Gln
115 120 125Ile Phe Thr Gln Thr Leu Gln Ser Ile Gly Leu Gln Ser Ile Gly Leu
130 135 140Phe Ser Val Leu Leu Ile Thr Gly Trp Ile Val Ser Arg Gly Ile Lys145 150 155 160Glu Gly Ile Glu Lys Leu Asn Leu Val Leu Met Pro Leu Leu Phe Ala
165 170 175Thr Phe Phe Gly Leu Leu Phe Tyr Ala Met Ser Met Asp Ser Phe Ser
180 185 190Lys Ala Phe His Phe Met Phe Asp Phe Lys Pro Lys Asp Leu Thr Ser
195 200 205Gln Val Phe Thr Tyr Ser Leu Gly Gln Val Phe Phe Ser Leu Ser Ile
210 215 220Gly Leu Gly Ile Asn Ile Thr Tyr Ala Ala Val Thr Asp Lys Thr Gln225 230 235 240Asn Leu Leu Lys Ser Thr Ile Trp Val Val Leu Ser Gly Ile Leu Ile
245 250 255Ser Leu Val Ala Gly Leu Met Ile Phe Thr Phe Val Phe Glu Tyr Gly
260 265 270Ala Asn Val Ser Gln Gly Thr Gly Leu Ile Phe Thr Ser Leu Pro Val
275 280 285Val Phe Gly Gln Met Gly Ala Ile Gly Ile Leu Val Ser Ile Leu Phe
290 295 300Leu Leu Ala Leu Ala Phe Ala Gly Ile Thr Ser Thr Val Ala Leu Leu305 310 315 320Glu Pro Ser Val Met Tyr Leu Thr Glu ArgTyr Gln Tyr Ser Arg Phe
325 330 335Lys Val Thr Trp Gly Leu Val Ala Leu Ile Phe Val Val Gly Val Val
340 345 350Leu Ile Phe Ser Leu His Lys Asp Tyr Lys Asp Tyr Leu Thr Phe Phe
355 360 365Glu Lys Ser Leu Phe Asp Trp Leu Asp Phe Ala Ser Ser Thr Ile Ile
370 375 380Met Pro Leu Gly Gly Met Ala Thr Phe Ile Phe Met Gly Trp Val Leu385 390 395 400Lys Lys Glu Lys Leu Arg Leu Leu Ser Val His Phe Leu Gly Pro Lys
405 410 415Leu Phe Ala Thr Trp Tyr Phe Leu Leu Lys Tyr Ile Thr Pro Leu Ile
420 425 430Val Phe Ser Ile Trp Leu Ser Lys Ile Tyr
435440 (2) data of SEQ ID No. 1341: (i) sequence characteristics: length (A): 1120bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1081 (D) other information: (xi) Description of the sequence: sequence 1341: GAAATAAGGA TGCTTG ATG AAA AGC ATT TTG CTC TTT ATG ATT TTT GTA GTT 52
Met Lys Ser Ile Leu Leu Phe Met Ile Phe Val Val
1 5 10TGT CAG TTA GAA GGC AAA AAA TTT TCA CAA GAT AAT TTT AAG GTG GAT 100Cys Gln Leu Glu Gly Lys Lys Phe Ser Gln Asp Asn Phe Lys Val Asp
15 20 25TAT AAC TAC TAT TTG CGC AAA CAG GAT TTG CAC ATC ATT AAA ACG CAA 148Tyr Asn Tyr Tyr Leu Arg Lys Gln Asp Leu His Ile Ile Lys ThrGln
30 35 40AAC GAT TTG TCC AAT TCT TGG TAT CTC CCT CCA CAA AAA GCC CCC AAA 196Asn Asp Leu Ser Asn Ser Trp Tyr Leu Pro Pro Gln Lys Ala Pro Lys45 50 55 60GAA CAT TCT TGG GTG GAT TTT GCT AAA AAA TAT TTA AAC ATG ATG GAT 244Glu His Ser Trp Val Asp Phe Ala Lys Lys Tyr Leu Asn Met Met Asp
65 70 75TAT CTA GGC ACT TAT TTT CTG CCT TTT TAT CAT AGT TTC ACC CCC ATT 292Tyr Leu Gly Thr Tyr Phe Leu Pro Phe Tyr His Ser Phe Thr Pro Ile
80 85 90TTT CAA TGG TAC CAC CCC AAT ATC AAC CCG TAT CAA CGC AAT GAG TTT 340Phe Gln Trp Tyr His Pro Asn Ile Asn Pro Tyr Gln Arg Asn Glu Phe
95 100 105AAG TTC CAA ATT AGT TTT AGA GTG CCT GTA TTT AGG CAT ATT CTT TGG 388Lys Phe Gln Ile Ser Phe Arg Val Pro Val Phe Arg His Ile Leu Trp
110 115 120ACT AAA GGC ACG CTG TAT TTA GCT TAT ACC CAA ACT GAC TGG TTT CAA 436Thr Lys Gly Thr Leu Tyr Leu Ala Tyr Thr Gln Thr Asp Trp Phe Gln125 130 135 140ATT TAC AAT GAC CCC CAA TCC GCT CCC ATG CGA ATG ATG AAT TTC ATG 484Ile Tyr Asn Asp Pro Gln Ser Ala Pro Met Arg Met Met Asn Phe Met
145 150 155CCT GAA CTC ATT TAT GTT TAT CCT ATC AAT TTT AAA CCT TTT GGG GGT 532Pro Glu Leu Ile Tyr Val Tyr Pro Ile Asn Phe Lys Pro Phe Gly Gly
160 165 170AAA ATA GGG AAT TTT TCT GAA ATT TGG ATA GGT TGG CAG CAC ATT TCT 580Lys Ile Gly Asn Phe Ser Glu Ile Trp Ile Gly Trp Gln His Ile Ser
175 180185AAT GGC GTG GGG GGC GCG CAA TGT TAC CAA CCT TTT AAT AAA GAA GGC 628Asn Gly Val Gly Gly Ala Gln Cys Tyr Gln Pro Phe Asn Lys Glu Gly
190 195 200AAT CCT GAA AAC CAG TTT CCA GGA CAA CCT GTA ATC GTT AAA GAT TAT 676Asn Pro Glu Asn Gln Phe Pro Gly Gln Pro Val Ile Val Lys Asp Tyr205 210 215 220AAT GGG CAA AAA GAT GTG CGC TGG GGG GGG TGT CGT TCG GTG AGC GCG 724Asn Gly Gln Lys Asp Val Arg Trp Gly Gly Cys Arg Ser Val Ser Ala
225 230 235GGG CAA CGC CCT GTG TTT CGT TTG GTG TGG GAA AAG GGA GGC CTA AAA 772Gly Gln Arg Pro Val Phe Arg Leu Val Trp Glu Lys Gly Gly Leu Lys
240 245 250ATC ATG GTC GCT TAT TGG CCC TAT GTC CCT TAT GAT CAA TCC AAT CCT 820Ile Met Val Ala Tyr Trp Pro Tyr Val Pro Tyr Asp Gln Ser Asn Pro
255 260 265AAT TTG ATT GAT TAC ATG GGG TAT GGT AAC GCT AAA ATT GAT TAC AGG 868Asn Leu Ile Asp Tyr Met Gly Tyr Gly Asn Ala Lys Ile Asp Tyr Arg
270 275 280AGA GGG CGC CAC CAT TTT GAA TTG CAG CTT TAT GAT ATT TTC ACG CAA 916Arg Gly Arg His His Phe Glu Leu Gln Leu Tyr Asp Ile Phe Thr Gln285 290 295 300TAC TGG CGT TAT GAT CGC TGG CAT GGA GCT TTC CGC TTA GGC TAT ACC 964Tyr Trp Arg Tyr Asp Arg Trp His Gly Ala Phe Arg Leu Gly Tyr Thr
305 310 315TAT CGC ATT AAC CCT TTT GTG GGG ATT TAT GCG CAG TGG TTT AAC GGC 1012Tyr Arg Ile Asn Pro Phe Val Gly Ile Tyr Ala Gln Trp Phe Asn Gly
320 325 330TAT GGC GAT GGC TTG TAT GAA TAC GAT GTT TTT TCC AAT CGT ATA GGG 1060TyrGly Asp Gly Leu Tyr Glu Tyr Asp Val Phe Ser Asn Arg Ile Gly
335 340 345GTA GGA ATA CGC TTA AAC CCT TAAAAAAGCG TTCTTTTAYG CTATAATTAA GACC 1115Val Gly Ile Arg Leu Asn Pro
350355 AAAAA 1120 (2) sequence 1342 data: (i) sequence characteristics: length (A): 355 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1342: met Lys Ser Ile Leu Leu Phe Met Ile Phe Val Val Cys Gln Leu Glu 151015 Gly Lys Lys Phe Ser Gln Asp Asn Phe Lys Val Asp Tyr Asn Tyr Tyr
20 25 30Leu Arg Lys Gln Asp Leu His Ile Ile Lys Thr Gln Asn Asp Leu Ser
35 40 45Asn Ser Trp Tyr Leu Pro Pro Gln Lys Ala Pro Lys Glu His Ser Trp
50 55 60Val Asp Phe Ala Lys Lys Tyr Leu Asn Met Met Asp Tyr Leu Gly Thr65 70 75 80Tyr Phe Leu Pro Phe Tyr His Ser Phe Thr Pro Ile Phe Gln Trp Tyr
85 90 95His Pro Asn Ile Asn Pro Tyr Gln Arg Asn Glu Phe Lys Phe Gln Ile
100 105 110Ser Phe Arg Val Pro Val Phe Arg His Ile Leu Trp Thr Lys Gly Thr
115 120 125Leu Tyr Leu Ala Tyr Thr Gln Thr Asp Trp Phe Gln Ile Tyr Asn Asp
130 135 140Pro Gln Ser Ala Pro Met Arg Met Met Asn Phe Met Pro Glu Leu Ile145 150 155 160Tyr Val Tyr Pro Ile Asn Phe Lys Pro Phe Gly Gly Lys Ile Gly Asn
165 170175Phe Ser Glu Ile Trp Ile Gly Trp Gln His Ile Ser Asn Gly Val Gly
180 185 190Gly Ala Gln Cys Tyr Gln Pro Phe Asn Lys Glu Gly Asn Pro Glu Asn
195 200 205Gln Phe Pro Gly Gln Pro Val Ile Val Lys Asp Tyr Asn Gly Gln Lys
210 215 220Asp Val Arg Trp Gly Gly Cys Arg Ser Val Ser Ala Gly Gln Arg Pro225 230 235 240Val Phe Arg Leu Val Trp Glu Lys Gly Gly Leu Lys Ile Met Val Ala
245 250 255Tyr Trp Pro Tyr Val Pro Tyr Asp Gln Ser Asn Pro Asn Leu Ile Asp
260 265 270Tyr Met Gly Tyr Gly Asn Ala Lys Ile Asp Tyr Arg Arg Gly Arg His
275 280 285His Phe Glu Leu Gln Leu Tyr Asp Ile Phe Thr Gln Tyr Trp Arg Tyr
290 295 300Asp Arg Trp His Gly Ala Phe Arg Leu Gly Tyr Thr Tyr Arg Ile Asn305 310 315 320Pro Phe Val Gly Ile Tyr Ala Gln Trp Phe Asn Gly Tyr Gly Asp Gly
325 330 335Leu Tyr Glu Tyr Asp Val Phe Ser Asn Arg Ile Gly Val Gly Ile Arg
340 345 350Leu Asn Pro
355 (2) sequence 1343 data: (i) sequence characteristics: length (A): 697bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 669 (D) other information: (xi) Description of the sequence: sequence 1343: AAAAAATTCA TTTTATCTTT TAGAGGGTTT TTA ATG TCT TAT TTT AAG AAT GCT 54
Met Ser Tyr Phe Lys Asn Ala
1 5TTC AAT CAA AAA TCT TTA ATA GAT GAT TCT AGT GTG TAT TTA GAG CCT 102Phe Asn Gln Lys Ser Leu Ile Asp Asp Ser Ser Val Tyr Leu Glu Pro
10 15 20TGT TCT AGC TCT AAT TTC ATA GAA TTA AAA CGC ATG CAT TAT AAT GAA 150Cys Ser Ser Ser Asn Phe Ile Glu Leu Lys Arg Met His Tyr Asn Glu
25 30 35GAG AAT ACT AAG AAA ACA TGG GAT ATT ATT AAG TCT TTA GAC AGC GTG 198Glu Asn Thr Lys Lys Thr Trp Asp Ile Ile Lys Ser Leu Asp Ser Val40 45 50 55GCG GTT TTA CTC TAT GAA AAA GAA TCC GAT TGC TTT GTG ATT GTG AAA 246Ala Val Leu Leu Tyr Glu Lys Glu Ser Asp Cys Phe Val Ile Val Lys
60 65 70CAA TTC CGC CCA GCC ATT TAT GCG CGC CGT TTT CAT TTT AAG TGC GAT 294Gln Phe Arg Pro Ala Ile Tyr Ala Arg Arg Phe His Phe Lys Cys Asp
75 80 85CAA GAT CAA ACT ATT GAC GGA TAC ACT TAT GAA TTG TGC GCA GGG CTT 342Gln Asp Gln Thr Ile Asp Gly Tyr Thr Tyr Glu Leu Cys Ala Gly Leu
90 95 100GTG GAT AAA GCT AAT AAG AGT TTA GAA GAA ATC GCT TGC GAA GAA GCG 390Val Asp Lys Ala Asn Lys Ser Leu Glu Glu Ile Ala Cys Glu Glu Ala
105 110 115CTA GAA GAA TGC GGT TAT CAA ATT AGC CCT AAA AAT TTA GAA ACC ATA 438Leu Glu Glu Cys Gly Tyr Gln Ile Ser Pro Lys Asn Leu Glu Thr Ile120 125 130 135GGC CAA TTT TAT AGC GCG ACT GGG TTG AGT GGG AGT TTG CAA ACG CTC 486Gly Gln Phe Tyr SerAla Thr Gly Leu Ser Gly Ser Leu Gln Thr Leu
140 145 150TAT TAC GCT GAA GTG CAT AAG AAT TTG AAA GTT TCA AAG GGT GGG GGG 534Tyr Tyr Ala Glu Val His Lys Asn Leu Lys Val Ser Lys Gly Gly Gly
155 160 165ATT GAT ACC GAA AGG ATT GAA GTG CTG TTT TTA GAG CGA TCA AAA GCT 582Ile Asp Thr Glu Arg Ile Glu Val Leu Phe Leu Glu Arg Ser Lys Ala
170 175 180CTT GAT TTT ATA ATG GAT TTT CAA TAC GCT AAA ACC ACC GGA TTG TCT 630Leu Asp Phe Ile Met Asp Phe Gln Tyr Ala Lys Thr Thr Gly Leu Ser
185190195 TTA GCC ATT TTA TGG CAT TTA AAA AAG TTT AAA AAT GTT TAAAAGGAAT TT 681Leu Ala Ile Leu Trp His Leu Lys Lys Phe Lys Asn Val 200205210 TATGTTAAGG CTTTTG 697 (2) sequence 1344 data: (i) sequence characteristics: length (A): 212 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence l 344: met Ser Tyr Phe Lys Asn Ala Phe Asn Gln Lys Ser Leu Ile Asp Asp 151015 Ser Ser Val Tyr Leu Glu Pro Cys Ser Ser Ser Asn Phe Ile Glu Leu
20 25 30Lys Arg Met His Tyr Asn Glu Glu Asn Thr Lys Lys Thr Trp Asp Ile
35 40 45Ile Lys Ser Leu Asp Ser Val Ala Val Leu Leu Tyr Glu Lys Glu Ser
50 55 60Asp Cys Phe Val Ile Val Lys Gln Phe Arg Pro Ala Ile Tyr Ala Arg65 70 75 80Arg Phe His Phe Lys Cys Asp Gln Asp Gln Thr Ile Asp Gly Tyr Thr
85 90 95Tyr Glu Leu Cys Ala Gly Leu Val Asp Lys Ala Asn Lys Ser Leu Glu
100 105 110Glu Ile Ala Cys Glu Glu Ala Leu Glu Glu Cys Gly Tyr Gln Ile Ser
115 120 125Pro Lys Asn Leu Glu Thr Ile Gly Gln Phe Tyr Ser Ala Thr Gly Leu
130 135 140Ser Gly Ser Leu Gln Thr Leu Tyr Tyr Ala Glu Val His Lys Asn Leu145 150 155 160Lys Val Ser Lys Gly Gly Gly Ile Asp Thr Glu Arg Ile Glu Val Leu
165 170 175Phe Leu Glu Arg Ser Lys Ala Leu Asp Phe Ile Met Asp Phe Gln Tyr
180 185 190Ala Lys Thr Thr Gly Leu Ser Leu Ala Ile Leu Trp His Leu Lys Lys
195 200 205Phe Lys Asn Val
210 (2) sequence 1345 data: (i) sequence characteristics: length (A): 2071bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 2022 (D) other information: (xi) Description of the sequence: sequence 1345: TGCGAACAAT TATGGGATGA TATTATAAAA ATTGGTGGGA ATGATAAG ATG AAC GGA 57
Met Asn Gly
1CAT TTT ATC GGT TCT ATT TTG TAT GTG CTA GAT AGT AAT ACG CAC TCT 105His Phe Ile Gly Ser Ile Leu Tyr Val Leu Asp Ser Asn Thr His Ser
5 10 15AAC AAT ACA TTA CTC ATC ATT GAC GGC CAA CAA AGG CTC ACC ACT ATC 153Asn Asn Thr Leu Leu Ile Ile Asp Gly Gln Gln Arg Leu Thr Thr Ile20 25 30 35ACG CTT TTA CTC ATC GCT TTA AGG AAT CAT CTA AGC GAA GAA GTT GAA 201Thr Leu Leu Leu Ile Ala Leu Arg Asn His Leu Ser Glu Glu Val Glu
40 45 50ATT TTG GAG AAA TTT TCG CGT AAA GAA ATA GAG AGC TAT CTT ATC AAC 249Ile Leu Glu Lys Phe Ser Arg Lys Glu Ile Glu Ser Tyr Leu Ile Asn
55 60 65AGC AAT AAG GAC GGC GAT AAG AAA TTC AGG CTC ATT CTT TCA GAG TCC 297Ser Asn Lys Asp Gly Asp Lys Lys Phe Arg Leu Ile Leu Ser Glu Ser
70 75 80GAT AAA GAC ACC TTG CTG TCT TTG ATT GAT AAA AAC AAA AGA AAG CCG 345Asp Lys Asp Thr Leu Leu Ser Leu Ile Asp Lys Asn Lys Arg Lys Pro
85 90 95AGC GAG CCT TCG GTA AAA ATA GTG GAA AAT TTT GAA TTG TTT GAA AAA 393Ser Glu Pro Ser Val Lys Ile Val Glu Asn Phe Glu Leu Phe Glu Lys100 105 110 115TGG ATC AGT GAA AAC ACC GAC AAA CTA GAA ACG ATT TTT AAA GGA TTA 441Trp Ile Ser Glu Asn Thr Asp Lys Leu Glu Thr Ile Phe Lys Gly Leu
120 125 130AAA AAA CTC ATG ATA GTT TGG ATT TCT TTA GAT AAA GGA AAA GAT GAT 489Lys Lys Leu Met Ile Val Trp Ile Ser Leu Asp Lys Gly Lys Asp Asp
135 140 145CCT CAA CTT ATT TTT GAG AGC ATG AAC TCA AAA GAT ATC GAA CTC ACG 537Pro Gln Leu Ile Phe Glu Ser Met Asn Ser Lys Asp Ile Glu Leu Thr
150 155 160CAA ACG GAT TTG ATC AGA AAT TAT ATC GTA ATG GAA ACG GAG GTT GAA 585Gln Thr Asp Leu Ile Arg Asn Tyr Ile Val Met Glu Thr Glu Val Glu
165 170 175AAA CAG GAA GAC TTT TAT AAT CAA TAT TGG AGG GCT ATG GAG GAG AGA 633Lys Gln Glu Asp Phe Tyr Asn Gln Tyr TrpArg Ala Met Glu Glu Arg180 185 190 195TTT GAA CAA AAT GAA ACA TTG TTT AAT CGG TTT GTC CGG CAT TAT CTC 681Phe Glu Gln Asn Glu Thr Leu Phe Asn Arg Phe Val Arg His Tyr Leu
200 205 210ACG ATC AAA ATA GGA AAG ATT CCC AAT GAG AAA AGA GTT TAT GAA GCT 729Thr Ile Lys Ile Gly Lys Ile Pro Asn Glu Lys Arg Val Tyr Glu Ala
215 220 225TTC AAG GAT TAC CGG CAA AAA AAG GGG ATA GAA ATA GAG GAT TTA TTA 777Phe Lys Asp Tyr Arg Gln Lys Lys Gly Ile Glu Ile Glu Asp Leu Leu
230 235 240AAA GAT TTA CAA AAA TAC TGC GGG TAT TTT TGC CAG ATT GCA TTC AAA 825Lys Asp Leu Gln Lys Tyr Cys Gly Tyr Phe Cys Gln Ile Ala Phe Lys
245 250 255AAA GAA GAC GAT AAA GAT TTA AAC AAG GCT TTA AGT TTT TTG GTG AAT 873Lys Glu Asp Asp Lys Asp Leu Asn Lys Ala Leu Ser Phe Leu Val Asn260 265 270 275TTA GAG ATG GAT GTG ATC TAT CCG CTA CTA CTA GAG CTT TAT AGC GAT 921Leu Glu Met Asp Val Ile Tyr Pro Leu Leu Leu Glu Leu Tyr Ser Asp
280 285 290TAT AAG GAT GGC GTT TTA TCC AAG CAG GAT TTT ATC CCT ATT ATC TAT 969Tyr Lys Asp Gly Val Leu Ser Lys Gln Asp Phe Ile Pro Ile Ile Tyr
295 300 305TTA ATA GAG AGC TAT ATT TGC AGA AGG GCG GTG TGT GGG CTT GGC ACA 1017Leu Ile Glu Ser Tyr Ile Cys Arg Arg Ala Val Cys Gly Leu Gly Thr
310 315 320AAT AGT CTC AAT AAA GTT TTT CCC TCT TTT ACA AAG CAC ATC CAA AAA 1065Asn Ser Leu Asn Lys Val Phe Pro Ser Phe Thr Lys His Ile Gln Lys
325330 335GAT GAA TAT TTT AAA AGC CTA AAG GCG CAT TTT GTC TGT CTG ACA GAA 1113Asp Glu Tyr Phe Lys Ser Leu Lys Ala His Phe Val Cys Leu Thr Glu340 345 350 355AAA CAA AGA TTT CCA AAC AAT GAC GAG TTT AAA AAG CTT TTT ATT ACG 1161Lys Gln Arg Phe Pro Asn Asn Asp Glu Phe Lys Lys Leu Phe Ile Thr
360 365 370ATA GAT TTT TAT AAG TTT AAA AAA AAT AAA TAC TTT CTT GAA AGG TTA 1209Ile Asp Phe Tyr Lys Phe Lys Lys Asn Lys Tyr Phe Leu Glu Arg Leu
375 380 385GAA AAT TTT GAC ACA AAA GAA CCG GTC GAT ACT CAA AAA TGC AAT ATA 1257Glu Asn Phe Asp Thr Lys Glu Pro Val Asp Thr Gln Lys Cys Asn Ile
390 395 400GAA CAT ATA ATG CCT CAA ACC CTT ACT CCA GAA TGG CAA AGG GAT TTG 1305Glu His Ile Met Pro Gln Thr Leu Thr Pro Glu Trp Gln Arg Asp Leu
405 410 415GGT GAA AAT TTT CAA GCA ATA CAC GAG AAA TAC CTC CAC ACA ATA GGG 1353Gly Glu Asn Phe Gln Ala Ile His Glu Lys Tyr Leu His Thr Ile Gly420 425 430 435AAT CTC ACT CTA ACC GGT TAT AAC TCT AAG TAT AGC AAC AAT TCT TTC 1401Asn Leu Thr Leu Thr Gly Tyr Asn Ser Lys Tyr Ser Asn Asn Ser Phe
440 445 450CAA GAA AAA AGA GAT ATG GAG AAG GGC TTT AAA CAA AGC TCA TTA AAA 1449Gln Glu Lys Arg Asp Met Glu Lys Gly Phe Lys Gln Ser Ser Leu Lys
455 460 465CTC AAT CAA AGT TTG AAA GAT TTG GAA TCT TTT GGC GAA AAA GAG ATT 1497Leu Asn Gln Ser Leu Lys Asp Leu Glu Ser Phe Gly Glu Lys Glu Ile
470 475 480GAA AAA AGG GCT AGT GAT TTA GCG GAT TGG GCT TTA AAG ATT TGG ACT 1545Glu Lys Arg Ala Ser Asp Leu Ala Asp Trp Ala Leu Lys Ile Trp Thr
485 490 495TAC CCA ATT CTA GAG GCA GAA ACA TTA GAG GAA TAT AAA CCC AAA AAA 1593Tyr Pro Ile Leu Glu Ala Glu Thr Leu Glu Glu Tyr Lys Pro Lys Lys500 505 510 515GAA AAG AAA GAA AAG AAA GAA AAA GAG GAG TAT AAA CTC AAG AAA GAA 1641Glu Lys Lys Glu Lys Lys Glu Lys Glu Glu Tyr Lys Leu Lys Lys Glu
520 525 530AAA AAG GTT TAT GAT TTA AGC TCT TAT AAG TTT AGC TCT GAT TCA AGG 1689Lys Lys Val Tyr Asp Leu Ser Ser Tyr Lys Phe Ser Ser Asp Ser Arg
535 540 545GAA TTG TTT GAT ATT TTA AGA GAA AAG ATT AAA GCT CTT GAT GAA AGG 1737Glu Leu Phe Asp Ile Leu Arg Glu Lys Ile Lys Ala Leu Asp Glu Arg
550 555 560ATA ACT GAA AAA TTT AAT CAA AAA TAT ATA GCT TAT AAG TTT TGT AAA 1785Ile Thr Glu Lys Phe Asn Gln Lys Tyr Ile Ala Tyr Lys Phe Cys Lys
565 570 575ATA AGT TTT GTG GAT ATT GTT GTG CAA GAA AAA GGC TTA AAA TTG TAT 1833Ile Ser Phe Val Asp Ile Val Val Gln Glu Lys Gly Leu Lys Leu Tyr580 585 590 595TTA AAA ATG AAC TTG AAT GAA TTG CAA GAT GAA ATA AAG GAA AAA CTA 1881Leu Lys Met Asn Leu Asn Glu Leu Gln Asp Glu Ile Lys Glu Lys Leu
