CN104474514A - Chinese patent medicine for treating children fever - Google Patents

Chinese patent medicine for treating children fever Download PDF

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Publication number
CN104474514A
CN104474514A CN201410739408.0A CN201410739408A CN104474514A CN 104474514 A CN104474514 A CN 104474514A CN 201410739408 A CN201410739408 A CN 201410739408A CN 104474514 A CN104474514 A CN 104474514A
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parts
radix
medicine
herba
fever
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樊金刚
高萍
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Individual
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention relates to the field of Chinese patent medicine preparations and discloses a Chinese patent medicine for treating children fever. The Chinese patent medicine preparation comprises the following main effective components: rehmannia, blackend swallowwort root, honeysuckle, pogostemon cablin, mint, licorice root, carapax eretmochelyos, dandelion, radix isatidis and the like. Aiming at the children fever, the Chinese patent medicine preparation can be used for treating both symptoms and root causes and is free of toxicity, harms and side effects to the human body, low in price, simple and convenient to prepare and wide in application prospect.

Description

A kind of Chinese Traditional Medicines for infantile fever
Technical field
The invention belongs to Chinese Traditional Medicines formulation art, be specifically related to a kind of Chinese Traditional Medicines for infantile fever.
Background technology
Motherland's medical science is thought, children's's body does not fill, and the flesh natural fibre line of meat is dredged thin, defends outer function not solid, not yet can well adapt to the change of weather, therefore easily for invading outside exopathogen, and cause fever.Modern medicine is thought, fever is the one reaction that human body resists disease, and the pathogenic microorganism causing child to have a fever mainly contains antibacterial, virus and mycoplasma, chlamydia.Definite pathogenesis still imperfectly understands, and is the result of many factors comprehensive function, and immunologic hypofunction is considered to one of major reason of falling ill.In prior art, (1) Physical temperature-lowering is roughly, as warm water or alcohol bath, ice bag cooling, normal saline enema etc. to the Therapeutic Method research of infantile fever; (2) drug cooling, as oral antipyretic, Metamizole nasal drip or the medicine such as intramuscular injection, intravenous drip dexamethasone, takes antibiont medicine to treat infection simultaneously; (3) herbal treatment: as oral traditional Chinese medicine preparation, the external application of Chinese medicine etc.All there is more defect in above-mentioned therapeutic modality, Physical temperature-lowering or simple Chinese medicine effect poor, by can not reduction body temperature efficiently and effectively, occur again after bringing down a fever that body temperature gos up soon, body temperature fluctuation be larger.Antibiotic therapy mainly adopts oral administration or intramuscular injection, the large approach of intravenous drip two.Infant oral antibiotic often can cause gastrointestinal reaction, the serious toxic and side effects such as also to cause allergic reaction, and infant is taken medicine more difficult simultaneously, is difficult to operation, and intramuscular injection or intravenous drip antibiotic, have a big risk, and operation easier is high, and infant is cry and screamed uneasiness, and pole is mismatched.
Children's's internal organs are tender and lovely, and skin hedge is not close, defend outer function solid, and cold warming up does not know self-regulated, weather cataclysm during Chang Yinsi in addition, and changes in temperature are not normal, and exopathogen is taken advantage of a weak point and sent out as primary disease; Again because children's is " pure-yang constituent " " YANG often being in excess, YIN often being in shortage ", diseases caused by exogenous pathogenic factor seasonal pathogen, is easy to heat-transformation, therefore clinical the most common with heat syndrome, and bringing down a fever rapidly is its primary treatment object." Plain Questions five is hidden and generated a section " thinks that lung spleen deficiency of kidney-QI is the key of its morbidity, and " all gas persons, all belong to lung." lung governing qi, department breathes, and has important regulating action to whole body mechanism of qi.The insufficiency of vital energy and blood of lung, then defend QI-insufficiency, thus spontaneous perspiration, easy diseases caused by exogenous pathogenic factor.Children's's the spleen tending to insufficiency usually, weakness of the spleen and stomach, fortune of receiving is not normal, and the biochemical weary source of QI and blood, inability of earth to generate metal, lung qi is also empty, is easy to diseases caused by exogenous pathogenic factor.Diseases caused by exogenous pathogenic factor repeatedly, prolonged illness is impairment of the kidney, and kidney is the root of Yuanyang, and it is not enough that deficiency of kidney-QI more causes lung spleen.Form vicious cycle.As can be seen here, treatment primary disease should lung benefiting strengthening spleen, tonifying kidney, benefiting QI for strengthening the superficies.Based on QI invigorating, kidney qi is sufficient, and the strong fortune of taste, then building up the spleen to supplement the lung, mutual generation between metal and water functional rehabilitation is normal.
Summary of the invention
The object of this invention is to provide that a kind for the treatment of both the principal and secondary aspects of a disease, side effect are little, safe ready, the cheap Chinese Traditional Medicines for infantile fever.Its objective is to solve treatment infantile fever, overcome dependency strong, side effect is large, reaches the object for the treatment of both the principal and secondary aspects of a disease.
The defect that present inventor exists in view of the medicine of existing treatment pediatrics febricide, based on being engaged in the clinical experience and Professional knowledge that Chinese medicine enriches for many years, from motherland's traditional medicine theory, in many ways the length of many families is collected, seek therapeutic regimen, for the body that children's is tender, not normal to changes in temperature, exopathogen is taken advantage of a weak point and is sent out, and diseases caused by exogenous pathogenic factor seasonal pathogen, is easy to heat-transformation, the disease of repeated infection, the present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, has stronger antiviral, antipyretic and anti-inflammatory, enhancing human body immunity effect;
For realizing above-mentioned purpose of the present invention, the technical solution used in the present invention is as follows:
For Chinese Traditional Medicines for infantile fever, it is characterized in that, described medicine is prepared by following raw material medicaments and obtains:
Radix Rehmanniae, Radix Cynanchi Atrati, Flos Lonicerae, Herba Pogostemonis, Herba Menthae, Radix Glycyrrhizae, Carapax Eretmochelydis, Herba Taraxaci, Radix Isatidis, Flos Chrysanthemi, Radix Platycodonis, Indigo Naturalis, Rhizoma Zingiberis Recens, the Rhizoma Anemarrhenae, Semen Persicae, Fructus Lycii, the Radix Astragali, Semen Coicis, Fructus Chaenomelis, Fructus Hordei Germinatus, Cortex Moutan.
Preferably, described medicine is prepared by the crude drug of following weight proportioning and obtains:
Radix Rehmanniae 28 parts, Radix Cynanchi Atrati 25 parts, Flos Lonicerae 25 parts, Herba Pogostemonis 25 parts,
Herba Menthae 20 parts, 20 parts, Radix Glycyrrhizae, Carapax Eretmochelydis 20 parts, Herba Taraxaci 20 parts,
Radix Isatidis 15 parts, Flos Chrysanthemi 15 parts, Radix Platycodonis 15 parts, Indigo Naturalis 15 parts,
15 parts, Rhizoma Zingiberis Recens, the Rhizoma Anemarrhenae 15 parts, 10 parts, Semen Persicae, Fructus Lycii 10 parts,
The Radix Astragali 10 parts, Semen Coicis 10 parts, Fructus Chaenomelis 8 parts, 8 parts, Fructus Hordei Germinatus, Cortex Moutan 5 parts.
The preparation method of described medicine is as follows:
(1) each crude drug is taken according to weight portion;
(2) get Radix Rehmanniae, Radix Cynanchi Atrati, Flos Lonicerae, Herba Taraxaci, Radix Isatidis, Flos Chrysanthemi, Indigo Naturalis, the Rhizoma Anemarrhenae, Semen Persicae, Fructus Lycii, Semen Coicis mix in described ratio; add 5 times of soak by water twice; 2 hours first times; second time 1 hour; merge twice decoction liquor; it is the extractum of 1.2g/ml that decoction liquor drying under reduced pressure is obtained density, after 80 DEG C of oven dry, obtains complex A;
(3) get residual components and add ethanol relative to mixture 5 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, and complex B is prepared in pulverizing;
(4) by complex A and complex B mixing and stirring and get final product.
