CN1241409A - Lotion for tinea pedis - Google Patents

Lotion for tinea pedis Download PDF

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Publication number
CN1241409A
CN1241409A CN 98102843 CN98102843A CN1241409A CN 1241409 A CN1241409 A CN 1241409A CN 98102843 CN98102843 CN 98102843 CN 98102843 A CN98102843 A CN 98102843A CN 1241409 A CN1241409 A CN 1241409A
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tinea
pedis
foot
lotion
evil
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CN 98102843
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Chinese (zh)
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王秉岳
马文香
杨平
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王秉岳
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Abstract

The lotion as one Chinese medicine preparation for preventing and treating tinea pedis scan remove foot smell, eliminate foot sweat, stop itching and cure tinea pedis. When it is used to soak foot, it has obvious effects of clearing away heat evil, drying the wetness evil, detoxicating, stopping itching, deodoring and soothing sinew without irritation to skin, harmful effect and toxic side effect.

Description

一种脚癣洗液 One kind of athlete's foot lotion

本发明涉及一种预防和治疗脚癣的中药制剂,特别是一种具有祛脚臭、除脚汗、止痒、祛脚癣的脚癣洗液。 The present invention relates to a traditional Chinese medicine preparation for preventing and treating athlete's foot, in particular having a cured odor, in addition to sweat, itching, athlete's foot lotion cured athlete's foot.

随着社会文明化进程,对脚癣、脚臭、脚汗的预防和治疗得到社会的重视,人们在不断研究各种不同的治疗方法及相应的各种药品,如采用核桃青皮捣烂滤汁、涂抹,桑皮汁涂抹,儿茶齿苋汤浸泡,以及上市出售的中西外用成药,如酊剂、癣湿药水、香港脚气水、软膏剂、水扬酸软膏、达克宁霜等,上述药品虽然对脚癣这一顽症有一定的治疗效果,但核桃青皮等使用麻烦,取料困难难以形成规模化生产。 With the process of social civilization, for athlete's foot, foot odor, sweat prevention and treatment of social attention, people continue to study a variety of treatment methods and the corresponding variety of drugs, such as the use Walnut smashed filter juice, painting, painting mulberry juice, soup soaking catechu Portulaca oleracea, Chinese and Western medicine topical listed for sale, such as tincture, syrup wet ringworm, athlete's foot water Hong Kong, ointments, salicylic acid ointment, cream, Miconazole, although these drugs for athlete's foot this chronic have a therapeutic effect, but cumbersome to use other walnut, reclaimer is difficult to form large-scale production difficult. 中西外用药如酊剂等刺激性强,在皮损面积较大、药物浓度较高时,易发生药物吸收后的毒性反映,软膏剂对于皮肤炎症大面积使用同样易发生药物的毒付作用,综上所述现使用各种脚癣治疗药物,都是在病性较重时用于治疗使用,并具有一定的毒付作用,而难以做到对脚癣、脚臭、脚汗等进行治疗和预防。 The outer and Western medicine tincture strong irritant, a larger area of ​​skin lesions, a high concentration of the drug, toxicity of the drug absorption after reflecting prone to inflammation of the skin ointments toxic effect to pay a large area prone to the same drug, mechanized now the athlete's foot treatment using various drugs are used to treat severe disease in nature, and have certain toxic side effects, it is difficult to achieve for athlete's foot, foot odor, sweat or the like treatment and prevention.

本发明的目的是发明一种中药制剂,对脚癣、脚臭和脚汗有治疗和预防的目的,而且具有使用方便、疗效显著、适用范围广、价格低廉等优点。 Object of the present invention is to invent a traditional Chinese medicine preparation for athlete's foot, foot odor and sweat purpose of treatment and prevention, easy to use and has a significant effect, wide application range, low cost advantages.

