CN1202866C - Gastrointestinal contrast agent containing biomass - Google Patents
Gastrointestinal contrast agent containing biomass Download PDFInfo
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- CN1202866C CN1202866C CN 03112182 CN03112182A CN1202866C CN 1202866 C CN1202866 C CN 1202866C CN 03112182 CN03112182 CN 03112182 CN 03112182 A CN03112182 A CN 03112182A CN 1202866 C CN1202866 C CN 1202866C
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- contrast agent
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Abstract
The present invention relates to a gastrointestinal contrast agent containing biomass, which belongs to the technical field of medical x-ray gastrointestinal contrast agents. The present invention is characterized in that the gastrointestinal contrast agent is formed by that traditional contrast agents which use high-absorption X-ray materials [A] of nonhazardous metallic salt (such as barium sulfate, etc.) as main materials are added with low-absorption X-ray materials [B] of a biomass resource of superfine powder, or/and assistants [C] (adhesion assistants, proportional assistants, flavouring assistants, etc.), defoamers [D] (silicone, etc.) and water [E]. [A]+[B]+[C]+[D]+[E]=(0.5 to 99.5%) +(0.5 to 99.5%) +(0 to 5%)+(0 to 1%)+(0 to 99%)=100%(w/w). The present invention can develop well, can strengthen visualization effects and can promote gastrointestinal peristalsis. The gastrointestinal contrast agent is an ideal novel stomach intestine contrast agent having an environment protecting conception.
Description
(1) technical field:
The present invention relates to a kind of gastrointestinal contrast agent that contains biomass, be mainly used in medical oral X-Ray gastrointestinal series, belong to medical and make the field.
(2) background technology:
It is material that X-Ray gastrointestinal contrast agent in the past mainly is to use the material fine powder of the high X-Ray of absorption of metallic salt of nonhazardous in gastrointestinal tract such as barium sulfate, is aided with the powdery agent of seasonings such as flavouring agent, and the furnishing pulpous state is drunk or coloclysis uses.Typically as barium meal: " medicinal barium sulfate 100～120g adds replacements such as water 200ml and the also available in right amount Resina persicae slurry of arabic gum, medical solubility carboxymethyl cellulose, tragacanth, Pseudobulbus Bletillae (Rhizoma Bletillae) glue." (" medical treatment and nursing technical operation standard ", Lou Fangcen etc., soldier publishing house of the Chinese People's Liberation Army, Beijing, 1982.P.1568).
Traditional barium meal is effective, but also have some problems be barium sulfate (waiting the high X-Ray of absorption of the metallic salt material of nonhazardous) fine powder concentration is higher, proportion than Da Yi form precipitation, suspend bad or colloid viscous inconvenient eating or mouthfeel bad; Can not effectively promote gastrointestinal peristalsis after entering digestive tract, thereby descending not smooth, action of enterogastric function and condition are gone far mutually during particularly with actual food existence, and contradiction is more outstanding during the all-digestive tract radiography; And " can cause constipation sometimes behind the gastrointestinal series " (" clinical medicine handbook dragon Kun etc., Golden Shield publishing house, Beijing, 1993.P.957); Because " concentration " is higher relatively, suspension stability is inevitable relatively poor, is easy to precipitation, though can observe domain of dependence by extruding, still can influence imaging sometimes; Because barium meal its moisture in descending process in the past little by little is absorbed, during to the intestinal hypomere, only the barium sulfate powder composition of remaining barium meal is main, and becoming the powder mass group of scleroma easily, volume and distributivity, coating are relatively poor, and be unsatisfactory to the radiography effect of intestinal, this is one of maximum problem, careful for intestinal is observed, just have to rely on come again from the bottom barium coloclysis affirmation can not, get half the result with twice the effort; In addition, the barium sulfate powder X-Ray resistance shelves rate height of high level, the imaging contrast is big, though favourable one side be qualitative accurately, effect is better, its above-mentioned negative effect also increases simultaneously, another side be exactly in operation and imaging process so high concentration be not necessity and necessary, the increase of its concentration and dwindling of volume when the intestinal hypomere, ductility, coating further reduce, and have had influence on radiography efficient, can not excessive demand form stereovision.Imaging, radiography effect are not fine.
