CN1237342A - Avermectin or ivermectin and high-effective chlorocyanogen micro emulsion - Google Patents
Avermectin or ivermectin and high-effective chlorocyanogen micro emulsion Download PDFInfo
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- CN1237342A CN1237342A CN 99107713 CN99107713A CN1237342A CN 1237342 A CN1237342 A CN 1237342A CN 99107713 CN99107713 CN 99107713 CN 99107713 A CN99107713 A CN 99107713A CN 1237342 A CN1237342 A CN 1237342A
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- microemulsion
- avermectin
- cosolvent
- weight concentration
- ivermectin
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Abstract
The present invention relates to a micro-emulsion for preventing and curing various mites of crops of fruit, vegetable and cotton, etc., pests, American otitid, cotton bollworm and pear psyllid, etc.. It is made up by using (wt%) 0.01-0.05% of avermection or ivermectin, 1.0-4.0% of high-effective cypermethrin, 4-20% of emulsifying agent, 0.1-2.0% of synergist, 5-28% of cosolvent, 0.1-1.0% of stabilizing agent and a proper quantity of deionized water through a certain preparation process. It can be made into the high-effective pesticide, miticide and nematicide, and features high-efficiency, low toxicity and less dosage.
Description
The present invention relates to a kind of A Wei, Yi Wei micro emulsion insecticide, miticide, nematocide of preventing and treating insects such as the various insects of crops, mite class, tame carcass interior lines worm, it is a kind of by A Wei or the former powder of Yi Wei (or its syrup) and efficient chlorine cyanogen, emulsifier, synergist, cosolvent, stabilizing agent, deionized water etc. to say so in more detail, with the PIT emulsifying process process efficiently, the water base microemulsion as insecticide-miticide of low toxicity.
At present, the insect such as various insects, mite class that is used for crops such as fruit tree, wheat, paddy rice, peanut, cotton, vegetables is Avermectin or ivermectin cream preparation and high chloro milk oil more effectively, control efficiency is good, but cost is too high, drift is big during use, permeability is relatively poor, and residual effect is shorter.
The objective of the invention is to overcome the deficiency of above-mentioned existing procucts, and provide that the former dose of a kind of usefulness is few, with low cost, drift is little, permeability is strong during dispenser microemulsion as insecticide-miticide.
Purpose of the present invention can realize by following measure:
In reactor, add successively:
(a) weight concentration is Avermectin or the ivermectin of 0.01-0.05%;
(b) weight concentration is the beta-cypermethrin of 1.0-4.0%;
(c) weight concentration is the emulsifier of 4-20%;
(d) weight concentration is the synergist of 0.1-2.0%;
(e) weight concentration is the cosolvent of 5-28%;
(f) weight concentration is the stabilizing agent of 0.1-1.0%;
The rest is deionized water.
Purpose of the present invention can also realize by following measure:
Adding a certain amount of cosolvent in A Wei or the former powder of Yi Wei or syrup (active constituent content 3-7%) and the high chlorine, be heated to 80-85 ℃, in (the rotating speed 200-400 rev/min) process of stirring, add emulsifier, temperature remains on 85-90 ℃, add hot deionized water (temperature 95-98 ℃) then, stirred 30-60 minute, add surplus cosolvent, synergist and stabilizing agent again, emulsion is converted into clear solution automatically in cooling procedure then, be chilled to about 30 ℃, leave standstill then, filter, pack and promptly get agricultural chemicals of the present invention.
The molecular structure of the Avermectin of using among the present invention is:
R wherein
1=H, R
2=C
2H
5B
1a
R
1=H,R
2=CH
3??B
1b
Avermectin (Avermectin) is the macrolides farm antibiotics that is produced by streptomycete, and its main active is B
1Component; Ivermectin (Ivermectin) is two hydrogenation Avermectin, and stability is better, and insecticidal activity and Avermectin are suitable.
The molecular structure of the beta-cypermethrin that uses among the present invention (Alphamethrin) is:
Cypermethrin can generate dichloro chrysanthemum acyl chlorides with dichlor chrysanthemic acid after chloride, promptly get cypermethrin with ether aldehyde and Cymag reaction then, and again that it is suitable, trans isomer separation obtains efficient (cis) cypermethrin.
Used emulsifier is to be formed according to 70/10/20 ratio is composite by anion surfactant, cationic surfactant and deionized water among the present invention.