本发明中药配方由苦参6-8份,黄柏6-7份,白鲜皮5-6份,蛇床子6份,土茯苓6-8份,地肤子6份,枯矾6份,木瓜6份,藿香6-8份,川花椒2-3份,苯甲酸钠0.125份组成。 Chinese medicine formulations of the present invention is 6-8 parts flavescens, cork parts 6-7, 5-6 parts of fresh white skin, Cnidium 6 parts, parts 6-8 Smilax, Kochia scoparia parts 6, 6 parts of alum, papaya 6 parts, parts of Agastache 6-8, 2-3 parts by Sichuan pepper, 0.125 parts sodium acid composition. 上述配方主要采用中医清热燥湿、解毒止痒、除臭舒筋的治疗法则。 The main use of the above formula of traditional Chinese medicine heat dampness, detoxification itching, deodorant getting the treatment rule.

方中苦参苦寒,功能清热燥湿,治阴疮湿痒;黄柏苦寒,清热燥湿,泻火解毒,二者共为主药奏清热燥湿之功。 Fang flavescens bitter cold, functional heat dampness, yin sore wet itch; Cork bitter cold, heat and dampness, purging fire detoxification, both of which were based medicine heat dampness of the power play. 白鲜皮苦咸、寒、祛风燥湿、清热解毒,功擅治疥癣、痒疹;蛇床子辛苦、温、祛风燥湿、擅治湿疹阴痒,助主药燥湿兼具止痒之力。 Dictamni brackish, cold, dampness chills, detoxification, Gong trespassing cure scabies, prurigo; Cnidium hard, temperature, chills and dampness, good cure eczema pruritus vulvae, both co-primary drug antipruritic dampness Power. 土茯苓甘淡、平、除湿解毒、利关节,善治脚气;地肤子甘苦、寒、清热利湿,祛风止痒,专治瘙痒湿疹,辅助主药除湿解毒之功。 Smilax sweet light, flat, dehumidification detoxification, Lee joints, good governance beriberi; belvedere fruit stand, cold, heat and dampness, chills and itching, itching eczema cures, auxiliary power dehumidification main drug detoxification. 佐以枯矾酸湿、寒、燥湿止痒、收湿敛疮,以治渗液,止汗;木瓜酸温,祛湿舒筋,以今足部洗后舒适并专治干脚气。 Combined with alum acid wet, cold, dampness itching, close wet sores, to cure exudate, antiperspirant; papaya acid temperature, dampness getting to this washed the feet comfortable and dry cures athlete's foot. 藿香辛、微温、祛湿、辟秽,佐于大队寒凉药中同以椒既除湿祛臭、又增芳香之气,并可促进皮肤吸收。 Oct rugosa, tepid, dampness, the provision of filth, in Zuo brigade with cold medicine to both pepper dehumidification deodorant, fragrance and increase of the gas, and promote skin absorption. 奏清热燥湿,解毒止痒之功,又具除臭舒筋止汗之力。 Played heat dampness, detoxification itching of power, but also with getting antiperspirant deodorant force. 本发明所选药物大多具有对皮肤真菌的抑制作用,及对细菌有抑制作用,而各药物间对真菌和细菌的抗菌谱不尽一致,组方后各药作用相互交叉,互补抑菌效力,使本发明具有较广的抗菌谱,增加了抑菌效力。 Selected agents of the invention inhibit the most dermatophytes, and inhibit bacteria, among pharmaceutical antibacterial spectrum of fungi and bacteria are not the same, the effect of prescription drugs intersect each complementary antibacterial effect, of the present invention has a wide antibacterial spectrum, increased inhibitory potency. 因而,本发明对导致脚癣的真菌和多种细菌繁殖体具有较强的抑制作用。 Accordingly, the present invention has a strong inhibitory effect on various fungi and bacteria cause athlete's foot body.

