CN1252475C - 凝集反应以及分离容器 - Google Patents
凝集反应以及分离容器 Download PDFInfo
- Publication number
- CN1252475C CN1252475C CNB03140653XA CN03140653A CN1252475C CN 1252475 C CN1252475 C CN 1252475C CN B03140653X A CNB03140653X A CN B03140653XA CN 03140653 A CN03140653 A CN 03140653A CN 1252475 C CN1252475 C CN 1252475C
- Authority
- CN
- China
- Prior art keywords
- chamber
- lining
- box
- plug
- post
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 title claims description 68
- 230000004520 agglutination Effects 0.000 title abstract description 3
- 230000004888 barrier function Effects 0.000 claims abstract description 36
- 239000011159 matrix material Substances 0.000 claims abstract description 11
- 239000012530 fluid Substances 0.000 claims description 21
- 230000005484 gravity Effects 0.000 claims description 14
- 229920002379 silicone rubber Polymers 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 55
- 238000011534 incubation Methods 0.000 abstract description 25
- 239000000376 reactant Substances 0.000 abstract description 12
- 238000007818 agglutination assay Methods 0.000 abstract description 2
- 210000000601 blood cell Anatomy 0.000 abstract description 2
- 210000003743 erythrocyte Anatomy 0.000 description 38
- 239000002609 medium Substances 0.000 description 28
- 238000002955 isolation Methods 0.000 description 27
- 239000000427 antigen Substances 0.000 description 18
- 102000036639 antigens Human genes 0.000 description 18
- 108091007433 antigens Proteins 0.000 description 18
- 239000007788 liquid Substances 0.000 description 17
- 230000004523 agglutinating effect Effects 0.000 description 16
- 238000000926 separation method Methods 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- 239000000463 material Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 12
- 230000000717 retained effect Effects 0.000 description 12
- 210000002966 serum Anatomy 0.000 description 11
- 238000012546 transfer Methods 0.000 description 11
- 239000002184 metal Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 239000012749 thinning agent Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 239000011521 glass Substances 0.000 description 7
- 239000004033 plastic Substances 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 239000004743 Polypropylene Substances 0.000 description 6
- -1 polypropylene Polymers 0.000 description 6
- 229920001155 polypropylene Polymers 0.000 description 6
- 230000032258 transport Effects 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 6
- 239000011888 foil Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 239000006172 buffering agent Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000002788 crimping Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- 229920004943 Delrin® Polymers 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000012966 insertion method Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- KPTYXJLOWLVCMU-UHFFFAOYSA-N 67252-82-8 Chemical compound C1=CC2=CC=CC=C2C2=C1C(C1OC1C(C1O)O)=C1C=C2 KPTYXJLOWLVCMU-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000009527 percussion Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US595719 | 1996-02-02 | ||
US08/595,719 US5780248A (en) | 1993-07-15 | 1996-02-02 | Foil sealed cassette for agglutination reactions and liner therefor |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB971109168A Division CN1145532C (zh) | 1996-02-02 | 1997-02-02 | 用于凝集反应的金属箔密封盒及用于该盒的衬套 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1487298A CN1487298A (zh) | 2004-04-07 |
CN1252475C true CN1252475C (zh) | 2006-04-19 |
Family
ID=24384398
