CN1241409A - Lotion for tinea pedis - Google Patents

Abstract

The lotion as one Chinese medicine preparation for preventing and treating tinea pedis scan remove foot smell, eliminate foot sweat, stop itching and cure tinea pedis. When it is used to soak foot, it has obvious effects of clearing away heat evil, drying the wetness evil, detoxicating, stopping itching, deodoring and soothing sinew without irritation to skin, harmful effect and toxic side effect.

Description

A kind of lotion for tinea pedis

The present invention relates to the Chinese medicine preparation of a kind of prevention and treatment tinea pedis, particularly a kind ofly have the foot odor of dispelling, remove sweaty foot, the lotion for tinea pedis of antipruritic, the tinea pedis of dispelling.

Along with the social civilization process; to tinea pedis; foot odor; the prevention of sweaty foot and treatment obtain the attention of society; people are constantly studying various Therapeutic Method and corresponding various medicine; as adopt Exocarpium Juglandis Immaturus to mash filtered juice; smear; Liquor Cortex Mori is smeared; catechu bitterroot soup soaks; and the Chinese and Western external patent medicine of listing sale; as tincture; xuanshi solution; Hang Kong foot liquid; ointment; ointment salicylic acid; miconazole etc.; though above-mentioned medicine has certain therapeutic effect to this pertinacious disease of tinea pedis; but Exocarpium Juglandis Immaturus etc. use trouble, get the material difficulty and are difficult to form large-scale production.Zests such as Chinese and Western medicine for external use such as tincture are strong, big at the skin lesion area, when drug level is higher, the easily toxicity reflection after the generation drug absorption, ointment uses the same poison that medicine easily takes place to pay effect for the scytitis large tracts of land, now use various curing tinea pedis medicines in sum, all be when characteristic of disease is heavier, to be used for the treatment of use, and have certain poison and pay effect, and be difficult to accomplish tinea pedis, foot odor, sweaty foot etc. are treated and prevented.

The objective of the invention is to invent a kind of Chinese medicine preparation, tinea pedis, foot odor and sweaty foot are had the purpose of treatment and prevention, and have advantages such as easy to use, evident in efficacy, applied widely, cheap.

Chinese medicine preparation of the present invention is by Radix Sophorae Flavescentis 6-8 part, Cortex Phellodendri 6-7 part, Cortex Dictamni 5-6 part, 6 parts of Fructus Cnidiis, Rhizoma Smilacis Glabrae 6-8 part, 6 parts of the Fructus Kochiae, 6 parts of dried Alumens, 6 parts of Fructus Chaenomeliss, Herba Pogostemonis 6-8 part, Pericarpium Zanthoxyli 2-3 part, 0.125 part of composition of sodium benzoate.Above-mentioned prescription mainly adopts the treatment rule of traditional Chinese medical science heat clearing and damp drying, detoxifying and relieving itching, deodorization Shujin.

Radix Sophorae Flavescentis bitter cold in the side, the function heat clearing and damp drying is controlled erosion of vulva pruritus due to damp pathogen; The Cortex Phellodendri bitter cold, heat clearing and damp drying, eliminating fire and detoxication, the two plays the merit of heat clearing and damp drying altogether for principal agent.The Cortex Dictamni hardship is salty, cold, dispeiling pathogenic wind and removing dampness, heat-clearing and toxic substances removing, and merit is arrogated to oneself and controlled scabies, prurigo; Fructus Cnidii is arduous, temperature, dispeiling pathogenic wind and removing dampness, arrogate to oneself and control eczema pudendal pruritus, helps principal agent dampness to have antipruritic power concurrently.Sweet light, flat, the removing dampness and detoxicating of Rhizoma Smilacis Glabrae, sharp joint, the kind foot gas of controlling; Fructus Kochiae sweetness and bitterness, cold, clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching is specially controlled pruritus eczema, the merit of auxiliary principal agent removing dampness and detoxicating.Assistant is wet, cold with dried Alumen acid, dampness removing to stop itchin, removing dampness are held back skin ulcer, to control sepage, hidroschesis; The cydonic acid temperature, the damp eliminating Shujin, it is comfortable and specially control dry beriberi to wash the back with modern foot.Herba Pogostemonis suffering, tepor, damp eliminating, ward off dirtyly, help in the cold and cool medicine of group with the deodorant that not only dehumidified with green pepper, but also increase the gas of fragrance, and can promote skin absorbs.Play heat clearing and damp drying, the merit of detoxifying and relieving itching is had the power of deodorization Shujin hidroschesis again.The selected medicine of the present invention has the inhibitory action to dermatophytes mostly, and antibacterial is had inhibitory action, and not the same to the antimicrobial spectrum of fungus and antibacterial between each medicine, each medicine effect intersects mutually behind the prescription, complementary inhibitory effect makes the present invention have wider antimicrobial spectrum, has increased inhibitory effect.Thereby the present invention has stronger inhibitory action to fungus and the various bacteria brood body that causes tinea pedis.

