CN1201735C - 分枝杆菌抑制剂 - Google Patents

分枝杆菌抑制剂 Download PDF

Info

Publication number
CN1201735C
CN1201735C CNB99808283XA CN99808283A CN1201735C CN 1201735 C CN1201735 C CN 1201735C CN B99808283X A CNB99808283X A CN B99808283XA CN 99808283 A CN99808283 A CN 99808283A CN 1201735 C CN1201735 C CN 1201735C
Authority
CN
China
Prior art keywords
dione
nonyl
group
ethyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB99808283XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1308532A (zh
Inventor
M·巴尔加人内什
K·埃蒂拉
B·甘古利
R·亚纳基拉曼
P·卡乌
R·卡希帕拉
S·南丹
R·P·穆鲁加潘
N·拉马钱德兰
B·文卡特拉曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9802118A external-priority patent/SE9802118D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1308532A publication Critical patent/CN1308532A/zh
Application granted granted Critical
Publication of CN1201735C publication Critical patent/CN1201735C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB99808283XA 1998-05-05 1999-05-03 分枝杆菌抑制剂 Expired - Fee Related CN1201735C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN969/MAS/1998 1998-05-05
IN969/MAS/98 1998-05-05
IN969MA1998 1998-05-05
SE9802118A SE9802118D0 (sv) 1998-06-15 1998-06-15 Mycobacterial inhibitors
SE98021181 1998-06-15

Publications (2)

Publication Number Publication Date
CN1308532A CN1308532A (zh) 2001-08-15
CN1201735C true CN1201735C (zh) 2005-05-18

Family

ID=26324850

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB99808283XA Expired - Fee Related CN1201735C (zh) 1998-05-05 1999-05-03 分枝杆菌抑制剂

Country Status (14)

Country Link
US (1) US6476053B1 (https=)
EP (1) EP1075261B1 (https=)
JP (1) JP2002518324A (https=)
KR (1) KR20010043322A (https=)
CN (1) CN1201735C (https=)
AT (1) ATE322898T1 (https=)
AU (1) AU739140B2 (https=)
BR (1) BR9910185A (https=)
CA (1) CA2330667A1 (https=)
DE (1) DE69930844T2 (https=)
IL (1) IL139144A0 (https=)
NO (1) NO20005548L (https=)
NZ (1) NZ507620A (https=)
WO (1) WO1999065483A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107033060A (zh) * 2017-05-04 2017-08-11 浙江工业大学 一种n‑取代顺丁烯二酰亚胺类化合物及其制备与抗菌应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002350115A1 (en) 2001-11-01 2003-05-12 Spectrum Pharmaceuticals, Inc. Medical compositions for intravesical treatment of bladder cancer
KR20080034944A (ko) * 2005-08-19 2008-04-22 아스트라제네카 아베 결핵 치료용 피라졸론 유도체
GB0520368D0 (en) * 2005-10-06 2005-11-16 Univ Aston Antibacterial pyrrols
EP2373617B1 (de) 2008-12-04 2015-02-25 Basf Se Mischungen aus itaconsäure oder itaconsäurederivaten und primären aminen zur herstellung von 1,3- und 1,4-alkylmethylpyrrolidonen
CA3009323C (en) * 2015-12-23 2023-01-24 Henkel Ag & Co. Kgaa Metal working fluid
CN111465611B (zh) * 2017-12-01 2024-10-11 古德T细胞有限公司 预防或治疗脱发的组合物
CN119569636B (zh) * 2024-10-22 2026-03-27 南京吉星生物技术开发有限公司 一种吡咯啉二酮类化合物及其制备方法和杀菌剂应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883342A (en) * 1973-04-13 1975-05-13 Akzona Inc Plant growth regulators

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107033060A (zh) * 2017-05-04 2017-08-11 浙江工业大学 一种n‑取代顺丁烯二酰亚胺类化合物及其制备与抗菌应用
CN107033060B (zh) * 2017-05-04 2020-01-14 浙江工业大学 一种n-取代顺丁烯二酰亚胺类化合物及其制备与抗菌应用

Also Published As

Publication number Publication date
NO20005548L (no) 2000-12-04
EP1075261A1 (en) 2001-02-14
JP2002518324A (ja) 2002-06-25
NO20005548D0 (no) 2000-11-03
DE69930844D1 (de) 2006-05-24
DE69930844T2 (de) 2006-12-28
CA2330667A1 (en) 1999-12-23
ATE322898T1 (de) 2006-04-15
BR9910185A (pt) 2001-01-09
EP1075261B1 (en) 2006-04-12
US6476053B1 (en) 2002-11-05
IL139144A0 (en) 2001-11-25
AU739140B2 (en) 2001-10-04
WO1999065483A1 (en) 1999-12-23
KR20010043322A (ko) 2001-05-25
NZ507620A (en) 2003-05-30
CN1308532A (zh) 2001-08-15
AU4304199A (en) 2000-01-05

Similar Documents

Publication Publication Date Title
CN1025999C (zh) 咪唑并[4，5-b]喹啉氧烷酰胺的制备方法
CN1056373C (zh) 含氮杂环类化合物的氟代烷氧基苄氨基衍生物的制备方法
CN1178912C (zh) 旋转异构酶活性的小分子抑制剂
CN1090188C (zh) 新的苯并萘啶类化合物
CN1279900C (zh) 用于睡眠障碍的加巴喷丁类似物
CN1202107A (zh) 选择性β3肾上腺素兴奋剂
CN1088582A (zh) 碱式季酰胺，其制备方法及其药物组合物
CN1214043A (zh) 苄基(亚苄基)-内酰胺衍生物,它们的制备以及作为5-ht1a和/或5-ht1d受体的选择性拮抗剂(激动剂)的用途
CN1404469A (zh) 2－氧代－1－吡咯烷衍生物、其制备方法和用途
CN1044811A (zh) 杂环化合物
CN1635892A (zh) 齐拉西酮的控制合成及其组合物
HK1046283A1 (en) Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives
CN1083059A (zh) 3-哌啶甲基羧酸酯取代的吲哚
CN85105673A (zh) 制备α-芳基-4-(4，5-二氢-3，5-二氧-1，2，4-三嗪-2(3H)基)-苯乙腈的方法
CN1201735C (zh) 分枝杆菌抑制剂
CN1062349A (zh) 用作药物的3-取代的呱啶类
CN1794985A (zh) 氮杂双环衍生物作为毒蕈碱受体拮抗剂
CN1098103A (zh) 新型吡啶酮羧酸衍生物
CN1113240A (zh) 噁唑烷酮衍生物的制备方法
CN1168716C (zh) 光学活性四氢苯并吲哚衍生物
CN1706824A (zh) 作为ccr5拮抗剂的化合物
CN1043990C (zh) 咪唑啉酮衍生物、其酸的加成盐及老年痴呆症的治疗药物
CN1099752A (zh) 新型酰氨烷基-和亚氨烷基-哌嗪
CN1155570C (zh) 新的氰基-吲哚5-羟色胺再摄取抑制剂化合物、其制备方法和含有它们的药物组合物
CN1827634A (zh) 甘草酸及甘草次酸的硝酸酯衍生物及其医药用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050518

Termination date: 20100503