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB03140653XA Expired - Lifetime CN1252475C (zh) | 1996-02-02 | 1997-02-02 | 凝集反应以及分离容器 |
CNB971109168A Expired - Lifetime CN1145532C (zh) | 1996-02-02 | 1997-02-02 | 用于凝集反应的金属箔密封盒及用于该盒的衬套 |
CNA2006101016873A Pending CN1908670A (zh) | 1996-02-02 | 1997-02-02 | 凝集反应以及分离容器 |
CNB2004100068725A Expired - Lifetime CN100396378C (zh) | 1996-02-02 | 1997-02-02 | 用于进行凝集测定的容器 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB971109168A Expired - Lifetime CN1145532C (zh) | 1996-02-02 | 1997-02-02 | 用于凝集反应的金属箔密封盒及用于该盒的衬套 |
CNA2006101016873A Pending CN1908670A (zh) | 1996-02-02 | 1997-02-02 | 凝集反应以及分离容器 |
CNB2004100068725A Expired - Lifetime CN100396378C (zh) | 1996-02-02 | 1997-02-02 | 用于进行凝集测定的容器 |
Country Status (14)
Country | Link |
---|---|
KR (1) | KR100503257B1 (ru) |
CN (4) | CN1252475C (ru) |
AR (1) | AR005685A1 (ru) |
BR (1) | BR9700847A (ru) |
CO (1) | CO4790148A1 (ru) |
GR (1) | GR1003213B (ru) |
HR (1) | HRP970061B1 (ru) |
IL (1) | IL120120A (ru) |
MY (2) | MY128785A (ru) |
PE (1) | PE104298A1 (ru) |
PL (1) | PL189791B1 (ru) |
RU (2) | RU2191382C2 (ru) |
SG (2) | SG78267A1 (ru) |
ZA (1) | ZA97849B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004005139A1 (de) | 2004-02-02 | 2005-08-18 | Prisma Diagnostika Gmbh | Testelement und Verfahren zum Testen von Blut |
US8058073B2 (en) * | 2008-01-30 | 2011-11-15 | Ortho-Clinical Diagnostics, Inc. | Immunodiagnostic test cards having indicating indicia |
US7850917B2 (en) * | 2008-03-11 | 2010-12-14 | Ortho-Clinical Diagnostics, Inc. | Particle agglutination in a tip |
IT1393104B1 (it) * | 2009-02-25 | 2012-04-11 | Sentinel Ch S P A | Provetta perfezionata per la raccolta, il trasporto e l'estrazione di campioni di feci |
CN102608336B (zh) * | 2011-01-19 | 2014-12-24 | 刘大基 | 一次性输血交叉配血实验组合器 |
BR112014011515A2 (pt) * | 2011-11-16 | 2019-01-02 | Epistem Ltd | montagem compreendendo um recipiente de reação e uma matriz de amostra, a matriz de amostra compreendendo uma camada adsorvente superior e uma camda de fluxo lateral inferior |
CN106438668A (zh) * | 2016-08-30 | 2017-02-22 | 诺泰科生物科技(苏州)有限公司 | 一种连接组件、支架、血栓弹力仪及使用方法 |
EP3502689B1 (en) | 2017-12-19 | 2022-08-17 | Bio-Rad Europe GmbH | Method and apparatus for testing a biological sample |
NL2020385B1 (en) * | 2018-02-06 | 2019-08-14 | Labonovum B V | Device for extraction of blood serum constituents |
CN109799338B (zh) * | 2019-01-14 | 2022-02-11 | 湖南达道生物工程有限公司 | 一种适用于末梢血免疫层析定量检测的试纸及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4111754A (en) * | 1976-11-29 | 1978-09-05 | Hydow Park | Immunological testing devices and methods |
JPS56107160A (en) * | 1980-01-31 | 1981-08-25 | Takazono Sangyo Kk | Serum separation method and its device |
US5338689A (en) * | 1987-08-24 | 1994-08-16 | Stiftung Fur Diagnostische Forschung | Method and card for detecting antigens and/or antibodies |
GR1002306B (el) * | 1990-11-09 | 1996-05-08 | Ortho Diagnostic Systems Inc. | Αναλυση και διαταξη συγκολλησεως στηλης. |
US5279606A (en) * | 1991-08-28 | 1994-01-18 | Habley Medical Technology Corporation | Non-reactive composite sealing barrier |
US5282981A (en) * | 1992-05-01 | 1994-02-01 | E. I. Du Pont De Nemours And Company | Flow restrictor-separation device |
US5491067A (en) * | 1993-07-15 | 1996-02-13 | Ortho Diagnostic Systems Inc. | Agglutination reaction and separation vessel |
FR2719122B1 (fr) * | 1994-04-22 | 1996-07-12 | Scibiex Sarl | Dispositif et procédé d'analyse immunologique. |
-
1997
- 1997-01-31 HR HR08/595,719A patent/HRP970061B1/xx not_active IP Right Cessation
