CN100579515C - Chewing tablet of malt and preparation method thereof - Google Patents
Chewing tablet of malt and preparation method thereof Download PDFInfo
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- CN100579515C CN100579515C CN200610020141A CN200610020141A CN100579515C CN 100579515 C CN100579515 C CN 100579515C CN 200610020141 A CN200610020141 A CN 200610020141A CN 200610020141 A CN200610020141 A CN 200610020141A CN 100579515 C CN100579515 C CN 100579515C
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- fructus hordei
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- hordei germinatus
- fibrous root
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Abstract
The invention relates to a malt chewing tablet and preparing process, which consists the steps of disintegrating, drying, extracting, concentrating, palletizing, mixing, granulating, tabletting and dressing, wherein the raw material comprises (by weight percent) active component 66-70%, auxiliary materials 30-34%, the active component being malt powder and fresh malt root extract, the auxiliary materials include mannitol 19-23%, crystalline cellulose 6-10%, stevioside 0.7-1.1%, fragrant citrus powder 0.8-1.3%, and magnesium stearate 0.5-1.0%, medicinal gelatin 0.5-5.0%, and film coating material 3.3%.
Description
Technical field
The present invention relates to a kind of spleen benefiting and stimulating the appetite, help digestion and remove Fructus Hordei Germinatus oral Chinese patent medicine preparation that expands and preparation method thereof, particularly a kind of absorption is fast, curative effect is high, take and carry wheat germ mastication tablet and preparation method thereof more easily.
Background technology
Fructus Hordei Germinatus (Malt) for the mature fruit of grass Fructus Hordei Vulgaris gets through germination, claims Fructus Hordei Vulgaris (Barley) bud again, in the history in existing hundreds of years of China, records in Compendium of Material Medica the earliest.Compendium of Material Medica cloud: " digest all rice, face, all fruit food stagnations." " book on Chinese herbal medicine converge with speech " " Fructus Hordei Germinatus and in the medicine that helps digestion also, mend and can be sharp, sharp and can mend.As the distension of abdomen, every pent-up, or not the receiving of diet, middle gas unfavorable, with this thing that the takes place gas of switch lattice is then imitated very than also "." Records of Tradition Chinese and Western Medicine in Combination " " Fructus Hordei Germinatus can be gone into taste, digests all diet and gathers, and is the product of assisting a ruler in governing a country of subsidy taste ".Fructus Hordei Germinatus is traditional medicinal and edible Chinese medicine, the starch-containing hydrolytic enzyme of Fructus Hordei Germinatus, protease, starch, protein, maltose, vitamin B, α-Ke quinone (α-Tocopherylquinone), alpha-tocotrienol (α-Tocotrienol) etc., and carbon containing glucosyl group flavone-saponarin (Saponarin) and lutonarin (lutonarin); Still contain leucoanthocyanin, anhaline (Hordenine).Other has report, has also isolated hordenine (Hordatine) A, B and glycoside thereof from Fructus Hordei Germinatus.The Fructus Hordei Germinatus medicinal preparation for oral administration has spleen benefiting and stimulating the appetite, helps digestion to remove bloated effect, can be used for food stagnation and does not disappear, abdominal distention, insufficiency of the spleen lack of appetite.Its clinical efficacy is not seen the clinical report of toxic side effect certainly.
The malt peroral dosage form that has gone on the market at present only has tablet, but it exists disintegrate slow, and bioavailability is not high, especially all slower shortcoming of drug absorption and produce effects.Therefore, develop a kind of excellent taste of chewing, absorb fast and the high Fructus Hordei Germinatus oral formulations of curative effect has very wide prospect.
Summary of the invention
The present invention is intended to overcome above-mentioned defective, provides a kind of mouthfeel good, easy to carry, and the bioavailability height absorbs soon, and is quality controllable, wheat germ mastication tablet that curative effect is high and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of wheat germ mastication tablet, raw material is formed and is comprised active component and adjuvant, and it is formulated to it is characterized in that it presses column weight amount percentage ratio: active component 66～70%, adjuvant 30～34%.
Described active component is for pressing quantitative Fructus Hordei Germinatus powder of its saccharifying enzymic activity and bright malt fibrous root extract.
