CN1227211C - 一种回收抗生素生产过程中的醋酸丁酯的方法 - Google Patents
一种回收抗生素生产过程中的醋酸丁酯的方法 Download PDFInfo
- Publication number
- CN1227211C CN1227211C CNB031214088A CN03121408A CN1227211C CN 1227211 C CN1227211 C CN 1227211C CN B031214088 A CNB031214088 A CN B031214088A CN 03121408 A CN03121408 A CN 03121408A CN 1227211 C CN1227211 C CN 1227211C
- Authority
- CN
- China
- Prior art keywords
- butyl acetate
- production
- antibiotics
- resin
- resin column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 title claims abstract description 179
- 238000000034 method Methods 0.000 title claims abstract description 63
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 32
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 title abstract 5
- 230000003115 biocidal effect Effects 0.000 title description 7
- 229940043232 butyl acetate Drugs 0.000 title 1
- 239000011347 resin Substances 0.000 claims abstract description 65
- 229920005989 resin Polymers 0.000 claims abstract description 65
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 22
- 229940088710 antibiotic agent Drugs 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 238000011084 recovery Methods 0.000 claims abstract description 22
- 239000007864 aqueous solution Substances 0.000 claims abstract description 9
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 7
- 238000001179 sorption measurement Methods 0.000 claims abstract description 5
- 238000009833 condensation Methods 0.000 claims abstract description 4
- 230000005494 condensation Effects 0.000 claims abstract description 4
- 239000002351 wastewater Substances 0.000 claims description 26
- 238000010521 absorption reaction Methods 0.000 claims description 7
- 150000001993 dienes Chemical class 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 5
- 229930195729 fatty acid Natural products 0.000 claims description 5
- 239000000194 fatty acid Substances 0.000 claims description 5
- -1 fatty acid ester Chemical class 0.000 claims description 5
- 230000003068 static effect Effects 0.000 claims description 5
- 239000003463 adsorbent Substances 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 3
- 239000012452 mother liquor Substances 0.000 claims description 2
- 230000000274 adsorptive effect Effects 0.000 claims 1
- 238000004821 distillation Methods 0.000 abstract description 7
- 229920000642 polymer Polymers 0.000 abstract description 3
- 102000004169 proteins and genes Human genes 0.000 abstract description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 3
- 238000004925 denaturation Methods 0.000 abstract description 2
- 230000036425 denaturation Effects 0.000 abstract description 2
- 238000005191 phase separation Methods 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 19
- 229930182555 Penicillin Natural products 0.000 description 11
- 229940049954 penicillin Drugs 0.000 description 11
- 239000012071 phase Substances 0.000 description 10
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- 239000002699 waste material Substances 0.000 description 6
- 238000001816 cooling Methods 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 4
- 229960003276 erythromycin Drugs 0.000 description 4
- 229940056360 penicillin g Drugs 0.000 description 4
- 229940056367 penicillin v Drugs 0.000 description 4
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 4
- 238000002479 acid--base titration Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 238000002386 leaching Methods 0.000 description 3
- 238000012797 qualification Methods 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 description 2
- 238000000197 pyrolysis Methods 0.000 description 2
- 239000010865 sewage Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 150000003952 β-lactams Chemical class 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- OAIYNRAQCIOEBD-UHFFFAOYSA-N butyl acetate;hydrate Chemical compound O.CCCCOC(C)=O OAIYNRAQCIOEBD-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
