CN1840109A - Chewing tablet of malt and preparation method thereof - Google Patents
Chewing tablet of malt and preparation method thereof Download PDFInfo
- Publication number
- CN1840109A CN1840109A CN 200610020141 CN200610020141A CN1840109A CN 1840109 A CN1840109 A CN 1840109A CN 200610020141 CN200610020141 CN 200610020141 CN 200610020141 A CN200610020141 A CN 200610020141A CN 1840109 A CN1840109 A CN 1840109A
- Authority
- CN
- China
- Prior art keywords
- grams
- powder
- fructus hordei
- hordei germinatus
- malt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims description 15
- 230000001055 chewing effect Effects 0.000 title abstract description 3
- 239000000843 powder Substances 0.000 claims abstract description 36
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 30
- 241000207199 Citrus Species 0.000 claims abstract description 15
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 15
- 229930195725 Mannitol Natural products 0.000 claims abstract description 15
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 15
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 15
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 15
- 239000000594 mannitol Substances 0.000 claims abstract description 15
- 235000010355 mannitol Nutrition 0.000 claims abstract description 15
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 12
- 108010010803 Gelatin Proteins 0.000 claims abstract description 9
- 229920000159 gelatin Polymers 0.000 claims abstract description 9
- 239000008273 gelatin Substances 0.000 claims abstract description 9
- 235000019322 gelatine Nutrition 0.000 claims abstract description 9
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 9
- 238000009501 film coating Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 241000209140 Triticum Species 0.000 claims description 25
- 235000021307 Triticum Nutrition 0.000 claims description 25
- 230000018984 mastication Effects 0.000 claims description 25
- 238000010077 mastication Methods 0.000 claims description 25
- 239000008187 granular material Substances 0.000 claims description 21
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 14
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 14
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 14
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 14
- 239000011812 mixed powder Substances 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 7
- 239000010409 thin film Substances 0.000 claims description 7
- 238000010790 dilution Methods 0.000 claims description 6
- 239000012895 dilution Substances 0.000 claims description 6
- 238000007654 immersion Methods 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- -1 tabletting Substances 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 2
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000007888 film coating Substances 0.000 abstract 1
- 229940013618 stevioside Drugs 0.000 abstract 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 abstract 1
- 235000019202 steviosides Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 11
- 229920002472 Starch Polymers 0.000 description 6
- KUBCEEMXQZUPDQ-UHFFFAOYSA-N hordenine Chemical compound CN(C)CCC1=CC=C(O)C=C1 KUBCEEMXQZUPDQ-UHFFFAOYSA-N 0.000 description 6
- 239000008107 starch Substances 0.000 description 6
- 235000019698 starch Nutrition 0.000 description 6
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- OQKYVRDRDIXQMK-KETMJRJWSA-N 2-(3,4-dihydroxyphenyl)-5-hydroxy-6-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-7-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1O)[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC2=C1C(=O)C=C(C=1C=C(O)C(O)=CC=1)O2 OQKYVRDRDIXQMK-KETMJRJWSA-N 0.000 description 2
- NXXWLQYGFANBST-UHFFFAOYSA-N Isoorientin-7-O-glucosid Natural products OCC1OC(Oc2cc3OC(=CC(=O)c3cc2C4OC(CO)C(O)C(O)C4O)c5ccc(O)c(O)c5)C(O)C(O)C1O NXXWLQYGFANBST-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229940064063 alpha tocotrienol Drugs 0.000 description 2
- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229940071490 hordenine Drugs 0.000 description 2
- SLJVIWCEWPUMET-UHFFFAOYSA-N lutonarin Natural products OCC1OC(Oc2cc3OC(=CC(=O)c3c(O)c2OC4OC(CO)C(O)C(O)C4O)c5ccc(O)c(O)c5)C(O)C(O)C1O SLJVIWCEWPUMET-UHFFFAOYSA-N 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 description 2
- 239000011730 α-tocotrienol Substances 0.000 description 2