本发明的制备方法是:将处方所用药材按《药典》要求质量标准鉴定后,按一般饮片要求予以粉碎或炮制。 The method of preparation of the present invention is: after the medicine according to the prescription "Pharmacopoeia" quality standard requirements for the identification, according to the general requirements to be pulverized or cooked slices. 然后将各药(除藿香、苯甲酸钠外)放入提取罐中加7倍水,先浸泡30分钟,煎煮2次,第一次煎1.5小时第二次加水5倍,煎1小时,合并药液过滤,放入浓缩罐浓缩至400-500ml。 Then each of the drugs (except rugosa, sodium benzoate) was placed in an extraction tank 7 times of water was added, to soak for 30 minutes, boiling twice, first fried 1.5 hours water was added 5 times a second, fried 1 hour, The combined liquid was filtered, concentrated to concentrating tank into 400-500ml. 藿香加3-5倍量乙醇,密闭浸渍提取5-7日,将提取液过滤,兑入冷却后的上液,并加入与上液等量的95%乙醇,搅匀,静置沉淀24小时,吸取上清液,余液滤过。 Agastache 3-5 times the amount of ethanol added, to extract the sealed impregnation 5-7, extract was filtered, the solution is blended after cooling, and the solution was added with an equal amount of 95% ethanol, mix well and left to settle for 24 hours, the supernatant, the remaining liquid was filtered. 合并上清液和滤液,减压蒸馏回收乙醇,并浓缩至250ml。 The supernatant and filtrate were combined, evaporated under reduced pressure to recover ethanol and concentrated to 250ml. 加苯甲酸钠1.25g,使苯甲酸钠浓度达到0.5%,滤过,投入消毒后,洁净干燥的药瓶包装,经高压蒸气消毒后,即得。 Sodium benzoate 1.25g, so that a concentration of 0.5% sodium benzoate, filtered, put into sterilized, clean, dry vial packaging, after autoclaving, i.e., too.

在本发明的制备工艺过程中,一般药品采用煎煮提取有效成分,而藿香根据其气味辛香,含挥发油,煎煮时易挥发损失,和其浸出液的抑菌效力大于煎液的现代药理研究,故用乙醇浸渍提取,既保持了芳香气味,又使其保持了高效的抗菌效力。 In the preparation process of the present invention, generally decocting extraction pharmaceutical active ingredients, and according to its Agastache spicy odor, volatile oil, volatile loss during boiling, and antibacterial efficacy is greater than the leaching solution Pharmacological decoction studies, it was immersed in ethanol extraction, while maintaining the aroma, but also to keep a high antimicrobial efficacy.

采用减压蒸馏,目的在于使药液在较低温度下沸腾汽化,使药物有效成份在回收乙醇和浓缩时较少损失,保证药品质量。 Using vacuum distillation, Boiling purpose is to make liquid at lower temperatures, less drug loss of active ingredient in the recovery of ethanol and concentrated to ensure the quality of medicines. 同时缩短了蒸馏时间,提高了蒸馏效率。 At the same time shorten the distillation time and improve the efficiency of the distillation.

本发明可直接涂抹患处,或加温开水配制成10%浓度,浸泡足部20分钟。 The present invention can be directly applied to the affected area, or formulated into warm water of 10% concentration, the foot soak for 20 minutes.

本发明由天然纯中药精制提炼而成,不含乙醇等对皮肤有刺激的化学物质,仅加入可内服外用的并具较好抑菌作用的防腐剂苯甲酸钠。 The present invention is extracted by a pure natural Chinese medicine refining, free of ethanol, to stimulate the skin chemicals, sodium benzoate may be added only oral topical and having better antibacterial effect. 因而本品对皮肤无刺激,无不良反应和毒副作用,安全而效验。 This product is therefore non-irritating to the skin, no adverse reactions and side effects, safety and efficacy. 因本品对足部皮肤有消毒抑菌、硬化止汁作用,故用以防治脚癣、脚臭、脚汗有显著疗效。 Because of the materials for the antibacterial foot skin disinfection, juice stop hardening effect, it is for the control of athlete's foot, foot odor, sweat significant effect. 并因具藿香的特殊芳香气味,用后使脚部皮肤干爽清洁、气味芳香、舒适宜人。 And because of special aroma of patchouli, after using the foot skin clean and dry, aromatic scent, comfortable and pleasant.

