CN101288409A - Fipronil, chlopyrifos and production method thereof - Google Patents
Fipronil, chlopyrifos and production method thereof Download PDFInfo
- Publication number
- CN101288409A CN101288409A CNA2007100143471A CN200710014347A CN101288409A CN 101288409 A CN101288409 A CN 101288409A CN A2007100143471 A CNA2007100143471 A CN A2007100143471A CN 200710014347 A CN200710014347 A CN 200710014347A CN 101288409 A CN101288409 A CN 101288409A
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- CN
- China
- Prior art keywords
- worm nitrile
- fluorine worm
- add
- chlorpyrifos
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- 239000005899 Fipronil Substances 0.000 title abstract description 6
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N Fipronil Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 title abstract description 6
- 229940013764 fipronil Drugs 0.000 title abstract description 6
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 27
- SBPBAQFWLVIOKP-UHFFFAOYSA-N Chlorpyrifos Chemical compound CCOP(=S)(OCC)OC1=NC(Cl)=C(Cl)C=C1Cl SBPBAQFWLVIOKP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000005944 Chlorpyrifos Substances 0.000 claims abstract description 18
- 229910052731 fluorine Inorganic materials 0.000 claims description 26
- 239000011737 fluorine Substances 0.000 claims description 26
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 26
- 150000002825 nitriles Chemical class 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 16
- 239000003995 emulsifying agent Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- 239000006184 cosolvent Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethylsulphoxide Chemical group CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 4
- -1 polyoxyethylene Polymers 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- LNJXZKBHJZAIKQ-UHFFFAOYSA-N 1,1,1,2-tetrachloro-3-(2,3,3,3-tetrachloropropoxy)propane Chemical compound ClC(Cl)(Cl)C(Cl)COCC(Cl)C(Cl)(Cl)Cl LNJXZKBHJZAIKQ-UHFFFAOYSA-N 0.000 claims description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 2
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 claims description 2
- FIPWRIJSWJWJAI-UHFFFAOYSA-N Butyl carbitol 6-propylpiperonyl ether Chemical compound C1=C(CCC)C(COCCOCCOCCCC)=CC2=C1OCO2 FIPWRIJSWJWJAI-UHFFFAOYSA-N 0.000 claims description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N Cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 2
- 229940051841 POLYOXYETHYLENE ETHER Drugs 0.000 claims description 2
- 229960005235 Piperonyl Butoxide Drugs 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000003849 aromatic solvent Substances 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 claims description 2
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N o-xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 150000004072 triols Chemical class 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 17
- 241000238631 Hexapoda Species 0.000 abstract description 9
- 230000000749 insecticidal Effects 0.000 abstract description 8
- 235000013399 edible fruits Nutrition 0.000 abstract description 5
- 239000002917 insecticide Substances 0.000 abstract description 5
- 229920000742 Cotton Polymers 0.000 abstract description 4
- 240000006962 Gossypium hirsutum Species 0.000 abstract description 4
- 240000008962 Nicotiana tabacum Species 0.000 abstract description 4
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract description 4
- 240000007594 Oryza sativa Species 0.000 abstract description 4
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract description 4
- 239000002131 composite material Substances 0.000 abstract description 4
- 235000005822 corn Nutrition 0.000 abstract description 4
- 235000005824 corn Nutrition 0.000 abstract description 4
- 235000009566 rice Nutrition 0.000 abstract description 4
- 235000013311 vegetables Nutrition 0.000 abstract description 4
- 230000000266 injurious Effects 0.000 abstract 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 206010020649 Hyperkeratosis Diseases 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
- 239000000575 pesticide Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 230000003449 preventive Effects 0.000 description 4
- 235000014347 soups Nutrition 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 241000209149 Zea Species 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 241000254173 Coleoptera Species 0.000 description 2
- 241000255777 Lepidoptera Species 0.000 description 2
- 210000002784 Stomach Anatomy 0.000 description 2
- 241001414989 Thysanoptera Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000008041 oiling agent Substances 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- VQGHOUODWALEFC-UHFFFAOYSA-N 2-Phenylpyridine Chemical compound C1=CC=CC=C1C1=CC=CC=N1 VQGHOUODWALEFC-UHFFFAOYSA-N 0.000 description 1
- 241000665051 Chilo sacchariphagus indicus Species 0.000 description 1
- 241000917171 Eriosomatinae Species 0.000 description 1
- 240000007119 Malus pumila Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- GTCAXTIRRLKXRU-UHFFFAOYSA-N Methyl carbamate Chemical class COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- ZOURZULAXSMKGW-UHFFFAOYSA-N benzene;pyridine-3-carbonitrile Chemical compound C1=CC=CC=C1.N#CC1=CC=CN=C1 ZOURZULAXSMKGW-UHFFFAOYSA-N 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000002045 lasting Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000593 microemulsion method Methods 0.000 description 1
- 230000003287 optical Effects 0.000 description 1
- 239000003986 organophosphate insecticide Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000003019 stabilising Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Abstract
The invention relates to the technical field of new dosage form of microemulsion for fipronil and chlorpyrifos composite mixed insecticide, in particular to the fipronil and the chlorpyrifos mixed microemulsion and a production method thereof. The invention aims at providing a composite mixed microemulsion preparation with the fipronil and the chlorpyrifos serving as effective components and a preparation method thereof. The microemulsion preparation of the invention synthesizes and mixes the insecticides of the fipronil and the chlorpyrifos has the advantages that the readily availability and durable effectiveness are enhanced, and the drug resistance that is generated by the continuous use of a single dose to the injurious insects is weakened. The composite mixed microemulsion preparation can be used for comprehensive control of the injurious insects to a plurality of crops such as paddy rice, fruit trees, corns, cottons, tobacco, vegetables, etc.
Description
Technical field:
Fluorine worm nitrile, chlorpyrifos mixture insecticide and the microemulsion novel form that the present invention relates to, detailed say so fluorine worm nitrile, chlorpyrifos mixture microemulsion and production method thereof.
Background technology:
Fluorine worm nitrile is wide spectrum, the efficient pesticides of at first being developed by French Rhone-Poulenc, chemical name is: (R, S)-5-amino-1-(2,6-dichloromethyl phenyl)-4-trifluoromethanesulpacidc acidc benzene pyridine-3-nitrile, general (Fipronil) by name, commodity are called Regent (sharp strength spy), are a kind of phenylpyridine insecticides.The product of external registration has: 5% suspending agent, 0.3% granule, 5% seed dressing, 80% water dispersion granule, fluorine worm nitrile preparation have tag, stomach toxicity and systemic action, insecticidal spectrum is wide, can be widely used in the control of insect of various crop such as paddy rice, fruit tree, corn, cotton, tobacco, vegetables, Semiptera, Lepidoptera, coleoptera, thrips insect are had high preventive effect.And there is not cross resistance with conventional organophosphorous pesticide, pyrethrin pesticide, methyl carbamate class agricultural chemicals.But its quick-acting is relatively poor, and single agent uses continuously and be easy to generate resistance, to as shortcomings such as insect effects such as paddy stem borer are undesirable.
Chlopyrifos is wide spectrum, the efficient organophosphorus insecticide of at first being developed by LG-DOW, and chemical name is: zero, zero-diethyl-zero-3,5,6-two chloro-2-pyridine radicals phosphorothioates, its adopted name is: chlorpyrifos, commodity are called Le Siben.External registration has 48.8% missible oil (weight/capacity), chlopyrifos have tag, stomach toxicity and stronger infiltration and fumigation action, insecticidal spectrum is wide, also can be widely used in the control of insect of various crop such as paddy rice, fruit tree, corn, cotton, tobacco, vegetables, Semiptera, Lepidoptera, coleoptera, thrips insect are had high preventive effect.Though drug effect speed is fast, uses continuously and produced resistance for many years.
With above two kinds of pesticide compositionals, both improved quick-acting, increase lasting effect again, alleviated insect is used generation continuously to single agent pesticide resistance simultaneously.Can be used as the integrated control of various crop insects such as paddy rice, fruit tree, corn, cotton, tobacco, vegetables.
Microemulsion is to be matrix with water, and by former medicine dissolving, the microemulsified process forms the stabilising system of even phase.Micella particle diameter in the system is less than optical wavelength, grain fineness is little, because of its auxiliary agent content height, the opening up of its soup, infiltration, wetting, filming function all has and cream preparation and suspending agent, the effective rate of utilization height of its soup, drug effect be missible oil and suspending agent under the same dose 1.2-1.5 doubly.Microemulsion is matrix with water, has also reduced the production cost of agricultural chemicals, helps alleviating the pressure of environmental pollution, to the development green agriculture, keeps ecology and is of great importance.
Summary of the invention:
The purpose of this invention is to provide a kind of is the preparation and preparation method thereof of the complex microemulsion of active ingredient with fluorine worm nitrile, chlopyrifos.
The main technical schemes that the present invention adopts is: replace a large amount of inflammable benzene class organic solvents with water, reduce product toxicity and production cost; Improve the safety of producing and storing and transporting; Make two kinds of mutual synergy of insecticide by prescription screening, by surfactant and add synergist and improve the opening up of medicament, wetting, infiltration, film forming, improve the availability of agricultural chemicals, reduce actual dosage.
