CN101019542A - Pesticide composition of abamectin and bisultap and prepn of its microemulsion - Google Patents

Abstract

The invention relates to a preparation method of abamectin and dimehytap compound insecticide and microemulsion thereof. Abamectin · dimehypo insecticide composition is characterized in that the active ingredients include abamectin and dimehypo, and the weight percentage ratio of raw materials for preparation of the composition is 0.1-5% of abamectin and dimehypo 10-50%, the balance of additives. It also includes 5-25% of emulsifier, 1-15% of co-solvent, 1-10% of synergist, 1-10% of stabilizer and the balance of water. The dosage form is a microemulsion, which can not only reduce the toxicity of the product, be beneficial to environmental protection, but also reduce the cost of the product. The fungicidal composition has the advantages of high efficiency, low toxicity, broad spectrum, safety, etc., and exhibits strong insecticidal activity against various pests (mite), especially for difficult leaf miner pests such as apple goldenrod moth, which is different from There are other pesticides and insecticides, which can be widely used on various crops in the north and south, and can treat both insects and mites.

Description

Abamectin · dimehypo insecticide composition and preparation method of microemulsion

1. Technical field

The invention relates to a compound insecticide of avermectin and dimehytap and a preparation method thereof, and belongs to the technical field of insecticides and preparation methods thereof.

2. Background technology

Abamectin is an antibiotic insecticide and acaricide with contact killing, stomach toxicity and strong penetrating effect. Its insecticidal mechanism mainly acts on the gamma-aminobutyric acid (GABA) system of insect neuronal synapses or neuromuscular synapses, causing the neuromembrane to be in a state of inhibition, thereby blocking nerve impulse conduction and causing paralysis, food refusal, and death of insects. Abamectin is effective to common Lepidoptera, Coleoptera pests and pest mites, but its mode of action is single, and long-term continuous use causes many pests (mite) to reduce their sensitivity, and the resistance multiples increase year by year. Pests such as moth, housefly, potato beetle, German cockroach, and Liriomyza have developed certain resistance to abamectin. Among them, after 13 generations of indoor selection for resistance to diamondback moth, the resistance index can be developed to the selected level. 93.55 times the high resistance level before breeding.

Dimehypo is a nereistoxin analog insecticide developed by our country, which has contact killing, stomach poisoning and certain fumigation effects. Its mechanism of action is to block the transmission of insect nerve impulses and block the acetylcholine receptors, so that the insects lose their regulatory function, fall into paralysis, refuse to eat and die. It mainly controls rice stem borer, rice stem borer, rice leaf roller, thrips, leafhopper and other pests. It is rarely used in most other crops. The application range and insecticidal spectrum are narrow, and the quick effect is poor.

Apple golden moth (Lithocolletis ringoniella Matsumura) is an important leaf miner pest that has been rampant in northern apple production areas for many years. Diflubenzuron and hexaflumuron, etc. are the main control pesticides. Due to continuous use, the resistance of pests has been increasing. As a result, the control effect of these pesticides has been declining in recent years, and some areas have even been ineffective. Therefore, the prevention and control of leaf miner pests such as the golden leaf moth is faced with the current situation that no specific medicament is available. After years of research, the inventors of the present application have found that abamectin and dimehypo both exhibit insecticidal activity against the golden moth. The two agents have a unique mechanism of action and no cross-resistance. The point of action of pests greatly improves the insecticidal activity, thereby producing a synergistic effect, which is one of the effective ways to resist resistance and delay the development of resistance.

Microemulsion is a new type of high-efficiency and environmentally friendly dosage form. Using water as the substrate reduces the production cost of pesticides and reduces environmental pollution, which is of great significance to the development of green agriculture and the maintenance of ecological balance. The micelle particle size is smaller than the light wavelength, the particle fineness is small, and the additive content is high. Therefore, the spreading, penetration, wetting, and film-forming effects of the drug solution are superior to emulsifiable concentrates and suspension concentrates, and the effective utilization rate and drug effect are higher. The same dose of emulsifiable concentrate, suspending agent and powder can be increased by more than 20%. At present, most abamectin products at home and abroad are mostly in the form of emulsifiable concentrates, which seriously pollute the environment. The environmental protection department has launched monitoring on such pesticide products containing harmful aromatic solvents.

3. Contents of the invention

The purpose of the present invention is to aim at the deficiencies that Abamectin and Dimehypo are used separately, comprehensively absorb the advantages of the two and improve it, and provide a combination of Abamectin and Dimehypo insecticides with synergistic effect The preparation method of the substance and the microemulsion thereof is mainly used for preventing and controlling difficult pests such as apple goldenrod moth, and has good control effects on other Lepidoptera, Diptera, Homoptera and harmful mites.

The technical solution adopted in the present invention is:

Abamectin · dimehypo insecticide composition, the active ingredients include abamectin and dimehypo, and the weight percentage ratio of the raw materials for the preparation of the composition is 0.1% to 5% of abamectin and 10% to 10% of dimehypo 50%, the balance of additives.

The dosage form of the abamectin·dimehypo insecticide composition adopts microemulsion, and replaces a large amount of flammable benzene organic solvents with water, reduces product toxicity and production costs, and improves the safety of production and storage;

Improve the spreading, wetting, penetration, and film-forming properties of chemicals by adding surfactants and synergists, and improve the effective utilization of pesticides. It also includes, according to the proportion of raw materials by weight, 5-25% of emulsifier, 1-15% of co-solvent, 1-10% of synergist, 1-10% of stabilizer and the balance of water.

Suitable emulsifiers in the present invention are selected from the series of alkylphenol polyoxyethylene ethers, tristyrylphenol polyoxypropylene polyoxyethylene block polymers, castor oil polyoxyethylene ether series, styreneethylphenol polyoxyethylene ethers One or more compounds of formaldehyde polymer, cumylphenol polyoxyethylene ether, and dodecylbenzenesulfonate.

The suitable co-solvent of the present invention is selected from methanol, n-butanol, acetone, cyclohexanone, DMF, nitrogen methyl pyrrolidone or any one or a combination of two or more substances with similar characteristics or properties.

The suitable synergist of the present invention is selected from synergistic ether, synergistic phosphorus, octachlorodipropyl ether, azone, thione, fatty alcohol polyoxyethylene ether, ethyl sorbate, trimethylsiloxane or similar A combination of one or more than two surface-active substances of characteristic or performance.

The suitable stabilizer of the present invention is selected from any one or a combination of two or more of ethylene glycol, polyethylene glycol, glycerin, benzoate, xanthan gum or substances with similar properties or performances.

Suitable water in the present invention is selected from any one of tap water, ground water, deionized water, and distilled water.

The preparation method of insecticide composition microemulsion is:

1. Weigh abamectin, dimehypo and additive raw materials according to the above ratio;

2. Dissolve the abamectin ointment in the solubilizer first, add emulsifier, add or not add synergist, add or not add stabilizer, then add dimehypo water, and stir evenly;

3. Slowly make up the remaining amount of water, fully stir until it becomes a homogeneous transparent liquid, and then obtain the abamectin · insecticide microemulsion.

The present invention adopts abamectin and dimehypo for compounding, which has obvious synergistic effect, simultaneously broadens the scope of use, expands the insecticidal spectrum, and the two have no cross-resistance, and can effectively delay the resistance of pests (mites) It is mainly used to prevent and control various types of insect (mite) damage that occurs on various crops, especially for difficult pests such as apple golden moth that are currently difficult to control, showing extremely strong insecticidal activity, which is different from existing other pesticides.

The combined insecticidal microemulsion has a wide application range, can be used on most crops, has good safety, low cost and remarkable control effect. Tests prove that the preparation of the invention has stable chemical properties, remarkable complementary and synergistic effects, and exhibits synergistic effects on target pests. The method of use is spraying with water, and the concentration of the drug varies with the crops and the control objects, generally 200-800 μg/ml.

The advantages of the insecticide composition and its microemulsion form:

1. The combined use of two active ingredients can expand the prevention and control objects, and the application scope and insecticidal spectrum are obviously expanded. All have good control effects, especially remarkable control effects on the apple golden moth, which fills the gap that there is no high-efficiency agent for the control of this type of pests. It overcomes the shortcoming of poor quick-acting single dose. For example, the 1-day control effect on rice stem borer is 70% for a single dose of dimehytap, but 85% for a mixed dose, and the duration of action is about 5 days longer than that of dimehypo . In addition, the two agents have no cross-resistance, and individual pests that develop resistance to a single agent are sensitive to the composition, and the mode and site of action are significantly increased compared with the single agent, thereby delaying the generation of pest (mite) resistance.

