CN1048900C - Formula of traditional Chinese medicine for curing endometriosis and preparation and preparation technology thereof - Google Patents
Formula of traditional Chinese medicine for curing endometriosis and preparation and preparation technology thereof Download PDFInfo
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- CN1048900C CN1048900C CN95111058A CN95111058A CN1048900C CN 1048900 C CN1048900 C CN 1048900C CN 95111058 A CN95111058 A CN 95111058A CN 95111058 A CN95111058 A CN 95111058A CN 1048900 C CN1048900 C CN 1048900C
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- radix
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- paeoniae alba
- achyranthis bidentatae
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Abstract
The present invention relates to a traditional Chinese medicine formulation for treating endometriosis, which is mainly prepared from hemlock parsley, Chinese angelica, radix paeoniae alba, zedoary, sweet wormwood, astragalus root, herba epimedii and radix achyranthis bidentatae. The traditional Chinese medicine formulation can be prepared into various preparation forms, the total effective rate of the formulation for treating endometriosis is as high as 90%, and dysmenorrhoea symptoms can be obviously relieved. In addition, liver function damage and other toxic and side effects are not found, and the formulation achieves low relapse rate.
Description
The invention belongs to the medical supplies that contain material of vegetable origin.
The method of treatment endometriosis is a lot of both at home and abroad at present, as expectation therapy, pharmacotherapy, operative therapy, medicine and operation composite treatment etc.(Zhu Heling etc., " foreign medical science obstetrics and gynecology fascicle ", 1991 are selected in the treatment of endometriosis; 18 (2): 887).A kind of evaluation of Therapeutic Method generally should be considered following factor: effectiveness, side effect, treatment in the past, relapse rate and expense etc.But though the operative treatment alleviating pain, the relapse rate height.At drug treatment, external danazol (Danazol) pseudo menopause therapies that adopt more, this method is to reduce the activity of focus by medicine, and it is faded away.This method is being improved the state of an illness and is being continued aspect the utilization rate all than pseudo pregnancy therapy strong (Lian Lijuan, the new development " Chinese journal of obstetrics and gynecology " 1989 of endometriosis diagnosis and treatment; 24 (2): 111).Although danazol is to treat medicine (Wu Ming etc., the tamoxifen application in gynecopathy therapeutic, " the Chinese journal of obstetrics and gynecology " 1994 that endometriosis generally uses now; 29 (10): 628), but its shortcoming is to cause the low estrogen environment, thereby causes the Ectopic Endometrium regression, and (Xie Xing etc., tamoxifen is treated revaluing of endometriosis to occur side reactions such as battle array heat, flushing, bone loss thus." foreign medical science obstetrics and gynecology fascicle ", 1994; 21 (2): 9).Also influence the generation of patient's liver function and platelet, hemoglobin simultaneously, often in infringement (Shi Lvqin etc., the individuation of endometriosis Therapeutic Method, " foreign medical science obstetrics and gynecology fascicle ", 1994 that treatment can cause liver function in early days; 21 (2): 99).
Therefore seek the curative effect height in tcm field, side effect is little, and the Drug therapy endometriosis that relapse rate is low becomes the clinical problem of department of obstetrics and gynecology that people pay close attention to.
The special side of Chinese traditional treatment endometriosis is existing: blood circulation promoting and blood stasis dispelling side (rhizoma sparganic, Rhizoma Curcumae, Pollen Tyjphae, king's Oletum Trogopterori, Semen Persicae), the kidney invigorating blood stasis dispelling side (Herba Epimedii, Rhizoma Curculiginis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Caulis Spatholobi, Radix Salviae Miltiorrhizae, Rhizoma Cyperi, rhizoma sparganic, Rhizoma Curcumae), dysmenorrhea diffusing (Radix Angelicae Sinensis, the Radix Paeoniae Alba, Cortex Moutan, Flos Carthami, Rhizoma Cyperi, Radix Curcumae, Fructus Toosendan, Rhizoma Curcumae, the Radix Linderae, Rhizoma Corydalis, Rhizoma Chuanxiong), gossypol (Hong Wenxu, the Chinese traditional treatment overview of endometriosis " the Shaanxi traditional Chinese medical science " 1992; 13 (5): 234) and Tripterygium glycosides (Chen Defu etc. use Tripterygium glycosides treatment endometriosis clinical observation on the therapeutic effect preliminary report " national combination of Chinese and Western medicine endometriosis seminar data " 1992.5), medicine for endometriosis (Radix Salviae Miltiorrhizae, Rhizoma Cyperi etc.) (Jiao Ximei etc., medicine for endometriosis treatment endometriosis 110 routine clinical experimental research " national combination of Chinese and Western medicine endometriosis seminar data " 1992.5) etc.Though its curative effect report reaches 90%, the matched group contrast that the data deficiency that has is scientific and reasonable and unreliable, the shortage animal data that has, the medicine that has is difficult for obtaining, and costs an arm and a leg, and the then side effect that has is obvious.
The Chinese medicine, preparation and the processing technology that the purpose of this invention is to provide a kind of evident in efficacy, side effect is little, relapse rate is low, cheap treatment endometriosis.
Technical solution of the present invention is: treatment endometriosis Chinese medicine mainly is made up of Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Curcumae, the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae, Herba Artemisiae Annuae.Their weight proportion is: 1 part of Rhizoma Chuanxiong, Radix Angelicae Sinensis 0.2-2 part, Radix Paeoniae Alba 0.3-3 part, Rhizoma Curcumae 0.3-2.5 part, 0.55 part of the Radix Astragali, Herba Epimedii 0.4-4 part, Radix Achyranthis Bidentatae 0.2-2 part, Herba Artemisiae Annuae 0.5-5 part.This Chinese prescription can be made granule, tablet, capsule, pill and oral liquid.
The processing technology of granule is: after getting Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, Herba Artemisiae Annuae and extracting volatile oil routinely, merge with the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae and to decoct with water.Decoction liquor is filtered, and concentrates, and is dry then, beats powder.The volatile oil of said extracted is sprayed in the powder granulate, packing.
The processing technology of tablet is: preceding road technology such as granule technology, and decoction liquor is filtered, and filtrate concentrates, and is dry, beat powder, adds an amount of ethanol, and the drying of granulating sprays into volatile oil, and granulate dries, and adds an amount of magnesium stearate, tabletting, wraps film-coat.
Capsular processing technology is: preceding road technology such as granule technology, and decoction liquor is filtered, and filtrate concentrates, and drying is beaten powder, sprays into the volatile oil of extraction, dries, and is encapsulated.
The processing technology of pill is: get the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae and decoct with water, decoction liquor is filtered, is concentrated.Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, Herba Artemisiae Annuae are ground into powder, sieve, mixing is with above-mentioned concentrated solution and water pill, drying, packing.
The processing technology of oral liquid is: preceding road technology such as granule technology, decoction liquor adds the volatile oil of sweeting agent and extraction after filtering, stirs evenly bottling.
Reach 90% with treatment by Chinese herbs endometriosis total effective rate of the present invention, with danazol matched group contrast no significant difference (p＞0.05), can obviously improve the dysmenorrhea symptom, contrast also no significant difference (p＞0.05) with the danazol matched group, none example has liver function injury, and danazol matched group 40% finds to have liver function injury (10/25), and treatment by Chinese herbs group of the present invention finds no other any toxicities, relapse rate is 10% (5/50) after drug withdrawal half a year, is lower than danazol matched group 40% (10/25) (p＜0.01).From aspects overall merits such as effectiveness, side effect, relapse rate, expenses, treatment by Chinese herbs endometriosis of the present invention is better than danazol.Set up house by film grafting in utero and exempt from model of endometriosis research, the result shows that Chinese medicine of the present invention truly has the in utero effect of film growth of dystopy that suppresses, and in utero the effect of film is more obvious than the effect that suppresses the growth of normal uterus inner membrance to suppress dystopy, illustrates that its effect that suppresses the growth of dystopy endometrium has certain specific aim.