Described adjuvant adds in the active component for pressing column weight amount percentage ratio:
A, mannitol 19～23%
B, microcrystalline Cellulose 6～10%
C, steviosin 0.7～1.1%
D, fragrant citrus powder 0.8～1.3%
E, magnesium stearate 0.5～1.0%
F, pharmagel 0.5～5.0%
G, thin film coating material 3.3%
Wherein, mannitol is good filler, can make mouthfeel that coolness is arranged; Microcrystalline Cellulose is water insoluble, and good compressibility is arranged, and has effect such as bonding, fluidizer concurrently, and medicine is had bigger saturation, is tabletting dry adhesive and good filler; Steviosin is as correctives, and the fragrant citrus powder is as aromatic; Magnesium stearate is a lubricant, and lubricity is strong, and anti-adhesive is good.
Operations such as the preparation method of described wheat germ mastication tablet comprises pulverizing, drying, extraction, concentrates, granulation, mixing, granulate, tabletting, coating, its concrete processing step is as follows:
A, get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to 0.4～0.6cm, remove fibrous root and preserve with other device, after the Fructus Hordei Germinatus cold drying, usefulness high pressure draught micronizing is to impalpable powder, and is standby.
B, Fibrous root of Fructus Hordei Germinatus is soaked twice with 70～85 ℃ of hydro-thermals, 1.2～1.8 hours for the first time, 0.6～1.3 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, being evaporated to relative density is the clear paste of 1.25 (18～26 ℃), promptly gets bright malt fibrous root extract.
C, take by weighing steps A gained Fructus Hordei Germinatus powder, add mannitol by above-mentioned percentage by weight, microcrystalline Cellulose, mixing, mixed powder.
D, get the bright malt fibrous root extract of step B, add the gelatin solution dilution of 220ml 10% by every 4g after, again it is added in the mixed powder of step C, granulate cold drying.
E, the dried granule of step D carried out granulate after, add steviosin, fragrant citrus powder, magnesium stearate, mixing, tabletting, coating promptly make the wheat germ mastication tablet finished product.
The specification of described wheat germ mastication tablet finished product is: every heavily is 0.75 gram.
The invention has the advantages that:
1, directly be used as medicine with the Fructus Hordei Germinatus fine powder, add adjuvant, and adopt the film-making of wet granule compression tablet method, its preparation technology is simple, and easy operating has reduced production cost.
2, the present invention is under the condition that does not increase unit preparation medicine content, by improving the drug administration mode, thereby improved cost performance and the therapeutic index of medicine on the therapeutics meaning greatly.
3, wheat germ mastication tablet of the present invention need not be swallowed and adopt and chew, and need not carry out disintegrate, and conventional formulation generally then needs ability disintegrate beading or block more than 30 minutes, and it is low thoroughly to have changed Chinese patent medicine oral formulations disintegration, absorbs the slow common fault that takes effect in the body.
4, wheat germ mastication tablet of the present invention has high bioavailability, and it is fast to absorb produce effects.
The specific embodiment
Embodiment 1
A kind of wheat germ mastication tablet is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.5 grams
Mannitol 125 grams
Microcrystalline Cellulose 70 grams
Steviosin 6 grams
Fragrant citrus powder 8 grams
Magnesium stearate 4 grams
Pharmagel 22 grams
Thin film coating material 25 grams
Make 1000 altogether
The preparation method of wheat germ mastication tablet of the present invention is as follows:
A, get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to about 0.5cm, remove fibrous root, device is preserved in addition, and is after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing;
B, the steps A Fibrous root of Fructus Hordei Germinatus is soaked secondary with 80 ℃ of hydro-thermals, 1.5 hours for the first time, 1 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, be evaporated to relative density and be the bright malt fibrous root extract of 1.25 (18～26 ℃), standby;
C, take by weighing Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose by above-mentioned weight proportion, mixing, mixed powder;
D, bright malt fibrous root extract that step B is made with 10% gelatin solution dilution after, add in the mixed powder, granulate cold drying;
E, the dried granule of step D carried out granulate after, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, the bag film-coat forms sheet and heavily is 750 milligrams wheat germ mastication tablet.