本发明经河北医科大学教学医院、河北省行唐县中医院临床试用,在对400余例脚癣或继发感者的治疗中,1-2疗程(用10%浓度每日浸泡20分钟,7日为1疗程),治愈好转率达90%以上,其中部分患者愈后经化验室作真菌及细菌培养无阳性反应。 The present invention is by Hebei Medical University Teaching Hospital, Hospital of Hebei Xingtang clinical trials in the treatment of more than 400 cases of athlete's foot or secondary sense of those, 1-2 treatment (with 10% strength day soak for 20 minutes, 7 day course of treatment) the cure rate of 90%, after which some patients prognosis of laboratory for fungal and bacterial culture, no positive reaction. 临床未见皮肤刺激、损伤、过敏等不良反应。 No clinical skin irritation, damage, allergies and other adverse reactions.

本发明经河北省卫生防疫站检验[MA(89)量认(冀)字(Q0103)号],毒理报告书称:小鼠经口急性毒性实验(ID50)结果:各组动物无中毒症状及死亡。 The present invention is by testing epidemic station Hebei [MA (89) of recognition (Ji) Zi (Q0103)], toxicological report says: Acute toxicity test in mice (the ID50) Results: All the animals no symptoms and death. 结论:按消毒技术技术规范急性毒性分级该受试物属实际无毒物;家兔急性皮肤刺激试验结果:皮肤刺激积分为0。 Conclusion: According to Technical Specification disinfection classification of acute toxicity of the test substance was practically non-toxic; acute rabbit skin irritation test results: 0 points for skin irritation. 结论:该受试物对家兔皮肤刺激强度属无刺激;小鼠骨髓细胞微核实验结论:该受试小鼠骨髓细胞微核实验阴性。 Conclusion: The rabbit skin irritation test substance is a non-intensity stimulation; Bone Marrow Cells Mouse Experimental results: The test mouse bone marrow micronucleus test-negative cells.

检验报告书结论:本发明原液作用10分钟对大肠杆菌、金黄色葡萄球菌抑菌率达90%以上,50%稀释液作用20分钟对大肠杆菌、金黄色葡萄球菌抑菌率达90%以上;本发明经加速试验,原液作用10分钟对肠杆菌抑菌率达90%以上,50%稀释液作用20分钟对大肠杆菌抑菌率达90%以上。 Inspection report concluded: effects of the present invention liquid for 10 minutes Escherichia coli, Staphylococcus aureus inhibitory rate of 90%, 50% dilution effect for 20 minutes Escherichia coli, Staphylococcus aureus inhibitory rate of 90%; The present invention is by accelerated test, the stock solution for 10 min on E. coli inhibitory rate of 90%, 50% dilution of the bacteriostatic effect for 20 minutes more than 90%.

本发明实施例,经临床试验证明,具有疗效显著、使用方便、价格低廉、无毒付作用等优点。 Embodiment of the present invention, the clinical trials, have a significant effect, the advantages of easy to use, inexpensive, non-toxic and other side effects.

Claims (1)

  1. 1.一种脚癣洗液,其特征在于所述的脚癣洗液,由下列药物组成:苦参6-8份,黄柏6-7份,白鲜皮5-6份,蛇床子6份,土茯苓6-8份,地肤子6份,枯矾6份,木瓜6份,藿香6-8份,川花椒2-3份,苯甲酸钠0.125份。 An athlete's foot lotion, wherein said athlete's foot lotion consisting of the following drugs: 6-8 parts flavescens, cork parts 6-7, 5-6 parts of fresh white skin, Cnidium 6 parts, soil Poria 6-8 parts, 6 parts Kochia scoparia, alum parts 6, 6 parts papaya, 6-8 parts of Agastache rugosa, Zanthoxyli 2-3 parts, 0.125 parts of sodium benzoate.
CN 98102843 1998-07-10 1998-07-10 Lotion for tinea pedis CN1241409A (en)

