CN109793790A - A kind of substance of blood pressure lowering, using and preparation method thereof - Google Patents
A kind of substance of blood pressure lowering, using and preparation method thereof Download PDFInfo
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- CN109793790A CN109793790A CN201711139122.9A CN201711139122A CN109793790A CN 109793790 A CN109793790 A CN 109793790A CN 201711139122 A CN201711139122 A CN 201711139122A CN 109793790 A CN109793790 A CN 109793790A
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- seed
- hevea brasiliensis
- unsaponifiable matter
- substance
- liposoluble substance
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Abstract
The present invention disclose a kind of blood pressure lowering substance, using and preparation method thereof.The substance is plantHevea brasiliensisThe unsaponifiable matter of the liposoluble substance of the seed of (para ruber), to extract fromHevea brasiliensisThe liposoluble substance of (para ruber) seed is raw material, carries out saponification to it, then isolates and purifies out the substance for being not involved in saponification.The substance can be applied to drug, health food, in food, for reducing the blood pressure of hypertensive patient, and it is without side-effects.
Description
Technical field
The present invention disclose a kind of blood pressure lowering substance, using and preparation method thereof, belong to medicine and field of food.
Background technique
China's hypertension hypertension personage's number has broken through 3.3 hundred million, has 1 people to suffer from hypertension in every 3 adults.China at present
Do not know oneself, with hypertension, even in the hypertension personage for receiving treatment, there is height there are about 1.3 hundred million hypertension personages yet
Up to 75% people do not control it is up to standard.It is announced in the recent period as the result is shown at sick prevention and control center slowly according to Chinese Disease Control and Prevention Center: the high blood in China
Pressure illness is just being presented rejuvenation trend, and in 25 years old to 34 years old young men, Prevalence of Hypertension is up to 20.4%.
Hypertension seriously endangers health.According to medical research, 62% stroke event is directly resulted in by hypertension, 49%
Myocardial infarction caused by hypertension.Target control treatment is the key that reduce cardiocerebrovasculaevents events.SBP(systolic pressure) decline 2mmHg,
The ischemic heart disease death rate 7% is then reduced, the stroke death rate 10% is reduced.
Current antihypertensive drugs has different degrees of side effect.Such as the antihypertensive drugs of AT receptor blocker class, it can lead
Cause the adverse reactions such as liver damage, cutaneous lesions, dry cough；The antihypertensive drugs of beta-blocker class, which has, wheezes, peripheral vascular disease
Exacerbation, abnormal carbohydrate metabolism, Anomalous lipid metablism, the side effects such as heart failure；The antihypertensive drugs of 1 receptor blocker class of α has and leads to position
The risk of property low blood pressure and fluid retention.Angiotensin converting enzyme inhibitor (ACEI) hypotensor object has raising blood potassium
Side effect；Thiazide antihypertensive drugs has the side effect of row's potassium；Spirolactone hypotensor object has the side effect for protecting potassium.Antihypertensive drugs
It is generally necessary to be used in combination, to enhance antihypertensive effect, but being used for a long time still has various side effects.
Summary of the invention
Some is not directed to the substance of hypertensive patient's blood pressure lowering the purpose of the present invention is to provide a kind of in the prior art
(Hevea brasiliensisThe unsaponifiable matter of seed liposoluble substance) and its in pharmacy and the application in food.The substance isHevea brasiliensisSeed liposoluble substance unsaponifiable matter, can be applied to drug, health food, food
In, it is used for hypertensive patient's blood pressure lowering.Hypertensive patient passes through daily takes or eats the drug, the health care that are added to the substance
Food, food can be obtained good therapeutic effect.
Hevea brasiliensisIt is general latin name of the plant para ruber at home with the world, in order to accurate
For the sake of, the plant is called with its latin name herein.
In order to realize above-mentioned purpose of the invention, the present invention provides the following technical solutions.
