CN119707784A - 氨基酸衍生物的制备方法 - Google Patents
氨基酸衍生物的制备方法 Download PDFInfo
- Publication number
- CN119707784A CN119707784A CN202411902931.0A CN202411902931A CN119707784A CN 119707784 A CN119707784 A CN 119707784A CN 202411902931 A CN202411902931 A CN 202411902931A CN 119707784 A CN119707784 A CN 119707784A
- Authority
- CN
- China
- Prior art keywords
- general formula
- compound represented
- group
- acid
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018-177774 | 2018-09-21 | ||
| JP2018177774 | 2018-09-21 | ||
| CN201980061666.9A CN112930338B (zh) | 2018-09-21 | 2019-09-24 | 氨基酸衍生物的制备方法 |
| PCT/JP2019/037399 WO2020059891A1 (ja) | 2018-09-21 | 2019-09-24 | アミノ酸誘導体の製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980061666.9A Division CN112930338B (zh) | 2018-09-21 | 2019-09-24 | 氨基酸衍生物的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119707784A true CN119707784A (zh) | 2025-03-28 |
Family
ID=69887293
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411902931.0A Pending CN119707784A (zh) | 2018-09-21 | 2019-09-24 | 氨基酸衍生物的制备方法 |
| CN201980061666.9A Active CN112930338B (zh) | 2018-09-21 | 2019-09-24 | 氨基酸衍生物的制备方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980061666.9A Active CN112930338B (zh) | 2018-09-21 | 2019-09-24 | 氨基酸衍生物的制备方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11897844B2 (https=) |
| EP (1) | EP3854786B1 (https=) |
| JP (2) | JP7523354B2 (https=) |
| CN (2) | CN119707784A (https=) |
| WO (1) | WO2020059891A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119707784A (zh) * | 2018-09-21 | 2025-03-28 | 株式会社Api | 氨基酸衍生物的制备方法 |
| KR102698832B1 (ko) * | 2022-09-14 | 2024-08-26 | 김형식 | 엑토인의 제조방법 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2533826T3 (es) | 2008-01-18 | 2015-04-15 | Merck Sharp & Dohme Corp. | Inhibidores de beta-lactamasa |
| US20120053350A1 (en) | 2009-04-30 | 2012-03-01 | Ian Mangion | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| JP2013516422A (ja) * | 2009-12-30 | 2013-05-13 | アビラ セラピューティクス， インコーポレイテッド | タンパク質のリガンド−指向性共有的修飾 |
| SI2657234T1 (sl) * | 2010-12-22 | 2017-06-30 | Meiji Seika Pharma Co., Ltd. | Derivat optično-aktivnega diazabiciklooktana in metoda za njegovo izdelavo |
| US8772490B2 (en) * | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| KR102143660B1 (ko) * | 2011-06-17 | 2020-08-11 | 화이자 안티-인펙티브스 에이비 | 트랜스-7-옥소-6-(술포옥시)-1,6-디아자비시클로[3,2,1]옥탄-2-카르복스아미드 및 그의 염을 포함하는 헤테로시클릭 화합물의 제조 방법 |
| TW201343645A (zh) * | 2012-03-30 | 2013-11-01 | Cubist Pharm Inc | １，３，４－□二唑及１，３，４－噻二唑β－內醯胺酶抑制劑 |
| US8969570B2 (en) * | 2012-03-30 | 2015-03-03 | Cubist Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| RU2693898C2 (ru) | 2012-05-30 | 2019-07-05 | Мейдзи Сейка Фарма Ко., Лтд. | НОВЫЙ ИНГИБИТОР бета-ЛАКТАМАЗЫ И СПОСОБ ЕГО ПОЛУЧЕНИЯ |
| ES2693568T3 (es) * | 2012-12-20 | 2018-12-12 | Api Corporation | Método para producir un derivado de ácido cis-5-hidroxi-2-piperidincarboxílico, y método para purificar ácido cis-5-hidroxi-2-piperidincarboxílico |
| CN104685061B (zh) | 2013-02-19 | 2018-05-01 | 株式会社Api | L-赖氨酸羟化酶和利用了该l-赖氨酸羟化酶的羟基-l-赖氨酸的制造法及羟基-l-2-哌啶酸的制造法 |
| US9120795B2 (en) * | 2013-03-14 | 2015-09-01 | Cubist Pharmaceuticals, Inc. | Crystalline form of a β-lactamase inhibitor |
| AU2014278556B2 (en) * | 2013-06-10 | 2018-07-19 | Merck Sharp & Dohme Llc | Preparation of tert-butyl 4-((1R,2S,5R)-6- (benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2- carboxamido)piperidine-1-carboxylate |