2. Significant synergistic effect. Abamectin and dimehypo alone are 1.52 μg/ml and 1.14 μg/ml respectively for the toxicity EC ₅₀ to the larvae of the golden leaf moth. 10-50% combined use EC ₅₀ is less than 1.0μg/ml, co-toxicity coefficient CTC is greater than 154 (mixed pesticide bioassay national standard NY/T1154.7-2006 regulations, CTC ≥ 120 means synergistic effect; CTC ≤ 80 shows antagonistic effect; 80<CTC<120 shows additive effect), and the mixed synergistic effect is remarkable. Preliminary field experiments have proved that the control effect of 20% abamectin · dimehypo microemulsion on rice stem borer 15 days after treatment is about 30% higher than that of 20% dimehypo water, and 1.8% abamectin EC against The efficiency is increased by 35%, and the synergy is obvious.

3. The use of microemulsion formulations greatly reduces the use of organic solvents, reducing production costs and environmental pollution. The product is non-flammable, non-explosive, and safe for production, storage and transportation. After the medicine is mixed with water, the particle size of the active ingredient is only less than 1/100 times that of the EC preparation, and the penetration ability to the target insects is extremely strong; the wetting ability of the medicine solution is 20-30 times higher than that of the EC, and the medicine solution has good spreadability. The effective utilization rate is high; the drug effect is obviously better than that of emulsifiable concentrate and suspension preparation. Because it uses water as the base, it reduces the damage of the organic solvent in the emulsifiable concentrate preparation to young fruits and young leaves, and improves the safety of use; it has no peculiar smell when spraying, and reduces the harm to users.

4. Specific implementation

The present invention will be described in more detail below in conjunction with the examples, but the examples do not limit the present invention, and the percentages in the examples are all mass percentages.

Embodiment 1 20% abamectin · insecticide double microemulsion

Abamectin 0.1%

Insecticide 19.9%

Cyclohexanone 5%

DMP 5%

BRT-11 15%

Add water to 100%

Preparation method: After dissolving the original drug of abamectin with cyclohexanone, add DMF, stir evenly, add dimehypo aqueous solution to the standard content of 19.8%, then add BRT-11 emulsifier, stir evenly, slowly add the remaining water , stir well until homogeneous transparent liquid.

Embodiment 2 12% abamectin · insecticide double microemulsion

Abamectin 2%

Dimehypo 10%

Cyclohexanone 5%

DMF 5%

BRT-11 15%

601 emulsifier 2%

Add water to 100%

Preparation method: After dissolving the original drug of abamectin with cyclohexanone, add DMF, stir evenly, add dimehypo water solution to the standard content of 20%, add BRT-11 and 601 emulsifier, stir evenly, slowly add the remainder water, stir well until homogeneous and transparent liquid.

Embodiment 3 30% abamectin · insecticide double microemulsion

Abamectin 5%

Dimehypo 25%

Isopropanol 8%

DMF 5%

BRT-11 15%

Farm Milk 500 5%

Add water to 100%

Embodiment 4 41% abamectin · insecticide double microemulsion

Abamectin 1%

Dimehypo 40%

Cyclohexanone 8%

n-Butanol 5%

BRT-11 15%

601 emulsifier 5%

Add water to 100%

Embodiment 5 45% abamectin · insecticide double microemulsion

Abamectin 5%

Dimehypo 40%

Cyclohexanone 1%

n-Butanol 10%

BRT-11 15%

601 emulsifier 5%

Add water to 100%

Embodiment 6 55% abamectin · insecticide double microemulsion

Abamectin 5%

Dimehypo 50%

Cyclohexanone 10%

n-Butanol 1%

BRT-11 15%

601 emulsifier 10%

Add water to 100%

Embodiment 7 33% abamectin · insecticide double microemulsion

Abamectin 3%

Dimehypo 33%

Cyclohexanone 10%

n-Butanol 8%

BRT-11 15%

601 emulsifier 5%

Add water to 100%

The preparation method of embodiment 3-7 is identical with embodiment 1,2.