Hevea brasiliensisThe unsaponifiable matter of seed liposoluble substance, the substance are prepared by the following method and obtain.
With freshHevea brasiliensisSeed is raw material, after drying shelling, prepares kernel, kernel passes through machinery
One or more of extrusion, extraction method, supercritical extraction are madeHevea brasiliensisThe liposoluble of seed
Object, then withHevea brasiliensisThe lipoclastic of seed is raw material, and excessive potassium hydroxide-ethanol solution is added and carries out
Saponification, after saponification terminates, under vacuum conditions, heating recovery ethyl alcohol, later be added unsaponifiable matter extractant into
Row extraction, selected extractant are one of ether, ethyl acetate, n-hexane, No. 6 solvents, upper layer of extraction liquid are isolated, true
Reheating under empty condition, recycles extractant, and remaining liquid isHevea brasiliensisThe fat-soluble portion of seed
The unsaponifiable matter divided.
Invention also provides contain the described of therapeutically effective amountHevea brasiliensisThe fat-soluble object of seed
The unsaponifiable matter of matter and the pharmaceutical composition of pharmaceutically acceptable carrier.
And health food, by describedHevea brasiliensisThe unsaponifiable matter of seed liposoluble substance and guarantor
Health food common carrier is formed.
With food, by describedHevea brasiliensisThe unsaponifiable matter and food of seed liposoluble substance are common
Carrier is formed.
The present invention also provides describedHevea brasiliensisThe unsaponifiable matter of seed liposoluble substance is controlled in preparation
Treat the application in the drug of hypertension.
Application as mentioned, wherein describedHevea brasiliensisThe unsaponifiable matter conduct of seed liposoluble substance
Sole active agent.
Present invention further provides describedHevea brasiliensisThe unsaponifiable matter of seed liposoluble substance exists
Application in the health food of preparation treatment hypertension.
And it is describedHevea brasiliensisThe unsaponifiable matter of seed liposoluble substance is in preparation hypertensive patient
Food in application.
Application as mentioned, wherein describedHevea brasiliensisThe unsaponifiable matter conduct of seed liposoluble substance
Sole active agent.
According to experimental data, with it is existing for the drug of hypertensive patient's blood pressure lowering compared with, the present invention has following excellent
Point.
1, the present invention provides a kind of completely new, the substance of hypertension is treated.
2, safety is good, without side-effects, can be used for a long time.
Specific embodiment
Below by the embodiment of the present invention, property content is described further for the essence of the present invention, but is not limited with this
The fixed present invention.
Embodiment 1
It is fresh with 100kgHevea brasiliensisSeed is raw material, after drying shelling, prepares kernel 40kg.Kernel object
Material arrives 80-100 DEG C in heat, and then by static extruding, pressure 50MPa obtains 12kgHevea brasiliensisKind
The liposoluble substance of son.
With 10kgHevea brasiliensisThe lipoclastic of seed is raw material, and 10kg potassium hydroxide-ethanol solution is added
Saponification is carried out, the mass percent concentration of potassium hydroxide in ethanol is 22%.After saponification terminates, 0.01atm is true
Under empty condition, it is heated to 120 DEG C of recycling ethyl alcohol；5kg ether is added later to extract as unsaponifiable matter extractant, isolates upper layer
Extract liquor is heated to 85 DEG C of recycling extractants, obtains 400g liquid under 0.01atm vacuum condition, as of the inventionHevea brasiliensisThe unsaponifiable matter of the fatty contents of seed.
As control, the liposoluble substance for being derived from linseed using 10 kilograms is raw material, under identical condition, prepares flax
The unsaponifiable matter of the liposoluble substance of seed.
40 hypertensive patients are recruited, are randomly divided into two groups, every group of 20 people.First group (experimental group) takes orally substance of the present invention
Manufactured drug, dose are 0.5g/ days (with the meter of substance of the present invention in drug)；Second group (control group) oral linseed
Liposoluble substance unsaponifiable matter, oral dose be 0.5 gram/day.It is detected after 30 days oral.
