CN1238341A - 高品质甜菊糖甙分离富集新工艺 - Google Patents
高品质甜菊糖甙分离富集新工艺 Download PDFInfo
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- CN1238341A CN1238341A CN 98111347 CN98111347A CN1238341A CN 1238341 A CN1238341 A CN 1238341A CN 98111347 CN98111347 CN 98111347 CN 98111347 A CN98111347 A CN 98111347A CN 1238341 A CN1238341 A CN 1238341A
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- CN
- China
- Prior art keywords
- glucoside
- quality
- glycoside
- stevioside
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000019202 steviosides Nutrition 0.000 title claims abstract description 17
- 229940013618 stevioside Drugs 0.000 title claims abstract description 10
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 title claims abstract description 10
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 title abstract description 8
- 238000000034 method Methods 0.000 title abstract description 8
- 229930182470 glycoside Natural products 0.000 claims abstract description 10
- 150000002338 glycosides Chemical class 0.000 claims abstract description 7
- -1 stevioside glycoside Chemical class 0.000 claims abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 24
- 229930182478 glucoside Natural products 0.000 claims description 20
- 150000008131 glucosides Chemical class 0.000 claims description 19
- 239000002994 raw material Substances 0.000 claims description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 238000005516 engineering process Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
- 238000010612 desalination reaction Methods 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 239000003456 ion exchange resin Substances 0.000 claims description 2
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 2
- 239000000047 product Substances 0.000 claims 2
- 239000000706 filtrate Substances 0.000 claims 1
- 238000007670 refining Methods 0.000 claims 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 abstract description 3
- 241000544066 Stevia Species 0.000 abstract description 2
- 244000228451 Stevia rebaudiana Species 0.000 abstract 3
- 235000006092 Stevia rebaudiana Nutrition 0.000 abstract 3
- 239000001512 FEMA 4601 Substances 0.000 abstract 2
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 abstract 2
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 abstract 2
- 235000019203 rebaudioside A Nutrition 0.000 abstract 2
- RKWHWFONKJEUEF-GQUPQBGVSA-O Cyanidin 3-O-glucoside Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 RKWHWFONKJEUEF-GQUPQBGVSA-O 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- OMHUCGDTACNQEX-OSHKXICASA-N Steviolbioside Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OMHUCGDTACNQEX-OSHKXICASA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- JLPRGBMUVNVSKP-AHUXISJXSA-M chembl2368336 Chemical compound [Na+].O([C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C([O-])=O)[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O JLPRGBMUVNVSKP-AHUXISJXSA-M 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