(3) summary of the invention:
The present invention is directed to the deficiencies in the prior art, a kind of medical new oral X-Ray gastrointestinal contrast agent is provided, specifically is a kind of gastrointestinal contrast agent that contains biomass.Be characterised in that low absorption X-Ray material [B] that the high biomass that absorb X-Ray material [A] and its fineness superfines in maximum dimension≤100 micron of the metallic salt of 0.5～1.0 micron of, fineness that gastrointestinal contrast agent uses by being applicable to are originated or and bonding, mediation, seasoning adjuvant [C], defoamer silicone oil [D] and water [E] form, wherein the percentage by weight of each component is as follows:
[A]：0.5～99.5％
[B]：0.5～99.5％
[C]：0～5％
[D]：0～1％
[E]：0～99％。
Of the present invention by traditional metallic salt that is applicable to that gastrointestinal contrast agent uses high absorb X-Ray material [A] be meant medicinal barium sulfate, citric acid osmium (bismuth) potassium, other, and compound, compound.
Obviously, the present invention adds " diluent " traditional with high absorption of nonhazardous metallic salt (as barium sulfate etc.) in the contrast agent that X-Ray material [A] be a main material, what is called " diluent " mainly is that the low absorption X-Ray material [B] by the biogenetic derivation of superfines is meant biogenetic derivation, the cellulose that can not be digested and assimilated, hemicellulose, pectic substance, the chitin class, or other biomass class normal-temperature water is insoluble or indissoluble material elaboration crude product or analog (as epidermises such as corn), the superfines that can not be digested and assimilated etc. single or and compound, composite composition; Its fineness is in maximum dimension≤100 micron, and promptly its maximum dimension size is roughly below people's naked eyes resolution.This kind " diluent " and traditional radiography main material, with the nonhazardous metallic salt (as barium sulfate etc., the medical requirement standard that specification can be used by general tradition; In case of necessity, adopt granularity, someone propose particle requirement be 0.5～1.0 micron for well." clinicist's diagnosis and treatment pandect ", Wang Yucai etc., China Science Tech Publishing House, Beijing, 1992.P.1002) when high absorption X-Ray material [A] is composite, in moisture [E] and bonding, be in harmonious proportion, under the combineds effect such as [C] of adjuvant such as seasoning, the high X-Ray material [A] that absorbs of the less nonhazardous metallic salt of granularity fineness (as barium sulfate etc.) is even, fully " parcel " is in granularity, fineness is similar generally to be granularity, around the low absorption X-Ray material [B] in the biomass source that fineness is bigger, radiography well, fully " dilution " again, " dispersion " contrast agent, can not influence the imaging performance of radiography effect and digestive tract inner surface fine structure again, because list structure is all less than general cell (7～70 microns) in the general digestive tract, and the resolution of people's naked eyes is at 70～100 microns, so can not influence the imaging and the radiography of slight part, and, also can strengthen the radiography effect owing to stick effect.
The low absorption X-Ray material [B] in biomass of the present invention source be meant the biomass source medical, food grade the cellulose that can not be digested and assimilated, hemicellulose, pectic substance, chitin class or other biomass class normal-temperature water is insoluble or indissoluble material elaboration, crude product, single or and compound, the compound of the superfines of fineness in maximum dimension≤100 micron.
Some method for makings of the low absorption X-Ray material [B] that can not be digested and assimilated fully in biomass source:
(1), powder
1, full wheat bran: whether clean two kinds, levigate up to standard.
2, decompose the full wheat bran of phytic acid, culture propagation decomposes phytic acid, whether cleans two kinds, and is levigate.
3, refining wheat bran, the insulation enzymolysis is removed part or all of protein, starch and phytic acid, and is levigate
4, Cortex beans
5, Rhizoma Dioscoreae esculentae powder: the Rhizoma Dioscoreae esculentae peeling, cook, section, drying, to pulverize, screening obtains less than 80 purpose powder.
(2), beans, serosity, water content is suitable promptly to be.
1, Rhizoma Dioscoreae esculentae peeling cooks, making beating, and colloid mill, screening fineness the largest particles diameter is less than 100 microns.
2, Fructus Crataegi peeling, enucleation cook, making beating, and colloid mill, screening fineness the largest particles diameter is less than 100 microns.
