CN1208049C - Autonomic soft capsules and producing process thereof - Google Patents
Autonomic soft capsules and producing process thereof Download PDFInfo
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- CN1208049C CN1208049C CN 02137512 CN02137512A CN1208049C CN 1208049 C CN1208049 C CN 1208049C CN 02137512 CN02137512 CN 02137512 CN 02137512 A CN02137512 A CN 02137512A CN 1208049 C CN1208049 C CN 1208049C
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Abstract
The present invention discloses vegetal soft capsule materials and a capsule made of the materials. The capsule materials mainly contain a hydrophilic gelling agent, an adhesive and water. The vegetal soft capsule can replace the application of a gelatin soft capsule and avoid pollution possibly caused by egg albumin of animals. The present invention also discloses a preparation method of the soft capsule materials. The method can utilize the existing equipment for preparing gelatin soft capsules to prepare the vegetal soft capsule of the present invention.
Description
Technical field
The present invention relates to the material field, relate more specifically to the component and the production technology of pharmaceutical soft capsule film.
Background technology
At present, the film of soft capsule is that the gelatin that extracts with materials such as animal bone such as cattle, pig or skins is a raw material, adds glycerine fatty acid again, Sorbitol makes.Although gelatin has good characteristic when the preparation soft capsule, yet gelatin has antigenicity as heterologous protein.For example, the cattle source property gelatin materials of import may contain Protein virus, uses its soft capsule that makes as raw material may cause the diffusion of bovine spongiform encephalopathy.Along with the increase of market to the botanical material demand, the autonomic soft capsules material beyond the exploitation gelatin is extremely urgent.
Therefore, this area presses for exploitation new vegetal soft capsule material and production technology thereof.
Summary of the invention
Purpose of the present invention just provides a kind of new autonomic soft capsules material and with the capsule of this material preparation.
Another object of the present invention provides this autonomic soft capsules material or capsular preparation method.
A first aspect of the present invention, a kind of autonomic soft capsules material is provided, described soft capsule material contains hydrophilic gel, binding agent, He Shui, wherein by the gross weight of soft capsule material, the content of hydrophilic gel is 1.42%-82.88%, binder content is 7.11%-88.57%, water 10%-20%.
In another preference, described binding agent is
(1) maltose, or
(2) maltose be selected from down the group mixture of ingredients: starch, dextrin, polyvinylpyrrolidone, hypromellose, sodium carboxymethyl cellulose or its make up, and the content of maltose is not less than 50% in the wherein said mixture.
In another preference, described hydrophilic gel is selected from down group: κ type carrageenan, ι type carrageenan, arabic gum, red locust bean gum, agar, high fat pectin, low fat pectin, sodium alginate, manna glue, high acetylation gellan gum, low acetylation gellan gum, xanthan gum or its mixture.
In another preference, the autonomic soft capsules material also contains the additive that is selected from down group: plasticizer, flocculation aid, antiseptic, antioxidant, and composition thereof.
In another preference, described autonomic soft capsules material is made up of hydrophilic gel, binding agent, plasticizer, flocculation aid, antiseptic, antioxidant and water basically,
And gross weight by the soft capsule material, the percentage by weight of each component is, hydrophilic gel 1.42%-82.88%, binding agent 7.11%-88.57%, plasticizer 0.001%-50%, flocculation aid 0.001%-30%, antiseptic 0.001%-0.2%, antioxidant 0.001%-0.2%, water 10%-20%.
In another preference, plasticizer is selected from down group: glycerol, Sorbitol, Polyethylene Glycol and composition thereof;
Flocculation aid is selected from down group: potassium chloride, calcium chloride, potassium phosphate, potassium citrate and composition thereof;
Antiseptic is selected from down group: sodium benzoate, methyl parahydroxybenzoate, propyl p-hydroxybenzoate and composition thereof;
Antioxidant is selected from down group propyl gallate, tea polyphenols, phytic acid, phospholipid, L-ascorbic acid and composition thereof.
In a second aspect of the present invention, a kind of capsule is provided, it is made with autonomic soft capsules material of the present invention.
In a third aspect of the present invention, a kind of production method of autonomic soft capsules is provided, comprise step:
(a) hydrophilic gel, the binding agent of 5-40 parts by weight and the water of 28.8-94 parts by weight of mixing 1-6 parts by weight form mixture;
(b) with mixture heated to 75-95 ℃, make the colloid uniform dissolution, obtain the liquid material;
(c) the liquid material to step (b) carries out froth breaking;
(d) the liquid material of step (c) is made soft capsule.
