CN1234348C - Plant hard hollow capsule and its preparng method - Google Patents
Plant hard hollow capsule and its preparng method Download PDFInfo
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- CN1234348C CN1234348C CN 200410012944 CN200410012944A CN1234348C CN 1234348 C CN1234348 C CN 1234348C CN 200410012944 CN200410012944 CN 200410012944 CN 200410012944 A CN200410012944 A CN 200410012944A CN 1234348 C CN1234348 C CN 1234348C
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- glucomannoglycan
- soybean protein
- protein isolate
- hard capsule
- konjaku
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Abstract
The present invention discloses a plant hard hollow capsule and a preparing method thereof. The hard capsule is composed of modified konjak glucomannan as a plant raw material, soy isolation protein, a coagulation system and water. The preparing process comprises: konjak powder is gelatinized, modifying agents are added into the konjak powder, the mixture reacts for a certain time, and the reaction products are washed, dried and pulverized, so that modified products are obtained; soy isolation protein is gelatinized, and treated in a thermal denaturation mode; the pH value of the soy isolation protein is regulated; the modified products and cross-linking agents are added into the soy isolation protein to carry out copolymerization, and modified konjak glucomannan-soy isolation protein compounds are obtained; coagulating agents and coagulant aids are added to the compound sol, the mixture is uniformly stirred, a mould plate is dipped into the mixture and dried, and after the steps of pulling out a shell, cutting and fitting are carry out to the mould plate, a plant hard hollow capsule is prepared.
Description
Technical field
The present invention relates to the membrane complex that becomes of a kind of modified konjaku glucomannoglycan and soybean protein isolate copolymerization, preferred carboxy methyl konjaku glucomannoglycan-soybean protein isolate complex (CMKGM-SPI complex) is used for medicine, veterinary, food, cosmetics or other film like products.More specifically relate to a kind of plant hollow and hard capsule, also relate to the capsular preparation method of a kind of plant hollow and hard simultaneously.Be preferred for the predose preparation, as hard capsule preparation.Hollow and hard capsule by the present invention obtains is similar to gelatin hollow and hard capsule, and its performance is better than gelatin hollow and hard capsule.
Background technology
Most preferably gelatin is made in the capsular industry of traditional hollow and hard, and this is because it has the characteristic of aspects such as gelling, film forming and surface activity.Gelatin hollow and hard capsule to the production of capsule preparations, transport and store certain humiture requirement, be unsuitable for the hygroscopicity medicine, to the water sensitive medicine, contain production, storage and the transportation of aldehyde radical medicine, vegetarian and low cold, the regional capsule preparations of high temperature.The manufacture process of traditional hard gelatin capsule comprises: mold pin is immersed in the hot solution of gelatin, from gelatin solution, takes out the mould pin, allow the gelatin solution that sticks on the mould pin solidify by cooling, and dry and from the mould pin formation shell of backing off.On the viscosity of colloidal sol behind the colloidal sol, the dipping back mold pin solution to flow and solidify be the capsular committed step that obtains the thickness homogeneous.By retrieval, do not find that a kind of plant hollow and hard capsule that is raw material with Rhizoma amorphophalli and soybean protein isolate and preparation method thereof is disclosed or uses.
Summary of the invention
The object of the present invention is to provide a kind of plant hollow and hard capsule, this capsule can adapt to various different purposes.Modified konjaku glucomannoglycan such as carboxy methyl konjaku glucomannoglycan (CMKGM) have better flowability and filming performance than Rhizoma amorphophalli (KGM), with CMKGM and other polymer such as soybean protein isolate copolymerization under certain condition, they have mechanical performance, the gas barrier properties of the thin film of the good compatibility and product formation to improve a lot.Overcome gelatin hollow and hard capsule be unfavorable for storing, easily pollute, be unsuitable for easy hygroscopicity medicine and can not satietin trencherman requirement etc. defective.
Another object of the present invention is to provide a kind of preparation plant hollow and hard capsular method, and is easy to implement the method, easy to operate.
Technical scheme of the present invention is achieved in that plant hollow and hard capsule is characterized in that: described hollow and hard capsule is by vegetable raw material modified konjaku glucomannoglycan (carboxy methyl konjaku glucomannoglycan, the maleic anhydride esterification glucomannoglycan, acetic anhydride esterification glucomannoglycan, the oxidation glucomannoglycan), soybean protein isolate (SPI), coagulant, flocculation aid and water are formed, their weight percentages of components is: modified konjaku glucomannoglycan 31%～51%, soybean protein isolate 25.4%～47.8%, coagulant 8.8%～27.5%, flocculation aid 3.3%～7%, water 3.4%～9%.