The low absorption X-Ray material [B] that can not be digested and assimilated fully in biomass of the present invention source is that the insoluble or indissoluble material of normal-temperature water is the higher cellulose of purity, hemicellulose, pectic substance or chitin etc.But be the consideration that reduces cost, its crude product or analog (as epidermises such as corn) also can adopt.Generally can be to derive from seed skin such as corn,, also can substitute wholly or in part with dried powder such as the fruit peel of some careful processing or fruit and tuber, tuber or its serosity as the careful processing powder of bran coat, Semen Pisi sativi and soybean cover etc.All processing, key are that its granularity must requirement according to the invention.In many cases, in order fully to reach and pursue the relative amount of the insoluble or slightly solubility of the normal-temperature water of low absorption X-Ray material [B] in biomass of the present invention source, indigestible property material, need some technologies to remove seed skins such as general corn, as the solvable and digestibility material in bran coat, Semen Pisi sativi and the soybean cover etc.The for example protein that can digest and assimilate of the general human body that still contains more amount, starch etc., institute's fibre-bearing is generally only about 25～35%, improve the relative amount of its edible fiber class material as desire, need carry out some and handle, for example fully rinse materials such as protein on the Semen setariae bran coat, starch; And general enzymatic treatment is removed materials such as protein, starch, Deng its edible fiber class material is increased, this technology belongs to routine techniques, also can be with reference to the similar preparation method according to the edible fiber of mentioning among U.S. Pat 4765994A and the US4774096A.
The macromolecular material rubber cement class in natural resin glue such as that bonding of the present invention, mediation, seasoning adjuvant [C] are meant is medical, the alginate jelly of the flavouring agent of food grade, sweeting agent, acidic flavoring agent, antiseptic and medical, food grade, xanthan gum, arabic gum, Resina persicae slurry, solubility carboxymethyl cellulose, tragacanth, Pseudobulbus Bletillae (Rhizoma Bletillae) glue natural biomass source, or the macromolecular material medical, food grade in other abiotic sources disperses the binding agent auxiliary element.
That defoamer such as silicone oil of the present invention [D] are meant is medical, food grade silicone oil and other are medical, the food grade surfactant is formed.
That water used in the present invention [E] is meant is medical, the medical aseptic water or the drinking water that meet sanitary index of food grade.
The gastrointestinal contrast agent that contains biomass provided by the present invention also can be used with traditional barium meal agent, barium colloidal suspension agent.Promptly at first use an amount of traditional good barium colloidal suspension agent of barium sulfate high concentration, end denseness, coating, after upper digestive tract (mainly being that membranous part grades) part necessarily observed, then use existing traditional barium agent characteristics, but contain the gastrointestinal contrast agent that contains biomass provided by the present invention that more solid content (superfines of biomass class material etc.) concentration is lower, have larger volume.In general, adjust formula components, the institute that the gastrointestinal contrast agent that contains biomass provided by the present invention all can reach traditional barium agent produces effect, and satisfies all requirements.
Other can add gas generating agent as the case may be by general routine, metoclopramide, sting beautiful jade, Folium Sennae, phenolphthalein (phenolphthalein), etc.And (with materials such as normal saline) osmotic pressure is regulated in attention.
Product Status of the present invention has one of three kinds of primitive forms, described three kinds of primitive forms are respectively: the powdery product that use after 1. water is in harmonious proportion, 2. directly use the beans paste product of edible or suitable thin up use, the paste shape product that directly eat when 3. available.
All formula material final products are all answered degerming, sterilization and harmless treatment.Method for disinfection uses radiation such as heating, Cobalt 60 or the like, can select for use flexibly according to the condition of production.
(4) specific embodiment:
Below several embodiment, all meet basic recipe, the formulation optimization in its scope.
Embodiment 1. powdery product: in use medical personnel according to circumstances with require water to be in harmonious proportion.
Barium sulfate 20～70%, wheat bran (or bran coat etc., the processing through removing protein and starch or not) fine powder 20～70%, gummi arabicum pulveratum 0.5～1.5%, Icing Sugar 8～9%, acidic flavoring agent and essence are an amount of.
In above scope, powdery product embodiment is: barium sulfate 60%, wheat bran fine powder 30%, gummi arabicum pulveratum 1%, Icing Sugar 8.2%, 0.8% citric acid, essence are an amount of.Transfer concentration 50～80% (w/w or w/v), once oral its 100～250g according to water such as individual tastes during use.As be the barium coloclysis, flavoring agent such as Icing Sugar and citric acid can be cancelled or cut down according to the circumstance, and the former two can drink and add, according to the use amount 150～300g that follows the doctor's advice of situation at that time.
