CN101116675A - Antihyperglycemic antisenescence medicinal composition and method for preparing the same - Google Patents
Antihyperglycemic antisenescence medicinal composition and method for preparing the same Download PDFInfo
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- CN101116675A CN101116675A CNA2007100589603A CN200710058960A CN101116675A CN 101116675 A CN101116675 A CN 101116675A CN A2007100589603 A CNA2007100589603 A CN A2007100589603A CN 200710058960 A CN200710058960 A CN 200710058960A CN 101116675 A CN101116675 A CN 101116675A
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- arithoke
- folium
- ilicis
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Abstract
The present invention discloses a lipid-lowering and anti-aging drug combination and the preparation method thereof; according to percentage by weight, the lipid-lowering and anti-aging drug combination consists of the following components: 30 to 70 percent of artichoke, 25 to 50 percent of ilexlatifolia thumb and 0 to 20 percent of senna. The lipid-lowering and anti-aging drug combination of the invention comprises biological total flavanoid, biological saponin and other active ingredients, thereby achieving good lipid-lowering effect through comprehensive adjustment of environment inside an organism.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly relate to a kind of antihyperglycemic antisenescence medicinal composition and preparation method thereof.
Background technology
Obesity is a kind of common disease, is 10%～20% at its sickness rate of China.Obesity not only influences figure and activity, and the low ventilation of easy concurrent hyperlipemia, atherosclerosis, coronary heart disease, hypertension, diabetes, gout, fatty liver, endocrine disturbance, alveolar syndrome, cholecystitis, and make the lower for the resistance of human body and easy infection, lengthen the life and impair one's health so hinder.It is of common occurrence to take the improper example that serious side effects even poisoning occur of appetrol in recent years.Therefore, scientifically the control obesity is one of measure that keeps healthy, lengthens the life.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of antihyperglycemic antisenescence medicinal composition is provided.
Second purpose of the present invention provides a kind of preparation method of antihyperglycemic antisenescence medicinal composition.
A kind of antihyperglycemic antisenescence medicinal composition is made up of following component: arithoke 30%-70%, Folium Ilicis 25%-50%, Folium Sennae 0%-20% by weight percentage.
Preferably: described arithoke is 50%, and Folium Ilicis is 40%, and Folium Sennae is 10%.
Preferably: described arithoke is 55%, and Folium Ilicis is 35%, and Folium Sennae is 10%.
Preferably: described arithoke is 60%, and Folium Ilicis is 40%.
A kind of preparation method of antihyperglycemic antisenescence medicinal composition comprises the steps: that (1) takes by weighing by weight percentage: arithoke 30%-70%, Folium Ilicis 25%-50%, Folium Sennae 0%-20%; (2) the arithoke extracting in water is 1-3 time, each amount of water be arithoke weight 6-12 doubly, extraction time is 1-3 hour, extracting solution filters, filtrate reclaim and when being concentrated into 80 ℃ relative density be 1.00-1.20, carry out spray drying, cynara scolymus extracts; Folium Ilicis extracting in water 1-3 time, each amount of water be Folium Ilicis weight 6-12 doubly, extraction time is 1-3 hour, extracting solution filters, relative density was 1.00-1.20 when filtrate was concentrated into 80 ℃, carried out spray drying, Folum Ilicis extract; Garfields Tea is broken into fine powder; (3) cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously are made.
Preferred step is: (1) takes by weighing by weight percentage: arithoke 50%, Folium Ilicis 40%, Folium Sennae 10%; (2) the arithoke extracting in water is 2 times, and for the first time amount of water is 10 times of arithoke weight, extracts 2 hours, for the second time amount of water is 8 times of arithoke weight, extracts the extracting solution filtration 2 hours, relative density 1.00-1.10 when filtrate is concentrated into 80 ℃ carries out spray drying, gets cynara scolymus extracts; Folium Ilicis extracting in water 2 times, for the first time amount of water is 10 times of Folium Ilicis weight, extracts 2 hours, for the second time amount of water is 8 times of Folium Ilicis weight, extracts the extracting solution filtration 2 hours, relative density 1.00-1.10 when filtrate is concentrated into 80 ℃ carries out spray drying, gets Folum Ilicis extract; Garfields Tea is broken into fine powder; (3) cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously are made.
Described arithoke is 55%, and Folium Ilicis is 35%, and Folium Sennae is 10%.