One kind of plant hollow and hard capsule, it is made by following raw materials by weight percent:
Raw material weight percentage ratio
Carboxy methyl konjaku glucomannoglycan 33-49
Soybean protein isolate 26-46.5
Carrageenan 10.4-20.8
Potassium chloride 4-6
Water 4-7
One kind of plant hollow and hard capsule, it is made by following raw materials by weight percent:
Raw material weight percentage ratio
Oxidation glucomannoglycan 35-45
Soybean protein isolate 29-43.8
Virgin rubber 12-19.2
Potassium phosphate 4.5-5.5
Water 4.5-6.4
One kind of plant hollow and hard capsule, it is made by following raw materials by weight percent:
Raw material weight percentage ratio
Maleic anhydride esterification glucomannoglycan 35-42.8
Soybean protein isolate 27.8-42.6
Carrageenan 13.6-18.5
Potassium citrate 4.8-5.3
Water 5-6
One kind of plant hollow and hard capsule, it is made by following raw materials by weight percent:
Raw material weight percentage ratio
Acetic anhydride esterification glucomannoglycan 37-41.9
Soybean protein isolate 28.8-41.5
Carrageenan 14.8-16.7
Potassium chloride 5-5.2
Water 5.5-5.8
According to technical scheme of the present invention, described plant hollow and hard capsule makes like this:
The modification scheme of modified konjaku glucomannoglycan comprises acetic anhydride, maleic anhydride esterification modification, monoxone is etherification modified and the hydrogen peroxide oxidation modification, the preferred etherification modified product carboxy methyl konjaku of monoxone glucomannoglycan (CMKGM).
A, with Rhizoma amorphophalli powder gelatinizing under 40～70 ℃ of temperature, the mixed liquor of the monoxone of adding konjaku powder 80wt%-120wt% and the potassium iodide of 10wt%～30wt%, etherification reaction 3～4 hours, washing, dry, pulverize carboxy methyl konjaku glucomannoglycan (CMKGM).
B, with soybean protein isolate dispersed with stirring under 30～60 ℃ of temperature, the soybean protein solid content is 1%～8%, 80～100 ℃ of heat treatments 25～35 minutes, transferring pH value is 9～10.
C, the CMKGM that adds soybean protein isolate 65wt%～200wt% and the cross-linking agent (cross-linking agent is used in food industry such as sodium trimetaphosphate, phosphorus oxychloride always) of dry powder gross weight 0.01%～10%, copolyreaction is 2～5 hours under 40～70 ℃ of temperature, and washing, drying and crushing get modified konjaku glucomannoglycan-soybean protein isolate complex (CMKGM-SPI).
D, under 60～80 ℃ of temperature with CMKGM-SPI complex colloidal sol, add coagulation system (hydrocolloid and cation), stir, after the insulation degassing, pour feed liquid into immersion trough, dip in glue, promptly can be made into plant hollow and hard capsule after drying, pull out shell, cutting and arrangement through template again.
Coagulant is made up of the mixture of hydrocolloid or hydrocolloid, wherein is fit to produce the hydrocolloid with synergisticing performance and can be selected from natural zostera marina, natural seed natural gum, natural plants exudate, natural rubber polymer etc.Preferred polysaccharide glue is as K type carrageenan, xanthan gum.Wherein flocculation aid is for providing cation (Ca
2+, K
+) salt such as potassium chloride, potassium citrate, potassium phosphate, calcium chloride etc.
Plant hollow and hard capsule of the present invention can be used for producing the container that unit dosage form is provided, and for example is used for agricultural chemicals, seed, food, medicine, spice, cosmetics etc.; Water content is low, is fit to filling hygroscopicity medicine, is beneficial to the stability of medicine in storage and transport process, and stability of drug products is good; Need not constant temperature and humidity stores; All be plant material, can not propagate foot and mouth disease and bovine spongiform encephalopathy etc., be difficult for polluting satietin diet culture person requirement; Be suitable for containing the storage and the transportation of aldehyde radical medicine.