The processing technology of embodiment 1. granules:
Get Rhizoma Chuanxiong 125g, Radix Angelicae Sinensis 125g, Radix Paeoniae Alba 125g, Rhizoma Curcumae 125g, Herba Artemisiae Annuae 125g, behind multipotency formula Chinese medicine extraction jar extraction volatile oil, decoct with water 3 times with Radix Astragali 125g, Herba Epimedii 125g, Radix Achyranthis Bidentatae 125g merging, each 2 hours, merge decoction liquor, filter, concentrate, spray drying, the volatile oil of said extracted is sprayed in the powder, granulate is sub-packed in plastic bag.
The processing technology of embodiment 2. tablets:
Get Rhizoma Chuanxiong 125g, Radix Angelicae Sinensis 50g, Radix Paeoniae Alba 75g, Rhizoma Curcumae 250g, Herba Artemisiae Annuae 200g, behind multipotency formula Chinese medicine extraction jar extraction volatile oil, decoct with water 3 times with Radix Astragali 200g, Herba Epimedii 50g, Radix Achyranthis Bidentatae 50g merging, each 2 hours, merge decoction liquor, filter, filtrate is concentrated into paste, and vacuum drying is beaten powder, add ethanol, granulate drying, spray into the volatile oil of extraction, granulate dries, add an amount of magnesium stearate, tabletting is wrapped film-coat.
Embodiment 3. capsular processing technology:
Get Rhizoma Chuanxiong 100g, Radix Angelicae Sinensis 175g, Radix Paeoniae Alba 200g, Rhizoma Curcumae 50g, Herba Artemisiae Annuae 150g, behind multipotency formula Chinese medicine extraction jar extraction volatile oil, decoct with water each 2 hours 3 times with Radix Astragali 50g, Herba Epimedii 250g, Radix Achyranthis Bidentatae 25g merging, merge decoction liquor, filter, filtrate is concentrated into paste, vacuum drying, beat powder, spray into volatile oil, dry, encapsulated.
The processing technology of embodiment 4. pills:
Get Radix Astragali 75g, Herba Epimedii 500g, Radix Achyranthis Bidentatae 75g, decoct with water 3 times, each 2 hours, merge decoction liquor, filter, filtrate suitably concentrates, and Rhizoma Chuanxiong 125g, Radix Angelicae Sinensis 250g, Radix Paeoniae Alba 50g, Rhizoma Curcumae 300g, Herba Artemisiae Annuae 75g are ground into fine powder, crosses 120 mesh sieves, mixing, with above-mentioned concentrated solution and water pill, drying, packing.
Embodiment 5. oral liquid processing technology:
Get Rhizoma Chuanxiong 125g, Radix Angelicae Sinensis 125g, Radix Paeoniae Alba 125g, Rhizoma Curcumae 125g, Herba Artemisiae Annuae 125g, behind multipotency formula Chinese medicine extraction jar extraction volatile oil, decoct with water 3 times with Radix Astragali 125g, Herba Epimedii 125g, Radix Achyranthis Bidentatae 125g merging, each 2 hours, merge decoction liquor, filter, concentrate, behind the volatile oil of adding sweeting agent and extraction, stir evenly, bottle.
Claims (7)
1. treat endometriosis Chinese medicine for one kind, it is characterized in that by raw material Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae, Herba Artemisiae Annuae are made, and the weight ratio of its material component is: 1 part of Rhizoma Chuanxiong, Radix Angelicae Sinensis 0.2-2 part, Radix Paeoniae Alba 0.3-3 part, Rhizoma Curcumae 0.3-2.5 part, Radix Astragali 0.5-5 part, Herba Epimedii 0.4-4 part, Radix Achyranthis Bidentatae 0.2-2 part, Herba Artemisiae Annuae 0.5-5 part.