The physical and chemical properties of the prepared microemulsion are as follows:

Appearance: light yellow homogeneous transparent liquid

Transparent temperature range: -5～60℃

Stability over time: Stable for 2 years when stored at room temperature

Low temperature stability: -10～0℃ for two weeks without delamination, no precipitation, no turbidity

Emulsion stability: qualified (200 times liquid)

The above embodiments use abamectin and dimehypo to compound, which has obvious synergistic effect, and simultaneously broadens the scope of use, expands the insecticidal spectrum, and the two have no cross-resistance, which can effectively delay pest (mite) resistance. The production of medicinal properties is mainly used to prevent and control various types of insect (mite) damage on various crops, showing extremely strong insecticidal activity, which is different from other existing pesticides and insecticides.

The combined insecticidal microemulsion has a wide application range, can be used on most crops, has good safety, low cost and remarkable control effect. Tests prove that the preparation of the invention has stable chemical properties, remarkable complementary and synergistic effects, and exhibits synergistic effects on target pests. The method of use is spraying with water, and the concentration of the drug varies with the crops and the control objects, generally 200-800 μg/ml.

Claims (10)

1. Abamectin · dimehypo insecticide composition is characterized in that the active ingredients include abamectin and dimehypo, and the weight percentage ratio of raw materials for preparation of the composition is 0.1-5% of abamectin, dimehypo Zongbi 10-50%, the balance of additives. 2. The microemulsion of abamectin·sultap insecticide composition according to claim 1, characterized in that, according to the percentage distribution ratio of raw materials, it includes 0.1% to 5% of abamectin, 10% to 10% of sultap 50%, emulsifier 5-25%, co-solvent 1-15%, synergist 1-10%, stabilizer 1-10%, and the balance water. 3. The microemulsion of abamectin·dimehypo insecticide composition according to claim 2, characterized in that the emulsifier is selected from the series of alkylphenol polyoxyethylene ethers, tristyrylphenol polyoxypropylene Polyoxyethylene block polymer, castor oil polyoxyethylene ether series, styrene ethylphenol polyoxyethylene ether formaldehyde polymer, cumylphenol polyoxyethylene ether, one of dodecylbenzenesulfonate or a combination of two or more. 4. The microemulsion of abamectin·dimehypo insecticide composition according to claim 2, characterized in that the cosolvent is selected from the group consisting of methanol, ethanol, n-butanol, acetone, cyclohexanone, DMF, nitrogen methyl Any one or a combination of two or more of base pyrrolidones or substances with similar characteristics or properties. 5. The microemulsion of abamectin·dimehypo insecticide composition according to claim 2, characterized in that the synergist is selected from the group consisting of butyronyl ether, synergistic phosphorus, octachlorodipropyl ether, azone, Thione, fatty alcohol polyoxyethylene ether, ethyl sorbate, trimethylsiloxane or a combination of one or more surface active substances with similar characteristics or properties. 6. The microemulsion of abamectin·dimehypo insecticide composition according to claim 2, characterized in that the stabilizer is selected from the group consisting of ethylene glycol, polyethylene glycol, glycerol, benzoate, Any one or a combination of two or more of xanthan gum or substances with similar characteristics or properties. 7. The microemulsion of abamectin·dimehypo insecticide composition according to claim 2, characterized in that the suitable water is selected from any one of tap water, ground water, deionized water, and distilled water. 8. The method for preparing the microemulsion of the avermectin·sultap insecticide composition according to any one of claims 2-7, characterized in that: (1), weigh Abamectin, dimehypo and additive raw materials according to the above-mentioned proportioning; (2), first dissolve the abamectin in the cosolvent, add emulsifier, add or not add synergist, add or not add stabilizer, then add dimehydra water, stir evenly; (3) Slowly make up the remaining amount of water, and fully stir until it becomes a homogeneous transparent liquid to obtain the abamectin·sultap microemulsion. 9. The application of the microemulsion of the abamectin·sultap insecticide composition according to any one of claims 2-7, characterized in that it is used in the prevention and treatment of various crop pests in fruit trees, vegetables, wheat, and rice (mite) application. 10. The application of the microemulsion of the abamectin·sultap insecticide composition according to any one of claims 2-7, characterized in that it is applied to apple leafminer pests.