CN1247528A - 环戊烯酮衍生物 - Google Patents
环戊烯酮衍生物 Download PDFInfo
- Publication number
- CN1247528A CN1247528A CN98802459A CN98802459A CN1247528A CN 1247528 A CN1247528 A CN 1247528A CN 98802459 A CN98802459 A CN 98802459A CN 98802459 A CN98802459 A CN 98802459A CN 1247528 A CN1247528 A CN 1247528A
- Authority
- CN
- China
- Prior art keywords
- cyclopentenone
- acid
- derivatives
- optically active
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- BZKFMUIJRXWWQK-UHFFFAOYSA-N Cyclopentenone Chemical class O=C1CCC=C1 BZKFMUIJRXWWQK-UHFFFAOYSA-N 0.000 title claims abstract description 149
- 238000000034 method Methods 0.000 claims abstract description 31
- 230000006907 apoptotic process Effects 0.000 claims abstract description 25
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 11
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
- 125000003118 aryl group Chemical group 0.000 claims abstract description 11
- 239000000411 inducer Substances 0.000 claims abstract description 10
- 239000013543 active substance Substances 0.000 claims description 45
- 239000003814 drug Substances 0.000 claims description 37
- 150000003839 salts Chemical class 0.000 claims description 28
- 238000006243 chemical reaction Methods 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 20
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- 238000002360 preparation method Methods 0.000 abstract description 18
- 230000003287 optical effect Effects 0.000 abstract description 13
- 239000003795 chemical substances by application Substances 0.000 abstract description 10
- HLOLRONOOCGTRG-UHFFFAOYSA-N 4,5-dihydroxycyclopent-2-en-1-one Chemical compound OC1C=CC(=O)C1O HLOLRONOOCGTRG-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
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- NIONDZDPPYHYKY-SNAWJCMRSA-N (2E)-hexenoic acid Chemical compound CCC\C=C\C(O)=O NIONDZDPPYHYKY-SNAWJCMRSA-N 0.000 description 3
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- SBUXRMKDJWEXRL-ZWKOTPCHSA-N trans-body Chemical compound O=C([C@@H]1N(C2=O)[C@H](C3=C(C4=CC=CC=C4N3)C1)CC)N2C1=CC=C(F)C=C1 SBUXRMKDJWEXRL-ZWKOTPCHSA-N 0.000 description 1
- XXHDAWYDNSXJQM-ONEGZZNKSA-N trans-hex-3-enoic acid Chemical compound CC\C=C\CC(O)=O XXHDAWYDNSXJQM-ONEGZZNKSA-N 0.000 description 1
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 description 1
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- RQIDQEBURXNDKG-MDZDMXLPSA-N ximenic acid Chemical compound CCCCCCCC\C=C\CCCCCCCCCCCCCCCC(O)=O RQIDQEBURXNDKG-MDZDMXLPSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
物质名称 | 细胞增殖抑制浓度(μM) |
二乙酰基环戊烯酮二乙酰基(-)-环戊烯酮二乙酰基(+)-环戊烯酮二苯甲酰基环戊烯酮二苯甲酰基(-)-环戊烯酮二苯甲酰基(+)-环戊烯酮二己酰基环戊烯酮二肉豆蔻劳酰基环戊烯酮二辛酰基环戊烯酮二-3-辛烯酰基环戊烯酮二丁酰基环戊烯酮二癸酰基环戊烯酮二戊酰基环戊烯酮二丙酰基环戊烯酮二-2-己烯酰基环戊烯酮 | 3.93.93.97.77.77.73.01879.85.03.417.26.23.86.2 |
增殖抑制浓度 | 杀菌浓度 | |
被检验菌①被检验菌②被检验菌③ | 100100200 | 100100200 |
Claims (10)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP72855/1997 | 1997-03-11 | ||
JP72855/97 | 1997-03-11 | ||
JP7285597 | 1997-03-11 | ||
JP90011/97 | 1997-03-26 | ||
JP90011/1997 | 1997-03-26 | ||
JP9001197 | 1997-03-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1247528A true CN1247528A (zh) | 2000-03-15 |
CN1156432C CN1156432C (zh) | 2004-07-07 |
Family
ID=26413994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB988024594A Expired - Fee Related CN1156432C (zh) | 1997-03-11 | 1998-02-26 | 环戊烯酮衍生物 |
Country Status (13)
Country | Link |
---|---|
US (1) | US6136854A (zh) |
EP (1) | EP0976717B1 (zh) |
JP (1) | JP3763585B2 (zh) |
KR (1) | KR100555843B1 (zh) |
CN (1) | CN1156432C (zh) |
AT (1) | ATE228110T1 (zh) |
AU (1) | AU730766B2 (zh) |
