CN1215059A - Extration of steroid compound from rubber seeds - Google Patents
Extration of steroid compound from rubber seeds Download PDFInfo
- Publication number
- CN1215059A CN1215059A CN 97119744 CN97119744A CN1215059A CN 1215059 A CN1215059 A CN 1215059A CN 97119744 CN97119744 CN 97119744 CN 97119744 A CN97119744 A CN 97119744A CN 1215059 A CN1215059 A CN 1215059A
- Authority
- CN
- China
- Prior art keywords
- residue
- hevea seed
- extract
- sterol
- seed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
The present invention relates to a method for extracting sterol compound by using rubber seed, and is characterized by that said method includes the following steps: shelling; fleshing; after hydrolyzing, separating out fatty acid, waxy material and residue; using organic solvent to extract waxy material and residue together to obtain the liquid extract containing sterol compound; concentrating the liquid extract and recovering the organic solvent, cooling, centrifugal separating out deposit matter, and recrystallization so as to obtain sterol.
Description
The present invention belongs to the method for extracting pharmaceutical industries raw material and medicine.
The raw material of existing synthesizing steroid hormone drug is mainly derived from dioscin in early days, afterwards because the more living phase of medicine source plant resource was long, and demand is big, adds that blindness excavates and resource is petered out.If the artificial culture ripening stage is long, content is very low, the cost height.Some countries are devoted to use instead other animal and plant resources and extract bulk drug and be used for the synthesizing steroid medicine for this reason.Utilize phytosterin compound to make raw material, only account for 6% of total amount, accounted for 70%, from soybean, extract Sitosterol as U.S. Sai Er pharmaceutical factory and entered suitability for industrialized production as the steroid drugs raw material to 1991 in nineteen sixty-eight.Mitsubishi chemical industrial company adopts and extract cholesterol system steroid drugs from lanolin.West Germany extracts Sitosterol from soybean, the general strong company of the U.S. with the method for transforming the steroidal structure sterol as the raw material production steroid drugs.Sterol suitability for industrialized production AD and ADD (androstane-4-alkene-3 .17 diketone and androstane-1.4-diene-3.17 diketone) have been utilized abroad.Under day Benson nearly 30 tame pharmaceutical factories such as Pharmaceutical Co., Ltd directly Stigmasterol as medicinal, the absorption that suppresses cholesterol improves cardiovascular and cerebrovascular disease.
The purpose of this invention is to provide a kind of method of extracting phytosterin compound with hevea seed.
The present invention shells hevea seed, gets meat, after hydrolysis, isolates lipid acid, wax and residue; Wax and residue one are reinstated extraction phytosterin compounds such as organic solvent toluene, sherwood oil.Extracting solution concentrate to reclaim organic solvent, cooling, and the centrifugal throw out of telling is at sherwood oil: butanone: under the condition of ethanol=3: 1: 2, obtain sterol through recrystallization.
Hevea seed of the present invention extracts sterol, and to have a cost low, and raw material sources are wide, can turn waste into wealth, and technology is simple.
Embodiment:
1, hevea seed shells 100 kilograms, and passing through extracts oil obtains oil and oil cake, oil adds sodium hydroxide and carries out saponification, and saponified adding hydrochloric acid obtains lipid acid, and unsaponifiables is dried after adding calcium hydroxide, oil cake adds 4% hydrochloric acid and is hydrolyzed, oven dry is again extracted last two kinds of oven dry things with organism such as sherwood oil or chloroforms, obtain extracting solution, reclaim solvent, obtain throw out through centrifugation,, obtain 1.8 kilograms sterol throw out recrystallization, drying.
2, hevea seed adds 4% hydrochloric acid post-heating for 100 kilograms, obtain jelly, oily matter and residue, oily matter obtains lipid acid through dehydration, the jelly oven dry, and residue adds calcium hydroxide through separating oven dry, oven dry thing organic solvent extraction, obtain extracting solution, reclaim organic solvent, separate obtaining throw out, with throw out recrystallization and drying, obtain 2.0 kilograms sterol.
3,100 kilograms of hevea seed chloroform refluxing extraction obtain extracting solution, reclaim chloroform, add sodium hydroxide and carry out saponification in fluid, saponification liquor adds sherwood oil and obtains extracting solution, reclaims sherwood oil, precipitation separation with throw out recrystallization and drying, obtains 1.8 kilograms sterol.
Claims (4)
1, extracts phytosterin compound with hevea seed, it is characterized in that: be that raw material extracts sterol with the hevea seed.
2, according to claim 1ly extract phytosterin compound with hevea seed, it is characterized in that: extracting phytosterin compound with hevea seed is that hevea seed is shelled, and gets meat, after hydrolysis, isolates lipid acid and wax, residue; Wax and residue one are reinstated the organic solvent refluxing extraction, and extracting solution concentrates and reclaims organic solvent, cooling, and the centrifugal throw out of telling obtains sterol through recrystallization.
3, according to claim 1ly extract phytosterin compound, it is characterized in that: with wax with residue one reinstates sherwood oil or toluene is made solvent with hevea seed.