Embodiment 2. powdery product: in use medical personnel according to circumstances with require water to be in harmonious proportion.
Barium sulfate 20～70%, wheat bran (or bran coat etc., the processing through removing protein and starch or not) fine powder 20～70%, gummi arabicum pulveratum 0.5～1%, haw berry powder 5～9%, sweeting agent, acidic flavoring agent and essence are an amount of.
In above scope, this kind powdery product embodiment is: barium sulfate 60%, wheat bran fine powder 30%, gummi arabicum pulveratum 1%, haw berry powder 9%, cyclamate and essence are an amount of.Transfer concentration 50～80% (w/w or w/v) according to individual taste water during use, oral its 100～250g follows the doctor's advice once.As be the barium coloclysis, the former two drinks and adds (the surplus cancellation), is 150～300g according to the feelings use amount.
Embodiment 3. powdery product: in use medical personnel according to circumstances with require water to be in harmonious proportion.
Barium sulfate 20～70%, sweet potato flour fine powder 20～70%, sweeting agent, acidic flavoring agent and essence are an amount of.
In above scope, this kind powdery product embodiment is: barium sulfate 64%, Rhizoma Dioscoreae esculentae fine powder 36%, cyclamate and essence are an amount of.Transfer concentration 50～80% (w/w or w/v) according to individual taste water during use, oral its 100～250g follows the doctor's advice once.As be the barium coloclysis, the former two drinks and adds (the surplus cancellation), use amount 150～300g.
Embodiment 4. beans paste product: directly use (or edible), or suitably thin up uses.
Barium sulfate 20～60%, wheat bran (or bran coat etc., the processing through removing protein and starch or not) fine powder 20～50%, gummi arabicum pulveratum 0.5～1.5%, pulp 10～15%, water 10～15%, Icing Sugar 8～9%, acidic flavoring agent, antiseptic and essence are an amount of.
In above scope, beans paste product embodiment is: barium sulfate 50%, wheat bran fine powder 25%, gummi arabicum pulveratum 1%, pulp 10%, water 5%, Icing Sugar 8%, 0.8% citric acid, potassium sorbate 0.1%, essence an amount of (w/w or w/v).Add suitable quantity of water during use again and transfer, oral until being suitable for.General one time oral dose 120～300g follows the doctor's advice.
Embodiment 5. beans paste product: directly use (or edible), or suitably thin up uses.
Barium sulfate 20～60%, Rhizoma Dioscoreae esculentae fine powder 20～50%, gummi arabicum pulveratum 0.5～1.5%, pulp 10～15%, water 10～15%, Icing Sugar 8～9%, acidic flavoring agent, antiseptic and essence are an amount of.
In above scope, this kind beans paste product embodiment is: barium sulfate 50%, Rhizoma Dioscoreae esculentae fine powder 25%, gummi arabicum pulveratum 1%, pulp 10%, water 5%, Icing Sugar 8%, 0.8% citric acid, potassium sorbate 0.1%, essence an amount of (w/w or w/v).Add suitable quantity of water during use again and transfer, oral until being suitable for.General one time oral dose 120～300g follows the doctor's advice.
Embodiment 6. paste shape product: its water content is the highest, and is directly edible when available substantially, during owing to placement sedimentation may take place, and can shake up during use as far as possible.
Barium sulfate 20～60%, wheat bran (or bran coat etc., the processing through removing protein and starch or not) fine powder 20～30%, gummi arabicum pulveratum 0.5～1.5%, pulp 10～15%, water 20～35%, Icing Sugar 8～9%, acidic flavoring agent, antiseptic and essence are an amount of.
In above scope, paste shape product embodiment is: barium sulfate 40%, wheat bran fine powder 20%, gummi arabicum pulveratum 1%, pulp 10%, Icing Sugar 8%, 0.8% citric acid, potassium sorbate 0.05%, water 20%, essence an amount of (w/w or w/v).Generally once oral its 120～500g follows the doctor's advice.
Embodiment 7. paste shape product:
Barium sulfate 20～60%, Rhizoma Dioscoreae esculentae fine powder 20～30%, gummi arabicum pulveratum 0.5～1.5%, pulp 10～15%, water 20～35%, Icing Sugar 8～9%, acidic flavoring agent, antiseptic and essence are an amount of.