The specific embodiment
Embodiment 1
Raw material weight percentage ratio
Carboxy methyl konjaku glucomannoglycan 42.6%
Soybean protein isolate 28.4%
Carrageenan 17.7%
Potassium chloride 3.3%
Water 8%
1,24 gram soybean protein isolates are dissolved in the 1100mL aqueous dispersion, 90 ℃ of heat treatments 35 minutes, and the sodium hydroxide of 0.1N is transferred the PH to 10 of solution, adds 36 gram 40 purpose CMKGM and 3mL phosphorus oxychloride, copolyreaction 3 hours.Precipitation, the dry CMKGM-SPI complex that gets of washing.
2, be that 40 purpose CMKGM-SPI complex 32 gram is under agitation mixed with 568mL water with granularity, continue dispersed with stirring, 55～60 ℃ of abundant swellings 40～60 minutes.Make it to form uniform sol
3, take by weighing carrageenan 8 gram, pour in the 392mL water and stir evenly, be heated to more than 60 ℃ dissolving evenly, fully swelling is 30～40 minutes, makes it to form uniform sol.
4, will more than the CMKGM-SPI complex colloidal sol that makes and the weight ratio abundant mixing of carrageenan colloidal sol by 1.5: 1, and interpolation accounts for 0.15% flocculation aid potassium chloride of glue gross weight, stirs evenly.
5, insulation is 0.5 hour, and mixed sols is cooled to 50 ℃, leaves standstill the degassing, and the hard capsule mould was slowly immersed feed liquid about 8 seconds, slowly proposes again, 35 ℃～40 ℃ dryings, pulls out shell, cutting, and arrangement promptly gets the hollow and hard capsule.
Embodiment 2
Raw material weight percentage ratio
Oxidation glucomannoglycan 50.8%
Soybean protein isolate 25.4%
Xanthan gum 12.0%
Potassium phosphate 3.8%
Water 8%
1,30 gram soybean protein isolates are dissolved in the 1000mL aqueous dispersion, 100 ℃ of heat treatments 30 minutes, and the sodium hydroxide of 0.1N is transferred the PH to 9 of solution, adds 60 gram 40 purpose oxidation glucomannoglycan OKGM and 2.5 gram sodium trimetaphosphates, copolyreaction 2 hours.Precipitation, the dry OKGM-SPI complex that gets of washing.
2, be that 40 purpose OKGM-SPI complex 34.5 gram is under agitation mixed with 665.5mL water with granularity, continue dispersed with stirring, 60 ℃ of swellings 40 minutes.Make it to form uniform sol
3, take by weighing xanthan gum 5.43 gram, pour in the 294.5mL water and stir evenly, be heated to more than 70 ℃ dissolving evenly, fully swelling is 1 hour, makes it to form uniform sol.
4, will more than the OKGM-SPI complex colloidal sol that makes and the weight ratio abundant mixing of xanthan gum colloidal sol by 7: 3, and interpolation accounts for 0.16% flocculation aid potassium phosphate of glue gross weight, stirs evenly.
5, insulation is 0.5 hour, and mixed sols is cooled to 70 ℃, leaves standstill the degassing, and the hard capsule mould was slowly immersed feed liquid about 8 seconds, slowly proposes again, 35 ℃～40 ℃ dryings, pulls out shell, cutting, and arrangement promptly gets the hollow and hard capsule.
Embodiment 3
Raw material weight percentage ratio
Maleic anhydride esterification glucomannoglycan 32%
Soybean protein isolate 32%
Carrageenan 27.5%
Potassium citrate 5.1%
Water 3.4%
1,32 gram soybean protein isolates are dissolved in the 1000mL aqueous dispersion, 100 ℃ of heat treatments 30 minutes, and the sodium hydroxide of 0.1N is transferred the PH to 9 of solution, adds 32 gram 40 purpose maleic anhydride esterification glucomannoglycan and 1.5mL phosphorus oxychloride, copolyreaction 3 hours.Precipitation, the dry esterification Rhizoma amorphophalli glucomannan-soybean protein isolate complex that gets of washing.
2, be that 40 purpose esterification Rhizoma amorphophalli glucomannans-soybean protein isolate complex, 56 grams are under agitation mixed with 1144mL water with granularity, continue dispersed with stirring, 60 ℃ of swellings 50 minutes.Make it to form even colloidal sol.
3, take by weighing K type carrageenan 24 gram, pour in the 776mL water and stir evenly, be heated to more than 70 ℃ dissolving evenly, fully swelling is 1 hour, makes it to form even colloidal sol.
4, will more than the esterification Rhizoma amorphophalli glucomannan-soybean protein isolate complex colloidal sol that makes and the weight ratio abundant mixing of carrageenan colloidal sol by 1.5: 1.0, and interpolation accounts for 0.22% flocculation aid potassium citrate of glue gross weight, stirs evenly.
5, insulation is 0.5 hour, and mixed sols is cooled to 70 ℃, leaves standstill the degassing, and the hard capsule mould was slowly immersed feed liquid about 8 seconds, slowly proposes again, 35 ℃～40 ℃ dryings, pulls out shell, cutting, and arrangement promptly gets the hollow and hard capsule.
Embodiment 4
Raw material weight percentage ratio
Acetic anhydride esterification glucomannoglycan 31.8%
Soybean protein isolate 47.8%
Carrageenan 8.8%
Potassium chloride 6.6%
Water 5%
1,45 gram soybean protein isolates are dissolved in the 1100mL aqueous dispersion, 100 ℃ of heat treatments 30 minutes, and the sodium hydroxide of 0.1N is transferred the PH to 9 of solution, adds 30 gram 40 purpose CMKGM and 2mL phosphorus oxychloride, copolyreaction 4 hours.Precipitation, the dry CMKGM-SPI complex that gets of washing.
2, be that 40 purpose CMKGM-SPI complex 54 gram is under agitation mixed with 946mL water with granularity, continue dispersed with stirring, 60 ℃ of abundant swellings 60 minutes.Make it to form uniform sol.
3, take by weighing carrageenan 12 gram, pour in the 988mL water and stir evenly, heating makes dissolving evenly, and fully swelling makes it to form uniform sol.
4, will more than the CMKGM-SPI complex colloidal sol that makes and the weight ratio abundant mixing of carrageenan colloidal sol by 2: 1, and interpolation accounts for 0.38% flocculation aid potassium chloride of glue gross weight, stirs evenly.
5, insulation is 0.5 hour, and mixed sols is cooled to 70 ℃, leaves standstill the degassing, and the hard capsule mould was slowly immersed feed liquid about 8 seconds, slowly proposes again, 35 ℃～40 ℃ dryings, pulls out shell, cutting, and arrangement promptly gets the hollow and hard capsule.
Survey capsule sample overall dimensions, disintegration and friability (pressing Pharmacopoeia of the People's Republic of China version standard in 2000 hollow and hard capsule item detects), the result is as follows:
Sample disintegration (min) friability overall dimensions:
1 7.5 is qualified
2 6.3 is qualified
3 17.4 is qualified
4 16.2 is qualified
Claims (6)
1, a kind of plant hollow and hard capsule, it is made by following raw materials by weight: modified konjaku glucomannoglycan 31%～51%, soybean protein isolate 25.4%～47.8%, coagulant 8.8%～27.5%, flocculation aid 3.3%～7%, water 3.4%～9%; The modified konjaku glucomannoglycan is carboxy methyl konjaku glucomannoglycan, oxidation glucomannoglycan, maleic anhydride esterification glucomannoglycan, acetic anhydride esterification glucomannoglycan; Coagulant is carrageenan or xanthan gum; Flocculation aid is for providing cation Ca
2+, K
+Salt such as potassium chloride, potassium citrate, potassium phosphate, calcium chloride.
2, a kind of plant hollow and hard capsule according to claim 1 is characterized in that:
Raw material weight percentage ratio
Carboxy methyl konjaku glucomannoglycan 33-49
Soybean protein isolate 26-46.5
Carrageenan 10.4-20.8
Potassium chloride 4-6
Water 4-7.
3, a kind of plant hollow and hard capsule according to claim 1 is characterized in that:
Raw material weight percentage ratio
Oxidation glucomannoglycan 35-45
Soybean protein isolate 29-43.8
Xanthan gum 12-19.2
Potassium phosphate 4.5-5.5
Water 4.5-6.4.
4, a kind of plant hollow and hard capsule according to claim 1 is characterized in that:
Raw material weight percentage ratio
Maleic anhydride esterification glucomannoglycan 35-42.8
Soybean protein isolate 27.8-42.6
Carrageenan 13.6-18.5
Potassium citrate 4.8-5.3
Water 5-6.
