CN1199045A - 取代的6－和7－氨基四氢异喹啉羧酸 - Google Patents
取代的6－和7－氨基四氢异喹啉羧酸 Download PDFInfo
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- CN1199045A CN1199045A CN98108315A CN98108315A CN1199045A CN 1199045 A CN1199045 A CN 1199045A CN 98108315 A CN98108315 A CN 98108315A CN 98108315 A CN98108315 A CN 98108315A CN 1199045 A CN1199045 A CN 1199045A
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- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| DE19719817.1 | 1997-05-13 | ||
| DE19719817A DE19719817A1 (de) | 1997-05-13 | 1997-05-13 | Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren |
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| Publication Number | Publication Date |
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| CN1199045A true CN1199045A (zh) | 1998-11-18 |
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| CN98108315A Pending CN1199045A (zh) | 1997-05-13 | 1998-05-12 | 取代的6－和7－氨基四氢异喹啉羧酸 |
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| DE (2) | DE19719817A1 (https=) |
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| PT (1) | PT878467E (https=) |
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| TR (1) | TR199800841A3 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW464652B (en) | 1996-10-30 | 2001-11-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| FR2795730B1 (fr) * | 1999-07-01 | 2001-08-31 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1263453A4 (en) * | 1999-12-31 | 2008-02-20 | Univ Rutgers | PHARMACEUTICAL FORMULATION CONSISTING OF A POLYMERMATRIX, FOR REGULATING THE TIME-CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES |
| US7521061B2 (en) * | 1999-12-31 | 2009-04-21 | Rutgers, The State University Of New Jersey | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| EP1208092B1 (en) * | 2000-04-07 | 2006-06-21 | Samsung Electronics Co., Ltd. | Sulfonamide derivative as a matrix metalloproteinase inhibitor |
| GB0011409D0 (en) * | 2000-05-11 | 2000-06-28 | Smithkline Beecham Plc | Novel compounds |
| WO2003016248A2 (en) * | 2001-08-17 | 2003-02-27 | Bristol-Myers Squibb Company Patent Department | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace) |
| US6566524B2 (en) * | 2001-12-21 | 2003-05-20 | The Procter & Gamble Co. | Methods for synthesis of amino-tetrahydroisoquinoline-sulfonamide hydroxamic acids |
| US6608193B2 (en) | 2001-12-21 | 2003-08-19 | The Procter & Gamble Company | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds |
| US20020055637A1 (en) * | 2001-12-21 | 2002-05-09 | Song Liu | Methods for synthesis of amino-tetrahydroisoquinoline-carboxylic acids |
| JP2006500350A (ja) * | 2002-08-13 | 2006-01-05 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | マトリックスメタロプロテイナーゼ阻害剤としてのイソキノリン誘導体 |
| DE10344936A1 (de) * | 2003-09-27 | 2005-04-21 | Aventis Pharma Gmbh | Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen |
| US7576222B2 (en) | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
| DE102005015040A1 (de) * | 2005-03-31 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| JP5098011B2 (ja) * | 2006-11-20 | 2012-12-12 | 国立大学法人山口大学 | 創傷治癒促進剤 |
| GB0706072D0 (en) * | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU575349A1 (ru) * | 1975-12-29 | 1977-10-05 | Донецкий государственный университет | Способ получени арилсульфонамидных производных 1,2-дигидрохинолина |
| US4315935A (en) * | 1980-04-14 | 1982-02-16 | Smithkline Corporation | N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use |
| US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| US4681889A (en) * | 1985-12-02 | 1987-07-21 | Syntex (U.S.A.) Inc. | Method for treating cardiovascular disease with calcium channel antagonists |