Testing index is the systolic pressure of patient.Experimental group systolic pressure is from 160 ± 20mmHg before experiment, after being reduced to experiment
133 ± 10mmHg, difference are extremely significant (P < 0.01)；167 ± 21mmHg of systolic pressure before control group is tested, 162 after experiment ±
28mmHg, experiment front and back no significant difference (P > 0.05).Experimental group has apparent therapeutic effect compared to the control group, and difference is extremely aobvious
It writes (P < 0.01).
Embodiment 2
It is fresh with 100kgHevea brasiliensisSeed is raw material, after drying shelling, prepares kernel 40kg.Kernel object
Material arrives 80-100 DEG C in heat, and then by static extruding, pressure 50MPa obtains 12kgHevea brasiliensisKind
The liposoluble substance of son.
With 10kgHevea brasiliensisThe lipoclastic of seed is raw material, and 10kg potassium hydroxide-ethanol solution is added
Saponification is carried out, the mass percent concentration of potassium hydroxide in ethanol is 22%.After saponification terminates, 0.005atm
Under vacuum condition, it is heated to 120 DEG C of recycling ethyl alcohol；5kg ethyl acetate is added later to extract as unsaponifiable matter extractant, separation
Upper layer of extraction liquid out is heated to 120 DEG C of recycling extractants, obtains the remaining liquid of 440g under 0.01atm vacuum condition
It is as of the inventionHevea brasiliensisThe unsaponifiable matter of the fatty contents of seed.
As control, the liposoluble substance for being derived from purple perilla seed using 10 kilograms under identical condition, prepares purple perilla as raw material
The unsaponifiable matter of the liposoluble substance of seed.
40 hypertensive patients are recruited, are randomly divided into two groups, every group of 20 people.First group (experimental group) takes orally substance of the present invention
Manufactured health food, dose are 1g/ days (with the meter of substance of the present invention in drug)；Second group (control group) oral purple perilla
Seed oil, oral dose are 1 gram/day.It is detected after 30 days oral.
Testing index is the diastolic pressure of patient.Experimental group systolic pressure is from 107 ± 16mmHg before experiment, after being reduced to experiment
76 ± 10mmHg, difference are extremely significant (P < 0.01)；108 ± 17mmHg of systolic pressure before control group is tested, 110 after experiment ±
19mmHg, experiment front and back no significant difference (P > 0.05).Experimental group has apparent therapeutic effect compared to the control group, and difference is extremely aobvious
It writes (P < 0.01).
Embodiment 3
It is fresh with 100kgHevea brasiliensisSeed is raw material, after drying shelling, prepares kernel 40kg.Kernel object
Material arrives 80-100 DEG C in heat, then passes through dynamic screw extrusion, and the screw extrusion time is 45 seconds or so, squeezes out 15kg seed
Liposoluble substance.
With 10kgHevea brasiliensisThe lipoclastic of seed is raw material, and 10kg potassium hydroxide-ethanol solution is added
Saponification is carried out, the mass percent concentration of potassium hydroxide in ethanol is 22%.After saponification terminates, 0.005atm
Under vacuum condition, it is heated to 120 DEG C of recycling ethyl alcohol；5kg ethyl acetate is added later to extract as unsaponifiable matter extractant, separation
Upper layer of extraction liquid out is heated to 120 DEG C of recycling extractants, obtains the remaining liquid of 450g under 0.01atm vacuum condition
It is as of the inventionHevea brasiliensisThe unsaponifiable matter of the fatty contents of seed.
As control, the liposoluble substance for being derived from maize germ using 10 kilograms is raw material, and under identical condition, preparation is beautiful
The unsaponifiable matter of the liposoluble substance of rice plumule.
