CN1589835A - Mulberry leaf extract and its use - Google Patents
Mulberry leaf extract and its use Download PDFInfo
- Publication number
- CN1589835A CN1589835A CN 03139028 CN03139028A CN1589835A CN 1589835 A CN1589835 A CN 1589835A CN 03139028 CN03139028 CN 03139028 CN 03139028 A CN03139028 A CN 03139028A CN 1589835 A CN1589835 A CN 1589835A
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- CN
- China
- Prior art keywords
- folium mori
- extract
- mulberry
- mulberry leaf
- leaf extract
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A mulberry leaf extract contains mulberroflavone, mulberropolyphenol, mulberropolyose, DNJ, GABA, etc and can be used to prevent and cure cardiovascular and cerebrovascular diseases, hyperlipemia, diabetes and obesity and delaying senility. It is prepared from mulberry leaves through drying in air, pulverizing, extracting and spray drying.
Description
Invention field:
The invention belongs to Chinese medicine extract, is a kind of Folium Mori extract with medical care effect.
Background of invention:
What contain flavones in mulberry leaves, polyphenol, polysaccharides of Folium Mori, DNJ, plant sterol, GABA, multivitamin, mineral, aminoacid and other the unknowns in the Folium Mori has the active substance of medical care effect to human body, different physiological roles such as have blood sugar lowering, blood fat reducing, vessel softening, heart tonifying, removing free radical, defying age, fat-reducing, antiinflammatory, antiallergic, antitumor, AIDS resisting, diuresis, spasmolytic, antitussive, relieving asthma is remarkable with control cardiovascular and cerebrovascular disease, hyperlipemia, diabetes, obesity and anti-aging effects especially.Utilize these biological active substances exploitation health foods and medicine to have bright development prospect.The present invention finds, by three kinds of solvent lixiviates, the major physiological active substance in the Folium Mori can be extracted.
Goal of the invention:
Purpose of the present invention is intended to effectively to obtain the main health care active substance in the Folium Mori, is used to develop health food and medicine.
Summary of the invention:
The present invention finds:
One, the content of the health care active component in the Folium Mori is the highest with content in the 1st～3 young leaves on the mulberry branch before the silkworm in spring later stage or the Frost's Descent.
Two, the health care extraction method of active ingredients in the Folium Mori is to use the n-butyl alcohol lixiviate earlier, and flooding is used in reuse 90% ethanol lixiviate then, at last three kinds of extracts is merged, and after the spray drying, makes powder.
Three, the extract that obtains according to the method described above, contain several physiological active substances such as flavones in mulberry leaves, mulberry leaf polyphenol, polysaccharides of Folium Mori, DNJ, GABA, be used to produce health food or medicine, control cardiovascular and cerebrovascular disease, hyperlipemia, diabetes, obesity and defying age are had remarkable result.
The invention advantage:
One, correlational study and invention all are directly to produce after-product with Folium Mori or extract wherein a kind of effective ingredient from Folium Mori, and value is lower.The present invention is by three kinds of solvent lixiviates, contains most of biological active substances in extract obtained, both can be directly used in and produce health food and medicine, also can be used as medical primary raw materials, and further the single active component of planting of separation and purification has more wide purposes.
Two, related invention is not determined the relation of Folium Mori type and active component content, the determined Folium Mori of the present invention, and active constituent content is the highest.
Technological process:
Preparation technology's flow process of Folium Mori extract is as " Figure of description ".
Description of drawings:
Fig. 1; Folium Mori extract preparation technology flow chart
1 is to pluck 1-3 position Folium Mori on the mulberry branch among Fig. 1; The 2nd, dry in the shade; The 3rd, be crushed to the 50-100 order; The 4th, quantitatively; The 5th, the n-butyl alcohol lixiviate; The 6th, filter; The 7th, filtrate; The 8th, concentrating under reduced pressure; The 9th, extract I; The 10th, residue; 11 is 90% ethanol lixiviates; The 12nd, filter; The 13rd, filtrate; 14 concentrating under reduced pressure; The 15th, extract II; The 16th, residue; The 17th, flooding; The 18th, filter; The 19th, filtrate; The 20th, extract II I; The 21st, extract I, extract II, extract II I are merged; The 22nd, spray drying; The 23rd, low temperature seal is stored.
Most preferred embodiment of the present invention:
The raw material that the present invention relates to is the 1-3 position young leaves on the mulberry branch before the silkworm in spring later stage or the Frost's Descent in late fall, plucks this kind Folium Mori, dries in the shade fast, is crushed to the 50-100 order with pulverizer, stores standby.
Below all multiples all refer to weight ratio.
