JP2003530340A - 医薬組成物 - Google Patents
医薬組成物Info
- Publication number
- JP2003530340A JP2003530340A JP2001574079A JP2001574079A JP2003530340A JP 2003530340 A JP2003530340 A JP 2003530340A JP 2001574079 A JP2001574079 A JP 2001574079A JP 2001574079 A JP2001574079 A JP 2001574079A JP 2003530340 A JP2003530340 A JP 2003530340A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- acid
- surfactant
- composition according
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000004094 surface-active agent Substances 0.000 claims abstract description 42
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- 108010036949 Cyclosporine Proteins 0.000 claims abstract description 26
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- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 9
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- ZDQSOHOQTUFQEM-PKUCKEGBSA-N ascomycin Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](O)[C@H](OC)C1 ZDQSOHOQTUFQEM-PKUCKEGBSA-N 0.000 description 8
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- OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 6
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- FMMOOAYVCKXGMF-UHFFFAOYSA-N linoleic acid ethyl ester Natural products CCCCCC=CCC=CCCCCCCCC(=O)OCC FMMOOAYVCKXGMF-UHFFFAOYSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
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- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 238000010587 phase diagram Methods 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
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- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-N sodium;dodecyl sulfate;hydron Chemical compound [H+].[Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-N 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229940032091 stigmasterol Drugs 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
- 235000016831 stigmasterol Nutrition 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
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- 239000011732 tocopherol Substances 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
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- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 125000001020 α-tocopherol group Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0008785.8 | 2000-04-10 | ||
| GBGB0008785.8A GB0008785D0 (en) | 2000-04-10 | 2000-04-10 | Organic compounds |
| PCT/EP2001/004051 WO2001076561A2 (en) | 2000-04-10 | 2001-04-09 | Pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003530340A true JP2003530340A (ja) | 2003-10-14 |
| JP2003530340A5 JP2003530340A5 (https=) | 2008-05-22 |
Family
ID=9889585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001574079A Pending JP2003530340A (ja) | 2000-04-10 | 2001-04-09 | 医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20030133984A1 (https=) |
| EP (2) | EP1767193A3 (https=) |
| JP (1) | JP2003530340A (https=) |
| CN (2) | CN1231208C (https=) |
| AU (1) | AU2001250420A1 (https=) |
| BR (1) | BR0109931A (https=) |
| CA (1) | CA2404368C (https=) |
| FR (1) | FR2807658A1 (https=) |
| GB (1) | GB0008785D0 (https=) |
| IT (1) | ITMI20010748A1 (https=) |
| PE (1) | PE20020225A1 (https=) |
| WO (1) | WO2001076561A2 (https=) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008532967A (ja) * | 2005-03-10 | 2008-08-21 | ノバルティス アクチエンゲゼルシャフト | カンナビノイド受容体結合化合物のマイクロエマルジョン |
| JP2014015487A (ja) * | 2007-03-07 | 2014-01-30 | Abraxis Bioscience Llc | 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子 |
| JP2016515543A (ja) * | 2013-03-19 | 2016-05-30 | ノバルティス アーゲー | エベロリムスを含む医薬組成物 |
