CN101019542B - Pesticide composition of abamectin and bisultap and preparation of its microemulsion - Google Patents
Pesticide composition of abamectin and bisultap and preparation of its microemulsion Download PDFInfo
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- CN101019542B CN101019542B CN2007100136317A CN200710013631A CN101019542B CN 101019542 B CN101019542 B CN 101019542B CN 2007100136317 A CN2007100136317 A CN 2007100136317A CN 200710013631 A CN200710013631 A CN 200710013631A CN 101019542 B CN101019542 B CN 101019542B
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- abamectin
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Abstract
The present invention relates to pesticide composition of abamectin and bisultap and the preparation of its microemulsion. The abamectin-bisultap composition is compounded with abamectin 0.1-5 wt%, bisultap 10-50 wt%, emulsifier 5-25 wt%, co-solvent 1-15 wt%, synergist 1-10 wt%, stabilizer 1-10 wt% and water for the rest. The abamectin-bisultap composition is prepared in microemulsion, which has lowered toxicity, environment friendship and low cost. The abamectin-bisultap composition has the advantages of high pesticidal activity, high effect, low toxicity, broad pesticidal spectrum, high safety, etc.
Description
One, technical field
The present invention relates to the preparation method of Avermectin and dimehypo compounded pesticides and microemulsion thereof, belong to insecticide and preparation method thereof technical field.
Two, background technology
Avermectin is a kind of antibiotics insecticidal/acaricidal agent, have tag, stomach toxicity and very strong osmosis.Its insecticidal mechanism mainly is y-aminobutyric acid (GABA) system that acts on insect synapse or neuromuscular synapse, cause neu to be in holddown, thereby the block nerves impulse conduction makes insect paralysis, food refusal, death.Avermectin is all effective to common Lepidoptera, coleopteran pest and evil mite, but its mode of action is single, the long-term use continuously causes many insects (mite) that its susceptibility is reduced, the resistant multiple increases year by year, it is reported, insects such as diamond-back moth, housefly, colorado potato beetle, Cockroach, liriomyza bryoniae have all produced certain pesticide resistance to Avermectin, wherein indoor to the diamond-back moth resistance eliminate selected for 13 generations after. resistance index can develop into 93.55 times high anti-level before the seed selection.
Dimehypo is the similar thing insecticide of nereistoxin that China develops voluntarily, have tag, stomach toxicity and certain fumigation action.Its mechanism of action is that blocking-up insect nerve impulse is transmitted, and the blockage of acetylcholine receiver makes insect lose regulative mechanism, is absorbed in paralysis, food refusal and dying.Insects such as the striped rice borer on the main control paddy rice, paddy stem borer, rice leaf roller, thrips, leafhopper, at the rarely seen use report of other most crops, range of application and insecticidal spectrum are narrower, and quick-acting is relatively poor.
Apple apple leaf miner (Lithocolletis ringoniella Matsumura) is the rampant always a kind of important leaf mining insect of taking place in northern apple producing region for many years, the control difficulty, in the production always with process for preparation of benzoylurea compounds, as the young urea that goes out, diflubenzuron, fluorine bell urea etc. are as main control medication, owing to use year after year, pest resistance to insecticide constantly strengthens, and causes in recent years that the preventive effect of this type of medicament keeps falling, some areas in addition show invalid.Therefore, the control at leaf mining insects such as apple leaf miners faces the present situation that no special effect agent can be used.The present inventor is through discovering for many years, Avermectin, dimehypo all show insecticidal activity to apple leaf miner, two kinds of medicament mechanism of action uniquenesses, there is not mutual pesticide resistance, can obviously increase the application point of medicine after composite to insect, improving insecticidal activity greatly, thereby produce synergistic effect, is one of effective way of resisting resistance, delaying drug resistance development.
Microemulsion is a kind of new and effective, environmental protection formulation.With water is matrix, has reduced the production cost of agricultural chemicals, has alleviated environmental pollution, and to the development green agriculture, it is significant to keep the ecological balance.Its micella particle diameter is less than optical wavelength, grain fineness is little, auxiliary agent content height, so the opening up of soup, infiltration, wetting, filming function all be better than cream preparation and suspending agent, effective rate of utilization and drug effect improve more than 20% than missible oil, suspending agent and the pulvis of same dose.And domestic and international most of Avermectin product forms mostly is missible oil at present, and environmental pollution is heavy, and environmental administration launches monitoring to the Pesticidal products that this type of contains harmful aromatic solvent.