A pair is with ovum same sex female twin, and the age 47 years old, height was 1.62 meters, and weight is 55 kilograms.Two people are usually quiet
Blood pressure is 145/95mmHg under breath state, and existing 15 years history is not taken medicine without special discomfort.
First (elder sister) in twins eats food made of material for lowering blood pressure disclosed by the invention, and amount is 2.0 grams/
Day (in terms of material for lowering blood pressure)；Made of the unsaponifiable matter of the liposoluble substance of second (younger sister) edible corn plumule in twins
Food, amount are 2.0 grams/day (in terms of the unsaponifiable matter of the liposoluble substance of maize germ).Repetition measurement tranquillization shape after one month
Blood pressure under state: the blood pressure of first is reduced to 130/80mmHg, and systolic pressure reduces 15mmHg, and diastolic pressure reduces 15mmHg；The blood pressure of second is still
It is so 145/95mmHg, does not reduce.
Embodiment 4
It is fresh with 100kgHevea brasiliensisSeed is raw material, after drying shelling, prepares kernel 40kg.Then will
After kernel carries out expanding treatment, it is put into the leaching container of sealing, the solvent of 2 times of weight is added.It (is boiled lower than solvent at 55 DEG C
Point) under condition and normal pressure, material is stirred and is mixed with solvent, material is allowed to come into full contact with solvent.It staticly settles later,
Solvent is leached, then allows solvent to volatilize under 100Pa vacuum condition 120 DEG C (being higher than solvent boiling point temperature), obtains 18kgHevea brasiliensisThe liposoluble substance of seed.
With 10 kgHevea brasiliensisThe lipoclastic of seed is raw material, and 10kg potassium hydroxide-ethanol solution is added
Saponification is carried out, the mass percent concentration of potassium hydroxide in ethanol is 22%.After saponification terminates, 0.005atm
Under vacuum condition, it is heated to 120 DEG C of recycling ethyl alcohol；5kg6 solvent is added later to extract as unsaponifiable matter extractant, separation
Upper layer of extraction liquid out is heated to 140 DEG C of recycling extractants, obtains the remaining liquid object of 460g under 0.005atm vacuum condition
Matter is of the inventionHevea brasiliensisThe unsaponifiable matter of the fatty contents of seed.
As control, the liposoluble substance for being derived from olive fruit using 10 kilograms under identical condition, prepares olive as raw material
The unsaponifiable matter of the liposoluble substance of fruit.
A pair is with ovum same sex female twin, and the age 69 years old, height was 1.55 meters, and weight is 58 kilograms.Two people are usually quiet
Blood pressure is 140/90mmHg under breath state, without special discomfort, is not taken medicine.
First (younger sister) in twins eats food made of material for lowering blood pressure disclosed by the invention, and amount is 3.0 grams/
Day (in terms of material for lowering blood pressure)；Food made of the unsaponifiable matter for the liposoluble substance that second (elder sister) in twins eats olive fruit
Object, amount are 3.0 grams/day (in terms of the unsaponifiable matter of the liposoluble substance of olive fruit).After one month under repetition measurement quiescent condition
Blood pressure: the blood pressure of first is reduced to 130/80mmHg, and systolic pressure reduces 10mmHg, and diastolic pressure reduces 10mmHg；The blood pressure of second remains as
140/90mmHg is not reduced.
Embodiment 5
It is fresh with 100kgHevea brasiliensisSeed is raw material, after drying shelling, prepares kernel 40kg.By kernel
After carrying out granulation processing, it is put into the supercritical extract container of sealing pressure resistance, carbon dioxide solvent is added, solvent quality is material
2 times of quality.At 35 DEG C, 10MPa(is more than the critical-temperature and critical pressure of solvent) under conditions of, material and solvent are carried out
It stirs and mixes, material is allowed to come into full contact with solvent.It staticly settles later, leaches solvent and then under room temperature at 25 DEG C subtract
Small pressure allows solvent to volatilize, obtains 18kg to normal pressure (0.1MPa)Hevea brasiliensisThe liposoluble substance of seed.
