CN1259933C - Chinese medicinal composition for treating coronary disease and its preparation and application - Google Patents
Chinese medicinal composition for treating coronary disease and its preparation and application Download PDFInfo
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- CN1259933C CN1259933C CN 200410024102 CN200410024102A CN1259933C CN 1259933 C CN1259933 C CN 1259933C CN 200410024102 CN200410024102 CN 200410024102 CN 200410024102 A CN200410024102 A CN 200410024102A CN 1259933 C CN1259933 C CN 1259933C
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Abstract
The present invention relates to a traditional Chinese medicine composition for treating coronary diseases, which is mainly composed of the following raw materials by weight portions: 2 to 4 portions of common monkshood mother root powder, 5 to 10 portions of asarum herb, 10 to 15 portions of long pepper, 15 to 20 portions of cassia twig, 10 to 15 portions of clove, 20 to 30 portions of chuanxiong rhizome, 15 to 20 portions of safflower, 15 to 20 portions of corydalis tuber, 5 to 10 portions of notoginseng, 30 to 45 portions of astragalus root, 15 to 20 portions of achyranthis root and 3 to 6 portions of borneol. Common coronary heart disease treatment ony use an oral administration traditional Chinese medicine which has the functions of activating blood circulation to dissipate blood stasis, expanding blood vessels, improving cardiac functions and reducing myocardial oxygen consumption. The external-application medicine powder of the present invention also uses various kinds of external-application medicine (achyranthes root, notoginseng, radix aconite, asarum herb, etc.) which is not suitable for (or cautiously used for) oral administration, and the external-application medicine is conventionally used for expelling rheumatism, dispelling cold, easing pain by local anesthesia and alleviating pain. Moreover, the present invention is capable of sending out fragrance and inducing resuscitation. The present invention is traditional Chinese medicine containing volatile oil and has strong penetrating force. The medicines are combined and matched to increase the medical effects, so the present invention achieves the better effects of treating coronary diseases.
Description
Technical field
The invention belongs to the pharmaceutical composition of a kind of prevention and treatment coronary heart disease, be specifically related to a kind of Chinese medicine composition for the treatment of coronary heart disease, also relate to and its production and application.
Background technology
The treatment of coronary heart disease, no matter the traditional Chinese medical science or doctor trained in Western medicine all are by oral or drug administration by injection basically.Its performance curative effect maybe need be passed through gastrointestinal tract; Maybe need pass through blood brain barrier; Or life-time service has different toxic and side effects; Not ideal.
Nitroglycerin with coronary artery dilator was once arranged, made rubber plaster---the nitroderm of similar " SHANGSHI ZHITONG GAO formula ", be applied to patient's pareordia as the dosage form of preventing and treating coronary heart disease; But similar with the situation of rubber plaster, the phenomenon that causes skin allergy is arranged, and make the patient end to use.
Authorization October 28 1992 day for announcing, authorization number be CN1018792B, is called " a kind of manufacture method of preventing and treating the coronary heart disease medicine for external use ", has proposed a kind ofly " can not only treat and can prevent the processing method of the Chinese patent medicine of coronary heart disease by the dermal osmosis effect." Chinese medicine and causing resuscitation with aromatic drugs with blood circulation promoting and blood stasis dispelling, eliminating phlegm dampness removing, blood vessel dilating, cardiac function enhancing, minimizing myocardial oxygen consumption property of medicine; it is strong to walk to scurry power, can go into medicine and Radix Notoginseng powder and Borneolum Syntheticum powder face mixing and stirring that the heart is had one's ideas straightened out and made the expansion of blood capillary battalion.Consumption and manufacture method that it is concrete are as follows: use weight percent meter, get the Radix Scrophulariae of 4.3% (percentage by weight), 5.8% Radix Angelicae Sinensis, 4.3 Semen Cassiae, 4.3% Folium Ginkgo, 4.3% Radix Curcumae, 5.1% Rhizoma Corydalis, 5.1% Flos Carthami, 5.1% Myrrha, 5.1% breast kind, 5.1% Rhizoma Acori Graminei, 5.1% Pericarpium Zanthoxyli, 5.1% Ramulus Cinnamomi, 5.1% Bulbus Allii Macrostemonis, 5.1% Fructus Trichosanthis, 5.1% Radix Codonopsis, 5.1% the Radix Astragali, 5.1% Lignum Dalbergiae Odoriferae, Polygonm multiflorum Thunb Teng of 5.1% is totally 18 flavor Chinese medicines, lower in the warm drying baker, drying is 5 hours under about 50 ℃ Celsius, put sombre dry place after the taking-up cool 5 hours, pulverize through pulverizer then, cross 80 mesh sieves, waste stays powder stand-by; Get 5.4% Borneolum Syntheticum and 5.3% Radix Notoginseng powder and smash the grind up face jointly; At last both mixing and stirring are about to product.
