CN1200928A - Sugar-less particles for treating infant's cold and preparation method therefor - Google Patents
Sugar-less particles for treating infant's cold and preparation method therefor Download PDFInfo
- Publication number
- CN1200928A CN1200928A CN 97107520 CN97107520A CN1200928A CN 1200928 A CN1200928 A CN 1200928A CN 97107520 CN97107520 CN 97107520 CN 97107520 A CN97107520 A CN 97107520A CN 1200928 A CN1200928 A CN 1200928A
- Authority
- CN
- China
- Prior art keywords
- preparation
- time
- cold
- sugar
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 239000002245 particle Substances 0.000 title description 3
- 239000000843 powder Substances 0.000 claims abstract description 7
- 239000008187 granular material Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000010231 banlangen Substances 0.000 claims description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000341 volatile oil Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000007598 dipping method Methods 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 201000009240 nasopharyngitis Diseases 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 9
- 206010022000 influenza Diseases 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 4
- 206010037660 Pyrexia Diseases 0.000 abstract description 3
- 206010011224 Cough Diseases 0.000 abstract description 2
- 206010019233 Headaches Diseases 0.000 abstract description 2
- 206010028748 Nasal obstruction Diseases 0.000 abstract description 2
- 206010039101 Rhinorrhoea Diseases 0.000 abstract description 2
- 231100000869 headache Toxicity 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 241000222666 Boerhavia diffusa Species 0.000 abstract 1
- 241000587240 Cynanchum Species 0.000 abstract 1
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 241000334160 Isatis Species 0.000 abstract 1
- 206010068319 Oropharyngeal pain Diseases 0.000 abstract 1
- 201000007100 Pharyngitis Diseases 0.000 abstract 1
- 235000011751 Pogostemon cablin Nutrition 0.000 abstract 1
- 208000036071 Rhinorrhea Diseases 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 15
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 3
- 235000021050 feed intake Nutrition 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001387 anti-histamine Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000005180 public health Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 208000036649 Dysbacteriosis Diseases 0.000 description 1
- 208000027244 Dysbiosis Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003291 chlorphenamine Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 208000009146 rhinoscleroma Diseases 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The preparation method of pure Chinese medicinal preparation (sugar-free type) for curing infantile common cold and epidemic influenza is characterized by that it is a powder preparation made up by using the Chinese medicinal materials of patchouli, forsythia fruit, isatis root and baiwei cynanchum root, etc. as raw materials through a certain preparation process, and mainly is used for curing infantile common cold and epidemic influenza and concomitant symptoms of fever, cough, headache, nasal obstruction, rhinorrhea and sore-throat, etc, and has no obvious side effect. Its total effective rate is 79.6% and total active rate is 98.1%.
Description
The present invention relates to treat the xiao'er ganmao granules (Sugarless type) and the preparation method thereof of infantile common cold, influenza.
The medicine of treatment infantile common cold mostly is NSAID (non-steroidal anti-inflammatory drug), antihistaminic and antibiotics medicine at present, and these medicine side effect are more common, the serious adverse effects in addition that has.As acetaminophen, though better analgesic, analgesic activity are arranged, usually can cause untoward reaction, as gastrointestinal upset, allergic dermatitis.Antihistaminic such as chlorphenamine etc. often cause drowsiness.The uncertain therapeutic efficacy that cures cold of antibiotics medicine, and easily cause Resistant strain generation and dysbacteriosis, anaphylaxis etc.Chinese patent drugs for treatment flu determined curative effect is generally acknowledged, but some Chinese patent medicines such as KANGBINGDU CHONGJI etc., and because of sugar content is big, each taking dose big (being more than the 12g), dissolubility are relatively poor, so the child administration inconvenience.
It is good to the purpose of this invention is to provide a kind of safety, determined curative effect, and dose is few, the preparation method of the pharmaceutical preparation of treatment infantile common cold.