With 10kgHevea brasiliensisThe lipoclastic of seed is raw material, and 10kg potassium hydroxide-ethanol solution is added
Saponification is carried out, the mass percent concentration of potassium hydroxide in ethanol is 22%.After saponification terminates, 0.005atm
Under vacuum condition, it is heated to 120 DEG C of recycling ethyl alcohol；No. 6 solvents of 5kg are added later to extract as unsaponifiable matter extractant, separation
Upper layer of extraction liquid out is heated to 140 DEG C of recycling extractants, obtains the remaining liquid object of 450g under 0.005atm vacuum condition
Matter is of the inventionHevea brasiliensisThe unsaponifiable matter of the fatty contents of seed.
As control, the liposoluble substance for being derived from pumpkin seed using 10 kilograms is raw material, under identical condition, preparation south
The unsaponifiable matter of the liposoluble substance of melon seeds benevolence.
A pair is with ovum same sex female twin, and the age 45 years old, height was 1.53 meters, and weight is 56 kilograms.Two people are usually quiet
Blood pressure is 148/90mmHg under breath state, without special discomfort, is not taken medicine.
First (younger sister) in twins eats food made of material for lowering blood pressure disclosed by the invention, and amount is 1.5 grams/
Day (in terms of material for lowering blood pressure)；Made of the unsaponifiable matter of the liposoluble substance of second (elder sister) edible squash seed benevolence in twins
Food, amount are 1.5 grams/day (in terms of the unsaponifiable matter of the liposoluble substance of pumpkin seed).Repetition measurement tranquillization shape after one month
Blood pressure under state: the blood pressure of first is reduced to 135/80mmHg, and systolic pressure reduces 13mmHg, and diastolic pressure reduces 10mmHg；The blood pressure of second is still
It is so 148/90mmHg, does not reduce.
Embodiment 6:
It is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance is not saponified
Excipient, pelletizing press sheet is added in the ratio of the part and excipient weight ratio 1:1 or 1:2 in object.Tablet can be used as drug,
Health food or food.
Embodiment 7:
It is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance is not saponified
Object is wrapped in soft capsule material by the part, and routinely soft capsule is made in capsule preparations method.Soft capsule can be used as medicine
Product, health food or food.
Embodiment 8:
It is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance is not saponified
Object, with the part, in addition emulsifier, osmotic pressure regulator and water obtain emulsion for injection by high-pressure homogeneous emulsification.
Embodiment 9:
It is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance is not saponified
By the part, then tablet is made in object as follows:
Tablet:Hevea brasiliensisThe unsaponifiable matter 100mg of seed liposoluble substance
Appropriate starch
Appropriate corn pulp
Magnesium Stearate proper quantity
Preparation method: willHevea brasiliensisThe unsaponifiable matter of seed liposoluble substance is mixed with auxiliary agent, and sieving is being closed
It is uniformly mixed in suitable container, obtained granulating mixture tabletting.
Embodiment 10:
It is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance is not saponified
By the part, then soft capsule is made in object as follows:
Soft capsule:Hevea brasiliensisThe unsaponifiable matter 1000mg of seed liposoluble substance
Appropriate gelatin
Appropriate glycerol
Appropriate amount of water
Preparation method: gelatin, glycerol, which are put into distilled water, to impregnate makes gelatin expansion, softening, is then uniformly mixed, obtains
Capsule material glue.Prepared capsule material glue is taken out, is coated in flat plate surface, keeps thickness uniform, then with 90 DEG C or so
Temperature heating, evaporates surface moisture, becomes the cushion compound for having certain toughness, having certain elasticity.Finally with pelleting mold or
Automatic rotation rolling capsule machine, willHevea brasiliensisThe unsaponifiable matter (1000mg) of seed liposoluble substance is packed into soft capsule
Pi Zhong produces soft capsule.