Three, summary of the invention
The objective of the invention is to use the deficiency that exists separately separately at Avermectin and dimehypo, the comprehensive advantage that absorbs the two is also improved, a kind of the have two insecticides of abamectin pest killing of consonance effect and the preparation method of microemulsion thereof are provided, be mainly used in difficulty insects such as control apple apple leaf miner, simultaneously other Lepidopteras, diptera, Homoptera and evil mite had good control efficiency.
The technical solution that the present invention adopts is:
The two insecticides of abamectin pest killing, active ingredient comprise Avermectin and dimehypo composition, and preparation of compositions raw material weight per distribution ratio is Avermectin 0.1～5%, dimehypo 10～50%, the additive surplus.
The formulation of the two insecticides of abamectin pest killing adopts microemulsion, with a large amount of inflammable benzene class organic solvents of water replacement, reduces product toxicity and production cost, improves the safety of producing and storing and transporting;
By surfactant and add synergist and improve the opening up of medicament, wetting, infiltration, film forming, improve the effective rate of utilization of agricultural chemicals.Wherein also comprise, according to the raw material weight per distribution ratio, emulsifier 5～25%, cosolvent 1～15%, synergist 1～10%, stabilizing agent 1～10%, excess water.
The emulsifier that the present invention is fit to is selected from one or more the compound in alkylphenol polyoxyethylene series, triphen ethyl-phenol polyoxy third rare polyoxyethylene blocks polymer, castor oil polyoxyethylene ether series, phenethyl phenol polyethenoxy ether yuban, cumenyl phenol polyethenoxy ether, the dodecyl benzene sulfonate.
The cosolvent that the present invention is fit to be selected from methyl alcohol, n-butanol, acetone, cyclohexanone, DMF, n-formyl sarcolysine base pyrrolidones have similar features or the material of performance in any one or two kinds of above compositions.
The synergist that the present invention is fit to be selected from Butacide, synergy phosphorus, Octachlorodipropyl Ether, azone, thiophene ketone, fatty alcohol-polyoxyethylene ether, ethyl sorbate, trimethicone have similar features or the surface reactive material of performance in one or more composition.
The stabilizing agent that the present invention is fit to be selected from ethylene glycol, polyethylene glycol, glycerine, benzoate, xanthans have similar characteristic or the material of performance in any one or two kinds of above compositions.
The wet concentration that the present invention is fit to any one in running water, underground water, deionized water, distilled water.
The preparation method of insecticides microemulsion is:
1, according to said ratio weighing Avermectin, dimehypo and additive raw material;
2, earlier Avermectin is dissolved in the middle of the cosolvent with ointment, adds emulsifier, add or do not add synergist, add or do not add stabilizing agent, add dimehypo water solution then, stir;
3, slowly supply excess water, be stirred well to even phase transparency liquid, promptly obtain the two microemulsions of abamectin pest killing.
The present invention adopts Avermectin and dimehypo to carry out composite, has the notable synergistic effect, widened the scope of application simultaneously, enlarged insecticidal spectrum, and the two no cross resistance can effectively delay the drug-fast generation of insect (mite), is mainly used in to prevent and treat all kinds of worms (mite) evil that takes place on the multiple kinds of crops, especially the difficulty insects such as apple apple leaf miner to current control difficulty show extremely strong insecticidal activity, are different from existing other agricultural chemical insecticides.
This combination pest killing micro emulsion applied range all can use on most crops, and safety is good, and cost is low, and preventive effect is remarkable.Prove that after tested preparation chemical property of the present invention is stable, complementary synergy is remarkable, and target pest is shown synergistic effect.Using method is for converting water spray, and is different with controlling object because of crop with concentration, is generally 200～800 μ g/ml.
The advantage of this insecticides and micro emulsion formulation thereof:
1, two kinds of combination of active principles are used, controlling object enlarges, range of application and insecticidal spectrum obviously enlarge, the various pests (mite) that takes place on the crops such as apple, grape, pear tree, banana, corn, wheat, paddy rice, vegetables all had good preventive effect, especially remarkable to apple apple leaf miner preventive effect, filled up the blank that this class pest of current control does not have efficient medicament.Overcome the shortcoming of single agent quick-acting difference, for example to 1 day preventive effect of rice-stem borer, the agent of dimehypo list is 70%, and mixture is increased to 85%, and the lasting period has prolonged about 5 days than dimehypo.In addition, two kinds of medicaments do not have cross resistance, and the insect individuality that single agent is produced resistance is responsive to the composition performance, and the more single agent of the mode of action and site obviously increases, thereby have delayed the drug-fast generation of insect (mite).