Described arithoke is 60%, and Folium Ilicis is 40%, and Folium Sennae is 0%.
A kind of antihyperglycemic antisenescence medicinal composition effect of the present invention is remarkable, and it includes biological general flavone compositions of the present invention, and biological saponin isoreactivity composition by the across-the-board regulation to organismic internal environment, reaches good effect for reducing fat.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment:
Embodiment 1
A kind of antihyperglycemic antisenescence medicinal composition, be made up of following component by weight percentage: arithoke is 50%, and Folium Ilicis is 40%, and Folium Sennae is 10%.
Embodiment 2
A kind of antihyperglycemic antisenescence medicinal composition, be made up of following component by weight percentage: arithoke is 30%, and Folium Ilicis is 50%, and Folium Sennae is 20%.
Embodiment 3
A kind of antihyperglycemic antisenescence medicinal composition, be made up of following component by weight percentage: arithoke is 70%, and Folium Ilicis is 25%, and Folium Sennae is 5%.
Embodiment 4
A kind of antihyperglycemic antisenescence medicinal composition, be made up of following component by weight percentage: arithoke is 55%, and Folium Ilicis is 35%, and Folium Sennae is 10%.
Embodiment 5
A kind of antihyperglycemic antisenescence medicinal composition, be made up of following component by weight percentage: arithoke is 60%, Folium Ilicis is 40%.
A kind of antihyperglycemic antisenescence medicinal composition of embodiment 1-embodiment 5 can after taking by weighing by weight percentage, be pulverized according to a conventional method, and mix homogeneously is made.
Embodiment 6
A kind of preparation method of antihyperglycemic antisenescence medicinal composition, comprise the steps: that (1) takes by weighing by weight percentage: arithoke is 50%, and Folium Ilicis is 40%, and Folium Sennae is 10%; (2) the arithoke extracting in water is 2 times, and each amount of water is 8 times of arithoke weight, and extraction time is 2 hours, and extracting solution filters, filtrate reclaim and when being concentrated into 80 ℃ relative density be 1.15, carry out spray drying, cynara scolymus extracts; Folium Ilicis extracting in water 2 times, each amount of water is 8 times of Folium Ilicis weight, and extraction time is 2 hours, and extracting solution filters, and relative density was 1.15 when filtrate was concentrated into 80 ℃, carried out spray drying, got Folum Ilicis extract; Garfields Tea is broken into fine powder; (3) cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously are made.
Embodiment 7
A kind of preparation method of antihyperglycemic antisenescence medicinal composition comprises the steps:
(1) take by weighing by weight percentage: arithoke is 55%, and Folium Ilicis is 35%, and Folium Sennae is 10%;
Step (2), (3) are with embodiment 6.
Embodiment 8
A kind of preparation method of antihyperglycemic antisenescence medicinal composition comprises the steps:
(2) take by weighing by weight percentage: arithoke is 60%, and Folium Ilicis is 40%, and Folium Sennae is 0%;
Step (2), (3) are with embodiment 6.
Embodiment 9
A kind of preparation method of antihyperglycemic antisenescence medicinal composition, comprise the steps: that (1) takes by weighing by weight percentage: arithoke is 30%, and Folium Ilicis is 50%, and Folium Sennae is 20%; (2) the arithoke extracting in water is 3 times, and each amount of water is 6 times of arithoke weight, and extraction time is 1 hour, and extracting solution filters, filtrate reclaim and when being concentrated into 80 ℃ relative density be 1.00, carry out spray drying, cynara scolymus extracts; Folium Ilicis extracting in water 3 times, each amount of water is 6 times of Folium Ilicis weight, and extraction time is 1 hour, and extracting solution filters, and relative density was 1.00 when filtrate was concentrated into 80 ℃, carried out spray drying, got Folum Ilicis extract; Garfields Tea is broken into fine powder; (3) cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously are made.
Embodiment 10
A kind of preparation method of antihyperglycemic antisenescence medicinal composition comprises the steps: that (1) takes by weighing following component by weight percentage: 70%, and Folium Ilicis is 25%, Folium Sennae is 5%; (2) the arithoke extracting in water is 1 time, and each amount of water is 12 times of arithoke weight, and extraction time is 3 hours, and extracting solution filters, filtrate reclaim and when being concentrated into 80 ℃ relative density be 1.20, carry out spray drying, cynara scolymus extracts; Folium Ilicis extracting in water 1 time, each amount of water is 12 times of Folium Ilicis weight, and extraction time is 3 hours, and extracting solution filters, and relative density was 1.20 when filtrate was concentrated into 80 ℃, carried out spray drying, got Folum Ilicis extract; Garfields Tea is broken into fine powder; (3) cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously are made.