2. Chinese medicine according to claim 1 is characterized in that making granule, tablet, capsule, oral liquid or pill.
3. processing technology for preparing the granule of Chinese medicine as claimed in claim 1, it is characterized in that: after getting Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, Herba Artemisiae Annuae and extracting volatile oil routinely, decoct with water with the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae merging, the decoction liquor filtering and concentrating, dry, the volatile oil of said extracted is sprayed in the powder granulate, packing.
4. processing technology for preparing the tablet of Chinese medicine as claimed in claim 1 is characterized in that: after getting Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, Herba Artemisiae Annuae and extracting volatile oil according to a conventional method, merge with the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae and to decoct with water, the decoction liquor filtering and concentrating, drying is beaten powder, add an amount of alcohol granulation, drying sprays into volatile oil, granulate, dry, add an amount of magnesium stearate, tabletting is wrapped film-coat.
5. capsular processing technology for preparing Chinese medicine as claimed in claim 1, it is characterized in that: after getting Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, Herba Artemisiae Annuae and extracting volatile oil according to a conventional method, decoct with water with the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae merging, filter decoction liquor, filtrate concentrates, drying, beat powder, spray into the volatile oil of extraction, dry, encapsulated.
6. processing technology for preparing the pill of Chinese medicine as claimed in claim 1 is characterized in that: get the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae and decoct with water filtering and concentrating, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, Herba Artemisiae Annuae are ground into powder, sieve, mixing, with above-mentioned concentrated solution and water pill, drying, packing.
7. processing technology for preparing the oral liquid of Chinese medicine as claimed in claim 1, it is characterized in that: after getting Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Curcumae, Herba Artemisiae Annuae and extracting volatile oil routinely, decoct with water with the Radix Astragali, Herba Epimedii, Radix Achyranthis Bidentatae merging, filter, after adding the volatile oil of sweeting agent and said extracted in the filtrate, stir evenly bottling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95111058A CN1048900C (en) | 1995-06-05 | 1995-06-05 | Formula of traditional Chinese medicine for curing endometriosis and preparation and preparation technology thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95111058A CN1048900C (en) | 1995-06-05 | 1995-06-05 | Formula of traditional Chinese medicine for curing endometriosis and preparation and preparation technology thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1123178A CN1123178A (en) | 1996-05-29 |
| CN1048900C true CN1048900C (en) | 2000-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95111058A Expired - Fee Related CN1048900C (en) | 1995-06-05 | 1995-06-05 | Formula of traditional Chinese medicine for curing endometriosis and preparation and preparation technology thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078078C (en) * | 1997-12-05 | 2002-01-23 | 蔡利珊 | Traditional Chinese medicinal preparation for curing gynecopathy |
| CN1091607C (en) * | 1998-03-05 | 2002-10-02 | 陈寿熙 | Jingshutong soluble granules |
| CN100418549C (en) * | 2003-10-30 | 2008-09-17 | 山西亚宝药业集团股份有限公司 | Chinese medicinal composition for treating endometriosis menstrual ab dominal pain and its preparing method |
| CN1318066C (en) * | 2005-01-26 | 2007-05-30 | 河北省医学科学院 | Medicine for treating dysmenorrhes and preparation thereof |
-
1995
- 1995-06-05 CN CN95111058A patent/CN1048900C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《上海中医药杂志》1993,(2) 1993.2.28 马敏珠，血府逐瘀治疗子宫内膜异位症83例 * |
| 《江苏中医杂志》1987,8(1) 1987.1.30 孙锡元，子宫内膜支气管异位症 * |
| 《江苏中医杂志》1987,8(1) 1987.1.30 孙锡元，子宫内膜支气管异位症;《上海中医药杂志》1993,(2) 1993.2.28 马敏珠，血府逐瘀治疗子宫内膜异位症83例 * |
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| Publication number | Publication date |
|---|---|
| CN1123178A (en) | 1996-05-29 |
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