CN1223119A - Traditional Chinese medicinal preparation for curing gynecopathy - Google Patents
Traditional Chinese medicinal preparation for curing gynecopathy Download PDFInfo
- Publication number
- CN1223119A CN1223119A CN97120991A CN97120991A CN1223119A CN 1223119 A CN1223119 A CN 1223119A CN 97120991 A CN97120991 A CN 97120991A CN 97120991 A CN97120991 A CN 97120991A CN 1223119 A CN1223119 A CN 1223119A
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- CN
- China
- Prior art keywords
- radix
- root
- rhizoma
- chinese medicinal
- curcumae
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- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 17
- 241000218176 Corydalis Species 0.000 claims abstract description 7
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 7
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 238000009472 formulation Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- 208000005171 Dysmenorrhea Diseases 0.000 abstract description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract description 2
- 230000002175 menstrual effect Effects 0.000 abstract description 2
- 241000427159 Achyranthes Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000202726 Bupleurum Species 0.000 abstract 1
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 240000009138 Curcuma zedoaria Species 0.000 abstract 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 206010021928 Infertility female Diseases 0.000 abstract 1
- 208000037093 Menstruation Disturbances Diseases 0.000 abstract 1
- 206010027339 Menstruation irregular Diseases 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 241000233932 Sparganium Species 0.000 abstract 1
- 241000301400 Trogopterus Species 0.000 abstract 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000003608 fece Anatomy 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 235000019509 white turmeric Nutrition 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- 201000009273 Endometriosis Diseases 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 230000004087 circulation Effects 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 208000007415 Anhedonia Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 241000237636 Pheretima Species 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- -1 extractum Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides an oral Chinese medicine preparation for curing the diseases of dysmenorrhea, irregular menstruation, menstrual molimen and female sterility, etc. Its raw material composition includes the Chinese medicinal materials of red sage root, zedoary, bupleurum root, red peony root, Chinese angelica root, burreed tuber, nutgrass flatsedge rhizome, corydalis tuber, trogopterus dung, achyranthes root, curcuma root, licorice and notoginseng. The tests show that its total effective rate is 92.5%, in which cure rate is 22.3%, effectual rate is 35.8%, and it has no toxic side effect.
Description
The present invention relates to a kind of Chinese medicine preparation that is used for the treatment of endometriosis.
Chinese patent application CN1123178A (application number 95111058.6) discloses " a kind of treatment endometriosis Chinese medicine preparation, preparation and processing technology ", and it mainly is made up of Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, Herba Artemisiae Annuae, the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae.
Chinese patent application CN1081107A (application number 93110326.6) discloses a kind of " medicine for endometriosis and manufacturing process thereof ", is to adopt Rhizoma Cyperi, Rhizoma Corydalis, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, rhizoma sparganic, Rhizoma Curcumae to make.Above-mentioned two kinds of medicines all are mainly to treat endometriosis, but the former prescription is based on Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, and the latter also has only 6 flavor medicines, and whole prescription seems thin, acts on incomplete.
Purpose of the present invention aims to provide a kind of pure Chinese medicinal preparation for the treatment of endometriosis.
Gynecopathy Chinese medicine preparation composition of the present invention is: Radix Salviae Miltiorrhizae 10-45g, Rhizoma Curcumae 8-20g, Radix Bupleuri 10-20g, Radix Paeoniae Rubra 10-20g, Radix Angelicae Sinensis 10-30g, rhizoma sparganic 6-20g, Rhizoma Cyperi 6-15g, Rhizoma Corydalis 6-15g, Oletum Trogopterori 6-20g, Radix Achyranthis Bidentatae 10-30g, Radix Curcumae 10-30g, Radix Glycyrrhizae 4-20g, Radix Notoginseng 3-30g make oral formulations.