- 239000002132 β-lactam antibiotic Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031214088A CN1227211C (zh) | 2003-03-28 | 2003-03-28 | 一种回收抗生素生产过程中的醋酸丁酯的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031214088A CN1227211C (zh) | 2003-03-28 | 2003-03-28 | 一种回收抗生素生产过程中的醋酸丁酯的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1534012A CN1534012A (zh) | 2004-10-06 |
CN1227211C true CN1227211C (zh) | 2005-11-16 |
Family
ID=34285693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB031214088A Expired - Fee Related CN1227211C (zh) | 2003-03-28 | 2003-03-28 | 一种回收抗生素生产过程中的醋酸丁酯的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1227211C (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1304358C (zh) * | 2005-04-22 | 2007-03-14 | 清华大学 | 一种液相吸附制取高纯醋酸甲酯的方法 |
CN101575288B (zh) * | 2009-06-18 | 2012-04-04 | 孙宗长 | 一种从含乙酸乙酯废水中回收乙酸乙酯的方法 |
CN113230830B (zh) * | 2021-04-14 | 2023-05-02 | 内蒙古常盛制药有限公司 | 一种含醋酸丁酯工业废气的处理方法 |
CN114380352B (zh) * | 2022-01-26 | 2023-10-13 | 山东微研生物科技有限公司 | 一种β-胡萝卜素提取废水中乙酸乙酯的回收装置及回收方法 |
-
2003
- 2003-03-28 CN CNB031214088A patent/CN1227211C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1534012A (zh) | 2004-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5185481A (en) | Method for the separation of impurities from crude ethanol aqueous solution | |
CN101811965B (zh) | 共沸精馏分离回收废水中的醋酸丁酯和丁醇的工艺 | |
US20070025976A1 (en) | Process for the purification of coenzyme Q10 | |
KR20100130219A (ko) | 3급 아미드 용매로부터 산을 제거하는 방법 | |
US20120215026A1 (en) | Recovery of volatile carboxylic acids by extractive evaporation | |
CN100390082C (zh) | 一种间苯二甲酸二甲酯-5-磺酸生产废水的治理及资源化方法 | |
CN102432453A (zh) | 稀醋酸溶液提纯工艺及设备 | |
CN108659061B (zh) | 一种三氯蔗糖结晶母液的提纯处理方法 | |
CN101348428B (zh) | 一种阴离子树脂吸附提取发酵液中丁二酸的方法 | |
JPH04228084A (ja) | クエン酸の回収方法 | |
CN1227211C (zh) | 一种回收抗生素生产过程中的醋酸丁酯的方法 | |
CN101074258A (zh) | 一种从大豆脱臭馏出物中分离提取植物甾醇和维生素e的方法 | |
CN1156407C (zh) | 4,4'-二硝基二苯乙烯-2,2'-二磺酸生产废水的治理与资源化 | |
CN112679011B (zh) | 一种含edot电化学废水处理及资源回收利用的方法 | |
CN1313282A (zh) | 糠醛废水治理及回收糠醛和醋酸工艺 | |
CN1865223A (zh) | 从邻苯二胺生产废水中提取邻苯二胺的方法 | |
CN110922320B (zh) | 一种甲基异丁基甲酮和对甲苯磺酸钠的提取方法 | |
CN1233570C (zh) | 硝基氯苯生产废水中硝基氯苯的树脂吸附回收工艺 | |
CN102952008A (zh) | 一种从厌氧发酵液中提取丁二酸的方法 | |
CN101898935A (zh) | 从发酵液中萃取分离1,3-丙二醇的方法 | |
US4691055A (en) | Concentration of organic chemicals from dilute aqueous solutions | |
CN1923845A (zh) | 高含量大豆皂苷的制备方法 | |
CN115445242B (zh) | 一种达格列净中间体母液的处理装置和方法 | |
CN219423753U (zh) | 一种从低处理量含氨废水中回收乙腈的精馏装置 | |
CN1170797C (zh) | β-苯乙醇的提纯方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: NCPC Hebei Huamin Pharma Co., Ltd. Assignor: Huabei Pharmaceutical Group Co., Ltd. Contract record no.: 2010130000112 Denomination of invention: Method recovering butylacetate in antibiotic production process Granted publication date: 20051116 License type: Exclusive License Open date: 20041006 Record date: 20101118 |
|
ASS | Succession or assignment of patent right |
Owner name: NCPC HEBEI HUAMIN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HUABEI PHARMACEUTICAL GROUP CO., LTD. Effective date: 20140916 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 050015 SHIJIAZHUANG, HEBEI PROVINCE TO: 052165 SHIJIAZHUANG, HEBEI PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140916 Address after: 052165, No. 98, Hainan Road, Hebei economic and Technological Development Zone, Shijiazhuang Patentee after: NCPC Hebei Huamin Pharma Co., Ltd. Address before: 050015 Heping East Road, Hebei, Shijiazhuang, No. 388 Patentee before: Huabei Pharmaceutical Group Co., Ltd. |
|
TR01 | Transfer of patent right |
Effective date of registration: 20190214 Address after: 050000 No. 388 Heping East Road, Shijiazhuang City, Hebei Province Patentee after: Huabei Pharmaceutical Co., Ltd. Address before: 052165 No. 98 Hainan Road, Liangcun Economic and Technological Development Zone, Shijiazhuang City, Hebei Province Patentee before: NCPC Hebei Huamin Pharma Co., Ltd. |
|
TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20051116 Termination date: 20200328 |
|
CF01 | Termination of patent right due to non-payment of annual fee |