Embodiment 11
A kind of preparation method of antihyperglycemic antisenescence medicinal composition comprises the steps: that (1) takes by weighing by weight percentage: arithoke 50%, Folium Ilicis 40%, Folium Sennae 10%; (2) the arithoke extracting in water is 2 times, and for the first time amount of water is 10 times of arithoke weight, extracts 2 hours, for the second time amount of water is 8 times of arithoke weight, extracts the extracting solution filtration 2 hours, relative density 1.00 when filtrate was concentrated into 80 ℃, carried out spray drying, got cynara scolymus extracts; Folium Ilicis extracting in water 2 times, for the first time amount of water is 10 times of Folium Ilicis weight, extracts 2 hours, for the second time amount of water is 8 times of Folium Ilicis weight, extracts the extracting solution filtration 2 hours, relative density 1.00-1.10 when filtrate is concentrated into 80 ℃ carries out spray drying, gets Folum Ilicis extract; Garfields Tea is broken into fine powder; (3) with cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously, add starch, make granule to 60% of arithoke weight, encapsulated, make bitter Ji capsule.
Embodiment 12
A kind of preparation method of antihyperglycemic antisenescence medicinal composition comprises the steps: that (1) takes by weighing by weight percentage: arithoke 55%, Folium Ilicis 35%, Folium Sennae 10%; (2), with embodiment 11; (3) with cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously, add starch, make granule to 50% of arithoke weight, encapsulated, make bitter Ji capsule.
Embodiment 13
A kind of preparation method of antihyperglycemic antisenescence medicinal composition comprises the steps: that (1) takes by weighing by weight percentage: arithoke 60%, Folium Ilicis 40%; (2), with embodiment 11; (3) with cynara scolymus extracts, Folum Ilicis extract mix homogeneously, add starch to 80% of arithoke weight, make granule, encapsulated, make bitter Ji capsule.
With the compositions of embodiment 1-5 and the compositions and acceptable accessories (as starch, dextrin, magnesium stearate, hydroxypropyl starch sodium, sodium carboxymethyl cellulose, carboxymethylcellulose calcium, lactose, the pregelatinized Starch etc.) mix homogeneously of embodiment 6-10 preparation, make granule, encapsulated, or be pressed into tablet.
Also can make pill, soft capsule, granule, slow releasing tablet, drop pill etc. according to a conventional method or make syrup or mixture etc.
Embodiment 14
Clinical research to a kind of antihyperglycemic antisenescence medicinal composition of the present invention (bitter Ji capsule).Method: divide 2 groups at random with 300 slight hyperlipidemia patients, the bitter Ji capsule of test group oral (embodiment 11 preparations), matched group oral placebo (making) by starch, the bitter Ji capsule of 16 all post-evaluations is to the influence of blood fat.The result: during off-test, test group serum total cholesterol (TC) on average reduces by 3.8%, and wherein 76% patients serum's T-CHOL (TC) reaches normal level, promptly is reduced to below the 5.2mmol/L (200mg/dl); Low-density lipoprotein cholesterol (LDL-C) on average reduces by 3.0%, and wherein 68% patient's low-density lipoprotein cholesterol (LDL-C) reaches normal level, promptly is reduced to below the 3.12mmol/L (120mg/dl), is starkly lower than matched group.It is stronger than placebo to prove that the T-CHOL effect falls in a kind of antihyperglycemic antisenescence medicinal composition of the present invention (bitter Ji capsule).
We follow the tracks of 200 slimmers, and they once took (bitter Ji capsule) continuously and more than 3 months, there is no bad reflection.Arithoke has and strengthens hepatic and renal function, cholesterol reducing, promotion amino acid metabolism, effect such as aid digestion in a kind of antihyperglycemic antisenescence medicinal composition of the present invention, can antioxidation, and delaying senility function.Folium Ilicis has effects such as pharynx-clearing throat-benefiting, heat-clearing and toxic substances removing, liver-protecting and alcoholism-relieving, antiinflammatory be convenient; Also hypertension, hyperlipidemia, arteriosclerosis, diabetes, obesity, colitis, constipation, hemorrhoid and all kinds of oral inflammations etc. there is tangible preventive and therapeutic effect; Be described as health tea, beauty treatment tea, blood-pressure decreasing tea and the tea that lengthens one's life.Folium Sennae can be rushed down down, blood fat reducing, fat-reducing.The three share and makes compositions of the present invention become green diet products; It also is good recipe good merchantable brand for the preparation of hyperlipemic patients amount body.