Saccharifying power test determination result: the starch conversional solution of consumption is less than 7.5ml.
Embodiment 2
A kind of wheat germ mastication tablet is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.2 grams
Mannitol 137 grams
Microcrystalline Cellulose 60 grams
Steviosin 7 grams
Fragrant citrus powder 8 grams
Magnesium stearate 5 grams
Pharmagel 7.5 grams
Thin film coating material 25 grams
Make 1000 altogether
The preparation method of wheat germ mastication tablet of the present invention is as follows:
Get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to about 0.5cm, remove fibrous root, preserve with other device, after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing; Fibrous root of Fructus Hordei Germinatus is soaked secondary with 70 ℃ of hydro-thermals, 1.8 hours for the first time, 1 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, be evaporated to relative density and be the bright malt fibrous root extract of 1.25 (18～26 ℃), standby; By above-mentioned weight proportion, in Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose, mixing gets mixed powder; Get above-mentioned bright malt fibrous root extract with after the gelatin solution dilution, add in the mixed powder, granulate cold drying; After dried granule carried out granulate, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, and the bag film-coat forms sheet and heavily be 750 milligrams wheat germ mastication tablet.
Saccharifying power test determination result: the starch conversional solution of consumption is less than 7.5ml.
Embodiment 3
A kind of wheat germ mastication tablet is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 3.5 grams
Mannitol 126 grams
Microcrystalline Cellulose 55 grams
Steviosin 7 grams
Fragrant citrus powder 10 grams
Magnesium stearate 7 grams
Pharmagel 29.5 grams
Thin film coating material 25 grams
Make 1000 altogether
The preparation method of wheat germ mastication tablet of the present invention is as follows:
Get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to about 0.5cm, remove fibrous root, preserve with other device, after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing; Fibrous root of Fructus Hordei Germinatus is soaked secondary with 85 ℃ of hydro-thermals, 1.2 hours for the first time, 0.6 hour for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, be evaporated to relative density and be the bright malt fibrous root extract of 1.25 (18～26 ℃), standby; By above-mentioned weight proportion, in Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose, mixing gets mixed powder; Get above-mentioned bright malt fibrous root extract with the dilution of 10% gelatin solution after, add in the mixed powder, granulate cold drying; After dried granule carried out granulate, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, and the bag film-coat forms sheet and heavily be 750 milligrams wheat germ mastication tablet.
Saccharifying power test determination result: the starch conversional solution of consumption is less than 7.5ml.
Embodiment 4
A kind of wheat germ mastication tablet is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.1 grams
Mannitol 145 grams
Microcrystalline Cellulose 64 grams
Steviosin 7 grams
Fragrant citrus powder 9 grams
Magnesium stearate 5 grams
Medical gelatin 5.5 grams
Thin film coating material 25 grams
Make 1000 altogether
The preparation method of wheat germ mastication tablet of the present invention is as follows:
Get the bright Fructus Hordei Germinatus of the Fructus Hordei Vulgaris that grows to about 0.5cm, remove fibrous root, preserve with other device, after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing; Fibrous root of Fructus Hordei Germinatus is soaked secondary with 75 ℃ of hydro-thermals, 1.5 hours for the first time, 1.3 hours for the second time, merge immersion, left standstill 24 hours, get supernatant and filter, be evaporated to relative density and be the bright malt fibrous root extract of 1.25 (18～26 ℃), standby; By above-mentioned weight proportion, in Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose, mixing gets mixed powder; Get above-mentioned bright malt fibrous root extract with 10% natural gelatin solution dilution after, add in the mixed powder, granulate cold drying; After dried granule carried out granulate, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, and the bag film-coat forms sheet and heavily be 750 milligrams wheat germ mastication tablet.
Saccharifying power test determination result: the starch conversional solution of consumption is less than 7.5ml.
