CN1225682A - 通过调节转录因子活性调节t细胞亚群 - Google Patents

通过调节转录因子活性调节t细胞亚群 Download PDF

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CN1225682A
CN1225682A CN97195740A CN97195740A CN1225682A CN 1225682 A CN1225682 A CN 1225682A CN 97195740 A CN97195740 A CN 97195740A CN 97195740 A CN97195740 A CN 97195740A CN 1225682 A CN1225682 A CN 1225682A
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China
Prior art keywords
cell
nip45
maf
transcription factor
family protein
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Pending
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CN97195740A
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English (en)
Chinese (zh)
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L·H·格里姆彻尔
M·R·霍德格
I·C·霍
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Harvard College
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Harvard College
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Priority claimed from US08/636,602 external-priority patent/US5958671A/en
Priority claimed from US08/755,592 external-priority patent/US6537810B1/en
Priority claimed from US08/755,584 external-priority patent/US5858711A/en
Application filed by Harvard College filed Critical Harvard College
Publication of CN1225682A publication Critical patent/CN1225682A/zh
Pending legal-status Critical Current

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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Urology & Nephrology (AREA)
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CN97195740A 1996-04-23 1997-04-23 通过调节转录因子活性调节t细胞亚群 Pending CN1225682A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/636,602 1996-04-23
US08/636,602 US5958671A (en) 1996-04-23 1996-04-23 Methods and compositions for regulating T cell subsets by modulating transcription factor activity
US08/755,592 US6537810B1 (en) 1996-04-23 1996-11-25 Methods for regulating T cell subsets by modulating transcription factor activity
US08/755,584 1996-11-25
US08/755,592 1996-11-25
US08/755,584 US5858711A (en) 1996-11-25 1996-11-25 NF-AT-interacting protein NIP45 and methods of use therefor

Publications (1)

Publication Number Publication Date
CN1225682A true CN1225682A (zh) 1999-08-11

Family

ID=27417596

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97195740A Pending CN1225682A (zh) 1996-04-23 1997-04-23 通过调节转录因子活性调节t细胞亚群

Country Status (8)

Country Link
EP (1) EP0891425A2 (ko)
JP (1) JP2000510333A (ko)
KR (1) KR20000010606A (ko)
CN (1) CN1225682A (ko)
AU (1) AU720455B2 (ko)
CA (1) CA2252643A1 (ko)
NZ (1) NZ332897A (ko)
WO (1) WO1997039721A2 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722388D0 (en) * 1997-10-24 1997-12-24 Zeneca Ltd NIP45 human homolog
US6274338B1 (en) * 1998-02-24 2001-08-14 President And Fellows Of Harvard College Human c-Maf compositions and methods of use thereof
US6548734B1 (en) 1998-05-28 2003-04-15 President And Fellows Of Harvard College Methods relating to modulation of cartilage cell growth and/or differentiation by modulation of NFATp activity
MXPA02006433A (es) 1999-12-30 2002-11-29 Harvard College Metodos y composiciones que se refieren a la modulacion del crecimiento de hepatocitos, diferenciacion de celulas plasmaticas o actividad de subgrupos de celulas t mediante la modulacion de la actividad de xbp-1.
EP1259592A1 (en) * 2000-01-11 2002-11-27 Maxygen, Inc. Monocyte-derived dendritic cell subsets
ES2272471T3 (es) * 2000-04-25 2007-05-01 Bayer Healthcare Ag Regulacion de una variante de la proteina nip45 que interacciona con nf-at.
AU2001290316A1 (en) * 2000-10-02 2002-04-15 Mochida Pharmaceutical Co., Ltd. Gata-3 expression inhibitor and method of screening the same
EP2135611A1 (en) 2001-03-01 2009-12-23 Hollis-Eden Pharmaceuticals Inc. Pregn-5-en-20-yne-3,7,17-triol derivatives for use in therapy
US20050079496A1 (en) * 2001-08-17 2005-04-14 Edgar Serfling Methods for diagnosing and treating neoplasias using nf-at transcriptions factors
IL147138A0 (en) 2001-12-17 2002-08-14 Yeda Res & Dev Methods of and pharmaceutical compositions for modulating cell adhesion, migration and extravasation
US20090221024A1 (en) * 2006-03-02 2009-09-03 Antitope Limited T cell assays
US8227184B2 (en) 2008-01-14 2012-07-24 President And Fellows Of Harvard College Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity
KR101146335B1 (ko) * 2009-10-12 2012-05-21 한국원자력의학원 알파태아단백 인헨서 및 프로모터의 조절을 받아 리포터 단백질을 발현하는 형질 전환 마우스, 그의 제조 방법 및 이를 이용한 알파태아단백 발현의 증가 또는 감소 유도 물질을 스크리닝하는 방법
WO2012109238A2 (en) 2011-02-07 2012-08-16 President And Fellows Of Harvard College Methods for increasing immune responses using agents that directly bind to and activate ire-1
US20150018406A1 (en) 2012-03-09 2015-01-15 Cornell University Modulation of breast cancer growth by modulation of xbp1 activity
WO2015019125A1 (en) 2013-08-05 2015-02-12 Societe De Developpement Et De Recherche Industrielle Molecular targets for the treatment of wounds, in particular chronic wounds
EP3521431A1 (en) 2013-09-25 2019-08-07 Cornell University Compounds for inducing anti-tumor immunity and methods thereof

Also Published As

Publication number Publication date
WO1997039721A3 (en) 1998-04-09
JP2000510333A (ja) 2000-08-15
CA2252643A1 (en) 1997-10-30
AU720455B2 (en) 2000-06-01
WO1997039721A2 (en) 1997-10-30
NZ332897A (en) 2000-04-28
EP0891425A2 (en) 1999-01-20
AU3115597A (en) 1997-11-12
KR20000010606A (ko) 2000-02-15

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