- 235000019145 α-tocotrienol Nutrition 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- LTVDFSLWFKLJDQ-IEOSBIPESA-N 2-[(3r,7r,11r)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@@](C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O LTVDFSLWFKLJDQ-IEOSBIPESA-N 0.000 description 1
- HGUVPEBGCAVWID-KETMJRJWSA-N 7-O-(beta-D-glucosyl)isovitexin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1O)[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC2=C1C(=O)C=C(C=1C=CC(O)=CC=1)O2 HGUVPEBGCAVWID-KETMJRJWSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- KVYNYRIOAYQBFK-UHFFFAOYSA-N Hordatin A Natural products NC(N)=NCCCCNC(=O)C1C2=CC(C=CC(=O)NCCCCN=C(N)N)=CC=C2OC1C1=CC=C(O)C=C1 KVYNYRIOAYQBFK-UHFFFAOYSA-N 0.000 description 1
- 229930186391 Hordatine Natural products 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- ZRVSAJIGCDWADZ-UHFFFAOYSA-N Leucoanthocyanin Natural products OCC1OC(CC(O)C1O)OC2C(O)c3c(O)cc(O)cc3OC2c4ccc(O)c(O)c4 ZRVSAJIGCDWADZ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- MGZZPZRFHXCQGY-UHFFFAOYSA-N alpha-tocopheryl quinone Natural products CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OC3=CC(=O)C=CC3=O)c(C)c(C)c2O1 MGZZPZRFHXCQGY-UHFFFAOYSA-N 0.000 description 1
- LTVDFSLWFKLJDQ-UHFFFAOYSA-N alpha-tocopheryl-para-quinone Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O LTVDFSLWFKLJDQ-UHFFFAOYSA-N 0.000 description 1
- 229940020439 alpha-tocopherylquinone Drugs 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- HGUVPEBGCAVWID-UHFFFAOYSA-N saponarin Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)C2C(C(O)C(O)C(CO)O2)O)=CC2=C1C(=O)C=C(C=1C=CC(O)=CC=1)O2 HGUVPEBGCAVWID-UHFFFAOYSA-N 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a malt chewing tablet and preparing process, which consists the steps of disintegrating, drying, extracting, concentrating, palletizing, mixing, granulating, tabletting and dressing, wherein the raw material comprises (by weight percent) active component 66-70%, auxiliary materials 30-34%, the active component being malt powder and fresh malt root extract, the auxiliary materials include mannitol 19-23%, crystalline cellulose 6-10%, stevioside 0.7-1.1%, fragrant citrus powder 0.8-1.3%, and magnesium stearate 0.5-1.0%, medicinal gelatin 0.5-5.0%, and film coating material 3.3%.
Description
Technical field
The present invention relates to a kind of spleen benefiting and stimulating the appetite, help digestion and remove Fructus Hordei Germinatus oral Chinese patent medicine preparation that expands and preparation method thereof, particularly a kind of absorption is fast, curative effect is high, take and carry wheat germ mastication tablet and preparation method thereof more easily.
Background technology
Fructus Hordei Germinatus (Malt) for the mature fruit of grass Fructus Hordei Vulgaris gets through germination, claims Fructus Hordei Vulgaris (Barley) bud again, in the history in existing hundreds of years of China, records in Compendium of Material Medica the earliest.Compendium of Material Medica cloud: " digest all rice, face, all fruit food stagnations." " book on Chinese herbal medicine converge with speech " " Fructus Hordei Germinatus and in the medicine that helps digestion also, mend and can be sharp, sharp and can mend.As the distension of abdomen, every pent-up, or not the receiving of diet, middle gas unfavorable, with this thing that the takes place gas of switch lattice is then imitated very than also "." Records of Tradition Chinese and Western Medicine in Combination " " Fructus Hordei Germinatus can be gone into taste, digests all diet and gathers, and is the product of assisting a ruler in governing a country of subsidy taste ".Fructus Hordei Germinatus is traditional medicinal and edible Chinese medicine, the starch-containing hydrolytic enzyme of Fructus Hordei Germinatus, protease, starch, protein, maltose, vitamin B, α-Ke quinone (α-Tocopherylquinone), alpha-tocotrienol (α-Tocotrienol) etc., and carbon containing glucosyl group flavone-saponarin (Saponarin) and lutonarin (lutonarin); Still contain leucoanthocyanin, anhaline (Hordenine).Other has report, has also isolated hordenine (Hordatine) A, B and glycoside thereof from Fructus Hordei Germinatus.The Fructus Hordei Germinatus medicinal preparation for oral administration has spleen benefiting and stimulating the appetite, helps digestion to remove bloated effect, can be used for food stagnation and does not disappear, abdominal distention, insufficiency of the spleen lack of appetite.Its clinical efficacy is not seen the clinical report of toxic side effect certainly.
