CN100386075C

CN100386075C - Medicine capable of promoting height elevation and formulation thereof

Info

Publication number: CN100386075C
Application number: CNB2005100616090A
Authority: CN
Inventors: 吴福同; 王永新; 吴伟; 杨勇
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-11-18
Filing date: 2005-11-18
Publication date: 2008-05-07
Anticipated expiration: 2025-11-18
Also published as: CN1799538A

Abstract

The present invention relates to a medicine capable of promoting the height elevation of a human body and a preparation thereof. The effective components of the medicine is composed of gamma-amino butyric acid and L-lysine, wherein the weight ratio of the gamma-amino butyric acid to the L-lysine is from 1:0.3 to 1:3. In addition, the present invention also provides the preparation of the medicine. The product of the present invention directly excites and promotes the augmented secretion of growth hormone releasing hormones of the nerve center of the hypothalamus so that the augmented secretion of growth hormones of the pituitary is further stimulated, which is the maximal diversity and the maximal difference among the product of the present invention and other so-called medicines for promoting height elevation. The present invention has the advantages of convenient administration, safety and economy.

Description

A kind of medicine and preparation thereof that can promote that human body grows tall

Technical field

The present invention relates to a kind of medicine and preparation thereof that can promote that human body grows tall.

Background technology

Along with the progress of society and constantly increasing of human height, it is important that this speech of height has more and more seemed in people's mind, so far it has been not only children and has weighed whether healthy standard, and be adult's (particularly youngster) important in aesthetic, simultaneously recruit student, advertise for workers, recruit cadres, conscript, obtain employment or even men and women falling in love in the society especially, one of essential condition in the marriage, for this reason, this makes some pygmies worried to the greatest extent difficult.

Cause short reason a lot, as direct heredity cause short and small, it is short and small that the short and small and disease of pituitary gland that hour retarded growth causes causes etc., but if converge the situation of combining them, get to the bottom of it the source of asking on earth, much all be since child's body inner growth hormone hyposecretion, low and content cross hang down due to.Therefore how to manage to improve child's growth hormone secretion ability and improve their intravital level of growth hormone, this will be to promote child to grow tall and the important measures of growing tall fast.

Growth hormone: this is a kind of hormone that self exists in child's body originally, and it is secreted by anterior pituitary, is regulated by growth hormone releasing hormone and Somat, and the growth promoter that it is responsible for child especially grows tall.Growth hormone this be the most critical, the most important a kind of hormone that promote child to grow tall, be basic.If its secretion is sufficient, then child just looks soon, looks high.If opposite hyposecretion or lack as, then nature will look slow, and will be long not high, severe patient even be the dwarf.How to manage to improve the growth hormone secretion ability of child's hypophysis for this reason and improve their intravital level of growth hormone, this will be the important thing that vast researcher is looked for.

Look back the treatment of China's past to cretinism, (except that the injection recombinant human somatropin) still do not find a kind of conscientiously and effectively medicine and method so far.Therefore, this still is stuck on the other degree that pushes away of primary flank attack most treatments, as with some zinc supplements, replenish the calcium, replenish the thing of some vitamin or aminoacid and so on, though these have certain benefit to human body raising body constitution, but it is to growing tall the practical no much effects of saying so.

As for several years ago studying successful injection recombinant human somatropin both at home and abroad, this is the right way, be at all, be an important breakthrough on science and technology, and be an important creativity and innovation.It has solved people's the problem of growing tall greatly.But it also has deficiency, and promptly it must be injected every day, can not be oral, and not only misery but also bother.The 2nd, cost an arm and a leg (need change the money about 120-180 unit every day, logotype 3 months to 1 year or several years, that expense just has not been easy to make commentary), majority can not use.

Summary of the invention

In order to solve above-mentioned technical problem, the purpose of this invention is to provide a kind of easily and effectively, safe, economical can promote the medicine that human body grows tall.

This aspect another one purpose provides the preparation of this medicine.

In order to realize above-mentioned purpose, the present invention has adopted following technical scheme;

A kind of medicine that can promote that human body grows tall is characterized in that the effective ingredient of this medicine comprises γ-An Jidingsuan.

As preferably, this medicine also comprises L-lysine, and wherein the part by weight of γ-An Jidingsuan and L-lysine is 1: 0.3～1: 2.