Compound medicine of the present invention can add one or more pharmaceutically acceptable carriers and be mixed and made into any one clinically or pharmaceutically acceptable dosage form, preferred oral preparation.When being applied in the mode of oral administration the patient needing this treatment, conventional solid preparation can be made into, as tablet, capsule, soft capsule etc.
When preparation made by medicine of the present invention, the conventional method in existing pharmaceutical field can be adopted to produce, various pharmaceutically acceptable carrier when needs, can be added.Described carrier comprises the diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant etc. of pharmaceutical field routine.
Technical solutions according to the invention are on the clinical experience basis of Chinese traditional treatment infantile fever, obtain in conjunction with the development of modern pharmacy achievement.The present invention adopts the Chinese crude drug of different properties, can reach desirable therapeutic effect, and lasting medicine, is not easy repeatedly, the advantages such as toxic and side effects is little.
Tool of the present invention has the following advantages:
The present invention, by experiment repeatedly, determines the Different treatments of different Chinese crude drugs, retains effective ingredient to greatest extent, decrease wastage of material, saved cost;
Drug therapy infantile fever of the present invention is not easy repeatedly, and toxic and side effects is little.
Preparation technology's simple possible of medicine of the present invention, and cheap, can be applicable to large-scale industrialized production.
The present invention, by the choose reasonable to medicine components, proportioning, achieves desirable therapeutic effect, has both met state-promulgated pharmacopoeia to the requirement about drug dose, can ensure good therapeutic effect again, non-evident effect.
Detailed description of the invention
Embodiment 1
For Chinese Traditional Medicines for infantile fever, described medicine is prepared by the crude drug of following weight proportioning and obtains:
Radix Rehmanniae 28 parts, Radix Cynanchi Atrati 25 parts, Flos Lonicerae 25 parts, Herba Pogostemonis 25 parts,
Herba Menthae 20 parts, 20 parts, Radix Glycyrrhizae, Carapax Eretmochelydis 20 parts, Herba Taraxaci 20 parts,
Radix Isatidis 15 parts, Flos Chrysanthemi 15 parts, Radix Platycodonis 15 parts, Indigo Naturalis 15 parts,
15 parts, Rhizoma Zingiberis Recens, the Rhizoma Anemarrhenae 15 parts, 10 parts, Semen Persicae, Fructus Lycii 10 parts,
The Radix Astragali 10 parts, Semen Coicis 10 parts, Fructus Chaenomelis 8 parts, 8 parts, Fructus Hordei Germinatus, Cortex Moutan 5 parts.
The preparation method of described medicine is as follows:
(1) each crude drug is taken according to weight portion;
(2) get Radix Rehmanniae, Radix Cynanchi Atrati, Flos Lonicerae, Herba Taraxaci, Radix Isatidis, Flos Chrysanthemi, Indigo Naturalis, the Rhizoma Anemarrhenae, Semen Persicae, Fructus Lycii, Semen Coicis mix in described ratio; add 5 times of soak by water twice; 2 hours first times; second time 1 hour; merge twice decoction liquor; it is the extractum of 1.2g/ml that decoction liquor drying under reduced pressure is obtained density, after 80 DEG C of oven dry, obtains complex A;
(3) get residual components and add ethanol relative to mixture 5 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, and complex B is prepared in pulverizing;
(4) namely complex A and complex B mixing and stirring are obtained Effective Component of Chinese Medicine.
Embodiment 2
One, toxicity test:
This experiment adopts healthy SD rat, medicine prepared by oral administration embodiment 1, (Cmax: pharmacodynamics optium concentration 30 times), successive administration 30 days, during observing rat administration and after drug withdrawal, within 1 week, growth of animal state, movable diet, hematology, blood biochemical analysis, organs and tissues structure and routine urinalysis etc. all have no significant effect, and show that clinical drug safety is reliable.