The malt peroral dosage form that has gone on the market at present only has tablet, but it exists disintegrate slow, and bioavailability is not high, especially all slower shortcoming of drug absorption and produce effects.Therefore, develop a kind of excellent taste of chewing, absorb fast and the high Fructus Hordei Germinatus oral formulations of curative effect has very wide prospect.
Summary of the invention
The present invention is intended to overcome above-mentioned defective, provides a kind of mouthfeel good, easy to carry, and the bioavailability height absorbs soon, and is quality controllable, wheat germ mastication tablet that curative effect is high and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of wheat germ mastication tablet, raw material is formed and is comprised active component and adjuvant, and it is formulated to it is characterized in that it presses column weight amount percentage ratio: active component 66～70%, adjuvant 30～34%.
Described active component is for pressing quantitative Fructus Hordei Germinatus powder of its saccharifying enzymic activity and bright malt fibrous root extract.
Described adjuvant adds in the active component for pressing column weight amount percentage ratio:
A, mannitol 19～23%
B, microcrystalline Cellulose 6～10%
C, steviosin 0.7～1.1%
D, fragrant citrus powder 0.8～1.3%
E, magnesium stearate 0.5～1.0%
F, pharmagel 0.5～5.0%
G, thin film coating material 3.3%
Wherein, mannitol is good filler, can make mouthfeel that coolness is arranged; Microcrystalline Cellulose is water insoluble, and good compressibility is arranged, and has effect such as bonding, fluidizer concurrently, and medicine is had bigger saturation, is tabletting dry adhesive and good filler; Steviosin is as correctives, and the fragrant citrus powder is as aromatic; Magnesium stearate is a lubricant, and lubricity is strong, and anti-adhesive is good.
Operations such as the preparation method of described wheat germ mastication tablet comprises pulverizing, drying, extraction, concentrates, granulation, mixing, granulate, tabletting, coating, its concrete processing step is as follows:
A, get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to 0.4～0.6cm, remove fibrous root and preserve with other device, after the Fructus Hordei Germinatus cold drying, usefulness high pressure draught micronizing is to impalpable powder, and is standby.
B, Fibrous root of Fructus Hordei Germinatus is soaked twice with 70～85 ℃ of hydro-thermals, 1.2～1.8 hours for the first time, 0.6～1.3 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, being evaporated to relative density is the clear paste of 1.25 (18～26 ℃), promptly gets bright malt fibrous root extract.
C, take by weighing steps A gained Fructus Hordei Germinatus powder, add mannitol by above-mentioned percentage by weight, microcrystalline Cellulose, mixing, mixed powder.
D, get the bright malt fibrous root extract of step B, add the gelatin solution dilution of 220ml10% by every 4g after, again it is added in the mixed powder of step C, granulate cold drying.
E, the dried granule of step D carried out granulate after, add steviosin, fragrant citrus powder, magnesium stearate, mixing, tabletting, coating promptly make the wheat germ mastication tablet finished product.
The specification of described wheat germ mastication tablet finished product is: every heavily is 0.75 gram.
The invention has the advantages that:
1, directly be used as medicine with the Fructus Hordei Germinatus fine powder, add adjuvant, and adopt the film-making of wet granule compression tablet method, its preparation technology is simple, and easy operating has reduced production cost.
2, the present invention is under the condition that does not increase unit preparation medicine content, by improving the drug administration mode, thereby improved cost performance and the therapeutic index of medicine on the therapeutics meaning greatly.
3, wheat germ mastication tablet of the present invention need not be swallowed and adopt and chew, and need not carry out disintegrate, and conventional formulation generally then needs ability disintegrate beading or block more than 30 minutes, and it is low thoroughly to have changed Chinese patent medicine oral formulations disintegration, absorbs the slow common fault that takes effect in the body.
4, wheat germ mastication tablet of the present invention has high bioavailability, and it is fast to absorb produce effects.