The present invention is according to theory of Chinese medical science, chooses multiple genuine medicinal materials, reasonable formula, the refining sugar-free granule that forms of the modern advanced pharmaceutical technology of employing.This product is domestic exclusive development, the pure Chinese medicinal preparation that the children's cold of producing without competition is used (seeing novelty assessment report adnexa 1).Medicine consists of Herba Pogostemonis, Flos Chrysanthemi, Fructus Forsythiae, Folium Isatidis, Cortex Lycii, Radix Cynanchi Atrati, Herba Menthae, Radix Rehmanniae, Radix Isatidis.Herba Pogostemonis dispelling wind to relieve the exterior syndrome, eliminating turbid pathogen with aromatics in the side, the Radix Isatidis heat-clearing and toxic substances removing, two medicine mutual reinforcements between are usefulness, dispel the our primary symptom cause of disease, as principal agent.Minister is with Flos Chrysanthemi, Herba Menthae dispelling wind, clearing away heat and expelling pathogen in the exterior, at the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, give exopathogen with the effect of outlet with Fructus Forsythiae, Folium Isatidis, Radix Isatidis heat-clearing and toxic substances removing, the sweet cold product Gypsum Fibrosum of compatibility and Cortex Lycii, Bai Wei, the Radix Rehmanniae of clearing away heat and cooling blood effect, at diseases such as heatings, block the change of disease of disease, full side selects YAOJING good, and reasonable recipe is gathered the merit of clearing away heat and expelling pathogen in the exterior altogether.Modern pharmacological research confirms, that this product has is antibiotic, antiviral, analgesic, antitussive, antiinflammatory action, flu, influenza are had the good curing effect, be applicable to infantile common cold, influenza, disease is seen: diseases such as fever, cough, headache, nasal obstruction, watery nasal discharge, sneeze, laryngopharynx swelling and pain.Show through Ministry of Public Health clinical pharmacology base Hospital Affiliated To Chengdu Traditional Chinese Medicine Univ and the clinical verification of Chengdu children's hospital: xiao'er ganmao granules is effective Chinese medicine preparation of treatment infantile common cold, total obvious effective rate is 79.6%, total effective rate is 98.1%, non-evident effect is effective Chinese medicine preparation for the treatment of infantile common cold (upper respiratory tract infection) at present.
We investigate the medicine that is used for the treatment of infantile common cold on the market, and in conjunction with clinician's practical experience, have selected this compound recipe is prepared into granule, and concrete preparation method is
1.[prescription] Herba Pogostemonis 75g Flos Chrysanthemi 75g Fructus Forsythiae 75g Folium Isatidis 125g Radix Isatidis 75g
Radix Rehmanniae 75g Cortex Lycii 75g Radix Cynanchi Atrati 75g Herba Menthae 50g Gypsum Fibrosum 125g
2.[method for making] above ten flavors, Radix Rehmanniae, Radix Cynanchi Atrati, Cortex Lycii, Gypsum Fibrosum (100g) decoct with water secondary, and 3 hours for the first time, 1 hour for the second time, collecting decoction filtered; Flos Chrysanthemi, Folium Isatidis hot dipping secondary, 2 hours for the first time, 1 hour for the second time, merge leachate, filter; Herba Pogostemonis, Herba Menthae, Fructus Forsythiae extract volatile oil, and its aqueous solution filters, and filtrate and above two liquid merge, and being concentrated into relative density is the clear paste of 1.10～1.20 (50 ℃); Gypsum Fibrosum 25g, Radix Isatidis powder are broken into fine powder.1 part of 1 part of qinghuo reagent, lactose and fine powder, mixing is put and is made granule in the one-step-granulating method, sprays into volatile oil, mixing, check is distributed into every bag 6 gram or 3 grams, promptly.Fig. 1 is seen in technological process.
When granulating, granulator should note:
1. should heat up gradually from low to high earlier when granulating, avoid programming rate too fast, make material surface scleroma in bulk.
2. after spraying finishes, carry out drying, when dry can adjust exhaust damper control material particles in fluid bed inner height boiling generally at 20～40 minutes drying time, and in order to particle integrity, the granule that makes uses the stagewise shaking screen, sieves.
Characteristics of the present invention are: this product is brought down a fever fast and gentle (can not produce rebound phenomenon).Both can eliminate cold symptoms, again can the human body immunity improving ability.Untoward reaction is not seen in clinical practice.This product is a sugar type granules, has reduced the use amount of adjuvant, and the child administration amount reduces.Lactose is made adjuvant, and dissolubility is better.The one-step-granulating method spray granulation, the drug effect loss is little.
Quality control of the present invention is according to " 95 editions granule detections of Chinese pharmacopoeia down and the medicinal property of this product and work out and obtain approve to execute (adnexa 2) that the Ministry of Public Health pharmacopeia entrusts.