Embodiment 11:
It is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance is not saponified
By the part, then emulsion for injection is made in object as follows:
Emulsion for injection:Hevea brasiliensisThe unsaponifiable matter 200g of seed liposoluble substance
Appropriate lecithin
Appropriate glycerol
Appropriate sodium chloride
Appropriate amount of water
Preparation method:, will according to formulaHevea brasiliensisThe unsaponifiable matter of seed liposoluble substance, lecithin are sweet
Oil mixing, adds water to 1000mL, adds appropriate sodium chloride adjustment osmotic pressure, high-pressure homogeneous emulsification, and 121 DEG C of sterilizings are down to room temperature, i.e.,
Obtain emulsion for injection.
Embodiment 12:
Tablet: it is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance is not
Saponified 10mg, lactose 180mg, starch 55mg, magnesium stearate 5mg；
Preparation method: it will be made of the invention by the method in embodiment 1-5Hevea brasiliensisThe fat-soluble object of seed
The unsaponifiable matter of matter, newborn sugar and starch mixing, are uniformly moistened with water, and the mixture after moistening is sieved and is dried, re-sieving adds
Enter magnesium stearate, then by mixture tabletting, every slice weight 250mg is of the inventionHevea brasiliensisSeed is fat-soluble
The unsaponifiable matter content of substance is 10mg.
Embodiment 13:
Capsule: it is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance
Unsaponifiable matter 2000g, gelatin 1000g, glycerol 500g, water 1000g；
Preparation method: by gelatin 1000g, glycerol 500g, being put into 1000g water to impregnate makes gelatin expansion, softening, and then stirring is mixed
It closes uniformly, obtains capsule material glue.Prepared capsule material glue is taken out, is coated in flat plate surface, keeps thickness uniform, then uses
90 DEG C or so of temperature heating, evaporates surface moisture, becomes the cushion compound for having certain toughness, having certain elasticity.Finally with pressure
Ball mold rotates rolling capsule machine automatically, willHevea brasiliensisThe unsaponifiable matter 1000mg of seed liposoluble substance is filled
Enter in soft capsule skin, soft capsule is made.Every soft capsule weighs 1.4g, of the inventionHevea brasiliensisSeed is fat-soluble
The unsaponifiable matter content of substance is 1000mg.
Embodiment 14:
Emulsion for injection: it is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance
Unsaponifiable matter 200g, glycerol 25g, lecithin 12g, water 1000g, sodium chloride 1g；
Preparation method: accurate weighing is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed rouge
Unsaponifiable matter 200g, glycerol 25g, the lecithin 12g of soluble substance, mixing add water to 1000mL, add sodium chloride, will permeate
Pressure is adjusted to 350mosm/kg H2O.High-pressure homogeneous emulsification obtains emulsion, and 121 DEG C of sterilizings are down to room temperature, aseptically
It is filled in the sterile glass vials of 250mL and encapsulates.Every bottle of emulsion for injection specification is 250mL, of the inventionHevea brasiliensisThe unsaponifiable matter content of seed liposoluble substance is 50g.
Embodiment 15:
Food: it is made of the invention by the method in embodiment 1-5Hevea brasiliensisSeed liposoluble substance is not
It is saponified, it is reconciled by the part and oil with common edible, is directly becoming food (edible oil)；
Preparation method: 1kg is made of the invention by the method in embodiment 1-5Hevea brasiliensisThe fat-soluble object of seed
The unsaponifiable matter of matter is added in 9kg soybean oil, obtains 10kg blending edible oil.By the filling glass at 500g of blending edible oil
Glass bottle, it is of the inventionHevea brasiliensisThe unsaponifiable matter content of seed liposoluble substance is 50g.