2, synergistic effect is remarkable.Avermectin, dimehypo use apple leaf miner larva virulence EC separately
50Be respectively 1.52 μ g/ml, 1.14 μ g/ml, and be used in combination EC with weight percent proportioning Avermectin 0.1～5%, dimehypo 10～50%
50All less than 1.0 μ g/ml, co-toxicity coefficient CTC all greater than 154 (lethane biologicall test GB NY/T1154.7-2006 regulation, CTC 〉=120 show as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action), mixed synergies is remarkable.Field trial tentatively proves, the two microemulsions of 20% abamectin pest killing to the rice-stem borer medicine after 15 days preventive effects improve about 30% than 20% dimehypo water solution, improve 35% than 1.8% abamectin emulsifiable concentrate preventive effect, synergy is obvious.
3, adopt the micro emulsion formulation, reduce the use of organic solvent in a large number, reduced production cost and to the pollution of environment, product is nonflammable, and is non-explosive, produce, storing safety.The active ingredient particle diameter only was below 1/100 times of cream preparation after medicament was converted water, and is extremely strong to the penetration capacity of target insect; The wettability of soup improves 20～30 times than missible oil, and the soup plate-out ability is good, the effective rate of utilization height; Drug effect obviously is better than missible oil and suspension formulation.Because of it is a matrix with water, alleviated that organic solvent has improved safety in utilization to the injury of young fruit and tender leaf in the cream preparation; Free from extraneous odour during sprinkling has reduced the injury to the user.
Four, embodiment
Below in conjunction with embodiment the present invention is made more specific description, but embodiment does not limit the present invention, the percentage among the embodiment is mass percent.
Embodiment 1
The two microemulsions of 20% abamectin pest killing
Avermectin 0.1%
Dimehypo 19.9%
Cyclohexanone 5%
DMF 5％
BRT-11 15％
Water adds to 100%
The preparation method: after the former medicinal cyclohexanone dissolving of Avermectin, add DMF, the back that stirs adds the dimehypo aqueous solution to standard content 19.8%, adds the BRT-11 emulsifier again, stirs, and slowly adds excess water, is stirred well to even phase transparency liquid.
Embodiment 2
The two microemulsions of 12% abamectin pest killing
Avermectin 2%
Dimehypo 10%
Cyclohexanone 5%
DMF 5％
BRT-1 115％
601 emulsifier 2%
Water adds to 100%
The preparation method: after the former medicinal cyclohexanone dissolving of Avermectin, add DMF, the back that stirs adds the dimehypo aqueous solution to standard content 20%, adds BRT-11 and 601 emulsifier, stirs, and slowly adds excess water, is stirred well to even phase transparency liquid.
Embodiment 3
The two microemulsions of 30% abamectin pest killing
Avermectin 5%
Dimehypo 25%
Isopropyl alcohol 8%
DMF 5％
BRT-11 15％
Farming breast 500 5%
Water adds to 100%
Embodiment 4
The two microemulsions of 41% abamectin pest killing
Avermectin 1%
Dimehypo 40%
Cyclohexanone 8%
N-butanol 5%
BRT-11 15％
601 emulsifier 5%
Water adds to 100%
Embodiment 5
The two microemulsions of 45% abamectin pest killing
Avermectin 5%
Dimehypo 40%
Cyclohexanone 1%
N-butanol 10%
BRT-11 15％
601 emulsifier 5%
Water adds to 100%
Embodiment 6
The two microemulsions of 55% abamectin pest killing
Avermectin 5%
Dimehypo 50%
Cyclohexanone 10%
N-butanol 1%
BRT-11 15％
601 emulsifier 10%
Water adds to 100%
Embodiment 7
The two microemulsions of 33% abamectin pest killing
Avermectin 3%
Dimehypo 33%
Cyclohexanone 10%
N-butanol 8%
BRT-11 15％
601 emulsifier 5%
Water adds to 100%
The preparation method of embodiment 3-7 is identical with embodiment 1,2.
The microemulsion physicochemical property of preparation is as follows:
Outward appearance: faint yellow homogeneous phase transparent liquid
Transparency temperature zone :-5～60 ℃
Ageing stability: seasoning was stablized in 2 years under the normal temperature
Low-temperature stability :-10～0 ℃ of two week is not stratified, does not separate out, and be haze-free
Stability of emulsion: qualified (200 times of liquid)
Above embodiment adopts Avermectin and dimehypo to carry out composite, has the notable synergistic effect, widened the scope of application simultaneously, enlarged insecticidal spectrum, and the two no cross resistance can effectively delay the drug-fast generation of insect (mite), is mainly used in to prevent and treat all kinds of worms (mite) evil that takes place on the multiple kinds of crops, show extremely strong insecticidal activity, be different from existing other agricultural chemical insecticides.