Embodiment 15
Clinical research to a kind of antihyperglycemic antisenescence medicinal composition of the present invention.Method: divide 2 groups at random with 300 slight hyperlipidemia patients, the bitter Ji capsule of test group oral (embodiment 12 preparations), matched group oral placebo (making) by starch, the bitter Ji capsule of 16 all post-evaluations is to the influence of blood fat.The result: during off-test, test group serum total cholesterol (TC) on average reduces by 4.0%, and wherein 78% patients serum's T-CHOL (TC) reaches normal level, promptly is reduced to below the 5.2mmol/L (200mg/dl); Low-density lipoprotein cholesterol (LDL-C) on average reduces by 3.1%, and wherein 70% patient's low-density lipoprotein cholesterol (LDL-C) reaches normal level, promptly is reduced to below the 3.12mmol/L (120mg/dl), is starkly lower than matched group.
Embodiment 16
Clinical research to a kind of antihyperglycemic antisenescence medicinal composition of the present invention.Method: divide 2 groups at random with 300 slight hyperlipidemia patients, the bitter Ji capsule of test group oral (embodiment 13 preparations), matched group oral placebo (making) by starch, the bitter Ji capsule of 16 all post-evaluations is to the influence of blood fat.The result: during off-test, test group serum total cholesterol (TC) on average reduces by 3.2%, and wherein 72% patients serum's T-CHOL (TC) reaches normal level, promptly is reduced to below the 5.2mmol/L (200mg/dl); Low-density lipoprotein cholesterol (LDL-C) on average reduces by 2.5%, and wherein 62% patient's low-density lipoprotein cholesterol (LDL-C) reaches normal level, promptly is reduced to below the 3.12mmol/L (120mg/dl), is starkly lower than matched group.
Embodiment 17
A kind of antihyperglycemic antisenescence medicinal composition (bitter Ji capsule) sense organ requirement
This product is a hard capsule, and content is light yellow granule to buff, bitter in the mouth, puckery.
Net content
Should meet labelled amount, its minus deviation should meet the regulation that State Administration for Quality Supervision and Inspection and Quarantine makes No. 75 " quantification packing commodity metrological supervision and administration way ".
Physical and chemical index
Every physical and chemical index sees Table 1
Table 1 physical and chemical index
| Project | Standard-required |
| Moisture %≤ | 9.0 |
| Ash %≤ | 18.0 |
| Total arsenic (in As)/(mg/kg)≤ | 2.0 |
| Plumbous (in Pb)/(mg/kg)≤ | 5.0 |
| Hydrargyrum (in Hg)/(mg/kg)≤ | 0.3 |
| The arithoke thin layer chromatography is differentiated | Should be positive |
Microbiological indicator
The regulation that should meet table 2 microbiological indicator
Table 2 microbiological indicator
| Project | Standard-required |
| Total plate count (cfu/g)≤ | 1000 |
| Coliform (MPN/100g)≤ | 40 |
| Mycete (cfu/g)≤ | 25 |
| Yeast (cfu/g)≤ | 25 |
| Pathogenic bacterium (Salmonella, shigella, staphylococcus aureus) | Must not detect |
Function cures mainly: cholesterol reducing, reduce athero, and improve gastrointestinal function, slow down aging.Can effectively reduce the accumulation of body fat, cholesterol reducing, prevention fatty liver increase the liver detoxification ability, significantly improve body immunity, help toxins in human body to discharge by intestinal; But and each organ aging's process of delaying human body, beautify skin.
Usage and dosage: oral.One time 2,2 times on the one.
Specification: every dress 0.5g.
Claims (8)
1. an antihyperglycemic antisenescence medicinal composition is characterized in that being made up of following component by weight percentage: arithoke 30%-70%, Folium Ilicis 25%-50%, Folium Sennae 0%-20%.
2. a kind of antihyperglycemic antisenescence medicinal composition according to claim 1 is characterized in that described arithoke is 50%, and Folium Ilicis is 40%, and Folium Sennae is 10%.