Used cosolvent is made up of one-components such as higher aliphatic, PVP, ether, polyalcohols among the present invention, has height and oozes, helps emulsification function and can antifreeze, froth breaking, increases the stability of system simultaneously.
Used synergist is ten thousand spirits (Methomyl), granville carbosulfan etc. among the present invention.
Used stabilizing agent is ultra-violet absorber, DMF etc. among the present invention.
The present invention give further instruction in order to illustrate better below by embodiment:
Embodiment 1:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, add purity and be 90% A Wei or the former powder of the Yi Wei syrup of effective composition (or contain) 0.22 gram, 90% high chlorine 22.2 grams, add 30 gram cosolvents, be heated to 80-85 ℃, stirred 10 minutes, after treating dissolving evenly, begin to drip emulsifier, totally 65 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 95-98 ℃ of deionized water 560 grams then, 300 gram cosolvents and the 15 gram synergist of adding during to 30-40 ℃ to be cooled, 8 gram stabilizing agents, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
Embodiment 2:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, add purity and be 4.5% contain A Wei syrup 2.54 grams, 90% high chlorine 22.2 grams, add 30 gram cosolvents, be heated to 80-85 ℃, stirred 10 minutes, after treating dissolving evenly, begin to drip emulsifier, totally 80 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 95-98 ℃ of deionized water 500 grams then, 330 gram cosolvents and the 20 gram synergist of adding during to 30-49 ℃ to be cooled, 15 gram stabilizing agents, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
Embodiment 3:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, adding purity is 90% A Wei or former powder 1.11 grams of Yi Wei, 90% high chlorine 10 grams, add 15 gram cosolvents, be heated to 80-85 ℃, stirred 10 minutes, after treating dissolving evenly, begin to drip emulsifier, totally 45 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 95-98 ℃ of deionized water 600 grams then, 300 gram cosolvents and the 20 gram synergist of adding during to 30-40 ℃ to be cooled, 9 gram stabilizing agents, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
The effect of pesticide control diamond-back moth of the present invention is as shown in table 1:
Table 1
| Handle | Liquor strength (ppm) | The investigation borer population | Preventive effect (%) | Average preventive effect (%) |
| Embodiment 1 | ????333 | ????1000 | ????94.6 | ????96.6 |
| ????500 | ????1000 | ????97.0 | ||
| ????667 | ????1000 | ????98.2 | ||
| Embodiment 2 | ????333 | ????1000 | ????95.2 | ????97.5 |
| ????500 | ????1000 | ????98.4 | ||
| ????667 | ????1000 | ????98.9 | ||
| Embodiment 3 | ????333 | ????1000 | ????94.0 | ????95.9 |
| ????500 | ????1000 | ????96.8 | ||
| ????667 | ????1000 | ????97.0 | ||
| 4% high chlorine microemulsion | ????333 | ????1000 | ????95.2 | ????96.7 |
| ????500 | ????1000 | ????96.8 | ||
| ????667 | ????1000 | ????98.0 | ||
| 0.9% abamectin emulsifiable concentrate | ????200 | ????1000 | ????97.0 | ????98.4 |
| ????400 | ????1000 | ????98.2 | ||
| ????667 | ????1000 | ????100.0 |
The effect of pesticide control European red mite of the present invention is as shown in table 2:
Table 2
| Handle | Liquor strength (ppm) | Average relative control effect (%) | ||
| After 1 day | After 10 days | After 20 days | ||
| Embodiment 1 | ????500 | ????96.2 | ????97.4 | ????98.8 |
| Embodiment 2 | ????500 | ????97.6 | ????98.4 | ????99.2 |
| Embodiment 3 | ????500 | ????98.0 | ????99.2 | ????98.6 |
| 0.9% A Wei missible oil | ????400 | ????98.9 | ????100.0 | ????100.0 |
| Remarks | In one month, quantum of rainfall adds up 274 millimeters after the medication | |||
AVM of the present invention or ivermectin are compared with existing similar agricultural chemicals with high-effective chlorocyanogen micro emulsion and are had the following advantages:
1, efficient, low toxicity, easy to use, safe;
But 2 pest controls, mite class etc.;
3, interfacial tension ultralow (＜0.01dyn/cm), the drug effect superelevation;
4, the resistant insects such as diamondback moth, pear sucker, bollworm also there is good preventive and therapeutic effect;
5, cost is low, can alleviate peasant's burden;
6, formulation is advanced, take water as solvent, and storing safety;
7, can substitute the AVM of at present use and the various formulations of high chlorine fully.