In above scope, paste shape product embodiment is: barium sulfate 40%, Rhizoma Dioscoreae esculentae fine powder 20%, gummi arabicum pulveratum 1%, pulp 10%, Icing Sugar 8%, 0.8% citric acid, potassium sorbate 0.05%, water 20%, essence an amount of (w/w or w/v).Generally once oral 120～500g follows the doctor's advice.
Claims (6)
1, a kind of gastrointestinal contrast agent that contains biomass, it is characterized in that low absorption X-Ray material [B] and/or bonding, mediation, seasoning adjuvant [C], defoamer silicone oil [D] and water [E] that the high biomass that absorb X-Ray material [A] and the fineness superfines in maximum dimension≤100 micron of the metallic salt of 0.5～1.0 micron of, fineness that gastrointestinal contrast agent uses by being applicable to are originated forms, wherein the percentage by weight of each component is as follows:
[A]：0.5～99.5％
[B]：0.5～99.5％
[C]：0～5％
[D]：0～1％
[E]：0～99％。
2, the gastrointestinal contrast agent that contains biomass according to claim 1 is characterized in that the high X-Ray material [A] that absorbs of described metallic salt is meant barium sulfate, citric acid osmium potassium, and compound, compound.
3, the gastrointestinal contrast agent that contains biomass according to claim 1, the low absorption X-Ray material [B] that it is characterized in that described biomass source is meant medical, the cellulose that can not be digested and assimilated of food grade, hemicellulose, pectic substance, the chitin class in biomass source, or other biomass class normal-temperature water is insoluble or indissoluble material elaboration crude product.
4, the gastrointestinal contrast agent that contains biomass according to claim 1, it is characterized in that bonding, mediation, seasoning adjuvant [C] are meant medical, the flavouring agent of food grade, sweeting agent, acidic flavoring agent, antiseptic, and the rubber cement in the alginate jelly of medical, food grade, xanthan gum, arabic gum, Resina persicae slurry, solubility carboxymethyl cellulose, tragacanth, Pseudobulbus Bletillae (Rhizoma Bletillae) glue natural biomass source, or the macromolecular material medical, food grade in other abiotic sources disperses the binding agent auxiliary element.
5, the gastrointestinal contrast agent that contains biomass according to claim 1 is characterized in that water [E] is meant the medical aseptic water or the drinking water that meet sanitary index medical, food grade.
6, according to claim 1 or 2 or 3 or the 4 or 5 described gastrointestinal contrast agents that contain biomass, it is characterized in that Product Status has one of three kinds of primitive forms, described three kinds of primitive forms are respectively: the powdery product that use after 1. water is in harmonious proportion, 2. directly use the beans paste product of edible or suitable thin up use, the paste shape product that directly eat when 3. available.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03112182 CN1202866C (en) | 2003-04-23 | 2003-04-23 | Gastrointestinal contrast agent containing biomass |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03112182 CN1202866C (en) | 2003-04-23 | 2003-04-23 | Gastrointestinal contrast agent containing biomass |
Publications (2)
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| CN1444997A CN1444997A (en) | 2003-10-01 |
| CN1202866C true CN1202866C (en) | 2005-05-25 |
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| CN 03112182 Expired - Fee Related CN1202866C (en) | 2003-04-23 | 2003-04-23 | Gastrointestinal contrast agent containing biomass |
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| CN (1) | CN1202866C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100356983C (en) * | 2005-11-18 | 2007-12-26 | 山东大学 | Biotechnological treating method of biomass for stomach intestine contrast-media |
| CN101496905B (en) * | 2009-02-27 | 2010-09-15 | 莱芜钢铁集团有限公司医院 | Marker for function check of stomach and intestine and preparation method thereof |
| CN103948945B (en) * | 2014-05-04 | 2016-04-27 | 青岛市中心医院 | A kind of capsule barium meal and preparation method thereof |
| US9989482B2 (en) * | 2016-02-16 | 2018-06-05 | General Electric Company | Methods for radiographic and CT inspection of additively manufactured workpieces |
| CN109540936A (en) * | 2019-01-11 | 2019-03-29 | 大连大学附属中山医院 | It is a kind of for high-resolution ct and the room temperature contrast agent of x-ray artery, vein or pipeline and preparation method thereof |
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2003
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