In a preference, in step (a), also add the flocculation aid of 0.001-10 parts by weight, the antiseptic of 0.001-0.1 parts by weight and the antioxidant of 0.001-0.1 parts by weight.
In another preference, in step (c) before, also comprise the plasticizer that adds the 0.001-15 parts by weight, stir and insulation, and in step (d), adopt dropping preparation method or pressing to make soft capsule.
In a fourth aspect of the present invention, a kind of medicament capsule is provided, it comprises the capsule shell made from material of the present invention, and is positioned at medicine inclusions (being active component and pharmaceutically acceptable carrier) wherein.Preferably, described medicine inclusions is water miscible or oily.
The specific embodiment
The inventor is extensive studies through going deep into, from solving the gelatin soft capsule defective, characteristic according to the vegetalitas colloid, composite colloid, when discovery is used as binding agent with maltose (or mixture of maltose and other materials), can form the capsule material that mouthfeel is good, clarity is high with hydrophilic gel, and make ideal capsule.Finished the present invention on this basis.
The main component of autonomic soft capsules material of the present invention is hydrophilic gel, binding agent, He Shui.
Can be used for hydrophilic gel of the present invention is not particularly limited; be preferably the vegetalitas gel; representative example comprises (but being not limited to): be κ type carrageenan or ι type carrageenan, or the mixture of its arabic gum, red locust bean gum, agar, high fat pectin or low fat pectin, sodium alginate, manna glue, high acetylation gellan gum or low acetylation gellan gum, xanthan gum etc.The content of hydrophilic gel is generally 1.42%-82.89%, preferably is 2-70%, more preferably is 5-60%.
Binding agent of the present invention be maltose and with the mixture of starch or dextrin, polyvinylpyrrolidone, hypromellose, sodium carboxymethyl cellulose etc.The content of binding agent is generally 7.11%-88.58%, preferably is 8-80%, more preferably is 10-70%.In addition, maltose not only can play the binding agent effect, also can play plasticization.
The content of water is generally 10%-20%, preferably is about 12-18%.
In addition, also can add the additive of various routines in the autonomic soft capsules material of the present invention.For example, contain the additive that is selected from down group: plasticizer, flocculation aid, antiseptic, antioxidant and composition thereof.
Representational plasticizer comprises (but being not limited to): glycerol (glycerol), Sorbitol, Polyethylene Glycol and composition thereof.Press the total weight of soft capsule material, the content of plasticizer is generally 0.001%-50%.Preferably be about 1-40%.
Representational flocculation aid comprises (but being not limited to): potassium chloride, calcium chloride, potassium phosphate, potassium citrate and composition thereof.Press the total weight of soft capsule material, the content of flocculation aid is generally 0.001%-30%.Preferably be about 1-25%.
Representational antiseptic comprises (but being not limited to): sodium benzoate, methyl parahydroxybenzoate, propyl p-hydroxybenzoate and composition thereof.Press the total weight of soft capsule material, the content of antiseptic is generally 0.001%-0.2%.Preferably be about 0.01-0.19%.
Representational antioxidant comprises (but being not limited to): propyl gallate, tea polyphenols, phytic acid, phospholipid, L-ascorbic acid and composition thereof.Press the total weight of soft capsule material, the content of antioxidant is generally 0.001%-0.2%.Preferably be about 0.01-0.19%.
Usually, plasticizer dosage is relevant with soft capsule finished product soft or hard degree, and generally increases with the consumption of hydrophilic gel.Substantially, the consumption of flocculation aid and hydrophilic gel consumption are inversely proportional to.The antiseptic consumption is directly proportional substantially with binding agent maltose consumption.When using the production of rotating mould platen press, can use repeatedly in order to make film, should add antioxidant according to the consumption of maltose.
A kind of particularly preferred soft capsule material is made up of hydrophilic gel, binding agent, plasticizer, flocculation aid, antiseptic, antioxidant and water basically, wherein each weight percentages of components is, hydrophilic gel 1.42%-82.88%, binding agent 7.11%-88.57%, plasticizer 0.001%-50%, flocculation aid 0.001%-30%, antiseptic 0.001%-0.2%, antioxidant 0.001%-0.2%, water 10%-20% is by the gross weight of capsule material.