Fluorine worm nitrile of the present invention, chlorpyrifos micro emulsion, wherein fluorine worm nitrile, chlopyrifos are main component, mass content in preparation is respectively 1-10% and 20-50%, and other compositions comprise that emulsifier 5-25%, cosolvent 1-15%, synergist 1-10%, stabilizing agent 1-10%, surplus are water.
The emulsifier that the present invention is fit to is one or more the compound that is selected from alkylphenol polyoxyethylene series, agricultural emulsifier NO series, castor oil polyoxyethylene ether series, phenethyl phenol polyethenoxy ether yuban, the dodecyl benzene sulfonate.(newborn BRT-1 emulsifier)
The cosolvent that the present invention is fit to is to be selected from aromatic solvent as toluene, dimethylbenzene etc.; C1-5-unit alcohol as: methyl alcohol, ethanol, n-butanol etc.; Acetone, cyclohexanone, dimethyl sulfoxide (DMSO) or have similar features or the material of performance in any one or two kinds of above compositions.
The synergist that the present invention is fit to be selected from Butacide, synergy phosphorus, Octachlorodipropyl Ether, azone, thiophene ketone, fast T, fatty alcohol-polyoxyethylene ether have similar features or the surface reactive material of performance in one or more composition.
The stabilizing agent that the present invention is fit to be selected from ethylene glycol, polyethylene glycol, glycerine, urea have similar characteristic or the material of performance in any one or two kinds of above compositions.
The water that the present invention is fit to is to be selected from running water, underground water, deionized water, the distilled water any one.
This microemulsion can be with known preparation method preparation, and chlopyrifos, fluorine worm nitrile are dissolved in the middle of the flux, adds emulsifier, add or do not add synergist, add or do not add stabilizing agent, stir, slowly add excess water, be stirred well to even phase transparency liquid, both got fluorine worm nitrile, chlorpyrifos micro emulsion.The method that this microemulsion uses is spraying, and working concentration regards thing as and controlling object uses 100-500ppm usually.Below in conjunction with embodiment the present invention is made more specific description, but embodiment does not limit the present invention, the percentage among the embodiment is mass percent.
Embodiment 1
12% fluorine worm nitrile, chlorpyrifos micro emulsion
Fluorine worm nitrile 2%
Chlopyrifos 10%
Toluene 5%
DMF 5％
BRT-1 15％
Water adds to 100%
Preparation method: after fluorine worm nitrile, the former medicinal toluene of chlopyrifos and DMF dissolving, add the BRT-1 emulsifier, stir, slowly add excess water, be stirred well to even phase transparency liquid.
Embodiment 2
22% fluorine worm nitrile, chlorpyrifos micro emulsion
Fluorine worm nitrile 2%
Chlopyrifos 20%
Toluene 15%
DMF 5％
BRT-1 18％
Water adds to 100%
Preparation method: after fluorine worm nitrile, the former medicinal toluene of chlopyrifos and DMF dissolving, add the BRT-1 emulsifier, stir, slowly add excess water, be stirred well to even phase transparency liquid.
Embodiment 3
45% fluorine worm nitrile, chlorpyrifos micro emulsion
Fluorine worm nitrile 5%
Chlopyrifos 40%
Toluene 5%
DMF 15％
N-butanol 5%
BRT-1 18％
Water adds to 100%
Preparation method: after fluorine worm nitrile, the former medicinal toluene of chlopyrifos, DMF and n-butanol dissolving, add the BRT-1 emulsifier, stir, slowly add excess water, be stirred well to even phase transparency liquid.
The microemulsion physicochemical property of preparation is as follows:
Outward appearance: light yellow or pale brown look is spared the phase transparency liquid
Transparency temperature zone :-5-60 ℃
Ageing stability: seasoning was stablized in 2 years under the normal temperature
Low-temperature stability :-10-0 ℃ of two weeks are not stratified, do not separate out, and are haze-free
Stability of emulsion: qualified (200 times of liquid)
Microemulsion of the present invention has the following advantages with missible oil and suspending agent ratio:
1, a large amount of minimizing organic solvent has reduced production cost and to the pollution of environment, product is not Inflammable, non-explosive, produce storing safety.
2, active ingredient size ratio cream preparation was little more than 100 times after medicament was converted water, to wearing of target Ability is stronger thoroughly; The wettability of soup improves 20-30 doubly than missible oil, the plate-out ability of soup is good, Effective rate of utilization height, drug effect are better than missible oil and suspension formulation. Through field test, 30% chlopyrifos micro emulsion Agent, 40% chlorpyrifos ec are done the test of pesticide effectiveness to 1500 times of apple tree woolly aphids, and behind the medicine 15 days, preventive effect Quite, illustrate that preventive effect is still suitable in the situation of active constituent content than missible oil low 25%.
3, product composite after, slowed down to a great extent the resistance to the action of a drug of insect, improved insecticidal spectrum, More be conducive to the integrated control of insect.
4, micro emulsion is take water as matrix, alleviated in the cream preparation organic solvent to the wound of young fruit and tender leaf Evil has improved safety in utilization.
Claims (6)
1, a kind of fluorine worm nitrile, its feature of chlorpyrifos micro emulsion comprise following composition and content (by mass)
Fluorine worm nitrile 1-10%
Chlopyrifos 20-50%
Emulsifier 5-25%
Cosolvent 0-15%
Synergist 0-10%
Stabilizing agent 0-10%
Excess water
2, a kind of microemulsion according to claim 1, it is characterized in that described emulsifier is selected from one or more the compound in alkylphenol polyoxyethylene series, agricultural emulsifier NO series, castor oil polyoxyethylene ether series, phenethyl phenol polyethenoxy ether yuban, the dodecyl benzene sulfonate.(newborn BRT-1 emulsifier)
3, microemulsion according to claim 1 is characterized in that, described cosolvent is selected from aromatic solvent as toluene, dimethylbenzene etc.; The C1-5 monohydric alcohol is as methyl alcohol, ethanol, n-butanol etc.; Acetone, cyclohexanone, any one or two kinds of above compositions of dimethyl sulfoxide (DMSO).
4, fluorine worm nitrile according to claim 1, chlorpyrifos micro emulsion, it is characterized in that described synergist is selected from one or more the composition in Butacide, synergy phosphorus, Octachlorodipropyl Ether, azone, thiophene ketone, fast T, organic silicon surfactant, the fatty alcohol-polyoxyethylene ether active substance.
5, fluorine worm nitrile according to claim 1, chlorpyrifos micro emulsion is characterized in that, described stabilizing agent is selected from ethylene glycol, polyethylene glycol, interior triol, any one or two kinds of above compositions.
6, a kind of fluorine worm nitrile, chlorpyrifos micro emulsion production method, it is characterized in that, chlopyrifos and fluorine worm nitrile are dissolved in the middle of the cosolvent, add emulsifier, add or do not add synergist, add or do not add stabilizing agent, stir, slowly add excess water, be stirred well to even phase transparency liquid, both got fluorine worm nitrile, chlorpyrifos micro emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100143471A CN101288409A (en) | 2007-04-21 | 2007-04-21 | Fipronil, chlopyrifos and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100143471A CN101288409A (en) | 2007-04-21 | 2007-04-21 | Fipronil, chlopyrifos and production method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101288409A true CN101288409A (en) | 2008-10-22 |
Family
ID=40032997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100143471A Pending CN101288409A (en) | 2007-04-21 | 2007-04-21 | Fipronil, chlopyrifos and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101288409A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2464449A (en) * | 2008-09-05 | 2010-04-21 | Norbrook Lab Ltd | A topical ectoparasiticide composition |
| US8404735B2 (en) | 2009-03-18 | 2013-03-26 | Omnipharm Limited | Parasiticidal formulation |
| CN103271082A (en) * | 2013-06-19 | 2013-09-04 | 北京燕化永乐农药有限公司 | Insect killing composition |
| CN107751238A (en) * | 2017-11-17 | 2018-03-06 | 青海省农林科学院 | One kind preventing and treating rape flea beetle, stem weevil seed coat agent |
| CN108208015A (en) * | 2018-02-08 | 2018-06-29 | 武汉楚强生物科技有限公司 | A kind of agricultural chemicals suspension agent and its preparation method and application |
-
2007
- 2007-04-21 CN CNA2007100143471A patent/CN101288409A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2464449A (en) * | 2008-09-05 | 2010-04-21 | Norbrook Lab Ltd | A topical ectoparasiticide composition |
| GB2464449B (en) * | 2008-09-05 | 2011-10-12 | Norbrook Lab Ltd | A topical ectoparasticide composition |
| US8404735B2 (en) | 2009-03-18 | 2013-03-26 | Omnipharm Limited | Parasiticidal formulation |
| US8580837B2 (en) | 2009-03-18 | 2013-11-12 | Fidopharm, Inc. | Parasiticidal formulation |
| US8829038B2 (en) | 2009-03-18 | 2014-09-09 | Velcera, Inc. | Parasiticidal formulation |
| CN103271082A (en) * | 2013-06-19 | 2013-09-04 | 北京燕化永乐农药有限公司 | Insect killing composition |
| CN107751238A (en) * | 2017-11-17 | 2018-03-06 | 青海省农林科学院 | One kind preventing and treating rape flea beetle, stem weevil seed coat agent |
| CN108208015A (en) * | 2018-02-08 | 2018-06-29 | 武汉楚强生物科技有限公司 | A kind of agricultural chemicals suspension agent and its preparation method and application |
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