With following example in detail the present invention:
1. lot number 961012, and 10 times that shine above-mentioned recipe quantity feed intake, and method for making is identical with above-mentioned method for making, gets granule 10.2kg, send the check of institute for drug control, Sichuan Province, result: up to specification.
2. lot number 961013, and 10 times that shine above-mentioned recipe quantity feed intake, and method for making is identical with above-mentioned method for making, gets granule 10.0kg, send the check of institute for drug control, Sichuan Province, result: up to specification.
3. lot number 961014, and 10 times that shine above-mentioned recipe quantity feed intake, and method for making is identical with above-mentioned method for making, gets granule 10.1kg, send the check of institute for drug control, Sichuan Province, result: up to specification.
Claims (1)
- Get Radix Rehmanniae, Radix Cynanchi Atrati, Cortex Lycii, Gypsum Fibrosum (100g) according to prescription and decoct with water secondary, 3 hours for the first time, 1 hour for the second time, collecting decoction filtered; Flos Chrysanthemi, Folium Isatidis hot dipping secondary, 2 hours for the first time, 1 hour for the second time, merge leachate, filter; Herba Pogostemonis, Herba Menthae, Fructus Forsythiae extract volatile oil, and its aqueous solution filters, and filtrate and above two liquid merge, and being concentrated into relative density is the clear paste of 1.10～1.20 (50 ℃); Gypsum Fibrosum (25g), Radix Isatidis powder are broken into fine powder.1 part of 1 part of qinghuo reagent, lactose and fine powder, mixing is put and is made granule in the one-step-granulating method, sprays into volatile oil, mixing, check is distributed into every bag 6 gram or 3 grams, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97107520A CN1063646C (en) | 1997-05-29 | 1997-05-29 | Sugar-less particles for treating infant's cold and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97107520A CN1063646C (en) | 1997-05-29 | 1997-05-29 | Sugar-less particles for treating infant's cold and preparation method therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1200928A true CN1200928A (en) | 1998-12-09 |
| CN1063646C CN1063646C (en) | 2001-03-28 |
Family
ID=5169632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97107520A Expired - Lifetime CN1063646C (en) | 1997-05-29 | 1997-05-29 | Sugar-less particles for treating infant's cold and preparation method therefor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1063646C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2401042A (en) * | 2003-04-28 | 2004-11-03 | Pharmaceutical Ind Tech & Dev | Antitussive agent and method for making the same |
| CN100344320C (en) * | 2006-04-18 | 2007-10-24 | 邯郸制药有限公司 | Medicinal composition for treating children cold and its prepn. process |
| CN101274034B (en) * | 2007-03-27 | 2011-03-30 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for relieving exterior syndrome, clearing heat and detoxicating |
| CN102133301A (en) * | 2011-03-24 | 2011-07-27 | 江苏苏南药业实业有限公司 | Method for preparing pediatric cold granules |
| CN102614352A (en) * | 2011-02-01 | 2012-08-01 | 王平平 | Traditional Chinese medicine composition for treating infantile common cold, its preparation method and detection method |
| CN101744946B (en) * | 2010-01-15 | 2012-10-24 | 北京同仁堂科技发展股份有限公司 | Chinese medicinal composition and detection method for Chinese medicinal composition preparation |
| CN104383512A (en) * | 2014-12-08 | 2015-03-04 | 樊金刚 | Method for preparing pharmaceutical preparation for bringing down fever of children |
| CN104474514A (en) * | 2014-12-08 | 2015-04-01 | 樊金刚 | Chinese patent medicine for treating children fever |
| CN105663056A (en) * | 2016-03-01 | 2016-06-15 | 南京正亮医药科技有限公司 | Preparation method of granules for treating common cold in children and application of granules for treating common cold in children |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119978B (en) * | 2007-03-27 | 2012-10-31 | 北京亚东生物制药有限公司 | Composition for relieving exterior syndrome and clearing away heat and toxic materials, and preparation method and detection method thereof |
-
1997
- 1997-05-29 CN CN97107520A patent/CN1063646C/en not_active Expired - Lifetime