Its thinking is correct, but still has deficiency:
1. the coarse size of medicine was reported 80 mesh sieves according to it;
2. medicine variety is too many, totally 20 kinds;
3. used medicine still is confined to the conventional Chinese medicine category of blood circulation promoting and blood stasis dispelling in the decoct for oral administration.
Summary of the invention
Purpose of the present invention is on the basis of another kind of thinking, and a kind of Chinese medicine composition for the treatment of coronary heart disease that is different from prior art and its production and application is provided.
The technical solution used in the present invention is: develop a kind of Chinese medicine composition for the treatment of coronary heart disease, it is characterized in that mainly being made by the raw material of following components by weight percent:
3～6 parts of 2～4 parts of Radix Aconitis, 5～10 parts of Herba Asaris, 10～15 parts of Fructus Piperis Longi, 15～20 parts of Ramulus Cinnamomi, 10～15 parts of Flos Caryophyllis, 20～30 parts of Rhizoma Chuanxiongs, 15～20 parts on Flos Carthami, 15～20 parts of Rhizoma Corydalis, 5～10 parts of Radix Notoginseng, 30～45 parts of the Radixs Astragali, 15～20 parts of Radix Achyranthis Bidentataes and Borneolum Syntheticums.
Chinese medicine composition of the present invention, wherein the preferred weight component of each raw material is:
3～4 parts of 2～3 parts of Radix Aconitis, 8～10 parts of Herba Asaris, 10～12 parts of Fructus Piperis Longi, 18～20 parts of Ramulus Cinnamomi, 10～12 parts of Flos Caryophyllis, 20～22 parts of Rhizoma Chuanxiongs, 18～20 parts on Flos Carthami, 18～20 parts of Rhizoma Corydalis, 5～7 parts of Radix Notoginseng, 30～35 parts of the Radixs Astragali, 18～20 parts of Radix Achyranthis Bidentataes and Borneolum Syntheticums.
Chinese medicine composition of the present invention, wherein the optimum weight component of each raw material is:
3 parts of 2 parts of Radix Aconitis, 10 parts of Herba Asaris, 10 parts of Fructus Piperis Longi, 20 parts of Ramulus Cinnamomi, 10 parts of Flos Caryophyllis, 20 parts of Rhizoma Chuanxiongs, 20 parts on Flos Carthami, 20 parts of Rhizoma Corydalis, 5 parts of Radix Notoginseng, 30 parts of the Radixs Astragali, 20 parts of Radix Achyranthis Bidentataes and Borneolum Syntheticums.
The dosage form of above-mentioned Pharmaceutical composition is a powder.
The preparation method of the Chinese medicine composition of above-mentioned treatment coronary heart disease takes by weighing above-mentioned all medicines by dosage, inserts and grinds in the apparatus, and porphyrize to epigranular reaches≤74～149 μ m altogether, packs in the gas-pervious textile bag, and it is standby to make the volatile medicine bag.
The application of above-mentioned Pharmaceutical composition in the external pulvis of preparation prevention and treatment coronary heart disease.