The specific embodiment
Embodiment 1
A kind of wheat germ mastication tablet is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.5 grams
Mannitol 125 grams
Microcrystalline Cellulose 70 grams
Steviosin 6 grams
Fragrant citrus powder 8 grams
Magnesium stearate 4 grams
Pharmagel 22 grams
Thin film coating material 25 grams
Make 1000 altogether
The preparation method of wheat germ mastication tablet of the present invention is as follows:
A, get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to about 0.5cm, remove fibrous root, device is preserved in addition, and is after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing;
B, the steps A Fibrous root of Fructus Hordei Germinatus is soaked secondary with 80 ℃ of hydro-thermals, 1.5 hours for the first time, 1 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, be evaporated to relative density and be the bright malt fibrous root extract of 1.25 (18～26 ℃), standby;
C, take by weighing Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose by above-mentioned weight proportion, mixing, mixed powder;
D, bright malt fibrous root extract that step B is made with 10% gelatin solution dilution after, add in the mixed powder, granulate cold drying;
E, the dried granule of step D carried out granulate after, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, the bag film-coat forms sheet and heavily is 750 milligrams wheat germ mastication tablet.
Saccharifying power test determination result: the starch conversional solution of consumption is less than 7.5ml.
Embodiment 2
A kind of wheat germ mastication tablet is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.2 grams
Mannitol 137 grams
Microcrystalline Cellulose 60 grams
Steviosin 7 grams
Fragrant citrus powder 8 grams
Magnesium stearate 5 grams
Pharmagel 7.5 grams
Thin film coating material 25 grams
Make 1000 altogether
The preparation method of wheat germ mastication tablet of the present invention is as follows:
Get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to about 0.5cm, remove fibrous root, preserve with other device, after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing; Fibrous root of Fructus Hordei Germinatus is soaked secondary with 70 ℃ of hydro-thermals, 1.8 hours for the first time, 1 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, be evaporated to relative density and be the bright malt fibrous root extract of 1.25 (18～26 ℃), standby; By above-mentioned weight proportion, in Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose, mixing gets mixed powder; Get above-mentioned bright malt fibrous root extract with after the gelatin solution dilution, add in the mixed powder, granulate cold drying; After dried granule carried out granulate, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, and the bag film-coat forms sheet and heavily be 750 milligrams wheat germ mastication tablet.
Saccharifying power test determination result: the starch conversional solution of consumption is less than 7.5ml.
Embodiment 3
A kind of wheat germ mastication tablet is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 3.5 grams
Mannitol 126 grams
Microcrystalline Cellulose 55 grams
Steviosin 7 grams
Fragrant citrus powder 10 grams
Magnesium stearate 7 grams
Pharmagel 29.5 grams
Thin film coating material 25 grams
Make 1000 altogether
The preparation method of wheat germ mastication tablet of the present invention is as follows:
Get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to about 0.5cm, remove fibrous root, preserve with other device, after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing; Fibrous root of Fructus Hordei Germinatus is soaked secondary with 85 ℃ of hydro-thermals, 1.2 hours for the first time, 0.6 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, be evaporated to relative density and be the bright malt fibrous root extract of 1.25 (18～26 ℃), standby; By above-mentioned weight proportion, in Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose, mixing gets mixed powder; Get above-mentioned bright malt fibrous root extract with the dilution of 10% gelatin solution after, add in the mixed powder, granulate cold drying; After dried granule carried out granulate, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, and the bag film-coat forms sheet and heavily be 750 milligrams wheat germ mastication tablet.
Saccharifying power test determination result: the starch conversional solution of consumption is less than 7.5ml.
Embodiment 4
A kind of wheat germ mastication tablet is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.1 grams
Mannitol 145 grams
Microcrystalline Cellulose 64 grams
Steviosin 7 grams
Fragrant citrus powder 9 grams
Magnesium stearate 5 grams
Medical gelatin 5.5 grams
Thin film coating material 25 grams
Make 1000 altogether
The preparation method of wheat germ mastication tablet of the present invention is as follows:
Get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to about 0.5cm, remove fibrous root, preserve with other device, after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing; Fibrous root of Fructus Hordei Germinatus is soaked secondary with 75 ℃ of hydro-thermals, 1.5 hours for the first time, 1.3 hours for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, be evaporated to relative density and be the bright malt fibrous root extract of 1.25 (18～26 ℃), standby; By above-mentioned weight proportion, in Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose, mixing gets mixed powder; Get above-mentioned bright malt fibrous root extract with 10% natural gelatin solution dilution after, add in the mixed powder, granulate cold drying; After dried granule carried out granulate, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, and the bag film-coat forms sheet and heavily be 750 milligrams wheat germ mastication tablet.