This combination pest killing micro emulsion applied range all can use on most crops, and safety is good, and cost is low, and preventive effect is remarkable.Prove that after tested preparation chemical property of the present invention is stable, complementary synergy is remarkable, and target pest is shown synergistic effect.Using method is for converting water spray, and is different with controlling object because of crop with concentration, is generally 200～800 μ g/ml.
Claims (7)
1. the two insecticides of abamectin pest killing are in the application of control apple apple leaf miner leaf mining insect, the active ingredient of insecticides is Avermectin and dimehypo, the weight percent proportioning of the raw material of preparation composition is Avermectin 0.1～5%, dimehypo 10～50%, the additive surplus.
2. the application of the two insecticides of abamectin pest killing according to claim 1, it is characterized in that, insecticides is a microemulsion, according to the raw material weight per distribution ratio, it comprises Avermectin 0.1～5%, dimehypo 10～50%, emulsifier 5～25%, cosolvent 1～15%, synergist 1～10%, stabilizing agent 1～10%, excess water.
3. the application of the two insecticides of abamectin pest killing according to claim 2 is characterized in that emulsifier is selected from one or more the compound in alkylphenol polyoxyethylene series, triphen ethyl-phenol polyoxy third rare polyoxyethylene blocks polymer, castor oil polyoxyethylene ether series, phenethyl phenol polyethenoxy ether yuban, cumenyl phenol polyethenoxy ether, the dodecyl benzene sulfonate.
4. the application of the two insecticides of abamectin pest killing according to claim 2 is characterized in that cosolvent is selected from any one or two kinds of above compositions in methyl alcohol, ethanol, n-butanol, acetone, cyclohexanone, DMF, the n-formyl sarcolysine base pyrrolidones.
5. the application of the two insecticides of abamectin pest killing according to claim 2 is characterized in that synergist is selected from one or more the composition in Butacide, synergy phosphorus, Octachlorodipropyl Ether, azone, thiophene ketone, fatty alcohol-polyoxyethylene ether, ethyl sorbate, the trimethicone.
6. the application of the two insecticides of abamectin pest killing according to claim 2 is characterized in that stabilizing agent is selected from any one or two kinds of above compositions in ethylene glycol, polyethylene glycol, glycerine, benzoate, the xanthans.
7. the application of the two insecticides of abamectin pest killing according to claim 2 is characterized in that in running water, underground water, deionized water, distilled water any one of the wet concentration that is fit to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2007100136317A CN101019542B (en) | 2007-02-14 | 2007-02-14 | Pesticide composition of abamectin and bisultap and preparation of its microemulsion |
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| CN2007100136317A CN101019542B (en) | 2007-02-14 | 2007-02-14 | Pesticide composition of abamectin and bisultap and preparation of its microemulsion |
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| CN101019542A CN101019542A (en) | 2007-08-22 |
| CN101019542B true CN101019542B (en) | 2010-08-04 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103081927B (en) * | 2011-10-28 | 2014-07-23 | 叶长东 | Pesticide composition containing abamectin and nereistoxin insecticide |
| CN103229772B (en) * | 2013-03-07 | 2015-04-08 | 河南好年景生物发展有限公司 | Microcapsule suspending agent containing avermectin and dimehypo |
| CN107114385A (en) * | 2017-07-03 | 2017-09-01 | 安徽省鸿鑫生物科技有限公司 | A kind of composition pesticide |
| CN109730062A (en) * | 2018-12-29 | 2019-05-10 | 江苏康巴特生物工程有限公司 | A kind of water soluble insecticide and preparation method thereof containing Amitraz |
| CN111903686A (en) * | 2020-08-21 | 2020-11-10 | 安徽华星化工有限公司 | Pesticide compound mixture microemulsion containing dimehypo and fosthiazate and production method thereof |
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Non-Patent Citations (2)
| Title |
|---|
| 陈焕瑜等.几种化学农药对阿维菌素的增效作用.广东农业科学 4.2001,(4),第46-47页. |
| 陈焕瑜等.几种化学农药对阿维菌素的增效作用.广东农业科学 4.2001,(4),第46-47页. * |
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