600 605 610AAA ATT AGA GAC GTT TCT AAT ATC GGT CGT CCA TGC GTT GGA AAC ATG 1929Lys Ile Arg Asp Val Ser Asn Ile Gly Arg Pro Cys Val Gly Asn Met
615 620 625GAA GTA GAG CTA GAA ACA AAA GAA AAT ATC CCT TAT TGT TTG GGA TTG 1977Glu Val Glu Leu Glu Thr Lys Glu Asn Ile Pro Tyr Cys Leu Gly Leu
630 635 640ATC AAG CAG GCT TTA GAA AAA CAG ATG GGT GGT AGG AAT AGG CAA TAAAA 2027Ile Lys Gln Ala Leu Glu Lys Gln Met Gly Gly Arg Asn Arg Gln
645650655 ACCCAACTTA TTCAAAATAA AGAGTATAAT TACAAATTAC TTAC 2071 (2) sequence 1346 data: (i) sequence characteristics: length (A): 658 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1346: met Asn Gly His Phe Ile Gly Ser Ile Leu Tyr Val Leu Asp Ser Asn 151015 Thr His Ser Asn Asn Thr Leu Leu Ile Ile Asp Gly Gln Gln Arg Leu
20 25 30Thr Thr Ile Thr Leu Leu Leu Ile Ala Leu Arg Asn His Leu Ser Glu
35 40 45Glu Val Glu Ile Leu Glu Lys Phe Ser Arg Lys Glu Ile Glu Ser Tyr
50 55 60Leu Ile Asn Ser Asn Lys Asp Gly Asp Lys Lys Phe Arg Leu Ile Leu65 70 75 80Ser Glu Ser Asp Lys Asp Thr Leu Leu Ser Leu Ile Asp Lys Asn Lys
85 90 95Arg Lys Pro Ser Glu Pro Ser Val Lys Ile Val Glu Asn Phe Glu Leu
100 105 110Phe Glu Lys Trp Ile Ser Glu Asn Thr Asp Lys Leu Glu Thr Ile Phe
115 120 125Lys Gly Leu Lys Lys Leu Met Ile Val Trp Ile Ser Leu Asp Lys Gly
130 135 140Lys Asp Asp Pro Gln Leu Ile Phe Glu Ser Met Asn Ser Lys Asp Ile145 150 155 160Glu Leu Thr Gln Thr Asp Leu Ile Arg Asn Tyr Ile Val Met Glu Thr
165 170175Glu Val Glu Lys Gln Glu Asp Phe Tyr Asn Gln Tyr Trp Arg Ala Met
180 185 190Glu Glu Arg Phe Glu Gln Asn Glu Thr Leu Phe Asn Arg Phe Val Arg
195 200 205His Tyr Leu Thr Ile Lys Ile Gly Lys Ile Pro Asn Glu Lys Arg Val
210 215 220Tyr Glu Ala Phe Lys Asp Tyr Arg Gln Lys Lys Gly Ile Glu Ile Glu225 230 235 240Asp Leu Leu Lys Asp Leu Gln Lys Tyr Cys Gly Tyr Phe Cys Gln Ile
245 250 255Ala Phe Lys Lys Glu Asp Asp Lys Asp Leu Asn Lys Ala Leu Ser Phe
260 265 270Leu Val Asn Leu Glu Met Asp Val Ile Tyr Pro Leu Leu Leu Glu Leu
275 280 285Tyr Ser Asp Tyr Lys Asp Gly Val Leu Ser Lys Gln Asp Phe Ile Pro
290 295 300Ile Ile Tyr Leu Ile Glu Ser Tyr Ile Cys Arg Arg Ala Val Cys Gly305 310 315 320Leu Gly Thr Asn Ser Leu Asn Lys Val Phe Pro Ser Phe Thr Lys His
325 330 335Ile Gln Lys Asp Glu Tyr Phe Lys Ser Leu Lys Ala His Phe Val Cys
340 345 350Leu Thr Glu Lys Gln Arg Phe Pro Asn Asn Asp Glu Phe Lys Lys Leu
355 360 365Phe Ile Thr Ile Asp Phe Tyr Lys Phe Lys Lys Asn Lys Tyr Phe Leu
370 375 380Glu Arg Leu Glu Asn Phe Asp Thr Lys Glu Pro Val Asp Thr Gln Lys385 390 395400Cys Asn Ile Glu His Ile Met Pro Gln Thr Leu Thr Pro Glu Trp Gln
405 410 415Arg Asp Leu Gly Glu Asn Phe Gln Ala Ile His Glu Lys Tyr Leu His
420 425 430Thr Ile Gly Asn Leu Thr Leu Thr Gly Tyr Asn Ser Lys Tyr Ser Asn
435 440 445Asn Ser Phe Gln Glu Lys Arg Asp Met Glu Lys Gly Phe Lys Gln Ser
450 455 460Ser Leu Lys Leu Asn Gln Ser Leu Lys Asp Leu Glu Ser Phe Gly Glu465 470 475 480Lys Glu Ile Glu Lys Arg Ala Ser Asp Leu Ala Asp Trp Ala Leu Lys
485 490 495Ile Trp Thr Tyr Pro Ile Leu Glu Ala Glu Thr Leu Glu Glu Tyr Lys
500 505 510Pro Lys Lys Glu Lys Lys Glu Lys Lys Glu Lys Glu Glu Tyr Lys Leu
515 520 525Lys Lys Glu Lys Lys Val Tyr Asp Leu Ser Ser Tyr Lys Phe Ser Ser
530 535 540Asp Ser Arg Glu Leu Phe Asp Ile Leu Arg Glu Lys Ile Lys Ala Leu545 550 555 560Asp Glu Arg Ile Thr Glu Lys Phe Asn Gln Lys Tyr Ile Ala Tyr Lys
565 570 575Phe Cys Lys Ile Ser Phe Val Asp Ile Val Val Gln Glu Lys Gly Leu
580 585 590Lys Leu Tyr Leu Lys Met Asn Leu Asn Glu Leu Gln Asp Glu Ile Lys
595 600 605Glu Lys Leu Lys Ile Arg Asp Val Ser Asn Ile Gly Arg Pro Cys Val
610 615 620Gly Asn Met Glu Val Glu Leu Glu Thr Lys Glu Asn Ile Pro Tyr Cys625 630 635 640Leu Gly Leu Ile Lys Gln Ala Leu Glu Lys Gln Met Gly Gly Arg Asn
645650655 Arg Gln (2) sequence 1347 data: (i) sequence characteristics: length (A): 598bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 558 (D) other information: (xi) Description of the sequence: sequence 1347: GTGGTGGCTG AGTAGAAA ATG TTT GAA GCG ACG ACG ATT TTA GGC TAT AGA 51
Met Phe Glu Ala Thr Thr Ile Leu Gly Tyr Arg
1 5 10GGG GAA TTG AAT CAT AAA AAG TTC GCG CTC ATT GGA GGC GAT GGG CAG 99Gly Glu Leu Asn His Lys Lys Phe Ala Leu Ile Gly Gly Asp Gly Gln
15 20 25GTA ACT TTG GGT AAT TGC GTG GTC AAA GCC AAT GCG ACA AAA ATC AGA 147Val Thr Leu Gly Asn Cys Val Val Lys Ala Asn Ala Thr Lys Ile Arg
30 35 40AGC TTG TAT CAC AAC CAG GTT TTA AGC GGG TTT GCC GGA AGC ACC GCG 195Ser Leu Tyr His Asn Gln Val Leu Ser Gly Phe Ala Gly Ser Thr Ala
45 50 55GAC GCT TTT AGT TTG TTT GAT ATG TTT GAA CGC ATT TTA GAG AGC AAA 243Asp Ala Phe Ser Leu Phe Asp Met Phe Glu Arg Ile Leu Glu Ser Lys60 65 70 75AAG GGG GAT TTG TTT AAA AGC GTG GTG GAT TTC AGT AAA GAA TGG CGC 291Lys Gly Asp Leu Phe Lys Ser Val Val Asp Phe Ser Lys Glu Trp Arg
80 85 90AAA GAT AAG TAT TTA CGC CGA CTG GAA GCG ATG ATG ATC GTT TTA AAC 339Lys Asp Lys Tyr Leu Arg Arg Leu Glu Ala Met Met Ile Val Leu Asn
95 100 105TTC GAT CAC ATT TTC ATT TTG AGC GGC ATG GGC GAT GTT TTA GAA GCT 387Phe Asp His Ile Phe Ile Leu Ser Gly Met Gly Asp Val Leu Glu Ala
110 115 120GAA GAC AAT AAG ATC GCT GCT ATT GGG AGT GGG GGG AAT TAC GCT TTA 435Glu Asp Asn Lys Ile Ala Ala Ile Gly Ser Gly Gly Asn Tyr Ala Leu
125 130 135AGC GCG GCT AGG GCT TTA GAT CAT TTC GCT CAT TTA GAG CCT AGA AAA 483Ser Ala Ala Arg Ala Leu Asp His Phe Ala His Leu Glu Pro Arg Lys140 145 150 155CTT GTA GAA GAG TCC TTA AAA ATC GCA GGG GAT CTT TGC ATT TAC ACC 531Leu Val Glu Glu Ser Leu Lys Ile Ala Gly Asp Leu Cys Ile Tyr Thr
160 165 170AAC ACG AAT ATT AAA ATT TTG GAG CTT TAATGTCTAA ATTGAATATG ACCCCAC 585Asn Thr Asn Ile Lys Ile Leu Glu Leu
175180 GAGAAATTGT CGC 598 (2) sequence 1348 data: (i) sequence characteristics: length (A): 180 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1348: met Phe Glu Ala Thr Thr Ile Leu Gly Tyr Arg Gly Glu Leu Asn His 151015 Lys Lys Phe Ala Leu Ile Gly Gly Asp Gly Gln Val Thr Leu Gly Asn
20 25 30Cys Val Val Lys Ala Asn Ala Thr Lys Ile Arg Ser Leu Tyr His Asn
35 40 45Gln Val Leu Ser Gly Phe Ala Gly Ser Thr Ala Asp Ala Phe Ser Leu
50 55 60Phe Asp Met Phe Glu Arg Ile Leu Glu Ser Lys Lys Gly Asp Leu Phe65 70 7580Lys Ser Val Val Asp Phe Ser Lys Glu Trp Arg Lys Asp Lys Tyr Leu
85 90 95Arg Arg Leu Glu Ala Met Met Ile Val Leu Asn Phe Asp His Ile Phe
100 105 110Ile Leu Ser Gly Met Gly Asp Val Leu Glu Ala Glu Asp Asn Lys Ile
115 120 125Ala Ala Ile Gly Ser Gly Gly Asn Tyr Ala Leu Ser Ala Ala Arg Ala
130 135 140Leu Asp His Phe Ala His Leu Glu Pro Arg Lys Leu Val Glu Glu Ser145 150 155 160Leu Lys Ile Ala Gly Asp Leu Cys Ile Tyr Thr Asn Thr Asn Ile Lys
165 170 175Ile Leu Glu Leu
180 (2) sequence 1349 data: (i) sequence characteristics: length (A): 450bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 396 (D) other information: (xi) Description of the sequence: sequence 1349: TGTTTCATAG TAACAAATTG AAAATATACC ATT ATG TAT GGA GGT AAT GCT ATG 54
Met Tyr Gly Gly Asn Ala Met
1 5GCT GAC ACA ATC AAT ACA ACT GAA GCA ACT CAT GAA ACA AAA AAA CCA 102Ala Asp Thr Ile Asn Thr Thr Glu Ala Thr His Glu Thr Lys Lys Pro
10 15 20AAC GCT TTT GTA AAT TTT TTC AAA AAC AAT TTG ACT GAT AAG CGT TAT 150Asn Ala Phe Val Asn Phe Phe Lys Asn Asn Leu Thr Asp Lys Arg Tyr
25 30 35GAT TCA TTA GGT CTC ATT GGA GCA GGG GTT TTA TGT TGT GTC TTG AGC198Asp Ser Leu Gly Leu Ile Gly Ala Gly Val Leu Cys Cys Val Leu Ser40 45 50 55GGT GCT ATG GGG ATT GTT GGG ATA ATC TTT GTC GCA ATA GGA ATC TTT 246Gly Ala Met Gly Ile Val Gly Ile Ile Phe Val Ala Ile Gly Ile Phe
60 65 70TTG TCT TTT TCT AAT ATC AAC TTA GTG AAA TTA GTT GAA AAA TTG TCC 294Leu Ser Phe Ser Asn Ile Asn Leu Val Lys Leu Val Glu Lys Leu Ser
75 80 85AAA AAA CAA TCT AAA GTG CCA ACA ACT GTC AAT AAC GAA ACT CAA AAA 342Lys Lys Gln Ser Lys Val Pro Thr Thr Val Asn Asn Glu Thr Gln Lys
90 95 100TCT CAA GCA ACA AGC GTT ACC AAC GAA CCA ACT GAA GCC AAA GAG ACT 390Ser Gln Ala Thr Ser Val Thr Asn Glu Pro Thr Glu Ala Lys Glu Thr
105110115 AAA GAT TGAGGCAAAA CAACGATTTT GACTGAAGAA AGAATGAGAG AAAATTTCAA AA 448Lys Asp120AT 450 (2) sequence 1350 data: (i) sequence characteristics: length (A): 121 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1350: met Tyr Gly Gly Asn Ala Met Ala Asp Thr Ile Asn Thr Thr Glu Ala 151015 Thr His Glu Thr Lys Lys Pro Asn Ala Phe Val Asn Phe Phe Lys Asn
20 25 30Asn Leu Thr Asp Lys Arg Tyr Asp Ser Leu Gly Leu Ile Gly Ala Gly
35 40 45Val Leu Cys Cys Val Leu Ser Gly Ala Met Gly Ile Val Gly Ile Ile
50 55 60Phe Val Ala Ile Gly Ile Phe Leu Ser Phe Ser Asn Ile Asn Leu Val65 70 75 80Lys Leu Val Glu Lys Leu Ser Lys Lys Gln Ser Lys Val Pro Thr Thr
85 90 95Val Asn Asn Glu Thr Gln Lys Ser Gln Ala Thr Ser Val Thr Asn Glu
100 105 110Pro Thr Glu Ala Lys Glu Thr Lys Asp
115120 (2) sequence 1351 data: (i) sequence characteristics: length (A): 504bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 443 (D) other information: (xi) Description of the sequence: sequence 1351: TAACCATTAG TTTCAAGCAG TATGAAAATC TTCTCCATAT CCATCAAAAA GGTTGCGACA 60ATGAAGTG ATG TGC AGA ACG CTC ATC TCT ATC GCT TTG TTA GAA AGC TCT 110
Met Cys Arg Thr Leu Ile Ser Ile Ala Leu Leu Glu Ser Ser
1 5 10CTA GGG TTG AAC AAC AGG CGA GAA AAA TCC CTT AAA GAC ACT TCT TAT 158Leu Gly Leu Asn Asn Arg Arg Glu Lys Ser Leu Lys Asp Thr Ser Tyr15 20 25 30TCC ATG TTT CAT ATC ACC CTA AAC ACC GCT AAA AAA TTC TAC CCT ACC 206Ser Met Phe His Ile Thr Leu Asn Thr Ala Lys Lys Phe Tyr Pro Thr
35 40 45TAC TCT AAA ACG CTC CTC AAA TTC AAA TTG CTA AAC GAT GTG GGT TTT 254Tyr Ser Lys Thr Leu Leu Lys Phe Lys Leu Leu Asn Asp Val Gly Phe
50 55 60GCG ATC CAA TTA GCC AAA CAA ATT TTA AAA GAA AAT TTT GAT TAT TAC 302Ala Ile Gln Leu Ala Lys Gln Ile Leu Lys Glu Asn Phe Asp Tyr Tyr
65 70 75AAA CAA AAA CAC CCC AAC AAA AGC GTG TAT CAA TTA GTA GAA ATG GCA 350Lys Gln Lys His Pro Asn Lys Ser Val Tyr Gln Leu Val Glu Met Ala
80 85 90ATA GGC GCT TAC AAT GGG GGA ATG AAA CAC AAC CCT AAT GGC GCT TAC 398Ile Gly Ala Tyr Asn Gly Gly Met Lys His Asn Pro Asn Gly Ala Tyr95 100 105 110GTG AAA AAA TTC CGT TGC ATT TAT TCT CAA GTG CGA TAT AAC GAG TAGAG 448Val Lys Lys Phe Arg Cys Ile Tyr Ser Gln Val Arg Tyr Asn Glu
115120125 CATACTCATT TTATAAGCAA TCTTGATGAC ACACTTCTAC TATCTTATGA ATTTAT 504 (2) sequence 1352 data: (i) sequence characteristics: length (A): 125 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1352: met Cys Arg Thr Leu Ile Ser Ile Ala Leu Leu Glu Ser Ser Leu Gly 151015 Leu Asn Asn Arg Arg Glu Lys Ser Leu Lys Asp Thr Ser Tyr Ser Met
20 25 30Phe His Ile Thr Leu Asn Thr Ala Lys Lys Phe Tyr Pro Thr Tyr Ser
35 40 45Lys Thr Leu Leu Lys Phe Lys Leu Leu Asn Asp Val Gly Phe Ala Ile
50 55 60Gln Leu Ala Lys Gln Ile Leu Lys Glu Asn Phe Asp Tyr Tyr Lys Gln65 70 75 80Lys His Pro Asn Lys Ser Val Tyr Gln Leu Val Glu Met Ala Ile Gly
85 90 95Ala Tyr Asn Gly Gly Met Lys His Asn Pro Asn Gly Ala Tyr Val Lys
l00 105 110Lys Phe Arg Cys Ile Tyr Ser Gln Val Arg Tyr Asn Glu
115120125 (2) sequence 1353 data: (i) sequence characteristics: length (A): 2329bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 2274 (D) other information: (xi) Description of the sequence: sequence 1353: ATTTTATATC AAACACAGGTAGTAGGCACA ATG GAA GAC TTT TTG TAT AAC ACC 54
Met Glu Asp Phe Leu Tyr Asn Thr
1 5TTA TAT TTC ATA GAG GAT TAT AAG TTG GTT GTT ATT TTT AGT TTC ATA 102Leu Tyr Phe Ile Glu Asp Tyr Lys Leu Val Val Ile Phe Ser Phe Ile
10 15 20GGG TTA ATA GCG TTA TTT TTT CTT TAC AAA TTC ATA AAA GCT CAA AAA 150Gly Leu Ile Ala Leu Phe Phe Leu Tyr Lys Phe Ile Lys Ala Gln Lys25 30 35 40AAG GCT TTT AAA GAT AAA GCT AAC CAG CCT CAA AAG AAA AAA AGC TTT 198Lys Ala Phe Lys Asp Lys Ala Asn Gln Pro Gln Lys Lys Lys Ser Phe
45 50 55AAA GAA ATC ATT ATA GAT GGG CTG AAA GAA AGG GTT AAA ACC TTT GGC 246Lys Glu Ile Ile Ile Asp Gly Leu Lys Glu Arg Val Lys Thr Phe Gly
60 65 70TTT TGG TTG CAA GCT ATA CTA TTA CTA TCC TAT TCT TTT ATC ACA TCA 294Phe Trp Leu Gln Ala Ile Leu Leu Leu Ser Tyr Ser Phe Ile Thr Ser
75 80 85GGA TTA TTT TTC TTG ATT CTC TTA GGT AAT TTT TAT GAT GAT AAT CGA 342Gly Leu Phe Phe Leu Ile Leu Leu Gly Asn Phe Tyr Asp Asp Asn Arg
90 95 100TCG CCT GAG AGC GAT GAT GAT CTT TTT GAT ATA TGG ATC TAT GCG ATA 390Ser Pro Glu Ser Asp Asp Asp Leu Phe Asp Ile Trp Ile Tyr Ala Ile105 110 115 120CAA GAT TTT CCT AAT TAC TAT TTT AAA GCG CTT GGT TTT AGT TCA CTC 438Gln Asp Phe Pro Asn Tyr Tyr Phe Lys Ala Leu Gly Phe Ser Ser Leu
125 130 135AAG ATT TAT GGG TTC AAT ATA TCC TTA GTC GTA TAT GGT TCT ATT TTA 486Lys IleTyr Gly Phe Asn Ile Ser Leu Val Val Tyr Gly Ser Ile Leu
140 145 150TGC TCT TAT ATC TTC ATT ACC TTT TTT GTG TGG TTC TTA AAA TAC TTA 534Cys Ser Tyr Ile Phe Ile Thr Phe Phe Val Trp Phe Leu Lys Tyr Leu
155 160 165ACT CGG ACT AGA GAT ATA GGA GCG AAT AAA AAA GTT GAT GAT CTC TTT 582Thr Arg Thr Arg Asp Ile Gly Ala Asn Lys Lys Val Asp Asp Leu Phe
170 175 180GGT AGC GCG AGT TGG GAA ACT GAA GAG AAA ATG ATC AAA GCC AAA CTC 630Gly Ser Ala Ser Trp Glu Thr Glu Glu Lys Met Ile Lys Ala Lys Leu185 190 195 200ATC ACG CCC AAC AAT AAA AAA CGC GCC TTT GAC AAA CGA GAG GTG ATT 678Ile Thr Pro Asn Asn Lys Lys Arg Ala Phe Asp Lys Arg Glu Val Ile
205 210 215GTA GGC AGG CGT GGC TTG GGG GAT TTT ATC GCT TAC GCA GGG CAG GCG 726Val Gly Arg Arg Gly Leu Gly Asp Phe Ile Ala Tyr Ala Gly Gln Ala
220 225 230TTC ATT GGC TTG ATT GCT CCT ACT AGA AGC GGT AAG GGG GTG GGT TTC 774Phe Ile Gly Leu Ile Ala Pro Thr Arg Ser Gly Lys Gly Val Gly Phe
235 240 245ATC ATG CCC AAT ATG ATC AAT TAT CCT CAA AAT ATC GTT GTG TTT GAC 822Ile Met Pro Asn Met Ile Asn Tyr Pro Gln Asn Ile Val Val Phe Asp
250 255 260CCT AAA GCT GAC ACT ATG GAG ACT TGC GGA AAA ATC AGA GAA AAA CGC 870Pro Lys Ala Asp Thr Met Glu Thr Cys Gly Lys Ile Arg Glu Lys Arg265 270 275 280TTC AAC CAA AAA GTG TTC ATC TAT GAA CCT TTC TCC TTA AAA ACA CAC 918Phe Asn Gln Lys Val Phe Ile Tyr Glu Pro Phe Ser Leu Lys Thr His
285 290 295CGA TTT AAT CCT TTC GCT TAT GTG GAT TTT GGT AAT GAT GTG GTT TTG 966Arg Phe Asn Pro Phe Ala Tyr Val Asp Phe Gly Asn Asp Val Val Leu
300 305 310ACC GAA GAC ATA CTC TCT CAA ATT GAC ACA CGC CTA AAA GGG CAT GGC 1014Thr Glu Asp Ile Leu Ser Gln Ile Asp Thr Arg Leu Lys Gly His Gly
315 320 325ATG GTG GCT AGT GGA GGG GAT TTT TCC ACT CAA ATC TTT GGA TTA GCA 1062Met Val Ala Ser Gly Gly Asp Phe Ser Thr Gln Ile Phe Gly Leu Ala
330 335 340AAG CTC GTG TTC CCT GAA AGA CCT AAT GAA AAA GAT CCT TTC TTT AGC 1110Lys Leu Val Phe Pro Glu Arg Pro Asn Glu Lys Asp Pro Phe Phe Ser345 350 355 360AAT CAA GCG CGA AAT CTT TTT GTC ATC AAT TGC AAT ATT TAC AGG GAT 1158Asn Gln Ala Arg Asn Leu Phe Val Ile Asn Cys Asn Ile Tyr Arg Asp
365 370 375CTC ATG TGG ACT AAA AAG GGG CTT GAG TTT GTC AAA AGA AAA AAA ATC 1206Leu Met Trp Thr Lys Lys Gly Leu Glu Phe Val Lys Arg Lys Lys Ile
380 385 390ATC ATG CCT GAA ACA CCC ACG ATG TTT TTC ATA GGT TCT ATG GCA AGC 1254Ile Met Pro Glu Thr Pro Thr Met Phe Phe Ile Gly Ser Met Ala Ser
395 400 405GGG ATC AAC TTG ATT GAT GAA GAC ACA AAC ATG GAA AAA GTC GTG TCT 1302Gly Ile Asn Leu Ile Asp Glu Asp Thr Asn Met Glu Lys Val Val Ser
410 415 420TTA ATG GAA TTT TTT GGA GGT GAA GAA GAT AAG AGT GGC GAT AAT CTA 1350Leu Met Glu Phe Phe Gly Gly Glu Glu Asp Lys Ser Gly Asp Asn Leu425 430 435 440AGA GTG CTT AGT CCT GCC ACT AGA AAC ATG TGG AAT AGC TTC AAG ACA 1398Arg Val Leu Ser Pro Ala Thr Arg Asn Met Trp Asn Ser Phe Lys Thr
445 450 455ATG GGC GGC GCT AGA GAA ACT TAT AGC TCG GTT CAA GGG GTA TAC ACT 1446Met Gly Gly Ala Arg Glu Thr Tyr Ser Ser Val Gln Gly Val Tyr Thr
460 465 470TCA GCC TTT GCG CCT TAT AAT AAC GCA ATG ATT AGA AAT TTC ACG AGC 1494Ser Ala Phe Ala Pro Tyr Asn Asn Ala Met Ile Arg Asn Phe Thr Ser
475 480 485GCC AAT GAT TTT GAT TTC AGG CGT TTA AGG ATC GAT GAA GTG AGT ATT 1542Ala Asn Asp Phe Asp Phe Arg Arg Leu Arg Ile Asp Glu Val Ser Ile
490 495 500GGT GTG ATC GCT AAT CCT AAA GAA AGC ACT ATT GTT GGA CCG ATA TTA 1590Gly Val Ile Ala Asn Pro Lys Glu Ser Thr Ile Val Gly Pro Ile Leu505 510 515 520GAG CTG TTT TTC AAT GTG ATG ATT TAT AGC AAT TTG ATT CTG CCA ATC 1638Glu Leu Phe Phe Asn Val Met Ile Tyr Ser Asn Leu Ile Leu Pro Ile