According to theory of Chinese medical science, the pathogenesis of coronary heart disease is the thoracic obstruction disease of blood stasis, the stagnation of QI, cold coagulation resistance sun.The present invention uses 12 flavor Chinese medicines altogether, and wherein: monarch is Radix Aconiti, Rhizoma Chuanxiong, Radix Notoginseng in the technical solution of the present invention; Get the effect of its blood circulation promoting and blood stasis dispelling, circulation of qi promoting, cold expelling, pain relieving.Minister is Herba Asari, Fructus Piperis Longi, Ramulus Cinnamomi, Flos Carthami, Rhizoma Corydalis; The effect of except that the power of strengthening monarch drug, also stimulating the menstrual flow with its warming YANG.Assistant is the Radix Astragali, Borneolum Syntheticum; Power with its consolidating superficial resistance and supplementing qi coordinating the actions of various ingredients in a prescription antisepsis and sterilization.Make and be Flos Caryophylli, Radix Achyranthis Bidentatae effect with its causing resuscitation with aromatic drugs circulation of qi promoting inducting the medicines into affected channel.So technical solution of the present invention has fragrance and activates yang benefiting qi and removing blood stasis, the effect of dispersing cold for relieving pain.The external pulvis dosage form can strengthen dose to be increased effect and avoids untoward reaction; The all kinds that can be used for coronary heart disease.
In the technical solution of the present invention:
Radix Aconiti: go into the heart, spleen channel.Wind-damp dispelling, cold expelling, pain relieving.Hot, very toxic.
Modern study, aconitine have local anaesthesia analgesia and antiinflammatory action, can make decreased heart rate, and safety range is little, and be for oral administration suitable careful.
Herba Asari: go into the heart, kidney channel.Hot, warm; Expelling wind and cold, pain relieving, warming the lung to resolve fluid-retention inducing resuscitation.
Modern study contains volatile oil, has analgesia, local anesthetic action, 3 grams that do not surpass for oral administration.
Fructus Piperis Longi: hot, heat, go into the spleen kidney channel.Warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.
Its volatile oil of modern study has obvious antagonism to expeirmental myocardial ischemia, and can prevent multiple tentative arrhythmia.
Ramulus Cinnamomi: hot, sweet, warm.Go into lung, the heart, urinary bladder channel.The diaphoresis expelling pathogenic factors from muscles, warming the meridian for promoting the flow of YANG QI, making the adverse-rising QI downwards.Control anemofrigid cold, rheumatic arthralgia dysmenorrhea, coldness and pain in the epigastrium, amenorrhea, phlegm retention cough with asthma, thoracic obstruction cardiopalmus, renal mass, edema, dysuria.
Modern study: this product volatile oil, main have function of gallbladder promoting, spasmolytic for cinnamic aldehyde, calm, refrigeration function.
Flos Caryophylli: hot, warm.Go into stomach, spleen, kidney channel.Warming middle-JIAO to send down the adverse QI, warming the kidney is supporing yang.
The modern study main component is an eugenol, is aromatic stomachic, strengthens digestion power, alleviates nausea and vomiting.
Rhizoma Chuanxiong: hot, warm.Go into liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, the wind pain relieving of loosing.
Modern study this product contains volatile oil, alkaloid, and cnidium lactone etc. can bring high blood pressure down, and coronary blood flow increasing reduces coronary resistance, suppresses thrombosis and hematoblastic cohesion, and established cohesion piece is had depolymerisation.Alkaloid has anti-acute myocardial ischemia, anoxia functions, and can improve cardiac muscle to anoxybiotic tolerance.
Flos Carthami: hot, warm.Go into the heart, Liver Channel.Promoting blood circulation to restore menstrual flow, the blood stasis removing pain relieving.
Modern study contains carthamin etc., and hypotensive effect is arranged, and extract can increase the coronary flow of Canis familiaris L., improves coronary circulation, and it is relevant to dwindle myocardial infarction area reduction myocardial oxygen consumption, can resist the contraction of myocardium vessel to norepinephrine.