Two, analgesic experiment:
BALB/c mouse acetic acid is caused to the effect of writhing response: BALB/c mouse 60, average weight is 25.7g, is divided into 3 groups at random, is respectively matched group, commercially available children's's benorylate dimension B1 group (the global pharmacy in Guangdong), embodiment 1 medicine group; Every day is administered once (matched group gives the normal saline of equivalent weight), continuous gastric infusion 3 days, and in last gastric infusion after 1 hour, lumbar injection 0.6% glacial acetic acid 0.2ml/ only, observes mouse writhing number of times in 20min, the results are shown in Table 1.
Table 1 mouse writhing number of times is added up
Group Mice number (only) Writhing number of times (30min)
Contrast 20 31.5
Commercially available children's's benorylate dimension B1 group 20 12.7
Embodiment 1 20 6.3
Conclusion: can be found by mouse writhing test, medicine prepared by embodiment 1 can play obvious analgesic activity.
To bring down a fever experiment
Fever model is set up: kunming mice 60, and 26-28g/ only, is divided into 3 groups at random, take temperature, respectively subcutaneous injection 2,4-dinitrophenol, 30mg/kg, make fever model, after 0.5 hour, detect body temperature, gavage gives drug dose is simultaneously that 0.25mg/kg(experimental group gives medicine, commercially available children's's benorylate dimension B1 group gives children's's benorylate dimension B1, and matched group gives the normal saline of equivalent weight), detect body temperature after 15 minutes.Concrete data see table 2.
Table 2 medicine is to the effect of bringing down a fever of mice
Group Mice number (only) Do not inject the body temperature before 2,4-dinitrophenol Injection 2,4-dinitrophenol 1 hour body temperature Gastric infusion 15 minutes body temperature
Matched group 20 36.8±0.14 39.0±0.25 39.0±0.33
Commercially available children's's benorylate dimension B1 group 20 37.0±0.07 38.9±0.27 37.6±0.41
Experimental group 20 37.0±0.08 38.9±0.31 37.2±0.24
Result display embodiment 1 is prepared medicine and to be brought down a fever Be very effective.
Embodiment 3
Model case
Tong, man, 5 years old, catch a cold after having a bath, cat fever continues the week more than one, and infant anorexia after having an injection of infusing, food is received and do not changed.Sometimes readme is suffered from abdominal pain, and is hard and dry.Time medical, body temperature 38.0 DEG C, still coughs intermittently.Disease see spirit still can, watery nasal discharge, colour of the tongue is micro-red, greasy in yellow fur, and fingerprint is purple.Give embodiment 1 and prepare medicine, one time 1/2nd bags, three times on the one, after one day, start head fever of the body and subtract, brothers turn temperature, and spirit is slightly shaken, lip profit mouth and; Continue to take 3 days, body temperature is normal, spiritual amelioration, and cough caused by the disorders of throat is only coughed, lip profit mouth and, know that hungry rope eat, two just lead to unblocked.Continue to take a course for the treatment of, return to one's perfect health, diet is normal.Drug withdrawal was followed up a case by regular visits to after two weeks, without recurrence.
Lee, female, 3 years old, flu, selected antibiotics, Western medicine of bringing down a fever, and move back during high heat, recurrent cough's first quarter moon is had a surplus, cough syrup, and Western medicine has been used and much loseed recovery from illness; Diagnosis: body temperature 38.2 DEG C, spiritual beach wormwood wastes, and whole body is lossless, and neck, body are scorching hot, throat hypodynia, and dysphagia, haves a medical check-up and see antiadoncus, speaks hoarse, tears sound.Give medicine prepared by embodiment 1, one time 1/3rd bags, one day three times, after one day, start head fever of the body and subtract, brothers turn temperature, and two is just logical unblocked, and spirit is slightly shaken, pharyngalgia only, lip profit mouth and, sound of speaking starts normally; Continue to take 3 days, body temperature is normal, and spiritual amelioration, throat enlargement is completely good, and tonsil no longer aches.Drug withdrawal is observed one week, and rehabilitation as before, is followed up a case by regular visits to without recurrence.
Although above done detailed explanation with general explanation and detailed description of the invention to this case, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, amendment done without departing from theon the basis of the spirit of the present invention or improvement, all belong to the scope of protection of present invention.