5, a kind of plant hollow and hard capsule according to claim 1 is characterized in that:
Raw material weight percentage ratio
Acetic anhydride esterification glucomannoglycan 37-41.9
Soybean protein isolate 28.8-41.5
Carrageenan 14.8-16.7
Potassium chloride 5-5.2
Water 5.5-5.8.
6, the capsular preparation method of the described plant hollow and hard of a kind of realization claim 1, it may further comprise the steps:
A, with Rhizoma amorphophalli powder gelatinizing under 40～70 ℃ of temperature, add the modifier of konjaku powder 10wt%～120wt%, react 2～4 hours, wash, drying and crushing gets the modified konjaku glucomannoglycan;
B, with soybean protein isolate dispersed with stirring under 30～60 ℃ of temperature, the soybean protein isolate solid content is 1%～8%, 80～100 ℃ of heat treatments 25～35 minutes, transferring pH value is 9～10;
The modified product of the konjaku powder of C, adding soybean protein isolate 65wt%～200wt% and the cross-linking agent of dry powder gross weight 0.01%～10%, copolyreaction is 2～5 hours under 40～70 ℃ of temperature, washing, dry, pulverize modified konjaku glucomannoglycan-soybean protein isolate complex;
D, under 60～80 ℃ of temperature with CMKGM-SPI complex colloidal sol, add coagulation system, stir, after the insulation de-bubbled, pour feed liquid into immersion trough, dip in glue, promptly can be made into plant hollow and hard capsule after drying, pull out shell, cutting and arrangement through template again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012944 CN1234348C (en) | 2004-03-30 | 2004-03-30 | Plant hard hollow capsule and its preparng method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012944 CN1234348C (en) | 2004-03-30 | 2004-03-30 | Plant hard hollow capsule and its preparng method |
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|---|---|
| CN1561971A CN1561971A (en) | 2005-01-12 |
| CN1234348C true CN1234348C (en) | 2006-01-04 |
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|---|---|---|---|
| CN 200410012944 Expired - Fee Related CN1234348C (en) | 2004-03-30 | 2004-03-30 | Plant hard hollow capsule and its preparng method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100358510C (en) * | 2005-04-27 | 2008-01-02 | 中国科学院海洋研究所 | Preparation of floridean polysaccharide vegetable prandial fiber medicinal hard capsule |
| WO2006132398A1 (en) * | 2005-06-06 | 2006-12-14 | Ajinomoto Co., Inc. | Capsule coating composition |
| CN100375618C (en) * | 2005-08-02 | 2008-03-19 | 武汉工业学院 | High performance composite hollow konjaku capsule and its prepn process |
| CN101235238B (en) * | 2008-01-21 | 2010-04-14 | 福建农林大学 | Environmental protection dope and its preparation method |
| CN101596146B (en) * | 2008-06-06 | 2013-03-27 | 中国科学院海洋研究所 | Method for controlling temperature in the production process of seaweed polysaccharide plant empty capsules |
| CN101693020B (en) * | 2009-10-22 | 2011-04-20 | 华慧颖 | Enteric soluble medicine empty capsule prepared by replacing part of gelatin with defatted soybean meal extractive and preparation process |
| CN102696940A (en) * | 2012-03-16 | 2012-10-03 | 桑植县溇水大鲵生物科技有限公司 | Detox beauty capsule of giant salamander and production method thereof |
| CN105985450B (en) * | 2015-02-05 | 2019-06-07 | 北京化工大学 | A kind of modified konjaku polysaccharide and its preparation and application |
| CN105166887B (en) * | 2015-08-14 | 2018-04-20 | 湖北坤艳药业有限责任公司 | A kind of health care product auxiliary material and its application |
| CN108553444A (en) * | 2018-04-25 | 2018-09-21 | 常州市阿曼特医药科技有限公司 | A kind of health care Capsules and preparation method thereof |
| CN109953975A (en) * | 2019-02-28 | 2019-07-02 | 常州市顺旭商贸有限公司 | A kind of preparation method of slow-release polysaccharide-based Capsules |
| CN113876027A (en) * | 2021-10-09 | 2022-01-04 | 湖北中烟工业有限责任公司 | Heterochromatic blasting bead and application thereof |
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