Rhizoma Corydalis: bitter, little suffering, temperature.Go into liver, stomach warp.Invigorate blood circulation, circulation of qi promoting, pain relieving.
Modern study contains multiple alkaloids such as corydalis, and calmness is arranged, analgesic effect, and bring high blood pressure down in addition and antiarrhythmic effect.
Radix Notoginseng: sweet, little hardship, temperature.Go into liver, stomach warp.Hemostasis, dissipating blood stasis, pain relieving.
Modern study contains ginsenoside, arasaponin, flavonoid glycoside, can increase the coronary flow of animal, the coronary flow that the antagonism pituitrin causes reduces and reduces myocardial oxygen consumption, and isolated frog heart is had cardiotonic, Canis familiaris L. there are blood pressure lowering, diuresis, antiplatelet effects.Experimental thrombosis is formed with preventive and therapeutic effect.
The Radix Astragali: sweet, tepor.Go into spleen, lung meridian.Invigorating the spleen and replenishing QI, consolidating superficial resistance, diuretic, pus expelling by strengthening vital QI poison, granulation promoting.
Modern study contains astragalin, and coumarin etc. on one's body all can diuresis people and animal, enhancing body resistance, free radical resisting damage and lipoid peroxidization resistant.Animal capable is brought high blood pressure down blood vessel dilating.Toxicity is very low.
Radix Achyranthis Bidentatae: bitter, acid, flat.Go into liver, kidney channel.Invigorate blood circulation, clots absorbing, detumescence.
Modern study contains triterpenoid saponin, sitosterol etc., and Canis familiaris L., rabbit are had of short duration blood pressure lowering and slight diuresis.And can suppress the contraction of heart and intestinal tube.
Borneolum Syntheticum: bitter, hot, cool.Go into the heart, lung meridian.Dissipating blood stasis, clearing away heat to alleviate pain is anticorrosion.
Compared with the prior art, advantage of the present invention is:
1. general coronary heart disease treatment uses the Chinese medicine for oral administration of blood circulation promoting and blood stasis dispelling, blood vessel dilating, cardiac function enhancing, minimizing myocardial oxygen consumption merely.
In the technical solution of the present invention prescription, not only use the Chinese medicine for oral administration of blood circulation promoting and blood stasis dispelling, also used multiple (for example, Radix Achyranthis Bidentatae, Radix Notoginseng, Radix Aconiti, Herba Asari etc.) should not (or careful usefulness) routine for oral administration be used to control wind-damp dispelling, cold expelling, local anaesthesia analgesia, analgesic medicine for external use, add fragrance, have one's ideas straightened out, contain volatile oil, the Chinese medicine that penetrating power is strong; Compatible combination, Synergistic has reached and has treated the coronary heart disease effect preferably.
2. the fine size of medicine, drug powder porphyrize to granularity reaches≤74～149 μ m.
3. medication is fewer but better, only uses totally 12 kinds.
Clinical effectiveness
Warp is in the People's Hospital, Huantai County, Shandong Zibo city, the patients with coronary heart disease of making a definite diagnosis to 15 routine treatment with western unsatisfactory curative effects, on the basis of continuing Drug therapy, give the external pulvis of technical solution of the present invention simultaneously (during clinical verification, former name " heart is rather precious ") on probation, remarkable result appears in 13 examples after application as a result, average effective time 5 to 10 days, not obvious 2 examples of doing well,improving, effective percentage 86.6%; Electrocardiogram improvement rate 66.6%; Untoward reaction does not all appear.
Patient's subjective symptoms is uncomfortable in chest, dull pain is obviously improved or disappeared before the heart, and sleep improves, electrocardiogram obviously or make moderate progress, blood viscosity obviously or to some extent descended during hemorheology was checked.
The specific embodiment
The present invention is further elaborated below in conjunction with embodiment:
Embodiment 1
Weight is formed:
Radix Aconiti 2g, Herba Asari 10g, Fructus Piperis Longi 10g, Ramulus Cinnamomi 20g, Flos Caryophylli 10g, Rhizoma Chuanxiong 30g, Flos Carthami 15g, Rhizoma Corydalis 20g Radix Notoginseng 5g, Radix Astragali 45g, Radix Achyranthis Bidentatae 15g and Borneolum Syntheticum 6g.