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- Seasonings (AREA)
- Saccharide Compounds (AREA)
Abstract
甜菊糖甙是由天然多年生草本植物甜菊叶中提取的物质，其中的主要成分有甜菊二糖甙(甙1)、甜菊甙(甙2)＊、菊甙B(甙3)和甜菊甙A(甙4)＊。衡量甜菊糖的品质标准是以甙4与甙2的比，以比值高为质好。本发明是将甙4与甙2＊之比在0.5～1.1比值基础上的甜菊糖甙，采用分离、富集的新工艺，获得了甙4与甙2＊比值达到2.5以上的甜菊糖甙，提高了产品品质，满足国内外市场的需求，可取得显著的经济效益。甙4＊Redaudioside A甙2＊Stevioside
Description
甜菊糖甙是由天然多年生草本植物甜菊叶中提取的甜味物质。我国近年来，每年都有几十万亩地的甜菊叶种植，由于其中95％以上是老品种，且品质不断退化。由其作为原料生产出的甜菊糖甙具体品质指标甙4与甙2之比的值仅在0.2～0.9之间(见图1)，因此价格低，销售不畅，影响农民种植积极性，造成工厂亏损等问题。
发明是用甙4与甙2之比在0.5～1.1的甜菊糖甙为原料，采用溶剂溶解原料、分离和富集的新工艺，提高甜菊糖甙的品质，产品品质为甙4与甙2的比值达到2.5倍以上(见图2)。其中的主要成分中文名称与英文名称对照如下：
| 色谱峰编号 | 中文简称 | 中文名称 | 英文名称 |
| ①②③④ | 甙1甙2甙3甙4 | 甜菊二糖甙甜菊甙甜菊甙B甜菊甙A | SteviolbiosideSteviosideRedaudioside BRedaudioside A |
本发明的新工艺实施后，可提高经济效益，解决种植和加工发展中的问题，拓展国内外市场的销售渠道。
本发明经查新无有关工艺的文献报导，属创造性的新工艺。
实例：
工艺步骤：
原料：甙4与甙2之比在0.5～1.1之间的甜菊甙
溶剂：去离子水
甲醇(80％以上)容器：500～700升反应罐一只
500～700升蒸馏罐一只机械设备：加液泵；真空吸滤设备；搅拌机等步骤： 将50～150kg原料加入反应罐；加入甲醇300～800溶解原料，搅拌10～40分钟，有大量沉淀物产生，静置20～60分钟后，将上层溶液经滤膜真空吸滤，滤入蒸馏罐。蒸去大部分甲醇后，加水50～300升，将甲醇蒸净，得到一次提取液。
在反应罐中再加300升甲醇搅拌10～40分钟，静置20～60分钟后，将上层溶液经滤膜真空吸滤，滤入蒸馏罐，蒸去大部分甲醇后，加水50～300升，将甲醇蒸净，得到二次提取液。
将两次提取的清液合并，用离子交换树脂脱盐，用活性碳脱色，得到清液。经喷雾干燥后，得白色粉状产品。得率：产品为35～65％。效果：产品的甙4与甙2之比大于2.5，总甙量95％以上。
Claims (5)
1．一种用甜菊糖甙为原料，能提高甜菊糖甙中甙4与甙2比值的工艺技术，其特征为通过溶解原料，分离及精制后得到高品质的甜菊糖甙。
2．根据权利要求1，其溶解溶剂为甲醇，搅拌时间在2小时之内。静置时间在2小时内。
3．根据权利要求2，其原料的溶液过滤采用膜真空吸滤器。
4．根据权利要求3所得的滤液，用离子交换树脂脱盐、用活性碳脱色。
5．根据权利要求2～权利要求4的工艺技术，所得的白色粉状产品，其得率为35～65％，产品中甙4与甙2之比值达到2.5以上，总甙量为95％以上的高品质甜菊糖甙。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98111347A CN1098860C (zh) | 1998-06-08 | 1998-06-08 | 高品质甜菊糖甙分离富集工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98111347A CN1098860C (zh) | 1998-06-08 | 1998-06-08 | 高品质甜菊糖甙分离富集工艺 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1238341A true CN1238341A (zh) | 1999-12-15 |
| CN1098860C CN1098860C (zh) | 2003-01-15 |
Family
ID=5221336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98111347A Expired - Fee Related CN1098860C (zh) | 1998-06-08 | 1998-06-08 | 高品质甜菊糖甙分离富集工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1098860C (zh) |
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|---|---|---|---|---|
| CN101856109A (zh) * | 2010-05-10 | 2010-10-13 | 济南汉定生物工程有限公司 | 一种组分为ra和stv的甜菊糖 |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| CN101591365B (zh) * | 2009-07-07 | 2011-12-28 | 天津美伦医药集团有限公司 | 分离高纯度甜菊糖甙stv的工艺 |
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| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
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| CN101200480B (zh) | 2006-12-15 | 2011-03-30 | 成都华高药业有限公司 | 莱鲍迪甙a的提取方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1112565A (zh) * | 1995-03-06 | 1995-11-29 | 北京市环境保护科学研究院 | 膜法组合技术提取甜菊甙工艺 |
-
1998
- 1998-06-08 CN CN98111347A patent/CN1098860C/zh not_active Expired - Fee Related
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