525 530 535CAT GAT CCA CAG TGC AAA AGA AGT TGC TTG ATG CTC ATG GAC GAA TTC 1686His Asp Pro Gln Cys Lys Arg Ser Cys Leu Met Leu Met Asp Glu Phe
540 545 550ACT TTA TGT GGC TAT TTA GAG ACC TTT GTT AAA GCG GTA GGG ATT ATG 1734Thr Leu Cys Gly Tyr Leu Glu Thr Phe Val Lys Ala Val Gly Ile Met
555 560 565GCA GAA TAC AAC ATG CGC CCC GCT TTT GTG TTT CAA AGT AAG GCG CAA 1782Ala Glu Tyr Asn Met Arg Pro Ala Phe Val Phe Gln Ser Lys Ala Gln
570 575 580CTA GAG AAT GAC CCC CCA CTT GGT TAT GGT AGG AAT GGC GCT AAG ACT 1830Leu Glu AsnAsp Pro Pro Leu Gly Tyr Gly Arg Asn Gly Ala Lys Thr585 590 595 600ATT TTA GAC AAC CTT TCT TTG AAT ATG TAT TAT GGG ATT AAC AAC GAT 1878Ile Leu Asp Asn Leu Ser Leu Asn Met Tyr Tyr Gly Ile Asn Asn Asp
605 610 615AAC TAC TAT GAA CAT TTT GAA AAA CTT TCT AAG GTA TTA GGG AAA TAC 1926Asn Tyr Tyr Glu His Phe Glu Lys Leu Ser Lys Val Leu Gly Lys Tyr
620 625 630ACA AGG CAA GAC GTG AGC CGA AGC ATT GAT GAT AAT ACA GGT AAG ACC 1974Thr Arg Gln Asp Val Ser Arg Ser Ile Asp Asp Asn Thr Gly Lys Thr
635 640 645AAC ACT TCT ATC AGC AAC AAA GAG CGG TTT TTG ATG ACC CCT GAT GAA 2022Asn Thr Ser Ile Ser Asn Lys Glu Arg Phe Leu Met Thr Pro Asp Glu
650 655 660TTG ATG ACT ATG GGC GAT GAG CTT ATC ATT CTA GAG AAT ACG CTC AAA 2070Leu Met Thr Met Gly Asp Glu Leu Ile Ile Leu Glu Asn Thr Leu Lys665 670 675 680CCT ATC AAG TGC CAC AAG GCG CTT TAC TAT GAT GAT CCA TTC TTC ACC 2118Pro Ile Lys Cys His Lys Ala Leu Tyr Tyr Asp Asp Pro Phe Phe Thr
685 690 695GAT GAA CTC ATT AAG GTA AGT CCA AGC TTG AGC AAG AAA TAC AAA TTG 2166Asp Glu Leu Ile Lys Val Ser Pro Ser Leu Ser Lys Lys Tyr Lys Leu
700 705 710GGG AAA GTG CCT AAT CAA GCA ACT TTC TAT GAT GAT TTG CAA GCC GCT 2214Gly Lys Val Pro Asn Gln Ala Thr Phe Tyr Asp Asp Leu Gln Ala Ala
715 720 725AAA ACT AGA GGT GAA TTG AGT TAT GAT AAA TCT TTA GTG CCT GTG GGT 2262Lys Thr Arg Gly Glu Leu Ser Tyr Asp Lys Ser Leu Val Pro Val Gly
730735740 TCA AGT GAA CTG TGATTAAGAC AAAATATCTT AACAAAAAGA AAATTAAAAG ATAAT 2319Ser Ser Glu Leu745 35745 GATATAAATA 2329 (2) SEQ ID NO: (i) sequence characteristics: length (A): 748 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1354: met Glu Asp Phe Leu Tyr Asn Thr Leu Tyr Phe Ile Glu Asp Tyr Lys 151015 Leu Val Val Ile Phe Ser Phe Ile Gly Leu Ile Ala Leu Phe Phe Leu
20 25 30Tyr Lys Phe Ile Lys Ala Gln Lys Lys Ala Phe Lys Asp Lys Ala Asn
35 40 45Gln Pro Gln Lys Lys Lys Ser Phe Lys Glu Ile Ile Ile Asp Gly Leu
50 55 60Lys Glu Arg Val Lys Thr Phe Gly Phe Trp Leu Gln Ala Ile Leu Leu65 70 75 80Leu Ser Tyr Ser Phe Ile Thr Ser Gly Leu Phe Phe Leu Ile Leu Leu
85 90 95Gly Asn Phe Tyr Asp Asp Asn Arg Ser Pro Glu Ser Asp Asp Asp Leu
100 105 110Phe Asp Ile Trp Ile Tyr Ala Ile Gln Asp Phe Pro Asn Tyr Tyr Phe
115 120 125Lys Ala Leu Gly Phe Ser Ser Leu Lys Ile Tyr Gly Phe Asn Ile Ser
130 135 140Leu Val Val Tyr Gly Ser Ile Leu Cys Ser Tyr Ile Phe Ile Thr Phe 145 150 155 160Phe Val Trp Phe Leu Lys Tyr Leu Thr Arg Thr Arg Asp Ile Gly Ala
165 170 175Asn Lys Lys Val Asp Asp Leu Phe Gly Ser Ala Ser Trp Glu Thr Glu
180 185 190Glu LysMet Ile Lys Ala Lys Leu Ile Thr Pro Asn Asn Lys Lys Arg
195 200 205Ala Phe Asp Lys Arg Glu Val Ile Val Gly Arg Arg Gly Leu Gly Asp
210 215 220Phe Ile Ala Tyr Ala Gly Gln Ala Phe Ile Gly Leu Ile Ala Pro Thr225 230 235 240Arg Ser Gly Lys Gly Val Gly Phe Ile Met Pro Asn Met Ile Asn Tyr
245 250 255Pro Gln Asn Ile Val Val Phe Asp Pro Lys Ala Asp Thr Met Glu Thr
260 265 270Cys Gly Lys Ile Arg Glu Lys Arg Phe Asn Gln Lys Val Phe Ile Tyr
275 280 285Glu Pro Phe Ser Leu Lys Thr His Arg Phe Asn Pro Phe Ala Tyr Val
290 295 300Asp Phe Gly Asn Asp Val Val Leu Thr Glu Asp Ile Leu Ser Gln Ile305 310 315 320Asp Thr Arg Leu Lys Gly His Gly Met Val Ala Ser Gly Gly Asp Phe
325 330 335Ser Thr Gln Ile Phe Gly Leu Ala Lys Leu Val Phe Pro Glu Arg Pro
340 345 350Asn Glu Lys Asp Pro Phe Phe Ser Asn Gln Ala Arg Asn Leu Phe Val
355 360 365Ile Asn Cys Asn Ile Tyr Arg Asp Leu Met Trp Thr Lys Lys Gly Leu
370 375 380Glu Phe Val Lys Arg Lys Lys Ile Ile Met Pro Glu Thr Pro Thr Met385 390 395 400Phe Phe Ile Gly Ser Met Ala Ser Gly Ile Asn Leu Ile Asp Glu Asp
405 410 415Thr Asn Met Glu Lys Val Val Ser Leu Met Glu Phe Phe Gly Gly Glu
420 425 430Glu Asp Lys Ser Gly Asp Asn Leu Arg Val Leu Ser Pro Ala Thr Arg
435 440 445Asn Met Trp Asn Ser Phe Lys Thr Met Gly Gly Ala Arg Glu Thr Tyr
450 455 460Ser Ser Val Gln Gly Val Tyr Thr Ser Ala Phe Ala Pro Tyr Asn Asn465 470 475 480Ala Met Ile Arg Asn Phe Thr Ser Ala Asn Asp Phe Asp Phe Arg Arg
485 490 495Leu Arg Ile Asp Glu Val Ser Ile Gly Val Ile Ala Asn Pro Lys Glu
500 505 510Ser Thr Ile Val Gly Pro Ile Leu Glu Leu Phe Phe Asn Val Met Ile
515 520 525Tyr Ser Asn Leu Ile Leu Pro Ile His Asp Pro Gln Cys Lys Arg Ser
530 535 540Cys Leu Met Leu Met Asp Glu Phe Thr Leu Cys Gly Tyr Leu Glu Thr545 550 555 560Phe Val Lys Ala Val Gly Ile Met Ala Glu Tyr Asn Met Arg Pro Ala
565 570 575Phe Val Phe Gln Ser Lys Ala Gln Leu Glu Asn Asp Pro Pro Leu Gly
580 585 590Tyr Gly Arg Asn Gly Ala Lys Thr Ile Leu Asp Asn Leu Ser Leu Asn
595 600 605Met Tyr Tyr Gly Ile Asn Asn Asp Asn Tyr Tyr Glu His Phe Glu Lys
610 615 620Leu Ser Lys Val Leu Gly Lys Tyr Thr Arg Gln Asp Val Ser Arg Ser625 630 635 640Ile Asp Asp Asn Thr Gly Lys Thr Asn Thr Ser Ile Ser Asn Lys Glu
645 650 655Arg Phe Leu Met Thr Pro Asp Glu Leu Met Thr Met Gly Asp Glu Leu
660 665 670Ile Ile Leu Glu Asn Thr Leu Lys Pro Ile Lys Cys His Lys Ala Leu
675 680 685Tyr Tyr Asp Asp Pro Phe Phe Thr Asp Glu Leu Ile Lys Val Ser Pro
690 695 700Ser Leu Ser Lys Lys Tyr Lys Leu Gly Lys Val Pro Asn Gln Ala Thr705 710 715 720Phe Tyr Asp Asp Leu Gln Ala Ala Lys Thr Arg Gly Glu Leu Ser Tyr
725 730 735Asp Lys Ser Leu Val Pro Val Gly Ser Ser Glu Leu
740745 (2) sequence 1355 data: (i) sequence characteristics: length (A): 1037 bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 1008 (D) other information: (xi) Description of the sequence: sequence 1355: TAAATTTGGA ATAAGAAC ATG ACT GAA GAC AGA TTG AGT GCA GAA GAT AAA 51
Met Thr Glu Asp Arg Leu Ser Ala Glu Asp Lys
1 5 10AAG TTT CTA GAA GTA GAA AGA GCT TTA AAA GAA GCG GCA TTA AAT CCT 99Lys Phe Leu Glu Val Glu Arg Ala Leu Lys Glu Ala Ala Leu Asn Pro
15 20 25CTA AGG CAT GCT ACT GAA GAA CTT TTT GGT GAT TTT TTA AAA ATG GAA 147Leu Arg His Ala Thr Glu Glu Leu Phe Gly Asp Phe Leu Lys Met Glu
30 35 40AAT ATC ACT GAG ATT TGT TAC AAT GGG AAC AAG GTT GTA TGG GTT TTA 195Asn Ile Thr Glu Ile Cys Tyr Asn Gly Asn Lys Val Val Trp Val Leu
45 50 55AAA AAT AAT GGC GAA TGG CAA CCA TTT GAT GTG AGA GAC AGG AAA GCC 243Lys Asn Asn Gly Glu Trp Gln Pro Phe Asp Val Arg Asp Arg Lys Ala60 65 70 75TTT AGC CTG TCT CGT TTA ATG CAT TTT GCT CGG TGT TGT GCA AGT TTT 291Phe Ser Leu Ser Arg Leu Met His Phe Ala Arg Cys Cys Ala Ser Phe
80 85 90AAG AAA AAA ACA ATA GAC AAC TAT GAA AAT CCT ATT TTG AGC AGC AAT 339Lys Lys Lys Thr Ile Asp Asn Tyr Glu Asn Pro Ile Leu Ser Ser Asn
95 100 105TTA GCG AAT GGT GAA AGG GTG CAG ATT GTC CTT TCC CCT GTT ACA GTT 387Leu Ala Asn Gly Glu Arg Val Gln Ile Val Leu Ser Pro Val Thr Val
110 115 120AAT GAT GAA ACC ATT TCC ATA TCC ATA AGG ATA CCT AGC AAA ACA ACC 435Asn Asp Glu Thr Ile Ser Ile Ser Ile Arg Ile Pro Ser Lys Thr Thr
125 130 135TAT CCT CAT AGC TTC TTT GAA GAG CAA GGT TTT TAT AAT CTA CTA GAC 483Tyr Pro His Ser Phe Phe Glu Glu Gln Gly Phe Tyr Asn Leu Leu Asp140 145 150 155AAC AAA GAA CAA GCG ATC AGC GCG ATT AAA GAT GGT ATT GCT ATT GGT 531Asn Lys Glu Gln Ala Ile Ser Ala Ile Lys Asp Gly Ile Ala Ile Gly
160 165 170AAA AAT GTG ATT GTT TGT GGT GGC ACA GGA AGC GGT AAA ACG ACT TAT 579Lys Asn Val Ile Val Cys Gly Gly Thr Gly Ser Gly Lys Thr Thr Tyr
175 180 185ATC AAA AGC ATC ATG GAG TTT ATC CCT AAA GAA GAA AGG ATC ATA TCC 627Ile Lys Ser Ile Met Glu Phe Ile Pro Lys Glu Glu Arg Ile Ile Ser
190 195 200ATT GAA GAC ACC GAA GAG ATT GTA TTC AAA CAC CAC AAA AAC TAC ACA 675Ile Glu Asp Thr Glu Glu Ile Val Phe Lys His His Lys Asn Tyr Thr
205 210 215CAG CTT TTT TTT GGT GGG AAT ATC ACC TCT GCT GAT TGC TTA AAG TCA 723Gln Leu Phe Phe Gly Gly Asn Ile Thr Ser Ala Asp Cys Leu Lys Ser220 225 230 235TGT CTG AGA ATG CGG CCT GAT AGA ATC ATT TTA GGG GAA CTC AGA AGC 771Cys Leu Arg Met Arg Pro Asp Arg Ile Ile Leu Gly Glu Leu Arg Ser
240 245 250AGT GAG GCA TAC GAT TTT TAT AAT GTG CTT TGT AGC GGT CAT AAA GGC 819Ser Glu Ala Tyr Asp Phe Tyr Asn Val Leu Cys Ser Gly His Lys Gly
255 260 265ACA CTA ACC ACT CTG CAT GCA GGG AGC AGT GAA GAA GCG TTT ATC CGT 867Thr Leu Thr Thr Leu His Ala Gly Ser Ser Glu Glu Ala Phe Ile Arg
270 275 280TTG GCC AAC ATG AGT TCA TCT AAT AGC GCA GCA AGG AAT ATC AAG TTT 915Leu Ala Asn Met Ser Ser Ser Asn Ser Ala Ala Arg Asn Ile Lys Phe
285 290 295GAA AGT CTT ATT GAG GGC TTT AAA GAT TTG ATT GAT ATG ATT GTC CAT 963Glu Ser Leu Ile Glu Gly Phe Lys Asp Leu Ile Asp Met Ile Val His300 305 310 315ATC AAC CAC CAC AAA CAG TGT GAT GAA TTT TAT ATC AAA CAC AGG TAGTA 1013Ile Asn His His Lys Gln Cys Asp Glu Phe Tyr Ile Lys His Arg
320325330 GGCACAATGG AAGACTTTTT GTAT 1037 (2) sequence 1356 data: (i) sequence characteristics: length (A): 330 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1356: met Thr Glu Asp ArgLeu Ser Ala Glu Asp Lys Lys Phe Leu Glu Val 151015 Glu Arg Ala Leu Lys Glu Ala Ala Leu Asn Pro Leu Arg His Ala Thr
20 25 30Glu Glu Leu Phe Gly Asp Phe Leu Lys Met Glu Asn Ile Thr Glu Ile
35 40 45Cys Tyr Asn Gly Asn Lys Val Val Trp Val Leu Lys Asn Asn Gly Glu
50 55 60Trp Gln Pro Phe Asp Val Arg Asp Arg Lys Ala Phe Ser Leu Ser Arg65 70 75 80Leu Met His Phe Ala Arg Cys Cys Ala Ser Phe Lys Lys Lys Thr Ile
85 90 95Asp Asn Tyr Glu Asn Pro Ile Leu Ser Ser Asn Leu Ala Asn Gly Glu
100 105 110Arg Val Gln Ile Val Leu Ser Pro Val Thr Val Asn Asp Glu Thr Ile
115 120 125Ser Ile Ser Ile Arg Ile Pro Ser Lys Thr Thr Tyr Pro His Ser Phe
130 135 140Phe Glu Glu Gln Gly Phe Tyr Asn Leu Leu Asp Asn Lys Glu Gln Ala145 150 155 160Ile Ser Ala Ile Lys Asp Gly Ile Ala Ile Gly Lys Asn Val Ile Val
165 170 175Cys Gly Gly Thr Gly Ser Gly Lys Thr Thr Tyr Ile Lys Ser Ile Met
180 185 190Glu Phe Ile Pro Lys Glu Glu Arg Ile Ile Ser Ile Glu Asp Thr Glu
195 200 205Glu Ile Val Phe Lys His His Lys Asn Tyr Thr Gln Leu Phe Phe Gly
210 215 220Gly Asn Ile Thr Ser Ala Asp Cys Leu Lys Ser Cys Leu Arg Met Arg225230 235 240Pro Asp Arg Ile Ile Leu Gly Glu Leu Arg Ser Ser Glu Ala Tyr Asp
245 250 255Phe Tyr Asn Val Leu Cys Ser Gly His Lys Gly Thr Leu Thr Thr Leu
260 265 270His Ala Gly Ser Ser Glu Glu Ala Phe Ile Arg Leu Ala Asn Met Ser
275 280 285Ser Ser Asn Ser Ala Ala Arg Asn Ile Lys Phe Glu Ser Leu Ile Glu
290 295 300Gly Phe Lys Asp Leu Ile Asp Met Ile Val His Ile Asn His His Lys305 310 315 320Gln Cys Asp Glu Phe Tyr Ile Lys His Arg
325330 (2) sequence 1357 data: (i) sequence characteristics: length (A): 5334bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 5250 (D) other information: (xi) Description of the sequence: sequence 1357: TAAATAAAAA GGCGTTAAGA C ATG AAT GAA GAA AAC GAT AAA CTT GAA ACT 51
Met Asn Glu Glu Asn Asp Lys Leu Glu Thr
1 5 10TCT AAA AAA GCC CAA CAA GAT TCA CCC CAA GAT TTA TCC AAT GAA GAA 99Ser Lys Lys Ala Gln Gln Asp Ser Pro Gln Asp Leu Ser Asn Glu Glu
15 20 25GCA ACA GAA GCC AAT CAT TTT GAA AAT CTT TTA AAA GAA TCC AAA GAA 147Ala Thr Glu Ala Asn His Phe Glu Asn Leu Leu Lys Glu Ser Lys Glu
30 35 40AGC TCA GAT CAT CAT CTT GAC AAC CCC ACA GAA ACT CAA ACC CAT TTT 195Ser Ser Asp His His Leu Asp Asn Pro Thr Glu ThrGln Thr His Phe
45 50 55GAT GGA GAC AAG TCA GAA GAA ACC CAA ACT CAA ATG GAT TCT GAA GGT 243Asp Gly Asp Lys Ser Glu Glu Thr Gln Thr Gln Met Asp Ser Glu Gly
60 65 70AAT GAA ACT TCA GAA TCT AGC AAT GGC AGT CTA GCA GAC AAG TTA TTC 291Asn Glu Thr Ser Glu Ser Ser Asn Gly Ser Leu Ala Asp Lys Leu Phe75 80 85 90AAA AAA GCC AGA AAA TTA GTT GAT AAT AAA AAA CCT TTC ACT CAG CAA 339Lys Lys Ala Arg Lys Leu Val Asp Asn Lys Lys Pro Phe Thr Gln Gln
95 100 105AAG AAT TTA GAT GAA GAA ACC CAA GAA CTG AAC GAA GAA GAC GAT CAA 387Lys Asn Leu Asp Glu Glu Thr Gln Glu Leu Asn Glu Glu Asp Asp Gln
110 115 120GAA AAT AAT GAG TAT CAA GAA GAA ACT CAA ACG GAC TTA ATT GAT GAT 435Glu Asn Asn Glu Tyr Gln Glu Glu Thr Gln Thr Asp Leu Ile Asp Asp
125 130 135GAA ACT TCT AAA AAA ACC CAA CAA CAT TCA CCC CAA GAT TTA TCC AAT 483Glu Thr Ser Lys Lys Thr Gln Gln His Ser Pro Gln Asp Leu Ser Asn
140 145 150GAA GAA GCA ACA GAA GCC AAT CAT TTT GAA AAT CTT TTA AAA GAA TCC 531Glu Glu Ala Thr Glu Ala Asn His Phe Glu Asn Leu Leu Lys Glu Ser155 160 165 170AAA GAA AGC TCA GAT CAT CAT CTT GAC AAC CCC ACA GAA ACT CAA ACC 579Lys Glu Ser Ser Asp His His Leu Asp Asn Pro Thr Glu Thr Gln Thr
175 180 185AAT TTT GAT GGA GAC AAG TCA GAA GAA ACC CAA ACT CAA ATG GAT TCT 627Asn Phe Asp Gly Asp Lys Ser Glu Glu Thr Gln Thr Gln Met Asp Ser
190 195 200GAA GGTAAT GAA ACT TCA GAA TCT AGC AAT GGC AGT CTA GCA GAC AAG 675Glu Gly Asn Glu Thr Ser Glu Ser Ser Asn Gly Ser Leu Ala Asp Lys
205 210 215TTA TTC AAA AAA GCC AGA AAA TTA GTT GAT AAT AAA AAA CCT TTC ACT 723Leu Phe Lys Lys Ala Arg Lys Leu Val Asp Asn Lys Lys Pro Phe Thr
220 225 230CAG CAA AAG AAT TTA GAT GAA GAA ACC CAA GAA CTG AAC GAA GAA GAC 771Gln Gln Lys Asn Leu Asp Glu Glu Thr Gln Glu Leu Asn Glu Glu Asp235 240 245 250GAT CAA GAA AAT AAT GAG TAT CAA GAA GAA ACT CAA ACG GAC TTA ATT 819Asp Gln Glu Asn Asn Glu Tyr Gln Glu Glu Thr Gln Thr Asp Leu Ile
255 260 265GAT GAT GAA ACT TCT AAA AAA ACC CAA CAA CAT TCA CCC CAA GAT TTA 867Asp Asp Glu Thr Ser Lys Lys Thr Gln Gln His Ser Pro Gln Asp Leu
270 275 280TCC AAT GAA GAA GCA ACA GAA GCC AAT CAT TTT GAA AAT CTT TTA AAA 915Ser Asn Glu Glu Ala Thr Glu Ala Asn His Phe Glu Asn Leu Leu Lys
285 290 295GAA TCC AAA GAA AGC TCA GAT CAT CAT CTT GAC AAC CCC ACA GAA ACT 963Glu Ser Lys Glu Ser Ser Asp His His Leu Asp Asn Pro Thr Glu Thr
300 305 310CAA ACC AAT TTT GAT GGA GAC AAG TCA GAA GAA ATA ACT GAC GAC TCT 1011Gln Thr Asn Phe Asp Gly Asp Lys Ser Glu Glu Ile Thr Asp Asp Ser315 320 325 330AAC GAT CAA GAG ATT ATC AAA GGA AGC AAA AAG AAA TAT ATT ATT GGT 1059Asn Asp Gln Glu Ile Ile Lys Gly Ser Lys Lys Lys Tyr Ile Ile Gly
335 340 345GGC ATT GTA GTC GCT GTT CTT ATC GTG ATT ATT TTA TTT TCT AGA AGC 1107Gly Ile ValVal Ala Val Leu Ile Val Ile Ile Leu Phe Ser Arg Ser
350 355 360ATT TTT CAC TAC TTC ATG CCT TTG GAA GAT AAA AGC TCT CGT TTT AGC 1155Ile Phe His Tyr Phe Met Pro Leu Glu Asp Lys Ser Ser Arg Phe Ser
365 370 375AAA GAC AGG AAT CTT TAT GTC AAT GAT GAA ATC CAA ATA AGG CAA GAG 1203Lys Asp Arg Asn Leu Tyr Val Asn Asp Glu Ile Gln Ile Arg Gln Glu
380 385 390TAT AAC CGA TTG CTG AAA GAA CGG AAT GAA AAA GGC AAT ATG ATC GAT 1251Tyr Asn Arg Leu Leu Lys Glu Arg Asn Glu Lys Gly Asn Met Ile Asp395 400 405 410AAG AAT CTT TTC TTC AAT GAC GAT CCC AAT AGA ACC TTA TAC AAC TAT 1299Lys Asn Leu Phe Phe Asn Asp Asp Pro Asn Arg Thr Leu Tyr Asn Tyr
415 420 425TTG AAT ATT GCA GAA ATT GAG GAC AAA AAC CCG TTG AGA GCC TTT TAT 1347Leu Asn Ile Ala Glu Ile Glu Asp Lys Asn Pro Leu Arg Ala Phe Tyr
430 435 440GAA TGT ATT AGT AAT GGT GGC AAC TAT GAA GAA TGT TTG AAG CTT ATC 1395Glu Cys Ile Ser Asn Gly Gly Asn Tyr Glu Glu Cys Leu Lys Leu Ile
445 450 455AAA GAC AAA AAA CTT CAA GAT CAG ATG AAA AAG ACT CTA GAG GCT TAT 1443Lys Asp Lys Lys Leu Gln Asp Gln Met Lys Lys Thr Leu Glu Ala Tyr
460 465 470AAC GAC TGC ATC AAA AAT GCC AAA ACT GAA GAA GAA AGG ATC AAG TGT 1491Asn Asp Cys Ile Lys Asn Ala Lys Thr Glu Glu Glu Arg Ile Lys Cys475 480 485 490TTA GAT TTA ATC AAA GAT GAA AAC CTA AAA AAA AGC TTA CTG AAC CAA 1539Leu Asp Leu Ile Lys Asp Glu Asn Leu Lys Lys Ser Leu Leu Asn Gln
495 500 505CAA AAA GTT CAA GTG GCG CTA GAT TGT TTG AAA AAC GCT AAA ACC GAT 1587Gln Lys Val Gln Val Ala Leu Asp Cys Leu Lys Asn Ala Lys Thr Asp
510 515 520GAA GAA CGA AAC GAG TGC CTA AAA CTC ATA AAT GAC CCT GAG ATT AGA 1635Glu Glu Arg Asn Glu Cys Leu Lys Leu Ile Asn Asp Pro Glu Ile Arg
525 530 535GAG AAA TTC CGT AAG GAA TTA GAG CTT CAA AAA GAG CTT CAA GAG TAT 1683Glu Lys Phe Arg Lys Glu Leu Glu Leu Gln Lys Glu Leu Gln Glu Tyr
540 545 550AAG GAT TGT ATC AAA AAC GCC AAA ACA GAA GCT GAG AAA AAC AAA TGC 1731Lys Asp Cys Ile Lys Asn Ala Lys Thr Glu Ala Glu Lys Asn Lys Cys555 560 565 570TTG AAA GGC TTG TCT AAA GAA GCT ATA GAG AGA TTG AAA CAG CAA GCG 1779Leu Lys Gly Leu Ser Lys Glu Ala Ile Glu Arg Leu Lys Gln Gln Ala