Preparation method of the present invention is: the used medical material of will writing out a prescription is pulverized or is concocted by general decoction pieces requirement after identifying by " pharmacopeia " requirement quality standard.Then each medicine (except that Herba Pogostemonis, sodium benzoate) is put into extraction pot and add 7 times of water, immersion earlier 30 minutes decocts 2 times, fries in shallow oil for the first time for the second time to add 5 times in water in 1.5 hours, fries in shallow oil 1 hour, merges medical filtration, puts into concentration tank and is concentrated into 400-500ml.Herba Pogostemonis adds 3-5 and doubly measures ethanol, and airtight dipping extracts 5-7 day, with extracting liquid filtering, is blended into cooled upward liquid, and 95% ethanol of adding and last liquid equivalent, stirs evenly, and staticly settles 24 hours, draws supernatant, and surplus liquid filters.Merge supernatant and filtrate, ethanol is reclaimed in distilling under reduced pressure, and is concentrated into 250ml.Add sodium benzoate 1.25g, make sodium benzoate concentration reach 0.5%, filter, after the input sterilization, the medicine bottle packing of clean dried is behind high-pressure steam sterilization, promptly.

In preparation process of the present invention, general medicine adopts and decocts effective component extracting, and Herba Pogostemonis is hot fragrant according to its abnormal smells from the patient, contain volatile oil, the inhibitory effect of volatile loss and its leachate is greater than the modern pharmacological research of decocting liquid, so extract with alcohol dipping during decoction, both kept aromatic odor, and made it keep antibacterial efficacy efficiently again.

Adopt distilling under reduced pressure, purpose to be to make the medicinal liquid vaporization of seething with excitement at a lower temperature, make the medicine active ingredient, ensure drug quality in recovery ethanol and less loss when concentrated.Shorten distillation time simultaneously, improved distillation efficiency.

The present invention can directly smear the affected part, or the boiled water of heating is mixed with 10% concentration, immersion foot 20 minutes.

The present invention is refined by natural pure purification of tcm and forms, and does not contain ethanol etc. to the irritant chemical substance of skin, only adds the preservative sodium benzoate oral administration external and the better bacteriostasis of tool.Thereby this product is non-stimulated to skin, has no adverse reaction and toxic and side effects safety and effect.Sterilization is antibacterial, sclerosis ends the juice effect because of this product has pedal skin, so in order to prevent and treat tinea pedis, foot odor, sweaty foot significant curative effect is arranged.And because of the special aromatic odor of tool Herba Pogostemonis, with after make the dry and comfortable cleaning of foot's skin, fragrant odour, comfortable pleasant.

The present invention is through teaching hospital of Hebei Medical University, Xingtang County, Hebei province institute of traditional Chinese medicine clinic trial, in treatment to routine tinea pedis surplus 400 or secondary sense person, 1-2 (soaked 20 minutes with 10% concentration the course of treatment every day, 7 was 1 course of treatment), cure improvement rate and reach more than 90%, wherein the part patient is more after fungus is done in the laboratory and antibacterial culturing does not have positive reaction.Clinically do not see untoward reaction such as skin irritation, damage, allergy.

The present invention is through Hebei Prov. Health and Epidemic Prevention Station check [MA (89) amount recognize (Ji) word (Q0103) number], and the toxicity statement claims: its mouse oral acute toxicity testing (ID50) result: each treated animal does not have poisoning symptom and death.Conclusion: this is tried the true border of thing non-poisonous material by the classification of disinfection technology technical specification acute toxicity; Rabbit acute skin irritation test result: the skin irritation integration is 0.Conclusion: this is tried thing and is belonged to non-stimulated to rabbit skin stimulus intensity; The mouse Bone marrow cells micronucleus experiment conclusion: it is negative that this is tried the mouse Bone marrow cells micronucleus experiment.

The survey report conclusion: stock solution effect of the present invention 10 minutes reaches more than 90% escherichia coli, staphylococcus aureus bacteriostasis rate, and 50% diluent effect 20 minutes reaches more than 90% escherichia coli, staphylococcus aureus bacteriostasis rate; The present invention is through accelerated test, and stock solution effect 10 minutes reaches more than 90% the enterobacteria bacteriostasis rate, and 50% diluent effect 20 minutes reaches more than 90% the escherichia coli bacteriostasis rate.

The embodiment of the invention proves through clinical trial, has evident in efficacy, easy to use, cheap, nontoxic pair of advantage such as effect.

Claims (1)

1, a kind of lotion for tinea pedis is characterized in that described lotion for tinea pedis, is made up of following medicine: Radix Sophorae Flavescentis 6-8 part, Cortex Phellodendri 6-7 part, Cortex Dictamni 5-6 part, 6 parts of Fructus Cnidiis, Rhizoma Smilacis Glabrae 6-8 part, 6 parts of the Fructus Kochiae, 6 parts of dried Alumens, 6 parts of Fructus Chaenomeliss, Herba Pogostemonis 6-8 part, Pericarpium Zanthoxyli 2-3 part, 0.125 part of sodium benzoate.