| DK3050883T3 (da) * | 2013-09-24 | 2020-05-25 | Meiji Seika Pharma Co Ltd | Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter |
| EP3613740A1 (en) * | 2013-10-08 | 2020-02-26 | Meiji Seika Pharma Co., Ltd. | Preparation of a diazabicyclooctane derivative |
| JP6539212B2 (ja) | 2013-12-26 | 2019-07-03 | 株式会社カネカ | 光学活性環状イミノ酸の製造方法 |
| JP6687238B2 (ja) | 2013-12-27 | 2020-04-22 | 株式会社エーピーアイ コーポレーション | ５−ヒドロキシピペリジン−２−カルボン酸の製造方法 |
| WO2015173779A1 (en) | 2014-05-16 | 2015-11-19 | Micro Labs Limited | Process for the preparation of teneligliptin and its novel intermediates |
| US10087139B2 (en) * | 2015-03-03 | 2018-10-02 | Toray Fine Chemicals Co., Ltd. | 3-Phenylisoserine derivative production method |
| CN105061425B (zh) * | 2015-08-13 | 2017-01-11 | 广州楷模生物科技有限公司 | 二氮杂双环辛酮硫酸单酯的合成方法 |
| EP3281942A4 (en) * | 2015-09-16 | 2018-08-15 | Xuanzhu Pharma Co., Ltd. | B-lactamase inhibitor and application thereof |
| CN106749242B (zh) * | 2015-11-23 | 2021-04-02 | 上海医药工业研究院 | 阿维巴坦中间体的制备方法 |
| US10501464B2 (en) * | 2015-12-11 | 2019-12-10 | Wockhardt Limited | 7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide containing compounds and their use in treating bacterial infections |
| WO2017167218A1 (zh) * | 2016-03-31 | 2017-10-05 | 山东轩竹医药科技有限公司 | 一种抗菌组合物及其用途 |
| JOP20190061A1 (ar) * | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
| US20200325139A1 (en) * | 2017-12-22 | 2020-10-15 | Assistance Publique-Hopitaux De Paris | New antibiotics targeting mycobacteria |
| CN109970625B (zh) * | 2017-12-28 | 2021-02-26 | 新发药业有限公司 | 一种5r-苄氧氨基哌啶-2s-甲酸或其衍生物的制备方法 |
| CN119707784A (zh) * | 2018-09-21 | 2025-03-28 | 株式会社Api | 氨基酸衍生物的制备方法 |
| CN114206851B (zh) * | 2019-04-26 | 2025-02-11 | 默沙东有限责任公司 | 可用于制备(2s,5r)-7-氧代-n-哌啶-4-基-6-(硫酸基)-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺的中间体的制备方法 |
-
2019
- 2019-09-24 CN CN202411902931.0A patent/CN119707784A/zh active Pending
- 2019-09-24 US US17/277,456 patent/US11897844B2/en active Active
- 2019-09-24 CN CN201980061666.9A patent/CN112930338B/zh active Active
- 2019-09-24 EP EP19863035.2A patent/EP3854786B1/en active Active
- 2019-09-24 WO PCT/JP2019/037399 patent/WO2020059891A1/ja not_active Ceased
- 2019-09-24 JP JP2020549244A patent/JP7523354B2/ja active Active
-
2023
- 2023-09-07 US US18/243,409 patent/US12202800B2/en active Active
- 2023-12-20 US US18/390,624 patent/US12281074B2/en active Active
-
2024
- 2024-05-09 JP JP2024076378A patent/JP7790473B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US12281074B2 (en) | 2025-04-22 |
| EP3854786A1 (en) | 2021-07-28 |
| CA3113606A1 (en) | 2020-03-26 |
| US12202800B2 (en) | 2025-01-21 |
| CN112930338A (zh) | 2021-06-08 |
| WO2020059891A1 (ja) | 2020-03-26 |
| JP7790473B2 (ja) | 2025-12-23 |
| EP3854786C0 (en) | 2026-02-18 |
| EP3854786B1 (en) | 2026-02-18 |
| US11897844B2 (en) | 2024-02-13 |
| JPWO2020059891A1 (ja) | 2021-08-30 |
| CN112930338B (zh) | 2024-12-24 |
| US20210403427A1 (en) | 2021-12-30 |
| EP3854786A4 (en) | 2022-09-14 |
| JP7523354B2 (ja) | 2024-07-26 |
| JP2024105463A (ja) | 2024-08-06 |
| US20240002340A1 (en) | 2024-01-04 |
| US20240150292A1 (en) | 2024-05-09 |
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Legal Events
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |