CN1241573A - 无内源性免疫球蛋白的肝癌鼠源单抗、制备方法及其应用 - Google Patents
无内源性免疫球蛋白的肝癌鼠源单抗、制备方法及其应用 Download PDFInfo
- Publication number
- CN1241573A CN1241573A CN 99113824 CN99113824A CN1241573A CN 1241573 A CN1241573 A CN 1241573A CN 99113824 CN99113824 CN 99113824 CN 99113824 A CN99113824 A CN 99113824A CN 1241573 A CN1241573 A CN 1241573A
- Authority
- CN
- China
- Prior art keywords
- litre
- monoclonal antibody
- liver cancer
- acid
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
注射后天数 | 组别(n=12/组) |
低剂量组 中剂量组 高剂量组 游离131I组 对照组(50μCi) (100μCi) (500μCi) | |
0 + + + + +1 + + - + +3 + + + 1.21±1.11 1.32±1.046 2.64±1.34 + + 2.83±1.72 3.44±0.969 244.09±122.33 43.62±11.66 52.38±12.34 388.62±174.44 540.66±133.2112 432.52±169.38 378.46±189.37 339.41±178.43 488.96±212.38 612.97±167.4415 588.96±178.77 407.35±236.43 378.52±169.33 604.08±244.34 688.24±233.2318 645.25±212.32 578 64±268.72 471.34±172.32 1222.46±484.34 1388.78±344.7821 832.41±386.62 734.56±242.38 686.72±312.17 1296.20±323.32 1496.93±588.3224 878.94±277.17 793.45±343.51 741.33±327.24 1424.66±515.24 1588.92±464.6627 1033.34±534.33 823.86±443.63 787.45±388.34 1893.32±777.82 1998.94±932.2330 1427.32±767.74 1231.48±817.48 1123.48±787.63 2448.46±1233.42 2643.55±1323.34 |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 99113824 CN1114619C (zh) | 1999-06-25 | 1999-06-25 | 小鼠杂交瘤株Hepama-1分泌的肝癌鼠源单克隆抗体的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 99113824 CN1114619C (zh) | 1999-06-25 | 1999-06-25 | 小鼠杂交瘤株Hepama-1分泌的肝癌鼠源单克隆抗体的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1241573A true CN1241573A (zh) | 2000-01-19 |
CN1114619C CN1114619C (zh) | 2003-07-16 |
Family
ID=5276972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 99113824 Expired - Fee Related CN1114619C (zh) | 1999-06-25 | 1999-06-25 | 小鼠杂交瘤株Hepama-1分泌的肝癌鼠源单克隆抗体的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1114619C (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105143444A (zh) * | 2013-03-15 | 2015-12-09 | 瑞泽恩制药公司 | 无血清细胞培养基 |
CN105473614A (zh) * | 2013-08-20 | 2016-04-06 | 斯洛文尼亚莱柯制药股份有限公司 | 用于控制多肽的α-酰胺化和/或C-末端氨基酸分裂的细胞培养基和方法 |
CN108623676A (zh) * | 2018-03-20 | 2018-10-09 | 重庆中元汇吉生物技术有限公司 | 一种提高单克隆抗体产量的方法及其应用 |
CN109892320A (zh) * | 2019-03-20 | 2019-06-18 | 浙江省人民医院 | 一种细胞保存液及其制备方法和应用 |
US10927342B2 (en) | 2015-08-04 | 2021-02-23 | Regeneran Pharmaceuticals, Inc. | Taurine supplemented cell culture medium and methods of use |
CN112881578A (zh) * | 2019-11-29 | 2021-06-01 | 中国科学院大连化学物理研究所 | 一种用于肝癌预后风险评估的试剂盒及应用 |
WO2021113938A1 (pt) * | 2019-12-09 | 2021-06-17 | Cellavit Representação De Produtos Naturais Ltda | Suplemento alimentar vitamínico-mineral |
-
1999
- 1999-06-25 CN CN 99113824 patent/CN1114619C/zh not_active Expired - Fee Related
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105143444A (zh) * | 2013-03-15 | 2015-12-09 | 瑞泽恩制药公司 | 无血清细胞培养基 |
US11970724B2 (en) | 2013-03-15 | 2024-04-30 | Regeneron Pharmaceuticals, Inc. | Serum-free cell culture medium |
US11332771B2 (en) | 2013-03-15 | 2022-05-17 | Regeneron Pharmaceuticals, Inc. | Serum-free cell culture medium |
CN105473614A (zh) * | 2013-08-20 | 2016-04-06 | 斯洛文尼亚莱柯制药股份有限公司 | 用于控制多肽的α-酰胺化和/或C-末端氨基酸分裂的细胞培养基和方法 |
EP3036254A1 (en) * | 2013-08-20 | 2016-06-29 | LEK Pharmaceuticals d.d. | Cell culture medium and process for controlling -amidation and/or c-terminal amino acid cleavage of polypeptides |
CN105473614B (zh) * | 2013-08-20 | 2019-11-01 | 斯洛文尼亚莱柯制药股份有限公司 | 用于控制多肽的α-酰胺化和/或C-末端氨基酸分裂的细胞培养基和方法 |
US11312936B2 (en) | 2015-08-04 | 2022-04-26 | Regeneron Pharmaceuticals, Inc. | Taurine supplemented cell culture medium and methods of use |