Among the above-mentioned side, the Radix Salviae Miltiorrhizae hardship is slightly cold, and goes into the conscience warp, the promoting the circulation of blood stasis of blood, menstruction regulating and pain relieving; The Radix Paeoniae Rubra nature and flavor are bitter, cool, go into the liver spleen channel, clots absorbing, pain relieving, removing heat from blood, detumescence; The cold that is slightly cold of Radix Bupleuri hardship is gone into the liver and gall warp, reconciling superficies and interior, soothing liver-QI, resolving depression regulating menstruation; The Radix Curcumae toil is sweet cold, goes into the cardiopulmonary Liver Channel, removing heat from blood removing blood stasis with potent drugs, promoting QI circulation for relieving depression, promoting blood circulation and stopping pain; Rhizoma Curcumae toil temperature is gone into Liver Channel, the circulation of qi promoting removing blood stasis, and eliminate indigestion disappears, pain relieving; Rhizoma sparganic is arduous, goes into the liver spleen channel, the circulation of qi promoting removing blood stasis, and the removing food stagnancy pain relieving is stimulated the menstrual flow; Radix Glycyrrhizae property is sweet flat, goes into the taste lung meridian, invigorating middle warmer emergency, detoxifcation is arranged, the effect of coordinating the actions of various ingredients in a prescription.Radix Paeoniae Rubra can replace with Radix Paeoniae Alba 10-20g in the side, and Radix Angelicae Sinensis can replace with Rhizoma Chuanxiong 10-15g, and Rhizoma Cyperi can replace with Radix Aucklandiae 6-15g, and Oletum Trogopterori can replace with Pollen Typhae 10-15g, and Rhizoma Corydalis can replace with Olibanum 10-15g, and rhizoma sparganic can replace with Pheretima 10-20g.
Principal agent is gone into Liver Channel in the prescription of the present invention, and the effect of QI and blood regulating is arranged, and the medicine that has is double goes into kidney channel, nurses one's health congenitally, and some medicines are double goes into spleen channel, conditioning day after tomorrow.Full presciption medicine is neither cold and cool, and also partial heat not focuses on dispersing the stagnated live-QI to relieve the stagnation of QI, promoting flow of QI and blood, and analgesic effect is stronger, includes promoting the circulation of QI to relieve pain, promoting blood circulation and stopping pain and stasis-dispelling and pain-killing, menstruction regulating and pain relieving.Modern medicine study thinks that this type of medicine has the effect of regulating body's immunity.
Pure Chinese medicinal preparation of the present invention can be used for the treatment with dysmenorrhea, menoxenia, menstrual period discomfort, sexual anhedonia, pelvic pain, infertile grade is the endometriosis of clinical symptoms.Prove that through animal pharmacology, pharmacodynamics test this Chinese medicine preparation has no side effect, have to make that Ectopic Endometrium atrophy, body of gland dwindle, the effect of tissue necrosis.Through the clinical case test, total effective rate is 92.5%, wherein fully recovers 22.3%, produce effects 35.8%, effective 34.4%.This Chinese medicine preparation can be made into multiple dosage form, as mixture, tablet, extractum, capsule and ball, loose etc., is convenient to take.
Embodiment:
1, get Radix Salviae Miltiorrhizae 15g, Rhizoma Curcumae 8g, Radix Bupleuri 10g, Radix Paeoniae Rubra 10g, Radix Angelicae Sinensis 12g, rhizoma sparganic 8g, Rhizoma Cyperi 8g, Rhizoma Corydalis 6g, Oletum Trogopterori 8g, Radix Achyranthis Bidentatae 10g, Radix Curcumae 10g, Radix Glycyrrhizae 4g, Radix Notoginseng 3g, fragmentation, water decocts, and makes the 250ml mixture.
2, get Radix Salviae Miltiorrhizae 25g, Rhizoma Curcumae 10g, Radix Bupleuri 13g, Radix Paeoniae Rubra 18g, Radix Angelicae Sinensis 30g, rhizoma sparganic 12g, Rhizoma Cyperi 6g, Rhizoma Corydalis 10g, Oletum Trogopterori 14g, Radix Achyranthis Bidentatae 20g, Radix Curcumae 15g, Radix Glycyrrhizae 12g, Radix Notoginseng 5g, the Radix Notoginseng pulverizing is stand-by, Radix Salviae Miltiorrhizae, Rhizoma Curcumae alcohol extraction are stand-by, all the other waters decoct, concentrate, add the Radix Notoginseng, Radix Salviae Miltiorrhizae, the Rhizoma Curcumae that have prepared, obtain extractum.