- 1997-01-31 AR ARP970100417A patent/AR005685A1/es active IP Right Grant
- 1997-01-31 IL IL12012097A patent/IL120120A/en not_active IP Right Cessation
- 1997-01-31 GR GR970100033A patent/GR1003213B/el not_active IP Right Cessation
- 1997-01-31 ZA ZA97849A patent/ZA97849B/xx unknown
- 1997-02-02 CN CNB03140653XA patent/CN1252475C/zh not_active Expired - Lifetime
- 1997-02-02 CN CNB971109168A patent/CN1145532C/zh not_active Expired - Lifetime
- 1997-02-02 CN CNA2006101016873A patent/CN1908670A/zh active Pending
- 1997-02-02 CN CNB2004100068725A patent/CN100396378C/zh not_active Expired - Lifetime
- 1997-02-03 BR BR9700847A patent/BR9700847A/pt not_active IP Right Cessation
- 1997-02-03 PE PE1997000065A patent/PE104298A1/es not_active IP Right Cessation
- 1997-02-03 SG SG1997000239A patent/SG78267A1/en unknown
- 1997-02-03 SG SG200006371A patent/SG96584A1/en unknown
- 1997-02-03 MY MYPI20023256A patent/MY128785A/en unknown
- 1997-02-03 CO CO97005076A patent/CO4790148A1/es unknown
- 1997-02-03 KR KR1019970003306A patent/KR100503257B1/ko not_active IP Right Cessation
- 1997-02-03 PL PL97318258A patent/PL189791B1/pl unknown
- 1997-02-03 MY MYPI97000409A patent/MY115233A/en unknown
- 1997-03-13 RU RU97103755/14A patent/RU2191382C2/ru active
-
2001
- 2001-10-26 RU RU2001128876/14A patent/RU2276358C2/ru active
Also Published As
Publication number | Publication date |
---|---|
CN1145532C (zh) | 2004-04-14 |
CN1908670A (zh) | 2007-02-07 |
CN1198531A (zh) | 1998-11-11 |
CO4790148A1 (es) | 1999-05-31 |
CN1544948A (zh) | 2004-11-10 |
SG96584A1 (en) | 2003-06-16 |
HRP970061A2 (en) | 1998-04-30 |
HRP970061B1 (en) | 1999-12-31 |
MY128785A (en) | 2007-02-28 |
PE104298A1 (es) | 1999-01-16 |
RU2191382C2 (ru) | 2002-10-20 |
PL318258A1 (en) | 1997-08-04 |
SG78267A1 (en) | 2001-02-20 |
KR100503257B1 (ko) | 2005-11-11 |
RU2276358C2 (ru) | 2006-05-10 |
CN1487298A (zh) | 2004-04-07 |
MY115233A (en) | 2003-04-30 |
PL189791B1 (pl) | 2005-09-30 |
GR1003213B (el) | 1999-09-22 |
IL120120A0 (en) | 1997-04-15 |
AR005685A1 (es) | 1999-07-14 |
IL120120A (en) | 2001-10-31 |
CN100396378C (zh) | 2008-06-25 |
ZA97849B (en) | 1998-07-31 |
BR9700847A (pt) | 1998-09-01 |
GR970100033A (el) | 1997-10-31 |
KR970062693A (ko) | 1997-09-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2854058B2 (ja) | アッセイを実施するための方法及び装置 | |
JP5504690B2 (ja) | 分析チップ | |
US10620095B2 (en) | Apparatus and methods for detecting analytes | |
CN1009492B (zh) | 横向流动的鉴定设备 | |
AU700743B2 (en) | Cell separation apparatus and method | |
CN1252475C (zh) | 凝集反应以及分离容器 | |
US8501000B2 (en) | Methods and device employing centrifugal force | |
CN1688882A (zh) | 在线测试装置及使用方法 | |
EP0634216A2 (en) | Agglutination reaction and separation vessel | |
CN1882835A (zh) | 带有可密封的贮液池的液体样品分析装置 | |
US5780248A (en) | Foil sealed cassette for agglutination reactions and liner therefor | |
CN106076445A (zh) | 微流控试剂卡及其检测方法和应用 | |
CN111148572B (zh) | 跨界面磁性分离 | |
CN107036848A (zh) | 一种样本收集及检测的装置 | |
CN110646609A (zh) | 一种多标志物检测的磁微粒发光微流控芯片以及检测装置 | |
CN111733066A (zh) | 用于样本处理及检测的一体化试剂杯及检测样本的方法 | |
EP1582869A2 (en) | Interrupted flow testing device and method for immunological confirmatory tests | |
WO2021027082A1 (zh) | 一种样本收集及检测装置和方法 | |
EP4092412A1 (en) | Blood collection structure, and whole blood and fingerstick blood detection device and method | |
JP5125680B2 (ja) | 分離チップおよび分離方法 | |
CN2864667Y (zh) | 用于液体样本的检测装置 | |
CN210796462U (zh) | 用于样本处理及检测的一体化试剂杯 | |
CN206847996U (zh) | 样本收集及检测的装置 | |
CN109580973A (zh) | 检测试剂盒及生化免疫检测方法 | |
US20220250053A1 (en) | Apparatus and method for collecting and testing sample |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20060419 |