The present invention adopts hydrophilic gel and binding agent, antiseptic, antioxidant to mix, and adds water and adds flocculation aid, plasticizer, makes the soft capsule material after the heating and melting.For example, can mix the hydrophilic gel of 1-6 parts by weight, the binding agent of 5-40 parts by weight and the water of 28.8-94 parts by weight earlier, form mixture; Then with mixture heated to 75-95 ℃, make the colloid uniform dissolution, obtain the liquid material; Again the plasticizer of 0.001-50 parts by weight (preferably 0.001-15 parts by weight) is poured into, stirred, behind insulation, the bubble of cooling down, adopt dropping preparation method or pressing to make soft capsule feed liquid and medicinal liquid.After drying, softgel shell contains a certain amount of water, and general finished product contains the water of about 10-20%.
The method for preparing autonomic soft capsules of the present invention can be carried out with the equipment of existing preparation gelatin soft capsule.As required, can select dropping preparation method, steel mould platen press or rotating mould platen press and corresponding current production devices thereof to produce.Need not set in addition under the condition that is equipped with, need only can make required autonomic soft capsules according to parameters such as the corresponding adjustment temperature of prescription, coating thickness, running speeds.
When adopting dropping preparation method to produce seamless drop pill, glue temperature should maintain 85-95 ℃, 10-20 ℃ of paraffin oil temperature.
Glue oven temperature, degree is 85-95 ℃ when adopting the rotating mould platen press to produce; Wedge shape sprinkler body temperature should be 75-80 ℃, heats the rubber in its outside, can be reliably bonding during with assurance roll extrusion capsule.But improve the heat sealing property that binder dosage can improve film.Should cool off fast during the film molding, be transported in the pressing process suitably high temperature drying and go some moisture to improve rubber mechanical strengths with baking.
Compared with prior art, major advantage of the present invention is:
(1) preparation capsule used colloidal materials is for based on the vegetable polysaccharides of carrageenan (can more composite as required microbial polysaccharides), and albumen and fat content are extremely low, are the green natural composition, thereby has avoided the pollution that may be caused by the animal proteinum protein.This is not only for capsule for medicine, and also is of great importance for the demand of the growing health product of people.
(2) maltose mainly serves as the effect of binding agent in component, also can bring into play the effect of plasticizer simultaneously, can whether add the plasticizer of enumerating among the present invention according to circumstances.
(3) hydrophilic gel is easy to dissolving, can save the imbibition stage necessary when making gelatine capsule, saves the production time.
(4) tolerance to humiture makes it very convenient in use, storage and transportation.And gelatine capsule is relatively stricter to the toleration of humiture, so its application is restricted.
(5) overcome when keeping the advantage of gelatin soft capsule that gelatin soft capsule meets that high temperature, heat easily decomposes and shortcomings such as water-soluble solution that can not entrapped drug.And regulate prescription as required and can make soft capsules such as quick-acting, slow release, controlled release, enteric, gastric solubleness.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, usually according to normal condition, or the condition of advising according to manufacturer.
Embodiment 1
Soft capsule material 1
| Prescription | Consumption (content in per 100 gram gross weights) |
| κ type carrageenan | 3.5 gram |
| Maltose | 40 grams |
| Deionized water | 56.5 gram |
Manufacture method is: take by weighing κ type carrageenan 3.5 gram, maltose 40 grams are poured 56.5 gram deionized waters into, are heated to 90 ℃, dissolving evenly makes soft capsule with feed liquid and medicinal liquid employing dropping preparation method or pressing behind 92 ℃ of insulations 1-2 hour, the bubble of cooling down.In about 25 ℃ of oven dry, the capsule water content of membrane is controlled in the 10%-20%.
Contain 6.84% (by the finished product gross weight in the capsule film finished product.κ type carrageenan down together), 78.17% maltose.The capsule that finally obtains is transparent, good springiness, mouthfeel are good.
Embodiment 2
Soft capsule material 2
| Prescription | Consumption (content in per 100 gram gross weights) |
| κ type carrageenan | 4 grams |
| Maltose | 24.5 gram |
| Glycerol | 5 grams |
| Polyethylene Glycol (PEG400) | 6 grams |
| Propyl gallate | 0.05 gram |
| Sodium benzoate | 0.05 gram |
| Deionized water | 60.4 gram |
Manufacture method is: take by weighing κ type carrageenan 4 gram, maltose 24.5 grams, propyl gallate 0.05 gram, sodium benzoate 0.05 gram and pour 60.4 gram deionized waters into, be heated to 90 ℃, dissolving evenly, again 5 gram glycerol and 6 gram Polyethylene Glycol (PEG400) are poured into and stirred evenly, behind 95 ℃ of insulations 1-2 hour, the bubble of cooling down, feed liquid and medicinal liquid employing dropping preparation method or pressing are made soft capsule.In about 35 ℃ of oven dry, the capsule water content of membrane is controlled in the 10%-20%.