575 580 585CTA GAT TGT TTG AAA AAC GCT AAA ACC GAT GAA GAA CGA AAC GAG TGC 1827Leu Asp Cys Leu Lys Asn Ala Lys Thr Asp Glu Glu Arg Asn Glu Cys
590 595 600TTG AAA AAT ATT CCC CAA GAC TTG CAA AAA GAA CTA TTA GCT GAT ATG 1875Leu Lys Asn Ile Pro Gln Asp Leu Gln Lys Glu Leu Leu Ala Asp Met
605 610 615AGC GTC AAG GCT TAC AAG GAT TGC GTA TCA AAA GCT AGA AAT GAA AAA 1923Ser Val Lys Ala Tyr Lys Asp Cys Val Ser Lys Ala Arg Asn Glu Lys
620 625 630GAG AAA CAA GAA TGC GAG AAA TTG CTC ACG CCT GAA GCG AGG AAA AAG 1971Glu Lys Gln Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Lys635 640 645 650TTA GAA CAA CAG GTTCTA GAT TGT TTG AAA AAC GCT AAA ACC GAT GAA 2019Leu Glu Gln Gln Val Leu Asp Cys Leu Lys Asn Ala Lys Thr Asp Glu
655 660 665GAA CGA AAA AAG TGT TTG AAA GAT CTC CCT AAA GAC TTA CAA AGC GAT 2067Glu Arg Lys Lys Cys Leu Lys Asp Leu Pro Lys Asp Leu Gln Ser Asp
670 675 680ATT CTA GCC AAA GAG AGC CTG AAA GCT TAT AAA GAC TGC GTA TCT CAA 2115Ile Leu Ala Lys Glu Ser Leu Lys Ala Tyr Lys Asp Cys Val Ser Gln
685 690 695GCC AAA ACC GAA GCT GAG AAA AAA GAA TGC GAG AAA TTA CTC ACC CCT 2163Ala Lys Thr Glu Ala Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro
700 705 710GAA GCG AAA AAA CTT TTA GAA GAA GAA GCC AAA GAG AGC GTT AAG GCT 2211Glu Ala Lys Lys Leu Leu Glu Glu Glu Ala Lys Glu Ser Val Lys Ala715 720 725 730TAT TTG GAT TGC GTA TCT CAA GCC AAA ACC GAA GCT GAG AAA AAA GAA 2259Tyr Leu Asp Cys Val Ser Gln Ala Lys Thr Glu Ala Glu Lys Lys Glu
735 740 745TGC GAG AAA TTG CTC ACC CCT GAA GCG AAA AAA AAG TTA GAA GAA GCT 2307Cys Glu Lys Leu Leu Thr Pro Glu Ala Lys Lys Lys Leu Glu Glu Ala
750 755 760AAA AAA AGC GTT AAA GCT TAC TTG GAT TGC GTA TCA AGA GCT AGG AAT 2355Lys Lys Ser Val Lys Ala Tyr Leu Asp Cys Val Ser Arg Ala Arg Asn
765 770 775GAA AAA GAG AAA AAA GAA TGC GAG AAA TTG CTC ACC CCT GAA GCG AAA 2403Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Lys
780 785 790AAA CTT TTA GAG CAA CAA GCA CTA GAT TGT TTG AAA AAC GCT AAA ACC 2451Lys Leu Leu Glu Gln Gln Ala Leu Asp Cys Leu Lys Asn Ala Lys Thr795 800 805 810GAT AAA GAA CGA AAA AAG TGT TTG AAA GAT CTC CCT AAA GAC TTG CAG 2499Asp Lys Glu Arg Lys Lys Cys Leu Lys Asp Leu Pro Lys Asp Leu Gln
815 820 825AAA AAG GTT TTA GCT AAA GAA AGC GTT AAA GCT TAC TTG GAT TGC GTA 2547Lys Lys Val Leu Ala Lys Glu Ser Val Lys Ala Tyr Leu Asp Cys Val
830 835 840TCT CAA GCC AAA ACT GAA GCT GAG AAA AAA GAA TGC GAG AAA TTA CTC 2595Ser Gln Ala Lys Thr Glu Ala Glu Lys Lys Glu Cys Glu Lys Leu Leu
845 850 855ACC CCT GAA GCG AGA AAA CTT TTA GAA GAA GCT AAA AAA AGC GTT AAG 2643Thr Pro Glu Ala Arg Lys Leu Leu Glu Glu Ala Lys Lys Ser Val Lys
860 865 870GCT TAY TTG GAT TGC GTA TCT CAA GCC AAA ACT GAA GCT GAG AAA AAA 2691Ala Xaa Leu Asp Cys Val Ser Gln Ala Lys Thr Glu Ala Glu Lys Lys875 880 885 890GAA TGC GAG AAA TTA CTC ACC CCT GAA GCG AGA AAA CTC TTA GAA GAA 2739Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu Glu
895 900 905GCT AAA GAG AGC GTT AAA GCT TAT AAA GAC TGC GTA TCA AAA GCT AGG 2787Ala Lys Glu Ser Val Lys Ala Tyr Lys Asp Cys Val Ser Lys Ala Arg
910 915 920 AAT GAA AAA GAG AAA AAA GAA TGC GAG AAA TTA CTC ACG CCT GAA GCG 2835 Asn Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala
925 930 935 AAA AAA CTT TTA GAG CAA CAA GTG CTA GAT TGT TTG AAA AAC GCT AAA 2883 Lys Lys Leu Leu Glu Gln Gln Val Leu Asp Cys Leu Lys Asn AlaLys
940 945 950 ACC GAA GCT GAT AAA AAA AGG TGT GTC AAA GAT CTC CCT AAA GAC TTG 2931 Thr Glu Ala Asp Lys Lys Arg Cys Val Lys Asp Leu Pro Lys Asp Leu 955 960 965 970 CAG AAA AAG GTT TTA GCT AAA GAG AGC GTT AAG GCT TAT TTG GAC TGC 2979 Gln Lys Lys Val Leu Ala Lys Glu Ser Val Lys Ala Tyr Leu Asp Cys
975 980 985 GTA TCA AGA GCT AGG AAT GAA AAA GAG AAA AAA GAA TGC GAG AAA TTG 3027 Val Ser Arg Ala Arg Asn Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu
990 995 1000 CTC ACC CCT GAA GCG AAA AAA CTT TTA GAA GAA GCC AAA GAG AGT CTT 3075 Leu Thr Pro Glu Ala Lys Lys Leu Leu Glu Glu Ala Lys Glu Ser Leu
1005 1010 1015 AAA GCT TAT AAA GAC TGC CTC TCT CAA GCT AGA AAT GAA GAA GAA AGG 3123 Lys Ala Tyr Lys Asp Cys Leu Ser Gln Ala Arg Asn Glu Glu Glu Arg
1020 1025 1030 AGA GCT TGC GAG AAA CTA CTC ACG CCT GAA GCG AGA AAA CTC TTA GAG 3171 Arg Ala Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu1035 1040 1045 1050 CAA GAA GTT AAG AAA AGC ATT AAG GCT TAT TTG GAC TGC GTA TCA AGA 3219 Gln Glu Val Lys Lys Ser Ile Lys Ala Tyr Leu Asp Cys Val Ser Arg
1055 1060 1065 GCT AGG AAT GAA AAA GAG AAA AAA GAA TGC GAG AAA TTA CTC ACG CCT 3267 Ala Arg Asn Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro
1070 1075 1080 GAA GCG AGA AAA TTT TTA GCG AAG CAA GTG CTA AAT TGT TTG GAA AAA 3315 Glu Ala Arg Lys Phe Leu Ala Lys Gln Val Leu Asn Cys Leu Glu Lys
1085 1090 1095 GCT GGA AAT GAA GAA GAA AGA AAA GCA TGT CTT AAA AAT CTC CCT AAA 3363 Ala Gly Asn Glu Glu Glu Arg Lys Ala Cys Leu Lys Asn Leu Pro Lys
1100 1105 1110 GAC TTA CAG GAA AAT ATT TTA GCT AAA GAG AGT CTT AAA GCT TAT AAA 3411 Asp Leu Gln Glu Asn Ile Leu Ala Lys Glu Ser Leu Lys Ala Tyr Lys1115 1120 1125 1130 GAC TGC CTC TCT CAA GCT AGA AAT GAA GAA GAA AGG AGA GCT TGC GAG 3459 Asp Cys Leu Ser Gln Ala Arg Asn Glu Glu Glu Arg Arg Ala Cys Glu
1135 1140 1145 AAA CTA CTC ACG CCT GAA GCG AGA AAA CTC TTA GAG CAA GAA GTT AAG 3507 Lys Leu Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu Gln Glu Val Lys
1150 1155 1160 AAA AGC GTT AAG GCT TAT TTG GAC TGC GTA TCA AGA GCT AGG AAT GAA 3555 Lys Ser Val Lys Ala Tyr Leu Asp Cys Val Ser Arg Ala Arg Asn Glu
1165 1170 1175 AAA GAG AAA AAA GAA TGC GAG AAA TTA CTC ACG CCT GAA GCG AGA AAA 3603 Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys
1180 1185 1190 TTT TTA GCG AAA GAA CTC CAA CAA AAA GAT AAA GCG ATC AAA GAT TGC 3651 Phe Leu Ala Lys Glu Leu Gln Gln Lys Asp Lys Ala Ile Lys Asp Cys1195 1200 1205 1210 TTG AAA AAC GCC GAT CCT AAC GAC AGA GCG GCT ATC ATG AAG TGT TTG 3699 Leu Lys Asn Ala Asp Pro Asn Asp Arg Ala Ala Ile Met Lys Cys Leu
1215 1220 1225 GAT GGT TTG AGC GAT GAA GAG AAG CTC AAA TAC CTG CAA GAA GCT AGA 3747 Asp Gly Leu Ser Asp Glu Glu Lys Leu Lys Tyr Leu Gln Glu Ala Arg
1230 1235 1240 GAA AAG GCT GTT GCG GAT TGT TTGGCT ATG GCT AAA ACC GAT GAA GAA 3795 Glu Lys Ala Val Ala Asp Cys Leu Ala Met Ala Lys Thr Asp Glu Glu
1245 1250 1255 AAA AGG AAA TGC CAA AAC CTT TAT AGC GAT TTG ATC CAA GAA ATC CAA 3843 Lys Arg Lys Cys Gln Asn Leu Tyr Ser Asp Leu Ile Gln Glu Ile Gln
1260 1265 1270 AAT AAA AGG ACA CAA AAC AAA CAA AAT CAA TTG AGT AAA ACA GAA AGG 3891 Asn Lys Arg Thr Gln Asn Lys Gln Asn Gln Leu Ser Lys Thr Glu Arg1275 1280 1285 1290 TTG CAT CAA GCA AGC GAG TGC TTG GAT AAC TTA GAT GAC CCT ACT GAT 3939 Leu His Gln Ala Ser Glu Cys Leu Asp Asn Leu Asp Asp Pro Thr Asp
1295 1300 1305 CAA GAG GCC ATA GAG CAA TGT TTA GAG GGC TTG AGC GAT AGT GAA AGG 3987 Gln Glu Ala Ile Glu Gln Cys Leu Glu Gly Leu Ser Asp Ser Glu Arg
1310 1315 1320 GCG CTA ATT CTA GGA ATT AAA CGA CAA GCT GAT GAA GTG GAT CTG ATT 4035 Ala Leu Ile Leu Gly Ile Lys Arg Gln Ala Asp Glu Val Asp Leu Ile
1325 1330 1335 TAT AGC GAT CTA AGA AAC CGT AAA ACC TTT GAT AAC ATG GCG GCT AAA 4083 Tyr Ser Asp Leu Arg Asn Arg Lys Thr Phe Asp Asn Met Ala Ala Lys
1340 1345 1350 GGT TAT CCA TTG TTA CCA ATG GAT TTC AAA AAT GGC GGC GAT ATT GCC 4131 Gly Tyr Pro Leu Leu Pro Met Asp Phe Lys Asn Gly Gly Asp Ile Ala1355 1360 1365 1370 ACT ATT AAC GCC ACT AAT GTT GAT GCG GAC AAA ATA GCT AGC GAT AAT 4179 Thr Ile Asn Ala Thr Asn Val Asp Ala Asp Lys Ile Ala Ser Asp Asn
1375 1380 1385 CCT ATT TAT GCT TCC ATA GAG CCT GAT ATT GCC AAG CAA TAC GAA ACA 4227 Pro IleTyr Ala Ser Ile Glu Pro Asp Ile Ala Lys Gln Tyr Glu Thr
1390 1395 1400 GAA AAA ACC ATT AAG GAT AAG AAT TTA GAA GCT AAA TTA GCT AAG GCT 4275 Glu Lys Thr Ile Lys Asp Lys Asn Leu Glu Ala Lys Leu Ala Lys Ala
1405 1410 1415 TTA GGT GGC AAT AAA AAA GAT GAC GAT AAA GAA AAA AGT AAA AAA TCC 4323 Leu Gly Gly Asn Lys Lys Asp Asp Asp Lys Glu Lys Ser Lys Lys Ser
1420 1425 1430 ACA GCA GAA GCT AAA GCA GAA AAC AAT AAG ATA GAC AAA GAT GTC GCA 4371 Thr Ala Glu Ala Lys Ala Glu Asn Asn Lys Ile Asp Lys Asp Val Ala1435 1440 1445 1450 GAA ACT GCC AAG AAT ATC AGT GAA ATC GCT CTT AAG AAC AAA AAA GAA 4419 Glu Thr Ala Lys Asn Ile Ser Glu Ile Ala Leu Lys Asn Lys Lys Glu
1455 1460 1465 AAG AGT GGG GAA TTT GTA GAT GAA AAT GGT AAT CCC ATT GAT GAC AAA 4467 Lys Ser Gly Glu Phe Val Asp Glu Asn Gly Asn Pro Ile Asp Asp Lys
1470 1475 1480 AAG AAA GCA GAA AAA CAA GAT GAA ACA AGC CCT GTC AAA CAG GCC TTT 4515 Lys Lys Ala Glu Lys Gln Asp Glu Thr Ser Pro Val Lys Gln Ala Phe
1485 1490 1495 ATA GGC AAG AGT GAT CCC ACA TTT GTT TTA GCG CAA TAC ACC CCC ATT 4563 Ile Gly Lys Ser Asp Pro Thr Phe Val Leu Ala Gln Tyr Thr Pro Ile
1500 1505 1510 GAA ATC ACT CTG ACT TCT AAA GTA GAT GCC ACT CTC ACA GGT ATA GTG 4611 Glu Ile Thr Leu Thr Ser Lys Val Asp Ala Thr Leu Thr Gly Ile Val1515 1520 1525 1530 AGT GGG GTT GTA GCC AAA GAT GTA TGG AAC ATG AAC GGC ACT ATG ATC 4659 Ser Gly Val Val Ala Lys Asp Val Trp Asn Met Asn Gly Thr Met Ile
1535 1540 1545 TTA TTA GAC AAA GGC ACT AAG GTG TAT GGG AAT TAT CAA AGC GTG AAA 4707 Leu Leu Asp Lys Gly Thr Lys Val Tyr Gly Asn Tyr Gln Ser Val Lys
1550 1555 1560 GGT GGC ACA CCC ATT ATG ACA CGC TTA ATG ATA GTC TTT ACT AAA GCC 4755 Gly Gly Thr Pro Ile Met Thr Arg Leu Met Ile Val Phe Thr Lys Ala
1565 1570 1575 ATT ACG CCT GAT GGT GTG ATA ATA CCT CTA GCA AAC GCT CAA GCA GCA 4803 Ile Thr Pro Asp Gly Val Ile Ile Pro Leu Ala Asn Ala Gln Ala Ala
1580 1585 1590 GGC ATG TTG GGT GAA GCA GGG GTA GAT GGC TAT GTG AAT AAT CAC TTT 4851 Gly Met Leu Gly Glu Ala Gly Val Asp Gly Tyr Val Asn Asn His Phe1595 1600 1605 1610 ATG AAG CGC ATA GGC TTT GCT GTG ATA GCA AGC GTG GTT AAT AGC TTC 4899 Met Lys Arg Ile Gly Phe Ala Val Ile Ala Ser Val Val Asn Ser Phe
1615 1620 1625 TTG CAA ACT GCG CCT ATC ATA GCT CTA GAT AAA CTC ATA GGC CTT GGC 4947 Leu Gln Thr Ala Pro Ile Ile Ala Leu Asp Lys Leu Ile Gly Leu Gly
1630 1635 1640 AAA GGT AGA AGT GAA AGG ACA CCT GAA TTT AAT TAC GCT TTG GGT CAA 4995 Lys Gly Arg Ser Glu Arg Thr Pro Glu Phe Asn Tyr Ala Leu Gly Gln
1645 1650 1655 GCT ATC AAT GGT AGC ATG CAA AGT TCA GCT CAG ATG TCT AAT CAA ATT 5043 Ala Ile Asn Gly Ser Met Gln Ser Ser Ala Gln Met Ser Asn Gln Ile
1660 1665 1670 CTA GGG CAA CTG ATG AAT ATC CCC CCA AGT TTT TAC AAA AAC GAG GGC 5091 Leu Gly Gln Leu Met Asn Ile Pro Pro Ser Phe Tyr Lys Asn Glu Gly1675 16801685 1690 GAT AGT ATT AAG ATT CTC ACA ATG GAC GAT ATT GAT TTT AGC GGT GTG 5139 Asp Ser Ile Lys Ile Leu Thr Met Asp Asp Ile Asp Phe Ser Gly Val
1695 1700 1705 TAT GAT GTT AAA ATT ACT AAC AAA TCT GTG GTA GAT GAA ATT ATC AAA 5187 Tyr Asp Val Lys Ile Thr Asn Lys Ser Val Val Asp Glu Ile Ile Lys
1710 1715 1720 CAA AGC ACC AAA ACT TTG TCT AGA GAA CAT GAA GAA ATC ACC ACA AGC 5235 Gln Ser Thr Lys Thr Leu Ser Arg Glu His Glu Glu Ile Thr Thr Ser
1725 1730 1735 CCC AAA GGT GGC AAT TAATTCAAGA GAAAGGATAA AATATATTCA TGTTACTAAA C 5291 Pro Lys Gly Gly Asn
1740 TCGGTTCTTT ACAAAATAAA AGACAAAACC AACAACAGGC TCT 5334 (2) sequence 1358 data: (i) sequence characteristics: length (A): 1743 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1358: met Asn Glu Glu Asn Asp Lys Leu Glu Thr Ser Lys Lys Ala Gln Gln 151015 Asp Ser Pro Gln Asp Leu Ser Asn Glu Glu Ala Thr Glu Ala Asn His
20 25 30Phe Glu Asn Leu Leu Lys Glu Ser Lys Glu Ser Ser Asp His His Leu
35 40 45Asp Asn Pro Thr Glu Thr Gln Thr His Phe Asp Gly Asp Lys Ser Glu
50 55 60Glu Thr Gln Thr Gln Met Asp Ser Glu Gly Asn Glu Thr Ser Glu Ser65 70 75 80Ser Asn Gly Ser Leu Ala Asp Lys Leu Phe Lys Lys Ala Arg Lys Leu
85 90 95Val Asp Asn Lys Lys Pro Phe Thr Gln Gln Lys Asn Leu Asp Glu Glu
100 105 110Thr Gln Glu Leu Asn Glu Glu Asp Asp Gln Glu Asn Asn Glu Tyr Gln
115 120 125Glu Glu Thr Gln Thr Asp Leu Ile Asp Asp Glu Thr Ser Lys Lys Thr
130 135 140Gln Gln His Ser Pro Gln Asp Leu Ser Asn Glu Glu Ala Thr Glu Ala145 150 155 160Asn His Phe Glu Asn Leu Leu Lys Glu Ser Lys Glu Ser Ser Asp His
165 170 175His Leu Asp Asn Pro Thr Glu Thr Gln Thr Asn Phe Asp Gly Asp Lys
180 185 190Ser Glu Glu Thr Gln Thr Gln Met Asp Ser Glu Gly Asn Glu Thr Ser
195 200 205Glu Ser Ser Asn Gly Ser Leu Ala Asp Lys Leu Phe Lys Lys Ala Arg
210 215 220Lys Leu Val Asp Asn Lys Lys Pro Phe Thr Gln Gln Lys Asn Leu Asp225 230 235 240Glu Glu Thr Gln Glu Leu Asn Glu Glu Asp Asp Gln Glu Asn Asn Glu
245 250 255Tyr Gln Glu Glu Thr Gln Thr Asp Leu Ile Asp Asp Glu Thr Ser Lys
260 265 270Lys Thr Gln Gln His Ser Pro Gln Asp Leu Ser Asn Glu Glu Ala Thr
275 280 285Glu Ala Asn His Phe Glu Asn Leu Leu Lys Glu Ser Lys Glu Ser Ser
290 295 300Asp His His Leu Asp Asn Pro Thr Glu Thr Gln Thr Asn Phe Asp Gly305 310 315 320Asp Lys Ser Glu Glu Ile Thr Asp Asp Ser Asn Asp Gln Glu Ile Ile
325 330 335Lys Gly Ser Lys Lys Lys Tyr Ile Ile Gly Gly Ile Val Val Ala Val
340 345 350Leu Ile Val Ile Ile Leu Phe Ser Arg Ser Ile Phe His Tyr Phe Met
355 360 365Pro Leu Glu Asp Lys Ser Ser Arg Phe Ser Lys Asp Arg Asn Leu Tyr
370 375 380Val Asn Asp Glu Ile Gln Ile Arg Gln Glu Tyr Asn Arg Leu Leu Lys385 390 395 400Glu Arg Asn Glu Lys Gly Asn Met Ile Asp Lys Asn Leu Phe Phe Asn
405 410 415Asp Asp Pro Asn Arg Thr Leu Tyr Asn Tyr Leu Asn Ile Ala Glu Ile
420 425 430Glu Asp Lys Asn Pro Leu Arg Ala Phe Tyr Glu Cys Ile Ser Asn Gly
435 440 445Gly Asn Tyr Glu Glu Cys Leu Lys Leu Ile Lys Asp Lys Lys Leu Gln
450 455 460Asp Gln Met Lys Lys Thr Leu Glu Ala Tyr Asn Asp Cys Ile Lys Asn465 470 475 480Ala Lys Thr Glu Glu Glu Arg Ile Lys Cys Leu Asp Leu Ile Lys Asp
485 490 495Glu Asn Leu Lys Lys Ser Leu Leu Asn Gln Gln Lys Val Gln ValAla
500 505 510Leu Asp Cys Leu Lys Asn Ala Lys Thr Asp Glu Glu Arg Asn Glu Cys
515 520 525Leu Lys Leu Ile Asn Asp Pro Glu Ile Arg Glu Lys Phe Arg Lys Glu
530 535 540Leu Glu Leu Gln Lys Glu Leu Gln Glu Tyr Lys Asp Cys Ile Lys Asn545 550 555 560Ala Lys Thr Glu Ala Glu Lys Asn Lys Cys Leu Lys Gly Leu Ser Lys
565 570 575Glu Ala Ile Glu Arg Leu Lys Gln Gln Ala Leu Asp Cys Leu Lys Asn
580 585 590Ala Lys Thr Asp Glu Glu Arg Asn Glu Cys Leu Lys Asn Ile Pro Gln
595 600 605Asp Leu Gln Lys Glu Leu Leu Ala Asp Met Ser Val Lys Ala Tyr Lys
610 615 620Asp Cys Val Ser Lys Ala Arg Asn Glu Lys Glu Lys Gln Glu Cys Glu625 630 635 640Lys Leu Leu Thr Pro Glu Ala Arg Lys Lys Leu Glu Gln Gln Val Leu
645 650 655Asp Cys Leu Lys Asn Ala Lys Thr Asp Glu Glu Arg Lys Lys Cys Leu
660 665 670Lys Asp Leu Pro Lys Asp Leu Gln Ser Asp Ile Leu Ala Lys Glu Ser
675 680 685Leu Lys Ala Tyr Lys Asp Cys Val Ser Gln Ala Lys Thr Glu Ala Glu
690 695 700Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Lys Lys Leu Leu705 710 715 720Glu Glu Glu Ala Lys Glu Ser Val Lys Ala Tyr Leu Asp Cys Val Ser
725 730 735Gln Ala Lys Thr Glu Ala Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr
740 745 750Pro Glu Ala Lys Lys Lys Leu Glu Glu Ala Lys Lys Ser Val Lys Ala
755 760 765Tyr Leu Asp Cys Val Ser Arg Ala Arg Asn Glu Lys Glu Lys Lys Glu
770 775 780Cys Glu Lys Leu Leu Thr Pro Glu Ala Lys Lys Leu Leu Glu Gln Gln785 790 795 800Ala Leu Asp Cys Leu Lys Asn Ala Lys Thr Asp Lys Glu Arg Lys Lys
805 810 815Cys Leu Lys Asp Leu Pro Lys Asp Leu Gln Lys Lys Val Leu Ala Lys
820 825 830Glu Ser Val Lys Ala Tyr Leu Asp Cys Val Ser Gln Ala Lys Thr Glu
835 840 845Ala Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys
850 855 860Leu Leu Glu Glu Ala Lys Lys Ser Val Lys Ala Xaa Leu Asp Cys Val865 870 875 880Ser Gln Ala Lys Thr Glu Ala Glu Lys Lys Glu Cys Glu Lys Leu Leu
885 890 895Thr Pro Glu Ala Arg Lys Leu Leu Glu Glu Ala Lys Glu Ser Val Lys
900 905 910Ala Tyr Lys Asp Cys Val Ser Lys Ala Arg Asn Glu Lys Glu Lys Lys
915 920 925Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Lys Lys Leu Leu Glu Gln
930 935 940Gln Val Leu Asp Cys Leu Lys Asn Ala Lys Thr Glu Ala Asp Lys Lys945 950 955 960Arg Cys Val Lys Asp Leu Pro Lys Asp Leu Gln Lys Lys Val Leu Ala
965 970 975Lys Glu Ser Val Lys Ala Tyr Leu Asp Cys Val Ser Arg Ala Arg Asn
