CN1231208C - 药物组合物 - Google Patents

药物组合物 Download PDF

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Publication number
CN1231208C
CN1231208C CNB01807863XA CN01807863A CN1231208C CN 1231208 C CN1231208 C CN 1231208C CN B01807863X A CNB01807863X A CN B01807863XA CN 01807863 A CN01807863 A CN 01807863A CN 1231208 C CN1231208 C CN 1231208C
Authority
CN
China
Prior art keywords
composition
fatty acid
acid
composition according
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB01807863XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1422149A (zh
Inventor
M·安布西尔
B·翰贝尔林
B·勒克尔
A·迈纳
O·兰伯特
L·马夏尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1422149A publication Critical patent/CN1422149A/zh
Application granted granted Critical
Publication of CN1231208C publication Critical patent/CN1231208C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB01807863XA 2000-04-10 2001-04-09 药物组合物 Expired - Fee Related CN1231208C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0008785.8 2000-04-10
GBGB0008785.8A GB0008785D0 (en) 2000-04-10 2000-04-10 Organic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2005100643755A Division CN100431600C (zh) 2000-04-10 2001-04-09 药物组合物

Publications (2)

Publication Number Publication Date
CN1422149A CN1422149A (zh) 2003-06-04
CN1231208C true CN1231208C (zh) 2005-12-14

Family

ID=9889585

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB01807863XA Expired - Fee Related CN1231208C (zh) 2000-04-10 2001-04-09 药物组合物
CNB2005100643755A Expired - Fee Related CN100431600C (zh) 2000-04-10 2001-04-09 药物组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB2005100643755A Expired - Fee Related CN100431600C (zh) 2000-04-10 2001-04-09 药物组合物

Country Status (12)

Country Link
US (3) US20030133984A1 (https=)
EP (2) EP1767193A3 (https=)
JP (1) JP2003530340A (https=)
CN (2) CN1231208C (https=)
AU (1) AU2001250420A1 (https=)
BR (1) BR0109931A (https=)
CA (1) CA2404368C (https=)
FR (1) FR2807658A1 (https=)
GB (1) GB0008785D0 (https=)
IT (1) ITMI20010748A1 (https=)
PE (1) PE20020225A1 (https=)
WO (1) WO2001076561A2 (https=)

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US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
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GB2391471B (en) * 2002-08-02 2005-05-04 Satishchandra Punambhai Patel Pharmaceutical compositions
GB0218996D0 (en) * 2002-08-14 2002-09-25 Novartis Ag Organic compounds
AU2003205543A1 (en) * 2003-01-14 2004-08-10 Lifecycle Pharma A/S Dry dispersions
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
CN1829514A (zh) * 2003-07-25 2006-09-06 惠氏公司 Cci－779冻干制剂
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
GB0504950D0 (en) * 2005-03-10 2005-04-20 Novartis Ag Organic compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
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US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
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US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
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WO2008109163A1 (en) * 2007-03-07 2008-09-12 Abraxis Bioscience, Llc. Nanoparticle comprising rapamycin and albumin as anticancer agent
CN101199836B (zh) * 2007-11-07 2011-03-30 安徽省药物研究所 一种阶段释放型环孢素a固体微乳制剂及其微乳固化方法
CU23892B1 (es) * 2007-12-07 2013-04-19 Ct De Investigación Y Desarrollo De Medicamentos Cidem Composición farmacéutica microencapsulada de ciclosporina a
CN102223875A (zh) * 2008-11-21 2011-10-19 贝林格尔.英格海姆国际有限公司 口服给药的强效hcv抑制剂的药物组合物
JP5607736B2 (ja) 2009-07-07 2014-10-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃ型肝炎ウイルスプロテアーゼ阻害剤のための医薬組成物
US20110105387A1 (en) * 2009-09-19 2011-05-05 Nian Wu Method of treatment with rapamycin
EA027666B1 (ru) 2010-05-03 2017-08-31 ТЕИКОКУ ФАРМА ЮСЭй, ИНК. Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
TW201503912A (zh) * 2013-03-19 2015-02-01 Novartis Ag 包含癌莫事（ｅｖｅｒｏｌｉｍｕｓ）之醫藥組合物
HK1245095A1 (zh) 2015-05-20 2018-08-24 Novartis Ag 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合
ITUA20164228A1 (it) * 2016-06-09 2017-12-09 Labomar S R L Formulazione a matrice grassa auto-emulsionante e gastro-resistente e relativo metodo di preparazione
CN110114070A (zh) 2016-11-23 2019-08-09 诺华公司 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法
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Also Published As

Publication number Publication date
EP1272163A2 (en) 2003-01-08
CN100431600C (zh) 2008-11-12
AU2001250420A1 (en) 2001-10-23
US20030133984A1 (en) 2003-07-17
ITMI20010748A1 (it) 2002-10-06
US20060134203A1 (en) 2006-06-22
CA2404368A1 (en) 2001-10-18
FR2807658A1 (fr) 2001-10-19
ITMI20010748A0 (it) 2001-04-06
CN1422149A (zh) 2003-06-04
JP2003530340A (ja) 2003-10-14
CN1679916A (zh) 2005-10-12
PE20020225A1 (es) 2002-04-15
EP1767193A3 (en) 2009-01-28
CA2404368C (en) 2011-02-01
BR0109931A (pt) 2003-05-27
WO2001076561A3 (en) 2002-02-21
GB0008785D0 (en) 2000-05-31
EP1767193A2 (en) 2007-03-28
US20100215734A1 (en) 2010-08-26
WO2001076561A2 (en) 2001-10-18

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20051214

Termination date: 20120409