Saccharifying power test determination result: the starch conversional solution of consumption is less than 7.5ml.
Claims (3)
1, a kind of wheat germ mastication tablet, raw material is formed and is comprised active component and adjuvant, and it is formulated to it is characterized in that it presses column weight amount percentage ratio: active component 66～70%, adjuvant 30～34%;
Described active component is for pressing quantitative Fructus Hordei Germinatus powder of its saccharifying enzymic activity and bright malt fibrous root extract;
Described adjuvant adds in the active component for pressing column weight amount percentage ratio:
A, mannitol 19～23%
B, microcrystalline Cellulose 6～10%
C, steviosin 0.7～1.1%
D, fragrant citrus powder 0.8～1.3%
E, magnesium stearate 0.5～1.0%
F, pharmagel 0.5～5.0%
G, thin film coating material 3.3%.
2, wheat germ mastication tablet according to claim 1 is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.1 grams
Mannitol 145 grams
Microcrystalline Cellulose 64 grams
Steviosin 7 grams
Fragrant citrus powder 9 grams
Magnesium stearate 5 grams
Medical gelatin 5.5 grams
Thin film coating material 25 grams.
3, the preparation method of wheat germ mastication tablet according to claim 1 and 2 is characterized in that comprising pulverizing, drying, extraction, concentrates, granulation, mixing, granulate, tabletting, coating operation, and its concrete processing step is as follows:
A, get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to 0.4～0.6cm, remove fibrous root and preserve with other device, after the Fructus Hordei Germinatus cold drying, usefulness high pressure draught micronizing is to impalpable powder, and is standby;
B, Fibrous root of Fructus Hordei Germinatus is soaked twice with 70～85 ℃ of hydro-thermals, 1.2～1.8 hours for the first time, 0.6～1.3 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, being evaporated to relative density is the clear paste of 1.25 (18～26 ℃), promptly gets bright malt fibrous root extract;
C, take by weighing steps A gained Fructus Hordei Germinatus powder, add mannitol by above-mentioned percentage by weight, microcrystalline Cellulose, mixing, mixed powder;
D, get the bright malt fibrous root extract of step B, add the gelatin solution dilution of 220ml 10% by every 4g after, again it is added in the mixed powder of step C, granulate cold drying;
E, the dried granule of step D carried out granulate after, add steviosin, fragrant citrus powder, magnesium stearate, mixing, tabletting, coating promptly make the wheat germ mastication tablet finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610020141A CN100579515C (en) | 2006-01-12 | 2006-01-12 | Chewing tablet of malt and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610020141A CN100579515C (en) | 2006-01-12 | 2006-01-12 | Chewing tablet of malt and preparation method thereof |
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| CN1840109A true CN1840109A (en) | 2006-10-04 |
| CN100579515C CN100579515C (en) | 2010-01-13 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940259A (en) * | 2012-12-05 | 2013-02-27 | 中国科学院昆明植物研究所 | Extraction method of raw malt |
| CN105147629A (en) * | 2015-09-24 | 2015-12-16 | 吉林大学 | Isobutyl ketone tablet and preparation method |
| CN105379870A (en) * | 2015-12-08 | 2016-03-09 | 成都大学 | Cracking and puncturing device for malt silk tea |
| CN106360357A (en) * | 2016-08-31 | 2017-02-01 | 广东博识环境化学研究所（有限合伙） | Health-care food chewable tablets for improving immunity and delaying senility and preparation method thereof |
-
2006
- 2006-01-12 CN CN200610020141A patent/CN100579515C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940259A (en) * | 2012-12-05 | 2013-02-27 | 中国科学院昆明植物研究所 | Extraction method of raw malt |
| CN105147629A (en) * | 2015-09-24 | 2015-12-16 | 吉林大学 | Isobutyl ketone tablet and preparation method |
| CN105147629B (en) * | 2015-09-24 | 2017-08-25 | 吉林大学 | A kind of sharp ketone tablet of isobutyl and preparation method |
| CN105379870A (en) * | 2015-12-08 | 2016-03-09 | 成都大学 | Cracking and puncturing device for malt silk tea |
| CN106360357A (en) * | 2016-08-31 | 2017-02-01 | 广东博识环境化学研究所（有限合伙） | Health-care food chewable tablets for improving immunity and delaying senility and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100579515C (en) | 2010-01-13 |
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