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2401042A (en) * | 2003-04-28 | 2004-11-03 | Pharmaceutical Ind Tech & Dev | Antitussive agent and method for making the same |
| GB2401042B (en) * | 2003-04-28 | 2006-02-22 | Pharmaceutical Ind Tech & Dev | Antitussive agent and method for making the same |
| US7569238B2 (en) * | 2003-04-28 | 2009-08-04 | Pharmaceutical Industry Technology And Development Center | Antitussive agent and method for making the same |
| CN100344320C (en) * | 2006-04-18 | 2007-10-24 | 邯郸制药有限公司 | Medicinal composition for treating children cold and its prepn. process |
| CN101274034B (en) * | 2007-03-27 | 2011-03-30 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for relieving exterior syndrome, clearing heat and detoxicating |
| CN101744946B (en) * | 2010-01-15 | 2012-10-24 | 北京同仁堂科技发展股份有限公司 | Chinese medicinal composition and detection method for Chinese medicinal composition preparation |
| CN102614352A (en) * | 2011-02-01 | 2012-08-01 | 王平平 | Traditional Chinese medicine composition for treating infantile common cold, its preparation method and detection method |
| CN102133301A (en) * | 2011-03-24 | 2011-07-27 | 江苏苏南药业实业有限公司 | Method for preparing pediatric cold granules |
| CN104383512A (en) * | 2014-12-08 | 2015-03-04 | 樊金刚 | Method for preparing pharmaceutical preparation for bringing down fever of children |
| CN104474514A (en) * | 2014-12-08 | 2015-04-01 | 樊金刚 | Chinese patent medicine for treating children fever |
| CN105663056A (en) * | 2016-03-01 | 2016-06-15 | 南京正亮医药科技有限公司 | Preparation method of granules for treating common cold in children and application of granules for treating common cold in children |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1063646C (en) | 2001-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1899535A (en) | Method for preparing dermopathic blood toxic capsule | |
| CN1063646C (en) | Sugar-less particles for treating infant's cold and preparation method therefor | |
| CN1135908A (en) | Medical food for curing acute and chronic pharyngitis | |
| CN1086429A (en) | The compound method of hard paralysed health | |
| CN101129588A (en) | Medicinal granules for conjunctivitis | |
| CN104491052B (en) | Traditional Chinese medicine composition for treating rheumatic and rheumatoid arthritis and preparation method thereof | |
| CN1437963A (en) | Medicine for treating common cold and preparation method | |
| CN1102105A (en) | Plaster for curing cough with dyspnea | |
| CN103638131B (en) | The medicine for the treatment of thrush | |
| CN102008557B (en) | Anti-influenza detoxifying capsules and preparation method thereof | |
| CN1278707C (en) | Fengtongning Chinese medicinal preparaton and its preparation method | |
| CN100367929C (en) | Preparation of Chinese traditional medicine for curing female inflammation and preparation method | |
| CN100352487C (en) | Pure Chinese medicine for treating chronic rhinitis, pharyngitis and globus hysterics | |
| CN1186056C (en) | Medicine for treating osteoproliferation | |
| CN1194733C (en) | Medicine for treating hyperthyroidism and its prepn | |
| CN1618439A (en) | Broad-specturm medicine for treating snake venom poisoning | |
| CN1103796A (en) | Dressing medicine for treating hyperosteogeny and the prepn. method | |
| CN1068039A (en) | Preparation of medicine powder for cholecystitis and cholelithiasis | |
| CN1232673A (en) | Chinese herbal decoction as oral liquid and its preparation and application | |
| CN101327255A (en) | Chinese medicine composing prescription applied externally for treating mastitis | |
| CN101874877A (en) | Medicine combination for promoting blood circulation and removing blood stasis and preparation method thereof | |
| CN1148201C (en) | Preparing method for auxiliary feedback treatment of disease medicine | |
| CN1064844C (en) | Chinese medicine | |
| CN1065132C (en) | Chinese medicinal preparation for treatment of prolapse of lumbar intervertebral disc | |
| CN1298728A (en) | 'Xiaozhi' pill for treating hemorrhoid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Yin Hai Document name: Notification to Pay the Fees |
|
| DD01 | Delivery of document by public notice |
Addressee: Yin Hai Document name: Notification to Pay the Fees |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20010328 |
|
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: Dikang Pharmaceutical Co., Chengdu Document name: Notification of Expiration of Patent Right Duration |