| US10441584B2 (en) | 2016-11-23 | 2019-10-15 | Novartis Ag | Methods of enhancing immune response |
| US10576076B2 (en) | 2015-05-20 | 2020-03-03 | Novartis Ag | Pharmaceutical combination of everolimus with dactolisib |
| US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
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| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
| AR033711A1 (es) * | 2001-05-09 | 2004-01-07 | Novartis Ag | Composiciones farmaceuticas |
| GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| JP4387639B2 (ja) * | 2002-07-16 | 2009-12-16 | 久光製薬株式会社 | 経皮吸収製剤 |
| GB2391471B (en) * | 2002-08-02 | 2005-05-04 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
| GB0218996D0 (en) * | 2002-08-14 | 2002-09-25 | Novartis Ag | Organic compounds |
| AU2003205543A1 (en) * | 2003-01-14 | 2004-08-10 | Lifecycle Pharma A/S | Dry dispersions |
| US20040185068A1 (en) * | 2003-03-18 | 2004-09-23 | Zhi-Jian Yu | Self-emulsifying compositions, methods of use and preparation |
| CN1829514A (zh) * | 2003-07-25 | 2006-09-06 | 惠氏公司 | Cci－779冻干制剂 |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US7276476B2 (en) * | 2005-07-13 | 2007-10-02 | Allergan, Inc. | Cyclosporin compositions |
| US7288520B2 (en) * | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
| US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| US7297679B2 (en) * | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
| US7202209B2 (en) | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
| US20070015693A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| US7501393B2 (en) | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| US7745400B2 (en) * | 2005-10-14 | 2010-06-29 | Gregg Feinerman | Prevention and treatment of ocular side effects with a cyclosporin |
| US9839667B2 (en) | 2005-10-14 | 2017-12-12 | Allergan, Inc. | Prevention and treatment of ocular side effects with a cyclosporin |
| EP1880715A1 (en) * | 2006-07-19 | 2008-01-23 | Abbott GmbH & Co. KG | Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same |
| CN101199836B (zh) * | 2007-11-07 | 2011-03-30 | 安徽省药物研究所 | 一种阶段释放型环孢素a固体微乳制剂及其微乳固化方法 |
| CU23892B1 (es) * | 2007-12-07 | 2013-04-19 | Ct De Investigación Y Desarrollo De Medicamentos Cidem | Composición farmacéutica microencapsulada de ciclosporina a |
| CN102223875A (zh) * | 2008-11-21 | 2011-10-19 | 贝林格尔.英格海姆国际有限公司 | 口服给药的强效hcv抑制剂的药物组合物 |
| JP5607736B2 (ja) | 2009-07-07 | 2014-10-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃ型肝炎ウイルスプロテアーゼ阻害剤のための医薬組成物 |
| US20110105387A1 (en) * | 2009-09-19 | 2011-05-05 | Nian Wu | Method of treatment with rapamycin |
| EA027666B1 (ru) | 2010-05-03 | 2017-08-31 | ТЕИКОКУ ФАРМА ЮСЭй, ИНК. | Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| ITUA20164228A1 (it) * | 2016-06-09 | 2017-12-09 | Labomar S R L | Formulazione a matrice grassa auto-emulsionante e gastro-resistente e relativo metodo di preparazione |
| WO2025153584A1 (en) * | 2024-01-17 | 2025-07-24 | Basf Se | Solid self-emulsifying dosage form |
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-
2000
- 2000-04-10 GB GBGB0008785.8A patent/GB0008785D0/en not_active Ceased
-
2001
- 2001-04-06 IT IT2001MI000748A patent/ITMI20010748A1/it unknown
- 2001-04-06 FR FR0104713A patent/FR2807658A1/fr not_active Withdrawn
- 2001-04-06 PE PE2001000321A patent/PE20020225A1/es not_active Application Discontinuation
- 2001-04-09 CA CA2404368A patent/CA2404368C/en not_active Expired - Fee Related
- 2001-04-09 AU AU2001250420A patent/AU2001250420A1/en not_active Abandoned
- 2001-04-09 JP JP2001574079A patent/JP2003530340A/ja active Pending
- 2001-04-09 US US10/239,456 patent/US20030133984A1/en not_active Abandoned