980 985 990Glu Lys Glu Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Lys
995 1000 1005Lys Leu Leu Glu Glu Ala Lys Glu Ser Leu Lys Ala Tyr Lys Asp Cys 1010 1015 1020Leu Ser Gln Ala Arg Asn Glu Glu Glu Arg Arg Ala Cys Glu Lys Leu025 1030 1035 1040Leu Thr Pro Glu Ala Arg Lys Leu Leu Glu Gln Glu Val Lys Lys Ser
1045 1050 1055Ile Lys Ala Tyr Leu Asp Cys Val Ser Arg Ala Arg Asn Glu Lys Glu
1060 1065 1070Lys Lys Glu Cys Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Phe Leu
1075 1080 1085Ala Lys Gln Val Leu Asn Cys Leu Glu Lys Ala Gly Asn Glu Glu Glu 1090 1095 1100Arg Lys Ala Cys Leu Lys Asn Leu Pro Lys Asp Leu Gln Glu Asn Ile105 1110 1115 1120Leu Ala Lys Glu Ser Leu Lys Ala Tyr Lys Asp Cys Leu Ser Gln Ala
1125 1130 1135Arg Asn Glu Glu Glu Arg Arg Ala Cys Glu Lys Leu Leu Thr Pro Glu
1140 1145 1150Ala Arg Lys Leu Leu Glu Gln Glu Val Lys Lys Ser Val Lys Ala Tyr
1155 1160 1165Leu Asp Cys Val Ser Arg Ala Arg Asn Glu Lys Glu Lys Lys Glu Cys 1170 1175 1180Glu Lys Leu Leu Thr Pro Glu Ala Arg Lys Phe Leu Ala Lys Glu Leu185 1190 1195 1200Gln Gln Lys Asp Lys Ala Ile Lys Asp Cys Leu Lys Asn Ala Asp Pro
1205 1210 1215Asn Asp Arg Ala Ala Ile Met Lys Cys Leu Asp Gly Leu Ser Asp Glu
1220 1225 1230Glu Lys Leu Lys Tyr Leu Gln Glu Ala Arg Glu Lys Ala Val Ala Asp
1235 1240 1245Cys Leu Ala Met Ala Lys Thr Asp Glu Glu Lys Arg Lys Cys Gln Asn 1250 1255 1260Leu Tyr Ser Asp Leu Ile Gln Glu Ile Gln Asn Lys Arg Thr Gln Asn265 1270 1275 1280Lys Gln Asn Gln Leu Ser Lys Thr Glu Arg Leu His Gln Ala Ser Glu
1285 1290 1295Cys Leu Asp Asn Leu Asp Asp Pro Thr Asp Gln Glu Ala Ile Glu Gln
1300 1305 1310Cys Leu Glu Gly Leu Ser Asp Ser Glu Arg Ala Leu Ile Leu Gly Ile
1315 1320 1325Lys Arg Gln Ala Asp Glu Val Asp Leu Ile Tyr Ser Asp Leu Arg Asn 1330 1335 1340Arg Lys Thr Phe Asp Asn Met Ala Ala Lys Gly Tyr Pro Leu Leu Pro345 1350 1355 1360Met Asp Phe Lys Asn Gly Gly Asp Ile Ala Thr Ile Asn Ala Thr Asn
1365 1370 1375Val Asp Ala Asp Lys Ile Ala Ser Asp Asn Pro Ile Tyr Ala Ser Ile
1380 1385 1390Glu Pro Asp Ile Ala Lys Gln Tyr Glu Thr Glu Lys Thr Ile Lys Asp
1395 1400 1405Lys Asn Leu Glu Ala Lys Leu Ala Lys Ala Leu Gly Gly Asn Lys Lys 1410 1415 1420Asp Asp Asp Lys Glu Lys Ser Lys Lys Ser Thr Ala Glu Ala Lys Ala425 1430 1435 1440Glu Asn Asn Lys Ile Asp Lys Asp Val Ala Glu Thr Ala Lys Asn Ile
1445 1450 1455Ser Glu Ile Ala Leu Lys Asn Lys Lys Glu Lys Ser Gly Glu Phe Val
1460 1465 1470Asp Glu Asn Gly Asn Pro Ile Asp Asp Lys Lys Lys Ala Glu Lys Gln
1475 1480 1485Asp Glu Thr Ser Pro Val Lys Gln Ala Phe Ile Gly Lys Ser Asp Pro 1490 1495 1500Thr Phe Val Leu Ala Gln Tyr Thr Pro Ile Glu Ile Thr Leu Thr Ser505 1510 1515 1520Lys Val Asp Ala Thr Leu Thr Gly Ile Val Ser Gly Val Val Ala Lys
1525 1530 1535Asp Val Trp Asn Met Asn Gly Thr Met Ile Leu Leu Asp Lys Gly Thr
1540 1545 1550Lys Val Tyr Gly Asn Tyr Gln Ser Val Lys Gly Gly Thr Pro Ile Met
1555 1560 1565Thr Arg Leu Met Ile Val Phe Thr Lys Ala Ile Thr Pro Asp Gly Val 1570 1575 1580Ile Ile Pro Leu Ala Asn Ala Gln Ala Ala Gly Met Leu Gly Glu Ala585 1590 1595 1600Gly Val Asp Gly Tyr Val Asn Asn His Phe Met Lys Arg Ile Gly Phe
1605 1610 1615Ala Val Ile Ala Ser Val Val Asn Ser Phe Leu Gln Thr Ala Pro Ile
1620 1625 1630Ile Ala Leu Asp Lys Leu Ile Gly Leu Gly Lys Gly Arg Ser Glu Arg
1635 1640 1645Thr Pro Glu Phe Asn Tyr Ala Leu Gly Gln Ala Ile Asn Gly Ser Met 1650 1655 1660Gln Ser Ser Ala Gln Met Ser Asn Gln Ile Leu Gly Gln Leu Met Asn665 1670 1675 1680Ile Pro Pro Ser Phe Tyr Lys Asn Glu Gly Asp Ser Ile Lys Ile Leu
1685 1690 1695Thr Met Asp Asp Ile Asp Phe Ser Gly Val Tyr Asp Val Lys Ile Thr
17001705 1710Asn Lys Ser Val Val Asp Glu Ile Ile Lys Gln Ser Thr Lys Thr Leu
171517201725 Ser Arg Glu His Glu Glu Ile Thr Thr Ser Pro Lys Gly Gly Asn 173017351740 (2) sequence 1359 data: (i) sequence characteristics: length (A): 877bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 825 (D) other information: (xi) Description of the sequence: sequence 1359: AACAAATAAA GGAGTATTAA A ATG AAA CAA AGT TTG CGC GAA CAA AAA TTA 51
Met Lys Gln Ser Leu Arg Glu Gln Lys Leu
1 5 10TTG AAA ATT TTA GAA AAT GAT GTC TTG ACG ATT TTG GAT AGT TTT TCT 99Leu Lys Ile Leu Glu Asn Asp Val Leu Thr Ile Leu Asp Ser Phe Ser
15 20 25AAT TAT CTT TTT GAA CTG AGA GAA GAG TTG GAC TTC ATA GAA GAA GAA 147Asn Tyr Leu Phe Glu Leu Arg Glu Glu Leu Asp Phe Ile Glu Glu Glu
30 35 40ATG GAA GGT GAA ATC ACC GAA CAA AAC CTT ACC GCT CTT TAT GAT TTT 195Met Glu Gly Glu Ile Thr Glu Gln Asn Leu Thr Ala Leu Tyr Asp Phe
45 50 55TCT AAT TTC TTA GAA GAC CAT GTC AAT GTA TTT TAT GAG AAT GTT TTG 243Ser Asn Phe Leu Glu Asp His Val Asn Val Phe Tyr Glu Asn Val Leu
60 65 70AAT ATA GAT GAT GTC AAA ACA GAA CAC CTT TAT TCA GGT CTC ATA GAT 291Asn Ile Asp Asp Val Lys Thr Glu His Leu Tyr Ser Gly Leu Ile Asp75 80 85 90AGT CTT AAC GCT AAT CTT CAC TTT GTC AAG TCA TTT CTC AGT AAT CAG 339Ser Leu Asn Ala Asn Leu His Phe Val Lys Ser Phe LeuSer Asn Gln
95 100 105GAT TTA GAC TTC CGC TTT TTT AAG GAA ATA AAC GAT GGG CAA GAT CCC 387Asp Leu Asp Phe Arg Phe Phe Lys Glu Ile Asn Asp Gly Gln Asp Pro
110 115 120CAA AAA ACA TTA TCA AGA TTA ATT CCT CTT CAA AGT GGG AAA AAT GAT 435Gln Lys Thr Leu Ser Arg Leu Ile Pro Leu Gln Ser Gly Lys Asn Asp
125 130 135GCA AGC TCG TTT AAA GCC AAT AAT TCT TTT GTT TCA TTA GTT TAT GTT 483Ala Ser Ser Phe Lys Ala Asn Asn Ser Phe Val Ser Leu Val Tyr Val
140 145 150TAT GTT TAC TTC ATG CTA GAA ACT ATC ATG CAG TCG TAT AGG ATT CTC 531Tyr Val Tyr Phe Met Leu Glu Thr Ile Met Gln Ser Tyr Arg Ile Leu155 160 165 170AGA TTG CTA GAA AAA CCT ATC AAT AAC AAC ATA AGC GAG GAC ATG CAG 579Arg Leu Leu Glu Lys Pro Ile Asn Asn Asn Ile Ser Glu Asp Met Gln
175 180 185AAC GAT ATA GAG AAT TTT TTT GTT CAA GCG AAT TTT TTA GAA TAC TAT 627Asn Asp Ile Glu Asn Phe Phe Val Gln Ala Asn Phe Leu Glu Tyr Tyr
190 195 200GTT CAG AAC AAA ATA TAC CCA ACC AAT CAT GCC TAT GAC TTC ACG CAT 675Val Gln Asn Lys Ile Tyr Pro Thr Asn His Ala Tyr Asp Phe Thr His
205 210 215TTG ATC ATG GAC TCC ATT ATT CCT AAT TGG ATT CAA ACT GAT ATG AGC 723Leu Ile Met Asp Ser Ile Ile Pro Asn Trp Ile Gln Thr Asp Met Ser
220 225 230GTT GAA GCT AAA AAG AAA GAG CTT TTT GAA AAA TAT TTT CAA AAC ATT 771Val Glu Ala Lys Lys Lys Glu Leu Phe Glu Lys Tyr Phe Gln Asn Ile235 240 245 250GAT GAA GTA ACA AAC AAA ATG CTC GAT CAA AAA ANT CAA AAC AAA AGT 819Asp Glu Val Thr Asn Lys Met Leu Asp Gln Lys Xaa Gln Asn Lys Ser
255 260 265AAC GAT TGAGTGGCGT TAATGCGCTA GAATAGTGCT AAAAATAAGA ATAAAGGAGT CA 877Asn Asp
877 (2) sequence 1360 data: (i) sequence characteristics: length (A): 268 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1360: met Lys Gln Ser Leu Arg Glu Gln Lys Leu Leu Lys Ile Leu Glu Asn 151015 Asp Val Leu Thr Ile Leu Asp Ser Phe Ser Asn Tyr Leu Phe Glu Leu
20 25 30Arg Glu Glu Leu Asp Phe Ile Glu Glu Glu Met Glu Gly Glu Ile Thr
35 40 45Glu Gln Asn Leu Thr Ala Leu Tyr Asp Phe Ser Asn Phe Leu Glu Asp
50 55 60His Val Asn Val Phe Tyr Glu Asn Val Leu Asn Ile Asp Asp Val Lys65 70 75 80Thr Glu His Leu Tyr Ser Gly Leu Ile Asp Ser Leu Asn Ala Asn Leu
85 90 95His Phe Val Lys Ser Phe Leu Ser Asn Gln Asp Leu Asp Phe Arg Phe
100 105 110Phe Lys Glu Ile Asn Asp Gly Gln Asp Pro Gln Lys Thr Leu Ser Arg
115 120 125Leu Ile Pro Leu Gln Ser Gly Lys Asn Asp Ala Ser Ser Phe Lys Ala
130 135 140Asn Asn Ser Phe Val Ser Leu Val Tyr Val Tyr Val Tyr Phe Met Leu145 150 155 160Glu Thr Ile Met Gln Ser Tyr Arg Ile Leu Arg Leu Leu Glu Lys Pro
165 170 175Ile Asn Asn Asn Ile Ser Glu Asp Met Gln Asn Asp Ile Glu Asn Phe
180 185 190Phe Val Gln Ala Asn Phe Leu Glu Tyr Tyr Val Gln Asn Lys Ile Tyr
195 200 205Pro Thr Asn His Ala Tyr Asp Phe Thr His Leu Ile Met Asp Ser Ile
210 215 220Ile Pro Asn Trp Ile Gln Thr Asp Met Ser Val Glu Ala Lys Lys Lys225 230 235 240Glu Leu Phe Glu Lys Tyr Phe Gln Asn Ile Asp Glu Val Thr Asn Lys
245 250 255Met Leu Asp Gln Lys Xaa Gln Asn Lys Ser Asn Asp
260265 (2) data of SEQ ID No. 1361: (i) sequence characteristics: length (A): 736bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 706 (D) other information: (xi) Description of the sequence: sequence 1361: AAAAAATCAA TAAAAGGGGT TTAGC ATG CAA GCA GTA ATT TAT GGC AAG CAA 52
Met Gln Ala Val Ile Tyr Gly Lys Gln
1 5GTG ATT ATG CAC CTT CTA AAC TCT CAT CAA GAA AAA TTG CAA GAA ATC 100Val Ile Met His Leu Leu Asn Ser His Gln Glu Lys Leu Gln Glu Ile10 15 20 25TAT CTT TCT AAA GAA ATA GAC AAG AAA CTT TTT TTC GCG CTC AAA AAA 148Tyr Leu Ser Lys Glu Ile Asp Lys Lys Leu Phe Phe Ala Leu Lys Lys
30 35 40GCA TGC CCT AAT ATC ATC AAA GTG GAT AAT AAA AAA GCG CAA AGC TTG 196Ala Cys Pro Asn Ile Ile Lys Val Asp Asn Lys Lys Ala Gln Ser Leu
45 50 55GCT AAG GGG GGG AAT CAT CAA GGG GTT TTG GCT AAG GTG GAA CTG CCC 244Ala Lys Gly Gly Asn His Gln Gly Val Leu Ala Lys Val Glu Leu Pro
60 65 70TTA GCG GTT TCT TTA AAA GAG GTT AAA AAA GCT CAA AAA CTT TTG GTG 292Leu Ala Val Ser Leu Lys Glu Val Lys Lys Ala Gln Lys Leu Leu Val
75 80 85CTT TGC GGG ATT ACG GAT GTG GGG AAT ATT GGA GGT ATT TTT AGG AGC 340Leu Cys Gly Ile Thr Asp Val Gly Asn Ile Gly Gly Ile Phe Arg Ser90 95 100 105GCG TAT TGC TTA GGA ATG GGT GGC GTT ATT TTA GAT TTT GCT AAA GAA 388Ala Tyr Cys Leu Gly Met Gly Gly Val Ile Leu Asp Phe Ala Lys Glu
110 115 120TTG GCT TAT GAG GGG ATT GTG CGA TCC AGC TTG GGG CTT ATG TAT GAT 436Leu Ala Tyr Glu Gly Ile Val Arg Ser Ser Leu Gly Leu Met Tyr Asp
125 130 135TTG CCT TTT AGC GTT ATG CCT AAC ACG CTG GAT TTA ATC AAT GAA TTG 484Leu Pro Phe Ser Val Met Pro Asn Thr Leu Asp Leu Ile Asn Glu Leu
140 145 150AAA ACG AGC GGG TTT TTA TGT TTG GGC GCG AGC ATG CAA GGC TCT AGT 532Lys Thr Ser Gly Phe Leu Cys Leu Gly Ala Ser Met Gln Gly Ser Ser
155 160 165CAA ATA GAA AAT CTA TCC TTA AAA AAA TGC GCT CTT TTT TTG GGG AGC 580Gln Ile Glu Asn Leu Ser Leu Lys Lys Cys Ala Leu Phe Leu Gly Ser170 175 180 185GAG CAT GAG GGG TTG TCT AAA AAA ATC CTT GCT AAA ATG GAT ACT ATA 628Glu His Glu Gly Leu Ser Lys Lys Ile Leu Ala Lys Met Asp Thr Ile
190 195 200TTG AGC GTA AAAATG CGA AGA GAT TTT GAT TCG CTC AAT GTG AGC GTG 676Leu Ser Val Lys Met Arg Arg Asp Phe Asp Ser Leu Asn Val Ser Val
205 210 215GCA GCA GGG ATC TTA ATG GAT AAA ATC AAC TAGGTGGTCA ATTGAATGGA ACA 729Ala Ala Gly Ile Leu Met Asp Lys Ile Asn
220 225GAATAAA 736
(2) Sequence 1362 data:
(i) sequence characteristics:
(A) length: 227 amino acids
(B) Type (2): amino acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: protein
(xi) Description of the sequence: sequence 1362: met Gln Ala Val Ile Tyr Gly Lys Gln Val Ile Met His Leu Leu Asn 151015 Ser His Gln Glu Lys Leu Gln Glu Ile Tyr Leu Ser Lys Glu Ile Asp
20 25 30Lys Lys Leu Phe Phe Ala Leu Lys Lys Ala Cys Pro Asn Ile Ile Lys
35 40 45Val Asp Asn Lys Lys Ala Gln Ser Leu Ala Lys Gly Gly Asn His Gln
50 55 60Gly Val Leu Ala Lys Val Glu Leu Pro Leu Ala Val Ser Leu Lys Glu65 70 75 80Val Lys Lys Ala Gln Lys Leu Leu Val Leu Cys Gly Ile Thr Asp Val
85 90 95Gly Asn Ile Gly Gly Ile Phe Arg Ser Ala Tyr Cys Leu Gly Met Gly
100 105 110Gly Val Ile Leu Asp Phe Ala Lys Glu Leu Ala Tyr Glu Gly Ile Val
115 120 125Arg Ser Ser Leu Gly Leu Met Tyr Asp Leu Pro Phe Ser Val Met Pro
130 135 140Asn Thr Leu Asp Leu Ile Asn Glu Leu Lys Thr Ser Gly Phe Leu Cys145 150 155 160Leu Gly Ala Ser Met Gln Gly Ser Ser Gln Ile Glu Asn Leu Ser Leu
165 170 175Lys Lys Cys Ala Leu Phe Leu Gly Ser Glu His Glu Gly Leu Ser Lys
180 185 190Lys Ile Leu Ala Lys Met Asp Thr Ile Leu Ser Val Lys Met Arg Arg
195 200 205Asp Phe Asp Ser Leu Asn Val Ser Val Ala Ala Gly Ile Leu Met Asp
210215220 Lys Ile Asn225 (2) sequence 1363 data: (i) sequence characteristics: length (A): 344bp (B) type: nucleic acid (C) strand type: single (D) topology: linear (ii) molecular type: genomic DNA (ix) characteristics: (A) name/keyword: position of coding sequence (B): 290 (D) other information: (xi) Description of the sequence: sequence 1363: AACCATGCCT TTTCATCGTC TCTATCAAA ATG TTA GGG TCT AAA ACA TAT TCC 53
Met Leu Gly Ser Lys Thr Tyr Ser
1 5GTT TTA AGA TCG TAT GAA AAA ACA TTC TCG CCT GAA GAG CTT TGC ATT 101Val Leu Arg Ser Tyr Glu Lys Thr Phe Ser Pro Glu Glu Leu Cys Ile
10 15 20TTA ATG GGC AAA ACA TAC GAA TAC CCC ATC ATG CTT AAA GAA TTA TTG 149Leu Met Gly Lys Thr Tyr Glu Tyr Pro Ile Met Leu Lys Glu Leu Leu25 30 35 40ATG CTT TTG GCA AAC GCT AGG GGA TTG CTT GAA GCC TTG AAA GTG ATT 197Met Leu Leu Ala Asn Ala Arg Gly Leu Leu Glu Ala Leu LysVal Ile
45 50 55TTC AAC ATG CTT GGC TTG TCA AAA TTA AAA GAC AAA AGC CCG TTT TCT 245Phe Asn Met Leu Gly Leu Ser Lys Leu Lys Asp Lys Ser Pro Phe Ser
60 65 70TTG AGA GTG TTG AGC AGT TTC AAG GAA TCC AAA CGC CCC ATT ACA TAGAA 295Leu Arg Val Leu Ser Ser Phe Lys Glu Ser Lys Arg Pro Ile Thr
758085 AGCCTTACGA TTTTTAAACA AACGCTCTAA AAAAAGCTTG TTCGTATGA 344 (2) sequence 1364 data: (i) sequence characteristics: length (A): 87 amino acids (B) type: amino acid (C) chain type: single (D) topology: linear (ii) molecular type: protein (xi) sequence description: sequence 1364: met Leu Gly Ser Lys Thr Tyr Ser Val Leu Arg Ser Tyr Glu Lys Thr 151015 Phe Ser Pro Glu Glu Leu Cys Ile Leu Met Gly Lys Thr Tyr Glu Tyr
20 25 30Pro Ile Met Leu Lys Glu Leu Leu Met Leu Leu Ala Asn Ala Arg Gly
35 40 45Leu Leu Glu Ala Leu Lys Val Ile Phe Asn Met Leu Gly Leu Ser Lys
50 55 60Leu Lys Asp Lys Ser Pro Phe Ser Leu Arg Val Leu Ser Ser Phe Lys65 70 75 80Glu Ser Lys Arg Pro Ile Thr
85
(2) Sequence 1365 data:
(i) sequence characteristics:
(A) length: 31bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(xi) Description of the sequence: sequence 1365: CTGAATTCGA ATGAAAAGAA TTTTAGTCTC T31
(2) Sequence 1366 data:
(i) sequence characteristics:
(A) length: 29bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(xi) Description of the sequence: sequence 1366: CCGCTCGAGT TAAAACTCAT AATTCAAAT 29
(2) Sequence 1367 data:
(i) sequence characteristics:
(A) length: 29bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(xi) Description of the sequence: sequence 1367: CGCGGATCCG AAGACATGTG CAACCGATG 29
(2) Sequence 1368 data:
(i) sequence characteristics:
(A) length: 30bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(xi) Description of the sequence: sequence 1368: CCGCTCGAGC TAAAAGTTTT GCAAAATCAC 30
(2) Sequence 1369 data:
(i) sequence characteristics:
(A) length: 32bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(xi) Description of the sequence: sequence 1369: CGCGGATCCG ATTTTACTTG AAAAATTTAA AC 32
(2) Sequence 1370:
(i) sequence characteristics:
(A) length: 31bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(xi) Description of the sequence: sequence 1370: CCGCTCGAGT TAGAAAGTGT AGTTCAAATA C31
(2) Sequence 1371 data:
(i) sequence characteristics:
(A) length: 24bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(xi) Description of the sequence: sequence 1371: GCGGATCCTT TTCTTCAATG TTTG 24
(2) Sequence 1372 data:
(i) sequence characteristics:
(A) length: 29bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: genomic DNA
(xi) Description of the sequence: sequence 1372: CCGCTCGAGT CAAAGTTTTA AACAAATTC 29
(2) Sequence 1373 data:
(i) sequence characteristics:
(A) length: 23bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: cDNA
(xi) Description of the sequence: sequence 1373: CCGAATTCGG TTATAAAGCC CCT 23
(2) Sequence 1374 data:
(i) sequence characteristics:
(A) length: 24bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: cDNA
(xi) Description of the sequence: sequence 1374: CCGCTCGAGT TAAGGCTGAT TTAA 24
(2) Sequence 1375 data:
(i) sequence characteristics:
(A) length: 32bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: cDNA
(xi) Description of the sequence: sequence 1375: CGCGGATCCG AGGAAATAGC ATGTTAATAA CC 32
(2) Sequence 1376 data:
(i) sequence characteristics:
(A) length: 33bp
(B) Type (2): nucleic acids
(C) Chain type: sheet
(D) Topological structure: line shape
(ii) Molecular type: cDNA
(xi) Description of the sequence: sequence 1376: CCGCTCGAGT CACTGCTTGC ATGACTTATT CCA 33
Other embodiments of the invention are encompassed by the following claims.