As preferred again, the part by weight of γ-An Jidingsuan and L-lysine is 1: 0.5～1: 2.

As most preferably, the part by weight of γ-An Jidingsuan and L-lysine is 1: 1.

A kind of preparation that can promote the medicine that human body grows tall comprises γ-An Jidingsuan, L-lysine and pharmaceutically useful carrier.As preferably, said preparation is tablet, capsule, granule or soft capsule.

γ-An Jidingsuan of the present invention is a nervus centralis media, can pass through blood brain barrier, content is very high in brain, can excite and promote arc nuclear of hypothalamus and ventromedial nucleus, increase secretion growth hormone releasing hormone (GHRH), thereby excite hypophysis to increase secretion growth hormone (GH).On the other hand, γ-An Jidingsuan can also activate the metabolism of glucose phosphate esterase in the brain, promotes the biosynthesis of acetylcholine, reduces blood ammonia, promotes cerebrum metabolism, recovers function of brain cell.Moreover acetylcholine also can suppress the secretion of Somat, thereby influences and promotion hypophysis increase secretion growth hormone with above-mentioned two aspects.

L-lysine, it is one of essential amino acid, it to the absorption of human body protein, utilize and keep nitrogen budgets and have important function, it can urge gastric secretion, appetite stimulator, raise immunity, simultaneously can also pass through blood brain barrier, enter cerebral tissue, in the mitochondrion of brain cell, degraded produces S-acetyl-coenzyme-A.S-acetyl-coenzyme-A then is the precursor of nerve conduction chemical mediators such as acetylcholine and γ-An Jidingsuan, these mediators are to regulating and improving brain function and promote the secretion of growth hormone releasing hormone to play an important role, so above-mentioned two medicines share, can further promote hypophysis to increase the secretion growth hormone.

Beneficial effect of the present invention is as follows:

1, the present invention can directly excite with promoting the hypothalamus nerve centre increases the secretion growth hormone releasing hormone, thereby (this is recent new discovery further to stimulate hypophysis to increase the secretion growth hormone, be that domestic and international other drug is not seen or rare), also be maximum difference and difference with other so-called medicines that promote to grow tall.

2, convenient (because of it is a tablet, can be oral, can be going along with, can take for a long time, not influenced by gastrointestinal simultaneously or destroy).

3, safety (this product does not have obvious toxicity, side effect, and no great untoward reaction).

4, economical (this product is cheap, can promote the use of in broad masses).

5, this medicine can be taken repeatedly for a long time and repeatedly.(can take in one day 3～4 times) can impel to form a plurality of growth hormone secretions peak, and this more helps growing tall.

The specific embodiment

A kind of medicine that can promote that human body grows tall, its active ingredient are γ-An Jidingsuan and L-lysine.This product is a compound tablet, and every contains each 250 milligrams of above-mentioned former medicines.

Above-mentioned γ-An Jidingsuan compositions is given than behind oral 1 gram of lattice Canis familiaris L., and is rapid through gastrointestinal absorption, reaches the highest blood drug level (50ug/ml) after 1 hour, and the back combines with blood ammonia, is reduced to carbamide rapidly, excretes, and 24 little backs disappear.

Above-mentioned γ-An Jidingsuan compositions is used for the multiple cretinism of children, and retarded growth and growth retardation etc. promote to grow tall, grow tall and grow tall soon, also can be used for multiple brain injury, promote cerebrum metabolism, recover function of brain cell.Helpful to improving intelligence and memory reinforcing.

(usage and dosage) is oral.Children: a 2-4 sheet, 3 times on the one.Or follow the doctor's advice.

Accidental burning sensation after (untoward reaction) medication is felt sick, dizziness, insomnia, constipation, diarrhoea.

(taboo) forbids this product allergy sufferers.Hyperchloremia acidosis and renal insufficiency person fill out usefulness.

(points for attention): forbidding when this product character changes.

(drug interaction): this product two medicines have mutual synergism, and are still indeterminate with other drug.

(overdose): movement disorder, myasthenia, blood pressure reduction, respiration inhibition can appear in heavy dose.

(specification): 0.5 gram.

(storage): shading, sealing is preserved at the drying place.