CA (1) | CA2283634A1 (zh) |
DE (1) | DE69809544T2 (zh) |
EA (1) | EA001808B1 (zh) |
ES (1) | ES2183328T3 (zh) |
TW (1) | TW438768B (zh) |
WO (1) | WO1998040346A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106518643A (zh) * | 2016-10-14 | 2017-03-22 | 宁波大学 | 一种环戊烯酮类化合物及其制备方法和用途 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050020687A1 (en) * | 1996-01-14 | 2005-01-27 | Consiglio Nazionale Ricerche | Methods of treating inflammatory and viral disorders by administering cyclopentenone compounds |
WO1999029647A1 (fr) * | 1997-12-11 | 1999-06-17 | Takara Shuzo Co., Ltd. | Inducteurs de l'apoptose |
EP1112742B1 (en) * | 1998-08-18 | 2004-11-03 | Takara Bio Inc. | Remedies or preventives containing cyclopentenone compounds as the active ingredient |
US6720415B2 (en) | 1998-12-02 | 2004-04-13 | Princeton University | Compositions and methods for regulating bacterial pathogenesis |
US7326542B2 (en) | 1998-12-02 | 2008-02-05 | Princeton University | Compositions and methods for regulating bacterial pathogenesis |
KR20010102134A (ko) * | 1999-02-19 | 2001-11-15 | 오미야 히사시 | 치료제 |
AU3665700A (en) * | 1999-03-22 | 2000-10-09 | Charterhouse Therapeutics Ltd. | Chemical compounds and their uses |
AU3837300A (en) * | 1999-04-15 | 2000-11-02 | Takara Shuzo Co., Ltd. | Remedies |
GB9929702D0 (en) * | 1999-12-16 | 2000-02-09 | Charterhouse Therapeutics Ltd | Chemical compounds and their uses |
JP2003532698A (ja) | 2000-05-10 | 2003-11-05 | プリンストン ユニバーシティ | 細菌の増殖および病理発生を調節するための化合物ならびに方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0768163B2 (ja) * | 1989-03-17 | 1995-07-26 | 財団法人野口研究所 | シクロペンテノン誘導体の製法 |
-
1998
- 1998-02-26 EP EP98905690A patent/EP0976717B1/en not_active Expired - Lifetime
- 1998-02-26 CA CA002283634A patent/CA2283634A1/en not_active Abandoned
- 1998-02-26 AU AU61177/98A patent/AU730766B2/en not_active Ceased
- 1998-02-26 AT AT98905690T patent/ATE228110T1/de not_active IP Right Cessation
- 1998-02-26 JP JP53941998A patent/JP3763585B2/ja not_active Expired - Fee Related
- 1998-02-26 CN CNB988024594A patent/CN1156432C/zh not_active Expired - Fee Related
- 1998-02-26 KR KR1019997006316A patent/KR100555843B1/ko not_active IP Right Cessation
- 1998-02-26 EA EA199900812A patent/EA001808B1/ru not_active IP Right Cessation
- 1998-02-26 ES ES98905690T patent/ES2183328T3/es not_active Expired - Lifetime
- 1998-02-26 WO PCT/JP1998/000817 patent/WO1998040346A1/ja active IP Right Grant
- 1998-02-26 DE DE69809544T patent/DE69809544T2/de not_active Expired - Fee Related
- 1998-03-03 TW TW087103046A patent/TW438768B/zh not_active IP Right Cessation
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1999
- 1999-07-21 US US09/359,069 patent/US6136854A/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106518643A (zh) * | 2016-10-14 | 2017-03-22 | 宁波大学 | 一种环戊烯酮类化合物及其制备方法和用途 |
CN106518643B (zh) * | 2016-10-14 | 2019-02-15 | 宁波大学 | 一种环戊烯酮类化合物及其制备方法和用途 |
Also Published As
Publication number | Publication date |
---|---|
EA001808B1 (ru) | 2001-08-27 |
EP0976717A4 (en) | 2000-05-17 |
JP3763585B2 (ja) | 2006-04-05 |
EA199900812A1 (ru) | 2000-04-24 |
EP0976717B1 (en) | 2002-11-20 |
DE69809544T2 (de) | 2003-10-02 |
CN1156432C (zh) | 2004-07-07 |
ATE228110T1 (de) | 2002-12-15 |
AU730766B2 (en) | 2001-03-15 |
CA2283634A1 (en) | 1998-09-17 |
EP0976717A1 (en) | 2000-02-02 |
TW438768B (en) | 2001-06-07 |
AU6117798A (en) | 1998-09-29 |
KR100555843B1 (ko) | 2006-03-03 |
US6136854A (en) | 2000-10-24 |
ES2183328T3 (es) | 2003-03-16 |
WO1998040346A1 (fr) | 1998-09-17 |
KR20000062429A (ko) | 2000-10-25 |
DE69809544D1 (de) | 2003-01-02 |
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