Claims (34)

1. An isolated polynucleotide encoding:
(i) a polypeptide comprising an amino acid sequence homologous to an amino acid sequence of a helicobacter polypeptide selected from the group consisting of:
GHPO 35(SEQ ID NO: 2), GHPO 55(SEQ ID NO: 4), GHPO78 (SEQ ID NO: 6), GHPO89 (SEQ ID NO: 8), GHPO129 (SEQ ID NO: 10), GHPO 541(SEQ ID NO: 12), GHPO 607(SEQ ID NO: 14), GHPO635(SEQ ID NO: 16), GHPO 701(SEQ ID NO: 18), GHPO 712(SEQ ID NO: 20), GHPO 761(SEQ ID NO: 22), GHPO 838(SEQ ID NO: 24), GHPO1034(SEQ ID NO: 26), GHPO 1085(SEQ ID NO: 28), GHPO 1213(SEQ ID NO: 30), GHPO 1255(SEQ ID NO: 32), GHPO 1308(SEQ ID NO: 34), GHPO 1381034 (SEQ ID NO: 36), GHPO 1706(SEQ ID NO: 38), GHPO 234(SEQ ID NO: 40), GHPO314(SEQ ID NO: 42), GHPO 510(SEQ ID NO: 44), GHPO603(SEQ ID NO: 46), GHPO 937(SEQ ID NO: 48), GHPO 1027(SEQ ID NO: 50), GHPO1099(SEQ ID NO: 52), GHPO 1151(SEQ ID NO: 54), GHPO1275(SEQ ID NO: 56), GHPO 1365(SEQ ID NO: 58), GHPO 1578(SEQ ID NO: 60), GHPO22(SEQ ID NO: 62), GHPO58 (SEQ ID NO: 64), GHPO 200(SEQ ID NO: 66), GHPO 558(SEQ ID NO: 68), GHPO 563(SEQ ID NO: 70), GHPO 695(SEQ ID NO: 72), GHPO 699(SEQ ID NO: 74), GHPO 702(SEQ ID NO: 76), GHPO709(SEQ ID NO: 78), GHPO 741(SEQ ID NO: 80), GHPO762(SEQ ID NO: 82), GHPO 827(SEQ ID NO: 84), GHPO 852(SEQ ID NO: 86), GHPO1013(SEQ ID NO: 88), GHPO 1020(SEQ ID NO: 90), GHPO1031(SEQ ID NO: 92), GHPO 1052(SEQ ID NO: 94), GHPO 1127(SEQ ID NO: 96), GHPO1149(SEQ ID NO: 98), GHPO 1176(SEQ ID NO: 100), GHPO1250(SEQ ID NO: 102), GHPO 1312(SEQ ID NO: 104), GHPO 1358(SEQ ID NO: 106), GHPO 1490(SEQ ID NO: 108), GHPO 1559(SEQ ID NO: 110), GHPO 1651(SEQ ID NO: 112), GHPO 1726(SEQ ID NO: 114), GHPO 1780(SEQ ID NO: 116), GHPO 895(SEQ ID NO: 118), GHPO 1447(SEQ ID NO: 120), GHPO28 (SEQ ID NO: 122), GHPO 86(SEQ ID NO: 124), GHPO155(SEQ ID NO: 126), GHPO 157(SEQ ID NO: 128), GHPO 237(SEQ ID NO: 130), GHPO 290(SEQ ID NO: 132), GHPO 293(SEQ ID NO: 134), GHPO335(SEQ ID NO: 136), GHPO 374(SEQ ID NO: 138), GHPO 442(SEQ ID NO: 140), GHPO 480(SEQ ID NO: 142), GHPO 523(SEQ ID NO: 144), GHPO610(SEQ ID NO: 146), GHPO 675(SEQ ID NO: 148), GHPO 690(SEQ ID NO: 150), GHPO 829(SEQ ID NO: 152), GHPO 850(SEQ ID NO: 154), GHPO876(SEQ ID NO: 156), GHPO 984(SEQ ID NO: 158), GHPO 989(SEQ ID NO: 160), GHPO 1111(SEQ ID NO: 162), GHPO 1145(SEQ ID NO: 164), GHPO 1256(SEQ ID NO: 166), GHPO 168(SEQ ID NO: 1264), GHPO 1316(SEQ ID NO: 170), GHPO 1368(SEQ ID NO: 172), GHPO 1442(SEQ ID NO: 174), GHPO 1506(SEQ ID NO: 176), GHPO 1543(SEQ ID NO: 178), GHPO 1574(SEQ ID NO: 180), GHPO 1627(SEQ ID NO: 182), GHPO 1657(SEQ ID NO: 184), GHPO 1664(SEQ ID NO: 186), GHPO 1694(SEQ ID NO: 188), GHPO 1704(SEQ ID NO: 190), GHPO 1763(SEQ ID NO: 192), GHPO 616(SEQ ID NO: 194), GHPO76 (SEQ ID NO: 196), GHPO109 (SEQ ID NO: 198), GHPO163 (SEQ ID NO: 200), GHPO (SEQ ID NO: 169: 202), GHPO 208(SEQ ID NO: 204), GHPO 219(SEQ ID NO: 206), GHPO 445(SEQ ID NO: 208), GHPO 479(SEQ ID NO: 210), GHPO 525(SEQ ID NO: 212), GHPO 535(SEQ ID NO: 214), GHPO 731(SEQ ID NO: 216), GHPO836(SEQ ID NO: 218), GHPO 879(SEQ ID NO: 220), GHPO 881(SEQ ID NO: 222), GHPO 886(SEQ ID NO: 224), GHPO 893(SEQ ID NO: 226), GHPO894(SEQ ID NO: 228), GHPO 976(SEQ ID NO: 230), GHPO 1011(SEQ ID NO: 232), GHPO 1024(SEQ ID NO: 234), GHPO 1084(SEQ ID NO: 236),GHPO 1329(SEQ ID NO: 238), GHPO 1330(SEQ ID NO: 240), GHPO 1346(SEQ ID NO: 242), GHPO 1360(SEQ ID NO: 244), GHPO 1388(SEQ ID NO: 246), GHPO248(SEQ ID NO: 141248), GHPO 9(SEQ ID NO: 250), GHPO 1446(SEQ ID NO: 144252), GHPO 1469(SEQ ID NO: 254), GHPO 1501(SEQ ID NO: 256), GHPO 1505(SEQ ID NO: 258), GHPO 1522(SEQ ID NO: 260), GHPO 1525(SEQ ID NO: 262), GHPO 1615(SEQ ID NO: 264), GHPO 1689(SEQ ID NO: 266), GHPO 1733(SEQ ID NO: 268), GHPO18 (SEQ ID NO: 270), GHPO 139(SEQ ID NO: 272), GHPO 142(SEQ ID NO: 274), GHPO 250(SEQ ID NO: 276), GHPO 257(SEQ ID NO: 278), GHPO325(SEQ ID NO: 280), GHPO 355(SEQ ID NO: 282), GHPO 357(SEQ ID NO: 284), GHPO 454(SEQ ID NO: 286), GHPO (475 ID NO: 288), GHPO515(SEQ ID NO: 290), GHPO 527(SEQ ID NO: 292), GHPO 551(SEQ ID NO: 294), GHPO 602(SEQ ID NO: 296), GHPO 626(SEQ ID NO: 298), GHPO646(SEQ ID NO: 300), GHPO 653(SEQ ID NO: 302), GHPO 655(SEQ ID NO: 304), GHPO 670(SEQ ID NO: 306), GHPO 739(SEQ ID NO: 308), GHPO798(SEQ ID NO: 310), GHPO 1102(SEQ ID NO: 312), GHPO 1114(SEQ ID NO: 314), GHPO 1152(SEQ ID NO: 316), GHPO 1272(SEQ ID NO: 318), GHPO 1345(SEQ ID NO: 320), GHPO 1377(SEQ ID NO: 322), GHPO 4(SEQ ID NO: 324), GHPO (1430 SEQ ID NO: 326), GHPO (SEQ ID NO: 328), GHPO 1600(SEQ ID NO: 330), GHPO 1714(SEQ ID NO: 332), GHPO 359(SEQ ID NO: 334), GHPO 678(SEQ ID NO: 336), GHPO 708(SEQ ID NO: 338), GHPO 759(SEQ ID NO: 340), GHPO 847(SEQ ID NO: 342), GHPO 1050(SEQ ID NO: 344), GHPO 1101(SEQ ID NO: 346), GHPO 1120(SEQ ID NO: 348), GHPO 1138(SEQ ID NO: 350), GHPO 1310(SEQ ID NO: 352), GHPO 1320(SEQ ID NO: 354), GHPO 1375(SEQ ID NO: 143356), GHPO 2(SEQ ID NO: 358), GHPO 21(SEQ ID NO: 360), GHPO282(SEQ ID NO: 362), GHPO 1089(SEQ ID NO: 364), GHPO 1141(SEQ ID NO: 366), GHPO 1280(SEQ ID NO: 368), GHPO (SEQ ID NO: 1608: 370), GHPO15 (SEQ ID NO: 372), GHPO16 (SEQ ID NO: 374), GHPO36 (SEQ ID NO: 378), GHPO38 (SEQ ID NO: 376), GHPO 52(SEQ ID NO: 380), GHPO57(SEQ ID NO: 382), GHPO64 (SEQ ID NO: 384), GHPO79 (SEQ ID NO: 386), GHPO 84(SEQ ID NO: 388), GHPO 86(SEQ ID NO: 390), GHPO99(SEQ ID NO: 392), GHPO 106(SEQ ID NO: 394), GHPO 118(SEQ ID NO: 396), GHPO 122(SEQ ID NO: 398), GHPO 128(SEQ ID NO: 400), GHPO138(SEQ ID NO: 402), GHPO 153(SEQ ID NO: 404), GHPO 160(SEQ ID NO: 406), GHPO 168(SEQ ID NO: 408), GHPO 179(SEQ ID NO: 410), GHPO189(SEQ ID NO: 412), GHPO 229(SEQ ID NO: 414), GHPO 243(SEQ ID NO: 416), GHPO 244(SEQ ID NO: 418), GHPO 251(SEQ ID NO: 420), GHPO267(SEQ ID NO: 422), GHPO 269(SEQ ID NO: 424), GHPO 279(SEQ ID NO: 426), GHPO 284(SEQ ID NO: 428), GHPO 296(SEQ ID NO: 430), GHPO300(SEQ ID NO: 432), GHPO 305(SEQ ID NO: 434), GHPO 319(SEQ ID NO: 436), GHPO 330(SEQ ID NO: 438), GHPO 340(SEQ ID NO: 440), GHPO342(SEQ ID NO: 442), GHPO 344(SEQ ID NO: 444), GHPO 358(SEQ ID NO: 446), GHPO 373(SEQ ID NO: 448), GHPO 382(SEQ ID NO: 450), GHPO384(SEQ ID NO: 452), GHPO 398(SEQ ID NO: 454), GHPO (SEQ ID NO: 409), GHPO 422(SEQ ID NO: 458), GHPO 430(SEQ ID NO: 460), GHPO446(SEQ ID NO: 462), GHPO 447(SEQ ID NO: 464), GHPO 450(SEQ ID NO: 466), GHPO 451(SEQ ID NO: 468), GHPO 452(SEQ ID NO: 470), GHPO456(SEQ ID NO: 472), GHPO 461(SEQ ID NO: 474), GHPO 476(SEQ ID NO: 476), GHPO 478(SEQ ID NO: 478), GHPO 491(SEQ ID NO: 480), GHPO511(SEQ ID NO: 482), GHPO 519(SEQ ID NO: 484), GHPO 526(SEQ ID NO: 486), GHPO 534(SEQ ID NO: 488), GHPO 536(SEQ ID NO: 490), GHPO542(SEQ ID NO: 492), GHPO 544(SEQ ID NO: 494), GHPO 496(SEQ ID NO: 496), GHPO 578(SEQ ID NO: 498), GHPO 580(SEQ ID NO: 500), GHPO585(SEQ ID NO: 502), GHPO 599(SEQ ID NO: 504), GHPO 639(SEQ ID NO: 506), GHPO 508 (SEQ ID NO: 508), GHPO 647(SEQ ID NO: 510), GHPO654(SEQ ID NO: 512), GHPO 669(SEQ ID NO: 514), GHPO 710(SEQ ID NO: 516), GHPO 713(SEQ ID NO: 518), GHPO 716(SEQ ID NO: 520), GHPO718(SEQ ID NO: 522), GHPO 726(SEQ ID NO: 524), GHPO 734(SEQ ID NO: 526), GHPO 740(SEQ ID NO: 528), GHPO 770(SEQ ID NO: 530), GHPO782(SEQ ID NO: 532), GHPO 786(SEQ ID NO: 534), GHPO 792(SEQ ID NO: 536), GHPO 797(SEQ ID NO: 538), GHPO 816(SEQ ID NO: 540), GHPO828(SEQ ID NO: 542), GHPO 839(SEQ ID NO: 544), GHPO 840(SEQ ID NO: 546), GHPO 842(SEQ ID NO: 548), GHPO 885(SEQ ID NO: 88550), GHPO889(SEQ IDNO: 552), GHPO 903(SEQ ID NO: 554), GHPO 912(SEQ ID NO: 556), GHPO 946(SEQ ID NO: 558), GHPO 958(SEQ ID NO: 560), GHPO968(SEQ ID NO: 562), GHPO 987(SEQ ID NO: 564), GHPO 992(SEQ ID NO: 566), GHPO 996(SEQ ID NO: 568), GHPO 997(SEQ ID NO: 570), GHPO1002(SEQ ID NO: 572), GHPO 1026(SEQ ID NO: 574), GHPO 1028(SEQ ID NO: 576), GHPO1034(SEQ ID NO: 578), GHPO 1038(SEQ ID NO: 580), GHPO 1059(SEQ ID NO: 582), GHPO 1065(SEQ ID NO: S84), GHPO 1072(SEQ ID NO: 586), GHPO 1073(SEQ ID NO: 588), GHPO 1088(SEQ ID NO: 108590), GHPO 1091(SEQ ID NO: 109592), GHPO 1105(SEQ ID NO: 594), GHPO 1115(SEQ ID NO: 596), GHPO 1159(SEQ ID NO: 598), GHPO 1177(SEQ ID NO: 600), GHPO 1187(SEQ ID NO: 602), GHPO 1192(SEQ ID NO: 604), GHPO 1195(SEQ ID NO: 606), GHPO 1224(SEQ ID NO: 608), GHPO 1225(SEQ ID NO: 610), GHPO 1228(SEQ ID NO: 612), GHPO 1229(SEQ ID NO: 614), GHPO 1231(SEQ ID NO: 616), GHPO 1236(SEQ ID NO: 618), GHPO 1242(SEQ ID NO: 620), GHPO 1248(SEQ ID NO: 622), GHPO 1270(SEQ ID NO: 624), GHPO 1271(SEQ ID NO: 626), GHPO 1298(SEQ ID NO: 628), GHPO (SEQ ID NO: 1304), GHPO (SEQ ID NO: 630), GHPO 1304(SEQ ID NO: 632, GHPO 1315(SEQ ID NO: 1315), GHPO 1319(SEQ ID NO: 636), GHPO 1323(SEQ ID NO: 638), GHPO 1331(SEQ ID NO: 640), GHPO 1332(SEQ ID NO: 642), GHPO 1347(SEQ ID NO: 644), GHPO 1373(SEQ ID NO: 646), GHPO 1376(SEQ ID NO: 648), GHPO 1380(SEQ ID NO: 650), GHPO 1394 PO 1394(SEQ ID NO: 652), GHPO 1407(SEQ ID NO: 654), GHPO 5(SEQ ID NO: 141141141656), GHPO 1425(SEQ ID NO: 658), GHPO 1427(SEQ ID NO: 660), GHPO 1444(SEQ ID NO: 662), GHPO 1449(SEQ ID NO: 664), GHPO 1465(SEQ ID NO: 666), GHPO 1475(SEQ ID NO: 668), GHPO 1479(SEQ ID NO: 670), GHPO 1483(SEQ ID NO: 1483), GHPO 674 (SEQ ID NO: 674), GHPO 674 (SEQ ID NO: 672), GHPO 1496(SEQ ID NO: 149676), GHPO 1524(SEQ ID NO: 678), GHPO 1536(SEQ ID NO: 680), GHPO 1539(SEQ ID NO: 682), GHPO 1540(SEQ ID NO: 684), GHPO 1542(SEQ ID NO: 686), GHPO 1555(SEQ ID NO: 688), GHPO 1560(SEQ ID NO: 690), GHPO 1564(SEQ ID NO: 692), GHPO 1570(SEQ ID NO: 694), GHPO 1588(SEQ ID NO: 696), GHPO 1604(SEQ ID NO: 698), GHPO 1605(SEQ ID NO: 700), GHPO 1619(SEQ ID NO: 702), GHPO 1629(SEQ ID NO: 704: 718), GHPO 1642(SEQ ID NO: 706), GHPO 1654(SEQ ID NO: 708), GHPO 1661(SEQ ID NO: 710), GHPO 1673(SEQ ID NO: 712), GHPO 1687(SEQ ID NO: 16892), GHPO 15392 (SEQ ID NO: 16993), GHPO 16993), GHPO 1699(SEQ ID NO: 720), GHPO 1738(SEQ ID NO: 722), GHPO 1745(SEQ ID NO: 724), GHPO 1746(SEQ ID NO: 726), GHPO 1754(SEQ ID NO: 728), GHPO 1792(SEQ ID NO: 730), GHPO 1795(SEQ ID NO: 732), GHPO 1796(SEQ ID NO: 734), GHPO 7(SEQ ID NO: 736), GHPO 8(SEQ ID NO: 738), GHPO 9(SEQ ID NO: 740), GHPO10 (SEQ ID NO: 742), GHPO12 (SEQ ID NO: 744), GHPO25(SEQ ID NO: 746), GHPO27 (SEQ ID NO: 748), GHPO 29(SEQ ID NO: 750), GHPO30 (SEQ ID NO: 752), GHPO 37(SEQ ID NO: 754), GHPO49(SEQ ID NO: 756), GHPO51 (SEQ ID NO: 758), GHPO54 (SEQ ID NO: 760), GHPO65 (SEQ ID NO: 762), GHPO 66(SEQ ID NO: 764), GHPO68(SEQ ID NO: 766), GHPO70 (SEQ ID NO: 768), GHPO 77(SEQ ID NO: 770), GHPO83 (SEQ ID NO: 772), GHPO 85(SEQ ID NO: 774), GHPO87(SEQ ID NO: 776), GHPO 91(SEQ ID NO: 778), GHPO 92(SEQ ID NO: 780), GHPO96 (SEQ ID NO: 782), GHPO 97(SEQ ID NO: 784), GHPO111(SEQ ID NO: 786), GHPO 115(SEQ ID NO: 788), GHPO117 (SEQ ID NO: 790), GHPO 123(SEQ ID NO: 792), GHPO 124(SEQ ID NO: 794), GHPO126(SEQ ID NO: 796), GHPO127 (SEQ ID NO: 798), GHPO 128(SEQ ID NO: 800), GHPO 131(SEQ ID NO: 802), GHPO 133(SEQ ID NO: 804), GHPO140(SEQ ID NO: 806), GHPO141 (SEQ ID NO: 808), GHPO 145(SEQ ID NO: 810), GHPO 147(SEQ ID NO: 812), GHPO 166(SEQ ID NO: 814), GHPO181(SEQ ID NO: 816), GHPO 187(SEQ ID NO: 818), GHPO 188(SEQ ID NO: 820), GHPO 192(SEQ ID NO: 822), GHPO 202(SEQ ID NO: 824), GHPO204(SEQ ID NO: 826), GHPO 205(SEQ ID NO: 828), GHPO 212(SEQ ID NO: 830), GHPO 218(SEQ ID NO: 832), GHPO 226(SEQ ID NO: 834), GHPO231(SEQ ID NO: 836), GHPO 236(SEQ ID NO: 838), GHPO 239(SEQ ID NO: 840), GHPO 245(SEQ ID NO: 842), GHPO 246(SEQ ID NO: 844), GHPO248(SEQ ID NO: 846), GHPO 253(SEQ ID NO: 848), GHPO 265(SEQ ID NO: 850), GHPO 266(SEQ ID NO: 852), GHPO 271(SEQ ID NO: 854), GHPO272(SEQ ID NO: 856), GHPO 286(SEQ ID NO: 858), GHPO 291(SEQ ID NO: 860), GHPO 292(SEQ ID NO: 862), GHPO 297(SEQ ID NO: 864), GHPO304(SEQ ID NO: 866), GHPO 307(SEQ ID NO: 868), GHPO 324(SEQ ID NO: 870), GHPO 326(SEQ ID NO: 872), GHPO 331(SEQ ID NO: 874), GHPO343(SEQ ID NO: 876), GHPO 345(SEQ ID NO: 878), GHPO 346(SEQ ID NO: 880), GHPO 352(SEQ ID NO: 882), GHPO 355(SEQ ID NO: 884), GHPO363(SEQ ID NO: 886), GHPO 886(SEQ ID NO: 88888), GHPO 376(SEQ ID NO: 890), GHPO 378(SEQ ID NO: 892), GHPO 388(SEQ ID NO: 894), GHPO396(SEQ ID NO: 896), GHPO 403(SEQ ID NO: 898), GHPO 410(SEQ ID NO: 900), GHPO 415(SEQ ID NO: 902), GHPO 421(SEQ ID NO: 904), GHPO439(SEQ ID NO: 906), GHPO 441(SEQ ID NO: 908), GHPO 443(SEQ ID NO: 910), GHPO 453(SEQ ID NO: 912), GHPO 455(SEQ ID NO: 914), GHPO464(SEQ ID NO: 916), GHPO 467(SEQ ID NO: 918), GHPO 468(SEQ ID NO: 920), GHPO 470(SEQ ID NO: 922), GHPO (SEQ ID NO: 924), GHPO487(SEQ ID NO: 926), GHPO 928 (SEQ ID NO: 488), GHPO 9(SEQ ID NO: 48930), GHPO 498(SEQ ID NO: 932), GHPO 501(SEQ ID NO: 934), GHPO504(SEQ ID NO: 936), GHPO 512(SEQ ID NO: 938), GHPO 517(SEQ ID NO: 940), GHPO 520(SEQ ID NO: 942), GHPO 528(SEQ ID NO: 944), GHPO530(SEQ ID NO: 946), GHPO 532(SEQ ID NO: 948), GHPO 548(SEQ ID NO: 950), GHPO 561(SEQ ID NO: 952), GHPO 564(SEQ ID NO: 954), GHPO572(SEQ ID NO: 956), GHPO 573(SEQ ID NO: 958), GHPO 574(SEQ ID NO: 960), GHPO 577(SEQ ID NO: 962), GHPO 579(SEQ ID NO: 964), GHPO583(SEQ ID NO: 966), GHPO (SEQ ID NO: 968), GHPO 593(SEQ ID NO: 970), GHPO 597(SEQ ID NO: 588 NO: 597), GHPO 598), GHPO 594 (SEQ ID NO: 59974), GHPO604(SEQ ID NO: 976), GHPO 606(SEQ ID NO: 978), GHPO 611(SEQ ID NO: 980), GHPO 612(SEQ ID NO: 982), GHPO 615(SEQ ID NO: 984), GHPO632(SEQ ID NO: 986), GHPO 633(SEQ ID NO: 988), GHPO 637(SEQ ID NO: 990), GHPO 651(SEQ ID NO: 992), GHPO 663(SEQ ID NO: 994), GHPO (SEQ ID NO: 996), GHPO 693(SEQ ID NO: 998), GHPO 698(SEQ ID NO: 1000), GHPO 703(SEQ ID NO: 1002), GHPO 704(SEQ ID NO: 1004), GHPO 705(SEQ ID NO: 1006), GHPO 707 PO (SEQ ID NO: 1008), GHPO 721 PO (SEQ ID NO: 1010), GHPO 727(SEQ ID NO: 1012), GHPO 728(SEQ ID NO: 728), GHPO 1014 NO: 1014), GHPO 758(SEQ ID NO: 1018), GHPO 763(SEQ ID NO: 1020), GHPO 771(SEQ ID NO: 1022), GHPO 774(SEQ ID NO: 1024), GHPO 776(SEQ ID NO: 1026), GHPO 783(SEQ ID NO: 1028), GHPO 800(SEQ ID NO: 1030), GHPO 806(SEQ ID NO: 1032), GHPO 807(SEQ ID NO: 1034), GHPO (SEQ ID NO: 1036), GHPO 809(SEQ ID NO: 1038), GHPO 811(SEQ ID NO: 1040), GHPO 815(SEQ ID NO: 1042), GHPO 819(SEQ ID NO: 1044), GHPO 841(SEQ ID NO: 1046), GHPO 843(SEQ ID NO: 1048), GHPO 846(SEQ ID NO: 8921050), GHPO 875(SEQ ID NO: 1052), GHPO (SEQ ID NO: 1054), GHPO (SEQ ID NO: 1056), GHPO 768), GHPO 906(SEQ ID NO: 1060), GHPO 908(SEQ ID NO: 1062), GHPO 921(SEQ ID NO: 1064), GHPO 923(SEQ ID NO: 1066), GHPO 926(SEQ ID NO: 1068), GHPO 933(SEQ ID NO: 1070), GHPO 939(SEQ ID NO: 1072), GHPO 940(SEQ ID NO: 1074), GHPO 943(SEQ ID