Contain 8.59% (by the finished product gross weight in the capsule film finished product.κ type carrageenan down together), 52.59% maltose, 10.73% glycerol, 12.88% Polyethylene Glycol (PEG400), 0.11% propyl gallate, 0.11% sodium benzoate.The capsule that finally obtains is transparent, flexible, mouthfeel is good.
Embodiment 3
Soft capsule material 3
| Prescription | Consumption (content in per 100 gram gross weights) |
| κ type carrageenan | 2 grams |
| ι type carrageenan | 1 gram |
| Maltose | 6.3 gram |
| Glycerol | 1.5 gram |
| Polyethylene Glycol (PEG400) | 3.5 gram |
| Potassium chloride | 0.5 gram |
| Calcium chloride | 0.5 gram |
| Deionized water | 84.7 gram |
Manufacture method is: take by weighing κ type carrageenan 2 gram, ι type carrageenan 1 gram, maltose 6.3 grams, potassium chloride 0.5 gram, calcium chloride 0.5 gram and pour 84.7 gram deionized waters into, be heated to 90 ℃, dissolving evenly, again 1.5 gram glycerol and 3.5 gram Polyethylene Glycol (PEG400) are poured into and stirred evenly, behind 90 ℃ of insulations 1-2 hour, the bubble of cooling down, feed liquid and medicinal liquid employing dropping preparation method or pressing are made soft capsule.In about 40 ℃ of oven dry, the capsule water content of membrane is controlled in the 10%-20%.
Contain 11.11% (by the finished product gross weight in the capsule film finished product.κ type carrageenan down together), 5.55% ι type carrageenan, 35% maltose, 8.33% glycerol, 19.44% Polyethylene Glycol (PEG400), 2.77% potassium chloride, 2.77% calcium chloride.The capsule that finally obtains is comparatively transparent, good springiness, mouthfeel are good.
Embodiment 4
Soft capsule material 4
| Prescription | Consumption (content in per 100 gram gross weights) |
| κ type carrageenan | 3.5 gram |
| Arabic gum | 1 gram |
| Maltose | 10.5 gram |
| Glycerol | 9 grams |
| Deionized water | 76 grams |
Manufacture method is: take by weighing κ type carrageenan 3.5 gram, arabic gum 1 gram, maltose 10.5 grams and pour 76 gram deionized waters into, be heated to 90 ℃, dissolving evenly, again 9 gram glycerol are poured into and stirred evenly, behind 90 ℃ of insulations 1-2 hour, the bubble of cooling down, feed liquid and medicinal liquid employing dropping preparation method or pressing are made soft capsule.In about 30 ℃ of oven dry, the capsule water content of membrane is controlled in the 10%-20%.
Contain 12.39% (by the finished product gross weight in the capsule film finished product.κ type carrageenan down together), 3.54% arabic gum, 37.19% maltose, 31.88% glycerol.The capsule that finally obtains is transparent, mechanical strength is big, mouthfeel is good.
Embodiment 5
Soft capsule material 5
| Prescription | Consumption (content in per 100 gram gross weights) |
| κ type carrageenan | 4 grams |
| Manna glue | 0.5 gram |
| Maltose | 8.4 gram |
| Sorbitol | 6 grams |
| Deionized water | 81.1 gram |
Manufacture method is: take by weighing κ type carrageenan 4 gram, manna glue 0.5 gram, maltose 8.4 grams and pour 81.1 gram deionized waters into, be heated to 90 ℃, dissolving evenly, again 6 Keshan pears sugar alcohols are poured into and stirred evenly, behind 90 ℃ of insulations 1-2 hour, the bubble of cooling down, feed liquid and medicinal liquid employing dropping preparation method or pressing are made soft capsule.In about 42 ℃ of oven dry, the capsule water content of membrane is controlled in the 10%-20%.
Contain in the capsule film finished product 17.99% (by the finished product gross weight.κ type carrageenan down together), 2.25% manna glue, 37.78% maltose, 26.98% Sorbitol.The capsule that finally obtains is transparent, surface smoothness is high, mechanical strength is big, mouthfeel is good.