(packing): 100 slices/bottle.

(effect duration): tentative 2 years.

The present invention compares with similar or class like product: (seeing Table)

Title	The present invention	Injection recombinant human somatropin	Increase intelligence and encourage clever sheet	Strong spirit encourages brilliant
Title	The present invention	Injection recombinant human somatropin	Increase intelligence and encourage clever sheet	Strong spirit encourages brilliant	Main Ingredients and Appearance	γ-An Jidingsuan L-lysine	The recombinant human somatropin	Trace element zinc/lysine vitamin E	Lysine calcium phosphate
Dosage form and content	Every in tablet contains each 250 milligrams of medicine-feedings	Injection contains recombinant human somatropin 4IU for every bottle	Tablet, every contains zinc, and E is an amount of for the lysine dimension	Granule whenever comprises lysine 0.5 gram	Main Ingredients and Appearance	γ-An Jidingsuan L-lysine	The recombinant human somatropin	Trace element zinc/lysine vitamin E	Lysine calcium phosphate

Route of administration and consumption	3 times on the oral one each 2-4 sheets	Subcutaneous injection once a day, each 4-6IU	3 times on the oral one each 4-6 sheets	The each bag of an oral twice-daily
Route of administration and consumption	3 times on the oral one each 2-4 sheets	Subcutaneous injection once a day, each 4-6IU	3 times on the oral one each 4-6 sheets	The each bag of an oral twice-daily	Effect by way of	Act on hypophysis, promote hypophysis to increase the secretion growth hormone.	Directly act on each tissue of skeleton and whole body	Digestive system metabolic system nervous system and growth promoter	Digestive system metabolic system nervous system and growth promoter
Effect	Promoting child to grow tall grows tall again	Promoting child to grow tall grows up	Promote appetite, strengthen digestion and promote protein synthesis	Promote appetite, strengthen digestion and promote protein synthesis	Effect by way of		Directly act on each tissue of skeleton and whole body
Effect	Promoting child to grow tall grows tall again	Promoting child to grow tall grows up			Indication	Multiple cretinism and various poor growth, undergrowth	Treat multiple cretinism dwarfism etc.	Monophagia and anorexia, inappetence, poor growth undergrowth	Monophagia and anorexia, inappetence, poor growth undergrowth
With back GRH test (notes)	Sound response was all arranged after the medication in 30 minutes 60 minutes 90 minutes	Do not have	Do not have	Do not have	Indication	Multiple cretinism and various poor growth, undergrowth	Treat multiple cretinism dwarfism etc.
With back GRH test (notes)		Do not have	Do not have	Do not have	Administration time	As long as epiphysis is not closed, but prolonged application	As long as epiphysis is not closed, but prolonged application	Can take for a long time as long as need	Can take for a long time as long as need
Promote to grow tall effect	Use 1 monthly average can grow tall about 1 centimetre	Use 1 monthly average can grow tall about 1 centimetre	Can suitably improve and grow tall but not obvious	Can suitably improve and grow tall but not obvious	Administration time			Can take for a long time as long as need	Can take for a long time as long as need

Annotate: GRH is the growth hormone releasing hormone stimulation test.

Claims

1. pharmaceutical preparation that can promote that human body grows tall is characterized in that: effective ingredient comprises γ-An Jidingsuan and L-lysine, and wherein the part by weight of γ-An Jidingsuan and L-lysine is 1: 0.3～1: 2, and said preparation also comprises pharmaceutically useful carrier in addition.

2. a kind of pharmaceutical preparation that can promote that human body grows tall as claimed in claim 1 is characterized in that: the part by weight of γ-An Jidingsuan and L-lysine is 1: 0.5～1: 2.

3. a kind of pharmaceutical preparation that can promote that human body grows tall as claimed in claim 2 is characterized in that: the part by weight of γ-An Jidingsuan and L-lysine is 1: 1.

4. as claim 1 or 2 or 3 described a kind of pharmaceutical preparatioies that can promote that human body grows tall, it is characterized in that:

Said preparation is tablet, capsule or granule.

5. as claim 1 or 2 or 3 described a kind of pharmaceutical preparatioies that can promote that human body grows tall, it is characterized in that:

Said preparation is a soft capsule.