NO: 1076), GHPO 951(SEQ ID NO: 1078), GHPO 961(SEQ ID NO: 1080), GHPO 965(SEQ ID NO: 1082), GHPO 990(SEQ ID NO: 1084), GHPO 991(SEQ ID NO: 1086), GHPO 998(SEQ ID NO: 1088), GHPO 1001(SEQ ID NO: 1098), GHPO 1090(SEQ ID NO: 1092), GHPO1033(SEQ ID NO: 1094), GHPO 9(SEQ ID NO: 1046), GHPO 1001(SEQ ID NO: 1098), GHPO 1100 (SEQ ID NO: 1098), GHPO 1091100), GHPO 1044(SEQ ID NO: 1102), GHPO 1051(SEQ ID NO: 1104), GHPO 1058(SEQ ID NO: 1106), GHPO 1060(SEQ ID NO: 1108), GHPO 1075(SEQ ID NO: 1110), GHPO1077(SEQ ID NO: 1112), GHPO 1082(SEQ ID NO: 1114), GHPO 1083(SEQ ID NO: 1116), GHPO 1086(SEQ ID NO: 1118), GHPO 1087(SEQ ID NO: 1120), GHPO 1090(SEQ ID NO: 1122), GHPO 1097(SEQ ID NO: 1124), GHPO 1098(SEQ ID NO: 1126), GHPO 1103(SEQ ID NO: 1128), GHPO1113(SEQ ID NO: 1130), GHPO (SEQ ID NO: 1132), GHPO 3(SEQ ID NO: 1134), GHPO 1116(SEQ ID NO: 11256), GHPO 1129(SEQ ID NO: 1138), GHPO 1130(SEQ ID NO: 1130), GHPO 1140), GHPO 4(SEQ ID NO: 1142), GHPO 1161(SEQ ID NO: 1144), GHPO 1166(SEQ ID NO: 1146), GHPO1170(SEQ ID NO: 1148), GHPO 1175(SEQ ID NO: 1150), GHPO 1181(SEQ ID NO: 1152), GHPO 1186(SEQ ID NO: 1154), GHPO 1188(SEQ ID NO: 1156), GHPO 1191(SEQ ID NO: 1158), GHPO 1193(SEQ ID NO: 1160), GHPO 1196(SEQ ID NO: 1162), GHPO 1204(SEQ ID NO: 1164), GHPO1210(SEQ ID NO: 1166), GHPO 1211(SEQ ID NO: 1168), GHPO 1216(SEQ ID NO: 1170), GHPO 1218(SEQ ID NO: 1172), GHPO 1220(SEQ ID NO: 1174), GHPO 1223(SEQ ID NO: 1176), GHPO 1226(SEQ ID NO: 1178), GHPO 1240(SEQ ID NO: 1240), GHPO 1186(SEQ ID NO: 1181251), GHPO 1254), GHPO 1252(SEQ ID NO: 1186), GHPO 1261(SEQ ID NO: 1188), GHPO 1265(SEQ ID NO: 1190), GHPO 1267(SEQ ID NO: 1192), GHPO 1278(SEQ ID NO: 1194), GHPO 1282(SEQ ID NO: 1196), GHPO 1283(SEQ ID NO: 1198), GHPO 1287(SEQ ID NO: 1200), GHPO1292(SEQ ID NO: 1202), GHPO 1293(SEQ ID NO: 1204), GHPO (SEQ ID NO: 1206), GHPO 1309(SEQ ID NO: 1208), GHPO 1317(SEQ ID NO: 1210), GHPO 1318(SEQ ID NO: 1212), GHPO 1321(SEQ ID NO: 1214), GHPO 1325(SEQ ID NO: 1216), GHPO 134PO 1(SEQ ID NO: 1351351222), GHPO 1(SEQ ID NO: 1220), GHPO 1354(SEQ ID NO: 1363), GHPO 1224(SEQ ID NO: 1376), GHPO 1381(SEQ ID NO: 1228), GHPO 1401(SEQ ID NO: 1230), GHPO 1402(SEQ ID NO: 1232), GHPO 1403(SEQ ID NO: 1234), GHPO 1408(SEQ ID NO: 1236), GHPO1416(SEQ ID NO: 1238), GHPO 1420(SEQ ID NO: 1240), GHPO 8(SEQ ID NO: 1242), GHPO 1437(SEQ ID NO: 1244), GHPO 1439(SEQ ID NO: 1246), GHPO 1460(SEQ ID NO: 1248), GHPO 1463(SEQ ID NO: 1250), GHPO 1472(SEQ ID NO: 1252), GHPO 1474(SEQ ID NO: 1254), GHPO1484(SEQ ID NO: 1256), GHPO 1489(SEQ ID NO: 1258), GHPO 1494(SEQ ID NO: 1260), GHPO 5(SEQ ID NO: 1492), GHPO 1498(SEQ ID NO: 1491269), GHPO 1499(SEQ ID NO: 1498), GHPO 1491268), GHPO 1503(SEQ ID NO: 1270), GHPO 1504(SEQ ID NO: 1272), GHPO1510(SEQ ID NO: 1274), GHPO 1518(SEQ ID NO: 1276), GHPO 1533(SEQ ID NO: 1278), GHPO 1541(SEQ ID NO: 1280), GHPO 1544(SEQ ID NO: 1282), GHPO 1548(SEQ ID NO: 1284), GHPO 1565(SEQ ID NO: 1286), GHPO 1575(SEQ ID NO: 1288), GHPO 1582(SEQ ID NO: 1290), GHPO1595(SEQ ID NO: 1292), GHPO 1597(SEQ ID NO: 1294), GHPO 1599(SEQ ID NO: 1296), GHPO 1601(SEQ ID NO: 1298), GHPO 1609(SEQ ID NO: 1300), GHPO 1613(SEQ ID NO: 1631302), GHPO 1614(SEQ ID NO: 1304), GHPO 6(SEQ ID NO: 1310), GHPO 1628(SEQ ID NO: 1629), GHPO 1629(SEQ ID NO: 1308), GHPO 1640(SEQ ID NO: 1312), GHPO 1641(SEQ ID NO: 1314), GHPO 1646(SEQID NO: 1316), GHPO 1662(SEQ ID NO: 1318), GHPO 1667(SEQ ID NO: 1320), GHPO 1668(SEQ ID NO: 1322), GHPO 1670(SEQ ID NO: 1324), GHPO 1671(SEQ ID NO: 1326), GHPO1672(SEQ ID NO: 1328), GHPO 8(SEQ ID NO: 1671330), GHPO 1684(SEQ ID NO: 1332), GHPO 1695(SEQ ID NO: 1334), GHPO 1697(SEQ ID NO: 1336), GHPO 1701(SEQ ID NO: 1338), GHPO 1719(SEQ ID NO: 1340), GHPO 1723(SEQ ID NO: 1342), GHPO 2(SEQ ID NO: 1341744), GHPO 1731349 (SEQ ID NO: 1346), GHPO 1341(SEQ ID NO: 1731348), GHPO 1347(SEQ ID NO: 1351359), GHPO 1742 (SEQ ID NO: 1744), GHPO 1750(SEQ ID NO: 1354), GHPO 1751(SEQ ID NO: 1356), GHPO 1755(SEQ ID NO: 1358), GHPO 1771(SEQ ID NO: 1360), GHPO 1786(SEQ ID NO: 1362), and GHPO1789(SEQ ID NO: 1364); or
(ii) Derivatives of said helicobacter polypeptides.
2. The isolated polynucleotide of claim 1, which encodes a mature form of said helicobacter polypeptide.
3. The isolated polynucleotide of claim 1 or 2, wherein the polynucleotide is a DNA molecule.
4. The isolated polynucleotide of claim 1 which is a DNA molecule that can be amplified from the helicobacter genome by the polymerase chain reaction.
5. The isolated DNA molecule of claim 4 which is amplified from the helicobacter pylori genome by the polymerase chain reaction.
6. The isolated polynucleotide of claim 1 which is a DNA molecule encoding a mature form or derivative of the polypeptide encoded by the DNA molecule of claim 4.
7. The isolated polynucleotide of claim 1 which is a DNA molecule encoding a mature form or derivative of the polypeptide encoded by the DNA molecule of claim 5.
8. A compound in substantially purified form which is a mature form or derivative of a polypeptide comprising an amino acid sequence homologous to a helicobacter polypeptide selected from the group consisting of:
GHPO 35(SEQ ID NO: 2), GHPO 55(SEQ ID NO: 4), GHPO78 (SEQ ID NO: 6), GHPO89 (SEQ ID NO: 8), GHPO129 (SEQ ID NO: 10), GHPO 541(SEQ ID NO: 12), GHPO 607(SEQ ID NO: 14), GHPO635(SEQ ID NO: 16), GHPO 701(SEQ ID NO: 18), GHPO 712(SEQ ID NO: 20), GHPO 761(SEQ ID NO: 22), GHPO 838(SEQ ID NO: 24), GHPO1034(SEQ ID NO: 26), GHPO 1085(SEQ ID NO: 28), GHPO 1213(SEQ ID NO: 30), GHPO 1255(SEQ ID NO: 32), GHPO 1308(SEQ ID NO: 34), GHPO 1381034 (SEQ ID NO: 36), GHPO 1706(SEQ ID NO: 38), GHPO 234(SEQ ID NO: 40), GHPO314(SEQ ID NO: 42), GHPO 510(SEQ ID NO: 44), GHPO603(SEQ ID NO: 46), GHPO 937(SEQ ID NO: 48), GHPO 1027(SEQ ID NO: 50), GHPO1099(SEQ ID NO: 52), GHPO 1151(SEQ ID NO: 54), GHPO1275(SEQ ID NO: 56), GHPO 1365(SEQ ID NO: 58), GHPO 1578(SEQ ID NO: 60), GHPO22(SEQ ID NO: 62), GHPO58 (SEQ ID NO: 64), GHPO 200(SEQ ID NO: 66), GHPO 558(SEQ ID NO: 68), GHPO 563(SEQ ID NO: 70), GHPO 695(SEQ ID NO: 72), GHPO 699(SEQ ID NO: 74), GHPO 702(SEQ ID NO: 76), GHPO709(SEQ ID NO: 78), GHPO (SEQ ID NO: 741), GHPO762(SEQ ID NO: 80), GHPO762(SEQ ID NO: 82), GHPO 84), GHPO 852(SEQ ID NO: 86), GHPO1013(SEQ ID NO: 88), GHPO 1020(SEQ ID NO: 90), GHPO1031(SEQ ID NO: 92), GHPO 1052(SEQ ID NO: 94), GHPO 1127(SEQ ID NO: 96), GHPO1149(SEQ ID NO: 98), GHPO 1176(SEQ ID NO: 100), GHPO1250(SEQ ID NO: 102), GHPO 1312(SEQ ID NO: 104), GHPO 1358(SEQ ID NO: 106), GHPO 1490(SEQ ID NO: 108), GHPO 1559(SEQ ID NO: 110),GHPO 1651(SEQ ID NO: 112), GHPO 1726(SEQ ID NO: 114), GHPO 1780(SEQ ID NO: 116), GHPO 895(SEQ ID NO: 118), GHPO 1447(SEQ ID NO: 120), GHPO28 (SEQ ID NO: 122), GHPO 86(SEQ ID NO: 124), GHPO155(SEQ ID NO: 126), GHPO 157(SEQ ID NO: 128), GHPO 237(SEQ ID NO: 130), GHPO 290(SEQ ID NO: 132), GHPO 293(SEQ ID NO: 134), GHPO335(SEQ ID NO: 136), GHPO 374(SEQ ID NO: 138), GHPO 442(SEQ ID NO: 140), GHPO 480(SEQ ID NO: 142), GHPO 523(SEQ ID NO: 144), GHPO610(SEQ ID NO: 146), GHPO 675(SEQ ID NO: 148), GHPO 690(SEQ ID NO: 150), GHPO 829(SEQ ID NO: 152), GHPO 850(SEQ ID NO: 154), GHPO876(SEQ ID NO: 156), GHPO 984(SEQ ID NO: 158), GHPO 989(SEQ ID NO: 160), GHPO 1111(SEQ ID NO: 162), GHPO 1145(SEQ ID NO: 164), GHPO 1256(SEQ ID NO: 166), GHPO 168(SEQ ID NO: 1264), GHPO 1316(SEQ ID NO: 170), GHPO 1368(SEQ ID NO: 172), GHPO 1442(SEQ ID NO: 174), GHPO 1506(SEQ ID NO: 176), GHPO 1543(SEQ ID NO: 178), GHPO 1574(SEQ ID NO: 180), GHPO 1627(SEQ ID NO: 182), GHPO 1657(SEQ ID NO: 184), GHPO 1664(SEQ ID NO: 186), GHPO 1694(SEQ ID NO: 188), GHPO 1704(SEQ ID NO: 190), GHPO 1763(SEQ ID NO: 192), GHPO 616(SEQ ID NO: 194), GHPO76 (SEQ ID NO: 196), GHPO109 (SEQ ID NO: 198), GHPO163 (SEQ ID NO: 200), GHPO (SEQ ID NO: 169: 202), GHPO 208(SEQ ID NO: 204), GHPO 219(SEQ ID NO: 206), GHPO 445(SEQ ID NO: 208), GHPO 479(SEQ ID NO: 210), GHPO 525(SEQ ID NO: 212), GHPO 535(SEQ ID NO: 214), GHPO 731(SEQ ID NO: 216), GHPO836(SEQ ID NO: 218), GHPO 879(SEQ ID NO: 220), GHPO 881(SEQ ID NO: 222), GHPO 886(SEQ ID NO: 224), GHPO 893(SEQ ID NO: 226), GHPO894(SEQ ID NO: 228), GHPO 976(SEQ ID NO: 230), GHPO 1011(SEQ ID NO: 232), GHPO 1024(SEQ ID NO: 234), GHPO 1084(SEQ ID NO: 236), GHPO 1329(SEQ ID NO: 238), GHPO 1330(SEQ ID NO: 240), GHPO 1346(SEQ ID NO: 242), GHPO 1360(SEQ ID NO: 244), GHPO 1388(SEQ ID NO: 246), GHPO248(SEQ ID NO: 141248), GHPO 9(SEQ ID NO: 250), GHPO 1446(SEQ ID NO: 144252), GHPO 1469(SEQ ID NO: 254), GHPO 1501(SEQ ID NO: 256), GHPO 1505(SEQ ID NO: 258), GHPO 1522(SEQ ID NO: 260), GHPO 1525(SEQ ID NO: 262), GHPO 1615(SEQ ID NO: 264), GHPO 1689(SEQ ID NO: 266), GHPO 1733(SEQ ID NO: 268), GHPO18 (SEQ ID NO: 270), GHPO 139(SEQ ID NO: 272), GHPO 142(SEQ ID NO: 274), GHPO 250(SEQ ID NO: 276), GHPO 257(SEQ ID NO: 278), GHPO325(SEQ ID NO: 280), GHPO 355(SEQ ID NO: 282), GHPO 357(SEQ ID NO: 284), GHPO 454(SEQ ID NO: 286), GHPO (475 ID NO: 288), GHPO515(SEQ ID NO: 290), GHPO 527(SEQ ID NO: 292), GHPO 551(SEQ ID NO: 294), GHPO 602(SEQ ID NO: 296), GHPO 626(SEQ ID NO: 298), GHPO646(SEQ ID NO: 300), GHPO 653(SEQ ID NO: 302), GHPO 655(SEQ ID NO: 304), GHPO 670(SEQ ID NO: 306), GHPO 739(SEQ ID NO: 308), GHPO798(SEQ ID NO: 310), GHPO 1102(SEQ ID NO: 312), GHPO 1114(SEQ ID NO: 314), GHPO 1152(SEQ ID NO: 316), GHPO 1272(SEQ ID NO: 318), GHPO 1345(SEQ ID NO: 320), GHPO 1377(SEQ ID NO: 322), GHPO 4(SEQ ID NO: 324), GHPO (1430 SEQ ID NO: 326), GHPO (SEQ ID NO: 328), GHPO 1600(SEQ ID NO: 330), GHPO 1714(SEQ ID NO: 332), GHPO 359(SEQ ID NO: 334), GHPO 678(SEQ ID NO: 336), GHPO 708(SEQ ID NO: 338), GHPO 759(SEQ ID NO: 340), GHPO 847(SEQ ID NO: 342), GHPO 1050(SEQ ID NO: 344), GHPO 1101(SEQ ID NO: 346), GHPO 1120(SEQ ID NO: 348), GHPO 1138(SEQ ID NO: 350), GHPO 1310(SEQ ID NO: 352), GHPO 1320(SEQ ID NO: 354), GHPO 1375(SEQ ID NO: 143356), GHPO 2(SEQ ID NO: 358), GHPO 21(SEQ ID NO: 360), GHPO282(SEQ ID NO: 362), GHPO 1089(SEQ ID NO: 364), GHPO 1141(SEQ ID NO: 366), GHPO 1280(SEQ ID NO: 368), GHPO (SEQ ID NO: 1608: 370), GHPO15 (SEQ ID NO: 372), GHPO16 (SEQ ID NO: 374), GHPO36 (SEQ ID NO: 378), GHPO38 (SEQ ID NO: 376), GHPO 52(SEQ ID NO: 380), GHPO57(SEQ ID NO: 382), GHPO64 (SEQ ID NO: 384), GHPO79 (SEQ ID NO: 386), GHPO 84(SEQ ID NO: 388), GHPO 86(SEQ ID NO: 390), GHPO99(SEQ ID NO: 392), GHPO 106(SEQ ID NO: 394), GHPO 118(SEQ ID NO: 396), GHPO 122(SEQ ID NO: 398), GHPO 128(SEQ ID NO: 400), GHPO138(SEQ ID NO: 402), GHPO 153(SEQ ID NO: 404), GHPO 160(SEQ ID NO: 406), GHPO 168(SEQ ID NO: 408), GHPO 179(SEQ ID NO: 410), GHPO189(SEQ ID NO: 412), GHPO 229(SEQ ID NO: 414), GHPO 243(SEQ ID NO: 416), GHPO 244(SEQ ID NO: 418), GHPO 251(SEQ ID NO: 420), GHPO267(SEQ ID NO: 422), GHPO 269(SEQ ID NO: 424), GHPO 279(SEQ ID NO: 426), GHPO 284(SEQ ID NO: 428), GHPO 296(SEQ ID NO: 430), GHPO300(SEQ ID NO: 432), GHPO 305(SEQ ID NO: 434), GHPO 319(SEQ ID NO: 436), GHPO 330(SEQ ID NO: 438), GHPO 340(SEQ ID NO: 440), GHPO342(SEQ ID NO: 442), GHPO 344(SEQ ID NO: 444), GHPO 358(SEQ ID NO: 446), GHPO 373(SEQ ID NO: 448), GHPO 382(SEQ ID NO: 450), GHPO384(SEQ ID NO: 452), GHPO 398(SEQ ID NO: 454), GHPO (SEQ ID NO: 409), GHPO 422(SEQ ID NO: 458), GHPO 430(SEQ ID NO: 460), GHPO446(SEQ ID NO: 462), GHPO 447(SEQ ID NO: 464), GHPO 450(SEQ ID NO: 466), GHPO 451(SEQ ID NO: 468), GHPO 452(SEQ ID NO: 470), GHPO456(SEQ ID NO: 472), GHPO 461(SEQ ID NO: 474), GHPO 476(SEQ ID NO: 476), GHPO 478(SEQ ID NO: 478), GHPO 491(SEQ ID NO: 480), GHPO511(SEQ ID NO: 482), GHPO 519(SEQ ID NO: 484), GHPO 526(SEQ ID NO: 486), GHPO 534(SEQ ID NO: 488), GHPO 536(SEQ ID NO: 490), GHPO542(SEQ ID NO: 492), GHPO 544(SEQ ID NO: 494), GHPO 496(SEQ ID NO: 496), GHPO 578(SEQ ID NO: 498), GHPO 580(SEQ ID NO: 500), GHPO585(SEQ ID NO: 502), GHPO 599(SEQ ID NO: 504), GHPO 639(SEQ ID NO: 506), GHPO 508 (SEQ ID NO: 508), GHPO 647(SEQ ID NO: 510), GHPO654(SEQ ID NO: 512), GHPO 669(SEQ ID NO: 514), GHPO 710(SEQ ID NO: 516), GHPO 713(SEQ ID NO: 518), GHPO 716(SEQ ID NO: 520), GHPO718(SEQ ID NO: 522), GHPO 726(SEQ ID NO: 524), GHPO 734(SEQ ID NO: 526), GHPO 740(SEQ ID NO: 528), GHPO 770(SEQ ID NO: 530), GHPO782(SEQ ID NO: 532), GHPO 786(SEQ ID NO: 534), GHPO 792(SEQ ID NO: 536), GHPO 797(SEQ ID NO: 538), GHPO 816(SEQ ID NO: 540), GHPO828(SEQ ID NO: 542), GHPO 839(SEQ ID NO: 544), GHPO 840(SEQ ID NO: 546), GHPO 842(SEQ ID NO: 548), GHPO 550 (SEQ ID NO: 885), GHPO889(SEQ ID NO: 552), GHPO 903(SEQ ID NO: 554), GHPO 912(SEQ ID NO: 556), GHPO 946(SEQ ID NO: 558), GHPO 958(SEQ ID NO: 560), GHPO968(SEQ ID NO: 562), GHPO 987(SEQ ID NO: 564), GHPO 992(SEQ ID NO: 566), GHPO 996(SEQ ID NO: 568), GHPO 997(SEQ ID NO: 570), GHPO1002(SEO ID NO: 572), GHPO 1026(SEQ ID NO: 574), GHPO 1028(SEQ ID NO: 576), GHPO1034(SEQ ID NO: 578), GHPO 1038(SEQ ID NO: 580), GHPO 1059(SEQ ID NO:582), GHPO 1065(SEQ ID NO: 584), GHPO 1072(SEQ ID NO: 586), GHPO 1073(SEQ ID NO: 588), GHPO 1088(SEQ ID NO: 590), GHPO 1(SEQ ID NO: 109592), GHPO 1105(SEQ ID NO: 594), GHPO 1115(SEQ ID NO: 596), GHPO 1159(SEQ ID NO: 598), GHPO 1177(SEQ ID NO: 600), GHPO 1187(SEQ ID NO: 602), GHPO 1192(SEQ ID NO: 604), GHPO 1195(SEQ ID NO: 606), GHPO 1224(SEQ ID NO: 608), GHPO 1225(SEQ ID NO: 610), GHPO 1228(SEQ ID NO: 612), GHPO 1229(SEQ ID NO: 614), GHPO 1231(SEQ ID NO: 616), GHPO 1236(SEQ ID NO: 618), GHPO 1242(SEQ ID NO: 620), GHPO 1248(SEQ ID NO: 622), GHPO 1270(SEQ ID NO: 624), GHPO 1271(SEQ ID NO: 626), GHPO 1298(SEQ ID NO: 628), GHPO (SEQ ID NO: 1304), GHPO (SEQ ID NO: 630), GHPO 1304(SEQ ID NO: 632, GHPO 1315(SEQ ID NO: 1315), GHPO 1319(SEQ ID NO: 636), GHPO 1323(SEQ ID NO: 638), GHPO 1331(SEQ ID NO: 640), GHPO 1332(SEQ ID NO: 642), GHPO 1347(SEQ ID NO: 644), GHPO 1373(SEQ ID NO: 646), GHPO 1376(SEQ ID NO: 648), GHPO 1380(SEQ ID NO: 650), GHPO 1394 PO 1394(SEQ ID NO: 652), GHPO 1407(SEQ ID NO: 654), GHPO 5(SEQ ID NO: 141141141656), GHPO 1425(SEQ ID NO: 658), GHPO 1427(SEQ ID NO: 660), GHPO 1444(SEQ ID NO: 662), GHPO 1449(SEQ ID NO: 664), GHPO 1465(SEQ ID NO: 666), GHPO 1475(SEQ ID NO: 668), GHPO 1479(SEQ ID NO: 670), GHPO 1483(SEQ ID NO: 1483), GHPO 674 (SEQ ID NO: 674), GHPO 674 (SEQ ID NO: 672), GHPO 1496(SEQ ID NO: 149676), GHPO 1524(SEQ ID NO: 678), GHPO 1536(SEQ ID NO: 680), GHPO 1539(SEQ ID NO: 682), GHPO 1540(SEQ ID NO: 684), GHPO 1542(SEQ ID NO: 686), GHPO 1555(SEQ ID NO: 688), GHPO 1560(SEQ ID NO: 690), GHPO 1564(SEQ ID NO: 692), GHPO 1570(SEQ ID NO: 694), GHPO 1588(SEQ ID NO: 696), GHPO 1604(SEQ ID NO: 698), GHPO 1605(SEQ ID NO: 700), GHPO 1619(SEQ ID NO: 702), GHPO 1629(SEQ ID NO: 704: 718), GHPO 1642(SEQ ID NO: 706), GHPO 1654(SEQ ID NO: 708), GHPO 1661(SEQ ID NO: 710), GHPO 1673(SEQ ID NO: 712), GHPO 1687(SEQ ID NO: 16892), GHPO 15392 (SEQ ID NO: 16993), GHPO 16993), GHPO 1699(SEQ ID NO: 720), GHPO 1738(SEQ ID NO: 722), GHPO 1745(SEQ ID NO: 724), GHPO 1746(SEQ ID NO: 726), GHPO 1754(SEQ ID NO: 728), GHPO 1792(SEQ ID NO: 730), GHPO 1795(SEQ ID NO: 732), GHPO 1796(SEQ ID NO: 734), GHPO 7(SEQ ID NO: 736), GHPO 8(SEQ ID NO: 738), GHPO 9(SEQ ID NO: 740), GHPO10 (SEQ ID NO: 742), GHPO12 (SEQ ID NO: 744), GHPO25(SEQ ID NO: 746), GHPO27 (SEQ ID NO: 748), GHPO 29(SEQ ID NO: 750), GHPO30 (SEQ ID NO: 752), GHPO 37(SEQ ID NO: 754), GHPO49(SEQ ID NO: 756), GHPO51 (SEQ ID NO: 758), GHPO54 (SEQ ID NO: 760), GHPO65 (SEQ ID NO: 762), GHPO 66(SEQ ID NO: 764), GHPO68(SEQ ID NO: 766), GHPO70 (SEQ ID NO: 768), GHPO 77(SEQ ID NO: 770), GHPO83 (SEQ ID NO: 772), GHPO 85(SEQ ID NO: 774), GHPO87(SEQ ID NO: 776), GHPO 91(SEQ ID NO: 778), GHPO 92(SEQ ID NO: 780), GHPO96 (SEQ ID NO: 782), GHPO 97(SEQ ID NO: 784), GHPO111(SEQ ID NO: 786), GHPO 115(SEQ ID NO: 788), GHPO117 (SEQ ID NO: 790), GHPO 123(SEQ ID NO: 792), GHPO 124(SEQ ID NO: 794), GHPO126(SEQ ID NO: 796), GHPO127 (SEQ ID NO: 798), GHPO 128(SEQ ID NO: 800), GHPO 131(SEQ ID NO: 802), GHPO 133(SEQ ID NO: 804), GHPO140(SEQ ID NO: 806), GHPO141 (SEQ ID NO: 808), GHPO 145(SEQ ID NO: 810), GHPO 147(SEQ ID NO: 812), GHPO 166(SEQ ID NO: 814), GHPO181(SEQ ID NO: 816), GHPO 187(SEQ ID NO: 818), GHPO 188(SEQ ID NO: 820), GHPO 192(SEQ ID NO: 822), GHPO 202(SEQ ID NO: 824), GHPO204(SEQ ID NO: 826), GHPO 205(SEQ ID NO: 828), GHPO 212(SEQ ID NO: 830), GHPO 218(SEQ ID NO: 832), GHPO 226(SEQ ID NO: 834), GHPO231(SEQ ID NO: 836), GHPO 236(SEQ ID NO: 838), GHPO 239(SEQ ID NO: 840), GHPO 245(SEQ ID NO: 842), GHPO 246(SEQ ID NO: 844), GHPO248(SEQ ID NO: 846), GHPO 253(SEQ ID NO: 848), GHPO 265(SEQ ID NO: 850), GHPO 266(SEQ ID NO: 852), GHPO 271(SEQ ID NO: 854), GHPO272(SEQ ID NO: 856), GHPO 286(SEQ ID NO: 858), GHPO 291(SEQ ID NO: 860), GHPO 292(SEQ ID NO: 862), GHPO 297(SEQ ID NO: 864), GHPO304(SEQ ID NO: 866), GHPO 307(SEQ ID NO: 868), GHPO 324(SEQ ID NO: 870), GHPO 326(SEQ ID NO: 872), GHPO 331(SEQ ID NO: 874), GHPO343(SEQ ID NO: 876), GHPO 345(SEQ ID NO: 878), GHPO 346(SEQ ID NO: 880), GHPO 352(SEQ ID NO: 882), GHPO 355(SEQ ID NO: 884), GHPO363(SEQ ID NO: 886), GHPO 886(SEQ ID NO: 88888), GHPO 376(SEQ ID NO: 890), GHPO 378(SEQ ID NO: 892), GHPO 388(SEQ ID NO: 894), GHPO396(SEQ ID NO: 896), GHPO 403(SEQ ID NO: 898), GHPO 410(SEQ ID NO: 900), GHPO 415(SEQ ID NO: 902), GHPO 421(SEQ ID NO: 904), GHPO439(SEQ ID NO: 906), GHPO 441(SEQ ID NO: 908), GHPO 443(SEQ ID NO: 910), GHPO 453(SEQ ID NO: 912), GHPO 455(SEQ ID NO: 914), GHPO464(SEQ ID NO: 916), GHPO 467(SEQ ID NO: 918), GHPO 468(SEQ ID NO: 920), GHPO 470(SEQ ID NO: 922), GHPO (SEQ ID NO: 924), GHPO487(SEQ ID NO: 926), GHPO 928 (SEQ ID NO: 488), GHPO 9(SEQ ID NO: 48930), GHPO 930, GHPO 932: 932), GHPO 501(SEQ ID NO: 934), GHPO504(SEQ ID NO: 936), GHPO 512(SEQ ID NO: 938), GHPO 517(SEQ ID NO: 940), GHPO 520(SEQ ID NO: 942), GHPO 528(SEQ ID NO: 944), GHPO530(SEQ ID NO: 946), GHPO 532(SEQ ID NO: 948), GHPO 548(SEQ ID NO: 950), GHPO 561(SEQ ID NO: 952), GHPO 564(SEQ ID NO: 954), GHPO572(SEQ ID NO: 956), GHPO 573(SEQ ID NO: 958), GHPO 574(SEQ ID NO: 960), GHPO 577(SEQ ID NO: 972), GHPO 579(SEQ ID NO: 964), GHPO583(SEQ ID NO: 966), GHPO 588(SEQ ID NO: 968), GHPO 593(SEQ ID NO: 970), GHPO 597(SEQ ID NO: 972: 598), GHPO 598(SEQ ID NO: 97594), GHPO604(SEQ ID NO: 976), GHPO 606(SEQ ID NO: 978), GHPO 611(SEQ ID NO: 980), GHPO 612(SEQ ID NO: 982), GHPO 615(SEQ ID NO: 984), GHPO632(SEQ ID NO: 986), GHPO 633(SEQ ID NO: 988), GHPO 637(SEQ ID NO: 990), GHPO 651(SEQ ID NO: 992), GHPO 663(SEQ ID NO: 994), GHPO (SEQ ID NO: 996), GHPO 693(SEQ ID NO: 998), GHPO 698(SEQ ID NO: 1000), GHPO 703(SEQ ID NO: 1002), GHPO 704(SEQ ID NO: 1004), GHPO 705(SEQ ID NO: 1006), GHPO 707 PO (SEQ ID NO: 1008), GHPO 721 PO (SEQ ID NO: 1010), GHPO 727(SEQ ID NO: 1012), GHPO 728(SEQ ID NO: 728), GHPO 1014 NO: 1014), GHPO 758(SEQ ID NO: 1018), GHPO 763(SEQ ID NO: 1020), GHPO 771(SEQ ID NO: 1022), GHPO 774(SEQ ID NO: 1024), GHPO 776(SEQ ID NO: 1026), GHPO 783(SEQ ID NO: 1028), GHPO 800(SEQ ID NO: 1030), GHPO 806(SEQ ID NO: 1032), GHPO 807(SEQ ID NO: 1034), GHPO (SEQ ID NO: 1036), GHPO 809(SEQ ID NO: 1038), GHPO 811(SEQ ID NO: 1040), GHPO 815(SEQ ID NO: 1042), GHPO 819(SEQ ID NO: 1044), GHPO 841(SEQ ID NO: 1046), GHPO 843(SEQ ID NO: 1048), GHPO 846(SEQ ID NO: 8921050), GHPO 875(SEQ ID NO: 1052), GHPO (SEQ ID NO: 1054), GHPO (SEQ ID NO: 1056), GHPO 768), GHPO 906(SEQ ID NO: 1060), GHPO 908(SEQ ID NO: 1062), GHPO 921(SEQ ID NO: 1064), GHPO 923(SEQ ID NO: 1066), GHPO 926(SEQ ID NO: 1068), GHPO 933(SEQ ID NO: 1070), GHPO 939(SEQ ID NO: 1072), GHPO 940(SEQ ID NO: 1074), GHPO 943(SEQ ID NO: 1076), GHPO 951(SEQ ID NO: 1078), GHPO 961(SEQ ID NO: 1080), GHPO 965(SEQ ID NO: 1082), GHPO 990(SEQ ID NO: 1084), GHPO 991(SEQ ID NO: 1086), GHPO 998(SEQ ID NO: 1088), GHPO 1001(SEQ ID NO: 1098), GHPO 1090(SEQ ID NO: 1092), GHPO1033(SEQ ID NO: 1094), GHPO 9(SEQ ID NO: 1046), GHPO 1001(SEQ ID NO: 1098), GHPO 1100 (SEQ ID NO: 1098), GHPO 1091100), GHPO 1044(SEQ ID NO: 1102), GHPO 1051(SEQ ID NO: 1104), GHPO 1058(SEQ ID NO: 1106), GHPO 1060(SEQ ID NO: 1108), GHPO 1075(SEQ ID NO: 1110), GHPO1077(SEQ ID NO: 1112), GHPO 1082(SEQ ID NO: 1114), GHPO 1083(SEQ ID NO: 1116), GHPO 1086(SEQ ID NO: 1118), GHPO 1087(SEQ ID NO: 1120), GHPO 1090(SEQ ID NO: 1122), GHPO 1097(SEQ ID NO: 1124), GHPO 1098(SEQ ID NO: 1126), GHPO 1103(SEQ ID NO: 1128), GHPO1113(SEQ ID NO: 1130), GHPO (SEQ ID NO: 1132), GHPO 3(SEQ ID NO: 1134), GHPO 1116(SEQ ID NO: 11256), GHPO 1129(SEQ ID NO: 1138), GHPO 1130(SEQ ID NO: 1130), GHPO 1140), GHPO 4(SEQ ID NO: 1142), GHPO 1161(SEQ ID NO: 1144), GHPO 1166(SEQ ID NO: 1146), GHPO1170(SEQ ID NO: 1148), GHPO 1175(SEQ ID NO: 1150), GHPO 1181(SEQ ID NO: 1152), GHPO 1186(SEQ ID NO: 1154), GHPO 1188(SEQ ID NO: 1156), GHPO 1191(SEQ ID NO: 1158), GHPO 1193(SEQ ID NO: 1160), GHPO 1196(SEQ ID NO: 1162), GHPO 1204(SEQ ID NO: 1164), GHPO1210(SEQ ID NO: 1166), GHPO 1211(SEQ ID NO: 1168), GHPO 1216(SEQ ID NO: 1170), GHPO 1218(SEQ ID NO: 1172), GHPO 1220(SEQ ID NO: 1174), GHPO 1223(SEQ ID NO: 1176), GHPO 1226(SEQ ID NO: 1178), GHPO 1240(SEQ ID NO: 1240), GHPO 1186(SEQ ID NO: 1181251), GHPO 1254), GHPO 1252(SEQ ID NO: 1186), GHPO 1261(SEQ ID NO: 1188), GHPO 1265(SEQ ID NO: 1190), GHPO 1267(SEQ ID NO: 1192), GHPO 1278(SEQ ID NO: 1194), GHPO 1282(SEQ ID NO: 1196), GHPO 1283(SEQ ID NO: 1198), GHPO 1287(SEQ ID NO: 1200), GHPO1292(SEQ ID NO: 1202), GHPO 1293(SEQ ID NO: 1204), GHPO (SEQ ID NO: 1206), GHPO 1309(SEQ ID NO: 1208), GHPO 1317(SEQ ID NO: 1210), GHPO 1318(SEQ ID NO: 1212), GHPO 1321(SEQ ID NO: 1214), GHPO 1325(SEQ ID NO: 1216), GHPO 134PO 1(SEQ ID NO: 1351351222), GHPO 1(SEQ ID NO: 1220), GHPO 1354(SEQ ID NO: 1363), GHPO 1224(SEQ ID NO: 1376), GHPO 1381(SEQ ID NO: 1228), GHPO 1401(SEQ ID NO: 1230), GHPO 1402(SEQ ID NO: 1232), GHPO 1403(SEQ ID NO: 1234), GHPO 1408(SEQ ID NO: 1236), GHPO1416(SEQ ID NO: 1238), GHPO 1420(SEQ ID NO: 1240), GHPO 8(SEQ ID NO: 1242), GHPO 1437(SEQ ID NO: 1244), GHPO 1439(SEQ ID NO: 1246), GHPO 1460(SEQ ID NO: 1248), GHPO 1463(SEQ ID NO: 1250), GHPO 1472(SEQ ID NO: 1252), GHPO 1474(SEQ ID NO: 1254), GHPO1484(SEQ ID NO: 1256), GHPO 1489(SEQ ID NO: 1258), GHPO 1494(SEQ ID NO: 1260), GHPO 5(SEQ ID NO: 1492), GHPO 1498(SEQ ID NO: 1491269), GHPO 1499(SEQ ID NO: 1498), GHPO 1491268), GHPO 1503(SEQ ID NO: 1270), GHPO 1504(SEQ ID NO: 1272), GHPO1510(SEQ ID NO: 1274), GHPO 1518(SEQ ID NO: 1276), GHPO 1533(SEQ ID NO: 1278), GHPO 1541(SEQ ID NO: 1280), GHPO 1544(SEQ ID NO: 1282), GHPO 1548(SEQ ID NO: 1284), GHPO 1565(SEQ ID NO: 1286), GHPO 1575(SEQ ID NO: 1288), GHPO 1582(SEQ ID NO: 1290), GHPO1595(SEQ ID NO: 1292), GHPO 1597(SEQ ID NO: 1294), GHPO 1599(SEQ ID NO: 1296), GHPO 1601(SEQ ID NO: 1298), GHPO 1609(SEQ ID NO: 1300), GHPO 1613(SEQ ID NO: 1631302), GHPO 1614(SEQ ID NO: 1304), GHPO 6(SEQ ID NO: 1310), GHPO 1628(SEQ ID NO: 1629), GHPO 1629(SEQ ID NO: 1308), GHPO 1640(SEQ ID NO: 1312), GHPO 1641(SEQ ID NO: 1314), GHPO 1646(SEQ ID NO: 1316), GHPO 1662(SEQ ID NO: 1318), GHPO 1667(SEQ ID NO: 1320), GHPO 1668(SEQ ID NO: 1322), GHPO 1670(SEQ ID NO: 1324), GHPO 1671(SEQ ID NO: 1326), GHPO1672(SEQ ID NO: 1328), GHPO 8(SEQ ID NO: 1671330), GHPO 1684(SEQ ID NO: 1332), GHPO 1695(SEQ ID NO: 1334), GHPO 1697(SEQ ID NO: 1336), GHPO 1701(SEQ ID NO: 1338), GHPO 1719(SEQ ID NO: 1340), GHPO 1723(SEQ ID NO: 1342), GHPO 2(SEQ ID NO: 1341744), GHPO 1731349 (SEQ ID NO: 1346), GHPO 1341(SEQ ID NO: 1731348), GHPO 1347(SEQ ID NO: 1351359), GHPO 1742 (SEQ ID NO: 1744), GHPO 1750(SEQ ID NO: 1354), GHPO 1751(SEQ ID NO: 1356), GHPO 1755(SEQ ID NO: 1358), GHPO 1771(SEQ ID NO: 1360), GHPO 1786(SEQ ID NO: 1362), and GHPO1789(SEQ ID NO: 1364); or
(ii) Derivatives of said helicobacter polypeptides.
9. A compound according to claim 8 which is a mature form or derivative of the polypeptide encoded by the DNA molecule of claim 4.
10. A compound according to claim 8 which is a mature form or derivative of the polypeptide encoded by the DNA molecule of claim 5.
11. A pharmaceutical composition for the prevention or treatment of helicobacter infection in a mammal, said composition comprising a prophylactically or therapeutically effective amount of a compound according to claim 8, 9, or 10 admixed with a physiologically acceptable diluent or carrier.
12. The compound of claim 11, further comprising an antibiotic, an antisecretory agent, a bismuth salt, or a combination thereof.
13. The composition of claim 12, wherein the antibiotic is selected from the group consisting of: amoxicillin, clarithromycin, tetracycline, metronidazole, and erythromycin.
14. The composition of claim 12 wherein the bismuth salt is selected from the group consisting of: bismuth subcitrate and bismuth subsalicylate.
15. The composition of claim 12, wherein said antisecretory agent is a proton pump inhibitor.
16. The composition of claim 15, wherein the proton pump inhibitor is selected from the group consisting of: omeprazole, lansoprazole, and pantoprazole.
17. The composition of claim 12, wherein the antisecretory agent is H2-a receptor antagonist.
18. The composition of claim 17, wherein said H is2-the receptor antagonist is selected from the group consisting of: ranitidine, cimetidine, famotidine, nizatidine, and roxatidine.
19. The composition of claim 12, wherein the antisecretory agent is a prostaglandin analog.
20. The composition of claim 19, wherein the prostaglandin analog is miroprost or enprostil.
21. The composition of claim 11, further comprising a prophylactically or therapeutically effective amount of a second helicobacter polypeptide or a derivative thereof.
22. The composition of claim 21, wherein the second helicobacter polypeptide is a helicobacter urease, or a subunit or derivative thereof.
23. The composition of claim 11, further comprising an adjuvant.
24. A pharmaceutical composition for preventing or treating helicobacter infection in a mammal, said composition comprising a prophylactically or therapeutically effective amount of the polynucleotide of claim 1 or 2 admixed with a physiologically acceptable diluent or carrier.
25. A pharmaceutical composition for preventing or treating helicobacter infection in a mammal, said composition comprising a prophylactically or therapeutically effective amount of the polynucleotide of claim 4, 5, or 6 admixed with a physiologically acceptable diluent or carrier.
26. A pharmaceutical composition for preventing or treating helicobacter infection in a mammal, said composition comprising a prophylactically or therapeutically effective amount of the polynucleotide of claim 7 admixed with a physiologically acceptable diluent or carrier.
27. A composition comprising a viral vector having inserted in its genome the DNA molecule of claim 3, said DNA molecule being placed under conditions for expression in mammalian cells, and said viral vector being admixed with a physiologically acceptable diluent or carrier.
28. The composition of claim 27, wherein the viral vector is a poxvirus.
29. A composition comprising a bacterial vector comprising the DNA molecule of claim 3, said DNA molecule being placed under conditions for expression, and said bacterial vector being admixed with a physiologically acceptable diluent or carrier.
30. The composition of claim 29, wherein the carrier is selected from the group consisting of: shigella, Salmonella, Vibrio cholerae, Lactobacillus, Bacillus Calmette-Guerin, and Streptococcus.
31. The composition of claim 24, wherein the polynucleotide is a DNA molecule inserted into a plasmid that is incapable of replication and of substantial integration into a mammalian genome and is placed under conditions for expression in a mammalian cell.
32. An expression cassette comprising the DNA molecule of claim 3 placed under conditions for expression in a prokaryotic or eukaryotic cell.
33. A method for producing a compound of claim 8, comprising culturing a prokaryotic or eukaryotic cell transformed or transfected with an expression cassette of claim 32, and recovering the compound from the cell culture.
34. A pharmaceutical composition for preventing or treating helicobacter infection in a mammal, said composition comprising a prophylactically or therapeutically effective amount of an antibody that binds to a compound of claim 8, 9, or 10 in admixture with a physiologically acceptable diluent or carrier.
CN98805612A 1997-04-01 1998-04-01 Identification of polynucleotides encoding novel helicobacter polypeptides in helicobacter genome Pending CN1263436A (en)

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US83345797A 1997-04-01 1997-04-01
US08/833,457 1997-04-01
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US08/881,227 1997-06-24
US90261597A 1997-07-29 1997-07-29
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CN112194706B (en) * 2020-09-30 2022-03-08 广州派真生物技术有限公司 Adeno-associated virus mutant and application thereof
CN118063569A (en) * 2024-04-24 2024-05-24 上海金翌生物科技有限公司 Helicobacter pylori secretory protein and application thereof in helicobacter pylori detection
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