CN1237337A - Avermectin and ivermectin micro emulsion - Google Patents
Avermectin and ivermectin micro emulsion Download PDFInfo
- Publication number
- CN1237337A CN1237337A CN 99107712 CN99107712A CN1237337A CN 1237337 A CN1237337 A CN 1237337A CN 99107712 CN99107712 CN 99107712 CN 99107712 A CN99107712 A CN 99107712A CN 1237337 A CN1237337 A CN 1237337A
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- Prior art keywords
- avermectin
- cosolvent
- ivermectin
- wei
- deionized water
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Abstract
The invented microemulsion insecticide for preventing and curing various mites, aphides of crops of fruit, vegetable and cotton, etc., American otitid and internal parasite of domestic animals is made up by using (wt%) 0.1-5.0% of avermectin or ivermectin, 4-20% of emulsifying agent, 0.1-2.0% of synergist, 5-30% of cosolvent, 0.1-1.0% of stabilizing agent and a proper quantity of deionized water, and features high-efficiency, low-toxicity and less dosage. Said invention also can be made into miticide and nematicide.
Description
The present invention relates to a kind of A Wei, Yi Wei micro emulsion insecticide, miticide, nematocide of preventing and treating insects such as the various insects of crops, mite class, tame carcass interior lines worm, it is a kind of by A Wei or the former powder of Yi Wei (or its syrup), emulsifier, synergist, cosolvent, stabilizing agent, deionized water etc. to say so in more detail, the water base microemulsion as insecticide-miticide of efficient, the low toxicity that processes with the PIT emulsifying process.
At present, the insect such as various insects, mite class that is used for crops such as fruit tree, wheat, paddy rice, peanut, cotton, vegetables is Avermectin or ivermectin cream preparation more effectively, and control efficiency is good, but cost is too high, drift is big during use, permeability is relatively poor, and residual effect is shorter.
The objective of the invention is to overcome the deficiency of above-mentioned existing procucts, and provide that the former dose of a kind of usefulness is few, with low cost, drift is little, permeability is strong during dispenser microemulsion as insecticide-miticide.
Purpose of the present invention can realize by following measure:
In reactor, add successively:
(a) weight concentration is Avermectin or the ivermectin of 0.1-5.0%;
(b) weight concentration is the emulsifier of 4-20%;
(c) weight concentration is the synergist of 0.1-2.0%;
(d) weight concentration is the cosolvent of 5-30%;
(e) weight concentration is the stabilizing agent of 0.1-1.0%;
The rest is deionized water.
Purpose of the present invention can also realize by following measure:
Adding a certain amount of cosolvent in A Wei or former powder of Yi Wei or the syrup (active constituent content 3-7%), be heated to 80-95 ℃, in (the rotating speed 200-400 rev/min) process of stirring, add emulsifier, temperature remains on 90-96 ℃, add hot deionized water (temperature 95-100 ℃) then, stirred 30-60 minute, add surplus cosolvent, synergist and stabilizing agent again, emulsion is converted into clear solution automatically in cooling procedure then, be chilled to about 30 ℃, leave standstill then, filter, pack and promptly get agricultural chemicals of the present invention.
The molecular structure of the Avermectin of using among the present invention is:
R wherein
1=H, R
2=C
2H
5B
1a
R
1=H,R
2=CH
3??B
1b
Avermectin (Avermectin) is the macrolides farm antibiotics that is produced by streptomycete, and its main active is B
1Component; Ivermectin (Ivermectin) is two hydrogenation Avermectin, and stability is better, and insecticidal activity and Avermectin are suitable.
Used emulsifier is to be formed according to 75/5/20 ratio is composite by anion surfactant, cationic surfactant and deionized water among the present invention.
Used cosolvent is made up of one-components such as higher aliphatic, PVP, ether, polyalcohols among the present invention, has height and oozes, helps emulsification function and can antifreeze, froth breaking, increases the stability of system simultaneously.
Used synergist is Butacide, Octacide 264 etc. among the present invention.
Used stabilizing agent is ultra-violet absorber, DMF etc. among the present invention.
The present invention give further instruction in order to illustrate better below by embodiment:
Embodiment 1:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, add purity and be 90% A Wei or the former powder of the Yi Wei syrup of effective composition (or contain) 1.11 grams, add 9 gram cosolvents, be heated to 80-90 ℃, stirred 10 minutes, treat dissolving evenly after, begin to drip emulsifier, totally 15 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 90-98 ℃ of deionized water 650 grams then, 300 gram cosolvents and the 10 gram synergist of adding during to 30-40 ℃ to be cooled, the 15g stabilizing agent, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
Embodiment 2:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, add purity and be 4.5% contain A Wei syrup 25.35 grams, add 50 gram cosolvents, be heated to 80-90 ℃, stirred 10 minutes, treat dissolving evenly after, begin to drip emulsifier, totally 80 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 90-98 ℃ of deionized water 500 grams then, 300 gram cosolvents and the 20 gram synergist of adding during to 30-40 ℃ to be cooled, 25 gram stabilizing agents, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
Embodiment 3:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, add purity and be 90% A Wei or the former powder of the Yi Wei syrup of effective composition (or contain) 1.24 grams, add 10 gram cosolvents, be heated to 80-90 ℃, stirred 10 minutes, treat dissolving evenly after, begin to drip emulsifier, totally 15 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 90-98 ℃ of deionized water 650 grams then, 310 gram cosolvents and the 8 gram synergist of adding during to 30-40 ℃ to be cooled, 18 gram stabilizing agents, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
The effect of pesticide control diamond-back moth of the present invention is as shown in table 1:
Table 1
| Handle | Liquor strength (ppm) | The investigation borer population | Preventive effect (%) | Average preventive effect (%) |
| Embodiment 1 | ????500 | ????500 | ????91.6 | ????93.3 |
| ????667 | ????500 | ????93.0 | ||
| ????1000 | ????500 | ????95.2 | ||
| Embodiment 2 | ????500 | ????500 | ????93.2 | ????95.5 |
| ????667 | ????500 | ????95.4 | ||
| ????1000 | ????500 | ????97.9 | ||
| Embodiment 3 | ????500 | ????500 | ????94.0 | ????96.6 |
| ????667 | ????500 | ????97.8 | ||
| ????1000 | ????500 | ????98.0 | ||
| 5% high chloro milk oil | ????120 | ????500 | ????90.2 | ????93.0 |
| ????150 | ????500 | ????94.8 | ||
| ????200 | ????500 | ????96.0 | ||
| 0.9% abamectin emulsifiable concentrate | ????200 | ????500 | ????98.0 | ????98.7 |
| ????400 | ????500 | ????98.8 | ||
| ????1000 | ????500 | ????99.2 |
The effect of pesticide control European red mite of the present invention is as shown in table 2:
Table 2
| Handle | Liquor strength (ppm) | Average relative control effect (%) | ||
| After 1 day | After 10 days | After 20 days | ||
| Embodiment 1 | ????667 | ????95.2 | ????97.0 | ????98.0 |
| Embodiment 2 | ????667 | ????96.6 | ????97.4 | ????98.2 |
| Embodiment 3 | ????667 | ????96.0 | ????97.2 | ????97.6 |
| 0.9% A Wei missible oil | ????400 | ????98.8 | ????99.2 | ????100.0 |
| Remarks | In one month, quantum of rainfall adds up 174 millimeters after the medication | |||
AVM of the present invention, ivermectin micro emulsion are compared with existing similar agricultural chemicals and are had the following advantages:
1, efficient, low toxicity, easy to use, safe;
But 2 pest controls, mite class etc.;
3, the resistant insects such as diamondback moth, pear sucker, bollworm also there is good preventive and therapeutic effect;
4, cost is low, can alleviate peasant's burden;
5, formulation is advanced, take water as solvent, and storing safety;
6, can substitute the various formulations of the AVM that uses at present fully.
Claims (4)
1, a kind of Avermectin or ivermectin novel form of efficient, low toxicity wherein contain Avermectin or ivermectin, emulsifier, synergist, cosolvent, stabilizing agent and deionized water, it is characterized in that:
(a) weight concentration is Avermectin or the ivermectin of 0.1-5.0%;
(b) weight concentration is the emulsifier of 4-20%;
(c) weight concentration is the synergist of 0.1-2.0%;
(d) weight concentration is the cosolvent of 5-30%;
(e) weight concentration is the stabilizing agent of 0.1-1.0%;
Surplus is a deionized water.