- 2001-04-09 EP EP06120628A patent/EP1767193A3/en not_active Withdrawn
- 2001-04-09 EP EP01923719A patent/EP1272163A2/en not_active Ceased
- 2001-04-09 BR BR0109931-0A patent/BR0109931A/pt not_active Application Discontinuation
- 2001-04-09 CN CNB01807863XA patent/CN1231208C/zh not_active Expired - Fee Related
- 2001-04-09 WO PCT/EP2001/004051 patent/WO2001076561A2/en not_active Ceased
- 2001-04-09 CN CNB2005100643755A patent/CN100431600C/zh not_active Expired - Fee Related
-
2005
- 2005-12-14 US US11/300,575 patent/US20060134203A1/en not_active Abandoned
-
2010
- 2010-05-05 US US12/774,452 patent/US20100215734A1/en not_active Abandoned
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| EP0556394B1 (en) * | 1990-11-06 | 2002-06-19 | Nippon Shinyaku Company, Limited | Lyophilized preparation and production thereof |
| WO1995022982A1 (en) * | 1994-02-25 | 1995-08-31 | Chong Kun Dang Corp. | Cyclosporin-containing powder composition |
| WO1995032726A1 (en) * | 1994-06-01 | 1995-12-07 | Yuhan Corporation | Cyclosporin containing composition and process for the preparation thereof |
| WO1999027946A1 (en) * | 1997-12-02 | 1999-06-10 | Chong Kun Dang Corp. | Pharmaceutical composition comprising cyclosporin solid-state microemulsion |
| DE19819273A1 (de) * | 1998-04-30 | 1999-11-11 | Pharmatec International S Giul | Pharmazeutische Ciclosporin-Formulierung mit verbesserten biopharmazeutischen Eigenschaften, erhöhter physikalischer Qualität und Stabilität sowie Verfahren zur Herstellung |
| WO2000000179A1 (en) * | 1998-06-27 | 2000-01-06 | Won Jin Biopharma Co., Ltd. | Solid dispersed preparation of poorly water-soluble drug containing oil, fatty acid or mixtures thereof |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008532967A (ja) * | 2005-03-10 | 2008-08-21 | ノバルティス アクチエンゲゼルシャフト | カンナビノイド受容体結合化合物のマイクロエマルジョン |
| JP2014015487A (ja) * | 2007-03-07 | 2014-01-30 | Abraxis Bioscience Llc | 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子 |
| JP2017132810A (ja) * | 2007-03-07 | 2017-08-03 | アブラクシス バイオサイエンス， エルエルシー | 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子 |
| JP2018150381A (ja) * | 2007-03-07 | 2018-09-27 | アブラクシス バイオサイエンス， エルエルシー | 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子 |
| JP2016515543A (ja) * | 2013-03-19 | 2016-05-30 | ノバルティス アーゲー | エベロリムスを含む医薬組成物 |
| US10576076B2 (en) | 2015-05-20 | 2020-03-03 | Novartis Ag | Pharmaceutical combination of everolimus with dactolisib |
| US10441584B2 (en) | 2016-11-23 | 2019-10-15 | Novartis Ag | Methods of enhancing immune response |
| US10993940B2 (en) | 2016-11-23 | 2021-05-04 | Novartis Ag | Methods of enhancing immune response |
| US11045463B2 (en) | 2016-11-23 | 2021-06-29 | Novartis Ag | Methods of enhancing immune response |
| US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1272163A2 (en) | 2003-01-08 |
| CN100431600C (zh) | 2008-11-12 |
| AU2001250420A1 (en) | 2001-10-23 |
| US20030133984A1 (en) | 2003-07-17 |
| ITMI20010748A1 (it) | 2002-10-06 |
| US20060134203A1 (en) | 2006-06-22 |
| CA2404368A1 (en) | 2001-10-18 |
| FR2807658A1 (fr) | 2001-10-19 |
| ITMI20010748A0 (it) | 2001-04-06 |
| CN1231208C (zh) | 2005-12-14 |
| CN1422149A (zh) | 2003-06-04 |
| CN1679916A (zh) | 2005-10-12 |
| PE20020225A1 (es) | 2002-04-15 |
| EP1767193A3 (en) | 2009-01-28 |
| CA2404368C (en) | 2011-02-01 |
| BR0109931A (pt) | 2003-05-27 |
| WO2001076561A3 (en) | 2002-02-21 |
| GB0008785D0 (en) | 2000-05-31 |
| EP1767193A2 (en) | 2007-03-28 |
| US20100215734A1 (en) | 2010-08-26 |
| WO2001076561A2 (en) | 2001-10-18 |
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