Concoct: take by weighing above-mentioned all medicines by dosage, put≤50 ℃ of baking ovens in dry 4h, dry in the air and to room temperature, go into grinding machine for grinding, 98% by 200 mesh sieves, sieve back fine powder is packed in the Kanakin bag.
The application of above-mentioned Pharmaceutical composition in the external pulvis of preparation prevention and treatment coronary heart disease.
Make the volatile medicine bag, be fixed on left front chest (pareordia), changed once in seven to ten.
External pulvis of the present invention can fragrance activates yang, benefiting qi and removing blood stasis, dispersing cold for relieving pain; Angina pectoris, myocardial infarction and other thoracic obstruction diseases there are prevention and therapeutic effect.
Embodiment 2
Weight is formed:
Radix Aconiti 4g, Herba Asari 5g, Fructus Piperis Longi 15g, Ramulus Cinnamomi 15g, Flos Caryophylli 15g, Rhizoma Chuanxiong 20g, Flos Carthami 20g, Rhizoma Corydalis 15g, Radix Notoginseng 10g, Radix Astragali 30g, Radix Achyranthis Bidentatae 20g and Borneolum Syntheticum 3g.All the other are with embodiment 1.
Embodiment 3
Weight is formed
Radix Aconiti 3g, Herba Asari 7g, Fructus Piperis Longi 13g, Ramulus Cinnamomi 17g, Flos Caryophylli 12g, Rhizoma Chuanxiong 22g, Flos Carthami 17g, Rhizoma Corydalis 20g, Radix Notoginseng 9g, Radix Astragali 40g, Radix Achyranthis Bidentatae 20g and Borneolum Syntheticum 6g.All the other are with embodiment 1.
Embodiment 4
Weight is formed:
Radix Aconiti 2g, Herba Asari 8g, Fructus Piperis Longi 13g, Ramulus Cinnamomi 18g, Flos Caryophylli 13g, Rhizoma Chuanxiong 25g, Flos Carthami 18g, Rhizoma Corydalis 18g, Radix Notoginseng 8g, Radix Astragali 35g, Radix Achyranthis Bidentatae 18g and Borneolum Syntheticum 5g.All the other are with embodiment 1.
Embodiment 5
Weight is formed:
Radix Aconiti 4g, Herba Asari 6g, Fructus Piperis Longi 15g, Ramulus Cinnamomi 15g, Flos Caryophylli 15g, Rhizoma Chuanxiong 20g, Flos Carthami 20g, Rhizoma Corydalis 15g, Radix Notoginseng 10g, Radix Astragali 30g, Radix Achyranthis Bidentatae 20g and Borneolum Syntheticum 3g.All the other are with embodiment 1.
Embodiment 6
Weight is formed
Radix Aconiti 3g, Herba Asari 7g, Fructus Piperis Longi 12g, Ramulus Cinnamomi 17g, Flos Caryophylli 14g, Rhizoma Chuanxiong 28g, Flos Carthami 15g, Rhizoma Corydalis 20g, Radix Notoginseng 9g, Radix Astragali 40g, Radix Achyranthis Bidentatae 20g and Borneolum Syntheticum 6g.All the other are with embodiment 1.
Embodiment 7
Weight is formed:
Radix Aconiti 4g, Herba Asari 8g, Fructus Piperis Longi 10g, Ramulus Cinnamomi 20g, Flos Caryophylli 10g, Rhizoma Chuanxiong 30g, Flos Carthami 16g, Rhizoma Corydalis 18g, Radix Notoginseng 5g, Radix Astragali 35g, Radix Achyranthis Bidentatae 15g and Borneolum Syntheticum 3g.All the other are with embodiment 1.