3. a kind of antihyperglycemic antisenescence medicinal composition according to claim 1 is characterized in that described arithoke is 55%, and Folium Ilicis is 35%, and Folium Sennae is 10%.
4. a kind of antihyperglycemic antisenescence medicinal composition according to claim 1 is characterized in that described arithoke is 60%, and Folium Ilicis is 40%.
5. the preparation method of an antihyperglycemic antisenescence medicinal composition, its feature comprises the steps: that (1) takes by weighing by weight percentage: arithoke 30%-70%, Folium Ilicis 25%-50%, Folium Sennae 0%-20%; (2) the arithoke extracting in water is 1-3 time, each amount of water be arithoke weight 6-12 doubly, extraction time is 1-3 hour, extracting solution filters, filtrate reclaim and when being concentrated into 80 ℃ relative density be 1.00-1.20, carry out spray drying, cynara scolymus extracts; Folium Ilicis extracting in water 1-3 time, each amount of water be Folium Ilicis weight 6-12 doubly, extraction time is 1-3 hour, extracting solution filters, relative density was 1.00-1.20 when filtrate was concentrated into 80 ℃, carried out spray drying, Folum Ilicis extract; Garfields Tea is broken into fine powder; (3) cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously are made.
6. the preparation method of a kind of antihyperglycemic antisenescence medicinal composition according to claim 5, it is characterized in that described step is: (1) takes by weighing by weight percentage: arithoke 50%, Folium Ilicis 40%, Folium Sennae 10%; (2) the arithoke extracting in water is 2 times, and for the first time amount of water is 10 times of arithoke weight, extracts 2 hours, for the second time amount of water is 8 times of arithoke weight, extracts the extracting solution filtration 2 hours, relative density 1.00-1.10 when filtrate is concentrated into 80 ℃ carries out spray drying, gets cynara scolymus extracts; Folium Ilicis extracting in water 2 times, for the first time amount of water is 10 times of Folium Ilicis weight, extracts 2 hours, for the second time amount of water is 8 times of Folium Ilicis weight, extracts the extracting solution filtration 2 hours, relative density 1.00-1.10 when filtrate is concentrated into 80 ℃ carries out spray drying, gets Folum Ilicis extract; Garfields Tea is broken into fine powder; (3) cynara scolymus extracts, Folum Ilicis extract, Folium Sennae fine powder mix homogeneously are made.
7. the preparation method of a kind of antihyperglycemic antisenescence medicinal composition according to claim 6 is characterized in that described arithoke is 55%, and Folium Ilicis is 35%, and Folium Sennae is 10%.
8. the preparation method of a kind of antihyperglycemic antisenescence medicinal composition according to claim 6 is characterized in that described arithoke is 60%, and Folium Ilicis is 40%, and Folium Sennae is 0%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710058960A CN100589814C (en) | 2007-08-17 | 2007-08-17 | Antihyperglycemic antisenescence medicinal composition and method for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710058960A CN100589814C (en) | 2007-08-17 | 2007-08-17 | Antihyperglycemic antisenescence medicinal composition and method for preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101116675A true CN101116675A (en) | 2008-02-06 |
| CN100589814C CN100589814C (en) | 2010-02-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200710058960A Expired - Fee Related CN100589814C (en) | 2007-08-17 | 2007-08-17 | Antihyperglycemic antisenescence medicinal composition and method for preparing the same |
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| Country | Link |
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| CN (1) | CN100589814C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107821973A (en) * | 2017-12-15 | 2018-03-23 | 柳州飞升鹏科技有限公司 | A kind of black soya bean cake of reducing blood lipid and preparation method thereof |
| CN107927779A (en) * | 2017-11-27 | 2018-04-20 | 爱可道生物科技有限公司 | A kind of beautifying face and moistering lotion oral liquid and preparation method thereof |
-
2007
- 2007-08-17 CN CN200710058960A patent/CN100589814C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107927779A (en) * | 2017-11-27 | 2018-04-20 | 爱可道生物科技有限公司 | A kind of beautifying face and moistering lotion oral liquid and preparation method thereof |
| CN107821973A (en) * | 2017-12-15 | 2018-03-23 | 柳州飞升鹏科技有限公司 | A kind of black soya bean cake of reducing blood lipid and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100589814C (en) | 2010-02-17 |
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Granted publication date: 20100217 Termination date: 20120817 |