| US4613606A (en) * | 1985-12-02 | 1986-09-23 | Syntex (U.S.A.) Inc. | Tetrahydroisoquinoline derivatives |
| JP2764262B2 (ja) * | 1987-08-28 | 1998-06-11 | 持田製薬株式会社 | ヒダントイン誘導体及びそれを有効成分とする医薬組成物 |
| TW201303B (https=) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| US5552419A (en) * | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| FR2701480B1 (fr) * | 1993-02-15 | 1995-05-24 | Sanofi Elf | Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
| US5714497A (en) * | 1993-02-15 | 1998-02-03 | Sanofi | Compounds bearing sulphamoyl and amidino radicals, their preparation process and pharmaceutical compositions containing them |
| AU2394795A (en) * | 1994-04-28 | 1995-11-29 | Du Pont Merck Pharmaceutical Company, The | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
| JPH10501806A (ja) * | 1994-06-22 | 1998-02-17 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | 金属タンパク質分解酵素阻害剤 |
| US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| DK0821671T3 (da) * | 1995-04-20 | 2001-04-23 | Pfizer | Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer |
| RU2164914C2 (ru) * | 1995-11-13 | 2001-04-10 | Хехст Акциенгезелльшафт | ЦИКЛИЧЕСКИЕ И ГЕТЕРОЦИКЛИЧЕСКИЕ N-ЗАМЕЩЕННЫЕ α-ИМИНОГИДРОКСАМОВЫЕ И КАРБОНОВЫЕ КИСЛОТЫ |
| GB9613547D0 (en) * | 1996-06-27 | 1996-08-28 | Pharmacia Spa | Matrix metalloproteinase inhibitors |
-
1997
- 1997-05-13 DE DE19719817A patent/DE19719817A1/de not_active Withdrawn
-
1998
- 1998-05-02 DE DE59801919T patent/DE59801919D1/de not_active Expired - Lifetime
- 1998-05-02 PT PT98108039T patent/PT878467E/pt unknown
- 1998-05-02 EP EP98108039A patent/EP0878467B1/de not_active Expired - Lifetime
- 1998-05-02 AT AT98108039T patent/ATE207903T1/de not_active IP Right Cessation
- 1998-05-02 ES ES98108039T patent/ES2166577T3/es not_active Expired - Lifetime
- 1998-05-02 DK DK98108039T patent/DK0878467T3/da active
- 1998-05-11 CZ CZ981452A patent/CZ145298A3/cs unknown
- 1998-05-11 AR ARP980102174A patent/AR012684A1/es unknown
- 1998-05-11 TR TR1998/00841A patent/TR199800841A3/tr unknown
- 1998-05-11 US US09/075,186 patent/US5962471A/en not_active Expired - Lifetime
- 1998-05-12 CN CN98108315A patent/CN1199045A/zh active Pending
- 1998-05-12 RU RU98109049/04A patent/RU2212405C2/ru not_active IP Right Cessation
- 1998-05-12 CA CA002237382A patent/CA2237382A1/en not_active Abandoned
- 1998-05-12 BR BR9803694A patent/BR9803694A/pt not_active IP Right Cessation
- 1998-05-12 HU HU9801072A patent/HUP9801072A3/hu unknown
- 1998-05-13 KR KR1019980017082A patent/KR19980086989A/ko not_active Ceased
- 1998-05-13 JP JP13075298A patent/JP4384277B2/ja not_active Expired - Fee Related
- 1998-05-13 AU AU65938/98A patent/AU731079B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE19719817A1 (de) | 1998-11-19 |
| PT878467E (pt) | 2002-04-29 |
| ATE207903T1 (de) | 2001-11-15 |
| AR012684A1 (es) | 2000-11-08 |
| AU731079B2 (en) | 2001-03-22 |
| BR9803694A (pt) | 2000-03-21 |
| KR19980086989A (ko) | 1998-12-05 |
| RU2212405C2 (ru) | 2003-09-20 |
| US5962471A (en) | 1999-10-05 |
| HUP9801072A2 (hu) | 1999-02-01 |
| TR199800841A2 (xx) | 1998-12-21 |
| HU9801072D0 (en) | 1998-07-28 |
| TR199800841A3 (tr) | 1998-12-21 |
| AU6593898A (en) | 1998-11-19 |
| ES2166577T3 (es) | 2002-04-16 |
| CZ145298A3 (cs) | 1998-12-16 |
| JP4384277B2 (ja) | 2009-12-16 |
| JPH10316662A (ja) | 1998-12-02 |
| DK0878467T3 (da) | 2002-02-18 |
| HUP9801072A3 (en) | 1999-03-29 |
| DE59801919D1 (de) | 2001-12-06 |
| EP0878467A1 (de) | 1998-11-18 |
| CA2237382A1 (en) | 1998-11-13 |
| EP0878467B1 (de) | 2001-10-31 |
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