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1118284C (en) * 2000-05-31 2003-08-20 王兴远 Medicinal composition for treating beriberi and preparing process thereof
CN101036701B (en) 2006-03-17 2010-12-29 李红梅 Chinese traditional medicine lotion
CN101972270A (en) * 2010-11-09 2011-02-16 石家庄乐足科技有限公司 External powder for preventing and curing dermatophytosis
CN102228646A (en) * 2011-05-30 2011-11-02 马建国 Medicinal tincture for treating vesicle tinea pedis and preparation method thereof
CN102319324A (en) * 2011-09-01 2012-01-18 杨晓陆 Medicine for treating beriberi
CN101085069B (en) 2007-06-28 2012-03-21 乔立峰 Medicine for curing beriberi
CN102861271A (en) * 2012-10-09 2013-01-09 中国人民解放军第四军医大学 External-use inflammation-diminishing itching-relieving ointment preparation and preparation method thereof
CN102988751A (en) * 2012-10-30 2013-03-27 严中明 Traditional Chinese medicine composition for treating beriberi and preparation method thereof
CN103432480A (en) * 2013-08-17 2013-12-11 马建国 Medicinal power for treating erosion-type tinea pedis and preparation method of medicinal power
CN103550358A (en) * 2013-11-07 2014-02-05 王敬侠 Traditional Chinese medicinal composition prescription for treating dermatophytosis diseases
CN103623133A (en) * 2012-08-23 2014-03-12 李艳辉 Medicated bath formula mainly for treating beriberi
CN103933311A (en) * 2014-03-28 2014-07-23 张建民 Traditional Chinese medicine for treating barbiers
CN104274638A (en) * 2014-10-11 2015-01-14 李文霞 Preparation method of foot soaking fluid for treatment of beriberi

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1118284C (en) * 2000-05-31 2003-08-20 王兴远 Medicinal composition for treating beriberi and preparing process thereof
CN101036701B (en) 2006-03-17 2010-12-29 李红梅 Chinese traditional medicine lotion
CN101085069B (en) 2007-06-28 2012-03-21 乔立峰 Medicine for curing beriberi
CN101972270B (en) 2010-11-09 2012-07-25 石家庄乐足科技有限公司 External powder for preventing and curing dermatophytosis
CN101972270A (en) * 2010-11-09 2011-02-16 石家庄乐足科技有限公司 External powder for preventing and curing dermatophytosis
CN102228646A (en) * 2011-05-30 2011-11-02 马建国 Medicinal tincture for treating vesicle tinea pedis and preparation method thereof
CN102228646B (en) 2011-05-30 2012-10-31 马建国 Medicinal tincture for treating vesicle tinea pedis and preparation method thereof
CN102319324A (en) * 2011-09-01 2012-01-18 杨晓陆 Medicine for treating beriberi
CN102319324B (en) 2011-09-01 2013-05-08 杨晓陆 Medicine for treating beriberi
CN103623133A (en) * 2012-08-23 2014-03-12 李艳辉 Medicated bath formula mainly for treating beriberi
CN102861271A (en) * 2012-10-09 2013-01-09 中国人民解放军第四军医大学 External-use inflammation-diminishing itching-relieving ointment preparation and preparation method thereof
CN102988751A (en) * 2012-10-30 2013-03-27 严中明 Traditional Chinese medicine composition for treating beriberi and preparation method thereof
CN102988751B (en) * 2012-10-30 2015-06-24 青岛市市立医院 Traditional Chinese medicine composition for treating beriberi and preparation method thereof
CN103432480A (en) * 2013-08-17 2013-12-11 马建国 Medicinal power for treating erosion-type tinea pedis and preparation method of medicinal power
CN103550358A (en) * 2013-11-07 2014-02-05 王敬侠 Traditional Chinese medicinal composition prescription for treating dermatophytosis diseases
CN103933311A (en) * 2014-03-28 2014-07-23 张建民 Traditional Chinese medicine for treating barbiers
CN104274638A (en) * 2014-10-11 2015-01-14 李文霞 Preparation method of foot soaking fluid for treatment of beriberi

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