Claims (10)
1. plantHevea brasiliensisThe unsaponifiable matter of (para ruber) seed liposoluble substance, it is characterised in that should
Substance is prepared by the following method and obtains:
With freshHevea brasiliensis(para ruber) seed is that raw material prepares kernel, kernel after drying shelling
It is made by one or more of mechanical presses method, extraction method, supercritical extractionHevea brasiliensis(three
Leaf rubber tree) seed lipoclastic, then withHevea brasiliensisThe lipoclastic of (para ruber) seed is raw material,
Excessive potassium hydroxide-ethanol solution is added and carries out saponification, after saponification terminates, under vacuum conditions, heats back
Receive ethyl alcohol, later be added unsaponifiable matter extractant extracted, selected extractant be ether, ethyl acetate, n-hexane, No. 6 it is molten
One of agent isolates upper layer of extraction liquid, under vacuum conditions reheating, recycles extractant, and remaining liquid isHevea brasiliensisThe unsaponifiable matter of the fatty contents of (para ruber) seed.
2. containing the described in claim 1 of therapeutically effective amountHevea brasiliensis(para ruber) seed is fat-soluble
The unsaponifiable matter of substance and the pharmaceutical composition of pharmaceutically acceptable carrier.
3. health food, by described in claim 1Hevea brasiliensis(para ruber) seed liposoluble substance
Unsaponifiable matter and health food common carrier formed.
4. food, by described in claim 1Hevea brasiliensis(para ruber) seed liposoluble substance is not
Saponified and food common carrier is formed.
5. described in claim 1Hevea brasiliensisThe unsaponifiable matter of (para ruber) seed liposoluble substance exists
Application in the drug of preparation treatment hypertension.
6. application as claimed in claim 5, which is characterized in that describedHevea brasiliensis(para ruber)
The unsaponifiable matter of seed liposoluble substance is as the sole active agent in drug.
7. described in claim 1Hevea brasiliensisThe unsaponifiable matter of (para ruber) seed liposoluble substance exists
Application in the health food of preparation treatment hypertension.
8. application as claimed in claim 7, which is characterized in that describedHevea brasiliensis(para ruber)
The unsaponifiable matter of seed liposoluble substance is as sole active agent.
9. described in claim 1Hevea brasiliensisThe unsaponifiable matter of (para ruber) seed liposoluble substance exists
Prepare the application in the food of hypertensive patient.
10. application as claimed in claim 9, which is characterized in that describedHevea brasiliensis(Hevea rubber
Tree) seed liposoluble substance unsaponifiable matter as sole active agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711139122.9A CN109793790A (en) | 2017-11-16 | 2017-11-16 | A kind of substance of blood pressure lowering, using and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711139122.9A CN109793790A (en) | 2017-11-16 | 2017-11-16 | A kind of substance of blood pressure lowering, using and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109793790A true CN109793790A (en) | 2019-05-24 |
Family
ID=66555609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711139122.9A Pending CN109793790A (en) | 2017-11-16 | 2017-11-16 | A kind of substance of blood pressure lowering, using and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN109793790A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215059A (en) * | 1997-10-18 | 1999-04-28 | 李世泰 | Extration of steroid compound from rubber seeds |
-
2017
- 2017-11-16 CN CN201711139122.9A patent/CN109793790A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215059A (en) * | 1997-10-18 | 1999-04-28 | 李世泰 | Extration of steroid compound from rubber seeds |
Non-Patent Citations (4)
| Title |
|---|
| 王慧敏: "橡胶籽油的提取、精炼及其氧化稳定性研究", 《中国优秀硕士学位论文全文数据库工程科技Ι辑》 * |
| 王敬铭: "《中国树木文化源流》", 31 August 2014, 华中师范大学出版社 * |
| 詹益兴主编: "《绿色精细化工 天然产品制造法》", 31 January 2008, 科学技术文献出版社 * |
| 郭力 等: "《中药化学》", 31 August 2015, 北京医药科技出版社 * |
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Application publication date: 20190524 |
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