Embodiment 6
Soft capsule material 6
| Prescription | Consumption (content in per 100 gram gross weights) |
| κ type carrageenan | 2 grams |
| Gellan gum | 1 gram |
| Red locust bean gum | 0.5 gram |
| Maltose | 14 grams |
| Glycerol | 6 grams |
| Sodium benzoate | 0.05 gram |
| Deionized water | 76.45 gram |
Manufacture method is: take by weighing κ type carrageenan 2 gram, gellan gum 1 gram, red locust bean gum 0.5 gram, maltose 14 grams, sodium benzoate 0.05 gram and pour 76.45 gram deionized waters into, be heated to 90 ℃, dissolving evenly, again 6 gram glycerol are poured into and stirred evenly, behind 85 ℃ of insulations 1-2 hour, the bubble of cooling down, feed liquid and medicinal liquid employing dropping preparation method or pressing are made soft capsule.In about 28 ℃ of oven dry, the capsule water content of membrane is controlled in the 10%-20%.
Contain 7.22% (weight ratio) κ type carrageenan, 3.61% gellan gum, 1.80% red locust bean gum, 50.53% maltose, 21.66% glycerol, 0.18% sodium benzoate down together in the capsule film finished product.The capsule that finally obtains is translucent, good springiness, mouthfeel are good.
Provide the example of making medicament with autonomic soft capsules agent of the present invention below.
Embodiment A
Evening Primrose Oil (parcel oily medicine)
(1) preparation of glue
Take by weighing κ type carrageenan 40 gram, maltose 245 grams, propyl gallate 0.5 gram, sodium benzoate 0.5 gram and pour 604 gram deionized waters into, be heated to 90 ℃, dissolving evenly, again 50 gram glycerol and 60 gram Polyethylene Glycol (PEG400) are poured into and stirred evenly, dissolve, 90 ℃ of insulations left standstill in 1 hour, treat the foam come-up after, remove, filter heat preservation for standby use.
(2) medicinal liquid prescription
Radix Oenotherae erythrosepalae oil 500g
Vitamin E 50g
Make 1,000
(3) preparation method
(1) getting above medicinal liquid adds in the blender and fully mixes more than 2 hours.
(2) in pellet processing machine, behind the pelleting ball put in the drum and finalize the design.
(3) in being 38 ℃ ± 2 ℃ drying room, temperature dries.
(4) product inspection is carried out packing after qualified, promptly.
(4) purposes and usage are used to prevent and treat atherosclerosis, hyperlipidemia, obesity, and be oral, every day 3 times, 1 1-2 ball.
Embodiment B
Ephedrine soft gelatin capsule (coated water-soluble medicine)
(1) preparation of glue
Take by weighing κ type carrageenan 35 gram, arabic gum 10 grams, maltose 105 grams, propyl gallate 0.2 gram, sodium benzoate 0.3 gram and pour 755 gram deionized waters into, be heated to 90 ℃, dissolving evenly, again 90 gram glycerol are poured into and stirred evenly, dissolve, 90 ℃ of insulations left standstill in 1 hour, treat the foam come-up after, remove, filter heat preservation for standby use.
(2) medicinal liquid prescription
Ephedrine (hydrochlorate) 25g
Distilled water 500ml
Make 1,000
(3) preparation method
(a) getting above medicinal liquid adds in the blender and fully mixes.
(b) in pellet processing machine, behind the pelleting ball put in the drum and finalize the design.
(c) in being 38 ℃ ± 2 ℃ drying room, temperature dries.
(d) product inspection is carried out packing after qualified, promptly.
(4) purposes and usage are used to prevent the bronchitis asthma attack to close the outbreak of alleviation mild asthma, and be oral, adult, every day 3 times, 1 time 1 ball.One after each meal.
Should be understood that those skilled in the art can make various changes or modifications the present invention after having read above-mentioned teachings of the present invention, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Claims (10)
1. autonomic soft capsules material, it is characterized in that, described soft capsule material contains hydrophilic gel, binding agent, He Shui, wherein by the gross weight of soft capsule material, the content of hydrophilic gel is 1.42%-82.88%, binder content is 7.11%-88.57%, water 10%-20%
Wherein said binding agent is
(1) maltose, or
(2) maltose be selected from down the group mixture of ingredients: starch, dextrin, polyvinylpyrrolidone, hypromellose, sodium carboxymethyl cellulose or its make up, and the content of maltose is not less than 50% in the wherein said mixture.
2. soft capsule material as claimed in claim 1 is characterized in that, described binding agent is a maltose.