US10927342B2 (en) | 2015-08-04 | 2021-02-23 | Regeneran Pharmaceuticals, Inc. | Taurine supplemented cell culture medium and methods of use |
CN108623676A (zh) * | 2018-03-20 | 2018-10-09 | 重庆中元汇吉生物技术有限公司 | 一种提高单克隆抗体产量的方法及其应用 |
CN108623676B (zh) * | 2018-03-20 | 2021-07-30 | 重庆中元汇吉生物技术有限公司 | 一种提高单克隆抗体产量的方法及其应用 |
CN109892320A (zh) * | 2019-03-20 | 2019-06-18 | 浙江省人民医院 | 一种细胞保存液及其制备方法和应用 |
CN112881578A (zh) * | 2019-11-29 | 2021-06-01 | 中国科学院大连化学物理研究所 | 一种用于肝癌预后风险评估的试剂盒及应用 |
WO2021113938A1 (pt) * | 2019-12-09 | 2021-06-17 | Cellavit Representação De Produtos Naturais Ltda | Suplemento alimentar vitamínico-mineral |
Also Published As
Publication number | Publication date |
---|---|
CN1114619C (zh) | 2003-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Montico et al. | Immunogenic apoptosis as a novel tool for anticancer vaccine development | |
Binatti et al. | The role of macrophages in liver fibrosis: new therapeutic opportunities | |
Caiola et al. | Glutaminase inhibition on NSCLC depends on extracellular alanine exploitation | |
CN1241573A (zh) | 无内源性免疫球蛋白的肝癌鼠源单抗、制备方法及其应用 | |
CN102517213B (zh) | 用于t淋巴细胞的体外培养试剂盒 | |
CN113876946B (zh) | 一种pd-1抗体和绿脓杆菌的联合制药用途及药物组合物 | |
US3039932A (en) | Tissue culturing with arginine, citrulline or aspartic acids supplements to the media | |
CN114507640B (zh) | 一种高增殖能力和高细胞毒性cik细胞的培养方法及其应用 | |
Cheng et al. | Preconditioned mesenchymal stromal cells to improve allotransplantation outcome | |
Grijalva Garces et al. | A Novel Approach for the Manufacturing of Gelatin-Methacryloyl | |
CN107406832A (zh) | 具有受控铜离子的制备方法 | |
CN1180080C (zh) | 一种改进的肝癌鼠源单克隆抗体的制备方法 | |
CN1703506A (zh) | 在均相体系中大规模培养t-淋巴细胞的方法 | |
Blagov et al. | Effects of metabolic disorders in immune cells and synoviocytes on the development of rheumatoid arthritis | |
Xu et al. | Exosomes derived from yak follicular fluid increase 2-hydroxyestradiol secretion by activating autophagy in cumulus cells | |
CN109294970B (zh) | 阿胶在制备促细胞分裂繁殖、抗凋亡的细胞培养物中的应用 | |
CN87104270A (zh) | 改进的融合方法 | |
CN107988154B (zh) | 一种组合物及其制备方法与应用 | |
Chen et al. | Lactation activity and mechanism of milk-protein synthesis by peptides from oyster hydrolysates | |
Deng et al. | Development of Glycosylation-Modified DPPA-1 Compounds as Innovative PD-1/PD-L1 Blockers: Design, Synthesis, and Biological Evaluation | |
Ozturk | Kinetic characterization of hybridoma growth, metabolism, and monoclonal antibody production rates | |
CN117187181B (zh) | 包被组合物的方法及其应用 | |
CN1137139C (zh) | 重组淋巴毒素衍生物的生产工艺 | |
US20240083972A1 (en) | Cell culture method | |
Condorelli et al. | Retrospective Monocentric Clinical Study on Male Infertility: Comparison between Two Different Therapeutic Schemes Using Follicle-Stimulating Hormone |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: SHANGHAI INST. OF LIFE SCIENCE, CAS Free format text: FORMER NAME OR ADDRESS: SHANGHAI INST. OF CYTOBIOLOGY, CHINESE ACADEMY OF SCIENCES |
|
CP01 | Change in the name or title of a patent holder |
Address after: 200031 No. 320, Yueyang Road, Shanghai Co-patentee after: Shanghai Meishan Biological Technology Co., Ltd. Patentee after: Shanghai Institute of life Sciences, Chinese Academy of Sciences Address before: 200031 No. 320, Yueyang Road, Shanghai Co-patentee before: Shanghai Meishan Biological Technology Co., Ltd. Patentee before: Shanghai Inst. of Cell Biology, Chinese Academy of Sciences |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1054334 Country of ref document: HK |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20030716 Termination date: 20160625 |
|
CF01 | Termination of patent right due to non-payment of annual fee |