Claims (1)
1, a kind of gynecopathy Chinese medicine preparation, it is characterized in that described preparation composition is: Radix Salviae Miltiorrhizae 10-45g, Rhizoma Curcumae 8-20g, Radix Bupleuri 10-20g, Radix Paeoniae Rubra 10-20g, Radix Angelicae Sinensis 10-30g, rhizoma sparganic 6-20g, Rhizoma Cyperi 6-15g, Rhizoma Corydalis 6-15g, Oletum Trogopterori 6-20g, Radix Achyranthis Bidentatae 10-30g, Radix Curcumae 10-30g, Radix Glycyrrhizae 4-20 g, Radix Notoginseng 3-30g, described preparation is an oral formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97120991A CN1078078C (en) | 1997-12-05 | 1997-12-05 | Traditional Chinese medicinal preparation for curing gynecopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97120991A CN1078078C (en) | 1997-12-05 | 1997-12-05 | Traditional Chinese medicinal preparation for curing gynecopathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1223119A true CN1223119A (en) | 1999-07-21 |
| CN1078078C CN1078078C (en) | 2002-01-23 |
Family
ID=5176118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97120991A Expired - Lifetime CN1078078C (en) | 1997-12-05 | 1997-12-05 | Traditional Chinese medicinal preparation for curing gynecopathy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1078078C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537095A (en) * | 2009-04-29 | 2009-09-23 | 北京星昊医药股份有限公司 | Traditional Chinese medicine composition used for gynae regulating the menstrual function |
| CN102671108A (en) * | 2011-03-07 | 2012-09-19 | 中国中医科学院广安门医院 | Applications for traditional Chinese medicine pharmaceutical composition |
| CN105056129A (en) * | 2015-08-17 | 2015-11-18 | 青岛云天生物技术有限公司 | Traditional Chinese medicine preparation for treating endometriosis and preparation method thereof |
| CN108272936A (en) * | 2018-01-29 | 2018-07-13 | 王学奎 | A kind of the drug composition and preparation method of palace of the Qing Dynasty blood stasis removing pill |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081107A (en) * | 1992-03-16 | 1994-01-26 | 山东青岛中西医结合医院 | Medicine for endometriosis and manufacturing process thereof |
| CN1048900C (en) * | 1995-06-05 | 2000-02-02 | 中国人民解放军南京军区南京总医院 | Formula of traditional Chinese medicine for curing endometriosis and preparation and preparation technology thereof |
-
1997
- 1997-12-05 CN CN97120991A patent/CN1078078C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537095A (en) * | 2009-04-29 | 2009-09-23 | 北京星昊医药股份有限公司 | Traditional Chinese medicine composition used for gynae regulating the menstrual function |
| CN102671108A (en) * | 2011-03-07 | 2012-09-19 | 中国中医科学院广安门医院 | Applications for traditional Chinese medicine pharmaceutical composition |
| CN102671108B (en) * | 2011-03-07 | 2014-03-19 | 中国中医科学院广安门医院 | Applications for traditional Chinese medicine pharmaceutical composition |
| CN105056129A (en) * | 2015-08-17 | 2015-11-18 | 青岛云天生物技术有限公司 | Traditional Chinese medicine preparation for treating endometriosis and preparation method thereof |
| CN108272936A (en) * | 2018-01-29 | 2018-07-13 | 王学奎 | A kind of the drug composition and preparation method of palace of the Qing Dynasty blood stasis removing pill |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1078078C (en) | 2002-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: CAI LISHAN Free format text: FORMER OWNER: NONE Effective date: 20030919 Owner name: KUMING DIANHONG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CAI LISHAN |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20030919 Address after: 650106 No. 45, medical Road, hi tech Development Zone, Yunnan, Kunming Co-patentee after: Cai Lishan Patentee after: Kuning Dianhong Pharmaceutical Co., Ltd. Address before: 650101 the Second Affiliated Hospital of Kunming Medical University, 1 Ma Yuan Garden, Kunming, Yunnan Patentee before: Cai Lishan |
|
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shanghai Dihon Pharmaceutical Co., Ltd. Assignor: Kuning Dianhong Pharmaceutical Co., Ltd.|Cai Lishan Contract fulfillment period: 2009.10.25 to 2017.12.5 contract change Contract record no.: 2009530000047 Denomination of invention: Traditional Chinese medicinal preparation for curing gynecopathy Granted publication date: 20020123 License type: General permission Record date: 2009.12.2 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: COMMON LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.10.25 TO 2017.12.5; CHANGE OF CONTRACT Name of requester: SHANGHAI DIHON PHARMACEUTICAL CO., LTD. Effective date: 20091202 |
|
| C56 | Change in the name or address of the patentee |
Owner name: DIHON PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: KUNING DIANHONG PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 650106 Kunming science and Technology Development Zone, Yunnan Province Road No. 45 Co-patentee after: Cai Lishan Patentee after: Dihon Pharmaceutical Group Co., Ltd. Address before: 650106 Kunming science and Technology Development Zone, Yunnan Province Road No. 45 Co-patentee before: Cai Lishan Patentee before: Kuning Dianhong Pharmaceutical Co., Ltd. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20020123 |