Claims (2)
1, a kind of spleen benefiting and stimulating the appetite, the wheat germ mastication tablet that helps digestion and remove to expand is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.1 grams
Mannitol 145 grams
Microcrystalline Cellulose 64 grams
Steviosin 7 grams
Fragrant citrus powder 9 grams
Magnesium stearate 5 grams
Medical gelatin 5.5 grams
Thin film coating material 25 grams
Get the bright Fructus Hordei Germinatus of the Fructus Hordei Germinatus that grows to 0.5cm, remove fibrous root, preserve with other device, after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing; Fibrous root of Fructus Hordei Germinatus is soaked secondary with 75 ℃ of hydro-thermals, 1.5 hours for the first time, 1.3 hours for the second time, merge immersion, left standstill 24 hours, to get supernatant and filter, relative density is 1.25 bright malt fibrous root extract when being evaporated to 18-26 ℃, and is standby; By above-mentioned weight proportion, in Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose, mixing gets mixed powder; Get above-mentioned bright malt fibrous root extract with 10% medical gelatin solution dilution after, add in the mixed powder, granulate cold drying; After dried granule carried out granulate, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, and the bag film-coat forms sheet and heavily be 750 milligrams wheat germ mastication tablet.
2, the preparation method of wheat germ mastication tablet according to claim 1 is characterized in that it is to press column weight amount proportion raw material to be mixed with 1000:
Fructus Hordei Germinatus powder 500 grams
Bright malt fibrous root extract 4.1 grams
Mannitol 145 grams
Microcrystalline Cellulose 64 grams
Steviosin 7 grams
Fragrant citrus powder 9 grams
Magnesium stearate 5 grams
Medical gelatin 5.5 grams
Thin film coating material 25 grams
Get the bright Fructus Hordei Germinatus of the Fructus Hordei Germinatus that grows to 0.5cm, remove fibrous root, preserve with other device, after the Fructus Hordei Germinatus cold drying, to impalpable powder, standby with the high pressure draught micronizing; Fibrous root of Fructus Hordei Germinatus is soaked secondary with 75 ℃ of hydro-thermals, 1.5 hours for the first time, 1.3 hours for the second time, merge immersion, left standstill 24 hours, to get supernatant and filter, relative density is 1.25 bright malt fibrous root extract when being evaporated to 18-26 ℃, and is standby; By above-mentioned weight proportion, in Fructus Hordei Germinatus powder, add mannitol and microcrystalline Cellulose, mixing gets mixed powder; Get above-mentioned bright malt fibrous root extract with 10% medical gelatin solution dilution after, add in the mixed powder, granulate cold drying; After dried granule carried out granulate, add steviosin, fragrant citrus powder, magnesium stearate, mixing is pressed into 1000, and the bag film-coat forms sheet and heavily be 750 milligrams wheat germ mastication tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610020141A CN100579515C (en) | 2006-01-12 | 2006-01-12 | Chewing tablet of malt and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610020141A CN100579515C (en) | 2006-01-12 | 2006-01-12 | Chewing tablet of malt and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1840109A CN1840109A (en) | 2006-10-04 |
| CN100579515C true CN100579515C (en) | 2010-01-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200610020141A Expired - Fee Related CN100579515C (en) | 2006-01-12 | 2006-01-12 | Chewing tablet of malt and preparation method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940259A (en) * | 2012-12-05 | 2013-02-27 | 中国科学院昆明植物研究所 | Extraction method of raw malt |
| CN105147629B (en) * | 2015-09-24 | 2017-08-25 | 吉林大学 | A kind of sharp ketone tablet of isobutyl and preparation method |
| CN105379870A (en) * | 2015-12-08 | 2016-03-09 | 成都大学 | Cracking and puncturing device for malt silk tea |
| CN106360357A (en) * | 2016-08-31 | 2017-02-01 | 广东博识环境化学研究所（有限合伙） | Health-care food chewable tablets for improving immunity and delaying senility and preparation method thereof |
-
2006
- 2006-01-12 CN CN200610020141A patent/CN100579515C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部药品标准中药成方制剂. 卫生部药典委员会，68. 1993 |
| 中华人民共和国卫生部药品标准中药成方制剂. 卫生部药典委员会，68. 1993 * |
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| CN1840109A (en) | 2006-10-04 |
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Granted publication date: 20100113 Termination date: 20140112 |