2, require described Avermectin or ivermectin micro emulsion insecticide according to right 1, adopted the manufacturing technology of nano particle emulsion, it is characterized in that adding a certain amount of cosolvent in A Wei or former powder of Yi Wei or the syrup (active constituent content 3-7%), be heated to 80-95 ℃, in whipping process, add emulsifier, temperature remains on 90-96 ℃, add hot deionized water (temperature 95-100 ℃) then, stirred 30-60 minute, add the surplus cosolvent again, synergist and stabilizing agent, emulsion is converted into clear solution automatically in cooling procedure then, is chilled to about 30 ℃, leaves standstill then, filter, packing.
3, require described A Wei or Yi Wei micro emulsion insecticide according to right 1, used emulsifier is made up of according to 75/5/20 anionic species surfactant, cationic surfactant, deionized water when making the liquid nanometer particle.
4, require described imidacloprid emulsion according to right 1, used cosolvent is by C in the manufacture process
2-C
8Class alcohol, pure ethers are formed as one-components such as butyl glycol ether, propylene glycol monomethyl ether, diglycol etc., DMF, N-Methyl pyrrolidone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99107712 CN1237337A (en) | 1999-05-26 | 1999-05-26 | Avermectin and ivermectin micro emulsion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99107712 CN1237337A (en) | 1999-05-26 | 1999-05-26 | Avermectin and ivermectin micro emulsion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1237337A true CN1237337A (en) | 1999-12-08 |
Family
ID=5272891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99107712 Pending CN1237337A (en) | 1999-05-26 | 1999-05-26 | Avermectin and ivermectin micro emulsion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1237337A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004026033A1 (en) * | 2002-09-20 | 2004-04-01 | Artpharm Pty Ltd | Plant pesticides and uses thereof |
| CN1933856B (en) * | 2004-03-18 | 2010-12-08 | 盖尔德玛公司 | Cream-gel containing ivermectin |
| CN103478144A (en) * | 2013-09-26 | 2014-01-01 | 卞佳林 | Avermectin and griseofulvin composite pesticidal nanoemulsion |
| CN104202976A (en) * | 2012-04-04 | 2014-12-10 | 先正达参股股份有限公司 | Pesticidal composition |
| CN104430394A (en) * | 2014-10-20 | 2015-03-25 | 广西大学 | Preparation method of ivermectin/emamectin benzoate compound microcapsule suspension |
| CN109984995A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of ivermectin nanoemulsion injection and preparation method thereof |
| CN115227645A (en) * | 2022-08-03 | 2022-10-25 | 上虞颖泰精细化工有限公司 | Antiparasitic solution preparation containing ivermectin and neonicotinoid insecticides and preparation method thereof |
-
1999
- 1999-05-26 CN CN 99107712 patent/CN1237337A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004026033A1 (en) * | 2002-09-20 | 2004-04-01 | Artpharm Pty Ltd | Plant pesticides and uses thereof |
| CN1933856B (en) * | 2004-03-18 | 2010-12-08 | 盖尔德玛公司 | Cream-gel containing ivermectin |
| CN104202976A (en) * | 2012-04-04 | 2014-12-10 | 先正达参股股份有限公司 | Pesticidal composition |
| CN103478144A (en) * | 2013-09-26 | 2014-01-01 | 卞佳林 | Avermectin and griseofulvin composite pesticidal nanoemulsion |
| CN103478144B (en) * | 2013-09-26 | 2015-09-09 | 卞佳林 | A kind of Avermectin and griseofulvin composite pesticidal nanoemulsion |
| CN104430394A (en) * | 2014-10-20 | 2015-03-25 | 广西大学 | Preparation method of ivermectin/emamectin benzoate compound microcapsule suspension |
| CN109984995A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of ivermectin nanoemulsion injection and preparation method thereof |
| CN109984995B (en) * | 2017-12-29 | 2021-09-07 | 瑞普（天津）生物药业有限公司 | Ivermectin nanoemulsion injection and preparation method thereof |
| CN115227645A (en) * | 2022-08-03 | 2022-10-25 | 上虞颖泰精细化工有限公司 | Antiparasitic solution preparation containing ivermectin and neonicotinoid insecticides and preparation method thereof |
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