Claims (6)
1. Chinese medicine composition for the treatment of coronary heart disease is characterized in that being made up of following components by part by weight:
3～6 parts of 2～4 parts of Radix Aconitis, 5～10 parts of Herba Asaris, 10～15 parts of Fructus Piperis Longi, 15～20 parts of Ramulus Cinnamomi, 10～15 parts of Flos Caryophyllis, 20～30 parts of Rhizoma Chuanxiongs, 15～20 parts on Flos Carthami, 15～20 parts of Rhizoma Corydalis, 5～10 parts of Radix Notoginseng, 30～45 parts of the Radixs Astragali, 15～20 parts of Radix Achyranthis Bidentataes and Borneolum Syntheticums.
2. according to the Chinese medicine composition of the described treatment coronary heart disease of claim 1, it is characterized in that forming: 3～4 parts of 2～3 parts of Radix Aconitis, 8～10 parts of Herba Asaris, 10～12 parts of Fructus Piperis Longi, 18～20 parts of Ramulus Cinnamomi, 10～12 parts of Flos Caryophyllis, 20～22 parts of Rhizoma Chuanxiongs, 18～20 parts on Flos Carthami, 18～20 parts of Rhizoma Corydalis, 5～7 parts of Radix Notoginseng, 30～35 parts of the Radixs Astragali, 18～20 parts of Radix Achyranthis Bidentataes and Borneolum Syntheticums by following components by part by weight.
3. according to the Chinese medicine composition of the described treatment coronary heart disease of claim 1, it is characterized in that forming by following components by part by weight:
3 parts of 2 parts of Radix Aconitis, 10 parts of Herba Asaris, 10 parts of Fructus Piperis Longi, 20 parts of Ramulus Cinnamomi, 10 parts of Flos Caryophyllis, 20 parts of Rhizoma Chuanxiongs, 20 parts on Flos Carthami, 20 parts of Rhizoma Corydalis, 5 parts of Radix Notoginseng, 30 parts of the Radixs Astragali, 20 parts of Radix Achyranthis Bidentataes and Borneolum Syntheticums.
4. according to the Chinese medicine composition of claim 1,2 or 3 described treatment coronary heart disease, the dosage form that it is characterized in that described Pharmaceutical composition is a powder.
5. according to the preparation method of the Chinese medicine composition of claim 1,2 or 3 described treatment coronary heart disease, it is characterized in that taking by weighing above-mentioned all medicines by dosage, insert and grind in the apparatus, porphyrize to epigranular reaches≤74～149 μ m altogether, pack in the gas-pervious textile bag, it is standby to make the volatile medicine bag.
6. according to the Chinese medicine composition of claim 1,2 or 3 described treatment coronary heart disease, it is characterized in that the application of described Chinese medicine composition in the external pulvis of preparation prevention and treatment coronary heart disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410024102 CN1259933C (en) | 2004-05-13 | 2004-05-13 | Chinese medicinal composition for treating coronary disease and its preparation and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410024102 CN1259933C (en) | 2004-05-13 | 2004-05-13 | Chinese medicinal composition for treating coronary disease and its preparation and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1569172A CN1569172A (en) | 2005-01-26 |
| CN1259933C true CN1259933C (en) | 2006-06-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410024102 Expired - Fee Related CN1259933C (en) | 2004-05-13 | 2004-05-13 | Chinese medicinal composition for treating coronary disease and its preparation and application |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869689B (en) * | 2010-06-22 | 2011-12-14 | 杨丽华 | External Chinese medicinal composition for treating angina pectoris coronary heart disease |
| CN102772590B (en) * | 2012-07-23 | 2014-03-12 | 广东省中医院 | Traditional Chinese medicine composition, gel paste and preparation method |
| CN106491958B (en) * | 2015-09-08 | 2020-04-17 | 上海中医药大学附属曙光医院 | Chinese medicinal compound preparation for treating coronary heart disease and angina pectoris and preparation method thereof |
| CN108434288A (en) * | 2018-06-18 | 2018-08-24 | 马南行 | A kind of composition for heart disease prevention and treatment |
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