3. soft capsule material as claimed in claim 1; it is characterized in that described hydrophilic gel is selected from down group: κ type carrageenan, ι type carrageenan, arabic gum, red locust bean gum, agar, high fat pectin, low fat pectin, sodium alginate, manna glue, high acetylation gellan gum, low acetylation gellan gum, xanthan gum or its mixture.
4. soft capsule material as claimed in claim 1 is characterized in that, it also contains the additive that is selected from down group: plasticizer, flocculation aid, antiseptic, antioxidant, and composition thereof.
5. soft capsule material as claimed in claim 1 is characterized in that it is made up of hydrophilic gel, binding agent, plasticizer, flocculation aid, antiseptic, antioxidant and water basically,
And gross weight by the soft capsule material, the percentage by weight of each component is, hydrophilic gel 1.42%-82.88%, binding agent 7.11%-88.57%, plasticizer 0.001%-50%, flocculation aid 0.001%-30%, antiseptic 0.001%-0.2%, antioxidant 0.001%-0.2%, water 10%-20%.
6. by the described autonomic soft capsules material of claim 5, it is characterized in that,
Plasticizer is selected from down group: glycerol, Sorbitol, Polyethylene Glycol and composition thereof;
Flocculation aid is selected from down group: potassium chloride, calcium chloride, potassium phosphate, potassium citrate and composition thereof;
Antiseptic is selected from down group: sodium benzoate, methyl parahydroxybenzoate, propyl p-hydroxybenzoate and composition thereof;
Antioxidant is selected from down group propyl gallate, tea polyphenols, phytic acid, phospholipid, L-ascorbic acid and composition thereof.
7. a capsule is characterized in that, it is made with the described autonomic soft capsules material of claim 1.
8. the production method of an autonomic soft capsules is characterized in that, comprises step:
(a) hydrophilic gel, the binding agent of 5-40 parts by weight and the water of 28.8-94 parts by weight of mixing 1-6 parts by weight, form mixture, wherein said binding agent is (1) maltose, or (2) maltose be selected from down the group mixture of ingredients: starch, dextrin, polyvinylpyrrolidone, hypromellose, sodium carboxymethyl cellulose or its make up, and the content of maltose is not less than 50% in the wherein said mixture;
(b) with mixture heated to 75-95 ℃, make the colloid uniform dissolution, obtain the liquid material;
(c) the liquid material to step (b) carries out froth breaking;
(d) the liquid material of step (c) is made soft capsule.
9. method as claimed in claim 8 is characterized in that, in step (a), also adds the flocculation aid of 0.001-10 parts by weight, the antiseptic of 0.001-0.1 parts by weight and the antioxidant of 0.001-0.1 parts by weight.
10. method as claimed in claim 8 is characterized in that, in step (c) before, also comprises the plasticizer that adds the 0.001-15 parts by weight, stirs and insulation, and in step (d), adopts dropping preparation method or pressing to make soft capsule.
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| CN 02137512 CN1208049C (en) | 2002-10-18 | 2002-10-18 | Autonomic soft capsules and producing process thereof |
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| CN 02137512 CN1208049C (en) | 2002-10-18 | 2002-10-18 | Autonomic soft capsules and producing process thereof |
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| CN1208049C true CN1208049C (en) | 2005-06-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100335134C (en) * | 2005-10-26 | 2007-09-05 | 中国药科大学 | Nimodipine soft capsule and its prepn |
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| CN100411614C (en) * | 2006-06-29 | 2008-08-20 | 郑建璋 | Production of tremella-polysaccharose capsules |
| CN101433526B (en) * | 2007-11-13 | 2012-04-18 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
| CN101961495B (en) * | 2010-09-28 | 2012-10-31 | 北京航洋健康科技有限公司 | Plant soft capsule material and preparation method thereof |
| CN102100681B (en) * | 2011-01-28 | 2012-07-25 | 广东仙乐制药有限公司 | Vegetal shell of soft capsule |
| CN104337779A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with seaweed gel and agar as capsule wall material, and its production technology |
| CN104337781A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with sodium alginate and xanthan gum as capsule wall material, and its production technology |
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| CN106214660A (en) * | 2016-08-16 | 2016-12-14 | 国家海洋局第海洋研究所 | Can be made into compositions and the soft capsule of soft capsule capsule material |
| CN106692105A (en) * | 2017-01-20 | 2017-05-24 | 广州康琪莱生物科技有限公司 | Plant soft capsule shell and ganoderma lucidum spores oil plant soft capsule and preparation methods thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100335134C (en) * | 2005-10-26 | 2007-09-05 | 中国药科大学 | Nimodipine soft capsule and its prepn |
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