Claims (4)

1. for Chinese Traditional Medicines for infantile fever, it is characterized in that, described medicine is prepared by following raw material medicaments and obtains:
Radix Rehmanniae, Radix Cynanchi Atrati, Flos Lonicerae, Herba Pogostemonis, Herba Menthae, Radix Glycyrrhizae, Carapax Eretmochelydis, Herba Taraxaci, Radix Isatidis, Flos Chrysanthemi, Radix Platycodonis, Indigo Naturalis, Rhizoma Zingiberis Recens, the Rhizoma Anemarrhenae, Semen Persicae, Fructus Lycii, the Radix Astragali, Semen Coicis, Fructus Chaenomelis, Fructus Hordei Germinatus, Cortex Moutan.
2. medicine according to claim 1, is characterized in that: described medicine is prepared by the crude drug of following weight parts and obtains:
Radix Rehmanniae 28 parts, Radix Cynanchi Atrati 25 parts, Flos Lonicerae 25 parts, Herba Pogostemonis 25 parts,
Herba Menthae 20 parts, 20 parts, Radix Glycyrrhizae, Carapax Eretmochelydis 20 parts, Herba Taraxaci 20 parts,
Radix Isatidis 15 parts, Flos Chrysanthemi 15 parts, Radix Platycodonis 15 parts, Indigo Naturalis 15 parts,
15 parts, Rhizoma Zingiberis Recens, the Rhizoma Anemarrhenae 15 parts, 10 parts, Semen Persicae, Fructus Lycii 10 parts,
The Radix Astragali 10 parts, Semen Coicis 10 parts, Fructus Chaenomelis 8 parts, 8 parts, Fructus Hordei Germinatus, Cortex Moutan 5 parts.
3. the medicine according to claim 1-2, is characterized in that, the preparation method of described medicine is:
Each crude drug is taken according to weight portion;
Get Radix Rehmanniae, Radix Cynanchi Atrati, Flos Lonicerae, Herba Taraxaci, Radix Isatidis, Flos Chrysanthemi, Indigo Naturalis, the Rhizoma Anemarrhenae, Semen Persicae, Fructus Lycii and Semen Coicis; mixing; add the soak by water twice of 5 times of weight; 2 hours first times; second time 1 hour, merges twice decoction liquor, and it is the extractum of 1.2g/ml that decoction liquor drying under reduced pressure is obtained density; after 80 DEG C of oven dry, obtain complex A;
Get residual components, add the ethanol relative to mixture 5 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, pulverizes and prepares complex B;
By complex A and complex B mixing and stirring and get final product.
4. medicine described in claim 1-3 is used for the purposes of infantile fever.
CN201410739408.0A 2014-12-08 2014-12-08 Chinese patent medicine for treating children fever Pending CN104474514A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105125966A (en) * 2015-10-26 2015-12-09 王凯 Traditional Chinese medicine preparation treating appendiceal abscess

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200928A (en) * 1997-05-29 1998-12-09 成都迪康制药公司 Sugar-less particles for treating infant's cold and preparation method therefor
CN102793876A (en) * 2012-09-05 2012-11-28 成都中医药大学 Pharmaceutical composition for treating fever caused by unknown reason as well as preparation method and application of pharmaceutical composition
CN103432545A (en) * 2013-08-23 2013-12-11 王怀珍 Medicament for allaying fever of child and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200928A (en) * 1997-05-29 1998-12-09 成都迪康制药公司 Sugar-less particles for treating infant's cold and preparation method therefor
CN102793876A (en) * 2012-09-05 2012-11-28 成都中医药大学 Pharmaceutical composition for treating fever caused by unknown reason as well as preparation method and application of pharmaceutical composition
CN103432545A (en) * 2013-08-23 2013-12-11 王怀珍 Medicament for allaying fever of child and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
李春文 等: "小儿感冒颗粒治疗103例患儿的疗效观察", 《华西药学杂志》 *
田雅琴: "HPLC测定小儿感冒颗粒中绿原酸及连翘苷含量", 《中成药》 *
罗杰: "《新编家庭医生百科》", 31 March 2014 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105125966A (en) * 2015-10-26 2015-12-09 王凯 Traditional Chinese medicine preparation treating appendiceal abscess

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Application publication date: 20150401