CN1262097A - Compound iron ammonium citrate preparation - Google Patents

Abstract

A compound iron ammonium citrate preparation for preventing and treating anemia of baby and juvenile is prepared from ferric ammonium citrate, honey, single roxburgh rose fruit juice and distilled water. Its advantages are simple preparing process, widely available raw materials and low cost.

Description

Compound iron ammonium citrate preparation

The present invention relates to a kind of compound iron ammonium citrate preparation, be particularly useful for the treatment and the prevention of child and teenager anemia and occult anemia.

Baby's monthly age is after four months, because growth promoter is accelerated, requirement to ferrum increases, but this moment, baby's staple food people milk or milk iron-holder were very low, rice and flour are stuck with paste or other milk replacer feeds that then ferrum is more inadequate, add and exhaust from the ferrum that mother obtains viviparous period, so iron deficiency anemia very easily takes place.If be subjected to the influence of premature labor, polyembryony or various diseases, ferrum store to be reduced, malabsorption or lose has too much more increased the weight of the generation of iron deficiency anemia.At child and adolescence, be that physical ability is grown and critical period of intellectual development, unreasonable as the food collocation, add factors such as particular about food, monophagia, snacks be too much, very easily cause iron deficiency.If add the influence of disease, common as the repeated infection disease, parasitic disease etc. can increase the weight of the loss of ferrum.The teenager sexual development shifts to an earlier date at present, and girl's menarche is much since about 12 years old, more needs competent ferrum to wait to replenish.Therefore iron deficiency anemia is seriously influencing infant and teen-age health; can cause resistance to lower; the normal infectious disease of suffering from; common inappetence; further increased the weight of absorption obstacle to various nutrient substance; often show dysphoria or dispirited in spirit, absent minded in the learning process, hypomnesis.Intelligence is lower than the child of the same age more, above situation, very easily to ignore when not obvious how and to rescue because of severity of anemia, anemia just has iron deficiency state before taking place, claim recessive iron deficiency, report according to " the clinical department of pediatrics magazine in North America ", U.S. children iron deficiency anemia sickness rate is 24%, recessive iron deficiency sickness rate is up to 68%, the domestic scholar of having does further inspection to the children's that 646 hemoglobin normally are regarded as not having anemia, and finding has 17.8% people to have iron deficiency, so numerous recessive iron deficiency child and teenager, as can not get replenishing of ferrum, the easiest anemia that becomes.Make many children and teenager can not get timely treatment, incured loss through delay normal growth promoter and intellectual development.Child and the teenager iron deficiency anemia incidence rate height fast at growth promoter have been subjected to extensive attention, according to reported in literature, both at home and abroad the relevant expert all advocates behind baby due and to begin promptly should replenish chalybeate in four month, and after finding in time to replenish chalybeate, infant development index D Q is significantly improved (DQ=developmental age/growth age * 100), thereby can invigorate health effectively and the raising of intelligence.At this kind situation, World Health Organization's suggestion, the child and the teenager of commute generation iron deficiency anemia all should suitably replenish chalybeate, and proposition per kilogram of body weight every day only need give 2 mg element ferrum.At present infant and teenager absorb ferrum from food, are important sources, although be rich ferrum food, the absorption of human body amount is limited, as being about 1% only to the iron absorptivity in the vegetable food, in the animal food absorbance of ferrum also difficulty reach 20%.A kind of is ferrous sulfate, contains 200 milligrams of elemental irons, and the absorbance height is inexpensive, but gastrointestinal reaction is heavy, and hinder for a long time and take: another kind is a ferrous porphyrin, the absorbance height, and from the hemoglobin of animal blood, but the cost height should not be extensive use of; Planting is ferrous fumarate again, 300 milligrams of iron content, but gastrointestinal irritation is heavy; The 4th kind of Ferrous gluconate belong to ferrous iron, but iron-holder is low, and only 110 milligrams, and gastrointestinal irritation is arranged; The 5th kind is iron dextran, injection only, and untoward reaction is heavy, only uses for special circumstances.

The objective of the invention is the problem at above-mentioned existence, a kind of compound iron ammonium citrate preparation is provided, utilize fructose and vitamin C anti-former, technology is simple, and is easy to implement the method, thereby improved infant and teen-age body constitution and intelligence.

In order to achieve the above object, the present invention adopts following technical measures: adopt chalybeate, Mel, Sucus Rosae Normalis, distilled water.Chalybeate is ferric ammonium citrate, and is soluble in water, stable in properties, and gastrointestinal irritation is little, and for transferring ferric iron to ferrous iron, with fructose and vitamin reduction, 25 milligrams of vitamin Cs can make ferrum absorb at double.Mainly contain fructose in the Mel, Vitamin C content is the hat in the fruit in the Fructus Rosae Normalis, reaches 840-3540 milligram/100 grams, and Mel and Fructus Rosae Normalis still contain the multiple nutrients material.It is characterized in that ferric ammonium citrate, Mel, Sucus Rosae Normalis, distilled water all by a certain percentage the system join, just obtain a kind of compound iron ammonium citrate preparation.

The present invention compared with prior art, have the following advantages: can effectively correct infant and teenager iron deficiency anemia, health invigorating, increase intelligence, the raw material wide material sources, inexpensive, technology is simple, easy to implement the method, taking convenience is particularly useful for the treatment and the prevention of infant, teenager anemia, has society and economic benefit widely.Concrete dosage following (instructions of taking: weekly):

Age (year)	Infant each (ml)	Mother each (ml)	Amount to (ml)
				??0.5-1	???????1	??????9	????10
???2-3	??????1.5	?????8.5	????10
				???4-6	???????2	??????8	????10
???7-12	???????5	??????5	????10

Embodiment 1

Adopt ferric ammonium citrate 10-15%, Mel 5-8%, Sucus Rosae Normalis 20%, distilled water 60-62%, behind the mix homogeneously, just obtain compound iron ammonium citrate preparation.Embodiment 2

Adopt ferric ammonium citrate 11%, Mel 8%, Sucus Rosae Normalis 20%, distilled water 61%, behind the mix homogeneously, just obtain compound iron ammonium citrate preparation.Embodiment 3

Adopt ferric ammonium citrate 12%, Mel 6%, Sucus Rosae Normalis 20%, distilled water 62%, just obtain compound iron ammonium citrate preparation behind the mix homogeneously.Embodiment 4

Adopt ferric ammonium citrate 15%, Mel 5%, Sucus Rosae Normalis 20%, distilled water 60%, just obtain compound iron ammonium citrate preparation behind the mix homogeneously.

Claims (2)

1, a kind of compound iron ammonium citrate preparation is characterized in that ferric ammonium citrate, Mel, Sucus Rosae Normalis, distilled water are made by a certain percentage to join.

2, a kind of compound iron ammonium citrate preparation according to claim 1 is characterized in that:

Ferric ammonium citrate 10-15%

Mel 5-8%

Sucus Rosae Normalis 20%

Distilled water 60-62%.