Step 1:
Get 1 part of powder of Folium Mori, add 4 times n-butyl alcohol, 60 ℃ of stirring and leaching 3 hours are filtered, filtrate, filtrate decompression is concentrated, extract I.
Step 2:
Residue obtained with filtering in the step 1, add 90% ethanol of 6 times of former powder of Folium Mori amounts, 60 ℃ of stirring and leaching 3 hours are filtered, filtrate decompression is concentrated, extract II.
Step 3:
Residue obtained with filtering in the step 2, add the distilled water of 40 times of former powder of Folium Mori amounts, 60 ℃ of stirring and leaching 3 hours are filtered, filtrate, filtrate decompression is concentrated, extract II I.
Step 4:
Said extracted thing I, extract II, extract II I are merged, and spray drying is processed into capsule or other dosage forms.
The Folium Mori extract capsule of being processed into according to above-mentioned example, the using method that is used to prevent or treat cardiovascular and cerebrovascular disease, hyperlipemia, diabetes, defying age and fat-reducing is: the adult takes 900～1200 milligrams every day, divide and take for three times, when having a dinner oral 300～400 milligrams at every turn, after taking for 4～6 weeks continuously, the blood fat of hyperlipidemia patient, diabetics and blood glucose can be controlled in the normal level, and obesity patient's body weight obviously alleviates, and take for a long time even can return to one's perfect health.For prevention cardiovascular and cerebrovascular disease, hyperlipidemia, hypertension and defying age, can take for a long time, effect is remarkable, has no side effect.
Claims (2)
1, a kind of Folium Mori extract with medical care effect, it is characterized in that containing several physiological active substances such as flavones in mulberry leaves, mulberry leaf polyphenol, polysaccharides of Folium Mori, DNJ, GABA, be used to prevent and treat cardiovascular and cerebrovascular disease, hyperlipemia, diabetes, obesity and defying age.
2, above extract with the silkworm in spring later stage or the Frost's Descent before the powder of Folium Mori of the 1st～3 young leaves processing on the mulberry branch be raw material, respectively with the lixiviate of heating of n-butyl alcohol, 90% second alcohol and water, and spray drying and getting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03139028 CN1589835A (en) | 2003-09-01 | 2003-09-01 | Mulberry leaf extract and its use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03139028 CN1589835A (en) | 2003-09-01 | 2003-09-01 | Mulberry leaf extract and its use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1589835A true CN1589835A (en) | 2005-03-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03139028 Pending CN1589835A (en) | 2003-09-01 | 2003-09-01 | Mulberry leaf extract and its use |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1589835A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009152665A1 (en) * | 2008-06-20 | 2009-12-23 | 湖南希尔天然药业有限公司 | A pharmaceutical composition for treating diabetes |
| WO2011032502A1 (en) | 2009-09-16 | 2011-03-24 | Botanic Century (Beijing) Co. Ltd. | Plant extract, compositons containing same, method of extraction and uses thereof |
| CN101450178B (en) * | 2007-12-07 | 2011-06-01 | 于国录 | Medicine for treating diabetes |
| CN102406174A (en) * | 2011-12-02 | 2012-04-11 | 安徽燕之坊食品有限公司 | Functional food composite and application |
| CN106038704A (en) * | 2016-05-25 | 2016-10-26 | 吴敏浩 | Composition for inhibiting food digestion and absorption as well as preparation method and application of composition |
| CN108432919A (en) * | 2018-03-05 | 2018-08-24 | 苏州先蚕丝绸有限公司 | A kind of preparation method of mulberry leaf powder |
-
2003
- 2003-09-01 CN CN 03139028 patent/CN1589835A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450178B (en) * | 2007-12-07 | 2011-06-01 | 于国录 | Medicine for treating diabetes |
| WO2009152665A1 (en) * | 2008-06-20 | 2009-12-23 | 湖南希尔天然药业有限公司 | A pharmaceutical composition for treating diabetes |
| WO2011032502A1 (en) | 2009-09-16 | 2011-03-24 | Botanic Century (Beijing) Co. Ltd. | Plant extract, compositons containing same, method of extraction and uses thereof |
| CN102406174A (en) * | 2011-12-02 | 2012-04-11 | 安徽燕之坊食品有限公司 | Functional food composite and application |
| CN106038704A (en) * | 2016-05-25 | 2016-10-26 | 吴敏浩 | Composition for inhibiting food digestion and absorption as well as preparation method and application of composition |
| CN108432919A (en) * | 2018-03-05 | 2018-08-24 | 苏州先蚕丝绸有限公司 | A kind of preparation method of mulberry leaf powder |
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