CN1196784C - 人内皮特异受体基因的启动子及其用途 - Google Patents

人内皮特异受体基因的启动子及其用途 Download PDF

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Publication number
CN1196784C
CN1196784C CNB981063500A CN98106350A CN1196784C CN 1196784 C CN1196784 C CN 1196784C CN B981063500 A CNB981063500 A CN B981063500A CN 98106350 A CN98106350 A CN 98106350A CN 1196784 C CN1196784 C CN 1196784C
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nucleic acid
sequence
acid construct
endothelium
disease
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Expired - Fee Related
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Chinese (zh)
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CN1203948A (zh
Inventor
W·格劳里克
D·奈特尔贝克
H-H·赛德拉西克
R·默勒
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Hoechst AG
Sanofi Aventis Deutschland GmbH
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Aventis Pharma Deutschland GmbH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
CNB981063500A 1997-02-06 1998-02-05 人内皮特异受体基因的启动子及其用途 Expired - Fee Related CN1196784C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19704301.1 1997-02-06
DE19704301A DE19704301C1 (de) 1997-02-06 1997-02-06 Der Promotor des humanen Endoglingens und seine Verwendung für die Gentherapie

Publications (2)

Publication Number Publication Date
CN1203948A CN1203948A (zh) 1999-01-06
CN1196784C true CN1196784C (zh) 2005-04-13

Family

ID=7819364

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB981063500A Expired - Fee Related CN1196784C (zh) 1997-02-06 1998-02-05 人内皮特异受体基因的启动子及其用途

Country Status (15)

Country Link
US (1) US6103527A (enExample)
EP (1) EP0857781A3 (enExample)
JP (1) JPH11178A (enExample)
KR (1) KR19980071084A (enExample)
CN (1) CN1196784C (enExample)
AR (1) AR011110A1 (enExample)
AU (1) AU736724B2 (enExample)
BR (1) BR9800563A (enExample)
CA (1) CA2222981A1 (enExample)
CZ (1) CZ289227B6 (enExample)
DE (1) DE19704301C1 (enExample)
HU (1) HUP9800247A3 (enExample)
PL (1) PL324688A1 (enExample)
RU (1) RU2230115C2 (enExample)
TR (1) TR199800168A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19704301C1 (de) * 1997-02-06 1998-03-26 Hoechst Ag Der Promotor des humanen Endoglingens und seine Verwendung für die Gentherapie
HUP9900956A2 (hu) 1998-04-09 2002-04-29 Aventis Pharma Deutschland Gmbh. Egyláncú, több antigéntkötőhely kialakítására képes molekulák, előállításuk és alkalmazásuk
DE60013586T2 (de) 1999-04-02 2005-02-03 Hisamitsu Pharmaceutical Co., Inc., Tosu Genexpressions-basensequenzen zur therapeutischen anwendung und heilmittel zur gentherapie
RU2295281C2 (ru) * 2005-04-20 2007-03-20 Федеральное государственное учреждение Научно-исследовательский институт детских инфекций, г.Санкт-Петербург Способ оценки тяжести инфекционного поражения цнс у детей
RU2297848C2 (ru) * 2005-05-11 2007-04-27 Александр Веньяминович Иткес Генно-инженерная конструкция vegf-ибмед (vegf-ibmed)
US20090136465A1 (en) 2007-09-28 2009-05-28 Intrexon Corporation Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
EP2310507A4 (en) 2008-07-08 2013-03-20 David Gladstone Inst METHOD AND COMPOSITIONS FOR ANGIOGENIC MODULATION
EP2951306A4 (en) 2013-01-30 2016-07-27 Univ Nebraska COMPOSITIONS AND METHOD FOR TREATING COMPLICATIONS RELATED TO DIABETES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466596A (en) * 1992-08-25 1995-11-14 Mount Sinai Hospital Corporation Tissue specific transcriptional regulatory element
GB9506466D0 (en) * 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
DE19704301C1 (de) * 1997-02-06 1998-03-26 Hoechst Ag Der Promotor des humanen Endoglingens und seine Verwendung für die Gentherapie

Also Published As

Publication number Publication date
EP0857781A2 (de) 1998-08-12
JPH11178A (ja) 1999-01-06
TR199800168A2 (xx) 1998-08-21
KR19980071084A (ko) 1998-10-26
RU2230115C2 (ru) 2004-06-10
CA2222981A1 (en) 1998-08-06
HUP9800247A3 (en) 2002-11-28
AU736724B2 (en) 2001-08-02
CZ33298A3 (cs) 1998-08-12
US6103527A (en) 2000-08-15
HU9800247D0 (en) 1998-03-30
AU5293198A (en) 1998-08-13
HUP9800247A2 (hu) 1998-10-28
BR9800563A (pt) 1999-06-29
AR011110A1 (es) 2000-08-02
CZ289227B6 (cs) 2001-12-12
CN1203948A (zh) 1999-01-06
PL324688A1 (en) 1998-08-17
EP0857781A3 (de) 2001-05-16
DE19704301C1 (de) 1998-03-26
MX9800981A (es) 1998-08-30

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