Claims (4)
1, a kind of microemulsion novel form of the efficient chlorine cyanogen of Avermectin of efficient, low toxicity wherein contains Avermectin or ivermectin, efficient chlorine cyanogen, emulsifier, synergist, cosolvent, stabilizing agent and deionized water, it is characterized in that:
(a) weight concentration is Avermectin or the ivermectin of 0.01-0.05%;
(b) weight concentration is the beta-cypermethrin of 1.0-4.0%;
(c) weight concentration is the emulsifier of 4-20%;
(d) weight concentration is the synergist of 0.1-2.0%;
(e) weight concentration is the cosolvent of 5-28%;
(f) weight concentration is the stabilizing agent of 0.1-1.0%;
Surplus is a deionized water.
2, require described Avermectin or ivermectin and beta-cypermethrin microemulsion as insecticide-miticide according to right 1, adopted the manufacturing technology of o/w microemulsion, it is characterized in that adding a certain amount of cosolvent in A Wei or the former powder of Yi Wei or syrup (active constituent content 3-7%) and the high chlorine, be heated to 80-85 ℃, in whipping process, add emulsifier, temperature remains on 85-90 ℃, add hot deionized water (temperature 95-98 ℃) then, stirred 30-60 minute, add the surplus cosolvent again, synergist and stabilizing agent, emulsion is converted into clear solution automatically in cooling procedure then, is chilled to about 30 ℃, leaves standstill then, filter, packing.
3, require described A Wei or Yi Weigao chlorine microemulsion as insecticide-miticide according to right 1, used emulsifier is made up of according to 70/10/20 anionic species surfactant, cationic surfactant, deionized water when making microemulsion.
4, require described Ah high's microemulsion according to right 1, used cosolvent is by C in the manufacture process
2-C
6Class alcohol, pure ethers are formed as one-components such as butyl glycol ether, propylene glycol monomethyl ether, propylene-glycol ethyl ether etc., DMF, N-Methyl pyrrolidone
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99107713 CN1237342A (en) | 1999-05-26 | 1999-05-26 | Avermectin or ivermectin and high-effective chlorocyanogen micro emulsion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99107713 CN1237342A (en) | 1999-05-26 | 1999-05-26 | Avermectin or ivermectin and high-effective chlorocyanogen micro emulsion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1237342A true CN1237342A (en) | 1999-12-08 |
Family
ID=5272892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99107713 Pending CN1237342A (en) | 1999-05-26 | 1999-05-26 | Avermectin or ivermectin and high-effective chlorocyanogen micro emulsion |
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| Country | Link |
|---|---|
| CN (1) | CN1237342A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012078605A1 (en) * | 2010-12-07 | 2012-06-14 | Merial Limited | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| CN102669153A (en) * | 2012-01-05 | 2012-09-19 | 安徽迪邦药业有限公司 | 2.4% avermectin and chlorobenzene oil ointment |
| CN104272103A (en) * | 2012-03-08 | 2015-01-07 | 陶氏益农公司 | Organic colloid-stabilized emulsion for controlling pesticide spray drift |
| CN115428790A (en) * | 2022-10-21 | 2022-12-06 | 淮阴工学院 | Pesticide microemulsion with attapulgite clay and span 80 surfactant synergistically stabilized and preparation method thereof |
-
1999
- 1999-05-26 CN CN 99107713 patent/CN1237342A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012078605A1 (en) * | 2010-12-07 | 2012-06-14 | Merial Limited | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| AU2011338573B2 (en) * | 2010-12-07 | 2016-07-28 | Boehringer Ingelheim Animal Health USA Inc. | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| CN102669153A (en) * | 2012-01-05 | 2012-09-19 | 安徽迪邦药业有限公司 | 2.4% avermectin and chlorobenzene oil ointment |
| CN104272103A (en) * | 2012-03-08 | 2015-01-07 | 陶氏益农公司 | Organic colloid-stabilized emulsion for controlling pesticide spray drift |
| CN115428790A (en) * | 2022-10-21 | 2022-12-06 | 淮阴工学院 | Pesticide microemulsion with attapulgite clay and span 80 surfactant synergistically stabilized and preparation method thereof |
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