4, according to claim 1ly extract phytosterin compound, it is characterized in that: sherwood oil: butanone: under the condition of ethanol=3: 1: 2, carry out recrystallization with hevea seed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97119744 CN1107074C (en) | 1997-10-18 | 1997-10-18 | Extration of steroid compound from rubber seeds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97119744 CN1107074C (en) | 1997-10-18 | 1997-10-18 | Extration of steroid compound from rubber seeds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1215059A true CN1215059A (en) | 1999-04-28 |
| CN1107074C CN1107074C (en) | 2003-04-30 |
Family
ID=5175541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97119744 Expired - Fee Related CN1107074C (en) | 1997-10-18 | 1997-10-18 | Extration of steroid compound from rubber seeds |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1107074C (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106092818A (en) * | 2016-08-25 | 2016-11-09 | 西双版纳华坤生物科技有限责任公司 | The assay method of natural rubber content in a kind of seeds of rubber tree oil |
| CN109793793A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of hypoglycemic substance for Gestational hyperglycemia, using and preparation method thereof |
| CN109793808A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | It is a kind of for preventing and treating the substance and purposes of parkinsonism |
| CN109793809A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of substance and preparation method and purposes for preventing and treating hyperlipemia |
| CN109793803A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method of the substance preventing and treating atherosclerosis |
| CN109793783A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method for alzheimer's disease prevention and treatment substance |
| CN109793230A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method of the substance improving intelligence |
| CN109793776A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method for anticoagulant substance |
| CN109793792A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of material for lowering blood pressure for gestation hypertension, using and preparation method thereof |
| CN109793788A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of substance of reducing blood lipid, using and preparation method thereof |
| CN109793805A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | It is a kind of improve immunity substance and its application |
| CN109793785A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of hypoglycemic substance for type II diabetes, using and preparation method thereof |
| CN109793224A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | It is a kind of for improving the preparation and its application of the substance of skin skin quality |
| CN109793790A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of substance of blood pressure lowering, using and preparation method thereof |
| CN109793794A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of substance, the preparation method and applications of alleviation and treatment gout |
| CN109793228A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method thereof for improving the substance of memory |
| CN114921283A (en) * | 2015-09-30 | 2022-08-19 | 公立大学法人大阪 | Method and apparatus for producing vegetable oil |
-
1997
- 1997-10-18 CN CN 97119744 patent/CN1107074C/en not_active Expired - Fee Related
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114921283A (en) * | 2015-09-30 | 2022-08-19 | 公立大学法人大阪 | Method and apparatus for producing vegetable oil |
| CN106092818A (en) * | 2016-08-25 | 2016-11-09 | 西双版纳华坤生物科技有限责任公司 | The assay method of natural rubber content in a kind of seeds of rubber tree oil |
| CN109793792A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of material for lowering blood pressure for gestation hypertension, using and preparation method thereof |
| CN109793788A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of substance of reducing blood lipid, using and preparation method thereof |
| CN109793803A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method of the substance preventing and treating atherosclerosis |
| CN109793783A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method for alzheimer's disease prevention and treatment substance |
| CN109793230A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method of the substance improving intelligence |
| CN109793776A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method for anticoagulant substance |
| CN109793808A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | It is a kind of for preventing and treating the substance and purposes of parkinsonism |
| CN109793809A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of substance and preparation method and purposes for preventing and treating hyperlipemia |
| CN109793805A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | It is a kind of improve immunity substance and its application |
| CN109793785A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of hypoglycemic substance for type II diabetes, using and preparation method thereof |
| CN109793224A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | It is a kind of for improving the preparation and its application of the substance of skin skin quality |
| CN109793790A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of substance of blood pressure lowering, using and preparation method thereof |
| CN109793794A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of substance, the preparation method and applications of alleviation and treatment gout |
| CN109793228A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method thereof for improving the substance of memory |
| CN109793793A (en) * | 2017-11-16 | 2019-05-24 | 徐爽 | A kind of hypoglycemic substance for Gestational hyperglycemia, using and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1107074C (en) | 2003-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1107074C (en) | Extration of steroid compound from rubber seeds | |
| CN103951722A (en) | Method for jointly extracting hesperidin and pectin from citrus peels | |
| CN109646992A (en) | The method of cannabidiol enriched substance is extracted from industrial hemp | |
| CN1053892C (en) | Preparation method of diversine | |
| CN107312054A (en) | A kind of method that urso and Tauro ursodesoxy cholic acid are synthesized from pig's bile | |
| CN101014348B (en) | Ethanol extraction of phytosterols from corn fiber | |
| CN1283654C (en) | Method for preparing cheodexycholic acid | |
| CN101775048A (en) | Method for preparing salidroside from rhodiola rosea | |
| CN106831806B (en) | A kind of preparation method of water solubility sesamin | |
| CN108774281B (en) | Method for extracting phytosterol from cottonseed acidified oil | |
| AU2018307222B2 (en) | Spent turmeric - methods and compositions thereof | |
| CN113588485B (en) | Method for extracting total unsaponifiable matter from vegetable oil | |
| CN1234723C (en) | Method for extracting fucosterol from alga | |
| CN101591231B (en) | Extraction technology for ammonium oxalate of bombyx batryticatus | |
| CN110724085B (en) | Co-production method for extracting bilirubin, hyodeoxycholic acid and chenodeoxycholic acid from pig bile | |
| CN105037313B (en) | A kind of method of myricetrin and catechin compounds in separation Chinese waxmyrtle bark | |
| CN1054788A (en) | Process for extracting grease and tea saponin by one-step leaching of cake dregs | |
| Kind et al. | Steroids of the Virginia snakeroot, Aristolochia serpentaria | |
| DK169075B1 (en) | Method for extracting laxative compounds from mustard drugs | |
| CN104705662A (en) | Method for extracting composite flax dietary fiber | |
| CN1589835A (en) | Mulberry leaf extract and its use | |
| CN103202862B (en) | Capsule shell containing dregs, preparation device of capsule shell, and using method of device | |
| CN1033456C (en) | Separation-extraction technology of cyclovirobuxine and its pills | |
| US3772361A (en) | Processes for preparing 25-hydroxycholecalciferol | |
| CN105418715B (en) | The method that carbon dioxide supercritical extraction method extracts chenodeoxycholic acid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1053657 Country of ref document: HK |